ナショナルバイオリソースプロジェクト
-Barley Genetic Resources Database-
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更新日：2016年5月1日

Clone Information

BLAST Search Result

Clone Name rbags26c22
Clone Library Name barley_pub
No. Definition Score
(bits)		 E
Value
1DRTS_MAIZE (O81395) Bifunctional dihydrofolate reductase-thymidy... 342 5e-94
2DRTS2_ARATH (Q05763) Bifunctional dihydrofolate reductase-thymid... 325 7e-89
3DRTS1_ARATH (Q05762) Bifunctional dihydrofolate reductase-thymid... 321 1e-87
4DRTS_SOYBN (P51820) Bifunctional dihydrofolate reductase-thymidy... 318 6e-87
5DRTS_DAUCA (P45350) Bifunctional dihydrofolate reductase-thymidy... 300 3e-81
6TYSY_PNECA (P13100) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 253 3e-67
7TYSY_MOUSE (P07607) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 251 1e-66
8TYSY_RAT (P45352) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 249 6e-66
9TYSY_HUMAN (P04818) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 248 8e-66
10DRTS_PLACH (P20712) Bifunctional dihydrofolate reductase-thymidy... 247 2e-65
11DRTS_PARTE (Q27828) Bifunctional dihydrofolate reductase-thymidy... 246 4e-65
12TYSY_YEAST (P06785) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 246 5e-65
13TYSY_DROME (O76511) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 246 5e-65
14TYSY_HHV8 (P90463) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 246 5e-65
15TYSY_EHV2 (Q89940) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 243 3e-64
16TYSY_HSVAT (P12462) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 239 5e-63
17DRTS_TOXGO (Q07422) Bifunctional dihydrofolate reductase-thymidy... 238 8e-63
18DRTS_PLAVI (O02604) Bifunctional dihydrofolate reductase-thymidy... 238 1e-62
19DRTS_PLABA (Q27713) Bifunctional dihydrofolate reductase-thymidy... 237 2e-62
20DRTS_PLAFK (P13922) Bifunctional dihydrofolate reductase-thymidy... 236 3e-62
21TYSY_SHV21 (P06854) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 234 1e-61
22TYSY_CANAL (P12461) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 231 1e-60
23TYSY_ASCSU (O96650) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 231 1e-60
24TYSY_VZVD (P09249) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 225 1e-58
25DRTS_TRYBB (Q27783) Bifunctional dihydrofolate reductase-thymidy... 225 1e-58
26TYSY_AGABI (Q9P4T7) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 223 3e-58
27DRTS_TRYCR (Q27793) Bifunctional dihydrofolate reductase-thymidy... 222 8e-58
28TYSY_CRYNE (P45351) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 220 3e-57
29TYS1_ENCCU (O62584) Thymidylate synthase 1/2 (EC 2.1.1.45) (TS 1... 219 4e-57
30TYS3_ENCCU (Q8SRG2) Thymidylate synthase 3 (EC 2.1.1.45) (TS 3) ... 219 5e-57
31DRTS_LEIAM (P16126) Bifunctional dihydrofolate reductase-thymidy... 215 8e-56
32DRTS_LEIMA (P07382) Bifunctional dihydrofolate reductase-thymidy... 214 1e-55
33TYSY_CHRVO (Q7NZ95) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 208 1e-53
34TYSY_BRAJA (Q89G35) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 207 2e-53
35TYSY_RHOPA (Q6N447) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 205 8e-53
36TYSY_NEIMB (Q9JY72) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 204 2e-52
37TYSY_NEIMA (Q9JT57) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 203 4e-52
38TYSY_NEIGO (O33380) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 202 9e-52
39TYSY_METFL (Q9RAM7) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 199 4e-51
40TYSY_BDEBA (Q6MID2) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 199 6e-51
41TYSY_BACHD (Q9K7B5) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 195 1e-49
42TYSY_BACHK (Q6HJC7) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 194 2e-49
43TYSY_BACCZ (Q63BV5) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 194 2e-49
44TYSY_BACCR (Q81E05) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 194 2e-49
45TYSY_BACC1 (Q738X7) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 194 2e-49
46TYSY_BACAN (Q81R23) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 194 2e-49
47DRTS_CRIFA (Q23695) Bifunctional dihydrofolate reductase-thymidy... 194 2e-49
48TYSY_ENTFA (Q834R3) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 192 9e-49
49TYSY_BARHE (Q6G2S8) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 191 2e-48
50TYSY_BACSK (Q5WDS1) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 190 3e-48
51TYSY_BACFR (Q64PV5) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 190 3e-48
52TYSY_NITEU (Q82WU3) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 189 4e-48
53TYSY_BRUSU (P67043) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 189 6e-48
54TYSY_BRUME (P67042) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 189 6e-48
55TYSY_LACCA (P00469) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 189 8e-48
56TYSY_RHILO (Q98KH9) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 188 1e-47
57TYSY_PSEAE (Q9I6F1) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 188 1e-47
58TYSY_BACTN (Q8A639) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 187 2e-47
59TYSY_RHIME (Q92NQ5) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 186 6e-47
60TYSY_ACIAD (Q6FER7) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 185 8e-47
61TYSY_LACPL (Q88W05) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 185 8e-47
62TYSY_XYLFA (Q9PB13) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 184 1e-46
63TYSY_RHOBA (Q7UID0) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 183 3e-46
64TYSY_OCEIH (Q8EQG0) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 182 9e-46
65TYSY_MYCMO (Q6KIQ6) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 181 1e-45
66TYSY_STAAW (P67048) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 181 2e-45
67TYSY_STAAS (Q6G9D4) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 181 2e-45
68TYSY_STAAR (Q6GGY0) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 181 2e-45
69TYSY_STAAN (P67047) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 181 2e-45
70TYSY_STAAM (P67046) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 181 2e-45
71TYSY_STAAC (Q5HFZ6) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 181 2e-45
72TYSY_XYLFT (Q87BT4) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 180 3e-45
73TYSY_AGRT5 (Q8UDS3) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 180 3e-45
74TYSY_MYCGA (Q9XC19) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 180 3e-45
75TYSY_BARQU (Q6FZ91) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 180 4e-45
76TYSY_SHEON (Q8EH94) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 178 1e-44
77TYSY_XANCP (Q8PCE7) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 178 1e-44
78TYSY_ONYPE (Q6YQT0) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 177 2e-44
79TYSY_XANAC (Q8PP46) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 177 2e-44
80TYSY_PORGI (Q7MTB5) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 177 3e-44
81TYSY_AZOSE (Q5P233) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 177 3e-44
82TYSY_LACAC (Q5FKL6) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 176 4e-44
83TYSY_CAUCR (Q9A6H0) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 176 5e-44
84TYSB_BACSU (P11044) Thymidylate synthase B (EC 2.1.1.45) (TS B) ... 176 7e-44
85TYSY_XANOR (Q5GWB5) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 175 9e-44
86TYSB_BACAM (P54081) Thymidylate synthase B (EC 2.1.1.45) (TS B) ... 175 1e-43
87TYSY_ECOLI (P0A884) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 174 1e-43
88TYSY_ECOL6 (P0A885) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 174 1e-43
89TYSY_ECO57 (P0A886) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 174 1e-43
90TYSY_COREF (Q8FR47) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 174 2e-43
91TYSY_SHIFL (P48464) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 174 2e-43
92TYSY_YERPS (Q667F9) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 174 3e-43
93TYSY_STAES (P0C0M5) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 174 3e-43
94TYSY_STAEQ (Q5HMP6) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 174 3e-43
95TYSY_STAAU (P0A0M5) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 174 3e-43
96TYSY_BIFLO (Q8G3T9) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 174 3e-43
97TYSY_LISMO (Q8Y626) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 173 3e-43
98TYSY_YERPE (Q8ZHV1) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 173 3e-43
99TYSY_LISIN (Q92AD4) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 173 4e-43
100TYSY_LISMF (Q71YE1) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 172 6e-43
101TYSY_RALSO (Q8Y0U6) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 172 6e-43
102TYSY_MYCPN (P78029) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 172 7e-43
103TYSY_PHOLL (Q7N8U4) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 172 1e-42
104TYSY_ERWCT (Q6D8I6) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 171 1e-42
105TYSY_SALTY (Q8ZMA9) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 171 2e-42
106TYSY_SALTI (Q8Z412) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 171 2e-42
107TYSY_SALPA (Q5PEN6) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 171 2e-42
108TYSY_LEGPL (Q5WSU5) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 169 5e-42
109TYSY_MYCPE (Q8EV81) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 169 5e-42
110TYSY_LEIXX (Q6AFI0) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 169 8e-42
111TYSY_LEGPA (Q5X119) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 169 8e-42
112TYSY_LEGPH (Q5ZRL3) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 168 1e-41
113TYSY_CORDI (Q6NIF2) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 168 1e-41
114TYSY_CORGL (Q8NS38) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 168 1e-41
115TYSY_PROAC (Q6A761) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 167 2e-41
116TYSY_NOCFA (Q5YPL7) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 167 2e-41
117TYSY_MYCTU (P67044) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 166 4e-41
118TYSY_MYCBO (P67045) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 166 4e-41
119TYSY_XENNE (Q6REU8) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 166 4e-41
120TYSY_FRATT (Q5NFK5) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 165 1e-40
121TYSY_GEOKA (Q5KZ25) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 165 1e-40
122TYSY_COXBU (Q83BG2) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 164 2e-40
123TYSY_LACJO (Q74IU3) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 164 2e-40
124TYSY_MYCPA (Q73VZ2) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 164 3e-40
125TYSY_MYCPU (Q98Q31) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 161 2e-39
126TYSY_MYCLE (Q9CBW0) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 160 4e-39
127TYSY_MESFL (Q6F145) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 159 7e-39
128TYSY_BUCBP (P59427) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 159 9e-39
129TYSY_BUCAI (P57515) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 158 1e-38
130TYSY_BUCAP (Q8K9C3) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 155 7e-38
131TYSY_MYCGE (P47469) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 154 2e-37
132TYSY_BPT4 (P00471) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 151 2e-36
133DRTS_MIMIV (Q5UQG3) Bifunctional dihydrofolate reductase-thymidy... 149 9e-36
134TYSY_SYMTH (Q67JQ1) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 144 2e-34
135TYSY_WIGBR (Q8D2N4) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 142 6e-34
136TYSY_ZYMMO (Q9Z671) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 142 1e-33
137TYSY_CLOAB (Q97EV3) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 141 1e-33
138TYSY_METCA (Q603S2) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 138 1e-32
139TYSY_BPPHT (P07606) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 133 5e-31
140TYSY_BACNA (Q5D189) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 132 1e-30
141TYSY_BACMO (Q9ANR7) Thymidylate synthase A (EC 2.1.1.45) (TS A) ... 132 1e-30
142TYSA_BACSU (P42326) Thymidylate synthase A (EC 2.1.1.45) (TS A) ... 131 2e-30
143TYSA_BACAM (O30397) Thymidylate synthase A (EC 2.1.1.45) (TS A) ... 129 7e-30
144TYSA_BACAT (O30394) Thymidylate synthase A (EC 2.1.1.45) (TS A) ... 129 7e-30
145TYSY_BACLD (Q65J44) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 128 2e-29
146TYSA_BACLI (Q59212) Thymidylate synthase A (EC 2.1.1.45) (TS A) ... 128 2e-29
147TYSY_BORPE (Q7VUE3) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 115 1e-25
148TYSY_PSEPK (Q88CN9) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 114 2e-25
149TYSY_PSESM (Q87UL4) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 114 3e-25
150TYSY_BORPA (Q7W1A9) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 113 4e-25
151TYSY_BORBR (Q7WP13) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 113 4e-25
152TYSY_FUSNN (Q8RGP6) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 100 5e-21
153TYSY_IDILO (Q5R064) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 91 4e-18
154TYSY_STAEP (P0C0M4) Thymidylate synthase (EC 2.1.1.45) (TS) (TSa... 88 2e-17
155TYSY_HAEIN (P44420) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 88 2e-17
156TYSY_HAEI8 (Q4QM04) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 88 2e-17
157TYSY_VIBF1 (Q5E7P1) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 87 4e-17
158TYSY_PASMU (P57808) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 86 7e-17
159TYSY_MANSM (Q65VJ8) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 83 6e-16
160TYSY_VIBCH (O66108) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 82 2e-15
161TYSY_PHOPR (Q6LUM1) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 81 2e-15
162TYSY_VIBPA (Q87SA0) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 80 4e-15
163TYSY_VIBVY (Q7MNN6) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 80 7e-15
164TYSY_VIBVU (Q8DER9) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 80 7e-15
165TYSY_HAEDU (Q7VMH2) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 72 1e-12
166TYSY_STRMU (Q8DUI4) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 62 1e-09
167TYSY_STRT1 (Q5M0S7) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 62 1e-09
168TYSY_STRA5 (Q8DZ07) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 62 2e-09
169TYSY_STRA3 (Q8E4L6) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 62 2e-09
170TYSY_STRT2 (Q5M5B3) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 61 2e-09
171TYSY_STRR6 (P67050) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 60 4e-09
172TYSY_STRPN (P67049) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 60 4e-09
173TYSY_STRP3 (P67052) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 58 3e-08
174TYSY_STRP1 (P67051) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 58 3e-08
175TYSY_STRP8 (Q8P1D1) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 56 8e-08
176TYSY_STRP6 (Q5XCM3) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 56 8e-08
177DUHM_BPSP1 (P31654) Deoxyuridylate hydroxymethyltransferase (EC ... 55 2e-07
178TYSY_LACLA (P19368) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 52 2e-06
179TYSY_METMA (Q8PXI1) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 50 4e-06
180TYSY_METAC (Q8THH4) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 50 6e-06
181TYSY_METTH (O26868) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 45 1e-04
182TYSY_METKA (Q8TVL9) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 43 7e-04
183TYSY_METJA (Q57931) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 43 9e-04
184TYSY_METTM (P80305) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) 40 0.004
185MOTB_SALTY (P55892) Chemotaxis protein motB (Motility protein B) 31 3.5
186SYV_XYLFA (Q9PH12) Valyl-tRNA synthetase (EC 6.1.1.9) (Valine--t... 30 4.6
187SYE_BUCAI (P57173) Glutamyl-tRNA synthetase (EC 6.1.1.17) (Gluta... 30 4.6
188FDHD_ERWCT (Q6DB09) Protein fdhD homolog 30 4.6
189INV1_HANAN (P40912) Invertase precursor (EC 3.2.1.26) (Beta-fruc... 30 6.0
190IATR_SHEEP (P62757) Inter-alpha-trypsin inhibitor (ITI) (Inhibit... 30 6.0
191IATR_CAPHI (P62756) Inter-alpha-trypsin inhibitor (ITI) (GIK-14)... 30 6.0
192AMBP_MESAU (Q60559) AMBP protein precursor [Contains: Alpha-1-mi... 30 7.8 
>DRTS_MAIZE (O81395) Bifunctional dihydrofolate reductase-thymidylate synthase|
           (DHFR-TS) [Includes: Dihydrofolate reductase (EC
           1.5.1.3); Thymidylate synthase (EC 2.1.1.45)]
          Length = 521

 Score =  342 bits (877), Expect = 5e-94
 Identities = 162/182 (89%), Positives = 172/182 (94%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GP+Y FQ RHFGAEY+DMHADYTGKGFDQL DVI+KIKN+P+DRRIILSAWNP+DLKKMA
Sbjct: 340 GPIYGFQWRHFGAEYTDMHADYTGKGFDQLMDVIDKIKNDPEDRRIILSAWNPSDLKKMA 399

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLT MIAQVCDLSPG+FVHV
Sbjct: 400 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTYMIAQVCDLSPGDFVHV 459

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKM 94
           IGDAHVY  HV+ALEEQ+QK PKPFPILKINP KKDIDSF+ASDFKL  YDPHQKIEMKM
Sbjct: 460 IGDAHVYRNHVRALEEQIQKMPKPFPILKINPSKKDIDSFMASDFKLVGYDPHQKIEMKM 519

Query: 93  AV 88
           AV
Sbjct: 520 AV 521
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>DRTS2_ARATH (Q05763) Bifunctional dihydrofolate reductase-thymidylate synthase|
           2 (DHFR-TS 2) [Includes: Dihydrofolate reductase (EC
           1.5.1.3); Thymidylate synthase (EC 2.1.1.45)]
          Length = 518

 Score =  325 bits (833), Expect = 7e-89
 Identities = 150/182 (82%), Positives = 166/182 (91%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GPVY FQ RHFGA+Y+DMHADYTG+GFDQL DVINKIKNNPDDRRII+SAWNP+DLK MA
Sbjct: 337 GPVYGFQWRHFGAKYTDMHADYTGQGFDQLLDVINKIKNNPDDRRIIMSAWNPSDLKLMA 396

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           LPPCHMFAQFYV NGELSCQMYQRSADMGLGVPFNIASYSLLTC++A VCDL PG+F+HV
Sbjct: 397 LPPCHMFAQFYVANGELSCQMYQRSADMGLGVPFNIASYSLLTCILAHVCDLVPGDFIHV 456

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKM 94
           IGDAHVY  HV+ L+EQL+  PKPFP+LKINP KKDIDSFVA DF+L  YDPH+KI+MKM
Sbjct: 457 IGDAHVYKNHVRPLQEQLENPPKPFPVLKINPEKKDIDSFVADDFELIGYDPHKKIDMKM 516

Query: 93  AV 88
           AV
Sbjct: 517 AV 518
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>DRTS1_ARATH (Q05762) Bifunctional dihydrofolate reductase-thymidylate synthase|
           1 (DHFR-TS 1) [Includes: Dihydrofolate reductase (EC
           1.5.1.3); Thymidylate synthase (EC 2.1.1.45)]
          Length = 519

 Score =  321 bits (823), Expect = 1e-87
 Identities = 149/182 (81%), Positives = 164/182 (90%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GPVY FQ RHFGA+Y+DMHADYTG+GFDQL DVI+KIKNNPDDRRII+SAWNP+DLK MA
Sbjct: 338 GPVYGFQWRHFGAKYTDMHADYTGQGFDQLVDVIDKIKNNPDDRRIIMSAWNPSDLKLMA 397

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           LPPCHMFAQFYV  GELSCQMYQRSADMGLGVPFNIASYSLLTCM+A VCDL PG+F+HV
Sbjct: 398 LPPCHMFAQFYVAEGELSCQMYQRSADMGLGVPFNIASYSLLTCMLAHVCDLVPGDFIHV 457

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKM 94
           +GDAHVY THV+ L+EQL   PKPFP++KINP KK IDSFVASDF L  YDPH+KIEMKM
Sbjct: 458 LGDAHVYKTHVRPLQEQLLNLPKPFPVMKINPEKKQIDSFVASDFDLTGYDPHKKIEMKM 517

Query: 93  AV 88
           AV
Sbjct: 518 AV 519
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>DRTS_SOYBN (P51820) Bifunctional dihydrofolate reductase-thymidylate synthase|
           (DHFR-TS) [Includes: Dihydrofolate reductase (EC
           1.5.1.3); Thymidylate synthase (EC 2.1.1.45)]
          Length = 530

 Score =  318 bits (816), Expect = 6e-87
 Identities = 147/182 (80%), Positives = 162/182 (89%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GPVY FQ RHFGA Y+DMH DY+G+GFDQL DVINKIK NPDDRRIILSAWNP DLK MA
Sbjct: 349 GPVYGFQWRHFGARYTDMHHDYSGQGFDQLLDVINKIKRNPDDRRIILSAWNPVDLKLMA 408

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           LPPCHMFAQFYV +GELSCQMYQRSADMGLG+PFNIASY+LLTCMIA VCDL PG+F+HV
Sbjct: 409 LPPCHMFAQFYVAHGELSCQMYQRSADMGLGIPFNIASYALLTCMIAHVCDLIPGDFIHV 468

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKM 94
           IGDAH+Y  HV+ L+EQL  QPKPFP LKINP KKDIDSFVA+DFKL  YDPHQKI+MK+
Sbjct: 469 IGDAHIYRNHVRPLQEQLHNQPKPFPTLKINPKKKDIDSFVAADFKLIGYDPHQKIDMKL 528

Query: 93  AV 88
           +V
Sbjct: 529 SV 530
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>DRTS_DAUCA (P45350) Bifunctional dihydrofolate reductase-thymidylate synthase|
           (DHFR-TS) [Includes: Dihydrofolate reductase (EC
           1.5.1.3); Thymidylate synthase (EC 2.1.1.45)]
          Length = 528

 Score =  300 bits (767), Expect = 3e-81
 Identities = 143/183 (78%), Positives = 158/183 (86%), Gaps = 1/183 (0%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GP+Y FQ RHFGA Y+DMHADY+G+GFDQL DVI+KIKNNPDDRRII SAWNP+DL+ MA
Sbjct: 346 GPIYGFQWRHFGARYTDMHADYSGQGFDQLLDVISKIKNNPDDRRIIQSAWNPSDLRLMA 405

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           LPPCHMFAQFYV NGELSCQMYQRSADMGLGVPFNIA+Y+LLTCMIA VCDL PG+FVH 
Sbjct: 406 LPPCHMFAQFYVANGELSCQMYQRSADMGLGVPFNIAAYALLTCMIAHVCDLVPGDFVHS 465

Query: 273 IGDAHVYSTHVQAL-EEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMK 97
           IGDAHVYS H+  L E   +  PK FP+LKIN  +KDIDSF A+DFKL  YDPHQKIEMK
Sbjct: 466 IGDAHVYSNHLSDLFETSFRMLPKTFPVLKINSGEKDIDSFEAADFKLIGYDPHQKIEMK 525

Query: 96  MAV 88
           MAV
Sbjct: 526 MAV 528
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>TYSY_PNECA (P13100) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 297

 Score =  253 bits (646), Expect = 3e-67
 Identities = 114/188 (60%), Positives = 143/188 (76%), Gaps = 6/188 (3%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GP+Y FQ RHFGAEY D   +Y G+G DQLA++I KI+ +P DRR+ILSAWNP DL+KMA
Sbjct: 110 GPIYGFQWRHFGAEYIDCKTNYIGQGVDQLANIIQKIRTSPYDRRLILSAWNPADLEKMA 169

Query: 453 LPPCHMFAQFYVE------NGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSP 292
           LPPCHMF QFYV         ELSCQ+YQRS DMGLGVPFNIASY+LLTCMIA VCDL P
Sbjct: 170 LPPCHMFCQFYVHIPSNNHRPELSCQLYQRSCDMGLGVPFNIASYALLTCMIAHVCDLDP 229

Query: 291 GEFVHVIGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQ 112
           G+F+HV+GD H+Y  H++AL++QL + P+PFP L +N    DI+ F   DF +  Y P++
Sbjct: 230 GDFIHVMGDCHIYKDHIEALQQQLTRSPRPFPTLSLNRSITDIEDFTLDDFNIQNYHPYE 289

Query: 111 KIEMKMAV 88
            I+MKM++
Sbjct: 290 TIKMKMSI 297
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>TYSY_MOUSE (P07607) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 307

 Score =  251 bits (641), Expect = 1e-66
 Identities = 117/182 (64%), Positives = 140/182 (76%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GPVY FQ RHFGAEY DM +DY+G+G DQL  VI+ IK NPDDRRII+ AWNP DL  MA
Sbjct: 126 GPVYGFQWRHFGAEYKDMDSDYSGQGVDQLQKVIDTIKTNPDDRRIIMCAWNPKDLPLMA 185

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           LPPCH   QFYV NGELSCQ+YQRS DMGLGVPFNIASY+LLT MIA +  L PG+FVH 
Sbjct: 186 LPPCHALCQFYVVNGELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLQPGDFVHT 245

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKM 94
           +GDAH+Y  H++ L+ QLQ++P+PFP LKI    + ID F   DF++  Y+PH  I+M+M
Sbjct: 246 LGDAHIYLNHIEPLKIQLQREPRPFPKLKILRKVETIDDFKVEDFQIEGYNPHPTIKMEM 305

Query: 93  AV 88
           AV
Sbjct: 306 AV 307
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>TYSY_RAT (P45352) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 307

 Score =  249 bits (635), Expect = 6e-66
 Identities = 115/182 (63%), Positives = 140/182 (76%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GPVY FQ RHFGA+Y DM +DY+G+G DQL  VI+ IK NPDDRRII+ AWNP DL  MA
Sbjct: 126 GPVYGFQWRHFGADYKDMDSDYSGQGVDQLQKVIDTIKTNPDDRRIIMCAWNPKDLPLMA 185

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           LPPCH   QFYV NGELSCQ+YQRS DMGLGVPFNIASY+LLT MIA +  L PG+FVH 
Sbjct: 186 LPPCHALCQFYVVNGELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLQPGDFVHT 245

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKM 94
           +GDAH+Y  H++ L+ QLQ++P+PFP L+I    + ID F   DF++  Y+PH  I+M+M
Sbjct: 246 LGDAHIYLNHIEPLKIQLQREPRPFPKLRILRKVETIDDFKVEDFQIEGYNPHPTIKMEM 305

Query: 93  AV 88
           AV
Sbjct: 306 AV 307
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>TYSY_HUMAN (P04818) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 312

 Score =  248 bits (634), Expect = 8e-66
 Identities = 115/182 (63%), Positives = 140/182 (76%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GPVY FQ RHFGAEY DM +DY+G+G DQL  VI+ IK NPDDRRII+ AWNP DL  MA
Sbjct: 131 GPVYGFQWRHFGAEYRDMESDYSGQGVDQLQRVIDTIKTNPDDRRIIMCAWNPRDLPLMA 190

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           LPPCH   QFYV N ELSCQ+YQRS DMGLGVPFNIASY+LLT MIA +  L PG+F+H 
Sbjct: 191 LPPCHALCQFYVVNSELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLKPGDFIHT 250

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKM 94
           +GDAH+Y  H++ L+ QLQ++P+PFP L+I    + ID F A DF++  Y+PH  I+M+M
Sbjct: 251 LGDAHIYLNHIEPLKIQLQREPRPFPKLRILRKVEKIDDFKAEDFQIEGYNPHPTIKMEM 310

Query: 93  AV 88
           AV
Sbjct: 311 AV 312
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>DRTS_PLACH (P20712) Bifunctional dihydrofolate reductase-thymidylate synthase|
           (DHFR-TS) [Includes: Dihydrofolate reductase (EC
           1.5.1.3); Thymidylate synthase (EC 2.1.1.45)]
          Length = 583

 Score =  247 bits (631), Expect = 2e-65
 Identities = 116/181 (64%), Positives = 140/181 (77%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GP+Y FQ RHFGAEY+DMHADY  KG DQL ++IN IKN+P  RRIIL AWN  DL +MA
Sbjct: 402 GPIYGFQWRHFGAEYTDMHADYKDKGVDQLKNIINLIKNDPTCRRIILCAWNVKDLDQMA 461

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           LPPCH+  QFYV +G+LSC MYQRS D+GLGVPFNIASYS+ T MIAQVC+L P EF+HV
Sbjct: 462 LPPCHILCQFYVFDGKLSCIMYQRSCDLGLGVPFNIASYSIFTYMIAQVCNLQPAEFIHV 521

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKM 94
           +G+AHVY+ HV++L+ QL + P PFP LK+NP  K+I+ F  SDF +  Y  H KI M M
Sbjct: 522 LGNAHVYNNHVESLKVQLNRTPYPFPTLKLNPEIKNIEDFTISDFTVQNYVHHDKISMDM 581

Query: 93  A 91
           A
Sbjct: 582 A 582
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>DRTS_PARTE (Q27828) Bifunctional dihydrofolate reductase-thymidylate synthase|
           (DHFR-TS) [Includes: Dihydrofolate reductase (EC
           1.5.1.3); Thymidylate synthase (EC 2.1.1.45)]
          Length = 462

 Score =  246 bits (628), Expect = 4e-65
 Identities = 112/182 (61%), Positives = 143/182 (78%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GPVY FQ RHFGA+Y D   DY+ +G DQ+ ++I  +KNNPD RRIILSAWNP DLK+MA
Sbjct: 282 GPVYGFQWRHFGAKYKDCQTDYSNQGVDQVKEIIQLLKNNPDSRRIILSAWNPIDLKQMA 341

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           LPPCH+ +QF+V NG+LSC MYQRS D GLG+PFNIASY+LLT M+A+ C+L+ GEFVHV
Sbjct: 342 LPPCHVMSQFFVANGKLSCMMYQRSCDFGLGIPFNIASYALLTYMLAKECNLNLGEFVHV 401

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKM 94
           +GD H+YS HV+AL++Q+++ P PFP+LKI    K +  +   DF+L  Y+ H KIEMKM
Sbjct: 402 LGDTHIYSNHVEALKKQIERVPYPFPLLKIKG-NKSLFDYTYEDFELVGYNAHDKIEMKM 460

Query: 93  AV 88
           AV
Sbjct: 461 AV 462
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>TYSY_YEAST (P06785) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 304

 Score =  246 bits (627), Expect = 5e-65
 Identities = 118/191 (61%), Positives = 144/191 (75%), Gaps = 9/191 (4%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GPVY FQ RHFGA+Y     DYTG+G DQL  VI+K+K NP DRRII+SAWNP D  KMA
Sbjct: 114 GPVYGFQWRHFGAKYKTCDDDYTGQGIDQLKQVIHKLKTNPYDRRIIMSAWNPADFDKMA 173

Query: 453 LPPCHMFAQFYV---ENGE------LSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCD 301
           LPPCH+F+QFYV   + GE      LSC +YQRS DMGLGVPFNIASY+LLT MIA+V D
Sbjct: 174 LPPCHIFSQFYVSFPKEGEGSGKPRLSCLLYQRSCDMGLGVPFNIASYALLTRMIAKVVD 233

Query: 300 LSPGEFVHVIGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYD 121
           + PGEF+H +GDAHVY  H+ AL+EQ+ + P+PFP LKI    KDID F  +DF++  Y+
Sbjct: 234 MEPGEFIHTLGDAHVYKDHIDALKEQITRNPRPFPKLKIKRDVKDIDDFKLTDFEIEDYN 293

Query: 120 PHQKIEMKMAV 88
           PH +I+MKM+V
Sbjct: 294 PHPRIQMKMSV 304
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>TYSY_DROME (O76511) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 321

 Score =  246 bits (627), Expect = 5e-65
 Identities = 118/184 (64%), Positives = 140/184 (76%), Gaps = 2/184 (1%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GPVY FQ RHFGA+Y     DY+GKG DQL  VI+ I+NNP DRRII+SAWNP D+ KMA
Sbjct: 138 GPVYGFQWRHFGAQYGTCDDDYSGKGIDQLRQVIDTIRNNPSDRRIIMSAWNPLDIPKMA 197

Query: 453 LPPCHMFAQFYV--ENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFV 280
           LPPCH  AQFYV  + GELSCQ+YQRSADMGLGVPFNIASY+LLT MIA V  L PG+FV
Sbjct: 198 LPPCHCLAQFYVSEKRGELSCQLYQRSADMGLGVPFNIASYALLTHMIAHVTGLKPGDFV 257

Query: 279 HVIGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEM 100
           H +GD HVY  HV+ L+EQL++ P+PFP L I    +DI+ F   DF++  Y+PH KI+M
Sbjct: 258 HTMGDTHVYLNHVEPLKEQLERTPRPFPKLIIKRQVQDIEDFRFEDFQIVDYNPHPKIQM 317

Query: 99  KMAV 88
            MAV
Sbjct: 318 DMAV 321
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>TYSY_HHV8 (P90463) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 337

 Score =  246 bits (627), Expect = 5e-65
 Identities = 114/182 (62%), Positives = 136/182 (74%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GPVY FQ RHFGA Y D  ADYTG+GFDQL+ +++ IKNNP DRRII+ AWNP DL  MA
Sbjct: 156 GPVYGFQWRHFGAAYVDADADYTGQGFDQLSYIVDLIKNNPHDRRIIMCAWNPADLSLMA 215

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           LPPCH+  QFYV +GELSCQ+YQRS DMGLGVPFNIASYSLLT M+A V  L PGEF+H 
Sbjct: 216 LPPCHLLCQFYVADGELSCQLYQRSGDMGLGVPFNIASYSLLTYMLAHVTGLRPGEFIHT 275

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKM 94
           +GDAH+Y TH++ L  QL + P+PFP L+I      ++ F   DF+L  Y PH  I M+M
Sbjct: 276 LGDAHIYKTHIEPLRLQLTRTPRPFPRLEILRSVSSMEEFTPDDFRLVDYCPHPTIRMEM 335

Query: 93  AV 88
           AV
Sbjct: 336 AV 337
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>TYSY_EHV2 (Q89940) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 289

 Score =  243 bits (620), Expect = 3e-64
 Identities = 114/182 (62%), Positives = 135/182 (74%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GPVY FQ RHFGA Y D   DY G+G DQL D+I +IK NP+ RR++L+AWNP DL  MA
Sbjct: 108 GPVYGFQWRHFGAAYVDSKTDYRGQGVDQLRDLIGEIKRNPESRRLVLTAWNPADLPAMA 167

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           LPPCH+  QFYV  GELSCQ+YQRS DMGLGVPFNIASYSLLT M+A +  L PG+F+HV
Sbjct: 168 LPPCHLLCQFYVAGGELSCQLYQRSGDMGLGVPFNIASYSLLTYMVAHLTGLEPGDFIHV 227

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKM 94
           +GDAHVY  HV+ L+ QL + P+PFP L+I    +DID F A DF L  Y PH  I M+M
Sbjct: 228 LGDAHVYLNHVEPLKLQLTRSPRPFPRLRILRRVEDIDDFRAEDFALEGYHPHAAIPMEM 287

Query: 93  AV 88
           AV
Sbjct: 288 AV 289
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>TYSY_HSVAT (P12462) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 290

 Score =  239 bits (610), Expect = 5e-63
 Identities = 114/182 (62%), Positives = 135/182 (74%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GPVY FQ RHFGAEY  +  +Y G+G DQL  +IN I  NP DRR+++ AWN  D+ KMA
Sbjct: 109 GPVYGFQWRHFGAEYQGLKHNYGGEGVDQLKQIINTIHTNPTDRRMLMCAWNVLDVPKMA 168

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           LPPCH+ +QFYV +G+LSCQ+YQRSADMGLGVPFNIASYSLLTCMIA V DL PGEF+H 
Sbjct: 169 LPPCHVLSQFYVCDGKLSCQLYQRSADMGLGVPFNIASYSLLTCMIAHVTDLVPGEFIHT 228

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKM 94
           +GDAHVY  HV AL EQL + P+PFP LK       ID F A+D  L  Y+P+  I+M M
Sbjct: 229 LGDAHVYVNHVDALTEQLTRTPRPFPTLKFARKVASIDDFKANDIILENYNPYPSIKMPM 288

Query: 93  AV 88
           AV
Sbjct: 289 AV 290
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>DRTS_TOXGO (Q07422) Bifunctional dihydrofolate reductase-thymidylate synthase|
           (DHFR-TS) [Includes: Dihydrofolate reductase (EC
           1.5.1.3); Thymidylate synthase (EC 2.1.1.45)]
          Length = 610

 Score =  238 bits (608), Expect = 8e-63
 Identities = 111/185 (60%), Positives = 142/185 (76%), Gaps = 3/185 (1%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GP Y FQ RHFGA Y DMH DYTG+G DQL +VI  ++ NP DRR++++AWNP  L +MA
Sbjct: 426 GPGYGFQWRHFGAAYKDMHTDYTGQGVDQLKNVIQMLRTNPTDRRMLMTAWNPAALDEMA 485

Query: 453 LPPCHMFAQFYV-ENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVH 277
           LPPCH+  QFYV +  ELSC MYQRS D+GLGVPFNIASYSLLT M+A VC+L P EF+H
Sbjct: 486 LPPCHLLCQFYVNDQKELSCIMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKPKEFIH 545

Query: 276 VIGDAHVYSTHVQALEEQLQKQPKPFPILKI--NPLKKDIDSFVASDFKLACYDPHQKIE 103
            +G+ HVY+ HV+AL+EQL+++P+PFPI+ I      K+ID F A DF++  Y PH +I+
Sbjct: 546 FMGNTHVYTNHVEALKEQLRREPRPFPIVNILNKERIKEIDDFTAEDFEVVGYVPHGRIQ 605

Query: 102 MKMAV 88
           M+MAV
Sbjct: 606 MEMAV 610
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>DRTS_PLAVI (O02604) Bifunctional dihydrofolate reductase-thymidylate synthase|
           (DHFR-TS) [Includes: Dihydrofolate reductase (EC
           1.5.1.3); Thymidylate synthase (EC 2.1.1.45)]
          Length = 623

 Score =  238 bits (607), Expect = 1e-62
 Identities = 111/181 (61%), Positives = 138/181 (76%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GP+Y FQ RHFGAEY++MH +Y  KG DQL +VI+ IKN P  RRIIL AWN  DL +MA
Sbjct: 442 GPIYGFQWRHFGAEYTNMHDNYEDKGVDQLKNVIHLIKNEPTSRRIILCAWNVKDLDQMA 501

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           LPPCH+  QFYV +G+LSC MYQRS D+GLGVPFNIASYS+ T MIAQVC+L P +F+H+
Sbjct: 502 LPPCHILCQFYVFDGKLSCIMYQRSCDLGLGVPFNIASYSIFTHMIAQVCNLQPAQFIHI 561

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKM 94
           +G+AHVY+ HV +L+ QL + P PFP LK+NP  K+I+ F  SDF +  Y  H KI M+M
Sbjct: 562 LGNAHVYNNHVDSLKVQLNRIPYPFPTLKLNPEVKNIEDFTISDFTIENYVHHDKITMEM 621

Query: 93  A 91
           A
Sbjct: 622 A 622
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>DRTS_PLABA (Q27713) Bifunctional dihydrofolate reductase-thymidylate synthase|
           (DHFR-TS) [Includes: Dihydrofolate reductase (EC
           1.5.1.3); Thymidylate synthase (EC 2.1.1.45)]
          Length = 587

 Score =  237 bits (604), Expect = 2e-62
 Identities = 111/181 (61%), Positives = 138/181 (76%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GP+Y FQ RHFGAEY+DMH +Y  KG DQL ++IN IKN+P  RRIIL AWN  +L +MA
Sbjct: 406 GPIYGFQWRHFGAEYTDMHDNYKDKGVDQLKNIINLIKNDPTCRRIILCAWNVKNLDQMA 465

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           LPPCH+  QFYV +G+LSC MYQRS D+GLGVPFNIASYS+ T MIAQVC+L   EF+HV
Sbjct: 466 LPPCHILCQFYVFDGKLSCIMYQRSCDLGLGVPFNIASYSIFTYMIAQVCNLQAAEFIHV 525

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKM 94
           +G+AHVY+ H+++L+ QL + P PFP LK+NP  K+I+ F  SDF +  Y  H KI M M
Sbjct: 526 LGNAHVYNNHIESLKIQLNRTPYPFPTLKLNPDIKNIEDFTISDFTVQNYVHHDKINMDM 585

Query: 93  A 91
           A
Sbjct: 586 A 586
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>DRTS_PLAFK (P13922) Bifunctional dihydrofolate reductase-thymidylate synthase|
           (DHFR-TS) [Includes: Dihydrofolate reductase (EC
           1.5.1.3); Thymidylate synthase (EC 2.1.1.45)]
          Length = 608

 Score =  236 bits (603), Expect = 3e-62
 Identities = 109/181 (60%), Positives = 139/181 (76%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GP+Y FQ RHFGAEY++M+ +Y  KG DQL ++IN IKN+P  RRI+L AWN  DL +MA
Sbjct: 427 GPIYGFQWRHFGAEYTNMYDNYENKGVDQLKNIINLIKNDPTSRRILLCAWNVKDLDQMA 486

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           LPPCH+  QFYV +G+LSC MYQRS D+GLGVPFNIASYS+ T MIAQVC+L P +F+HV
Sbjct: 487 LPPCHILCQFYVFDGKLSCIMYQRSCDLGLGVPFNIASYSIFTHMIAQVCNLQPAQFIHV 546

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKM 94
           +G+AHVY+ H+ +L+ QL + P PFP LK+NP  K+I+ F  SDF +  Y  H+KI M M
Sbjct: 547 LGNAHVYNNHIDSLKIQLNRIPYPFPTLKLNPDIKNIEDFTISDFTIQNYVHHEKISMDM 606

Query: 93  A 91
           A
Sbjct: 607 A 607
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>TYSY_SHV21 (P06854) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 294

 Score =  234 bits (598), Expect = 1e-61
 Identities = 111/182 (60%), Positives = 135/182 (74%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GPVY FQ RHFGAEY  +  DY G+G DQL  +I+ IK NP DRR+++ AWN +D+ KM 
Sbjct: 113 GPVYGFQWRHFGAEYKGVGRDYKGEGVDQLKQLIDTIKTNPTDRRMLMCAWNVSDIPKMV 172

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           LPPCH+ +QFYV +G+LSCQ+YQRSADMGLGVPFNIASYSLLTCMIA V +L PGEF+H 
Sbjct: 173 LPPCHVLSQFYVCDGKLSCQLYQRSADMGLGVPFNIASYSLLTCMIAHVTNLVPGEFIHT 232

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKM 94
           IGDAH+Y  H+ AL+ QL + P+PFP L+       ID F A D  L  Y+PH  I+M M
Sbjct: 233 IGDAHIYVDHIDALKMQLTRTPRPFPTLRFARNVSCIDDFKADDIILENYNPHPIIKMHM 292

Query: 93  AV 88
           AV
Sbjct: 293 AV 294
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>TYSY_CANAL (P12461) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 314

 Score =  231 bits (589), Expect = 1e-60
 Identities = 116/203 (57%), Positives = 139/203 (68%), Gaps = 21/203 (10%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GPVY FQ RHFGAEY D  +DYTG+GFDQL DVI K+K NP DRRII+SAWNP D  KMA
Sbjct: 112 GPVYGFQWRHFGAEYKDCDSDYTGQGFDQLQDVIKKLKTNPYDRRIIMSAWNPPDFAKMA 171

Query: 453 LPPCHMFAQFYVE-----------------NGELSCQMYQRSADMGLGVPFNIASYSLLT 325
           LPPCH+F QFYV                    +LSC +YQRS DMGLGVPFNIASY+LLT
Sbjct: 172 LPPCHVFCQFYVNFPTSSPDPNNPKQAKTAKPKLSCLLYQRSCDMGLGVPFNIASYALLT 231

Query: 324 CMIAQVCDLSPGEFVHVIGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKD----IDS 157
            MIA V D+  GEF+H +GDAHVY  H+ AL+EQ ++ PK FP L I   +K+    ID 
Sbjct: 232 KMIAHVVDMDCGEFIHTLGDAHVYLDHIDALKEQFERIPKQFPKLVIKEERKNEIKSIDD 291

Query: 156 FVASDFKLACYDPHQKIEMKMAV 88
           F   DF++  Y+P+  I+MKM+V
Sbjct: 292 FKFEDFEIVGYEPYPPIKMKMSV 314
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>TYSY_ASCSU (O96650) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 294

 Score =  231 bits (589), Expect = 1e-60
 Identities = 113/182 (62%), Positives = 130/182 (71%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GP+Y FQ RHFGAEY    ADY G+G DQLADVI +IKNNP+ RRIIL+AWN  DL +MA
Sbjct: 113 GPIYGFQWRHFGAEYHGTDADYKGQGVDQLADVIEQIKNNPNSRRIILNAWNVKDLHQMA 172

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           LPPCH  AQF V+NGELSCQ+YQRS DMGLGVPFN+ASY LLT MIA VC L  G   HV
Sbjct: 173 LPPCHTLAQFAVKNGELSCQLYQRSGDMGLGVPFNLASYGLLTHMIAHVCALKTGFLHHV 232

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKM 94
           +GDAHVY  H+ AL+EQL + P+PFP +        ID F A    L  Y+P   I+M M
Sbjct: 233 LGDAHVYLNHIDALKEQLSRDPRPFPTVHFEGRIDSIDDFTAESIILNGYNPMAPIKMPM 292

Query: 93  AV 88
           AV
Sbjct: 293 AV 294
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>TYSY_VZVD (P09249) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 301

 Score =  225 bits (573), Expect = 1e-58
 Identities = 103/182 (56%), Positives = 131/182 (71%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GP+Y FQ RHFGAEY D  ++Y  +G DQL  VI+ IK NP+ RR+I+S+WNP D+  M 
Sbjct: 120 GPIYGFQWRHFGAEYKDCQSNYLQQGIDQLQTVIDTIKTNPESRRMIISSWNPKDIPLMV 179

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           LPPCH   QFYV NGELSCQ+YQRS DMGLGVPFNIA Y+LLT ++A V  L  G+ +H 
Sbjct: 180 LPPCHTLCQFYVANGELSCQVYQRSGDMGLGVPFNIAGYALLTYIVAHVTGLKTGDLIHT 239

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKM 94
           +GDAH+Y  H+ AL+ QL + PKPFP LKI     DI+ F   DF+L  Y+PH  ++M+M
Sbjct: 240 MGDAHIYLNHIDALKVQLARSPKPFPCLKIIRNVTDINDFKWDDFQLDGYNPHPPLKMEM 299

Query: 93  AV 88
           A+
Sbjct: 300 AL 301
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>DRTS_TRYBB (Q27783) Bifunctional dihydrofolate reductase-thymidylate synthase|
           (DHFR-TS) [Includes: Dihydrofolate reductase (EC
           1.5.1.3); Thymidylate synthase (EC 2.1.1.45)]
          Length = 527

 Score =  225 bits (573), Expect = 1e-58
 Identities = 103/182 (56%), Positives = 131/182 (71%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GPVY FQ RHFGA+Y     D  GKG DQ+A+++  +  NPDDRR+I +AWNP  L +MA
Sbjct: 346 GPVYGFQWRHFGADYISCKVDSEGKGVDQIANIVKSLIENPDDRRMICTAWNPAALPRMA 405

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           LPPCHM AQFYV NGELSC +YQRS DMGLGVPFNIASY+LLT ++A+   L PGE VH 
Sbjct: 406 LPPCHMMAQFYVSNGELSCMLYQRSCDMGLGVPFNIASYALLTFLMAKASGLRPGELVHT 465

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKM 94
           +GDAHVYS HV+   +QL++ P+PFP +     K+ ++ F  SD ++  Y P+  I M+M
Sbjct: 466 LGDAHVYSNHVEPCRKQLKRVPRPFPFIVFKQDKEFLEDFQESDIEVIDYSPYPVISMEM 525

Query: 93  AV 88
           AV
Sbjct: 526 AV 527
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>TYSY_AGABI (Q9P4T7) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 296

 Score =  223 bits (569), Expect = 3e-58
 Identities = 114/189 (60%), Positives = 132/189 (69%), Gaps = 7/189 (3%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GPVY FQ RHFGAEY D  ADY GKG DQL + I KIK NP DRRIILSAWNP D+  MA
Sbjct: 108 GPVYGFQWRHFGAEYEDCDADYAGKGVDQLRECIRKIKENPTDRRIILSAWNPKDIPSMA 167

Query: 453 LPPCHMFAQFYVE------NGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSP 292
           LPPCHM  QFYV         ELSC M+QRSAD+GLG+PFNIASY+LLT MIA V   + 
Sbjct: 168 LPPCHMLCQFYVHLPADTAKPELSCLMFQRSADLGLGIPFNIASYALLTHMIAHVTGTTA 227

Query: 291 GEFVHVIGDAHVYSTHVQALEEQLQKQPKPFPILK-INPLKKDIDSFVASDFKLACYDPH 115
            E +  +GDAHVY  HV+ALE QLQ++P+PFP L+       DI+ F  SDF +  Y+PH
Sbjct: 228 RELIIQLGDAHVYRDHVEALEVQLQREPRPFPKLRWARDGITDIEDFEYSDFVIEGYNPH 287

Query: 114 QKIEMKMAV 88
             I MKM+V
Sbjct: 288 PSIAMKMSV 296
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>DRTS_TRYCR (Q27793) Bifunctional dihydrofolate reductase-thymidylate synthase|
           (DHFR-TS) [Includes: Dihydrofolate reductase (EC
           1.5.1.3); Thymidylate synthase (EC 2.1.1.45)]
          Length = 521

 Score =  222 bits (565), Expect = 8e-58
 Identities = 101/182 (55%), Positives = 131/182 (71%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GPVY FQ RHFGA Y+   A+Y G+G DQ+  ++  +K NPDDRR++ +AWNP+ L +MA
Sbjct: 340 GPVYGFQWRHFGAAYTHHDANYDGQGVDQIKAIVETLKTNPDDRRMLFTAWNPSALPRMA 399

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           LPPCH+ AQFYV NGELSC +YQRS DMGLGVPFNIASY+LLT +IA+   L PGE VH 
Sbjct: 400 LPPCHLLAQFYVSNGELSCMLYQRSCDMGLGVPFNIASYALLTILIAKATGLRPGELVHT 459

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKM 94
           +GDAHVYS HV+   EQL++ P+ FP L     ++ ++ +   D ++  Y P+  I MKM
Sbjct: 460 LGDAHVYSNHVEPCNEQLKRVPRAFPYLVFRREREFLEDYEEGDMEVIDYAPYPPISMKM 519

Query: 93  AV 88
           AV
Sbjct: 520 AV 521
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>TYSY_CRYNE (P45351) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 317

 Score =  220 bits (560), Expect = 3e-57
 Identities = 114/193 (59%), Positives = 133/193 (68%), Gaps = 12/193 (6%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GPVY FQ RHFGAEY+D   DY GKG DQL  VI+ IKNNP DRRIILSAWNP DL  MA
Sbjct: 124 GPVYGFQWRHFGAEYTDADGDYKGKGVDQLQRVIDTIKNNPTDRRIILSAWNPKDLPLMA 183

Query: 453 LPPCHMFAQFYV---------ENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCD 301
           LPPCHMF QF+V            +LSC MYQRS D+GLGVPFNIASY+LLT MIA + D
Sbjct: 184 LPPCHMFCQFFVSLPPADSPGSKPKLSCLMYQRSCDLGLGVPFNIASYALLTHMIALITD 243

Query: 300 LSPGEFVHVIGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKK---DIDSFVASDFKLA 130
             P EF+  +GDAHVY  HV+ L+ QL+++P+ FP LK    K+   DID F   DF + 
Sbjct: 244 TEPHEFILQMGDAHVYRDHVEPLKTQLEREPRDFPKLKWARSKEEIGDIDGFKVEDFVVE 303

Query: 129 CYDPHQKIEMKMA 91
            Y P  KI+MKM+
Sbjct: 304 GYKPWGKIDMKMS 316
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>TYS1_ENCCU (O62584) Thymidylate synthase 1/2 (EC 2.1.1.45) (TS 1/2) (TSase|
           1/2)
          Length = 294

 Score =  219 bits (559), Expect = 4e-57
 Identities = 104/183 (56%), Positives = 130/183 (71%), Gaps = 2/183 (1%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GP+Y FQ RHFGA Y    + Y GKG DQ+A  I  I+ NP  RRI++SAWNPTDL  MA
Sbjct: 111 GPIYGFQWRHFGARYETSASSYEGKGVDQIASAIAAIRANPASRRIVVSAWNPTDLGSMA 170

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           LPPCH+  QF V +G+LSC MYQRS DMGLGVPFNIASYSLLT ++A +  L PGEFVH 
Sbjct: 171 LPPCHVLFQFNVTDGKLSCAMYQRSGDMGLGVPFNIASYSLLTILVAHLTGLQPGEFVHF 230

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPL--KKDIDSFVASDFKLACYDPHQKIEM 100
           +GDAHVY  HV +L +Q+Q+ P+ FP L ++P   + + + F   DF+L  YDPH  I+M
Sbjct: 231 LGDAHVYLDHVDSLRQQIQRPPRAFPKLFVSPKGPRTEPEHFQYEDFELVGYDPHPAIKM 290

Query: 99  KMA 91
            M+
Sbjct: 291 NMS 293
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>TYS3_ENCCU (Q8SRG2) Thymidylate synthase 3 (EC 2.1.1.45) (TS 3) (TSase 3)|
          Length = 294

 Score =  219 bits (558), Expect = 5e-57
 Identities = 104/183 (56%), Positives = 130/183 (71%), Gaps = 2/183 (1%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GP+Y FQ RHFGA Y    + Y GKG DQ+A  I  I+ NP  RRI++SAWNPTDL  MA
Sbjct: 111 GPIYGFQWRHFGARYETSASSYEGKGVDQIASAIAAIRANPASRRIVVSAWNPTDLGSMA 170

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           LPPCH+  QF V +G+LSC MYQRS DMGLGVPFNIASYSLLT ++A +  L PGEFVH 
Sbjct: 171 LPPCHVLFQFNVTDGKLSCAMYQRSGDMGLGVPFNIASYSLLTILVAHLTGLQPGEFVHF 230

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPL--KKDIDSFVASDFKLACYDPHQKIEM 100
           +GDAHVY  HV +L +Q+Q+ P+ FP L ++P   + + + F   DF+L  YDPH  I+M
Sbjct: 231 LGDAHVYLDHVDSLRQQVQRPPRAFPKLFVSPKGPRTEPEHFQYEDFELVGYDPHPAIKM 290

Query: 99  KMA 91
            M+
Sbjct: 291 NMS 293
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>DRTS_LEIAM (P16126) Bifunctional dihydrofolate reductase-thymidylate synthase|
           (DHFR-TS) [Includes: Dihydrofolate reductase (EC
           1.5.1.3); Thymidylate synthase (EC 2.1.1.45)]
          Length = 520

 Score =  215 bits (548), Expect = 8e-56
 Identities = 101/184 (54%), Positives = 131/184 (71%), Gaps = 2/184 (1%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GPVY FQ RHFGAEY  + A+Y G+G DQ+  ++  IK NP+DRR++ +AWNP  L KMA
Sbjct: 337 GPVYGFQWRHFGAEYRGLEANYDGEGVDQIKFIVETIKANPNDRRLLFTAWNPCALHKMA 396

Query: 453 LPPCHMFAQFYV--ENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFV 280
           LPPCH+ AQFYV  E  ELSC +YQRS DMGLGVPFNIASY+LLT +IA+   L PGE V
Sbjct: 397 LPPCHLLAQFYVNTEKSELSCMLYQRSCDMGLGVPFNIASYALLTILIAKATGLRPGELV 456

Query: 279 HVIGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEM 100
           H +GDAHVY +H+ AL+ QL++ P  FP L     ++ ++ +   D ++  Y PH  I+M
Sbjct: 457 HTLGDAHVYRSHIDALKAQLERVPHAFPTLVFKEERQFLEDYELMDMEVIDYVPHPPIKM 516

Query: 99  KMAV 88
           +MAV
Sbjct: 517 EMAV 520
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>DRTS_LEIMA (P07382) Bifunctional dihydrofolate reductase-thymidylate synthase|
           (DHFR-TS) [Includes: Dihydrofolate reductase (EC
           1.5.1.3); Thymidylate synthase (EC 2.1.1.45)]
          Length = 520

 Score =  214 bits (546), Expect = 1e-55
 Identities = 100/184 (54%), Positives = 132/184 (71%), Gaps = 2/184 (1%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GPVY FQ RHFGA+Y    A+Y G+G DQ+  ++  IK NP+DRR++++AWNP  L+KMA
Sbjct: 337 GPVYGFQWRHFGADYKGFEANYDGEGVDQIKLIVETIKTNPNDRRLLVTAWNPCALQKMA 396

Query: 453 LPPCHMFAQFYV--ENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFV 280
           LPPCH+ AQFYV  +  ELSC +YQRS DMGLGVPFNIASY+LLT +IA+   L PGE V
Sbjct: 397 LPPCHLLAQFYVNTDTSELSCMLYQRSCDMGLGVPFNIASYALLTILIAKATGLRPGELV 456

Query: 279 HVIGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEM 100
           H +GDAHVY  HV AL+ QL++ P  FP L     ++ ++ +  +D ++  Y PH  I+M
Sbjct: 457 HTLGDAHVYRNHVDALKAQLERVPHAFPTLIFKEERQYLEDYELTDMEVIDYVPHPAIKM 516

Query: 99  KMAV 88
           +MAV
Sbjct: 517 EMAV 520
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>TYSY_CHRVO (Q7NZ95) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 264

 Score =  208 bits (529), Expect = 1e-53
 Identities = 98/182 (53%), Positives = 128/182 (70%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GPVY +Q R + A          G+  DQ++ +++ IK NPD RR+I+SAWNP  + +MA
Sbjct: 91  GPVYGYQWRSWPAP--------DGRHIDQISQLLDMIKKNPDSRRLIVSAWNPALVDQMA 142

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           LPPCH   QFYV NG LSCQ+YQRSAD+ LGVPFNIASY+LLT M+AQVC L PG+FVH 
Sbjct: 143 LPPCHSLFQFYVANGRLSCQLYQRSADIFLGVPFNIASYALLTMMVAQVCGLQPGDFVHT 202

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKM 94
           +GDAH+YS H++    QL + P+P P +K+NP  KD+ +F   DF L  YDPH  I+ ++
Sbjct: 203 LGDAHLYSNHLEQARLQLTRDPRPLPTMKLNPEVKDLFAFTFDDFALEGYDPHPHIKAQV 262

Query: 93  AV 88
           AV
Sbjct: 263 AV 264
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>TYSY_BRAJA (Q89G35) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 264

 Score =  207 bits (527), Expect = 2e-53
 Identities = 100/182 (54%), Positives = 129/182 (70%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GPVY  Q R + A          G+  DQ+A+V++ IK NPD RR+I+SAWNP ++ KMA
Sbjct: 91  GPVYGHQWRSWPAP--------DGRSIDQIANVVDMIKRNPDSRRLIVSAWNPAEVDKMA 142

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           LPPCH   QFYV NG+LSCQ+YQRSAD+ LGVPFNIASY+LLT M+AQV  L PG+FVH 
Sbjct: 143 LPPCHCLFQFYVANGKLSCQLYQRSADVFLGVPFNIASYALLTMMVAQVTGLKPGDFVHS 202

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKM 94
            GD H+YS H++  + QL + P+  P+++INP  KDI SF   DF+L  YDPH  I+ ++
Sbjct: 203 FGDTHLYSNHLEQAKLQLTRAPRALPVMRINPDVKDIFSFRFEDFELVGYDPHPHIKAEV 262

Query: 93  AV 88
           AV
Sbjct: 263 AV 264
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>TYSY_RHOPA (Q6N447) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 264

 Score =  205 bits (522), Expect = 8e-53
 Identities = 101/182 (55%), Positives = 127/182 (69%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GPVY  Q R +        AD  G   DQ+A+V+  IK NPD RR++++AWNP D++KMA
Sbjct: 91  GPVYGAQWRSWPT------AD--GGSIDQIANVVEMIKRNPDSRRLMVTAWNPADVEKMA 142

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           LPPCH   QFYV NG+LSCQ+YQRSAD+ LGVPFNIASY+LLT M+AQV  L PGEFVH 
Sbjct: 143 LPPCHCLFQFYVANGKLSCQLYQRSADVFLGVPFNIASYALLTLMVAQVTGLKPGEFVHT 202

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKM 94
           +GDAH+YS H++    QL + P+  P++ INP  KDI  F   DF L  YDPH  I+ ++
Sbjct: 203 LGDAHLYSNHLEQARLQLTRAPRALPVMTINPAVKDIFGFRYEDFTLTGYDPHPHIKAEV 262

Query: 93  AV 88
           AV
Sbjct: 263 AV 264
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>TYSY_NEIMB (Q9JY72) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 264

 Score =  204 bits (519), Expect = 2e-52
 Identities = 98/182 (53%), Positives = 129/182 (70%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GPVY +Q R++ A          G+  DQ+A+V+ +IK NPD RR+I+SAWNP  + +MA
Sbjct: 91  GPVYGYQWRNWPAP--------DGRHIDQIANVLEQIKKNPDSRRLIVSAWNPALVDEMA 142

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           LPPCH   QFYV +G+LSCQ+YQRSAD+ LGVPFNIASY+LLT M+AQVC L  GEFVH 
Sbjct: 143 LPPCHALFQFYVADGKLSCQLYQRSADIFLGVPFNIASYALLTMMMAQVCGLEAGEFVHT 202

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKM 94
            GDAH+Y  H +    QL+++P+  P++KINP  KD+ SF   DF+L  YDPH  I+  +
Sbjct: 203 FGDAHLYRNHFEQAALQLEREPRALPVMKINPEVKDLFSFKFEDFELEGYDPHPHIKAAV 262

Query: 93  AV 88
           +V
Sbjct: 263 SV 264
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>TYSY_NEIMA (Q9JT57) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 264

 Score =  203 bits (516), Expect = 4e-52
 Identities = 97/182 (53%), Positives = 129/182 (70%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GPVY +Q R++ A          G+  DQ+A+V+ +IK NPD RR+I+SAWNP  + +MA
Sbjct: 91  GPVYGYQWRNWPAP--------DGRHIDQIANVLEQIKKNPDSRRLIVSAWNPALVDEMA 142

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           LPPCH   QFYV +G+LSCQ+YQRSAD+ LGVPFNIASY+LLT M+AQVC L  GEFVH 
Sbjct: 143 LPPCHALFQFYVADGKLSCQLYQRSADIFLGVPFNIASYALLTMMMAQVCGLEAGEFVHT 202

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKM 94
            GDAH+Y  H +    QL+++P+  P++KINP  KD+ +F   DF+L  YDPH  I+  +
Sbjct: 203 FGDAHLYRNHFEQAALQLEREPRALPVMKINPEVKDLFAFKFEDFELEGYDPHPHIKAAV 262

Query: 93  AV 88
           +V
Sbjct: 263 SV 264
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>TYSY_NEIGO (O33380) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 265

 Score =  202 bits (513), Expect = 9e-52
 Identities = 97/182 (53%), Positives = 127/182 (69%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GPVY +Q R + A          G+  DQ+A+V+ +IK NPD RR+I+SAWNP  + +MA
Sbjct: 92  GPVYGYQWRSWPAP--------DGRHIDQIANVVEQIKKNPDSRRLIVSAWNPALVDEMA 143

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           LPPCH   QFYV +G LSCQ+YQRSAD+ LGVPFNIASY+LLT M+AQVC L  GEFVH 
Sbjct: 144 LPPCHALFQFYVADGNLSCQLYQRSADIFLGVPFNIASYALLTMMMAQVCGLEAGEFVHT 203

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKM 94
            GDAH+Y  H +    QL+++P+  P++KINP  KD+ +F   DF+L  YDPH  I+  +
Sbjct: 204 FGDAHLYRNHFEQAALQLEREPRALPVMKINPEVKDLFAFKFEDFELEGYDPHPHIKAVV 263

Query: 93  AV 88
           +V
Sbjct: 264 SV 265
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>TYSY_METFL (Q9RAM7) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 264

 Score =  199 bits (507), Expect = 4e-51
 Identities = 96/182 (52%), Positives = 127/182 (69%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GPVY +Q R++            G   DQ+++VI  IK+NPD RR+I+SAWN  D+ KM 
Sbjct: 91  GPVYGYQWRNWPKP--------DGGHIDQISEVIAAIKSNPDSRRLIVSAWNVADVDKME 142

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           LPPCH   QFYV  G+LSCQ+YQRSAD+ LGVPFNIASY+LLT M+A+VCDL  G+FVH 
Sbjct: 143 LPPCHALFQFYVAEGKLSCQLYQRSADIFLGVPFNIASYALLTMMVARVCDLELGDFVHT 202

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKM 94
           +GDAH+Y  H++ ++EQL ++P P P+++INP  KDI +F   DF L  Y  H  I+  +
Sbjct: 203 LGDAHIYLNHLEQVKEQLSREPYPLPVMRINPEVKDIFAFRFEDFTLENYQSHPAIKAPV 262

Query: 93  AV 88
           AV
Sbjct: 263 AV 264
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>TYSY_BDEBA (Q6MID2) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 264

 Score =  199 bits (506), Expect = 6e-51
 Identities = 98/182 (53%), Positives = 130/182 (71%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GPVY  Q R +  E +D      G+  DQ+ +V+ +IK NP+ RR+++ A+NP D+ KMA
Sbjct: 91  GPVYGKQWRSW--ETAD------GRTIDQITNVVEQIKKNPNSRRMLVVAFNPGDVDKMA 142

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           LPPCH F QFYV NG+LSCQ+YQRSAD+ LGVPFNIASY+LLT MIAQVCDL  G+FVH 
Sbjct: 143 LPPCHAFFQFYVANGKLSCQLYQRSADIFLGVPFNIASYALLTHMIAQVCDLEVGDFVHT 202

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKM 94
           +GDAH+Y  H++    QL ++ +P P LK+NP KKD+  F   D ++  YDPH  I+ ++
Sbjct: 203 LGDAHLYLNHLEQANLQLTREFRPLPQLKLNPAKKDLFDFTYEDIEIIGYDPHPAIKAEV 262

Query: 93  AV 88
           AV
Sbjct: 263 AV 264
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>TYSY_BACHD (Q9K7B5) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 264

 Score =  195 bits (495), Expect = 1e-49
 Identities = 92/182 (50%), Positives = 126/182 (69%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GPVY  Q R +            GK  DQ++ V+  IK+ PD RR+I+SAWN  +++ MA
Sbjct: 91  GPVYGKQWRSWEGA--------NGKTVDQISQVVEAIKHQPDSRRLIVSAWNAAEIEDMA 142

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           L PCH   QFYV++G+LSCQ+YQRSAD+ LGVPFNIASY+LLT MIAQVCDL  GEFVH 
Sbjct: 143 LAPCHCLFQFYVQDGKLSCQLYQRSADIFLGVPFNIASYALLTKMIAQVCDLEEGEFVHT 202

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKM 94
            GDAH+Y  H++ ++ QL ++P+P P +++NP  + +  F   DF+L  YDPH  I+ ++
Sbjct: 203 FGDAHIYLNHIEQVKLQLTREPRPLPEMRLNPEVRSLFDFTFDDFELVGYDPHPHIKGEV 262

Query: 93  AV 88
           +V
Sbjct: 263 SV 264
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>TYSY_BACHK (Q6HJC7) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 318

 Score =  194 bits (492), Expect = 2e-49
 Identities = 90/159 (56%), Positives = 113/159 (71%)
 Frame = -2

Query: 564 GKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMALPPCHMFAQFYVENGELSCQMYQ 385
           G+  DQL DVI  IK  PD RR+I+SAWNP D+  MALPPCH   QFYV +G+LSCQ+YQ
Sbjct: 160 GETLDQLKDVIEMIKKTPDSRRLIVSAWNPEDVPSMALPPCHTLFQFYVADGKLSCQLYQ 219

Query: 384 RSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHVIGDAHVYSTHVQALEEQLQKQPK 205
           RS D+ LG+PFNIASYSLLT +IA  C L  GEFVH IGDAH+Y+ H + +E+QL ++P+
Sbjct: 220 RSGDIFLGIPFNIASYSLLTHLIAHECGLEVGEFVHTIGDAHIYTNHFEQVEKQLAREPR 279

Query: 204 PFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKMAV 88
           PFP L +NP  K +  F   D  +  YDPH  I+  +AV
Sbjct: 280 PFPKLTLNPDVKSVFDFEMEDLTIEGYDPHPAIKAPVAV 318
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>TYSY_BACCZ (Q63BV5) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 318

 Score =  194 bits (492), Expect = 2e-49
 Identities = 90/159 (56%), Positives = 113/159 (71%)
 Frame = -2

Query: 564 GKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMALPPCHMFAQFYVENGELSCQMYQ 385
           G+  DQL DVI  IK  PD RR+I+SAWNP D+  MALPPCH   QFYV +G+LSCQ+YQ
Sbjct: 160 GETLDQLKDVIEMIKKTPDSRRLIVSAWNPEDVPSMALPPCHTLFQFYVADGKLSCQLYQ 219

Query: 384 RSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHVIGDAHVYSTHVQALEEQLQKQPK 205
           RS D+ LG+PFNIASYSLLT +IA  C L  GEFVH IGDAH+Y+ H + +E+QL ++P+
Sbjct: 220 RSGDIFLGIPFNIASYSLLTHLIAHECGLEVGEFVHTIGDAHIYTNHFEQVEKQLAREPR 279

Query: 204 PFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKMAV 88
           PFP L +NP  K +  F   D  +  YDPH  I+  +AV
Sbjct: 280 PFPKLTLNPDVKSVFDFEMEDLTIEGYDPHPAIKAPVAV 318
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>TYSY_BACCR (Q81E05) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 318

 Score =  194 bits (492), Expect = 2e-49
 Identities = 90/159 (56%), Positives = 113/159 (71%)
 Frame = -2

Query: 564 GKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMALPPCHMFAQFYVENGELSCQMYQ 385
           G+  DQL DVI  IK  PD RR+I+SAWNP D+  MALPPCH   QFYV +G+LSCQ+YQ
Sbjct: 160 GETLDQLKDVIEMIKKTPDSRRLIVSAWNPEDVPSMALPPCHTLFQFYVADGKLSCQLYQ 219

Query: 384 RSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHVIGDAHVYSTHVQALEEQLQKQPK 205
           RS D+ LG+PFNIASYSLLT +IA  C L  GEFVH IGDAH+Y+ H + +E+QL ++P+
Sbjct: 220 RSGDIFLGIPFNIASYSLLTHLIAHECGLEVGEFVHTIGDAHIYTNHFEQVEKQLAREPR 279

Query: 204 PFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKMAV 88
           PFP L +NP  K +  F   D  +  YDPH  I+  +AV
Sbjct: 280 PFPKLTLNPDVKSVFDFEMEDLTIEGYDPHPAIKAPVAV 318
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>TYSY_BACC1 (Q738X7) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 318

 Score =  194 bits (492), Expect = 2e-49
 Identities = 90/159 (56%), Positives = 113/159 (71%)
 Frame = -2

Query: 564 GKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMALPPCHMFAQFYVENGELSCQMYQ 385
           G+  DQL DVI  IK  PD RR+I+SAWNP D+  MALPPCH   QFYV +G+LSCQ+YQ
Sbjct: 160 GETLDQLKDVIEMIKKTPDSRRLIVSAWNPEDVPSMALPPCHTLFQFYVADGKLSCQLYQ 219

Query: 384 RSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHVIGDAHVYSTHVQALEEQLQKQPK 205
           RS D+ LG+PFNIASYSLLT +IA  C L  GEFVH IGDAH+Y+ H + +E+QL ++P+
Sbjct: 220 RSGDIFLGIPFNIASYSLLTHLIAHECGLEVGEFVHTIGDAHIYTNHFEQVEKQLAREPR 279

Query: 204 PFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKMAV 88
           PFP L +NP  K +  F   D  +  YDPH  I+  +AV
Sbjct: 280 PFPKLTLNPDVKSVFDFEMEDLTIEGYDPHPAIKAPVAV 318
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>TYSY_BACAN (Q81R23) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 318

 Score =  194 bits (492), Expect = 2e-49
 Identities = 90/159 (56%), Positives = 113/159 (71%)
 Frame = -2

Query: 564 GKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMALPPCHMFAQFYVENGELSCQMYQ 385
           G+  DQL DVI  IK  PD RR+I+SAWNP D+  MALPPCH   QFYV +G+LSCQ+YQ
Sbjct: 160 GETLDQLKDVIEMIKKTPDSRRLIVSAWNPEDVPSMALPPCHTLFQFYVADGKLSCQLYQ 219

Query: 384 RSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHVIGDAHVYSTHVQALEEQLQKQPK 205
           RS D+ LG+PFNIASYSLLT +IA  C L  GEFVH IGDAH+Y+ H + +E+QL ++P+
Sbjct: 220 RSGDIFLGIPFNIASYSLLTHLIAHECGLEVGEFVHTIGDAHIYTNHFEQVEKQLAREPR 279

Query: 204 PFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKMAV 88
           PFP L +NP  K +  F   D  +  YDPH  I+  +AV
Sbjct: 280 PFPKLTLNPDVKSVFDFEMEDLTIEGYDPHPAIKAPVAV 318
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>DRTS_CRIFA (Q23695) Bifunctional dihydrofolate reductase-thymidylate synthase|
           (DHFR-TS) [Includes: Dihydrofolate reductase (EC
           1.5.1.3); Thymidylate synthase (EC 2.1.1.45)]
          Length = 515

 Score =  194 bits (492), Expect = 2e-49
 Identities = 94/184 (51%), Positives = 129/184 (70%), Gaps = 2/184 (1%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GPVY FQ RHFGA+Y    A+Y  +G DQ+  ++  +K N  DRR++++AWNP  L KMA
Sbjct: 335 GPVYGFQWRHFGADYKGFDANYD-EGVDQIKTIVETLKTN--DRRLLVTAWNPCALHKMA 391

Query: 453 LPPCHMFAQFYV--ENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFV 280
           + PCH+  QFYV  +  ELSC +YQR  DMGLGVPFNIASY+LLT +IA+   L PGE V
Sbjct: 392 VRPCHLLGQFYVNTQTKELSCMLYQRCCDMGLGVPFNIASYALLTILIAKATGLRPGELV 451

Query: 279 HVIGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEM 100
           H +G AHVYS HV+AL+EQLQ+ P  FP+L     ++ ++ + ++D ++  Y P+  I+M
Sbjct: 452 HTLGTAHVYSNHVEALKEQLQRVPVAFPVLVFKKEREFLEDYESTDMEVVDYVPYPPIKM 511

Query: 99  KMAV 88
           +MAV
Sbjct: 512 EMAV 515
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>TYSY_ENTFA (Q834R3) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 315

 Score =  192 bits (487), Expect = 9e-49
 Identities = 95/182 (52%), Positives = 120/182 (65%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           G +Y  Q RH+  +         G   DQLA+VI  IK NPD RR+I+SAWNP D+  MA
Sbjct: 142 GNIYGAQWRHWETK--------DGSFIDQLANVIEMIKTNPDSRRLIVSAWNPEDVPSMA 193

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           LPPCH   QFYV  G+LSCQ+YQRSAD+ LGVPFNIASY+LLT +IA    L  GEFVH 
Sbjct: 194 LPPCHTMFQFYVNEGKLSCQLYQRSADVFLGVPFNIASYALLTHLIAHETGLEVGEFVHT 253

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKM 94
           +GDAH+Y  HV+ ++EQL ++ + FP L +NP K  +  F   D K+  YDPH  I+  +
Sbjct: 254 LGDAHLYQNHVEQMQEQLSREVRSFPTLVLNPDKASVFDFDMEDIKVEGYDPHPTIKAPI 313

Query: 93  AV 88
           AV
Sbjct: 314 AV 315
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>TYSY_BARHE (Q6G2S8) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 264

 Score =  191 bits (485), Expect = 2e-48
 Identities = 91/182 (50%), Positives = 123/182 (67%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GP+Y +Q R + A          G+  DQ+++++  IK  PD RR+I+SAWNP  +K+MA
Sbjct: 91  GPIYGYQWRSWPAP--------DGRHIDQISNLLMMIKKTPDSRRLIVSAWNPASIKEMA 142

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           LPPCH F QFYV +G+LSCQ+YQRSAD+ LG+PFNIASY+LLT MIAQV  L  G+F+H 
Sbjct: 143 LPPCHCFFQFYVADGKLSCQLYQRSADIFLGIPFNIASYALLTMMIAQVSGLKVGDFIHT 202

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKM 94
           +GDAH+YS H +  + QL + P   P ++INP   D+ SF   DF+L  YD    I+  +
Sbjct: 203 LGDAHLYSNHFEQAQHQLSRIPNALPFMRINPAVTDLFSFKFEDFELLNYDAQPHIKAPI 262

Query: 93  AV 88
           AV
Sbjct: 263 AV 264
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>TYSY_BACSK (Q5WDS1) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 264

 Score =  190 bits (483), Expect = 3e-48
 Identities = 89/182 (48%), Positives = 126/182 (69%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GPVY  Q R +            GK  DQ+ +V+ +IK NP+ RR+I++AWN  ++++MA
Sbjct: 91  GPVYGKQWRSWEGA--------NGKTVDQITEVVEQIKTNPNSRRLIVNAWNVAEIEEMA 142

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           L PCH   QFYV +G+LSCQ+YQRSAD+ LGVPFNI+SY+LLT M+AQVC L PGEF+H 
Sbjct: 143 LAPCHCLFQFYVNDGKLSCQLYQRSADIFLGVPFNISSYALLTMMMAQVCGLKPGEFIHT 202

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKM 94
            GDAH+Y+ H++  + QL ++PK  P + INP   D+ +F   DF+L  YDP+  I+ ++
Sbjct: 203 FGDAHLYNNHIEQTKLQLTRKPKQLPTMHINPEVTDLFAFTYDDFELKHYDPYPHIKAEV 262

Query: 93  AV 88
           +V
Sbjct: 263 SV 264
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>TYSY_BACFR (Q64PV5) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 264

 Score =  190 bits (482), Expect = 3e-48
 Identities = 94/182 (51%), Positives = 123/182 (67%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           G +Y +Q R +          Y G   DQ+++ ++ IK+NPD RRII+SAWN  DL  M 
Sbjct: 91  GHIYGYQWRSWPT--------YDGGFIDQISEAVDAIKHNPDSRRIIVSAWNVGDLDHMN 142

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           LPPCH F QFYV NG LS Q+YQRSAD+ LGVPFNIASY+LL  M+AQV  L  G+F+H 
Sbjct: 143 LPPCHAFFQFYVANGRLSLQLYQRSADIFLGVPFNIASYALLLQMMAQVTGLQAGDFIHT 202

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKM 94
           +GDAH+Y  H++ ++ QL ++P+P P +KINP  K+I  F   DF+L  YDPH  I  K+
Sbjct: 203 LGDAHIYLNHLEQVKLQLSREPRPLPQMKINPDVKNIFDFQFKDFELVNYDPHPHIAGKV 262

Query: 93  AV 88
           AV
Sbjct: 263 AV 264
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>TYSY_NITEU (Q82WU3) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 264

 Score =  189 bits (481), Expect = 4e-48
 Identities = 94/182 (51%), Positives = 120/182 (65%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GP+Y  Q R + A          G   DQ++ VI +IK  PD RR+I+SAWN  DL KM 
Sbjct: 91  GPIYGHQWRSWAAS--------DGTVIDQISQVIQQIKETPDSRRMIVSAWNVGDLDKMK 142

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           L PCH+  QFYV +G LSCQ+YQRSAD+ LGVPFNIASYSLLT MIAQ CDL PGEFVH 
Sbjct: 143 LAPCHVLFQFYVADGRLSCQLYQRSADIFLGVPFNIASYSLLTLMIAQCCDLQPGEFVHT 202

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKM 94
            GDAH+Y  H++    QL+++P+  P +++N   ++I  F   DF L  YDP+  I+  +
Sbjct: 203 FGDAHLYLNHLEQARLQLEREPRALPAMQLNSTVRNIFDFGYEDFTLHDYDPYPPIKAPV 262

Query: 93  AV 88
           AV
Sbjct: 263 AV 264
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>TYSY_BRUSU (P67043) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 264

 Score =  189 bits (480), Expect = 6e-48
 Identities = 93/182 (51%), Positives = 121/182 (66%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GPVY +Q R + A          G+  DQ+A+++  +  NP  RR+I+SAWNP  + +MA
Sbjct: 91  GPVYGYQWRSWPAP--------DGRHIDQIANLLKMLHTNPQSRRLIVSAWNPALVDEMA 142

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           LPPCH   QFYV NG LSCQ+YQRSAD+ LGVPFNIASY+LLT MIAQV  L PGEF+H 
Sbjct: 143 LPPCHCLFQFYVANGRLSCQLYQRSADIFLGVPFNIASYALLTMMIAQVTGLKPGEFIHT 202

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKM 94
           +GDAH+YS H +    QL + PK  P++ INP  KD+ +F   DF+L  Y+    I+  +
Sbjct: 203 LGDAHIYSNHFEQARLQLTRTPKKLPVMHINPDVKDLFAFRFEDFRLDGYEADPTIKAPI 262

Query: 93  AV 88
           AV
Sbjct: 263 AV 264
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>TYSY_BRUME (P67042) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 264

 Score =  189 bits (480), Expect = 6e-48
 Identities = 93/182 (51%), Positives = 121/182 (66%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GPVY +Q R + A          G+  DQ+A+++  +  NP  RR+I+SAWNP  + +MA
Sbjct: 91  GPVYGYQWRSWPAP--------DGRHIDQIANLLKMLHTNPQSRRLIVSAWNPALVDEMA 142

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           LPPCH   QFYV NG LSCQ+YQRSAD+ LGVPFNIASY+LLT MIAQV  L PGEF+H 
Sbjct: 143 LPPCHCLFQFYVANGRLSCQLYQRSADIFLGVPFNIASYALLTMMIAQVTGLKPGEFIHT 202

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKM 94
           +GDAH+YS H +    QL + PK  P++ INP  KD+ +F   DF+L  Y+    I+  +
Sbjct: 203 LGDAHIYSNHFEQARLQLTRTPKKLPVMHINPDVKDLFAFRFEDFRLDGYEADPTIKAPI 262

Query: 93  AV 88
           AV
Sbjct: 263 AV 264
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>TYSY_LACCA (P00469) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 316

 Score =  189 bits (479), Expect = 8e-48
 Identities = 95/182 (52%), Positives = 122/182 (67%), Gaps = 10/182 (5%)
 Frame = -2

Query: 603 FGAEYSDM--------HADYTGKG--FDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           F A+Y D+         A +T KG   DQL DVI +IK +P  RR+I+SAWNP D+  MA
Sbjct: 135 FAAKYGDLGLVYGSQWRAWHTSKGDTIDQLGDVIEQIKTHPYSRRLIVSAWNPEDVPTMA 194

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           LPPCH   QFYV +G+LS Q+YQRSAD+ LGVPFNIASY+LLT ++A  C L  GEF+H 
Sbjct: 195 LPPCHTLYQFYVNDGKLSLQLYQRSADIFLGVPFNIASYALLTHLVAHECGLEVGEFIHT 254

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKM 94
            GDAH+Y  H+  ++EQL + P+P P L++NP K DI  F   D KL  YDP+  I+  +
Sbjct: 255 FGDAHLYVNHLDQIKEQLSRTPRPAPTLQLNPDKHDIFDFDMKDIKLLNYDPYPAIKAPV 314

Query: 93  AV 88
           AV
Sbjct: 315 AV 316
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>TYSY_RHILO (Q98KH9) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 264

 Score =  188 bits (478), Expect = 1e-47
 Identities = 94/182 (51%), Positives = 121/182 (66%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GPVY  Q R     + D H    G   DQ+A ++ +I+ NP  RR+I+SAWNP +++ MA
Sbjct: 91  GPVYGRQWR----SWPDGH----GGSIDQIAGLLKEIRRNPQSRRLIVSAWNPAEVEAMA 142

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           LPPCH   QFYV  G LSCQ+YQRSAD+ LGVPFNIASY+LLT M+AQV  L PG+FVH 
Sbjct: 143 LPPCHCLFQFYVSEGRLSCQLYQRSADIFLGVPFNIASYALLTLMVAQVTGLKPGDFVHT 202

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKM 94
           +GDAH+YS H +   EQLQ+ P+  P + INP  KD+ +F   DF+L  Y     I+  +
Sbjct: 203 LGDAHLYSNHFEQAREQLQRTPRALPTMWINPEVKDLFAFRFEDFRLENYVADASIQAPI 262

Query: 93  AV 88
           AV
Sbjct: 263 AV 264
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>TYSY_PSEAE (Q9I6F1) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 264

 Score =  188 bits (478), Expect = 1e-47
 Identities = 91/182 (50%), Positives = 124/182 (68%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GPVY +Q R + A          G+  DQ+A+++  +K NPD RR+I+SAWNP  + +MA
Sbjct: 91  GPVYGYQWRSWPAP--------DGRHIDQIANLMAMLKKNPDSRRLIVSAWNPALIDEMA 142

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           LPPCH   QFYV +G+LSCQ+YQRSAD+ LGVPFNIASY+LLT M+AQV  L PGEF+  
Sbjct: 143 LPPCHALFQFYVADGKLSCQLYQRSADIFLGVPFNIASYALLTLMVAQVAGLQPGEFIWT 202

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKM 94
            GD H+Y+ H++  + QL ++P P P +K+NP  KD+  F   DF+L  Y+ H  I+  +
Sbjct: 203 GGDCHLYANHLEQADLQLTREPLPLPSMKLNPEVKDLFDFRFEDFELVGYEAHPHIKAPV 262

Query: 93  AV 88
           AV
Sbjct: 263 AV 264
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>TYSY_BACTN (Q8A639) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 264

 Score =  187 bits (476), Expect = 2e-47
 Identities = 94/182 (51%), Positives = 120/182 (65%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           G +Y +Q R +         DY G   DQ+++ +  IK+NPD RRII+SAWN  DLK M 
Sbjct: 91  GHIYGYQWRSW--------PDYDGGFIDQISEAVETIKHNPDSRRIIVSAWNVADLKNMN 142

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           LPPCH F QFYV +G LS Q+YQRSAD+ LGVPFNIASY+LL  M+AQV  L  GEF+H 
Sbjct: 143 LPPCHAFFQFYVADGRLSLQLYQRSADIFLGVPFNIASYALLLQMMAQVTGLKAGEFIHT 202

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKM 94
           +GDAH+Y  H+  ++ QL ++P+  P +KINP  K I  F   DF+L  YDPH  I   +
Sbjct: 203 LGDAHIYLNHLDQVKLQLSREPRALPQMKINPDVKSIYDFQFEDFELVNYDPHPHIAGIV 262

Query: 93  AV 88
           AV
Sbjct: 263 AV 264
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>TYSY_RHIME (Q92NQ5) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 264

 Score =  186 bits (471), Expect = 6e-47
 Identities = 92/182 (50%), Positives = 121/182 (66%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GPVY +Q R +            G+  DQ+A ++  +K NP+ RR I+SAWNP  + +MA
Sbjct: 91  GPVYGYQWRSWPTP--------DGRHIDQIAALVEGLKTNPNSRRHIVSAWNPALVDEMA 142

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           LPPCH   QFYV +G+LSCQ+YQRSAD+ LGVPFNIASY+LLT M+AQV  L  G+FVH 
Sbjct: 143 LPPCHCLFQFYVADGKLSCQLYQRSADIFLGVPFNIASYALLTMMVAQVTGLEAGDFVHT 202

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKM 94
           +GDAH+Y  H +  + QL + PKP P ++INP  KDI SF   DF+L  Y+    I+  +
Sbjct: 203 LGDAHIYRNHFEQAQLQLTRTPKPLPKMEINPAVKDIFSFRFEDFELVGYEADSHIKAPV 262

Query: 93  AV 88
           AV
Sbjct: 263 AV 264
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>TYSY_ACIAD (Q6FER7) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 280

 Score =  185 bits (470), Expect = 8e-47
 Identities = 91/182 (50%), Positives = 122/182 (67%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GPVY  Q R+FGA  +     Y   GFDQ+  +IN+IK NP+ RR+I+S WNP +  ++A
Sbjct: 100 GPVYGHQWRNFGATQNS-DGSYKNDGFDQIKWLINEIKTNPNSRRLIVSGWNPNEAGQVA 158

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           LPPCH   QF+V++G+LSCQ+YQRSAD+ LGVPFNIASY+LLT MIAQVC L  G+FV  
Sbjct: 159 LPPCHTLFQFFVQDGKLSCQLYQRSADVFLGVPFNIASYALLTHMIAQVCGLGVGDFVWT 218

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKM 94
            GD H+Y+ H +  + QL ++P P   LK+NP   D+  F   D ++  Y  H  I+  +
Sbjct: 219 GGDTHLYANHFEQAQLQLTREPLPLCQLKLNPEITDLFDFKFEDIEIVDYQSHPAIKAPV 278

Query: 93  AV 88
           AV
Sbjct: 279 AV 280
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>TYSY_LACPL (Q88W05) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 316

 Score =  185 bits (470), Expect = 8e-47
 Identities = 92/182 (50%), Positives = 122/182 (67%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           G VY  Q RH+            GK  DQ+A+VI  IK +PD RR+I+SAWNP D+  MA
Sbjct: 143 GDVYGAQWRHWQTRQ--------GKTIDQIANVIEMIKTHPDSRRLIVSAWNPEDVPNMA 194

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           LPPCH   QFYV +G+LSCQ+YQRS D+ LGVPFNIASY+LLT +IA+   L+ GEFVH 
Sbjct: 195 LPPCHTLFQFYVADGKLSCQLYQRSGDVFLGVPFNIASYALLTHLIAKETGLAVGEFVHT 254

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKM 94
           +GDAH+Y+ HV+ ++ QL +QP+P P L ++     I  +  SD KL+ YDP   I+  +
Sbjct: 255 LGDAHIYTNHVEQVKTQLTRQPRPAPQLTLSGAHDSIFDYQMSDIKLSGYDPAPAIKAPV 314

Query: 93  AV 88
           A+
Sbjct: 315 AI 316
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>TYSY_XYLFA (Q9PB13) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 264

 Score =  184 bits (468), Expect = 1e-46
 Identities = 91/182 (50%), Positives = 121/182 (66%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GPVY  Q R +        A   G   DQ+  ++ +IK NPD RR+++SAWN  DL +MA
Sbjct: 91  GPVYGKQWRRW--------AGADGHEIDQIRWLLEEIKRNPDSRRLVISAWNVADLPQMA 142

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           L PCH   QFYV NG+LSCQ+YQRSAD+ LGVPFNIASY+LLT M+AQV  L+ G+FVH 
Sbjct: 143 LVPCHALFQFYVANGKLSCQLYQRSADIFLGVPFNIASYALLTHMLAQVTGLAVGDFVHT 202

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKM 94
           +GDAH+Y+ HV+    QL++ P+P P+L +NP   D+  F   D  +  YDP+  I+  +
Sbjct: 203 LGDAHLYANHVEQASVQLERVPRPQPVLMLNPAVTDLFDFTYDDIVIEGYDPYPAIKAPV 262

Query: 93  AV 88
           AV
Sbjct: 263 AV 264
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>TYSY_RHOBA (Q7UID0) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 264

 Score =  183 bits (465), Expect = 3e-46
 Identities = 91/182 (50%), Positives = 113/182 (62%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GPVY  Q R +     D          DQ+A V N+I+ NP  RR+++SAWN  D+ KMA
Sbjct: 91  GPVYGHQWRSWEGANGDT--------VDQIAWVENEIRTNPRSRRLVVSAWNVADVPKMA 142

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           LPPCH+  QFYV  G LSCQ+YQRSAD+ LGVPFNIASY++LT M+A V  L PGEFVH 
Sbjct: 143 LPPCHLLFQFYVSGGRLSCQLYQRSADLFLGVPFNIASYAMLTSMMAHVTGLKPGEFVHT 202

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKM 94
           +GD H+YS H     EQL + P+P P   I      +  F   DF+L  YDPH  I+  +
Sbjct: 203 LGDVHLYSNHFDQAREQLSRTPRPLPTFHIKRDVASVTDFQFDDFELTNYDPHPHIKAPV 262

Query: 93  AV 88
           AV
Sbjct: 263 AV 264
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>TYSY_OCEIH (Q8EQG0) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 317

 Score =  182 bits (461), Expect = 9e-46
 Identities = 93/182 (51%), Positives = 118/182 (64%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           G VY  Q R++    ++          DQL DVI+ IK NP+ RR I+SAWNP D+  MA
Sbjct: 144 GSVYGKQWRNWKTTQNET--------IDQLKDVIHSIKTNPNSRRHIVSAWNPEDIPTMA 195

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           LPPCH   QFYV NG+LSCQ+YQRSAD+ LGVPFNIASY+LLT +IA  C L  G+FVH 
Sbjct: 196 LPPCHTLFQFYVSNGKLSCQLYQRSADVFLGVPFNIASYALLTHLIAHECGLEVGDFVHT 255

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKM 94
            GDAH+YS HV+ +E QL+++ + FP L IN  K  I      D  +  Y+PH  I+  +
Sbjct: 256 FGDAHIYSNHVEQVETQLEREIRDFPQLIINKDKNSIFEMDLDDLVIENYNPHPSIKAPI 315

Query: 93  AV 88
           AV
Sbjct: 316 AV 317
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>TYSY_MYCMO (Q6KIQ6) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 288

 Score =  181 bits (460), Expect = 1e-45
 Identities = 91/182 (50%), Positives = 115/182 (63%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GPVY  Q R+F              G DQL D I  IK NPD RRII+SAW   ++ KMA
Sbjct: 120 GPVYGKQWRNFN-------------GTDQLFDAIETIKKNPDSRRIIVSAWAANEISKMA 166

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           LPPCH F QFYV N +LS Q+YQRS D  LGVPFNIASYS+L  M+AQ+ +   GEF+H 
Sbjct: 167 LPPCHAFFQFYVNNNKLSLQLYQRSGDTFLGVPFNIASYSILLAMVAQITNYEVGEFIHT 226

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKM 94
           IGD H+Y  H++ +EEQL ++P   P L +N   K+ID F   D ++  Y+ H  I+ K+
Sbjct: 227 IGDTHIYLNHLEQVEEQLSRKPLKLPKLVLNKKIKNIDDFKYEDIEIIDYESHPAIKAKV 286

Query: 93  AV 88
           AV
Sbjct: 287 AV 288
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>TYSY_STAAW (P67048) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 318

 Score =  181 bits (458), Expect = 2e-45
 Identities = 91/172 (52%), Positives = 118/172 (68%)
 Frame = -2

Query: 603 FGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMALPPCHMFAQF 424
           +G ++ D   D  G  FDQL  VI +IK+NPD RR I+SAWNPT++  MALPPCH   QF
Sbjct: 149 YGKQWRDW-VDKDGNHFDQLKTVIEQIKHNPDSRRHIVSAWNPTEIDTMALPPCHTMFQF 207

Query: 423 YVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHVIGDAHVYSTH 244
           YV++G+LSCQ+YQRSAD+ LGVPFNIASY+LLT +IA+ C L  GEFVH  GDAH+YS H
Sbjct: 208 YVQDGKLSCQLYQRSADIFLGVPFNIASYALLTHLIAKECGLEVGEFVHTFGDAHIYSNH 267

Query: 243 VQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKMAV 88
           + A++ QL ++    P LKIN   K I      D ++  Y+ H  I+  +AV
Sbjct: 268 IDAIQTQLARESFNPPTLKINS-DKSIFDINYEDLEIVDYESHPAIKAPIAV 318
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>TYSY_STAAS (Q6G9D4) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 318

 Score =  181 bits (458), Expect = 2e-45
 Identities = 91/172 (52%), Positives = 118/172 (68%)
 Frame = -2

Query: 603 FGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMALPPCHMFAQF 424
           +G ++ D   D  G  FDQL  VI +IK+NPD RR I+SAWNPT++  MALPPCH   QF
Sbjct: 149 YGKQWRDW-VDKDGNHFDQLKTVIEQIKHNPDSRRHIVSAWNPTEIDTMALPPCHTMFQF 207

Query: 423 YVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHVIGDAHVYSTH 244
           YV++G+LSCQ+YQRSAD+ LGVPFNIASY+LLT +IA+ C L  GEFVH  GDAH+YS H
Sbjct: 208 YVQDGKLSCQLYQRSADIFLGVPFNIASYALLTHLIAKECGLEVGEFVHTFGDAHIYSNH 267

Query: 243 VQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKMAV 88
           + A++ QL ++    P LKIN   K I      D ++  Y+ H  I+  +AV
Sbjct: 268 IDAIQTQLARESFNPPTLKINS-DKSIFDINYEDLEIVDYESHPAIKAPIAV 318
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>TYSY_STAAR (Q6GGY0) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 318

 Score =  181 bits (458), Expect = 2e-45
 Identities = 91/172 (52%), Positives = 118/172 (68%)
 Frame = -2

Query: 603 FGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMALPPCHMFAQF 424
           +G ++ D   D  G  FDQL  VI +IK+NPD RR I+SAWNPT++  MALPPCH   QF
Sbjct: 149 YGKQWRDW-VDKDGNHFDQLKTVIEQIKHNPDSRRHIVSAWNPTEIDTMALPPCHTMFQF 207

Query: 423 YVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHVIGDAHVYSTH 244
           YV++G+LSCQ+YQRSAD+ LGVPFNIASY+LLT +IA+ C L  GEFVH  GDAH+YS H
Sbjct: 208 YVQDGKLSCQLYQRSADIFLGVPFNIASYALLTHLIAKECGLEVGEFVHTFGDAHIYSNH 267

Query: 243 VQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKMAV 88
           + A++ QL ++    P LKIN   K I      D ++  Y+ H  I+  +AV
Sbjct: 268 IDAIQTQLARESFNPPTLKINS-DKSIFDINYEDLEIVDYESHPAIKAPIAV 318
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>TYSY_STAAN (P67047) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 318

 Score =  181 bits (458), Expect = 2e-45
 Identities = 91/172 (52%), Positives = 118/172 (68%)
 Frame = -2

Query: 603 FGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMALPPCHMFAQF 424
           +G ++ D   D  G  FDQL  VI +IK+NPD RR I+SAWNPT++  MALPPCH   QF
Sbjct: 149 YGKQWRDW-VDKDGNHFDQLKTVIEQIKHNPDSRRHIVSAWNPTEIDTMALPPCHTMFQF 207

Query: 423 YVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHVIGDAHVYSTH 244
           YV++G+LSCQ+YQRSAD+ LGVPFNIASY+LLT +IA+ C L  GEFVH  GDAH+YS H
Sbjct: 208 YVQDGKLSCQLYQRSADIFLGVPFNIASYALLTHLIAKECGLEVGEFVHTFGDAHIYSNH 267

Query: 243 VQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKMAV 88
           + A++ QL ++    P LKIN   K I      D ++  Y+ H  I+  +AV
Sbjct: 268 IDAIQTQLARESFNPPTLKINS-DKSIFDINYEDLEIVDYESHPAIKAPIAV 318
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>TYSY_STAAM (P67046) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 318

 Score =  181 bits (458), Expect = 2e-45
 Identities = 91/172 (52%), Positives = 118/172 (68%)
 Frame = -2

Query: 603 FGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMALPPCHMFAQF 424
           +G ++ D   D  G  FDQL  VI +IK+NPD RR I+SAWNPT++  MALPPCH   QF
Sbjct: 149 YGKQWRDW-VDKDGNHFDQLKTVIEQIKHNPDSRRHIVSAWNPTEIDTMALPPCHTMFQF 207

Query: 423 YVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHVIGDAHVYSTH 244
           YV++G+LSCQ+YQRSAD+ LGVPFNIASY+LLT +IA+ C L  GEFVH  GDAH+YS H
Sbjct: 208 YVQDGKLSCQLYQRSADIFLGVPFNIASYALLTHLIAKECGLEVGEFVHTFGDAHIYSNH 267

Query: 243 VQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKMAV 88
           + A++ QL ++    P LKIN   K I      D ++  Y+ H  I+  +AV
Sbjct: 268 IDAIQTQLARESFNPPTLKINS-DKSIFDINYEDLEIVDYESHPAIKAPIAV 318
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>TYSY_STAAC (Q5HFZ6) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 318

 Score =  181 bits (458), Expect = 2e-45
 Identities = 91/172 (52%), Positives = 118/172 (68%)
 Frame = -2

Query: 603 FGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMALPPCHMFAQF 424
           +G ++ D   D  G  FDQL  VI +IK+NPD RR I+SAWNPT++  MALPPCH   QF
Sbjct: 149 YGKQWRDW-VDKDGNHFDQLKTVIEQIKHNPDSRRHIVSAWNPTEIDTMALPPCHTMFQF 207

Query: 423 YVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHVIGDAHVYSTH 244
           YV++G+LSCQ+YQRSAD+ LGVPFNIASY+LLT +IA+ C L  GEFVH  GDAH+YS H
Sbjct: 208 YVQDGKLSCQLYQRSADIFLGVPFNIASYALLTHLIAKECGLEVGEFVHTFGDAHIYSNH 267

Query: 243 VQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKMAV 88
           + A++ QL ++    P LKIN   K I      D ++  Y+ H  I+  +AV
Sbjct: 268 IDAIQTQLARESFNPPTLKINS-DKSIFDINYEDLEIVDYESHPAIKAPIAV 318
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>TYSY_XYLFT (Q87BT4) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 264

 Score =  180 bits (457), Expect = 3e-45
 Identities = 90/182 (49%), Positives = 119/182 (65%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GPVY  Q R +        A   G   DQ+  ++ +IK NPD RR+++SAWN  DL +MA
Sbjct: 91  GPVYGKQWRRW--------AGADGHEIDQIRWLVEEIKRNPDSRRLVISAWNVADLPQMA 142

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           L PCH   QFYV NG+LSCQ+YQRSAD+ LGVPFNIASY+LLT M+AQV  L  G+FVH 
Sbjct: 143 LVPCHALFQFYVANGKLSCQLYQRSADIFLGVPFNIASYALLTHMLAQVTGLVVGDFVHT 202

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKM 94
           +GDAH+Y+ HV+    QL + P+P P+L++N    D+  F   D  +  YDP+  I+  +
Sbjct: 203 LGDAHLYANHVEQASVQLGRVPRPQPVLRLNQAVTDLFDFTYDDIVIEGYDPYPAIKAPV 262

Query: 93  AV 88
           AV
Sbjct: 263 AV 264
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>TYSY_AGRT5 (Q8UDS3) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 264

 Score =  180 bits (457), Expect = 3e-45
 Identities = 89/182 (48%), Positives = 120/182 (65%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GPVY  Q R + A          G+  DQ+A +I  +K NP+ RR I+SAWNP  + +MA
Sbjct: 91  GPVYGAQWRSWPAP--------DGRHIDQIALLIEALKTNPNSRRHIVSAWNPALVDEMA 142

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           LPPCH   QFYV +G+LSCQ+YQRSAD+ LGVPFNIASY+LLT M+AQV  L PG+FVH 
Sbjct: 143 LPPCHCLFQFYVSDGKLSCQLYQRSADIFLGVPFNIASYALLTLMVAQVVGLKPGDFVHT 202

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKM 94
           +GDAH+Y+ H +  + Q+ + PK  P +++NP  K++  F   DF L  Y+    I+  +
Sbjct: 203 LGDAHIYANHFEQAQLQMTRTPKALPTMRLNPDVKNLFGFKFEDFTLENYEADSSIKAPI 262

Query: 93  AV 88
           AV
Sbjct: 263 AV 264
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>TYSY_MYCGA (Q9XC19) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 289

 Score =  180 bits (457), Expect = 3e-45
 Identities = 94/183 (51%), Positives = 120/183 (65%), Gaps = 1/183 (0%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GPVY  Q R F              G DQ+  VIN+IK NP  RR+I+SAWNP ++K+MA
Sbjct: 120 GPVYGKQWRDFN-------------GVDQIEWVINEIKTNPFSRRLIVSAWNPGEIKEMA 166

Query: 453 LPPCHMFAQFYV-ENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVH 277
           LPPCH F QF+V E  E+S Q+YQRS D+ LGVPFNIASYSLL  M+AQV  L P EF+H
Sbjct: 167 LPPCHSFFQFFVNEKYEISLQLYQRSGDLFLGVPFNIASYSLLLLMVAQVTGLKPAEFIH 226

Query: 276 VIGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMK 97
            IGD H+YS H++ ++ QLQ++PK  P + +NP  K+I  F   D  L  Y+ H  I+ K
Sbjct: 227 TIGDTHIYSNHLEQVKIQLQREPKKLPKVTLNPDIKNIFDFRFEDISLENYEHHDPIKGK 286

Query: 96  MAV 88
           +AV
Sbjct: 287 VAV 289
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>TYSY_BARQU (Q6FZ91) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 264

 Score =  180 bits (456), Expect = 4e-45
 Identities = 89/182 (48%), Positives = 119/182 (65%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GP+Y +Q R + A          G+  DQ++ ++  IK  PD RR+I+SAWNP  +++MA
Sbjct: 91  GPIYGYQWRSWPAS--------DGRYIDQISRLLTMIKKTPDSRRLIVSAWNPALIEEMA 142

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           LPPCH F QFYV + +LSCQ+YQRSAD+ LGVPFNIASY+LLT MIAQV  L  G+F+H 
Sbjct: 143 LPPCHCFFQFYVADDKLSCQLYQRSADIFLGVPFNIASYALLTMMIAQVSGLKAGDFIHT 202

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKM 94
           +GDAH+YS H +    QL + P   P + INP   D+ SF   DF+L  Y+    I+  +
Sbjct: 203 LGDAHLYSNHFEQARYQLSRIPNALPSMLINPSVTDLFSFKFEDFELLNYEAQPHIKAPV 262

Query: 93  AV 88
           AV
Sbjct: 263 AV 264
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>TYSY_SHEON (Q8EH94) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 264

 Score =  178 bits (452), Expect = 1e-44
 Identities = 89/182 (48%), Positives = 120/182 (65%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GPVY  Q R +  +        +G+  DQ++ VI +IK+ PD RR+I+SAWN  +L KMA
Sbjct: 91  GPVYGAQWRSWPTQ--------SGEAIDQISQVIAQIKSQPDSRRLIVSAWNVGELDKMA 142

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           L PCH F QFYV +G+LSCQ+YQRS D+ LG+PFNIASY+LLT M+AQ CDL+ G+FV  
Sbjct: 143 LAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLTMMVAQQCDLALGDFVWT 202

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKM 94
            GD H+YS H++    QL ++P+P P + I      I  +   DF L+ YDPH  I+  +
Sbjct: 203 GGDTHLYSNHMEQTALQLSREPRPLPTMTILRKPASIFDYQFDDFALSNYDPHPHIKAPV 262

Query: 93  AV 88
           AV
Sbjct: 263 AV 264
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>TYSY_XANCP (Q8PCE7) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 264

 Score =  178 bits (451), Expect = 1e-44
 Identities = 88/182 (48%), Positives = 118/182 (64%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GPVY  Q R +            G   DQ+  ++++IK NPD RR+++SAWN  +L +MA
Sbjct: 91  GPVYGKQWRRWTGP--------DGVEIDQMQWLVDEIKRNPDSRRLVISAWNVGELPQMA 142

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           L PCH   QFYV +G+LSCQ+YQRS D+ LGVPFNIASY+LLT M+AQ   L  G+FVH 
Sbjct: 143 LMPCHSLFQFYVVDGKLSCQLYQRSGDIFLGVPFNIASYALLTHMVAQATGLGVGDFVHT 202

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKM 94
           +GDAH+YS H +   EQL + P+P P L++NP   D+ +F   D  +  YDPH  I+  +
Sbjct: 203 LGDAHLYSNHFEQAREQLTRTPRPLPTLRLNPDVTDLFAFRFEDIAIDGYDPHPAIKAPV 262

Query: 93  AV 88
           AV
Sbjct: 263 AV 264
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>TYSY_ONYPE (Q6YQT0) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 288

 Score =  177 bits (450), Expect = 2e-44
 Identities = 84/169 (49%), Positives = 116/169 (68%)
 Frame = -2

Query: 630 PVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMAL 451
           P++  +  + G  Y     D+ G   DQ+  +I++IK NP+ RR+IL++WNP  L +MAL
Sbjct: 110 PLFAIKHGNLGPVYGKQWRDFNG--VDQIKFLISEIKTNPNSRRLILNSWNPPLLNQMAL 167

Query: 450 PPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHVI 271
           PPCH+  QFYV  G+LS Q+YQRS D+ LG+PFNIASYSLL  M+AQV +L P EF+H +
Sbjct: 168 PPCHVLIQFYVHQGKLSLQLYQRSGDVFLGIPFNIASYSLLLMMVAQVTNLQPYEFIHTL 227

Query: 270 GDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACY 124
           GDAH+YS H+  ++ Q+Q+ PK  P + +NP  K+ID F  SDF L  Y
Sbjct: 228 GDAHIYSNHLAQVQTQIQRTPKKLPQMILNPDIKNIDDFKFSDFTLQNY 276
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>TYSY_XANAC (Q8PP46) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 264

 Score =  177 bits (449), Expect = 2e-44
 Identities = 88/182 (48%), Positives = 117/182 (64%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GPVY  Q R +            G   DQ+  ++++IK NPD RR+++SAWN  +L +MA
Sbjct: 91  GPVYGKQWRRWTGP--------DGVEIDQMQWLVDEIKRNPDSRRLVISAWNVGELPQMA 142

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           L PCH   QFYV NG+LSCQ+YQRS D+ LGVPFNIASY+LLT M+AQ   L  G+FVH 
Sbjct: 143 LMPCHSLFQFYVVNGKLSCQLYQRSGDIFLGVPFNIASYALLTHMVAQATGLGVGDFVHT 202

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKM 94
           +GDAH+YS H +   EQL + P+  P L++NP   D+ +F   D  +  YDPH  I+  +
Sbjct: 203 LGDAHLYSNHFEQAREQLTRTPRALPSLRLNPEVTDLFAFRFEDIAIEGYDPHPAIKAPV 262

Query: 93  AV 88
           AV
Sbjct: 263 AV 264
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>TYSY_PORGI (Q7MTB5) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 264

 Score =  177 bits (448), Expect = 3e-44
 Identities = 86/182 (47%), Positives = 115/182 (63%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GP+Y +Q R +         DY G   DQ+ +V+ +++  PD RRII+ +WN   L  M 
Sbjct: 91  GPIYGYQWRSW--------PDYRGGHIDQMQEVLRQLREEPDSRRIIVCSWNVGQLADMH 142

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           LPPCH F QFYV +G LS Q+YQRSAD  LG+PFNIASY+LL  MIA V  L PG FVH 
Sbjct: 143 LPPCHCFMQFYVADGRLSLQLYQRSADSFLGIPFNIASYALLLQMIAHVTGLKPGRFVHT 202

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKM 94
           +GDAH+Y  H++ ++ QL ++P+  P + +NP   D+  F   DF+L  YDPH  I   +
Sbjct: 203 LGDAHIYLNHLEQVQLQLSREPRALPRMVLNPEVSDLFDFRYEDFRLEGYDPHPHIAGVV 262

Query: 93  AV 88
           AV
Sbjct: 263 AV 264
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>TYSY_AZOSE (Q5P233) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 264

 Score =  177 bits (448), Expect = 3e-44
 Identities = 90/182 (49%), Positives = 115/182 (63%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GPVY  Q R +            G   DQ+A +I+ +K+NPD RR ++SAWNP ++  MA
Sbjct: 91  GPVYGKQWRRWETA--------NGATIDQIAQLIDGLKHNPDSRRHLVSAWNPGEVAGMA 142

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           LPPCH   QFYV    LSCQ+YQRSAD+ LGVPFNIASY+LLT M+AQVC L  G+FV  
Sbjct: 143 LPPCHALFQFYVAGDRLSCQLYQRSADIFLGVPFNIASYALLTLMVAQVCGLRAGDFVWT 202

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKM 94
            GD H+Y  H+     QL +QP+  P + +NP   DI  F   DF+L  YDPH  I+ ++
Sbjct: 203 GGDCHLYLNHLDQARLQLSRQPRALPRMIVNPGVTDIFGFRFEDFRLEGYDPHPHIKAEV 262

Query: 93  AV 88
           AV
Sbjct: 263 AV 264
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>TYSY_LACAC (Q5FKL6) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 318

 Score =  176 bits (447), Expect = 4e-44
 Identities = 90/182 (49%), Positives = 116/182 (63%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           G VY  Q RH+            G   DQ+ +VI +IKNNPD RR+I++AWNP D+   A
Sbjct: 145 GDVYGAQWRHWQKR--------DGSFIDQIENVIEQIKNNPDSRRMIVTAWNPEDVPTSA 196

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           LPPCH+  QFYV +G++S Q+YQRS DM LGVPFNIASY+LL  MIA+   L  GEF+H 
Sbjct: 197 LPPCHVMFQFYVVDGKISVQLYQRSGDMFLGVPFNIASYALLLNMIARETGLQVGEFIHT 256

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKM 94
           +GDAH+YS H   ++E L ++P   P L +NP KK I+ F   D KL  Y  H  I+  +
Sbjct: 257 LGDAHIYSNHFSQVKEMLSRKPYESPQLWLNPEKKHIEDFDMQDIKLVDYKHHGTIKAPV 316

Query: 93  AV 88
           AV
Sbjct: 317 AV 318
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>TYSY_CAUCR (Q9A6H0) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 279

 Score =  176 bits (446), Expect = 5e-44
 Identities = 89/182 (48%), Positives = 119/182 (65%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GPVY  Q R +        A   G+  DQ++ ++  +K NP+ RR I++AWNP D+  MA
Sbjct: 107 GPVYGKQWRSW--------ATPDGRVIDQISALVENLKANPNSRRHIVTAWNPADVDDMA 158

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           LPPCH   QF+V +G+LSCQ+YQRSAD+ LGVPFNIASY+LLT M+A+V  L PGEFVH 
Sbjct: 159 LPPCHCLFQFFVADGKLSCQLYQRSADVFLGVPFNIASYALLTLMVAKVVGLEPGEFVHT 218

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKM 94
            GDAH+Y  H+    EQL ++P  FP +KI   K+D+  F   DF L  Y  H  I+ ++
Sbjct: 219 FGDAHLYLNHLDQAREQLTREPFDFPTMKIAD-KRDLFGFEYEDFTLEGYQAHPHIKAEV 277

Query: 93  AV 88
           +V
Sbjct: 278 SV 279
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>TYSB_BACSU (P11044) Thymidylate synthase B (EC 2.1.1.45) (TS B) (TSase B)|
          Length = 264

 Score =  176 bits (445), Expect = 7e-44
 Identities = 88/183 (48%), Positives = 119/183 (65%), Gaps = 1/183 (0%)
 Frame = -2

Query: 633 GPVYXFQXRHF-GAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKM 457
           GPVY  Q R + GA+         G+  DQ++ +I  IK NP+ RR+I+SAWN  ++ KM
Sbjct: 91  GPVYGSQWRSWRGAD---------GETIDQISRLIEDIKTNPNSRRLIVSAWNVGEIDKM 141

Query: 456 ALPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVH 277
           ALPPCH   QFYV +G+LSCQ+YQRSAD+ LGVPFNIASY+LLT +IA V  L PGEF+H
Sbjct: 142 ALPPCHCLFQFYVSDGKLSCQLYQRSADVFLGVPFNIASYALLTMIIAHVTGLEPGEFIH 201

Query: 276 VIGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMK 97
             GD H+Y  H++ +  QL++  +P P L+       I +F   DF +  YDPH  I+  
Sbjct: 202 TFGDVHIYQNHIEQVNLQLERDVRPLPQLRFARKVDSIFNFAFEDFIIEDYDPHPHIKGA 261

Query: 96  MAV 88
           ++V
Sbjct: 262 VSV 264
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>TYSY_XANOR (Q5GWB5) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 264

 Score =  175 bits (444), Expect = 9e-44
 Identities = 87/182 (47%), Positives = 116/182 (63%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GPVY  Q R +            G   DQ+  ++++IK NPD RR+++SAWN  +L +MA
Sbjct: 91  GPVYGKQWRRWTGP--------DGVEIDQMQWLVDEIKRNPDSRRLVISAWNVGELPQMA 142

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           L PCH   QFYV NG+LSCQ+YQRS D+ LGVPFNIASY+LLT M+AQ   L  G+FVH 
Sbjct: 143 LMPCHSLFQFYVVNGKLSCQLYQRSGDIFLGVPFNIASYALLTHMVAQATGLGVGDFVHT 202

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKM 94
           +GDAH+YS H     +QL + P+  P L++NP   D+ +F   D  +  YDPH  I+  +
Sbjct: 203 LGDAHLYSNHFDQARKQLTRTPRALPTLRLNPEVTDLFAFRFEDIAIEGYDPHPAIKAPV 262

Query: 93  AV 88
           AV
Sbjct: 263 AV 264
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>TYSB_BACAM (P54081) Thymidylate synthase B (EC 2.1.1.45) (TS B) (TSase B)|
          Length = 264

 Score =  175 bits (443), Expect = 1e-43
 Identities = 90/183 (49%), Positives = 118/183 (64%), Gaps = 1/183 (0%)
 Frame = -2

Query: 633 GPVYXFQXRHF-GAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKM 457
           GPVY  Q R + GA+         G+  DQ++ +I+ IK NP+ RR+I+SAWN  ++ +M
Sbjct: 91  GPVYGSQWRSWRGAD---------GETIDQISRLIHDIKTNPNSRRLIVSAWNVGEIDRM 141

Query: 456 ALPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVH 277
           ALPPCH   QFYV +G+LSCQ+YQRSAD+ LGVPFNIASY+LLT MIA V  L PGEFVH
Sbjct: 142 ALPPCHCLFQFYVADGKLSCQLYQRSADVFLGVPFNIASYALLTMMIAHVTGLEPGEFVH 201

Query: 276 VIGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMK 97
             GD H+Y  HV+ +  QL +  +P P L+       I  F   DF +  YDPH  I+  
Sbjct: 202 TFGDVHIYQNHVEQVNLQLTRDVRPLPKLRFARNVDSIFDFAFEDFIIEDYDPHPHIKGA 261

Query: 96  MAV 88
           ++V
Sbjct: 262 VSV 264
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>TYSY_ECOLI (P0A884) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 264

 Score =  174 bits (442), Expect = 1e-43
 Identities = 88/182 (48%), Positives = 117/182 (64%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GPVY  Q R +            G+  DQ+  V+N++KN+PD RRII+SAWN  +L KMA
Sbjct: 91  GPVYGKQWRAWPTP--------DGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMA 142

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           L PCH F QFYV +G+LSCQ+YQRS D+ LG+PFNIASY+LL  M+AQ CDL  G+FV  
Sbjct: 143 LAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWT 202

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKM 94
            GD H+YS H+     QL ++P+P P L I    + I  +   DF++  YDPH  I+  +
Sbjct: 203 GGDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPV 262

Query: 93  AV 88
           A+
Sbjct: 263 AI 264
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>TYSY_ECOL6 (P0A885) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 264

 Score =  174 bits (442), Expect = 1e-43
 Identities = 88/182 (48%), Positives = 117/182 (64%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GPVY  Q R +            G+  DQ+  V+N++KN+PD RRII+SAWN  +L KMA
Sbjct: 91  GPVYGKQWRAWPTP--------DGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMA 142

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           L PCH F QFYV +G+LSCQ+YQRS D+ LG+PFNIASY+LL  M+AQ CDL  G+FV  
Sbjct: 143 LAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWT 202

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKM 94
            GD H+YS H+     QL ++P+P P L I    + I  +   DF++  YDPH  I+  +
Sbjct: 203 GGDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPV 262

Query: 93  AV 88
           A+
Sbjct: 263 AI 264
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>TYSY_ECO57 (P0A886) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 264

 Score =  174 bits (442), Expect = 1e-43
 Identities = 88/182 (48%), Positives = 117/182 (64%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GPVY  Q R +            G+  DQ+  V+N++KN+PD RRII+SAWN  +L KMA
Sbjct: 91  GPVYGKQWRAWPTP--------DGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMA 142

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           L PCH F QFYV +G+LSCQ+YQRS D+ LG+PFNIASY+LL  M+AQ CDL  G+FV  
Sbjct: 143 LAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWT 202

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKM 94
            GD H+YS H+     QL ++P+P P L I    + I  +   DF++  YDPH  I+  +
Sbjct: 203 GGDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPV 262

Query: 93  AV 88
           A+
Sbjct: 263 AI 264
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>TYSY_COREF (Q8FR47) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 267

 Score =  174 bits (441), Expect = 2e-43
 Identities = 87/182 (47%), Positives = 116/182 (63%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GPVY  Q R +            G+  DQ++  +  +KNNPD RR I+SAWN ++L+ MA
Sbjct: 95  GPVYGVQWRSWPTP--------DGRHIDQISRALEMLKNNPDSRRNIVSAWNVSELENMA 146

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           LPPCH+  Q YV +G+LSCQ+YQRSADM LGVPFNIASY+LLT M AQ  DL  GEF+  
Sbjct: 147 LPPCHLLFQLYVADGKLSCQLYQRSADMFLGVPFNIASYALLTHMFAQQADLEVGEFIWT 206

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKM 94
            GD H+Y  H + ++EQL +  +P+P L++N      D +   D  ++ YDPH  I  K+
Sbjct: 207 GGDCHIYDNHTEQVDEQLSRAARPYPTLELNKAASLFD-YTFEDIAVSNYDPHPLIRGKV 265

Query: 93  AV 88
           AV
Sbjct: 266 AV 267
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>TYSY_SHIFL (P48464) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 264

 Score =  174 bits (441), Expect = 2e-43
 Identities = 87/182 (47%), Positives = 117/182 (64%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GPVY  Q R +            G+  DQ+  V+N++KN+PD RRII+SAWN  +L KMA
Sbjct: 91  GPVYGKQWRAWPTP--------DGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMA 142

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           L PCH F QFYV +G+LSCQ+YQRS D+ LG+PFNIASY+LL  M+AQ CDL  G+FV  
Sbjct: 143 LAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWT 202

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKM 94
            GD H+YS H+     QL ++P+P P L I    + I  +   DF++  YDPH  ++  +
Sbjct: 203 GGDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGVKAPV 262

Query: 93  AV 88
           A+
Sbjct: 263 AI 264
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>TYSY_YERPS (Q667F9) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 264

 Score =  174 bits (440), Expect = 3e-43
 Identities = 88/182 (48%), Positives = 120/182 (65%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GP+Y  Q R +GA      AD  G+  DQL++V+N++K +PD RRII+SAWN  +L +MA
Sbjct: 91  GPIYGKQWRAWGA------AD--GRKIDQLSNVVNQLKQDPDSRRIIVSAWNVGELDQMA 142

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           L PCH F QFYV +G+LSCQ+YQRS D+ LG+PFNIASY+LL  M+AQ CDL+ G+FV  
Sbjct: 143 LAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLAVGDFVWT 202

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKM 94
            GD H+YS H+     QL ++P+  P L I      +  +   DF +  YDPH  I+  +
Sbjct: 203 GGDTHLYSNHIDQTHLQLSREPRALPKLVIKRKPDSLFDYHFDDFDIEGYDPHPGIKAPI 262

Query: 93  AV 88
           A+
Sbjct: 263 AI 264
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>TYSY_STAES (P0C0M5) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 318

 Score =  174 bits (440), Expect = 3e-43
 Identities = 87/172 (50%), Positives = 114/172 (66%)
 Frame = -2

Query: 603 FGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMALPPCHMFAQF 424
           +G ++ D   D  G  +DQL  VI +IK NP+ RR I+SAWNPT++  MALPPCH   QF
Sbjct: 149 YGKQWRDWE-DKNGNHYDQLKSVIQQIKTNPNSRRHIVSAWNPTEIDSMALPPCHTMFQF 207

Query: 423 YVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHVIGDAHVYSTH 244
           YV+ G+L+CQ+YQRSAD+ LGVPFNIASY+LLT ++A+ C L  GEF+H  GDAH+YS H
Sbjct: 208 YVQEGKLNCQLYQRSADIFLGVPFNIASYALLTHLVAKECGLEVGEFIHTFGDAHIYSNH 267

Query: 243 VQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKMAV 88
           + A+  QL +     P LKIN   K I      D +L  Y+ H  I+  +AV
Sbjct: 268 MDAIHTQLSRDSYLPPQLKIN-TDKSIFDINYEDLELINYESHPAIKAPIAV 318
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>TYSY_STAEQ (Q5HMP6) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 318

 Score =  174 bits (440), Expect = 3e-43
 Identities = 87/172 (50%), Positives = 114/172 (66%)
 Frame = -2

Query: 603 FGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMALPPCHMFAQF 424
           +G ++ D   D  G  +DQL  VI +IK NP+ RR I+SAWNPT++  MALPPCH   QF
Sbjct: 149 YGKQWRDWE-DKNGNHYDQLKSVIQQIKTNPNSRRHIVSAWNPTEIDSMALPPCHTMFQF 207

Query: 423 YVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHVIGDAHVYSTH 244
           YV+ G+L+CQ+YQRSAD+ LGVPFNIASY+LLT ++A+ C L  GEF+H  GDAH+YS H
Sbjct: 208 YVQEGKLNCQLYQRSADIFLGVPFNIASYALLTHLVAKECGLEVGEFIHTFGDAHIYSNH 267

Query: 243 VQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKMAV 88
           + A+  QL +     P LKIN   K I      D +L  Y+ H  I+  +AV
Sbjct: 268 MDAIHTQLSRDSYLPPQLKIN-TDKSIFDINYEDLELINYESHPAIKAPIAV 318
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>TYSY_STAAU (P0A0M5) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 318

 Score =  174 bits (440), Expect = 3e-43
 Identities = 87/172 (50%), Positives = 114/172 (66%)
 Frame = -2

Query: 603 FGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMALPPCHMFAQF 424
           +G ++ D   D  G  +DQL  VI +IK NP+ RR I+SAWNPT++  MALPPCH   QF
Sbjct: 149 YGKQWRDWE-DKNGNHYDQLKSVIQQIKTNPNSRRHIVSAWNPTEIDSMALPPCHTMFQF 207

Query: 423 YVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHVIGDAHVYSTH 244
           YV+ G+L+CQ+YQRSAD+ LGVPFNIASY+LLT ++A+ C L  GEF+H  GDAH+YS H
Sbjct: 208 YVQEGKLNCQLYQRSADIFLGVPFNIASYALLTHLVAKECGLEVGEFIHTFGDAHIYSNH 267

Query: 243 VQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKMAV 88
           + A+  QL +     P LKIN   K I      D +L  Y+ H  I+  +AV
Sbjct: 268 MDAIHTQLSRDSYLPPQLKIN-TDKSIFDINYEDLELINYESHPAIKAPIAV 318
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>TYSY_BIFLO (Q8G3T9) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 266

 Score =  174 bits (440), Expect = 3e-43
 Identities = 90/182 (49%), Positives = 118/182 (64%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GPVY  Q R + A   +       +  DQ+++V++ IK++PD RR+I+SAWNP +++KMA
Sbjct: 90  GPVYGVQWRSWPAPTPED----PNRTIDQISNVLDLIKHHPDSRRMIVSAWNPAEVEKMA 145

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           LPPCH   QFYV + +LSCQ+YQRS DM LGVPFNIASYSLLT M+AQ   L PGEFV  
Sbjct: 146 LPPCHALFQFYVADDKLSCQLYQRSCDMFLGVPFNIASYSLLTMMMAQQAGLKPGEFVWT 205

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKM 94
            GD HVY  HV    EQL ++P P+P ++I       D +   DFK+  Y  H  I+  +
Sbjct: 206 GGDCHVYDNHVDQFLEQLGRKPYPYPTIEIRKADSLFD-YQYEDFKVVGYQHHPTIKAPV 264

Query: 93  AV 88
           AV
Sbjct: 265 AV 266
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>TYSY_LISMO (Q8Y626) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 314

 Score =  173 bits (439), Expect = 3e-43
 Identities = 82/159 (51%), Positives = 111/159 (69%)
 Frame = -2

Query: 564 GKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMALPPCHMFAQFYVENGELSCQMYQ 385
           G+  DQLAD+I  IK NP+ RR+I+SAWNP D+  MALPPCH   QFYV +G+LSCQ+YQ
Sbjct: 156 GETIDQLADLIEMIKTNPNSRRLIVSAWNPEDIPNMALPPCHSLFQFYVADGKLSCQLYQ 215

Query: 384 RSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHVIGDAHVYSTHVQALEEQLQKQPK 205
           RSAD+ LGVPFNIASY+LLT +IA+   L  GEF+H +GDAH+Y+ H++ ++EQL + P 
Sbjct: 216 RSADIFLGVPFNIASYALLTHLIAREVGLDVGEFIHTMGDAHLYNNHIEQVKEQLSRTPH 275

Query: 204 PFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKMAV 88
             P L ++     I  F  +D  L  Y+P   I+  ++V
Sbjct: 276 ALPKLVLSDKPATIFDFEVADISLDGYNPDPSIKAPISV 314
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>TYSY_YERPE (Q8ZHV1) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 264

 Score =  173 bits (439), Expect = 3e-43
 Identities = 88/182 (48%), Positives = 120/182 (65%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GP+Y  Q R +GA      AD  G+  DQL++V+N++K +PD RRII+SAWN  +L +MA
Sbjct: 91  GPIYGKQWRAWGA------AD--GRKIDQLSNVVNQLKQDPDSRRIIVSAWNVGELDQMA 142

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           L PCH F QFYV +G+LSCQ+YQRS D+ LG+PFNIASY+LL  M+AQ CDL+ G+FV  
Sbjct: 143 LAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLAVGDFVWT 202

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKM 94
            GD H+YS H+     QL ++P+  P L I      +  +   DF +  YDPH  I+  +
Sbjct: 203 GGDTHLYSNHIDQAHLQLSREPRVLPKLVIKRKPDSLFDYHFDDFDIEGYDPHPGIKAPI 262

Query: 93  AV 88
           A+
Sbjct: 263 AI 264
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>TYSY_LISIN (Q92AD4) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 314

 Score =  173 bits (438), Expect = 4e-43
 Identities = 82/159 (51%), Positives = 111/159 (69%)
 Frame = -2

Query: 564 GKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMALPPCHMFAQFYVENGELSCQMYQ 385
           G+  DQLAD+I  IK NP+ RR+I+SAWNP D+  MALPPCH   QFYV +G+LSCQ+YQ
Sbjct: 156 GETIDQLADLIEMIKTNPNSRRLIVSAWNPEDIPNMALPPCHSLFQFYVADGKLSCQLYQ 215

Query: 384 RSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHVIGDAHVYSTHVQALEEQLQKQPK 205
           RSAD+ LGVPFNIASY+LLT +IA+   L  GEF+H +GDAH+Y+ H++ ++EQL + P 
Sbjct: 216 RSADIFLGVPFNIASYALLTHLIAREVGLDVGEFIHTMGDAHLYNNHIEQVKEQLSRTPH 275

Query: 204 PFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKMAV 88
             P L ++     I  F  +D  L  Y+P   I+  ++V
Sbjct: 276 ALPKLVLSDKPATIFDFEVADISLDGYNPDPAIKAPISV 314
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>TYSY_LISMF (Q71YE1) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 314

 Score =  172 bits (437), Expect = 6e-43
 Identities = 82/159 (51%), Positives = 111/159 (69%)
 Frame = -2

Query: 564 GKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMALPPCHMFAQFYVENGELSCQMYQ 385
           G+  DQLAD+I  IK NP+ RR+I+SAWNP D+  MALPPCH   QFYV +G+LSCQ+YQ
Sbjct: 156 GETIDQLADLIEMIKTNPNSRRLIVSAWNPEDIPNMALPPCHSLFQFYVADGKLSCQLYQ 215

Query: 384 RSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHVIGDAHVYSTHVQALEEQLQKQPK 205
           RSAD+ LGVPFNIASY+LLT +IA+   L  GEF+H +GDAH+Y+ H++ ++EQL + P 
Sbjct: 216 RSADIFLGVPFNIASYALLTHLIAREVGLEVGEFIHTMGDAHLYNNHIEQVKEQLSRTPH 275

Query: 204 PFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKMAV 88
             P L ++     I  F  +D  L  Y+P   I+  ++V
Sbjct: 276 KLPKLVLSDKPATIFDFDVADISLDGYNPDPAIKAPISV 314
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>TYSY_RALSO (Q8Y0U6) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 264

 Score =  172 bits (437), Expect = 6e-43
 Identities = 87/182 (47%), Positives = 117/182 (64%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GP+Y +Q R +           +G+  DQ+A++I +IK NPD RR+I+SAWN  D+ +M 
Sbjct: 91  GPIYGYQWRSWPTP--------SGEHIDQIAELIAQIKRNPDSRRLIVSAWNVADIPRMK 142

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           LPPCH F QFYV +G+LSCQ+YQRSAD+ LGVPFNIASY+LLT MIAQ   L  G+FV  
Sbjct: 143 LPPCHAFFQFYVADGKLSCQLYQRSADIFLGVPFNIASYALLTHMIAQQTGLDVGDFVWT 202

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKM 94
            GD H+Y+ H + +E QL + P P P L I      I  +   DF++  Y+ H  I+  +
Sbjct: 203 GGDCHLYNNHFEQVETQLARTPLPLPKLHIKRKPDSIFDYRYEDFEIVGYESHPAIKAPV 262

Query: 93  AV 88
           AV
Sbjct: 263 AV 264
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>TYSY_MYCPN (P78029) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 287

 Score =  172 bits (436), Expect = 7e-43
 Identities = 87/182 (47%), Positives = 117/182 (64%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GPVY  Q R F              G DQL  VI +IK NP  RR+I+S+WNP ++ +M 
Sbjct: 120 GPVYGKQWRDFN-------------GVDQLKKVIAQIKVNPFSRRLIVSSWNPNEVDQML 166

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           LPPCH   QFYV++G+LSCQ+YQRS D+ LG+PFNIASYSLL  ++A+  +L PG FVH 
Sbjct: 167 LPPCHSLYQFYVQDGQLSCQLYQRSGDIFLGIPFNIASYSLLVYLVAKETNLKPGSFVHT 226

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKM 94
           IGDAH+Y  H++ ++ QL +QPKP P + +    K I  +   D +L  YD H  I+ ++
Sbjct: 227 IGDAHIYENHLEQIKLQLTRQPKPLPKVVLKS-DKSIFDYQFDDIELVDYDHHPTIKGEV 285

Query: 93  AV 88
           AV
Sbjct: 286 AV 287
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>TYSY_PHOLL (Q7N8U4) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 264

 Score =  172 bits (435), Expect = 1e-42
 Identities = 88/182 (48%), Positives = 119/182 (65%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GPVY  Q R +G       AD  G+  DQL  V+ ++K++PD RRII+SAWN  +L KMA
Sbjct: 91  GPVYGKQWRAWGT------AD--GRQIDQLKTVLEQLKSDPDSRRIIVSAWNVGELDKMA 142

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           L PCH F QFYV +G+LSCQ+YQRS D+ LG+PFNIASY+LL  M+AQ CDL  G+FV  
Sbjct: 143 LAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWT 202

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKM 94
            GD H+YS H++  + QL ++P+  P L I      +  +   DF++  YDPH  I+  +
Sbjct: 203 GGDTHLYSNHMEQTKLQLSREPRSLPKLVIKRKPASLFDYKFDDFEIVDYDPHPGIKAPV 262

Query: 93  AV 88
           A+
Sbjct: 263 AI 264
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>TYSY_ERWCT (Q6D8I6) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 264

 Score =  171 bits (434), Expect = 1e-42
 Identities = 87/182 (47%), Positives = 119/182 (65%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GPVY  Q R +GA      AD  G+  DQL +V+ +++ +PD RRII+SAWN  +L KMA
Sbjct: 91  GPVYGKQWRSWGA------AD--GRQIDQLKNVLTQLRQDPDSRRIIVSAWNVGELDKMA 142

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           L PCH F QFYV +G+LSCQ+YQRS D+ LG+PFNIASY+LL  M+AQ CDL  G+FV  
Sbjct: 143 LAPCHAFFQFYVADGKLSCQLYQRSCDIFLGLPFNIASYALLVHMVAQQCDLDVGDFVWT 202

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKM 94
            GD H+Y+ H++    QL ++P+  P L I      +  +   DF++  YDPH  I+  +
Sbjct: 203 GGDTHLYNNHMEQTHLQLSREPRALPKLVIKRRPDTLFDYRFEDFEIEGYDPHPAIKAPV 262

Query: 93  AV 88
           A+
Sbjct: 263 AI 264
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>TYSY_SALTY (Q8ZMA9) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 264

 Score =  171 bits (432), Expect = 2e-42
 Identities = 86/182 (47%), Positives = 117/182 (64%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GPVY  Q R +            G+  DQ+A V++++KN+PD RRII+SAWN  +L KMA
Sbjct: 91  GPVYGKQWRAWPTP--------DGRHIDQIATVLSQLKNDPDSRRIIVSAWNVGELDKMA 142

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           L PCH F QFYV +G+LSCQ+YQRS D+ LG+PFNIASY+LL  M+AQ CDL  G+FV  
Sbjct: 143 LAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLDVGDFVWT 202

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKM 94
            GD H+YS H++    QL ++P+  P L I      +  +   DF++  YDPH  I+  +
Sbjct: 203 GGDTHLYSNHMEQTHLQLSREPRALPKLVIKRKPDSLFDYRFDDFEIEGYDPHPGIKAPV 262

Query: 93  AV 88
           A+
Sbjct: 263 AI 264
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>TYSY_SALTI (Q8Z412) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 264

 Score =  171 bits (432), Expect = 2e-42
 Identities = 86/182 (47%), Positives = 117/182 (64%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GPVY  Q R +            G+  DQ+A V++++KN+PD RRII+SAWN  +L KMA
Sbjct: 91  GPVYGKQWRAWPTP--------DGRHIDQIATVLSQLKNDPDSRRIIVSAWNVGELDKMA 142

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           L PCH F QFYV +G+LSCQ+YQRS D+ LG+PFNIASY+LL  M+AQ CDL  G+FV  
Sbjct: 143 LAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLDVGDFVWT 202

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKM 94
            GD H+YS H++    QL ++P+  P L I      +  +   DF++  YDPH  I+  +
Sbjct: 203 GGDTHLYSNHMEQTHLQLSREPRALPKLVIKRKPDSLFDYRFDDFEIEGYDPHPGIKAPV 262

Query: 93  AV 88
           A+
Sbjct: 263 AI 264
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>TYSY_SALPA (Q5PEN6) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 264

 Score =  171 bits (432), Expect = 2e-42
 Identities = 86/182 (47%), Positives = 117/182 (64%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GPVY  Q R +            G+  DQ+A V++++KN+PD RRII+SAWN  +L KMA
Sbjct: 91  GPVYGKQWRAWPTP--------DGRHIDQIATVLSQLKNDPDSRRIIVSAWNVGELDKMA 142

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           L PCH F QFYV +G+LSCQ+YQRS D+ LG+PFNIASY+LL  M+AQ CDL  G+FV  
Sbjct: 143 LAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLDVGDFVWT 202

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKM 94
            GD H+YS H++    QL ++P+  P L I      +  +   DF++  YDPH  I+  +
Sbjct: 203 GGDTHLYSNHMEQTHLQLSREPRALPKLVIKRKPDSLFDYRFDDFEIEGYDPHPGIKAPV 262

Query: 93  AV 88
           A+
Sbjct: 263 AI 264
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>TYSY_LEGPL (Q5WSU5) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 264

 Score =  169 bits (429), Expect = 5e-42
 Identities = 89/182 (48%), Positives = 114/182 (62%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GPVY  Q R +        AD  G   DQL+DV+ +IK+NPD RR+I+SAWN  +L KMA
Sbjct: 91  GPVYGKQWRSWPT------AD--GGTIDQLSDVVQQIKSNPDSRRLIVSAWNVGELDKMA 142

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           L PCH   QFYV N +LSCQ+YQRSAD+ LGVPFNIASYSLLT M+AQ C+L   EF+  
Sbjct: 143 LMPCHALFQFYVANNKLSCQLYQRSADVFLGVPFNIASYSLLTHMVAQQCNLDVAEFIWT 202

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKM 94
            GD H+Y  H++  + QL ++P P P L I      +  +   DF+   Y  H  I+  +
Sbjct: 203 GGDCHLYLNHLEQAQTQLTREPLPLPSLAIKRKPASLFDYAYEDFEFVNYQSHPAIKAPI 262

Query: 93  AV 88
           AV
Sbjct: 263 AV 264
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>TYSY_MYCPE (Q8EV81) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 289

 Score =  169 bits (429), Expect = 5e-42
 Identities = 88/183 (48%), Positives = 118/183 (64%), Gaps = 1/183 (0%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GPVY  Q R+F              G DQ+ ++I +IK N   RR+I+S WNP+++K M 
Sbjct: 120 GPVYGRQWRNFN-------------GVDQITNLIEEIKKNKYSRRLIVSVWNPSEIKNML 166

Query: 453 LPPCHMFAQFYVEN-GELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVH 277
           LPPCH   QF+V +  ELSCQ+YQRSAD+ LGVPFNIASYSLLT MIAQV + +  EFVH
Sbjct: 167 LPPCHCLFQFFVNSKNELSCQLYQRSADLFLGVPFNIASYSLLTYMIAQVTNTTAKEFVH 226

Query: 276 VIGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMK 97
            IG AH+Y+ H+  ++EQL ++P   P L +N   K+I  F   D ++  Y+ H  I+ K
Sbjct: 227 TIGVAHIYNNHIDQVKEQLTREPLQLPTLVLNKNIKNIFDFKIEDIEIKDYNSHPAIKGK 286

Query: 96  MAV 88
           +AV
Sbjct: 287 VAV 289
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>TYSY_LEIXX (Q6AFI0) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 269

 Score =  169 bits (427), Expect = 8e-42
 Identities = 86/182 (47%), Positives = 111/182 (60%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GPVY  Q R + +          G   DQ+  V++ ++ +PD RRII+SAWN  D+  MA
Sbjct: 96  GPVYGVQWRSWPSP--------DGTHIDQIQQVVDTLRRDPDSRRIIVSAWNVADIPDMA 147

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           L PCH F QFYV +G+LSCQ+YQRSADM LGVPFNIASY+LLT M+AQ   L PGEFV  
Sbjct: 148 LAPCHAFFQFYVADGKLSCQLYQRSADMFLGVPFNIASYALLTLMVAQQVGLEPGEFVWT 207

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKM 94
            GD H+Y  H++ + EQL + P P P L+     + +  +   DF L  Y  H  I   +
Sbjct: 208 GGDVHIYDNHIEQVNEQLSRNPFPAPALRFARRPESVFDYRYEDFVLEGYRHHPAIRAAV 267

Query: 93  AV 88
           AV
Sbjct: 268 AV 269
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>TYSY_LEGPA (Q5X119) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 264

 Score =  169 bits (427), Expect = 8e-42
 Identities = 89/182 (48%), Positives = 114/182 (62%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GPVY  Q R +        AD  G   DQL+DV+ +IK+NPD RR+I+SAWN  +L KMA
Sbjct: 91  GPVYGKQWRSWPT------AD--GHTIDQLSDVVQQIKSNPDSRRLIVSAWNVGELDKMA 142

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           L PCH   QFYV N +LSCQ+YQRSAD+ LGVPFNIASYSLLT M+AQ C+L   EF+  
Sbjct: 143 LMPCHALFQFYVANNKLSCQLYQRSADVFLGVPFNIASYSLLTHMVAQQCNLDVAEFIWT 202

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKM 94
            GD H+Y  H++  + QL ++P P P L I      +  +   DF+   Y  H  I+  +
Sbjct: 203 GGDCHLYLNHLEQAQIQLTREPLPLPSLTIKRKPASLFDYAYEDFEFLNYQSHPAIKAPI 262

Query: 93  AV 88
           AV
Sbjct: 263 AV 264
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>TYSY_LEGPH (Q5ZRL3) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 264

 Score =  168 bits (426), Expect = 1e-41
 Identities = 88/182 (48%), Positives = 115/182 (63%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GPVY  Q R +        AD  G+  DQL++V+ +IK+NPD RR+I+SAWN  +L KMA
Sbjct: 91  GPVYGKQWRSWPT------AD--GRTIDQLSEVVQQIKSNPDSRRLIVSAWNVGELDKMA 142

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           L PCH   QFYV N +LSCQ+YQRSAD+ LGVPFNIASYSLLT M+AQ C+L   EF+  
Sbjct: 143 LMPCHALFQFYVANNKLSCQLYQRSADVFLGVPFNIASYSLLTHMVAQQCNLDVAEFIWT 202

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKM 94
            GD H+Y  H++  + QL ++P P P L I      +  +   DF+   Y  H  I+  +
Sbjct: 203 GGDCHLYLNHLEQAQIQLTREPLPLPSLAIKRKPASLFDYAYEDFEFLNYQSHPAIKAPI 262

Query: 93  AV 88
           AV
Sbjct: 263 AV 264
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>TYSY_CORDI (Q6NIF2) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 270

 Score =  168 bits (426), Expect = 1e-41
 Identities = 87/182 (47%), Positives = 112/182 (61%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GPVY  Q R +            G+  DQ+A  ++ +KNNPD RR I+SAWN  DL  MA
Sbjct: 98  GPVYGVQWRSWPTP--------DGQHVDQIAQALDILKNNPDSRRNIVSAWNVADLNNMA 149

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           LPPCH+  Q YV +G+LSCQ+YQRSADM LGVPFNIASYS LT M+AQ   L  GEF+  
Sbjct: 150 LPPCHLLFQLYVADGKLSCQLYQRSADMFLGVPFNIASYSALTHMLAQQAGLKVGEFIWT 209

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKM 94
            GD H+Y  H + +  QL ++P+P+P L +       D +   DF +  YDPH  I  ++
Sbjct: 210 GGDCHIYDNHREQVLTQLSREPRPYPQLTLRKASSIFD-YDFDDFTIEGYDPHPAIRGEV 268

Query: 93  AV 88
           AV
Sbjct: 269 AV 270
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>TYSY_CORGL (Q8NS38) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 266

 Score =  168 bits (425), Expect = 1e-41
 Identities = 84/182 (46%), Positives = 115/182 (63%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GPVY  Q R +            G+  DQ++  +  ++NNPD RR I+SAWN ++L+ MA
Sbjct: 94  GPVYGVQWRSWPTP--------DGRHIDQISGALETLRNNPDSRRNIVSAWNVSELENMA 145

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           LPPCH+  Q YV +G+LSCQ+YQRSADM LGVPFNIASY+LLT M AQ   L  GEF+  
Sbjct: 146 LPPCHLLFQLYVADGKLSCQLYQRSADMFLGVPFNIASYALLTHMFAQQAGLEVGEFIWT 205

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKM 94
            GD H+Y  H + + EQL ++ +P+P L++N      + +   D  ++ YDPH  I  K+
Sbjct: 206 GGDCHIYDNHKEQVAEQLSREARPYPTLELNKAASMFE-YSFDDITVSGYDPHPLIRGKV 264

Query: 93  AV 88
           AV
Sbjct: 265 AV 266
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>TYSY_PROAC (Q6A761) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 269

 Score =  167 bits (424), Expect = 2e-41
 Identities = 88/188 (46%), Positives = 117/188 (62%), Gaps = 6/188 (3%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GPVY  Q R +  +   +         DQ+A+V+ +I+ NP  RR I+SAWN  ++K+MA
Sbjct: 91  GPVYGHQWRSWPDDDGTI---------DQIANVVEQIRTNPWSRRHIVSAWNVAEIKEMA 141

Query: 453 LPPCHMFAQFYVENGE------LSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSP 292
           LPPCH   QFYV   +      LSCQ+YQRS D  LGVPFNIASY+LLT ++A V  L P
Sbjct: 142 LPPCHTLFQFYVTPDDRGTPTWLSCQLYQRSGDTFLGVPFNIASYALLTHLVASVTGLKP 201

Query: 291 GEFVHVIGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQ 112
             FVH +GDAHVY  H+  + EQL+++P+  P L +NP  +DID F  SD  L  YDP+ 
Sbjct: 202 LRFVHTLGDAHVYLNHLDQVHEQLKRKPRHRPTLTVNPGIRDIDGFELSDITLTGYDPYP 261

Query: 111 KIEMKMAV 88
            +   +AV
Sbjct: 262 ALPAPIAV 269
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>TYSY_NOCFA (Q5YPL7) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 266

 Score =  167 bits (423), Expect = 2e-41
 Identities = 85/182 (46%), Positives = 115/182 (63%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GPVY  Q R +            G   DQ++ V+  ++ +PD RR+I+SAWN  +L +MA
Sbjct: 94  GPVYGVQWRSWPTP--------DGTHIDQISQVLQTLRTDPDSRRMIVSAWNVAELDRMA 145

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           L PCH F QFYV +G+LSCQ+YQRSAD+ LGVPFNIASY+LLT M+AQ  +L PGEF+  
Sbjct: 146 LAPCHAFFQFYVADGKLSCQLYQRSADLFLGVPFNIASYALLTHMVAQQTELEPGEFIWT 205

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKM 94
            GD H+Y  HV+ + EQL ++P PFP L++ P     D +   D  +  Y  H  I+  +
Sbjct: 206 GGDCHIYDNHVEQVTEQLGREPYPFPRLELRPAPSLFD-YRFEDVTVTDYRHHPAIKAPV 264

Query: 93  AV 88
           AV
Sbjct: 265 AV 266
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>TYSY_MYCTU (P67044) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 263

 Score =  166 bits (421), Expect = 4e-41
 Identities = 83/182 (45%), Positives = 118/182 (64%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GP+Y  Q R + A         +G+  DQ++  ++ ++ +PD RRII+SAWN  ++++MA
Sbjct: 91  GPIYGVQWRSWPAP--------SGEHIDQISAALDLLRTDPDSRRIIVSAWNVGEIERMA 142

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           LPPCH F QFYV +G LSCQ+YQRSAD+ LGVPFNIASY+LLT M+A    LS GEF+  
Sbjct: 143 LPPCHAFFQFYVADGRLSCQLYQRSADLFLGVPFNIASYALLTHMMAAQAGLSVGEFIWT 202

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKM 94
            GD H+Y  HV+ +  QL ++P+P+P L +   +  I  +   D  +  YDPH  I+  +
Sbjct: 203 GGDCHIYDNHVEQVRLQLSREPRPYPKLLLAD-RDSIFEYTYEDIVVKNYDPHPAIKAPV 261

Query: 93  AV 88
           AV
Sbjct: 262 AV 263
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>TYSY_MYCBO (P67045) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 263

 Score =  166 bits (421), Expect = 4e-41
 Identities = 83/182 (45%), Positives = 118/182 (64%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GP+Y  Q R + A         +G+  DQ++  ++ ++ +PD RRII+SAWN  ++++MA
Sbjct: 91  GPIYGVQWRSWPAP--------SGEHIDQISAALDLLRTDPDSRRIIVSAWNVGEIERMA 142

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           LPPCH F QFYV +G LSCQ+YQRSAD+ LGVPFNIASY+LLT M+A    LS GEF+  
Sbjct: 143 LPPCHAFFQFYVADGRLSCQLYQRSADLFLGVPFNIASYALLTHMMAAQAGLSVGEFIWT 202

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKM 94
            GD H+Y  HV+ +  QL ++P+P+P L +   +  I  +   D  +  YDPH  I+  +
Sbjct: 203 GGDCHIYDNHVEQVRLQLSREPRPYPKLLLAD-RDSIFEYTYEDIVVKNYDPHPAIKAPV 261

Query: 93  AV 88
           AV
Sbjct: 262 AV 263
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>TYSY_XENNE (Q6REU8) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 264

 Score =  166 bits (421), Expect = 4e-41
 Identities = 85/182 (46%), Positives = 118/182 (64%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GPVY  Q R +G+      AD  G+  DQL  V+ ++K +PD RRII+SAWN  +L KMA
Sbjct: 91  GPVYGKQWRAWGS------AD--GRHIDQLTQVLEQLKGDPDSRRIIVSAWNVGELDKMA 142

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           L PCH F QFYV +G+LSCQ+YQRS D+ LG+PFNIASY+LL  M+AQ C+L  G+FV  
Sbjct: 143 LAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCNLDVGDFVWT 202

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKM 94
            GD H+Y+ H++    QL ++P+  P L I      +  +   DF++  YDP+  I+  +
Sbjct: 203 GGDTHLYNNHLEQTHLQLSREPRALPKLVIKRKPDSLFDYRFEDFEIVDYDPYPGIKAPV 262

Query: 93  AV 88
           A+
Sbjct: 263 AI 264
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>TYSY_FRATT (Q5NFK5) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 274

 Score =  165 bits (417), Expect = 1e-40
 Identities = 84/184 (45%), Positives = 110/184 (59%), Gaps = 13/184 (7%)
 Frame = -2

Query: 600 GAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKK------------- 460
           G  Y     D+ G+G DQ+ADVI  +K NP+ RRI++SAWNP  +               
Sbjct: 91  GPIYGKQWRDFNGQGIDQIADVIQMLKTNPNSRRILVSAWNPCVVPSEKISPQENVVKGN 150

Query: 459 MALPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFV 280
            ALPPCH   QFYV N +LSC + QRSAD  LGVPFNIASYSLLT M+AQ C+L  GEF+
Sbjct: 151 SALPPCHAMFQFYVANNKLSCMLTQRSADAFLGVPFNIASYSLLTNMVAQQCNLDVGEFI 210

Query: 279 HVIGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEM 100
              GD H+Y+ H++ + EQL ++P   P LKI      I  +   DF+   Y+ H  I+ 
Sbjct: 211 WSGGDCHIYNNHIEQVNEQLSREPLALPTLKILRKPNSIFDYKYEDFEFENYNHHPAIKA 270

Query: 99  KMAV 88
           K++V
Sbjct: 271 KISV 274
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>TYSY_GEOKA (Q5KZ25) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 264

 Score =  165 bits (417), Expect = 1e-40
 Identities = 85/183 (46%), Positives = 113/183 (61%), Gaps = 1/183 (0%)
 Frame = -2

Query: 633 GPVYXFQXRHF-GAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKM 457
           GP+Y  Q R + GA+         GK  DQ+A V+ +IK NP+ RR+++SAWN  +L +M
Sbjct: 91  GPIYGAQWRSWKGAD---------GKTIDQIAWVVEEIKRNPNSRRLLVSAWNVAELDEM 141

Query: 456 ALPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVH 277
            LPPCH   QFYV NG LSC   QRS D  LG+PFNIASY+LLT MIAQ CDL  GE + 
Sbjct: 142 KLPPCHYAFQFYVANGRLSCMWQQRSVDTFLGLPFNIASYALLTHMIAQQCDLDVGELIF 201

Query: 276 VIGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMK 97
             GD H+Y  H++  + QL ++P+P P L I      I  +   DF++  Y+PH  I+  
Sbjct: 202 TGGDVHLYKNHLEQAKLQLTREPRPLPKLVIKRKPPSIFDYEYDDFEIVGYNPHPTIKAP 261

Query: 96  MAV 88
           +AV
Sbjct: 262 VAV 264
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>TYSY_COXBU (Q83BG2) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 264

 Score =  164 bits (415), Expect = 2e-40
 Identities = 84/182 (46%), Positives = 114/182 (62%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GP+Y  Q R +            G+  DQ+  +I +IK NPD RR+I+SAWN  +L +MA
Sbjct: 91  GPIYGKQWRRWHCP--------DGRTVDQMQRLIREIKTNPDSRRLIVSAWNVGELDQMA 142

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           LPPCH+  QFYV +G LSC++ QRSAD  LGVPFNIASYSLLT +IA+ C+L  GEF+  
Sbjct: 143 LPPCHLLFQFYVADGFLSCKLTQRSADAFLGVPFNIASYSLLTHLIARQCNLKAGEFIWS 202

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKM 94
            GD H+Y+TH   +  QL ++P+  P L IN     +  +  +DF +  Y PH  I+  +
Sbjct: 203 GGDCHIYNTHQDQVSTQLSREPRALPQLIINRDPSSLYDYNFNDFSIVNYHPHPAIKAPV 262

Query: 93  AV 88
           AV
Sbjct: 263 AV 264
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>TYSY_LACJO (Q74IU3) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 318

 Score =  164 bits (415), Expect = 2e-40
 Identities = 85/182 (46%), Positives = 111/182 (60%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           G VY  Q RH+            G   DQ+ +VI++IK  P  RR+I+SAWNP D+   A
Sbjct: 145 GDVYGAQWRHWQKR--------EGGFIDQIQNVIDQIKKTPYSRRLIVSAWNPEDVPTSA 196

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           LPPCH+  QFYV +G LS Q+YQRS DM LGVPFNIASY+LL  ++A+   L PGEF+H 
Sbjct: 197 LPPCHVLFQFYVNDGCLSLQLYQRSGDMFLGVPFNIASYALLVNLVARETGLKPGEFIHT 256

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKM 94
           +GDAH+Y  H   ++E L +     P+L +NP KK +  F   D KL  Y  H  I+  +
Sbjct: 257 LGDAHIYKNHFNQVKELLNRSAYDAPMLWLNPDKKLVQDFEMKDIKLINYRHHGTIKAPV 316

Query: 93  AV 88
           AV
Sbjct: 317 AV 318
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>TYSY_MYCPA (Q73VZ2) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 266

 Score =  164 bits (414), Expect = 3e-40
 Identities = 84/182 (46%), Positives = 116/182 (63%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GP+Y  Q R +           +G+  DQ++  ++ ++ +PD RRII+SAWN  ++ +MA
Sbjct: 94  GPIYGVQWRSWPTP--------SGEHIDQISAALDLLRTDPDSRRIIVSAWNVGEIPRMA 145

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           LPPCH F QFYV +G LSCQ+YQRSAD+ LGVPFNIASY+LLT M+A    LS GEFV  
Sbjct: 146 LPPCHAFFQFYVADGRLSCQLYQRSADLFLGVPFNIASYALLTHMMAAQAGLSVGEFVWT 205

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKM 94
            GD H+Y  HV+ +  QL ++P+P+P L I   +  I  +   D  +  YDPH  I+  +
Sbjct: 206 GGDCHIYDNHVEQVRLQLSREPRPYPEL-ILAHRDSIFDYTYDDVVVHNYDPHPAIKAPV 264

Query: 93  AV 88
           AV
Sbjct: 265 AV 266
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>TYSY_MYCPU (Q98Q31) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 286

 Score =  161 bits (407), Expect = 2e-39
 Identities = 85/182 (46%), Positives = 115/182 (63%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GPVY  Q R F              G DQL  VI +IKNNP+ RR+I+S+WNP+++  M 
Sbjct: 120 GPVYGKQWRDF-------------LGIDQLKKVIEQIKNNPNSRRLIVSSWNPSEIDTML 166

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           LPPCH   QFYV + +LSC +YQRSAD  LG+PFNIASY+LLT ++AQ  +L  G+FVH 
Sbjct: 167 LPPCHTLFQFYVNDNKLSCHLYQRSADAFLGIPFNIASYALLTFLLAQETNLEVGDFVHS 226

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKM 94
           IGDAH+Y  H++ ++ QL++ PK  P L I    K+I      D +L  Y+    I+ ++
Sbjct: 227 IGDAHIYVNHLEQVKTQLKRNPKELPKLIIK--NKNIFEINFEDIELVDYEFDPIIKGEV 284

Query: 93  AV 88
           AV
Sbjct: 285 AV 286
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>TYSY_MYCLE (Q9CBW0) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 266

 Score =  160 bits (404), Expect = 4e-39
 Identities = 82/182 (45%), Positives = 112/182 (61%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GP+Y  Q R +     D          DQ++  ++ ++  PD RRII+SAWN  ++ +MA
Sbjct: 94  GPIYGVQWRSWPTSSGDY--------IDQISTALDLLRTEPDSRRIIVSAWNVGEIPQMA 145

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           LPPCH F QFYV  G LSCQ+YQRSADM LGVPFNIASY+LLT M+A    L  GEFV  
Sbjct: 146 LPPCHAFFQFYVAQGRLSCQLYQRSADMFLGVPFNIASYALLTHMMAAQSGLLVGEFVWT 205

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKM 94
            GD H+Y  HV+ ++ QL ++P+ +P L +   +  I  +V  D  +  YDPH  I+  +
Sbjct: 206 GGDCHIYDNHVEQVQLQLSREPRAYPELFL-AQRDSIFDYVYEDVVVTNYDPHPAIKAPV 264

Query: 93  AV 88
           A+
Sbjct: 265 AI 266
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>TYSY_MESFL (Q6F145) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 288

 Score =  159 bits (402), Expect = 7e-39
 Identities = 87/183 (47%), Positives = 113/183 (61%), Gaps = 1/183 (0%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GPVY  Q R FG             G DQ A +IN IK NP  RR I+SAWNP ++  M 
Sbjct: 120 GPVYGKQWRDFG-------------GIDQFAKLINDIKKNPFSRRHIVSAWNPAEVDNML 166

Query: 453 LPPCHMFAQFYV-ENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVH 277
           LPPCH F Q YV ++G L  Q+YQRS D+ LGVPFNIASY+LL  +IA+ C+L    FVH
Sbjct: 167 LPPCHSFWQVYVSKDGWLDLQLYQRSGDVFLGVPFNIASYALLMELIAKECNLKARYFVH 226

Query: 276 VIGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMK 97
            IGDAH+Y  H++ + EQL+++P P   +KIN  +K I      D ++  Y+ H KI  +
Sbjct: 227 TIGDAHIYLNHLEQINEQLKRKPLPLCKIKINS-EKSIFDIAFEDIEIEGYESHAKITGE 285

Query: 96  MAV 88
           +AV
Sbjct: 286 VAV 288
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>TYSY_BUCBP (P59427) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 264

 Score =  159 bits (401), Expect = 9e-39
 Identities = 82/182 (45%), Positives = 114/182 (62%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GP+Y  Q R +  +         G+  DQ+ +VI+ IKNNP+ RRI++S+WN  DL KMA
Sbjct: 91  GPIYGEQWRSWKTK--------DGRVIDQIDNVIHLIKNNPNSRRIVVSSWNVGDLHKMA 142

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           L PCH+  QF+V +  L CQ+YQRS D+ LG+PFNIASYSLLT MIAQ C+L  G F+  
Sbjct: 143 LLPCHVLFQFHVVDHVLHCQLYQRSCDVFLGLPFNIASYSLLTHMIAQQCNLKVGNFIWT 202

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKM 94
            GD H+Y  H++  ++Q+ ++P   P L IN     I +++  DF L  Y  H  I  K+
Sbjct: 203 GGDVHLYKNHIKQAKKQILRRPYLLPKLVINRKPTQIFNYLLQDFNLLNYKYHPSIHAKI 262

Query: 93  AV 88
           A+
Sbjct: 263 AI 264
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>TYSY_BUCAI (P57515) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 264

 Score =  158 bits (400), Expect = 1e-38
 Identities = 76/182 (41%), Positives = 115/182 (63%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GP+Y  Q R++            G   DQ+ +V+ ++K NPD RR+++S+WN  D+ KM 
Sbjct: 91  GPIYGKQWRNWSTP--------EGHEIDQIKNVLIQLKKNPDSRRMLVSSWNVGDIDKMR 142

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           LPPCH+  QFYV N  LSCQ+YQRS D+ LG+PFNIASYS+L  MIAQ CDL  G+F+  
Sbjct: 143 LPPCHVLFQFYVFNNTLSCQLYQRSCDVFLGLPFNIASYSILIHMIAQQCDLKVGDFLWT 202

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKM 94
            GD H+Y+ H++  ++Q+ + P+  P L I    + +  +   DFK+  Y P+  I+ ++
Sbjct: 203 GGDVHLYNNHIELAKKQILRIPRTLPKLTILKKPQSLFQYCFEDFKIIGYHPYPAIKGEI 262

Query: 93  AV 88
           ++
Sbjct: 263 SI 264
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>TYSY_BUCAP (Q8K9C3) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 264

 Score =  155 bits (393), Expect = 7e-38
 Identities = 78/182 (42%), Positives = 114/182 (62%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GP+Y  Q R +            GK  DQ+ +V+ +IK +PD RRI++S+WN  ++ KM+
Sbjct: 91  GPIYGKQWRSWDTS--------NGKKIDQIKNVLKQIKEDPDSRRILVSSWNVGEIDKMS 142

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           L PCH+  QFYV   +LSCQ+YQRS D+ LG+PFNIASY++L  MIAQ C+L  GEF+  
Sbjct: 143 LAPCHILFQFYVLKKKLSCQLYQRSCDVFLGLPFNIASYAILIHMIAQQCNLQVGEFLWT 202

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKM 94
            GD H+Y  HV+  ++Q+ + PK  P L I    + +  +   DFK+  Y P+  I+ K+
Sbjct: 203 GGDVHLYKNHVELAKKQILRIPKKLPELIILKKPQSLFQYSFEDFKIVGYKPYSLIKGKI 262

Query: 93  AV 88
           +V
Sbjct: 263 SV 264
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>TYSY_MYCGE (P47469) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 287

 Score =  154 bits (389), Expect = 2e-37
 Identities = 83/184 (45%), Positives = 114/184 (61%), Gaps = 2/184 (1%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GPVY  Q R+F              G DQL  VI +IK NP+ RR+I+S+WNP++L+KMA
Sbjct: 120 GPVYGKQWRNFN-------------GVDQLKKVIQEIKENPNSRRLIVSSWNPSELEKMA 166

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           L PCH   QFYVE  +LS Q+YQRS D+ LGVPFNIASY+LL  ++A    L PG F+H 
Sbjct: 167 LAPCHSLFQFYVEEDKLSLQLYQRSGDIFLGVPFNIASYALLVYLVAHETKLKPGYFIHT 226

Query: 273 IGDAHVYSTHVQALEEQLQKQ--PKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEM 100
           +GDAH+Y  H++ ++ QL +     P  +LK +   K I ++   D +L  Y+ H  I  
Sbjct: 227 LGDAHIYENHIEQIKLQLTRTTLDPPQVVLKSD---KSIFAYSFDDIELVGYNYHPFIYG 283

Query: 99  KMAV 88
           ++AV
Sbjct: 284 RVAV 287
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>TYSY_BPT4 (P00471) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 286

 Score =  151 bits (381), Expect = 2e-36
 Identities = 85/194 (43%), Positives = 113/194 (58%), Gaps = 12/194 (6%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GP+Y  Q R FG             G DQ+ +VI++IK  P+DRR I+SAWNP +LK MA
Sbjct: 106 GPIYGKQWRDFG-------------GVDQIIEVIDRIKKLPNDRRQIVSAWNPAELKYMA 152

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           LPPCHMF QF V NG L  Q YQRS D+ LG+PFNIASY+ L  ++A++C+L PG+ +  
Sbjct: 153 LPPCHMFYQFNVRNGYLDLQWYQRSVDVFLGLPFNIASYATLVHIVAKMCNLIPGDLIFS 212

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPLK------------KDIDSFVASDFKLA 130
            G+ H+Y  HV+  +E L+++PK    L I+ L             K +      DF L 
Sbjct: 213 GGNTHIYMNHVEQCKEILRREPKELCELVISGLPYKFRYLSTKEQLKYVLKLRPKDFVLN 272

Query: 129 CYDPHQKIEMKMAV 88
            Y  H  I+ KMAV
Sbjct: 273 NYVSHPPIKGKMAV 286
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>DRTS_MIMIV (Q5UQG3) Bifunctional dihydrofolate reductase-thymidylate synthase|
           (DHFR-TS) [Includes: Dihydrofolate reductase (EC
           1.5.1.3); Thymidylate synthase (EC 2.1.1.45)]
          Length = 563

 Score =  149 bits (375), Expect = 9e-36
 Identities = 82/192 (42%), Positives = 111/192 (57%), Gaps = 12/192 (6%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GP Y FQ R++GAEY+D    Y G+G DQL   I  I+NNP DRRI+++ WN +DL KMA
Sbjct: 372 GPGYGFQMRYWGAEYTDCKTSYQGQGIDQLNKCIESIQNNPHDRRIMINLWNCSDLDKMA 431

Query: 453 LPPCHMFAQFYVE----------NGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVC 304
           L PCH    F V+           G L+C + QRS D+ LG  +N  + +LLT +IA  C
Sbjct: 432 LAPCHFCYMFGVDLYEVPTTSGKKGRLNCHLVQRSWDVLLG--WNTTTAALLTYLIANHC 489

Query: 303 DLSPGEFVHVIGDAHVYSTHVQ--ALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLA 130
           DL PG  VH I DAH+Y +H+   A+ + LQ++ + FP L I   K+ ID +   D  + 
Sbjct: 490 DLDPGILVHSISDAHIYQSHIDSGAISQLLQRKCRKFPNLVIRNKKEKIDDYEFDDLIIE 549

Query: 129 CYDPHQKIEMKM 94
            Y P   I  +M
Sbjct: 550 NYYPCPSISAEM 561
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>TYSY_SYMTH (Q67JQ1) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 283

 Score =  144 bits (364), Expect = 2e-34
 Identities = 78/190 (41%), Positives = 115/190 (60%), Gaps = 9/190 (4%)
 Frame = -2

Query: 633 GPVYXFQXRHF-GAEYSDMHADYTGKGFDQLADVINKIKN--------NPDDRRIILSAW 481
           GP+Y  Q R + GA+         G+ +DQ+A VI +I+         +P+ RR+++S W
Sbjct: 102 GPIYGKQWRAWEGAD---------GRTYDQIAWVIQQIREIAADPERPHPNSRRLVVSPW 152

Query: 480 NPTDLKKMALPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCD 301
           N  DL++MALPPCH   QF+V++G L   ++QRSAD+ LGVPFNIASYSLL  M+AQV  
Sbjct: 153 NVADLEEMALPPCHGPFQFHVKDGRLHLAVWQRSADLFLGVPFNIASYSLLLHMVAQVTG 212

Query: 300 LSPGEFVHVIGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYD 121
           L+ G + H + D H+Y   +  +  QL ++P P P L +NP  ++ID F   D +L  Y 
Sbjct: 213 LAVGTYTHYLNDVHIYRNLLDQVRLQLTREPYPLPRLWLNPEVREIDQFTMDDIQLVDYK 272

Query: 120 PHQKIEMKMA 91
            H  I  +++
Sbjct: 273 HHPPIRGELS 282
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>TYSY_WIGBR (Q8D2N4) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 264

 Score =  142 bits (359), Expect = 6e-34
 Identities = 71/182 (39%), Positives = 106/182 (58%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GP+Y  Q R +         D      DQ+   +NK+K  P  RRI++S+WN  +L  M+
Sbjct: 91  GPIYGKQWRAW--------EDKKNNTIDQIEIALNKLKKEPSSRRILVSSWNVGELDLMS 142

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           +PPCH+  Q YV N +LSCQ+YQRS D+ LG+PFNI SY+LLT + A  CDL   + +  
Sbjct: 143 IPPCHVLFQLYVINNKLSCQVYQRSCDIFLGLPFNIGSYALLTHIFANQCDLLVEDLIWT 202

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKM 94
            GD H+Y  H+   + QL + P P P + I    K++ ++  +DF L  Y+ H KI+  +
Sbjct: 203 GGDIHLYKNHLNQAKLQLTRSPLPLPKIFIKKKPKNLFNYAFNDFLLIDYNHHPKIKAPI 262

Query: 93  AV 88
           ++
Sbjct: 263 SI 264
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>TYSY_ZYMMO (Q9Z671) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 296

 Score =  142 bits (357), Expect = 1e-33
 Identities = 73/183 (39%), Positives = 109/183 (59%), Gaps = 1/183 (0%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GPVY  Q R +  + SD      G+ +DQ+A +I  +K+NP  RR++   WN  +LK MA
Sbjct: 122 GPVYGRQWRRW--QGSD------GQVYDQIATLIETLKSNPSSRRMLFHGWNVAELKDMA 173

Query: 453 LPPCHMFAQFYV-ENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVH 277
           LPPCHM  Q++V  +G L+  +YQRSAD+ LG+PFN+   + L  M+A    L+ G+ V 
Sbjct: 174 LPPCHMVYQYHVTSDGRLNSLLYQRSADVFLGLPFNLVGAAALQAMLADQAGLALGDLVW 233

Query: 276 VIGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMK 97
             GD H+Y  H+  ++EQL ++P+ FP L++      I  +   DF +  YDPH  I+  
Sbjct: 234 TGGDVHIYRNHIDQMKEQLAREPRAFPRLELTRHPNSITDYKIEDFAITGYDPHPPIKGA 293

Query: 96  MAV 88
           +AV
Sbjct: 294 VAV 296
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>TYSY_CLOAB (Q97EV3) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 263

 Score =  141 bits (356), Expect = 1e-33
 Identities = 70/158 (44%), Positives = 103/158 (65%), Gaps = 2/158 (1%)
 Frame = -2

Query: 555 FDQLADVINKIKNNPDDRRIILSAWNPTDLKKMALPPCHMFAQFYVENGELSCQMYQRSA 376
           F Q+ ++I+ +K +P  RR+++S WN  DLK M+L PC     + V+NG+L+C + QRS 
Sbjct: 106 FKQIDNLIDTLKTDPQSRRMLISLWNIADLKDMSLTPCCYETLWDVQNGKLNCMLVQRSG 165

Query: 375 DMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHVIGDAHVYSTHVQALEEQLQKQPKPF- 199
           DM LGVPFN+  Y++L  +IAQV  L PG F HVI +AH+Y   ++ ++ QL+++ K + 
Sbjct: 166 DMPLGVPFNMCQYAVLVHLIAQVTGLKPGLFTHVINNAHIYKNQIEGMKIQLKRRDKAYE 225

Query: 198 -PILKINPLKKDIDSFVASDFKLACYDPHQKIEMKMAV 88
            P L INP  K+   F A D KL  Y  H KI+M++AV
Sbjct: 226 APKLWINPNIKNFYDFTADDIKLIDYKHHDKIKMEVAV 263
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>TYSY_METCA (Q603S2) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 260

 Score =  138 bits (348), Expect = 1e-32
 Identities = 73/182 (40%), Positives = 102/182 (56%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           GPVY  Q R++                DQLA ++ +++ NP  RR+++SAWNP+DL  MA
Sbjct: 91  GPVYGRQWRNWNG------------AIDQLAGLVEQLRRNPGSRRLLVSAWNPSDLDAMA 138

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           LPPCH   Q +V +G LS     RSAD+ LG+PFNIA Y+LLT M+AQ     PGE +  
Sbjct: 139 LPPCHYAFQCHVADGRLSLMFQMRSADVFLGLPFNIAGYALLTHMLAQQTGYEPGELIWC 198

Query: 273 IGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKM 94
            GD H+Y  H++    QL ++P P P LK+      +  +   DF +  Y  H  I+  +
Sbjct: 199 GGDVHLYLNHLEQARLQLTREPYPPPTLKLARKPGSLFDYRYEDFVVEDYQAHPHIKAAV 258

Query: 93  AV 88
           AV
Sbjct: 259 AV 260
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>TYSY_BPPHT (P07606) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 279

 Score =  133 bits (334), Expect = 5e-31
 Identities = 69/172 (40%), Positives = 100/172 (58%)
 Frame = -2

Query: 603 FGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMALPPCHMFAQF 424
           +G +    +    G+  DQ+  +++++KNNP  RR I   WNP DL  MAL PC    Q+
Sbjct: 108 YGFQLGKKNRSLNGEKVDQVDYLLHQLKNNPSSRRHITMLWNPDDLDAMALTPCVYETQW 167

Query: 423 YVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHVIGDAHVYSTH 244
           YV+ G+L  ++  RS DM LG PFN+  Y++L  MIAQV     GE++  IGD HVY+ H
Sbjct: 168 YVKQGKLHLEVRARSNDMALGNPFNVFQYNVLQRMIAQVTGYELGEYIFNIGDCHVYTRH 227

Query: 243 VQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKMAV 88
           +  L+ Q++++    P L INP  KD  +F   DFKL  Y    K+  ++AV
Sbjct: 228 IDNLKIQMEREQFEAPELWINPEVKDFYNFTVDDFKLINYKHGDKLLFEVAV 279
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>TYSY_BACNA (Q5D189) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 279

 Score =  132 bits (331), Expect = 1e-30
 Identities = 68/172 (39%), Positives = 101/172 (58%)
 Frame = -2

Query: 603 FGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMALPPCHMFAQF 424
           +G +    +    G+  DQ+  +++++KNNP  RR I   WNP DL  M+L PC    Q+
Sbjct: 108 YGFQLGKKNRSLNGEKVDQVDYLLHQLKNNPSSRRHITMLWNPDDLDAMSLTPCVYETQW 167

Query: 423 YVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHVIGDAHVYSTH 244
           YV++G+L  ++  RS DM LG PFN+  Y++L  MIAQV     GE++  IGD HVY+ H
Sbjct: 168 YVKHGKLHLEVRARSNDMALGNPFNVFQYNVLQRMIAQVTGYELGEYIFNIGDCHVYTRH 227

Query: 243 VQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKMAV 88
           +  L+ Q++++    P L INP  KD  +F   DFKL  Y    K+  ++AV
Sbjct: 228 IDNLKIQMEREQFEAPELWINPEVKDFYNFTIDDFKLINYKHGDKLLFEVAV 279
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>TYSY_BACMO (Q9ANR7) Thymidylate synthase A (EC 2.1.1.45) (TS A) (TSase A)|
          Length = 279

 Score =  132 bits (331), Expect = 1e-30
 Identities = 67/172 (38%), Positives = 101/172 (58%)
 Frame = -2

Query: 603 FGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMALPPCHMFAQF 424
           +G + +  + +  G+  DQ+  +++++KNNP  RR I   WNP +L  MAL PC    Q+
Sbjct: 108 YGFQLAKKNRNLNGEKVDQVDYLLHQLKNNPSSRRHITMLWNPDELDSMALTPCVYETQW 167

Query: 423 YVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHVIGDAHVYSTH 244
           YV+ G+L  ++  RS DM LG PFN+  Y++L  MIAQV     GE++  IGD HVY+ H
Sbjct: 168 YVKQGKLHLEVRARSNDMALGNPFNVFQYNVLQRMIAQVTGYELGEYIFNIGDCHVYTRH 227

Query: 243 VQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKMAV 88
           +  L+ Q++++    P L INP  KD   F   DFKL  Y    ++  ++AV
Sbjct: 228 IDNLKIQMEREQFEAPKLWINPEVKDFYDFTIDDFKLINYKHGDRLSFEVAV 279
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>TYSA_BACSU (P42326) Thymidylate synthase A (EC 2.1.1.45) (TS A) (TSase A)|
          Length = 279

 Score =  131 bits (329), Expect = 2e-30
 Identities = 68/172 (39%), Positives = 100/172 (58%)
 Frame = -2

Query: 603 FGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMALPPCHMFAQF 424
           +G +    +    G+  DQ+  +++++KNNP  RR I   WNP +L  MAL PC    Q+
Sbjct: 108 YGFQLGKKNRSLNGEKVDQVDYLLHQLKNNPSSRRHITMLWNPDELDAMALTPCVYETQW 167

Query: 423 YVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHVIGDAHVYSTH 244
           YV++G+L  ++  RS DM LG PFN+  Y++L  MIAQV     GE++  IGD HVY+ H
Sbjct: 168 YVKHGKLHLEVRARSNDMALGNPFNVFQYNVLQRMIAQVTGYELGEYIFNIGDCHVYTRH 227

Query: 243 VQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKMAV 88
           +  L+ Q++++    P L INP  KD   F   DFKL  Y    K+  ++AV
Sbjct: 228 IDNLKIQMEREQFEAPELWINPEVKDFYDFTIDDFKLINYKHGDKLLFEVAV 279
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>TYSA_BACAM (O30397) Thymidylate synthase A (EC 2.1.1.45) (TS A) (TSase A)|
           (Fragment)
          Length = 230

 Score =  129 bits (324), Expect = 7e-30
 Identities = 67/172 (38%), Positives = 99/172 (57%)
 Frame = -2

Query: 603 FGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMALPPCHMFAQF 424
           +G +    +    G+  DQ+  +++++KNNP  RR I   WNP +L  MAL PC    Q+
Sbjct: 59  YGFQLGKKNRSLNGEKVDQVDYLLHQLKNNPSSRRHITMLWNPDELDAMALTPCVYETQW 118

Query: 423 YVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHVIGDAHVYSTH 244
           YV++G+L  ++  RS DM LG PFN+  Y++L  MIAQV     GE++  IGD HVY+ H
Sbjct: 119 YVKHGKLHLEVRARSNDMALGNPFNVFQYNVLQRMIAQVTGYELGEYIFNIGDCHVYTRH 178

Query: 243 VQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKMAV 88
           +  L+ Q++++    P L INP  KD   F   DFKL  Y    K+  ++ V
Sbjct: 179 IDNLKIQMEREQFEAPELWINPEVKDFYDFTIDDFKLINYKHGDKLLFEVPV 230
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>TYSA_BACAT (O30394) Thymidylate synthase A (EC 2.1.1.45) (TS A) (TSase A)|
           (Fragment)
          Length = 227

 Score =  129 bits (324), Expect = 7e-30
 Identities = 67/172 (38%), Positives = 99/172 (57%)
 Frame = -2

Query: 603 FGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMALPPCHMFAQF 424
           +G +    +    G+  DQ+  +++++KNNP  RR I   WNP +L  MAL PC    Q+
Sbjct: 56  YGFQLGKKNRSLNGEKVDQVDYLLHQLKNNPSSRRHITMLWNPDELDAMALTPCVYETQW 115

Query: 423 YVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHVIGDAHVYSTH 244
           YV++G+L  ++  RS DM LG PFN+  Y++L  MIAQV     GE++  IGD HVY+ H
Sbjct: 116 YVKHGKLHLEVRARSNDMALGNPFNVFQYNVLQRMIAQVTGYELGEYIFNIGDCHVYTRH 175

Query: 243 VQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKMAV 88
           +  L+ Q++++    P L INP  KD   F   DFKL  Y    K+  ++ V
Sbjct: 176 IDNLKIQMEREQFEAPELWINPEVKDFYDFTIDDFKLINYKHGDKLLFEVRV 227
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>TYSY_BACLD (Q65J44) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 279

 Score =  128 bits (321), Expect = 2e-29
 Identities = 66/172 (38%), Positives = 99/172 (57%)
 Frame = -2

Query: 603 FGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMALPPCHMFAQF 424
           +G +    +    G+  DQ+  +++++K+NP  RR +   WNP DL  MAL PC    Q+
Sbjct: 108 YGYQLGKKNRTVNGQKVDQVDYLLHQLKHNPSSRRHLTMLWNPDDLDGMALTPCVYETQW 167

Query: 423 YVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHVIGDAHVYSTH 244
           YV+ G+LS ++  RS DM LG PFN+  Y++L  MIAQV     GE++  IGD H+Y+ H
Sbjct: 168 YVKEGKLSLEVRARSNDMALGNPFNVFQYNVLQRMIAQVLGYELGEYIFNIGDCHIYTRH 227

Query: 243 VQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKMAV 88
           +  L  Q++++    P L INP  K+   F   DFKL  Y    K+  ++AV
Sbjct: 228 IDNLNIQMKREQYEAPKLWINPDIKNFYDFTIDDFKLIDYKHGDKLTFEVAV 279
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>TYSA_BACLI (Q59212) Thymidylate synthase A (EC 2.1.1.45) (TS A) (TSase A)|
          Length = 279

 Score =  128 bits (321), Expect = 2e-29
 Identities = 66/172 (38%), Positives = 99/172 (57%)
 Frame = -2

Query: 603 FGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMALPPCHMFAQF 424
           +G +    +    G+  DQ+  +++++K+NP  RR +   WNP DL  MAL PC    Q+
Sbjct: 108 YGYQLGKKNRTVNGQKVDQVDYLLHQLKHNPSSRRHLTMLWNPDDLDGMALTPCVYETQW 167

Query: 423 YVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHVIGDAHVYSTH 244
           YV+ G+LS ++  RS DM LG PFN+  Y++L  MIAQV     GE++  IGD H+Y+ H
Sbjct: 168 YVKEGKLSLEVRARSNDMALGNPFNVFQYNVLQRMIAQVLGYELGEYIFNIGDCHIYTRH 227

Query: 243 VQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKMAV 88
           +  L  Q++++    P L INP  K+   F   DFKL  Y    K+  ++AV
Sbjct: 228 IDNLNIQMKREQYEAPKLWINPDIKNFYDFTIDDFKLIDYKHGDKLTFEVAV 279
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>TYSY_BORPE (Q7VUE3) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 323

 Score =  115 bits (288), Expect = 1e-25
 Identities = 74/221 (33%), Positives = 105/221 (47%), Gaps = 39/221 (17%)
 Frame = -2

Query: 633 GPVYXFQXRHF----------GAEYSDMHA---------DYTG-------KGFDQLADVI 532
           GPVY  Q RH+          G + +D  A         D  G       K  DQL   +
Sbjct: 103 GPVYGVQWRHWPAYKLLPSSAGGQVADALARGYRQVAEVDENGAPHVLLYKAVDQLRQCL 162

Query: 531 NKIKNNPDDRRIILSAWNPTDLKKMALPPCHMFAQFYVENG--ELSCQMYQRSADMGLGV 358
           + I+ +P DRRI+   WN   +++MALPPCH+  QF    G  E+S  +Y RS D+GLG 
Sbjct: 163 DTIRQSPGDRRILFHGWNWAQIEEMALPPCHLLYQFLPNAGTREISLCLYIRSNDVGLGT 222

Query: 357 PFNIASYSLLTCMIAQVCDLSPGEFVHVIGDAHVYSTHVQALEEQLQKQPKPFPILKINP 178
           PFN+   + L  ++ ++    P  F + IGDAHVY  H+  L EQL ++P P P L ++ 
Sbjct: 223 PFNLTEGAALLHLVGRLTGYKPRWFSYFIGDAHVYENHLPMLREQLAREPYPAPQLVLSD 282

Query: 177 LKKD-----------IDSFVASDFKLACYDPHQKIEMKMAV 88
              D           ++     DF L+ Y  H  +   MAV
Sbjct: 283 RIPDFAVTGKYEPQWLEQVEPGDFTLSGYQHHAPLTAPMAV 323
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>TYSY_PSEPK (Q88CN9) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 323

 Score =  114 bits (286), Expect = 2e-25
 Identities = 63/171 (36%), Positives = 91/171 (53%), Gaps = 13/171 (7%)
 Frame = -2

Query: 561 KGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMALPPCHMFAQFY--VENGELSCQMY 388
           K  DQ+   ++ I N+P  RRI+   WN   L +MALPPCH+  QF+  VE  E+S  +Y
Sbjct: 153 KAIDQVRQCLDTIANDPGSRRILFHGWNCAQLDEMALPPCHLLYQFHPNVETREISLTLY 212

Query: 387 QRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHVIGDAHVYSTHVQALEEQLQKQP 208
            RS D+GLG PFN+   + L  +  ++   +P  F + IGDAHVY  H+  L EQL+++P
Sbjct: 213 IRSNDLGLGTPFNLTEGAALLSLFGRLTGYTPRWFTYFIGDAHVYENHLDMLNEQLKREP 272

Query: 207 KPFPILKINPL-----------KKDIDSFVASDFKLACYDPHQKIEMKMAV 88
              P L I+              + ++    SDF L  Y+ H  +   MAV
Sbjct: 273 LEAPKLVISDRVPAFAETGKYEPEWLEKIEPSDFWLEGYEHHAPMTAPMAV 323
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>TYSY_PSESM (Q87UL4) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 323

 Score =  114 bits (284), Expect = 3e-25
 Identities = 62/171 (36%), Positives = 89/171 (52%), Gaps = 13/171 (7%)
 Frame = -2

Query: 561 KGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMALPPCHMFAQFYV--ENGELSCQMY 388
           K  DQ+   I+ I N+P  RRI+   WN   L +MALPPCH+  Q +   +  E+S  +Y
Sbjct: 153 KAIDQIRQCIDTIINDPGSRRILFHGWNCAQLDEMALPPCHLLYQLHPNPQTREISLTLY 212

Query: 387 QRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHVIGDAHVYSTHVQALEEQLQKQP 208
            RS D+GLG PFN+   + L  +I ++   +P  F + IGDAHVY  H+  L EQ+ ++P
Sbjct: 213 IRSNDLGLGTPFNLTEGAALLSLIGRLTGYTPRWFTYFIGDAHVYENHLDMLNEQMTREP 272

Query: 207 KPFPILKINPLKKD-----------IDSFVASDFKLACYDPHQKIEMKMAV 88
            P P L I+    +           ++    SDF L  Y  H  +   MAV
Sbjct: 273 YPMPKLVISDRVPEFAKTGVYQPEWLELIEPSDFSLEGYQHHPAMTAPMAV 323
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>TYSY_BORPA (Q7W1A9) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 323

 Score =  113 bits (283), Expect = 4e-25
 Identities = 72/221 (32%), Positives = 104/221 (47%), Gaps = 39/221 (17%)
 Frame = -2

Query: 633 GPVYXFQXRHFGA------EYSDMHADYTGKGFDQLADV--------------------I 532
           GPVY  Q RH+ A            AD   +G+ Q+A+V                    +
Sbjct: 103 GPVYGVQWRHWPAYKLLPRSAGGQVADALARGYRQVAEVAENGAPHVLLYKAVDQLRQCL 162

Query: 531 NKIKNNPDDRRIILSAWNPTDLKKMALPPCHMFAQFYVENG--ELSCQMYQRSADMGLGV 358
           + I  +P DRRI+   WN   +++MALPPCH+  QF    G  E+S  +Y RS D+GLG 
Sbjct: 163 DTIHQSPGDRRILFHGWNWAQIEEMALPPCHLLYQFLPNAGTREISLCLYIRSNDVGLGT 222

Query: 357 PFNIASYSLLTCMIAQVCDLSPGEFVHVIGDAHVYSTHVQALEEQLQKQPKPFPILKINP 178
           PFN+   + L  ++ ++    P  F + IGDAHVY  H+  L EQL ++P P P L ++ 
Sbjct: 223 PFNLTEGAALLHLVGRLTGYKPRWFSYFIGDAHVYENHLPMLREQLTREPYPAPQLVLSD 282

Query: 177 LKKD-----------IDSFVASDFKLACYDPHQKIEMKMAV 88
              D           ++     DF L+ Y  H  +   MAV
Sbjct: 283 RIPDFAVTGKYEPQWLEQVEPGDFTLSGYQHHAPLTAPMAV 323
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>TYSY_BORBR (Q7WP13) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 323

 Score =  113 bits (283), Expect = 4e-25
 Identities = 72/221 (32%), Positives = 104/221 (47%), Gaps = 39/221 (17%)
 Frame = -2

Query: 633 GPVYXFQXRHFGA------EYSDMHADYTGKGFDQLADV--------------------I 532
           GPVY  Q RH+ A            AD   +G+ Q+A+V                    +
Sbjct: 103 GPVYGVQWRHWPAYKLLPRSAGGQVADALARGYRQVAEVAENGAPHVLLYKAVDQLRQCL 162

Query: 531 NKIKNNPDDRRIILSAWNPTDLKKMALPPCHMFAQFYVENG--ELSCQMYQRSADMGLGV 358
           + I  +P DRRI+   WN   +++MALPPCH+  QF    G  E+S  +Y RS D+GLG 
Sbjct: 163 DTIHQSPGDRRILFHGWNWAQIEEMALPPCHLLYQFLPNAGTREISLCLYIRSNDVGLGT 222

Query: 357 PFNIASYSLLTCMIAQVCDLSPGEFVHVIGDAHVYSTHVQALEEQLQKQPKPFPILKINP 178
           PFN+   + L  ++ ++    P  F + IGDAHVY  H+  L EQL ++P P P L ++ 
Sbjct: 223 PFNLTEGAALLHLVGRLTGYKPRWFSYFIGDAHVYENHLPMLREQLTREPYPAPQLVLSD 282

Query: 177 LKKD-----------IDSFVASDFKLACYDPHQKIEMKMAV 88
              D           ++     DF L+ Y  H  +   MAV
Sbjct: 283 RIPDFAVTGKYEPQWLEQVEPGDFTLSGYQHHAPLTAPMAV 323
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>TYSY_FUSNN (Q8RGP6) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 275

 Score =  100 bits (248), Expect = 5e-21
 Identities = 59/179 (32%), Positives = 90/179 (50%)
 Frame = -2

Query: 624 YXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMALPP 445
           +  Q    G  Y    A  T     QL  VIN++K NP+ RRI+   W P +L +MAL P
Sbjct: 98  WKMQDGTIGKAYGYQIAQETFGQKSQLHYVINELKKNPNSRRIMTEIWIPNELSEMALTP 157

Query: 444 CHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHVIGD 265
           C    Q+ V   +L  ++ QRS D+ LG+  N+  YS+L  ++A  C L P E +  I +
Sbjct: 158 CVHLTQWSVIGNKLYLEVRQRSCDVALGLVANVFQYSVLHKLVALECGLEPAEIIWNIHN 217

Query: 264 AHVYSTHVQALEEQLQKQPKPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKMAV 88
            H+Y  H   L EQ+ ++      +KIN  K   D F   D ++  Y   +K+  ++A+
Sbjct: 218 MHIYDRHYDKLIEQVNRETFEPAKIKINNFKSIFD-FKPDDIEIIDYKYGEKVSYEVAI 275
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>TYSY_IDILO (Q5R064) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 283

 Score = 90.5 bits (223), Expect = 4e-18
 Identities = 57/164 (34%), Positives = 86/164 (52%), Gaps = 5/164 (3%)
 Frame = -2

Query: 564 GKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMALPPCHMFAQFYVENGELSCQMYQ 385
           G   DQL  VIN +    DDR  I++ +NP + +   L PC     F +    L    YQ
Sbjct: 120 GSHLDQLKKVINNLSKGIDDRGEIVTFYNPGEFELGCLRPCMHTHNFSLLGDTLYLTSYQ 179

Query: 384 RSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHVIGDAHVYSTHVQALEE-QLQKQP 208
           RS D+ LG+ FN      L  ++AQ+    PG+  H I +AH+Y   ++ + + QL+++P
Sbjct: 180 RSCDVPLGLNFNQIQCFALLALVAQITGHKPGKAYHKIVNAHIYENQLELMRDVQLKREP 239

Query: 207 KPFPILKINPLKK---DIDSFVA-SDFKLACYDPHQKIEMKMAV 88
            P P L INP  K   DI+++V+  DF ++ Y  H  I+   AV
Sbjct: 240 FPSPQLHINPEIKSLEDIETWVSKDDFIVSGYQCHDPIKYPFAV 283
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>TYSY_STAEP (P0C0M4) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) (Fragment)|
          Length = 97

 Score = 88.2 bits (217), Expect = 2e-17
 Identities = 47/98 (47%), Positives = 61/98 (62%)
 Frame = -2

Query: 381 SADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHVIGDAHVYSTHVQALEEQLQKQPKP 202
           SAD+ LGVPFNIASY+LLT ++A+ C L  GEF+H  GDAH+YS H+ A+  QL +    
Sbjct: 1   SADIFLGVPFNIASYALLTHLVAKECGLEVGEFIHTFGDAHIYSNHMDAIHTQLSRDSYL 60

Query: 201 FPILKINPLKKDIDSFVASDFKLACYDPHQKIEMKMAV 88
            P LKIN   K I      D +L  Y+ H  I+  +AV
Sbjct: 61  PPQLKIN-TDKSIFDINYEDLELINYESHPAIKAPIAV 97
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>TYSY_HAEIN (P44420) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 283

 Score = 88.2 bits (217), Expect = 2e-17
 Identities = 52/164 (31%), Positives = 85/164 (51%), Gaps = 5/164 (3%)
 Frame = -2

Query: 564 GKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMALPPCHMFAQFYVENGELSCQMYQ 385
           G+  DQL  ++N +    DDR  IL+ +NP +     L PC     F +    L    YQ
Sbjct: 120 GETIDQLRKIVNNLTKGIDDRGEILTFFNPGEFDLGCLRPCMHTHTFSLVGDTLHLTSYQ 179

Query: 384 RSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHVIGDAHVYSTHVQALEE-QLQKQP 208
           RS D+ LG+ FN         ++AQ+     G+  H I +AH+Y   ++ + + QL+++P
Sbjct: 180 RSCDVPLGLNFNQIQVFTFLALMAQITGKKAGKAYHKIVNAHIYEDQLELMRDVQLKREP 239

Query: 207 KPFPILKINP---LKKDIDSFVA-SDFKLACYDPHQKIEMKMAV 88
            P P L+INP     +D++++V   DFK+  Y  H+ I+   +V
Sbjct: 240 FPLPKLEINPDIKTLEDLETWVTMDDFKVVGYQSHEPIKYPFSV 283
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>TYSY_HAEI8 (Q4QM04) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 283

 Score = 88.2 bits (217), Expect = 2e-17
 Identities = 52/164 (31%), Positives = 85/164 (51%), Gaps = 5/164 (3%)
 Frame = -2

Query: 564 GKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMALPPCHMFAQFYVENGELSCQMYQ 385
           G+  DQL  ++N +    DDR  IL+ +NP +     L PC     F +    L    YQ
Sbjct: 120 GETIDQLRKIVNNLTKGIDDRGEILTFFNPGEFDLGCLRPCMHTHTFSLVGDTLHLTSYQ 179

Query: 384 RSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHVIGDAHVYSTHVQALEE-QLQKQP 208
           RS D+ LG+ FN         ++AQ+     G+  H I +AH+Y   ++ + + QL+++P
Sbjct: 180 RSCDVPLGLNFNQIQVFTFLALMAQITGKKAGKAYHKIVNAHIYEDQLELMRDVQLKREP 239

Query: 207 KPFPILKINP---LKKDIDSFVA-SDFKLACYDPHQKIEMKMAV 88
            P P L+INP     +D++++V   DFK+  Y  H+ I+   +V
Sbjct: 240 FPLPKLEINPDIKTLEDLETWVTMDDFKVVGYQSHEPIKYPFSV 283
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>TYSY_VIBF1 (Q5E7P1) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 283

 Score = 87.0 bits (214), Expect = 4e-17
 Identities = 58/187 (31%), Positives = 93/187 (49%), Gaps = 5/187 (2%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           G VY  Q R +        A   G+  DQL  +I+ +    DDR  IL+ +NP +     
Sbjct: 105 GRVYGVQGRSW--------AKPNGEFVDQLKKIIDDLSQGIDDRGEILNFYNPGEFDMGC 156

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           L PC     F +    L     QRS D+ LG+ FN+     L  ++AQ+     G+  H 
Sbjct: 157 LRPCMYSHHFSLLGDTLYLNSTQRSCDVPLGLNFNMVQVYFLLAIVAQITGHKAGKAYHK 216

Query: 273 IGDAHVYSTHVQALEE-QLQKQPKPFPILKINPLKK---DIDSFVA-SDFKLACYDPHQK 109
           I +AH+Y   ++ ++  QL+++P   PI KINP  K   D++++V   DF++  Y+ H+ 
Sbjct: 217 IVNAHIYEDQLELMQSVQLKREPLQAPIFKINPEIKSLEDLETWVTMDDFEVIGYESHEA 276

Query: 108 IEMKMAV 88
           I+   +V
Sbjct: 277 IKYPFSV 283
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>TYSY_PASMU (P57808) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 283

 Score = 86.3 bits (212), Expect = 7e-17
 Identities = 53/164 (32%), Positives = 84/164 (51%), Gaps = 5/164 (3%)
 Frame = -2

Query: 564 GKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMALPPCHMFAQFYVENGELSCQMYQ 385
           G+  DQL  ++N ++N  DDR  I++ +NP + +   L PC     F +    L    YQ
Sbjct: 120 GETVDQLRKIVNNLRNGIDDRGEIMTFFNPGEFELGCLRPCMHTHTFSLLGDTLYLTSYQ 179

Query: 384 RSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHVIGDAHVYSTHVQALEE-QLQKQP 208
           RS D+ LG+ FN         ++AQ+     G+  H I +AH+Y   +  ++  QL++ P
Sbjct: 180 RSCDVPLGLNFNQIQVFTFLALMAQITGKKAGKAYHKIINAHIYEDQLDLMKNVQLKRDP 239

Query: 207 KPFPILKINPLKK---DIDSFVA-SDFKLACYDPHQKIEMKMAV 88
            P P L INP  K   D++++V   DFK+  Y  H  I+   +V
Sbjct: 240 FPLPQLHINPEIKTLEDLETWVTMDDFKVTGYQCHDAIKYPFSV 283
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>TYSY_MANSM (Q65VJ8) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 283

 Score = 83.2 bits (204), Expect = 6e-16
 Identities = 51/164 (31%), Positives = 83/164 (50%), Gaps = 5/164 (3%)
 Frame = -2

Query: 564 GKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMALPPCHMFAQFYVENGELSCQMYQ 385
           G+  DQL  ++N +    DDR  IL+  NP +     L PC     F +    L    YQ
Sbjct: 120 GETVDQLRKIVNNLSRGIDDRGEILTFLNPGEFDLGCLRPCMYNHTFSLLGDTLYLTSYQ 179

Query: 384 RSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHVIGDAHVYSTHVQALEE-QLQKQP 208
           RS D+ LG+ FN         ++AQ+     G+  H I +AH+Y   ++ + + QL+++P
Sbjct: 180 RSCDVPLGLNFNQIQVFTFLALMAQITGKKAGQAYHKIVNAHIYEDQLELMRDVQLKREP 239

Query: 207 KPFPILKINP---LKKDIDSFVA-SDFKLACYDPHQKIEMKMAV 88
            P P L+INP     +D++++V   DF +  Y  H+ I+   +V
Sbjct: 240 FPSPKLEINPDIKTLEDLETWVTMDDFNVVGYQCHEPIKYPFSV 283
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>TYSY_VIBCH (O66108) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 283

 Score = 81.6 bits (200), Expect = 2e-15
 Identities = 56/187 (29%), Positives = 88/187 (47%), Gaps = 5/187 (2%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           G VY  Q R +        A   G   DQL  +++ +    DDR  IL+ +NP +     
Sbjct: 105 GRVYGVQGRAW--------AKPDGGHIDQLKKIVDDLSRGVDDRGEILNFYNPGEFHMGC 156

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           L PC     F +    L     QRS D+ LG+ FN+    +   ++AQ+    PG   H 
Sbjct: 157 LRPCMYSHHFSLLGDTLYLNSTQRSCDVPLGLNFNMVQVYVFLALMAQITGKKPGLAYHK 216

Query: 273 IGDAHVYSTHVQALEE-QLQKQPKPFPILKINPLKK---DIDSFVA-SDFKLACYDPHQK 109
           I +AH+Y   ++ + + QL+++P P P   INP  K   D++++V   DF +  Y  H  
Sbjct: 217 IVNAHIYQDQLELMRDVQLKREPFPAPQFHINPKIKTLQDLETWVTLDDFDVTGYQFHDP 276

Query: 108 IEMKMAV 88
           I+   +V
Sbjct: 277 IQYPFSV 283
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>TYSY_PHOPR (Q6LUM1) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 283

 Score = 81.3 bits (199), Expect = 2e-15
 Identities = 53/164 (32%), Positives = 80/164 (48%), Gaps = 5/164 (3%)
 Frame = -2

Query: 564 GKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMALPPCHMFAQFYVENGELSCQMYQ 385
           G   DQL  +++ +    DDR  IL+ +NP +     L PC     F +    L    YQ
Sbjct: 120 GSTIDQLRKIVDNLSEGIDDRGEILTFYNPGEFDLGCLRPCMHTHTFSLLGDTLHLTSYQ 179

Query: 384 RSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHVIGDAHVYSTHVQALEE-QLQKQP 208
           RS D+ LG+ FN      L  ++AQ+    PG   H I +AH+Y   +  L + QL + P
Sbjct: 180 RSCDVPLGLNFNQVQVYTLLALVAQITGKKPGLAYHKIINAHIYEDQLSLLRDVQLTRTP 239

Query: 207 KPFPILKINPLKK---DIDSFVA-SDFKLACYDPHQKIEMKMAV 88
              P L INP  K   D++++V   DF +  Y+ H+ I+   +V
Sbjct: 240 FAAPKLIINPKIKCLEDLETWVTMDDFDVIGYEHHEAIKYPFSV 283
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>TYSY_VIBPA (Q87SA0) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 283

 Score = 80.5 bits (197), Expect = 4e-15
 Identities = 55/187 (29%), Positives = 89/187 (47%), Gaps = 5/187 (2%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           G VY  Q R +        A   G   DQL  +++ +    DDR  IL+ +NP +     
Sbjct: 105 GRVYGVQGRAW--------AKPDGGHIDQLRKIVDDLTRGVDDRGEILNFYNPGEFHMGC 156

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           L PC     F + +  L     QRS D+ LG+ FN+    +   ++AQ+    PG+  H 
Sbjct: 157 LRPCMYSHHFSLLDDTLYLNSTQRSCDVPLGLNFNMVQVYVFLAIMAQITGKKPGQAFHK 216

Query: 273 IGDAHVYSTHVQALEE-QLQKQPKPFPILKINPLKK---DIDSFVA-SDFKLACYDPHQK 109
           I +AH+Y   ++ + + QL+++P   P   INP  K   D++++V   DF +  Y+ H  
Sbjct: 217 IVNAHIYEDQLELMRDVQLKREPLQAPTFHINPEIKSLEDLETWVTLDDFWVEGYEHHDP 276

Query: 108 IEMKMAV 88
           I    +V
Sbjct: 277 IRYPFSV 283
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>TYSY_VIBVY (Q7MNN6) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 283

 Score = 79.7 bits (195), Expect = 7e-15
 Identities = 55/187 (29%), Positives = 88/187 (47%), Gaps = 5/187 (2%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           G VY  Q R +        A   G   DQL  +++ +    DDR  IL+ +NP +     
Sbjct: 105 GRVYGVQGRAW--------AKPDGGHIDQLRKIVDDLTRGVDDRGEILNFYNPGEFHMGC 156

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           L PC     F +    L     QRS D+ LG+ FN+    +   ++AQ+    PG+  H 
Sbjct: 157 LRPCMYSHHFSLLGDTLYLNSTQRSCDVPLGLNFNMVQVYVFLAIMAQITGKKPGQAFHK 216

Query: 273 IGDAHVYSTHVQALEE-QLQKQPKPFPILKINPLKK---DIDSFVA-SDFKLACYDPHQK 109
           I +AH+Y   +  + + QL+++P   P   INP  K   D++++V   DF +  Y+ H  
Sbjct: 217 IVNAHIYEDQLALMRDVQLKREPLQAPTFHINPEIKSLEDLETWVTLDDFWVEGYEHHDP 276

Query: 108 IEMKMAV 88
           I+   +V
Sbjct: 277 IQYPFSV 283
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>TYSY_VIBVU (Q8DER9) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 283

 Score = 79.7 bits (195), Expect = 7e-15
 Identities = 55/187 (29%), Positives = 88/187 (47%), Gaps = 5/187 (2%)
 Frame = -2

Query: 633 GPVYXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMA 454
           G VY  Q R +        A   G   DQL  +++ +    DDR  IL+ +NP +     
Sbjct: 105 GRVYGVQGRAW--------AKPDGGHIDQLRKIVDDLTRGVDDRGEILNFYNPGEFHMGC 156

Query: 453 LPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHV 274
           L PC     F +    L     QRS D+ LG+ FN+    +   ++AQ+    PG+  H 
Sbjct: 157 LRPCMYSHHFSLLGDTLYLNSTQRSCDVPLGLNFNMVQVYVFLAIMAQITGKKPGQAFHK 216

Query: 273 IGDAHVYSTHVQALEE-QLQKQPKPFPILKINPLKK---DIDSFVA-SDFKLACYDPHQK 109
           I +AH+Y   +  + + QL+++P   P   INP  K   D++++V   DF +  Y+ H  
Sbjct: 217 IVNAHIYEDQLALMRDVQLKREPLQAPTFHINPEIKSLEDLETWVTLDDFWVEGYEHHDP 276

Query: 108 IEMKMAV 88
           I+   +V
Sbjct: 277 IQYPFSV 283
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>TYSY_HAEDU (Q7VMH2) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 283

 Score = 72.0 bits (175), Expect = 1e-12
 Identities = 44/160 (27%), Positives = 77/160 (48%), Gaps = 5/160 (3%)
 Frame = -2

Query: 552 DQLADVINKIKNNPDDRRIILSAWNPTDLKKMALPPCHMFAQFYVENGELSCQMYQRSAD 373
           D L  +++ + N  D+R  I + ++P       L PC     F + +G L     QRSAD
Sbjct: 124 DLLKQIVDDLSNGIDNRGEIYTFYHPGAFHMGCLRPCLYSHHFSLLDGTLYLNSTQRSAD 183

Query: 372 MGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHVIGDAHVYSTHVQALEE-QLQKQPKPFP 196
           + LG+ +N+        ++AQ+ +   G+  H I +AH+Y   +  + + QL+++P   P
Sbjct: 184 VPLGLNWNMVQCYTFLALMAQITNHKAGQVFHKIVNAHIYEDQLALMRDVQLKREPFATP 243

Query: 195 ILKINPLKKDIDSF----VASDFKLACYDPHQKIEMKMAV 88
            L INP  K ++         DFK+  Y  H  I+   ++
Sbjct: 244 TLTINPAIKSLEDLEIWVTLDDFKVENYFYHPSIQYPFSI 283
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>TYSY_STRMU (Q8DUI4) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 279

 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 45/156 (28%), Positives = 74/156 (47%), Gaps = 8/156 (5%)
 Frame = -2

Query: 561 KGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKM-ALPPCHMFAQFYVEN--GE--LSC 397
           K  D +  ++ +++ NP +RR ++S W+    +K   L PC     F V    GE  L  
Sbjct: 114 KKHDIMNKILKQLEENPWNRRNVISLWDYEAFEKTEGLLPCAFQIMFDVRRVKGEIYLDA 173

Query: 396 QMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHVIGDAHVYSTHVQALEEQLQ 217
            + QRS DM +    N   Y  L  MIA+      G+F + + + H+Y    +  EE L+
Sbjct: 174 TLTQRSNDMLVAHHINAMQYVALQMMIAKHFGWKVGKFFYFVNNLHIYDNQFEQAEELLR 233

Query: 216 KQP---KPFPILKINPLKKDIDSFVASDFKLACYDP 118
           ++P   +P  +L + P K +       DF+L  Y+P
Sbjct: 234 REPVVCQPHLVLNV-PNKTNFFDIKPEDFELLDYEP 268
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>TYSY_STRT1 (Q5M0S7) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 286

 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 48/152 (31%), Positives = 73/152 (48%), Gaps = 11/152 (7%)
 Frame = -2

Query: 540 DVINKI----KNNPDDRRIILSAWNPTDLKKMA-LPPCHMFAQFYV----ENGELSCQMY 388
           D+IN++    + NP +RR ++S W+    ++ A L PC     F V    E+  L   + 
Sbjct: 124 DIINRLLAQLEANPWNRRNVISLWDYEAFEETAGLQPCAFQTMFDVRRVGEDVYLDATLT 183

Query: 387 QRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHVIGDAHVYSTHVQALEEQLQKQP 208
           QRS DM +    N   Y  L  MIA+      G+F + I + H+Y    +  EE L++QP
Sbjct: 184 QRSNDMLVAHHINAMQYVALQMMIAKHFGWKIGKFFYFINNLHIYDNQFEQAEELLKRQP 243

Query: 207 KPF-PILKIN-PLKKDIDSFVASDFKLACYDP 118
               P L +N P + +       DF+L  YDP
Sbjct: 244 SDCQPRLVLNVPDETNFFDIKPEDFELVDYDP 275
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>TYSY_STRA5 (Q8DZ07) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 279

 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 46/150 (30%), Positives = 72/150 (48%), Gaps = 7/150 (4%)
 Frame = -2

Query: 546 LADVINKIKNNPDDRRIILSAWNPTDLKKM-ALPPCHMFAQFYVE--NGEL--SCQMYQR 382
           ++ ++ ++++NP +RR ++S W+    ++   L PC     F V   NGEL     + QR
Sbjct: 119 ISKLLKQLEDNPWNRRNVISLWDYEAFEETEGLLPCAFQTMFDVRRVNGELYLDATLTQR 178

Query: 381 SADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHVIGDAHVYSTHVQALEEQLQKQPKP 202
           S DM +    N   Y  L  MIA+      G+F + I + H+Y    +  +E L++QP  
Sbjct: 179 SNDMLVAHHINAMQYVALQMMIAKHFGWRVGKFFYFINNLHIYDNQFEQAQELLKRQPSE 238

Query: 201 F-PILKIN-PLKKDIDSFVASDFKLACYDP 118
             P L +N P   D       DF L  YDP
Sbjct: 239 CNPKLVLNVPDGTDFFDIKPDDFALVDYDP 268
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>TYSY_STRA3 (Q8E4L6) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 279

 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 46/150 (30%), Positives = 72/150 (48%), Gaps = 7/150 (4%)
 Frame = -2

Query: 546 LADVINKIKNNPDDRRIILSAWNPTDLKKM-ALPPCHMFAQFYVE--NGEL--SCQMYQR 382
           ++ ++ ++++NP +RR ++S W+    ++   L PC     F V   NGEL     + QR
Sbjct: 119 ISKLLKQLEDNPWNRRNVISLWDYEAFEETEGLLPCAFQTMFDVRRVNGELYLDATLTQR 178

Query: 381 SADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHVIGDAHVYSTHVQALEEQLQKQPKP 202
           S DM +    N   Y  L  MIA+      G+F + I + H+Y    +  +E L++QP  
Sbjct: 179 SNDMLVAHHINAMQYVALQMMIAKHFGWRVGKFFYFINNLHIYDNQFEQAQELLKRQPSE 238

Query: 201 F-PILKIN-PLKKDIDSFVASDFKLACYDP 118
             P L +N P   D       DF L  YDP
Sbjct: 239 CNPKLVLNVPDGTDFFDIKPDDFALVDYDP 268
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>TYSY_STRT2 (Q5M5B3) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 286

 Score = 61.2 bits (147), Expect = 2e-09
 Identities = 48/152 (31%), Positives = 73/152 (48%), Gaps = 11/152 (7%)
 Frame = -2

Query: 540 DVINKI----KNNPDDRRIILSAWNPTDLKKMA-LPPCHMFAQFYV----ENGELSCQMY 388
           D+IN++    + NP +RR ++S W+    ++ A L PC     F V    E+  L   + 
Sbjct: 124 DIINRLLAQLEANPWNRRNVISLWDYEAFEETAGLQPCAFQTMFDVRRVGEDVYLDGTLT 183

Query: 387 QRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHVIGDAHVYSTHVQALEEQLQKQP 208
           QRS DM +    N   Y  L  MIA+      G+F + I + H+Y    +  EE L++QP
Sbjct: 184 QRSNDMLVAHHINAMQYVALQMMIAKHFGWKVGKFFYFINNLHIYDNQFEQAEELLKRQP 243

Query: 207 KPF-PILKIN-PLKKDIDSFVASDFKLACYDP 118
               P L +N P + +       DF+L  YDP
Sbjct: 244 SDCQPRLVLNVPDETNFFDIKPEDFELVDYDP 275
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>TYSY_STRR6 (P67050) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 279

 Score = 60.5 bits (145), Expect = 4e-09
 Identities = 48/153 (31%), Positives = 74/153 (48%), Gaps = 12/153 (7%)
 Frame = -2

Query: 540 DVINKI----KNNPDDRRIILSAWNPTDLKKM-ALPPCHMFAQFYVE--NGE--LSCQMY 388
           D+INK+    + NP +RR I+S W+    ++   L PC     F V   +GE  L   + 
Sbjct: 117 DIINKLLKQLETNPWNRRNIISLWDYQAFEETDGLLPCAFQTMFDVRRVDGEIYLDATLT 176

Query: 387 QRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHVIGDAHVYSTHVQALEEQLQKQP 208
           QRS DM +    N   Y  L  MIA+      G+F + I + H+Y    +  +E L+++P
Sbjct: 177 QRSNDMLVAHHINAMQYVALQMMIAKHFGWKVGKFFYFINNLHIYDNQFEQAQELLRREP 236

Query: 207 ---KPFPILKINPLKKDIDSFVASDFKLACYDP 118
              +P  +L + P   +     A DF+L  YDP
Sbjct: 237 SNCQPRLVLNV-PDGTNFFDIKAEDFELVDYDP 268
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>TYSY_STRPN (P67049) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 279

 Score = 60.5 bits (145), Expect = 4e-09
 Identities = 48/153 (31%), Positives = 74/153 (48%), Gaps = 12/153 (7%)
 Frame = -2

Query: 540 DVINKI----KNNPDDRRIILSAWNPTDLKKM-ALPPCHMFAQFYVE--NGE--LSCQMY 388
           D+INK+    + NP +RR I+S W+    ++   L PC     F V   +GE  L   + 
Sbjct: 117 DIINKLLKQLETNPWNRRNIISLWDYQAFEETDGLLPCAFQTMFDVRRVDGEIYLDATLT 176

Query: 387 QRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHVIGDAHVYSTHVQALEEQLQKQP 208
           QRS DM +    N   Y  L  MIA+      G+F + I + H+Y    +  +E L+++P
Sbjct: 177 QRSNDMLVAHHINAMQYVALQMMIAKHFGWKVGKFFYFINNLHIYDNQFEQAQELLRREP 236

Query: 207 ---KPFPILKINPLKKDIDSFVASDFKLACYDP 118
              +P  +L + P   +     A DF+L  YDP
Sbjct: 237 SNCQPRLVLNV-PDGTNFFDIKAEDFELVDYDP 268
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>TYSY_STRP3 (P67052) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 279

 Score = 57.8 bits (138), Expect = 3e-08
 Identities = 43/156 (27%), Positives = 73/156 (46%), Gaps = 8/156 (5%)
 Frame = -2

Query: 561 KGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKM-ALPPCHMFAQFYVEN-GE---LSC 397
           K  D ++ ++ ++  NP +RR ++S W+    ++   L PC     F V   GE   L  
Sbjct: 114 KKHDIISKILKQLAENPWNRRNVISLWDYEAFEETKGLLPCAFQIMFDVRRVGEDLYLDA 173

Query: 396 QMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHVIGDAHVYSTHVQALEEQLQ 217
            + QRS D+ +    N   Y  L  MIA+      G+F + + + H+Y       +E L+
Sbjct: 174 SLTQRSNDILVAHHINAMQYVALQMMIAKHFGWKIGKFFYFVNNLHIYDNQFDQAQELLK 233

Query: 216 KQP---KPFPILKINPLKKDIDSFVASDFKLACYDP 118
           +QP   +P  +L + P + +       DF+L  YDP
Sbjct: 234 RQPVASQPKLVLNV-PDRTNFFDIKPDDFELQNYDP 268
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>TYSY_STRP1 (P67051) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 279

 Score = 57.8 bits (138), Expect = 3e-08
 Identities = 43/156 (27%), Positives = 73/156 (46%), Gaps = 8/156 (5%)
 Frame = -2

Query: 561 KGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKM-ALPPCHMFAQFYVEN-GE---LSC 397
           K  D ++ ++ ++  NP +RR ++S W+    ++   L PC     F V   GE   L  
Sbjct: 114 KKHDIISKILKQLAENPWNRRNVISLWDYEAFEETKGLLPCAFQIMFDVRRVGEDLYLDA 173

Query: 396 QMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHVIGDAHVYSTHVQALEEQLQ 217
            + QRS D+ +    N   Y  L  MIA+      G+F + + + H+Y       +E L+
Sbjct: 174 SLTQRSNDILVAHHINAMQYVALQMMIAKHFGWKIGKFFYFVNNLHIYDNQFDQAQELLK 233

Query: 216 KQP---KPFPILKINPLKKDIDSFVASDFKLACYDP 118
           +QP   +P  +L + P + +       DF+L  YDP
Sbjct: 234 RQPVASQPKLVLNV-PDRTNFFDIKPDDFELQNYDP 268
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>TYSY_STRP8 (Q8P1D1) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 279

 Score = 56.2 bits (134), Expect = 8e-08
 Identities = 43/156 (27%), Positives = 72/156 (46%), Gaps = 8/156 (5%)
 Frame = -2

Query: 561 KGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKM-ALPPCHMFAQFYVEN-GE---LSC 397
           K  D ++ ++ ++  NP +RR ++S W+    ++   L PC     F V   GE   L  
Sbjct: 114 KKHDIISKILKQLAENPWNRRNVISLWDYEAFEETKGLLPCAFQIMFDVRRVGEDLYLDA 173

Query: 396 QMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHVIGDAHVYSTHVQALEEQLQ 217
            + QRS D+ +    N   Y  L  MIA+      G+F + + + H+Y       +E L+
Sbjct: 174 SLTQRSNDILVAHHINAMQYVALQMMIAKHFGWKIGKFFYFVNNLHIYDNQFDQAQELLK 233

Query: 216 KQP---KPFPILKINPLKKDIDSFVASDFKLACYDP 118
           +QP   +P  +L + P   +       DF+L  YDP
Sbjct: 234 RQPVASQPKLVLNV-PDGTNFFDIKPDDFELQNYDP 268
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>TYSY_STRP6 (Q5XCM3) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 279

 Score = 56.2 bits (134), Expect = 8e-08
 Identities = 43/156 (27%), Positives = 72/156 (46%), Gaps = 8/156 (5%)
 Frame = -2

Query: 561 KGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKM-ALPPCHMFAQFYVEN-GE---LSC 397
           K  D ++ ++ ++  NP +RR ++S W+    ++   L PC     F V   GE   L  
Sbjct: 114 KKHDIISKILKQLAENPWNRRNVISLWDYEAFEETKGLLPCAFQIMFDVRRVGEDLYLDA 173

Query: 396 QMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHVIGDAHVYSTHVQALEEQLQ 217
            + QRS D+ +    N   Y  L  MIA+      G+F + + + H+Y       +E L+
Sbjct: 174 SLTQRSNDILVAHHINAMQYVALQMMIAKHFGWKIGKFFYFVNNLHIYDNQFDQAQELLK 233

Query: 216 KQP---KPFPILKINPLKKDIDSFVASDFKLACYDP 118
           +QP   +P  +L + P   +       DF+L  YDP
Sbjct: 234 RQPVASQPKLVLNV-PDGTNFFDIKPDDFELQNYDP 268
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>DUHM_BPSP1 (P31654) Deoxyuridylate hydroxymethyltransferase (EC 2.1.2.-)|
           (Deoxyuridylate hydroxymethylase) (dUMP
           hydroxymethylase) (dUMP-HMase)
          Length = 383

 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 37/121 (30%), Positives = 56/121 (46%), Gaps = 8/121 (6%)
 Frame = -2

Query: 552 DQLADVINKIKNNPDDRRIILSAWNP------TDLKKMALPPCHMFAQFYVENGELSCQM 391
           DQL DV  KIK +PD R+ +   +NP       D K     PC++   F + NG+L   +
Sbjct: 123 DQLRDVYEKIKADPDTRQAVAVIYNPLFDNINNDTKDR---PCNLLLSFKLRNGKLDLSV 179

Query: 390 YQRSADMGLGV-PFNIASYSLLTCMIAQVCDLSPGEFVHVIGDAHVYSTHVQA-LEEQLQ 217
           Y RS D+  G    N+  +S +   +A    +  G +  +    HVY     A + E +Q
Sbjct: 180 YNRSNDLHWGTFGANLCQFSTILEAMATWLGVEVGSYYQITDSLHVYLDDYGAKITEDIQ 239

Query: 216 K 214
           K
Sbjct: 240 K 240
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>TYSY_LACLA (P19368) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 279

 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 39/159 (24%), Positives = 70/159 (44%), Gaps = 9/159 (5%)
 Frame = -2

Query: 567 TGKGFDQLADVINKIKNNPDDRRIILSAWNPTDLKKM-ALPPCHMFAQFYVENGE----- 406
           T K ++ +  +++ +  NP +RR I++ W   D ++   L PC     F V   +     
Sbjct: 111 TVKKYNIIGKLLDGLAKNPWNRRNIINLWQYEDFEETEGLLPCAFQTMFDVRREQDGQIY 170

Query: 405 LSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHVIGDAHVYSTHVQALEE 226
           L   + QRS DM +    N   Y  L  MIA+      G+F + + + H+Y    +   E
Sbjct: 171 LDATLIQRSNDMLVAHHINAMQYVALQMMIAKHFSWKVGKFFYFVNNLHIYDNQFEQANE 230

Query: 225 QLQK---QPKPFPILKINPLKKDIDSFVASDFKLACYDP 118
            +++     +P  +L + P   +       DF+L  Y+P
Sbjct: 231 LVKRTASDKEPRLVLNV-PDGTNFFDIKPEDFELVDYEP 268
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>TYSY_METMA (Q8PXI1) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 217

 Score = 50.4 bits (119), Expect = 4e-06
 Identities = 31/100 (31%), Positives = 44/100 (44%)
 Frame = -2

Query: 552 DQLADVINKIKNNPDDRRIILSAWNPTDLKKMALPPCHMFAQFYVENGELSCQMYQRSAD 373
           DQ+  VI K+K +P  RR     W P    K+   PC +   F + + ++      RS D
Sbjct: 103 DQIEYVIEKLKESPTSRRATAVTWIPPVDTKVNEVPCMILDDFKIRDEKVHLTTLFRSHD 162

Query: 372 MGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHVIGDAHVY 253
            G   P N+   S L   +A+   + PG    V   AHVY
Sbjct: 163 FGGAYPANLYGLSKLLEYVAEKVGVEPGVITTVSISAHVY 202
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>TYSY_METAC (Q8THH4) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 217

 Score = 50.1 bits (118), Expect = 6e-06
 Identities = 31/100 (31%), Positives = 44/100 (44%)
 Frame = -2

Query: 552 DQLADVINKIKNNPDDRRIILSAWNPTDLKKMALPPCHMFAQFYVENGELSCQMYQRSAD 373
           DQ+  VI K++ +P  RR     W P    K+   PC +   F + +G++      RS D
Sbjct: 103 DQIEYVIEKLQESPTSRRATAVTWIPPVDTKVNEVPCMILDDFKIRDGKVHLTTLFRSHD 162

Query: 372 MGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHVIGDAHVY 253
            G   P N+   S L   +A    + PG    V   AHVY
Sbjct: 163 FGGAYPANLYGLSKLLEYVAGRVGVEPGMITTVSISAHVY 202
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>TYSY_METTH (O26868) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 221

 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 32/116 (27%), Positives = 52/116 (44%), Gaps = 2/116 (1%)
 Frame = -2

Query: 558 GFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMALPPCHMFAQFYVENGELSCQMYQRS 379
           G DQL + I ++KN  + RR  +  W+P +       PC +   F + +G L      RS
Sbjct: 107 GVDQLDEAIRRLKNCTESRRATMVTWDPPEDTASDEVPCMILVDFKIRDGRLFTTALWRS 166

Query: 378 ADM-GLGVPFNIASYSLLTCMIAQVCDLSPGEF-VHVIGDAHVYSTHVQALEEQLQ 217
            D+ G   P N    + L   +A    +  G   +H I  AH+Y  + +  EE ++
Sbjct: 167 HDIYGAWFP-NAVGLAYLADHVAAEVGVEVGHITIHSI-SAHIYEVNFKEAEEVIK 220
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>TYSY_METKA (Q8TVL9) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 209

 Score = 43.1 bits (100), Expect = 7e-04
 Identities = 32/118 (27%), Positives = 52/118 (44%), Gaps = 2/118 (1%)
 Frame = -2

Query: 600 GAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNP-TDLKKMALPPCHMFAQF 424
           G EY+  H      G DQ+  ++ ++  + + RR I   W+P  DL +  + PC    Q 
Sbjct: 85  GFEYTYGHRLRRYFGLDQVTKIVERLSESNNTRRAIAVTWDPRRDLDEEEV-PCLTALQL 143

Query: 423 YVENGE-LSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHVIGDAHVY 253
             + G  L    + RS D+G  +  N+ +   L   +A+   L P        +AHVY
Sbjct: 144 QSDGGSGLELHAFYRSWDVGKALVANMIALRRLQEHVAERAGLEPTTLTVYAANAHVY 201
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>TYSY_METJA (Q57931) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 222

 Score = 42.7 bits (99), Expect = 9e-04
 Identities = 33/129 (25%), Positives = 52/129 (40%), Gaps = 5/129 (3%)
 Frame = -2

Query: 624 YXFQXRHFGAEYSDMHADYTGKGFDQLADVINKIKNNPDDRRIILSAWNPT-DLK----K 460
           Y +  R F   Y+D       +  +Q+  +I K+    + RR +   WNP  D++    +
Sbjct: 81  YDYHQRLFEYPYAD-------EKINQIDYIIEKLNQQKNSRRAVAITWNPKIDIEVSRDE 133

Query: 459 MALPPCHMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFV 280
               PC    QF + NG+L   +  RS D  L    N      L   IA+   +  G + 
Sbjct: 134 RGSVPCLQLVQFLIRNGKLYQTVIFRSNDALLAFVSNAIGLITLGEYIAKKVGVGYGTYT 193

Query: 279 HVIGDAHVY 253
           H     H+Y
Sbjct: 194 HHAISMHIY 202
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>TYSY_METTM (P80305) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)|
          Length = 222

 Score = 40.4 bits (93), Expect = 0.004
 Identities = 31/116 (26%), Positives = 50/116 (43%), Gaps = 2/116 (1%)
 Frame = -2

Query: 558 GFDQLADVINKIKNNPDDRRIILSAWNPTDLKKMALPPCHMFAQFYVENGELSCQMYQRS 379
           G DQ+   I ++KN  + RR  +  W+P    +    PC +   F V  G L      RS
Sbjct: 107 GVDQVDRAIERLKNCKESRRATMVTWDPKIDTESDEVPCMILVDFKVREGRLFTTALWRS 166

Query: 378 ADM-GLGVPFNIASYSLLTCMIAQVCDLSPGEF-VHVIGDAHVYSTHVQALEEQLQ 217
            D+ G   P N    + L   +A    +  G   +H I  AH+Y  + +  +E ++
Sbjct: 167 HDIYGAWFP-NAVGLAYLADHVASEVGVEVGHITIHSI-SAHIYEVNFKEAKEVIK 220
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>MOTB_SALTY (P55892) Chemotaxis protein motB (Motility protein B)|
          Length = 309

 Score = 30.8 bits (68), Expect = 3.5
 Identities = 16/48 (33%), Positives = 26/48 (54%), Gaps = 6/48 (12%)
 Frame = -2

Query: 225 QLQKQP------KPFPILKINPLKKDIDSFVASDFKLACYDPHQKIEM 100
           +++KQP      K     ++N L+ D+D  + SD KL    PH KI++
Sbjct: 97  EVEKQPNIDELKKRMEQSRLNKLRGDLDQLIESDPKLRALRPHLKIDL 144
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>SYV_XYLFA (Q9PH12) Valyl-tRNA synthetase (EC 6.1.1.9) (Valine--tRNA ligase)|
            (ValRS)
          Length = 994

 Score = 30.4 bits (67), Expect = 4.6
 Identities = 21/56 (37%), Positives = 32/56 (57%), Gaps = 4/56 (7%)
 Frame = -3

Query: 560  KVLIS*LMSLTRSRITLTIG----VSFCLHGIQQISRRWHFHLATCLHSFMSRMEN 405
            K+++S   +L R R TL +     VS  L G Q++ RR   H AT LH F+ ++E+
Sbjct: 847  KIMVS---ALRRIRSTLNVPPSRRVSLLLQGDQEVDRRRITHFATALH-FLLKLEH 898
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>SYE_BUCAI (P57173) Glutamyl-tRNA synthetase (EC 6.1.1.17) (Glutamate--tRNA|
           ligase) (GluRS)
          Length = 467

 Score = 30.4 bits (67), Expect = 4.6
 Identities = 17/56 (30%), Positives = 29/56 (51%)
 Frame = +1

Query: 433 KHVARWKCHLLEICWIPCRQNDTPIVRVILDLVNDIS*LIKTFPRVVSMHVRIFST 600
           K+  R  C +L+ C+    +      + I  ++ND+S LIK   + +SM +RI  T
Sbjct: 378 KYFTRKNCFILQTCYKKIEKLSIWDNKNISKIINDVSELIKVTKKEISMILRISMT 433
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>FDHD_ERWCT (Q6DB09) Protein fdhD homolog|
          Length = 277

 Score = 30.4 bits (67), Expect = 4.6
 Identities = 21/59 (35%), Positives = 33/59 (55%)
 Frame = -2

Query: 402 SCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDLSPGEFVHVIGDAHVYSTHVQALEE 226
           S +M Q+SA  G+ + F +++ + L   +AQ C+L+   F    G A +Y TH Q L E
Sbjct: 221 SYEMVQKSAMCGVEILFAVSAATSLAVDVAQRCNLTLVGFCRP-GQATIY-THPQRLSE 277
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>INV1_HANAN (P40912) Invertase precursor (EC 3.2.1.26) (Beta-fructofuranosidase|
           2) (Saccharase)
          Length = 550

 Score = 30.0 bits (66), Expect = 6.0
 Identities = 22/69 (31%), Positives = 33/69 (47%)
 Frame = -2

Query: 345 ASYSLLTCMIAQVCDLSPGEFVHVIGDAHVYSTHVQALEEQLQKQPKPFPILKINPLKKD 166
           +S SL+     +  D++P  +   +    VY T    L E L K  +     ++N LK D
Sbjct: 326 SSMSLVRNYTLKYVDVNPENYGLTLIQKPVYDTKETRLNETL-KTLETINEYEVNDLKLD 384

Query: 165 IDSFVASDF 139
             SFVA+DF
Sbjct: 385 KSSFVATDF 393
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>IATR_SHEEP (P62757) Inter-alpha-trypsin inhibitor (ITI) (Inhibitory fragment|
           of ITI) (Fragment)
          Length = 123

 Score = 30.0 bits (66), Expect = 6.0
 Identities = 15/51 (29%), Positives = 23/51 (45%), Gaps = 1/51 (1%)
 Frame = -2

Query: 447 PC-HMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDL 298
           PC  MF +++     ++C+ +     MG G  F      L TC   Q C+L
Sbjct: 13  PCLGMFKRYFYNGTSMACETFYYGGCMGNGNNFPSEKECLQTCRTVQACNL 63
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>IATR_CAPHI (P62756) Inter-alpha-trypsin inhibitor (ITI) (GIK-14) (Inhibitory|
           fragment of ITI) (Fragment)
          Length = 123

 Score = 30.0 bits (66), Expect = 6.0
 Identities = 15/51 (29%), Positives = 23/51 (45%), Gaps = 1/51 (1%)
 Frame = -2

Query: 447 PC-HMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDL 298
           PC  MF +++     ++C+ +     MG G  F      L TC   Q C+L
Sbjct: 13  PCLGMFKRYFYNGTSMACETFYYGGCMGNGNNFPSEKECLQTCRTVQACNL 63
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>AMBP_MESAU (Q60559) AMBP protein precursor [Contains: Alpha-1-microglobulin;|
           Inter-alpha-trypsin inhibitor light chain (ITI-LC)
           (Bikunin) (HI-30); Trypstatin]
          Length = 349

 Score = 29.6 bits (65), Expect = 7.8
 Identities = 14/51 (27%), Positives = 21/51 (41%), Gaps = 1/51 (1%)
 Frame = -2

Query: 447 PC-HMFAQFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCDL 298
           PC  M  ++Y     ++C+ +     +G G  FN     L TC     C L
Sbjct: 238 PCLGMIEKYYYNGASMACETFHYGGCLGNGNNFNSEKECLQTCRTVAACSL 288


  Database: uniprot_sprot.fasta
    Posted date:  May 25, 2006  5:36 PM
  Number of letters in database: 80,573,946
  Number of sequences in database:  219,361
  
Lambda     K      H
   0.318    0.135    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 84,863,256
Number of Sequences: 219361
Number of extensions: 1704205
Number of successful extensions: 5104
Number of sequences better than 10.0: 192
Number of HSP's better than 10.0 without gapping: 4903
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5050
length of database: 80,573,946
effective HSP length: 107
effective length of database: 57,102,319
effective search space used: 5881538857
frameshift window, decay const: 50,  0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
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