ナショナルバイオリソースプロジェクト
-Barley Genetic Resources Database-
menu 
| Clone Name | rbags17b01 |
|---|---|
| Clone Library Name | barley_pub |
>HT1_ARATH (Q2MHE4) Serine/threonine-protein kinase HT1 (EC 2.7.11.1) (High| leaf temperature protein 1) Length = 390 Score = 137 bits (345), Expect = 3e-32 Identities = 63/115 (54%), Positives = 79/115 (68%) Frame = -1 Query: 642 KVVDFGVAFENVYCNTLEDDPGTYRWMAPEMCKRKPYGPKVDVYSFGLVLWELVSGSIPY 463 KV DFG + C + + GTYRWMAPEM K KPY KVDVYSFG+VLWEL + +P+ Sbjct: 227 KVADFGTSCLETQCREAKGNMGTYRWMAPEMIKEKPYTRKVDVYSFGIVLWELTTALLPF 286 Query: 462 EEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIVQTLE 298 + MTP+QAA+AV KN RP +P+SC L L+++CWS P KRP F+ IV LE Sbjct: 287 QGMTPVQAAFAVAEKNERPPLPASCQPALAHLIKRCWSENPSKRPDFSNIVAVLE 341
>M3K11_HUMAN (Q16584) Mitogen-activated protein kinase kinase kinase 11 (EC| 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline-rich kinase) Length = 847 Score = 107 bits (268), Expect = 3e-23 Identities = 53/124 (42%), Positives = 73/124 (58%) Frame = -1 Query: 642 KVVDFGVAFENVYCNTLEDDPGTYRWMAPEMCKRKPYGPKVDVYSFGLVLWELVSGSIPY 463 K+ DFG+A E + T GTY WMAPE+ K + DV+SFG++LWEL++G +PY Sbjct: 264 KITDFGLARE-WHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPY 322 Query: 462 EEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIVQTLENLKTA 283 + L AY V L +PS+CP P QLM CW+ P +RP F I+Q LE L+ Sbjct: 323 RGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQ 382 Query: 282 LDRD 271 + R+ Sbjct: 383 VLRE 386
>M3K10_HUMAN (Q02779) Mitogen-activated protein kinase kinase kinase 10 (EC| 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST) Length = 954 Score = 103 bits (258), Expect = 4e-22 Identities = 49/115 (42%), Positives = 69/115 (60%) Frame = -1 Query: 642 KVVDFGVAFENVYCNTLEDDPGTYRWMAPEMCKRKPYGPKVDVYSFGLVLWELVSGSIPY 463 K+ DFG+A E + T GTY WMAPE+ + + DV+SFG++LWEL++G +PY Sbjct: 245 KITDFGLARE-WHKTTKMSAAGTYAWMAPEVIRLSLFSKSSDVWSFGVLLWELLTGEVPY 303 Query: 462 EEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIVQTLE 298 E+ L AY V L +PS+CP P +L+E+CW P RP F I++ LE Sbjct: 304 REIDALAVAYGVAMNKLTLPIPSTCPEPFARLLEECWDPDPHGRPDFGSILKRLE 358
>MLTK_MOUSE (Q9ESL4) Mitogen-activated protein kinase kinase kinase MLT (EC| 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper-and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) ( Length = 802 Score = 101 bits (252), Expect = 2e-21 Identities = 49/118 (41%), Positives = 72/118 (61%), Gaps = 1/118 (0%) Frame = -1 Query: 642 KVVDFGVA-FENVYCNTLEDDPGTYRWMAPEMCKRKPYGPKVDVYSFGLVLWELVSGSIP 466 K+ DFG + F N T GT+ WMAPE+ + P D YS+G+VLWE+++ +P Sbjct: 148 KICDFGASRFHNH--TTHMSLVGTFPWMAPEVIQSLPVSETCDTYSYGVVLWEMLTREVP 205 Query: 465 YEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIVQTLENL 292 ++ + LQ A+ VV KN R +PSSCP +L+ QCW A +KRP F +I+ LE++ Sbjct: 206 FKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCWEADAKKRPSFKQIISILESM 263
>MLTK_HUMAN (Q9NYL2) Mitogen-activated protein kinase kinase kinase MLT (EC| 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper-and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase Length = 800 Score = 101 bits (252), Expect = 2e-21 Identities = 49/118 (41%), Positives = 72/118 (61%), Gaps = 1/118 (0%) Frame = -1 Query: 642 KVVDFGVA-FENVYCNTLEDDPGTYRWMAPEMCKRKPYGPKVDVYSFGLVLWELVSGSIP 466 K+ DFG + F N T GT+ WMAPE+ + P D YS+G+VLWE+++ +P Sbjct: 148 KICDFGASRFHNH--TTHMSLVGTFPWMAPEVIQSLPVSETCDTYSYGVVLWEMLTREVP 205 Query: 465 YEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIVQTLENL 292 ++ + LQ A+ VV KN R +PSSCP +L+ QCW A +KRP F +I+ LE++ Sbjct: 206 FKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCWEADAKKRPSFKQIISILESM 263
>M3K9_HUMAN (P80192) Mitogen-activated protein kinase kinase kinase 9 (EC| 2.7.11.25) (Mixed lineage kinase 1) Length = 1104 Score = 101 bits (252), Expect = 2e-21 Identities = 50/128 (39%), Positives = 72/128 (56%) Frame = -1 Query: 642 KVVDFGVAFENVYCNTLEDDPGTYRWMAPEMCKRKPYGPKVDVYSFGLVLWELVSGSIPY 463 K+ DFG+A E + T GTY WMAPE+ + + DV+S+G++LWEL++G +P+ Sbjct: 291 KITDFGLARE-WHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPF 349 Query: 462 EEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIVQTLENLKTA 283 + L AY V L +PS+CP P +LME CW+ P RP FT I+ L T Sbjct: 350 RGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQL----TT 405 Query: 282 LDRDGTIE 259 ++ G E Sbjct: 406 IEESGFFE 413
>M3KSL_DROME (Q95UN8) Mitogen-activated protein kinase kinase kinase (EC| 2.7.11.25) (Mixed lineage kinase) (dMLK) (Protein slipper) Length = 1161 Score = 100 bits (250), Expect = 3e-21 Identities = 49/122 (40%), Positives = 68/122 (55%) Frame = -1 Query: 657 QKCCAKVVDFGVAFENVYCNTLEDDPGTYRWMAPEMCKRKPYGPKVDVYSFGLVLWELVS 478 Q+ K+ DFG+A E +Y GTY WM PE+ Y DV+S+G++LWEL++ Sbjct: 282 QQKTLKITDFGLARE-MYNTQRMSAAGTYAWMPPEVISVSTYSKFSDVWSYGVLLWELIT 340 Query: 477 GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIVQTLE 298 G PY+ PL AY V L +P +CP LM+ CW P KRP F EI++ LE Sbjct: 341 GETPYKGFDPLSVAYGVAVNTLTLPIPKTCPETWGALMKSCWQTDPHKRPGFKEILKQLE 400 Query: 297 NL 292 ++ Sbjct: 401 SI 402
>M3K12_HUMAN (Q12852) Mitogen-activated protein kinase kinase kinase 12 (EC| 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK) Length = 859 Score = 100 bits (249), Expect = 4e-21 Identities = 47/115 (40%), Positives = 72/115 (62%) Frame = -1 Query: 642 KVVDFGVAFENVYCNTLEDDPGTYRWMAPEMCKRKPYGPKVDVYSFGLVLWELVSGSIPY 463 K+ DFG + E +T GT WMAPE+ + +P KVD++SFG+VLWEL++G IPY Sbjct: 251 KISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPY 310 Query: 462 EEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIVQTLE 298 +++ + V + +L VPSSCP + L+ QCW+++P RP F +I+ L+ Sbjct: 311 KDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQILLHLD 365
>M3K12_MOUSE (Q60700) Mitogen-activated protein kinase kinase kinase 12 (EC| 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK) Length = 888 Score = 100 bits (249), Expect = 4e-21 Identities = 47/115 (40%), Positives = 72/115 (62%) Frame = -1 Query: 642 KVVDFGVAFENVYCNTLEDDPGTYRWMAPEMCKRKPYGPKVDVYSFGLVLWELVSGSIPY 463 K+ DFG + E +T GT WMAPE+ + +P KVD++SFG+VLWEL++G IPY Sbjct: 284 KISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPY 343 Query: 462 EEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIVQTLE 298 +++ + V + +L VPSSCP + L+ QCW+++P RP F +I+ L+ Sbjct: 344 KDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQILLHLD 398
>M3K12_RAT (Q63796) Mitogen-activated protein kinase kinase kinase 12 (EC| 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK) Length = 888 Score = 99.8 bits (247), Expect = 7e-21 Identities = 47/115 (40%), Positives = 71/115 (61%) Frame = -1 Query: 642 KVVDFGVAFENVYCNTLEDDPGTYRWMAPEMCKRKPYGPKVDVYSFGLVLWELVSGSIPY 463 K+ DFG + E +T GT WMAPE+ + +P KVD++SFG+VLWEL++G IPY Sbjct: 284 KISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPY 343 Query: 462 EEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIVQTLE 298 +++ + V + +L VPSSCP + L+ QCW+ +P RP F +I+ L+ Sbjct: 344 KDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNRKPRNRPSFRQILLHLD 398
>M3KL4_HUMAN (Q5TCX8) Mitogen-activated protein kinase kinase kinase (EC| 2.7.11.25) (Mixed lineage kinase 4) Length = 1036 Score = 99.0 bits (245), Expect = 1e-20 Identities = 47/121 (38%), Positives = 71/121 (58%) Frame = -1 Query: 642 KVVDFGVAFENVYCNTLEDDPGTYRWMAPEMCKRKPYGPKVDVYSFGLVLWELVSGSIPY 463 K+ DFG+A E + T GTY WMAPE+ K + D++S+G++LWEL++G +PY Sbjct: 286 KITDFGLARE-WHRTTKMSTAGTYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLTGEVPY 344 Query: 462 EEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIVQTLENLKTA 283 + L AY V L +PS+CP P +LM++CW P RP F I++ L ++ A Sbjct: 345 RGIDGLAVAYGVAVNKLTLPIPSTCPEPFAKLMKECWQQDPHIRPSFALILEQLTAIEGA 404 Query: 282 L 280 + Sbjct: 405 V 405
>M3K13_HUMAN (O43283) Mitogen-activated protein kinase kinase kinase 13 (EC| 2.7.11.25) (Mixed lineage kinase) (MLK) (Leucine zipper-bearing kinase) Length = 966 Score = 96.3 bits (238), Expect = 8e-20 Identities = 57/152 (37%), Positives = 84/152 (55%), Gaps = 1/152 (0%) Frame = -1 Query: 660 TQKCCAKVVDFGVAFENVYCNTLEDDPGTYRWMAPEMCKRKPYGPKVDVYSFGLVLWELV 481 T K+ DFG + E +T GT WMAPE+ + +P KVD++SFG+VLWEL+ Sbjct: 288 THTDAVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELL 347 Query: 480 SGSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIVQTL 301 +G IPY+++ + V + +L VPS+CP + LM+Q W ++P RP F QTL Sbjct: 348 TGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMKQTWQSKPRNRPSFR---QTL 404 Query: 300 ENLKTA-LDRDGTIEKTPTPSCQEAAQEQNKN 208 +L A D T ++T S E +E K+ Sbjct: 405 MHLDIASADVLATPQETYFKSQAEWREEVKKH 436
>M3K13_PONPY (Q5R8X7) Mitogen-activated protein kinase kinase kinase 13 (EC| 2.7.11.25) Length = 966 Score = 95.1 bits (235), Expect = 2e-19 Identities = 56/152 (36%), Positives = 84/152 (55%), Gaps = 1/152 (0%) Frame = -1 Query: 660 TQKCCAKVVDFGVAFENVYCNTLEDDPGTYRWMAPEMCKRKPYGPKVDVYSFGLVLWELV 481 T K+ DFG + E +T GT W+APE+ + +P KVD++SFG+VLWEL+ Sbjct: 288 THTDAVKISDFGTSKELSDKSTKMSFAGTVAWLAPEVIRNEPVSEKVDIWSFGVVLWELL 347 Query: 480 SGSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIVQTL 301 +G IPY+++ + V + +L VPS+CP + LM+Q W ++P RP F QTL Sbjct: 348 TGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMKQTWQSKPRNRPSFR---QTL 404 Query: 300 ENLKTA-LDRDGTIEKTPTPSCQEAAQEQNKN 208 +L A D T ++T S E +E K+ Sbjct: 405 MHLDIASADVLATPQETYFKSQAEWREEVKKH 436
>TNI3K_RAT (Q7TQP6) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 834 Score = 90.5 bits (223), Expect = 4e-18 Identities = 51/124 (41%), Positives = 73/124 (58%), Gaps = 8/124 (6%) Frame = -1 Query: 645 AKVVDFGVAFENVYCNTLEDD-----PGTYRWMAPEM---CKRKPYGPKVDVYSFGLVLW 490 A V DFG E+ + +L++D PG RWMAPE+ C R Y K DV+S+ L LW Sbjct: 601 AVVADFG---ESRFLQSLDEDNMTKQPGNLRWMAPEVFTQCTR--YTIKADVFSYSLCLW 655 Query: 489 ELVSGSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIV 310 EL++G IP+ + P AA + ++RP + S P P+ L+ + W+A PE RP F+E+V Sbjct: 656 ELLTGEIPFAHLKPAAAAADMAYHHIRPPIGYSIPKPISSLLIRGWNACPEGRPEFSEVV 715 Query: 309 QTLE 298 LE Sbjct: 716 SKLE 719
>TNI3K_MOUSE (Q5GIG6) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 833 Score = 90.1 bits (222), Expect = 5e-18 Identities = 51/124 (41%), Positives = 73/124 (58%), Gaps = 8/124 (6%) Frame = -1 Query: 645 AKVVDFGVAFENVYCNTLEDD-----PGTYRWMAPEM---CKRKPYGPKVDVYSFGLVLW 490 A V DFG E+ + +L++D PG RWMAPE+ C R Y K DV+S+ L LW Sbjct: 600 AVVADFG---ESRFLQSLDEDNMTKQPGNLRWMAPEVFTQCTR--YTIKADVFSYALCLW 654 Query: 489 ELVSGSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIV 310 EL+ G IP+ + P AA + ++RP + S P P+ L+ + W+A PE RP F+E+V Sbjct: 655 ELLIGEIPFAHLKPAAAAADMAYHHIRPPIGYSIPKPISSLLMRGWNACPEGRPEFSEVV 714 Query: 309 QTLE 298 + LE Sbjct: 715 RKLE 718
>TNI3K_HUMAN (Q59H18) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 936 Score = 89.7 bits (221), Expect = 7e-18 Identities = 50/124 (40%), Positives = 73/124 (58%), Gaps = 8/124 (6%) Frame = -1 Query: 645 AKVVDFGVAFENVYCNTLEDD-----PGTYRWMAPEM---CKRKPYGPKVDVYSFGLVLW 490 A V DFG E+ + +L++D PG RWMAPE+ C R Y K DV+S+ L LW Sbjct: 703 AVVADFG---ESRFLQSLDEDNMTKQPGNLRWMAPEVFTQCTR--YTIKADVFSYALCLW 757 Query: 489 ELVSGSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIV 310 E+++G IP+ + P AA + ++RP + S P P+ L+ + W+A PE RP F+E+V Sbjct: 758 EILTGEIPFAHLKPAAAAADMAYHHIRPPIGYSIPKPISSLLIRGWNACPEGRPEFSEVV 817 Query: 309 QTLE 298 LE Sbjct: 818 MKLE 821
>YR831_MIMIV (Q7T6Y2) Putative serine/threonine-protein kinase/receptor R831| precursor (EC 2.7.11.1) Length = 1624 Score = 89.7 bits (221), Expect = 7e-18 Identities = 45/114 (39%), Positives = 68/114 (59%) Frame = -1 Query: 642 KVVDFGVAFENVYCNTLEDDPGTYRWMAPEMCKRKPYGPKVDVYSFGLVLWELVSGSIPY 463 K+ DFG A NT GT W APE+ + + Y K DV+SFG+V+WE+++G P+ Sbjct: 1502 KIADFGFA-RIKEDNTTMTRCGTPCWTAPEVIRGEKYCEKADVFSFGVVMWEVLTGKEPF 1560 Query: 462 EEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIVQTL 301 E ++ + ++ RPI+PS CP +L+++CW A+ KRP TE+VQ L Sbjct: 1561 AECNFMKVSLDILEGG-RPIIPSDCPHEFAKLIKKCWHAKAHKRPTMTEVVQQL 1613 Score = 72.4 bits (176), Expect = 1e-12 Identities = 45/126 (35%), Positives = 64/126 (50%), Gaps = 9/126 (7%) Frame = -1 Query: 642 KVVDFG---VAFENVYCNTLEDDPGTYRWMAPEMCKRKPYGPKV--DVYSFGLVLWELVS 478 KV DFG V E T ++ GT W+APE+ + DVYSFG++LWEL++ Sbjct: 923 KVSDFGLTKVKSELDKKKTNDNIIGTIHWIAPEILNDSTEVDYILADVYSFGIILWELLT 982 Query: 477 GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQ----QLMEQCWSAQPEKRPVFTEIV 310 PY+ MTP A +V+ +RP + T L++QCW + RP F EI+ Sbjct: 983 REQPYKGMTPAAIAVSVIRDGMRPPISDEAVTAHSIEYIDLIKQCWHSDTIIRPTFLEIM 1042 Query: 309 QTLENL 292 L N+ Sbjct: 1043 TRLSNI 1048
>M3LK7_DROME (P83104) Putative mitogen-activated protein kinase kinase kinase| 7-like (EC 2.7.11.25) Length = 393 Score = 88.6 bits (218), Expect = 2e-17 Identities = 52/131 (39%), Positives = 70/131 (53%), Gaps = 7/131 (5%) Frame = -1 Query: 642 KVVDFGVAFENVYCNTLEDDPGTYRWMAPEMCKRKPYGPKVDVYSFGLVLWELVSGSIPY 463 K+ DFG+A + N D GT R+MAPE K Y K DVYSFG++LWEL++ +PY Sbjct: 149 KICDFGLATD--MSNNKTDMQGTLRYMAPEAIKHLKYTAKCDVYSFGIMLWELMTRQLPY 206 Query: 462 EEMTPLQAAYAVV------NKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIVQTL 301 + + YA++ K V S CP ++QLME C PEKRP EI + L Sbjct: 207 SHLENPNSQYAIMKAISSGEKLPMEAVRSDCPEGIKQLMECCMDINPEKRPSMKEIEKFL 266 Query: 300 -ENLKTALDRD 271 E ++ D D Sbjct: 267 GEQYESGTDED 277
>KYK2_DICDI (P18161) Tyrosine-protein kinase 2 (EC 2.7.10.2) (Fragment)| Length = 410 Score = 86.7 bits (213), Expect = 6e-17 Identities = 46/121 (38%), Positives = 65/121 (53%), Gaps = 4/121 (3%) Frame = -1 Query: 642 KVVDFGVAFENVYCNTLEDDPGTY---RWMAPEMCKRKP-YGPKVDVYSFGLVLWELVSG 475 K+ DFG++ E ++ G RW PE+ K Y KVDVY F LV+WE+++G Sbjct: 247 KISDFGLSAEKSREGSMTMTNGGICNPRWRPPELTKNLGHYSEKVDVYCFSLVVWEILTG 306 Query: 474 SIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIVQTLEN 295 IP+ ++ Q + V LRP +P C L+ L+ QCW A P RP FT IV L+ Sbjct: 307 EIPFSDLDGSQRSAQVAYAGLRPPIPEYCDPELKLLLTQCWEADPNDRPPFTYIVNKLKE 366 Query: 294 L 292 + Sbjct: 367 I 367
>MATK_RAT (P41243) Megakaryocyte-associated tyrosine-protein kinase (EC| 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase BATK) Length = 467 Score = 85.9 bits (211), Expect = 1e-16 Identities = 49/126 (38%), Positives = 68/126 (53%), Gaps = 1/126 (0%) Frame = -1 Query: 675 RTFCSTQKCCAKVVDFGVAFENVYCNTLEDDPGTYRWMAPEMCKRKPYGPKVDVYSFGLV 496 R ++ AKV DFG+A + L+ +W APE K + K DV+SFG++ Sbjct: 315 RNILVSEDLVAKVSDFGLAKAELR-KGLDSSRLPVKWTAPEALKNGRFSSKSDVWSFGVL 373 Query: 495 LWELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFT 319 LWE+ S G PY +M+ L+ V K R P SCP P+ LM CW A+P +RP F Sbjct: 374 LWEVFSYGRAPYPKMS-LKEVSEAVEKGYRMEPPDSCPGPVHTLMGSCWEAEPSRRPPFR 432 Query: 318 EIVQTL 301 +IV+ L Sbjct: 433 KIVEKL 438
>KYK1_DICDI (P18160) Non-receptor tyrosine kinase spore lysis A (EC 2.7.10.2)| (Tyrosine-protein kinase 1) Length = 1584 Score = 81.6 bits (200), Expect = 2e-15 Identities = 38/126 (30%), Positives = 72/126 (57%), Gaps = 1/126 (0%) Frame = -1 Query: 663 STQKCCAKVVDFGVA-FENVYCNTLEDDPGTYRWMAPEMCKRKPYGPKVDVYSFGLVLWE 487 S Q K+ DFG++ + + + G +MAPE+ K K DVYS+G+VL+E Sbjct: 1438 SRQDIKCKISDFGLSRLKKEQASQMTQSVGCIPYMAPEVFKGDSNSEKSDVYSYGMVLFE 1497 Query: 486 LVSGSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIVQ 307 L++ P ++M P++ A+ ++ RP +P + + ++++ QCW + P+ RP F +I+ Sbjct: 1498 LLTSDEPQQDMKPMKMAHLAAYESYRPPIPLTTSSKWKEILTQCWDSNPDSRPTFKQIIV 1557 Query: 306 TLENLK 289 L+ ++ Sbjct: 1558 HLKEME 1563
>EPHA1_MOUSE (Q60750) Ephrin type-A receptor 1 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ESK) Length = 977 Score = 81.3 bits (199), Expect = 3e-15 Identities = 50/140 (35%), Positives = 67/140 (47%), Gaps = 10/140 (7%) Frame = -1 Query: 675 RTFCSTQKCCAKVVDFGVAFENVYCNTLEDDPGTY---------RWMAPEMCKRKPYGPK 523 R Q C KV DFG+ L+D GTY RW APE + + Sbjct: 754 RNILVNQNLCCKVSDFGLT------RLLDDFDGTYETQGGKIPIRWTAPEAIAHRIFTTA 807 Query: 522 VDVYSFGLVLWELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSA 346 DV+SFG+V+WE++S G PY EM+ Q + R P CP PL +LM+ CW+ Sbjct: 808 SDVWSFGIVMWEVLSFGDKPYGEMSN-QEVMKSIEDGYRLPPPVDCPAPLYELMKNCWAY 866 Query: 345 QPEKRPVFTEIVQTLENLKT 286 +RP F ++ LE L T Sbjct: 867 DRARRPHFLQLQAHLEQLLT 886
>M3K7_MOUSE (Q62073) Mitogen-activated protein kinase kinase kinase 7 (EC| 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1) Length = 579 Score = 81.3 bits (199), Expect = 3e-15 Identities = 40/118 (33%), Positives = 68/118 (57%), Gaps = 1/118 (0%) Frame = -1 Query: 642 KVVDFGVAFENVYCNTLEDDPGTYRWMAPEMCKRKPYGPKVDVYSFGLVLWELVSGSIPY 463 K+ DFG A + + ++ G+ WMAPE+ + Y K DV+S+G++LWE+++ P+ Sbjct: 172 KICDFGTACD--IQTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPF 229 Query: 462 EEM-TPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIVQTLENL 292 +E+ P V+ RP + + P P++ LM +CWS P +RP EIV+ + +L Sbjct: 230 DEIGGPAFRIMWAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHL 287
>MATK_HUMAN (P42679) Megakaryocyte-associated tyrosine-protein kinase (EC| 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase) Length = 507 Score = 81.3 bits (199), Expect = 3e-15 Identities = 46/126 (36%), Positives = 65/126 (51%), Gaps = 1/126 (0%) Frame = -1 Query: 675 RTFCSTQKCCAKVVDFGVAFENVYCNTLEDDPGTYRWMAPEMCKRKPYGPKVDVYSFGLV 496 R ++ AKV DFG+A L+ +W APE K + K DV+SFG++ Sbjct: 356 RNILVSEDLVAKVSDFGLA--KAERKGLDSSRLPVKWTAPEALKHGKFTSKSDVWSFGVL 413 Query: 495 LWELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFT 319 LWE+ S G PY +M+ L+ V K R P CP P+ LM CW A+P +RP F Sbjct: 414 LWEVFSYGRAPYPKMS-LKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARRPPFR 472 Query: 318 EIVQTL 301 ++ + L Sbjct: 473 KLAEKL 478
>EPHA2_HUMAN (P29317) Ephrin type-A receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) Length = 976 Score = 81.3 bits (199), Expect = 3e-15 Identities = 50/133 (37%), Positives = 70/133 (52%), Gaps = 11/133 (8%) Frame = -1 Query: 642 KVVDFGVAFENVYCNTLEDDP-GTY---------RWMAPEMCKRKPYGPKVDVYSFGLVL 493 KV DFG++ LEDDP TY RW APE + + DV+SFG+V+ Sbjct: 754 KVSDFGLS------RVLEDDPEATYTTSGGKIPIRWTAPEAISYRKFTSASDVWSFGIVM 807 Query: 492 WELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTE 316 WE+++ G PY E++ + A+ N R P CP+ + QLM QCW + +RP F + Sbjct: 808 WEVMTYGERPYWELSNHEVMKAI-NDGFRLPTPMDCPSAIYQLMMQCWQQERARRPKFAD 866 Query: 315 IVQTLENLKTALD 277 IV L+ L A D Sbjct: 867 IVSILDKLIRAPD 879
>M3K7_HUMAN (O43318) Mitogen-activated protein kinase kinase kinase 7 (EC| 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1) Length = 606 Score = 81.3 bits (199), Expect = 3e-15 Identities = 40/118 (33%), Positives = 68/118 (57%), Gaps = 1/118 (0%) Frame = -1 Query: 642 KVVDFGVAFENVYCNTLEDDPGTYRWMAPEMCKRKPYGPKVDVYSFGLVLWELVSGSIPY 463 K+ DFG A + + ++ G+ WMAPE+ + Y K DV+S+G++LWE+++ P+ Sbjct: 172 KICDFGTACD--IQTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPF 229 Query: 462 EEM-TPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIVQTLENL 292 +E+ P V+ RP + + P P++ LM +CWS P +RP EIV+ + +L Sbjct: 230 DEIGGPAFRIMWAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHL 287
>CSK_HUMAN (P41240) Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase)| (Protein-tyrosine kinase CYL) Length = 450 Score = 80.9 bits (198), Expect = 3e-15 Identities = 43/121 (35%), Positives = 66/121 (54%), Gaps = 1/121 (0%) Frame = -1 Query: 645 AKVVDFGVAFENVYCNTLEDDPGTYRWMAPEMCKRKPYGPKVDVYSFGLVLWELVS-GSI 469 AKV DFG+ E +T + +W APE + K + K DV+SFG++LWE+ S G + Sbjct: 328 AKVSDFGLTKEA--SSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRV 385 Query: 468 PYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIVQTLENLK 289 PY + PL+ V K + P CP + ++M+ CW RP F ++ + LE++K Sbjct: 386 PYPRI-PLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWHLDAAMRPSFLQLREQLEHIK 444 Query: 288 T 286 T Sbjct: 445 T 445
>MATK_MOUSE (P41242) Megakaryocyte-associated tyrosine-protein kinase (EC| 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK) Length = 505 Score = 80.5 bits (197), Expect = 4e-15 Identities = 47/126 (37%), Positives = 65/126 (51%), Gaps = 1/126 (0%) Frame = -1 Query: 675 RTFCSTQKCCAKVVDFGVAFENVYCNTLEDDPGTYRWMAPEMCKRKPYGPKVDVYSFGLV 496 R ++ AKV DFG+A L+ +W APE K + K DV+SFG++ Sbjct: 354 RNILVSEDLVAKVSDFGLA--KAERKGLDSSRLPVKWTAPEALKNGRFSSKSDVWSFGVL 411 Query: 495 LWELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFT 319 LWE+ S G PY +M+ L+ V K R P CP + LM CW A+P +RP F Sbjct: 412 LWEVFSYGRAPYPKMS-LKEVSEAVEKGYRMEPPDGCPGSVHTLMGSCWEAEPARRPPFR 470 Query: 318 EIVQTL 301 +IV+ L Sbjct: 471 KIVEKL 476
>EPHA2_MOUSE (Q03145) Ephrin type-A receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2) Length = 977 Score = 80.5 bits (197), Expect = 4e-15 Identities = 49/133 (36%), Positives = 70/133 (52%), Gaps = 11/133 (8%) Frame = -1 Query: 642 KVVDFGVAFENVYCNTLEDDP-GTY---------RWMAPEMCKRKPYGPKVDVYSFGLVL 493 KV DFG++ LEDDP TY RW APE + + DV+S+G+V+ Sbjct: 755 KVSDFGLS------RVLEDDPEATYTTSGGKIPIRWTAPEAISYRKFTSASDVWSYGIVM 808 Query: 492 WELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTE 316 WE+++ G PY E++ + A+ N R P CP+ + QLM QCW + +RP F + Sbjct: 809 WEVMTYGERPYWELSNHEVMKAI-NDGFRLPTPMDCPSAIYQLMMQCWQQERSRRPKFAD 867 Query: 315 IVQTLENLKTALD 277 IV L+ L A D Sbjct: 868 IVSILDKLIRAPD 880
>FGFR1_DROME (Q07407) Fibroblast growth factor receptor homolog 1 precursor (EC| 2.7.10.1) (Protein heartless) Length = 729 Score = 80.5 bits (197), Expect = 4e-15 Identities = 48/156 (30%), Positives = 73/156 (46%), Gaps = 6/156 (3%) Frame = -1 Query: 642 KVVDFGVAFE---NVYCNTLEDDPGTYRWMAPEMCKRKPYGPKVDVYSFGLVLWELVS-G 475 K+ DFG+A + Y + +WMAPE + K Y K DV+S+G++LWE+++ G Sbjct: 571 KIADFGLARDIQSTDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYG 630 Query: 474 SIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIVQTLEN 295 PY + + Y + R P+ C + LM QCW + RP FTEIV+ ++ Sbjct: 631 QQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYMDK 690 Query: 294 LKTALD--RDGTIEKTPTPSCQEAAQEQNKNRLASW 193 L + D I TP +E + L W Sbjct: 691 LLQTKEDYLDVDIANLDTPPSTSDEEEDETDNLQKW 726
>CSK_RAT (P32577) Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase)| Length = 450 Score = 79.7 bits (195), Expect = 7e-15 Identities = 42/121 (34%), Positives = 65/121 (53%), Gaps = 1/121 (0%) Frame = -1 Query: 645 AKVVDFGVAFENVYCNTLEDDPGTYRWMAPEMCKRKPYGPKVDVYSFGLVLWELVS-GSI 469 AKV DFG+ E +T + +W APE + K + K DV+SFG++LWE+ S G + Sbjct: 328 AKVSDFGLTKEA--SSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRV 385 Query: 468 PYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIVQTLENLK 289 PY + PL+ V K + P CP + +M+ CW RP F ++ + LE+++ Sbjct: 386 PYPRI-PLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHIR 444 Query: 288 T 286 T Sbjct: 445 T 445
>FES_MOUSE (P16879) Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2)| (C-Fes) Length = 820 Score = 79.7 bits (195), Expect = 7e-15 Identities = 49/130 (37%), Positives = 71/130 (54%), Gaps = 6/130 (4%) Frame = -1 Query: 660 TQKCCAKVVDFGVAFEN---VY--CNTLEDDPGTYRWMAPEMCKRKPYGPKVDVYSFGLV 496 T+K K+ DFG++ E +Y C+ L P +W APE Y + DV+SFG++ Sbjct: 690 TEKNVLKISDFGMSREEADGIYAACSGLRQVP--VKWTAPEALNYGRYSSESDVWSFGIL 747 Query: 495 LWELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFT 319 LWE S G+ PY +T Q V K R P CP + +LMEQCW+ +P +RP F+ Sbjct: 748 LWETFSLGASPYPNLTNQQTR-EFVEKGHRLPCPELCPDAVFRLMEQCWAYEPGQRPSFS 806 Query: 318 EIVQTLENLK 289 I Q L +++ Sbjct: 807 IICQELHSIR 816
>EPHA1_HUMAN (P21709) Ephrin type-A receptor 1 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EPH) Length = 976 Score = 79.7 bits (195), Expect = 7e-15 Identities = 49/138 (35%), Positives = 66/138 (47%), Gaps = 10/138 (7%) Frame = -1 Query: 675 RTFCSTQKCCAKVVDFGVAFENVYCNTLEDDPGTY---------RWMAPEMCKRKPYGPK 523 R Q C KV DFG+ L+D GTY RW APE + + Sbjct: 753 RNILVNQNLCCKVSDFGLT------RLLDDFDGTYETQGGKIPIRWTAPEAIAHRIFTTA 806 Query: 522 VDVYSFGLVLWELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSA 346 DV+SFG+V+WE++S G PY EM+ Q + R P CP PL +LM+ CW+ Sbjct: 807 SDVWSFGIVMWEVLSFGDKPYGEMSN-QEVMKSIEDGYRLPPPVDCPAPLYELMKNCWAY 865 Query: 345 QPEKRPVFTEIVQTLENL 292 +RP F ++ LE L Sbjct: 866 DRARRPHFQKLQAHLEQL 883
>PHY1_CERPU (P25848) Light-sensor Protein kinase [Includes: Phytochrome; Protein| kinase (EC 2.7.11.1)] Length = 1307 Score = 79.7 bits (195), Expect = 7e-15 Identities = 51/155 (32%), Positives = 74/155 (47%), Gaps = 18/155 (11%) Frame = -1 Query: 642 KVVDFGVAFENVYCNTLEDDP---GTYRWMAPEMC---------------KRKPYGPKVD 517 KV DFG++ + GT RWMAPE+ K Y K D Sbjct: 1151 KVADFGLSKTKDSSTRYSNQTWNRGTNRWMAPEVINLGYESTEGEISFDGKVPKYPLKSD 1210 Query: 516 VYSFGLVLWELVSGSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPE 337 VYSFG+V +E+++G +P+ E +V + +RP +P+ CP L+ L+ CW+ P Sbjct: 1211 VYSFGMVCYEVLTGDVPFPEEKNPNNVKRMVLEGVRPDLPAHCPIELKALITDCWNQDPL 1270 Query: 336 KRPVFTEIVQTLENLKTALDRDGTIEKTPTPSCQE 232 KRP F I Q L+ LK L + + PS +E Sbjct: 1271 KRPSFAVICQKLKYLKYLLMTGFSSYQDSYPSTEE 1305
>LCK_CHICK (P42683) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (Protein-tyrosine kinase C-TKL) (p56tk1) Length = 507 Score = 79.3 bits (194), Expect = 1e-14 Identities = 47/131 (35%), Positives = 68/131 (51%), Gaps = 3/131 (2%) Frame = -1 Query: 660 TQKCCAKVVDFGVA--FENVYCNTLEDDPGTYRWMAPEMCKRKPYGPKVDVYSFGLVLWE 487 ++ C K+ DFG+A E+ E +W APE + K DV+SFG++L E Sbjct: 371 SEALCCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTE 430 Query: 486 LVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIV 310 +V+ G IPY MT + + + R P +CP L +LM QCW QPE+RP F + Sbjct: 431 IVTYGRIPYPGMTNPEVIQNL-ERGYRMPQPDNCPQELYELMMQCWKEQPEERPTFEYMK 489 Query: 309 QTLENLKTALD 277 LE+ TA + Sbjct: 490 SVLEDFFTATE 500
>CTR1_ARATH (Q05609) Serine/threonine-protein kinase CTR1 (EC 2.7.11.1)| Length = 821 Score = 79.3 bits (194), Expect = 1e-14 Identities = 45/125 (36%), Positives = 67/125 (53%), Gaps = 3/125 (2%) Frame = -1 Query: 657 QKCCAKVVDFGVAFENVYCNTL---EDDPGTYRWMAPEMCKRKPYGPKVDVYSFGLVLWE 487 +K KV DFG++ + +T + GT WMAPE+ + +P K DVYSFG++LWE Sbjct: 686 KKYTVKVCDFGLS--RLKASTFLSSKSAAGTPEWMAPEVLRDEPSNEKSDVYSFGVILWE 743 Query: 486 LVSGSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIVQ 307 L + P+ + P Q AV K R +P + + ++E CW+ +P KRP F I+ Sbjct: 744 LATLQQPWGNLNPAQVVAAVGFKCKRLEIPRNLNPQVAAIIEGCWTNEPWKRPSFATIMD 803 Query: 306 TLENL 292 L L Sbjct: 804 LLRPL 808
>FGFR4_RAT (Q498D6) Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1)| (FGFR-4) Length = 800 Score = 79.0 bits (193), Expect = 1e-14 Identities = 43/139 (30%), Positives = 74/139 (53%), Gaps = 4/139 (2%) Frame = -1 Query: 675 RTFCSTQKCCAKVVDFGVA---FENVYCNTLEDDPGTYRWMAPEMCKRKPYGPKVDVYSF 505 R T+ K+ DFG+A Y + +WMAPE + Y + DV+SF Sbjct: 614 RNVLVTEDDVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSF 673 Query: 504 GLVLWELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRP 328 G++LWE+ + G PY + P++ ++++ + R P +CP+ L LM +CW A P +RP Sbjct: 674 GILLWEIFTLGGSPYPGI-PVEELFSLLREGHRMERPPNCPSELYGLMRECWHAAPSQRP 732 Query: 327 VFTEIVQTLENLKTALDRD 271 F ++V+ L+ + A+ + Sbjct: 733 TFKQLVEALDKVLLAVSEE 751
>CSK_CHICK (P41239) Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase)| Length = 450 Score = 78.6 bits (192), Expect = 2e-14 Identities = 42/120 (35%), Positives = 67/120 (55%), Gaps = 1/120 (0%) Frame = -1 Query: 645 AKVVDFGVAFENVYCNTLEDDPGTYRWMAPEMCKRKPYGPKVDVYSFGLVLWELVS-GSI 469 AKV DFG+ E +T + +W APE + K + K DV+SFG++LWE+ S G + Sbjct: 328 AKVSDFGLTKEA--SSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRV 385 Query: 468 PYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIVQTLENLK 289 PY + PL+ V K + P CP + ++M++CW+ P RP F ++ + L ++K Sbjct: 386 PYPRI-PLKDVVPRVEKGYKMDPPDGCPAIVYEVMKKCWTLDPGHRPSFHQLREQLVHIK 444
>EPHA5_HUMAN (P54756) Ephrin type-A receptor 5 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Receptor protein-tyrosine kinase HEK7) Length = 1037 Score = 78.2 bits (191), Expect = 2e-14 Identities = 50/128 (39%), Positives = 62/128 (48%), Gaps = 11/128 (8%) Frame = -1 Query: 642 KVVDFGVAFENVYCNTLEDDPGT----------YRWMAPEMCKRKPYGPKVDVYSFGLVL 493 KV DFG++ LEDDP RW APE + + DV+S+G+V+ Sbjct: 815 KVSDFGLS------RVLEDDPEAAYTTRGGKIPIRWTAPEAIAFRKFTSASDVWSYGIVM 868 Query: 492 WELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTE 316 WE+VS G PY EMT Q V + R P CP L QLM CW + RP F E Sbjct: 869 WEVVSYGERPYWEMTN-QDVIKAVEEGYRLPSPMDCPAALYQLMLDCWQKERNSRPKFDE 927 Query: 315 IVQTLENL 292 IV L+ L Sbjct: 928 IVNMLDKL 935
>FES_HUMAN (P07332) Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2)| (C-Fes) Length = 822 Score = 78.2 bits (191), Expect = 2e-14 Identities = 46/128 (35%), Positives = 69/128 (53%), Gaps = 4/128 (3%) Frame = -1 Query: 660 TQKCCAKVVDFGVAFEN---VYCNTLEDDPGTYRWMAPEMCKRKPYGPKVDVYSFGLVLW 490 T+K K+ DFG++ E VY + +W APE Y + DV+SFG++LW Sbjct: 692 TEKNVLKISDFGMSREEADGVYAASGGSRQVPVKWTAPEALNYGRYSSESDVWSFGILLW 751 Query: 489 ELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEI 313 E S G+ PY ++ Q V K R P CP + +LMEQCW+ +P +RP F+ I Sbjct: 752 ETFSLGASPYPNLSNQQTR-EFVEKGGRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSTI 810 Query: 312 VQTLENLK 289 Q L++++ Sbjct: 811 YQELQSIR 818
>EPHA3_BRARE (O13146) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ZEK1) (EPH-like kinase 1) Length = 981 Score = 77.8 bits (190), Expect = 3e-14 Identities = 49/139 (35%), Positives = 65/139 (46%), Gaps = 11/139 (7%) Frame = -1 Query: 675 RTFCSTQKCCAKVVDFGVAFENVYCNTLEDDPGT----------YRWMAPEMCKRKPYGP 526 R + KV DFG++ LEDDP RW APE + + Sbjct: 755 RNILVNRNLVCKVSDFGLS------RVLEDDPEAAYTTRGGKIPIRWTAPEAITYRKFTS 808 Query: 525 KVDVYSFGLVLWELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWS 349 DV+S+G+V+WE++S G PY EM+ Q V++ R P CP L QLM CW Sbjct: 809 ASDVWSYGIVMWEVISYGERPYWEMSN-QDVIKAVDEGYRLPAPMDCPVVLHQLMLDCWE 867 Query: 348 AQPEKRPVFTEIVQTLENL 292 RP F +IV TL+ L Sbjct: 868 KNRSDRPKFGQIVNTLDRL 886
>EPHA5_MOUSE (Q60629) Ephrin type-A receptor 5 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Brain-specific kinase) (CEK-7) Length = 877 Score = 77.4 bits (189), Expect = 4e-14 Identities = 50/128 (39%), Positives = 61/128 (47%), Gaps = 11/128 (8%) Frame = -1 Query: 642 KVVDFGVAFENVYCNTLEDDPGT----------YRWMAPEMCKRKPYGPKVDVYSFGLVL 493 KV DFG++ LEDDP RW APE + + DV+S+G+V+ Sbjct: 654 KVSDFGLS------RVLEDDPEAAYTTRGGKIPIRWTAPEAIAFRKFTSASDVWSYGIVM 707 Query: 492 WELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTE 316 WE+VS G PY EMT Q V + R P CP L QLM CW RP F E Sbjct: 708 WEVVSYGERPYWEMTN-QDVIKAVEEGYRLPSPMDCPAALYQLMLDCWQKDRNSRPKFDE 766 Query: 315 IVQTLENL 292 IV L+ L Sbjct: 767 IVNMLDKL 774
>FGFR4_HUMAN (P22455) Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1)| (FGFR-4) (CD334 antigen) Length = 802 Score = 77.4 bits (189), Expect = 4e-14 Identities = 43/139 (30%), Positives = 72/139 (51%), Gaps = 4/139 (2%) Frame = -1 Query: 675 RTFCSTQKCCAKVVDFGVA---FENVYCNTLEDDPGTYRWMAPEMCKRKPYGPKVDVYSF 505 R T+ K+ DFG+A Y + +WMAPE + Y + DV+SF Sbjct: 616 RNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSF 675 Query: 504 GLVLWELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRP 328 G++LWE+ + G PY + P++ ++++ + R P CP L LM +CW A P +RP Sbjct: 676 GILLWEIFTLGGSPYPGI-PVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRP 734 Query: 327 VFTEIVQTLENLKTALDRD 271 F ++V+ L+ + A+ + Sbjct: 735 TFKQLVEALDKVLLAVSEE 753
>EPHA8_RAT (P29321) Ephrin type-A receptor 8 (EC 2.7.10.1) (Tyrosine-protein| kinase receptor EEK) (EPH- and ELK-related kinase) (Fragment) Length = 372 Score = 77.4 bits (189), Expect = 4e-14 Identities = 51/148 (34%), Positives = 70/148 (47%), Gaps = 14/148 (9%) Frame = -1 Query: 642 KVVDFGVAFENVYCNTLEDDPGT----------YRWMAPEMCKRKPYGPKVDVYSFGLVL 493 KV DFG++ LEDDP RW APE + + DV+SFG+V+ Sbjct: 142 KVSDFGLS------RALEDDPEAAYTTAGGKIPIRWTAPEAIAFRTFSSASDVWSFGVVM 195 Query: 492 WELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTE 316 WE+++ G PY MT Q + V + R P CP L QLM CW +RP F+ Sbjct: 196 WEVLAYGERPYWNMTN-QDVISSVEEGYRLPAPMGCPRALHQLMLDCWHKDRAQRPRFSH 254 Query: 315 IVQTLENL---KTALDRDGTIEKTPTPS 241 +V LE L +L T+ + P P+ Sbjct: 255 VVSVLEALVHSPESLRATATVSRCPAPA 282
>EPHA6_MOUSE (Q62413) Ephrin type-A receptor 6 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2) Length = 1035 Score = 77.0 bits (188), Expect = 5e-14 Identities = 47/128 (36%), Positives = 63/128 (49%), Gaps = 11/128 (8%) Frame = -1 Query: 642 KVVDFGVAFENVYCNTLEDDPGT----------YRWMAPEMCKRKPYGPKVDVYSFGLVL 493 KV DFG++ LEDDP RW APE + + D +S+G+V+ Sbjct: 812 KVSDFGLS------RVLEDDPEAAYTTTGGKIPIRWTAPEAIAYRKFSSASDAWSYGIVM 865 Query: 492 WELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTE 316 WE++S G PY EM+ Q + + R P CP LQQLM CW + RP FT+ Sbjct: 866 WEVMSYGERPYWEMSN-QDVILSIEEGYRLPAPMGCPPSLQQLMLHCWQKERNHRPKFTD 924 Query: 315 IVQTLENL 292 IV L+ L Sbjct: 925 IVSFLDKL 932
>FES_FSVGA (P00542) Tyrosine-protein kinase transforming protein Fes (EC| 2.7.10.2) Length = 609 Score = 76.6 bits (187), Expect = 6e-14 Identities = 45/128 (35%), Positives = 69/128 (53%), Gaps = 4/128 (3%) Frame = -1 Query: 660 TQKCCAKVVDFGV---AFENVYCNTLEDDPGTYRWMAPEMCKRKPYGPKVDVYSFGLVLW 490 T+K K+ DFG+ A + +Y + +W APE Y + DV+SFG++LW Sbjct: 479 TEKNVLKISDFGMSREAADGIYAASGGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLW 538 Query: 489 ELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEI 313 E S G+ PY ++ Q V K R P CP + +LMEQCW+ +P +RP F+ I Sbjct: 539 ETFSLGASPYPNLSNQQTR-EFVEKGGRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSAI 597 Query: 312 VQTLENLK 289 Q L++++ Sbjct: 598 YQELQSIR 605
>EPHA6_RAT (P54758) Ephrin type-A receptor 6 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2) Length = 1035 Score = 76.6 bits (187), Expect = 6e-14 Identities = 47/128 (36%), Positives = 63/128 (49%), Gaps = 11/128 (8%) Frame = -1 Query: 642 KVVDFGVAFENVYCNTLEDDPGT----------YRWMAPEMCKRKPYGPKVDVYSFGLVL 493 KV DFG++ LEDDP RW APE + + DV+S+G+V+ Sbjct: 812 KVSDFGLS------RVLEDDPEAAYTTTGGKIPIRWTAPEAIAYRKFSSASDVWSYGIVM 865 Query: 492 WELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTE 316 WE++S G PY EM+ Q + + R P CP L QLM CW + RP FT+ Sbjct: 866 WEVMSYGERPYWEMSN-QDVILSIEEGYRLPAPMGCPPSLHQLMLHCWQKERNHRPKFTD 924 Query: 315 IVQTLENL 292 IV L+ L Sbjct: 925 IVSFLDKL 932
>EPHB3_HUMAN (P54753) Ephrin type-B receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor HEK-2) Length = 998 Score = 76.6 bits (187), Expect = 6e-14 Identities = 50/130 (38%), Positives = 67/130 (51%), Gaps = 13/130 (10%) Frame = -1 Query: 642 KVVDFGVAFENVYCNTLEDDPG--TY----------RWMAPEMCKRKPYGPKVDVYSFGL 499 KV DFG++ LEDDP TY RW APE + + DV+S+G+ Sbjct: 773 KVSDFGLS------RFLEDDPSDPTYTSSLGGKIPIRWTAPEAIAYRKFTSASDVWSYGI 826 Query: 498 VLWELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVF 322 V+WE++S G PY +M+ Q V ++ R P CPT L QLM CW RP F Sbjct: 827 VMWEVMSYGERPYWDMSN-QDVINAVEQDYRLPPPMDCPTALHQLMLDCWVRDRNLRPKF 885 Query: 321 TEIVQTLENL 292 ++IV TL+ L Sbjct: 886 SQIVNTLDKL 895
>KIT_FSVHZ (P04048) Tyrosine-protein kinase transforming protein kit (EC| 2.7.10.1) Length = 370 Score = 76.6 bits (187), Expect = 6e-14 Identities = 38/95 (40%), Positives = 52/95 (54%), Gaps = 1/95 (1%) Frame = -1 Query: 570 RWMAPEMCKRKPYGPKVDVYSFGLVLWELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPS 394 +WMAPE Y + DV+S+G+ LWEL S GS PY M Y ++ + R + P Sbjct: 272 KWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPE 331 Query: 393 SCPTPLQQLMEQCWSAQPEKRPVFTEIVQTLENLK 289 P + +M+ CW A P KRP F +IVQ +E K Sbjct: 332 HAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQK 366
>EPHB3_MOUSE (P54754) Ephrin type-B receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor MDK-5) (Developmental kinase 5) (SEK-4) Length = 993 Score = 76.6 bits (187), Expect = 6e-14 Identities = 50/130 (38%), Positives = 67/130 (51%), Gaps = 13/130 (10%) Frame = -1 Query: 642 KVVDFGVAFENVYCNTLEDDPG--TY----------RWMAPEMCKRKPYGPKVDVYSFGL 499 KV DFG++ LEDDP TY RW APE + + DV+S+G+ Sbjct: 768 KVSDFGLS------RFLEDDPSDPTYTSSLGGKIPIRWTAPEAIAYRKFTSASDVWSYGI 821 Query: 498 VLWELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVF 322 V+WE++S G PY +M+ Q V ++ R P CPT L QLM CW RP F Sbjct: 822 VMWEVMSYGERPYWDMSN-QDVINAVEQDYRLPPPMDCPTALHQLMLDCWVRDRNLRPKF 880 Query: 321 TEIVQTLENL 292 ++IV TL+ L Sbjct: 881 SQIVNTLDKL 890
>CEK3_CHICK (P18461) Tyrosine kinase receptor CEK3 precursor (EC 2.7.10.1)| Length = 823 Score = 76.6 bits (187), Expect = 6e-14 Identities = 45/150 (30%), Positives = 77/150 (51%), Gaps = 10/150 (6%) Frame = -1 Query: 675 RTFCSTQKCCAKVVDFGVA--FENV-YCNTLEDDPGTYRWMAPEMCKRKPYGPKVDVYSF 505 R T+ K+ DFG+A N+ Y + +WMAPE + Y + DV+SF Sbjct: 632 RNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSF 691 Query: 504 GLVLWELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRP 328 G+++WE+ + G PY + P++ + ++ + R P++C L +M CW A P +RP Sbjct: 692 GVLMWEIFTLGGSPYPGI-PVEELFKLLKEGHRMDKPANCTNELYMMMRDCWQAVPSQRP 750 Query: 327 VFTEIVQTLENLKTA------LDRDGTIEK 256 F ++V+ L+ + T LD G +E+ Sbjct: 751 TFKQLVEDLDRILTLTTNEEYLDLSGPLEQ 780
>EPHA5_RAT (P54757) Ephrin type-A receptor 5 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) Length = 1005 Score = 76.3 bits (186), Expect = 8e-14 Identities = 49/128 (38%), Positives = 61/128 (47%), Gaps = 11/128 (8%) Frame = -1 Query: 642 KVVDFGVAFENVYCNTLEDDPGT----------YRWMAPEMCKRKPYGPKVDVYSFGLVL 493 KV DFG++ LEDDP RW APE + + DV+S+G+V+ Sbjct: 817 KVSDFGLS------RVLEDDPEAAYTTRGGKIPIRWTAPEAIAFRKFTSASDVWSYGIVM 870 Query: 492 WELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTE 316 WE+VS G PY EMT Q V + R P CP L QLM CW RP F + Sbjct: 871 WEVVSYGERPYWEMTN-QDVIKAVEEGYRLPSPMDCPAALYQLMLDCWQKDRNSRPKFDD 929 Query: 315 IVQTLENL 292 IV L+ L Sbjct: 930 IVNMLDKL 937
>FGFR3_MOUSE (Q61851) Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1)| (FGFR-3) (Heparin-binding growth factor receptor) Length = 801 Score = 76.3 bits (186), Expect = 8e-14 Identities = 44/140 (31%), Positives = 74/140 (52%), Gaps = 5/140 (3%) Frame = -1 Query: 675 RTFCSTQKCCAKVVDFGVAFE--NV-YCNTLEDDPGTYRWMAPEMCKRKPYGPKVDVYSF 505 R T+ K+ DFG+A + N+ Y + +WMAPE + Y + DV+SF Sbjct: 615 RNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSF 674 Query: 504 GLVLWELVS--GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKR 331 G++LWE+ + G PY + P++ + ++ + R P+SC L +M +CW A P +R Sbjct: 675 GVLLWEIFTPGGPSPYPGI-PVEELFKLLKEGHRMDKPASCTHDLYMIMRECWHAVPSQR 733 Query: 330 PVFTEIVQTLENLKTALDRD 271 P F ++V+ L+ + T D Sbjct: 734 PTFKQLVEDLDRILTVTSTD 753
>FES_FELCA (P14238) Proto-oncogene tyrosine-protein kinase FES/FPS (EC 2.7.10.2)| (C-FES) Length = 820 Score = 76.3 bits (186), Expect = 8e-14 Identities = 45/128 (35%), Positives = 69/128 (53%), Gaps = 4/128 (3%) Frame = -1 Query: 660 TQKCCAKVVDFGVAFEN---VYCNTLEDDPGTYRWMAPEMCKRKPYGPKVDVYSFGLVLW 490 T+K K+ DFG++ E +Y + +W APE Y + DV+SFG++LW Sbjct: 690 TEKNVLKISDFGMSREEADGIYAASGGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLW 749 Query: 489 ELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEI 313 E S G+ PY ++ Q V K R P CP + +LMEQCW+ +P +RP F+ I Sbjct: 750 ETFSLGASPYPNLSNQQTR-EFVEKGGRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSAI 808 Query: 312 VQTLENLK 289 Q L++++ Sbjct: 809 YQELQSIR 816
>EPHA5_CHICK (P54755) Ephrin type-A receptor 5 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor CEK7) Length = 1013 Score = 76.3 bits (186), Expect = 8e-14 Identities = 49/128 (38%), Positives = 61/128 (47%), Gaps = 11/128 (8%) Frame = -1 Query: 642 KVVDFGVAFENVYCNTLEDDPGT----------YRWMAPEMCKRKPYGPKVDVYSFGLVL 493 KV DFG++ LEDDP RW APE + + DV+S+G+V+ Sbjct: 791 KVSDFGLS------RVLEDDPEAAYTTRGGKIPIRWTAPEAIAFRKFTSASDVWSYGIVM 844 Query: 492 WELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTE 316 WE++S G PY EMT Q V + R P CP L QLM CW RP F E Sbjct: 845 WEVMSYGERPYWEMTN-QDVIKAVEEGYRLPSPMDCPAALYQLMLDCWQKDRNSRPKFDE 903 Query: 315 IVQTLENL 292 IV L+ L Sbjct: 904 IVSMLDKL 911
>MUSK_HUMAN (O15146) Muscle, skeletal receptor tyrosine protein kinase precursor| (EC 2.7.10.1) (Muscle-specific tyrosine protein kinase receptor) (Muscle-specific kinase receptor) (MuSK) Length = 869 Score = 76.3 bits (186), Expect = 8e-14 Identities = 45/121 (37%), Positives = 62/121 (51%), Gaps = 4/121 (3%) Frame = -1 Query: 642 KVVDFGVA---FENVYCNTLEDDPGTYRWMAPEMCKRKPYGPKVDVYSFGLVLWELVS-G 475 K+ DFG++ + Y E+D RWM PE Y + DV+++G+VLWE+ S G Sbjct: 740 KIADFGLSRNIYSADYYKANENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYG 799 Query: 474 SIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIVQTLEN 295 PY M + Y V + N+ P +CP L LM CWS P RP FT I + LE Sbjct: 800 LQPYYGMAHEEVIYYVRDGNILSC-PENCPVELYNLMRLCWSKLPADRPSFTSIHRILER 858 Query: 294 L 292 + Sbjct: 859 M 859
>PGFRA_MOUSE (P26618) Alpha platelet-derived growth factor receptor precursor (EC| 2.7.10.1) (PDGF-R-alpha) Length = 1089 Score = 76.3 bits (186), Expect = 8e-14 Identities = 40/121 (33%), Positives = 64/121 (52%), Gaps = 4/121 (3%) Frame = -1 Query: 642 KVVDFGVAFENVYCNTLEDDPGTY---RWMAPEMCKRKPYGPKVDVYSFGLVLWELVS-G 475 K+ DFG+A + ++ + T+ +WMAPE Y DV+S+G++LWE+ S G Sbjct: 833 KICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLG 892 Query: 474 SIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIVQTLEN 295 PY M Y + R P + + ++M QCW+++PEKRP F + + +EN Sbjct: 893 GTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVQCWNSEPEKRPSFYHLSEIVEN 952 Query: 294 L 292 L Sbjct: 953 L 953
>EPHB3_CHICK (Q07498) Ephrin type-B receptor 3 (EC 2.7.10.1) (Tyrosine-protein| kinase receptor CEK10) (Fragment) Length = 988 Score = 76.3 bits (186), Expect = 8e-14 Identities = 50/130 (38%), Positives = 66/130 (50%), Gaps = 13/130 (10%) Frame = -1 Query: 642 KVVDFGVAFENVYCNTLEDDPG--TY----------RWMAPEMCKRKPYGPKVDVYSFGL 499 KV DFG++ LEDDP TY RW APE + + DV+S+G+ Sbjct: 763 KVSDFGLS------RFLEDDPADPTYTSSLGGKIPIRWTAPEAIAYRKFTSASDVWSYGI 816 Query: 498 VLWELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVF 322 V+WE++S G PY +M+ Q V ++ R P CPT L QLM CW RP F Sbjct: 817 VMWEVMSYGERPYWDMSN-QDVINAVEQDYRLPPPMDCPTALHQLMLDCWVRDRNLRPKF 875 Query: 321 TEIVQTLENL 292 +IV TL+ L Sbjct: 876 AQIVNTLDKL 885
>FGFR3_HUMAN (P22607) Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1)| (FGFR-3) (CD333 antigen) Length = 806 Score = 75.9 bits (185), Expect = 1e-13 Identities = 43/139 (30%), Positives = 74/139 (53%), Gaps = 4/139 (2%) Frame = -1 Query: 675 RTFCSTQKCCAKVVDFGVAFE--NV-YCNTLEDDPGTYRWMAPEMCKRKPYGPKVDVYSF 505 R T+ K+ DFG+A + N+ Y + +WMAPE + Y + DV+SF Sbjct: 621 RNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSF 680 Query: 504 GLVLWELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRP 328 G++LWE+ + G PY + P++ + ++ + R P++C L +M +CW A P +RP Sbjct: 681 GVLLWEIFTLGGSPYPGI-PVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRP 739 Query: 327 VFTEIVQTLENLKTALDRD 271 F ++V+ L+ + T D Sbjct: 740 TFKQLVEDLDRVLTVTSTD 758
>CEK2_CHICK (P18460) Tyrosine kinase receptor CEK2 precursor (EC 2.7.10.1)| Length = 806 Score = 75.9 bits (185), Expect = 1e-13 Identities = 43/139 (30%), Positives = 74/139 (53%), Gaps = 4/139 (2%) Frame = -1 Query: 675 RTFCSTQKCCAKVVDFGVAFE--NV-YCNTLEDDPGTYRWMAPEMCKRKPYGPKVDVYSF 505 R T+ K+ DFG+A + N+ Y + +WMAPE + Y + DV+SF Sbjct: 615 RNVLVTEDNVMKIADFGLARDVHNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSF 674 Query: 504 GLVLWELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRP 328 G++LWE+ + G PY + P++ + ++ + R P++C L +M +CW A P +RP Sbjct: 675 GVLLWEIFTLGGSPYPGI-PVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAVPSQRP 733 Query: 327 VFTEIVQTLENLKTALDRD 271 F ++V+ L+ + T D Sbjct: 734 TFKQLVEDLDRVLTMTSTD 752
>FGFR4_MOUSE (Q03142) Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1)| (FGFR-4) (Protein-tyrosine kinase receptor MPK-11) Length = 799 Score = 75.9 bits (185), Expect = 1e-13 Identities = 42/139 (30%), Positives = 73/139 (52%), Gaps = 4/139 (2%) Frame = -1 Query: 675 RTFCSTQKCCAKVVDFGVA---FENVYCNTLEDDPGTYRWMAPEMCKRKPYGPKVDVYSF 505 R T+ K+ DFG+A Y + +WMAPE + Y + DV+SF Sbjct: 613 RNVLVTEDDVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSF 672 Query: 504 GLVLWELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRP 328 ++LWE+ + G PY + P++ ++++ + R P +CP+ L LM +CW A P +RP Sbjct: 673 EILLWEIFTLGGSPYPGI-PVEELFSLLREGHRMERPPNCPSELYGLMRECWHAAPSQRP 731 Query: 327 VFTEIVQTLENLKTALDRD 271 F ++V+ L+ + A+ + Sbjct: 732 TFKQLVEALDKVLLAVSEE 750
>FGFR2_MOUSE (P21803) Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1)| (FGFR-2) (Keratinocyte growth factor receptor) Length = 821 Score = 75.9 bits (185), Expect = 1e-13 Identities = 42/145 (28%), Positives = 75/145 (51%), Gaps = 4/145 (2%) Frame = -1 Query: 675 RTFCSTQKCCAKVVDFGVA--FENV-YCNTLEDDPGTYRWMAPEMCKRKPYGPKVDVYSF 505 R T+ K+ DFG+A N+ Y + +WMAPE + Y + DV+SF Sbjct: 630 RNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSF 689 Query: 504 GLVLWELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRP 328 G+++WE+ + G PY + P++ + ++ + R P++C L +M CW A P +RP Sbjct: 690 GVLMWEIFTLGGSPYPGI-PVEELFKLLKEGHRMDKPTNCTNELYMMMRDCWHAVPSQRP 748 Query: 327 VFTEIVQTLENLKTALDRDGTIEKT 253 F ++V+ L+ + T + ++ T Sbjct: 749 TFKQLVEDLDRILTLTTNEEYLDLT 773
>PGFRA_RAT (P20786) Alpha platelet-derived growth factor receptor precursor (EC| 2.7.10.1) (PDGF-R-alpha) Length = 1088 Score = 75.9 bits (185), Expect = 1e-13 Identities = 40/121 (33%), Positives = 64/121 (52%), Gaps = 4/121 (3%) Frame = -1 Query: 642 KVVDFGVAFENVYCNTLEDDPGTY---RWMAPEMCKRKPYGPKVDVYSFGLVLWELVS-G 475 K+ DFG+A + ++ + T+ +WMAPE Y DV+S+G++LWE+ S G Sbjct: 832 KICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGVLLWEIFSLG 891 Query: 474 SIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIVQTLEN 295 PY M Y + R P + + ++M QCW+++PEKRP F + + +EN Sbjct: 892 GTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVQCWNSEPEKRPSFYHLSEIVEN 951 Query: 294 L 292 L Sbjct: 952 L 952
>EPHA8_HUMAN (P29322) Ephrin type-A receptor 8 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) (HEK3) Length = 1005 Score = 75.5 bits (184), Expect = 1e-13 Identities = 50/148 (33%), Positives = 71/148 (47%), Gaps = 14/148 (9%) Frame = -1 Query: 642 KVVDFGVAFENVYCNTLEDDPGT----------YRWMAPEMCKRKPYGPKVDVYSFGLVL 493 KV DFG++ LEDDP RW APE + + DV+SFG+V+ Sbjct: 775 KVSDFGLS------RVLEDDPDAAYTTTGGKIPIRWTAPEAIAFRTFSSASDVWSFGVVM 828 Query: 492 WELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTE 316 WE+++ G PY MT + + V + R P CP L QLM CW +RP F++ Sbjct: 829 WEVLAYGERPYWNMTN-RDVISSVEEGYRLPAPMGCPHALHQLMLDCWHKDRAQRPRFSQ 887 Query: 315 IVQTLENL---KTALDRDGTIEKTPTPS 241 IV L+ L +L T+ + P P+ Sbjct: 888 IVSVLDALIRSPESLRATATVSRCPPPA 915
>PTK6_MOUSE (Q64434) Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related| intestinal kinase) Length = 451 Score = 75.5 bits (184), Expect = 1e-13 Identities = 46/132 (34%), Positives = 70/132 (53%), Gaps = 4/132 (3%) Frame = -1 Query: 675 RTFCSTQKCCAKVVDFGVAF---ENVYCNTLEDDPGTYRWMAPEMCKRKPYGPKVDVYSF 505 R T+ KV DFG+A E++Y + + P Y+W APE R Y K DV+SF Sbjct: 316 RNVLVTENNLCKVGDFGLARLVKEDIYLSHEHNVP--YKWTAPEALSRGHYSIKSDVWSF 373 Query: 504 GLVLWELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRP 328 G++L E+ S G +PY M+ + + V+ R P CP + +LM CWS P++RP Sbjct: 374 GVLLHEIFSRGQMPYPGMSNHET-FLRVDAGYRMPCPLECPPNIHKLMLSCWSRDPKQRP 432 Query: 327 VFTEIVQTLENL 292 F ++ + L + Sbjct: 433 CFKDLCEKLTGI 444
>EPHA6_HUMAN (Q9UF33) Ephrin type-A receptor 6 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2) Length = 1035 Score = 75.5 bits (184), Expect = 1e-13 Identities = 46/128 (35%), Positives = 62/128 (48%), Gaps = 11/128 (8%) Frame = -1 Query: 642 KVVDFGVAFENVYCNTLEDDPGT----------YRWMAPEMCKRKPYGPKVDVYSFGLVL 493 KV DFG++ LEDDP RW APE + + D +S+G+V+ Sbjct: 812 KVSDFGLS------RVLEDDPEAAYTTTGGKIPIRWTAPEAIAYRKFSSASDAWSYGIVM 865 Query: 492 WELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTE 316 WE++S G PY EM+ Q + + R P CP L QLM CW + RP FT+ Sbjct: 866 WEVMSYGERPYWEMSN-QDVILSIEEGYRLPAPMGCPASLHQLMLHCWQKERNHRPKFTD 924 Query: 315 IVQTLENL 292 IV L+ L Sbjct: 925 IVSFLDKL 932
>KIT_BOVIN (P43481) Mast/stem cell growth factor receptor precursor (EC| 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) Length = 977 Score = 75.5 bits (184), Expect = 1e-13 Identities = 37/92 (40%), Positives = 51/92 (55%), Gaps = 1/92 (1%) Frame = -1 Query: 570 RWMAPEMCKRKPYGPKVDVYSFGLVLWELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPS 394 +WMAPE Y + DV+S+G+ LWEL S GS PY M Y ++ + R + P Sbjct: 835 KWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPE 894 Query: 393 SCPTPLQQLMEQCWSAQPEKRPVFTEIVQTLE 298 P + +M+ CW A P KRP F +IVQ +E Sbjct: 895 HAPAEMYDIMKTCWDADPLKRPTFKQIVQLIE 926
>RON_HUMAN (Q04912) Macrophage-stimulating protein receptor precursor (EC| 2.7.10.1) (MSP receptor) (p185-Ron) (CDw136 antigen) [Contains: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain] Length = 1400 Score = 75.5 bits (184), Expect = 1e-13 Identities = 46/138 (33%), Positives = 70/138 (50%), Gaps = 6/138 (4%) Frame = -1 Query: 642 KVVDFGVA---FENVYCNTLEDDPGTY--RWMAPEMCKRKPYGPKVDVYSFGLVLWELVS 478 KV DFG+A + Y + + +WMA E + + K DV+SFG++LWEL++ Sbjct: 1223 KVADFGLARDILDREYYSVQQHRHARLPVKWMALESLQTYRFTTKSDVWSFGVLLWELLT 1282 Query: 477 -GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIVQTL 301 G+ PY + P + + P P CP L Q+M+QCW A P RP F +V + Sbjct: 1283 RGAPPYRHIDPFDLTHFLAQGRRLP-QPEYCPDSLYQVMQQCWEADPAVRPTFRVLVGEV 1341 Query: 300 ENLKTALDRDGTIEKTPT 247 E + +AL D ++ T Sbjct: 1342 EQIVSALLGDHYVQLPAT 1359
>EPHA8_MOUSE (O09127) Ephrin type-A receptor 8 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) Length = 1004 Score = 75.5 bits (184), Expect = 1e-13 Identities = 50/148 (33%), Positives = 69/148 (46%), Gaps = 14/148 (9%) Frame = -1 Query: 642 KVVDFGVAFENVYCNTLEDDPGT----------YRWMAPEMCKRKPYGPKVDVYSFGLVL 493 KV DFG++ LEDDP RW APE + + DV+SFG+V+ Sbjct: 774 KVSDFGLS------RALEDDPEAAYTTAGGKIPIRWTAPEAIAFRTFSSASDVWSFGVVM 827 Query: 492 WELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTE 316 WE+++ G PY MT Q + V + R P CP L QLM CW +RP F Sbjct: 828 WEVLAYGERPYWNMTN-QDVISSVEEGYRLPAPMGCPRALHQLMLDCWHKDRAQRPRFAH 886 Query: 315 IVQTLENL---KTALDRDGTIEKTPTPS 241 +V L+ L +L T+ + P P+ Sbjct: 887 VVSVLDALVHSPESLRATATVSRCPPPA 914
>FPS_AVISP (P00541) Tyrosine-protein kinase transforming protein Fps (EC| 2.7.10.2) Length = 533 Score = 75.5 bits (184), Expect = 1e-13 Identities = 42/124 (33%), Positives = 66/124 (53%), Gaps = 4/124 (3%) Frame = -1 Query: 660 TQKCCAKVVDFGVAFEN---VYCNTLEDDPGTYRWMAPEMCKRKPYGPKVDVYSFGLVLW 490 T+K K+ DFG++ + VY +T +W APE Y + DV+SFG++LW Sbjct: 403 TEKNTLKISDFGMSRQEEDGVYASTGGMKQIPVKWTAPEALNYGRYSSESDVWSFGILLW 462 Query: 489 ELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEI 313 E S G++PY ++ Q A+ + +R P CP + +LM++CW P +RP F + Sbjct: 463 EAFSLGAVPYANLSNQQTREAI-EQGVRLEPPEQCPEDVYRLMQRCWEYDPRRRPSFGAV 521 Query: 312 VQTL 301 Q L Sbjct: 522 HQDL 525
>KIT_HUMAN (P10721) Mast/stem cell growth factor receptor precursor (EC| 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen) Length = 976 Score = 75.5 bits (184), Expect = 1e-13 Identities = 37/92 (40%), Positives = 51/92 (55%), Gaps = 1/92 (1%) Frame = -1 Query: 570 RWMAPEMCKRKPYGPKVDVYSFGLVLWELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPS 394 +WMAPE Y + DV+S+G+ LWEL S GS PY M Y ++ + R + P Sbjct: 834 KWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPE 893 Query: 393 SCPTPLQQLMEQCWSAQPEKRPVFTEIVQTLE 298 P + +M+ CW A P KRP F +IVQ +E Sbjct: 894 HAPAEMYDIMKTCWDADPLKRPTFKQIVQLIE 925
>KIT_FELCA (Q28889) Mast/stem cell growth factor receptor precursor (EC| 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) Length = 978 Score = 75.5 bits (184), Expect = 1e-13 Identities = 37/92 (40%), Positives = 51/92 (55%), Gaps = 1/92 (1%) Frame = -1 Query: 570 RWMAPEMCKRKPYGPKVDVYSFGLVLWELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPS 394 +WMAPE Y + DV+S+G+ LWEL S GS PY M Y ++ + R + P Sbjct: 835 KWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPE 894 Query: 393 SCPTPLQQLMEQCWSAQPEKRPVFTEIVQTLE 298 P + +M+ CW A P KRP F +IVQ +E Sbjct: 895 HAPAEMYDIMKTCWDADPLKRPTFKQIVQLIE 926
>KIT_CAPHI (Q28317) Mast/stem cell growth factor receptor precursor (EC| 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) Length = 978 Score = 75.5 bits (184), Expect = 1e-13 Identities = 37/92 (40%), Positives = 51/92 (55%), Gaps = 1/92 (1%) Frame = -1 Query: 570 RWMAPEMCKRKPYGPKVDVYSFGLVLWELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPS 394 +WMAPE Y + DV+S+G+ LWEL S GS PY M Y ++ + R + P Sbjct: 836 KWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPE 895 Query: 393 SCPTPLQQLMEQCWSAQPEKRPVFTEIVQTLE 298 P + +M+ CW A P KRP F +IVQ +E Sbjct: 896 HAPAEMYDIMKTCWDADPLKRPTFKQIVQLIE 927
>KIT_CANFA (O97799) Mast/stem cell growth factor receptor precursor (EC| 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) Length = 975 Score = 75.5 bits (184), Expect = 1e-13 Identities = 37/92 (40%), Positives = 51/92 (55%), Gaps = 1/92 (1%) Frame = -1 Query: 570 RWMAPEMCKRKPYGPKVDVYSFGLVLWELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPS 394 +WMAPE Y + DV+S+G+ LWEL S GS PY M Y ++ + R + P Sbjct: 833 KWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPE 892 Query: 393 SCPTPLQQLMEQCWSAQPEKRPVFTEIVQTLE 298 P + +M+ CW A P KRP F +IVQ +E Sbjct: 893 HAPAEMYDIMKTCWDADPLKRPTFKQIVQLIE 924
>CSK_MOUSE (P41241) Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase)| (Protein-tyrosine kinase MPK-2) (p50CSK) Length = 450 Score = 75.5 bits (184), Expect = 1e-13 Identities = 42/121 (34%), Positives = 64/121 (52%), Gaps = 1/121 (0%) Frame = -1 Query: 645 AKVVDFGVAFENVYCNTLEDDPGTYRWMAPEMCKRKPYGPKVDVYSFGLVLWELVS-GSI 469 AKV DFG+ E +T + +W APE + K + K DV+SFG++LWE+ S G + Sbjct: 328 AKVSDFGLTKEA--SSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRV 385 Query: 468 PYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIVQTLENLK 289 PY + PL+ V K + P CP + +M+ C RP F ++ + LE++K Sbjct: 386 PYPRI-PLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCSHLDAATRPTFLQLREQLEHIK 444 Query: 288 T 286 T Sbjct: 445 T 445
>EPHA4_HUMAN (P54764) Ephrin type-A receptor 4 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor SEK) (Receptor protein-tyrosine kinase HEK8) Length = 986 Score = 75.1 bits (183), Expect = 2e-13 Identities = 50/145 (34%), Positives = 68/145 (46%), Gaps = 14/145 (9%) Frame = -1 Query: 642 KVVDFGVAFENVYCNTLEDDPGT----------YRWMAPEMCKRKPYGPKVDVYSFGLVL 493 KV DFG++ LEDDP RW APE + + DV+S+G+V+ Sbjct: 761 KVSDFGMS------RVLEDDPEAAYTTRGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVM 814 Query: 492 WELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTE 316 WE++S G PY +M+ Q + + R P CP L QLM CW + RP F + Sbjct: 815 WEVMSYGERPYWDMSN-QDVIKAIEEGYRLPPPMDCPIALHQLMLDCWQKERSDRPKFGQ 873 Query: 315 IVQTLENL---KTALDRDGTIEKTP 250 IV L+ L +L R GT P Sbjct: 874 IVNMLDKLIRNPNSLKRTGTESSRP 898
>FGFR2_HUMAN (P21802) Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1)| (FGFR-2) (Keratinocyte growth factor receptor 2) (CD332 antigen) Length = 821 Score = 75.1 bits (183), Expect = 2e-13 Identities = 41/134 (30%), Positives = 71/134 (52%), Gaps = 4/134 (2%) Frame = -1 Query: 675 RTFCSTQKCCAKVVDFGVA--FENV-YCNTLEDDPGTYRWMAPEMCKRKPYGPKVDVYSF 505 R T+ K+ DFG+A N+ Y + +WMAPE + Y + DV+SF Sbjct: 630 RNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSF 689 Query: 504 GLVLWELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRP 328 G+++WE+ + G PY + P++ + ++ + R P++C L +M CW A P +RP Sbjct: 690 GVLMWEIFTLGGSPYPGI-PVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRP 748 Query: 327 VFTEIVQTLENLKT 286 F ++V+ L+ + T Sbjct: 749 TFKQLVEDLDRILT 762
>EPHA3_RAT (O08680) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor REK4) (TYRO-4) Length = 984 Score = 75.1 bits (183), Expect = 2e-13 Identities = 47/128 (36%), Positives = 63/128 (49%), Gaps = 11/128 (8%) Frame = -1 Query: 642 KVVDFGVAFENVYCNTLEDDPGT----------YRWMAPEMCKRKPYGPKVDVYSFGLVL 493 KV DFG++ LEDDP RW +PE + + DV+S+G+VL Sbjct: 762 KVSDFGLS------RVLEDDPEAAYTTRGGKIPVRWTSPEATAYRKFTSASDVWSYGIVL 815 Query: 492 WELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTE 316 WE++S G PY EM+ Q V++ R +P CP L QLM CW RP F + Sbjct: 816 WEVMSYGERPYWEMSN-QDVIKAVDEGYRLPLPMDCPAALYQLMLDCWQKDRNNRPKFEQ 874 Query: 315 IVQTLENL 292 IV L+ L Sbjct: 875 IVSILDKL 882
>SRK3_SPOLA (P42689) Tyrosine-protein kinase SRK3 (EC 2.7.10.2) (Fragment)| Length = 334 Score = 75.1 bits (183), Expect = 2e-13 Identities = 45/120 (37%), Positives = 65/120 (54%), Gaps = 4/120 (3%) Frame = -1 Query: 642 KVVDFGVAF---ENVYCNTLEDDPGTYRWMAPEMCKRKPYGPKVDVYSFGLVLWELVS-G 475 KV DFG+A E++Y N E +W APE + K DV+SFG+++ E+V+ G Sbjct: 201 KVADFGLARVIKEDIY-NPREGTKFPIKWTAPEAALYNRFTIKSDVWSFGVLISEIVTHG 259 Query: 474 SIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIVQTLEN 295 +PY MT Q AV ++ R P CP PL ++M CW +P+ RP F + LE+ Sbjct: 260 RMPYPGMTNRQVLEAV-DRGYRMPCPEGCPDPLYKIMLSCWKHEPDDRPTFESLKNLLED 318
>EPHA7_RAT (P54759) Ephrin type-A receptor 7 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) Length = 998 Score = 74.7 bits (182), Expect = 2e-13 Identities = 48/146 (32%), Positives = 72/146 (49%), Gaps = 11/146 (7%) Frame = -1 Query: 642 KVVDFGVAFENVYCNTLEDDPGTY----------RWMAPEMCKRKPYGPKVDVYSFGLVL 493 KV DFG++ +EDDP RW APE + + + DV+S+G+V+ Sbjct: 773 KVSDFGLS------RVIEDDPEAVYTTTGGKIPVRWTAPEAIQYRKFTSASDVWSYGIVM 826 Query: 492 WELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTE 316 WE++S G PY +M+ Q + + R P CP L QLM CW + +RP F + Sbjct: 827 WEVMSYGERPYWDMSN-QDVIKAIEEGYRLPAPMDCPAGLHQLMLDCWQKERAERPKFEQ 885 Query: 315 IVQTLENLKTALDRDGTIEKTPTPSC 238 IV L+ + R+ + KTP +C Sbjct: 886 IVGILDK----MIRNPSSLKTPLGTC 907
>SEA_AVIET (P23049) Tyrosine-protein kinase transforming protein SEA (EC| 2.7.10.2) Length = 370 Score = 74.7 bits (182), Expect = 2e-13 Identities = 47/138 (34%), Positives = 72/138 (52%), Gaps = 6/138 (4%) Frame = -1 Query: 642 KVVDFGVA---FENVYCNTLEDDPGTY--RWMAPEMCKRKPYGPKVDVYSFGLVLWELVS 478 KV DFG+A F Y + + RWMA E + + + K DV+SFG+++WEL++ Sbjct: 201 KVADFGLARDVFGKEYYSIRQHRHAKLPVRWMALESLQTQKFTTKSDVWSFGVLMWELLT 260 Query: 477 -GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIVQTL 301 G+ PY E+ P A ++ P P CP L +M CW+ PE+RP F+ +V L Sbjct: 261 RGASPYPEVDPYDMARYLLRGRRLP-QPQPCPDTLYGVMLSCWAPTPEERPSFSGLVCEL 319 Query: 300 ENLKTALDRDGTIEKTPT 247 E + +L+ + I T Sbjct: 320 ERVLASLEGEHYINMAVT 337
>FPS_FUJSV (P00530) Tyrosine-protein kinase transforming protein FPS (EC| 2.7.10.2) Length = 873 Score = 74.7 bits (182), Expect = 2e-13 Identities = 42/124 (33%), Positives = 66/124 (53%), Gaps = 4/124 (3%) Frame = -1 Query: 660 TQKCCAKVVDFGVAFEN---VYCNTLEDDPGTYRWMAPEMCKRKPYGPKVDVYSFGLVLW 490 T+K K+ DFG++ + VY +T +W APE Y + DV+SFG++LW Sbjct: 743 TEKNTLKISDFGMSRQEEDGVYASTGGMKQIPVKWTAPEALNYGWYSSESDVWSFGILLW 802 Query: 489 ELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEI 313 E S G++PY ++ Q A+ + +R P CP + +LM++CW P +RP F + Sbjct: 803 EAFSLGAVPYANLSNQQTREAI-EQGVRLEPPEQCPEDVYRLMQRCWEYDPHRRPSFGAV 861 Query: 312 VQTL 301 Q L Sbjct: 862 HQDL 865
>KIT_MOUSE (P05532) Mast/stem cell growth factor receptor precursor (EC| 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) Length = 975 Score = 74.7 bits (182), Expect = 2e-13 Identities = 36/92 (39%), Positives = 51/92 (55%), Gaps = 1/92 (1%) Frame = -1 Query: 570 RWMAPEMCKRKPYGPKVDVYSFGLVLWELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPS 394 +WMAPE Y + DV+S+G+ LWEL S GS PY M Y ++ + R + P Sbjct: 832 KWMAPESIFSCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMVSPE 891 Query: 393 SCPTPLQQLMEQCWSAQPEKRPVFTEIVQTLE 298 P + +M+ CW A P KRP F ++VQ +E Sbjct: 892 HAPAEMYDVMKTCWDADPLKRPTFKQVVQLIE 923
>PGFRA_HUMAN (P16234) Alpha platelet-derived growth factor receptor precursor (EC| 2.7.10.1) (PDGF-R-alpha) (CD140a antigen) Length = 1089 Score = 74.7 bits (182), Expect = 2e-13 Identities = 39/121 (32%), Positives = 64/121 (52%), Gaps = 4/121 (3%) Frame = -1 Query: 642 KVVDFGVAFENVYCNTLEDDPGTY---RWMAPEMCKRKPYGPKVDVYSFGLVLWELVS-G 475 K+ DFG+A + ++ + T+ +WMAPE Y DV+S+G++LWE+ S G Sbjct: 833 KICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLG 892 Query: 474 SIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIVQTLEN 295 PY M Y + R P + + ++M +CW+++PEKRP F + + +EN Sbjct: 893 GTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVEN 952 Query: 294 L 292 L Sbjct: 953 L 953
>FER_HUMAN (P16591) Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2)| (p94-FER) (c-FER) Length = 822 Score = 74.7 bits (182), Expect = 2e-13 Identities = 46/126 (36%), Positives = 68/126 (53%), Gaps = 5/126 (3%) Frame = -1 Query: 642 KVVDFGVAFEN---VYCNT-LEDDPGTYRWMAPEMCKRKPYGPKVDVYSFGLVLWELVS- 478 K+ DFG++ + VY ++ L+ P +W APE Y + DV+SFG++LWE S Sbjct: 699 KISDFGMSRQEDGGVYSSSGLKQIP--IKWTAPEALNYGRYSSESDVWSFGILLWETFSL 756 Query: 477 GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIVQTLE 298 G PY MT QA V + R P CP + ++M +CW +PE RP F+E+ + L Sbjct: 757 GVCPYPGMTNQQAREQV-ERGYRMSAPQHCPEDISKIMMKCWDYKPENRPKFSELQKELT 815 Query: 297 NLKTAL 280 +K L Sbjct: 816 IIKRKL 821
>PTK6_HUMAN (Q13882) Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor| kinase) (Tyrosine-protein kinase BRK) Length = 451 Score = 74.7 bits (182), Expect = 2e-13 Identities = 46/120 (38%), Positives = 65/120 (54%), Gaps = 4/120 (3%) Frame = -1 Query: 642 KVVDFGVAF---ENVYCNTLEDDPGTYRWMAPEMCKRKPYGPKVDVYSFGLVLWELVS-G 475 KV DFG+A E+VY + + P Y+W APE R Y K DV+SFG++L E+ S G Sbjct: 327 KVGDFGLARLIKEDVYLSHDHNIP--YKWTAPEALSRGHYSTKSDVWSFGILLHEMFSRG 384 Query: 474 SIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIVQTLEN 295 +PY M+ A+ V+ R P CP + +LM CW PE+RP F + + L + Sbjct: 385 QVPYPGMSN-HEAFLRVDAGYRMPCPLECPPSVHKLMLTCWCRDPEQRPCFKALRERLSS 443
>FGFR1_XENLA (P22182) Fibroblast growth factor receptor 1 precursor (EC 2.7.10.1)| (FGFR-1) Length = 812 Score = 74.3 bits (181), Expect = 3e-13 Identities = 39/132 (29%), Positives = 71/132 (53%), Gaps = 4/132 (3%) Frame = -1 Query: 675 RTFCSTQKCCAKVVDFGVAFENVYCNTLEDDPG---TYRWMAPEMCKRKPYGPKVDVYSF 505 R T+ K+ DFG+A + + + + +WMAPE + Y + DV+SF Sbjct: 621 RNVLVTEDNIMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSF 680 Query: 504 GLVLWELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRP 328 G++LWE+ + G PY + P++ + ++ + R P++C L +M+ CW A P +RP Sbjct: 681 GVLLWEIFTLGGSPYPGV-PMEELFKLLKEGHRMDKPTNCTNELYMMMKDCWHAMPSQRP 739 Query: 327 VFTEIVQTLENL 292 F ++V+ L+ + Sbjct: 740 TFNQLVEDLDRI 751
>EPHA7_HUMAN (Q15375) Ephrin type-A receptor 7 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Receptor protein-tyrosine kinase HEK11) Length = 998 Score = 74.3 bits (181), Expect = 3e-13 Identities = 48/146 (32%), Positives = 71/146 (48%), Gaps = 11/146 (7%) Frame = -1 Query: 642 KVVDFGVAFENVYCNTLEDDPGTY----------RWMAPEMCKRKPYGPKVDVYSFGLVL 493 KV DFG++ +EDDP RW APE + + + DV+S+G+V+ Sbjct: 773 KVSDFGLS------RVIEDDPEAVYTTTGGKIPVRWTAPEAIQYRKFTSASDVWSYGIVM 826 Query: 492 WELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTE 316 WE++S G PY +M+ Q + + R P CP L QLM CW + +RP F + Sbjct: 827 WEVMSYGERPYWDMSN-QDVIKAIEEGYRLPAPMDCPAGLHQLMLDCWQKERAERPKFEQ 885 Query: 315 IVQTLENLKTALDRDGTIEKTPTPSC 238 IV L+ + R+ KTP +C Sbjct: 886 IVGILDK----MIRNPNSLKTPLGTC 907
>MUSK_CHICK (Q8AXY6) Muscle, skeletal receptor tyrosine protein kinase precursor| (EC 2.7.10.1) (Muscle-specific tyrosine protein kinase receptor) (Muscle-specific kinase receptor) (MuSK) Length = 947 Score = 74.3 bits (181), Expect = 3e-13 Identities = 44/121 (36%), Positives = 61/121 (50%), Gaps = 4/121 (3%) Frame = -1 Query: 642 KVVDFGVA---FENVYCNTLEDDPGTYRWMAPEMCKRKPYGPKVDVYSFGLVLWELVS-G 475 K+ DFG++ + Y E+D RWM PE Y + DV+++G+VLWE+ S G Sbjct: 818 KIADFGLSRNMYSADYYKANENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYG 877 Query: 474 SIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIVQTLEN 295 PY M + Y V + N+ P +CP L LM CWS P RP F I + LE Sbjct: 878 MQPYYGMAHEEVIYYVRDGNILSC-PDNCPLELYNLMRLCWSKLPADRPSFASIHRILER 936 Query: 294 L 292 + Sbjct: 937 M 937
>STE20_YEAST (Q03497) Serine/threonine-protein kinase STE20 (EC 2.7.11.1)| Length = 939 Score = 74.3 bits (181), Expect = 3e-13 Identities = 39/113 (34%), Positives = 61/113 (53%), Gaps = 2/113 (1%) Frame = -1 Query: 642 KVVDFGVAFENVYCNTLEDDP-GTYRWMAPEMCKRKPYGPKVDVYSFGLVLWELVSGSIP 466 K+ DFG + N GT WMAPE+ RK YGPKVD++S G+++ E++ G P Sbjct: 754 KLTDFGFCAQINELNLKRTTMVGTPYWMAPEVVSRKEYGPKVDIWSLGIMIIEMIEGEPP 813 Query: 465 YEEMTPLQAAYAVVNKNLRPI-VPSSCPTPLQQLMEQCWSAQPEKRPVFTEIV 310 Y TPL+A Y + + P + + L++ ++ C +PE R TE++ Sbjct: 814 YLNETPLRALYLIATNGTPKLKEPENLSSSLKKFLDWCLCVEPEDRASATELL 866
>EPHA3_MOUSE (P29319) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ETK1) (MEK4) Length = 983 Score = 74.3 bits (181), Expect = 3e-13 Identities = 46/128 (35%), Positives = 62/128 (48%), Gaps = 11/128 (8%) Frame = -1 Query: 642 KVVDFGVAFENVYCNTLEDDPGT----------YRWMAPEMCKRKPYGPKVDVYSFGLVL 493 KV DFG++ LEDDP RW +PE + + DV+S+G+VL Sbjct: 761 KVSDFGLS------RVLEDDPEAAYTTRGGKIPIRWTSPEAMSYRKFTSASDVWSYGIVL 814 Query: 492 WELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTE 316 WE++S G PY +M+ Q V++ R P CP L QLM CW RP F + Sbjct: 815 WEVMSYGERPYSQMSN-QDVIKAVDERYRLPPPMDCPAALYQLMLDCWQKDRNNRPKFEQ 873 Query: 315 IVQTLENL 292 IV L+ L Sbjct: 874 IVSILDKL 881
>FES_FSVST (P00543) Tyrosine-protein kinase transforming protein Fes (EC| 2.7.10.2) Length = 477 Score = 74.3 bits (181), Expect = 3e-13 Identities = 45/128 (35%), Positives = 68/128 (53%), Gaps = 4/128 (3%) Frame = -1 Query: 660 TQKCCAKVVDFGVAFEN---VYCNTLEDDPGTYRWMAPEMCKRKPYGPKVDVYSFGLVLW 490 T+K K+ DFG++ E VY + +W APE Y + DV+SFG++LW Sbjct: 347 TEKNVLKISDFGMSREEADGVYAASGGLRLVPVKWTAPEALNYGRYSSESDVWSFGILLW 406 Query: 489 ELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEI 313 E S G+ PY ++ Q V K R P CP + +LMEQCW+ +P +RP F+ Sbjct: 407 ETFSLGASPYPNLSNQQTR-EFVEKGGRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSAF 465 Query: 312 VQTLENLK 289 Q L++++ Sbjct: 466 YQELQSIR 473
>ARAF_PIG (O19004) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (A-Raf-1) Length = 606 Score = 74.3 bits (181), Expect = 3e-13 Identities = 44/133 (33%), Positives = 75/133 (56%), Gaps = 10/133 (7%) Frame = -1 Query: 642 KVVDFGVAFENVY---CNTLEDDPGTYRWMAPEMCKRK---PYGPKVDVYSFGLVLWELV 481 K+ DFG+A LE G+ WMA E+ + + PY + DVY++G+VL+EL+ Sbjct: 444 KIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELM 503 Query: 480 SGSIPYEEMTPLQAAYAVVNKN-LRPI---VPSSCPTPLQQLMEQCWSAQPEKRPVFTEI 313 +GS+PY + +V + L P + S+CP +++L+ C Q E+RP+F +I Sbjct: 504 TGSLPYSHIGSRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQI 563 Query: 312 VQTLENLKTALDR 274 + T+E L+ +L + Sbjct: 564 LATIELLQRSLPK 576
>FRK_HUMAN (P42685) Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear| tyrosine protein kinase RAK) Length = 505 Score = 74.3 bits (181), Expect = 3e-13 Identities = 42/123 (34%), Positives = 69/123 (56%), Gaps = 7/123 (5%) Frame = -1 Query: 642 KVVDFGVAF------ENVYCNTLEDDPGTYRWMAPEMCKRKPYGPKVDVYSFGLVLWELV 481 KV DFG+A E++Y + + +W APE + + K DV+SFG++L+E++ Sbjct: 369 KVADFGLARVFKVDNEDIY-ESRHEIKLPVKWTAPEAIRSNKFSIKSDVWSFGILLYEII 427 Query: 480 S-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIVQT 304 + G +PY MT Q + +N R PS+CP +M +CW+A+P++RP F + Sbjct: 428 TYGKMPYSGMTGAQVIQMLA-QNYRLPQPSNCPQQFYNIMLECWNAEPKERPTFETLRWK 486 Query: 303 LEN 295 LE+ Sbjct: 487 LED 489
>LCK_HUMAN (P06239) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell-specific protein-tyrosine kinase) Length = 508 Score = 74.3 bits (181), Expect = 3e-13 Identities = 45/125 (36%), Positives = 64/125 (51%), Gaps = 3/125 (2%) Frame = -1 Query: 642 KVVDFGVA--FENVYCNTLEDDPGTYRWMAPEMCKRKPYGPKVDVYSFGLVLWELVS-GS 472 K+ DFG+A E+ E +W APE + K DV+SFG++L E+V+ G Sbjct: 378 KIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGR 437 Query: 471 IPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIVQTLENL 292 IPY MT + + + R + P +CP L QLM CW +PE RP F + LE+ Sbjct: 438 IPYPGMTNPEVIQNL-ERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDF 496 Query: 291 KTALD 277 TA + Sbjct: 497 FTATE 501
>EPHA7_MOUSE (Q61772) Ephrin type-A receptor 7 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Embryonic brain kinase) (EBK) (Developmental kinase 1) (MDK-1) Length = 998 Score = 73.9 bits (180), Expect = 4e-13 Identities = 48/146 (32%), Positives = 71/146 (48%), Gaps = 11/146 (7%) Frame = -1 Query: 642 KVVDFGVAFENVYCNTLEDDPGTY----------RWMAPEMCKRKPYGPKVDVYSFGLVL 493 KV DFG++ +EDDP RW APE + + + DV+S+G+V+ Sbjct: 773 KVSDFGLS------RVIEDDPEAVYTTTGGKIPVRWTAPEAIQYRKFTSASDVWSYGIVM 826 Query: 492 WELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTE 316 WE++S G PY +M+ Q + + R P CP L QLM CW +RP F + Sbjct: 827 WEVMSYGERPYWDMSN-QDVIKAIEEGYRLPAPMDCPAGLHQLMLDCWQKDRAERPKFEQ 885 Query: 315 IVQTLENLKTALDRDGTIEKTPTPSC 238 IV L+ + R+ + KTP +C Sbjct: 886 IVGILDK----MIRNPSSLKTPLGTC 907
>EPHA7_CHICK (O42422) Ephrin type-A receptor 7 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor CEPHA7) (Tyrosine-protein kinase receptor CEK11) Length = 993 Score = 73.9 bits (180), Expect = 4e-13 Identities = 48/146 (32%), Positives = 71/146 (48%), Gaps = 11/146 (7%) Frame = -1 Query: 642 KVVDFGVAFENVYCNTLEDDPGTY----------RWMAPEMCKRKPYGPKVDVYSFGLVL 493 KV DFG++ +EDDP RW APE + + + DV+S+G+V+ Sbjct: 768 KVSDFGLS------RVIEDDPEAVYTTTGGKIPVRWTAPEAIQYRKFTSASDVWSYGIVM 821 Query: 492 WELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTE 316 WE++S G PY +M+ Q + + R P CP L QLM CW + +RP F + Sbjct: 822 WEVMSYGERPYWDMSN-QDVIKAIEEGYRLPAPMDCPAGLHQLMLDCWQKERGERPKFEQ 880 Query: 315 IVQTLENLKTALDRDGTIEKTPTPSC 238 IV L+ + R+ KTP +C Sbjct: 881 IVGILDK----MIRNPNSLKTPLGTC 902
>EPHA4_CHICK (Q07496) Ephrin type-A receptor 4 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor CEK8) Length = 986 Score = 73.9 bits (180), Expect = 4e-13 Identities = 49/146 (33%), Positives = 69/146 (47%), Gaps = 14/146 (9%) Frame = -1 Query: 642 KVVDFGVAFENVYCNTLEDDPGT----------YRWMAPEMCKRKPYGPKVDVYSFGLVL 493 KV DFG++ LEDDP RW APE + + DV+S+G+V+ Sbjct: 761 KVSDFGMS------RVLEDDPEAAYTTRGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVM 814 Query: 492 WELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTE 316 WE++S G PY +M+ Q + + R P CP L QLM CW + RP F + Sbjct: 815 WEVMSYGERPYWDMSN-QDVIKAIEEGYRLPPPMDCPIALHQLMLDCWQKERSDRPKFGQ 873 Query: 315 IVQTLENL---KTALDRDGTIEKTPT 247 IV L+ L +L R G+ P+ Sbjct: 874 IVNMLDKLIRNPNSLKRTGSESSRPS 899
>EPHA3_HUMAN (P29320) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ETK1) (HEK) (HEK4) Length = 983 Score = 73.9 bits (180), Expect = 4e-13 Identities = 47/128 (36%), Positives = 62/128 (48%), Gaps = 11/128 (8%) Frame = -1 Query: 642 KVVDFGVAFENVYCNTLEDDPGT----------YRWMAPEMCKRKPYGPKVDVYSFGLVL 493 KV DFG++ LEDDP RW +PE + + DV+S+G+VL Sbjct: 761 KVSDFGLS------RVLEDDPEAAYTTRGGKIPIRWTSPEAIAYRKFTSASDVWSYGIVL 814 Query: 492 WELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTE 316 WE++S G PY EM+ Q V++ R P CP L QLM CW RP F + Sbjct: 815 WEVMSYGERPYWEMSN-QDVIKAVDEGYRLPPPMDCPAALYQLMLDCWQKDRNNRPKFEQ 873 Query: 315 IVQTLENL 292 IV L+ L Sbjct: 874 IVSILDKL 881
>FGFR2_XENLA (Q03364) Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1)| (FGFR-2) Length = 813 Score = 73.9 bits (180), Expect = 4e-13 Identities = 41/134 (30%), Positives = 71/134 (52%), Gaps = 4/134 (2%) Frame = -1 Query: 675 RTFCSTQKCCAKVVDFGVAFE--NV-YCNTLEDDPGTYRWMAPEMCKRKPYGPKVDVYSF 505 R T+ K+ DFG+A + N+ Y + +WMAPE + Y + DV+SF Sbjct: 620 RNVLVTENNVMKIADFGLARDVNNIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSF 679 Query: 504 GLVLWELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRP 328 G+++WE+ + G PY + P++ + ++ + R P++C L +M CW A P RP Sbjct: 680 GVLMWEIFTLGGSPYPGI-PVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAIPSHRP 738 Query: 327 VFTEIVQTLENLKT 286 F ++V+ L+ + T Sbjct: 739 TFKQLVEDLDRILT 752
>FGFR1_CHICK (P21804) Basic fibroblast growth factor receptor 1 precursor (EC| 2.7.10.1) Length = 819 Score = 73.6 bits (179), Expect = 5e-13 Identities = 40/132 (30%), Positives = 70/132 (53%), Gaps = 4/132 (3%) Frame = -1 Query: 675 RTFCSTQKCCAKVVDFGVAFENVYCNTLEDDPG---TYRWMAPEMCKRKPYGPKVDVYSF 505 R T+ K+ DFG+A + + + + +WMAPE + Y + DV+SF Sbjct: 625 RNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSF 684 Query: 504 GLVLWELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRP 328 G++LWE+ + G PY + P++ + ++ + R PS+C L +M CW A P +RP Sbjct: 685 GVLLWEIFTLGGSPYPGV-PVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRP 743 Query: 327 VFTEIVQTLENL 292 F ++V+ L+ + Sbjct: 744 TFKQLVEDLDRI 755
>EPHA4_MOUSE (Q03137) Ephrin type-A receptor 4 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor SEK) (MPK-3) Length = 986 Score = 73.6 bits (179), Expect = 5e-13 Identities = 49/145 (33%), Positives = 68/145 (46%), Gaps = 14/145 (9%) Frame = -1 Query: 642 KVVDFGVAFENVYCNTLEDDPGT----------YRWMAPEMCKRKPYGPKVDVYSFGLVL 493 KV DFG++ LEDDP RW APE + + DV+S+G+V+ Sbjct: 761 KVSDFGMS------RVLEDDPEAAYTTRGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVM 814 Query: 492 WELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTE 316 WE++S G PY +M+ Q + + R P CP L QLM CW + RP F + Sbjct: 815 WEVMSYGERPYWDMSN-QDVIKAIEEGYRLPPPMDCPIALHQLMLDCWQKERSDRPKFGQ 873 Query: 315 IVQTLENL---KTALDRDGTIEKTP 250 IV L+ L +L R G+ P Sbjct: 874 IVNMLDKLIRNPNSLKRTGSESSRP 898
>FGFR1_MOUSE (P16092) Basic fibroblast growth factor receptor 1 precursor (EC| 2.7.10.1) (FGFR-1) (bFGF-R) (MFR) Length = 822 Score = 73.6 bits (179), Expect = 5e-13 Identities = 40/132 (30%), Positives = 70/132 (53%), Gaps = 4/132 (3%) Frame = -1 Query: 675 RTFCSTQKCCAKVVDFGVAFENVYCNTLEDDPG---TYRWMAPEMCKRKPYGPKVDVYSF 505 R T+ K+ DFG+A + + + + +WMAPE + Y + DV+SF Sbjct: 627 RNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSF 686 Query: 504 GLVLWELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRP 328 G++LWE+ + G PY + P++ + ++ + R PS+C L +M CW A P +RP Sbjct: 687 GVLLWEIFTLGGSPYPGV-PVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRP 745 Query: 327 VFTEIVQTLENL 292 F ++V+ L+ + Sbjct: 746 TFKQLVEDLDRI 757
>FGFR1_HUMAN (P11362) Basic fibroblast growth factor receptor 1 precursor (EC| 2.7.10.1) (FGFR-1) (bFGF-R) (Fms-like tyrosine kinase 2) (c-fgr) (CD331 antigen) Length = 822 Score = 73.6 bits (179), Expect = 5e-13 Identities = 40/132 (30%), Positives = 70/132 (53%), Gaps = 4/132 (3%) Frame = -1 Query: 675 RTFCSTQKCCAKVVDFGVAFENVYCNTLEDDPG---TYRWMAPEMCKRKPYGPKVDVYSF 505 R T+ K+ DFG+A + + + + +WMAPE + Y + DV+SF Sbjct: 627 RNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSF 686 Query: 504 GLVLWELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRP 328 G++LWE+ + G PY + P++ + ++ + R PS+C L +M CW A P +RP Sbjct: 687 GVLLWEIFTLGGSPYPGV-PVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRP 745 Query: 327 VFTEIVQTLENL 292 F ++V+ L+ + Sbjct: 746 TFKQLVEDLDRI 757
>ARAF_HUMAN (P10398) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (A-raf-1) (Proto-oncogene Pks) Length = 606 Score = 73.6 bits (179), Expect = 5e-13 Identities = 44/133 (33%), Positives = 75/133 (56%), Gaps = 10/133 (7%) Frame = -1 Query: 642 KVVDFGVAFENVY---CNTLEDDPGTYRWMAPEMCKRK---PYGPKVDVYSFGLVLWELV 481 K+ DFG+A LE G+ WMA E+ + + PY + DVY++G+VL+EL+ Sbjct: 444 KIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELM 503 Query: 480 SGSIPYEEMTPLQAAYAVVNKN-LRPI---VPSSCPTPLQQLMEQCWSAQPEKRPVFTEI 313 +GS+PY + +V + L P + S+CP +++L+ C Q E+RP+F +I Sbjct: 504 TGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQI 563 Query: 312 VQTLENLKTALDR 274 + T+E L+ +L + Sbjct: 564 LATIELLQRSLPK 576
>KIT_CHICK (Q08156) Mast/stem cell growth factor receptor precursor (EC| 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) Length = 960 Score = 73.2 bits (178), Expect = 7e-13 Identities = 36/92 (39%), Positives = 51/92 (55%), Gaps = 1/92 (1%) Frame = -1 Query: 570 RWMAPEMCKRKPYGPKVDVYSFGLVLWELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPS 394 +WMAPE Y + DV+S+G++LWEL S GS PY M Y ++ + R P Sbjct: 819 KWMAPESIFNCVYTFESDVWSYGILLWELFSLGSSPYPGMPVDSKFYKMIKEGYRMFSPE 878 Query: 393 SCPTPLQQLMEQCWSAQPEKRPVFTEIVQTLE 298 P + +M+ CW A P +RP F +IVQ +E Sbjct: 879 CSPPEMYDIMKSCWDADPLQRPTFKQIVQLIE 910
>EPA4B_XENLA (Q91694) Ephrin type-A receptor 4-B precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor PAG) (Pagliaccio) Length = 985 Score = 73.2 bits (178), Expect = 7e-13 Identities = 52/159 (32%), Positives = 71/159 (44%), Gaps = 19/159 (11%) Frame = -1 Query: 642 KVVDFGVAFENVYCNTLEDDPGT----------YRWMAPEMCKRKPYGPKVDVYSFGLVL 493 KV DFG++ LEDDP RW APE + + DV+S+G+V+ Sbjct: 760 KVSDFGMS------RVLEDDPEAAYTTRGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVM 813 Query: 492 WELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTE 316 WE++S G PY +M+ Q + + R P CP L QLM CW RP F + Sbjct: 814 WEVMSYGERPYWDMSN-QDVIKAIEEGYRLPPPMDCPIALHQLMLDCWQKDRSDRPKFGQ 872 Query: 315 IVQTLENL--------KTALDRDGTIEKTPTPSCQEAAQ 223 IV L+ L +T L+ T PS E +Q Sbjct: 873 IVSMLDKLIRNPNSLKRTGLENSRTNTALLDPSSPEWSQ 911
>PGFRB_MOUSE (P05622) Beta platelet-derived growth factor receptor precursor (EC| 2.7.10.1) (PDGF-R-beta) Length = 1098 Score = 73.2 bits (178), Expect = 7e-13 Identities = 39/121 (32%), Positives = 63/121 (52%), Gaps = 4/121 (3%) Frame = -1 Query: 642 KVVDFGVAFENVYCNTLEDDPGTY---RWMAPEMCKRKPYGPKVDVYSFGLVLWELVS-G 475 K+ DFG+A + + + TY +WMAPE Y DV+SFG++LWE+ + G Sbjct: 840 KICDFGLARDIMRDSNYISKGSTYLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLG 899 Query: 474 SIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIVQTLEN 295 PY E+ Y + + R P+ + ++M++CW + E RP F+++V LE Sbjct: 900 GTPYPELPMNDQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPFSQLVLLLER 959 Query: 294 L 292 L Sbjct: 960 L 960
>EPHB2_MOUSE (P54763) Ephrin type-B receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EPH-3) (Neural kinase) (Nuk receptor tyrosine kinase) (SEK-3) Length = 994 Score = 73.2 bits (178), Expect = 7e-13 Identities = 47/130 (36%), Positives = 66/130 (50%), Gaps = 13/130 (10%) Frame = -1 Query: 642 KVVDFGVAFENVYCNTLEDDPG--TY----------RWMAPEMCKRKPYGPKVDVYSFGL 499 KV DFG++ LEDD TY RW APE + + + DV+S+G+ Sbjct: 769 KVSDFGLS------RFLEDDTSDPTYTSALGGKIPIRWTAPEAIQYRKFTSASDVWSYGI 822 Query: 498 VLWELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVF 322 V+WE++S G PY +MT Q + ++ R P CP+ L QLM CW RP F Sbjct: 823 VMWEVMSYGERPYWDMTN-QDVINAIEQDYRLPPPMDCPSALHQLMLDCWQKDRNHRPKF 881 Query: 321 TEIVQTLENL 292 +IV TL+ + Sbjct: 882 GQIVNTLDKM 891
>EPHB2_HUMAN (P29323) Ephrin type-B receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EPH-3) (DRT) (Receptor protein-tyrosine kinase HEK5) (ERK) (NY-REN-47 antigen) Length = 1055 Score = 73.2 bits (178), Expect = 7e-13 Identities = 47/130 (36%), Positives = 66/130 (50%), Gaps = 13/130 (10%) Frame = -1 Query: 642 KVVDFGVAFENVYCNTLEDDPG--TY----------RWMAPEMCKRKPYGPKVDVYSFGL 499 KV DFG++ LEDD TY RW APE + + + DV+S+G+ Sbjct: 761 KVSDFGLS------RFLEDDTSDPTYTSALGGKIPIRWTAPEAIQYRKFTSASDVWSYGI 814 Query: 498 VLWELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVF 322 V+WE++S G PY +MT Q + ++ R P CP+ L QLM CW RP F Sbjct: 815 VMWEVMSYGERPYWDMTN-QDVINAIEQDYRLPPPMDCPSALHQLMLDCWQKDRNHRPKF 873 Query: 321 TEIVQTLENL 292 +IV TL+ + Sbjct: 874 GQIVNTLDKM 883
>EPHA3_CHICK (P29318) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ETK1) (CEK4) Length = 983 Score = 73.2 bits (178), Expect = 7e-13 Identities = 46/128 (35%), Positives = 61/128 (47%), Gaps = 11/128 (8%) Frame = -1 Query: 642 KVVDFGVAFENVYCNTLEDDPGT----------YRWMAPEMCKRKPYGPKVDVYSFGLVL 493 KV DFG++ LEDDP RW +PE + + D +S+G+VL Sbjct: 761 KVSDFGLS------RVLEDDPEAAYTTRGGKIPIRWTSPEAIAYRKFTSASDAWSYGIVL 814 Query: 492 WELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTE 316 WE++S G PY EM+ Q V++ R P CP L QLM CW RP F + Sbjct: 815 WEVMSYGERPYWEMS-FQDVIKAVDEGYRLPPPMDCPAALYQLMLDCWQKDRNNRPKFEQ 873 Query: 315 IVQTLENL 292 IV L+ L Sbjct: 874 IVSILDKL 881
>ARAF_RAT (P14056) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) Length = 604 Score = 73.2 bits (178), Expect = 7e-13 Identities = 44/133 (33%), Positives = 75/133 (56%), Gaps = 10/133 (7%) Frame = -1 Query: 642 KVVDFGVAFENVY---CNTLEDDPGTYRWMAPEMCKRK---PYGPKVDVYSFGLVLWELV 481 K+ DFG+A LE G+ WMA E+ + + PY + DVY++G+VL+EL+ Sbjct: 442 KIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELM 501 Query: 480 SGSIPYEEMTPLQAAYAVVNKN-LRPIVP---SSCPTPLQQLMEQCWSAQPEKRPVFTEI 313 +GS+PY + +V + L P + S+CP +++L+ C Q E+RP+F +I Sbjct: 502 TGSLPYSHIGSRDQIIFMVGRGYLSPDLSKIFSNCPKAMRRLLTDCLKFQREERPLFPQI 561 Query: 312 VQTLENLKTALDR 274 + T+E L+ +L + Sbjct: 562 LATIELLQRSLPK 574
>ARAF_MOUSE (P04627) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) Length = 604 Score = 73.2 bits (178), Expect = 7e-13 Identities = 44/133 (33%), Positives = 75/133 (56%), Gaps = 10/133 (7%) Frame = -1 Query: 642 KVVDFGVAFENVY---CNTLEDDPGTYRWMAPEMCKRK---PYGPKVDVYSFGLVLWELV 481 K+ DFG+A LE G+ WMA E+ + + PY + DVY++G+VL+EL+ Sbjct: 442 KIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELM 501 Query: 480 SGSIPYEEMTPLQAAYAVVNKN-LRPIVP---SSCPTPLQQLMEQCWSAQPEKRPVFTEI 313 +GS+PY + +V + L P + S+CP +++L+ C Q E+RP+F +I Sbjct: 502 TGSLPYSHIGSRDQIIFMVGRGYLSPDLSKIFSNCPKAMRRLLTDCLKFQREERPLFPQI 561 Query: 312 VQTLENLKTALDR 274 + T+E L+ +L + Sbjct: 562 LATIELLQRSLPK 574
>M3K7_DROME (Q9V3Q6) Mitogen-activated protein kinase kinase kinase 7 (EC| 2.7.11.25) (TGF-beta-activated kinase 1) (dTAK1) Length = 678 Score = 73.2 bits (178), Expect = 7e-13 Identities = 40/131 (30%), Positives = 66/131 (50%), Gaps = 1/131 (0%) Frame = -1 Query: 642 KVVDFGVAFENVYCNTLEDDPGTYRWMAPEMCKRKPYGPKVDVYSFGLVLWELVSGSIPY 463 K+ DFG + + ++ G+ WMAPE+ + Y K D++S+ +VLWE++S P+ Sbjct: 156 KICDFGTVADK--STMMTNNRGSAAWMAPEVFEGSKYTEKCDIFSWAIVLWEVLSRKQPF 213 Query: 462 EEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIVQTL-ENLKT 286 + + + K RP + ++CP ++ LM CW PE RP IV + E +K Sbjct: 214 KGIDNAYTIQWKIYKGERPPLLTTCPKRIEDLMTACWKTVPEDRPSMQYIVGVMHEIVKD 273 Query: 285 ALDRDGTIEKT 253 D +E T Sbjct: 274 YTGADKALEYT 284
>TIE1_BRARE (O73792) Tyrosine-protein kinase receptor Tie-1 (EC 2.7.10.1)| (Fragment) Length = 184 Score = 73.2 bits (178), Expect = 7e-13 Identities = 48/124 (38%), Positives = 68/124 (54%), Gaps = 3/124 (2%) Frame = -1 Query: 645 AKVVDFGVAF-ENVYCN-TLEDDPGTYRWMAPEMCKRKPYGPKVDVYSFGLVLWELVS-G 475 AK+ DFG++ E VY T+ P RWMA E Y K DV+SFG++LWE+VS G Sbjct: 39 AKIADFGLSRGEEVYVKKTMGRLP--VRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLG 96 Query: 474 SIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIVQTLEN 295 PY MT + Y + + R P +C + +LM QCW +P +RP F++I L Sbjct: 97 GTPYCGMTCAE-LYEKLPQGYRMEQPRNCDDEVYELMRQCWRDRPYERPPFSQISVQLNR 155 Query: 294 LKTA 283 ++ A Sbjct: 156 MQEA 159
>EPA4A_BRARE (O13148) Ephrin type-A receptor 4a (EC 2.7.10.1) (Tyrosine-protein| kinase receptor ZEK2) (EPH-like kinase 2) (Fragment) Length = 292 Score = 73.2 bits (178), Expect = 7e-13 Identities = 47/137 (34%), Positives = 67/137 (48%), Gaps = 20/137 (14%) Frame = -1 Query: 642 KVVDFGVAFENVYCNTLEDDP----------GTY---------RWMAPEMCKRKPYGPKV 520 KV DFG++ LE+DP GTY RW APE + + Sbjct: 135 KVSDFGMS------RVLEEDPDAAYTTREITGTYQSQGGKIPIRWTAPEAITYRKFTSAS 188 Query: 519 DVYSFGLVLWELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQ 343 DV+S+G+V+WE++S G PY +M+ Q + + R P CP L QLM CW + Sbjct: 189 DVWSYGIVMWEVMSYGERPYWDMSN-QDVIKAIEEGYRLPPPMDCPVSLHQLMLDCWQKE 247 Query: 342 PEKRPVFTEIVQTLENL 292 +RP F++IV L+ L Sbjct: 248 RAERPKFSQIVNMLDKL 264
>BRAF1_COTJA (P34908) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (RMIL serine/threonine-protein kinase) (c-RMIL) Length = 807 Score = 72.8 bits (177), Expect = 9e-13 Identities = 49/156 (31%), Positives = 81/156 (51%), Gaps = 10/156 (6%) Frame = -1 Query: 642 KVVDFGVAFENVY---CNTLEDDPGTYRWMAPEMCK---RKPYGPKVDVYSFGLVLWELV 481 K+ DFG+A + E G+ WMAPE+ + + PY + DVY+FG+VL+EL+ Sbjct: 631 KIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELM 690 Query: 480 SGSIPYEEMTPL-QAAYAVVNKNLRP---IVPSSCPTPLQQLMEQCWSAQPEKRPVFTEI 313 +G +PY + Q + V L P V S+CP +++LM +C + ++RP+F +I Sbjct: 691 TGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQI 750 Query: 312 VQTLENLKTALDRDGTIEKTPTPSCQEAAQEQNKNR 205 + ++E L +L P +A E + NR Sbjct: 751 LASIELLARSL-----------PKIHRSASEPSLNR 775
>EPHB2_COTJA (Q90344) Ephrin type-B receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor QEK5) Length = 987 Score = 72.8 bits (177), Expect = 9e-13 Identities = 47/130 (36%), Positives = 65/130 (50%), Gaps = 13/130 (10%) Frame = -1 Query: 642 KVVDFGVAFENVYCNTLEDDPG--TY----------RWMAPEMCKRKPYGPKVDVYSFGL 499 KV DFG++ LEDD TY RW APE + + + DV+S+G+ Sbjct: 762 KVSDFGLS------RFLEDDTSDPTYTSALGGKIPIRWTAPEAIQYRKFTSASDVWSYGI 815 Query: 498 VLWELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVF 322 V+WE++S G PY +MT Q + ++ R P CP L QLM CW RP F Sbjct: 816 VMWEVMSYGERPYWDMTN-QDVINAIEQDYRLPPPMDCPNALHQLMLDCWQKDRNHRPKF 874 Query: 321 TEIVQTLENL 292 +IV TL+ + Sbjct: 875 GQIVNTLDKM 884
>EPHB2_CHICK (P28693) Ephrin type-B receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor CEK5) Length = 1004 Score = 72.8 bits (177), Expect = 9e-13 Identities = 47/130 (36%), Positives = 65/130 (50%), Gaps = 13/130 (10%) Frame = -1 Query: 642 KVVDFGVAFENVYCNTLEDDPG--TY----------RWMAPEMCKRKPYGPKVDVYSFGL 499 KV DFG++ LEDD TY RW APE + + + DV+S+G+ Sbjct: 779 KVSDFGLS------RFLEDDTSDPTYTSALGGKIPIRWTAPEAIQYRKFTSASDVWSYGI 832 Query: 498 VLWELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVF 322 V+WE++S G PY +MT Q + ++ R P CP L QLM CW RP F Sbjct: 833 VMWEVMSYGERPYWDMTN-QDVINAIEQDYRLPPPMDCPNALHQLMLDCWQKDRNHRPKF 891 Query: 321 TEIVQTLENL 292 +IV TL+ + Sbjct: 892 GQIVNTLDKM 901
>BRAF1_HUMAN (P15056) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (p94) (v-Raf murine sarcoma viral oncogene homolog B1) Length = 766 Score = 72.8 bits (177), Expect = 9e-13 Identities = 49/156 (31%), Positives = 81/156 (51%), Gaps = 10/156 (6%) Frame = -1 Query: 642 KVVDFGVAFENVY---CNTLEDDPGTYRWMAPEMCK---RKPYGPKVDVYSFGLVLWELV 481 K+ DFG+A + E G+ WMAPE+ + + PY + DVY+FG+VL+EL+ Sbjct: 591 KIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELM 650 Query: 480 SGSIPYEEMTPL-QAAYAVVNKNLRP---IVPSSCPTPLQQLMEQCWSAQPEKRPVFTEI 313 +G +PY + Q + V L P V S+CP +++LM +C + ++RP+F +I Sbjct: 651 TGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQI 710 Query: 312 VQTLENLKTALDRDGTIEKTPTPSCQEAAQEQNKNR 205 + ++E L +L P +A E + NR Sbjct: 711 LASIELLARSL-----------PKIHRSASEPSLNR 735
>YES_XIPHE (P27447) Tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes)| Length = 543 Score = 72.8 bits (177), Expect = 9e-13 Identities = 46/131 (35%), Positives = 66/131 (50%), Gaps = 9/131 (6%) Frame = -1 Query: 642 KVVDFGVAFENVYCNTLEDDPGTYR--------WMAPEMCKRKPYGPKVDVYSFGLVLWE 487 K+ DFG+A +ED+ T R W APE + K DV+SFG++L E Sbjct: 411 KIADFGLA------RLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTE 464 Query: 486 LVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIV 310 LV+ G +PY M + V ++ R P CP L ++M QCW +P++RP F I Sbjct: 465 LVTKGRVPYPGMVNREVLEQV-DRGYRMPCPQGCPESLHEMMRQCWKKEPDERPTFEYIQ 523 Query: 309 QTLENLKTALD 277 LE+ TA + Sbjct: 524 SFLEDYFTATE 534
>BRAF1_MOUSE (P28028) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Fragment) Length = 328 Score = 72.8 bits (177), Expect = 9e-13 Identities = 49/156 (31%), Positives = 81/156 (51%), Gaps = 10/156 (6%) Frame = -1 Query: 642 KVVDFGVAFENVY---CNTLEDDPGTYRWMAPEMCK---RKPYGPKVDVYSFGLVLWELV 481 K+ DFG+A + E G+ WMAPE+ + + PY + DVY+FG+VL+EL+ Sbjct: 153 KIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELM 212 Query: 480 SGSIPYEEMTPL-QAAYAVVNKNLRP---IVPSSCPTPLQQLMEQCWSAQPEKRPVFTEI 313 +G +PY + Q + V L P V S+CP +++LM +C + ++RP+F +I Sbjct: 213 TGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQI 272 Query: 312 VQTLENLKTALDRDGTIEKTPTPSCQEAAQEQNKNR 205 + ++E L +L P +A E + NR Sbjct: 273 LASIELLARSL-----------PKIHRSASEPSLNR 297
>BRAF1_CHICK (Q04982) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Rmil serine/threonine-protein kinase) (c-Rmil) Length = 806 Score = 72.8 bits (177), Expect = 9e-13 Identities = 49/156 (31%), Positives = 81/156 (51%), Gaps = 10/156 (6%) Frame = -1 Query: 642 KVVDFGVAFENVY---CNTLEDDPGTYRWMAPEMCK---RKPYGPKVDVYSFGLVLWELV 481 K+ DFG+A + E G+ WMAPE+ + + PY + DVY+FG+VL+EL+ Sbjct: 631 KIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELM 690 Query: 480 SGSIPYEEMTPL-QAAYAVVNKNLRP---IVPSSCPTPLQQLMEQCWSAQPEKRPVFTEI 313 +G +PY + Q + V L P V S+CP +++LM +C + ++RP+F +I Sbjct: 691 TGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQI 750 Query: 312 VQTLENLKTALDRDGTIEKTPTPSCQEAAQEQNKNR 205 + ++E L +L P +A E + NR Sbjct: 751 LASIELLARSL-----------PKIHRSASEPSLNR 775
>EPA4A_XENLA (Q91845) Ephrin type-A receptor 4-A precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor SEK-1) (xSEK-1) Length = 986 Score = 72.8 bits (177), Expect = 9e-13 Identities = 53/160 (33%), Positives = 72/160 (45%), Gaps = 20/160 (12%) Frame = -1 Query: 642 KVVDFGVAFENVYCNTLEDDPGT----------YRWMAPEMCKRKPYGPKVDVYSFGLVL 493 KV DFG++ LEDDP RW APE + + DV+S+G+V+ Sbjct: 760 KVSDFGMS------RVLEDDPEAAYTTRGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVM 813 Query: 492 WELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTE 316 WE++S G PY +M+ Q + + R P CP L QLM CW + RP F + Sbjct: 814 WEVMSYGERPYWDMSN-QDVIKAIEEGYRLPPPMDCPIALHQLMLDCWQKERSDRPKFGQ 872 Query: 315 IVQTLENL--------KTALDRDGTIEKT-PTPSCQEAAQ 223 IV L+ L +T LD T PS E +Q Sbjct: 873 IVSMLDKLIRNPNSLKRTGLDNSSRTNTTLLDPSSPEWSQ 912
>RMIL_AVII1 (P10533) Serine/threonine-protein kinase transforming protein Rmil| (EC 2.7.11.1) Length = 367 Score = 72.8 bits (177), Expect = 9e-13 Identities = 49/156 (31%), Positives = 81/156 (51%), Gaps = 10/156 (6%) Frame = -1 Query: 642 KVVDFGVAFENVY---CNTLEDDPGTYRWMAPEMCK---RKPYGPKVDVYSFGLVLWELV 481 K+ DFG+A + E G+ WMAPE+ + + PY + DVY+FG+VL+EL+ Sbjct: 201 KIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELM 260 Query: 480 SGSIPYEEMTPL-QAAYAVVNKNLRP---IVPSSCPTPLQQLMEQCWSAQPEKRPVFTEI 313 +G +PY + Q + V L P V S+CP +++LM +C + ++RP+F +I Sbjct: 261 TGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQI 320 Query: 312 VQTLENLKTALDRDGTIEKTPTPSCQEAAQEQNKNR 205 + ++E L +L P +A E + NR Sbjct: 321 LASIELLARSL-----------PKIHRSASEPSLNR 345
>LTK_MOUSE (P08923) Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1)| Length = 888 Score = 72.8 bits (177), Expect = 9e-13 Identities = 49/159 (30%), Positives = 74/159 (46%), Gaps = 5/159 (3%) Frame = -1 Query: 666 CSTQKCCAKVVDFGVAFENVYCNTLEDDPGTY---RWMAPEMCKRKPYGPKVDVYSFGLV 496 CS AK+ DFG+A + + T +WM PE + K D +SFG++ Sbjct: 649 CSGASRVAKIGDFGMARDIYQASYYRKGGRTLLPVKWMPPEALLEGLFTSKTDSWSFGVL 708 Query: 495 LWELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFT 319 LWE+ S G +PY T + + N R P +CP P+ ++M QCW QPE RP F Sbjct: 709 LWEIFSLGYMPYPGHTNQEVLDFIATGN-RMDPPRNCPGPVYRIMTQCWQHQPELRPDFG 767 Query: 318 EIVQTLENLKTALD-RDGTIEKTPTPSCQEAAQEQNKNR 205 I++ ++ D + + P P +E + NR Sbjct: 768 SILERIQYCTQDPDVLNSPLPMEPGPILEEEEASRLGNR 806
>RMIL_AVEVR (P27966) Serine/threonine-protein kinase transforming protein Rmil| (EC 2.7.11.1) Length = 450 Score = 72.8 bits (177), Expect = 9e-13 Identities = 49/156 (31%), Positives = 81/156 (51%), Gaps = 10/156 (6%) Frame = -1 Query: 642 KVVDFGVAFENVY---CNTLEDDPGTYRWMAPEMCK---RKPYGPKVDVYSFGLVLWELV 481 K+ DFG+A + E G+ WMAPE+ + + PY + DVY+FG+VL+EL+ Sbjct: 217 KIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELM 276 Query: 480 SGSIPYEEMTPL-QAAYAVVNKNLRP---IVPSSCPTPLQQLMEQCWSAQPEKRPVFTEI 313 +G +PY + Q + V L P V S+CP +++LM +C + ++RP+F +I Sbjct: 277 TGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQI 336 Query: 312 VQTLENLKTALDRDGTIEKTPTPSCQEAAQEQNKNR 205 + ++E L +L P +A E + NR Sbjct: 337 LASIELLARSL-----------PKIHRSASEPSLNR 361
>MET_HUMAN (P08581) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1390 Score = 72.4 bits (176), Expect = 1e-12 Identities = 43/127 (33%), Positives = 70/127 (55%), Gaps = 8/127 (6%) Frame = -1 Query: 657 QKCCAKVVDFGVA-------FENVYCNTLEDDPGTYRWMAPEMCKRKPYGPKVDVYSFGL 499 +K KV DFG+A + +V+ T P +WMA E + + + K DV+SFG+ Sbjct: 1214 EKFTVKVADFGLARDMYDKEYYSVHNKTGAKLP--VKWMALESLQTQKFTTKSDVWSFGV 1271 Query: 498 VLWELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVF 322 VLWEL++ G+ PY ++ ++ + R + P CP PL ++M +CW + E RP F Sbjct: 1272 VLWELMTRGAPPYPDVNTFDITVYLL-QGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSF 1330 Query: 321 TEIVQTL 301 +E+V + Sbjct: 1331 SELVSRI 1337
>CAD96_DROME (Q9VBW3) Tyrosine kinase receptor Cad96Ca precursor (EC 2.7.10.1)| (Cadherin 96Ca) (Tyrosine kinase receptor HD-14) Length = 773 Score = 72.4 bits (176), Expect = 1e-12 Identities = 44/132 (33%), Positives = 63/132 (47%), Gaps = 4/132 (3%) Frame = -1 Query: 675 RTFCSTQKCCAKVVDFGVAFENVYCNTLE---DDPGTYRWMAPEMCKRKPYGPKVDVYSF 505 R T KV DFG A + + E + RWMA E + K D++SF Sbjct: 614 RNILITDDHTCKVADFGFARDVITSKIYERKSEGKLPIRWMATESLYDNIFSVKSDIWSF 673 Query: 504 GLVLWELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRP 328 G+++WE+V+ GS PY ++ V R P C L +M CWS P++RP Sbjct: 674 GILMWEIVTLGSTPYPGISAADVMRKV-RDGYRLEKPEHCRRELYNIMYYCWSHDPQERP 732 Query: 327 VFTEIVQTLENL 292 +F EI+Q L+ L Sbjct: 733 LFAEIIQMLDKL 744
>HTK7_HYDAT (Q25197) Putative insulin-like peptide receptor precursor (EC| 2.7.10.1) Length = 1477 Score = 72.4 bits (176), Expect = 1e-12 Identities = 46/120 (38%), Positives = 61/120 (50%), Gaps = 4/120 (3%) Frame = -1 Query: 642 KVVDFGVAFENVYCNTLEDDPGTY---RWMAPEMCKRKPYGPKVDVYSFGLVLWELVS-G 475 K+ DFG+A + N D + RWMAPE K + DV+SFG+VLWE+ + Sbjct: 1190 KIGDFGMARDIYERNYYRKDGKSLLPIRWMAPESLKDGIFSTASDVWSFGVVLWEICTLA 1249 Query: 474 SIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIVQTLEN 295 S PY+ T Q V++ N P C L++ M CW P+ RP F EIV LEN Sbjct: 1250 SQPYQGKTNEQVLNFVLS-NGHLDYPEGCDYQLREFMSLCWHRDPKMRPSFLEIVHVLEN 1308
>ALK_HUMAN (Q9UM73) ALK tyrosine kinase receptor precursor (EC 2.7.10.1)| (Anaplastic lymphoma kinase) (CD246 antigen) Length = 1620 Score = 72.0 bits (175), Expect = 2e-12 Identities = 43/121 (35%), Positives = 63/121 (52%), Gaps = 5/121 (4%) Frame = -1 Query: 645 AKVVDFGVAFENVYCNTLEDDPGT----YRWMAPEMCKRKPYGPKVDVYSFGLVLWELVS 478 AK+ DFG+A ++Y + G +WM PE + K D +SFG++LWE+ S Sbjct: 1266 AKIGDFGMA-RDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFS 1324 Query: 477 -GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIVQTL 301 G +PY + Q V R P +CP P+ ++M QCW QPE RP F I++ + Sbjct: 1325 LGYMPYPSKSN-QEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERI 1383 Query: 300 E 298 E Sbjct: 1384 E 1384
>STK_HYDAT (P17713) Tyrosine-protein kinase STK (EC 2.7.10.2) (P57-STK)| Length = 509 Score = 72.0 bits (175), Expect = 2e-12 Identities = 47/125 (37%), Positives = 62/125 (49%), Gaps = 9/125 (7%) Frame = -1 Query: 642 KVVDFGVAFENVYCNTLEDDPGT--------YRWMAPEMCKRKPYGPKVDVYSFGLVLWE 487 KV DFG+A +EDD T +W APE + K DV+SFG+++ E Sbjct: 375 KVADFGLA------RLIEDDEYTAHEGAKFPIKWTAPEAALYNRFTIKSDVWSFGILMAE 428 Query: 486 LVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIV 310 +V+ G IPY MT Q V PI+P CP PL +M Q W+ PE RP F + Sbjct: 429 IVTKGRIPYPGMTNAQTIAEVEKGYRMPIMPG-CPEPLYNIMLQTWNKDPENRPTFDYLQ 487 Query: 309 QTLEN 295 LE+ Sbjct: 488 GVLED 492
>ALK_MOUSE (P97793) ALK tyrosine kinase receptor precursor (EC 2.7.10.1)| (Anaplastic lymphoma kinase) (CD246 antigen) Length = 1621 Score = 72.0 bits (175), Expect = 2e-12 Identities = 43/121 (35%), Positives = 63/121 (52%), Gaps = 5/121 (4%) Frame = -1 Query: 645 AKVVDFGVAFENVYCNTLEDDPGT----YRWMAPEMCKRKPYGPKVDVYSFGLVLWELVS 478 AK+ DFG+A ++Y + G +WM PE + K D +SFG++LWE+ S Sbjct: 1270 AKIGDFGMA-RDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFS 1328 Query: 477 -GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIVQTL 301 G +PY + Q V R P +CP P+ ++M QCW QPE RP F I++ + Sbjct: 1329 LGYMPYPSKSN-QEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERI 1387 Query: 300 E 298 E Sbjct: 1388 E 1388
>YES_AVISY (P00527) Tyrosine-protein kinase transforming protein YES (EC| 2.7.10.2) (Fragment) Length = 528 Score = 71.6 bits (174), Expect = 2e-12 Identities = 47/134 (35%), Positives = 65/134 (48%), Gaps = 9/134 (6%) Frame = -1 Query: 642 KVVDFGVAFENVYCNTLEDDPGTYR--------WMAPEMCKRKPYGPKVDVYSFGLVLWE 487 K+ DFG+A +ED+ T R W APE + K DV+SFG++L E Sbjct: 401 KIADFGLA------RLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTE 454 Query: 486 LVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIV 310 LV+ G +PY M + V + R P CP L +LM+ CW P++RP F I Sbjct: 455 LVTKGRVPYPGMVNREVLEQV-ERGYRMPCPQGCPESLHELMKLCWKKDPDERPTFEYIQ 513 Query: 309 QTLENLKTALDRDG 268 LE+ TA + G Sbjct: 514 SFLEDYFTAAEPSG 527
>PGFRB_RAT (Q05030) Beta platelet-derived growth factor receptor precursor (EC| 2.7.10.1) (PDGF-R-beta) Length = 1097 Score = 71.6 bits (174), Expect = 2e-12 Identities = 38/121 (31%), Positives = 63/121 (52%), Gaps = 4/121 (3%) Frame = -1 Query: 642 KVVDFGVAFENVYCNTLEDDPGTY---RWMAPEMCKRKPYGPKVDVYSFGLVLWELVS-G 475 K+ DFG+A + + + T+ +WMAPE Y DV+SFG++LWE+ + G Sbjct: 840 KICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLG 899 Query: 474 SIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIVQTLEN 295 PY E+ Y + + R P+ + ++M++CW + E RP F+++V LE Sbjct: 900 GTPYPELPMNDQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPFSQLVLLLER 959 Query: 294 L 292 L Sbjct: 960 L 960
>EPB1B_XENLA (Q91736) Ephrin type-B receptor 1-B (EC 2.7.10.1) (Tyrosine-protein| kinase receptor XELK) (Fragment) Length = 902 Score = 71.6 bits (174), Expect = 2e-12 Identities = 46/130 (35%), Positives = 65/130 (50%), Gaps = 13/130 (10%) Frame = -1 Query: 642 KVVDFGVAFENVYCNTLEDDPG--TY----------RWMAPEMCKRKPYGPKVDVYSFGL 499 KV DFG++ L+DD TY RW APE + + + DV+S+G+ Sbjct: 677 KVSDFGLS------RYLQDDTSDPTYTSSLGGKIPVRWTAPEAIRYRKFTSASDVWSYGI 730 Query: 498 VLWELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVF 322 V+WE++S G PY +M+ Q + ++ R P CP L QLM CW RP F Sbjct: 731 VMWEVMSYGERPYWDMSN-QDVINAIEQDYRLPPPMDCPAALHQLMLDCWQKDRNSRPRF 789 Query: 321 TEIVQTLENL 292 EIV TL+ + Sbjct: 790 GEIVNTLDKM 799
>FYN_XIPHE (P27446) Proto-oncogene tyrosine-protein kinase FYN (EC 2.7.10.2)| (P59-FYN) Length = 536 Score = 71.6 bits (174), Expect = 2e-12 Identities = 47/131 (35%), Positives = 64/131 (48%), Gaps = 9/131 (6%) Frame = -1 Query: 642 KVVDFGVAFENVYCNTLEDDPGTYR--------WMAPEMCKRKPYGPKVDVYSFGLVLWE 487 K+ DFG+A +ED+ T R W APE + K DV+SFG++L E Sbjct: 404 KIADFGLA------RLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTE 457 Query: 486 LVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIV 310 LV+ G +PY M + V + R P CP L +LM QCW PE+RP F + Sbjct: 458 LVTKGRVPYPGMNNREVLEQV-ERGYRMPCPQDCPASLHELMLQCWKKDPEERPTFEYLQ 516 Query: 309 QTLENLKTALD 277 LE+ TA + Sbjct: 517 AFLEDYFTATE 527
>PGFRB_HUMAN (P09619) Beta platelet-derived growth factor receptor precursor (EC| 2.7.10.1) (PDGF-R-beta) (CD140b antigen) Length = 1106 Score = 71.6 bits (174), Expect = 2e-12 Identities = 38/121 (31%), Positives = 64/121 (52%), Gaps = 4/121 (3%) Frame = -1 Query: 642 KVVDFGVAFENVYCNTLEDDPGTY---RWMAPEMCKRKPYGPKVDVYSFGLVLWELVS-G 475 K+ DFG+A + + + T+ +WMAPE Y DV+SFG++LWE+ + G Sbjct: 841 KICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLG 900 Query: 474 SIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIVQTLEN 295 PY E+ + Y + + R P+ + ++M++CW + E RP F+++V LE Sbjct: 901 GTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLER 960 Query: 294 L 292 L Sbjct: 961 L 961
>FLK_RAT (P09760) Tyrosine-protein kinase FLK (EC 2.7.10.2) (Fragment)| Length = 323 Score = 71.6 bits (174), Expect = 2e-12 Identities = 44/123 (35%), Positives = 67/123 (54%), Gaps = 5/123 (4%) Frame = -1 Query: 642 KVVDFGVAFEN---VYCNT-LEDDPGTYRWMAPEMCKRKPYGPKVDVYSFGLVLWELVS- 478 K+ DFG++ + VY ++ L+ P +W APE Y + DV+SFG++LWE S Sbjct: 200 KISDFGMSRQEDGGVYSSSGLKQIP--IKWTAPEALNYGRYSSESDVWSFGILLWETFSL 257 Query: 477 GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIVQTLE 298 G PY MT QA V + R P +CP + +M +CW +PE RP F+++ + L Sbjct: 258 GVCPYPGMTNQQAREQV-ERGYRMSAPQNCPEEIFTIMMKCWDYKPENRPKFSDLHKELT 316 Query: 297 NLK 289 +K Sbjct: 317 AIK 319
>ROS_HUMAN (P08922) Proto-oncogene tyrosine-protein kinase ROS precursor (EC| 2.7.10.1) (c-ros-1) Length = 2347 Score = 71.6 bits (174), Expect = 2e-12 Identities = 42/120 (35%), Positives = 63/120 (52%), Gaps = 5/120 (4%) Frame = -1 Query: 642 KVVDFGVA---FENVYCNTLEDDPGTYRWMAPEMCKRKPYGPKVDVYSFGLVLWELVS-G 475 K+ DFG+A ++N Y + RWMAPE + + DV+SFG+++WE+++ G Sbjct: 2099 KIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLG 2158 Query: 474 SIPYEEMTPLQAA-YAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIVQTLE 298 PY + L Y L P P +CP L LM QCW+ +P++RP F I L+ Sbjct: 2159 HQPYPAHSNLDVLNYVQTGGRLEP--PRNCPDDLWNLMTQCWAQEPDQRPTFHRIQNQLQ 2216
>PGFRA_XENLA (P26619) Alpha platelet-derived growth factor receptor precursor (EC| 2.7.10.1) (PDGF-R-alpha) Length = 1087 Score = 71.6 bits (174), Expect = 2e-12 Identities = 39/121 (32%), Positives = 61/121 (50%), Gaps = 4/121 (3%) Frame = -1 Query: 642 KVVDFGVAFENVYCNTLEDDPGTY---RWMAPEMCKRKPYGPKVDVYSFGLVLWELVS-G 475 K+ DFG+A + ++ + T+ +WMAPE Y DV+SFG++LWE+ S G Sbjct: 833 KICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSFGILLWEIFSLG 892 Query: 474 SIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIVQTLEN 295 PY M Y + R P + +M +CW+++PEKRP F + +E+ Sbjct: 893 GTPYPGMIVDSTFYNKIKSGYRMAKPDHATHEVYDIMVKCWNSEPEKRPSFRHLSDIVES 952 Query: 294 L 292 L Sbjct: 953 L 953
>MOS_MOUSE (P00536) Proto-oncogene serine/threonine-protein kinase mos (EC| 2.7.11.1) (c-mos) (Oocyte maturation factor mos) Length = 390 Score = 71.6 bits (174), Expect = 2e-12 Identities = 46/138 (33%), Positives = 69/138 (50%), Gaps = 10/138 (7%) Frame = -1 Query: 663 STQKCCAKVVDFGVAFENVYCNTLEDDP----GTYRWMAPEMCKRKPYGPKVDVYSFGLV 496 S Q C K+ DFG + + + P GTY APE+ K + PK D+YSFG+ Sbjct: 254 SEQDVC-KISDFGCSQKLQVLRCRQASPHHIGGTYTHQAPEILKGEIATPKADIYSFGIT 312 Query: 495 LWELVSGSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPT------PLQQLMEQCWSAQPEK 334 LW++ + +PY P YAVV NLRP + + T LQ +++ CW A+ + Sbjct: 313 LWQMTTREVPYSG-EPQYVQYAVVAYNLRPSLAGAVFTASLTGKTLQNIIQSCWEARALQ 371 Query: 333 RPVFTEIVQTLENLKTAL 280 RP + + L+ + AL Sbjct: 372 RPCAELLQRDLKAFRGAL 389
>PGFRB_CANFA (Q6QNF3) Beta platelet-derived growth factor receptor precursor (EC| 2.7.10.1) (PDGF-R-beta) Length = 1103 Score = 71.6 bits (174), Expect = 2e-12 Identities = 38/121 (31%), Positives = 64/121 (52%), Gaps = 4/121 (3%) Frame = -1 Query: 642 KVVDFGVAFENVYCNTLEDDPGTY---RWMAPEMCKRKPYGPKVDVYSFGLVLWELVS-G 475 K+ DFG+A + + + T+ +WMAPE Y DV+SFG++LWE+ + G Sbjct: 841 KICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLG 900 Query: 474 SIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIVQTLEN 295 PY E+ + Y + + R P+ + ++M++CW + E RP F+++V LE Sbjct: 901 GTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLER 960 Query: 294 L 292 L Sbjct: 961 L 961
>LCK_AOTNA (Q5PXS1) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) Length = 508 Score = 71.6 bits (174), Expect = 2e-12 Identities = 44/125 (35%), Positives = 63/125 (50%), Gaps = 3/125 (2%) Frame = -1 Query: 642 KVVDFGVA--FENVYCNTLEDDPGTYRWMAPEMCKRKPYGPKVDVYSFGLVLWELVS-GS 472 K+ DFG+A E+ E +W APE + K DV+SFG++L E+V+ G Sbjct: 378 KIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGR 437 Query: 471 IPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIVQTLENL 292 IPY MT + + + R + P +CP L LM CW +PE RP F + LE+ Sbjct: 438 IPYPGMTNPEVIQNL-ERGYRMVRPDNCPEELYHLMMLCWKERPEDRPTFDYLRSVLEDF 496 Query: 291 KTALD 277 TA + Sbjct: 497 FTATE 501
>MET_PONPY (Q2IBD8) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1390 Score = 71.2 bits (173), Expect = 3e-12 Identities = 42/127 (33%), Positives = 70/127 (55%), Gaps = 8/127 (6%) Frame = -1 Query: 657 QKCCAKVVDFGVA-------FENVYCNTLEDDPGTYRWMAPEMCKRKPYGPKVDVYSFGL 499 +K KV DFG+A + +V+ T P +WMA E + + + K DV+SFG+ Sbjct: 1214 EKFTVKVADFGLARDMYDKEYYSVHNKTGAKLP--VKWMALESLQTQKFTTKSDVWSFGV 1271 Query: 498 VLWELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVF 322 +LWEL++ G+ PY ++ ++ + R + P CP PL ++M +CW + E RP F Sbjct: 1272 LLWELMTRGAPPYPDVNTFDITVYLL-QGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSF 1330 Query: 321 TEIVQTL 301 +E+V + Sbjct: 1331 SELVSRI 1337
>MET_PANTR (Q2QLF1) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1390 Score = 71.2 bits (173), Expect = 3e-12 Identities = 42/127 (33%), Positives = 70/127 (55%), Gaps = 8/127 (6%) Frame = -1 Query: 657 QKCCAKVVDFGVA-------FENVYCNTLEDDPGTYRWMAPEMCKRKPYGPKVDVYSFGL 499 +K KV DFG+A + +V+ T P +WMA E + + + K DV+SFG+ Sbjct: 1214 EKFTVKVADFGLARDMYDKEYYSVHNKTGAKLP--VKWMALESLQTQKFTTKSDVWSFGV 1271 Query: 498 VLWELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVF 322 +LWEL++ G+ PY ++ ++ + R + P CP PL ++M +CW + E RP F Sbjct: 1272 LLWELMTRGAPPYPDVNTFDITVYLL-QGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSF 1330 Query: 321 TEIVQTL 301 +E+V + Sbjct: 1331 SELVSRI 1337
>INSR_AEDAE (Q93105) Insulin-like receptor precursor (EC 2.7.10.1) (MIR)| [Contains: Insulin-like receptor alpha chain; Insulin-like receptor beta chain] Length = 1390 Score = 71.2 bits (173), Expect = 3e-12 Identities = 42/118 (35%), Positives = 60/118 (50%), Gaps = 4/118 (3%) Frame = -1 Query: 642 KVVDFGVA---FENVYCNTLEDDPGTYRWMAPEMCKRKPYGPKVDVYSFGLVLWELVS-G 475 K+ DFG+ +E Y RWMAPE K + DV+S+G+VLWE+ + Sbjct: 1177 KIGDFGMTRDIYETDYYRKGTKGFLPVRWMAPESLKDGIFSSSSDVFSYGVVLWEMATLA 1236 Query: 474 SIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIVQTL 301 S PY+ +T Q V++ + P +CP L LM +CW +P RP F EI+ L Sbjct: 1237 SQPYQGLTNDQVLRYVIDGGVMER-PENCPDNLYNLMRRCWQHRPTARPTFMEIISEL 1293
>MET_MICMU (Q2QL89) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1382 Score = 71.2 bits (173), Expect = 3e-12 Identities = 42/127 (33%), Positives = 70/127 (55%), Gaps = 8/127 (6%) Frame = -1 Query: 657 QKCCAKVVDFGVA-------FENVYCNTLEDDPGTYRWMAPEMCKRKPYGPKVDVYSFGL 499 +K KV DFG+A + +V+ T P +WMA E + + + K DV+SFG+ Sbjct: 1215 EKFTVKVADFGLARDMYDKEYYSVHNKTGAKLP--VKWMALESLQTQKFTTKSDVWSFGV 1272 Query: 498 VLWELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVF 322 +LWEL++ G+ PY ++ ++ + R + P CP PL ++M +CW + E RP F Sbjct: 1273 LLWELMTRGAPPYPDVNTFDITVYLL-QGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSF 1331 Query: 321 TEIVQTL 301 +E+V + Sbjct: 1332 SELVSRI 1338
>MOS_RAT (P00539) Proto-oncogene serine/threonine-protein kinase mos (EC| 2.7.11.1) (c-mos) (Oocyte maturation factor mos) Length = 339 Score = 71.2 bits (173), Expect = 3e-12 Identities = 45/135 (33%), Positives = 69/135 (51%), Gaps = 8/135 (5%) Frame = -1 Query: 660 TQKCCAKVVDFGVA--FENVYCN-TLEDDPGTYRWMAPEMCKRKPYGPKVDVYSFGLVLW 490 ++K K+ DFG + +++ C +L GTY APE+ K + PK D+YSFG+ LW Sbjct: 205 SEKDVCKISDFGCSQKLQDLRCRPSLHHIGGTYTHQAPELLKGEIATPKADIYSFGITLW 264 Query: 489 ELVSGSIPYEEMTPLQAAYAVVNKNLRP-----IVPSSCPTPLQQLMEQCWSAQPEKRPV 325 ++ + +PY P YAVV NLRP S LQ ++ CW A+ +RP Sbjct: 265 QMTTREVPYSG-EPQYVQYAVVAYNLRPHWQAVFTASLTGKTLQNNVQSCWEARALQRPG 323 Query: 324 FTEIVQTLENLKTAL 280 + + L+ + AL Sbjct: 324 AELLQKDLKAFRGAL 338
>EPHB5_CHICK (Q07497) Ephrin type-B receptor 5 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase CEK9) Length = 1002 Score = 71.2 bits (173), Expect = 3e-12 Identities = 50/148 (33%), Positives = 73/148 (49%), Gaps = 16/148 (10%) Frame = -1 Query: 642 KVVDFGVAFENVYCNTLEDDPG--TY----------RWMAPEMCKRKPYGPKVDVYSFGL 499 KV DFG++ LEDD TY RW APE + + + DV+S+G+ Sbjct: 777 KVSDFGLS------RFLEDDASNPTYTGALGCKIPIRWTAPEAVQYRKFTSSSDVWSYGI 830 Query: 498 VLWELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVF 322 V+WE++S G PY +M+ Q ++++ R P CPT L LM CW +RP F Sbjct: 831 VMWEVMSYGERPYWDMSN-QDVINAIDQDYRLPPPPDCPTVLHLLMLDCWQKDRVQRPKF 889 Query: 321 TEIVQTLENL---KTALDRDGTIEKTPT 247 +IV L+ + +AL GT P+ Sbjct: 890 EQIVSALDKMIRKPSALKATGTGSSRPS 917
>EPHB1_RAT (P09759) Ephrin type-B receptor 1 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EPH-2) (ELK) Length = 984 Score = 71.2 bits (173), Expect = 3e-12 Identities = 46/130 (35%), Positives = 64/130 (49%), Gaps = 13/130 (10%) Frame = -1 Query: 642 KVVDFGVAFENVYCNTLEDDPG--TY----------RWMAPEMCKRKPYGPKVDVYSFGL 499 KV DFG++ L+DD TY RW APE + + DV+S+G+ Sbjct: 759 KVSDFGLS------RYLQDDTSDPTYTSSLGGKIPVRWTAPEAIAYRKFTSASDVWSYGI 812 Query: 498 VLWELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVF 322 V+WE++S G PY +M+ Q + ++ R P CP L QLM CW RP F Sbjct: 813 VMWEVMSFGERPYWDMSN-QDVINAIEQDYRLPPPMDCPAALHQLMLDCWQKDRNSRPRF 871 Query: 321 TEIVQTLENL 292 EIV TL+ + Sbjct: 872 AEIVNTLDKM 881
>EPHB1_HUMAN (P54762) Ephrin type-B receptor 1 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EPH-2) (NET) (HEK6) (ELK) Length = 984 Score = 71.2 bits (173), Expect = 3e-12 Identities = 46/130 (35%), Positives = 64/130 (49%), Gaps = 13/130 (10%) Frame = -1 Query: 642 KVVDFGVAFENVYCNTLEDDPG--TY----------RWMAPEMCKRKPYGPKVDVYSFGL 499 KV DFG++ L+DD TY RW APE + + DV+S+G+ Sbjct: 759 KVSDFGLS------RYLQDDTSDPTYTSSLGGKIPVRWTAPEAIAYRKFTSASDVWSYGI 812 Query: 498 VLWELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVF 322 V+WE++S G PY +M+ Q + ++ R P CP L QLM CW RP F Sbjct: 813 VMWEVMSFGERPYWDMSN-QDVINAIEQDYRLPPPMDCPAALHQLMLDCWQKDRNSRPRF 871 Query: 321 TEIVQTLENL 292 EIV TL+ + Sbjct: 872 AEIVNTLDKM 881
>RYK_HUMAN (P34925) Tyrosine-protein kinase RYK precursor (EC 2.7.10.1)| Length = 604 Score = 71.2 bits (173), Expect = 3e-12 Identities = 37/98 (37%), Positives = 53/98 (54%), Gaps = 1/98 (1%) Frame = -1 Query: 570 RWMAPEMCKRKPYGPKVDVYSFGLVLWELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPS 394 RWMA E + DV++FG+ LWEL++ G PY ++ P + A A + R P Sbjct: 504 RWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPFEMA-AYLKDGYRIAQPI 562 Query: 393 SCPTPLQQLMEQCWSAQPEKRPVFTEIVQTLENLKTAL 280 +CP L +M CW+ PE+RP F ++VQ L AL Sbjct: 563 NCPDELFAVMACCWALDPEERPKFQQLVQCLTEFHAAL 600
>MET_CALMO (Q2QLC0) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1381 Score = 71.2 bits (173), Expect = 3e-12 Identities = 42/127 (33%), Positives = 70/127 (55%), Gaps = 8/127 (6%) Frame = -1 Query: 657 QKCCAKVVDFGVA-------FENVYCNTLEDDPGTYRWMAPEMCKRKPYGPKVDVYSFGL 499 +K KV DFG+A + +V+ T P +WMA E + + + K DV+SFG+ Sbjct: 1214 EKFTVKVADFGLARDMYDKEYYSVHNKTGAKLP--VKWMALESLQTQKFTTKSDVWSFGV 1271 Query: 498 VLWELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVF 322 +LWEL++ G+ PY ++ ++ + R + P CP PL ++M +CW + E RP F Sbjct: 1272 LLWELMTRGAPPYPDVNTFDITVYLL-QGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSF 1330 Query: 321 TEIVQTL 301 +E+V + Sbjct: 1331 SELVSRI 1337
>MET_CALJA (Q2QLG5) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1381 Score = 71.2 bits (173), Expect = 3e-12 Identities = 42/127 (33%), Positives = 70/127 (55%), Gaps = 8/127 (6%) Frame = -1 Query: 657 QKCCAKVVDFGVA-------FENVYCNTLEDDPGTYRWMAPEMCKRKPYGPKVDVYSFGL 499 +K KV DFG+A + +V+ T P +WMA E + + + K DV+SFG+ Sbjct: 1214 EKFTVKVADFGLARDMYDKEYYSVHNKTGAKLP--VKWMALESLQTQKFTTKSDVWSFGV 1271 Query: 498 VLWELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVF 322 +LWEL++ G+ PY ++ ++ + R + P CP PL ++M +CW + E RP F Sbjct: 1272 LLWELMTRGAPPYPDVNTFDITVYLL-QGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSF 1330 Query: 321 TEIVQTL 301 +E+V + Sbjct: 1331 SELVSRI 1337
>FGFR1_RAT (Q04589) Basic fibroblast growth factor receptor 1 precursor (EC| 2.7.10.1) (FGFR-1) (bFGF-R) (MFR) Length = 822 Score = 71.2 bits (173), Expect = 3e-12 Identities = 37/131 (28%), Positives = 67/131 (51%), Gaps = 3/131 (2%) Frame = -1 Query: 675 RTFCSTQKCCAKVVDFGVAFENVYCNTLEDDPG---TYRWMAPEMCKRKPYGPKVDVYSF 505 R T+ K+ DFG+A + + + + +WMAPE + Y + DV+SF Sbjct: 627 RNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSF 686 Query: 504 GLVLWELVSGSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPV 325 G++LWE+ + P++ + ++ + R PS+C L +M CW+A P +RP Sbjct: 687 GVLLWEIFTLGGSPNPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWNAVPSQRPT 746 Query: 324 FTEIVQTLENL 292 F ++V+ L+ + Sbjct: 747 FKQLVEDLDRI 757
>RYK_MOUSE (Q01887) Tyrosine-protein kinase RYK precursor (EC 2.7.10.1)| (Kinase VIK) (NYK-R) (Met-related kinase) Length = 594 Score = 71.2 bits (173), Expect = 3e-12 Identities = 37/98 (37%), Positives = 53/98 (54%), Gaps = 1/98 (1%) Frame = -1 Query: 570 RWMAPEMCKRKPYGPKVDVYSFGLVLWELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPS 394 RWMA E + DV++FG+ LWEL++ G PY ++ P + A A + R P Sbjct: 494 RWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPFEMA-AYLKDGYRIAQPI 552 Query: 393 SCPTPLQQLMEQCWSAQPEKRPVFTEIVQTLENLKTAL 280 +CP L +M CW+ PE+RP F ++VQ L AL Sbjct: 553 NCPDELFAVMACCWALDPEERPKFQQLVQCLTEFHAAL 590
>FGFR2_DROME (Q09147) Fibroblast growth factor receptor homolog 2 precursor (EC| 2.7.10.1) (Protein breathless) (dFGF-R1) Length = 1052 Score = 70.9 bits (172), Expect = 3e-12 Identities = 36/121 (29%), Positives = 63/121 (52%), Gaps = 4/121 (3%) Frame = -1 Query: 642 KVVDFGVAFE---NVYCNTLEDDPGTYRWMAPEMCKRKPYGPKVDVYSFGLVLWELVS-G 475 K+ DFG+A + Y + +WMAPE + K Y + DV+S+G++LWE+++ G Sbjct: 879 KIADFGLARDIQDTEYYRKNTNGRLPIKWMAPESLQEKKYDSQSDVWSYGVLLWEIMTYG 938 Query: 474 SIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIVQTLEN 295 PY + + Y+ + R P+ C + +M QCW + RP F E+V++ + Sbjct: 939 DQPYPHILSAEELYSYLITGQRMEKPAKCSLNIYVVMRQCWHFESCARPTFAELVESFDG 998 Query: 294 L 292 + Sbjct: 999 I 999
>VGFR1_RAT (P53767) Vascular endothelial growth factor receptor 1 precursor (EC| 2.7.10.1) (VEGFR-1) (Tyrosine-protein kinase receptor FLT) (FLT-1) Length = 1336 Score = 70.9 bits (172), Expect = 3e-12 Identities = 46/142 (32%), Positives = 72/142 (50%), Gaps = 6/142 (4%) Frame = -1 Query: 675 RTFCSTQKCCAKVVDFGVAFENVYCNTLEDDPGTYR----WMAPEMCKRKPYGPKVDVYS 508 R ++ K+ DFG+A ++Y N G R WMAPE K Y K DV+S Sbjct: 1026 RNILLSENNVVKICDFGLA-RDIYKNPDYVRRGDTRLPLKWMAPESIFDKVYSTKSDVWS 1084 Query: 507 FGLVLWELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKR 331 +G++LWE+ S G PY + + + + + +R P + Q+M CW P++R Sbjct: 1085 YGVLLWEIFSLGGSPYPGVQMDEDFCSRLKEGMRMRTPEYATPEIYQIMLDCWHKDPKER 1144 Query: 330 PVFTEIVQTLENLKTA-LDRDG 268 P F E+V+ L +L A + +DG Sbjct: 1145 PRFAELVEKLGDLLQANVQQDG 1166
>TIE1_HUMAN (P35590) Tyrosine-protein kinase receptor Tie-1 precursor (EC| 2.7.10.1) Length = 1138 Score = 70.9 bits (172), Expect = 3e-12 Identities = 47/128 (36%), Positives = 67/128 (52%), Gaps = 3/128 (2%) Frame = -1 Query: 657 QKCCAKVVDFGVAF-ENVYCN-TLEDDPGTYRWMAPEMCKRKPYGPKVDVYSFGLVLWEL 484 + +K+ DFG++ E VY T+ P RWMA E Y K DV+SFG++LWE+ Sbjct: 989 ENLASKIADFGLSRGEEVYVKKTMGRLP--VRWMAIESLNYSVYTTKSDVWSFGVLLWEI 1046 Query: 483 VS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIVQ 307 VS G PY MT + Y + + R P +C + +LM QCW +P +RP F +I Sbjct: 1047 VSLGGTPYCGMTCAE-LYEKLPQGYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIAL 1105 Query: 306 TLENLKTA 283 L + A Sbjct: 1106 QLGRMLEA 1113
>VGFR1_MOUSE (P35969) Vascular endothelial growth factor receptor 1 precursor (EC| 2.7.10.1) (VEGFR-1) (Tyrosine-protein kinase receptor FLT) (FLT-1) (Embryonic receptor kinase 2) Length = 1333 Score = 70.9 bits (172), Expect = 3e-12 Identities = 46/142 (32%), Positives = 72/142 (50%), Gaps = 6/142 (4%) Frame = -1 Query: 675 RTFCSTQKCCAKVVDFGVAFENVYCNTLEDDPGTYR----WMAPEMCKRKPYGPKVDVYS 508 R ++ K+ DFG+A ++Y N G R WMAPE K Y K DV+S Sbjct: 1026 RNILLSENNVVKICDFGLA-RDIYKNPDYVRRGDTRLPLKWMAPESIFDKVYSTKSDVWS 1084 Query: 507 FGLVLWELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKR 331 +G++LWE+ S G PY + + + + + +R P + Q+M CW P++R Sbjct: 1085 YGVLLWEIFSLGGSPYPGVQMDEDFCSRLKEGMRMRTPEYATPEIYQIMLDCWHKDPKER 1144 Query: 330 PVFTEIVQTLENLKTA-LDRDG 268 P F E+V+ L +L A + +DG Sbjct: 1145 PRFAELVEKLGDLLQANVQQDG 1166
>HCK_HUMAN (P08631) Tyrosine-protein kinase HCK (EC 2.7.10.2)| (p59-HCK/p60-HCK) (Hemopoietic cell kinase) Length = 525 Score = 70.9 bits (172), Expect = 3e-12 Identities = 45/131 (34%), Positives = 67/131 (51%), Gaps = 9/131 (6%) Frame = -1 Query: 642 KVVDFGVAFENVYCNTLEDDPGTYR--------WMAPEMCKRKPYGPKVDVYSFGLVLWE 487 K+ DFG+A +ED+ T R W APE + K DV+SFG++L E Sbjct: 395 KIADFGLA------RVIEDNEYTAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLME 448 Query: 486 LVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIV 310 +V+ G IPY M+ + A+ + R P +CP L +M +CW +PE+RP F I Sbjct: 449 IVTYGRIPYPGMSNPEVIRAL-ERGYRMPRPENCPEELYNIMMRCWKNRPEERPTFEYIQ 507 Query: 309 QTLENLKTALD 277 L++ TA + Sbjct: 508 SVLDDFYTATE 518
>TIE1_MOUSE (Q06806) Tyrosine-protein kinase receptor Tie-1 precursor (EC| 2.7.10.1) Length = 1134 Score = 70.9 bits (172), Expect = 3e-12 Identities = 47/128 (36%), Positives = 67/128 (52%), Gaps = 3/128 (2%) Frame = -1 Query: 657 QKCCAKVVDFGVAF-ENVYCN-TLEDDPGTYRWMAPEMCKRKPYGPKVDVYSFGLVLWEL 484 + +K+ DFG++ E VY T+ P RWMA E Y K DV+SFG++LWE+ Sbjct: 985 ENLASKIADFGLSRGEEVYVKKTMGRLP--VRWMAIESLNYSVYTTKSDVWSFGVLLWEI 1042 Query: 483 VS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIVQ 307 VS G PY MT + Y + + R P +C + +LM QCW +P +RP F +I Sbjct: 1043 VSLGGTPYCGMTCAE-LYEKLPQGYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIAL 1101 Query: 306 TLENLKTA 283 L + A Sbjct: 1102 QLGRMLEA 1109
>MET_PIG (Q2QLE0) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1381 Score = 70.9 bits (172), Expect = 3e-12 Identities = 42/126 (33%), Positives = 71/126 (56%), Gaps = 7/126 (5%) Frame = -1 Query: 657 QKCCAKVVDFGVAFENVYCN---TLEDDPGT---YRWMAPEMCKRKPYGPKVDVYSFGLV 496 +K KV DFG+A +VY ++ + G +WMA E + + + K DV+SFG++ Sbjct: 1214 EKFTVKVADFGLA-RDVYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVL 1272 Query: 495 LWELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFT 319 LWEL++ G+ PY ++ ++ + R + P CP PL ++M +CW + E RP F+ Sbjct: 1273 LWELMTRGAPPYPDVNTFDITVYLL-QGRRLLQPEYCPDPLYEVMLKCWHPRAELRPSFS 1331 Query: 318 EIVQTL 301 E+V + Sbjct: 1332 ELVSRI 1337
>MET_HORSE (Q2QLA9) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1381 Score = 70.9 bits (172), Expect = 3e-12 Identities = 42/127 (33%), Positives = 70/127 (55%), Gaps = 8/127 (6%) Frame = -1 Query: 657 QKCCAKVVDFGVA-------FENVYCNTLEDDPGTYRWMAPEMCKRKPYGPKVDVYSFGL 499 +K KV DFG+A + +V+ T P +WMA E + + + K DV+SFG+ Sbjct: 1214 EKFTVKVADFGLARDMYDKEYYSVHNKTGAKLP--VKWMALESLQTQKFTTKSDVWSFGV 1271 Query: 498 VLWELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVF 322 +LWEL++ G+ PY ++ ++ + R + P CP PL ++M +CW + E RP F Sbjct: 1272 LLWELMTRGAPPYPDVNTFDITVYLL-QGRRLLQPEYCPDPLYEVMLKCWHPKAELRPSF 1330 Query: 321 TEIVQTL 301 +E+V + Sbjct: 1331 SELVSRI 1337
>YRK_CHICK (Q02977) Proto-oncogene tyrosine-protein kinase Yrk (EC 2.7.10.2)| (p60-Yrk) (Yes-related kinase) Length = 535 Score = 70.9 bits (172), Expect = 3e-12 Identities = 46/131 (35%), Positives = 64/131 (48%), Gaps = 9/131 (6%) Frame = -1 Query: 642 KVVDFGVAFENVYCNTLEDDPGTYR--------WMAPEMCKRKPYGPKVDVYSFGLVLWE 487 K+ DFG+A +ED+ T R W APE + K DV+SFG++L E Sbjct: 403 KIADFGLA------RLIEDNEYTARQGAKFPIKWTAPEAALFGKFTIKSDVWSFGILLTE 456 Query: 486 LVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIV 310 LV+ G +PY M + V + R P CP L +M QCW +PE+RP F + Sbjct: 457 LVTKGRVPYPGMNNREVLEQV-ERGYRMQCPGGCPPSLHDVMVQCWKREPEERPTFEYLQ 515 Query: 309 QTLENLKTALD 277 LE+ TA + Sbjct: 516 SFLEDYFTATE 526
>MET_CANFA (Q75ZY9) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1382 Score = 70.9 bits (172), Expect = 3e-12 Identities = 42/127 (33%), Positives = 70/127 (55%), Gaps = 8/127 (6%) Frame = -1 Query: 657 QKCCAKVVDFGVA-------FENVYCNTLEDDPGTYRWMAPEMCKRKPYGPKVDVYSFGL 499 +K KV DFG+A + +V+ T P +WMA E + + + K DV+SFG+ Sbjct: 1215 EKFTVKVADFGLARDMYDKEYYSVHNKTGAKLP--VKWMALESLQTQKFTTKSDVWSFGV 1272 Query: 498 VLWELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVF 322 +LWEL++ G+ PY ++ ++ + R + P CP PL ++M +CW + E RP F Sbjct: 1273 LLWELMTRGAPPYPDVNTFDITVYLL-QGRRLLQPEYCPDPLYEVMLKCWHPRAELRPSF 1331 Query: 321 TEIVQTL 301 +E+V + Sbjct: 1332 SELVSRI 1338
>MOS_MSVMH (P07331) Serine/threonine-protein kinase transforming protein mos| (EC 2.7.11.1) Length = 374 Score = 70.5 bits (171), Expect = 4e-12 Identities = 46/138 (33%), Positives = 70/138 (50%), Gaps = 10/138 (7%) Frame = -1 Query: 663 STQKCCAKVVDFGVA--FENVYCNTLEDDP--GTYRWMAPEMCKRKPYGPKVDVYSFGLV 496 S Q C K+ DFG + +++ C GTY APE+ K + PK D+YSFG+ Sbjct: 238 SEQDVC-KISDFGCSQKLQDLRCRQASPHHIGGTYTHQAPEILKGEIATPKADIYSFGIT 296 Query: 495 LWELVSGSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPT------PLQQLMEQCWSAQPEK 334 LW++ + +PY P YAVV NLRP + + T LQ +++ CW A+ + Sbjct: 297 LWQMTTREVPYSG-EPQYVQYAVVAYNLRPSLAGAVFTASLTGKTLQNIIQSCWEARALQ 355 Query: 333 RPVFTEIVQTLENLKTAL 280 RP + + L+ + AL Sbjct: 356 RPGAELLQRDLKAFRGAL 373
>LTK_HUMAN (P29376) Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1)| (Protein tyrosine kinase 1) Length = 864 Score = 70.5 bits (171), Expect = 4e-12 Identities = 43/127 (33%), Positives = 63/127 (49%), Gaps = 4/127 (3%) Frame = -1 Query: 666 CSTQKCCAKVVDFGVA---FENVYCNTLEDDPGTYRWMAPEMCKRKPYGPKVDVYSFGLV 496 C+ AK+ DFG+A + Y + +WM PE + K D +SFG++ Sbjct: 653 CAGPSRVAKIGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVL 712 Query: 495 LWELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFT 319 LWE+ S G +PY T + VV R P CP P+ ++M QCW +PE RP F Sbjct: 713 LWEIFSLGYMPYPGRTNQEVLDFVVGGG-RMDPPRGCPGPVYRIMTQCWQHEPELRPSFA 771 Query: 318 EIVQTLE 298 I++ L+ Sbjct: 772 SILERLQ 778
>INSRR_CAVPO (P14617) Insulin receptor-related protein precursor (EC 2.7.10.1)| (IRR) (IR-related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain] Length = 1300 Score = 70.5 bits (171), Expect = 4e-12 Identities = 42/125 (33%), Positives = 64/125 (51%), Gaps = 4/125 (3%) Frame = -1 Query: 660 TQKCCAKVVDFGVA---FENVYCNTLEDDPGTYRWMAPEMCKRKPYGPKVDVYSFGLVLW 490 +Q K+ DFG+ +E Y RWMAPE K + DV+SFG+VLW Sbjct: 1124 SQDFTVKIGDFGMTRDVYETDYYRKGGKGLLPVRWMAPESLKDGIFTTHSDVWSFGVVLW 1183 Query: 489 ELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEI 313 E+V+ PY+ ++ Q V++ + + CP LQ+LM CW P RP FT+I Sbjct: 1184 EIVTLAEQPYQGLSNEQVLKFVMDGGVLEEL-EDCPHQLQELMSSCWQQNPRLRPTFTQI 1242 Query: 312 VQTLE 298 + +++ Sbjct: 1243 LNSIQ 1247
>VGFR3_HUMAN (P35916) Vascular endothelial growth factor receptor 3 precursor (EC| 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4) Length = 1298 Score = 70.5 bits (171), Expect = 4e-12 Identities = 46/170 (27%), Positives = 83/170 (48%), Gaps = 5/170 (2%) Frame = -1 Query: 675 RTFCSTQKCCAKVVDFGVAFENVYCNTLEDDPGTYR----WMAPEMCKRKPYGPKVDVYS 508 R ++ K+ DFG+A ++Y + G+ R WMAPE K Y + DV+S Sbjct: 1041 RNILLSESDVVKICDFGLA-RDIYKDPDYVRKGSARLPLKWMAPESIFDKVYTTQSDVWS 1099 Query: 507 FGLVLWELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKR 331 FG++LWE+ S G+ PY + + + R P ++++M CWS P+ R Sbjct: 1100 FGVLLWEIFSLGASPYPGVQINEEFCQRLRDGTRMRAPELATPAIRRIMLNCWSGDPKAR 1159 Query: 330 PVFTEIVQTLENLKTALDRDGTIEKTPTPSCQEAAQEQNKNRLASWILKL 181 P F+E+V+ L +L E P ++++E + +++++ L + Sbjct: 1160 PAFSELVEILGDLLQGRGLQEEEEVCMAPRSSQSSEEGSFSQVSTMALHI 1209
>VGFR1_HUMAN (P17948) Vascular endothelial growth factor receptor 1 precursor (EC| 2.7.10.1) (VEGFR-1) (Vascular permeability factor receptor) (Tyrosine-protein kinase receptor FLT) (Flt-1) (Tyrosine-protein kinase FRT) (Fms-like tyrosine kinase 1) Length = 1338 Score = 70.5 bits (171), Expect = 4e-12 Identities = 46/142 (32%), Positives = 72/142 (50%), Gaps = 6/142 (4%) Frame = -1 Query: 675 RTFCSTQKCCAKVVDFGVAFENVYCNTLEDDPGTYR----WMAPEMCKRKPYGPKVDVYS 508 R ++ K+ DFG+A ++Y N G R WMAPE K Y K DV+S Sbjct: 1026 RNILLSENNVVKICDFGLA-RDIYKNPDYVRKGDTRLPLKWMAPESIFDKIYSTKSDVWS 1084 Query: 507 FGLVLWELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKR 331 +G++LWE+ S G PY + + + + + +R P + Q+M CW P++R Sbjct: 1085 YGVLLWEIFSLGGSPYPGVQMDEDFCSRLREGMRMRAPEYSTPEIYQIMLDCWHRDPKER 1144 Query: 330 PVFTEIVQTLENLKTA-LDRDG 268 P F E+V+ L +L A + +DG Sbjct: 1145 PRFAELVEKLGDLLQANVQQDG 1166
>TXK_MOUSE (P42682) Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18)| (Resting lymphocyte kinase) Length = 527 Score = 70.5 bits (171), Expect = 4e-12 Identities = 37/123 (30%), Positives = 63/123 (51%), Gaps = 3/123 (2%) Frame = -1 Query: 651 CCAKVVDFGVAFENVYCNTLEDDPGTY--RWMAPEMCKRKPYGPKVDVYSFGLVLWELVS 478 C K+ DFG+A + + + +W PE+ Y K DV+SFG+++WE+ + Sbjct: 402 CVVKISDFGMARYVLDDEYISSSGAKFPVKWCPPEVFHFNKYSSKSDVWSFGVLMWEVFT 461 Query: 477 -GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIVQTL 301 G +P+E + LQ A+ ++ R P P + ++M CW P+ RP F E++Q L Sbjct: 462 EGKMPFENKSNLQVVEAI-SQGFRLYRPHLAPMTIYRVMYSCWHESPKGRPTFAELLQVL 520 Query: 300 ENL 292 + Sbjct: 521 TEI 523
>LCK_MOUSE (P06240) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) Length = 508 Score = 70.5 bits (171), Expect = 4e-12 Identities = 43/125 (34%), Positives = 63/125 (50%), Gaps = 3/125 (2%) Frame = -1 Query: 642 KVVDFGVA--FENVYCNTLEDDPGTYRWMAPEMCKRKPYGPKVDVYSFGLVLWELVS-GS 472 K+ DFG+A E+ E +W APE + K DV+SFG++L E+V+ G Sbjct: 378 KIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGR 437 Query: 471 IPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIVQTLENL 292 IPY MT + + + R + P +CP L LM CW +PE RP F + L++ Sbjct: 438 IPYPGMTNPEVIQNL-ERGYRMVRPDNCPEELYHLMMLCWKERPEDRPTFDYLRSVLDDF 496 Query: 291 KTALD 277 TA + Sbjct: 497 FTATE 501
>FPS_DROME (P18106) Tyrosine-protein kinase Fps85D (EC 2.7.10.2) (dFer)| Length = 1325 Score = 70.1 bits (170), Expect = 6e-12 Identities = 43/126 (34%), Positives = 65/126 (51%), Gaps = 4/126 (3%) Frame = -1 Query: 642 KVVDFGVAFEN---VYCNTLEDDPGTYRWMAPEMCKRKPYGPKVDVYSFGLVLWELVS-G 475 K+ DFG++ E + + ++ P +W APE Y DV+S+G+++WE+ S G Sbjct: 1200 KISDFGMSREEEEYIVSDGMKQIP--VKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKG 1257 Query: 474 SIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIVQTLEN 295 PY MT +A + + R P S P + +LM QCW+A E RP F EI ++ Sbjct: 1258 DTPYSGMTNSRARERI-DTGYRMPTPKSTPEEMYRLMLQCWAADAESRPHFDEIYNVVDA 1316 Query: 294 LKTALD 277 L LD Sbjct: 1317 LILRLD 1322
>LCK_SAISC (Q95KR7) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) Length = 508 Score = 70.1 bits (170), Expect = 6e-12 Identities = 43/125 (34%), Positives = 64/125 (51%), Gaps = 3/125 (2%) Frame = -1 Query: 642 KVVDFGVA--FENVYCNTLEDDPGTYRWMAPEMCKRKPYGPKVDVYSFGLVLWELVS-GS 472 K+ DFG+A E+ E +W APE + K DV+SFG+++ E+V+ G Sbjct: 378 KIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILMTEIVTHGR 437 Query: 471 IPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIVQTLENL 292 IPY MT + + + R P +CP L +LM QCW +P+ RP F + LE+ Sbjct: 438 IPYPGMTNPEVIQNL-ERGYRMPRPDNCPEELYKLMMQCWRERPDDRPTFDYLRSVLEDF 496 Query: 291 KTALD 277 TA + Sbjct: 497 FTATE 501
>IGF1R_XENLA (O73798) Insulin-like growth factor 1 receptor precursor (EC| 2.7.10.1) (xIGF-1R) (xIGFR) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain] Length = 1358 Score = 70.1 bits (170), Expect = 6e-12 Identities = 42/126 (33%), Positives = 63/126 (50%), Gaps = 4/126 (3%) Frame = -1 Query: 660 TQKCCAKVVDFGVA---FENVYCNTLEDDPGTYRWMAPEMCKRKPYGPKVDVYSFGLVLW 490 T+ K+ DFG+ +E Y RWM+PE K + DV+SFG+VLW Sbjct: 1140 TEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTNSDVWSFGVVLW 1199 Query: 489 ELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEI 313 E+ + PY+ M+ Q V+ L P +CP L +LM CW P+ RP F EI Sbjct: 1200 EIATLAEQPYQGMSNEQVLRFVMEGGLLE-KPDNCPDMLFELMRMCWQFNPKMRPSFLEI 1258 Query: 312 VQTLEN 295 + ++++ Sbjct: 1259 ISSIKD 1264
>MOS_MSVMM (P00537) Serine/threonine-protein kinase transforming protein mos| (EC 2.7.11.1) Length = 376 Score = 70.1 bits (170), Expect = 6e-12 Identities = 45/139 (32%), Positives = 71/139 (51%), Gaps = 10/139 (7%) Frame = -1 Query: 663 STQKCCAKVVDFGVA--FENVYCNTLEDDP--GTYRWMAPEMCKRKPYGPKVDVYSFGLV 496 S Q C K+ DFG + +++ C GTY APE+ K + PK D+YSFG+ Sbjct: 238 SEQDVC-KISDFGCSQKLQDLRCRQASPHHIGGTYTHQAPEILKGEIATPKADIYSFGIT 296 Query: 495 LWELVSGSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPT------PLQQLMEQCWSAQPEK 334 LW++ + +PY P YAVV NLRP + + T LQ +++ CW A+ + Sbjct: 297 LWQMTTREVPYSG-EPQYVQYAVVAYNLRPSLAGAVFTASLTGKTLQNIIQSCWEARALQ 355 Query: 333 RPVFTEIVQTLENLKTALD 277 RP + + L+ L +++ Sbjct: 356 RPGAELLQRDLKALADSIE 374
>YES_CHICK (P09324) Tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes)| Length = 540 Score = 70.1 bits (170), Expect = 6e-12 Identities = 46/131 (35%), Positives = 64/131 (48%), Gaps = 9/131 (6%) Frame = -1 Query: 642 KVVDFGVAFENVYCNTLEDDPGTYR--------WMAPEMCKRKPYGPKVDVYSFGLVLWE 487 K+ DFG+A +ED+ T R W APE + K DV+SFG++L E Sbjct: 408 KIADFGLA------RLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTE 461 Query: 486 LVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIV 310 LV+ G +PY M + V + R P CP L +LM+ CW P++RP F I Sbjct: 462 LVTKGRVPYPGMVNREVLEQV-ERGYRMPCPQGCPESLHELMKLCWKKDPDERPTFEYIQ 520 Query: 309 QTLENLKTALD 277 LE+ TA + Sbjct: 521 SFLEDYFTATE 531
>ABL1_CAEEL (P03949) Tyrosine-protein kinase abl-1 (EC 2.7.10.2)| Length = 1224 Score = 70.1 bits (170), Expect = 6e-12 Identities = 43/138 (31%), Positives = 68/138 (49%), Gaps = 9/138 (6%) Frame = -1 Query: 642 KVVDFGVAFENVYCNTLEDDPGT--------YRWMAPEMCKRKPYGPKVDVYSFGLVLWE 487 K+ DFG+A +++D T +W APE + K DV++FG++LWE Sbjct: 447 KIADFGLA------RFMKEDTYTAHAGAKFPIKWTAPEGLAFNTFSSKSDVWAFGVLLWE 500 Query: 486 LVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIV 310 + + G PY + L Y ++ R P CP + +LM QCW+ P RP F +I Sbjct: 501 IATYGMAPYPGV-ELSNVYGLLENGFRMDGPQGCPPSVYRLMLQCWNWSPSDRPRFRDIH 559 Query: 309 QTLENLKTALDRDGTIEK 256 LENL ++ + ++K Sbjct: 560 FNLENLISSNSLNDEVQK 577
>RAF_MSV36 (P00532) Serine/threonine-protein kinase transforming protein raf| (EC 2.7.11.1) Length = 323 Score = 70.1 bits (170), Expect = 6e-12 Identities = 44/155 (28%), Positives = 80/155 (51%), Gaps = 10/155 (6%) Frame = -1 Query: 642 KVVDFGVAFENVYCN---TLEDDPGTYRWMAPEMCKRK---PYGPKVDVYSFGLVLWELV 481 K+ DFG+A + +E G+ WMAPE+ + + P+ + DVYS+G+VL+EL+ Sbjct: 158 KIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDDNPFSFQSDVYSYGIVLYELM 217 Query: 480 SGSIPYEEMTPLQAAYAVVNKNLR----PIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEI 313 +G +PY + +V + + +CP +++L+ C E+RP+F +I Sbjct: 218 AGELPYAHINNRDQIIFMVGRGYASPDLSRLYKNCPKAIKRLVADCVKKVKEERPLFPQI 277 Query: 312 VQTLENLKTALDRDGTIEKTPTPSCQEAAQEQNKN 208 + ++E L+ +L + P PS AA ++ N Sbjct: 278 LSSIELLQHSLPKIN--RSAPEPSLHRAAHTEDIN 310
>TIE1_BOVIN (Q06805) Tyrosine-protein kinase receptor Tie-1 precursor (EC| 2.7.10.1) Length = 1136 Score = 70.1 bits (170), Expect = 6e-12 Identities = 47/128 (36%), Positives = 67/128 (52%), Gaps = 3/128 (2%) Frame = -1 Query: 657 QKCCAKVVDFGVAF-ENVYCN-TLEDDPGTYRWMAPEMCKRKPYGPKVDVYSFGLVLWEL 484 + +K+ DFG++ E VY T+ P RWMA E Y K DV+SFG++LWE+ Sbjct: 987 ENLASKIADFGLSRGEEVYVKKTMGRLP--VRWMAIESLNYSVYTTKSDVWSFGVLLWEI 1044 Query: 483 VS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIVQ 307 VS G PY MT + Y + + R P +C + +LM QCW +P +RP F +I Sbjct: 1045 VSLGGTPYCGMTCAE-LYEKLPQAYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIAL 1103 Query: 306 TLENLKTA 283 L + A Sbjct: 1104 QLGRMLEA 1111
>MOS_MSVTS (P10421) Serine/threonine-protein kinase transforming protein mos| (EC 2.7.11.1) Length = 342 Score = 70.1 bits (170), Expect = 6e-12 Identities = 46/137 (33%), Positives = 70/137 (51%), Gaps = 9/137 (6%) Frame = -1 Query: 663 STQKCCAKVVDFGVA--FENVYCNTLEDD-PGTYRWMAPEMCKRKPYGPKVDVYSFGLVL 493 S Q C K+ DFG + +++ C GTY APE+ K + PK D+YSFG+ L Sbjct: 207 SEQDVC-KISDFGCSQKLQDLRCRQSPHHIGGTYTHQAPEILKGEIATPKADIYSFGITL 265 Query: 492 WELVSGSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPT------PLQQLMEQCWSAQPEKR 331 W++ + +PY P YAVV NLRP + + T LQ +++ CW A+ +R Sbjct: 266 WQMTTREVPYSG-EPQYVQYAVVAYNLRPSLTGAVFTASLTRKTLQNIIQNCWEARALQR 324 Query: 330 PVFTEIVQTLENLKTAL 280 P + + L+ + AL Sbjct: 325 PGAELLQRDLKAFRGAL 341
>MET_OTOGA (Q2QLH6) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1382 Score = 69.7 bits (169), Expect = 8e-12 Identities = 41/122 (33%), Positives = 68/122 (55%), Gaps = 8/122 (6%) Frame = -1 Query: 642 KVVDFGVA-------FENVYCNTLEDDPGTYRWMAPEMCKRKPYGPKVDVYSFGLVLWEL 484 KV DFG+A + +V+ T P +WMA E + + + K DV+SFG++LWEL Sbjct: 1220 KVADFGLARDMYDKEYYSVHNKTGAKLP--VKWMALESLQTQKFTTKSDVWSFGVLLWEL 1277 Query: 483 VS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIVQ 307 ++ G+ PY ++ ++ + R + P CP PL ++M +CW + E RP F+E+V Sbjct: 1278 MTRGAPPYPDVNTFDITVYLL-QGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVS 1336 Query: 306 TL 301 + Sbjct: 1337 RI 1338
>YES_XENLA (P10936) Tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes)| Length = 536 Score = 69.7 bits (169), Expect = 8e-12 Identities = 46/131 (35%), Positives = 64/131 (48%), Gaps = 9/131 (6%) Frame = -1 Query: 642 KVVDFGVAFENVYCNTLEDDPGTYR--------WMAPEMCKRKPYGPKVDVYSFGLVLWE 487 K+ DFG+A +ED+ T R W APE + K DV+SFG++L E Sbjct: 404 KIADFGLA------RLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTE 457 Query: 486 LVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIV 310 LV+ G +PY M + V + R P CP L +LM+ CW P++RP F I Sbjct: 458 LVAKGRVPYPGMVNREVLEQV-ERGYRMPCPQRCPESLHELMKLCWKKDPDERPTFEYIQ 516 Query: 309 QTLENLKTALD 277 LE+ TA + Sbjct: 517 SFLEDYFTATE 527
>FYN_HUMAN (P06241) Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2)| (p59-Fyn) (Protooncogene Syn) (SLK) Length = 536 Score = 69.7 bits (169), Expect = 8e-12 Identities = 46/131 (35%), Positives = 63/131 (48%), Gaps = 9/131 (6%) Frame = -1 Query: 642 KVVDFGVAFENVYCNTLEDDPGTYR--------WMAPEMCKRKPYGPKVDVYSFGLVLWE 487 K+ DFG+A +ED+ T R W APE + K DV+SFG++L E Sbjct: 404 KIADFGLA------RLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTE 457 Query: 486 LVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIV 310 LV+ G +PY M + V + R P CP L +LM CW PE+RP F + Sbjct: 458 LVTKGRVPYPGMNNREVLEQV-ERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQ 516 Query: 309 QTLENLKTALD 277 LE+ TA + Sbjct: 517 SFLEDYFTATE 527
>TESK1_RAT (Q63572) Dual specificity testis-specific protein kinase 1 (EC| 2.7.12.1) (Testicular protein kinase 1) Length = 628 Score = 69.7 bits (169), Expect = 8e-12 Identities = 46/137 (33%), Positives = 66/137 (48%), Gaps = 5/137 (3%) Frame = -1 Query: 645 AKVVDFGVAFE-NVYCNTLEDDP----GTYRWMAPEMCKRKPYGPKVDVYSFGLVLWELV 481 A V DFG+A + VY +P G+ WMAPE+ + + Y K DV++FG+VL EL+ Sbjct: 187 AVVGDFGLAEKIPVYREGARKEPLAVVGSPYWMAPEVLRGELYDEKADVFAFGIVLCELI 246 Query: 480 SGSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIVQTL 301 + + P + + R +V + CP P L C S +P R FTEI Q L Sbjct: 247 ARVPADPDYLPRTEDFGLDVPAFRTLVGNDCPLPFLLLAIHCCSMEPSARAPFTEITQHL 306 Query: 300 ENLKTALDRDGTIEKTP 250 E + L + K P Sbjct: 307 EQILEQLPEPTPLAKMP 323
>HCK_RAT (P50545) Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK)| (Hemopoietic cell kinase) Length = 502 Score = 69.7 bits (169), Expect = 8e-12 Identities = 43/125 (34%), Positives = 65/125 (52%), Gaps = 3/125 (2%) Frame = -1 Query: 642 KVVDFGVA--FENVYCNTLEDDPGTYRWMAPEMCKRKPYGPKVDVYSFGLVLWELVS-GS 472 K+ DFG+A E+ E +W APE + K DV+SFG++L E+V+ G Sbjct: 372 KIADFGLARIIEDNEYTAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGR 431 Query: 471 IPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIVQTLENL 292 IPY M+ + A+ + P P +CP L +M +CW +PE+RP F I L++ Sbjct: 432 IPYPGMSNPEVIRALEHGYRMPR-PDNCPEELYSIMIRCWKNRPEERPTFEYIQSVLDDF 490 Query: 291 KTALD 277 TA + Sbjct: 491 YTATE 495
>HCK_MOUSE (P08103) Tyrosine-protein kinase HCK (EC 2.7.10.2)| (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK) Length = 523 Score = 69.7 bits (169), Expect = 8e-12 Identities = 43/125 (34%), Positives = 65/125 (52%), Gaps = 3/125 (2%) Frame = -1 Query: 642 KVVDFGVA--FENVYCNTLEDDPGTYRWMAPEMCKRKPYGPKVDVYSFGLVLWELVS-GS 472 K+ DFG+A E+ E +W APE + K DV+SFG++L E+V+ G Sbjct: 393 KIADFGLARIIEDNEYTAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGR 452 Query: 471 IPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIVQTLENL 292 IPY M+ + A+ + P P +CP L +M +CW +PE+RP F I L++ Sbjct: 453 IPYPGMSNPEVIRALEHGYRMPR-PDNCPEELYNIMIRCWKNRPEERPTFEYIQSVLDDF 511 Query: 291 KTALD 277 TA + Sbjct: 512 YTATE 516
>INSRR_HUMAN (P14616) Insulin receptor-related protein precursor (EC 2.7.10.1)| (IRR) (IR-related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain] Length = 1297 Score = 69.7 bits (169), Expect = 8e-12 Identities = 42/125 (33%), Positives = 64/125 (51%), Gaps = 4/125 (3%) Frame = -1 Query: 660 TQKCCAKVVDFGVA---FENVYCNTLEDDPGTYRWMAPEMCKRKPYGPKVDVYSFGLVLW 490 +Q K+ DFG+ +E Y RWMAPE K + DV+SFG+VLW Sbjct: 1124 SQDFTVKIGDFGMTRDVYETDYYRKGGKGLLPVRWMAPESLKDGIFTTHSDVWSFGVVLW 1183 Query: 489 ELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEI 313 E+V+ PY+ ++ Q V++ + + CP LQ+LM +CW P RP FT I Sbjct: 1184 EIVTLAEQPYQGLSNEQVLKFVMDGGVLEEL-EGCPLQLQELMSRCWQPNPRLRPSFTHI 1242 Query: 312 VQTLE 298 + +++ Sbjct: 1243 LDSIQ 1247
>ABL1_HUMAN (P00519) Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2)| (p150) (c-ABL) (Abelson murine leukemia viral oncogene homolog 1) Length = 1130 Score = 69.3 bits (168), Expect = 1e-11 Identities = 43/133 (32%), Positives = 63/133 (47%), Gaps = 4/133 (3%) Frame = -1 Query: 642 KVVDFGVAFENVYCNTLEDDPGT---YRWMAPEMCKRKPYGPKVDVYSFGLVLWELVS-G 475 KV DFG++ + +T G +W APE + K DV++FG++LWE+ + G Sbjct: 378 KVADFGLS-RLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYG 436 Query: 474 SIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIVQTLEN 295 PY + L Y ++ K+ R P CP + +LM CW P RP F EI Q E Sbjct: 437 MSPYPGI-DLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFET 495 Query: 294 LKTALDRDGTIEK 256 + +EK Sbjct: 496 MFQESSISDEVEK 508
>MOS_MSVMT (P32593) Serine/threonine-protein kinase transforming protein mos| (EC 2.7.11.1) Length = 354 Score = 69.3 bits (168), Expect = 1e-11 Identities = 43/122 (35%), Positives = 62/122 (50%), Gaps = 10/122 (8%) Frame = -1 Query: 663 STQKCCAKVVDFGVAFENVYCNTLEDDP----GTYRWMAPEMCKRKPYGPKVDVYSFGLV 496 S Q C K+ DFG + + + P GTY APE+ K + PK D+YSFG+ Sbjct: 218 SEQDVC-KISDFGCSQKLQVLRGRQASPPHIGGTYTHQAPEILKGEIATPKADIYSFGIT 276 Query: 495 LWELVSGSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPT------PLQQLMEQCWSAQPEK 334 LW++ + +PY P YAVV NLRP + + T LQ +++ CW A+ + Sbjct: 277 LWQMTTREVPYSG-EPQYVQYAVVAYNLRPSLAGAVFTASLTGKALQNIIQSCWEARGLQ 335 Query: 333 RP 328 RP Sbjct: 336 RP 337
>MUSK_RAT (Q62838) Muscle, skeletal receptor tyrosine protein kinase precursor| (EC 2.7.10.1) (Muscle-specific kinase receptor) (MuSK) Length = 868 Score = 69.3 bits (168), Expect = 1e-11 Identities = 43/122 (35%), Positives = 60/122 (49%), Gaps = 5/122 (4%) Frame = -1 Query: 642 KVVDFGVAFENVYCNTLEDDPGT----YRWMAPEMCKRKPYGPKVDVYSFGLVLWELVS- 478 K+ DFG++ N+Y G RWM PE Y + DV+++G+VLWE+ S Sbjct: 739 KIADFGLS-RNIYSADYYKADGNDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSY 797 Query: 477 GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIVQTLE 298 G PY M + Y V + N+ P +CP L LM CWS P RP F I + L+ Sbjct: 798 GLQPYYGMAHEEVIYYVRDGNILAC-PENCPLELYNLMRLCWSKLPADRPSFCSIHRILQ 856 Query: 297 NL 292 + Sbjct: 857 RM 858
>MUSK_MOUSE (Q61006) Muscle, skeletal receptor tyrosine protein kinase precursor| (EC 2.7.10.1) (Muscle-specific kinase receptor) (MuSK) Length = 868 Score = 69.3 bits (168), Expect = 1e-11 Identities = 43/122 (35%), Positives = 60/122 (49%), Gaps = 5/122 (4%) Frame = -1 Query: 642 KVVDFGVAFENVYCNTLEDDPGT----YRWMAPEMCKRKPYGPKVDVYSFGLVLWELVS- 478 K+ DFG++ N+Y G RWM PE Y + DV+++G+VLWE+ S Sbjct: 739 KIADFGLS-RNIYSADYYKADGNDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSY 797 Query: 477 GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIVQTLE 298 G PY M + Y V + N+ P +CP L LM CWS P RP F I + L+ Sbjct: 798 GLQPYYGMAHEEVIYYVRDGNILAC-PENCPLELYNLMRLCWSKLPADRPSFCSIHRILQ 856 Query: 297 NL 292 + Sbjct: 857 RM 858
>MET_MOUSE (P16056) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1379 Score = 69.3 bits (168), Expect = 1e-11 Identities = 41/130 (31%), Positives = 71/130 (54%), Gaps = 8/130 (6%) Frame = -1 Query: 657 QKCCAKVVDFGVA-------FENVYCNTLEDDPGTYRWMAPEMCKRKPYGPKVDVYSFGL 499 +K KV DFG+A + +V+ T P +WMA E + + + K DV+SFG+ Sbjct: 1212 EKFTVKVADFGLARDMYDKEYYSVHNKTGAKLP--VKWMALESLQTQKFTTKSDVWSFGV 1269 Query: 498 VLWELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVF 322 +LWEL++ G+ PY ++ ++ + R + P CP L ++M +CW + E RP F Sbjct: 1270 LLWELMTRGAPPYPDVNTFDITIYLL-QGRRLLQPEYCPDALYEVMLKCWHPKAEMRPSF 1328 Query: 321 TEIVQTLENL 292 +E+V + ++ Sbjct: 1329 SELVSRISSI 1338
>ABL_MLVAB (P00521) Tyrosine-protein kinase transforming protein Abl (EC| 2.7.10.2) (V-abl) Length = 746 Score = 69.3 bits (168), Expect = 1e-11 Identities = 43/133 (32%), Positives = 63/133 (47%), Gaps = 4/133 (3%) Frame = -1 Query: 642 KVVDFGVAFENVYCNTLEDDPGT---YRWMAPEMCKRKPYGPKVDVYSFGLVLWELVS-G 475 KV DFG++ + +T G +W APE + K DV++FG++LWE+ + G Sbjct: 264 KVADFGLS-RLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYG 322 Query: 474 SIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIVQTLEN 295 PY + L Y ++ K+ R P CP + +LM CW P RP F EI Q E Sbjct: 323 MSPYPGI-DLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFET 381 Query: 294 LKTALDRDGTIEK 256 + +EK Sbjct: 382 MFQESSISDEVEK 394
>SRC_RAT (Q9WUD9) Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2)| (p60-Src) (c-Src) (pp60c-src) Length = 535 Score = 69.3 bits (168), Expect = 1e-11 Identities = 47/132 (35%), Positives = 64/132 (48%), Gaps = 9/132 (6%) Frame = -1 Query: 642 KVVDFGVAFENVYCNTLEDDPGTYR--------WMAPEMCKRKPYGPKVDVYSFGLVLWE 487 KV DFG+A +ED+ T R W APE + K DV+SFG++L E Sbjct: 403 KVADFGLA------RLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTE 456 Query: 486 LVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIV 310 L + G +PY M + V + R P CP L LM QCW +PE+RP F + Sbjct: 457 LTTKGRVPYPGMVNREVLDQV-ERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQ 515 Query: 309 QTLENLKTALDR 274 LE+ T+ +R Sbjct: 516 AFLEDYFTSTER 527
>ABL1_MOUSE (P00520) Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2)| (p150) (c-ABL) (Abelson murine leukemia viral oncogene homolog 1) Length = 1123 Score = 69.3 bits (168), Expect = 1e-11 Identities = 43/133 (32%), Positives = 63/133 (47%), Gaps = 4/133 (3%) Frame = -1 Query: 642 KVVDFGVAFENVYCNTLEDDPGT---YRWMAPEMCKRKPYGPKVDVYSFGLVLWELVS-G 475 KV DFG++ + +T G +W APE + K DV++FG++LWE+ + G Sbjct: 378 KVADFGLS-RLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYG 436 Query: 474 SIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIVQTLEN 295 PY + L Y ++ K+ R P CP + +LM CW P RP F EI Q E Sbjct: 437 MSPYPGI-DLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFET 495 Query: 294 LKTALDRDGTIEK 256 + +EK Sbjct: 496 MFQESSISDEVEK 508
>HCK_MACFA (Q95M30) Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK)| (Hemopoietic cell kinase) Length = 503 Score = 68.9 bits (167), Expect = 1e-11 Identities = 43/125 (34%), Positives = 64/125 (51%), Gaps = 3/125 (2%) Frame = -1 Query: 642 KVVDFGVA--FENVYCNTLEDDPGTYRWMAPEMCKRKPYGPKVDVYSFGLVLWELVS-GS 472 K+ DFG+A E+ E +W APE K DV+SFG++L E+V+ G Sbjct: 373 KIADFGLARIIEDNEYTAREGAKFPIKWTAPEAINFGSSTIKSDVWSFGILLMEIVTYGR 432 Query: 471 IPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIVQTLENL 292 IPY M+ + A+ + R P +CP L +M +CW +PE+RP F I L++ Sbjct: 433 IPYPGMSNPEVIRAL-ERGYRMPRPENCPEELYNIMMRCWKNRPEERPTFEYIQSVLDDF 491 Query: 291 KTALD 277 TA + Sbjct: 492 YTATE 496
>FYN_XENLA (P13406) Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2)| (p59-Fyn) Length = 536 Score = 68.9 bits (167), Expect = 1e-11 Identities = 46/131 (35%), Positives = 63/131 (48%), Gaps = 9/131 (6%) Frame = -1 Query: 642 KVVDFGVAFENVYCNTLEDDPGTYR--------WMAPEMCKRKPYGPKVDVYSFGLVLWE 487 K+ DFG+A +ED+ T R W APE + K DV+SFG++L E Sbjct: 404 KIADFGLA------RLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTE 457 Query: 486 LVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIV 310 LV+ G +PY M + V + R P CP L +LM CW PE+RP F + Sbjct: 458 LVTKGRVPYPGMNNREVLEQV-ERGYRMPCPQDCPISLHELMLNCWKKDPEERPTFEYLQ 516 Query: 309 QTLENLKTALD 277 LE+ TA + Sbjct: 517 GFLEDYFTATE 527
>FYN_MOUSE (P39688) Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2)| (p59-Fyn) Length = 533 Score = 68.9 bits (167), Expect = 1e-11 Identities = 46/131 (35%), Positives = 63/131 (48%), Gaps = 9/131 (6%) Frame = -1 Query: 642 KVVDFGVAFENVYCNTLEDDPGTYR--------WMAPEMCKRKPYGPKVDVYSFGLVLWE 487 K+ DFG+A +ED+ T R W APE + K DV+SFG++L E Sbjct: 401 KIADFGLA------RLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTE 454 Query: 486 LVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIV 310 LV+ G +PY M + V + R P CP L +LM CW PE+RP F + Sbjct: 455 LVTKGRVPYPGMNNREVLEQV-ERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQ 513 Query: 309 QTLENLKTALD 277 LE+ TA + Sbjct: 514 GFLEDYFTATE 524
>FYN_CHICK (Q05876) Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2)| (p59-Fyn) Length = 533 Score = 68.9 bits (167), Expect = 1e-11 Identities = 46/131 (35%), Positives = 63/131 (48%), Gaps = 9/131 (6%) Frame = -1 Query: 642 KVVDFGVAFENVYCNTLEDDPGTYR--------WMAPEMCKRKPYGPKVDVYSFGLVLWE 487 K+ DFG+A +ED+ T R W APE + K DV+SFG++L E Sbjct: 401 KIADFGLA------RLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTE 454 Query: 486 LVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIV 310 LV+ G +PY M + V + R P CP L +LM CW PE+RP F + Sbjct: 455 LVTKGRVPYPGMNNREVLEQV-ERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQ 513 Query: 309 QTLENLKTALD 277 LE+ TA + Sbjct: 514 GFLEDYFTATE 524
>RET_HUMAN (P07949) Proto-oncogene tyrosine-protein kinase receptor ret| precursor (EC 2.7.10.1) (C-ret) Length = 1114 Score = 68.9 bits (167), Expect = 1e-11 Identities = 44/126 (34%), Positives = 68/126 (53%), Gaps = 9/126 (7%) Frame = -1 Query: 642 KVVDFGVAFENVYCNTLEDDPGTYR--------WMAPEMCKRKPYGPKVDVYSFGLVLWE 487 K+ DFG++ +VY E+D R WMA E Y + DV+SFG++LWE Sbjct: 889 KISDFGLS-RDVY----EEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWE 943 Query: 486 LVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIV 310 +V+ G PY + P + + ++ R P +C + +LM QCW +P+KRPVF +I Sbjct: 944 IVTLGGNPYPGIPP-ERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADIS 1002 Query: 309 QTLENL 292 + LE + Sbjct: 1003 KDLEKM 1008
>EPHB3_XENLA (Q91735) Ephrin type-B receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor TCK) Length = 974 Score = 68.9 bits (167), Expect = 1e-11 Identities = 44/128 (34%), Positives = 65/128 (50%), Gaps = 11/128 (8%) Frame = -1 Query: 642 KVVDFGVAFENVYCNTLEDDPGTY----------RWMAPEMCKRKPYGPKVDVYSFGLVL 493 KV DFG++ + DP TY RW APE + + DV+S+G+V+ Sbjct: 749 KVSDFGLSR---FLENSRSDP-TYTSALGGKIPIRWTAPEAISYRKFTSASDVWSYGIVM 804 Query: 492 WELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTE 316 WE++S G PY +M+ Q + ++ R P CP+ L QLM CW RP F++ Sbjct: 805 WEVMSYGERPYWDMSN-QDVINAIEQDYRLPPPMDCPSALHQLMLDCWLRDRNLRPKFSQ 863 Query: 315 IVQTLENL 292 IV +L+ L Sbjct: 864 IVSSLDKL 871
>STK24_MOUSE (Q99KH8) Serine/threonine-protein kinase 24 (EC 2.7.11.1)| Length = 431 Score = 68.9 bits (167), Expect = 1e-11 Identities = 38/116 (32%), Positives = 63/116 (54%), Gaps = 4/116 (3%) Frame = -1 Query: 642 KVVDFGVAFE----NVYCNTLEDDPGTYRWMAPEMCKRKPYGPKVDVYSFGLVLWELVSG 475 K+ DFGVA + + NT GT WMAPE+ K+ Y K D++S G+ EL G Sbjct: 159 KLADFGVAGQLTDTQIKRNTFV---GTPFWMAPEVIKQSAYDSKADIWSLGITAIELAKG 215 Query: 474 SIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIVQ 307 P+ E+ P++ + ++ KN P + + PL++ +E C + +P RP E+++ Sbjct: 216 EPPHSELHPMKVLF-LIPKNNPPTLEGNYSKPLKEFVEACLNKEPSFRPTAKELLK 270
>VGFR3_RAT (Q91ZT1) Vascular endothelial growth factor receptor 3 precursor (EC| 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4) Length = 1363 Score = 68.6 bits (166), Expect = 2e-11 Identities = 41/133 (30%), Positives = 68/133 (51%), Gaps = 5/133 (3%) Frame = -1 Query: 675 RTFCSTQKCCAKVVDFGVAFENVYCNTLEDDPGTYR----WMAPEMCKRKPYGPKVDVYS 508 R ++ K+ DFG+A ++Y + G+ R WMAPE K Y + DV+S Sbjct: 1041 RNILLSESDIVKICDFGLA-RDIYKDPDYVRKGSARLPLKWMAPESIFDKVYTTQSDVWS 1099 Query: 507 FGLVLWELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKR 331 FG++LWE+ S G+ PY + + + R P ++ +M+ CWS P+ R Sbjct: 1100 FGVLLWEIFSLGASPYPGVQINEEFCQRLKDGTRMRAPELATPAIRHIMQSCWSGDPKAR 1159 Query: 330 PVFTEIVQTLENL 292 P F+++V+ L +L Sbjct: 1160 PAFSDLVEILGDL 1172
>VGFR3_MOUSE (P35917) Vascular endothelial growth factor receptor 3 precursor (EC| 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4) Length = 1363 Score = 68.6 bits (166), Expect = 2e-11 Identities = 41/133 (30%), Positives = 68/133 (51%), Gaps = 5/133 (3%) Frame = -1 Query: 675 RTFCSTQKCCAKVVDFGVAFENVYCNTLEDDPGTYR----WMAPEMCKRKPYGPKVDVYS 508 R ++ K+ DFG+A ++Y + G+ R WMAPE K Y + DV+S Sbjct: 1041 RNILLSESDIVKICDFGLA-RDIYKDPDYVRKGSARLPLKWMAPESIFDKVYTTQSDVWS 1099 Query: 507 FGLVLWELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKR 331 FG++LWE+ S G+ PY + + + R P ++ +M+ CWS P+ R Sbjct: 1100 FGVLLWEIFSLGASPYPGVQINEEFCQRLKDGTRMRAPELATPAIRHIMQSCWSGDPKAR 1159 Query: 330 PVFTEIVQTLENL 292 P F+++V+ L +L Sbjct: 1160 PAFSDLVEILGDL 1172
>PTK7_CHICK (Q91048) Tyrosine-protein kinase-like 7 precursor (Kinase-like| protein) Length = 1051 Score = 68.6 bits (166), Expect = 2e-11 Identities = 30/91 (32%), Positives = 51/91 (56%), Gaps = 1/91 (1%) Frame = -1 Query: 570 RWMAPEMCKRKPYGPKVDVYSFGLVLWELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPS 394 RWM PE + K DV+SFG+++WE+ + G +PY + + + + + P Sbjct: 952 RWMPPEAVLEDEFSTKSDVWSFGVLMWEVFTQGEMPYAPLADDEVLAGLKSGKTKLPQPE 1011 Query: 393 SCPTPLQQLMEQCWSAQPEKRPVFTEIVQTL 301 CP+ L +LM++CW+ P+ RP F+E+ L Sbjct: 1012 GCPSRLTKLMQRCWAPSPKDRPSFSELAAAL 1042
>VGFR2_BRARE (Q8AXB3) Vascular endothelial growth factor receptor 2 precursor (EC| 2.7.10.1) (VEGFR-2) (Receptor tyrosine kinase flk-1) Length = 1302 Score = 68.6 bits (166), Expect = 2e-11 Identities = 44/136 (32%), Positives = 68/136 (50%), Gaps = 5/136 (3%) Frame = -1 Query: 675 RTFCSTQKCCAKVVDFGVAFENVYCNTLEDDPGTYR----WMAPEMCKRKPYGPKVDVYS 508 R ++ K+ DFG+A +VY + G R WMAPE K Y + DV+S Sbjct: 1007 RNILLSENNVVKICDFGLA-RDVYKDPDYVRKGDARLPLKWMAPEAIFDKIYTTQSDVWS 1065 Query: 507 FGLVLWELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKR 331 FG+++WE+ S G+ PY + + + + R P + + Q M CW +P +R Sbjct: 1066 FGVLMWEIFSLGASPYPGLHIDEEFCCRLKEGTRMKAPEYSSSEIYQTMLDCWHGEPSQR 1125 Query: 330 PVFTEIVQTLENLKTA 283 P FTE+V+ L +L A Sbjct: 1126 PTFTELVERLGDLLQA 1141
>EPHB1_CHICK (Q07494) Ephrin type-B receptor 1 (EC 2.7.10.1) (Tyrosine-protein| kinase receptor EPH-2) (Tyrosine kinase CEK6 receptor) (Fragment) Length = 984 Score = 68.6 bits (166), Expect = 2e-11 Identities = 45/130 (34%), Positives = 63/130 (48%), Gaps = 13/130 (10%) Frame = -1 Query: 642 KVVDFGVAFENVYCNTLEDDPG--TY----------RWMAPEMCKRKPYGPKVDVYSFGL 499 KV DFG++ L+DD TY RW APE + + DV+S+G+ Sbjct: 759 KVSDFGLS------RYLQDDTSDPTYTSSLGGKIPVRWTAPEAIAYRKFTSASDVWSYGI 812 Query: 498 VLWELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVF 322 V+WE++S G PY +M+ Q + ++ R P CP L QLM CW RP Sbjct: 813 VMWEVMSFGERPYWDMSN-QDVINAIEQDYRLPPPMDCPAALHQLMLDCWQKDRNTRPRL 871 Query: 321 TEIVQTLENL 292 EIV TL+ + Sbjct: 872 AEIVNTLDKM 881
>SRMS_MOUSE (Q62270) Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70)| Length = 496 Score = 68.6 bits (166), Expect = 2e-11 Identities = 43/130 (33%), Positives = 66/130 (50%), Gaps = 9/130 (6%) Frame = -1 Query: 642 KVVDFGVAFENVYCNTLEDD---PGT-----YRWMAPEMCKRKPYGPKVDVYSFGLVLWE 487 KV DFG+A L+DD P + +W APE + + K DV+SFG++L+E Sbjct: 369 KVADFGLA------RLLKDDVYSPSSGSKIPVKWTAPEAANYRVFSQKSDVWSFGILLYE 422 Query: 486 LVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIV 310 + + G PYE MT + + ++ R P+ CP + LM +CW PE+RP F + Sbjct: 423 VFTYGQCPYEGMTNHETLQQI-SRGYRLPRPAVCPAEVYVLMVECWKGSPEERPTFAILR 481 Query: 309 QTLENLKTAL 280 + L + L Sbjct: 482 EKLNAINRRL 491
>RET_MOUSE (P35546) Proto-oncogene tyrosine-protein kinase receptor ret| precursor (EC 2.7.10.1) (C-ret) Length = 1115 Score = 68.6 bits (166), Expect = 2e-11 Identities = 40/111 (36%), Positives = 60/111 (54%), Gaps = 1/111 (0%) Frame = -1 Query: 570 RWMAPEMCKRKPYGPKVDVYSFGLVLWELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPS 394 +WMA E Y + DV+SFG++LWE+V+ G PY + P + + ++ R P Sbjct: 917 KWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPP-ERLFNLLKTGHRMERPD 975 Query: 393 SCPTPLQQLMEQCWSAQPEKRPVFTEIVQTLENLKTALDRDGTIEKTPTPS 241 +C + +LM QCW +P+KRPVF +I + LE + RD TPS Sbjct: 976 NCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVK-SRDYLDLAASTPS 1025
>STK24_HUMAN (Q9Y6E0) Serine/threonine-protein kinase 24 (EC 2.7.11.1)| (STE20-like kinase MST3) (MST-3) (Mammalian STE20-like protein kinase 3) Length = 443 Score = 68.6 bits (166), Expect = 2e-11 Identities = 38/116 (32%), Positives = 63/116 (54%), Gaps = 4/116 (3%) Frame = -1 Query: 642 KVVDFGVAFE----NVYCNTLEDDPGTYRWMAPEMCKRKPYGPKVDVYSFGLVLWELVSG 475 K+ DFGVA + + NT GT WMAPE+ K+ Y K D++S G+ EL G Sbjct: 171 KLADFGVAGQLTDTQIKRNTFV---GTPFWMAPEVIKQSAYDSKADIWSLGITAIELARG 227 Query: 474 SIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIVQ 307 P+ E+ P++ + ++ KN P + + PL++ +E C + +P RP E+++ Sbjct: 228 EPPHSELHPMKVLF-LIPKNNPPTLEGNYSKPLKEFVEACLNKEPSFRPTAKELLK 282
>MOS_MSVMO (P00538) Serine/threonine-protein kinase transforming protein mos| (EC 2.7.11.1) Length = 374 Score = 68.6 bits (166), Expect = 2e-11 Identities = 43/122 (35%), Positives = 62/122 (50%), Gaps = 10/122 (8%) Frame = -1 Query: 663 STQKCCAKVVDFGVAFENVYCNTLEDDP----GTYRWMAPEMCKRKPYGPKVDVYSFGLV 496 S Q C K+ DFG + + + P GTY APE+ K + PK D+YSFG+ Sbjct: 238 SEQDVC-KISDFGCSQKLQDLRGRQASPPHIGGTYTHQAPEILKGEIATPKADIYSFGIT 296 Query: 495 LWELVSGSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPT------PLQQLMEQCWSAQPEK 334 LW++ + +PY P YAVV NLRP + + T LQ +++ CW A+ + Sbjct: 297 LWQMTTREVPYSG-EPQYVQYAVVAYNLRPSLAGAVFTASLTGKALQNIIQSCWEARGLQ 355 Query: 333 RP 328 RP Sbjct: 356 RP 357
>INSR_MOUSE (P15208) Insulin receptor precursor (EC 2.7.10.1) (IR) [Contains:| Insulin receptor alpha subunit; Insulin receptor beta subunit] Length = 1372 Score = 68.2 bits (165), Expect = 2e-11 Identities = 43/121 (35%), Positives = 61/121 (50%), Gaps = 5/121 (4%) Frame = -1 Query: 642 KVVDFGVA---FENVYCNTLEDDPGTYRWMAPEMCKRKPYGPKVDVYSFGLVLWELVS-G 475 K+ DFG+ +E Y RWM+PE K + D++SFG+VLWE+ S Sbjct: 1164 KIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTASSDMWSFGVVLWEITSLA 1223 Query: 474 SIPYEEMTPLQAAYAVVNKN-LRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIVQTLE 298 PY+ ++ Q V++ L P P +CP L LM CW P+ RP F EIV L+ Sbjct: 1224 EQPYQGLSNEQVLKFVMDGGYLDP--PDNCPERLTDLMRMCWQFNPKMRPTFLEIVNLLK 1281 Query: 297 N 295 + Sbjct: 1282 D 1282
>IGF1R_MOUSE (Q60751) Insulin-like growth factor 1 receptor precursor (EC| 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain] Length = 1373 Score = 68.2 bits (165), Expect = 2e-11 Identities = 49/151 (32%), Positives = 70/151 (46%), Gaps = 7/151 (4%) Frame = -1 Query: 642 KVVDFGVA---FENVYCNTLEDDPGTYRWMAPEMCKRKPYGPKVDVYSFGLVLWELVS-G 475 K+ DFG+ +E Y RWM+PE K + DV+SFG+VLWE+ + Sbjct: 1152 KIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTHSDVWSFGVVLWEIATLA 1211 Query: 474 SIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIVQTLEN 295 PY+ ++ Q V+ L P +CP L +LM CW P+ RP F EI+ Sbjct: 1212 EQPYQGLSNEQVLRFVMEGGLLD-KPDNCPDMLFELMRMCWQYNPKMRPSFLEII----- 1265 Query: 294 LKTALDRDGTIEKTPTPSCQEAA---QEQNK 211 G+I+ PS QE + E+NK Sbjct: 1266 --------GSIKDEMEPSFQEVSFYYSEENK 1288
>FGR_MOUSE (P14234) Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2)| (P55-FGR) (C-FGR) Length = 517 Score = 68.2 bits (165), Expect = 2e-11 Identities = 42/125 (33%), Positives = 63/125 (50%), Gaps = 3/125 (2%) Frame = -1 Query: 642 KVVDFGVA--FENVYCNTLEDDPGTYRWMAPEMCKRKPYGPKVDVYSFGLVLWELVS-GS 472 K+ DFG+A E+ N + +W APE + K DV+SFG++L EL++ G Sbjct: 385 KIADFGLARLIEDNEYNPQQGTKFPIKWTAPEAALFGRFTVKSDVWSFGILLTELITKGR 444 Query: 471 IPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIVQTLENL 292 +PY M + V + P P CP L ++MEQ W PE+RP F + LE+ Sbjct: 445 VPYPGMNNREVLEQVEHGYHMPC-PPGCPASLYEVMEQAWRLDPEERPTFEYLQSFLEDY 503 Query: 291 KTALD 277 T+ + Sbjct: 504 FTSTE 508
>INSR_RAT (P15127) Insulin receptor precursor (EC 2.7.10.1) (IR) [Contains:| Insulin receptor alpha subunit; Insulin receptor beta subunit] Length = 1383 Score = 68.2 bits (165), Expect = 2e-11 Identities = 43/121 (35%), Positives = 61/121 (50%), Gaps = 5/121 (4%) Frame = -1 Query: 642 KVVDFGVA---FENVYCNTLEDDPGTYRWMAPEMCKRKPYGPKVDVYSFGLVLWELVS-G 475 K+ DFG+ +E Y RWM+PE K + D++SFG+VLWE+ S Sbjct: 1175 KIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTASSDMWSFGVVLWEITSLA 1234 Query: 474 SIPYEEMTPLQAAYAVVNKN-LRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIVQTLE 298 PY+ ++ Q V++ L P P +CP L LM CW P+ RP F EIV L+ Sbjct: 1235 EQPYQGLSNEQVLKFVMDGGYLDP--PDNCPERLTDLMRMCWQFNPKMRPTFLEIVNLLK 1292 Query: 297 N 295 + Sbjct: 1293 D 1293
>VGFR2_HUMAN (P35968) Vascular endothelial growth factor receptor 2 precursor (EC| 2.7.10.1) (VEGFR-2) (Kinase insert domain receptor) (Protein-tyrosine kinase receptor Flk-1) (CD309 antigen) Length = 1356 Score = 68.2 bits (165), Expect = 2e-11 Identities = 44/136 (32%), Positives = 68/136 (50%), Gaps = 5/136 (3%) Frame = -1 Query: 675 RTFCSTQKCCAKVVDFGVAFENVYCNTLEDDPGTYR----WMAPEMCKRKPYGPKVDVYS 508 R ++K K+ DFG+A ++Y + G R WMAPE + Y + DV+S Sbjct: 1032 RNILLSEKNVVKICDFGLA-RDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWS 1090 Query: 507 FGLVLWELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKR 331 FG++LWE+ S G+ PY + + + + R P + Q M CW +P +R Sbjct: 1091 FGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQR 1150 Query: 330 PVFTEIVQTLENLKTA 283 P F+E+V+ L NL A Sbjct: 1151 PTFSELVEHLGNLLQA 1166
>SRC2_XENLA (P13116) Tyrosine-protein kinase Src-2 (EC 2.7.10.2) (p60-Src-2)| Length = 531 Score = 68.2 bits (165), Expect = 2e-11 Identities = 47/131 (35%), Positives = 62/131 (47%), Gaps = 9/131 (6%) Frame = -1 Query: 642 KVVDFGVAFENVYCNTLEDDPGTYR--------WMAPEMCKRKPYGPKVDVYSFGLVLWE 487 KV DFG+A +ED+ T R W APE + K DV+SFG++L E Sbjct: 399 KVADFGLA------RLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTE 452 Query: 486 LVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIV 310 L + G +PY M + V + R P CP L LM QCW PE+RP F + Sbjct: 453 LTTKGRVPYPGMVNREVLDQV-ERGYRMPCPPDCPESLHDLMFQCWRKDPEERPTFEYLQ 511 Query: 309 QTLENLKTALD 277 LE+ TA + Sbjct: 512 AFLEDYFTATE 522
>SRC1_XENLA (P13115) Tyrosine-protein kinase Src-1 (EC 2.7.10.2) (p60-Src-1)| Length = 531 Score = 68.2 bits (165), Expect = 2e-11 Identities = 47/131 (35%), Positives = 62/131 (47%), Gaps = 9/131 (6%) Frame = -1 Query: 642 KVVDFGVAFENVYCNTLEDDPGTYR--------WMAPEMCKRKPYGPKVDVYSFGLVLWE 487 KV DFG+A +ED+ T R W APE + K DV+SFG++L E Sbjct: 399 KVADFGLA------RLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTE 452 Query: 486 LVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIV 310 L + G +PY M + V + R P CP L LM QCW PE+RP F + Sbjct: 453 LTTKGRVPYPGMVNREVLDQV-ERGYRMPCPPDCPESLHDLMFQCWRKDPEERPTFEYLQ 511 Query: 309 QTLENLKTALD 277 LE+ TA + Sbjct: 512 AFLEDYFTATE 522
>ABL_FSVHY (P10447) Tyrosine-protein kinase transforming protein Abl (EC| 2.7.10.2) (V-abl) Length = 439 Score = 68.2 bits (165), Expect = 2e-11 Identities = 40/114 (35%), Positives = 58/114 (50%), Gaps = 4/114 (3%) Frame = -1 Query: 642 KVVDFGVAFENVYCNTLEDDPGT---YRWMAPEMCKRKPYGPKVDVYSFGLVLWELVS-G 475 KV DFG++ + +T GT +W APE + K DV++FG++LWE+ + G Sbjct: 327 KVADFGLS-RLMTGDTYTAHAGTKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYG 385 Query: 474 SIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEI 313 PY + L Y ++ K+ R P CP + +LM CW P RP F EI Sbjct: 386 MSPYPGI-DLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPAFAEI 438
>IGF1R_RAT (P24062) Insulin-like growth factor 1 receptor precursor (EC| 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain] Length = 1370 Score = 68.2 bits (165), Expect = 2e-11 Identities = 49/151 (32%), Positives = 70/151 (46%), Gaps = 7/151 (4%) Frame = -1 Query: 642 KVVDFGVA---FENVYCNTLEDDPGTYRWMAPEMCKRKPYGPKVDVYSFGLVLWELVS-G 475 K+ DFG+ +E Y RWM+PE K + DV+SFG+VLWE+ + Sbjct: 1151 KIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTHSDVWSFGVVLWEIATLA 1210 Query: 474 SIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIVQTLEN 295 PY+ ++ Q V+ L P +CP L +LM CW P+ RP F EI+ Sbjct: 1211 EQPYQGLSNEQVLRFVMEGGLLD-KPDNCPDMLFELMRMCWQYNPKMRPSFLEII----- 1264 Query: 294 LKTALDRDGTIEKTPTPSCQEAA---QEQNK 211 G+I+ PS QE + E+NK Sbjct: 1265 --------GSIKDEMEPSFQEVSFYYSEENK 1287
>RON_MOUSE (Q62190) Macrophage-stimulating protein receptor precursor (EC| 2.7.10.1) (MSP receptor) (p185-Ron) (Stem cell-derived tyrosine kinase) (CDw136 antigen) [Contains: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating prote Length = 1378 Score = 68.2 bits (165), Expect = 2e-11 Identities = 42/136 (30%), Positives = 68/136 (50%), Gaps = 6/136 (4%) Frame = -1 Query: 642 KVVDFGVA---FENVYCNTLEDDPGTY--RWMAPEMCKRKPYGPKVDVYSFGLVLWELVS 478 KV DFG+A + Y + + +WMA E + + K DV+SFG++LWEL++ Sbjct: 1200 KVADFGLARGVLDKEYYSVRQHRHARLPVKWMALESLQTYRFTTKSDVWSFGVLLWELLT 1259 Query: 477 -GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIVQTL 301 G+ PY + P ++ + P P CP L +M +CW A P RP F +V + Sbjct: 1260 RGAPPYPHIDPFDLSHFLAQGRRLP-QPEYCPDSLYHVMLRCWEADPAARPTFRALVLEV 1318 Query: 300 ENLKTALDRDGTIEKT 253 + + +L D ++ T Sbjct: 1319 KQVVASLLGDHYVQLT 1334
>LRRK1_HUMAN (Q38SD2) Leucine-rich repeat serine/threonine-protein kinase 1 (EC| 2.7.11.1) Length = 2038 Score = 68.2 bits (165), Expect = 2e-11 Identities = 42/119 (35%), Positives = 70/119 (58%), Gaps = 3/119 (2%) Frame = -1 Query: 642 KVVDFGVAFENVYCNTLEDDPGTYRWMAPEMCKRKPYGPKVDVYSFGLVLWELVSGSIPY 463 K+ D+G++ ++ + L + GT + APE+ R Y KVD++S+G+VL+EL+SG P Sbjct: 1429 KLSDYGISRQSFHEGALGVE-GTPGYQAPEIRPRIVYDEKVDMFSYGMVLYELLSGQRPA 1487 Query: 462 EEMTPLQAAYAVVNKNLRPIV--PSSCP-TPLQQLMEQCWSAQPEKRPVFTEIVQTLEN 295 LQ A ++K +RP++ P LQ LM +CW +PEKRP+ +V +++ Sbjct: 1488 LGHHQLQIA-KKLSKGIRPVLGQPEEVQFRRLQALMMECWDTKPEKRPLALSVVSQMKD 1545
>TXK_HUMAN (P42681) Tyrosine-protein kinase TXK (EC 2.7.10.2)| Length = 527 Score = 68.2 bits (165), Expect = 2e-11 Identities = 36/124 (29%), Positives = 65/124 (52%), Gaps = 4/124 (3%) Frame = -1 Query: 651 CCAKVVDFGVA---FENVYCNTLEDDPGTYRWMAPEMCKRKPYGPKVDVYSFGLVLWELV 481 C K+ DFG+ ++ Y ++ +W PE+ Y K DV+SFG+++WE+ Sbjct: 402 CIVKISDFGMTRYVLDDEYVSSF-GAKFPIKWSPPEVFLFNKYSSKSDVWSFGVLMWEVF 460 Query: 480 S-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIVQT 304 + G +P+E + LQ A+ ++ R P P + ++M CW +PE RP F E+++ Sbjct: 461 TEGKMPFENKSNLQVVEAI-SEGFRLYRPHLAPMSIYEVMYSCWHEKPEGRPTFAELLRA 519 Query: 303 LENL 292 + + Sbjct: 520 VTEI 523
>ILK_MOUSE (O55222) Integrin-linked protein kinase (EC 2.7.11.1)| Length = 452 Score = 68.2 bits (165), Expect = 2e-11 Identities = 33/96 (34%), Positives = 55/96 (57%), Gaps = 3/96 (3%) Frame = -1 Query: 567 WMAPEMCKRKPYGPK---VDVYSFGLVLWELVSGSIPYEEMTPLQAAYAVVNKNLRPIVP 397 W+APE ++KP D++SF ++LWELV+ +P+ +++ ++ V + LRP VP Sbjct: 355 WVAPEALQKKPEDTNRRSADMWSFAVLLWELVTREVPFADLSNMEIGMKVALEGLRPTVP 414 Query: 396 SSCPTPLQQLMEQCWSAQPEKRPVFTEIVQTLENLK 289 + +LM+ C + P KRP F IV LE ++ Sbjct: 415 PGISPHVCKLMKICMNEDPAKRPKFDMIVPILEKMQ 450
>TIE2_BOVIN (Q06807) Angiopoietin-1 receptor precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor TIE-2) (CD202b antigen) Length = 1125 Score = 67.8 bits (164), Expect = 3e-11 Identities = 44/121 (36%), Positives = 65/121 (53%), Gaps = 3/121 (2%) Frame = -1 Query: 645 AKVVDFGVAF-ENVYCN-TLEDDPGTYRWMAPEMCKRKPYGPKVDVYSFGLVLWELVS-G 475 AK+ DFG++ + VY T+ P RWMA E Y DV+S+G++LWE+VS G Sbjct: 979 AKIADFGLSRGQEVYVKKTMGRLP--VRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLG 1036 Query: 474 SIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIVQTLEN 295 PY MT + Y + + R P +C + LM QCW +P +RP F +I+ +L Sbjct: 1037 GTPYCGMTCAE-LYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLNR 1095 Query: 294 L 292 + Sbjct: 1096 M 1096
>KIN16_CAEEL (P34892) Receptor-like tyrosine-protein kinase kin-16 precursor (EC| 2.7.10.1) Length = 495 Score = 67.8 bits (164), Expect = 3e-11 Identities = 48/158 (30%), Positives = 78/158 (49%), Gaps = 7/158 (4%) Frame = -1 Query: 642 KVVDFGVA--FEN---VYCNTLEDDPGTYRWMAPEMCKRKPYGPKVDVYSFGLVLWELVS 478 ++ DFG+A EN +D P RWM+PE + K DV+SFG+ L+E+ + Sbjct: 336 RIADFGMARTHENKSYYIPQKTKDAPVPVRWMSPEAFDTMKFTEKSDVWSFGICLYEIFT 395 Query: 477 -GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIVQ-T 304 G +PY ++ P + Y ++ R P C L LM+ CW +PE RP F+ V+ Sbjct: 396 LGQLPYPDV-PSERIYEYMHSGRRCPQPQHCHVELYDLMKLCWHEKPELRPNFSNCVEYF 454 Query: 303 LENLKTALDRDGTIEKTPTPSCQEAAQEQNKNRLASWI 190 + ++K + + +E EA +N+ +L WI Sbjct: 455 IGHMKKSASK--LLENVDEMLRVEA---ENQRKLEDWI 487
>EPHB3_BRARE (O13147) Ephrin type-B receptor 3 (EC 2.7.10.1) (Tyrosine-protein| kinase receptor ZEK3) (EPH-like kinase 3) (Fragment) Length = 500 Score = 67.8 bits (164), Expect = 3e-11 Identities = 45/126 (35%), Positives = 65/126 (51%), Gaps = 11/126 (8%) Frame = -1 Query: 642 KVVDFGVAFENVYCNTLEDDPGTY----------RWMAPEMCKRKPYGPKVDVYSFGLVL 493 KV DFG++ + + DP TY RW APE + + DV+S+G+V+ Sbjct: 327 KVSDFGLSR---FLDDNSSDP-TYTSSLGGKIPIRWTAPEAIAFRKFTSASDVWSYGIVM 382 Query: 492 WELVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTE 316 WE++S G PY +M+ Q V ++ R P CP L QLM +CW + RP F + Sbjct: 383 WEVMSFGERPYWDMSN-QDVMNAVEQDYRLPPPMDCPAVLHQLMLECWVKERNMRPRFGQ 441 Query: 315 IVQTLE 298 IV TL+ Sbjct: 442 IVSTLD 447
>TIE2_HUMAN (Q02763) Angiopoietin-1 receptor precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (CD202b antigen) Length = 1124 Score = 67.8 bits (164), Expect = 3e-11 Identities = 44/121 (36%), Positives = 65/121 (53%), Gaps = 3/121 (2%) Frame = -1 Query: 645 AKVVDFGVAF-ENVYCN-TLEDDPGTYRWMAPEMCKRKPYGPKVDVYSFGLVLWELVS-G 475 AK+ DFG++ + VY T+ P RWMA E Y DV+S+G++LWE+VS G Sbjct: 978 AKIADFGLSRGQEVYVKKTMGRLP--VRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLG 1035 Query: 474 SIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIVQTLEN 295 PY MT + Y + + R P +C + LM QCW +P +RP F +I+ +L Sbjct: 1036 GTPYCGMTCAE-LYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLNR 1094 Query: 294 L 292 + Sbjct: 1095 M 1095
>ILK1_HUMAN (Q13418) Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59| kDa serine/threonine-protein kinase) (p59ILK) Length = 452 Score = 67.8 bits (164), Expect = 3e-11 Identities = 32/96 (33%), Positives = 55/96 (57%), Gaps = 3/96 (3%) Frame = -1 Query: 567 WMAPEMCKRKPYGPK---VDVYSFGLVLWELVSGSIPYEEMTPLQAAYAVVNKNLRPIVP 397 W+APE ++KP D++SF ++LWELV+ +P+ +++ ++ V + LRP +P Sbjct: 355 WVAPEALQKKPEDTNRRSADMWSFAVLLWELVTREVPFADLSNMEIGMKVALEGLRPTIP 414 Query: 396 SSCPTPLQQLMEQCWSAQPEKRPVFTEIVQTLENLK 289 + +LM+ C + P KRP F IV LE ++ Sbjct: 415 PGISPHVCKLMKICMNEDPAKRPKFDMIVPILEKMQ 450
>MOS_XENLA (P12965) Serine/threonine-protein kinase mos (EC 2.7.11.1)| (pp39-mos) Length = 359 Score = 67.8 bits (164), Expect = 3e-11 Identities = 38/107 (35%), Positives = 59/107 (55%), Gaps = 5/107 (4%) Frame = -1 Query: 603 CNTLEDDPGTYRWMAPEMCKRKPYGPKVDVYSFGLVLWELVSGSIPYEEMTPLQAAYAVV 424 C L GTY APE+ K +P K D+YSF + LW++VS +PY YAVV Sbjct: 227 CTQLRHVGGTYTHRAPELLKGEPVTAKADIYSFAITLWQMVSRELPYTGDRQC-VLYAVV 285 Query: 423 NKNLRP-IVPSSCPT----PLQQLMEQCWSAQPEKRPVFTEIVQTLE 298 +LRP + P T + +++ CW+A+P++RP ++++ LE Sbjct: 286 AYDLRPEMGPLFSHTEEGRAARTIVQSCWAARPQERPNAEQLLERLE 332
>TIE2_MOUSE (Q02858) Angiopoietin-1 receptor precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (HYK) (STK1) (CD202b antigen) Length = 1122 Score = 67.8 bits (164), Expect = 3e-11 Identities = 44/121 (36%), Positives = 65/121 (53%), Gaps = 3/121 (2%) Frame = -1 Query: 645 AKVVDFGVAF-ENVYCN-TLEDDPGTYRWMAPEMCKRKPYGPKVDVYSFGLVLWELVS-G 475 AK+ DFG++ + VY T+ P RWMA E Y DV+S+G++LWE+VS G Sbjct: 976 AKIADFGLSRGQEVYVKKTMGRLP--VRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLG 1033 Query: 474 SIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIVQTLEN 295 PY MT + Y + + R P +C + LM QCW +P +RP F +I+ +L Sbjct: 1034 GTPYCGMTCAE-LYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLNR 1092 Query: 294 L 292 + Sbjct: 1093 M 1093
>TIE2_BRARE (O73791) Tyrosine-protein kinase receptor Tie-2 precursor (EC| 2.7.10.1) Length = 1116 Score = 67.4 bits (163), Expect = 4e-11 Identities = 44/118 (37%), Positives = 66/118 (55%), Gaps = 3/118 (2%) Frame = -1 Query: 645 AKVVDFGVAF-ENVYCN-TLEDDPGTYRWMAPEMCKRKPYGPKVDVYSFGLVLWELVS-G 475 AK+ DFG++ + VY T+ P RWMA E Y DV+S+G++LWE+VS G Sbjct: 970 AKIADFGLSRGQEVYVKKTMGRLP--VRWMAIESLNYSVYTTNSDVWSYGVLLWEVVSLG 1027 Query: 474 SIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIVQTL 301 PY MT + Y + R P +C + +LM+QCW +P +RP F++I+ +L Sbjct: 1028 GTPYCGMTCAEL-YEKLPLGFRLEKPLNCDDEVYELMQQCWREKPFERPSFSQILLSL 1084
>SRC_HUMAN (P12931) Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2)| (p60-Src) (c-Src) (pp60c-src) Length = 535 Score = 67.4 bits (163), Expect = 4e-11 Identities = 46/131 (35%), Positives = 63/131 (48%), Gaps = 9/131 (6%) Frame = -1 Query: 642 KVVDFGVAFENVYCNTLEDDPGTYR--------WMAPEMCKRKPYGPKVDVYSFGLVLWE 487 KV DFG+A +ED+ T R W APE + K DV+SFG++L E Sbjct: 403 KVADFGLA------RLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTE 456 Query: 486 LVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIV 310 L + G +PY M + V + R P CP L LM QCW +PE+RP F + Sbjct: 457 LTTKGRVPYPGMVNREVLDQV-ERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQ 515 Query: 309 QTLENLKTALD 277 LE+ T+ + Sbjct: 516 AFLEDYFTSTE 526
>INSR_HUMAN (P06213) Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220| antigen) [Contains: Insulin receptor alpha subunit; Insulin receptor beta subunit] Length = 1382 Score = 67.4 bits (163), Expect = 4e-11 Identities = 41/120 (34%), Positives = 59/120 (49%), Gaps = 4/120 (3%) Frame = -1 Query: 642 KVVDFGVA---FENVYCNTLEDDPGTYRWMAPEMCKRKPYGPKVDVYSFGLVLWELVS-G 475 K+ DFG+ +E Y RWMAPE K + D++SFG+VLWE+ S Sbjct: 1174 KIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLA 1233 Query: 474 SIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIVQTLEN 295 PY+ ++ Q V++ P +CP + LM CW P+ RP F EIV L++ Sbjct: 1234 EQPYQGLSNEQVLKFVMDGGYLD-QPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLLKD 1292
>KSYK_MOUSE (P48025) Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine| kinase) Length = 629 Score = 67.4 bits (163), Expect = 4e-11 Identities = 43/123 (34%), Positives = 58/123 (47%), Gaps = 6/123 (4%) Frame = -1 Query: 645 AKVVDFGV-----AFENVYCNTLEDDPGTYRWMAPEMCKRKPYGPKVDVYSFGLVLWELV 481 AK+ DFG+ A EN Y +W APE + K DV+SFG+++WE Sbjct: 502 AKISDFGLSKALRADENYY-KAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAF 560 Query: 480 S-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIVQT 304 S G PY M + A++ K R P+ CP + LM CW+ E RP FT + Sbjct: 561 SYGQKPYRGMKGSEVT-AMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFTAVELR 619 Query: 303 LEN 295 L N Sbjct: 620 LRN 622
>YES_HUMAN (P07947) Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2)| (p61-Yes) (c-Yes) Length = 542 Score = 67.4 bits (163), Expect = 4e-11 Identities = 45/131 (34%), Positives = 62/131 (47%), Gaps = 9/131 (6%) Frame = -1 Query: 642 KVVDFGVAFENVYCNTLEDDPGTYR--------WMAPEMCKRKPYGPKVDVYSFGLVLWE 487 K+ DFG+A +ED+ T R W APE + K DV+SFG++ E Sbjct: 410 KIADFGLA------RLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTE 463 Query: 486 LVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIV 310 LV+ G +PY M + V + R P CP L +LM CW P++RP F I Sbjct: 464 LVTKGRVPYPGMVNREVLEQV-ERGYRMPCPQGCPESLHELMNLCWKKDPDERPTFEYIQ 522 Query: 309 QTLENLKTALD 277 LE+ TA + Sbjct: 523 SFLEDYFTATE 533
>RAF1_RAT (P11345) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 67.4 bits (163), Expect = 4e-11 Identities = 43/155 (27%), Positives = 79/155 (50%), Gaps = 10/155 (6%) Frame = -1 Query: 642 KVVDFGVAFENVYCN---TLEDDPGTYRWMAPEMCKRK---PYGPKVDVYSFGLVLWELV 481 K+ DFG+A + +E G+ WMAPE+ + + P+ + DVYS+G+VL+EL+ Sbjct: 483 KIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELM 542 Query: 480 SGSIPYEEMTPLQAAYAVVNKNLR----PIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEI 313 +G +PY + +V + + +CP +++L+ C E+RP+F +I Sbjct: 543 TGELPYSHINNRDQIIFMVGRGYASPDLSRLYKNCPKAMKRLVADCVKKVKEERPLFPQI 602 Query: 312 VQTLENLKTALDRDGTIEKTPTPSCQEAAQEQNKN 208 + ++E L+ +L + PS AA ++ N Sbjct: 603 LSSIELLQHSLPKIN--RSASEPSLHRAAHTEDIN 635
>RAF1_HUMAN (P04049) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 67.4 bits (163), Expect = 4e-11 Identities = 43/155 (27%), Positives = 79/155 (50%), Gaps = 10/155 (6%) Frame = -1 Query: 642 KVVDFGVAFENVYCN---TLEDDPGTYRWMAPEMCKRK---PYGPKVDVYSFGLVLWELV 481 K+ DFG+A + +E G+ WMAPE+ + + P+ + DVYS+G+VL+EL+ Sbjct: 483 KIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELM 542 Query: 480 SGSIPYEEMTPLQAAYAVVNKNLR----PIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEI 313 +G +PY + +V + + +CP +++L+ C E+RP+F +I Sbjct: 543 TGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQI 602 Query: 312 VQTLENLKTALDRDGTIEKTPTPSCQEAAQEQNKN 208 + ++E L+ +L + PS AA ++ N Sbjct: 603 LSSIELLQHSLPKIN--RSASEPSLHRAAHTEDIN 635
>YES_MOUSE (Q04736) Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2)| (p61-Yes) (c-Yes) Length = 540 Score = 67.4 bits (163), Expect = 4e-11 Identities = 45/131 (34%), Positives = 62/131 (47%), Gaps = 9/131 (6%) Frame = -1 Query: 642 KVVDFGVAFENVYCNTLEDDPGTYR--------WMAPEMCKRKPYGPKVDVYSFGLVLWE 487 K+ DFG+A +ED+ T R W APE + K DV+SFG++ E Sbjct: 408 KIADFGLA------RLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTE 461 Query: 486 LVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIV 310 LV+ G +PY M + V + R P CP L +LM CW P++RP F I Sbjct: 462 LVTKGRVPYPGMVNREVLEQV-ERGYRMPCPQGCPESLHELMNLCWKKDPDERPTFEYIQ 520 Query: 309 QTLENLKTALD 277 LE+ TA + Sbjct: 521 SFLEDYFTATE 531
>SRC_MOUSE (P05480) Neuronal proto-oncogene tyrosine-protein kinase Src (EC| 2.7.10.2) (p60-Src) (c-Src) (pp60c-src) Length = 540 Score = 67.4 bits (163), Expect = 4e-11 Identities = 46/131 (35%), Positives = 63/131 (48%), Gaps = 9/131 (6%) Frame = -1 Query: 642 KVVDFGVAFENVYCNTLEDDPGTYR--------WMAPEMCKRKPYGPKVDVYSFGLVLWE 487 KV DFG+A +ED+ T R W APE + K DV+SFG++L E Sbjct: 408 KVADFGLA------RLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTE 461 Query: 486 LVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIV 310 L + G +PY M + V + R P CP L LM QCW +PE+RP F + Sbjct: 462 LTTKGRVPYPGMVNREVLDQV-ERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQ 520 Query: 309 QTLENLKTALD 277 LE+ T+ + Sbjct: 521 AFLEDYFTSTE 531
>EPHB4_MOUSE (P54761) Ephrin type-B receptor 4 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor MDK-2) (Developmental kinase 2) (Tyrosine kinase MYK-1) Length = 987 Score = 67.4 bits (163), Expect = 4e-11 Identities = 42/124 (33%), Positives = 62/124 (50%), Gaps = 7/124 (5%) Frame = -1 Query: 642 KVVDFGVAF---ENVYCNTLEDDPG---TYRWMAPEMCKRKPYGPKVDVYSFGLVLWELV 481 KV DFG++ EN T G + RW APE + + D +S+G+V+WE++ Sbjct: 755 KVSDFGLSRFLEENSSDPTYTSSLGGKISIRWTAPEAIAFRKFTSASDAWSYGIVMWEVM 814 Query: 480 S-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIVQT 304 S G PY +M+ Q + ++ R P CPT L QLM CW RP F ++V Sbjct: 815 SFGERPYWDMSN-QDVINAIEQDYRLPPPPDCPTSLHQLMLDCWQKDRNARPRFPQVVSA 873 Query: 303 LENL 292 L+ + Sbjct: 874 LDKM 877
>BLK_HUMAN (P51451) Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte| kinase) (p55-BLK) Length = 504 Score = 67.4 bits (163), Expect = 4e-11 Identities = 42/133 (31%), Positives = 71/133 (53%), Gaps = 4/133 (3%) Frame = -1 Query: 660 TQKCCAKVVDFGVA--FENVYCNTLEDDPGTYRWMAPEMCKRKPYGPKVDVYSFGLVLWE 487 ++ C K+ DFG+A ++ Y E +W APE + K DV+SFG++L E Sbjct: 368 SEALCCKIADFGLARIIDSEY-TAQEGAKFPIKWTAPEAIHFGVFTIKADVWSFGVLLME 426 Query: 486 LVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQ-LMEQCWSAQPEKRPVFTEI 313 +V+ G +PY M+ + + + R P +CP L + ++ +CW ++PE+RP F + Sbjct: 427 VVTYGRVPYPGMSNPEVIRNL-ERGYRMPRPDTCPPELYRGVIAECWRSRPEERPTFEFL 485 Query: 312 VQTLENLKTALDR 274 LE+ TA +R Sbjct: 486 QSVLEDFYTATER 498
>FGR_HUMAN (P09769) Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2)| (P55-FGR) (C-FGR) Length = 529 Score = 67.4 bits (163), Expect = 4e-11 Identities = 42/130 (32%), Positives = 63/130 (48%), Gaps = 3/130 (2%) Frame = -1 Query: 657 QKCCAKVVDFGVA--FENVYCNTLEDDPGTYRWMAPEMCKRKPYGPKVDVYSFGLVLWEL 484 ++ K+ DFG+A ++ N + +W APE + K DV+SFG++L EL Sbjct: 392 ERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGRFTIKSDVWSFGILLTEL 451 Query: 483 VS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIVQ 307 ++ G IPY M + V P P CP L + MEQ W PE+RP F + Sbjct: 452 ITKGRIPYPGMNKREVLEQVEQGYHMPC-PPGCPASLYEAMEQTWRLDPEERPTFEYLQS 510 Query: 306 TLENLKTALD 277 LE+ T+ + Sbjct: 511 FLEDYFTSAE 520
>INSR_XENLA (Q9PVZ4) Insulin receptor precursor (EC 2.7.10.1) (IR) (Xe-InsR)| (XTK-1b) [Contains: Insulin receptor alpha subunit; Insulin receptor beta subunit] Length = 1362 Score = 67.4 bits (163), Expect = 4e-11 Identities = 41/120 (34%), Positives = 60/120 (50%), Gaps = 4/120 (3%) Frame = -1 Query: 642 KVVDFGVA---FENVYCNTLEDDPGTYRWMAPEMCKRKPYGPKVDVYSFGLVLWELVS-G 475 K+ DFG+ +E Y RWM+PE K + DV+SFG+VLWE+ S Sbjct: 1163 KIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTAFSDVWSFGVVLWEITSLA 1222 Query: 474 SIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIVQTLEN 295 PY+ ++ Q V++ P +CP L LM+ CW P+ RP F EI+ L++ Sbjct: 1223 EQPYQGLSNEQVLKFVMDGGSLDH-PENCPPRLHSLMQMCWQYNPKMRPTFLEIIDMLKD 1281
>MIPR_LYMST (Q25410) Putative molluscan insulin-related peptide(s) receptor| precursor (EC 2.7.10.1) [Contains: Putative molluscan insulin-related peptide(s) receptor alpha chain; Putative molluscan insulin-related peptide(s) receptor beta chain] Length = 1607 Score = 67.4 bits (163), Expect = 4e-11 Identities = 38/128 (29%), Positives = 68/128 (53%), Gaps = 5/128 (3%) Frame = -1 Query: 642 KVVDFGVA---FENVYCNTLEDDPGTYRWMAPEMCKRKPYGPKVDVYSFGLVLWELVS-G 475 K+ DFG+ +E Y RWMAPE K + DV+S+G+V+WE+V+ Sbjct: 1188 KIGDFGMTRDIYETDYYRKGGKGMLPVRWMAPESLKDGVFTSLSDVWSYGVVMWEMVTLA 1247 Query: 474 SIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIVQ-TLE 298 + PY+ ++ + + + + + P +CP + LM+ CW+ +P +RP F I++ L Sbjct: 1248 AQPYQGLSNEEVVKFISDGYIMEL-PENCPNEMAYLMQHCWAKKPNQRPTFKAIIEYLLP 1306 Query: 297 NLKTALDR 274 LK + ++ Sbjct: 1307 KLKPSFEK 1314
>SRC_AVIST (P14085) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 556 Score = 67.4 bits (163), Expect = 4e-11 Identities = 50/153 (32%), Positives = 69/153 (45%), Gaps = 9/153 (5%) Frame = -1 Query: 642 KVVDFGVAFENVYCNTLEDDPGTYR--------WMAPEMCKRKPYGPKVDVYSFGLVLWE 487 KV DFG+A +ED+ T R W APE + K DV+SFG++L E Sbjct: 400 KVADFGLA------RLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTE 453 Query: 486 LVS-GSIPYEEMTPLQAAYAVVNKNLRPIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEIV 310 L + G +PY M + V + R P CP L LM QCW PE+RP F + Sbjct: 454 LTTKGRVPYPGMVNREVLDQV-ERGYRMPCPPECPESLHDLMCQCWRKDPEERPTFEYLQ 512 Query: 309 QTLENLKTALDRDGTIEKTPTPSCQEAAQEQNK 211 LE+ L +K P + A+ +Q + Sbjct: 513 AFLEDYLGILAWTPWEDKQEGPRGETASNKQER 545
>RAF1_MOUSE (Q99N57) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 67.0 bits (162), Expect = 5e-11 Identities = 43/155 (27%), Positives = 79/155 (50%), Gaps = 10/155 (6%) Frame = -1 Query: 642 KVVDFGVAFENVYCN---TLEDDPGTYRWMAPEMCKRK---PYGPKVDVYSFGLVLWELV 481 K+ DFG+A + +E G+ WMAPE+ + + P+ + DVYS+G+VL+EL+ Sbjct: 483 KIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDDNPFSFQSDVYSYGIVLYELM 542 Query: 480 SGSIPYEEMTPLQAAYAVVNKNLR----PIVPSSCPTPLQQLMEQCWSAQPEKRPVFTEI 313 +G +PY + +V + + +CP +++L+ C E+RP+F +I Sbjct: 543 AGELPYAHINNRDQIIFMVGRGYASPDLSRLYKNCPKAMKRLVADCVKKVKEERPLFPQI 602 Query: 312 VQTLENLKTALDRDGTIEKTPTPSCQEAAQEQNKN 208 + ++E L+ +L + PS AA ++ N Sbjct: 603 LSSIELLQHSLPKIN--RSASEPSLHRAAHTEDIN 635 Database: uniprot_sprot.fasta Posted date: May 25, 2006 5:36 PM Number of letters in database: 80,573,946 Number of sequences in database: 219,361 Lambda K H 0.318 0.135 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 100,237,458 Number of Sequences: 219361 Number of extensions: 2121136 Number of successful extensions: 7197 Number of sequences better than 10.0: 500 Number of HSP's better than 10.0 without gapping: 6395 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 6626 length of database: 80,573,946 effective HSP length: 108 effective length of database: 56,882,958 effective search space used: 6655306086 frameshift window, decay const: 50, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)
