ナショナルバイオリソースプロジェクト
-Barley Genetic Resources Database-
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| Clone Name | rbags32c09 |
|---|---|
| Clone Library Name | barley_pub |
>HEM3_PEA (Q43082) Porphobilinogen deaminase, chloroplast precursor (EC| 2.5.1.61) (PBG) (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 369 Score = 209 bits (531), Expect = 7e-54 Identities = 98/133 (73%), Positives = 117/133 (87%) Frame = -2 Query: 620 KRLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREF 441 KRL+M E TS LS+D+MLPAVAQGAIGIACRSNDDKM EYL+SLNHE+TRLA++CER F Sbjct: 236 KRLNMTENVTSTLSIDDMLPAVAQGAIGIACRSNDDKMAEYLASLNHEETRLAISCERAF 295 Query: 440 LSVLDGNCRTPIAAYAYRDKDGNCSFRGLLASPDGSIVYETSRSGTYSFDDMVAIGQDAG 261 L+ LDG+CRTPIA YA RDKDGNC FRGL+ASPDG+ V ETSR G+Y+++DM+ IG+DAG Sbjct: 296 LTTLDGSCRTPIAGYASRDKDGNCLFRGLVASPDGTRVLETSRIGSYTYEDMMKIGKDAG 355 Query: 260 HELKSKAGPGFFD 222 EL S+AGPGFF+ Sbjct: 356 EELLSRAGPGFFN 368
>HEM3_ARATH (Q43316) Porphobilinogen deaminase, chloroplast precursor (EC| 2.5.1.61) (PBG) (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 382 Score = 196 bits (498), Expect = 5e-50 Identities = 92/132 (69%), Positives = 111/132 (84%) Frame = -2 Query: 620 KRLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREF 441 KRL M E S+LS+DEMLPAVAQGAIGIACR++DDKM YL+SLNHE+TRLA++CER F Sbjct: 249 KRLSMTENVASILSLDEMLPAVAQGAIGIACRTDDDKMATYLASLNHEETRLAISCERAF 308 Query: 440 LSVLDGNCRTPIAAYAYRDKDGNCSFRGLLASPDGSIVYETSRSGTYSFDDMVAIGQDAG 261 L LDG+CRTPIA YA +D++GNC FRGL+ASPDG+ V ETSR G Y ++DMV +G+DAG Sbjct: 309 LETLDGSCRTPIAGYASKDEEGNCIFRGLVASPDGTKVLETSRKGPYVYEDMVKMGKDAG 368 Query: 260 HELKSKAGPGFF 225 EL S+AGPGFF Sbjct: 369 QELLSRAGPGFF 380
>HEM3_BRUME (Q8YJB0) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 314 Score = 114 bits (284), Expect = 3e-25 Identities = 61/136 (44%), Positives = 84/136 (61%) Frame = -2 Query: 620 KRLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREF 441 +RL +A+ T VL PA QGAIGI R D+++ L+ L H +T++A+ACER F Sbjct: 182 RRLGLADVITDVLDPSVFPPAPGQGAIGIESRIGDERIDVLLAPLAHRETQIALACERAF 241 Query: 440 LSVLDGNCRTPIAAYAYRDKDGNCSFRGLLASPDGSIVYETSRSGTYSFDDMVAIGQDAG 261 L LDG+CRTPIA A + D SFRG++ +PDG +E + G S D A+G DA Sbjct: 242 LGALDGSCRTPIAGLATVEGD-RLSFRGMILTPDGRQAHEVTAEGVVS--DAAALGTDAA 298 Query: 260 HELKSKAGPGFFDGLQ 213 + +++ AGP FFDG Q Sbjct: 299 NRVRAMAGPHFFDGWQ 314
>HEM3_BRUSU (Q8FYI6) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 314 Score = 112 bits (281), Expect = 7e-25 Identities = 60/136 (44%), Positives = 84/136 (61%) Frame = -2 Query: 620 KRLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREF 441 +RL +A+ T +L PA QGAIGI R D+++ L+ L H +T++A+ACER F Sbjct: 182 RRLGLADVITDLLDPSVFPPAPGQGAIGIESRIGDERIDVLLAPLAHRETQIALACERAF 241 Query: 440 LSVLDGNCRTPIAAYAYRDKDGNCSFRGLLASPDGSIVYETSRSGTYSFDDMVAIGQDAG 261 L LDG+CRTPIA A + D SFRG++ +PDG +E + G S D A+G DA Sbjct: 242 LGALDGSCRTPIAGLATVEGD-RLSFRGMILTPDGRQAHEVTAEGVVS--DAAALGTDAA 298 Query: 260 HELKSKAGPGFFDGLQ 213 + +++ AGP FFDG Q Sbjct: 299 NRVRAMAGPHFFDGWQ 314
>HEM3_AGRT5 (Q8UC46) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 309 Score = 104 bits (260), Expect = 2e-22 Identities = 59/134 (44%), Positives = 78/134 (58%) Frame = -2 Query: 620 KRLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREF 441 KRL T +L E PA AQGAIG+ R D +M + L+ +N T AV CER F Sbjct: 177 KRLGKDNVPTEILDPKEFPPAPAQGAIGVESRIGDARMDKLLAPINDRPTYDAVTCERAF 236 Query: 440 LSVLDGNCRTPIAAYAYRDKDGNCSFRGLLASPDGSIVYETSRSGTYSFDDMVAIGQDAG 261 L+ LDG+CRTPIA YA + D N F GL+ +PDG + SG D + +G+ AG Sbjct: 237 LAALDGSCRTPIAGYATCEGD-NLHFSGLILTPDGQTSHGVEISGNRR--DALILGKKAG 293 Query: 260 HELKSKAGPGFFDG 219 E+++KAG FF+G Sbjct: 294 EEVRAKAGSNFFEG 307
>HEM3_RHIME (Q92LH7) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 309 Score = 103 bits (258), Expect = 3e-22 Identities = 55/132 (41%), Positives = 81/132 (61%) Frame = -2 Query: 620 KRLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREF 441 +RL M T +L +E PA AQGAI + R DD++ L++++ T AV+CER F Sbjct: 177 RRLGMEHVPTELLDPEEFPPAPAQGAICVEARIGDDRINTLLAAIDDPRTHEAVSCERGF 236 Query: 440 LSVLDGNCRTPIAAYAYRDKDGNCSFRGLLASPDGSIVYETSRSGTYSFDDMVAIGQDAG 261 L+ LDG+CRTPIA YA D + F G++ +PDG+ ++ G + D +GQ+AG Sbjct: 237 LATLDGSCRTPIAGYAQSD-GTHIRFAGMILTPDGTTSHQIEIDGRAA--DAERLGQEAG 293 Query: 260 HELKSKAGPGFF 225 +++KAGPGFF Sbjct: 294 ERIRAKAGPGFF 305
>HEM3_RHILO (Q98EI7) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 308 Score = 99.4 bits (246), Expect = 8e-21 Identities = 57/134 (42%), Positives = 78/134 (58%) Frame = -2 Query: 620 KRLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREF 441 KRL + AT ++ +D PA QGAIGI R D + + L +++ T A+ACER F Sbjct: 176 KRLGLEHVATDLMPLDIFPPAPGQGAIGIETRIGDRAVEKMLVAIHDVPTGQALACERAF 235 Query: 440 LSVLDGNCRTPIAAYAYRDKDGNCSFRGLLASPDGSIVYETSRSGTYSFDDMVAIGQDAG 261 L+ LDG+CRTPIA +A + GN SF GL+ SPDG+ + G D IG +A Sbjct: 236 LAALDGSCRTPIAGHA-TIETGNLSFAGLIISPDGTQSHTVELQG--PAQDAARIGDEAA 292 Query: 260 HELKSKAGPGFFDG 219 +++KAG FFDG Sbjct: 293 RTVRAKAGEKFFDG 306
>HEM3_STAES (Q8CNY8) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 308 Score = 92.8 bits (229), Expect = 7e-19 Identities = 48/117 (41%), Positives = 69/117 (58%) Frame = -2 Query: 593 TSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREFLSVLDGNCR 414 T+ L D +LPA+ QGA+GI CRS+D ++++ LS +++ D V ER FLS +DG+C+ Sbjct: 183 TTYLDRDILLPAIGQGALGIECRSDDKELLDLLSKVHNHDVAQCVTAERTFLSEMDGSCQ 242 Query: 413 TPIAAYAYRDKDGNCSFRGLLASPDGSIVYETSRSGTYSFDDMVAIGQDAGHELKSK 243 PI YA +D F GL+ SPDG YE + GT D V +G + LK + Sbjct: 243 VPIGGYATIAQDNQIEFTGLIMSPDGKERYEHTALGT----DPVKLGIEVSQVLKKQ 295
>HEM3_STAEQ (Q5HNN3) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 308 Score = 92.8 bits (229), Expect = 7e-19 Identities = 48/117 (41%), Positives = 69/117 (58%) Frame = -2 Query: 593 TSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREFLSVLDGNCR 414 T+ L D +LPA+ QGA+GI CRS+D ++++ LS +++ D V ER FLS +DG+C+ Sbjct: 183 TTYLDRDILLPAIGQGALGIECRSDDKELLDLLSKVHNHDVAQCVTAERTFLSEMDGSCQ 242 Query: 413 TPIAAYAYRDKDGNCSFRGLLASPDGSIVYETSRSGTYSFDDMVAIGQDAGHELKSK 243 PI YA +D F GL+ SPDG YE + GT D V +G + LK + Sbjct: 243 VPIGGYATIAQDNQIEFTGLIMSPDGKERYEHTALGT----DPVKLGIEVSQVLKKQ 295
>HEM3_STAAU (O34090) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 308 Score = 92.8 bits (229), Expect = 7e-19 Identities = 45/120 (37%), Positives = 73/120 (60%) Frame = -2 Query: 602 ETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREFLSVLDG 423 + TS L D +LPA+ QGA+GI CRS+D++++ LS +++++ V ER FL+ +DG Sbjct: 180 DIVTSYLDRDTLLPAIGQGALGIECRSDDEELLTLLSKVHNDEVAKCVTAERTFLAEMDG 239 Query: 422 NCRTPIAAYAYRDKDGNCSFRGLLASPDGSIVYETSRSGTYSFDDMVAIGQDAGHELKSK 243 +C+ PIA YA F GL+ +PDG +E + +GT D V +G+ ++LK + Sbjct: 240 SCQVPIAGYATISDQNEIEFTGLIMTPDGKERFEYTMNGT----DPVELGKTVSNKLKEQ 295
>HEM3_STAAC (Q5HFA2) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 308 Score = 92.8 bits (229), Expect = 7e-19 Identities = 45/120 (37%), Positives = 73/120 (60%) Frame = -2 Query: 602 ETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREFLSVLDG 423 + TS L D +LPA+ QGA+GI CRS+D++++ LS +++++ V ER FL+ +DG Sbjct: 180 DIVTSYLDRDTLLPAIGQGALGIECRSDDEELLTLLSKVHNDEVAKCVTAERTFLAEMDG 239 Query: 422 NCRTPIAAYAYRDKDGNCSFRGLLASPDGSIVYETSRSGTYSFDDMVAIGQDAGHELKSK 243 +C+ PIA YA F GL+ +PDG +E + +GT D V +G+ ++LK + Sbjct: 240 SCQVPIAGYATISDQNEIEFTGLIMTPDGKERFEYTMNGT----DPVELGKTVSNKLKEQ 295
>HEM3_STAAW (Q8NW74) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 308 Score = 92.0 bits (227), Expect = 1e-18 Identities = 45/120 (37%), Positives = 73/120 (60%) Frame = -2 Query: 602 ETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREFLSVLDG 423 + TS L D +LPA+ QGA+GI CRS+D++++ LS +++++ V ER FL+ +DG Sbjct: 180 DIVTSYLDRDTLLPAIGQGALGIECRSDDEELLTLLSKVHNDEVAKCVTAERTFLAEMDG 239 Query: 422 NCRTPIAAYAYRDKDGNCSFRGLLASPDGSIVYETSRSGTYSFDDMVAIGQDAGHELKSK 243 +C+ PIA YA F GL+ +PDG +E + +GT D V +G+ ++LK + Sbjct: 240 SCQVPIAGYATISDQKEIEFTGLIMTPDGKERFEYTMNGT----DPVELGKTVSNKLKEQ 295
>HEM3_STAAS (Q6G8Q5) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 308 Score = 92.0 bits (227), Expect = 1e-18 Identities = 45/120 (37%), Positives = 73/120 (60%) Frame = -2 Query: 602 ETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREFLSVLDG 423 + TS L D +LPA+ QGA+GI CRS+D++++ LS +++++ V ER FL+ +DG Sbjct: 180 DIVTSYLDRDTLLPAIGQGALGIECRSDDEELLTLLSKVHNDEVAKCVTAERTFLAEMDG 239 Query: 422 NCRTPIAAYAYRDKDGNCSFRGLLASPDGSIVYETSRSGTYSFDDMVAIGQDAGHELKSK 243 +C+ PIA YA F GL+ +PDG +E + +GT D V +G+ ++LK + Sbjct: 240 SCQVPIAGYATISDQKEIEFTGLIMTPDGKERFEYTMNGT----DPVELGKTVSNKLKEQ 295
>HEM3_STAAR (Q6GG35) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 308 Score = 92.0 bits (227), Expect = 1e-18 Identities = 45/120 (37%), Positives = 73/120 (60%) Frame = -2 Query: 602 ETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREFLSVLDG 423 + TS L D +LPA+ QGA+GI CRS+D++++ LS +++++ V ER FL+ +DG Sbjct: 180 DIVTSYLDRDTLLPAIGQGALGIECRSDDEELLTLLSKVHNDEVAKCVTAERTFLAEMDG 239 Query: 422 NCRTPIAAYAYRDKDGNCSFRGLLASPDGSIVYETSRSGTYSFDDMVAIGQDAGHELKSK 243 +C+ PIA YA F GL+ +PDG +E + +GT D V +G+ ++LK + Sbjct: 240 SCQVPIAGYATISDQKEIEFTGLIMTPDGKERFEYTMNGT----DPVELGKKVSNKLKEQ 295
>HEM3_STAAN (P64341) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 308 Score = 92.0 bits (227), Expect = 1e-18 Identities = 45/120 (37%), Positives = 73/120 (60%) Frame = -2 Query: 602 ETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREFLSVLDG 423 + TS L D +LPA+ QGA+GI CRS+D++++ LS +++++ V ER FL+ +DG Sbjct: 180 DIVTSYLDRDTLLPAIGQGALGIECRSDDEELLTLLSKVHNDEVAKCVTAERTFLAEMDG 239 Query: 422 NCRTPIAAYAYRDKDGNCSFRGLLASPDGSIVYETSRSGTYSFDDMVAIGQDAGHELKSK 243 +C+ PIA YA F GL+ +PDG +E + +GT D V +G+ ++LK + Sbjct: 240 SCQVPIAGYATISDQKEIEFTGLIMTPDGKERFEYTMNGT----DPVELGKTVSNKLKEQ 295
>HEM3_STAAM (P64340) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 308 Score = 92.0 bits (227), Expect = 1e-18 Identities = 45/120 (37%), Positives = 73/120 (60%) Frame = -2 Query: 602 ETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREFLSVLDG 423 + TS L D +LPA+ QGA+GI CRS+D++++ LS +++++ V ER FL+ +DG Sbjct: 180 DIVTSYLDRDTLLPAIGQGALGIECRSDDEELLTLLSKVHNDEVAKCVTAERTFLAEMDG 239 Query: 422 NCRTPIAAYAYRDKDGNCSFRGLLASPDGSIVYETSRSGTYSFDDMVAIGQDAGHELKSK 243 +C+ PIA YA F GL+ +PDG +E + +GT D V +G+ ++LK + Sbjct: 240 SCQVPIAGYATISDQKEIEFTGLIMTPDGKERFEYTMNGT----DPVELGKTVSNKLKEQ 295
>HEM3_SHEON (Q8E9H0) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 310 Score = 88.6 bits (218), Expect = 1e-17 Identities = 50/134 (37%), Positives = 74/134 (55%) Frame = -2 Query: 617 RLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREFL 438 RL ++E S +S +E LPA QGA+GI CR+ND+++ L+ L H +TR V ER Sbjct: 176 RLKLSERIASFISAEESLPANGQGAVGIECRTNDERVKALLAPLEHLETRYRVIAERAMN 235 Query: 437 SVLDGNCRTPIAAYAYRDKDGNCSFRGLLASPDGSIVYETSRSGTYSFDDMVAIGQDAGH 258 + L+G C+ PI A+A D D + RGL+ +PDGS + E +G + + +G Sbjct: 236 TRLEGGCQVPIGAFAEIDGD-EMTLRGLVGNPDGSEIIEGVITGPKT--EATQLGVALAE 292 Query: 257 ELKSKAGPGFFDGL 216 EL SK D + Sbjct: 293 ELLSKGAKSILDAV 306
>HEM3_ERWCT (Q6CZG3) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 313 Score = 87.0 bits (214), Expect = 4e-17 Identities = 53/126 (42%), Positives = 69/126 (54%) Frame = -2 Query: 620 KRLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREF 441 KRL + E LS +E LPAV QGAIGI CR +DD++ + L+ LNH DT V ER Sbjct: 175 KRLGLEERIRCALSPEESLPAVGQGAIGIECRLDDDRIRQLLAPLNHTDTAARVLAERAM 234 Query: 440 LSVLDGNCRTPIAAYAYRDKDGNCSFRGLLASPDGSIVYETSRSGTYSFDDMVAIGQDAG 261 L+G C+ PI +YA + D R L+ +PDGS + R G+ S D IG Sbjct: 235 NVRLEGGCQVPIGSYAELEGD-TLWLRALVGAPDGSQMIVGERKGSVS--DAEKIGVALA 291 Query: 260 HELKSK 243 EL +K Sbjct: 292 EELLAK 297
>HEM3_VIBVY (Q7MQC7) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 312 Score = 85.1 bits (209), Expect = 1e-16 Identities = 42/96 (43%), Positives = 58/96 (60%) Frame = -2 Query: 620 KRLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREF 441 KRL + E S + ++ LPAV QGA+GI CR+ND+++++ L LNH DT V CER Sbjct: 176 KRLELEERIRSFIEPEQSLPAVGQGAVGIECRTNDERILKLLEPLNHADTADRVKCERAM 235 Query: 440 LSVLDGNCRTPIAAYAYRDKDGNCSFRGLLASPDGS 333 L+G C+ PI +YA + D R L+ PDGS Sbjct: 236 NLTLEGGCQVPIGSYALLEGD-EIWLRALVGEPDGS 270
>HEM3_VIBVU (Q8DD85) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 312 Score = 85.1 bits (209), Expect = 1e-16 Identities = 42/96 (43%), Positives = 58/96 (60%) Frame = -2 Query: 620 KRLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREF 441 KRL + E S + ++ LPAV QGA+GI CR+ND+++++ L LNH DT V CER Sbjct: 176 KRLELEERIRSFIEPEQSLPAVGQGAVGIECRTNDERILKLLEPLNHADTADRVKCERAM 235 Query: 440 LSVLDGNCRTPIAAYAYRDKDGNCSFRGLLASPDGS 333 L+G C+ PI +YA + D R L+ PDGS Sbjct: 236 NLTLEGGCQVPIGSYALLEGD-EIWLRALVGEPDGS 270
>HEM3_GEOKA (Q5KWK6) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 309 Score = 84.7 bits (208), Expect = 2e-16 Identities = 46/127 (36%), Positives = 68/127 (53%) Frame = -2 Query: 602 ETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREFLSVLDG 423 + + L D +PAV QGA+ + CR +DD++ ++LS LN E T AV ER FL ++G Sbjct: 180 DVISDYLPFDVCVPAVGQGALAVECREDDDELRQWLSRLNDEQTERAVRAERAFLQQMEG 239 Query: 422 NCRTPIAAYAYRDKDGNCSFRGLLASPDGSIVYETSRSGTYSFDDMVAIGQDAGHELKSK 243 C+ PIA YA K+G L+ASPDG +Y+ +G D A+G+ A L + Sbjct: 240 GCQVPIAGYA-EVKEGTVRLTALVASPDGKEMYKEIVTGA----DPEAVGRQAAAILSEQ 294 Query: 242 AGPGFFD 222 + Sbjct: 295 GAKALIE 301
>HEM3_CHRVO (Q7P207) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 309 Score = 84.0 bits (206), Expect = 3e-16 Identities = 49/123 (39%), Positives = 67/123 (54%) Frame = -2 Query: 620 KRLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREF 441 KRL +AE L+ E LPA QGA+GI R++ + L+ LNH DTR A ER Sbjct: 173 KRLGLAERIQGELAPSESLPAAGQGALGIEIRADRADLSALLAPLNHPDTRACTAAERAL 232 Query: 440 LSVLDGNCRTPIAAYAYRDKDGNCSFRGLLASPDGSIVYETSRSGTYSFDDMVAIGQDAG 261 L G+C+ P+ A+A DG + GL+A PDGS+V S SG + D A+G+ Sbjct: 233 AKELGGSCQVPLGAFATL-ADGTLTLGGLVAHPDGSVVLTASASGPADYAD--ALGRAVA 289 Query: 260 HEL 252 +L Sbjct: 290 KKL 292
>HEM3_GLOVI (Q7NGF7) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 328 Score = 84.0 bits (206), Expect = 3e-16 Identities = 48/133 (36%), Positives = 68/133 (51%) Frame = -2 Query: 620 KRLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREF 441 +RL +E + VLS D L AV QGA+GI CR D ++++ L+ LNH T ER Sbjct: 178 RRLGWSERISEVLSPDISLHAVGQGALGIECREADGEILDLLTVLNHPPTARRCRAERAM 237 Query: 440 LSVLDGNCRTPIAAYAYRDKDGNCSFRGLLASPDGSIVYETSRSGTYSFDDMVAIGQDAG 261 L L+G C+ PI Y D G + +G++AS DG + RSG D A+G+ Sbjct: 238 LRALEGGCQVPIGVYTELDDSGRLTLQGIVASLDGRNMARACRSG--PGDAPEALGRAVA 295 Query: 260 HELKSKAGPGFFD 222 +LK+ D Sbjct: 296 EDLKAAGAQAILD 308
>HEM3_PHOLL (Q7MYN1) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 313 Score = 83.6 bits (205), Expect = 4e-16 Identities = 42/104 (40%), Positives = 62/104 (59%) Frame = -2 Query: 620 KRLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREF 441 KRL + E + L+ ++ LPAV QGA+GI CR +D + L+ LNH DT + V ER Sbjct: 175 KRLKLHERIRTPLTAEQSLPAVGQGAVGIECRLDDQQTQTLLAPLNHYDTEVCVLAERAM 234 Query: 440 LSVLDGNCRTPIAAYAYRDKDGNCSFRGLLASPDGSIVYETSRS 309 + L+G C+ PI +YA +DG R L+ +PDGS++ R+ Sbjct: 235 NTRLEGGCQVPIGSYAIW-QDGKIWLRALVGAPDGSVIIRGERT 277
>HEM3_BACSK (Q5WEP5) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 311 Score = 83.2 bits (204), Expect = 6e-16 Identities = 44/106 (41%), Positives = 60/106 (56%), Gaps = 1/106 (0%) Frame = -2 Query: 620 KRLHMAETA-TSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACERE 444 KRL E T L D LPA+ QGA+G+ CR +D + E L+ L+HE+T AV ER Sbjct: 173 KRLGYGEDVITEYLDKDVCLPAIGQGALGLECRVDDVETTELLAKLHHEETGKAVLAERA 232 Query: 443 FLSVLDGNCRTPIAAYAYRDKDGNCSFRGLLASPDGSIVYETSRSG 306 FL ++G C+ PI YA +DG GL+ SPDG + + + G Sbjct: 233 FLKEMNGGCQVPIGGYATVLEDGAVFLTGLVGSPDGKTILKEGKCG 278
>HEM3_LISIN (Q92BF8) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 309 Score = 83.2 bits (204), Expect = 6e-16 Identities = 45/114 (39%), Positives = 67/114 (58%) Frame = -2 Query: 584 LSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREFLSVLDGNCRTPI 405 +S + LPAV QGA+ I CR D ++ + L+S++HE+T + V ER FL L+G C PI Sbjct: 189 ISPELCLPAVGQGALAIECRETDLQICDMLASIHHEETGICVEAERVFLKKLNGGCEIPI 248 Query: 404 AAYAYRDKDGNCSFRGLLASPDGSIVYETSRSGTYSFDDMVAIGQDAGHELKSK 243 A +A + D + F+GL+ + DGSI+ E+ R+G IG EL S+ Sbjct: 249 AGFATKTGD-SVHFKGLVGNADGSIILESERTGA----SPAEIGNQVAEELLSE 297
>HEM3_PAEMA (O69110) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 324 Score = 82.8 bits (203), Expect = 7e-16 Identities = 53/147 (36%), Positives = 72/147 (48%), Gaps = 19/147 (12%) Frame = -2 Query: 620 KRLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREF 441 +R+ T+ LS D LPAV QGA+GI CR ND ++ + LS N DT L VA ER F Sbjct: 179 QRMGWENRVTAYLSADVCLPAVGQGALGIECRENDAELRDVLSLYNDPDTALTVAAERRF 238 Query: 440 LSVLDGNCRTPIAAYAYRDKDG-------------------NCSFRGLLASPDGSIVYET 318 L+VL+G C+ PIAAYA ++ G G++ S DG +E Sbjct: 239 LAVLNGGCQVPIAAYANLERAGGQAPEEGGRAAASQAPAALRIRLTGMVGSADGRGYFE- 297 Query: 317 SRSGTYSFDDMVAIGQDAGHELKSKAG 237 G +D VA G+ L ++ G Sbjct: 298 ---GECRREDPVAFGERIAGLLLAQGG 321
>HEM3_VIBPA (Q87KI9) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 312 Score = 82.0 bits (201), Expect = 1e-15 Identities = 46/123 (37%), Positives = 67/123 (54%) Frame = -2 Query: 620 KRLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREF 441 KRL + + S + ++ LPAV QGA+GI CR +D+++++ L LNH+DT V CER Sbjct: 176 KRLKLEDRIRSFIEPEQSLPAVGQGAVGIECRVDDERLLKLLEPLNHKDTADRVLCERAM 235 Query: 440 LSVLDGNCRTPIAAYAYRDKDGNCSFRGLLASPDGSIVYETSRSGTYSFDDMVAIGQDAG 261 L+G C+ PI +YA + D R L+ PDGS + G D A+G Sbjct: 236 NLTLEGGCQVPIGSYALLEGD-EIWLRALVGEPDGSEIVRGEVRGHRK--DGEALGIQLA 292 Query: 260 HEL 252 +EL Sbjct: 293 NEL 295
>HEM3_BACHD (Q9K8G0) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 311 Score = 81.6 bits (200), Expect = 2e-15 Identities = 42/117 (35%), Positives = 63/117 (53%) Frame = -2 Query: 602 ETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREFLSVLDG 423 E T L D +PAV QGA+GI CR++DD+++E L ++N + T V ER FL ++G Sbjct: 180 EIVTEYLDPDLCVPAVGQGALGIECRADDDEVLEMLKTINDDTTAKTVLAERTFLHRMEG 239 Query: 422 NCRTPIAAYAYRDKDGNCSFRGLLASPDGSIVYETSRSGTYSFDDMVAIGQDAGHEL 252 C+ PIA YA +G L+ +PDG +++ G D V +G+ L Sbjct: 240 GCQVPIAGYATLTDEGEIELTALVGTPDGEQIFKEILRG----KDPVQLGETMAQAL 292
>HEM3_IDILO (Q5QUS3) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 313 Score = 80.5 bits (197), Expect = 4e-15 Identities = 45/107 (42%), Positives = 59/107 (55%) Frame = -2 Query: 617 RLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREFL 438 RL + + TS + V++ LPA QGA+GI CRS+DD+M L+ L ++TR V ER Sbjct: 175 RLELGDRITSFIPVEQSLPANGQGALGIECRSDDDEMKALLAPLQCQETRTRVLAERAMN 234 Query: 437 SVLDGNCRTPIAAYAYRDKDGNCSFRGLLASPDGSIVYETSRSGTYS 297 LDG C+ PI AYA + D RGL+ PDG V G S Sbjct: 235 RGLDGGCQVPIGAYAELEGD-EVYLRGLVGEPDGGKVLRDEVRGPAS 280
>HEM3_PROMI (Q59684) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 313 Score = 80.1 bits (196), Expect = 5e-15 Identities = 48/126 (38%), Positives = 63/126 (50%) Frame = -2 Query: 620 KRLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREF 441 KRL + E S LS ++ LPAV QGA+GI CR +D L++LNH DT V ER Sbjct: 175 KRLKLTERIRSSLSAEQSLPAVGQGAVGIECRLDDHDTQALLAALNHADTATCVKAERAM 234 Query: 440 LSVLDGNCRTPIAAYAYRDKDGNCSFRGLLASPDGSIVYETSRSGTYSFDDMVAIGQDAG 261 + L+G C+ PI +YA D R L+ +PDG + R S +D G Sbjct: 235 NTRLEGGCQVPIGSYAIWQND-KIWLRALVGAPDGKTILRGER--LVSPEDAEQAGISLA 291 Query: 260 HELKSK 243 EL K Sbjct: 292 EELLDK 297
>HEM3_BACSU (P16616) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 313 Score = 80.1 bits (196), Expect = 5e-15 Identities = 36/99 (36%), Positives = 57/99 (57%) Frame = -2 Query: 602 ETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREFLSVLDG 423 + T L + LPAV QGA+ I CR +D++++ S E T+ V ER FL+ ++G Sbjct: 180 DVVTEFLEPERCLPAVGQGALAIECRESDEELLALFSQFTDEYTKRTVLAERAFLNAMEG 239 Query: 422 NCRTPIAAYAYRDKDGNCSFRGLLASPDGSIVYETSRSG 306 C+ PIA Y+ + GL+ASPDG I+++ + +G Sbjct: 240 GCQVPIAGYSVLNGQDEIEMTGLVASPDGKIIFKETVTG 278
>HEM3_ECOLI (P06983) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 313 Score = 79.7 bits (195), Expect = 6e-15 Identities = 43/105 (40%), Positives = 59/105 (56%) Frame = -2 Query: 620 KRLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREF 441 KRL + + L + LPAV QGA+GI CR +D + E L++LNH +T L V ER Sbjct: 175 KRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRELLAALNHHETALRVTAERAM 234 Query: 440 LSVLDGNCRTPIAAYAYRDKDGNCSFRGLLASPDGSIVYETSRSG 306 + L+G C+ PI +YA DG R L+ +PDGS + R G Sbjct: 235 NTRLEGGCQVPIGSYA-ELIDGEIWLRALVGAPDGSQIIRGERRG 278
>HEM3_PSESM (Q88B91) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 313 Score = 79.3 bits (194), Expect = 8e-15 Identities = 42/97 (43%), Positives = 58/97 (59%) Frame = -2 Query: 617 RLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREFL 438 RL + TS +SVD+ LPA QGA+GI CRS D ++ L+ L+HEDT + V ER Sbjct: 176 RLGFEDRITSAISVDDSLPAGGQGAVGIECRSVDAEIHALLAPLHHEDTAVRVIAERSLN 235 Query: 437 SVLDGNCRTPIAAYAYRDKDGNCSFRGLLASPDGSIV 327 L+G C+ PIA YA + D + RGL+ P G ++ Sbjct: 236 KHLNGGCQVPIACYAVLEGD-DVWLRGLVGDPSGRVL 271
>HEM3_ECO57 (Q8XAP3) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 313 Score = 79.3 bits (194), Expect = 8e-15 Identities = 43/105 (40%), Positives = 59/105 (56%) Frame = -2 Query: 620 KRLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREF 441 KRL + + L + LPAV QGA+GI CR +D + E L++LNH +T L V ER Sbjct: 175 KRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDTRTRELLAALNHHETALRVTAERAM 234 Query: 440 LSVLDGNCRTPIAAYAYRDKDGNCSFRGLLASPDGSIVYETSRSG 306 + L+G C+ PI +YA DG R L+ +PDGS + R G Sbjct: 235 NTRLEGGCQVPIGSYA-ELIDGEIWLRALVGAPDGSQIIRGERRG 278
>HEM3_VIBCH (Q9KVM1) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 311 Score = 79.0 bits (193), Expect = 1e-14 Identities = 41/96 (42%), Positives = 53/96 (55%) Frame = -2 Query: 620 KRLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREF 441 KRL + S + ++ LPAV QGA+GI CR ND ++ L+ LNH DT V CER Sbjct: 175 KRLELESRIRSFIEPEQSLPAVGQGAVGIECRVNDQRVRALLAPLNHADTADRVRCERAM 234 Query: 440 LSVLDGNCRTPIAAYAYRDKDGNCSFRGLLASPDGS 333 L G C+ PI +YA + D R L+ PDGS Sbjct: 235 NLTLQGGCQVPIGSYALLEGD-TIWLRALVGEPDGS 269
>HEM3_YERPE (P46355) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 313 Score = 79.0 bits (193), Expect = 1e-14 Identities = 43/105 (40%), Positives = 57/105 (54%) Frame = -2 Query: 620 KRLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREF 441 KRL + +S +E LPAV QGA+GI CR +DD + L+ LNH T L V ER Sbjct: 175 KRLGLENRIRYAMSAEESLPAVGQGAVGIECRLDDDHTRQLLAPLNHRHTELRVCAERAM 234 Query: 440 LSVLDGNCRTPIAAYAYRDKDGNCSFRGLLASPDGSIVYETSRSG 306 L+G C+ PI +YA + D R L+ +PDGS + R G Sbjct: 235 NIRLEGGCQVPIGSYAELEGD-TLWLRALVGAPDGSQMIRGERRG 278
>HEM3_ECOL6 (Q8FBP1) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 313 Score = 79.0 bits (193), Expect = 1e-14 Identities = 43/105 (40%), Positives = 59/105 (56%) Frame = -2 Query: 620 KRLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREF 441 KRL + + L + LPAV QGA+GI CR +D + E L++LNH +T L V ER Sbjct: 175 KRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDARTRELLAALNHHETALRVTAERAM 234 Query: 440 LSVLDGNCRTPIAAYAYRDKDGNCSFRGLLASPDGSIVYETSRSG 306 + L+G C+ PI +YA DG R L+ +PDGS + R G Sbjct: 235 NTRLEGGCQVPIGSYA-ELIDGEIWLRALVGAPDGSQIIRGERRG 278
>HEM3_LISMO (Q8Y6X5) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 309 Score = 79.0 bits (193), Expect = 1e-14 Identities = 38/87 (43%), Positives = 57/87 (65%) Frame = -2 Query: 566 LPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREFLSVLDGNCRTPIAAYAYR 387 LPAV QGA+ I CR +D ++ + L+S++HE+T + V ER FL L+G C PIA +A R Sbjct: 195 LPAVGQGALAIECRESDQQIRDMLTSIHHEETGICVEAERVFLKKLNGGCEIPIAGFATR 254 Query: 386 DKDGNCSFRGLLASPDGSIVYETSRSG 306 + F+GL+ + DGSI+ E+ + G Sbjct: 255 ANE-FVQFKGLVGNADGSIILESEQVG 280
>HEM3_YERPS (Q66G00) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 313 Score = 78.6 bits (192), Expect = 1e-14 Identities = 43/105 (40%), Positives = 57/105 (54%) Frame = -2 Query: 620 KRLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREF 441 KRL + +S +E LPAV QGA+GI CR +DD + L+ LNH T L V ER Sbjct: 175 KRLGLETRIRYAMSAEESLPAVGQGAVGIECRLDDDHTRQLLAPLNHRHTELRVCAERAM 234 Query: 440 LSVLDGNCRTPIAAYAYRDKDGNCSFRGLLASPDGSIVYETSRSG 306 L+G C+ PI +YA + D R L+ +PDGS + R G Sbjct: 235 NIRLEGGCQVPIGSYAELEGD-TLWLRALVGAPDGSQMIRGERRG 278
>HEM3_GEOSL (Q747I1) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 318 Score = 77.8 bits (190), Expect = 2e-14 Identities = 47/129 (36%), Positives = 66/129 (51%), Gaps = 6/129 (4%) Frame = -2 Query: 620 KRLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREF 441 KRL + T L VD LPA+ QGA+G+ CR +D + E + NH DT AV ER Sbjct: 174 KRLGFTDVVTEYLPVDLSLPAIGQGALGLECRLDDQAVRETIDFFNHPDTAHAVRAERAL 233 Query: 440 LSVLDGNCRTPIAAYAYRDKDGNCSFRGLLASPDGSIVYETSRSGTYSFDDMVAIG---- 273 L +G C+ PIAA+ D + + G +AS DG+ + S SG + + + I Sbjct: 234 LWRCEGGCQVPIAAHGQVSGD-SLTLTGFIASVDGTRSVKESISGPVTDCEKLGIALAEK 292 Query: 272 --QDAGHEL 252 D GHE+ Sbjct: 293 LLADGGHEI 301
>HEM3_SALTY (P0A1Q8) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 313 Score = 77.8 bits (190), Expect = 2e-14 Identities = 42/106 (39%), Positives = 58/106 (54%) Frame = -2 Query: 620 KRLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREF 441 KRL + + L D LPAV QGA+GI CR +D + L+ LNH T L V ER Sbjct: 175 KRLGLESRIRTALPPDVSLPAVGQGAVGIECRLDDARTQALLAPLNHSQTALRVTAERAM 234 Query: 440 LSVLDGNCRTPIAAYAYRDKDGNCSFRGLLASPDGSIVYETSRSGT 303 + L+G C+ PI +YA +G R L+ +PDGS++ R G+ Sbjct: 235 NTRLEGGCQVPIGSYA-EIINGEIWLRALVGAPDGSVMVRGERRGS 279
>HEM3_SALTI (P0A1Q9) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 313 Score = 77.8 bits (190), Expect = 2e-14 Identities = 42/106 (39%), Positives = 58/106 (54%) Frame = -2 Query: 620 KRLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREF 441 KRL + + L D LPAV QGA+GI CR +D + L+ LNH T L V ER Sbjct: 175 KRLGLESRIRTALPPDVSLPAVGQGAVGIECRLDDARTQALLAPLNHSQTALRVTAERAM 234 Query: 440 LSVLDGNCRTPIAAYAYRDKDGNCSFRGLLASPDGSIVYETSRSGT 303 + L+G C+ PI +YA +G R L+ +PDGS++ R G+ Sbjct: 235 NTRLEGGCQVPIGSYA-EIINGEIWLRALVGAPDGSVMVRGERRGS 279
>HEM3_PSEAE (Q60169) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 313 Score = 77.4 bits (189), Expect = 3e-14 Identities = 42/95 (44%), Positives = 53/95 (55%) Frame = -2 Query: 617 RLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREFL 438 RL S +SVD+ LPA QGA+GI CR+ D + L L+H DT L V ER Sbjct: 176 RLGFESRIRSSISVDDSLPAGGQGAVGIECRTADSDLHALLEPLHHTDTALRVTAERALN 235 Query: 437 SVLDGNCRTPIAAYAYRDKDGNCSFRGLLASPDGS 333 L+G C+ PIA YA R+ D RGL+ PDG+ Sbjct: 236 KRLNGGCQVPIACYAIREGD-QLWLRGLVGQPDGT 269
>HEM3_LISMF (Q71ZB2) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 309 Score = 77.4 bits (189), Expect = 3e-14 Identities = 37/87 (42%), Positives = 57/87 (65%) Frame = -2 Query: 566 LPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREFLSVLDGNCRTPIAAYAYR 387 LPAV QGA+ I CR +D ++ + L+S++HE+T + V ER FL L+G C PIA +A R Sbjct: 195 LPAVGQGALAIECRESDQQIRDMLTSIHHEETGICVEAERVFLKKLNGGCEIPIAGFATR 254 Query: 386 DKDGNCSFRGLLASPDGSIVYETSRSG 306 + F+GL+ + DGSI+ + ++G Sbjct: 255 ANE-VVHFKGLVGNADGSIILASEQAG 280
>HEM3_METCA (Q602K3) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 322 Score = 76.6 bits (187), Expect = 5e-14 Identities = 42/105 (40%), Positives = 55/105 (52%) Frame = -2 Query: 620 KRLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREF 441 KRL E L+ ++ LPA+ QGAIG+ CRS D + L L+H T V ER Sbjct: 187 KRLGFQERIAETLTPEQCLPAIGQGAIGVECRSTDTRTNALLVPLHHPPTAWCVLAERAM 246 Query: 440 LSVLDGNCRTPIAAYAYRDKDGNCSFRGLLASPDGSIVYETSRSG 306 LDG C+ PIA +A + D S RGL+ +PDGS + G Sbjct: 247 NRRLDGGCQVPIAGFAQLEGD-TLSLRGLVGNPDGSGIIRAEAVG 290
>HEM3_BUCAI (P57651) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 314 Score = 76.6 bits (187), Expect = 5e-14 Identities = 40/107 (37%), Positives = 61/107 (57%) Frame = -2 Query: 617 RLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREFL 438 RL + T ++ + LP+ QGAIGI R +D K++ +LS LNH +T + + ER F Sbjct: 176 RLRLKNRITQIIPAELSLPSCGQGAIGIQSRLHDKKVLFFLSRLNHINTFIEINAERAFC 235 Query: 437 SVLDGNCRTPIAAYAYRDKDGNCSFRGLLASPDGSIVYETSRSGTYS 297 L+ C+ PI +YA K+ RGL+ SP+G I+ + R G Y+ Sbjct: 236 RKLESGCQIPIGSYAILKKN-KIWLRGLVGSPNGKIILKGERIGCYN 281
>HEM3_SHIFL (Q83PH4) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 313 Score = 76.3 bits (186), Expect = 7e-14 Identities = 42/105 (40%), Positives = 58/105 (55%) Frame = -2 Query: 620 KRLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREF 441 KRL + + L + LPAV QGA+GI CR +D + E L++LNH +T L V ER Sbjct: 175 KRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDTRTRELLAALNHHETALRVTAERAM 234 Query: 440 LSVLDGNCRTPIAAYAYRDKDGNCSFRGLLASPDGSIVYETSRSG 306 + L+G C+ PI +YA DG L+ +PDGS + R G Sbjct: 235 NTRLEGGCQVPIGSYA-ELIDGEIWLCALVGAPDGSQIIRGERRG 278
>HEM3_COXBU (Q83A37) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 307 Score = 75.5 bits (184), Expect = 1e-13 Identities = 45/128 (35%), Positives = 65/128 (50%) Frame = -2 Query: 620 KRLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREF 441 KRL + E +PA+ QGAIG+ CRS+D +M L SL+H +TRL V ER Sbjct: 174 KRLGLENRIHYYFDPHEFIPAIGQGAIGVECRSDDHEMQTLLKSLDHRETRLCVTAERAV 233 Query: 440 LSVLDGNCRTPIAAYAYRDKDGNCSFRGLLASPDGSIVYETSRSGTYSFDDMVAIGQDAG 261 L G+C TPIAA+A K+ S +L DG ++ + G + ++ IG Sbjct: 234 NEKLGGDCFTPIAAHAI-IKNDQLSLFAMLGKIDGRVIIRATEIG--NSEEAKRIGFKVA 290 Query: 260 HELKSKAG 237 +L + G Sbjct: 291 SQLLEQGG 298
>HEM3_NITEU (Q82WS2) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 308 Score = 74.7 bits (182), Expect = 2e-13 Identities = 44/125 (35%), Positives = 65/125 (52%) Frame = -2 Query: 620 KRLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREF 441 KRL + + +L + LPAV QGA+GI CR ND M+E++ L+H T V ER Sbjct: 176 KRLELGYRISMLLPPELSLPAVGQGALGIECRDNDPDMVEWMKPLHHAATACCVEAERAM 235 Query: 440 LSVLDGNCRTPIAAYAYRDKDGNCSFRGLLASPDGSIVYETSRSGTYSFDDMVAIGQDAG 261 +L G+C+ P+ +A +D + RG +A+PDGS + G + V GQ Sbjct: 236 SRMLGGSCQVPLGGFAEIFED-VLTLRGFVATPDGSRMIADKLCGKPESGEQV--GQQLA 292 Query: 260 HELKS 246 LK+ Sbjct: 293 QNLKA 297
>HEM3_DESVH (Q72AV0) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 315 Score = 74.3 bits (181), Expect = 3e-13 Identities = 42/106 (39%), Positives = 57/106 (53%) Frame = -2 Query: 620 KRLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREF 441 KRL +A VL+ LPAV QGA+GI R + + + L+ L+H TR+ V ER F Sbjct: 174 KRLGLAAPHHEVLAPPRFLPAVGQGALGIEFREDRADLRDMLAFLDHRPTRIRVEAERGF 233 Query: 440 LSVLDGNCRTPIAAYAYRDKDGNCSFRGLLASPDGSIVYETSRSGT 303 L+ L+G C+ PIA +A D N GL+A G V + GT Sbjct: 234 LAGLEGGCQVPIAGHAVMTGDDNFRIEGLVADLKGERVIRRTLEGT 279
>HEM3_BLOFL (Q7VRM4) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 311 Score = 73.9 bits (180), Expect = 3e-13 Identities = 43/122 (35%), Positives = 63/122 (51%) Frame = -2 Query: 617 RLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREFL 438 RL + + + + E+LPA+ QG I I CR ND + LS L H++T L + ER Sbjct: 177 RLKLTKYIQTYIDPSELLPAMGQGVIAIECRINDINTISLLSPLYHKETSLCIKSERAVT 236 Query: 437 SVLDGNCRTPIAAYAYRDKDGNCSFRGLLASPDGSIVYETSRSGTYSFDDMVAIGQDAGH 258 + L+ CR PIA+YA ++ R L+ PDGSI+ T G S D +G + Sbjct: 237 TYLESYCRLPIASYA-EIQNNQIWLRALIGLPDGSIIIRT--EGIASLDKAEELGLNLAK 293 Query: 257 EL 252 +L Sbjct: 294 DL 295
>HEM3_MANSM (Q65VX7) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 310 Score = 72.8 bits (177), Expect = 8e-13 Identities = 38/95 (40%), Positives = 54/95 (56%) Frame = -2 Query: 617 RLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREFL 438 RL MAE S + D LPA QGA+GI CR +D+ + L+ L H++T + V ER Sbjct: 177 RLGMAERIASFIETDISLPAAGQGAVGIECRVDDELVQSLLAPLAHQETTICVLAERAMN 236 Query: 437 SVLDGNCRTPIAAYAYRDKDGNCSFRGLLASPDGS 333 + L G C+ PI +A + K+G R L+ + DGS Sbjct: 237 NRLQGGCQVPIGGFA-QVKNGEVFLRALVGATDGS 270
>HEM3_PSEPK (Q88RE5) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 313 Score = 72.8 bits (177), Expect = 8e-13 Identities = 41/94 (43%), Positives = 53/94 (56%) Frame = -2 Query: 617 RLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREFL 438 RL + TS +SVD+ LPA QGA+GI CRS D ++ L+ L+H DT V ER Sbjct: 176 RLGFEDRITSTISVDDSLPAGGQGAVGIECRSADVEIHALLAPLHHVDTADRVIAERALN 235 Query: 437 SVLDGNCRTPIAAYAYRDKDGNCSFRGLLASPDG 336 L+G C+ PIA YA + D RGL+ P G Sbjct: 236 KRLNGGCQVPIACYAVLEGD-QLWLRGLVGQPSG 268
>HEM3_NEIMB (Q9K0P6) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 311 Score = 72.4 bits (176), Expect = 1e-12 Identities = 41/123 (33%), Positives = 63/123 (51%) Frame = -2 Query: 620 KRLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREF 441 +RL + +LS + LPA QGA+GI ++ + + E L LNH T V ER Sbjct: 175 QRLKLDGRIRMILSESDSLPAAGQGALGIEIAAHREDLYEVLKPLNHGVTNACVTAERAL 234 Query: 440 LSVLDGNCRTPIAAYAYRDKDGNCSFRGLLASPDGSIVYETSRSGTYSFDDMVAIGQDAG 261 L G+C+ P+AAY +++G + RGL+ PDGS+V + D A+G+ Sbjct: 235 ARALGGSCQVPLAAYC-TEENGLLTLRGLVGHPDGSVVLRADAQAPAEYAD--ALGRAVA 291 Query: 260 HEL 252 +L Sbjct: 292 KKL 294
>HEM3_NEIMA (Q9JVS4) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 311 Score = 72.4 bits (176), Expect = 1e-12 Identities = 41/123 (33%), Positives = 63/123 (51%) Frame = -2 Query: 620 KRLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREF 441 +RL + +LS + LPA QGA+GI ++ + + E L LNH T V ER Sbjct: 175 QRLKLDGRIRMILSESDSLPAAGQGALGIEIAAHREDLYEVLKPLNHGVTNACVTAERAL 234 Query: 440 LSVLDGNCRTPIAAYAYRDKDGNCSFRGLLASPDGSIVYETSRSGTYSFDDMVAIGQDAG 261 L G+C+ P+AAY +++G + RGL+ PDGS+V + D A+G+ Sbjct: 235 ARALGGSCQVPLAAYC-TEENGLLTLRGLVGHPDGSVVLRADAQAPAEYAD--ALGRAVA 291 Query: 260 HEL 252 +L Sbjct: 292 KKL 294
>HEM32_STRCO (Q9KY00) Porphobilinogen deaminase 2 (EC 2.5.1.61) (PBG 2)| (Hydroxymethylbilane synthase 2) (HMBS 2) (Pre-uroporphyrinogen synthase 2) Length = 313 Score = 72.4 bits (176), Expect = 1e-12 Identities = 33/97 (34%), Positives = 53/97 (54%) Frame = -2 Query: 620 KRLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREF 441 +R+ + + VLS + M+P + G + + CR D ++E +S+L T ER F Sbjct: 179 ERIGRTDVISEVLSTETMMPPIGAGILALQCREGDRALIEAVSALGDPRTHREATAERMF 238 Query: 440 LSVLDGNCRTPIAAYAYRDKDGNCSFRGLLASPDGSI 330 L VL G+C +PIA +A D+ G S R + +PDG + Sbjct: 239 LHVLQGHCNSPIAGHAQVDRSGELSLRACVFTPDGKV 275
>HEM31_STRAW (Q82E76) Porphobilinogen deaminase 1 (EC 2.5.1.61) (PBG 1)| (Hydroxymethylbilane synthase 1) (HMBS 1) (Pre-uroporphyrinogen synthase 1) Length = 324 Score = 71.2 bits (173), Expect = 2e-12 Identities = 42/135 (31%), Positives = 69/135 (51%), Gaps = 6/135 (4%) Frame = -2 Query: 617 RLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREFL 438 R+ + T L VD +LPA QGA+ I C +++ ++ L+ L+ TR AV ER L Sbjct: 183 RIGRIDEVTEFLPVDTVLPAPGQGALAIECAADNADLIAALAELDDPFTRAAVTAERSLL 242 Query: 437 SVLDGNCRTPIAAYAYRDKDG----NCSFRGLLASPDGSIVYETSRSGTY--SFDDMVAI 276 + L+ C P+ A A DG RG++ + DGS + + S +G + D +A+ Sbjct: 243 AALEAGCSAPVGALADLLADGQIVTEMRLRGVVGTTDGSTLVQLSTTGPVPETHDQAMAL 302 Query: 275 GQDAGHELKSKAGPG 231 G++ E+ +K G Sbjct: 303 GRELAAEMLAKGAAG 317
>HEM3_MYCTU (P64336) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 309 Score = 71.2 bits (173), Expect = 2e-12 Identities = 43/113 (38%), Positives = 60/113 (53%), Gaps = 8/113 (7%) Frame = -2 Query: 617 RLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREFL 438 RL + T L +MLPA AQGA+ + CR+ D +++ L+ L+ DTR AV ER L Sbjct: 168 RLGRLDDVTETLEPVQMLPAPAQGALAVECRAGDSRLVAVLAELDDADTRAAVTAERALL 227 Query: 437 SVLDGNCRTPIAAYA----YRDKDG----NCSFRGLLASPDGSIVYETSRSGT 303 + L+ C P+ A A D+DG S RG +A+ DGS V S G+ Sbjct: 228 ADLEAGCSAPVGAIAEVVESIDEDGRVFEELSLRGCVAALDGSDVIRASGIGS 280
>HEM3_MYCBO (P64337) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 309 Score = 71.2 bits (173), Expect = 2e-12 Identities = 43/113 (38%), Positives = 60/113 (53%), Gaps = 8/113 (7%) Frame = -2 Query: 617 RLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREFL 438 RL + T L +MLPA AQGA+ + CR+ D +++ L+ L+ DTR AV ER L Sbjct: 168 RLGRLDDVTETLEPVQMLPAPAQGALAVECRAGDSRLVAVLAELDDADTRAAVTAERALL 227 Query: 437 SVLDGNCRTPIAAYA----YRDKDG----NCSFRGLLASPDGSIVYETSRSGT 303 + L+ C P+ A A D+DG S RG +A+ DGS V S G+ Sbjct: 228 ADLEAGCSAPVGAIAEVVESIDEDGRVFEELSLRGCVAALDGSDVIRASGIGS 280
>HEM3_BACHK (Q6HD62) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 309 Score = 70.9 bits (172), Expect = 3e-12 Identities = 42/117 (35%), Positives = 60/117 (51%) Frame = -2 Query: 602 ETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREFLSVLDG 423 E T L +PAV QGA+ I CR +D +++ L+ +N T VA ER FL L+G Sbjct: 180 EVITEHLDETLCVPAVGQGALAIECREDDKDLLQLLAHINDAVTERTVAAERVFLHKLEG 239 Query: 422 NCRTPIAAYAYRDKDGNCSFRGLLASPDGSIVYETSRSGTYSFDDMVAIGQDAGHEL 252 C+ PIA YA ++ L+ S DGSI+ + + GT D +G +A L Sbjct: 240 GCQVPIAGYATLTENDAIELTALVGSMDGSILLKETVVGT----DPEKVGLEAADRL 292
>HEM3_BACCZ (Q633Y0) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 309 Score = 70.5 bits (171), Expect = 4e-12 Identities = 41/117 (35%), Positives = 60/117 (51%) Frame = -2 Query: 602 ETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREFLSVLDG 423 E T L +PAV QGA+ I CR +D +++ L+ +N T VA ER FL L+G Sbjct: 180 EVITEHLDETLCVPAVGQGALAIECREDDTDLLQLLAHINDAVTERTVAAERVFLHKLEG 239 Query: 422 NCRTPIAAYAYRDKDGNCSFRGLLASPDGSIVYETSRSGTYSFDDMVAIGQDAGHEL 252 C+ PIA YA ++ L+ S DGS++ + + GT D +G +A L Sbjct: 240 GCQVPIAGYATLTENDAIELTALVGSMDGSVLLKETVVGT----DPEKVGLEAADRL 292
>HEM3_RALSO (Q8XWW3) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 334 Score = 70.1 bits (170), Expect = 5e-12 Identities = 37/95 (38%), Positives = 54/95 (56%) Frame = -2 Query: 620 KRLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREF 441 KRL ++E +V++ + LPA QGA+GI R + + +L+ L+H T LAV ER Sbjct: 191 KRLGLSERIRAVIAPETSLPAAGQGALGIESRVDRHDVQAWLAPLHHAPTALAVTAERAV 250 Query: 440 LSVLDGNCRTPIAAYAYRDKDGNCSFRGLLASPDG 336 L G+C+ P+AA+A G R +ASPDG Sbjct: 251 SRQLGGSCQVPLAAFAQWTDAGALRLRAFVASPDG 285
>HEM3_DEBHA (Q6BM23) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 361 Score = 70.1 bits (170), Expect = 5e-12 Identities = 42/129 (32%), Positives = 61/129 (47%), Gaps = 2/129 (1%) Frame = -2 Query: 617 RLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREFL 438 R+ + + T+ L EM AV QGA+GI R D+KM++ L ++ T ER + Sbjct: 199 RIGLGDRITAHLDAPEMYYAVGQGALGIEIRKGDEKMLQLLKTIEDLPTTYCCLAERSLM 258 Query: 437 SVLDGNCRTPIAAYA-YRDKDGNCSFRGLLASPDGSIVYETSRSGTY-SFDDMVAIGQDA 264 L+G C PI + Y + S + ++ SPDG E G + DD AIG Sbjct: 259 RHLEGGCSVPIGVQSHYNESTNELSLKAIIVSPDGIHFVEDEYKGVVNNKDDADAIGIKV 318 Query: 263 GHELKSKAG 237 G L +K G Sbjct: 319 GDLLSAKGG 327
>HEM3_BACC1 (Q72ZW2) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 309 Score = 70.1 bits (170), Expect = 5e-12 Identities = 41/117 (35%), Positives = 60/117 (51%) Frame = -2 Query: 602 ETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREFLSVLDG 423 E T L +PAV QGA+ I CR +D +++ L+ +N T VA ER FL L+G Sbjct: 180 EVITEHLDETLCVPAVGQGALAIECREDDKDLLQLLAHMNDGVTEKTVAAERVFLHKLEG 239 Query: 422 NCRTPIAAYAYRDKDGNCSFRGLLASPDGSIVYETSRSGTYSFDDMVAIGQDAGHEL 252 C+ PIA YA ++ L+ S DGS++ + + GT D +G +A L Sbjct: 240 GCQVPIAGYATLTENDAIELTALVGSMDGSVLLKETVVGT----DPEKVGLEAADRL 292
>HEM3_BACAN (Q81LC7) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 309 Score = 70.1 bits (170), Expect = 5e-12 Identities = 41/117 (35%), Positives = 60/117 (51%) Frame = -2 Query: 602 ETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREFLSVLDG 423 E T L +PAV QGA+ I CR +D +++ L+ +N T VA ER FL L+G Sbjct: 180 EVITEHLDETLCVPAVGQGALAIECREDDKDLLQLLAHINDAVTEKTVAAERVFLHKLEG 239 Query: 422 NCRTPIAAYAYRDKDGNCSFRGLLASPDGSIVYETSRSGTYSFDDMVAIGQDAGHEL 252 C+ PIA YA ++ L+ S DGS++ + + GT D +G +A L Sbjct: 240 GCQVPIAGYATITENDAIELTALVGSMDGSVLLKETVVGT----DPEKVGLEAADRL 292
>HEM3_MYCPA (Q73SS0) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 315 Score = 69.7 bits (169), Expect = 7e-12 Identities = 43/113 (38%), Positives = 58/113 (51%), Gaps = 8/113 (7%) Frame = -2 Query: 617 RLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREFL 438 RL T L +MLPA AQGA+ + CR+ D ++ L+ L+ DTR +V ER L Sbjct: 168 RLGRLGDVTETLEPVQMLPAPAQGALAVECRAGDSRLAAVLAELDDADTRASVTAERALL 227 Query: 437 SVLDGNCRTPIAAYA----YRDKDG----NCSFRGLLASPDGSIVYETSRSGT 303 + L+ C P+ A A D+DG S RG +A+ DGS V S GT Sbjct: 228 AELEAGCSAPVGAIAEVVESIDEDGRIFEELSLRGCVAALDGSDVIRASGIGT 280
>HEM3_CAMJE (Q9PHW9) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 307 Score = 69.3 bits (168), Expect = 9e-12 Identities = 45/128 (35%), Positives = 68/128 (53%), Gaps = 2/128 (1%) Frame = -2 Query: 620 KRLHMAETATSV--LSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACER 447 KRL++ + V S DE++PA +QGA+GI ND+K++E L LN E+ + + ER Sbjct: 171 KRLNLDKQVNFVYEFSKDELIPAASQGALGIES-INDEKILELLKCLNDENALIETSIER 229 Query: 446 EFLSVLDGNCRTPIAAYAYRDKDGNCSFRGLLASPDGSIVYETSRSGTYSFDDMVAIGQD 267 EF++ L+G C+ PI A D C R +L PDGS + + R +D G+ Sbjct: 230 EFIATLEGGCQVPIGINAELLGDEIC-VRAVLGLPDGSEILKDKR--MIKKNDFKGFGES 286 Query: 266 AGHELKSK 243 E +K Sbjct: 287 LAKEFIAK 294
>HEM3_BACCR (Q817R0) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 309 Score = 68.6 bits (166), Expect = 1e-11 Identities = 34/88 (38%), Positives = 51/88 (57%) Frame = -2 Query: 566 LPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREFLSVLDGNCRTPIAAYAYR 387 +PAV QGA+ I CR +D +++ L+ +N T VA ER FL L+G C+ PIA YA Sbjct: 192 VPAVGQGALAIECREDDKDLLQLLAHINDTITERTVAAERVFLHKLEGGCQVPIAGYATL 251 Query: 386 DKDGNCSFRGLLASPDGSIVYETSRSGT 303 ++ L+ S DGS++ + + GT Sbjct: 252 TENDAIELTALVGSMDGSVLLKETVVGT 279
>HEM32_STRAW (Q82P95) Porphobilinogen deaminase 2 (EC 2.5.1.61) (PBG 2)| (Hydroxymethylbilane synthase 2) (HMBS 2) (Pre-uroporphyrinogen synthase 2) Length = 314 Score = 68.6 bits (166), Expect = 1e-11 Identities = 33/98 (33%), Positives = 51/98 (52%) Frame = -2 Query: 620 KRLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREF 441 +R+ + T VL + M+P + G + + CR D ++E +S L T ER F Sbjct: 180 ERIGREDVITEVLEPETMMPPIGAGILALQCREGDTGLIETISELGDPGTHREATAERMF 239 Query: 440 LSVLDGNCRTPIAAYAYRDKDGNCSFRGLLASPDGSIV 327 L VL G+C +PIA YA +++G S R + + DG V Sbjct: 240 LHVLQGHCNSPIAGYARTERNGELSLRASVFTLDGKTV 277
>HEM3_MYCLE (Q49808) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 315 Score = 68.2 bits (165), Expect = 2e-11 Identities = 42/113 (37%), Positives = 58/113 (51%), Gaps = 8/113 (7%) Frame = -2 Query: 617 RLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREFL 438 RL + T L +M+PA AQGAI + CR+ D +++ L++L+ DTR AV ER L Sbjct: 168 RLGRLDEVTETLDPVQMVPAPAQGAIAVECRAGDSRLVAVLAALDDADTRAAVTAERVLL 227 Query: 437 SVLDGNCRTPIAAYA--YRDKDG------NCSFRGLLASPDGSIVYETSRSGT 303 + L+ C P+ A A DG S RG +A+ DGS V S T Sbjct: 228 AELEAGCSAPVGAIAQVVESIDGEGRVFEELSLRGCVAALDGSDVIRASGIST 280
>HEM3_OCEIH (Q8CXC0) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 309 Score = 68.2 bits (165), Expect = 2e-11 Identities = 39/127 (30%), Positives = 63/127 (49%) Frame = -2 Query: 602 ETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREFLSVLDG 423 E T L + +PAV QGA+ I R +D+++ + ++ T V+ ER FL +L+G Sbjct: 180 ELITEYLEPEVCVPAVGQGALAIESREDDEELTNIVKKIHDAYTAKTVSAERTFLHLLEG 239 Query: 422 NCRTPIAAYAYRDKDGNCSFRGLLASPDGSIVYETSRSGTYSFDDMVAIGQDAGHELKSK 243 C+ PI YAY D D L+ PDG+ + + + GT + +G++A L S+ Sbjct: 240 GCQVPIGGYAYLDGD-EVVLTALVGDPDGTTILKETVRGT----EPTEVGKEAAELLISQ 294 Query: 242 AGPGFFD 222 D Sbjct: 295 GAKEIVD 301
>HEM3_BORPE (Q7VVU9) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 314 Score = 67.8 bits (164), Expect = 2e-11 Identities = 43/123 (34%), Positives = 61/123 (49%) Frame = -2 Query: 620 KRLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREF 441 +RL +A ++L D+ LPA QGA+GI + L+ L T V ER Sbjct: 176 ERLGLAARIRALLEPDDSLPAAGQGALGIEILQGRADVRAMLAPLGDAATLACVTAERAV 235 Query: 440 LSVLDGNCRTPIAAYAYRDKDGNCSFRGLLASPDGSIVYETSRSGTYSFDDMVAIGQDAG 261 +L G+C+ P+AAYA D D + R L+A+PDG + R G D AIG+ A Sbjct: 236 SRMLGGSCQVPLAAYARIDGD-ELALRALVAAPDGRRIVRAERRGPR--DQAQAIGESAA 292 Query: 260 HEL 252 +L Sbjct: 293 RDL 295
>HEM3_ACIAD (Q6FFA9) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 311 Score = 67.8 bits (164), Expect = 2e-11 Identities = 35/105 (33%), Positives = 58/105 (55%) Frame = -2 Query: 620 KRLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREF 441 KRL + ++ + LPAV QGA+G+ CR+ND K+++ ++ L H+ T V ER F Sbjct: 178 KRLGLISRIRHSINAEISLPAVGQGALGLECRANDKKILDLIAPLAHQPTSACVRAERAF 237 Query: 440 LSVLDGNCRTPIAAYAYRDKDGNCSFRGLLASPDGSIVYETSRSG 306 + L+G C+ PIA +A ++ + G + S DG + + G Sbjct: 238 NAYLEGGCQVPIAGFATLTQE-CLTLEGRVGSVDGKTLLKDHVEG 281
>HEM31_STRCO (Q9WX16) Porphobilinogen deaminase 1 (EC 2.5.1.61) (PBG 1)| (Hydroxymethylbilane synthase 1) (HMBS 1) (Pre-uroporphyrinogen synthase 1) Length = 319 Score = 67.8 bits (164), Expect = 2e-11 Identities = 40/135 (29%), Positives = 69/135 (51%), Gaps = 6/135 (4%) Frame = -2 Query: 617 RLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREFL 438 R+ + T LSVD +LPA QGA+ + C +++ ++ L+ L+ TR AV ER L Sbjct: 178 RVGRIDEVTDFLSVDTVLPAPGQGALAVECAADNASLIAALAELDDPFTRAAVTAERSLL 237 Query: 437 SVLDGNCRTPIAAYAYRDKDG----NCSFRGLLASPDGSIVYETSRSGTY--SFDDMVAI 276 + L+ C P+ A A DG RG++ + DGS + + S +G + + +A+ Sbjct: 238 AALEAGCSAPVGALADLLADGQTVKEMRLRGVVGTTDGSTLVQLSTTGPVPETHEAALAL 297 Query: 275 GQDAGHELKSKAGPG 231 G + E+ ++ G Sbjct: 298 GGELAAEMLAQGAAG 312
>HEM3_SYNY3 (P73660) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 320 Score = 67.4 bits (163), Expect = 3e-11 Identities = 41/126 (32%), Positives = 65/126 (51%) Frame = -2 Query: 620 KRLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREF 441 +RL MA ++ + L AV QGA+GI CR D +++ L L E++R ER F Sbjct: 182 ERLDMANRIDQLIPPEISLHAVGQGALGIECREGDQEILSLLKVLEDENSRDRCLAERAF 241 Query: 440 LSVLDGNCRTPIAAYAYRDKDGNCSFRGLLASPDGSIVYETSRSGTYSFDDMVAIGQDAG 261 L L+G C+ PI + D D N + G++AS DG + + + S + +GQD Sbjct: 242 LRQLEGGCQVPIGVNTHLDGD-NLTLTGMVASLDGQRLIKDTLSAPRK--EAEKLGQDLA 298 Query: 260 HELKSK 243 +L+ + Sbjct: 299 LKLREQ 304
>HEM3_SYNEL (Q8DIE4) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 320 Score = 66.6 bits (161), Expect = 6e-11 Identities = 41/126 (32%), Positives = 63/126 (50%) Frame = -2 Query: 620 KRLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREF 441 +RL + + VL L AV QGA+GI CR+ D ++ + +L H +T ER F Sbjct: 181 RRLGFGDRISQVLPATVSLYAVGQGALGIECRAEDADILALVKTLEHPETTARCLAERAF 240 Query: 440 LSVLDGNCRTPIAAYAYRDKDGNCSFRGLLASPDGSIVYETSRSGTYSFDDMVAIGQDAG 261 L L+G C+ PI + + +G + GL+AS DG + + S +G VA ++ G Sbjct: 241 LRQLEGGCQVPIGVHTVIE-NGQLTLTGLVASLDGQRLVKDSLTGD------VATAEELG 293 Query: 260 HELKSK 243 L K Sbjct: 294 TRLALK 299
>HEM3_NOCFA (Q5YP70) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 346 Score = 66.6 bits (161), Expect = 6e-11 Identities = 43/112 (38%), Positives = 55/112 (49%), Gaps = 8/112 (7%) Frame = -2 Query: 617 RLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREFL 438 R+ T L +MLPA AQGA+ + CRS D ++E L+ L+ TR AV ER L Sbjct: 176 RIGRTAVITEALEPVQMLPAPAQGALAVECRSEDAALIEALAELDDAATRAAVVAERALL 235 Query: 437 SVLDGNCRTPIAAYA----YRDKDG----NCSFRGLLASPDGSIVYETSRSG 306 + L+ C P+ A A D DG S RG A+ DGS V S G Sbjct: 236 AELEAGCTAPVGALAEVVESLDDDGRIVEELSLRGCAAAVDGSEVLRASVVG 287
>HEM3_RHOBA (Q7UPN0) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 337 Score = 66.2 bits (160), Expect = 7e-11 Identities = 37/97 (38%), Positives = 53/97 (54%), Gaps = 3/97 (3%) Frame = -2 Query: 617 RLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREFL 438 RL M + + +DEM+PA QGA+GI RS+D M+ +++LN RLA ER+ L Sbjct: 190 RLEMTDLPHRLFPLDEMIPAPGQGALGIEVRSDDAGAMDAIANLNDAAARLAATAERKVL 249 Query: 437 SVLDGNCRTPIAAYAYRDKDGN---CSFRGLLASPDG 336 S L G C PIA +A + + R ++ S DG Sbjct: 250 SELHGGCLAPIACHAKLETSNHGTELCLRAIVMSADG 286
>HEM3_ANASP (Q8YVU6) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 323 Score = 65.9 bits (159), Expect = 9e-11 Identities = 42/117 (35%), Positives = 64/117 (54%), Gaps = 1/117 (0%) Frame = -2 Query: 620 KRLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREF 441 +RL M + +L + L AV QGA+GI CR++D +++ L ++ H +TR ER F Sbjct: 184 QRLGMGDRVHQILPKEISLHAVGQGALGIECRADDAELITVLKAIEHPETRDRCLAERSF 243 Query: 440 LSVLDGNCRTPIAAYAYRDKDGN-CSFRGLLASPDGSIVYETSRSGTYSFDDMVAIG 273 L L+G C+ PI + +GN G++AS DG + + + SG S D AIG Sbjct: 244 LRSLEGGCQVPIGVNT--EINGNELILTGVVASVDGQNLVKDTVSGNAS--DAEAIG 296
>HEM3_CANAL (O94048) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 340 Score = 65.1 bits (157), Expect = 2e-10 Identities = 39/134 (29%), Positives = 62/134 (46%), Gaps = 2/134 (1%) Frame = -2 Query: 617 RLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREFL 438 RL + TS L D+M AV QGA+GI R DD + L + + ER + Sbjct: 194 RLGLGHRITSYL--DDMYYAVGQGALGIEIRKGDDNIKSILKKIEDPIATICCLAERSLM 251 Query: 437 SVLDGNCRTPIAAYA-YRDKDGNCSFRGLLASPDGSIVYETSRSGTYSFD-DMVAIGQDA 264 L+G C P+ ++ Y + + +G++ SPDG++ E + D D +G + Sbjct: 252 RYLEGGCSVPLGVHSDYNESKQELTLKGIIVSPDGTVSIEDEVIKRITCDEDCEQVGIEL 311 Query: 263 GHELKSKAGPGFFD 222 G +LK+K D Sbjct: 312 GDKLKAKGAKEILD 325
>HEM3_BORPA (Q7W785) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 314 Score = 64.7 bits (156), Expect = 2e-10 Identities = 42/123 (34%), Positives = 60/123 (48%) Frame = -2 Query: 620 KRLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREF 441 +RL +A ++L + LPA QGA+GI + L+ L T V ER Sbjct: 176 ERLGLAARIRALLEPADSLPAAGQGALGIEILQGRADVRAMLAPLGDAATLACVTAERAV 235 Query: 440 LSVLDGNCRTPIAAYAYRDKDGNCSFRGLLASPDGSIVYETSRSGTYSFDDMVAIGQDAG 261 +L G+C+ P+AAYA D D + R L+A+PDG + R G D AIG+ A Sbjct: 236 SRMLGGSCQVPLAAYARIDGD-ELALRALVAAPDGRRIVRAERRGPR--DQAQAIGESAA 292 Query: 260 HEL 252 +L Sbjct: 293 RDL 295
>HEM3_BORBR (Q7WKM1) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 314 Score = 64.7 bits (156), Expect = 2e-10 Identities = 42/123 (34%), Positives = 60/123 (48%) Frame = -2 Query: 620 KRLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREF 441 +RL +A ++L + LPA QGA+GI + L+ L T V ER Sbjct: 176 ERLGLAARIRALLEPADSLPAAGQGALGIEILQGRADVRAMLAPLGDAATLACVTAERAV 235 Query: 440 LSVLDGNCRTPIAAYAYRDKDGNCSFRGLLASPDGSIVYETSRSGTYSFDDMVAIGQDAG 261 +L G+C+ P+AAYA D D + R L+A+PDG + R G D AIG+ A Sbjct: 236 SRMLGGSCQVPLAAYARIDGD-ELALRALVAAPDGRRIVRAERRGPR--DQAQAIGESAA 292 Query: 260 HEL 252 +L Sbjct: 293 RDL 295
>HEM3_HELHP (Q7VFE9) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 321 Score = 63.9 bits (154), Expect = 4e-10 Identities = 34/103 (33%), Positives = 59/103 (57%) Frame = -2 Query: 587 VLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREFLSVLDGNCRTP 408 ++ +D M+PA+ QGA+GI R D + ++ LN + + L V+ ER F+ L+G C+ P Sbjct: 191 IVPLDFMIPAMGQGALGIEMR-KDSIFFDRIAVLNDKQSALCVSAERAFVRTLEGGCQVP 249 Query: 407 IAAYAYRDKDGNCSFRGLLASPDGSIVYETSRSGTYSFDDMVA 279 I YA + + + + ++ PDGS V + S + + DD+ A Sbjct: 250 IGVYA-QFSNNKLTLQAIVGLPDGSEVLQDSVEDSINIDDINA 291
>HEM3_CORGL (Q8NT90) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 302 Score = 63.9 bits (154), Expect = 4e-10 Identities = 31/78 (39%), Positives = 47/78 (60%) Frame = -2 Query: 617 RLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREFL 438 R+ M + AT V D ++PA AQGA+ I CR++D + + L+ L H DT ++ ER L Sbjct: 168 RVGMQDRATEVFDADIIMPAPAQGALAIECRADDTETVRALNMLMHADTFVSAVAERTVL 227 Query: 437 SVLDGNCRTPIAAYAYRD 384 + L+ C P+AA+A D Sbjct: 228 NRLEAGCTAPVAAHATLD 245
>HEM3_THET2 (Q72H57) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 301 Score = 63.9 bits (154), Expect = 4e-10 Identities = 38/127 (29%), Positives = 56/127 (44%) Frame = -2 Query: 617 RLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREFL 438 RL + L E+LPA QGA+ + R DD E +L+H + V ER FL Sbjct: 169 RLDLRNRIDEFLDPGEVLPAPGQGALALEVREGDDLAEELCYALHHPPSYHRVRAERAFL 228 Query: 437 SVLDGNCRTPIAAYAYRDKDGNCSFRGLLASPDGSIVYETSRSGTYSFDDMVAIGQDAGH 258 L C P+ A A+ ++DG G+L +PDG G S + +G D Sbjct: 229 RGLGAGCLAPVGALAHVEEDGTLRLEGVLLTPDGKSFIRAEIEGDVS--EAEELGLDLAR 286 Query: 257 ELKSKAG 237 ++ + G Sbjct: 287 DVLEQGG 293
>HEM3_CLOAB (Q97MU4) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 291 Score = 63.5 bits (153), Expect = 5e-10 Identities = 30/76 (39%), Positives = 49/76 (64%) Frame = -2 Query: 620 KRLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREF 441 KRL+M T SV+EM+PAV QGA+G+ + ++K + L+++++R+ V ER F Sbjct: 171 KRLNMENIITDYFSVEEMIPAVGQGALGVEIK-KENKNRDLFRKLDNKNSRMCVEAERSF 229 Query: 440 LSVLDGNCRTPIAAYA 393 + L+G+C + I AYA Sbjct: 230 MRTLNGDCHSTIGAYA 245
>HEM3_FUSNN (Q8RFP5) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 298 Score = 63.2 bits (152), Expect = 6e-10 Identities = 31/81 (38%), Positives = 46/81 (56%) Frame = -2 Query: 620 KRLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREF 441 KR +A+ T L+ + PA AQG + I CR ND+++ E L S+++E V EREF Sbjct: 175 KRTGLADKITEYLNGEVFPPAPAQGVLYIQCRENDEEIKEILKSIHNEAIAKIVEIEREF 234 Query: 440 LSVLDGNCRTPIAAYAYRDKD 378 + DG C TP+ Y+ + D Sbjct: 235 SKIFDGGCHTPMGCYSQVNGD 255
>HEM3_RICCN (Q92HR5) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 351 Score = 62.8 bits (151), Expect = 8e-10 Identities = 28/65 (43%), Positives = 40/65 (61%) Frame = -2 Query: 587 VLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREFLSVLDGNCRTP 408 ++ +MLP + QG I + R +D+ M+E + +NH T + ER FL LD NCRTP Sbjct: 186 LIEYSQMLPCIGQGVIAVEIRKDDNAMLEICNQINHLPTFELIKPERAFLEYLDANCRTP 245 Query: 407 IAAYA 393 IAAY+ Sbjct: 246 IAAYS 250
>HEM3_COREF (Q8FSF7) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 299 Score = 62.8 bits (151), Expect = 8e-10 Identities = 31/78 (39%), Positives = 45/78 (57%) Frame = -2 Query: 617 RLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREFL 438 R+ M + AT V D ++PA AQGA+ I CR D+ ++ L+ L H DT + ER L Sbjct: 168 RVGMQDRATQVFDPDMLMPAPAQGALAIECRVEDEDIITGLNMLMHADTYVTAVAERTVL 227 Query: 437 SVLDGNCRTPIAAYAYRD 384 + L+ C P+AA+A D Sbjct: 228 NRLEAGCTAPVAAHATLD 245
>HEM3_BURPS (Q63W73) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 329 Score = 62.0 bits (149), Expect = 1e-09 Identities = 42/138 (30%), Positives = 70/138 (50%), Gaps = 3/138 (2%) Frame = -2 Query: 620 KRLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREF 441 KRL +A ++L VD+ LPA QGA+GI + + +L+ L+ + LAV ER Sbjct: 183 KRLGLAARIRALLDVDDSLPAAGQGALGIEIAARRADVAAWLAPLHDHASALAVEAERAV 242 Query: 440 LSVLDGNCRTPIAAYAYRDKDGNCSFRGLLASPDGSIV---YETSRSGTYSFDDMVAIGQ 270 L G+C P+AA+A + G G +++ DG+ V + +R+ T + D +A+G+ Sbjct: 243 SRALGGSCEVPLAAHAVW-RGGELHLTGSVSTTDGARVLAAHAHARAATAA--DALALGR 299 Query: 269 DAGHELKSKAGPGFFDGL 216 L+ + D L Sbjct: 300 RVSDALERQGARAIVDAL 317
>HEM3_BURMA (Q62LC0) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 329 Score = 62.0 bits (149), Expect = 1e-09 Identities = 42/138 (30%), Positives = 70/138 (50%), Gaps = 3/138 (2%) Frame = -2 Query: 620 KRLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREF 441 KRL +A ++L VD+ LPA QGA+GI + + +L+ L+ + LAV ER Sbjct: 183 KRLGLAARIRALLDVDDSLPAAGQGALGIEIAARRADVAAWLAPLHDHASALAVEAERAV 242 Query: 440 LSVLDGNCRTPIAAYAYRDKDGNCSFRGLLASPDGSIV---YETSRSGTYSFDDMVAIGQ 270 L G+C P+AA+A + G G +++ DG+ V + +R+ T + D +A+G+ Sbjct: 243 SRALGGSCEVPLAAHAVW-RGGELHLTGSVSTTDGARVLAAHAHARAATAA--DALALGR 299 Query: 269 DAGHELKSKAGPGFFDGL 216 L+ + D L Sbjct: 300 RVSDALERQGARAIVDAL 317
>HEM3_XANAC (Q8PPR3) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 304 Score = 61.6 bits (148), Expect = 2e-09 Identities = 40/127 (31%), Positives = 66/127 (51%), Gaps = 1/127 (0%) Frame = -2 Query: 620 KRLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREF 441 +RL + ++ L E LPA AQGA+ + CR +D ++ L+ L+ TR+ V ER Sbjct: 173 QRLGLEARISARLDAPEWLPAPAQGAVAVECRGDDARIHSLLAVLDAGRTRVCVEAERAM 232 Query: 440 LSVLDGNCRTPIAAYAYRDKDGNCSFRGLLAS-PDGSIVYETSRSGTYSFDDMVAIGQDA 264 L G+C P+AA+A R + + +G++ S DG +++ + S DD A+G+ Sbjct: 233 NRALHGSCHVPVAAFA-RWEGQDLFLQGMVGSASDGRLIHADAHG---SADDTEALGRRV 288 Query: 263 GHELKSK 243 L K Sbjct: 289 AQGLFDK 295
>HEM3_AQUAE (O66621) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 304 Score = 61.6 bits (148), Expect = 2e-09 Identities = 37/128 (28%), Positives = 64/128 (50%) Frame = -2 Query: 620 KRLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREF 441 KR+ T VL ++ +PAV QG++ I R D ++ E + LN+E++ L ER F Sbjct: 171 KRMGYESEITEVL--EDFIPAVGQGSLAIEIREGDKRIEELIKPLNNEESFLCAIAERTF 228 Query: 440 LSVLDGNCRTPIAAYAYRDKDGNCSFRGLLASPDGSIVYETSRSGTYSFDDMVAIGQDAG 261 L L+G C+ P+ A+A + ++G + ++ + E R G + ++ +G Sbjct: 229 LRRLEGGCQVPVGAFA-KIENGTLKMKAFISDIEAERYIEGYREG--NPEEAEKLGLSLA 285 Query: 260 HELKSKAG 237 EL K G Sbjct: 286 EELLKKGG 293
>HEM3_LEGPH (Q5ZRY6) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 309 Score = 61.6 bits (148), Expect = 2e-09 Identities = 35/114 (30%), Positives = 59/114 (51%) Frame = -2 Query: 620 KRLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREF 441 +R+ +A T ++ D MLP AQGA+ I CR++D ++ E + LN + L V ER Sbjct: 175 ERMGLAHHITQLIPDDIMLPTCAQGALCIECRTDDLEIQELVHGLNDPISALCVHTERRV 234 Query: 440 LSVLDGNCRTPIAAYAYRDKDGNCSFRGLLASPDGSIVYETSRSGTYSFDDMVA 279 + L GNC P A Y ++ R + + DGS + + + G + +++A Sbjct: 235 NAKLGGNCHIPFAVYCTITEEKLLLLRAKVLNMDGSQMIDDEQQGKIAEAEVIA 288
>HEM3_LEGPL (Q5WT65) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 309 Score = 60.8 bits (146), Expect = 3e-09 Identities = 35/114 (30%), Positives = 57/114 (50%) Frame = -2 Query: 620 KRLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREF 441 +R+ +A T ++ D MLP AQGA+ I CR++D ++ E + LN + L V ER Sbjct: 175 ERMGLAHHITQLIPDDIMLPTCAQGALCIECRTDDLEIQELIYGLNDPISALCVHTERRV 234 Query: 440 LSVLDGNCRTPIAAYAYRDKDGNCSFRGLLASPDGSIVYETSRSGTYSFDDMVA 279 + L GNC P A Y + R + + DGS + + + G +++A Sbjct: 235 NAKLGGNCHIPFAVYCTITAENLLLLRAKVLNLDGSQMIDDEQQGKIEEAEIIA 288
>HEM3_CHLVI (P28464) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 311 Score = 60.5 bits (145), Expect = 4e-09 Identities = 33/94 (35%), Positives = 49/94 (52%) Frame = -2 Query: 617 RLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREFL 438 RL ++ T +L + MLPAV QGA+GI R++D + E + LN ++T + ER L Sbjct: 174 RLEFSDRITEILPHETMLPAVGQGALGIETRTDDAETREIVRVLNDDNTEMCCRAERALL 233 Query: 437 SVLDGNCRTPIAAYAYRDKDGNCSFRGLLASPDG 336 L G C+ PI ++ DG + S DG Sbjct: 234 RHLQGGCQIPIGSFG-SYIDGTLKLLAFVGSVDG 266
>HEM3_XANCP (Q8P536) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 304 Score = 60.5 bits (145), Expect = 4e-09 Identities = 35/113 (30%), Positives = 61/113 (53%), Gaps = 1/113 (0%) Frame = -2 Query: 620 KRLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREF 441 +RL + T+ L E LPA AQGA+ + CR +D ++ + L+ L+ TR V ER Sbjct: 173 QRLGLEARITARLDAPEWLPAPAQGAVAVECRGDDARIHDLLAVLDAGRTRACVEAERAM 232 Query: 440 LSVLDGNCRTPIAAYAYRDKDGNCSFRGLLAS-PDGSIVYETSRSGTYSFDDM 285 L G+C P+AA+A R + + +G++ S DG +++ + + +D+ Sbjct: 233 NRALHGSCHVPVAAFA-RWEGEDLFLQGMVGSASDGRLIHAEAHGSPDATEDL 284
>HEM3_LEGPA (Q5X1F2) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 309 Score = 60.5 bits (145), Expect = 4e-09 Identities = 35/114 (30%), Positives = 57/114 (50%) Frame = -2 Query: 620 KRLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREF 441 +R+ +A T ++ D MLP AQGA+ I CR++D ++ E + LN + L V ER Sbjct: 175 ERMGLAHHITQLIPDDIMLPTCAQGALCIECRTDDLEIQELIHGLNDPISALCVHTERRV 234 Query: 440 LSVLDGNCRTPIAAYAYRDKDGNCSFRGLLASPDGSIVYETSRSGTYSFDDMVA 279 + L GNC P A Y + R + + DGS + + + G +++A Sbjct: 235 NAKLGGNCHIPFAVYCTITAEKLLLLRAKVLNLDGSQMIDDEQQGKIEEAEIIA 288
>HEM3_RICPR (Q9ZD77) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 299 Score = 59.7 bits (143), Expect = 7e-09 Identities = 28/65 (43%), Positives = 37/65 (56%) Frame = -2 Query: 587 VLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREFLSVLDGNCRTP 408 ++ +MLP + QG I + R +D+ M S +NH T + ER FL LD NC TP Sbjct: 186 LIEYSKMLPCIGQGVIAVEIRKDDNAMFNICSQINHLPTFELIKPERAFLEYLDANCSTP 245 Query: 407 IAAYA 393 IAAYA Sbjct: 246 IAAYA 250
>HEM3_PASMU (Q9CK24) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 309 Score = 59.3 bits (142), Expect = 9e-09 Identities = 36/97 (37%), Positives = 51/97 (52%) Frame = -2 Query: 617 RLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREFL 438 RL + TS++ V + LPAV QGA+GI CR + ++ L+ L +T V ER Sbjct: 177 RLGQQQRITSLIDVTQCLPAVGQGAVGIECR-QEAEIELLLAPLADPETTACVLAERAMN 235 Query: 437 SVLDGNCRTPIAAYAYRDKDGNCSFRGLLASPDGSIV 327 L G C+ PIA YA + +G R L+ DGS + Sbjct: 236 RHLQGGCQVPIAGYAIIE-EGQLFLRALVGEVDGSSI 271
>HEM3_CHLTE (Q8KCJ4) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 312 Score = 58.5 bits (140), Expect = 2e-08 Identities = 28/74 (37%), Positives = 42/74 (56%) Frame = -2 Query: 617 RLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREFL 438 RL ++ + +L D MLPAV QGA+GI R++D + +E + +N +T + ER L Sbjct: 175 RLEFSDRISEILPHDVMLPAVGQGALGIETRTDDAETIEIVRVMNDSNTEICCRAERALL 234 Query: 437 SVLDGNCRTPIAAY 396 L G C+ PI Y Sbjct: 235 RHLQGGCQIPIGCY 248
>HEM3_METJA (Q57989) Probable porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 292 Score = 58.5 bits (140), Expect = 2e-08 Identities = 27/64 (42%), Positives = 37/64 (57%) Frame = -2 Query: 572 EMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREFLSVLDGNCRTPIAAYA 393 ++LPA AQG I +AC+ +D++M L +NHE T L CER L+ G C P A A Sbjct: 182 DILPAPAQGIIAVACKRDDEEMKSILKEINHERTYLESLCERTALNEFGGGCSVPFGALA 241 Query: 392 YRDK 381 D+ Sbjct: 242 VYDE 245
>HEM3_CORDI (Q6NJK0) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 294 Score = 58.2 bits (139), Expect = 2e-08 Identities = 32/97 (32%), Positives = 51/97 (52%) Frame = -2 Query: 617 RLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREFL 438 R+ + AT V + LPA AQGA+ + CR++D E + S+ E ++ ER L Sbjct: 166 RVGRGDEATQVFDPQDFLPAPAQGALAVECRADDAYAREAIDSICDEQAQVCAVTERVVL 225 Query: 437 SVLDGNCRTPIAAYAYRDKDGNCSFRGLLASPDGSIV 327 + L+ C P+AA+A + DG + + + DGS V Sbjct: 226 NRLEAGCTAPVAAHATLN-DGTLTLTAAVIALDGSKV 261
>HEM3_FRATT (Q5NI31) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 300 Score = 57.8 bits (138), Expect = 3e-08 Identities = 36/122 (29%), Positives = 55/122 (45%) Frame = -2 Query: 617 RLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREFL 438 RL + E T + V+ LPAV QG + I D+ ++E + LN ++ ER F Sbjct: 173 RLELVERITQFIPVEISLPAVGQGIVVIEALERDNDLLEKIQKLNCRESSRVATAERAFN 232 Query: 437 SVLDGNCRTPIAAYAYRDKDGNCSFRGLLASPDGSIVYETSRSGTYSFDDMVAIGQDAGH 258 L G C I AYA D + + ++AS DG + + G DD +G+ Sbjct: 233 QELKGGCHVAIGAYAELD-NNQITLMAMVASSDGKKILKRKMIG----DDPTKLGKLLAQ 287 Query: 257 EL 252 E+ Sbjct: 288 EM 289
>HEM3_ASHGO (Q75DY0) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 326 Score = 57.4 bits (137), Expect = 3e-08 Identities = 36/119 (30%), Positives = 58/119 (48%), Gaps = 3/119 (2%) Frame = -2 Query: 617 RLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREFL 438 RL + T ML AV QGA+GI R+ D+++ L+ + ++ + ER + Sbjct: 185 RLGLESRITQRFDSTIMLHAVGQGALGIETRTGDERLQAILAKVADRNSTICCLAERSLM 244 Query: 437 SVLDGNCRTPIAAYAYRDKDGN-CSFRGLLASPDGSIVYETSRSGTYSFD--DMVAIGQ 270 L+G C PI Y+ D++ + + GL+ S DG+ E + S D D +A GQ Sbjct: 245 RTLEGGCSVPIGVYSTFDEETSMLTLDGLVVSVDGADAAEATVSYKIKSDKEDAIACGQ 303
>HEM3_PROMP (Q7V2I1) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 316 Score = 57.4 bits (137), Expect = 3e-08 Identities = 35/124 (28%), Positives = 61/124 (49%) Frame = -2 Query: 620 KRLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREF 441 KRL ++ + L AV QGA+GI C+S+D ++++ +S L + + ER F Sbjct: 178 KRLGFESRVHQIIPNEISLHAVGQGALGIECKSDDKEVLKIISVLEDKVSSQRCLAERSF 237 Query: 440 LSVLDGNCRTPIAAYAYRDKDGNCSFRGLLASPDGSIVYETSRSGTYSFDDMVAIGQDAG 261 L L+G C+ PI + D + G++AS DG + + G + + +G+ Sbjct: 238 LRELEGGCQVPIGVNSSIQND-EIALIGMVASIDGKRLIKNESIGNIKYPE--EVGKKLA 294 Query: 260 HELK 249 +LK Sbjct: 295 EKLK 298
>HEM3_SYNPX (Q7U5C2) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 317 Score = 57.0 bits (136), Expect = 4e-08 Identities = 38/124 (30%), Positives = 59/124 (47%) Frame = -2 Query: 620 KRLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREF 441 +RL ++ D L AV QGA+GI C + +++E + L H T ER F Sbjct: 178 ERLGFGNRIHQIIPGDISLHAVGQGALGIECVEDKPEVLEIIKVLEHTTTSRRCLAERAF 237 Query: 440 LSVLDGNCRTPIAAYAYRDKDGNCSFRGLLASPDGSIVYETSRSGTYSFDDMVAIGQDAG 261 L L+G C+ PI + + + + G++AS DG + SG S D +IG + Sbjct: 238 LRELEGGCQVPIGVNSQINNE-ELTLTGMVASLDGKRLIRDEASG--SAADPESIGIELA 294 Query: 260 HELK 249 +LK Sbjct: 295 GKLK 298
>HEM3_PROMM (Q7V697) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 317 Score = 56.6 bits (135), Expect = 6e-08 Identities = 37/125 (29%), Positives = 59/125 (47%) Frame = -2 Query: 617 RLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREFL 438 RL + ++ + L AV QGA+GI C +++E + +L H+ T ER L Sbjct: 179 RLGFGDRIHQLIPSEISLHAVGQGALGIECVEGHPEVLEAIKALEHKPTAQRCLAERALL 238 Query: 437 SVLDGNCRTPIAAYAYRDKDGNCSFRGLLASPDGSIVYETSRSGTYSFDDMVAIGQDAGH 258 L+G C+ PI + R + G++AS DG + + G D AIG++ Sbjct: 239 RELEGGCQVPIGVNS-RIEANELLLTGMVASLDGKRLIRDQQRG--PIDRCEAIGKELAE 295 Query: 257 ELKSK 243 LKS+ Sbjct: 296 TLKSQ 300
>HEM3_PROMA (Q7VD89) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 315 Score = 56.6 bits (135), Expect = 6e-08 Identities = 34/125 (27%), Positives = 64/125 (51%) Frame = -2 Query: 617 RLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREFL 438 RL ++ + L AV QGA+GI C + +++++ + L H+++ L ER FL Sbjct: 179 RLGFGNRIHQLIPSEISLHAVGQGALGIECVKDKEEILQIIKVLEHKESSLRCLAERAFL 238 Query: 437 SVLDGNCRTPIAAYAYRDKDGNCSFRGLLASPDGSIVYETSRSGTYSFDDMVAIGQDAGH 258 L+G C+ PI + + + G++AS DG + +++G+ + IG + + Sbjct: 239 KELEGGCQVPIGVNS-KIQGQELILTGMVASLDGKQLIRDTKTGSSMHPE--TIGIELAN 295 Query: 257 ELKSK 243 LKS+ Sbjct: 296 TLKSQ 300
>HEM3_EUGGR (P13446) Porphobilinogen deaminase, chloroplast precursor (EC| 2.5.1.61) (PBG) (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 480 Score = 56.2 bits (134), Expect = 7e-08 Identities = 30/86 (34%), Positives = 46/86 (53%) Frame = -2 Query: 593 TSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREFLSVLDGNCR 414 T+++ + M PA QGA+ I R+ND ++ L L+H + VACER L+G C+ Sbjct: 337 TNIIDPNVMCPAAGQGALSIELRTNDPEIAALLEPLHHIPDAVTVACERAMNRRLNGGCQ 396 Query: 413 TPIAAYAYRDKDGNCSFRGLLASPDG 336 PI+ +A + KDG + S G Sbjct: 397 VPISGFA-QLKDGQLRMEARVGSVTG 421
>HEM3_YARLI (Q6C097) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 338 Score = 55.8 bits (133), Expect = 1e-07 Identities = 33/136 (24%), Positives = 63/136 (46%), Gaps = 1/136 (0%) Frame = -2 Query: 620 KRLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREF 441 KRL + + T L +ML AV QGA+G+ R D+K + L ++ +++ L ER Sbjct: 198 KRLDLGDRITGYLQKPDMLHAVGQGALGLEIRQGDEKTKKILEAIYDKESTLCCLAERAV 257 Query: 440 LSVLDGNCRTPIAAYAYRDKDGNCSFRGLLASPDGSIVYETSRSGTYSFD-DMVAIGQDA 264 + L+G C PI + ++G + ++ S +G+ E ++ + + +G+D Sbjct: 258 MRTLEGGCSVPIGVET-KYENGKLTLDAIVVSVEGTEFVECTQVRAVEENWEAEQLGKDV 316 Query: 263 GHELKSKAGPGFFDGL 216 +L D + Sbjct: 317 AEQLVKDGAKKILDAI 332
>HEM3_CLOPE (Q8XKG4) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 291 Score = 55.1 bits (131), Expect = 2e-07 Identities = 29/82 (35%), Positives = 44/82 (53%), Gaps = 1/82 (1%) Frame = -2 Query: 620 KRLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREF 441 KRL M + + LPA+ QGA+GI C + +Y +L+ ++ R V ER F Sbjct: 171 KRLGMEDVISDYFDPKVFLPAIGQGALGIECLKGGE-FNDYFKALDSKEVRTTVEAERSF 229 Query: 440 LSVLDGNCRTPIAAYA-YRDKD 378 + VL+G C + I AY+ +D D Sbjct: 230 MKVLNGGCHSLIGAYSEVKDND 251
>HEM3_HELPJ (Q9ZMJ7) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 306 Score = 55.1 bits (131), Expect = 2e-07 Identities = 34/99 (34%), Positives = 51/99 (51%), Gaps = 2/99 (2%) Frame = -2 Query: 581 SVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREFLSVLDGNCRTPIA 402 SV EM+P++ QGA+G+ N + L LN+E++ EREF+ L+G C+ PI Sbjct: 186 SVKEMIPSMGQGALGVEMLKNHKHFIT-LQKLNNEESAFCCHLEREFIKGLNGGCQIPIG 244 Query: 401 AYAYRDKDGNCSFRGLLASPDGSIVYETSRSG--TYSFD 291 +A D R +L P+G V + G T +FD Sbjct: 245 VHANLMGD-EVKIRAVLGLPNGKEVIAKEKQGDKTKAFD 282
>HEM3_MOUSE (P22907) Porphobilinogen deaminase (EC 2.5.1.61)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) (PBG-D) Length = 361 Score = 54.7 bits (130), Expect = 2e-07 Identities = 36/122 (29%), Positives = 58/122 (47%) Frame = -2 Query: 620 KRLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREF 441 +R+ +L +E + AV QGA+ + R+ D +++ +S L+ +T L ER F Sbjct: 194 QRMGWQNRVGQILHPEECMYAVGQGALAVEVRAKDQDILDLVSVLHDPETLLRCIAERAF 253 Query: 440 LSVLDGNCRTPIAAYAYRDKDGNCSFRGLLASPDGSIVYETSRSGTYSFDDMVAIGQDAG 261 L L+G C P+A + KDG G + S DGS + + T V + Q+ G Sbjct: 254 LRHLEGGCSVPVAVHTV-IKDGQLYLTGGVWSLDGSDSMQETMQATI----QVPVQQEDG 308 Query: 260 HE 255 E Sbjct: 309 PE 310
>HEM3_HUMAN (P08397) Porphobilinogen deaminase (EC 2.5.1.61)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) (PBG-D) Length = 361 Score = 54.7 bits (130), Expect = 2e-07 Identities = 30/85 (35%), Positives = 46/85 (54%) Frame = -2 Query: 587 VLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREFLSVLDGNCRTP 408 +L +E + AV QGA+G+ R+ D +++ + L+ +T L ER FL L+G C P Sbjct: 205 ILHPEECMYAVGQGALGVEVRAKDQDILDLVGVLHDPETLLRCIAERAFLRHLEGGCSVP 264 Query: 407 IAAYAYRDKDGNCSFRGLLASPDGS 333 +A + KDG G + S DGS Sbjct: 265 VAVHTAM-KDGQLYLTGGVWSLDGS 288
>HEM3_KLULA (Q6CT60) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 327 Score = 54.3 bits (129), Expect = 3e-07 Identities = 34/129 (26%), Positives = 57/129 (44%), Gaps = 3/129 (2%) Frame = -2 Query: 593 TSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREFLSVLDGNCR 414 T + D M AV QGA+GI R +D+KM + L + T + ER L L+G C Sbjct: 193 TQRFNADTMCYAVGQGALGIEIRKDDEKMKKILKEICDPSTTICCLAERSLLRTLEGGCS 252 Query: 413 TPIAAYA-YRDKDGNCSFRGLLASPDGSIVYETSRSGTYS--FDDMVAIGQDAGHELKSK 243 PI + Y + + +G++ + +G+ E T S +D + G++ +L Sbjct: 253 VPIGVVSNYDESTKVLTLKGIVINVEGTEWVEIEHKVTISNEREDSINCGKELAAKLTQN 312 Query: 242 AGPGFFDGL 216 D + Sbjct: 313 GAKEILDSI 321
>HEM3_RICTY (Q68WR3) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 299 Score = 54.3 bits (129), Expect = 3e-07 Identities = 25/65 (38%), Positives = 36/65 (55%) Frame = -2 Query: 587 VLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREFLSVLDGNCRTP 408 ++ ++LP V QG I + R +D+ M + +NH T + ER FL LD NC TP Sbjct: 186 LIEYSQILPCVGQGVIAVEIRKDDNAMFNICNQINHIPTFELIKPERAFLEHLDANCSTP 245 Query: 407 IAAYA 393 I AY+ Sbjct: 246 IGAYS 250
>HEM3_RAT (P19356) Porphobilinogen deaminase (EC 2.5.1.61)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) (PBG-D) Length = 361 Score = 53.9 bits (128), Expect = 4e-07 Identities = 35/122 (28%), Positives = 57/122 (46%) Frame = -2 Query: 620 KRLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREF 441 +R+ +L +E + AV QGA+ + R+ D +++ + L+ +T L ER F Sbjct: 194 QRMGWQNRVGQILHPEECMYAVGQGALAVEVRAKDQDILDLVGVLHDPETLLRCIAERAF 253 Query: 440 LSVLDGNCRTPIAAYAYRDKDGNCSFRGLLASPDGSIVYETSRSGTYSFDDMVAIGQDAG 261 L L+G C P+A + KDG G + S DGS + + T V + Q+ G Sbjct: 254 LRHLEGGCSVPVAVHTVM-KDGQLYLTGGVWSLDGSDSMQETMQATI----QVPVQQEDG 308 Query: 260 HE 255 E Sbjct: 309 PE 310
>HEM3_HELPY (P56140) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 306 Score = 53.9 bits (128), Expect = 4e-07 Identities = 34/99 (34%), Positives = 50/99 (50%), Gaps = 2/99 (2%) Frame = -2 Query: 581 SVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREFLSVLDGNCRTPIA 402 SV+EM+P++ QGA+G+ N K L LN E + EREF+ L+G C+ PI Sbjct: 186 SVEEMIPSMGQGALGVEMLKNH-KHFATLQKLNDEKSAFCCRLEREFIKGLNGGCQIPIG 244 Query: 401 AYAYRDKDGNCSFRGLLASPDGSIVYETSRSG--TYSFD 291 +A D + +L P+G V + G T +FD Sbjct: 245 VHASLMGD-RVKIQAVLGLPNGKEVITKEKQGDKTKAFD 282
>HEM3_WOLSU (Q7M8L2) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 311 Score = 53.1 bits (126), Expect = 6e-07 Identities = 31/97 (31%), Positives = 49/97 (50%), Gaps = 2/97 (2%) Frame = -2 Query: 617 RLHMAETATSVLSVDE--MLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACERE 444 RL + + V+ +D M+PA+ Q A+GI C+ + L + R+ ERE Sbjct: 174 RLDLWKEVNYVIPIDTEMMIPAMGQAALGIECKEGSEAF-RLTQILEDKKARIETTAERE 232 Query: 443 FLSVLDGNCRTPIAAYAYRDKDGNCSFRGLLASPDGS 333 F+ VL+G C+ PI A AY + + + + PDGS Sbjct: 233 FVRVLEGGCQVPIGANAYLEGE-TLHLKVAVGLPDGS 268
>HEM3_DEIRA (Q9RRY0) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 309 Score = 52.4 bits (124), Expect = 1e-06 Identities = 35/108 (32%), Positives = 53/108 (49%) Frame = -2 Query: 575 DEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREFLSVLDGNCRTPIAAY 396 D +LPA QGA+ + R+ DD +E +++ T + EREFL+ L C P+ A+ Sbjct: 191 DILLPAPGQGALALETRTEDDLTIEVAYAIHDHATDDRITAEREFLAGLGAGCMAPVGAH 250 Query: 395 AYRDKDGNCSFRGLLASPDGSIVYETSRSGTYSFDDMVAIGQDAGHEL 252 A K+G + G + + DG+ V + G VA D G EL Sbjct: 251 AV-IKNGLLTLEGWVGALDGTQVIRATSQGD------VAECADIGAEL 291
>HEM3_CANGA (Q6FNR4) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 329 Score = 52.0 bits (123), Expect = 1e-06 Identities = 28/100 (28%), Positives = 49/100 (49%), Gaps = 1/100 (1%) Frame = -2 Query: 617 RLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREFL 438 R+ + + T L D M AV QGA+GI R D K+++ L + ++ + ER + Sbjct: 185 RMGLEDRITQRLHSDIMYHAVGQGALGIEIRQGDKKILQILDEIADLESTVCCLAERSLM 244 Query: 437 SVLDGNCRTPIAA-YAYRDKDGNCSFRGLLASPDGSIVYE 321 L+G C PI +Y K +G++ + +G++ E Sbjct: 245 RTLEGGCSVPIGVESSYDHKTKKLLLKGIVVNVEGTMAIE 284
>HEM3_PROAC (Q6AB05) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 334 Score = 51.6 bits (122), Expect = 2e-06 Identities = 30/78 (38%), Positives = 41/78 (52%), Gaps = 3/78 (3%) Frame = -2 Query: 617 RLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDD---KMMEYLSSLNHEDTRLAVACER 447 RL + T L +LPA AQGA+ + CR+ D K+ + L+ ++ TRLA ER Sbjct: 181 RLGHSGAVTEFLDPSVVLPAPAQGALAVECRTADSRHGKLAKALARIDDRRTRLAATAER 240 Query: 446 EFLSVLDGNCRTPIAAYA 393 LS L+ C PI A A Sbjct: 241 AVLSHLEAGCAAPIGALA 258
>HEM3_SCHPO (Q09899) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 336 Score = 51.6 bits (122), Expect = 2e-06 Identities = 31/98 (31%), Positives = 47/98 (47%), Gaps = 4/98 (4%) Frame = -2 Query: 617 RLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREFL 438 RL + + +L+ + AV QGA+ + R++D +M+E L L H++T A ER + Sbjct: 185 RLGLKDRIAQMLTAPFVYYAVGQGALAVEVRADDKEMIEMLKPLQHQETLYACLAERALM 244 Query: 437 SVLDGNCRTPIAAYAYRDKDGNCSFR----GLLASPDG 336 L G C PI N S+R G + S DG Sbjct: 245 KRLQGGCAIPIGVQTDVLAISNSSYRISLLGTVLSADG 282
>HEM3_CLOJO (Q59293) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 291 Score = 51.6 bits (122), Expect = 2e-06 Identities = 28/76 (36%), Positives = 42/76 (55%) Frame = -2 Query: 620 KRLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREF 441 KRL + SVDE+LPA +QG I + R ++ ++L + E++ ER F Sbjct: 168 KRLGLESRIGRYFSVDEILPAASQGIIAVQGRVGEN--FDFLKLFHSEESLCISLAERTF 225 Query: 440 LSVLDGNCRTPIAAYA 393 + ++G C TPIAAYA Sbjct: 226 VREMNGGCSTPIAAYA 241
>HEM3_XYLFA (Q9PCX7) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 305 Score = 51.6 bits (122), Expect = 2e-06 Identities = 33/99 (33%), Positives = 50/99 (50%), Gaps = 1/99 (1%) Frame = -2 Query: 620 KRLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREF 441 +RL + + T+ L+ E LPA QGAI + + D ++ L+ L+ TR V ER Sbjct: 173 RRLGLEQRMTARLAPPEWLPAPGQGAIAVESLTEDARIGTLLAGLDDLPTRQCVVAERTM 232 Query: 440 LSVLDGNCRTPIAAYAYRDKDGNCSFRGLLAS-PDGSIV 327 L G+C P+ AYA + G +GL+ DG +V Sbjct: 233 NRALHGSCHVPVGAYASYEV-GGMRLQGLVGCVADGRLV 270
>HEM3_XYLFT (Q87CC9) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 305 Score = 51.2 bits (121), Expect = 2e-06 Identities = 33/99 (33%), Positives = 50/99 (50%), Gaps = 1/99 (1%) Frame = -2 Query: 620 KRLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREF 441 +RL + + T+ L+ E LPA QGAI + + D ++ L+ L+ TR V ER Sbjct: 173 RRLGLEQRMTARLAPPEWLPAPGQGAIAVESLTEDARIGTLLAGLDDLPTRKCVIAERTM 232 Query: 440 LSVLDGNCRTPIAAYAYRDKDGNCSFRGLLAS-PDGSIV 327 L G+C P+ AYA + G +GL+ DG +V Sbjct: 233 NRALHGSCHVPVGAYASYEV-GGMRLQGLVGCVADGRLV 270
>HEM3_NEUCR (Q6MW51) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 337 Score = 50.8 bits (120), Expect = 3e-06 Identities = 33/117 (28%), Positives = 50/117 (42%), Gaps = 1/117 (0%) Frame = -2 Query: 569 MLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREFLSVLDGNCRTPIAAYAY 390 ML AV QGA+ + R D+K +E + L HE T +A ER + L+G C PI Sbjct: 204 MLHAVGQGALAMEIREGDEKTLEIIKPLCHEKTMVATFAERAVMRTLEGGCSVPIGVETK 263 Query: 389 RDKDGNCSFRGLLASPDG-SIVYETSRSGTYSFDDMVAIGQDAGHELKSKAGPGFFD 222 + + + S DG V S + ++ A+GQ +L + D Sbjct: 264 WVGEDQLQLKVTVVSLDGKESVDGQSVEVIKTIEEAEAMGQKLAEDLAKRGAQKILD 320
>HEM3_SULSO (Q980U4) Probable porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 293 Score = 49.3 bits (116), Expect = 9e-06 Identities = 37/116 (31%), Positives = 55/116 (47%), Gaps = 2/116 (1%) Frame = -2 Query: 584 LSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREFLSVLDGNCRTPI 405 L+V + P QG I + R D+K+ E + H+DT ER +SV+ G C +PI Sbjct: 178 LNVYDFTPEANQGIIVVLGRKKDEKVKEVFKEITHKDTLDEALAERATISVVGGGCHSPI 237 Query: 404 AAYAYRDKDGNCSFRGLLASPDG--SIVYETSRSGTYSFDDMVAIGQDAGHELKSK 243 +R K+G F G+ + DG I S++G D IG + G LK + Sbjct: 238 GV-LFR-KEGK-EFYGIASYSDGKKKITVSISKAG-----DPYTIGSELGLLLKKE 285
>HEM3_METKA (Q8TXC8) Probable porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 305 Score = 49.3 bits (116), Expect = 9e-06 Identities = 25/82 (30%), Positives = 42/82 (51%) Frame = -2 Query: 617 RLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREFL 438 RL M + V +E +P QGA+ I CR +DD++ L ++ E +R+ V E+ + Sbjct: 182 RLGMTSEVSEVYDPEEFVPPAGQGALMITCRKDDDRVKRLLEVVDDEKSRVEVETEKAVV 241 Query: 437 SVLDGNCRTPIAAYAYRDKDGN 372 L C P+ + R +DG+ Sbjct: 242 RELGVGCSEPVGVHV-RARDGD 262
>HEM3_CAUCR (Q9ABZ8) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 322 Score = 47.4 bits (111), Expect = 3e-05 Identities = 40/131 (30%), Positives = 60/131 (45%), Gaps = 4/131 (3%) Frame = -2 Query: 617 RLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREFL 438 RL + S L D PA QGA+ I R+ +D +L ++ T +AVA ER L Sbjct: 187 RLGLGHLTRSWLDPDACPPAPGQGALVIETRA-EDIGAPWLEAVRCRQTTIAVAAERGAL 245 Query: 437 SVLDGNCRTPIAAYAYRDKDGNCSFRGLLASPDGSIVY----ETSRSGTYSFDDMVAIGQ 270 L+G+CRT I A A D S +PDG+ + + + +G + A G Sbjct: 246 LALEGSCRTAIGARAILD-GARLSMIVEALTPDGAQRFRREGDITLTGADDIAEARAFGL 304 Query: 269 DAGHELKSKAG 237 G E+++ G Sbjct: 305 TLGAEVRAAGG 315
>HEM3_YEAST (P28789) Porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 327 Score = 47.4 bits (111), Expect = 3e-05 Identities = 27/100 (27%), Positives = 44/100 (44%), Gaps = 1/100 (1%) Frame = -2 Query: 617 RLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREFL 438 R+ + T D M AV QGA+GI R D KMM+ L + + + ER + Sbjct: 185 RMGLENRITQRFHSDTMYHAVGQGALGIEIRKGDTKMMKILDEICDLNATICCLSERALM 244 Query: 437 SVLDGNCRTPIAAYA-YRDKDGNCSFRGLLASPDGSIVYE 321 L+G C PI + Y ++ + ++ +G+ E Sbjct: 245 RTLEGGCSVPIGVESKYNEETKKLLLKAIVVDVEGTEAVE 284
>HEM3_METAC (Q8TT56) Probable porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 317 Score = 46.6 bits (109), Expect = 6e-05 Identities = 24/70 (34%), Positives = 38/70 (54%) Frame = -2 Query: 587 VLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREFLSVLDGNCRTP 408 +LS D P+ QG + + R+ D ++ +S L+H ++R+ ER +S L G C TP Sbjct: 179 ILSPDFFCPSPNQGTVAVVTRA-DPEIEAAVSGLDHTESRIVTEIERILISELGGGCTTP 237 Query: 407 IAAYAYRDKD 378 I +YA D Sbjct: 238 IGSYAELTSD 247
>HEM3_SULTO (Q976H1) Probable porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 294 Score = 44.7 bits (104), Expect = 2e-04 Identities = 25/77 (32%), Positives = 40/77 (51%), Gaps = 1/77 (1%) Frame = -2 Query: 563 PAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREFLSVLDGNCRTPIAAYAYR- 387 P QG I + R D+ + + + +N +DT ER+ LS++ G C +PI Y + Sbjct: 185 PEANQGIIVVIGRKKDETIKKIFNEINDKDTLEIAIAERKALSIVGGGCHSPIGVYFEKY 244 Query: 386 DKDGNCSFRGLLASPDG 336 DKD F G+++S G Sbjct: 245 DKD----FHGIISSSFG 257
>HEM3_HALSA (Q9HMY5) Probable porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 396 Score = 43.1 bits (100), Expect = 7e-04 Identities = 23/64 (35%), Positives = 31/64 (48%) Frame = -2 Query: 584 LSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREFLSVLDGNCRTPI 405 LS +PA QGA+ + R + D + +L H TR+ V ER L L G C PI Sbjct: 273 LSTGTHVPATGQGALCVTARRDSDVVDTLRDALEHVRTRVEVTAERVVLEELGGGCIAPI 332 Query: 404 AAYA 393 +A Sbjct: 333 GVHA 336
>HEM3_METMA (Q8PW57) Probable porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 316 Score = 40.4 bits (93), Expect = 0.004 Identities = 20/70 (28%), Positives = 34/70 (48%) Frame = -2 Query: 602 ETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREFLSVLDG 423 E + S D P+ QG + + R + +S L+H ++R+ ER ++ L G Sbjct: 174 EIEGEIFSPDFFCPSPNQGTVAVVTREGTEAEAA-VSMLDHTESRIVTEIERILIAELGG 232 Query: 422 NCRTPIAAYA 393 C TP+ +YA Sbjct: 233 GCTTPVGSYA 242
>HEM3_AERPE (Q9Y9J0) Probable porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 305 Score = 37.7 bits (86), Expect = 0.027 Identities = 34/106 (32%), Positives = 41/106 (38%), Gaps = 2/106 (1%) Frame = -2 Query: 563 PAVAQGAIGIACR--SNDDKMMEYLSSLNHEDTRLAVACEREFLSVLDGNCRTPIAAYAY 390 PA QG + + R SN +KM L L+ ER L CRTP+AAYA Sbjct: 191 PAPGQGFVAVVARVGSNVEKM---LRDLDKPPWWHVAWAERGVLEGARAGCRTPVAAYAE 247 Query: 389 RDKDGNCSFRGLLASPDGSIVYETSRSGTYSFDDMVAIGQDAGHEL 252 SPDGS Y G ++ IG G EL Sbjct: 248 PLGRSMVRVTAAALSPDGSRAYWARAEG--RIEEARRIGVSLGEEL 291
>HEM3_METTH (O26960) Probable porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 289 Score = 37.7 bits (86), Expect = 0.027 Identities = 27/124 (21%), Positives = 54/124 (43%) Frame = -2 Query: 620 KRLHMAETATSVLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREF 441 KRL + E V+ PA QGA+ + R+ D +++ + + H + V E+ Sbjct: 167 KRLGLEEHIKRRFPVEYFTPAAGQGALAVITRA-DSELISSIGRITHHPSLQEVTAEKTL 225 Query: 440 LSVLDGNCRTPIAAYAYRDKDGNCSFRGLLASPDGSIVYETSRSGTYSFDDMVAIGQDAG 261 L L C+ P+ R + +L + +G ++ + + G + + IG+ A Sbjct: 226 LRELGAGCQCPLGVIG-RATGNQLTLYAVLLTREGEMLRKVTVRGPLA--EAEDIGKKAA 282 Query: 260 HELK 249 E++ Sbjct: 283 KEME 286
>SMS2_MOUSE (Q9D4B1) Phosphatidylcholine:ceramide cholinephosphotransferase 2| (EC 2.7.-.-) (Sphingomyelin synthase 2) Length = 365 Score = 32.7 bits (73), Expect = 0.88 Identities = 23/58 (39%), Positives = 27/58 (46%), Gaps = 3/58 (5%) Frame = +1 Query: 112 FKWYSSICGTKFYHNYKKMVKNKINTI-RAWW--IFYCKPSKKPGPAFDFSSWPASWP 276 F WY S+ K N K V ++ N + RAWW IFY G SWP SWP Sbjct: 288 FWWYHSMANEK---NLK--VSSQTNFLSRAWWFPIFYFFEKNVQGSIPCCFSWPLSWP 340
>SMS2_HUMAN (Q8NHU3) Phosphatidylcholine:ceramide cholinephosphotransferase 2| (EC 2.7.-.-) (Sphingomyelin synthase 2) Length = 365 Score = 32.7 bits (73), Expect = 0.88 Identities = 23/58 (39%), Positives = 27/58 (46%), Gaps = 3/58 (5%) Frame = +1 Query: 112 FKWYSSICGTKFYHNYKKMVKNKINTI-RAWW--IFYCKPSKKPGPAFDFSSWPASWP 276 F WY S+ K N K V ++ N + RAWW IFY G SWP SWP Sbjct: 288 FWWYHSMANEK---NLK--VSSQTNFLSRAWWFPIFYFFEKNVQGSIPCCFSWPLSWP 340
>US426_GAHVG (Q05104) Hypothetical 15.7 kDa protein| Length = 142 Score = 32.3 bits (72), Expect = 1.2 Identities = 14/33 (42%), Positives = 17/33 (51%) Frame = +1 Query: 214 CKPSKKPGPAFDFSSWPASWPIATMSSKEYVPL 312 C P + F FSSW P+ TMS+ VPL Sbjct: 46 CLPPFRSSHCFTFSSWALGVPVRTMSNSRVVPL 78
>SRY_MUSSI (Q62565) Sex-determining region Y protein (Testis-determining| factor) Length = 311 Score = 32.0 bits (71), Expect = 1.5 Identities = 13/31 (41%), Positives = 18/31 (58%) Frame = +2 Query: 386 HDKHMPQLEFDSYHQEQTRILFHMQQLIWYL 478 HD H Q +F +H +Q + FH QQL + L Sbjct: 257 HDHHQQQQQFHDHHHQQQQQQFHDQQLTYLL 287
>HEM3_THEAC (Q9HKM5) Probable porphobilinogen deaminase (EC 2.5.1.61) (PBG)| (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) Length = 295 Score = 32.0 bits (71), Expect = 1.5 Identities = 19/57 (33%), Positives = 26/57 (45%) Frame = -2 Query: 575 DEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREFLSVLDGNCRTPI 405 ++ +PA QG I + K E LSS+N DT + ER L C TP+ Sbjct: 183 EKFVPAPNQGIIAVVSEDGS-KASEVLSSINDADTYDDMMAERSITQGLKLGCSTPV 238
>DAPA_STRPN (Q97R25) Dihydrodipicolinate synthase (EC 4.2.1.52) (DHDPS)| Length = 311 Score = 31.6 bits (70), Expect = 2.0 Identities = 13/39 (33%), Positives = 23/39 (58%) Frame = -2 Query: 554 AQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREFL 438 A G I +A +N D+M E +++ D + A A +R+F+ Sbjct: 205 ADGVISVASHTNGDEMHEMFTAIAESDMKKAAAIQRKFI 243
>SRY_MUSSP (Q62563) Sex-determining region Y protein (Testis-determining| factor) Length = 355 Score = 31.2 bits (69), Expect = 2.6 Identities = 22/110 (20%), Positives = 41/110 (37%) Frame = +2 Query: 134 VVQNSIITTRRW*KTKSTLSERGGYSIASHRRNQVQPLISVRGRHLGLSRPCHQKNMFHF 313 V + +W + ++ R +S A+H ++ Q ++ + P Q+ FH Sbjct: 93 VASTKLYNLLQWDRNPHAITYRQDWSRAAHLYSKNQQSFYLQPVDIPTGHPQQQQQQFH- 151 Query: 314 LMSRIL*SHLVKPIAPGMNSSHPCHDKHMPQLEFDSYHQEQTRILFHMQQ 463 +H HD H + +F +HQ+Q + H QQ Sbjct: 152 -------NH--------HQQKQQFHDHHQQKQQFHDHHQQQQQFHDHQQQ 186 Score = 30.8 bits (68), Expect = 3.4 Identities = 13/31 (41%), Positives = 18/31 (58%) Frame = +2 Query: 386 HDKHMPQLEFDSYHQEQTRILFHMQQLIWYL 478 HD H Q +F + Q+Q + FH QQL + L Sbjct: 301 HDHHQQQQQFHDHQQQQQQQQFHDQQLTYLL 331 Score = 30.4 bits (67), Expect = 4.4 Identities = 14/48 (29%), Positives = 24/48 (50%), Gaps = 3/48 (6%) Frame = +2 Query: 386 HDKHMPQLEFDSYHQEQTRILFH---MQQLIWYLHDSKRIDTPSFYHH 520 HD H + +F +HQ+Q + FH QQ ++ H ++ +HH Sbjct: 236 HDHHQQKQQFHDHHQQQQQQQFHDHPQQQQQFHDHPQQKQQFHDHHHH 283
>DAPA_STRR6 (Q8DPZ9) Dihydrodipicolinate synthase (EC 4.2.1.52) (DHDPS)| Length = 311 Score = 30.8 bits (68), Expect = 3.4 Identities = 13/39 (33%), Positives = 22/39 (56%) Frame = -2 Query: 554 AQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREFL 438 A G I +A +N D+M E ++ D + A A +R+F+ Sbjct: 205 ADGVISVASHTNGDEMHEMFIAIAESDVKKAAAIQRKFI 243
>VATE_SPIOL (Q41396) Vacuolar ATP synthase subunit E (EC 3.6.3.14) (V-ATPase E| subunit) (Vacuolar proton pump E subunit) Length = 229 Score = 30.4 bits (67), Expect = 4.4 Identities = 21/88 (23%), Positives = 41/88 (46%) Frame = -2 Query: 578 VDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAVACEREFLSVLDGNCRTPIAA 399 V + L + + + + CR +D ++E++ LN A E ++ + P Sbjct: 118 VVQSLLRLREPGVLLRCREDDVHLVEHV--LNSAKEEYAEKAEVHTPEIIVDSIHLPAGP 175 Query: 398 YAYRDKDGNCSFRGLLASPDGSIVYETS 315 +++ +CS +LAS DG IV+E + Sbjct: 176 SHHKEHGLHCSGGVVLASRDGKIVFENT 203
>AROH_SHIFL (P59736) Phospho-2-dehydro-3-deoxyheptonate aldolase, Trp-sensitive| (EC 2.5.1.54) (Phospho-2-keto-3-deoxyheptonate aldolase) (DAHP synthetase) (3-deoxy-D-arabino-heptulosonate 7-phosphate synthase) Length = 348 Score = 30.0 bits (66), Expect = 5.7 Identities = 22/85 (25%), Positives = 34/85 (40%), Gaps = 9/85 (10%) Frame = -2 Query: 482 HEDTRLAVACEREFLSVLDGNCRTPIAA---------YAYRDKDGNCSFRGLLASPDGSI 330 H + A++C F + DGN R + A + DK+G + +P G I Sbjct: 171 HREMASALSCPVGFKNGTDGNTRIAVDAIRAARASHMFLSPDKNGQMTIYQTSGNPYGHI 230 Query: 329 VYETSRSGTYSFDDMVAIGQDAGHE 255 + + Y DD +A D HE Sbjct: 231 IMRGGKKPNYHADD-IAAACDTLHE 254
>AROH_ECOLI (P00887) Phospho-2-dehydro-3-deoxyheptonate aldolase, Trp-sensitive| (EC 2.5.1.54) (Phospho-2-keto-3-deoxyheptonate aldolase) (DAHP synthetase) (3-deoxy-D-arabino-heptulosonate 7-phosphate synthase) Length = 348 Score = 30.0 bits (66), Expect = 5.7 Identities = 22/85 (25%), Positives = 34/85 (40%), Gaps = 9/85 (10%) Frame = -2 Query: 482 HEDTRLAVACEREFLSVLDGNCRTPIAA---------YAYRDKDGNCSFRGLLASPDGSI 330 H + A++C F + DGN R + A + DK+G + +P G I Sbjct: 171 HREMASALSCPVGFKNGTDGNTRIAVDAIRAARASHMFLSPDKNGQMTIYQTSGNPYGHI 230 Query: 329 VYETSRSGTYSFDDMVAIGQDAGHE 255 + + Y DD +A D HE Sbjct: 231 IMRGGKKPNYHADD-IAAACDTLHE 254
>AROH_ECOL6 (Q8FH32) Phospho-2-dehydro-3-deoxyheptonate aldolase, Trp-sensitive| (EC 2.5.1.54) (Phospho-2-keto-3-deoxyheptonate aldolase) (DAHP synthetase) (3-deoxy-D-arabino-heptulosonate 7-phosphate synthase) Length = 348 Score = 30.0 bits (66), Expect = 5.7 Identities = 22/85 (25%), Positives = 34/85 (40%), Gaps = 9/85 (10%) Frame = -2 Query: 482 HEDTRLAVACEREFLSVLDGNCRTPIAA---------YAYRDKDGNCSFRGLLASPDGSI 330 H + A++C F + DGN R + A + DK+G + +P G I Sbjct: 171 HREMASALSCPVGFKNGTDGNTRIAVDAIRAARASHMFLSPDKNGQMTIYQTSGNPYGHI 230 Query: 329 VYETSRSGTYSFDDMVAIGQDAGHE 255 + + Y DD +A D HE Sbjct: 231 IMRGGKKPNYHADD-IAAACDTLHE 254
>AROH_ECO57 (Q8X5W4) Phospho-2-dehydro-3-deoxyheptonate aldolase, Trp-sensitive| (EC 2.5.1.54) (Phospho-2-keto-3-deoxyheptonate aldolase) (DAHP synthetase) (3-deoxy-D-arabino-heptulosonate 7-phosphate synthase) Length = 348 Score = 30.0 bits (66), Expect = 5.7 Identities = 22/85 (25%), Positives = 34/85 (40%), Gaps = 9/85 (10%) Frame = -2 Query: 482 HEDTRLAVACEREFLSVLDGNCRTPIAA---------YAYRDKDGNCSFRGLLASPDGSI 330 H + A++C F + DGN R + A + DK+G + +P G I Sbjct: 171 HREMASALSCPVGFKNGTDGNTRIAVDAIRAARASHMFLSPDKNGQMTIYQTSGNPYGHI 230 Query: 329 VYETSRSGTYSFDDMVAIGQDAGHE 255 + + Y DD +A D HE Sbjct: 231 IMRGGKKPNYHADD-IAAACDTLHE 254
>ACKA2_NEIMB (Q9K0X1) Acetate kinase 2 (EC 2.7.2.1) (Acetokinase 2)| Length = 399 Score = 30.0 bits (66), Expect = 5.7 Identities = 18/43 (41%), Positives = 25/43 (58%) Frame = -2 Query: 587 VLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAV 459 V VDEML + G +GI+ SND + +E + HE RLA+ Sbjct: 259 VAQVDEMLNKKS-GLLGISELSNDCRTLEIAADEGHEGARLAL 300
>ACKA2_NEIMA (Q9JT07) Acetate kinase 2 (EC 2.7.2.1) (Acetokinase 2)| Length = 399 Score = 30.0 bits (66), Expect = 5.7 Identities = 18/43 (41%), Positives = 25/43 (58%) Frame = -2 Query: 587 VLSVDEMLPAVAQGAIGIACRSNDDKMMEYLSSLNHEDTRLAV 459 V VDEML + G +GI+ SND + +E + HE RLA+ Sbjct: 259 VAQVDEMLNKKS-GLLGISELSNDCRTLEIAADEGHEGARLAL 300
>AROH_BUCAI (P57224) Phospho-2-dehydro-3-deoxyheptonate aldolase, Trp-sensitive| (EC 2.5.1.54) (Phospho-2-keto-3-deoxyheptonate aldolase) (DAHP synthetase) (3-deoxy-D-arabino-heptulosonate 7-phosphate synthase) Length = 348 Score = 29.6 bits (65), Expect = 7.5 Identities = 20/75 (26%), Positives = 31/75 (41%), Gaps = 9/75 (12%) Frame = -2 Query: 482 HEDTRLAVACEREFLSVLDGNCRTPIAA---------YAYRDKDGNCSFRGLLASPDGSI 330 H + A++C F + DGN R I A + +KDG + +P G I Sbjct: 171 HREMASALSCPVGFKNGTDGNIRIAIDAIRAAKVRHLFFAPNKDGQMTINHTSGNPYGHI 230 Query: 329 VYETSRSGTYSFDDM 285 + R+ Y DD+ Sbjct: 231 IMRGGRAPNYHPDDI 245
>PRTD_STRGR (P52321) Serine protease D precursor (EC 3.4.21.-) (SGPD)| Length = 392 Score = 29.3 bits (64), Expect = 9.8 Identities = 14/36 (38%), Positives = 21/36 (58%) Frame = +2 Query: 218 SHRRNQVQPLISVRGRHLGLSRPCHQKNMFHFLMSR 325 S RRN +P++ VR HL +RP + + H +SR Sbjct: 4 SRRRNSGRPILRVRAPHLLRARPHRRSKLKHRRISR 39
>YEGK_ECOLI (P76395) Hypothetical protein yegK| Length = 253 Score = 29.3 bits (64), Expect = 9.8 Identities = 15/50 (30%), Positives = 25/50 (50%) Frame = -2 Query: 383 KDGNCSFRGLLASPDGSIVYETSRSGTYSFDDMVAIGQDAGHELKSKAGP 234 +D C+F GL++SPDG+++ + G + D GH L+ P Sbjct: 108 RDFACTFLGLISSPDGTLIMQIGDGG---------VVVDLGHGLQLPLTP 148 Database: uniprot_sprot.fasta Posted date: May 25, 2006 5:36 PM Number of letters in database: 80,573,946 Number of sequences in database: 219,361 Lambda K H 0.318 0.135 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 89,184,191 Number of Sequences: 219361 Number of extensions: 1889903 Number of successful extensions: 5108 Number of sequences better than 10.0: 158 Number of HSP's better than 10.0 without gapping: 4917 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 5063 length of database: 80,573,946 effective HSP length: 107 effective length of database: 57,102,319 effective search space used: 5653129581 frameshift window, decay const: 50, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)
