Clone Information

BLAST Search Result

Clone Name	rbags33n12
Clone Library Name	barley_pub

No.	Definition	Score (bits)	E Value
1	HERC3_HUMAN (Q15034) HECT domain and RCC1-like domain protein 3	108	1e-23
2	HERC2_DROME (Q9VR91) HECT domain and RCC1-like domain-containing...	103	6e-22
3	HERC5_HUMAN (Q9UII4) HECT domain and RCC1-like domain-containing...	103	7e-22
4	HERC2_HUMAN (O95714) HECT domain and RCC1-like domain-containing...	102	1e-21
5	HERC2_MOUSE (Q4U2R1) HECT domain and RCC1-like domain-containing...	102	1e-21
6	RCBT2_MOUSE (Q99LJ7) RCC1 and BTB domain-containing protein 2 (R...	97	7e-20
7	RCBT2_RAT (Q6P798) RCC1 and BTB domain-containing protein 2 (Reg...	96	9e-20
8	RCBT2_PONPY (Q5RCZ7) RCC1 and BTB domain-containing protein 2 (R...	95	2e-19
9	RCBT2_HUMAN (O95199) RCC1 and BTB domain-containing protein 2 (R...	95	2e-19
10	RCC2_HUMAN (Q9P258) Protein RCC2 (Telophase disk protein of 60 k...	93	1e-18
11	RCC2_BRARE (Q6NYE2) Protein RCC2 homolog	93	1e-18
12	RCBT1_MOUSE (Q6NXM2) RCC1 and BTB domain-containing protein 1 (R...	92	2e-18
13	RCC2_XENLA (Q52KW8) Protein RCC2 homolog	91	5e-18
14	NEK8_MOUSE (Q91ZR4) Serine/threonine-protein kinase Nek8 (EC 2.7...	89	1e-17
15	RCC2_MOUSE (Q8BK67) Protein RCC2	89	2e-17
16	RCBT1_HUMAN (Q8NDN9) RCC1 and BTB domain-containing protein 1 (R...	88	3e-17
17	GNEFR_HUMAN (Q9UGK8) Guanine nucleotide exchange factor-related ...	87	6e-17
18	RPGR_CANFA (Q9N1T2) X-linked retinitis pigmentosa GTPase regulator	86	1e-16
19	NEK8_HUMAN (Q86SG6) Serine/threonine-protein kinase Nek8 (EC 2.7...	84	4e-16
20	RPGR_MOUSE (Q9R0X5) X-linked retinitis pigmentosa GTPase regulat...	81	4e-15
21	RPGR_HUMAN (Q92834) X-linked retinitis pigmentosa GTPase regulator	79	1e-14
22	RPGRH_CAEEL (Q5DX34) X-linked retinitis pigmentosa GTPase regula...	77	7e-14
23	ALS2_PANTR (Q5BIW4) Alsin (Amyotrophic lateral sclerosis protein...	76	1e-13
24	RCC1_CANAL (P52499) Protein RCC1	76	1e-13
25	ALS2_HUMAN (Q96Q42) Alsin (Amyotrophic lateral sclerosis protein 2)	76	1e-13
26	NEK8_BRARE (Q90XC2) Serine/threonine-protein kinase Nek8 (EC 2.7...	74	5e-13
27	NEK9_XENLA (Q7ZZC8) Serine/threonine-protein kinase Nek9 (EC 2.7...	74	6e-13
28	GNEFR_MOUSE (Q80YD6) Guanine nucleotide exchange factor-related ...	73	8e-13
29	RCC1_SCHPO (P28745) Protein pim1 (Poly(A)+ RNA transport protein 2)	72	2e-12
30	ALS2_MOUSE (Q920R0) Alsin (Amyotrophic lateral sclerosis protein...	72	2e-12
31	RCC1_MESAU (P23800) Regulator of chromosome condensation (Chromo...	71	4e-12
32	NEK9_MOUSE (Q8K1R7) Serine/threonine-protein kinase Nek9 (EC 2.7...	71	4e-12
33	RCC1_HUMAN (P18754) Regulator of chromosome condensation (Chromo...	70	5e-12
34	NEK9_HUMAN (Q8TD19) Serine/threonine-protein kinase Nek9 (EC 2.7...	70	5e-12
35	RCC1_XENLA (P25183) Regulator of chromosome condensation	70	7e-12
36	RCC1_MOUSE (Q8VE37) Regulator of chromosome condensation (Chromo...	70	7e-12
37	HIW_DROME (Q9NB71) Ubiquitin ligase protein highwire (EC 6.3.2.-...	67	8e-11
38	RCC1_DROME (P25171) Regulator of chromosome condensation (Chroma...	66	1e-10
39	RCC1_YEAST (P21827) Regulator of chromosome condensation (PRP20 ...	65	3e-10
40	WBS16_MOUSE (Q9CYF5) Williams-Beuren syndrome chromosome region ...	64	4e-10
41	WBS16_HUMAN (Q96I51) Williams-Beuren syndrome chromosome region ...	63	9e-10
42	MYCB2_HUMAN (O75592) Probable ubiquitin ligase protein MYCBP2 (E...	62	2e-09
43	RPM1_CAEEL (Q17551) Ubiquitin ligase protein rpm-1 (EC 6.3.2.-) ...	60	6e-09
44	MYCB2_MOUSE (Q7TPH6) Probable ubiquitin ligase protein MYCBP2 (E...	58	3e-08
45	ATS1_YEAST (P31386) Protein ATS1 (Alpha-tubulin suppressor 1)	47	5e-05
46	RCC1_CAEEL (Q18211) Regulator of chromosome condensation (Cell c...	43	0.001
47	FBX24_HUMAN (O75426) F-box only protein 24	39	0.013
48	FBX24_MOUSE (Q9D417) F-box only protein 24	38	0.038
49	CRI4_MAIZE (O24585) Putative receptor protein kinase CRINKLY4 pr...	36	0.15
50	YB9W_YEAST (P38352) F-box protein YBR280C	35	0.19
51	POF9_SCHPO (O74381) F-box protein pof9	35	0.32
52	UNC5B_HUMAN (Q8IZJ1) Netrin receptor UNC5B precursor (Unc-5 homo...	34	0.55
53	TKT_SCHPO (Q9URM2) Probable transketolase (EC 2.2.1.1) (TK)	32	1.6

>HERC3_HUMAN (Q15034) HECT domain and RCC1-like domain protein 3|
          Length = 1050

 Score =  108 bits (271), Expect = 1e-23
 Identities = 69/193 (35%), Positives = 99/193 (51%), Gaps = 4/193 (2%)
 Frame = -3

Query: 747 VQGLEQVSMIAV--GAFHNLALSVDRILWAWGNNEYGQLGIGDTQP-RSQPIRVEGLSNL 577
           +Q L Q +++ V  G +H LAL+ D   + WG N +GQLG+G   P ++ P RV  L  +
Sbjct: 131 IQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGI 190

Query: 576 SLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSC 397
            L  +AAGG HS AL+  G V+ WG    G+LG  D+K     P  V+LL  + +V +SC
Sbjct: 191 PLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEKDRES-PCHVKLLRTQKVVYISC 249

Query: 396 GGTHSVVLTSDGRIFSYXXXXXXXXXXXRKVTTGHP-MEVPINLPPPKTSTSSEGLWQAN 220
           G  H+ VLT  G +F++                GH  M   +N   P+      G  +  
Sbjct: 250 GEEHTAVLTKSGGVFTFGAGSCGQL--------GHDSMNDEVN---PRRVLELMGS-EVT 297

Query: 219 YVACGGRHTLAIV 181
            +ACG +HTLA V
Sbjct: 298 QIACGRQHTLAFV 310



 Score = 93.6 bits (231), Expect = 6e-19
 Identities = 53/185 (28%), Positives = 88/185 (47%), Gaps = 1/185 (0%)
 Frame = -3

Query: 735 EQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPR-SQPIRVEGLSNLSLVDIA 559
           + +  +A G  H+LALS    L++WG    GQLG+  T+   + P  ++ L+  +++ ++
Sbjct: 84  QHIIHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQQTILQVS 143

Query: 558 AGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSV 379
            G WH  AL  +G+ + WG+  HG+LG G +  S   P +V+ L G  + QV+ GG HS 
Sbjct: 144 CGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSF 203

Query: 378 VLTSDGRIFSYXXXXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGR 199
            L+  G +F +            +     P  V + L   K            Y++CG  
Sbjct: 204 ALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVKL-LRTQKVV----------YISCGEE 252

Query: 198 HTLAI 184
           HT  +
Sbjct: 253 HTAVL 257



 Score = 90.1 bits (222), Expect = 7e-18
 Identities = 57/180 (31%), Positives = 92/180 (51%), Gaps = 3/180 (1%)
 Frame = -3

Query: 750 RVQGLEQVSM--IAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNL 577
           RV+ LE + +  +A G  H+ ALS+   ++ WG N  GQLG+ D + R  P  V+ L   
Sbjct: 183 RVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLRTQ 242

Query: 576 SLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSC 397
            +V I+ G  H+A LTK G V+ +G G  G+LG  D  +  + P +V  L G ++ Q++C
Sbjct: 243 KVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGH-DSMNDEVNPRRVLELMGSEVTQIAC 301

Query: 396 GGTHSVV-LTSDGRIFSYXXXXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSSEGLWQAN 220
           G  H++  + S G I+++            ++ TGH   V       K  +  +G W A+
Sbjct: 302 GRQHTLAFVPSSGLIYAF------GCGARGQLGTGHTCNV-------KCPSPVKGYWAAH 348



 Score = 85.9 bits (211), Expect = 1e-16
 Identities = 57/182 (31%), Positives = 91/182 (50%)
 Frame = -3

Query: 729 VSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGG 550
           V  +A G  H++ L  D  ++  G N  GQLG    +  ++P ++  L++  ++ +A G 
Sbjct: 36  VKEVACGGNHSVFLLEDGEVYTCGLNTKGQLG--HEREGNKPEQIGALADQHIIHVACGE 93

Query: 549 WHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLT 370
            HS AL+  G++++WG G  G+LG    + S  VP  +Q L  + I+QVSCG  H + L 
Sbjct: 94  SHSLALSDRGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQQTILQVSCGNWHCLALA 153

Query: 369 SDGRIFSYXXXXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGRHTL 190
           +DG+ F++                G   E P    P +   S EG+  A  VA GG H+ 
Sbjct: 154 ADGQFFTWGKNSHG--------QLGLGKEFPSQASPQRV-RSLEGIPLAQ-VAAGGAHSF 203

Query: 189 AI 184
           A+
Sbjct: 204 AL 205



 Score = 63.9 bits (154), Expect = 5e-10
 Identities = 48/162 (29%), Positives = 76/162 (46%), Gaps = 2/162 (1%)
 Frame = -3

Query: 663 WGNNEYGQLGIGDTQPR--SQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEH 490
           WG    GQ GI        ++P     +S+ S+ ++A GG HS  L ++GEVY  G    
Sbjct: 4   WGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGNHSVFLLEDGEVYTCGLNTK 63

Query: 489 GRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXR 310
           G+LG   + +    P Q+  LA + I+ V+CG +HS+ L+  G++FS+            
Sbjct: 64  GQLGHEREGNK---PEQIGALADQHIIHVACGESHSLALSDRGQLFSWGAGSDGQLGL-- 118

Query: 309 KVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGRHTLAI 184
            +TT   + VP  +      T  +       V+CG  H LA+
Sbjct: 119 -MTTEDSVAVPRLIQKLNQQTILQ-------VSCGNWHCLAL 152

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>HERC2_DROME (Q9VR91) HECT domain and RCC1-like domain-containing protein 2|
          Length = 4912

 Score =  103 bits (257), Expect = 6e-22
 Identities = 56/132 (42%), Positives = 82/132 (62%), Gaps = 4/132 (3%)
 Frame = -3

Query: 729  VSMIAV--GAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAA 556
            V  +AV  G  H LAL++D  +++WG  E G+LG G+     +P  VE L    + D+A 
Sbjct: 3073 VKKVAVHSGGKHALALTLDGKVFSWGEGEDGKLGHGNRTTLDKPRLVEALRAKKIRDVAC 3132

Query: 555  GGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGG--THS 382
            G  HSAA++ +GE+Y WG GE+GRLG GD+ ++ + P  V  LAG  +VQV+CG     +
Sbjct: 3133 GSSHSAAISSQGELYTWGLGEYGRLGHGDN-TTQLKPKLVTALAGRRVVQVACGSRDAQT 3191

Query: 381  VVLTSDGRIFSY 346
            + LT DG +FS+
Sbjct: 3192 LALTEDGAVFSW 3203



 Score = 92.0 bits (227), Expect = 2e-18
 Identities = 50/132 (37%), Positives = 76/132 (57%), Gaps = 4/132 (3%)
 Frame = -3

Query: 729  VSMIAV--GAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAA 556
            V  +AV  G  H LAL+ +  ++AWG  E G+LG G+     +P  VE L+ +S+ DIA 
Sbjct: 4136 VKKVAVNSGGKHCLALTTEGEVYAWGEGEDGKLGHGNRMSYDRPKLVEHLNGMSVADIAC 4195

Query: 555  GGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGG--THS 382
            G  HSAA+T  G V  WG+G +GRLG GD +   + P  V+ L G   + ++CG     +
Sbjct: 4196 GSAHSAAITASGHVLTWGKGRYGRLGHGDSE-DQLRPKLVEALLGYRAIDIACGSGDAQT 4254

Query: 381  VVLTSDGRIFSY 346
            + +T D  ++S+
Sbjct: 4255 LCITDDDNVWSW 4266



 Score = 89.7 bits (221), Expect = 9e-18
 Identities = 55/186 (29%), Positives = 93/186 (50%), Gaps = 2/186 (1%)
 Frame = -3

Query: 735  EQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAA 556
            +++  +A G+ H+ A+S    L+ WG  EYG+LG GD   + +P  V  L+   +V +A 
Sbjct: 3125 KKIRDVACGSSHSAAISSQGELYTWGLGEYGRLGHGDNTTQLKPKLVTALAGRRVVQVAC 3184

Query: 555  GG--WHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHS 382
            G     + ALT++G V++WG G+ G+LG G  + S   P +++ L+G  +VQ+ CG   S
Sbjct: 3185 GSRDAQTLALTEDGAVFSWGDGDFGKLGRGGSEGSD-TPHEIERLSGIGVVQIECGAQFS 3243

Query: 381  VVLTSDGRIFSYXXXXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGG 202
            + LT  G ++++                GH  +  +  P P          +  +VA G 
Sbjct: 3244 LALTRAGEVWTWGKGDY--------YRLGHGGDQHVRKPQPIGGLRGR---RVIHVAVGA 3292

Query: 201  RHTLAI 184
             H LA+
Sbjct: 3293 LHCLAV 3298



 Score = 88.2 bits (217), Expect = 2e-17
 Identities = 52/178 (29%), Positives = 83/178 (46%)
 Frame = -3

Query: 711  GAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAAL 532
            G    L ++ D  +W+WG+ +YG+LG G +     P ++E L+ L +V +  G   S AL
Sbjct: 4250 GDAQTLCITDDDNVWSWGDGDYGKLGRGGSDGCKLPYKIESLAGLGVVKVECGSQFSVAL 4309

Query: 531  TKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIF 352
            TK G VY WG+G+  RLG G        P +V  L G+ I+ ++ G  H V  +  G ++
Sbjct: 4310 TKSGAVYTWGKGDFHRLGHGSVDHVRR-PKKVAALQGKKIISIATGSLHCVACSDSGEVY 4368

Query: 351  SYXXXXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGRHTLAIVT 178
            ++            +   G      I  P    +   + + +   V CG  HTLA+ T
Sbjct: 4369 TW--------GDNDEGQLGDGTVTAIQRPRLVAALQGKHIVK---VTCGSAHTLALST 4415



 Score = 87.8 bits (216), Expect = 3e-17
 Identities = 45/130 (34%), Positives = 74/130 (56%), Gaps = 2/130 (1%)
 Frame = -3

Query: 729  VSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGG 550
            V+ IA G+ H+ A++    +  WG   YG+LG GD++ + +P  VE L     +DIA G 
Sbjct: 4190 VADIACGSAHSAAITASGHVLTWGKGRYGRLGHGDSEDQLRPKLVEALLGYRAIDIACGS 4249

Query: 549  WHSAAL--TKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVV 376
              +  L  T +  V++WG G++G+LG G      + P +++ LAG  +V+V CG   SV 
Sbjct: 4250 GDAQTLCITDDDNVWSWGDGDYGKLGRGGSDGCKL-PYKIESLAGLGVVKVECGSQFSVA 4308

Query: 375  LTSDGRIFSY 346
            LT  G ++++
Sbjct: 4309 LTKSGAVYTW 4318



 Score = 85.9 bits (211), Expect = 1e-16
 Identities = 43/131 (32%), Positives = 76/131 (58%), Gaps = 2/131 (1%)
 Frame = -3

Query: 732  QVSMIAVGA--FHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIA 559
            +V  +A G+     LAL+ D  +++WG+ ++G+LG G ++    P  +E LS + +V I 
Sbjct: 3178 RVVQVACGSRDAQTLALTEDGAVFSWGDGDFGKLGRGGSEGSDTPHEIERLSGIGVVQIE 3237

Query: 558  AGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSV 379
             G   S ALT+ GEV+ WG+G++ RLG G D+     P  +  L G  ++ V+ G  H +
Sbjct: 3238 CGAQFSLALTRAGEVWTWGKGDYYRLGHGGDQHVRK-PQPIGGLRGRRVIHVAVGALHCL 3296

Query: 378  VLTSDGRIFSY 346
             +T  G+++++
Sbjct: 3297 AVTDAGQVYAW 3307



 Score = 81.6 bits (200), Expect = 2e-15
 Identities = 50/139 (35%), Positives = 80/139 (57%), Gaps = 4/139 (2%)
 Frame = -3

Query: 750  RVQGLEQ--VSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNL 577
            ++  LEQ  V  +  G  ++ A++    L  WG   Y +LG G++  RS P  V  LS+ 
Sbjct: 661  KIAALEQHCVQSVYCGCSYSAAITCGGNLLTWGRGTYARLGHGNSDDRSLPTLVVALSDH 720

Query: 576  SLVDIAAGGW--HSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQV 403
             +VD+A G    HS ALT EG V+AWG G++G+LG G+   S + P+ V+ L    + +V
Sbjct: 721  MVVDVALGSGDAHSLALTSEGLVFAWGDGDYGKLGNGNCNGS-LQPILVESL--PRVQRV 777

Query: 402  SCGGTHSVVLTSDGRIFSY 346
              G   SV L+S+G+++++
Sbjct: 778  FAGSQFSVALSSEGQLYTW 796



 Score = 75.9 bits (185), Expect = 1e-13
 Identities = 44/123 (35%), Positives = 68/123 (55%), Gaps = 4/123 (3%)
 Frame = -3

Query: 702 HNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKE 523
           H LA+  +   ++WG  E  +LG GDT  R+ P ++  L    +  +  G  +SAA+T  
Sbjct: 627 HFLAIDSNHNAYSWGTGEDHRLGHGDTHARAVPTKIAALEQHCVQSVYCGCSYSAAITCG 686

Query: 522 GEVYAWGRGEHGRLGFG--DDKSSHMVPLQVQLLAGEDIVQVSCGG--THSVVLTSDGRI 355
           G +  WGRG + RLG G  DD+S   +P  V  L+   +V V+ G    HS+ LTS+G +
Sbjct: 687 GNLLTWGRGTYARLGHGNSDDRS---LPTLVVALSDHMVVDVALGSGDAHSLALTSEGLV 743

Query: 354 FSY 346
           F++
Sbjct: 744 FAW 746



 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 43/120 (35%), Positives = 64/120 (53%), Gaps = 3/120 (2%)
 Frame = -3

Query: 729  VSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGG 550
            V  I  GA  +LAL+    +W WG  +Y +LG G  Q   +P  + GL    ++ +A G 
Sbjct: 3233 VVQIECGAQFSLALTRAGEVWTWGKGDYYRLGHGGDQHVRKPQPIGGLRGRRVIHVAVGA 3292

Query: 549  WHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIV---QVSCGGTHSV 379
             H  A+T  G+VYAWG  +HG+ G G+      V  +  L+ G D V   +V+CG +HS+
Sbjct: 3293 LHCLAVTDAGQVYAWGDNDHGQQGSGNT----FVNKKPALVIGLDAVFVNRVACGSSHSI 3348



 Score = 74.3 bits (181), Expect = 4e-13
 Identities = 39/130 (30%), Positives = 70/130 (53%), Gaps = 2/130 (1%)
 Frame = -3

Query: 750  RVQGLEQVSMIAV--GAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNL 577
            +++ L  + ++ V  G+  ++AL+    ++ WG  ++ +LG G      +P +V  L   
Sbjct: 4287 KIESLAGLGVVKVECGSQFSVALTKSGAVYTWGKGDFHRLGHGSVDHVRRPKKVAALQGK 4346

Query: 576  SLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSC 397
             ++ IA G  H  A +  GEVY WG  + G+LG G   ++   P  V  L G+ IV+V+C
Sbjct: 4347 KIISIATGSLHCVACSDSGEVYTWGDNDEGQLGDG-TVTAIQRPRLVAALQGKHIVKVTC 4405

Query: 396  GGTHSVVLTS 367
            G  H++ L++
Sbjct: 4406 GSAHTLALST 4415



 Score = 72.4 bits (176), Expect = 1e-12
 Identities = 42/127 (33%), Positives = 73/127 (57%), Gaps = 2/127 (1%)
 Frame = -3

Query: 720  IAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIA--AGGW 547
            IA G+     +S D  ++A G    G+LG+G T     P ++  L    +  +A  +GG 
Sbjct: 3024 IAGGSKSLFIVSQDGKVYACGEGTNGRLGLGVTHNVPLPHQLPVLRQYVVKKVAVHSGGK 3083

Query: 546  HSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTS 367
            H+ ALT +G+V++WG GE G+LG G ++++   P  V+ L  + I  V+CG +HS  ++S
Sbjct: 3084 HALALTLDGKVFSWGEGEDGKLGHG-NRTTLDKPRLVEALRAKKIRDVACGSSHSAAISS 3142

Query: 366  DGRIFSY 346
             G ++++
Sbjct: 3143 QGELYTW 3149



 Score = 70.5 bits (171), Expect = 5e-12
 Identities = 43/123 (34%), Positives = 64/123 (52%), Gaps = 1/123 (0%)
 Frame = -3

Query: 711  GAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAAL 532
            G  H+LAL+ + +++AWG+ +YG+LG G+     QPI VE L  +  V   AG   S AL
Sbjct: 730  GDAHSLALTSEGLVFAWGDGDYGKLGNGNCNGSLQPILVESLPRVQRV--FAGSQFSVAL 787

Query: 531  TKEGEVYAWGRGE-HGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRI 355
            + EG++Y WG+    G            VP  V  L  + IV V+    H + L+S G +
Sbjct: 788  SSEGQLYTWGKATCLGHQLVERSVQGCSVPRLVSSLQHKRIVDVAVSVAHCLALSSSGEV 847

Query: 354  FSY 346
            F +
Sbjct: 848  FGW 850



 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 50/165 (30%), Positives = 78/165 (47%), Gaps = 2/165 (1%)
 Frame = -3

Query: 672  LWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGE 493
            ++ WG+N  GQLG  +      P   E LS L  V +A G     A+T +G+++A G G 
Sbjct: 4051 IYGWGHNHRGQLGGLEGSRIKTPTPCEALSLLRPVQLAGGEQSLFAVTPDGKLFATGYGS 4110

Query: 492  HGRLGFGDDKSSHMVPLQVQLLAGEDI--VQVSCGGTHSVVLTSDGRIFSYXXXXXXXXX 319
             GRLG G    S  +P  +  L    +  V V+ GG H + LT++G ++++         
Sbjct: 4111 GGRLGVG-GSDSWAIPTLLGSLQHVFVKKVAVNSGGKHCLALTTEGEVYAW------GEG 4163

Query: 318  XXRKVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGRHTLAI 184
               K+  G+ M    +   PK      G+  A+ +ACG  H+ AI
Sbjct: 4164 EDGKLGHGNRM----SYDRPKLVEHLNGMSVAD-IACGSAHSAAI 4203



 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 50/164 (30%), Positives = 70/164 (42%), Gaps = 4/164 (2%)
 Frame = -3

Query: 663  WGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGR 484
            WG N+  QLG         P   + +S L  + IA G      ++++G+VYA G G +GR
Sbjct: 2991 WGLNDKEQLGGLKGSKVKVPTFSQTISRLRPIHIAGGSKSLFIVSQDGKVYACGEGTNGR 3050

Query: 483  LGFGDDKSSHMVPLQVQLLAGEDI----VQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXX 316
            LG G    +H VPL  QL          V V  GG H++ LT DG++FS+          
Sbjct: 3051 LGLG---VTHNVPLPHQLPVLRQYVVKKVAVHSGGKHALALTLDGKVFSWGEGEDGKLGH 3107

Query: 315  XRKVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGRHTLAI 184
              + T   P  V            +    +   VACG  H+ AI
Sbjct: 3108 GNRTTLDKPRLV-----------EALRAKKIRDVACGSSHSAAI 3140



 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 34/131 (25%), Positives = 59/131 (45%), Gaps = 2/131 (1%)
 Frame = -3

Query: 732 QVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAG 553
           Q+  +A      L LS +  L+ W             +P ++P+ +E +++   + IA  
Sbjct: 573 QIKQVACCETQMLILSQEGKLYTWRL----------AKPEAEPLPMEEVAHDVFISIAGH 622

Query: 552 --GWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSV 379
             G H  A+      Y+WG GE  RLG G D  +  VP ++  L    +  V CG ++S 
Sbjct: 623 CEGRHFLAIDSNHNAYSWGTGEDHRLGHG-DTHARAVPTKIAALEQHCVQSVYCGCSYSA 681

Query: 378 VLTSDGRIFSY 346
            +T  G + ++
Sbjct: 682 AITCGGNLLTW 692



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 26/66 (39%), Positives = 40/66 (60%)
 Frame = -3

Query: 732  QVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAG 553
            +V  +AVGA H LA++    ++AWG+N++GQ G G+T    +P  V GL  + +  +A G
Sbjct: 3284 RVIHVAVGALHCLAVTDAGQVYAWGDNDHGQQGSGNTFVNKKPALVIGLDAVFVNRVACG 3343

Query: 552  GWHSAA 535
              HS A
Sbjct: 3344 SSHSIA 3349



 Score = 47.0 bits (110), Expect = 6e-05
 Identities = 29/87 (33%), Positives = 43/87 (49%), Gaps = 2/87 (2%)
 Frame = -3

Query: 747  VQGLEQVSMIAVGAFHNLALSVDRILWAWGNNEY--GQLGIGDTQPRSQPIRVEGLSNLS 574
            V+ L +V  +  G+  ++ALS +  L+ WG       QL     Q  S P  V  L +  
Sbjct: 768  VESLPRVQRVFAGSQFSVALSSEGQLYTWGKATCLGHQLVERSVQGCSVPRLVSSLQHKR 827

Query: 573  LVDIAAGGWHSAALTKEGEVYAWGRGE 493
            +VD+A    H  AL+  GEV+ WGR +
Sbjct: 828  IVDVAVSVAHCLALSSSGEVFGWGRND 854

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>HERC5_HUMAN (Q9UII4) HECT domain and RCC1-like domain-containing protein 5|
           (Cyclin-E-binding protein 1)
          Length = 1024

 Score =  103 bits (256), Expect = 7e-22
 Identities = 49/129 (37%), Positives = 82/129 (63%), Gaps = 1/129 (0%)
 Frame = -3

Query: 729 VSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGG 550
           ++ I+ G  H++ALS+   +++WG NE GQLG+G T+ +  P  +EGL N  +  +A GG
Sbjct: 193 LAQISAGEAHSMALSMSGNIYSWGKNECGQLGLGHTESKDDPSLIEGLDNQKVEFVACGG 252

Query: 549 WHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLT 370
            HSA LT++G ++ +G G+HG+LG  +   + + P  V  L G  + Q++CG  H++   
Sbjct: 253 SHSALLTQDGLLFTFGAGKHGQLGH-NSTQNELRPCLVAELVGYRVTQIACGRWHTLAYV 311

Query: 369 SD-GRIFSY 346
           SD G++FS+
Sbjct: 312 SDLGKVFSF 320



 Score =  101 bits (252), Expect = 2e-21
 Identities = 63/187 (33%), Positives = 96/187 (51%), Gaps = 1/187 (0%)
 Frame = -3

Query: 735 EQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQP-RSQPIRVEGLSNLSLVDIA 559
           +++  I  G +H+LALS    L+AWG N +GQLG+G   P  + P  VE L+ + L  I+
Sbjct: 138 KKIIQITCGDYHSLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVPLAQIS 197

Query: 558 AGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSV 379
           AG  HS AL+  G +Y+WG+ E G+LG G  +S    P  ++ L  + +  V+CGG+HS 
Sbjct: 198 AGEAHSMALSMSGNIYSWGKNECGQLGLGHTESKD-DPSLIEGLDNQKVEFVACGGSHSA 256

Query: 378 VLTSDGRIFSYXXXXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGR 199
           +LT DG +F++                  P  V   +            ++   +ACG  
Sbjct: 257 LLTQDGLLFTFGAGKHGQLGHNSTQNELRPCLVAELVG-----------YRVTQIACGRW 305

Query: 198 HTLAIVT 178
           HTLA V+
Sbjct: 306 HTLAYVS 312



 Score = 72.4 bits (176), Expect = 1e-12
 Identities = 54/182 (29%), Positives = 80/182 (43%), Gaps = 2/182 (1%)
 Frame = -3

Query: 732 QVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAG 553
           ++  +  GA H L LS D   + + N     L       R + I    L    ++ I  G
Sbjct: 98  KIHSVDQGAEHMLILSSDGKPFEYDNYSMKHL-------RFESI----LQEKKIIQITCG 146

Query: 552 GWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVL 373
            +HS AL+K GE++AWG+  HG+LG G    S   P  V+ LAG  + Q+S G  HS+ L
Sbjct: 147 DYHSLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVPLAQISAGEAHSMAL 206

Query: 372 TSDGRIFSYXXXXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSSEGL--WQANYVACGGR 199
           +  G I+S+              +   P  +             EGL   +  +VACGG 
Sbjct: 207 SMSGNIYSWGKNECGQLGLGHTESKDDPSLI-------------EGLDNQKVEFVACGGS 253

Query: 198 HT 193
           H+
Sbjct: 254 HS 255



 Score = 68.9 bits (167), Expect = 2e-11
 Identities = 39/132 (29%), Positives = 73/132 (55%), Gaps = 3/132 (2%)
 Frame = -3

Query: 747 VQGLE--QVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLS 574
           ++GL+  +V  +A G  H+  L+ D +L+ +G  ++GQLG   TQ   +P  V  L    
Sbjct: 237 IEGLDNQKVEFVACGGSHSALLTQDGLLFTFGAGKHGQLGHNSTQNELRPCLVAELVGYR 296

Query: 573 LVDIAAGGWHSAALTKE-GEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSC 397
           +  IA G WH+ A   + G+V+++G G+ G+LG G  +   ++PL V++ + E++   S 
Sbjct: 297 VTQIACGRWHTLAYVSDLGKVFSFGSGKDGQLGNGGTR-DQLMPLPVKVSSSEELKLESH 355

Query: 396 GGTHSVVLTSDG 361
                +++ + G
Sbjct: 356 TSEKELIMIAGG 367

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>HERC2_HUMAN (O95714) HECT domain and RCC1-like domain-containing protein 2|
          Length = 4834

 Score =  102 bits (254), Expect = 1e-21
 Identities = 58/175 (33%), Positives = 89/175 (50%)
 Frame = -3

Query: 711  GAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAAL 532
            G    L L+ D  +W+WG+ +YG+LG G +     P++++ L+ L +V +  G   S AL
Sbjct: 4153 GDAQTLCLTDDDTVWSWGDGDYGKLGRGGSDGCKVPMKIDSLTGLGVVKVECGSQFSVAL 4212

Query: 531  TKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIF 352
            TK G VY WG+G++ RLG G D      P QVQ L G+ ++ ++ G  H V  T DG ++
Sbjct: 4213 TKSGAVYTWGKGDYHRLGHGSDDHVRR-PRQVQGLQGKKVIAIATGSLHCVCCTEDGEVY 4271

Query: 351  SYXXXXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGRHTLA 187
            ++              TT         +  P+   + +G  + N VACG  HTLA
Sbjct: 4272 TWGDNDEGQLGDG---TTN-------AIQRPRLVAALQGK-KVNRVACGSAHTLA 4315



 Score =  100 bits (249), Expect = 5e-21
 Identities = 65/194 (33%), Positives = 99/194 (51%), Gaps = 8/194 (4%)
 Frame = -3

Query: 729  VSMIAV--GAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAA 556
            V  +AV  G  H  AL+VD  +++WG  + G+LG        +P  +E L    + DIA 
Sbjct: 3047 VKKVAVHSGGRHATALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIAC 3106

Query: 555  GGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGG--THS 382
            G  HSAALT  GE+Y WG GE+GRLG GD+ ++ + P  V++L G  ++QV+CG     +
Sbjct: 3107 GSSHSAALTSSGELYTWGLGEYGRLGHGDN-TTQLKPKMVKVLLGHRVIQVACGSRDAQT 3165

Query: 381  VVLTSDGRIFSYXXXXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGG 202
            + LT +G +FS+                G       N+P      + +G+ Q   + CG 
Sbjct: 3166 LALTDEGLVFSWGDGDFG--------KLGRGGSEGCNIPQNIERLNGQGVCQ---IECGA 3214

Query: 201  RHTLAI----VTWT 172
            + +LA+    V WT
Sbjct: 3215 QFSLALTKSGVVWT 3228



 Score = 97.1 bits (240), Expect = 5e-20
 Identities = 48/124 (38%), Positives = 75/124 (60%), Gaps = 2/124 (1%)
 Frame = -3

Query: 711  GAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAAL 532
            G  H LALS +  +++WG  E G+LG G+  P  +P  +E L  + +VD+AAGG HSA +
Sbjct: 4047 GGKHCLALSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIESLRGIEVVDVAAGGAHSACV 4106

Query: 531  TKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGG--THSVVLTSDGR 358
            T  G++Y WG+G +GRLG  D +   + P  V+ L G  +V ++CG     ++ LT D  
Sbjct: 4107 TAAGDLYTWGKGRYGRLGHSDSE-DQLKPKLVEALQGHRVVDIACGSGDAQTLCLTDDDT 4165

Query: 357  IFSY 346
            ++S+
Sbjct: 4166 VWSW 4169



 Score = 97.1 bits (240), Expect = 5e-20
 Identities = 52/161 (32%), Positives = 87/161 (54%), Gaps = 4/161 (2%)
 Frame = -3

Query: 747  VQGLEQVSMIAV----GAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSN 580
            V GL+ + +I V    G    LA++ +  +W+WG+ +YG+LG G +     P  +E L +
Sbjct: 597  VAGLKGLKVIDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQD 656

Query: 579  LSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVS 400
            L +V +  G   S ALTK+G+VY+WG+G++ RLG G ++     P  ++ L G+ ++ V+
Sbjct: 657  LDVVKVRCGSQFSIALTKDGQVYSWGKGDNQRLGHGTEEHVR-YPKLLEGLQGKKVIDVA 715

Query: 399  CGGTHSVVLTSDGRIFSYXXXXXXXXXXXRKVTTGHPMEVP 277
             G TH + LT D  + S+            +VT   P  +P
Sbjct: 716  AGSTHCLALTEDSEVHSWGSNDQCQHFDTLRVTKPEPAALP 756



 Score = 94.4 bits (233), Expect = 3e-19
 Identities = 46/135 (34%), Positives = 80/135 (59%), Gaps = 2/135 (1%)
 Frame = -3

Query: 744 QGLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVD 565
           Q  + V  IA G+ ++ A++ +  L+ WG   YG+LG G ++  + P+ V GL  L ++D
Sbjct: 548 QAGKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVID 607

Query: 564 IAAGGW--HSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGG 391
           +A G     + A+T+ G+V++WG G++G+LG G        P  ++ L   D+V+V CG 
Sbjct: 608 VACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDGC-KTPKLIEKLQDLDVVKVRCGS 666

Query: 390 THSVVLTSDGRIFSY 346
             S+ LT DG+++S+
Sbjct: 667 QFSIALTKDGQVYSW 681



 Score = 90.9 bits (224), Expect = 4e-18
 Identities = 51/144 (35%), Positives = 82/144 (56%), Gaps = 10/144 (6%)
 Frame = -3

Query: 747 VQGLEQVSMIAVGAF----HNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSN 580
           VQGL   +++ + A     H LAL+    +++WG  + G+LG GDT P  +P  +   S 
Sbjct: 487 VQGLASRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSG 546

Query: 579 LS----LVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDI 412
                 +V IA G  +SAA+T EGE+Y WGRG +GRLG G  +    +P+ V  L G  +
Sbjct: 547 KQAGKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSE-DEAIPMLVAGLKGLKV 605

Query: 411 VQVSCGG--THSVVLTSDGRIFSY 346
           + V+CG     ++ +T +G+++S+
Sbjct: 606 IDVACGSGDAQTLAVTENGQVWSW 629



 Score = 90.5 bits (223), Expect = 5e-18
 Identities = 48/121 (39%), Positives = 68/121 (56%)
 Frame = -3

Query: 729  VSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGG 550
            V  I  GA  +LAL+   ++W WG  +Y +LG G      +P  VEGL    +V +A G 
Sbjct: 3207 VCQIECGAQFSLALTKSGVVWTWGKGDYFRLGHGSDVHVRKPQVVEGLRGKKIVHVAVGA 3266

Query: 549  WHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLT 370
             H  A+T  G+VYAWG  +HG+ G G   + +  P  VQ L G+ I +V+CG +HSV  T
Sbjct: 3267 LHCLAVTDSGQVYAWGDNDHGQQGNG-TTTVNRKPTLVQGLEGQKITRVACGSSHSVAWT 3325

Query: 369  S 367
            +
Sbjct: 3326 T 3326



 Score = 87.0 bits (214), Expect = 6e-17
 Identities = 47/136 (34%), Positives = 77/136 (56%), Gaps = 2/136 (1%)
 Frame = -3

Query: 747  VQGLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLV 568
            ++G+E V + A GA H+  ++    L+ WG   YG+LG  D++ + +P  VE L    +V
Sbjct: 4088 LRGIEVVDVAAGGA-HSACVTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQGHRVV 4146

Query: 567  DIAAGGW--HSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCG 394
            DIA G     +  LT +  V++WG G++G+LG G       VP+++  L G  +V+V CG
Sbjct: 4147 DIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRGGSDGC-KVPMKIDSLTGLGVVKVECG 4205

Query: 393  GTHSVVLTSDGRIFSY 346
               SV LT  G ++++
Sbjct: 4206 SQFSVALTKSGAVYTW 4221



 Score = 86.3 bits (212), Expect = 9e-17
 Identities = 54/186 (29%), Positives = 92/186 (49%), Gaps = 2/186 (1%)
 Frame = -3

Query: 735  EQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAA 556
            +++  IA G+ H+ AL+    L+ WG  EYG+LG GD   + +P  V+ L    ++ +A 
Sbjct: 3099 KRIRDIACGSSHSAALTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVAC 3158

Query: 555  GG--WHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHS 382
            G     + ALT EG V++WG G+ G+LG G  +  + +P  ++ L G+ + Q+ CG   S
Sbjct: 3159 GSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEGCN-IPQNIERLNGQGVCQIECGAQFS 3217

Query: 381  VVLTSDGRIFSYXXXXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGG 202
            + LT  G ++++                GH  +V +  P        +   +  +VA G 
Sbjct: 3218 LALTKSGVVWTWGKGDY--------FRLGHGSDVHVRKPQVVEGLRGK---KIVHVAVGA 3266

Query: 201  RHTLAI 184
             H LA+
Sbjct: 3267 LHCLAV 3272



 Score = 82.0 bits (201), Expect = 2e-15
 Identities = 54/189 (28%), Positives = 91/189 (48%), Gaps = 4/189 (2%)
 Frame = -3

Query: 732  QVSMIAVGA--FHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIA 559
            +V  +A G+     LAL+ + ++++WG+ ++G+LG G ++  + P  +E L+   +  I 
Sbjct: 3152 RVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIE 3211

Query: 558  AGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSV 379
             G   S ALTK G V+ WG+G++ RLG G D      P  V+ L G+ IV V+ G  H +
Sbjct: 3212 CGAQFSLALTKSGVVWTWGKGDYFRLGHGSDVHVRK-PQVVEGLRGKKIVHVAVGALHCL 3270

Query: 378  VLTSDGRIFSYXXXXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSSEGL--WQANYVACG 205
             +T  G+++++                  P             T  +GL   +   VACG
Sbjct: 3271 AVTDSGQVYAWGDNDHGQQGNGTTTVNRKP-------------TLVQGLEGQKITRVACG 3317

Query: 204  GRHTLAIVT 178
              H++A  T
Sbjct: 3318 SSHSVAWTT 3326



 Score = 74.3 bits (181), Expect = 4e-13
 Identities = 37/117 (31%), Positives = 62/117 (52%)
 Frame = -3

Query: 729  VSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGG 550
            V  +  G+  ++AL+    ++ WG  +Y +LG G      +P +V+GL    ++ IA G 
Sbjct: 4199 VVKVECGSQFSVALTKSGAVYTWGKGDYHRLGHGSDDHVRRPRQVQGLQGKKVIAIATGS 4258

Query: 549  WHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSV 379
             H    T++GEVY WG  + G+LG G   +    P  V  L G+ + +V+CG  H++
Sbjct: 4259 LHCVCCTEDGEVYTWGDNDEGQLGDGTTNAIQR-PRLVAALQGKKVNRVACGSAHTL 4314



 Score = 69.7 bits (169), Expect = 9e-12
 Identities = 50/174 (28%), Positives = 78/174 (44%), Gaps = 2/174 (1%)
 Frame = -3

Query: 693  ALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEV 514
            A ++   ++ WG N+  QLG         P   E LS L++V +A G     A+T EG+V
Sbjct: 2954 AATIRTKVFVWGLNDKDQLGGLKGSKIKVPSFSETLSALNVVQVAGGSKSLFAVTVEGKV 3013

Query: 513  YAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDI--VQVSCGGTHSVVLTSDGRIFSYXX 340
            YA G   +GRLG G    +  +P Q+  L+   +  V V  GG H+  LT DG++FS+  
Sbjct: 3014 YACGEATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFSWGE 3073

Query: 339  XXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGRHTLAIVT 178
                      ++    P  +       KT    +       +ACG  H+ A+ +
Sbjct: 3074 GDDGKLGHFSRMNCDKPRLI----EALKTKRIRD-------IACGSSHSAALTS 3116



 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 37/97 (38%), Positives = 58/97 (59%), Gaps = 10/97 (10%)
 Frame = -3

Query: 606 PIRVEGLSNLSLVDIAA--GGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQ 433
           P  V+GL++ ++V IAA   G H  AL   GEVY+WG G+ GRLG GD      VPL+  
Sbjct: 484 PQLVQGLASRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGD-----TVPLEEP 538

Query: 432 LL--------AGEDIVQVSCGGTHSVVLTSDGRIFSY 346
            +        AG+ +V ++CG T+S  +T++G ++++
Sbjct: 539 KVISAFSGKQAGKHVVHIACGSTYSAAITAEGELYTW 575



 Score = 63.2 bits (152), Expect = 9e-10
 Identities = 43/163 (26%), Positives = 70/163 (42%), Gaps = 54/163 (33%)
 Frame = -3

Query: 672  LWAWGNNEYGQ------------------------------------------------- 640
            ++ WG+N  GQ                                                 
Sbjct: 3954 IYGWGHNHRGQLGGIEGAKVKVPTPCEALATLRPVQLIGGEQTLFAVTADGKLYATGYGA 4013

Query: 639  ---LGIGDTQPRSQPIRVEGLSNLSLVDIA--AGGWHSAALTKEGEVYAWGRGEHGRLGF 475
               LGIG T+  S P  +E + ++ +  +A  +GG H  AL+ EGEVY+WG  E G+LG 
Sbjct: 4014 GGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAEDGKLGH 4073

Query: 474  GDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSY 346
            G ++S    P  ++ L G ++V V+ GG HS  +T+ G ++++
Sbjct: 4074 G-NRSPCDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTW 4115



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 29/75 (38%), Positives = 45/75 (60%), Gaps = 2/75 (2%)
 Frame = -3

Query: 747  VQGL--EQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLS 574
            V+GL  +++  +AVGA H LA++    ++AWG+N++GQ G G T    +P  V+GL    
Sbjct: 3251 VEGLRGKKIVHVAVGALHCLAVTDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQK 3310

Query: 573  LVDIAAGGWHSAALT 529
            +  +A G  HS A T
Sbjct: 3311 ITRVACGSSHSVAWT 3325



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 26/74 (35%), Positives = 40/74 (54%), Gaps = 2/74 (2%)
 Frame = -3

Query: 750  RVQGLE--QVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNL 577
            +VQGL+  +V  IA G+ H +  + D  ++ WG+N+ GQLG G T    +P  V  L   
Sbjct: 4242 QVQGLQGKKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQLGDGTTNAIQRPRLVAALQGK 4301

Query: 576  SLVDIAAGGWHSAA 535
             +  +A G  H+ A
Sbjct: 4302 KVNRVACGSAHTLA 4315

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>HERC2_MOUSE (Q4U2R1) HECT domain and RCC1-like domain-containing protein 2|
          Length = 4836

 Score =  102 bits (254), Expect = 1e-21
 Identities = 58/175 (33%), Positives = 89/175 (50%)
 Frame = -3

Query: 711  GAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAAL 532
            G    L L+ D  +W+WG+ +YG+LG G +     P++++ L+ L +V +  G   S AL
Sbjct: 4155 GDAQTLCLTDDDTVWSWGDGDYGKLGRGGSDGCKVPMKIDSLTGLGVVKVECGSQFSVAL 4214

Query: 531  TKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIF 352
            TK G VY WG+G++ RLG G D      P QVQ L G+ ++ ++ G  H V  T DG ++
Sbjct: 4215 TKSGAVYTWGKGDYHRLGHGSDDHVRR-PRQVQGLQGKKVIAIATGSLHCVCCTEDGEVY 4273

Query: 351  SYXXXXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGRHTLA 187
            ++              TT         +  P+   + +G  + N VACG  HTLA
Sbjct: 4274 TWGDNDEGQLGDG---TTN-------AIQRPRLVAALQGK-KVNRVACGSAHTLA 4317



 Score = 96.7 bits (239), Expect = 7e-20
 Identities = 47/124 (37%), Positives = 75/124 (60%), Gaps = 2/124 (1%)
 Frame = -3

Query: 711  GAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAAL 532
            G  H LALS +  +++WG  E G+LG G+  P  +P  +E L  + +VD+AAGG HSA +
Sbjct: 4049 GGKHCLALSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIESLRGIEVVDVAAGGAHSACV 4108

Query: 531  TKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGG--THSVVLTSDGR 358
            T  G++Y WG+G +GRLG  D +   + P  V+ L G  ++ ++CG     ++ LT D  
Sbjct: 4109 TAAGDLYTWGKGRYGRLGHSDSE-DQLKPKLVEALQGHRVIDIACGSGDAQTLCLTDDDT 4167

Query: 357  IFSY 346
            ++S+
Sbjct: 4168 VWSW 4171



 Score = 96.7 bits (239), Expect = 7e-20
 Identities = 63/194 (32%), Positives = 98/194 (50%), Gaps = 8/194 (4%)
 Frame = -3

Query: 729  VSMIAV--GAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAA 556
            V  +AV  G  H  AL+VD  +++WG  + G+LG        +P  ++ L    + DIA 
Sbjct: 3048 VKKVAVHSGGRHATALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIQALKTKRIRDIAY 3107

Query: 555  GGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGG--THS 382
            G  HSA LT  GE+Y WG GE+GRLG GD+ ++ + P  V++L G  ++QV+CG     +
Sbjct: 3108 GSSHSAPLTSSGELYTWGLGEYGRLGHGDN-TTQLKPKMVKVLLGHRVIQVACGSRDAQT 3166

Query: 381  VVLTSDGRIFSYXXXXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGG 202
            + LT +G +FS+                G       N+P      + +G+ Q   + CG 
Sbjct: 3167 LALTDEGLVFSWGDGDFG--------KLGRGGSEGCNIPQNIERLNGQGVCQ---IECGA 3215

Query: 201  RHTLAI----VTWT 172
            + +LA+    V WT
Sbjct: 3216 QFSLALTKSGVVWT 3229



 Score = 95.9 bits (237), Expect = 1e-19
 Identities = 52/161 (32%), Positives = 86/161 (53%), Gaps = 4/161 (2%)
 Frame = -3

Query: 747  VQGLEQVSMIAV----GAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSN 580
            V GL+ + +I V    G    LA++ +  +W+WG+ +YG+LG G +     P  +E L +
Sbjct: 598  VAGLKGLKVIDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQD 657

Query: 579  LSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVS 400
            L ++ +  G   S ALTK+G+VY+WG+G++ RLG G ++     P  ++ L G+ ++ V+
Sbjct: 658  LDVIKVRCGSQFSIALTKDGQVYSWGKGDNQRLGHGTEEHVR-YPKLLEGLQGKKVIDVA 716

Query: 399  CGGTHSVVLTSDGRIFSYXXXXXXXXXXXRKVTTGHPMEVP 277
             G TH +VLT D  + S+             VT   P   P
Sbjct: 717  AGSTHCLVLTEDSEVHSWGSNDQCQHFDTLGVTKPEPTAFP 757



 Score = 94.0 bits (232), Expect = 5e-19
 Identities = 45/135 (33%), Positives = 80/135 (59%), Gaps = 2/135 (1%)
 Frame = -3

Query: 744 QGLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVD 565
           Q  + V  IA G+ ++ A++ +  L+ WG   YG+LG G ++  + P+ V GL  L ++D
Sbjct: 549 QAGKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVID 608

Query: 564 IAAGGW--HSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGG 391
           +A G     + A+T+ G+V++WG G++G+LG G        P  ++ L   D+++V CG 
Sbjct: 609 VACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDGC-KTPKLIEKLQDLDVIKVRCGS 667

Query: 390 THSVVLTSDGRIFSY 346
             S+ LT DG+++S+
Sbjct: 668 QFSIALTKDGQVYSW 682



 Score = 90.9 bits (224), Expect = 4e-18
 Identities = 51/144 (35%), Positives = 82/144 (56%), Gaps = 10/144 (6%)
 Frame = -3

Query: 747 VQGLEQVSMIAVGAF----HNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSN 580
           VQGL   +++ + A     H LAL+    +++WG  + G+LG GDT P  +P  +   S 
Sbjct: 488 VQGLASRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSG 547

Query: 579 LS----LVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDI 412
                 +V IA G  +SAA+T EGE+Y WGRG +GRLG G  +    +P+ V  L G  +
Sbjct: 548 KQAGKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSE-DEAIPMLVAGLKGLKV 606

Query: 411 VQVSCGG--THSVVLTSDGRIFSY 346
           + V+CG     ++ +T +G+++S+
Sbjct: 607 IDVACGSGDAQTLAVTENGQVWSW 630



 Score = 90.5 bits (223), Expect = 5e-18
 Identities = 48/121 (39%), Positives = 68/121 (56%)
 Frame = -3

Query: 729  VSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGG 550
            V  I  GA  +LAL+   ++W WG  +Y +LG G      +P  VEGL    +V +A G 
Sbjct: 3208 VCQIECGAQFSLALTKSGVVWTWGKGDYFRLGHGSDVHVRKPQVVEGLRGKKIVHVAVGA 3267

Query: 549  WHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLT 370
             H  A+T  G+VYAWG  +HG+ G G   + +  P  VQ L G+ I +V+CG +HSV  T
Sbjct: 3268 LHCLAVTDSGQVYAWGDNDHGQQGNG-TTTVNRKPTLVQGLEGQKITRVACGSSHSVAWT 3326

Query: 369  S 367
            +
Sbjct: 3327 T 3327



 Score = 86.7 bits (213), Expect = 7e-17
 Identities = 46/136 (33%), Positives = 77/136 (56%), Gaps = 2/136 (1%)
 Frame = -3

Query: 747  VQGLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLV 568
            ++G+E V + A GA H+  ++    L+ WG   YG+LG  D++ + +P  VE L    ++
Sbjct: 4090 LRGIEVVDVAAGGA-HSACVTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQGHRVI 4148

Query: 567  DIAAGGW--HSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCG 394
            DIA G     +  LT +  V++WG G++G+LG G       VP+++  L G  +V+V CG
Sbjct: 4149 DIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRGGSDGC-KVPMKIDSLTGLGVVKVECG 4207

Query: 393  GTHSVVLTSDGRIFSY 346
               SV LT  G ++++
Sbjct: 4208 SQFSVALTKSGAVYTW 4223



 Score = 84.3 bits (207), Expect = 4e-16
 Identities = 53/186 (28%), Positives = 91/186 (48%), Gaps = 2/186 (1%)
 Frame = -3

Query: 735  EQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAA 556
            +++  IA G+ H+  L+    L+ WG  EYG+LG GD   + +P  V+ L    ++ +A 
Sbjct: 3100 KRIRDIAYGSSHSAPLTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVAC 3159

Query: 555  GG--WHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHS 382
            G     + ALT EG V++WG G+ G+LG G  +  + +P  ++ L G+ + Q+ CG   S
Sbjct: 3160 GSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEGCN-IPQNIERLNGQGVCQIECGAQFS 3218

Query: 381  VVLTSDGRIFSYXXXXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGG 202
            + LT  G ++++                GH  +V +  P        +   +  +VA G 
Sbjct: 3219 LALTKSGVVWTWGKGDY--------FRLGHGSDVHVRKPQVVEGLRGK---KIVHVAVGA 3267

Query: 201  RHTLAI 184
             H LA+
Sbjct: 3268 LHCLAV 3273



 Score = 82.0 bits (201), Expect = 2e-15
 Identities = 54/189 (28%), Positives = 91/189 (48%), Gaps = 4/189 (2%)
 Frame = -3

Query: 732  QVSMIAVGA--FHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIA 559
            +V  +A G+     LAL+ + ++++WG+ ++G+LG G ++  + P  +E L+   +  I 
Sbjct: 3153 RVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIE 3212

Query: 558  AGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSV 379
             G   S ALTK G V+ WG+G++ RLG G D      P  V+ L G+ IV V+ G  H +
Sbjct: 3213 CGAQFSLALTKSGVVWTWGKGDYFRLGHGSDVHVRK-PQVVEGLRGKKIVHVAVGALHCL 3271

Query: 378  VLTSDGRIFSYXXXXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSSEGL--WQANYVACG 205
             +T  G+++++                  P             T  +GL   +   VACG
Sbjct: 3272 AVTDSGQVYAWGDNDHGQQGNGTTTVNRKP-------------TLVQGLEGQKITRVACG 3318

Query: 204  GRHTLAIVT 178
              H++A  T
Sbjct: 3319 SSHSVAWTT 3327



 Score = 74.3 bits (181), Expect = 4e-13
 Identities = 37/117 (31%), Positives = 62/117 (52%)
 Frame = -3

Query: 729  VSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGG 550
            V  +  G+  ++AL+    ++ WG  +Y +LG G      +P +V+GL    ++ IA G 
Sbjct: 4201 VVKVECGSQFSVALTKSGAVYTWGKGDYHRLGHGSDDHVRRPRQVQGLQGKKVIAIATGS 4260

Query: 549  WHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSV 379
             H    T++GEVY WG  + G+LG G   +    P  V  L G+ + +V+CG  H++
Sbjct: 4261 LHCVCCTEDGEVYTWGDNDEGQLGDGTTNAIQR-PRLVAALQGKKVNRVACGSAHTL 4316



 Score = 67.8 bits (164), Expect = 3e-11
 Identities = 40/111 (36%), Positives = 59/111 (53%), Gaps = 2/111 (1%)
 Frame = -3

Query: 672  LWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGE 493
            ++ WG N+  QLG         P   E LS L++V +A G     A+T EG+VY+ G   
Sbjct: 2962 VFVWGLNDKDQLGGLKGSKIKVPSFSETLSALNVVQVAGGSKSLFAVTVEGKVYSCGEAT 3021

Query: 492  HGRLGFGDDKSSHMVPLQVQLLAGEDI--VQVSCGGTHSVVLTSDGRIFSY 346
            +GRLG G    +  +P Q+  L+   +  V V  GG H+  LT DG++FS+
Sbjct: 3022 NGRLGLGMSSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFSW 3072



 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 37/97 (38%), Positives = 58/97 (59%), Gaps = 10/97 (10%)
 Frame = -3

Query: 606 PIRVEGLSNLSLVDIAA--GGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQ 433
           P  V+GL++ ++V IAA   G H  AL   GEVY+WG G+ GRLG GD      VPL+  
Sbjct: 485 PQLVQGLASRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGD-----TVPLEEP 539

Query: 432 LL--------AGEDIVQVSCGGTHSVVLTSDGRIFSY 346
            +        AG+ +V ++CG T+S  +T++G ++++
Sbjct: 540 KVISAFSGKQAGKHVVHIACGSTYSAAITAEGELYTW 576



 Score = 63.2 bits (152), Expect = 9e-10
 Identities = 43/163 (26%), Positives = 70/163 (42%), Gaps = 54/163 (33%)
 Frame = -3

Query: 672  LWAWGNNEYGQ------------------------------------------------- 640
            ++ WG+N  GQ                                                 
Sbjct: 3956 IYGWGHNHRGQLGGIEGAKVKVPTPCEALATLRPVQLIGGEQTLFAVTADGKLYATGYGA 4015

Query: 639  ---LGIGDTQPRSQPIRVEGLSNLSLVDIA--AGGWHSAALTKEGEVYAWGRGEHGRLGF 475
               LGIG T+  S P  +E + ++ +  +A  +GG H  AL+ EGEVY+WG  E G+LG 
Sbjct: 4016 GGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAEDGKLGH 4075

Query: 474  GDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSY 346
            G ++S    P  ++ L G ++V V+ GG HS  +T+ G ++++
Sbjct: 4076 G-NRSPCDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTW 4117



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 29/75 (38%), Positives = 45/75 (60%), Gaps = 2/75 (2%)
 Frame = -3

Query: 747  VQGL--EQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLS 574
            V+GL  +++  +AVGA H LA++    ++AWG+N++GQ G G T    +P  V+GL    
Sbjct: 3252 VEGLRGKKIVHVAVGALHCLAVTDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQK 3311

Query: 573  LVDIAAGGWHSAALT 529
            +  +A G  HS A T
Sbjct: 3312 ITRVACGSSHSVAWT 3326



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 26/74 (35%), Positives = 40/74 (54%), Gaps = 2/74 (2%)
 Frame = -3

Query: 750  RVQGLE--QVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNL 577
            +VQGL+  +V  IA G+ H +  + D  ++ WG+N+ GQLG G T    +P  V  L   
Sbjct: 4244 QVQGLQGKKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQLGDGTTNAIQRPRLVAALQGK 4303

Query: 576  SLVDIAAGGWHSAA 535
             +  +A G  H+ A
Sbjct: 4304 KVNRVACGSAHTLA 4317

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>RCBT2_MOUSE (Q99LJ7) RCC1 and BTB domain-containing protein 2 (Regulator of|
           chromosome condensation and BTB domain-containing
           protein 2) (Chromosome condensation 1-like)
          Length = 551

 Score = 96.7 bits (239), Expect = 7e-20
 Identities = 54/155 (34%), Positives = 84/155 (54%), Gaps = 1/155 (0%)
 Frame = -3

Query: 735 EQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEG-LSNLSLVDIA 559
           +QV  +A G++H+L L+ D  ++AWG N  GQ+G G T  +  P RV G L N  +++IA
Sbjct: 152 KQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTANQPIPRRVTGCLQNKVVMNIA 211

Query: 558 AGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSV 379
            G   S A+   GEVY WG   +G+LG G    +   P +V  L G  + +V+CG  H++
Sbjct: 212 CGQMCSMAVVDTGEVYVWGYNGNGQLGLG-SSGNQPTPCRVAALQGIRVQRVACGYAHTL 270

Query: 378 VLTSDGRIFSYXXXXXXXXXXXRKVTTGHPMEVPI 274
           VLT +G+I+++            K    +P  V +
Sbjct: 271 VLTDEGQIYAWGANSYGQLGTGNKSNQSYPTPVVV 305



 Score = 77.8 bits (190), Expect = 3e-14
 Identities = 46/174 (26%), Positives = 78/174 (44%), Gaps = 1/174 (0%)
 Frame = -3

Query: 702 HNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVE-GLSNLSLVDIAAGGWHSAALTK 526
           H +  + D  ++ WG+N Y QLG G T     P  +   LSN  ++++A G +HS  LT 
Sbjct: 110 HIVLATTDGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTS 169

Query: 525 EGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSY 346
           +GEV+AWG    G++G G   +  +       L  + ++ ++CG   S+ +   G ++ +
Sbjct: 170 DGEVFAWGYNNSGQVGSGSTANQPIPRRVTGCLQNKVVMNIACGQMCSMAVVDTGEVYVW 229

Query: 345 XXXXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGRHTLAI 184
                                   N P P    + +G+ +   VACG  HTL +
Sbjct: 230 GYNGNGQLGLGSSG----------NQPTPCRVAALQGI-RVQRVACGYAHTLVL 272



 Score = 77.4 bits (189), Expect = 4e-14
 Identities = 53/191 (27%), Positives = 91/191 (47%), Gaps = 2/191 (1%)
 Frame = -3

Query: 747 VQGLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLV 568
           +Q + Q  +        L  +V+  ++  G N  G LG+GD Q   +P R++ L+   + 
Sbjct: 42  LQLIRQACVFGSAGNEVLYTTVNDEIFVLGTNCSGCLGVGDIQSTIEPRRLDSLTGKKIA 101

Query: 567 DIAAG-GWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQL-LAGEDIVQVSCG 394
            ++ G G H    T +GEV+ WG   + +LG G      +VP  +   L+ + +++V+CG
Sbjct: 102 SLSYGSGPHIVLATTDGEVFTWGHNAYSQLGNGTTNHG-LVPCHISTNLSNKQVIEVACG 160

Query: 393 GTHSVVLTSDGRIFSYXXXXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSSEGLWQANYV 214
             HS+VLTSDG +F++            +V +G     PI    P+  T          +
Sbjct: 161 SYHSLVLTSDGEVFAW------GYNNSGQVGSGSTANQPI----PRRVTGCLQNKVVMNI 210

Query: 213 ACGGRHTLAIV 181
           ACG   ++A+V
Sbjct: 211 ACGQMCSMAVV 221



 Score = 72.8 bits (177), Expect = 1e-12
 Identities = 46/139 (33%), Positives = 69/139 (49%), Gaps = 4/139 (2%)
 Frame = -3

Query: 750 RVQGLEQ---VSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSN 580
           RV G  Q   V  IA G   ++A+     ++ WG N  GQLG+G +  +  P RV  L  
Sbjct: 197 RVTGCLQNKVVMNIACGQMCSMAVVDTGEVYVWGYNGNGQLGLGSSGNQPTPCRVAALQG 256

Query: 579 LSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVS 400
           + +  +A G  H+  LT EG++YAWG   +G+LG G +KS+   P  V +     I   +
Sbjct: 257 IRVQRVACGYAHTLVLTDEGQIYAWGANSYGQLGTG-NKSNQSYPTPVVVEKDRIIEIAA 315

Query: 399 CGGTH-SVVLTSDGRIFSY 346
           C   H S   T  G ++ +
Sbjct: 316 CHSAHTSAAKTQGGHVYMW 334



 Score = 54.3 bits (129), Expect = 4e-07
 Identities = 33/85 (38%), Positives = 49/85 (57%), Gaps = 2/85 (2%)
 Frame = -3

Query: 747 VQGLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLV 568
           +QG+ +V  +A G  H L L+ +  ++AWG N YGQLG G+   +S P  V  +    ++
Sbjct: 254 LQGI-RVQRVACGYAHTLVLTDEGQIYAWGANSYGQLGTGNKSNQSYPTPVV-VEKDRII 311

Query: 567 DIAA--GGWHSAALTKEGEVYAWGR 499
           +IAA      SAA T+ G VY WG+
Sbjct: 312 EIAACHSAHTSAAKTQGGHVYMWGQ 336

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>RCBT2_RAT (Q6P798) RCC1 and BTB domain-containing protein 2 (Regulator of|
           chromosome condensation and BTB domain-containing
           protein 2) (Chromosome condensation 1-like)
          Length = 551

 Score = 96.3 bits (238), Expect = 9e-20
 Identities = 54/155 (34%), Positives = 83/155 (53%), Gaps = 1/155 (0%)
 Frame = -3

Query: 735 EQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEG-LSNLSLVDIA 559
           +QV  +A G++H+L L+ D  ++AWG N  GQ+G G T  +  P RV G L N  ++ IA
Sbjct: 152 KQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTANQPIPRRVTGCLQNKVVMSIA 211

Query: 558 AGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSV 379
            G   S A+   GEVY WG   +G+LG G    +   P +V  L G  + +V+CG  H++
Sbjct: 212 CGQMCSMAVVDTGEVYVWGYNGNGQLGLG-SSGNQPTPCRVAALQGIRVQRVACGYAHTL 270

Query: 378 VLTSDGRIFSYXXXXXXXXXXXRKVTTGHPMEVPI 274
           VLT +G+I+++            K    +P  V +
Sbjct: 271 VLTDEGQIYAWGANSYGQLGTGNKSNQSYPTPVVV 305



 Score = 78.2 bits (191), Expect = 3e-14
 Identities = 53/191 (27%), Positives = 91/191 (47%), Gaps = 2/191 (1%)
 Frame = -3

Query: 747 VQGLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLV 568
           +Q + Q  +        L  +V+  ++  G N  G LG+GD Q   +P R++ L+   + 
Sbjct: 42  LQLIRQACVFGTAGNEVLYTTVNDEIFVLGTNCSGCLGVGDIQSTIEPRRLDSLTGKKIA 101

Query: 567 DIAAG-GWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQL-LAGEDIVQVSCG 394
            ++ G G H    T +GEV+ WG   + +LG G      +VP  +   L+ + +++V+CG
Sbjct: 102 SLSYGSGPHIVLATTDGEVFTWGHNAYSQLGNGTTNHG-LVPCHISTNLSNKQVIEVACG 160

Query: 393 GTHSVVLTSDGRIFSYXXXXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSSEGLWQANYV 214
             HS+VLTSDG +F++            +V +G     PI    P+  T          +
Sbjct: 161 SYHSLVLTSDGEVFAW------GYNNSGQVGSGSTANQPI----PRRVTGCLQNKVVMSI 210

Query: 213 ACGGRHTLAIV 181
           ACG   ++A+V
Sbjct: 211 ACGQMCSMAVV 221



 Score = 77.8 bits (190), Expect = 3e-14
 Identities = 46/174 (26%), Positives = 78/174 (44%), Gaps = 1/174 (0%)
 Frame = -3

Query: 702 HNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVE-GLSNLSLVDIAAGGWHSAALTK 526
           H +  + D  ++ WG+N Y QLG G T     P  +   LSN  ++++A G +HS  LT 
Sbjct: 110 HIVLATTDGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTS 169

Query: 525 EGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSY 346
           +GEV+AWG    G++G G   +  +       L  + ++ ++CG   S+ +   G ++ +
Sbjct: 170 DGEVFAWGYNNSGQVGSGSTANQPIPRRVTGCLQNKVVMSIACGQMCSMAVVDTGEVYVW 229

Query: 345 XXXXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGRHTLAI 184
                                   N P P    + +G+ +   VACG  HTL +
Sbjct: 230 GYNGNGQLGLGSSG----------NQPTPCRVAALQGI-RVQRVACGYAHTLVL 272



 Score = 73.2 bits (178), Expect = 8e-13
 Identities = 45/133 (33%), Positives = 66/133 (49%), Gaps = 3/133 (2%)
 Frame = -3

Query: 750 RVQGLEQ---VSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSN 580
           RV G  Q   V  IA G   ++A+     ++ WG N  GQLG+G +  +  P RV  L  
Sbjct: 197 RVTGCLQNKVVMSIACGQMCSMAVVDTGEVYVWGYNGNGQLGLGSSGNQPTPCRVAALQG 256

Query: 579 LSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVS 400
           + +  +A G  H+  LT EG++YAWG   +G+LG G +KS+   P  V +     I   +
Sbjct: 257 IRVQRVACGYAHTLVLTDEGQIYAWGANSYGQLGTG-NKSNQSYPTPVVVEKDRIIEIAA 315

Query: 399 CGGTHSVVLTSDG 361
           C   H+    S G
Sbjct: 316 CHSAHTSAAKSQG 328



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 32/85 (37%), Positives = 49/85 (57%), Gaps = 2/85 (2%)
 Frame = -3

Query: 747 VQGLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLV 568
           +QG+ +V  +A G  H L L+ +  ++AWG N YGQLG G+   +S P  V  +    ++
Sbjct: 254 LQGI-RVQRVACGYAHTLVLTDEGQIYAWGANSYGQLGTGNKSNQSYPTPVV-VEKDRII 311

Query: 567 DIAA--GGWHSAALTKEGEVYAWGR 499
           +IAA      SAA ++ G VY WG+
Sbjct: 312 EIAACHSAHTSAAKSQGGHVYMWGQ 336

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>RCBT2_PONPY (Q5RCZ7) RCC1 and BTB domain-containing protein 2 (Regulator of|
           chromosome condensation and BTB domain-containing
           protein 2)
          Length = 551

 Score = 95.1 bits (235), Expect = 2e-19
 Identities = 53/155 (34%), Positives = 83/155 (53%), Gaps = 1/155 (0%)
 Frame = -3

Query: 735 EQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEG-LSNLSLVDIA 559
           +QV  +A G++H+L L+ D  ++AWG N  GQ+G G T  +  P RV G L N  +V IA
Sbjct: 152 KQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIA 211

Query: 558 AGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSV 379
            G     A+   GEVY WG   +G+LG G +  +   P +V  L G  + +V+CG  H++
Sbjct: 212 CGQMCCMAVVDTGEVYVWGYNGNGQLGLG-NSGNQPTPCRVAALQGIRVQRVACGYAHTL 270

Query: 378 VLTSDGRIFSYXXXXXXXXXXXRKVTTGHPMEVPI 274
           VLT +G+++++            K    +P  V +
Sbjct: 271 VLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPVTV 305



 Score = 77.4 bits (189), Expect = 4e-14
 Identities = 54/191 (28%), Positives = 91/191 (47%), Gaps = 2/191 (1%)
 Frame = -3

Query: 747 VQGLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLV 568
           +Q + Q  +        L  +V+  ++  G N  G LG+GD Q   +P R++ L+   + 
Sbjct: 42  LQLIRQACVFGSAGNEVLYTTVNDEIFVLGTNCCGCLGLGDVQSTIEPRRLDSLNGKKIA 101

Query: 567 DIAAG-GWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQL-LAGEDIVQVSCG 394
            ++ G G H    T EGEV+ WG   + +LG G      +VP  +   L+ + +++V+CG
Sbjct: 102 CLSYGSGPHIVLATTEGEVFTWGHNAYSQLGNGTTNHG-LVPCHISTNLSNKQVIEVACG 160

Query: 393 GTHSVVLTSDGRIFSYXXXXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSSEGLWQANYV 214
             HS+VLTSDG +F++            +V +G      +N P P+  T          +
Sbjct: 161 SYHSLVLTSDGEVFAW------GYNNSGQVGSGS----TVNQPIPRRVTGCLQNKVVVTI 210

Query: 213 ACGGRHTLAIV 181
           ACG    +A+V
Sbjct: 211 ACGQMCCMAVV 221



 Score = 74.3 bits (181), Expect = 4e-13
 Identities = 48/139 (34%), Positives = 70/139 (50%), Gaps = 4/139 (2%)
 Frame = -3

Query: 750 RVQGLEQ---VSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSN 580
           RV G  Q   V  IA G    +A+     ++ WG N  GQLG+G++  +  P RV  L  
Sbjct: 197 RVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQPTPCRVAALQG 256

Query: 579 LSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVS 400
           + +  +A G  H+  LT EG+VYAWG   +G+LG G +KS+   P  V +     I   +
Sbjct: 257 IRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTG-NKSNQSYPTPVTVEKDRIIEIAA 315

Query: 399 CGGTH-SVVLTSDGRIFSY 346
           C  TH S   T  G ++ +
Sbjct: 316 CHSTHTSAAKTQGGHVYMW 334



 Score = 74.3 bits (181), Expect = 4e-13
 Identities = 45/174 (25%), Positives = 77/174 (44%), Gaps = 1/174 (0%)
 Frame = -3

Query: 702 HNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVE-GLSNLSLVDIAAGGWHSAALTK 526
           H +  + +  ++ WG+N Y QLG G T     P  +   LSN  ++++A G +HS  LT 
Sbjct: 110 HIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTS 169

Query: 525 EGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSY 346
           +GEV+AWG    G++G G   +  +       L  + +V ++CG    + +   G ++ +
Sbjct: 170 DGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVW 229

Query: 345 XXXXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGRHTLAI 184
                                   N P P    + +G+ +   VACG  HTL +
Sbjct: 230 GYNGNGQLGLGNSG----------NQPTPCRVAALQGI-RVQRVACGYAHTLVL 272



 Score = 53.5 bits (127), Expect = 7e-07
 Identities = 33/85 (38%), Positives = 49/85 (57%), Gaps = 2/85 (2%)
 Frame = -3

Query: 747 VQGLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLV 568
           +QG+ +V  +A G  H L L+ +  ++AWG N YGQLG G+   +S P  V  +    ++
Sbjct: 254 LQGI-RVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPVT-VEKDRII 311

Query: 567 DIAA--GGWHSAALTKEGEVYAWGR 499
           +IAA      SAA T+ G VY WG+
Sbjct: 312 EIAACHSTHTSAAKTQGGHVYMWGQ 336

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>RCBT2_HUMAN (O95199) RCC1 and BTB domain-containing protein 2 (Regulator of|
           chromosome condensation and BTB domain-containing
           protein 2) (Chromosome condensation 1-like) (CHC1-L)
           (RCC1-like G exchanging factor)
          Length = 551

 Score = 95.1 bits (235), Expect = 2e-19
 Identities = 53/155 (34%), Positives = 83/155 (53%), Gaps = 1/155 (0%)
 Frame = -3

Query: 735 EQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEG-LSNLSLVDIA 559
           +QV  +A G++H+L L+ D  ++AWG N  GQ+G G T  +  P RV G L N  +V IA
Sbjct: 152 KQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIA 211

Query: 558 AGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSV 379
            G     A+   GEVY WG   +G+LG G +  +   P +V  L G  + +V+CG  H++
Sbjct: 212 CGQMCCMAVVDTGEVYVWGYNGNGQLGLG-NSGNQPTPCRVAALQGIRVQRVACGYAHTL 270

Query: 378 VLTSDGRIFSYXXXXXXXXXXXRKVTTGHPMEVPI 274
           VLT +G+++++            K    +P  V +
Sbjct: 271 VLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPVTV 305



 Score = 77.4 bits (189), Expect = 4e-14
 Identities = 54/191 (28%), Positives = 91/191 (47%), Gaps = 2/191 (1%)
 Frame = -3

Query: 747 VQGLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLV 568
           +Q + Q  +        L  +V+  ++  G N  G LG+GD Q   +P R++ L+   + 
Sbjct: 42  LQLIRQACVFGSAGNEVLYTTVNDEIFVLGTNCCGCLGLGDVQSTIEPRRLDSLNGKKIA 101

Query: 567 DIAAG-GWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQL-LAGEDIVQVSCG 394
            ++ G G H    T EGEV+ WG   + +LG G      +VP  +   L+ + +++V+CG
Sbjct: 102 CLSYGSGPHIVLATTEGEVFTWGHNAYSQLGNGTTNHG-LVPCHISTNLSNKQVIEVACG 160

Query: 393 GTHSVVLTSDGRIFSYXXXXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSSEGLWQANYV 214
             HS+VLTSDG +F++            +V +G      +N P P+  T          +
Sbjct: 161 SYHSLVLTSDGEVFAW------GYNNSGQVGSGS----TVNQPIPRRVTGCLQNKVVVTI 210

Query: 213 ACGGRHTLAIV 181
           ACG    +A+V
Sbjct: 211 ACGQMCCMAVV 221



 Score = 74.3 bits (181), Expect = 4e-13
 Identities = 48/139 (34%), Positives = 70/139 (50%), Gaps = 4/139 (2%)
 Frame = -3

Query: 750 RVQGLEQ---VSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSN 580
           RV G  Q   V  IA G    +A+     ++ WG N  GQLG+G++  +  P RV  L  
Sbjct: 197 RVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQPTPCRVAALQG 256

Query: 579 LSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVS 400
           + +  +A G  H+  LT EG+VYAWG   +G+LG G +KS+   P  V +     I   +
Sbjct: 257 IRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTG-NKSNQSYPTPVTVEKDRIIEIAA 315

Query: 399 CGGTH-SVVLTSDGRIFSY 346
           C  TH S   T  G ++ +
Sbjct: 316 CHSTHTSAAKTQGGHVYMW 334



 Score = 74.3 bits (181), Expect = 4e-13
 Identities = 45/174 (25%), Positives = 77/174 (44%), Gaps = 1/174 (0%)
 Frame = -3

Query: 702 HNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVE-GLSNLSLVDIAAGGWHSAALTK 526
           H +  + +  ++ WG+N Y QLG G T     P  +   LSN  ++++A G +HS  LT 
Sbjct: 110 HIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTS 169

Query: 525 EGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSY 346
           +GEV+AWG    G++G G   +  +       L  + +V ++CG    + +   G ++ +
Sbjct: 170 DGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVW 229

Query: 345 XXXXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGRHTLAI 184
                                   N P P    + +G+ +   VACG  HTL +
Sbjct: 230 GYNGNGQLGLGNSG----------NQPTPCRVAALQGI-RVQRVACGYAHTLVL 272



 Score = 53.5 bits (127), Expect = 7e-07
 Identities = 33/85 (38%), Positives = 49/85 (57%), Gaps = 2/85 (2%)
 Frame = -3

Query: 747 VQGLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLV 568
           +QG+ +V  +A G  H L L+ +  ++AWG N YGQLG G+   +S P  V  +    ++
Sbjct: 254 LQGI-RVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPVT-VEKDRII 311

Query: 567 DIAA--GGWHSAALTKEGEVYAWGR 499
           +IAA      SAA T+ G VY WG+
Sbjct: 312 EIAACHSTHTSAAKTQGGHVYMWGQ 336

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>RCC2_HUMAN (Q9P258) Protein RCC2 (Telophase disk protein of 60 kDa) (RCC1-like|
           protein TD-60)
          Length = 522

 Score = 92.8 bits (229), Expect = 1e-18
 Identities = 45/121 (37%), Positives = 74/121 (61%)
 Frame = -3

Query: 708 AFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALT 529
           A H+L ++ +  LW+WG NE GQLG GDT+    P  +EGLS+  +V  A G  H+ ALT
Sbjct: 159 AAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVIVSAACGRNHTLALT 218

Query: 528 KEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFS 349
           + G V+A+G  + G+LG G+   +   P Q+ +  G+ I +++CG   S+++   G ++S
Sbjct: 219 ETGSVFAFGENKMGQLGLGNQTDAVPSPAQI-MYNGQPITKMACGAEFSMIMDCKGNLYS 277

Query: 348 Y 346
           +
Sbjct: 278 F 278



 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 48/162 (29%), Positives = 76/162 (46%), Gaps = 28/162 (17%)
 Frame = -3

Query: 747 VQGL--EQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIG---DTQPRSQPIRVEGLS 583
           ++GL  E +   A G  H LAL+    ++A+G N+ GQLG+G   D  P    I   G  
Sbjct: 196 IEGLSHEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNG-- 253

Query: 582 NLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDD-----------KSSHMVPLQV 436
              +  +A G   S  +  +G +Y++G  E+G+LG   D               +VP +V
Sbjct: 254 -QPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRV 312

Query: 435 ----------QLLAGEDIV--QVSCGGTHSVVLTSDGRIFSY 346
                     Q+L   ++V   V+CG  H++VL S  R+FS+
Sbjct: 313 AIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSW 354



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 42/154 (27%), Positives = 69/154 (44%), Gaps = 26/154 (16%)
 Frame = -3

Query: 735 EQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIG----------------DTQPRSQP 604
           + ++ +A GA  ++ +     L+++G  EYGQLG                  +  PR   
Sbjct: 254 QPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVA 313

Query: 603 IRVEG--------LSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMV 448
           I +E         + N+ + D+A G  H+  L  +  V++WG G +GRLG  + K   MV
Sbjct: 314 IFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQK-DEMV 372

Query: 447 PLQVQL--LAGEDIVQVSCGGTHSVVLTSDGRIF 352
           P  V+L    G    Q+  G T S  ++  G +F
Sbjct: 373 PRLVKLFDFPGRGASQIYAGYTCSFAVSEVGGLF 406

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>RCC2_BRARE (Q6NYE2) Protein RCC2 homolog|
          Length = 495

 Score = 92.8 bits (229), Expect = 1e-18
 Identities = 49/131 (37%), Positives = 77/131 (58%), Gaps = 2/131 (1%)
 Frame = -3

Query: 732 QVSMIAVG--AFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIA 559
           QVS +  G  A H+L ++ +  LW+WG N+ GQLG GDT+    P  +EGL    +V  A
Sbjct: 122 QVSCVVSGPCAAHSLIITTEGKLWSWGRNDKGQLGHGDTKRLEAPKLIEGLGEEVIVAAA 181

Query: 558 AGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSV 379
            G  H+ ALT+ G VY +G  + G+LG G+   + + P  +Q   G+ IV+V+CG   S+
Sbjct: 182 CGRNHTLALTENGTVYTFGENKLGQLGQGNQTDAVLSPATIQ-YNGQPIVKVACGAEFSM 240

Query: 378 VLTSDGRIFSY 346
           ++   G ++S+
Sbjct: 241 IVDCKGNLYSF 251



 Score = 57.8 bits (138), Expect = 4e-08
 Identities = 44/156 (28%), Positives = 75/156 (48%), Gaps = 24/156 (15%)
 Frame = -3

Query: 741 GLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGD-TQPRSQPIRVEGLSNLSLVD 565
           G E +   A G  H LAL+ +  ++ +G N+ GQLG G+ T     P  ++  +   +V 
Sbjct: 173 GEEVIVAAACGRNHTLALTENGTVYTFGENKLGQLGQGNQTDAVLSPATIQ-YNGQPIVK 231

Query: 564 IAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDK-----------SSHMVPLQV------ 436
           +A G   S  +  +G +Y++G  E+G+LG   D               ++P +V      
Sbjct: 232 VACGAEFSMIVDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEFDCELIPRRVAIFIEK 291

Query: 435 ----QLLAGEDIV--QVSCGGTHSVVLTSDGRIFSY 346
               Q+L   ++V   V+CG  H++VL S  R+FS+
Sbjct: 292 TKDGQVLPVPNVVARDVACGANHTLVLDSQKRVFSW 327



 Score = 53.9 bits (128), Expect = 5e-07
 Identities = 45/154 (29%), Positives = 68/154 (44%), Gaps = 26/154 (16%)
 Frame = -3

Query: 735 EQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLG-------IGDTQ---------PRSQP 604
           + +  +A GA  ++ +     L+++G  EYGQLG       I   Q         PR   
Sbjct: 227 QPIVKVACGAEFSMIVDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEFDCELIPRRVA 286

Query: 603 IRVEG--------LSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMV 448
           I +E         + N+   D+A G  H+  L  +  V++WG G +GRLG  + K   MV
Sbjct: 287 IFIEKTKDGQVLPVPNVVARDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQK-DEMV 345

Query: 447 PLQVQL--LAGEDIVQVSCGGTHSVVLTSDGRIF 352
           P  V+L    G    Q+ CG   S  L+  G +F
Sbjct: 346 PRLVKLFDFPGRGATQIYCGYQCSFALSEMGGLF 379

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>RCBT1_MOUSE (Q6NXM2) RCC1 and BTB domain-containing protein 1 (Regulator of|
           chromosome condensation and BTB domain-containing
           protein 1)
          Length = 531

 Score = 92.0 bits (227), Expect = 2e-18
 Identities = 48/132 (36%), Positives = 79/132 (59%), Gaps = 1/132 (0%)
 Frame = -3

Query: 738 LEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEG-LSNLSLVDI 562
           ++QV  +A G+ H++AL+ D  L+AWG N  GQ+G G T  +  P +V   L    +V+I
Sbjct: 127 IKQVIEVACGSHHSMALAADGELFAWGYNNCGQVGSGSTANQPTPRKVTNCLHTKRVVNI 186

Query: 561 AAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHS 382
           A G   S A+   GEVY WG   +G+LG G++  + + P++V  L G  + Q+ CG  H+
Sbjct: 187 ACGQTSSMAVLDSGEVYGWGYNGNGQLGLGNN-GNQLTPVRVAALHGMCVNQIVCGYAHT 245

Query: 381 VVLTSDGRIFSY 346
           + LT +G ++++
Sbjct: 246 LALTDEGLLYAW 257



 Score = 76.6 bits (187), Expect = 7e-14
 Identities = 47/174 (27%), Positives = 78/174 (44%), Gaps = 1/174 (0%)
 Frame = -3

Query: 702 HNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRV-EGLSNLSLVDIAAGGWHSAALTK 526
           H L  + D +++AWG+N Y QLG G T     P++V   L    ++++A G  HS AL  
Sbjct: 86  HVLLTTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVIEVACGSHHSMALAA 145

Query: 525 EGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSY 346
           +GE++AWG    G++G G   +          L  + +V ++CG T S+ +   G ++ +
Sbjct: 146 DGELFAWGYNNCGQVGSGSTANQPTPRKVTNCLHTKRVVNIACGQTSSMAVLDSGEVYGW 205

Query: 345 XXXXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGRHTLAI 184
                             P+ V           +  G+   N + CG  HTLA+
Sbjct: 206 GYNGNGQLGLGNNGNQLTPVRV----------AALHGMC-VNQIVCGYAHTLAL 248



 Score = 73.9 bits (180), Expect = 5e-13
 Identities = 43/131 (32%), Positives = 69/131 (52%), Gaps = 1/131 (0%)
 Frame = -3

Query: 735 EQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAA 556
           ++V  IA G   ++A+     ++ WG N  GQLG+G+   +  P+RV  L  + +  I  
Sbjct: 181 KRVVNIACGQTSSMAVLDSGEVYGWGYNGNGQLGLGNNGNQLTPVRVAALHGMCVNQIVC 240

Query: 555 GGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTH-SV 379
           G  H+ ALT EG +YAWG   +G+LG G  K++ + P Q+ +     I   +C  TH S 
Sbjct: 241 GYAHTLALTDEGLLYAWGANTYGQLGTG-SKNNLLSPTQIMVEKERVIEIAACHSTHTSA 299

Query: 378 VLTSDGRIFSY 346
             T  G ++ +
Sbjct: 300 AKTQGGHVYMW 310



 Score = 64.7 bits (156), Expect = 3e-10
 Identities = 46/166 (27%), Positives = 80/166 (48%), Gaps = 2/166 (1%)
 Frame = -3

Query: 672 LWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAG-GWHSAALTKEGEVYAWGRG 496
           ++ +G N    LG GD Q    P ++E L    +  ++ G G H    T++G VYAWG  
Sbjct: 43  VFVFGLNYSNCLGTGDNQSTLVPKKLEALCGKKIKSLSYGSGPHVLLTTEDGVVYAWGHN 102

Query: 495 EHGRLGFGDDKSSHMVPLQV-QLLAGEDIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXX 319
            + +LG G      + P+QV   L  + +++V+CG  HS+ L +DG +F++         
Sbjct: 103 GYSQLGNGTTNQG-IAPVQVCTNLLIKQVIEVACGSHHSMALAADGELFAW------GYN 155

Query: 318 XXRKVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGRHTLAIV 181
              +V +G       N P P+  T+     +   +ACG   ++A++
Sbjct: 156 NCGQVGSGS----TANQPTPRKVTNCLHTKRVVNIACGQTSSMAVL 197



 Score = 53.1 bits (126), Expect = 9e-07
 Identities = 31/79 (39%), Positives = 44/79 (55%), Gaps = 2/79 (2%)
 Frame = -3

Query: 729 VSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAA-- 556
           V+ I  G  H LAL+ + +L+AWG N YGQLG G       P ++  +    +++IAA  
Sbjct: 235 VNQIVCGYAHTLALTDEGLLYAWGANTYGQLGTGSKNNLLSPTQIM-VEKERVIEIAACH 293

Query: 555 GGWHSAALTKEGEVYAWGR 499
               SAA T+ G VY WG+
Sbjct: 294 STHTSAAKTQGGHVYMWGQ 312



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 32/118 (27%), Positives = 56/118 (47%), Gaps = 1/118 (0%)
 Frame = -3

Query: 534 LTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCG-GTHSVVLTSDGR 358
           +T   EV+ +G      LG GD++S+ +VP +++ L G+ I  +S G G H ++ T DG 
Sbjct: 37  VTDNDEVFVFGLNYSNCLGTGDNQST-LVPKKLEALCGKKIKSLSYGSGPHVLLTTEDGV 95

Query: 357 IFSYXXXXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGRHTLAI 184
           ++++                  P++V  NL           + Q   VACG  H++A+
Sbjct: 96  VYAWGHNGYSQLGNGTTNQGIAPVQVCTNLL----------IKQVIEVACGSHHSMAL 143

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>RCC2_XENLA (Q52KW8) Protein RCC2 homolog|
          Length = 513

 Score = 90.5 bits (223), Expect = 5e-18
 Identities = 49/131 (37%), Positives = 75/131 (57%), Gaps = 2/131 (1%)
 Frame = -3

Query: 732 QVSMIAVG--AFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIA 559
           QV  +A G  A H+L ++V+  LW+WG N+ GQLG GD +    P  +E L     V  A
Sbjct: 140 QVRSVASGSCAAHSLLITVEGKLWSWGRNDKGQLGHGDIKRIDVPKLIESLKGEVFVHAA 199

Query: 558 AGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSV 379
            G  H+ ALT+ G VYA+G  + G+LG G+   +   P Q+ L  G+ I +V+CG   S+
Sbjct: 200 CGRNHTLALTENGSVYAFGENKMGQLGLGNKTDAVPSPAQI-LYNGQPITKVACGAEFSM 258

Query: 378 VLTSDGRIFSY 346
           ++   G ++S+
Sbjct: 259 IMDCKGNLYSF 269



 Score = 53.9 bits (128), Expect = 5e-07
 Identities = 40/150 (26%), Positives = 67/150 (44%), Gaps = 26/150 (17%)
 Frame = -3

Query: 717 AVGAFHNLALSVDRILWAWGNNEYGQLGIG---DTQPRSQPIRVEGLSNLSLVDIAAGGW 547
           A G  H LAL+ +  ++A+G N+ GQLG+G   D  P    I   G     +  +A G  
Sbjct: 199 ACGRNHTLALTENGSVYAFGENKMGQLGLGNKTDAVPSPAQILYNGQP---ITKVACGAE 255

Query: 546 HSAALTKEGEVYAWGRGEHGRLGFGDDKS----SHMVPLQVQLLAGEDIV---------- 409
            S  +  +G +Y++G  E+G+LG   D      +  +    +L+A    +          
Sbjct: 256 FSMIMDCKGNLYSFGCPEYGQLGHNSDGKYIARAQRIEYDCELIARRIAIFIEKTKDGQI 315

Query: 408 ---------QVSCGGTHSVVLTSDGRIFSY 346
                     ++CG  HS++L S  R+FS+
Sbjct: 316 LPVPNVVVRDIACGINHSLILDSQKRVFSW 345



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 43/154 (27%), Positives = 69/154 (44%), Gaps = 26/154 (16%)
 Frame = -3

Query: 735 EQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGI---GDTQPRSQPIRVE--------- 592
           + ++ +A GA  ++ +     L+++G  EYGQLG    G    R+Q I  +         
Sbjct: 245 QPITKVACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKYIARAQRIEYDCELIARRIA 304

Query: 591 ------------GLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMV 448
                        + N+ + DIA G  HS  L  +  V++WG G +GRLG  + +   MV
Sbjct: 305 IFIEKTKDGQILPVPNVVVRDIACGINHSLILDSQKRVFSWGFGGYGRLGHSEQR-DEMV 363

Query: 447 PLQVQL--LAGEDIVQVSCGGTHSVVLTSDGRIF 352
           P  V+L    G    Q+  G T S  ++  G +F
Sbjct: 364 PRLVKLFDFPGRGAAQIYAGATCSFAVSEMGGLF 397

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>NEK8_MOUSE (Q91ZR4) Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never|
           in mitosis A-related kinase 8) (NimA-related protein
           kinase 8)
          Length = 698

 Score = 89.4 bits (220), Expect = 1e-17
 Identities = 48/127 (37%), Positives = 71/127 (55%)
 Frame = -3

Query: 729 VSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGG 550
           +  +A G      L+   I+  +G+   G LG G+    SQP  VE L    +V +A G 
Sbjct: 399 IKHVACGDLFTACLTDRGIIMTFGSGSNGCLGHGNLTDISQPTIVEALLGYEMVQVACGA 458

Query: 549 WHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLT 370
            H  AL+ +GE++AWGRG+ GRLG G  + SH  P QV +  G++  +V CG   S++LT
Sbjct: 459 SHVLALSTDGELFAWGRGDGGRLGLG-TRESHNCPQQVPVAPGQEAQRVVCGIDSSMILT 517

Query: 369 SDGRIFS 349
           S GR+ +
Sbjct: 518 SPGRVLA 524



 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 37/113 (32%), Positives = 62/113 (54%)
 Frame = -3

Query: 735 EQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAA 556
           E +  + +G  H+ A++     + +G+N++GQLG    +    P RV+GL  + +V +A 
Sbjct: 567 EPLLCVDLGTAHSAAITASGDCYTFGSNQHGQLGTSSRRVSRAPCRVQGLEGIKMVMVAC 626

Query: 555 GGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSC 397
           G   + A+  EGEVY+WG+G  GRLG  D+ +    P+Q+       +  VSC
Sbjct: 627 GDAFTVAVGAEGEVYSWGKGTRGRLGRRDEDAGLPRPVQLDETHPYMVTSVSC 679



 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 34/116 (29%), Positives = 61/116 (52%)
 Frame = -3

Query: 621 QPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPL 442
           QP+     +EG S +++  +A G   +A LT  G +  +G G +G LG G+  +    P 
Sbjct: 383 QPQFVSRFLEGQSGVTIKHVACGDLFTACLTDRGIIMTFGSGSNGCLGHGN-LTDISQPT 441

Query: 441 QVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXRKVTTGHPMEVPI 274
            V+ L G ++VQV+CG +H + L++DG +F++            + +   P +VP+
Sbjct: 442 IVEALLGYEMVQVACGASHVLALSTDGELFAWGRGDGGRLGLGTRESHNCPQQVPV 497



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 52/199 (26%), Positives = 78/199 (39%), Gaps = 13/199 (6%)
 Frame = -3

Query: 741  GLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDI 562
            G E V  +A GA H LALS D  L+AWG  + G+LG+G  +  + P +V          +
Sbjct: 448  GYEMVQ-VACGASHVLALSTDGELFAWGRGDGGRLGLGTRESHNCPQQVPVAPGQEAQRV 506

Query: 561  AAGGWHSAALTKEGEVYAWGRGEHGRLGFGD-------------DKSSHMVPLQVQLLAG 421
              G   S  LT  G V A G     +LG                +++    PL    L  
Sbjct: 507  VCGIDSSMILTSPGRVLACGSNRFNKLGLDHLSLDEEPVPYQQVEEALSFTPLGSAPLDQ 566

Query: 420  EDIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSS 241
            E ++ V  G  HS  +T+ G  +++            +  +  P  V             
Sbjct: 567  EPLLCVDLGTAHSAAITASGDCYTFGSNQHGQLGTSSRRVSRAPCRV----------QGL 616

Query: 240  EGLWQANYVACGGRHTLAI 184
            EG+ +   VACG   T+A+
Sbjct: 617  EGI-KMVMVACGDAFTVAV 634



 Score = 37.7 bits (86), Expect = 0.038
 Identities = 44/159 (27%), Positives = 63/159 (39%), Gaps = 14/159 (8%)
 Frame = -3

Query: 612 SQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQ 433
           S P+R+  L N  +V +AAG    A +T+ G +  W   E   LG G      ++P  V+
Sbjct: 328 SSPLRLPML-NTEVVQVAAGRTQKAGVTRSGRLILW---EAPPLGAG---GGTLLPGAVE 380

Query: 432 L------------LAGEDIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXRKVTTGHP 289
           L             +G  I  V+CG   +  LT  G I ++                GH 
Sbjct: 381 LPQPQFVSRFLEGQSGVTIKHVACGDLFTACLTDRGIIMTFGSGSNG--------CLGHG 432

Query: 288 MEVPINLPPPKTSTSSEGL--WQANYVACGGRHTLAIVT 178
               I+ P     T  E L  ++   VACG  H LA+ T
Sbjct: 433 NLTDISQP-----TIVEALLGYEMVQVACGASHVLALST 466



 Score = 30.8 bits (68), Expect = 4.7
 Identities = 16/44 (36%), Positives = 25/44 (56%), Gaps = 2/44 (4%)
 Frame = -3

Query: 750 RVQGLEQVS--MIAVGAFHNLALSVDRILWAWGNNEYGQLGIGD 625
           RVQGLE +   M+A G    +A+  +  +++WG    G+LG  D
Sbjct: 612 RVQGLEGIKMVMVACGDAFTVAVGAEGEVYSWGKGTRGRLGRRD 655

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>RCC2_MOUSE (Q8BK67) Protein RCC2|
          Length = 520

 Score = 88.6 bits (218), Expect = 2e-17
 Identities = 44/121 (36%), Positives = 73/121 (60%)
 Frame = -3

Query: 708 AFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALT 529
           A H+L ++ +  LW+WG NE GQLG GDT+    P  +E LS+ ++V  A G  H+ ALT
Sbjct: 157 AAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEALSHEAIVLAACGRNHTLALT 216

Query: 528 KEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFS 349
             G V+A+G  + G+LG G+   +   P Q+ +  G+ I +++CG   S+++   G ++S
Sbjct: 217 DTGSVFAFGENKMGQLGLGNQTDAVPSPAQI-MYNGQPITKMACGAEFSMLMDCKGNLYS 275

Query: 348 Y 346
           +
Sbjct: 276 F 276



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 46/156 (29%), Positives = 73/156 (46%), Gaps = 26/156 (16%)
 Frame = -3

Query: 735 EQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIG---DTQPRSQPIRVEGLSNLSLVD 565
           E + + A G  H LAL+    ++A+G N+ GQLG+G   D  P    I   G     +  
Sbjct: 200 EAIVLAACGRNHTLALTDTGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNG---QPITK 256

Query: 564 IAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDD-----------KSSHMVPLQV------ 436
           +A G   S  +  +G +Y++G  E+G+LG   D               +VP +V      
Sbjct: 257 MACGAEFSMLMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEK 316

Query: 435 ----QLLAGEDIV--QVSCGGTHSVVLTSDGRIFSY 346
               Q+L   ++V   V+CG  H++VL S  R+FS+
Sbjct: 317 TKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSW 352



 Score = 53.1 bits (126), Expect = 9e-07
 Identities = 42/154 (27%), Positives = 69/154 (44%), Gaps = 26/154 (16%)
 Frame = -3

Query: 735 EQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIG----------------DTQPRSQP 604
           + ++ +A GA  ++ +     L+++G  EYGQLG                  +  PR   
Sbjct: 252 QPITKMACGAEFSMLMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVA 311

Query: 603 IRVEG--------LSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMV 448
           I +E         + N+ + D+A G  H+  L  +  V++WG G +GRLG  + K   MV
Sbjct: 312 IFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQK-DEMV 370

Query: 447 PLQVQL--LAGEDIVQVSCGGTHSVVLTSDGRIF 352
           P  V+L    G    Q+  G T S  ++  G +F
Sbjct: 371 PRLVKLFDFPGRGATQIYAGYTCSFAVSEVGGLF 404

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>RCBT1_HUMAN (Q8NDN9) RCC1 and BTB domain-containing protein 1 (Regulator of|
           chromosome condensation and BTB domain-containing
           protein 1) (Chronic lymphocytic leukemia deletion region
           gene 7 protein) (CLL deletion region gene 7 protein)
          Length = 531

 Score = 87.8 bits (216), Expect = 3e-17
 Identities = 45/132 (34%), Positives = 78/132 (59%), Gaps = 1/132 (0%)
 Frame = -3

Query: 738 LEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLS-LVDI 562
           ++QV  +A G+ H++AL+ D  ++AWG N  GQ+G G T  +  P +V    ++  +V I
Sbjct: 127 IKQVVEVACGSHHSMALAADGEVFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKRVVGI 186

Query: 561 AAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHS 382
           A G   S A+   GEVY WG   +G+LG G++  + + P++V  L    + Q+ CG  H+
Sbjct: 187 ACGQTSSMAVLDNGEVYGWGYNGNGQLGLGNN-GNQLTPVRVAALHSVCVNQIVCGYAHT 245

Query: 381 VVLTSDGRIFSY 346
           + LT +G ++++
Sbjct: 246 LALTDEGLLYAW 257



 Score = 75.9 bits (185), Expect = 1e-13
 Identities = 42/139 (30%), Positives = 77/139 (55%), Gaps = 4/139 (2%)
 Frame = -3

Query: 750 RVQGL--EQVSMIAVGAFHNLALSV-DRILWAWGNNEYGQLGIGDTQPRSQPIRV-EGLS 583
           +++GL  +++  ++ G+  ++ LS  D +++AWG+N Y QLG G T     P++V   L 
Sbjct: 67  KLEGLCGKKIKSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLL 126

Query: 582 NLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQV 403
              +V++A G  HS AL  +GEV+AWG    G++G G   +          L  + +V +
Sbjct: 127 IKQVVEVACGSHHSMALAADGEVFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKRVVGI 186

Query: 402 SCGGTHSVVLTSDGRIFSY 346
           +CG T S+ +  +G ++ +
Sbjct: 187 ACGQTSSMAVLDNGEVYGW 205



 Score = 71.2 bits (173), Expect = 3e-12
 Identities = 42/133 (31%), Positives = 76/133 (57%), Gaps = 2/133 (1%)
 Frame = -3

Query: 738 LEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIA 559
           +++V  IA G   ++A+  +  ++ WG N  GQLG+G+   +  P+RV  L ++ +  I 
Sbjct: 180 IKRVVGIACGQTSSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLTPVRVAALHSVCVNQIV 239

Query: 558 AGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQV-SCGGTH- 385
            G  H+ ALT EG +YAWG   +G+LG G +K++ + P  + ++  E +V++ +C   H 
Sbjct: 240 CGYAHTLALTDEGLLYAWGANTYGQLGTG-NKNNLLSPAHI-MVEKERVVEIAACHSAHT 297

Query: 384 SVVLTSDGRIFSY 346
           S   T  G ++ +
Sbjct: 298 SAAKTQGGHVYMW 310



 Score = 68.9 bits (167), Expect = 2e-11
 Identities = 50/191 (26%), Positives = 91/191 (47%), Gaps = 2/191 (1%)
 Frame = -3

Query: 747 VQGLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLV 568
           +  + +  +    A   L ++ +  ++ +G N    LG GD Q    P ++EGL    + 
Sbjct: 18  IASIRKACVFGTSASEALYVTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEGLCGKKIK 77

Query: 567 DIAAG-GWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQV-QLLAGEDIVQVSCG 394
            ++ G G H    T++G VYAWG   + +LG G      + P+QV   L  + +V+V+CG
Sbjct: 78  SLSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTNQG-IAPVQVCTNLLIKQVVEVACG 136

Query: 393 GTHSVVLTSDGRIFSYXXXXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSSEGLWQANYV 214
             HS+ L +DG +F++            +V +G       N P P+  T+   + +   +
Sbjct: 137 SHHSMALAADGEVFAW------GYNNCGQVGSGS----TANQPTPRKVTNCLHIKRVVGI 186

Query: 213 ACGGRHTLAIV 181
           ACG   ++A++
Sbjct: 187 ACGQTSSMAVL 197



 Score = 54.3 bits (129), Expect = 4e-07
 Identities = 32/79 (40%), Positives = 44/79 (55%), Gaps = 2/79 (2%)
 Frame = -3

Query: 729 VSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAA-- 556
           V+ I  G  H LAL+ + +L+AWG N YGQLG G+      P  +  +    +V+IAA  
Sbjct: 235 VNQIVCGYAHTLALTDEGLLYAWGANTYGQLGTGNKNNLLSPAHIM-VEKERVVEIAACH 293

Query: 555 GGWHSAALTKEGEVYAWGR 499
               SAA T+ G VY WG+
Sbjct: 294 SAHTSAAKTQGGHVYMWGQ 312

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>GNEFR_HUMAN (Q9UGK8) Guanine nucleotide exchange factor-related protein|
           (Deafness locus associated putative guanine nucleotide
           exchange factor) (DelGEF)
          Length = 458

 Score = 87.0 bits (214), Expect = 6e-17
 Identities = 61/199 (30%), Positives = 91/199 (45%), Gaps = 14/199 (7%)
 Frame = -3

Query: 735 EQVSMIAVGAFHNLALSVDRILWAWGNNEYG---QLGIGDTQP----RSQPIRVEGLSNL 577
           E+V  IA G  H +A +   I++ WG        +L  G T P      +P RV GL N 
Sbjct: 153 EKVVCIAAGLRHAVAATASGIVFQWGTGLASCGRRLCPGQTLPLFFTAKEPSRVTGLENS 212

Query: 576 SLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVP--LQVQLLAGEDIVQV 403
             + + AG  HSA+LT  GEVY WG  +HG+L   ++ +   VP  ++      E +  +
Sbjct: 213 KAMCVLAGSDHSASLTDAGEVYVWGSNKHGQL--ANEAAFLPVPQKIEAHCFQNEKVTAI 270

Query: 402 SCGGTHSVVLTSDGRIFSYXXXXXXXXXXXRKVTTGHPME-----VPINLPPPKTSTSSE 238
             G TH V  T  G++F++            +   G  +E     +P + PP    +S  
Sbjct: 271 WSGWTHLVAQTETGKMFTWGRADYGQLGRKLETYEGWKLEKQDSFLPCSRPPNSMPSSPH 330

Query: 237 GLWQANYVACGGRHTLAIV 181
            L  A  V+CG  H LAI+
Sbjct: 331 CLTGATEVSCGSEHNLAII 349



 Score = 63.5 bits (153), Expect = 7e-10
 Identities = 38/110 (34%), Positives = 60/110 (54%), Gaps = 2/110 (1%)
 Frame = -3

Query: 672 LWAWGNNEYGQLGIGDTQPRSQPIRVEGLSN-LSLVDIAAGGWHSAALTKEGEVYAWGRG 496
           L+AWG N YGQLG+G  +    P ++       S+  I  GG HSA +T  G+++  G  
Sbjct: 17  LFAWGANSYGQLGLGHKEDVLLPQQLNDFCKPRSVRRITGGGGHSAVVTDGGDLFVCGLN 76

Query: 495 EHGRLGFGDDKS-SHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFS 349
           + G+LG G  +   +  P   + L G  I QV+CG   +++LT +G++ S
Sbjct: 77  KDGQLGLGHTEDIPYFTP--CKSLFGCPIQQVACGWDFTIMLTENGQVLS 124



 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 35/128 (27%), Positives = 60/128 (46%)
 Frame = -3

Query: 729 VSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGG 550
           V  I  G  H+  ++    L+  G N+ GQLG+G T+        + L    +  +A G 
Sbjct: 51  VRRITGGGGHSAVVTDGGDLFVCGLNKDGQLGLGHTEDIPYFTPCKSLFGCPIQQVACGW 110

Query: 549 WHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLT 370
             +  LT+ G+V + G    G+LG        +VP  ++ L  E +V ++ G  H+V  T
Sbjct: 111 DFTIMLTENGQVLSCGSNSFGQLGVPHGPRRCVVPQAIE-LHKEKVVCIAAGLRHAVAAT 169

Query: 369 SDGRIFSY 346
           + G +F +
Sbjct: 170 ASGIVFQW 177



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 39/139 (28%), Positives = 59/139 (42%), Gaps = 18/139 (12%)
 Frame = -3

Query: 735 EQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIG------------------DTQPRS 610
           E+V+ I  G  H +A +    ++ WG  +YGQLG                       P S
Sbjct: 265 EKVTAIWSGWTHLVAQTETGKMFTWGRADYGQLGRKLETYEGWKLEKQDSFLPCSRPPNS 324

Query: 609 QPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQL 430
            P     L+  +  +++ G  H+ A+   G  Y+WG  EHG  G G + ++   P  VQ 
Sbjct: 325 MPSSPHCLTGAT--EVSCGSEHNLAIIG-GVCYSWGWNEHGMCGDGTE-ANVWAPKPVQA 380

Query: 429 LAGEDIVQVSCGGTHSVVL 373
           L     + V CG  HS+ L
Sbjct: 381 LLSSSGLLVGCGAGHSLAL 399



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 37/132 (28%), Positives = 55/132 (41%), Gaps = 6/132 (4%)
 Frame = -3

Query: 729 VSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGG 550
           +  +A G    + L+ +  + + G+N +GQLG+     R    +   L    +V IAAG 
Sbjct: 103 IQQVACGWDFTIMLTENGQVLSCGSNSFGQLGVPHGPRRCVVPQAIELHKEKVVCIAAGL 162

Query: 549 WHSAALTKEGEVYAWGRGEHG---RLGFGDDKSSHMV---PLQVQLLAGEDIVQVSCGGT 388
            H+ A T  G V+ WG G      RL  G           P +V  L     + V  G  
Sbjct: 163 RHAVAATASGIVFQWGTGLASCGRRLCPGQTLPLFFTAKEPSRVTGLENSKAMCVLAGSD 222

Query: 387 HSVVLTSDGRIF 352
           HS  LT  G ++
Sbjct: 223 HSASLTDAGEVY 234



 Score = 36.6 bits (83), Expect = 0.085
 Identities = 20/65 (30%), Positives = 33/65 (50%), Gaps = 1/65 (1%)
 Frame = -3

Query: 543 SAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQV-QLLAGEDIVQVSCGGTHSVVLTS 367
           S A      ++AWG   +G+LG G  K   ++P Q+        + +++ GG HS V+T 
Sbjct: 8   SEAAPAAAALFAWGANSYGQLGLG-HKEDVLLPQQLNDFCKPRSVRRITGGGGHSAVVTD 66

Query: 366 DGRIF 352
            G +F
Sbjct: 67  GGDLF 71

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>RPGR_CANFA (Q9N1T2) X-linked retinitis pigmentosa GTPase regulator|
          Length = 1003

 Score = 85.9 bits (211), Expect = 1e-16
 Identities = 57/185 (30%), Positives = 93/185 (50%), Gaps = 1/185 (0%)
 Frame = -3

Query: 735 EQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGL-SNLSLVDIA 559
           E+V   A G  H L  +    ++A G N  GQLG+GDT+ RS    +    S   +  ++
Sbjct: 87  EKVKFAACGRNHTLVSTEGGKVYAAGGNNEGQLGLGDTEERSTFHLISFFTSQRKIKQLS 146

Query: 558 AGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSV 379
           AG   SAALT++GE++ WG    G++G  ++ ++  VP QV +  G+ I  +SCG  HS 
Sbjct: 147 AGSNTSAALTEDGELFMWGDNSEGQIGL-ENVTNVCVPQQVTV--GKPISWISCGYYHSA 203

Query: 378 VLTSDGRIFSYXXXXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGR 199
            +T++G+++++            ++   H M  P+   P K             VACGG 
Sbjct: 204 FVTTEGQLYTFGEPECGKLGLPNQLLVNHRMPQPVPGIPGKVV----------QVACGGG 253

Query: 198 HTLAI 184
           HT+ +
Sbjct: 254 HTVVL 258



 Score = 70.1 bits (170), Expect = 7e-12
 Identities = 46/183 (25%), Positives = 77/183 (42%)
 Frame = -3

Query: 726 SMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGW 547
           + ++ G  H   ++ +  L+ +G+N +GQLG+G     S+P  V+ L    +   A G  
Sbjct: 38  TFLSCGDEHTAVVTGNNKLYMFGSNNWGQLGLGSKSTVSKPTCVKALKPEKVKFAACGRN 97

Query: 546 HSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTS 367
           H+   T+ G+VYA G    G+LG GD +      L     +   I Q+S G   S  LT 
Sbjct: 98  HTLVSTEGGKVYAAGGNNEGQLGLGDTEERSTFHLISFFTSQRKIKQLSAGSNTSAALTE 157

Query: 366 DGRIFSYXXXXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGRHTLA 187
           DG +F +                  P +V +  P              ++++CG  H+  
Sbjct: 158 DGELFMWGDNSEGQIGLENVTNVCVPQQVTVGKP-------------ISWISCGYYHSAF 204

Query: 186 IVT 178
           + T
Sbjct: 205 VTT 207



 Score = 66.6 bits (161), Expect = 8e-11
 Identities = 47/186 (25%), Positives = 87/186 (46%), Gaps = 2/186 (1%)
 Frame = -3

Query: 729 VSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQ--PRSQPIRVEGLSNLSLVDIAA 556
           +S I+ G +H+  ++ +  L+ +G  E G+LG+ +        P  V G+    +V +A 
Sbjct: 192 ISWISCGYYHSAFVTTEGQLYTFGEPECGKLGLPNQLLVNHRMPQPVPGIPG-KVVQVAC 250

Query: 555 GGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVV 376
           GG H+  LT++  VY +G G+ G+LG G       VP  ++ +  + I  ++CG  H+ +
Sbjct: 251 GGGHTVVLTEKA-VYTFGLGQFGQLGLGTFLFETSVPKAIEHIKDQKISFIACGENHTAL 309

Query: 375 LTSDGRIFSYXXXXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGRH 196
           +T  G ++++            + +T   +          T  S+   +    V+CGG H
Sbjct: 310 ITDMGLMYTFGDGRHGKLGLGLENSTNQFI---------PTLCSNFLRFIVQLVSCGGCH 360

Query: 195 TLAIVT 178
           TL   T
Sbjct: 361 TLVFAT 366



 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 37/124 (29%), Positives = 67/124 (54%), Gaps = 2/124 (1%)
 Frame = -3

Query: 732 QVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQ-PRSQPIRVEGLSNLSLVDIAA 556
           +V  +A G  H + L+ ++ ++ +G  ++GQLG+G      S P  +E + +  +  IA 
Sbjct: 244 KVVQVACGGGHTVVLT-EKAVYTFGLGQFGQLGLGTFLFETSVPKAIEHIKDQKISFIAC 302

Query: 555 GGWHSAALTKEGEVYAWGRGEHGRLGFG-DDKSSHMVPLQVQLLAGEDIVQVSCGGTHSV 379
           G  H+A +T  G +Y +G G HG+LG G ++ ++  +P          +  VSCGG H++
Sbjct: 303 GENHTALITDMGLMYTFGDGRHGKLGLGLENSTNQFIPTLCSNFLRFIVQLVSCGGCHTL 362

Query: 378 VLTS 367
           V  +
Sbjct: 363 VFAT 366

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>NEK8_HUMAN (Q86SG6) Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never|
           in mitosis A-related kinase 8) (NimA-related protein
           kinase 8) (NIMA-related kinase 12a)
          Length = 692

 Score = 84.3 bits (207), Expect = 4e-16
 Identities = 47/124 (37%), Positives = 67/124 (54%)
 Frame = -3

Query: 729 VSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGG 550
           +  +A G F    L+   I+  +G+   G LG G     SQP  VE L    +V +A G 
Sbjct: 393 IKHVACGDFFTACLTDRGIIMTFGSGSNGCLGHGSLTDISQPTIVEALLGYEMVQVACGA 452

Query: 549 WHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLT 370
            H  AL+ E E++AWGRG+ GRLG G  + SH  P QV +  G++  +V CG   S++LT
Sbjct: 453 SHVLALSTERELFAWGRGDSGRLGLG-TRESHSCPQQVPMPPGQEAQRVVCGIDSSMILT 511

Query: 369 SDGR 358
             G+
Sbjct: 512 VPGQ 515



 Score = 71.2 bits (173), Expect = 3e-12
 Identities = 35/113 (30%), Positives = 60/113 (53%)
 Frame = -3

Query: 735 EQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAA 556
           E +  I +G  H+ A++     + +G+N++GQLG    +    P +V+GL  + +  +A 
Sbjct: 561 EPLLSIDLGTAHSAAVTASGDCYTFGSNQHGQLGTNTRRGSRAPCKVQGLEGIKMAMVAC 620

Query: 555 GGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSC 397
           G   + A+  E EVY+WG+G  GRLG  D+ +    P+Q+       +  VSC
Sbjct: 621 GDAFTVAIGAESEVYSWGKGARGRLGRRDEDAGLPRPVQLDETHPYTVTSVSC 673



 Score = 59.7 bits (143), Expect = 9e-09
 Identities = 55/199 (27%), Positives = 81/199 (40%), Gaps = 13/199 (6%)
 Frame = -3

Query: 741  GLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDI 562
            G E V  +A GA H LALS +R L+AWG  + G+LG+G  +  S P +V          +
Sbjct: 442  GYEMVQ-VACGASHVLALSTERELFAWGRGDSGRLGLGTRESHSCPQQVPMPPGQEAQRV 500

Query: 561  AAGGWHSAALTKEGEVYAWGRGEHGRLG-----FGDDKSSHM---VPLQVQLLAG----- 421
              G   S  LT  G+  A G     +LG      G++   H      L   LL       
Sbjct: 501  VCGIDSSMILTVPGQALACGSNRFNKLGLDHLSLGEEPVPHQQVEEALSFTLLGSAPLDQ 560

Query: 420  EDIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSS 241
            E ++ +  G  HS  +T+ G  +++            +  +  P +V             
Sbjct: 561  EPLLSIDLGTAHSAAVTASGDCYTFGSNQHGQLGTNTRRGSRAPCKV----------QGL 610

Query: 240  EGLWQANYVACGGRHTLAI 184
            EG+  A  VACG   T+AI
Sbjct: 611  EGIKMA-MVACGDAFTVAI 628



 Score = 59.7 bits (143), Expect = 9e-09
 Identities = 40/141 (28%), Positives = 70/141 (49%), Gaps = 2/141 (1%)
 Frame = -3

Query: 621 QPRSQPIR--VEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMV 448
           QP+ Q I   +EG S +++  +A G + +A LT  G +  +G G +G LG G   +    
Sbjct: 375 QPQPQFISRFLEGQSGVTIKHVACGDFFTACLTDRGIIMTFGSGSNGCLGHGS-LTDISQ 433

Query: 447 PLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXRKVTTGHPMEVPINL 268
           P  V+ L G ++VQV+CG +H + L+++  +F++            + +   P +VP  +
Sbjct: 434 PTIVEALLGYEMVQVACGASHVLALSTERELFAWGRGDSGRLGLGTRESHSCPQQVP--M 491

Query: 267 PPPKTSTSSEGLWQANYVACG 205
           PP +         +A  V CG
Sbjct: 492 PPGQ---------EAQRVVCG 503



 Score = 38.5 bits (88), Expect = 0.022
 Identities = 45/173 (26%), Positives = 68/173 (39%), Gaps = 8/173 (4%)
 Frame = -3

Query: 672 LWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAW---- 505
           ++AWG       G+G       P+R+  L N  +V +AAG    A +T+ G +  W    
Sbjct: 314 VYAWGG------GLGT------PLRLPML-NTEVVQVAAGRTQKAGVTRSGRLILWEAPP 360

Query: 504 -GRGEHGRL-GFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSYXXXXX 331
            G G    L G  +      +   ++  +G  I  V+CG   +  LT  G I ++     
Sbjct: 361 LGAGGGSLLPGAVEQPQPQFISRFLEGQSGVTIKHVACGDFFTACLTDRGIIMTFGSGSN 420

Query: 330 XXXXXXRKVTTGHPMEVPINLPPPKTSTSSEGL--WQANYVACGGRHTLAIVT 178
                      GH     I+ P     T  E L  ++   VACG  H LA+ T
Sbjct: 421 G--------CLGHGSLTDISQP-----TIVEALLGYEMVQVACGASHVLALST 460

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>RPGR_MOUSE (Q9R0X5) X-linked retinitis pigmentosa GTPase regulator (mRpgr)|
          Length = 1001

 Score = 80.9 bits (198), Expect = 4e-15
 Identities = 58/186 (31%), Positives = 95/186 (51%), Gaps = 2/186 (1%)
 Frame = -3

Query: 735 EQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLV-DIA 559
           E+V + A G  H L  +    ++A G N  GQLG+GDT  R    ++   +    +  ++
Sbjct: 87  EKVKLAACGRNHTLVSTDTGGVYAAGGNNEGQLGLGDTDDRDTFHQIVFFTPADTIKQLS 146

Query: 558 AGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSV 379
           AG   SAALT++G+++ WG    G++G  +DKS+  +P +V +  G+ I  +SCG  HS 
Sbjct: 147 AGANTSAALTEDGKLFMWGDNSEGQIGL-EDKSNVCIPHEVTV--GKPISWISCGYYHSA 203

Query: 378 VLTSDGRIFSYXXXXXXXXXXXRKVTTGHPMEVPIN-LPPPKTSTSSEGLWQANYVACGG 202
            +T DG ++++                G P E+ +N   P +     E + Q   VACGG
Sbjct: 204 FVTMDGELYTFGEPENG--------KLGLPNELLMNHRSPQRVLGIPERVIQ---VACGG 252

Query: 201 RHTLAI 184
            HT+ +
Sbjct: 253 GHTVVL 258



 Score = 70.5 bits (171), Expect = 5e-12
 Identities = 53/186 (28%), Positives = 88/186 (47%), Gaps = 2/186 (1%)
 Frame = -3

Query: 729 VSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDT--QPRSQPIRVEGLSNLSLVDIAA 556
           +S I+ G +H+  +++D  L+ +G  E G+LG+ +        P RV G+    ++ +A 
Sbjct: 192 ISWISCGYYHSAFVTMDGELYTFGEPENGKLGLPNELLMNHRSPQRVLGIPE-RVIQVAC 250

Query: 555 GGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVV 376
           GG H+  LT E  VYA+G G+ G+LG G        P  ++ +  + I  +SCG  H+ +
Sbjct: 251 GGGHTVVLT-EKVVYAFGLGQFGQLGLGTFLFETSEPKIIERIKDQKICHISCGENHTAL 309

Query: 375 LTSDGRIFSYXXXXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGRH 196
           +T  G ++++                G  ME   N   P T  S+   +    +ACGG H
Sbjct: 310 MTELGLLYTFGDGRHG--------KLGLGMENFTNQFFP-TLCSNFLRFAVQLIACGGCH 360

Query: 195 TLAIVT 178
            L   T
Sbjct: 361 MLVFAT 366



 Score = 65.9 bits (159), Expect = 1e-10
 Identities = 47/173 (27%), Positives = 72/173 (41%)
 Frame = -3

Query: 720 IAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHS 541
           ++ G  H   ++ +  L+ +G+N +GQLG+G      +P  ++ L    +   A G  H+
Sbjct: 40  LSCGDEHTAIVTGNNKLYMFGSNNWGQLGLGSKAAIIKPTCIKALKPEKVKLAACGRNHT 99

Query: 540 AALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDG 361
              T  G VYA G    G+LG GD          V     + I Q+S G   S  LT DG
Sbjct: 100 LVSTDTGGVYAAGGNNEGQLGLGDTDDRDTFHQIVFFTPADTIKQLSAGANTSAALTEDG 159

Query: 360 RIFSYXXXXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGG 202
           ++F +            K     P EV +  P    S  S G + + +V   G
Sbjct: 160 KLFMWGDNSEGQIGLEDKSNVCIPHEVTVGKP---ISWISCGYYHSAFVTMDG 209

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>RPGR_HUMAN (Q92834) X-linked retinitis pigmentosa GTPase regulator|
          Length = 1020

 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 54/185 (29%), Positives = 89/185 (48%), Gaps = 1/185 (0%)
 Frame = -3

Query: 735 EQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGL-SNLSLVDIA 559
           E+V + A G  H L  +    ++A G N  GQLG+GDT+ R+    +    S   +  ++
Sbjct: 87  EKVKLAACGRNHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLS 146

Query: 558 AGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSV 379
           AG   SAALT++G ++ WG    G++G   + S+  VP QV +  G+ +  +SCG  HS 
Sbjct: 147 AGSNTSAALTEDGRLFMWGDNSEGQIGL-KNVSNVCVPQQVTI--GKPVSWISCGYYHSA 203

Query: 378 VLTSDGRIFSYXXXXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGR 199
            +T+DG ++ +            ++   H     ++  P K             VACGG 
Sbjct: 204 FVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEIPEKVI----------QVACGGE 253

Query: 198 HTLAI 184
           HT+ +
Sbjct: 254 HTVVL 258



 Score = 71.2 bits (173), Expect = 3e-12
 Identities = 47/181 (25%), Positives = 78/181 (43%)
 Frame = -3

Query: 720 IAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHS 541
           ++ G  H+  ++ +  L+ +G+N +GQLG+G     S+P  V+ L    +   A G  H+
Sbjct: 40  LSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHT 99

Query: 540 AALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDG 361
              T+ G VYA G    G+LG GD +  +   +     +   I Q+S G   S  LT DG
Sbjct: 100 LVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDG 159

Query: 360 RIFSYXXXXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGRHTLAIV 181
           R+F +                  P +V I  P              ++++CG  H+  + 
Sbjct: 160 RLFMWGDNSEGQIGLKNVSNVCVPQQVTIGKP-------------VSWISCGYYHSAFVT 206

Query: 180 T 178
           T
Sbjct: 207 T 207



 Score = 67.4 bits (163), Expect = 5e-11
 Identities = 39/128 (30%), Positives = 70/128 (54%), Gaps = 2/128 (1%)
 Frame = -3

Query: 735 EQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQ-PRSQPIRVEGLSNLSLVDIA 559
           E+V  +A G  H + L+ +  ++ +G  ++GQLG+G      S+P  +E + + ++  I+
Sbjct: 243 EKVIQVACGGEHTVVLT-ENAVYTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYIS 301

Query: 558 AGGWHSAALTKEGEVYAWGRGEHGRLGFG-DDKSSHMVPLQVQLLAGEDIVQVSCGGTHS 382
            G  H+A +T  G +Y +G G HG+LG G ++ ++H +P          +  V+CGG H 
Sbjct: 302 CGENHTALITDIGLMYTFGDGRHGKLGLGLENFTNHFIPTLCSNFLRFIVKLVACGGCHM 361

Query: 381 VVLTSDGR 358
           VV  +  R
Sbjct: 362 VVFAAPHR 369



 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 47/180 (26%), Positives = 82/180 (45%), Gaps = 2/180 (1%)
 Frame = -3

Query: 729 VSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQ--PIRVEGLSNLSLVDIAA 556
           VS I+ G +H+  ++ D  L+ +G  E G+LG+ +    +   P  V  +    ++ +A 
Sbjct: 192 VSWISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEIPE-KVIQVAC 250

Query: 555 GGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVV 376
           GG H+  LT E  VY +G G+ G+LG G        P  ++ +  + I  +SCG  H+ +
Sbjct: 251 GGEHTVVLT-ENAVYTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGENHTAL 309

Query: 375 LTSDGRIFSYXXXXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGRH 196
           +T  G ++++            +  T H +          T  S+   +    VACGG H
Sbjct: 310 ITDIGLMYTFGDGRHGKLGLGLENFTNHFI---------PTLCSNFLRFIVKLVACGGCH 360



 Score = 46.6 bits (109), Expect = 8e-05
 Identities = 24/74 (32%), Positives = 40/74 (54%)
 Frame = -3

Query: 570 VDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGG 391
           V ++ G  HSA +T   ++Y +G    G+LG G  KS+   P  V+ L  E +   +CG 
Sbjct: 38  VHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLG-SKSAISKPTCVKALKPEKVKLAACGR 96

Query: 390 THSVVLTSDGRIFS 349
            H++V T  G +++
Sbjct: 97  NHTLVSTEGGNVYA 110

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>RPGRH_CAEEL (Q5DX34) X-linked retinitis pigmentosa GTPase regulator homolog|
          Length = 1392

 Score = 76.6 bits (187), Expect = 7e-14
 Identities = 47/123 (38%), Positives = 72/123 (58%), Gaps = 1/123 (0%)
 Frame = -3

Query: 720  IAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHS 541
            IA GA H L LS    L AWG N +GQ G+G +   +   +V+G    ++  IA G +HS
Sbjct: 781  IACGAEHILVLSSSGQLSAWGGNRFGQCGVGHSFRIANLHQVDG-DWPAIEKIACGQFHS 839

Query: 540  AALTKEGEVYAWGRGEHGRLGFGD-DKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSD 364
            A +  +G ++ +G G  G+LG G  + S+ +VP +V  L  + + Q++CG  H+VVLT  
Sbjct: 840  AFICSDGSLWTFGWGVWGQLGHGGRNNSNQLVPTRVNGLICK-VTQIACGRAHTVVLTDT 898

Query: 363  GRI 355
            GR+
Sbjct: 899  GRV 901



 Score = 67.0 bits (162), Expect = 6e-11
 Identities = 46/132 (34%), Positives = 63/132 (47%), Gaps = 4/132 (3%)
 Frame = -3

Query: 729  VSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQ--PIRVEGLSNLSLVDIAA 556
            +  IA G FH+  +  D  LW +G   +GQLG G     +Q  P RV GL    +  IA 
Sbjct: 829  IEKIACGQFHSAFICSDGSLWTFGWGVWGQLGHGGRNNSNQLVPTRVNGLI-CKVTQIAC 887

Query: 555  GGWHSAALTKEGEVYAWGRGEHGRLGFGDD--KSSHMVPLQVQLLAGEDIVQVSCGGTHS 382
            G  H+  LT  G V   G G +G++G  DD  K     PL +  L   DI   +    HS
Sbjct: 888  GRAHTVVLTDTGRVLVCGSGSYGQMGVDDDIKKVFAFTPLPLGPLRVRDI---ATHYYHS 944

Query: 381  VVLTSDGRIFSY 346
            + +T D R+F +
Sbjct: 945  ICITEDNRVFEW 956



 Score = 59.7 bits (143), Expect = 9e-09
 Identities = 31/77 (40%), Positives = 45/77 (58%)
 Frame = -3

Query: 576  SLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSC 397
            ++V +A G  HSA +T EG +Y WG+G   +LG G +K+  M P QV    G   V VS 
Sbjct: 1023 NIVSVACGLSHSALITSEGTLYTWGKGLDYQLGHG-NKNERMEPHQVFEPNGAKWVNVSL 1081

Query: 396  GGTHSVVLTSDGRIFSY 346
            G  H++  T DG +F++
Sbjct: 1082 GNNHTIASTDDGSVFAW 1098



 Score = 53.5 bits (127), Expect = 7e-07
 Identities = 25/81 (30%), Positives = 44/81 (54%)
 Frame = -3

Query: 720  IAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHS 541
            +A G  H+  ++ +  L+ WG     QLG G+   R +P +V   +    V+++ G  H+
Sbjct: 1027 VACGLSHSALITSEGTLYTWGKGLDYQLGHGNKNERMEPHQVFEPNGAKWVNVSLGNNHT 1086

Query: 540  AALTKEGEVYAWGRGEHGRLG 478
             A T +G V+AWG+ + G+ G
Sbjct: 1087 IASTDDGSVFAWGKNDFGQCG 1107



 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 44/173 (25%), Positives = 74/173 (42%), Gaps = 38/173 (21%)
 Frame = -3

Query: 750  RVQGLE-QVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLS 574
            RV GL  +V+ IA G  H + L+    +   G+  YGQ+G+ D   +        L  L 
Sbjct: 874  RVNGLICKVTQIACGRAHTVVLTDTGRVLVCGSGSYGQMGVDDDIKKVFAFTPLPLGPLR 933

Query: 573  LVDIAAGGWHSAALTKEGEVYAWGRG--------------EHGRLGFGDDKSSHM----- 451
            + DIA   +HS  +T++  V+ WGR                  +L   +D SS       
Sbjct: 934  VRDIATHYYHSICITEDNRVFEWGRNPQELKMRMFVMKKIRSAQLKNTEDPSSPSPSTNG 993

Query: 450  ------------VP------LQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSY 346
                        +P       +V+     +IV V+CG +HS ++TS+G ++++
Sbjct: 994  STPRVNLNLPAEIPREDLGLREVKHFLDGNIVSVACGLSHSALITSEGTLYTW 1046



 Score = 32.0 bits (71), Expect = 2.1
 Identities = 11/30 (36%), Positives = 21/30 (70%)
 Frame = -3

Query: 720  IAVGAFHNLALSVDRILWAWGNNEYGQLGI 631
            +++G  H +A + D  ++AWG N++GQ G+
Sbjct: 1079 VSLGNNHTIASTDDGSVFAWGKNDFGQCGV 1108

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>ALS2_PANTR (Q5BIW4) Alsin (Amyotrophic lateral sclerosis protein 2 homolog)|
          Length = 1657

 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 37/100 (37%), Positives = 58/100 (58%)
 Frame = -3

Query: 672 LWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGE 493
           +W WG  + GQLG GD  PR QP+ V+ L    ++ + AGG+HS ALT + +VY+WG   
Sbjct: 528 VWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSNT 587

Query: 492 HGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVL 373
            G+LG  D  ++  VP   ++ +   +  V+ G  +S+ L
Sbjct: 588 FGQLGHSDFPTT--VPRLAKISSENGVWSVAAGRDYSLFL 625



 Score = 57.8 bits (138), Expect = 4e-08
 Identities = 36/122 (29%), Positives = 61/122 (50%)
 Frame = -3

Query: 519 EVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSYXX 340
           EV+ WG+G+ G+LG GD     + PL V+ L G++++ +  GG HS+ LT+  +++S+  
Sbjct: 527 EVWTWGKGKEGQLGHGD-VLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGS 585

Query: 339 XXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGRHTLAIVTWTDM*L 160
                         GH  + P  +P     +S  G+W    VA G  ++L +V   D   
Sbjct: 586 NTFG--------QLGH-SDFPTTVPRLAKISSENGVWS---VAAGRDYSLFLVDTEDFQP 633

Query: 159 GI 154
           G+
Sbjct: 634 GL 635



 Score = 51.6 bits (122), Expect = 3e-06
 Identities = 47/193 (24%), Positives = 82/193 (42%), Gaps = 6/193 (3%)
 Frame = -3

Query: 741 GLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDI 562
           G + V   A+G  H + L+ D  ++++G   + + G  +  P S PI    L    +V +
Sbjct: 39  GGKTVLQAALGVKHGVLLTEDGEVYSFGTLPW-RSGPVEICP-SSPILENALVGQYVVTV 96

Query: 561 AAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDK------SSHMVPLQVQLLAGEDIVQVS 400
           A G +HS A+T  G  Y WG    G+    + +         +   +   L    I+Q++
Sbjct: 97  ATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLA 156

Query: 399 CGGTHSVVLTSDGRIFSYXXXXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSSEGLWQAN 220
           CG  H++ L+    I+++             +TT      P+  P      +   + Q  
Sbjct: 157 CGEEHTLALSISREIWAWGTGCQLGL-----ITTA----FPVTKPQKVEHLAGRVVLQ-- 205

Query: 219 YVACGGRHTLAIV 181
            VACG  H+LA+V
Sbjct: 206 -VACGAFHSLALV 217



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 42/160 (26%), Positives = 64/160 (40%), Gaps = 7/160 (4%)
 Frame = -3

Query: 606 PIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLL 427
           P R+ G    +++  A G  H   LT++GEVY++G         G  +     P+    L
Sbjct: 32  PERLPGWGGKTVLQAALGVKHGVLLTEDGEVYSFGTLPWRS---GPVEICPSSPILENAL 88

Query: 426 AGEDIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXRKVTTGHPMEVPINLPPPKTST 247
            G+ +V V+ G  HS  +T +G  + +            +     P  V I      +  
Sbjct: 89  VGQYVVTVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSI----ADSEA 144

Query: 246 SSEGLWQANYVACGGRHTLA------IVTW-TDM*LGIIT 148
           S     +   +ACG  HTLA      I  W T   LG+IT
Sbjct: 145 SPLLAVRILQLACGEEHTLALSISREIWAWGTGCQLGLIT 184



 Score = 38.9 bits (89), Expect = 0.017
 Identities = 22/68 (32%), Positives = 38/68 (55%)
 Frame = -3

Query: 735 EQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAA 556
           ++V  +  G +H+LAL+    +++WG+N +GQLG  D  P + P   +  S   +  +AA
Sbjct: 559 KEVIHLEAGGYHSLALTAKSQVYSWGSNTFGQLGHSDF-PTTVPRLAKISSENGVWSVAA 617

Query: 555 GGWHSAAL 532
           G  +S  L
Sbjct: 618 GRDYSLFL 625



 Score = 32.7 bits (73), Expect = 1.2
 Identities = 17/61 (27%), Positives = 29/61 (47%)
 Frame = -3

Query: 528 KEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFS 349
           K     A G  E G +      S  + P ++    G+ ++Q + G  H V+LT DG ++S
Sbjct: 5   KRSSTEAEGSKERGLVHIWQAGSFPITPERLPGWGGKTVLQAALGVKHGVLLTEDGEVYS 64

Query: 348 Y 346
           +
Sbjct: 65  F 65

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>RCC1_CANAL (P52499) Protein RCC1|
          Length = 464

 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 48/149 (32%), Positives = 75/149 (50%), Gaps = 17/149 (11%)
 Frame = -3

Query: 741 GLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGI----GDTQPRS---QPIRVEGLS 583
           GL  +  IA G FH  A+     ++AWG N+YGQ  +    G+ +  S   +P  +  LS
Sbjct: 249 GLYNIKYIASGDFHCFAIDHSHNVYAWGLNQYGQCALTGDNGELEDGSVLMKPTLIPELS 308

Query: 582 NLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDK----------SSHMVPLQVQ 433
           +  + +IAAG  H+ ALT++G+VYAWGR +   +G   DK           +H     +Q
Sbjct: 309 HKGIKEIAAGEHHTLALTEDGQVYAWGRYDMKEIGIPKDKLPKSTFKINTGTHGSFSFLQ 368

Query: 432 LLAGEDIVQVSCGGTHSVVLTSDGRIFSY 346
            L    I  +  G  HS  +T DG ++++
Sbjct: 369 NLFAVKIKTIGVGSHHSFAVTEDGVVYAW 397



 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 38/130 (29%), Positives = 58/130 (44%), Gaps = 13/130 (10%)
 Frame = -3

Query: 729 VSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRV-----------EGLS 583
           +  IA G  H LAL+ D  ++AWG  +  ++GI   +      ++           + L 
Sbjct: 312 IKEIAAGEHHTLALTEDGQVYAWGRYDMKEIGIPKDKLPKSTFKINTGTHGSFSFLQNLF 371

Query: 582 NLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLA--GEDIV 409
            + +  I  G  HS A+T++G VYAWG  E    G G        P ++   A   EDI+
Sbjct: 372 AVKIKTIGVGSHHSFAVTEDGVVYAWGFAETYGPGLGPSIDDVEKPTRIVNTATKNEDIL 431

Query: 408 QVSCGGTHSV 379
            +  GG  SV
Sbjct: 432 LIGAGGQFSV 441



 Score = 50.4 bits (119), Expect = 6e-06
 Identities = 40/127 (31%), Positives = 52/127 (40%), Gaps = 30/127 (23%)
 Frame = -3

Query: 717 AVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPR------------------------- 613
           AVG  H LAL     +W+WG N+   LG    Q +                         
Sbjct: 71  AVGGMHTLALDGKNRIWSWGGNDSEVLGRDTCQAKEVLKDIDGKNGNDDDDDDEDGDLNE 130

Query: 612 --SQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWG--RGEHGRLGF-GDDKSSHMV 448
             S P  VE L    +V +AA    SAAL   G+VY+WG  R   G LGF  D+      
Sbjct: 131 AESTPALVENLPEGEIVQLAATDNLSAALLSNGDVYSWGCFRCNEGLLGFLRDEIKLQKT 190

Query: 447 PLQVQLL 427
           PL+++ L
Sbjct: 191 PLKIKEL 197



 Score = 46.6 bits (109), Expect = 8e-05
 Identities = 35/143 (24%), Positives = 58/143 (40%), Gaps = 34/143 (23%)
 Frame = -3

Query: 672 LWAWGNNEYGQLGIGDT-------QPRSQP-IRVEGLSNLSLVDIAAGGWHSAALTKEGE 517
           ++ WG     +LG+G +       +PR  P +  E L    +VD A GG H+ AL  +  
Sbjct: 26  VFVWGTGSMCELGLGPSAKNKEVKRPRLNPYLTEEKLGGTKIVDFAVGGMHTLALDGKNR 85

Query: 516 VYAWGRGEHGRLG--------------------------FGDDKSSHMVPLQVQLLAGED 415
           +++WG  +   LG                           GD   +   P  V+ L   +
Sbjct: 86  IWSWGGNDSEVLGRDTCQAKEVLKDIDGKNGNDDDDDDEDGDLNEAESTPALVENLPEGE 145

Query: 414 IVQVSCGGTHSVVLTSDGRIFSY 346
           IVQ++     S  L S+G ++S+
Sbjct: 146 IVQLAATDNLSAALLSNGDVYSW 168



 Score = 34.7 bits (78), Expect = 0.32
 Identities = 20/65 (30%), Positives = 29/65 (44%), Gaps = 7/65 (10%)
 Frame = -3

Query: 519 EVYAWGRGEHGRLGFGDDKSSHMVP-------LQVQLLAGEDIVQVSCGGTHSVVLTSDG 361
           +V+ WG G    LG G    +  V        L  + L G  IV  + GG H++ L    
Sbjct: 25  DVFVWGTGSMCELGLGPSAKNKEVKRPRLNPYLTEEKLGGTKIVDFAVGGMHTLALDGKN 84

Query: 360 RIFSY 346
           RI+S+
Sbjct: 85  RIWSW 89



 Score = 32.7 bits (73), Expect = 1.2
 Identities = 20/69 (28%), Positives = 36/69 (52%), Gaps = 3/69 (4%)
 Frame = -3

Query: 732 QVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDT-QPRSQPIRV--EGLSNLSLVDI 562
           ++  I VG+ H+ A++ D +++AWG  E    G+G +     +P R+      N  ++ I
Sbjct: 374 KIKTIGVGSHHSFAVTEDGVVYAWGFAETYGPGLGPSIDDVEKPTRIVNTATKNEDILLI 433

Query: 561 AAGGWHSAA 535
            AGG  S +
Sbjct: 434 GAGGQFSVS 442

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>ALS2_HUMAN (Q96Q42) Alsin (Amyotrophic lateral sclerosis protein 2)|
          Length = 1657

 Score = 75.9 bits (185), Expect = 1e-13
 Identities = 36/100 (36%), Positives = 58/100 (58%)
 Frame = -3

Query: 672 LWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGE 493
           +W WG  + GQLG GD  PR QP+ V+ L    ++ + AGG+HS ALT + +VY+WG   
Sbjct: 528 VWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSNT 587

Query: 492 HGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVL 373
            G+LG  D  ++  VP   ++ +   +  ++ G  +S+ L
Sbjct: 588 FGQLGHSDFPTT--VPRLAKISSENGVWSIAAGRDYSLFL 625



 Score = 57.4 bits (137), Expect = 5e-08
 Identities = 35/122 (28%), Positives = 61/122 (50%)
 Frame = -3

Query: 519 EVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSYXX 340
           EV+ WG+G+ G+LG GD     + PL V+ L G++++ +  GG HS+ LT+  +++S+  
Sbjct: 527 EVWTWGKGKEGQLGHGD-VLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGS 585

Query: 339 XXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGRHTLAIVTWTDM*L 160
                         GH  + P  +P     +S  G+W    +A G  ++L +V   D   
Sbjct: 586 NTFG--------QLGH-SDFPTTVPRLAKISSENGVWS---IAAGRDYSLFLVDTEDFQP 633

Query: 159 GI 154
           G+
Sbjct: 634 GL 635



 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 46/193 (23%), Positives = 82/193 (42%), Gaps = 6/193 (3%)
 Frame = -3

Query: 741 GLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDI 562
           G + V   A+G  H + L+ D  ++++G   + + G  +  P S PI    L    ++ +
Sbjct: 39  GGKTVLQAALGVKHGVLLTEDGEVYSFGTLPW-RSGPVEICP-SSPILENALVGQYVITV 96

Query: 561 AAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDK------SSHMVPLQVQLLAGEDIVQVS 400
           A G +HS A+T  G  Y WG    G+    + +         +   +   L    I+Q++
Sbjct: 97  ATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLA 156

Query: 399 CGGTHSVVLTSDGRIFSYXXXXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSSEGLWQAN 220
           CG  H++ L+    I+++             +TT      P+  P      +   + Q  
Sbjct: 157 CGEEHTLALSISREIWAWGTGCQLGL-----ITTA----FPVTKPQKVEHLAGRVVLQ-- 205

Query: 219 YVACGGRHTLAIV 181
            VACG  H+LA+V
Sbjct: 206 -VACGAFHSLALV 217



 Score = 40.8 bits (94), Expect = 0.005
 Identities = 41/160 (25%), Positives = 64/160 (40%), Gaps = 7/160 (4%)
 Frame = -3

Query: 606 PIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLL 427
           P R+ G    +++  A G  H   LT++GEVY++G         G  +     P+    L
Sbjct: 32  PERLPGWGGKTVLQAALGVKHGVLLTEDGEVYSFGTLPWRS---GPVEICPSSPILENAL 88

Query: 426 AGEDIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXRKVTTGHPMEVPINLPPPKTST 247
            G+ ++ V+ G  HS  +T +G  + +            +     P  V I      +  
Sbjct: 89  VGQYVITVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSI----ADSEA 144

Query: 246 SSEGLWQANYVACGGRHTLA------IVTW-TDM*LGIIT 148
           S     +   +ACG  HTLA      I  W T   LG+IT
Sbjct: 145 SPLLAVRILQLACGEEHTLALSISREIWAWGTGCQLGLIT 184



 Score = 39.3 bits (90), Expect = 0.013
 Identities = 23/68 (33%), Positives = 38/68 (55%)
 Frame = -3

Query: 735 EQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAA 556
           ++V  +  G +H+LAL+    +++WG+N +GQLG  D  P + P   +  S   +  IAA
Sbjct: 559 KEVIHLEAGGYHSLALTAKSQVYSWGSNTFGQLGHSDF-PTTVPRLAKISSENGVWSIAA 617

Query: 555 GGWHSAAL 532
           G  +S  L
Sbjct: 618 GRDYSLFL 625



 Score = 32.7 bits (73), Expect = 1.2
 Identities = 17/61 (27%), Positives = 29/61 (47%)
 Frame = -3

Query: 528 KEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFS 349
           K     A G  E G +      S  + P ++    G+ ++Q + G  H V+LT DG ++S
Sbjct: 5   KRSSTEAEGSKERGLVHIWQAGSFPITPERLPGWGGKTVLQAALGVKHGVLLTEDGEVYS 64

Query: 348 Y 346
           +
Sbjct: 65  F 65

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>NEK8_BRARE (Q90XC2) Serine/threonine-protein kinase Nek8 (EC 2.7.11.1)|
           (NimA-related protein kinase 8)
          Length = 697

 Score = 73.9 bits (180), Expect = 5e-13
 Identities = 42/127 (33%), Positives = 68/127 (53%)
 Frame = -3

Query: 729 VSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGG 550
           +  ++ G      L+   I+  +G+   G LG G+    +QP  VE L    LV ++ G 
Sbjct: 400 IKSVSCGDLFTTCLTDRGIIMTFGSGSNGCLGHGNFNDVTQPKIVEALLGYELVQVSCGA 459

Query: 549 WHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLT 370
            H  A+T E EV++WGRG++GRLG    + SH  P QV L A  +  +V CG   S++++
Sbjct: 460 SHVLAVTNEREVFSWGRGDNGRLGLA-TQDSHNCPQQVSLPADFEAQRVLCGVDCSMIMS 518

Query: 369 SDGRIFS 349
           +  +I +
Sbjct: 519 TQHQILA 525



 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 34/113 (30%), Positives = 60/113 (53%)
 Frame = -3

Query: 735 EQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAA 556
           E++  I +G  H++A++     + +G+N++GQLG    +    P +V GL  +++   A 
Sbjct: 568 EKIVYIDIGTAHSVAVTEKGQCFTFGSNQHGQLGCSHRRSSRVPYQVSGLQGITMA--AC 625

Query: 555 GGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSC 397
           G   + A+  EGEVY WG+G  GRLG  ++      P+Q+       +  V+C
Sbjct: 626 GDAFTLAIGAEGEVYTWGKGARGRLGRKEEDFGIPKPVQLDESHAFTVTSVAC 678



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 36/135 (26%), Positives = 67/135 (49%), Gaps = 6/135 (4%)
 Frame = -3

Query: 732 QVSMIAVGAFHNLALSVDRILWAW-----GNNEYGQLG-IGDTQPRSQPIRVEGLSNLSL 571
           +V  +++G    + ++    L  W     G+ E    G +   QP+     +EG S +++
Sbjct: 341 EVIQVSLGRTQKMGVTKSGRLITWEAPSVGSGEPTLPGAVEQMQPQFISRFLEGQSGVTI 400

Query: 570 VDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGG 391
             ++ G   +  LT  G +  +G G +G LG G+       P  V+ L G ++VQVSCG 
Sbjct: 401 KSVSCGDLFTTCLTDRGIIMTFGSGSNGCLGHGNFNDVTQ-PKIVEALLGYELVQVSCGA 459

Query: 390 THSVVLTSDGRIFSY 346
           +H + +T++  +FS+
Sbjct: 460 SHVLAVTNEREVFSW 474



 Score = 53.1 bits (126), Expect = 9e-07
 Identities = 46/196 (23%), Positives = 82/196 (41%), Gaps = 13/196 (6%)
 Frame = -3

Query: 732 QVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAG 553
           ++  ++ GA H LA++ +R +++WG  + G+LG+      + P +V   ++     +  G
Sbjct: 451 ELVQVSCGASHVLAVTNEREVFSWGRGDNGRLGLATQDSHNCPQQVSLPADFEAQRVLCG 510

Query: 552 GWHSAALTKEGEVYAWGRGEHGRLGF----GDDKSS--------HMVPL-QVQLLAGEDI 412
              S  ++ + ++ A G     +LG     G ++ S        H+  L Q   L  E I
Sbjct: 511 VDCSMIMSTQHQILACGNNRFNKLGLDKVSGTEEPSSFCQVEEVHLFQLVQSAPLNTEKI 570

Query: 411 VQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSSEGL 232
           V +  G  HSV +T  G+ F++            + ++  P +V              GL
Sbjct: 571 VYIDIGTAHSVAVTEKGQCFTFGSNQHGQLGCSHRRSSRVPYQV-------------SGL 617

Query: 231 WQANYVACGGRHTLAI 184
                 ACG   TLAI
Sbjct: 618 QGITMAACGDAFTLAI 633



 Score = 30.8 bits (68), Expect = 4.7
 Identities = 13/39 (33%), Positives = 22/39 (56%)
 Frame = -3

Query: 750 RVQGLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLG 634
           +V GL+ ++M A G    LA+  +  ++ WG    G+LG
Sbjct: 613 QVSGLQGITMAACGDAFTLAIGAEGEVYTWGKGARGRLG 651

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>NEK9_XENLA (Q7ZZC8) Serine/threonine-protein kinase Nek9 (EC 2.7.11.1)|
           (NimA-related protein kinase 9) (XNek9) (Nercc1 kinase)
          Length = 944

 Score = 73.6 bits (179), Expect = 6e-13
 Identities = 41/131 (31%), Positives = 67/131 (51%), Gaps = 6/131 (4%)
 Frame = -3

Query: 720 IAVGAFHNLALSVDRILWAW-----GNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAA 556
           +  G  H   ++V++ L+ W     G+  +GQLG GD     QP  VE L   S+  ++ 
Sbjct: 356 VCAGDAHFAVVTVEKELYTWVNMQGGSKLHGQLGHGDRASYRQPKHVEKLQGKSVQKVSC 415

Query: 555 GGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMV-PLQVQLLAGEDIVQVSCGGTHSV 379
           G   +  +T EG++Y++G   +G LG      S ++ PL V     E + QVSCG +H +
Sbjct: 416 GSDFTVCITDEGQLYSFGSDYYGCLGVNQSAGSEVLEPLLVDFFLNEPVDQVSCGDSHIM 475

Query: 378 VLTSDGRIFSY 346
            LT    ++S+
Sbjct: 476 ALTRSKSVYSW 486



 Score = 69.7 bits (169), Expect = 9e-12
 Identities = 41/136 (30%), Positives = 75/136 (55%), Gaps = 2/136 (1%)
 Frame = -3

Query: 750 RVQGLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRS--QPIRVEGLSNL 577
           ++QG + V  ++ G+   + ++ +  L+++G++ YG LG+  +      +P+ V+   N 
Sbjct: 404 KLQG-KSVQKVSCGSDFTVCITDEGQLYSFGSDYYGCLGVNQSAGSEVLEPLLVDFFLNE 462

Query: 576 SLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSC 397
            +  ++ G  H  ALT+   VY+WG GE+GRLG  D +     P +V++  G  IV V C
Sbjct: 463 PVDQVSCGDSHIMALTRSKSVYSWGCGEYGRLGL-DSEDDVYSPQKVEVQRGLCIVNVCC 521

Query: 396 GGTHSVVLTSDGRIFS 349
           G   S +LT  G++ +
Sbjct: 522 GSDGSFLLTLTGKVLA 537



 Score = 63.2 bits (152), Expect = 9e-10
 Identities = 41/142 (28%), Positives = 67/142 (47%), Gaps = 12/142 (8%)
 Frame = -3

Query: 735 EQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAA 556
           E V  ++ G  H +AL+  + +++WG  EYG+LG+        P +VE    L +V++  
Sbjct: 462 EPVDQVSCGDSHIMALTRSKSVYSWGCGEYGRLGLDSEDDVYSPQKVEVQRGLCIVNVCC 521

Query: 555 GGWHSAALTKEGEVYAWGRGEHGRLGFG-------DDKSSHMVPLQVQL-----LAGEDI 412
           G   S  LT  G+V A G  EH +LG         + ++   VP    L     L+   I
Sbjct: 522 GSDGSFLLTLTGKVLACGLNEHNKLGLNQYTAGIINHEAFQEVPYTTSLTLAKQLSFYKI 581

Query: 411 VQVSCGGTHSVVLTSDGRIFSY 346
             +S G TH+  +   GR+ ++
Sbjct: 582 RSISPGRTHTAAIDERGRLLTF 603



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 34/138 (24%), Positives = 66/138 (47%), Gaps = 13/138 (9%)
 Frame = -3

Query: 720 IAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQ------------PRSQPIRV-EGLSN 580
           +  G+  +  L++   + A G NE+ +LG+                P +  + + + LS 
Sbjct: 519 VCCGSDGSFLLTLTGKVLACGLNEHNKLGLNQYTAGIINHEAFQEVPYTTSLTLAKQLSF 578

Query: 579 LSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVS 400
             +  I+ G  H+AA+ + G +  +G  + G+LG GD +    + L    L G+ +++VS
Sbjct: 579 YKIRSISPGRTHTAAIDERGRLLTFGSNKCGQLGVGDYRKHLGINLLGGPLGGKQVIRVS 638

Query: 399 CGGTHSVVLTSDGRIFSY 346
           CG   +   T+D  IF++
Sbjct: 639 CGDEFTTAATADNHIFAW 656



 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 33/129 (25%), Positives = 60/129 (46%), Gaps = 9/129 (6%)
 Frame = -3

Query: 732 QVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEG-LSNLSLVDIAA 556
           ++  I+ G  H  A+     L  +G+N+ GQLG+GD +       + G L    ++ ++ 
Sbjct: 580 KIRSISPGRTHTAAIDERGRLLTFGSNKCGQLGVGDYRKHLGINLLGGPLGGKQVIRVSC 639

Query: 555 GGWHSAALTKEGEVYAWGRGEHGRLGF--------GDDKSSHMVPLQVQLLAGEDIVQVS 400
           G   + A T +  ++AWG G +GRL           D  +S   P+   L     +  +S
Sbjct: 640 GDEFTTAATADNHIFAWGNGGNGRLAMTPNERPQGSDICTSWPRPIFGSL---HHVTDLS 696

Query: 399 CGGTHSVVL 373
           C G H++++
Sbjct: 697 CRGWHTILI 705



 Score = 30.4 bits (67), Expect = 6.1
 Identities = 21/80 (26%), Positives = 37/80 (46%), Gaps = 7/80 (8%)
 Frame = -3

Query: 741 GLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGI-------GDTQPRSQPIRVEGLS 583
           G +QV  ++ G     A + D  ++AWGN   G+L +       G     S P  + G S
Sbjct: 630 GGKQVIRVSCGDEFTTAATADNHIFAWGNGGNGRLAMTPNERPQGSDICTSWPRPIFG-S 688

Query: 582 NLSLVDIAAGGWHSAALTKE 523
              + D++  GWH+  + ++
Sbjct: 689 LHHVTDLSCRGWHTILIVEK 708

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>GNEFR_MOUSE (Q80YD6) Guanine nucleotide exchange factor-related protein|
           (Deafness locus associated putative guanine nucleotide
           exchange factor) (DelGEF)
          Length = 464

 Score = 73.2 bits (178), Expect = 8e-13
 Identities = 58/201 (28%), Positives = 88/201 (43%), Gaps = 16/201 (7%)
 Frame = -3

Query: 735 EQVSMIAVGAFHNLALSVDRILWAWGN---NEYGQLGIGDTQP----RSQPIRVEGLSNL 577
           E+V  +A G  H LA +    ++ WG    +   +L  G   P      +P RV GL N 
Sbjct: 153 EKVVCVAAGLRHALATTATGSVFQWGTGLASSGRRLCPGQNLPLFLTAKEPSRVTGLENS 212

Query: 576 SLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLA----GEDIV 409
           + V   AG  HSA+LT  GE+Y WGR +HG+L       +  +PL  ++ A     E + 
Sbjct: 213 TAVCAVAGSDHSASLTDTGELYVWGRNKHGQLA----SRAVFLPLPQRIEAHYFQDEKVT 268

Query: 408 QVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXRKVTTGH-PMEVPINL----PPPKTSTS 244
            V  G TH V  T  G++F++            +      P+E   +L    P     + 
Sbjct: 269 AVWSGWTHLVAKTETGKVFTWGRADYGQLGRRLEPPEAQKPVEQDSSLAFQGPQNSVPSP 328

Query: 243 SEGLWQANYVACGGRHTLAIV 181
              L  A  ++CG  H LA++
Sbjct: 329 LHCLTGATEISCGSEHNLAVI 349



 Score = 64.7 bits (156), Expect = 3e-10
 Identities = 36/115 (31%), Positives = 60/115 (52%), Gaps = 1/115 (0%)
 Frame = -3

Query: 690 LSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLV-DIAAGGWHSAALTKEGEV 514
           +S   +L+AWG N YGQLG+G  +    P ++        +  +  GG HSA +T  G++
Sbjct: 11  VSAAAVLFAWGANSYGQLGLGHKEDVFLPQQLSDFCQAGCIKSVTGGGGHSAVVTDGGDL 70

Query: 513 YAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFS 349
           +  G  + G+LG G  +      +  + L G  I QV+CG   +++LT  G++ S
Sbjct: 71  FVCGLNKDGQLGLGHTEEVLRFTI-CKPLRGCPIRQVACGWDFTIMLTEKGQVLS 124



 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 33/128 (25%), Positives = 62/128 (48%)
 Frame = -3

Query: 729 VSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGG 550
           +  +  G  H+  ++    L+  G N+ GQLG+G T+   +    + L    +  +A G 
Sbjct: 51  IKSVTGGGGHSAVVTDGGDLFVCGLNKDGQLGLGHTEEVLRFTICKPLRGCPIRQVACGW 110

Query: 549 WHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLT 370
             +  LT++G+V + G    G+LG        +VP  ++ L  E +V V+ G  H++  T
Sbjct: 111 DFTIMLTEKGQVLSCGSNAFGQLGVPHGPRKCVVPQAIECLR-EKVVCVAAGLRHALATT 169

Query: 369 SDGRIFSY 346
           + G +F +
Sbjct: 170 ATGSVFQW 177



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 39/140 (27%), Positives = 65/140 (46%), Gaps = 19/140 (13%)
 Frame = -3

Query: 735 EQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSL----- 571
           E+V+ +  G  H +A +    ++ WG  +YGQLG     P +Q   VE  S+L+      
Sbjct: 265 EKVTAVWSGWTHLVAKTETGKVFTWGRADYGQLGRRLEPPEAQK-PVEQDSSLAFQGPQN 323

Query: 570 ------------VDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLL 427
                        +I+ G  H+ A+ ++ +  +WG  EHG  G G + S+   P  VQ L
Sbjct: 324 SVPSPLHCLTGATEISCGSEHNLAVIRD-KCCSWGWNEHGMCGDGTE-SNVWTPTPVQAL 381

Query: 426 --AGEDIVQVSCGGTHSVVL 373
             +   ++ V CG  HS+ +
Sbjct: 382 PPSPSRLLLVGCGAGHSLAV 401



 Score = 35.4 bits (80), Expect = 0.19
 Identities = 22/70 (31%), Positives = 32/70 (45%), Gaps = 6/70 (8%)
 Frame = -3

Query: 543 SAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSC------GGTHS 382
           S  ++    ++AWG   +G+LG G  K    +P Q+      D  Q  C      GG HS
Sbjct: 8   SETVSAAAVLFAWGANSYGQLGLG-HKEDVFLPQQL-----SDFCQAGCIKSVTGGGGHS 61

Query: 381 VVLTSDGRIF 352
            V+T  G +F
Sbjct: 62  AVVTDGGDLF 71

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>RCC1_SCHPO (P28745) Protein pim1 (Poly(A)+ RNA transport protein 2)|
          Length = 539

 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 52/205 (25%), Positives = 89/205 (43%), Gaps = 18/205 (8%)
 Frame = -3

Query: 738 LEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRS-QPIRVEGLSNLSLVDI 562
           L ++  +A G  H +AL+    ++ WGN +  QLG    + R  Q +  + L+  +++ +
Sbjct: 225 LPEICQLATGTDHIIALTTTGKVYTWGNGQQFQLGRRMLERRRLQGLTPQPLALKNIISV 284

Query: 561 AAGGWHSAALTKEGEVYAWGRGEHGRLGF--GDDKSSHMV--PLQVQLLAGEDIVQVSCG 394
            AG +HS A+  +G VYAWG     + G    D++   ++  P  V  L G ++  ++ G
Sbjct: 285 GAGSYHSFAIDNKGRVYAWGLNITRQCGIEVEDEEEGAVITKPTLVDALEGYNVKSITGG 344

Query: 393 GTHSVVLTSDGRIFSYXXXXXXXXXXXRKVTTGHPMEVPINLPPP-------------KT 253
             H++ L  DGR+ ++                 H + +P N  P               T
Sbjct: 345 EHHTLALLEDGRVLAWGRDDR------------HQLGIPDNALPETVVKDEKGNNYYLST 392

Query: 252 STSSEGLWQANYVACGGRHTLAIVT 178
            T   GL     V CG  H LA+ +
Sbjct: 393 PTIIPGLTNVIQVVCGTHHNLAVTS 417



 Score = 68.9 bits (167), Expect = 2e-11
 Identities = 40/147 (27%), Positives = 74/147 (50%), Gaps = 16/147 (10%)
 Frame = -3

Query: 738 LEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPR-----SQPIRVEGLSNLS 574
           L+ +  +  G++H+ A+     ++AWG N   Q GI           ++P  V+ L   +
Sbjct: 278 LKNIISVGAGSYHSFAIDNKGRVYAWGLNITRQCGIEVEDEEEGAVITKPTLVDALEGYN 337

Query: 573 LVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGD----------DKSSHMVPLQVQLLA 424
           +  I  G  H+ AL ++G V AWGR +  +LG  D          +K ++       ++ 
Sbjct: 338 VKSITGGEHHTLALLEDGRVLAWGRDDRHQLGIPDNALPETVVKDEKGNNYYLSTPTIIP 397

Query: 423 G-EDIVQVSCGGTHSVVLTSDGRIFSY 346
           G  +++QV CG  H++ +TSDG+++S+
Sbjct: 398 GLTNVIQVVCGTHHNLAVTSDGKVYSW 424



 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 41/134 (30%), Positives = 64/134 (47%), Gaps = 16/134 (11%)
 Frame = -3

Query: 729 VSMIAVGAFHNLALSVDRILWAWGNNEYGQLGI--------------GDTQPRSQPIRVE 592
           V  I  G  H LAL  D  + AWG ++  QLGI              G+    S P  + 
Sbjct: 338 VKSITGGEHHTLALLEDGRVLAWGRDDRHQLGIPDNALPETVVKDEKGNNYYLSTPTIIP 397

Query: 591 GLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDI 412
           GL+N+  + +  G  H+ A+T +G+VY+WG  E+  +G GD+     VP  V+  A +++
Sbjct: 398 GLTNV--IQVVCGTHHNLAVTSDGKVYSWGSAENYEVGQGDNDEDVAVPTLVRSKAIKEV 455

Query: 411 V--QVSCGGTHSVV 376
                  GG  S++
Sbjct: 456 AIRVAGAGGQFSII 469



 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 41/141 (29%), Positives = 69/141 (48%), Gaps = 16/141 (11%)
 Frame = -3

Query: 720 IAVGAFHNLALSVDRILWAWGNNEYGQLG-------------IGDTQPRSQPIRVEG-LS 583
           +AVG  H+ ALS D  ++ WG N+   LG             + +      P +VEG LS
Sbjct: 113 LAVGGMHSAALSHDGRVYTWGVNDDYALGRLTKDQKDENGDKVDNDLLEGTPSKVEGALS 172

Query: 582 NLSLVDIAAGGWHSAALTKEGEVYAWG--RGEHGRLGFGDDKSSHMVPLQVQLLAGEDIV 409
           +L +  +      +AA+T  G  + WG  R   G LG+ D +     P Q++L    +I 
Sbjct: 173 HLRVTKVICSDNLTAAITDNGCCFTWGTFRCSDGVLGYSDSQKRTAEPTQMRL---PEIC 229

Query: 408 QVSCGGTHSVVLTSDGRIFSY 346
           Q++ G  H + LT+ G+++++
Sbjct: 230 QLATGTDHIIALTTTGKVYTW 250



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 35/118 (29%), Positives = 57/118 (48%), Gaps = 2/118 (1%)
 Frame = -3

Query: 693 ALSVDRILWAWGNNEY--GQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEG 520
           A++ +   + WG      G LG  D+Q R+       L  +    +A G  H  ALT  G
Sbjct: 188 AITDNGCCFTWGTFRCSDGVLGYSDSQKRTAEPTQMRLPEIC--QLATGTDHIIALTTTG 245

Query: 519 EVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSY 346
           +VY WG G+  +LG    +   +  L  Q LA ++I+ V  G  HS  + + GR++++
Sbjct: 246 KVYTWGNGQQFQLGRRMLERRRLQGLTPQPLALKNIISVGAGSYHSFAIDNKGRVYAW 303



 Score = 50.4 bits (119), Expect = 6e-06
 Identities = 35/128 (27%), Positives = 58/128 (45%), Gaps = 19/128 (14%)
 Frame = -3

Query: 672 LWAWGNNEYGQLGIGDTQ------PRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVY 511
           ++ +G+    +LG+G+ +      PR  PI       + +VD+A GG HSAAL+ +G VY
Sbjct: 73  VYVFGSGSMNELGMGEEEMDVVYRPRLNPIL--STDKVGVVDLAVGGMHSAALSHDGRVY 130

Query: 510 AWGRGEHGRLG--FGDDKSSHMVPLQVQLLAGED-----------IVQVSCGGTHSVVLT 370
            WG  +   LG    D K  +   +   LL G             + +V C    +  +T
Sbjct: 131 TWGVNDDYALGRLTKDQKDENGDKVDNDLLEGTPSKVEGALSHLRVTKVICSDNLTAAIT 190

Query: 369 SDGRIFSY 346
            +G  F++
Sbjct: 191 DNGCCFTW 198



 Score = 36.6 bits (83), Expect = 0.085
 Identities = 21/72 (29%), Positives = 39/72 (54%), Gaps = 3/72 (4%)
 Frame = -3

Query: 747 VQGLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDT-QPRSQP--IRVEGLSNL 577
           + GL  V  +  G  HNLA++ D  +++WG+ E  ++G GD  +  + P  +R + +  +
Sbjct: 396 IPGLTNVIQVVCGTHHNLAVTSDGKVYSWGSAENYEVGQGDNDEDVAVPTLVRSKAIKEV 455

Query: 576 SLVDIAAGGWHS 541
           ++    AGG  S
Sbjct: 456 AIRVAGAGGQFS 467

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>ALS2_MOUSE (Q920R0) Alsin (Amyotrophic lateral sclerosis protein 2 homolog)|
          Length = 1651

 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 36/100 (36%), Positives = 57/100 (57%)
 Frame = -3

Query: 672 LWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGE 493
           +W WG  + GQLG GD  PR QP+ V+ L    ++ + AGG HS ALT + +VY+WG   
Sbjct: 522 VWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGSHSLALTAKSQVYSWGSNT 581

Query: 492 HGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVL 373
            G+LG  +  ++  VP   ++ +   +  V+ G  +S+ L
Sbjct: 582 FGQLGHSEFPTT--VPRLSKVSSENGVWSVAAGQDYSLFL 619



 Score = 60.5 bits (145), Expect = 6e-09
 Identities = 37/122 (30%), Positives = 62/122 (50%)
 Frame = -3

Query: 519 EVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSYXX 340
           EV+ WG+G+ G+LG GD     + PL V+ L G++++ +  GG+HS+ LT+  +++S+  
Sbjct: 521 EVWTWGKGKEGQLGHGD-VLPRLQPLCVKCLDGKEVIHLEAGGSHSLALTAKSQVYSWGS 579

Query: 339 XXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGRHTLAIVTWTDM*L 160
                         GH  E P  +P     +S  G+W    VA G  ++L +V   D   
Sbjct: 580 NTFG--------QLGH-SEFPTTVPRLSKVSSENGVWS---VAAGQDYSLFLVDTEDFQP 627

Query: 159 GI 154
           G+
Sbjct: 628 GL 629



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 47/194 (24%), Positives = 83/194 (42%), Gaps = 7/194 (3%)
 Frame = -3

Query: 741 GLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDI 562
           G + V   A+G  H + L+ D  ++++G   +      +  P S P+    L    ++ +
Sbjct: 39  GGKTVLQAALGVRHGVLLTEDGEVYSFGTLPWKSES-AEICP-SSPLLESALVGHHVITV 96

Query: 561 AAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGED-------IVQV 403
           A G +HS A+T+ G VY WG    G+    + +     P  V +   E        I+Q+
Sbjct: 97  ATGSFHSGAVTESGVVYMWGENAAGQCAVANQQYV-PEPSPVSISDSETSPSLAVRILQL 155

Query: 402 SCGGTHSVVLTSDGRIFSYXXXXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSSEGLWQA 223
           +CG  H++ L+    I+++             +TT      P+  P      +   + Q 
Sbjct: 156 ACGEEHTLALSLSREIWAWGTGCQLGL-----ITT----TFPVTKPQKVEHLAGRVVLQ- 205

Query: 222 NYVACGGRHTLAIV 181
             VACG  H+LA+V
Sbjct: 206 --VACGAFHSLALV 217



 Score = 46.6 bits (109), Expect = 8e-05
 Identities = 43/164 (26%), Positives = 66/164 (40%), Gaps = 11/164 (6%)
 Frame = -3

Query: 606 PIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWG----RGEHGRLGFGDDKSSHMVPLQ 439
           P R+ G    +++  A G  H   LT++GEVY++G    + E   +           PL 
Sbjct: 32  PERLPGWGGKTVLQAALGVRHGVLLTEDGEVYSFGTLPWKSESAEI-------CPSSPLL 84

Query: 438 VQLLAGEDIVQVSCGGTHSVVLTSDGRIFSYXXXXXXXXXXXRKVTTGHPMEVPINLPPP 259
              L G  ++ V+ G  HS  +T  G ++ +            +     P  V I+    
Sbjct: 85  ESALVGHHVITVATGSFHSGAVTESGVVYMWGENAAGQCAVANQQYVPEPSPVSIS---- 140

Query: 258 KTSTSSEGLWQANYVACGGRHTLA------IVTW-TDM*LGIIT 148
            + TS     +   +ACG  HTLA      I  W T   LG+IT
Sbjct: 141 DSETSPSLAVRILQLACGEEHTLALSLSREIWAWGTGCQLGLIT 184



 Score = 35.0 bits (79), Expect = 0.25
 Identities = 22/67 (32%), Positives = 34/67 (50%)
 Frame = -3

Query: 735 EQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAA 556
           ++V  +  G  H+LAL+    +++WG+N +GQLG  +  P + P        LS V    
Sbjct: 553 KEVIHLEAGGSHSLALTAKSQVYSWGSNTFGQLGHSEF-PTTVP-------RLSKVSSEN 604

Query: 555 GGWHSAA 535
           G W  AA
Sbjct: 605 GVWSVAA 611



 Score = 33.5 bits (75), Expect = 0.72
 Identities = 17/61 (27%), Positives = 30/61 (49%)
 Frame = -3

Query: 528 KEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFS 349
           K+    A G  E G +      S  + P ++    G+ ++Q + G  H V+LT DG ++S
Sbjct: 5   KKSSTEAEGSKERGLVHVWQAGSFSLTPERLPGWGGKTVLQAALGVRHGVLLTEDGEVYS 64

Query: 348 Y 346
           +
Sbjct: 65  F 65

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>RCC1_MESAU (P23800) Regulator of chromosome condensation (Chromosome|
           condensation protein 1)
          Length = 421

 Score = 70.9 bits (172), Expect = 4e-12
 Identities = 48/148 (32%), Positives = 79/148 (53%), Gaps = 5/148 (3%)
 Frame = -3

Query: 660 GNNEYGQLGIGDTQ-PRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGR 484
           G  + GQLG+G++   R +P  V  L ++  V   AGG H+  L + G+VY++G  + G 
Sbjct: 41  GQGDVGQLGLGESVLERKKPALVPLLQDV--VQAEAGGMHTVCLNQSGQVYSFGCNDEGA 98

Query: 483 LGFGDD-KSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIF---SYXXXXXXXXXX 316
           LG     + S MVP +V+L   E +VQVS G +H+  LT DGR+F   S+          
Sbjct: 99  LGRDTSVEGSEMVPGKVELQ--EKVVQVSAGDSHTAALTEDGRVFLWGSFRDNNGVIGLL 156

Query: 315 XRKVTTGHPMEVPINLPPPKTSTSSEGL 232
                +  P++V +++P  K ++ ++ L
Sbjct: 157 EPMKKSMVPVQVQLDMPVVKVASGNDHL 184



 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 46/179 (25%), Positives = 78/179 (43%), Gaps = 2/179 (1%)
 Frame = -3

Query: 711 GAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNL--SLVDIAAGGWHSA 538
           GA+   A+S +  ++ +G + Y QLG   T     P  +    N   S V  + G  H+ 
Sbjct: 248 GAYLTFAISREGHVYGFGLSNYHQLGTPGTASCFIPQNLTSFKNSTKSWVGFSGGQHHTI 307

Query: 537 ALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGR 358
            +  EG+ Y+ GR E+GRLG G+      +P  +  L    +  V+CG +    ++ DGR
Sbjct: 308 CMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRL--PVVSSVACGASVGYAVSKDGR 365

Query: 357 IFSYXXXXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGRHTLAIV 181
           +F++           +      P+E+        T    E       V+ GG+HT+ +V
Sbjct: 366 VFAWGMGTNYQLGTGQDEDAWSPVEM--------TGKQLENRVVLT-VSSGGQHTVLLV 415



 Score = 47.8 bits (112), Expect = 4e-05
 Identities = 24/67 (35%), Positives = 37/67 (55%)
 Frame = -3

Query: 546 HSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTS 367
           H +  T+ G V   G+G+ G+LG G+       P  V LL  +D+VQ   GG H+V L  
Sbjct: 27  HRSHKTEPGLVLTLGQGDVGQLGLGESVLERKKPALVPLL--QDVVQAEAGGMHTVCLNQ 84

Query: 366 DGRIFSY 346
            G+++S+
Sbjct: 85  SGQVYSF 91



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 26/79 (32%), Positives = 41/79 (51%), Gaps = 2/79 (2%)
 Frame = -3

Query: 747 VQGLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEG--LSNLS 574
           +  L  VS +A GA    A+S D  ++AWG     QLG G  +    P+ + G  L N  
Sbjct: 341 ISRLPVVSSVACGASVGYAVSKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMTGKQLENRV 400

Query: 573 LVDIAAGGWHSAALTKEGE 517
           ++ +++GG H+  L K+ E
Sbjct: 401 VLTVSSGGQHTVLLVKDKE 419

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>NEK9_MOUSE (Q8K1R7) Serine/threonine-protein kinase Nek9 (EC 2.7.11.1)|
           (NimA-related protein kinase 9) (Never in mitosis
           A-related kinase 9)
          Length = 984

 Score = 70.9 bits (172), Expect = 4e-12
 Identities = 42/133 (31%), Positives = 69/133 (51%), Gaps = 8/133 (6%)
 Frame = -3

Query: 720 IAVGAFHNLALSVDRILWAWGNNE-----YGQLGIGDTQPRSQPIRVEGLSNLSLVDIAA 556
           +  G  H   ++V++ L+ W N +     +GQLG GD     QP  VE L   ++  ++ 
Sbjct: 374 VCAGNTHFAVVTVEKELYTWVNMQGGTKLHGQLGHGDKASYRQPKHVEKLQGKAIHQVSC 433

Query: 555 GGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSH---MVPLQVQLLAGEDIVQVSCGGTH 385
           G   +  +T EG++YA+G   +G +G   DK S    + P+Q+       + QVSCG  H
Sbjct: 434 GDDFTVCVTDEGQLYAFGSDYYGCMGV--DKVSGPEVLEPMQLNFFLSNPVEQVSCGDNH 491

Query: 384 SVVLTSDGRIFSY 346
            VVLT +  ++S+
Sbjct: 492 VVVLTRNKEVYSW 504



 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 36/136 (26%), Positives = 72/136 (52%), Gaps = 2/136 (1%)
 Frame = -3

Query: 750 RVQGLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRS--QPIRVEGLSNL 577
           ++QG + +  ++ G    + ++ +  L+A+G++ YG +G+         +P+++    + 
Sbjct: 422 KLQG-KAIHQVSCGDDFTVCVTDEGQLYAFGSDYYGCMGVDKVSGPEVLEPMQLNFFLSN 480

Query: 576 SLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSC 397
            +  ++ G  H   LT+  EVY+WG GE+GRLG  D +  +  P +V +     IV V C
Sbjct: 481 PVEQVSCGDNHVVVLTRNKEVYSWGCGEYGRLGL-DSEEDYYTPQRVDVPKALIIVAVQC 539

Query: 396 GGTHSVVLTSDGRIFS 349
           G   + +LT  G++ +
Sbjct: 540 GCDGTFLLTQSGKVLA 555



 Score = 53.1 bits (126), Expect = 9e-07
 Identities = 36/140 (25%), Positives = 66/140 (47%), Gaps = 12/140 (8%)
 Frame = -3

Query: 729 VSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGG 550
           V  ++ G  H + L+ ++ +++WG  EYG+LG+   +    P RV+    L +V +  G 
Sbjct: 482 VEQVSCGDNHVVVLTRNKEVYSWGCGEYGRLGLDSEEDYYTPQRVDVPKALIIVAVQCGC 541

Query: 549 WHSAALTKEGEVYAWGRGEHGRLGFG-------DDKSSHMVPLQVQL-----LAGEDIVQ 406
             +  LT+ G+V A G  E  +LG         + ++ H VP          L+   I  
Sbjct: 542 DGTFLLTQSGKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIRT 601

Query: 405 VSCGGTHSVVLTSDGRIFSY 346
           ++ G TH+  +   GR+ ++
Sbjct: 602 IAPGKTHTAAIDERGRLLTF 621



 Score = 47.0 bits (110), Expect = 6e-05
 Identities = 31/126 (24%), Positives = 58/126 (46%), Gaps = 6/126 (4%)
 Frame = -3

Query: 732 QVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEG-LSNLSLVDIAA 556
           ++  IA G  H  A+     L  +G N+ GQLG+G+ + R     + G L    ++ ++ 
Sbjct: 598 KIRTIAPGKTHTAAIDERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRVSC 657

Query: 555 GGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQ-----LLAGEDIVQVSCGG 391
           G   + A T +  ++AWG G +GRL     +  H   +          +   +  +SC G
Sbjct: 658 GDEFTIAATDDNHIFAWGNGGNGRLAMTPTERPHGSDICTSWPRPIFGSLHHVPDLSCRG 717

Query: 390 THSVVL 373
            H++++
Sbjct: 718 WHTILI 723



 Score = 30.8 bits (68), Expect = 4.7
 Identities = 21/80 (26%), Positives = 39/80 (48%), Gaps = 7/80 (8%)
 Frame = -3

Query: 741 GLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQP-------RSQPIRVEGLS 583
           G +QV  ++ G    +A + D  ++AWGN   G+L +  T+         S P  + G S
Sbjct: 648 GGKQVIRVSCGDEFTIAATDDNHIFAWGNGGNGRLAMTPTERPHGSDICTSWPRPIFG-S 706

Query: 582 NLSLVDIAAGGWHSAALTKE 523
              + D++  GWH+  + ++
Sbjct: 707 LHHVPDLSCRGWHTILIVEK 726

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>RCC1_HUMAN (P18754) Regulator of chromosome condensation (Chromosome|
           condensation protein 1) (Cell cycle regulatory protein)
          Length = 421

 Score = 70.5 bits (171), Expect = 5e-12
 Identities = 48/148 (32%), Positives = 78/148 (52%), Gaps = 5/148 (3%)
 Frame = -3

Query: 660 GNNEYGQLGIGDT-QPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGR 484
           G  + GQLG+G+    R +P  V    ++  V   AGG H+  L+K G+VY++G  + G 
Sbjct: 41  GQGDVGQLGLGENVMERKKPALVSIPEDV--VQAEAGGMHTVCLSKSGQVYSFGCNDEGA 98

Query: 483 LGFGDD-KSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIF---SYXXXXXXXXXX 316
           LG     + S MVP +V+L   E +VQVS G +H+  LT DGR+F   S+          
Sbjct: 99  LGRDTSVEGSEMVPGKVEL--QEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLL 156

Query: 315 XRKVTTGHPMEVPINLPPPKTSTSSEGL 232
                +  P++V +++P  K ++ ++ L
Sbjct: 157 EPMKKSMVPVQVQLDVPVVKVASGNDHL 184



 Score = 68.2 bits (165), Expect = 3e-11
 Identities = 46/179 (25%), Positives = 79/179 (44%), Gaps = 2/179 (1%)
 Frame = -3

Query: 711 GAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNL--SLVDIAAGGWHSA 538
           GA+   A+S +  ++ +G + Y QLG   T+    P  +    N   S V  + G  H+ 
Sbjct: 248 GAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTV 307

Query: 537 ALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGR 358
            +  EG+ Y+ GR E+GRLG G+      +P  +  L    +  V+CG +    +T DGR
Sbjct: 308 CMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPA--VSSVACGASVGYAVTKDGR 365

Query: 357 IFSYXXXXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGRHTLAIV 181
           +F++           +      P+E+       +   S         V+ GG+HT+ +V
Sbjct: 366 VFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLS---------VSSGGQHTVLLV 415



 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 23/67 (34%), Positives = 38/67 (56%)
 Frame = -3

Query: 546 HSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTS 367
           H +  T+ G V   G+G+ G+LG G++      P  V +   ED+VQ   GG H+V L+ 
Sbjct: 27  HRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSI--PEDVVQAEAGGMHTVCLSK 84

Query: 366 DGRIFSY 346
            G+++S+
Sbjct: 85  SGQVYSF 91



 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 25/79 (31%), Positives = 41/79 (51%), Gaps = 2/79 (2%)
 Frame = -3

Query: 747 VQGLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEG--LSNLS 574
           +  L  VS +A GA    A++ D  ++AWG     QLG G  +    P+ + G  L N  
Sbjct: 341 ISRLPAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRV 400

Query: 573 LVDIAAGGWHSAALTKEGE 517
           ++ +++GG H+  L K+ E
Sbjct: 401 VLSVSSGGQHTVLLVKDKE 419

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>NEK9_HUMAN (Q8TD19) Serine/threonine-protein kinase Nek9 (EC 2.7.11.1)|
           (NimA-related protein kinase 9) (Never in mitosis
           A-related kinase 9) (Nercc1 kinase) (NIMA-related kinase
           8) (Nek8)
          Length = 979

 Score = 70.5 bits (171), Expect = 5e-12
 Identities = 39/131 (29%), Positives = 67/131 (51%), Gaps = 6/131 (4%)
 Frame = -3

Query: 720 IAVGAFHNLALSVDRILWAWGNNE-----YGQLGIGDTQPRSQPIRVEGLSNLSLVDIAA 556
           +  G  H   ++V++ L+ W N +     +GQLG GD     QP  VE L   ++  ++ 
Sbjct: 374 VCAGNTHFAVVTVEKELYTWVNMQGGTKLHGQLGHGDKASYRQPKHVEKLQGKAIHQVSC 433

Query: 555 GGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMV-PLQVQLLAGEDIVQVSCGGTHSV 379
           G   +  +T EG++YA+G   +G +G        ++ P+Q+       + QVSCG  H V
Sbjct: 434 GDDFTVCVTDEGQLYAFGSDYYGCMGVDKVAGPEVLEPMQLNFFLSNPVEQVSCGDNHVV 493

Query: 378 VLTSDGRIFSY 346
           VLT +  ++S+
Sbjct: 494 VLTRNKEVYSW 504



 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 36/136 (26%), Positives = 72/136 (52%), Gaps = 2/136 (1%)
 Frame = -3

Query: 750 RVQGLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRS--QPIRVEGLSNL 577
           ++QG + +  ++ G    + ++ +  L+A+G++ YG +G+         +P+++    + 
Sbjct: 422 KLQG-KAIHQVSCGDDFTVCVTDEGQLYAFGSDYYGCMGVDKVAGPEVLEPMQLNFFLSN 480

Query: 576 SLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSC 397
            +  ++ G  H   LT+  EVY+WG GE+GRLG  D +  +  P +V +     IV V C
Sbjct: 481 PVEQVSCGDNHVVVLTRNKEVYSWGCGEYGRLGL-DSEEDYYTPQKVDVPKALIIVAVQC 539

Query: 396 GGTHSVVLTSDGRIFS 349
           G   + +LT  G++ +
Sbjct: 540 GCDGTFLLTQSGKVLA 555



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 35/140 (25%), Positives = 66/140 (47%), Gaps = 12/140 (8%)
 Frame = -3

Query: 729 VSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGG 550
           V  ++ G  H + L+ ++ +++WG  EYG+LG+   +    P +V+    L +V +  G 
Sbjct: 482 VEQVSCGDNHVVVLTRNKEVYSWGCGEYGRLGLDSEEDYYTPQKVDVPKALIIVAVQCGC 541

Query: 549 WHSAALTKEGEVYAWGRGEHGRLGFG-------DDKSSHMVPLQVQL-----LAGEDIVQ 406
             +  LT+ G+V A G  E  +LG         + ++ H VP          L+   I  
Sbjct: 542 DGTFLLTQSGKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIRT 601

Query: 405 VSCGGTHSVVLTSDGRIFSY 346
           ++ G TH+  +   GR+ ++
Sbjct: 602 IAPGKTHTAAIDERGRLLTF 621



 Score = 47.0 bits (110), Expect = 6e-05
 Identities = 31/126 (24%), Positives = 58/126 (46%), Gaps = 6/126 (4%)
 Frame = -3

Query: 732 QVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEG-LSNLSLVDIAA 556
           ++  IA G  H  A+     L  +G N+ GQLG+G+ + R     + G L    ++ ++ 
Sbjct: 598 KIRTIAPGKTHTAAIDERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRVSC 657

Query: 555 GGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQ-----LLAGEDIVQVSCGG 391
           G   + A T +  ++AWG G +GRL     +  H   +          +   +  +SC G
Sbjct: 658 GDEFTIAATDDNHIFAWGNGGNGRLAMTPTERPHGSDICTSWPRPIFGSLHHVPDLSCRG 717

Query: 390 THSVVL 373
            H++++
Sbjct: 718 WHTILI 723



 Score = 30.8 bits (68), Expect = 4.7
 Identities = 21/80 (26%), Positives = 39/80 (48%), Gaps = 7/80 (8%)
 Frame = -3

Query: 741 GLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQP-------RSQPIRVEGLS 583
           G +QV  ++ G    +A + D  ++AWGN   G+L +  T+         S P  + G S
Sbjct: 648 GGKQVIRVSCGDEFTIAATDDNHIFAWGNGGNGRLAMTPTERPHGSDICTSWPRPIFG-S 706

Query: 582 NLSLVDIAAGGWHSAALTKE 523
              + D++  GWH+  + ++
Sbjct: 707 LHHVPDLSCRGWHTILIVEK 726

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>RCC1_XENLA (P25183) Regulator of chromosome condensation|
          Length = 424

 Score = 70.1 bits (170), Expect = 7e-12
 Identities = 49/148 (33%), Positives = 74/148 (50%), Gaps = 5/148 (3%)
 Frame = -3

Query: 660 GNNEYGQLGIG-DTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGR 484
           G  + GQLG+G D   R +P  V    ++  V  AAGG H+  L   G +Y +G  + G 
Sbjct: 47  GQGDVGQLGLGEDIMERKKPALVTLTEDI--VQAAAGGMHTVCLGASGSIYTFGCNDEGA 104

Query: 483 LGFG-DDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIF---SYXXXXXXXXXX 316
           LG    ++ S M P +V+L   E +VQVS G +H+  LT DGR+F   S+          
Sbjct: 105 LGRDTSEEGSEMQPGKVEL--AEKVVQVSAGDSHTAALTEDGRVFVFGSFRDNNGVIGLL 162

Query: 315 XRKVTTGHPMEVPINLPPPKTSTSSEGL 232
                +  P++V IN P  K ++ ++ L
Sbjct: 163 EPMKKSMVPVQVQINTPVIKIASGNDHL 190



 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 47/179 (26%), Positives = 81/179 (45%), Gaps = 2/179 (1%)
 Frame = -3

Query: 711 GAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNL--SLVDIAAGGWHSA 538
           GA+   A+S +  ++ +G + Y QLG  +TQ    P  +    N   S +  + G  H+ 
Sbjct: 253 GAYFTFAVSQEGHVYGFGLSNYHQLGTKNTQACYAPQNLTSFKNSTKSWIGFSGGQHHTV 312

Query: 537 ALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGR 358
            +  EG+ Y+ GR E+GRLG G++      P  +  L    I  V+ G + S  +++DG 
Sbjct: 313 CVDSEGKAYSLGRAEYGRLGLGENAEEQSEPTPIPDL--PKINSVASGASVSYAVSTDGC 370

Query: 357 IFSYXXXXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGRHTLAIV 181
           +F++             +  G   E  +  P   T    E   +   V+ GG+HT+ +V
Sbjct: 371 VFAW--------GMGTNLQLGTGEEEDVWSPEQMTGKHLEDR-EVLSVSSGGQHTVLLV 420



 Score = 47.8 bits (112), Expect = 4e-05
 Identities = 26/67 (38%), Positives = 38/67 (56%)
 Frame = -3

Query: 546 HSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTS 367
           H +  T  G+V   G+G+ G+LG G+D      P  V L   EDIVQ + GG H+V L +
Sbjct: 33  HPSHGTVGGQVLTLGQGDVGQLGLGEDIMERKKPALVTLT--EDIVQAAAGGMHTVCLGA 90

Query: 366 DGRIFSY 346
            G I+++
Sbjct: 91  SGSIYTF 97



 Score = 40.4 bits (93), Expect = 0.006
 Identities = 21/77 (27%), Positives = 43/77 (55%), Gaps = 2/77 (2%)
 Frame = -3

Query: 747 VQGLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEG--LSNLS 574
           +  L +++ +A GA  + A+S D  ++AWG     QLG G+ +    P ++ G  L +  
Sbjct: 346 IPDLPKINSVASGASVSYAVSTDGCVFAWGMGTNLQLGTGEEEDVWSPEQMTGKHLEDRE 405

Query: 573 LVDIAAGGWHSAALTKE 523
           ++ +++GG H+  L ++
Sbjct: 406 VLSVSSGGQHTVLLVRK 422

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>RCC1_MOUSE (Q8VE37) Regulator of chromosome condensation (Chromosome|
           condensation protein 1)
          Length = 421

 Score = 70.1 bits (170), Expect = 7e-12
 Identities = 48/148 (32%), Positives = 79/148 (53%), Gaps = 5/148 (3%)
 Frame = -3

Query: 660 GNNEYGQLGIGDTQ-PRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGR 484
           G  + GQLG+G++   R +P  V  L ++  V   AGG H+  L++ G+VY++G  + G 
Sbjct: 41  GQGDVGQLGLGESVLERKKPALVPLLQDV--VQAEAGGMHTVCLSQSGQVYSFGCNDEGA 98

Query: 483 LGFGDD-KSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIF---SYXXXXXXXXXX 316
           LG     + S MVP +V+L   E +VQVS G +H+  LT DGR+F   S+          
Sbjct: 99  LGRDTSVEGSEMVPGKVELQ--EKVVQVSAGDSHTAALTEDGRVFLWGSFRDNNGVIGLL 156

Query: 315 XRKVTTGHPMEVPINLPPPKTSTSSEGL 232
                +  P++V ++ P  K ++ ++ L
Sbjct: 157 EPMKKSMVPVQVQLDAPVVKVASGNDHL 184



 Score = 63.5 bits (153), Expect = 7e-10
 Identities = 46/179 (25%), Positives = 78/179 (43%), Gaps = 2/179 (1%)
 Frame = -3

Query: 711 GAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNL--SLVDIAAGGWHSA 538
           GA+   A+S +  ++ +G + Y QLG   T     P  +    N   S V  + G  H+ 
Sbjct: 248 GAYFTFAISREGHVYGFGLSNYHQLGTPGTGSCFIPQNLTSFKNSTKSWVGFSGGQHHTV 307

Query: 537 ALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGR 358
            +  EG+ Y+ GR E+GRLG G+      +P  +  L    +  V+CG +    ++ DGR
Sbjct: 308 CMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRL--PVVSSVACGASVGYAVSKDGR 365

Query: 357 IFSYXXXXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGRHTLAIV 181
           +F++           +      P+E+        T    E       V+ GG+HT+ +V
Sbjct: 366 VFAWGMGTNYQLGTGQDEDAWSPVEM--------TGKQLENRVVLT-VSSGGQHTVLLV 415



 Score = 47.8 bits (112), Expect = 4e-05
 Identities = 24/67 (35%), Positives = 38/67 (56%)
 Frame = -3

Query: 546 HSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTS 367
           H +  T+ G V   G+G+ G+LG G+       P  V LL  +D+VQ   GG H+V L+ 
Sbjct: 27  HRSHNTEPGLVLTLGQGDVGQLGLGESVLERKKPALVPLL--QDVVQAEAGGMHTVCLSQ 84

Query: 366 DGRIFSY 346
            G+++S+
Sbjct: 85  SGQVYSF 91



 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 25/77 (32%), Positives = 40/77 (51%), Gaps = 2/77 (2%)
 Frame = -3

Query: 747 VQGLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEG--LSNLS 574
           +  L  VS +A GA    A+S D  ++AWG     QLG G  +    P+ + G  L N  
Sbjct: 341 ISRLPVVSSVACGASVGYAVSKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMTGKQLENRV 400

Query: 573 LVDIAAGGWHSAALTKE 523
           ++ +++GG H+  L K+
Sbjct: 401 VLTVSSGGQHTVLLVKD 417

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>HIW_DROME (Q9NB71) Ubiquitin ligase protein highwire (EC 6.3.2.-) (Protein|
            pam/highwire/rpm-1)
          Length = 5233

 Score = 66.6 bits (161), Expect = 8e-11
 Identities = 34/84 (40%), Positives = 52/84 (61%)
 Frame = -3

Query: 729  VSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGG 550
            V  +A G  H + L++   ++ +G+N+YGQLG GD QP S P+RV+    +S   +AAG 
Sbjct: 968  VVQVACGLHHTVVLTLAGEVYTFGSNQYGQLGSGDLQPVSGPVRVQVPGAIS--QVAAGS 1025

Query: 549  WHSAALTKEGEVYAWGRGEHGRLG 478
             H+  LT +G VY +G  + G+LG
Sbjct: 1026 NHTVLLTSKGMVYTFGNYQKGQLG 1049



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 34/94 (36%), Positives = 55/94 (58%), Gaps = 3/94 (3%)
 Frame = -3

Query: 618  PRSQPIRVEGL---SNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMV 448
            PR  P+  + L   S+  +V +A G  H+  LT  GEVY +G  ++G+LG GD +     
Sbjct: 950  PRVAPLAPQLLQLTSSSPVVQVACGLHHTVVLTLAGEVYTFGSNQYGQLGSGDLQPVSG- 1008

Query: 447  PLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSY 346
            P++VQ+     I QV+ G  H+V+LTS G ++++
Sbjct: 1009 PVRVQVPGA--ISQVAAGSNHTVLLTSKGMVYTF 1040



 Score = 30.4 bits (67), Expect = 6.1
 Identities = 14/39 (35%), Positives = 24/39 (61%)
 Frame = -3

Query: 750  RVQGLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLG 634
            RVQ    +S +A G+ H + L+   +++ +GN + GQLG
Sbjct: 1011 RVQVPGAISQVAAGSNHTVLLTSKGMVYTFGNYQKGQLG 1049

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>RCC1_DROME (P25171) Regulator of chromosome condensation (Chromatin-binding|
           protein Bj1)
          Length = 547

 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 43/142 (30%), Positives = 70/142 (49%), Gaps = 9/142 (6%)
 Frame = -3

Query: 747 VQGLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLV 568
           V G+     I+ G  HNL L+    ++++G N+ G LG   ++  S+       S   L+
Sbjct: 70  VAGIPDAVDISAGGMHNLVLTKSGDIYSFGCNDEGALGRDTSEDGSE-------SKPDLI 122

Query: 567 D-------IAAGGWHSAALTKEGEVYAWG--RGEHGRLGFGDDKSSHMVPLQVQLLAGED 415
           D       I+AG  HSA L ++G V+AWG  R  HG +G   D +       + L+ G  
Sbjct: 123 DLPGKALCISAGDSHSACLLEDGRVFAWGSFRDSHGNMGLTIDGNKR---TPIDLMEGTV 179

Query: 414 IVQVSCGGTHSVVLTSDGRIFS 349
              ++ G  H V+LT+ G++F+
Sbjct: 180 CCSIASGADHLVILTTAGKVFT 201



 Score = 63.9 bits (154), Expect = 5e-10
 Identities = 39/111 (35%), Positives = 60/111 (54%), Gaps = 6/111 (5%)
 Frame = -3

Query: 660 GNNEYGQLGIG-DTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGR 484
           GN + GQLG+G D   R +   V G+ +   VDI+AGG H+  LTK G++Y++G  + G 
Sbjct: 48  GNGDVGQLGLGEDILERKRLSPVAGIPDA--VDISAGGMHNLVLTKSGDIYSFGCNDEGA 105

Query: 483 LG-----FGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSY 346
           LG      G +    ++ L  + L       +S G +HS  L  DGR+F++
Sbjct: 106 LGRDTSEDGSESKPDLIDLPGKALC------ISAGDSHSACLLEDGRVFAW 150



 Score = 60.8 bits (146), Expect = 4e-09
 Identities = 39/124 (31%), Positives = 66/124 (53%), Gaps = 2/124 (1%)
 Frame = -3

Query: 738 LEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQP-RSQPIRVEGLSNLSLVDI 562
           L+ +  IA G  H + L+ D      G  EYG+LG+GD +    +P  V+ L+   +V +
Sbjct: 292 LKDIRHIAGGQHHTVILTTDLKCSVVGRPEYGRLGLGDVKDVVEKPTIVKKLTE-KIVSV 350

Query: 561 AAGGWHSAALTKEGEVYAWGRGEHGRLGFGD-DKSSHMVPLQVQLLAGEDIVQVSCGGTH 385
             G   S A+T +G++Y+WG G + +LG GD D     + +  +   G+ ++  S GG H
Sbjct: 351 GCGEVCSYAVTIDGKLYSWGSGVNNQLGVGDGDDELEPIVVVSKNTQGKHMLLASGGGQH 410

Query: 384 SVVL 373
           ++ L
Sbjct: 411 AIFL 414



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 42/117 (35%), Positives = 62/117 (52%), Gaps = 3/117 (2%)
 Frame = -3

Query: 687 SVDRILWAWGNNEYGQLGIGDTQPRS---QPIRVEGLSNLSLVDIAAGGWHSAALTKEGE 517
           S  +++WA G N + QL   +T+ +     PI+ E L ++    IA G  H+  LT + +
Sbjct: 258 SQTQVIWATGLNNFKQLA-HETKGKEFALTPIKTE-LKDIR--HIAGGQHHTVILTTDLK 313

Query: 516 VYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSY 346
               GR E+GRLG GD K     P  V+ L  E IV V CG   S  +T DG+++S+
Sbjct: 314 CSVVGRPEYGRLGLGDVKDVVEKPTIVKKLT-EKIVSVGCGEVCSYAVTIDGKLYSW 369



 Score = 40.8 bits (94), Expect = 0.005
 Identities = 23/60 (38%), Positives = 34/60 (56%), Gaps = 1/60 (1%)
 Frame = -3

Query: 522 GEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAG-EDIVQVSCGGTHSVVLTSDGRIFSY 346
           G V   G G+ G+LG G+D        ++  +AG  D V +S GG H++VLT  G I+S+
Sbjct: 42  GNVLVCGNGDVGQLGLGEDILERK---RLSPVAGIPDAVDISAGGMHNLVLTKSGDIYSF 98



 Score = 38.1 bits (87), Expect = 0.029
 Identities = 20/72 (27%), Positives = 37/72 (51%), Gaps = 2/72 (2%)
 Frame = -3

Query: 735 EQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRV--EGLSNLSLVDI 562
           E++  +  G   + A+++D  L++WG+    QLG+GD     +PI V  +      ++  
Sbjct: 345 EKIVSVGCGEVCSYAVTIDGKLYSWGSGVNNQLGVGDGDDELEPIVVVSKNTQGKHMLLA 404

Query: 561 AAGGWHSAALTK 526
           + GG H+  L K
Sbjct: 405 SGGGQHAIFLVK 416

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>RCC1_YEAST (P21827) Regulator of chromosome condensation (PRP20 protein)|
           (Pheromone response pathway component SRM1)
          Length = 482

 Score = 64.7 bits (156), Expect = 3e-10
 Identities = 45/147 (30%), Positives = 70/147 (47%), Gaps = 15/147 (10%)
 Frame = -3

Query: 741 GLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIG----DTQPRSQPIRVEGLSNLS 574
           GL  V  IA G  H  AL+ D  L +WG N++GQ G+     D    ++P R+    N+ 
Sbjct: 272 GLRHVKYIASGENHCFALTKDNKLVSWGLNQFGQCGVSEDVEDGALVTKPKRLALPDNVV 331

Query: 573 LVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDK-----------SSHMVPLQVQLL 427
           +  IAAG  HS  L+++G++Y+ GR +   +G   D             +  VPL  +L 
Sbjct: 332 IRSIAAGEHHSLILSQDGDLYSCGRLDMFEVGIPKDNLPEYTYKDVHGKARAVPLPTKLN 391

Query: 426 AGEDIVQVSCGGTHSVVLTSDGRIFSY 346
                  V+ G  HSV +  +G  +S+
Sbjct: 392 NVPKFKSVAAGSHHSVAVAQNGIAYSW 418



 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 48/161 (29%), Positives = 71/161 (44%), Gaps = 32/161 (19%)
 Frame = -3

Query: 732 QVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQ------------------ 607
           ++   AVG  H LAL  +  +W+WG N+ G LG   +  + Q                  
Sbjct: 85  KIISFAVGGMHTLALDEESNVWSWGCNDVGALGRDTSNAKEQLKDMDADDSSDDEDGDLN 144

Query: 606 -----PIRV--EGLSNLS----LVDIAAGGWHSAALTKEGEVYAWG--RGEHGRLGFGDD 466
                P ++  E    L+    +V +AA    S AL   GEVYAWG  R   G LGF  D
Sbjct: 145 ELESTPAKIPRESFPPLAEGHKVVQLAATDNMSCALFSNGEVYAWGTFRCNEGILGFYQD 204

Query: 465 K-SSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSY 346
           K      P +V   +  +IVQ++ G  H + L  +G +F++
Sbjct: 205 KIKIQKTPWKVPTFSKYNIVQLAPGKDHILFLDEEGMVFAW 245



 Score = 58.2 bits (139), Expect = 3e-08
 Identities = 39/133 (29%), Positives = 70/133 (52%), Gaps = 6/133 (4%)
 Frame = -3

Query: 729 VSMIAVGAFHNLALSVDRILWAWGNNEYGQLG---IGDTQPRSQPIRVEGLSNLSLVDIA 559
           +  +A G  H L L  + +++AWGN +  QLG   +   + ++   R  GL ++    IA
Sbjct: 223 IVQLAPGKDHILFLDEEGMVFAWGNGQQNQLGRKVMERFRLKTLDPRPFGLRHVKY--IA 280

Query: 558 AGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGED---IVQVSCGGT 388
           +G  H  ALTK+ ++ +WG  + G+ G  +D     +  + + LA  D   I  ++ G  
Sbjct: 281 SGENHCFALTKDNKLVSWGLNQFGQCGVSEDVEDGALVTKPKRLALPDNVVIRSIAAGEH 340

Query: 387 HSVVLTSDGRIFS 349
           HS++L+ DG ++S
Sbjct: 341 HSLILSQDGDLYS 353



 Score = 57.4 bits (137), Expect = 5e-08
 Identities = 43/131 (32%), Positives = 63/131 (48%), Gaps = 14/131 (10%)
 Frame = -3

Query: 729 VSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIG-DTQPRSQPIRVEG----------LS 583
           +  IA G  H+L LS D  L++ G  +  ++GI  D  P      V G          L+
Sbjct: 332 IRSIAAGEHHSLILSQDGDLYSCGRLDMFEVGIPKDNLPEYTYKDVHGKARAVPLPTKLN 391

Query: 582 NL-SLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGED--I 412
           N+     +AAG  HS A+ + G  Y+WG GE   +G G  +    VP +++  A +D  I
Sbjct: 392 NVPKFKSVAAGSHHSVAVAQNGIAYSWGFGETYAVGLGPFEDDTEVPTRIKNTATQDHNI 451

Query: 411 VQVSCGGTHSV 379
           + V CGG  SV
Sbjct: 452 ILVGCGGQFSV 462



 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 33/114 (28%), Positives = 54/114 (47%), Gaps = 5/114 (4%)
 Frame = -3

Query: 672 LWAWGN---NEYGQLGIGDTQPRSQ--PIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYA 508
           ++AWG    NE G LG    + + Q  P +V   S  ++V +A G  H   L +EG V+A
Sbjct: 186 VYAWGTFRCNE-GILGFYQDKIKIQKTPWKVPTFSKYNIVQLAPGKDHILFLDEEGMVFA 244

Query: 507 WGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSY 346
           WG G+  +LG    +   +  L  +      +  ++ G  H   LT D ++ S+
Sbjct: 245 WGNGQQNQLGRKVMERFRLKTLDPRPFGLRHVKYIASGENHCFALTKDNKLVSW 298



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 35/156 (22%), Positives = 62/156 (39%), Gaps = 36/156 (23%)
 Frame = -3

Query: 705 FHNLALSVDRI-LWAWGNNEYGQLGIGDT-------QPRSQPIRVEGLSNLSLVDIAAGG 550
           + ++ LSV  + ++ WG     +LG+G         +PR  P          ++  A GG
Sbjct: 36  YKHMYLSVQPLDIFCWGTGSMCELGLGPLAKNKEVKRPRLNPFLPR--DEAKIISFAVGG 93

Query: 549 WHSAALTKEGEVYAWGRGEHGRLG-----------------FGDDKSSHMVPLQ------ 439
            H+ AL +E  V++WG  + G LG                   DD+   +  L+      
Sbjct: 94  MHTLALDEESNVWSWGCNDVGALGRDTSNAKEQLKDMDADDSSDDEDGDLNELESTPAKI 153

Query: 438 -----VQLLAGEDIVQVSCGGTHSVVLTSDGRIFSY 346
                  L  G  +VQ++     S  L S+G ++++
Sbjct: 154 PRESFPPLAEGHKVVQLAATDNMSCALFSNGEVYAW 189



 Score = 30.8 bits (68), Expect = 4.7
 Identities = 15/75 (20%), Positives = 42/75 (56%), Gaps = 3/75 (4%)
 Frame = -3

Query: 750 RVQGLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQ-PIRVEGLS--N 580
           ++  + +   +A G+ H++A++ + I ++WG  E   +G+G  +  ++ P R++  +  +
Sbjct: 389 KLNNVPKFKSVAAGSHHSVAVAQNGIAYSWGFGETYAVGLGPFEDDTEVPTRIKNTATQD 448

Query: 579 LSLVDIAAGGWHSAA 535
            +++ +  GG  S +
Sbjct: 449 HNIILVGCGGQFSVS 463

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>WBS16_MOUSE (Q9CYF5) Williams-Beuren syndrome chromosome region 16 protein|
           homolog
          Length = 461

 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 51/181 (28%), Positives = 83/181 (45%), Gaps = 4/181 (2%)
 Frame = -3

Query: 732 QVSMIAVGAFHNLALSVDRILWAWGNNEYGQLG--IGDTQPRSQPIRVEGLSNL--SLVD 565
           +V  ++ G  H+L L+    +++ GNN +GQ G  + + +  S+  +V  + +    +V 
Sbjct: 172 KVLQVSCGRAHSLVLTDREGVFSMGNNSHGQCGRKVVEDEVYSESHKVHRMQDFDGQVVQ 231

Query: 564 IAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTH 385
           +  G  HS  LT +GEVY+ G G  G+ G G    +         LAG  +VQV+  G  
Sbjct: 232 VVCGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSTPSKLGGDLAGVTVVQVATYGDC 291

Query: 384 SVVLTSDGRIFSYXXXXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACG 205
            + L++DG +F +             VT    + VP  LP         G+ +   VACG
Sbjct: 292 CLALSADGGVFGW---GNSEYLQLASVTDSTQVNVPRCLP-------FSGVGKVKQVACG 341

Query: 204 G 202
           G
Sbjct: 342 G 342



 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 39/128 (30%), Positives = 65/128 (50%), Gaps = 1/128 (0%)
 Frame = -3

Query: 732 QVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEG-LSNLSLVDIAA 556
           QV  +  G  H+L L+    +++ G    GQ G+G     S P ++ G L+ +++V +A 
Sbjct: 228 QVVQVVCGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSTPSKLGGDLAGVTVVQVAT 287

Query: 555 GGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVV 376
            G    AL+ +G V+ WG  E+ +L    D +   VP  +       + QV+CGGT   V
Sbjct: 288 YGDCCLALSADGGVFGWGNSEYLQLASVTDSTQVNVPRCLPFSGVGKVKQVACGGTGCAV 347

Query: 375 LTSDGRIF 352
           L ++G +F
Sbjct: 348 LNAEGHVF 355



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 42/132 (31%), Positives = 62/132 (46%), Gaps = 9/132 (6%)
 Frame = -3

Query: 741 GLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQ-----PRSQPIRVEGLSNL 577
           G+ +V  +A G      L+ +  ++ WG   YG LG G        P   P  + GL+  
Sbjct: 331 GVGKVKQVACGGTGCAVLNAEGHVFVWG---YGILGKGPKLLETAIPEMIPPTLFGLTEF 387

Query: 576 S----LVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIV 409
           +    +  I  G  H AALT +GE++ WG+   G LG G  +  +  P +V  + GE  V
Sbjct: 388 NPEVQVSQIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYF-PWRV-TMPGEP-V 444

Query: 408 QVSCGGTHSVVL 373
            V+CG  H V L
Sbjct: 445 DVACGVDHMVTL 456



 Score = 46.6 bits (109), Expect = 8e-05
 Identities = 35/125 (28%), Positives = 57/125 (45%), Gaps = 17/125 (13%)
 Frame = -3

Query: 672 LWAWGNNEYGQLGIGDT------------QPRSQPIRVEGLSNLSLVDIAAGGWHSAALT 529
           +W  G N+  QLG   +            +P   P+ ++      ++ ++ G  HS  LT
Sbjct: 128 VWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPVPLPLDRPQETKVLQVSCGRAHSLVLT 187

Query: 528 KEGEVYAWGRGEHGRLG---FGDD--KSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSD 364
               V++ G   HG+ G     D+    SH V  ++Q   G+ +VQV CG  HS+ LT  
Sbjct: 188 DREGVFSMGNNSHGQCGRKVVEDEVYSESHKVH-RMQDFDGQ-VVQVVCGQDHSLFLTDK 245

Query: 363 GRIFS 349
           G ++S
Sbjct: 246 GEVYS 250



 Score = 33.5 bits (75), Expect = 0.72
 Identities = 37/144 (25%), Positives = 58/144 (40%), Gaps = 29/144 (20%)
 Frame = -3

Query: 693 ALSVDRILWAWGNNEYGQLGI-------------GDTQPRSQ----PIRVEGLSNLSLVD 565
           A   DR+ + WG +  G LG+                +PR +    P R+E    +S   
Sbjct: 52  AARADRV-FVWGFSFSGALGVPSFVVPSSGPGPRAGLRPRRRIQPVPYRLELDHKISSAA 110

Query: 564 IAAGGWHSAALTKE-GEVYAWGRGEHGRLGFGDDKSSHM-----------VPLQVQLLAG 421
              G    ++ TK+  +V+  G  +  +LGF   +               VPL +     
Sbjct: 111 CGYGFTLLSSKTKDVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPVPLPLDRPQE 170

Query: 420 EDIVQVSCGGTHSVVLTSDGRIFS 349
             ++QVSCG  HS+VLT    +FS
Sbjct: 171 TKVLQVSCGRAHSLVLTDREGVFS 194

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>WBS16_HUMAN (Q96I51) Williams-Beuren syndrome chromosome region 16 protein|
          Length = 464

 Score = 63.2 bits (152), Expect = 9e-10
 Identities = 50/181 (27%), Positives = 83/181 (45%), Gaps = 4/181 (2%)
 Frame = -3

Query: 732 QVSMIAVGAFHNLALSVDRILWAWGNNEYGQLG--IGDTQPRSQPIRVEGLSNL--SLVD 565
           +V  ++ G  H+L L+    +++ GNN YGQ G  + + +  S+  RV  + +    +V 
Sbjct: 175 RVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQ 234

Query: 564 IAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTH 385
           +A G  HS  LT +GEVY+ G G  G+ G G    +         LAG +++QV+  G  
Sbjct: 235 VACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDC 294

Query: 384 SVVLTSDGRIFSYXXXXXXXXXXXRKVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACG 205
            + +++DG +F +             VT    + VP  L          G+ +    ACG
Sbjct: 295 CLAVSADGGLFGW---GNSEYLQLASVTDSTQVNVPRCL-------HFSGVGKVRQAACG 344

Query: 204 G 202
           G
Sbjct: 345 G 345



 Score = 60.5 bits (145), Expect = 6e-09
 Identities = 36/128 (28%), Positives = 64/128 (50%), Gaps = 1/128 (0%)
 Frame = -3

Query: 732 QVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEG-LSNLSLVDIAA 556
           QV  +A G  H+L L+    +++ G    GQ G+G     S P ++ G L+ ++++ +A 
Sbjct: 231 QVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVAT 290

Query: 555 GGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVV 376
            G    A++ +G ++ WG  E+ +L    D +   VP  +       + Q +CGGT   V
Sbjct: 291 YGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAV 350

Query: 375 LTSDGRIF 352
           L  +G +F
Sbjct: 351 LNGEGHVF 358



 Score = 46.6 bits (109), Expect = 8e-05
 Identities = 42/132 (31%), Positives = 61/132 (46%), Gaps = 9/132 (6%)
 Frame = -3

Query: 741 GLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIG-----DTQPRSQPIRVEGLSN- 580
           G+ +V   A G      L+ +  ++ WG   YG LG G        P   P  + GL+  
Sbjct: 334 GVGKVRQAACGGTGCAVLNGEGHVFVWG---YGILGKGPNLVESAVPEMIPPTLFGLTEF 390

Query: 579 ---LSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIV 409
              + +  I  G  H AALT +GE++ WG+   G LG G  +  +  P +V  + GE  V
Sbjct: 391 NPEIQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYF-PWRV-TMPGEP-V 447

Query: 408 QVSCGGTHSVVL 373
            V+CG  H V L
Sbjct: 448 DVACGVDHMVTL 459



 Score = 40.8 bits (94), Expect = 0.005
 Identities = 32/125 (25%), Positives = 57/125 (45%), Gaps = 17/125 (13%)
 Frame = -3

Query: 672 LWAWGNNEYGQLGIGDT------------QPRSQPIRVEGLSNLSLVDIAAGGWHSAALT 529
           +W  G N+  QLG   +            +P    + ++      ++ ++ G  HS  LT
Sbjct: 131 VWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPVSLPLDRPQETRVLQVSCGRAHSLVLT 190

Query: 528 KEGEVYAWGRGEHGRLGFGDDKS-----SHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSD 364
               V++ G   +G+ G    ++     SH V  ++Q   G+ +VQV+CG  HS+ LT  
Sbjct: 191 DREGVFSMGNNSYGQCGRKVVENEIYSESHRVH-RMQDFDGQ-VVQVACGQDHSLFLTDK 248

Query: 363 GRIFS 349
           G ++S
Sbjct: 249 GEVYS 253

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>MYCB2_HUMAN (O75592) Probable ubiquitin ligase protein MYCBP2 (EC 6.3.2.-) (Myc|
            binding protein 2) (Protein associated with Myc)
            (Pam/highwire/rpm-1 protein)
          Length = 4641

 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 43/132 (32%), Positives = 64/132 (48%), Gaps = 3/132 (2%)
 Frame = -3

Query: 579  LSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVS 400
            L  V ++ G  HS  L + G+VY +G G+HG+LG G D +S   P  VQ L G    QV+
Sbjct: 902  LRAVQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHG-DVNSRGCPTLVQALPGPS-TQVT 959

Query: 399  CGGTHSVVLTSDGRIFSYXXXXXXXXXXXRKVTTGHP-MEVPI--NLPPPKTSTSSEGLW 229
             G  H+ VL  DG++F++            K   G P ++VP     P P  +  S+   
Sbjct: 960  AGSNHTAVLLMDGQVFTF--------GSFSKGQLGRPILDVPYWNAKPAPMPNIGSKYGR 1011

Query: 228  QANYVACGGRHT 193
            +A ++   G  T
Sbjct: 1012 KATWIGASGDQT 1023



 Score = 50.1 bits (118), Expect = 7e-06
 Identities = 26/81 (32%), Positives = 44/81 (54%)
 Frame = -3

Query: 720  IAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHS 541
            ++ G  H++ L  +  ++ +G  ++GQLG GD   R  P  V+ L   S   + AG  H+
Sbjct: 907  VSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQALPGPS-TQVTAGSNHT 965

Query: 540  AALTKEGEVYAWGRGEHGRLG 478
            A L  +G+V+ +G    G+LG
Sbjct: 966  AVLLMDGQVFTFGSFSKGQLG 986



 Score = 36.2 bits (82), Expect = 0.11
 Identities = 28/123 (22%), Positives = 56/123 (45%), Gaps = 4/123 (3%)
 Frame = -3

Query: 702 HNLALSVDRILWAWGNNEYGQLGIGDTQPRS----QPIRVEGLSNLSLVDIAAGGWHSAA 535
           H L ++ D  ++  G+   G+ G      R     +P ++  +    +V  A     S+ 
Sbjct: 555 HALLVAEDGSIFFTGSASKGEDGESTKSRRQSKPYKPKKIIKMEGKIVVYTACNNGSSSV 614

Query: 534 LTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRI 355
           ++K+GE+Y +G+          D SS +  L+     G  + QV+ G  H+ VL  +G +
Sbjct: 615 ISKDGELYMFGKD-----AIYSDSSSLVTDLK-----GHFVTQVAMGKAHTCVLMKNGEV 664

Query: 354 FSY 346
           +++
Sbjct: 665 WTF 667

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>RPM1_CAEEL (Q17551) Ubiquitin ligase protein rpm-1 (EC 6.3.2.-)|
            (Pam/highwire/rpm-1 protein) (Regulator of presynaptic
            morphology protein 1) (Synapse defective protein 3)
          Length = 3766

 Score = 60.5 bits (145), Expect = 6e-09
 Identities = 30/84 (35%), Positives = 52/84 (61%)
 Frame = -3

Query: 732  QVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAG 553
            +VS ++ G FH + L+ DR ++ +G+N +GQLG+GDT  ++ P +V   S+  +V +AAG
Sbjct: 768  KVSSVSCGNFHTVLLASDRRVFTFGSNCHGQLGVGDTLSKNTPQQVILPSDTVIVQVAAG 827

Query: 552  GWHSAALTKEGEVYAWGRGEHGRL 481
              H+     +G V+ +G    G+L
Sbjct: 828  SNHTILRANDGSVFTFGAFGKGQL 851



 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 28/89 (31%), Positives = 51/89 (57%)
 Frame = -3

Query: 612  SQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQ 433
            S+ I  +G  ++ +  ++ G +H+  L  +  V+ +G   HG+LG GD  S +  P QV 
Sbjct: 756  SRVILSQGPHDVKVSSVSCGNFHTVLLASDRRVFTFGSNCHGQLGVGDTLSKN-TPQQVI 814

Query: 432  LLAGEDIVQVSCGGTHSVVLTSDGRIFSY 346
            L +   IVQV+ G  H+++  +DG +F++
Sbjct: 815  LPSDTVIVQVAAGSNHTILRANDGSVFTF 843

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>MYCB2_MOUSE (Q7TPH6) Probable ubiquitin ligase protein MYCBP2 (EC 6.3.2.-) (Myc|
            binding protein 2) (Protein associated with Myc)
            (Pam/highwire/rpm-1 protein)
          Length = 4711

 Score = 58.2 bits (139), Expect = 3e-08
 Identities = 41/132 (31%), Positives = 63/132 (47%), Gaps = 3/132 (2%)
 Frame = -3

Query: 579  LSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVS 400
            L  V ++ G  HS  L + G+VY +G G+HG+LG G D +S   P  VQ L G    QV+
Sbjct: 902  LRAVQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHG-DVNSRGCPTLVQALPGPS-TQVT 959

Query: 399  CGGTHSVVLTSDGRIFSYXXXXXXXXXXXRKVTTGHP-MEVPI--NLPPPKTSTSSEGLW 229
                H+ VL  DG++F++            K   G P +++P     P P  +  S+   
Sbjct: 960  ACSNHTAVLLMDGQVFTF--------GSFSKGQLGRPILDIPYWNAKPAPMPNIGSKYGR 1011

Query: 228  QANYVACGGRHT 193
            +A ++   G  T
Sbjct: 1012 KATWIGASGDQT 1023



 Score = 46.6 bits (109), Expect = 8e-05
 Identities = 25/81 (30%), Positives = 43/81 (53%)
 Frame = -3

Query: 720  IAVGAFHNLALSVDRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHS 541
            ++ G  H++ L  +  ++ +G  ++GQLG GD   R  P  V+ L   S   + A   H+
Sbjct: 907  VSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQALPGPS-TQVTACSNHT 965

Query: 540  AALTKEGEVYAWGRGEHGRLG 478
            A L  +G+V+ +G    G+LG
Sbjct: 966  AVLLMDGQVFTFGSFSKGQLG 986



 Score = 35.4 bits (80), Expect = 0.19
 Identities = 29/123 (23%), Positives = 55/123 (44%), Gaps = 4/123 (3%)
 Frame = -3

Query: 702 HNLALSVDRILWAWGNNEYGQLGIGDTQPRS----QPIRVEGLSNLSLVDIAAGGWHSAA 535
           H L ++ D  ++  G+   G+ G      R     +P ++  +    +V  A     S+ 
Sbjct: 555 HALLVAEDGSVFFTGSASKGEDGESTKSRRQSKPYKPKKIIKMEGKIVVYTACNNGSSSV 614

Query: 534 LTKEGEVYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRI 355
           ++K+GE+Y +G+          D SS      V  L G  + QV+ G  H+ VL  +G +
Sbjct: 615 ISKDGELYMFGKD-----AIYSDSSS-----LVSDLKGHFVTQVAMGKAHTCVLMKNGEV 664

Query: 354 FSY 346
           +++
Sbjct: 665 WTF 667

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>ATS1_YEAST (P31386) Protein ATS1 (Alpha-tubulin suppressor 1)|
          Length = 333

 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 33/110 (30%), Positives = 53/110 (48%), Gaps = 3/110 (2%)
 Frame = -3

Query: 672 LWAWGNNEYGQLGIGDTQPRSQPIR-VEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRG 496
           ++A+G+N   QLG+G  +    P R V G     +  IA GG HS  LT +G +   G  
Sbjct: 4   VYAFGSNGQRQLGLGHDEDMDTPQRSVPGDDGAIVRKIACGGNHSVMLTNDGNLVGCGDN 63

Query: 495 EHGRLGFGD--DKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIF 352
             G L       +     P++V       +V V+CG   +V++ +DGR++
Sbjct: 64  RRGELDSAQALRQVHDWRPVEVP----APVVDVACGWDTTVIVDADGRVW 109



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 29/111 (26%), Positives = 45/111 (40%)
 Frame = -3

Query: 516 VYAWGRGEHGRLGFGDDKSSHMVPLQVQLLAGEDIVQVSCGGTHSVVLTSDGRIFSYXXX 337
           VYA+G     +LG G D+        V    G  + +++CGG HSV+LT+DG +      
Sbjct: 4   VYAFGSNGQRQLGLGHDEDMDTPQRSVPGDDGAIVRKIACGGNHSVMLTNDGNLVGCGDN 63

Query: 336 XXXXXXXXRKVTTGHPMEVPINLPPPKTSTSSEGLWQANYVACGGRHTLAI 184
                   + +   H    P+ +P P              VACG   T+ +
Sbjct: 64  RRGELDSAQALRQVHDWR-PVEVPAPVVD-----------VACGWDTTVIV 102

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>RCC1_CAEEL (Q18211) Regulator of chromosome condensation (Cell cycle|
           regulatory protein) (RCC1 homolog)
          Length = 569

 Score = 42.7 bits (99), Expect = 0.001
 Identities = 42/146 (28%), Positives = 62/146 (42%), Gaps = 11/146 (7%)
 Frame = -3

Query: 750 RVQGLEQVSMIAVGAFHNL---ALSVDRILWAWGNNEYGQLGIGDTQ-PRSQPI-RVEGL 586
           +  G +Q  ++A    ++L   ++  DR+L        G  G   T+ PR   I   EGL
Sbjct: 126 KTPGRKQAKLVAPLLTYDLFAPSIIGDRVLSCGEGEALGHPGRTTTKKPRKVDIFEEEGL 185

Query: 585 SNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGF------GDDKSSHMVPLQVQLLA 424
             L  V   AGG HSA LT EGEVY  G  E G +        G       V  +  +  
Sbjct: 186 KPLQAV---AGGVHSAVLTSEGEVYMCGINEKGTVPAEGVEKEGSTDEFAKVKFEEDIEK 242

Query: 423 GEDIVQVSCGGTHSVVLTSDGRIFSY 346
              IV ++ G + +  LT  G + ++
Sbjct: 243 EGKIVMLAAGASFTAALTDQGSVIAW 268



 Score = 40.4 bits (93), Expect = 0.006
 Identities = 35/143 (24%), Positives = 66/143 (46%), Gaps = 10/143 (6%)
 Frame = -3

Query: 744 QGLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQL---GIGDTQPRSQPIRVEGLSNLS 574
           +GL+ +  +A G  H+  L+ +  ++  G NE G +   G+       +  +V+   ++ 
Sbjct: 183 EGLKPLQAVA-GGVHSAVLTSEGEVYMCGINEKGTVPAEGVEKEGSTDEFAKVKFEEDIE 241

Query: 573 ----LVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFGDDKSSHMV---PLQVQLLAGED 415
               +V +AAG   +AALT +G V AWG   +           H +   P+ +   A   
Sbjct: 242 KEGKIVMLAAGASFTAALTDQGSVIAWGNLRNSNGNVDVHPLLHKMQEAPVVIVHQAKRK 301

Query: 414 IVQVSCGGTHSVVLTSDGRIFSY 346
           IV+++ G  H V+L   G + ++
Sbjct: 302 IVKIAAGENHLVMLDEKGCLLTF 324



 Score = 39.3 bits (90), Expect = 0.013
 Identities = 36/134 (26%), Positives = 58/134 (43%), Gaps = 11/134 (8%)
 Frame = -3

Query: 741 GLEQVSMIAVGAFHNLALSVDRILWAWGNNEYGQLGIG------DTQPRSQPIRVEGLSN 580
           G E+  +   G  H + L  D  ++A G N    LG+G      D Q        E   +
Sbjct: 432 GAERTFVNIEGVQHVVILGSDGKVFAMGKNTDNALGLGNWTGKDDQQHWLYDTIQEIEFD 491

Query: 579 LSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFG-DDKSSHMVPLQVQL----LAGED 415
             +V ++A    S A +++G  YAWG    G+LG G  D+   MV    ++    L G  
Sbjct: 492 SKIVGVSAKLATSIAWSEDGTAYAWGFDTTGQLGLGLKDEDEKMVSKPEEISSAHLDGYS 551

Query: 414 IVQVSCGGTHSVVL 373
           I+  S    H++++
Sbjct: 552 IIGASISDQHTLII 565



 Score = 31.2 bits (69), Expect = 3.6
 Identities = 34/144 (23%), Positives = 57/144 (39%), Gaps = 19/144 (13%)
 Frame = -3

Query: 720 IAVGAFHNLALSVDRILWAWGNNEYGQLGI-------GDTQPRSQPIRV-------EGLS 583
           +    F  +    D   +A+G N Y QLGI       G     ++ +RV          +
Sbjct: 374 VFASGFWTIVHGEDGKYYAFGLNNYAQLGIKVDEADVGQDGQDNRELRVFLPAEAPAFGA 433

Query: 582 NLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGRLGFG-----DDKSSHMVPLQVQLLAGE 418
             + V+I  G  H   L  +G+V+A G+     LG G     DD+   +     ++    
Sbjct: 434 ERTFVNI-EGVQHVVILGSDGKVFAMGKNTDNALGLGNWTGKDDQQHWLYDTIQEIEFDS 492

Query: 417 DIVQVSCGGTHSVVLTSDGRIFSY 346
            IV VS     S+  + DG  +++
Sbjct: 493 KIVGVSAKLATSIAWSEDGTAYAW 516

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>FBX24_HUMAN (O75426) F-box only protein 24|
          Length = 580

 Score = 39.3 bits (90), Expect = 0.013
 Identities = 29/81 (35%), Positives = 39/81 (48%), Gaps = 4/81 (4%)
 Frame = -3

Query: 660 GNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEG----EVYAWGRGE 493
           GNN YGQLG GD   R +P +V  L     + +  G  HS  L++      E+   G G 
Sbjct: 382 GNNRYGQLGTGDKMDRGEPTQVCYLQR--PITLWCGLNHSLVLSQSSEFSKELLGCGCGA 439

Query: 492 HGRLGFGDDKSSHMVPLQVQL 430
            GRL      S+  V LQV++
Sbjct: 440 GGRLPGWPKGSASFVKLQVKV 460

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>FBX24_MOUSE (Q9D417) F-box only protein 24|
          Length = 589

 Score = 37.7 bits (86), Expect = 0.038
 Identities = 27/81 (33%), Positives = 38/81 (46%), Gaps = 4/81 (4%)
 Frame = -3

Query: 660 GNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEG----EVYAWGRGE 493
           GNN YGQLG GD   R +P +V  L     + +  G  HS  L++      E+   G G 
Sbjct: 392 GNNRYGQLGTGDKMDRGEPTQVHYLQR--PIALWCGLNHSLVLSQTSDFSKELLGCGCGA 449

Query: 492 HGRLGFGDDKSSHMVPLQVQL 430
            GRL      S+  V L +++
Sbjct: 450 GGRLPGWPKGSASFVKLHIKV 470

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>CRI4_MAIZE (O24585) Putative receptor protein kinase CRINKLY4 precursor (EC|
           2.7.11.1)
          Length = 901

 Score = 35.8 bits (81), Expect = 0.15
 Identities = 22/80 (27%), Positives = 36/80 (45%), Gaps = 1/80 (1%)
 Frame = -3

Query: 735 EQVSMIAVGAFHNLALSV-DRILWAWGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIA 559
           E VS ++ G+  N  L   +R ++ WG+      G+    PR          +L    I 
Sbjct: 160 EAVSTVSAGSVFNCGLFARNRTVFCWGDETVS--GVVGLAPR----------DLHFQSIG 207

Query: 558 AGGWHSAALTKEGEVYAWGR 499
           AGG+H   + +  +V+ WGR
Sbjct: 208 AGGYHVCGVLENAQVFCWGR 227

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>YB9W_YEAST (P38352) F-box protein YBR280C|
          Length = 637

 Score = 35.4 bits (80), Expect = 0.19
 Identities = 24/87 (27%), Positives = 41/87 (47%), Gaps = 19/87 (21%)
 Frame = -3

Query: 735 EQVSMIAVGAFHNLALSVDRILWAWG--NNEYGQLGIGDTQPRSQPIRV---EGLSNLSL 571
           E V  +A G +H +AL+    L++WG  + + G LG+G ++     + +   EG  N+ +
Sbjct: 546 ENVISVASGDYHTVALTERGHLYSWGIESQDCGCLGLGPSEKIVNELHIGNWEGQRNIRV 605

Query: 570 V--------------DIAAGGWHSAAL 532
           V               + AGGW + AL
Sbjct: 606 VKPTKIELPEDYICVSVTAGGWQTGAL 632



 Score = 35.4 bits (80), Expect = 0.19
 Identities = 15/39 (38%), Positives = 26/39 (66%), Gaps = 2/39 (5%)
 Frame = -3

Query: 582 NLSLVDIAAGGWHSAALTKEGEVYAWG--RGEHGRLGFG 472
           N +++ +A+G +H+ ALT+ G +Y+WG    + G LG G
Sbjct: 545 NENVISVASGDYHTVALTERGHLYSWGIESQDCGCLGLG 583

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>POF9_SCHPO (O74381) F-box protein pof9|
          Length = 467

 Score = 34.7 bits (78), Expect = 0.32
 Identities = 25/85 (29%), Positives = 37/85 (43%), Gaps = 19/85 (22%)
 Frame = -3

Query: 729 VSMIAVGAFHNLALSVDRILWAWG--NNEYGQLGIG---------DTQPRSQPIRVEGLS 583
           +  +A G  H+L L+ D  +W+WG      G LG+G         D    S P     + 
Sbjct: 339 IKQLAHGDHHHLYLTSDHSIWSWGVELRYCGCLGLGSLHLQEQTSDPSIVSDPRTARNIV 398

Query: 582 NL--------SLVDIAAGGWHSAAL 532
           ++        +   +AAGGW SAAL
Sbjct: 399 SIPHQIHFSGTCYSVAAGGWQSAAL 423



 Score = 30.4 bits (67), Expect = 6.1
 Identities = 24/88 (27%), Positives = 39/88 (44%), Gaps = 5/88 (5%)
 Frame = -3

Query: 750 RVQGLEQVSMIAVGAFHN-LALSVDR-ILWAWGN---NEYGQLGIGDTQPRSQPIRVEGL 586
           RVQGL  V  +    +    A+  DR   ++WG    N  G++   +  PR +P  + G 
Sbjct: 52  RVQGLTNVVPVVDDNYKRPYAVWKDRGYAYSWGQQIRNYLGRVVNTNQYPRDRPGALTGK 111

Query: 585 SNLSLVDIAAGGWHSAALTKEGEVYAWG 502
              S + +  GG+    L + G +Y  G
Sbjct: 112 DVRSTIQVQVGGYGMYLLNENGNLYVTG 139

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>UNC5B_HUMAN (Q8IZJ1) Netrin receptor UNC5B precursor (Unc-5 homolog B) (Unc-5|
           homolog 2) (p53-regulated receptor for death and life
           protein 1)
          Length = 945

 Score = 33.9 bits (76), Expect = 0.55
 Identities = 18/54 (33%), Positives = 25/54 (46%)
 Frame = +3

Query: 339 PSRKRISGRHWLAQLNGSLHMIPEQYPLQLEAEPVVAPCGCSYHPQSRASHVLL 500
           P    +S R W+ QL    H    +  + L+ E +  PC C   P  RA H+LL
Sbjct: 623 PHCAEVSARDWIFQLKTQAHQGHWEEVVTLDEETLNTPCYCQLEP--RACHILL 674

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>TKT_SCHPO (Q9URM2) Probable transketolase (EC 2.2.1.1) (TK)|
          Length = 685

 Score = 32.3 bits (72), Expect = 1.6
 Identities = 22/70 (31%), Positives = 31/70 (44%)
 Frame = -3

Query: 663 WGNNEYGQLGIGDTQPRSQPIRVEGLSNLSLVDIAAGGWHSAALTKEGEVYAWGRGEHGR 484
           +G  E+G  GI +      PI   G + L+ V  AAG    AAL     +Y      H  
Sbjct: 418 YGIREHGMAGIMNGLAVYGPIIPYGGTFLNFVSYAAGAVRMAALNNSRVIYV---ATHDS 474

Query: 483 LGFGDDKSSH 454
           +G G+D  +H
Sbjct: 475 IGLGEDGPTH 484


  Database: uniprot_sprot.fasta
    Posted date:  May 25, 2006  5:36 PM
  Number of letters in database: 80,573,946
  Number of sequences in database:  219,361
  
Lambda     K      H
   0.318    0.135    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 119,379,894
Number of Sequences: 219361
Number of extensions: 2707901
Number of successful extensions: 7218
Number of sequences better than 10.0: 53
Number of HSP's better than 10.0 without gapping: 6461
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 6939
length of database: 80,573,946
effective HSP length: 110
effective length of database: 56,444,236
effective search space used: 7902193040
frameshift window, decay const: 50,  0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)

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full-length cDNA and EST

Clone Information

BLAST Search Result