>ERG1_PANGI (O48651) Squalene monooxygenase (EC 1.14.99.7) (Squalene epoxidase)|
           (SE)
          Length = 539

 Score =  221 bits (563), Expect = 1e-57
 Identities = 106/124 (85%), Positives = 113/124 (91%)
 Frame = -1

Query: 632 VASTINTLAGALYKVFSASPDKARDEMRQACFDYLSLGGVCSNGPIALLSGLNPRPLSLV 453
           VASTINTLAGALYKVF ASPDKAR EMR ACFDYLSLGG+CS GPIALLSGLNPRP+SL 
Sbjct: 414 VASTINTLAGALYKVFCASPDKARQEMRNACFDYLSLGGICSQGPIALLSGLNPRPISLF 473

Query: 452 AHFFAVAIFGVGRLMLPLPSPKRMWTGARLISGACGIIFPIIKAEGVRQMFFPATVPAYY 273
            HFFAVAI+GVGRL++P PSPKRMW GARLI GA GIIFPIIK+EG+RQMFFPA VPAYY
Sbjct: 474 LHFFAVAIYGVGRLLIPFPSPKRMWLGARLILGASGIIFPIIKSEGLRQMFFPAIVPAYY 533

Query: 272 RAPP 261
           RAPP
Sbjct: 534 RAPP 537

>ERG11_ARATH (O65404) Squalene monooxygenase 1,1 (EC 1.14.99.7) (Squalene|
           epoxidase 1,1) (SE 1,1)
          Length = 516

 Score =  121 bits (303), Expect = 2e-27
 Identities = 56/122 (45%), Positives = 81/122 (66%)
 Frame = -1

Query: 632 VASTINTLAGALYKVFSASPDKARDEMRQACFDYLSLGGVCSNGPIALLSGLNPRPLSLV 453
           +++T+NTL  A  +V  AS D+A++ MRQ C+DYLS GG  ++G +ALL G+NPRP+SL+
Sbjct: 388 MSATVNTLGNAFSQVLVASTDEAKEAMRQGCYDYLSSGGFRTSGMMALLGGMNPRPISLI 447

Query: 452 AHFFAVAIFGVGRLMLPLPSPKRMWTGARLISGACGIIFPIIKAEGVRQMFFPATVPAYY 273
            H  A+ +  +G L+ P PSP R+W   RL   A  ++ P +KAEGV QM FP    AY 
Sbjct: 448 YHLCAITLSSIGHLLSPFPSPLRIWHSLRLFGLAMKMLVPHLKAEGVSQMLFPVNAAAYS 507

Query: 272 RA 267
           ++
Sbjct: 508 KS 509

>ERG12_BRANA (O65726) Squalene monooxygenase 1,2 (EC 1.14.99.7) (Squalene|
           epoxidase 1,2) (SE 1,2)
          Length = 518

 Score =  117 bits (294), Expect = 2e-26
 Identities = 52/122 (42%), Positives = 83/122 (68%)
 Frame = -1

Query: 632 VASTINTLAGALYKVFSASPDKARDEMRQACFDYLSLGGVCSNGPIALLSGLNPRPLSLV 453
           +++T+NTL  + ++V  AS D+A++ MRQ CFDYLS GG  ++G +AL+ G+NPRPLSL 
Sbjct: 390 MSATVNTLGNSFWQVLIASTDEAKEAMRQGCFDYLSSGGFRTSGLMALIGGMNPRPLSLF 449

Query: 452 AHFFAVAIFGVGRLMLPLPSPKRMWTGARLISGACGIIFPIIKAEGVRQMFFPATVPAYY 273
            H F +++  +G+L+ P P+P R+W   RL+  +  ++ P +KAEG+ QM  P    AY 
Sbjct: 450 YHLFVISLSSIGQLLSPFPTPLRVWHSLRLLDLSLKMLVPHLKAEGIGQMLSPTNAAAYR 509

Query: 272 RA 267
           ++
Sbjct: 510 KS 511

>ERG12_ARATH (O65402) Squalene monooxygenase 1,2 (EC 1.14.99.7) (Squalene|
           epoxidase 1,2) (SE 1,2)
          Length = 517

 Score =  117 bits (293), Expect = 3e-26
 Identities = 55/122 (45%), Positives = 81/122 (66%)
 Frame = -1

Query: 632 VASTINTLAGALYKVFSASPDKARDEMRQACFDYLSLGGVCSNGPIALLSGLNPRPLSLV 453
           +++T+NTL  A  +V   S D+A++ MRQ  +DYL  GG  ++G +ALL G+NPRPLSLV
Sbjct: 389 MSATVNTLGNAFSQVLIGSTDEAKEAMRQGVYDYLCSGGFRTSGMMALLGGMNPRPLSLV 448

Query: 452 AHFFAVAIFGVGRLMLPLPSPKRMWTGARLISGACGIIFPIIKAEGVRQMFFPATVPAYY 273
            H  A+ +  +G+L+ P PSP R+W   +L   A  ++ P +KAEGV QM FPA   AY+
Sbjct: 449 YHLCAITLSSIGQLLSPFPSPLRIWHSLKLFGLAMKMLVPNLKAEGVSQMLFPANAAAYH 508

Query: 272 RA 267
           ++
Sbjct: 509 KS 510

>ERG11_BRANA (O65727) Squalene monooxygenase 1,1 (EC 1.14.99.7) (Squalene|
           epoxidase 1,1) (SE 1,1)
          Length = 506

 Score =  104 bits (260), Expect = 2e-22
 Identities = 53/122 (43%), Positives = 74/122 (60%)
 Frame = -1

Query: 632 VASTINTLAGALYKVFSASPDKARDEMRQACFDYLSLGGVCSNGPIALLSGLNPRPLSLV 453
           +++T+NTL  A  +V  AS D+A++ MRQ CFDYLS GG  ++G +ALL G+NPRPLSL+
Sbjct: 389 MSATVNTLGNAFSQVLIASTDEAKEAMRQGCFDYLSSGGFRTSGMMALLGGMNPRPLSLI 448

Query: 452 AHFFAVAIFGVGRLMLPLPSPKRMWTGARLISGACGIIFPIIKAEGVRQMFFPATVPAYY 273
            H   + +  +G+L+ P PSP  +W   RL             AEGV QM  PA   AY 
Sbjct: 449 FHLCGITLSSIGQLLSPFPSPLGIWHSLRLFG-----------AEGVSQMLSPAYAAAYR 497

Query: 272 RA 267
           ++
Sbjct: 498 KS 499

>ERG13_ARATH (O65403) Squalene monooxygenase 2 (EC 1.14.99.7) (Squalene|
           epoxidase 2) (SE 2)
          Length = 516

 Score =  100 bits (250), Expect = 3e-21
 Identities = 46/121 (38%), Positives = 74/121 (61%)
 Frame = -1

Query: 632 VASTINTLAGALYKVFSASPDKARDEMRQACFDYLSLGGVCSNGPIALLSGLNPRPLSLV 453
           +++T+NTLA    +V  A+ D+AR+ MRQ CF+YL+ G   + G + +L G+NP PL+LV
Sbjct: 388 MSATVNTLASIFSQVLVATTDEAREGMRQGCFNYLARGDFKTRGLMTILGGMNPHPLTLV 447

Query: 452 AHFFAVAIFGVGRLMLPLPSPKRMWTGARLISGACGIIFPIIKAEGVRQMFFPATVPAYY 273
            H  A+ +  +G L+ P PSP+R W   R+++ A  ++   +  EG ++M  P    AY 
Sbjct: 448 LHLVAITLTSMGHLLSPFPSPRRFWHSLRILAWALQMLGAHLVDEGFKEMLIPTNAAAYR 507

Query: 272 R 270
           R
Sbjct: 508 R 508

>ERG1_HUMAN (Q14534) Squalene monooxygenase (EC 1.14.99.7) (Squalene epoxidase)|
           (SE)
          Length = 574

 Score = 89.0 bits (219), Expect = 1e-17
 Identities = 46/104 (44%), Positives = 67/104 (64%), Gaps = 3/104 (2%)
 Frame = -1

Query: 620 INTLAGALYKVFSASPDKARDEMRQACFDYLSLGGVCSNGPIALLSGLNPRPLSLVAHFF 441
           +N LA ALY++FSA+ D    ++R+ACF Y  LGG C  GP+ LLS L+P PL+L+ HFF
Sbjct: 466 VNILAQALYELFSATDDSLH-QLRKACFLYFKLGGECVAGPVGLLSVLSPNPLALIGHFF 524

Query: 440 AVAIFGVGRLMLPLP---SPKRMWTGARLISGACGIIFPIIKAE 318
           AVAI+ V       P    P+ + + + ++  AC +IFP+I +E
Sbjct: 525 AVAIYAVYFCFKSEPWITKPRALLSSSAVLYKACSVIFPLIYSE 568

>ERG1_RAT (P52020) Squalene monooxygenase (EC 1.14.99.7) (Squalene epoxidase)|
           (SE)
          Length = 573

 Score = 87.8 bits (216), Expect = 2e-17
 Identities = 45/104 (43%), Positives = 66/104 (63%), Gaps = 3/104 (2%)
 Frame = -1

Query: 620 INTLAGALYKVFSASPDKARDEMRQACFDYLSLGGVCSNGPIALLSGLNPRPLSLVAHFF 441
           +N LA ALY++FSA+ D  R ++R+ACF Y  LGG C  GP+ LLS L+P PL L+ HFF
Sbjct: 465 VNVLAQALYELFSATDDSLR-QLRKACFLYFKLGGECLTGPVGLLSILSPDPLLLIRHFF 523

Query: 440 AVAIFGVGRLMLPLP---SPKRMWTGARLISGACGIIFPIIKAE 318
           +VA++         P    P+ +++   ++  AC IIFP+I +E
Sbjct: 524 SVAVYATYFCFKSEPWATKPRALFSSGAILYKACSIIFPLIYSE 567

>ERG1_MOUSE (P52019) Squalene monooxygenase (EC 1.14.99.7) (Squalene epoxidase)|
           (SE)
          Length = 572

 Score = 85.9 bits (211), Expect = 9e-17
 Identities = 44/104 (42%), Positives = 65/104 (62%), Gaps = 3/104 (2%)
 Frame = -1

Query: 620 INTLAGALYKVFSASPDKARDEMRQACFDYLSLGGVCSNGPIALLSGLNPRPLSLVAHFF 441
           +N LA ALY++FSA+ D    ++R+ACF Y  LGG C  GP+ LLS L+P PL L+ HFF
Sbjct: 464 VNVLAQALYELFSATDDSLH-QLRKACFLYFKLGGECVTGPVGLLSILSPHPLVLIRHFF 522

Query: 440 AVAIFGVGRLMLPLP---SPKRMWTGARLISGACGIIFPIIKAE 318
           +VAI+         P    P+ +++   ++  AC I+FP+I +E
Sbjct: 523 SVAIYATYFCFKSEPWATKPRALFSSGAVLYKACSILFPLIYSE 566

>ERG1_CANAL (Q92206) Squalene monooxygenase (EC 1.14.99.7) (Squalene epoxidase)|
           (SE)
          Length = 496

 Score = 65.5 bits (158), Expect = 1e-10
 Identities = 33/69 (47%), Positives = 43/69 (62%)
 Frame = -1

Query: 626 STINTLAGALYKVFSASPDKARDEMRQACFDYLSLGGVCSNGPIALLSGLNPRPLSLVAH 447
           + INTL+ +LY +F+A     R  +R  CF Y   GG C NGPI LLSG+ P P+ L  H
Sbjct: 389 AVINTLSISLYSLFAADKKPLRI-LRNGCFKYFQRGGECVNGPIGLLSGMLPFPMLLFNH 447

Query: 446 FFAVAIFGV 420
           FF+VA + V
Sbjct: 448 FFSVAFYSV 456

>ERG1_SCHPO (Q9C1W3) Probable squalene monooxygenase (EC 1.14.99.7) (Squalene|
           epoxidase) (SE)
          Length = 457

 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 37/104 (35%), Positives = 56/104 (53%), Gaps = 3/104 (2%)
 Frame = -1

Query: 620 INTLAGALYKVFSASPDKARDEMRQACFDYLSLGGVCSNGPIALLSGLNPRPLSLVAHFF 441
           IN L+ ALYK+F+   ++    +   C DY   GG C  GPI LL GL+  P  L+ HF+
Sbjct: 352 INVLSIALYKLFTPK-NRYMKALESGCIDYFKRGGNCVEGPIRLLGGLDHSPSHLIGHFY 410

Query: 440 AVAIFGVGRLMLPLPS---PKRMWTGARLISGACGIIFPIIKAE 318
           AV ++G+ + +L  P+   P R+     +   A  +I P I +E
Sbjct: 411 AVCLYGIYQYVLSGPALLMPVRIIESLLIFLQASLVIIPYILSE 454

>ERG1_YEAST (P32476) Squalene monooxygenase (EC 1.14.99.7) (Squalene epoxidase)|
           (SE)
          Length = 496

 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 30/69 (43%), Positives = 42/69 (60%)
 Frame = -1

Query: 626 STINTLAGALYKVFSASPDKARDEMRQACFDYLSLGGVCSNGPIALLSGLNPRPLSLVAH 447
           S IN L+ ALY +F+A  D  +  +++ CF Y   GG C N P+  LSG+ P+PL L   
Sbjct: 389 SVINVLSVALYSLFAADSDNLK-ALQKGCFKYFQRGGDCVNKPVEFLSGVLPKPLQLTRV 447

Query: 446 FFAVAIFGV 420
           FFAVA + +
Sbjct: 448 FFAVAFYTI 456

>ERG1_CANGA (O13306) Squalene monooxygenase (EC 1.14.99.7) (Squalene epoxidase)|
           (SE)
          Length = 489

 Score = 55.5 bits (132), Expect = 1e-07
 Identities = 27/69 (39%), Positives = 42/69 (60%)
 Frame = -1

Query: 626 STINTLAGALYKVFSASPDKARDEMRQACFDYLSLGGVCSNGPIALLSGLNPRPLSLVAH 447
           + +N L+ +LY +F+A   K    +++ CF Y   GG C N P+A L+G+ P+PL L   
Sbjct: 382 AVVNVLSISLYSLFAAD-SKNLKALQKGCFKYFQRGGDCVNLPVAFLAGVLPKPLLLTRV 440

Query: 446 FFAVAIFGV 420
           FFAVA + +
Sbjct: 441 FFAVAFYTI 449

>ERG1_ASHGO (Q75F69) Squalene monooxygenase (EC 1.14.99.7) (Squalene epoxidase)|
           (SE)
          Length = 497

 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 35/104 (33%), Positives = 53/104 (50%), Gaps = 3/104 (2%)
 Frame = -1

Query: 629 ASTINTLAGALYKVFSASPDKARDEMRQACFDYLSLGGVCSNGPIALLSGLNPRPLSLVA 450
           A  INTL+ ALY +F+A     + ++++ CF+YL  G      PI+ LSG+ P P  L  
Sbjct: 389 ACVINTLSIALYSLFAADSYYLK-KLQKGCFEYLGRGEDWVRQPISFLSGVLPSPYLLTK 447

Query: 449 HFFAVAIFGV---GRLMLPLPSPKRMWTGARLISGACGIIFPII 327
            FF VA++ V    R   PL     ++ G  +I  A  +  P +
Sbjct: 448 VFFTVALYSVLINFRGRTPLGFLLAIYEGFAIIFTAAKVFTPFL 491

>HR4_DROME (Q9W539) Hormone receptor 4 (dHR4)|
          Length = 1518

 Score = 32.7 bits (73), Expect = 0.92
 Identities = 29/96 (30%), Positives = 43/96 (44%), Gaps = 2/96 (2%)
 Frame = +1

Query: 244 LQNSASGGAR*YAGTVAGKNICLTPSALIIGKM--IPHAPEINLAPVHIRLGEGRGSISR 417
           L  SA G A   A  VA + +    +A I G    +   P  NL PV +  G G GS+  
Sbjct: 626 LMQSAGGAAAAAAAAVAAQRMVCFSNARINGVKPEVIGGPLGNLRPVGVGGGNGSGSVQC 685

Query: 418 PTPKIATAKKCATKLNGRGLRPESRAMGPFEQTPPR 525
           P+P  +++   +       L P++ +     QTPPR
Sbjct: 686 PSPHPSSSSSSSQ------LSPQTPS-----QTPPR 710

>DSBB_RALSO (Q8XZM2) Disulfide bond formation protein B (Disulfide|
           oxidoreductase)
          Length = 159

 Score = 30.0 bits (66), Expect = 6.0
 Identities = 20/50 (40%), Positives = 27/50 (54%), Gaps = 1/50 (2%)
 Frame = -1

Query: 488 LSGLNPRPLSLVAHFFAVAIFGVGRLMLPLPSPKRM-WTGARLISGACGI 342
           + GL P PL ++  F  V I GV  L+  L S  R+ W G  ++SG  GI
Sbjct: 29  VEGLQPCPLCVLQRFAFVGI-GVFSLLAALSSATRLLWHGLGMLSGLGGI 77

>IPPD_MOUSE (Q60829) Dopamine- and cAMP-regulated neuronal phosphoprotein|
           (DARPP-32)
          Length = 194

 Score = 29.6 bits (65), Expect = 7.8
 Identities = 14/37 (37%), Positives = 21/37 (56%)
 Frame = +1

Query: 457 KLNGRGLRPESRAMGPFEQTPPRLK*SKHAWRISSLA 567
           + +G G  P+S+   P   TPP LK  +H   IS+L+
Sbjct: 56  RTSGEGHHPKSKRPNPCAYTPPSLKAVQHLQTISNLS 92


  Database: uniprot_sprot.fasta
    Posted date:  May 25, 2006  5:36 PM
  Number of letters in database: 80,573,946
  Number of sequences in database:  219,361
  
Lambda     K      H
   0.318    0.135    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 94,950,267
Number of Sequences: 219361
Number of extensions: 2050088
Number of successful extensions: 5137
Number of sequences better than 10.0: 17
Number of HSP's better than 10.0 without gapping: 4969
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5127
length of database: 80,573,946
effective HSP length: 107
effective length of database: 57,102,319
effective search space used: 5881538857
frameshift window, decay const: 50,  0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)