>PSL4_HUMAN (Q8TCT6) Signal peptide peptidase-like 3 (EC 3.4.23.-) (SPP-like 3|
           protein) (Intramembrane protease 2) (IMP2)
           (Presenilin-like protein 4)
          Length = 385

 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 35/106 (33%), Positives = 56/106 (52%), Gaps = 6/106 (5%)
 Frame = -3

Query: 532 LALVLSFDHRKSK------DVTVTSDLSPSSKRRKYVWFALTGYGVGLVTALAAGILSQS 371
           L  VL +D+ K +           +++S   ++  Y    L GY VGL+TA  A  + ++
Sbjct: 280 LCFVLRYDNYKKQASGDSCGAPGPANISGRMQKVSYFHCTLIGYFVGLLTATVASRIHRA 339

Query: 370 PQPALLYLVPSTLGPVVYLSWLRNDLWELWEGSTTIVNEKAHLLEV 233
            QPALLYLVP TL P++ +++L+ DL  +W       +  +  LEV
Sbjct: 340 AQPALLYLVPFTLLPLLTMAYLKGDLRRMWSEPFHSKSSSSRFLEV 385

>PSL4_MOUSE (Q9CUS9) Signal peptide peptidase-like 3 (EC 3.4.23.-) (SPP-like 3|
           protein) (Intramembrane protease 2) (IMP2)
           (Presenilin-like protein 4)
          Length = 384

 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 35/106 (33%), Positives = 56/106 (52%), Gaps = 6/106 (5%)
 Frame = -3

Query: 532 LALVLSFDHRKSK------DVTVTSDLSPSSKRRKYVWFALTGYGVGLVTALAAGILSQS 371
           L  VL +D+ K +           +++S   ++  Y    L GY VGL+TA  A  + ++
Sbjct: 279 LCFVLRYDNYKKQASGDSCGAPGPANISGRMQKVSYFHCTLIGYFVGLLTATVASRIHRA 338

Query: 370 PQPALLYLVPSTLGPVVYLSWLRNDLWELWEGSTTIVNEKAHLLEV 233
            QPALLYLVP TL P++ +++L+ DL  +W       +  +  LEV
Sbjct: 339 AQPALLYLVPFTLLPLLTMAYLKGDLRRMWSEPFHSKSSSSRFLEV 384

>PSL2_MOUSE (Q9JJF9) Signal peptide peptidase-like 2A (EC 3.4.23.-) (SPP-like|
           2A protein) (SPPL2a protein) (Intramembrane protease 3)
           (IMP3) (Presenilin-like protein 2)
          Length = 523

 Score = 46.6 bits (109), Expect = 4e-05
 Identities = 20/51 (39%), Positives = 33/51 (64%)
 Frame = -3

Query: 421 YGVGLVTALAAGILSQSPQPALLYLVPSTLGPVVYLSWLRNDLWELWEGST 269
           Y VG++      ++ ++ QPALLYLVP TL  V  ++W R ++ + W+GS+
Sbjct: 447 YAVGMIITFVVLMVMKTGQPALLYLVPCTLITVSVVAWSRKEMKKFWKGSS 497

>PSL2_HUMAN (Q8TCT8) Signal peptide peptidase-like 2A (EC 3.4.23.-) (Protein|
           SPP-like 2A) (Protein SPPL2a) (Intramembrane protease 3)
           (IMP3) (Presenilin-like protein 2)
          Length = 520

 Score = 45.8 bits (107), Expect = 7e-05
 Identities = 19/61 (31%), Positives = 36/61 (59%), Gaps = 2/61 (3%)
 Frame = -3

Query: 445 YVWF--ALTGYGVGLVTALAAGILSQSPQPALLYLVPSTLGPVVYLSWLRNDLWELWEGS 272
           Y+++  +   Y +G++      +L +  QPALLYLVP TL     ++W R ++ + W+G+
Sbjct: 434 YIYYVSSTVAYAIGMILTFVVLVLMKKGQPALLYLVPCTLITASVVAWRRKEMKKFWKGN 493

Query: 271 T 269
           +
Sbjct: 494 S 494

>PSL1_HUMAN (Q8TCT7) Signal peptide peptidase-like 2B (EC 3.4.23.-) (Protein|
           SPP-like 2B) (Protein SPPL2b) (Intramembrane protease 4)
           (IMP4) (Presenilin-like protein 1)
          Length = 592

 Score = 45.1 bits (105), Expect = 1e-04
 Identities = 32/85 (37%), Positives = 41/85 (48%)
 Frame = -3

Query: 526 LVLSFDHRKSKDVTVTSDLSPSSKRRKYVWFALTGYGVGLVTALAAGILSQSPQPALLYL 347
           L++++ HR   D+ V S        R Y       YGVGL+    A  L Q  QPALLYL
Sbjct: 427 LLVAYCHRF--DIQVQSS-------RVYFVACTIAYGVGLLVTFVALALMQRGQPALLYL 477

Query: 346 VPSTLGPVVYLSWLRNDLWELWEGS 272
           VP TL     ++  R +L   W GS
Sbjct: 478 VPCTLVTSCAVALWRRELGVFWTGS 502

>PSL1_MOUSE (Q3TD49) Signal peptide peptidase-like 2B (EC 3.4.23.-) (Protein|
           SPP-like 2B) (Protein SPPL2b)
          Length = 578

 Score = 45.1 bits (105), Expect = 1e-04
 Identities = 27/68 (39%), Positives = 36/68 (52%)
 Frame = -3

Query: 475 DLSPSSKRRKYVWFALTGYGVGLVTALAAGILSQSPQPALLYLVPSTLGPVVYLSWLRND 296
           D+   S R  +V   +  YG+GL+    A +L Q  QPALLYLVP TL     ++  R +
Sbjct: 429 DIQVQSSRIYFVACTIA-YGLGLLVTFVALVLMQRGQPALLYLVPCTLLTSCTVALWRRE 487

Query: 295 LWELWEGS 272
           L   W GS
Sbjct: 488 LGAFWTGS 495

>PSL1_CHICK (Q5F383) Signal peptide peptidase-like 2B (EC 3.4.23.-) (Protein|
           SPP-like 2B) (Protein SPPL2b)
          Length = 596

 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 31/85 (36%), Positives = 41/85 (48%)
 Frame = -3

Query: 526 LVLSFDHRKSKDVTVTSDLSPSSKRRKYVWFALTGYGVGLVTALAAGILSQSPQPALLYL 347
           L++++ HR   D+ V S        R Y       YG+GL+    A  L Q  QPALLYL
Sbjct: 423 LLVAYCHRF--DIQVQSS-------RVYFVACTIAYGIGLLVTFVALALMQMGQPALLYL 473

Query: 346 VPSTLGPVVYLSWLRNDLWELWEGS 272
           VP TL     ++  R +L   W GS
Sbjct: 474 VPCTLITSFSVALWRKELAMFWTGS 498

>YJ95_CAEEL (P49049) Hypothetical protein T05E11.5 in chromosome IV|
          Length = 468

 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 28/84 (33%), Positives = 41/84 (48%)
 Frame = -3

Query: 532 LALVLSFDHRKSKDVTVTSDLSPSSKRRKYVWFALTGYGVGLVTALAAGILSQSPQPALL 353
           +AL+  FD+R  +    +     S K R Y    +  Y  GL   +A     ++ QPALL
Sbjct: 361 IALLRRFDYRVVQTTAESKAPQGSLKGRYYFVVTVVAYMAGLFITMAVMHHFKAAQPALL 420

Query: 352 YLVPSTLGPVVYLSWLRNDLWELW 281
           YLVP  L   + L+ +R +L  LW
Sbjct: 421 YLVPCCLFVPLLLAVIRGELSALW 444

>PSL1_RAT (Q5PQL3) Signal peptide peptidase-like 2B (EC 3.4.23.-) (Protein|
           SPP-like 2B) (Protein SPPL2b)
          Length = 577

 Score = 42.7 bits (99), Expect = 6e-04
 Identities = 25/68 (36%), Positives = 36/68 (52%)
 Frame = -3

Query: 475 DLSPSSKRRKYVWFALTGYGVGLVTALAAGILSQSPQPALLYLVPSTLGPVVYLSWLRND 296
           D+   S R  +V   +  YG+GL+    A +L +  QPALLYLVP TL     ++  R +
Sbjct: 429 DIQVQSSRIYFVACTIA-YGLGLLVTFVALVLMRHGQPALLYLVPCTLLTSCTVALWRRE 487

Query: 295 LWELWEGS 272
           +   W GS
Sbjct: 488 MGAFWTGS 495

>YKK0_YEAST (P34248) Hypothetical 67.5 kDa protein in APE1/LAP4-CWP1 intergenic|
           region
          Length = 587

 Score = 38.5 bits (88), Expect = 0.012
 Identities = 19/56 (33%), Positives = 30/56 (53%)
 Frame = -3

Query: 448 KYVWFALTGYGVGLVTALAAGILSQSPQPALLYLVPSTLGPVVYLSWLRNDLWELW 281
           KY   A+  Y   LV+A+ +  +  + QPALLY+VPS L   + ++    D  + W
Sbjct: 449 KYFITAMVSYVASLVSAMVSLSIFNTAQPALLYIVPSLLISTILVACWNKDFKQFW 504

>HM13_HUMAN (Q8TCT9) Minor histocompatibility antigen H13 (EC 3.4.99.-) (Signal|
           peptide peptidase) (Presenilin-like protein 3) (hIMP1
           protein)
          Length = 377

 Score = 33.5 bits (75), Expect = 0.38
 Identities = 18/65 (27%), Positives = 33/65 (50%)
 Frame = -3

Query: 475 DLSPSSKRRKYVWFALTGYGVGLVTALAAGILSQSPQPALLYLVPSTLGPVVYLSWLRND 296
           D+S       Y + +   Y  GL   +    + +  QPALLYLVP+ +G  V ++  + +
Sbjct: 280 DISLKKNTHTYFYTSFAAYIFGLGLTIFIMHIFKHAQPALLYLVPACIGFPVLVALAKGE 339

Query: 295 LWELW 281
           + E++
Sbjct: 340 VTEMF 344

>HM13_MOUSE (Q9D8V0) Minor histocompatibility antigen H13 (EC 3.4.99.-) (Signal|
           peptide peptidase) (Presenilin-like protein 3)
          Length = 378

 Score = 33.1 bits (74), Expect = 0.50
 Identities = 18/65 (27%), Positives = 33/65 (50%)
 Frame = -3

Query: 475 DLSPSSKRRKYVWFALTGYGVGLVTALAAGILSQSPQPALLYLVPSTLGPVVYLSWLRND 296
           D+S       Y + +   Y  GL   +    + +  QPALLYLVP+ +G  V ++  + +
Sbjct: 280 DISLKKNTHTYFYTSFAAYIFGLGLTIFIMHIFKHAQPALLYLVPACIGFPVLVALAKGE 339

Query: 295 LWELW 281
           + E++
Sbjct: 340 VAEMF 344

>DDB1_LYCES (Q6QNU4) DNA damage binding protein 1 (UV-damaged DNA-binding|
           protein 1) (High pigmentation protein 1)
          Length = 1090

 Score = 30.4 bits (67), Expect = 3.2
 Identities = 20/52 (38%), Positives = 28/52 (53%), Gaps = 4/52 (7%)
 Frame = -3

Query: 490 VTVTSD----LSPSSKRRKYVWFALTGYGVGLVTALAAGILSQSPQPALLYL 347
           V VTS+    +S +S+  K  WFA  GY V + TA A  +L  +    L+YL
Sbjct: 462 VQVTSNSVRLVSSTSRDLKNEWFAPVGYSVNVATANATQVLLATGGGHLVYL 513

>DDB1_LYCCS (Q6E7D1) DNA damage binding protein 1 (UV-damaged DNA-binding|
           protein 1)
          Length = 1095

 Score = 30.4 bits (67), Expect = 3.2
 Identities = 20/52 (38%), Positives = 28/52 (53%), Gaps = 4/52 (7%)
 Frame = -3

Query: 490 VTVTSD----LSPSSKRRKYVWFALTGYGVGLVTALAAGILSQSPQPALLYL 347
           V VTS+    +S +S+  K  WFA  GY V + TA A  +L  +    L+YL
Sbjct: 467 VQVTSNSVRLVSSTSRDLKNEWFAPVGYSVNVATANATQVLLATGGGHLVYL 518

>YH2M_CAEEL (Q27533) Probable cation-transporting ATPase W08D2.5 in chromosome|
           IV (EC 3.6.3.-)
          Length = 1256

 Score = 30.0 bits (66), Expect = 4.2
 Identities = 18/56 (32%), Positives = 29/56 (51%), Gaps = 6/56 (10%)
 Frame = -3

Query: 169 CSKLLILQENIYKIVWS**SKPFTLF------LQEEPICNLAVMESVTPYYIW*IF 20
           C  LL + E+ + +  S  S+    +      +Q  PI  L VME +TP+Y++ IF
Sbjct: 142 CRSLLAVSESNFGLTLSEISRRLEFYGRNEIVVQLRPILYLLVMEVITPFYVFQIF 197

>CI079_HUMAN (Q6ZUB1) Protein C9orf79|
          Length = 1445

 Score = 30.0 bits (66), Expect = 4.2
 Identities = 22/79 (27%), Positives = 33/79 (41%), Gaps = 9/79 (11%)
 Frame = +1

Query: 247 EPSRSQLWWILPTAPTDHSSTMTGTQR---------ARVSRAPGRVEQAGETETRSQLPM 399
           +  RSQL+W LP+  ++  +T     R           + +A   +    E E  SQL  
Sbjct: 433 QQKRSQLFWDLPSLNSESLATTVWVSRNPSSQNAHSVPLDKASTSLPGEPEVEASSQLSQ 492

Query: 400 QLPNQHHNLLAQTIHISAA 456
             P  HH  +AQ  H + A
Sbjct: 493 APPQPHH--MAQPQHFTPA 509

>YGCH_ECOLI (Q46897) Hypothetical protein ygcH|
          Length = 199

 Score = 29.3 bits (64), Expect = 7.2
 Identities = 19/60 (31%), Positives = 30/60 (50%)
 Frame = -3

Query: 505 RKSKDVTVTSDLSPSSKRRKYVWFALTGYGVGLVTALAAGILSQSPQPALLYLVPSTLGP 326
           RK  +     D+ P S+R +Y  F+  G    + T    G+L+ +  PAL+ LV   +GP
Sbjct: 128 RKLGNAARVEDVHPISERPQY--FSGDGKSGKIQTVCFEGVLTINDAPALIDLVQQGIGP 185

>DAPA_CHLAB (Q5L5G7) Dihydrodipicolinate synthase (EC 4.2.1.52) (DHDPS)|
          Length = 288

 Score = 28.9 bits (63), Expect = 9.3
 Identities = 14/40 (35%), Positives = 24/40 (60%)
 Frame = -3

Query: 418 GVGLVTALAAGILSQSPQPALLYLVPSTLGPVVYLSWLRN 299
           GV   T     +L+++ +PA+LY +PS  G  +YL  +R+
Sbjct: 107 GVHGQTLWFESLLNKANKPAILYNIPSRSGTTLYLDTVRS 146

>Y996_SYNY3 (P73127) Hypothetical UPF0004 protein sll0996|
          Length = 451

 Score = 28.9 bits (63), Expect = 9.3
 Identities = 18/60 (30%), Positives = 30/60 (50%), Gaps = 3/60 (5%)
 Frame = -3

Query: 406 VTALAAGILSQSPQPALLYLVPS---TLGPVVYLSWLRNDLWELWEGSTTIVNEKAHLLE 236
           +T + AG ++Q     LL  VP     +GP  + + L   L ++W GS  +  E  H++E
Sbjct: 78  LTLVVAGCVAQQEGEQLLRRVPELDLVMGPQ-HANRLDQLLEQVWAGSQVVATESLHIME 136


  Database: uniprot_sprot.fasta
    Posted date:  May 25, 2006  5:36 PM
  Number of letters in database: 80,573,946
  Number of sequences in database:  219,361
  
Lambda     K      H
   0.318    0.135    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 79,419,116
Number of Sequences: 219361
Number of extensions: 1650494
Number of successful extensions: 4059
Number of sequences better than 10.0: 19
Number of HSP's better than 10.0 without gapping: 3943
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4055
length of database: 80,573,946
effective HSP length: 105
effective length of database: 57,541,041
effective search space used: 4142954952
frameshift window, decay const: 50,  0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)