>DCNL4_BRARE (Q5RHX6) DCN1-like protein 4 (Defective in cullin neddylation|
           protein 1-like protein 4) (DCUN1 domain-containing
           protein 4)
          Length = 280

 Score = 64.3 bits (155), Expect = 3e-10
 Identities = 34/88 (38%), Positives = 49/88 (55%)
 Frame = -3

Query: 589 EDKKKCIEIPVACELLNLVLSLQFRPQVEKLINYLKHQNEYKVINMDQWMGFLRFCNEIN 410
           E  ++ +++  A  +L L+L   +   +  + N    Q++YKVIN DQW   L F   IN
Sbjct: 194 EKDQRSLDLNTAKCMLGLLLGKTW--PLFPVFNQFLEQSKYKVINKDQWCNVLEFSRTIN 251

Query: 409 FPSLDNYDADQAWPLILDNFVEWLRANE 326
              L NYD D AWP++LD FVEW +  E
Sbjct: 252 L-DLSNYDEDGAWPVLLDEFVEWYKDRE 278

>DCNL4_HUMAN (Q92564) DCN1-like protein 4 (Defective in cullin neddylation|
           protein 1-like protein 4) (DCUN1 domain-containing
           protein 4)
          Length = 292

 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 35/85 (41%), Positives = 49/85 (57%)
 Frame = -3

Query: 589 EDKKKCIEIPVACELLNLVLSLQFRPQVEKLINYLKHQNEYKVINMDQWMGFLRFCNEIN 410
           E  ++ ++I  A  +L L+L  +  P       +L+ Q++YKVIN DQW   L F   IN
Sbjct: 206 EKDQRSLDINTAKCMLGLLLG-KIWPLFPVFHQFLE-QSKYKVINKDQWCNVLEFSRTIN 263

Query: 409 FPSLDNYDADQAWPLILDNFVEWLR 335
              L NYD D AWP++LD FVEW +
Sbjct: 264 L-DLSNYDEDGAWPVLLDEFVEWYK 287

>DCNL4_MOUSE (Q8CCA0) DCN1-like protein 4 (Defective in cullin neddylation|
           protein 1-like protein 4) (DCUN1 domain-containing
           protein 4)
          Length = 292

 Score = 60.1 bits (144), Expect = 5e-09
 Identities = 34/85 (40%), Positives = 49/85 (57%)
 Frame = -3

Query: 589 EDKKKCIEIPVACELLNLVLSLQFRPQVEKLINYLKHQNEYKVINMDQWMGFLRFCNEIN 410
           E  ++ ++I  A  +L L+L  +  P       +L+ Q++YKVIN DQW   L F   I+
Sbjct: 206 EKDQRSLDINTAKCMLGLLLG-KIWPLFPVFHQFLE-QSKYKVINKDQWCNVLEFSRTIS 263

Query: 409 FPSLDNYDADQAWPLILDNFVEWLR 335
              L NYD D AWP++LD FVEW +
Sbjct: 264 L-DLSNYDEDGAWPVLLDEFVEWYK 287

>DCN1_USTMA (Q4PF67) Defective in cullin neddylation protein 1|
          Length = 319

 Score = 53.5 bits (127), Expect = 5e-07
 Identities = 25/61 (40%), Positives = 35/61 (57%)
 Frame = -3

Query: 511 QVEKLINYLKHQNEYKVINMDQWMGFLRFCNEINFPSLDNYDADQAWPLILDNFVEWLRA 332
           Q++    +L  Q   + ++ D WM FL F  EIN     N+D D AWP I+D+FV W+R 
Sbjct: 250 QLDLWKRFLSEQTRGRAVSKDTWMQFLDFTKEIN-SDFSNHDFDAAWPSIIDDFVLWVRD 308

Query: 331 N 329
           N
Sbjct: 309 N 309

>DCN1L_DROME (Q9VUQ8) DCN1-like protein (Defective in cullin neddylation protein|
           1-like protein)
          Length = 288

 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 26/86 (30%), Positives = 53/86 (61%)
 Frame = -3

Query: 580 KKCIEIPVACELLNLVLSLQFRPQVEKLINYLKHQNEYKVINMDQWMGFLRFCNEINFPS 401
           +K I++ +A     +VLS +F+  ++    +L+ +++ + I+ D W   L F   I+   
Sbjct: 166 QKGIDLEMAIAYWCIVLSGRFK-FLDIWCQFLEEKHK-RAISRDTWNLLLDFATNID-DR 222

Query: 400 LDNYDADQAWPLILDNFVEWLRANEN 323
           + NYD++ AWP+++D+FVEW + N++
Sbjct: 223 MSNYDSEGAWPVLIDDFVEWCQENDH 248

>DCNL2_MOUSE (Q8BZJ7) DCN1-like protein 2 (Defective in cullin neddylation|
           protein 2-like protein 2) (DCUN1 domain-containing
           protein 2)
          Length = 258

 Score = 42.7 bits (99), Expect = 8e-04
 Identities = 28/82 (34%), Positives = 46/82 (56%)
 Frame = -3

Query: 580 KKCIEIPVACELLNLVLSLQFRPQVEKLINYLKHQNEYKVINMDQWMGFLRFCNEINFPS 401
           +K +++ +A     LVLS +F+  ++    +L+H    + I  D W   L F N I    
Sbjct: 170 QKGLDLEMAVAYWKLVLSGRFK-FLDLWNTFLEHHK--RSIPRDTWNLLLDFGNMIA-DD 225

Query: 400 LDNYDADQAWPLILDNFVEWLR 335
           L NYD + AWP+++D+FVE+ R
Sbjct: 226 LSNYDEEGAWPVLIDDFVEYAR 247

>DCNL2_HUMAN (Q6PH85) DCN1-like protein 2 (Defective in cullin neddylation|
           protein 2-like protein 2) (DCUN1 domain-containing
           protein 2)
          Length = 259

 Score = 42.0 bits (97), Expect = 0.001
 Identities = 27/82 (32%), Positives = 44/82 (53%)
 Frame = -3

Query: 580 KKCIEIPVACELLNLVLSLQFRPQVEKLINYLKHQNEYKVINMDQWMGFLRFCNEINFPS 401
           +K +++ +A     LVLS +F+     L N    ++  + I  D W   L F N I    
Sbjct: 170 QKGLDLEMAVAYWKLVLSGRFK--FLDLWNTFLMEHHKRSIPRDTWNLLLDFGNMIA-DD 226

Query: 400 LDNYDADQAWPLILDNFVEWLR 335
           + NYD + AWP+++D+FVE+ R
Sbjct: 227 MSNYDEEGAWPVLIDDFVEYAR 248

>DCNL1_MOUSE (Q9QZ73) DCN1-like protein 1 (Defective in cullin neddylation|
           protein 1-like protein 1) (DCUN1 domain-containing
           protein 1) (Testis-specific protein 3)
          Length = 259

 Score = 41.2 bits (95), Expect = 0.002
 Identities = 26/82 (31%), Positives = 45/82 (54%)
 Frame = -3

Query: 580 KKCIEIPVACELLNLVLSLQFRPQVEKLINYLKHQNEYKVINMDQWMGFLRFCNEINFPS 401
           +K +++ +A    NLVL+ +F+     L N    ++  + I  D W   L F + I    
Sbjct: 170 QKGLDLEMAIAYWNLVLNGRFK--FLDLWNKFLLEHHKRSIPKDTWNLLLDFSSMIA-DD 226

Query: 400 LDNYDADQAWPLILDNFVEWLR 335
           + NYD + AWP+++D+FVE+ R
Sbjct: 227 MSNYDEEGAWPVLIDDFVEFAR 248

>DCNL1_HUMAN (Q96GG9) DCN1-like protein 1 (Defective in cullin neddylation|
           protein 1-like protein 1) (DCUN1 domain-containing
           protein 1) (Squamous cell carcinoma-related oncogene)
          Length = 259

 Score = 40.8 bits (94), Expect = 0.003
 Identities = 26/82 (31%), Positives = 44/82 (53%)
 Frame = -3

Query: 580 KKCIEIPVACELLNLVLSLQFRPQVEKLINYLKHQNEYKVINMDQWMGFLRFCNEINFPS 401
           +K +++ +A    NLVL+ +F+     L N    ++  + I  D W   L F   I    
Sbjct: 170 QKGLDLEMAIAYWNLVLNGRFK--FLDLWNKFLLEHHKRSIPKDTWNLLLDFSTMIA-DD 226

Query: 400 LDNYDADQAWPLILDNFVEWLR 335
           + NYD + AWP+++D+FVE+ R
Sbjct: 227 MSNYDEEGAWPVLIDDFVEFAR 248

>DCNL1_CHICK (Q5ZKU1) DCN1-like protein 1 (Defective in cullin neddylation|
           protein 1-like protein 1) (DCUN1 domain-containing
           protein 1)
          Length = 259

 Score = 40.8 bits (94), Expect = 0.003
 Identities = 26/82 (31%), Positives = 44/82 (53%)
 Frame = -3

Query: 580 KKCIEIPVACELLNLVLSLQFRPQVEKLINYLKHQNEYKVINMDQWMGFLRFCNEINFPS 401
           +K +++ +A    NLVL+ +F+     L N    ++  + I  D W   L F   I    
Sbjct: 170 QKGLDLEMAIAYWNLVLNGRFK--FLDLWNKFLLEHHKRSIPKDTWNLLLDFSTMIA-DD 226

Query: 400 LDNYDADQAWPLILDNFVEWLR 335
           + NYD + AWP+++D+FVE+ R
Sbjct: 227 MSNYDEEGAWPVLIDDFVEFAR 248

>DCN1_CRYNE (Q5KHV1) Defective in cullin neddylation protein 1|
          Length = 279

 Score = 40.4 bits (93), Expect = 0.004
 Identities = 19/61 (31%), Positives = 35/61 (57%)
 Frame = -3

Query: 517 RPQVEKLINYLKHQNEYKVINMDQWMGFLRFCNEINFPSLDNYDADQAWPLILDNFVEWL 338
           +P+ +  I +++ +N  K ++ D W   + F   I+      YD D AWP ++D+FVE++
Sbjct: 216 QPEFDLWIEFMQQKN--KAVSKDTWALLVDFARGID-KDFKEYDEDGAWPSMIDDFVEYV 272

Query: 337 R 335
           R
Sbjct: 273 R 273

>DCN1_CAEEL (Q9U3C8) Defective in cullin neddylation protein 1|
          Length = 295

 Score = 39.7 bits (91), Expect = 0.007
 Identities = 19/48 (39%), Positives = 29/48 (60%)
 Frame = -3

Query: 460 INMDQWMGFLRFCNEINFPSLDNYDADQAWPLILDNFVEWLRANEN*P 317
           I+ D W  F  F   ++ P L +YD + AWP+++D FV++ R N N P
Sbjct: 232 ISRDTWNLFWDFIL-LSKPDLSDYDDEGAWPVLIDQFVDYCRENLNYP 278

>DCN1_YARLI (Q6C0B6) Defective in cullin neddylation protein 1|
          Length = 240

 Score = 38.9 bits (89), Expect = 0.012
 Identities = 22/88 (25%), Positives = 50/88 (56%), Gaps = 1/88 (1%)
 Frame = -3

Query: 595 LTEDKKKCIEIPVACELLNLVLSLQFRPQVEKLINYLKHQNEYKVINMDQWMGFLRFCN- 419
           L ++ ++ +    A +   L+L+ ++   ++K ++++  + + + I+ D W     F   
Sbjct: 154 LLQEGQRVLPQETAVDYWRLLLTGKYE-HLDKWLSFVTEKYK-RNISRDAWNMLYEFMLF 211

Query: 418 EINFPSLDNYDADQAWPLILDNFVEWLR 335
           +   PSL++YD D AWP ++D +VE+L+
Sbjct: 212 QAKDPSLESYDEDGAWPSVIDEYVEFLK 239

>DCN1_SCHPO (Q8WZK4) Defective in cullin neddylation protein 1|
          Length = 251

 Score = 38.5 bits (88), Expect = 0.015
 Identities = 29/94 (30%), Positives = 44/94 (46%), Gaps = 3/94 (3%)
 Frame = -3

Query: 607 FRYCLTEDK-KKCIEIPVACELLNLVLSLQFRPQVEKLINYLKHQNEY-KVINMDQWMGF 434
           + Y L  DK KK +   +A E   ++L   F P ++  I +LK      K +  D W   
Sbjct: 150 YTYPLACDKGKKTLSTSIAIEFFQILLKDTF-PLLDDWIAFLKVSPIIEKSLPKDTWNEL 208

Query: 433 LRFCNEINF-PSLDNYDADQAWPLILDNFVEWLR 335
             F   +   P+  NYD + AWP ++D FV + R
Sbjct: 209 WDFSVFVKSDPNCSNYDFEGAWPTLIDEFVSYYR 242

>DCN1_CANAL (Q5ADL9) Defective in cullin neddylation protein 1|
          Length = 304

 Score = 36.2 bits (82), Expect = 0.077
 Identities = 30/112 (26%), Positives = 50/112 (44%), Gaps = 22/112 (19%)
 Frame = -3

Query: 607 FRYCLTEDKKKCIEIPVACELLNLVLSL-------------QFRPQV-EKLINYLKH--Q 476
           F++ L  + +K +++  A E   L+L +             +F+  V E++  + K    
Sbjct: 187 FKFSLETESQKFLDLDTAIEYWKLLLPIITETYSKDNKLDEEFKNHVNERVEQWFKFLTD 246

Query: 475 NEY---KVINMDQWMGFLRFCNEINFPS---LDNYDADQAWPLILDNFVEWL 338
            EY   K I+ D W  F  F  EI         +YD   AWP ++D F+E+L
Sbjct: 247 TEYMTKKSISYDSWSMFYLFFKEIVLIDPIKFKDYDEMAAWPSVVDEFLEYL 298

>DCN1_CAEBR (Q60YT5) Defective in cullin neddylation protein 1|
          Length = 292

 Score = 35.4 bits (80), Expect = 0.13
 Identities = 19/52 (36%), Positives = 26/52 (50%)
 Frame = -3

Query: 460 INMDQWMGFLRFCNEINFPSLDNYDADQAWPLILDNFVEWLRANEN*PSCTR 305
           I  D W  F  F   +    L +YD + AWP+++D FV+  R N N P   R
Sbjct: 230 ITRDTWNLFWDFI-VLGKEDLSDYDEEGAWPVLIDQFVDHCRENLNYPKPLR 280

>DCN1_MAGGR (Q52DM9) Defective in cullin neddylation protein 1|
          Length = 281

 Score = 35.0 bits (79), Expect = 0.17
 Identities = 19/53 (35%), Positives = 29/53 (54%), Gaps = 1/53 (1%)
 Frame = -3

Query: 490 YLKHQNEYKVINMDQWMGFLRFCNEINFPS-LDNYDADQAWPLILDNFVEWLR 335
           YLK+ N  + ++ D W   L F  +    S L  +  + +WP ++D FVEWLR
Sbjct: 216 YLKN-NWSRTVSKDMWNQTLDFAVKSTADSTLSFWTPEGSWPSVIDGFVEWLR 267

>DCN1_CANGA (Q6FJR2) Defective in cullin neddylation protein 1|
          Length = 273

 Score = 35.0 bits (79), Expect = 0.17
 Identities = 21/52 (40%), Positives = 29/52 (55%), Gaps = 5/52 (9%)
 Frame = -3

Query: 478 QNEYK-VINMDQWMGFLRFCNEINFPSLD----NYDADQAWPLILDNFVEWL 338
           Q+E+K +I+ D W   L F  +  FPSLD     Y+   AWP  +D F E+L
Sbjct: 218 QDEHKKLIHKDTWQMLLLFFKK--FPSLDAIKTEYNEADAWPYTIDEFYEYL 267

>DCN1_ASHGO (Q750Y3) Defective in cullin neddylation protein 1|
          Length = 256

 Score = 33.9 bits (76), Expect = 0.38
 Identities = 15/46 (32%), Positives = 26/46 (56%), Gaps = 4/46 (8%)
 Frame = -3

Query: 460 INMDQWMGFLRFCNEINFPS----LDNYDADQAWPLILDNFVEWLR 335
           ++ D W  F RF     FP     L++Y+   +WPL++D + EW++
Sbjct: 208 VSRDTWDMFPRFAQR--FPDDTELLEHYNELASWPLVIDEYYEWVK 251

>DCN1_EMENI (Q5AWS1) Defective in cullin neddylation protein 1|
          Length = 308

 Score = 32.0 bits (71), Expect = 1.4
 Identities = 26/103 (25%), Positives = 47/103 (45%), Gaps = 12/103 (11%)
 Frame = -3

Query: 607 FRYCLTEDKKKCIEIPVACELLNLVLSLQ---------FRPQVEKLINYLKHQNEYKVIN 455
           F  CL + ++  ++  +A E  NL  +             P ++  + +L+ + + K +N
Sbjct: 199 FPLCLVQGQRN-LQFEIAVEQWNLFFTTPKGGIAWNTTTTPWLDWWVEFLEERGK-KPVN 256

Query: 454 MDQWMG---FLRFCNEINFPSLDNYDADQAWPLILDNFVEWLR 335
            D W     F+R  +E    +   +  D AWP  LD+FV W+R
Sbjct: 257 KDLWQQVEVFMRKTHEDE--AFGWWSEDGAWPGTLDDFVAWVR 297

>ZFY16_MOUSE (Q80U44) Zinc finger FYVE domain-containing protein 16 (Endofin)|
            (Endosomal-associated FYVE domain protein)
          Length = 1528

 Score = 31.6 bits (70), Expect = 1.9
 Identities = 19/55 (34%), Positives = 26/55 (47%)
 Frame = -3

Query: 301  VVKMQSKCNTQKSPWRILEDADQARL*LLCSESGFRNYQSPCSLLFTFFILETLS 137
            +V+ Q+ C  Q  P   L D D A + ++    G  N   P  +   FFILE LS
Sbjct: 1475 MVEFQAGCEGQLLPQHYLNDLDSALIPVI--HGGTSNSSLPLEIELAFFILENLS 1527

>TAXB1_RAT (Q66HA4) Tax1-binding protein 1 homolog (Liver regeneration-related|
           protein LRRG004)
          Length = 813

 Score = 30.4 bits (67), Expect = 4.2
 Identities = 16/41 (39%), Positives = 22/41 (53%)
 Frame = +2

Query: 32  FKTSRKLHALETTHLQSH*KYKYRECRHKILDDDPAKCFKY 154
           F  S K H  E T   +    KY +C+ ++L D+ AKC KY
Sbjct: 517 FDMSAKDHVCEVTKEMAEKVEKYNKCK-QLLQDEKAKCNKY 556

>HANG_DROME (Q9VXG1) Zinc finger protein hangover|
          Length = 1959

 Score = 30.0 bits (66), Expect = 5.5
 Identities = 18/44 (40%), Positives = 21/44 (47%), Gaps = 2/44 (4%)
 Frame = +2

Query: 8    EQHMPTCSFK--TSRKLHALETTHLQSH*KYKYRECRHKILDDD 133
            + H PTC+ K  TS   H  +   L SH   K    RHK  DDD
Sbjct: 1230 DNHTPTCNRKPITSTGAHQQQDGQLHSHHTAKRTIFRHKTGDDD 1273

>DCN1_YEAST (Q12395) Defective in cullin neddylation protein 1|
          Length = 269

 Score = 30.0 bits (66), Expect = 5.5
 Identities = 18/62 (29%), Positives = 30/62 (48%), Gaps = 4/62 (6%)
 Frame = -3

Query: 508 VEKLINYLKHQNEYKVINMDQWMGFLRFCNEINFPSLD----NYDADQAWPLILDNFVEW 341
           +E    +L+ + +   I+ D W   L F     +P++     +YD   AWP I+D F E 
Sbjct: 208 LEAWFRFLRDEGK-TTISKDTWRMLLLFFKR--YPTIQKIISDYDETAAWPFIIDEFYEC 264

Query: 340 LR 335
           L+
Sbjct: 265 LQ 266

>PRP16_HUMAN (Q92620) Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16|
           (EC 3.6.1.-) (ATP-dependent RNA helicase DHX38) (DEAH
           box protein 38)
          Length = 1227

 Score = 29.6 bits (65), Expect = 7.2
 Identities = 22/67 (32%), Positives = 29/67 (43%)
 Frame = +2

Query: 8   EQHMPTCSFKTSRKLHALETTHLQSH*KYKYRECRHKILDDDPAKCFKYKKSEKQTTRRL 187
           E   PT S++ S + H L T       + + R  R K  DD P     YK +E    RR 
Sbjct: 231 ESPSPTPSYRDSERSHRLST-------RDRDRSVRGKYSDDTPLPTPSYKYNEWADDRRH 283

Query: 188 IISKTRL 208
           + S  RL
Sbjct: 284 LGSTPRL 290

>CBBYP_RALEU (Q04541) Protein cbbY, plasmid|
          Length = 254

 Score = 29.3 bits (64), Expect = 9.4
 Identities = 11/23 (47%), Positives = 16/23 (69%)
 Frame = -1

Query: 288 NLNAILRNHLGEFWRMQIKLVCD 220
           NL+A+L+ HLG  WR +   +CD
Sbjct: 125 NLDALLQAHLGADWRGRFAAICD 147


  Database: uniprot_sprot.fasta
    Posted date:  May 25, 2006  5:36 PM
  Number of letters in database: 80,573,946
  Number of sequences in database:  219,361
  
Lambda     K      H
   0.318    0.135    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 82,201,461
Number of Sequences: 219361
Number of extensions: 1597734
Number of successful extensions: 3587
Number of sequences better than 10.0: 26
Number of HSP's better than 10.0 without gapping: 3512
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3583
length of database: 80,573,946
effective HSP length: 107
effective length of database: 57,102,319
effective search space used: 5424720305
frameshift window, decay const: 50,  0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)