>AP2M_DICDI (P54672) AP-2 complex subunit mu (Clathrin coat assembly protein|
           AP50) (Clathrin coat-associated protein AP50) (Plasma
           membrane adaptor AP-2 50 kDa protein) (Clathrin assembly
           protein complex 2 medium chain)
          Length = 439

 Score =  147 bits (371), Expect = 3e-35
 Identities = 73/135 (54%), Positives = 95/135 (70%), Gaps = 1/135 (0%)
 Frame = -3

Query: 661 TRMEINVKVKSVFGXXMFALGVVVKVPVPKQTAKTSFQTTSGKAKYNASIDSLVWKIRKF 482
           TR+E +V VKS F   MF   V V +P PK TA       +GKAKY    D+++W+IR+F
Sbjct: 304 TRLECSVTVKSNFSSKMFGANVKVIIPTPKNTAVCKIVVAAGKAKYMPEQDAIIWRIRRF 363

Query: 481 PGQTEATMSAEVELISTMG-EKKLANRPPIQMEFQVPMFTASGLRVRFLKVWEKSGYNTV 305
           PG TE T+ AEVEL++++  +KK  +RPPI MEFQV MFTASG  VRFLKV EKS Y  +
Sbjct: 364 PGDTEFTLRAEVELMASVNLDKKAWSRPPISMEFQVTMFTASGFSVRFLKVVEKSNYTPI 423

Query: 304 EWVRYITRAGSYEIR 260
           +WVRY+T+AG+Y+ R
Sbjct: 424 KWVRYLTKAGTYQNR 438

>AP2M1_RAT (P84092) AP-2 complex subunit mu-1 (Adaptin mu-1) (AP-2 mu-2 chain)|
           (Clathrin coat assembly protein AP50) (Clathrin
           coat-associated protein AP50) (Plasma membrane adaptor
           AP-2 50 kDa protein) (Clathrin assembly protein complex
           2 medium chain)
          Length = 435

 Score =  120 bits (300), Expect = 5e-27
 Identities = 63/139 (45%), Positives = 91/139 (65%), Gaps = 4/139 (2%)
 Frame = -3

Query: 661 TRMEINVKVKSVFGXXMFALGVVVKVPVPKQTAKTSFQTTSGKAKYNASIDSLVWKIRKF 482
           T++E+ V +KS F   + A  + V++P P  T+        GKAKY AS +++VWKI++ 
Sbjct: 299 TKLEVKVVIKSNFKPSLLAQKIEVRIPTPLNTSGVQVICMKGKAKYKASENAIVWKIKRM 358

Query: 481 PGQTEATMSAEVELISTMGEKKLANRPPIQMEFQVPMFTASGLRVRFLKVWEK----SGY 314
            G  E+ +SAE+EL+ T  +KK A RPPI M F+VP F  SGL+VR+LKV+E     S +
Sbjct: 359 AGMKESQISAEIELLPTNDKKKWA-RPPISMNFEVP-FAPSGLKVRYLKVFEPKLNYSDH 416

Query: 313 NTVEWVRYITRAGSYEIRC 257
           + ++WVRYI R+G YE RC
Sbjct: 417 DVIKWVRYIGRSGIYETRC 435

>AP2M1_MOUSE (P84091) AP-2 complex subunit mu-1 (Adaptin mu-1) (AP-2 mu-2 chain)|
           (Clathrin coat assembly protein AP50) (Clathrin
           coat-associated protein AP50) (Plasma membrane adaptor
           AP-2 50 kDa protein) (Clathrin assembly protein complex
           2 medium chain)
          Length = 435

 Score =  120 bits (300), Expect = 5e-27
 Identities = 63/139 (45%), Positives = 91/139 (65%), Gaps = 4/139 (2%)
 Frame = -3

Query: 661 TRMEINVKVKSVFGXXMFALGVVVKVPVPKQTAKTSFQTTSGKAKYNASIDSLVWKIRKF 482
           T++E+ V +KS F   + A  + V++P P  T+        GKAKY AS +++VWKI++ 
Sbjct: 299 TKLEVKVVIKSNFKPSLLAQKIEVRIPTPLNTSGVQVICMKGKAKYKASENAIVWKIKRM 358

Query: 481 PGQTEATMSAEVELISTMGEKKLANRPPIQMEFQVPMFTASGLRVRFLKVWEK----SGY 314
            G  E+ +SAE+EL+ T  +KK A RPPI M F+VP F  SGL+VR+LKV+E     S +
Sbjct: 359 AGMKESQISAEIELLPTNDKKKWA-RPPISMNFEVP-FAPSGLKVRYLKVFEPKLNYSDH 416

Query: 313 NTVEWVRYITRAGSYEIRC 257
           + ++WVRYI R+G YE RC
Sbjct: 417 DVIKWVRYIGRSGIYETRC 435

>AP2M1_HUMAN (Q96CW1) AP-2 complex subunit mu-1 (Adaptin mu-1) (AP-2 mu-2 chain)|
           (Clathrin coat assembly protein AP50) (Clathrin
           coat-associated protein AP50) (Plasma membrane adaptor
           AP-2 50 kDa protein) (HA2 50 kDa subunit) (Clathrin
           assembly protein co
          Length = 435

 Score =  120 bits (300), Expect = 5e-27
 Identities = 63/139 (45%), Positives = 91/139 (65%), Gaps = 4/139 (2%)
 Frame = -3

Query: 661 TRMEINVKVKSVFGXXMFALGVVVKVPVPKQTAKTSFQTTSGKAKYNASIDSLVWKIRKF 482
           T++E+ V +KS F   + A  + V++P P  T+        GKAKY AS +++VWKI++ 
Sbjct: 299 TKLEVKVVIKSNFKPSLLAQKIEVRIPTPLNTSGVQVICMKGKAKYKASENAIVWKIKRM 358

Query: 481 PGQTEATMSAEVELISTMGEKKLANRPPIQMEFQVPMFTASGLRVRFLKVWEK----SGY 314
            G  E+ +SAE+EL+ T  +KK A RPPI M F+VP F  SGL+VR+LKV+E     S +
Sbjct: 359 AGMKESQISAEIELLPTNDKKKWA-RPPISMNFEVP-FAPSGLKVRYLKVFEPKLNYSDH 416

Query: 313 NTVEWVRYITRAGSYEIRC 257
           + ++WVRYI R+G YE RC
Sbjct: 417 DVIKWVRYIGRSGIYETRC 435

>AP2M_CAEEL (P35603) AP-2 complex subunit mu (Clathrin coat assembly protein|
           AP50) (Clathrin coat-associated protein AP50) (Plasma
           membrane adaptor AP-2 50 kDa protein) (Clathrin assembly
           protein complex 2 medium chain) (Dumpy protein 23)
          Length = 441

 Score =  119 bits (299), Expect = 6e-27
 Identities = 63/139 (45%), Positives = 90/139 (64%), Gaps = 5/139 (3%)
 Frame = -3

Query: 658 RMEINVKVKSVFGXXMFALGVVVKVPVPKQTAKTSFQTTSGKAKYNASIDSLVWKIRKFP 479
           +ME+ V VKS F   + A  + V++P P  T+        GKAKY A  +++VWKI++  
Sbjct: 304 KMEVKVVVKSNFKPSLLAQKLEVRIPTPPNTSGVQLICMKGKAKYKAGENAIVWKIKRMA 363

Query: 478 GQTEATMSAEVELISTMG-EKKLANRPPIQMEFQVPMFTASGLRVRFLKVWEK----SGY 314
           G  E+ +SAE++L+ST   EKK  NRPP+ M F+VP F  SGL+VR+LKV+E     S +
Sbjct: 364 GMKESQISAEIDLLSTGNVEKKKWNRPPVSMNFEVP-FAPSGLKVRYLKVFEPKLNYSDH 422

Query: 313 NTVEWVRYITRAGSYEIRC 257
           + ++WVRYI R+G YE RC
Sbjct: 423 DVIKWVRYIGRSGLYETRC 441

>AP1M2_MOUSE (Q9WVP1) AP-1 complex subunit mu-2 (Adaptor-related protein complex|
           1 mu-2 subunit) (Mu-adaptin 2) (Adaptor protein complex
           AP-1 mu-2 subunit) (Golgi adaptor HA1/AP1 adaptin mu-2
           subunit) (Clathrin assembly protein assembly protein
           complex 1
          Length = 423

 Score =  116 bits (290), Expect = 7e-26
 Identities = 58/134 (43%), Positives = 83/134 (61%)
 Frame = -3

Query: 661 TRMEINVKVKSVFGXXMFALGVVVKVPVPKQTAKTSFQTTSGKAKYNASIDSLVWKIRKF 482
           +R+EI VK K  F     A GV + VPVP       F+T+ G AKY    + ++W I+ F
Sbjct: 289 SRVEIMVKAKGQFKKQSVANGVEISVPVPSDADSPRFKTSVGSAKYVPEKNVVIWSIKSF 348

Query: 481 PGQTEATMSAEVELISTMGEKKLANRPPIQMEFQVPMFTASGLRVRFLKVWEKSGYNTVE 302
           PG  E  M A   L S   E+ +  RPPI ++F++P FT SG++VR++K+ EKSGY  + 
Sbjct: 349 PGGKEYLMRAHFGLPSVETEE-VEGRPPIGVKFEIPYFTVSGIQVRYMKIIEKSGYQALP 407

Query: 301 WVRYITRAGSYEIR 260
           WVRYIT++G Y++R
Sbjct: 408 WVRYITQSGDYQLR 421

>AP1M2_HUMAN (Q9Y6Q5) AP-1 complex subunit mu-2 (Adaptor-related protein complex|
           1 mu-2 subunit) (Mu-adaptin 2) (Adaptor protein complex
           AP-1 mu-2 subunit) (Golgi adaptor HA1/AP1 adaptin mu-2
           subunit) (Clathrin assembly protein assembly protein
           complex 1
          Length = 423

 Score =  116 bits (290), Expect = 7e-26
 Identities = 58/134 (43%), Positives = 83/134 (61%)
 Frame = -3

Query: 661 TRMEINVKVKSVFGXXMFALGVVVKVPVPKQTAKTSFQTTSGKAKYNASIDSLVWKIRKF 482
           +R+EI VK K  F     A GV + VPVP       F+T+ G AKY    + ++W I+ F
Sbjct: 289 SRVEIMVKAKGQFKKQSVANGVEISVPVPSDADSPRFKTSVGSAKYVPERNVVIWSIKSF 348

Query: 481 PGQTEATMSAEVELISTMGEKKLANRPPIQMEFQVPMFTASGLRVRFLKVWEKSGYNTVE 302
           PG  E  M A   L S   E+ +  RPPI ++F++P FT SG++VR++K+ EKSGY  + 
Sbjct: 349 PGGKEYLMRAHFGLPSVEKEE-VEGRPPIGVKFEIPYFTVSGIQVRYMKIIEKSGYQALP 407

Query: 301 WVRYITRAGSYEIR 260
           WVRYIT++G Y++R
Sbjct: 408 WVRYITQSGDYQLR 421

>AP1M_CAEEL (P35602) AP-1 complex subunit mu (Clathrin coat assembly protein|
           AP47) (Clathrin coat-associated protein AP47) (Golgi
           adaptor AP-1 47 kDa protein) (HA1 47 kDa subunit)
           (Clathrin assembly protein assembly protein complex 1
           medium chain) (Uncoor
          Length = 422

 Score =  115 bits (288), Expect = 1e-25
 Identities = 56/134 (41%), Positives = 81/134 (60%)
 Frame = -3

Query: 661 TRMEINVKVKSVFGXXMFALGVVVKVPVPKQTAKTSFQTTSGKAKYNASIDSLVWKIRKF 482
           +R+   +K KS F     A  V + +PVP       F+T+ G  KY     + VW I+ F
Sbjct: 288 SRVSFIIKAKSQFKRRSTANNVEIIIPVPSDADSPKFKTSIGSVKYTPEQSAFVWTIKNF 347

Query: 481 PGQTEATMSAEVELISTMGEKKLANRPPIQMEFQVPMFTASGLRVRFLKVWEKSGYNTVE 302
           PG  E  ++A + L S M E+    RPPI+++F++P FT SG++VR+LK+ EKSGY  + 
Sbjct: 348 PGGKEYLLTAHLSLPSVMSEES-EGRPPIKVKFEIPYFTTSGIQVRYLKIIEKSGYQALP 406

Query: 301 WVRYITRAGSYEIR 260
           WVRYIT+ G YE+R
Sbjct: 407 WVRYITQNGEYEMR 420

>AP1M1_MOUSE (P35585) AP-1 complex subunit mu-1 (Adaptor-related protein complex|
           1 mu-1 subunit) (Mu-adaptin 1) (Adaptor protein complex
           AP-1 mu-1 subunit) (Golgi adaptor HA1/AP1 adaptin mu-1
           subunit) (Clathrin assembly protein assembly protein
           complex 1
          Length = 422

 Score =  112 bits (280), Expect = 1e-24
 Identities = 56/134 (41%), Positives = 78/134 (58%)
 Frame = -3

Query: 661 TRMEINVKVKSVFGXXMFALGVVVKVPVPKQTAKTSFQTTSGKAKYNASIDSLVWKIRKF 482
           +R+E  VK KS F     A  V + +PVP       F+TT G  K+      +VW ++ F
Sbjct: 288 SRIEYMVKAKSQFKRRSTANNVEIHIPVPNDADSPKFKTTVGSVKWVPENSEIVWSVKSF 347

Query: 481 PGQTEATMSAEVELISTMGEKKLANRPPIQMEFQVPMFTASGLRVRFLKVWEKSGYNTVE 302
           PG  E  M A   L S   E K   +PPI ++F++P FT SG++VR+LK+ EKSGY  + 
Sbjct: 348 PGGKEYLMRAHFGLPSVEAEDK-EGKPPISVKFEIPYFTTSGIQVRYLKIIEKSGYQALP 406

Query: 301 WVRYITRAGSYEIR 260
           WVRYIT+ G Y++R
Sbjct: 407 WVRYITQNGDYQLR 420

>AP1M1_HUMAN (Q9BXS5) AP-1 complex subunit mu-1 (Adaptor-related protein complex|
           1 mu-1 subunit) (Mu-adaptin 1) (Adaptor protein complex
           AP-1 mu-1 subunit) (Golgi adaptor HA1/AP1 adaptin mu-1
           subunit) (Clathrin assembly protein assembly protein
           complex 1
          Length = 422

 Score =  112 bits (280), Expect = 1e-24
 Identities = 56/134 (41%), Positives = 78/134 (58%)
 Frame = -3

Query: 661 TRMEINVKVKSVFGXXMFALGVVVKVPVPKQTAKTSFQTTSGKAKYNASIDSLVWKIRKF 482
           +R+E  +K KS F     A  V + +PVP       F+TT G  K+      +VW I+ F
Sbjct: 288 SRIEYMIKAKSQFKRRSTANNVEIHIPVPNDADSPKFKTTVGSVKWVPENSEIVWSIKSF 347

Query: 481 PGQTEATMSAEVELISTMGEKKLANRPPIQMEFQVPMFTASGLRVRFLKVWEKSGYNTVE 302
           PG  E  M A   L S   E K   +PPI ++F++P FT SG++VR+LK+ EKSGY  + 
Sbjct: 348 PGGKEYLMRAHFGLPSVEAEDK-EGKPPISVKFEIPYFTTSGIQVRYLKIIEKSGYQALP 406

Query: 301 WVRYITRAGSYEIR 260
           WVRYIT+ G Y++R
Sbjct: 407 WVRYITQNGDYQLR 420

>AP1M1_SCHPO (Q9HFE5) AP-1 complex subunit mu-1 (Mu(1)-adaptin) (Clathrin|
           assembly protein complex 1 medium chain)
          Length = 426

 Score = 97.8 bits (242), Expect = 3e-20
 Identities = 53/137 (38%), Positives = 82/137 (59%), Gaps = 3/137 (2%)
 Frame = -3

Query: 661 TRMEINVKVKSVFGXXMFALGVVVKVPVPKQTAKTSFQTTSGKAKYNASIDSLVWKIRKF 482
           +R+E  VK K+ F     A  V + +PVP+      FQT++G  +Y     ++VW I+KF
Sbjct: 289 SRIEFMVKAKAQFKKRCIANNVQIIIPVPEDADSPRFQTSNGHVQYAPEQAAMVWNIKKF 348

Query: 481 PGQTEATMSAEVELISTMGEK-KLANRPPIQMEFQVPMFTASGLRVRFLKVWE-KSGYNT 308
            G  E  M AE+ L S   E  ++  + P+Q++F +P FT SG++VR+LK+ E K  Y+ 
Sbjct: 349 AGGKEFFMRAEMGLPSVKNEDIQVQKKRPVQLKFAIPYFTTSGIQVRYLKITEPKLNYHA 408

Query: 307 VEWVRYITRAGS-YEIR 260
           + WVRY+T+ G+ Y IR
Sbjct: 409 MPWVRYVTQNGTEYSIR 425

>AP2M_SCHPO (Q09718) AP-2 complex subunit mu (Probable clathrin coat assembly|
           protein AP50) (Clathrin coat-associated protein AP50)
           (Plasma membrane adaptor AP-2 50 kDa protein) (Clathrin
           assembly protein complex 2 medium chain)
          Length = 446

 Score = 95.1 bits (235), Expect = 2e-19
 Identities = 50/112 (44%), Positives = 73/112 (65%), Gaps = 2/112 (1%)
 Frame = -3

Query: 589 KVPVPKQTAKTSFQTTSGKAKYNASIDSLVWKIRKFPGQTEATMSAEVELISTMGEKKLA 410
           ++PVP    K + +   GKA Y  S + + WKI +F G+TE    AEVEL +T  ++  A
Sbjct: 335 RIPVPTNVVKANPRVNRGKAGYEPSENIINWKIPRFLGETELIFYAEVELSNTTNQQIWA 394

Query: 409 NRPPIQMEFQVPMFTASGLRVRFLKVWEKSG--YNTVEWVRYITRAGSYEIR 260
            +PPI ++F + MFT+SGL V++L+V E S   Y +++WVRY TRAG+ EIR
Sbjct: 395 -KPPISLDFNILMFTSSGLHVQYLRVSEPSNSKYKSIKWVRYSTRAGTCEIR 445

>AP1M1_YEAST (Q00776) AP-1 complex subunit mu-1 (Mu(1)-adaptin) (Clathrin|
           assembly protein complex 1 medium chain) (Clathrin coat
           assembly protein AP54) (Clathrin coat-associated protein
           AP54) (Golgi adaptor AP-1 54 kDa protein) (HA1 54 kDa
           subunit)
          Length = 475

 Score = 92.8 bits (229), Expect = 8e-19
 Identities = 55/146 (37%), Positives = 83/146 (56%), Gaps = 12/146 (8%)
 Frame = -3

Query: 661 TRMEINVKVKSVFGXXMFALGVVVKVPVPKQTAKTSFQTTSGKAKYNASIDSLVWKIRKF 482
           +R+EI+ K K+       A  V + +PVP      +F+ + G  KY     +++WKIR F
Sbjct: 328 SRIEIHCKAKAQIKRKSTATNVEILIPVPDDADTPTFKYSHGSLKYVPEKSAILWKIRSF 387

Query: 481 PGQTEATMSAEVELISTM----GEKKLAN------RPPIQMEFQVPMFTASGLRVRFLKV 332
           PG  E +MSAE+ L S      G + +        + P+Q++FQ+P FT SG++VR+LK+
Sbjct: 388 PGGKEYSMSAELGLPSISNNEDGNRTMPKSNAEILKGPVQIKFQIPYFTTSGIQVRYLKI 447

Query: 331 WE-KSGYNTVEWVRYITRAG-SYEIR 260
            E K  Y +  WVRYIT++G  Y IR
Sbjct: 448 NEPKLQYKSYPWVRYITQSGDDYTIR 473

>AP2M_YEAST (Q99186) AP-2 complex subunit mu (Clathrin coat assembly protein|
           AP50) (Clathrin coat-associated protein AP50) (Plasma
           membrane adaptor AP-2 50 kDa protein) (Clathrin assembly
           protein complex 2 medium chain) (Adaptin medium chain
           APM4)
          Length = 491

 Score = 92.8 bits (229), Expect = 8e-19
 Identities = 48/135 (35%), Positives = 79/135 (58%), Gaps = 3/135 (2%)
 Frame = -3

Query: 655 MEINVKVKSVFGXXMFALGVVVKVPVPKQTAKTSFQTTSGKAKYNASIDSLVWKIRKFPG 476
           ++  + +KS+F   + A  VV+ +PVP  T       ++G  K+    ++++W+  K+ G
Sbjct: 356 IDYRITLKSLFPGKLSAKDVVLHIPVPPSTVDCKISVSNGHCKFVPEENAMIWRFNKYNG 415

Query: 475 QTEATMSAEVELISTMGEKKLA--NRPPIQMEFQVPMFTASGLRVRFLKVWEK-SGYNTV 305
            TE T+SA     S   +  L    RPPI +EF+V MF+ SGL VR+  +  K S +  V
Sbjct: 416 LTENTLSAVTVSTSDTTQLNLQQWTRPPISLEFEVMMFSNSGLVVRYFTISGKDSKHRAV 475

Query: 304 EWVRYITRAGSYEIR 260
           +W++YI++AGSYE+R
Sbjct: 476 KWIKYISKAGSYEVR 490

>AP3M1_RAT (P53676) AP-3 complex subunit mu-1 (Adapter-related protein complex|
           3 mu-1 subunit) (Mu-adaptin 3A) (AP-3 adapter complex
           mu3A subunit) (Clathrin coat assembly protein AP47
           homolog 1) (Clathrin coat-associated protein AP47
           homolog 1) (Golgi ada
          Length = 418

 Score = 53.1 bits (126), Expect = 7e-07
 Identities = 35/133 (26%), Positives = 61/133 (45%)
 Frame = -3

Query: 658 RMEINVKVKSVFGXXMFALGVVVKVPVPKQTAKTSFQTTSGKAKYNASIDSLVWKIRKFP 479
           R +I +  K   G  +   G+ V V +PK     +   T G   ++     L W + K  
Sbjct: 290 RFDITIGPKQNMGKTIE--GITVTVHMPKVVLNMNLTPTQGSYTFDPVTKVLAWDVGKIT 347

Query: 478 GQTEATMSAEVELISTMGEKKLANRPPIQMEFQVPMFTASGLRVRFLKVWEKSGYNTVEW 299
            Q   ++   V L S  G  K    P + ++F++     SGL+V  L ++ +  Y   + 
Sbjct: 348 PQKLPSLKGLVNLQS--GAPKPEENPNLNIQFKIQQLAISGLKVNRLDMYGEK-YKPFKG 404

Query: 298 VRYITRAGSYEIR 260
           V+YIT+AG +++R
Sbjct: 405 VKYITKAGKFQVR 417

>AP3M1_HUMAN (Q9Y2T2) AP-3 complex subunit mu-1 (Adapter-related protein complex|
           3 mu-1 subunit) (Mu-adaptin 3A) (AP-3 adapter complex
           mu3A subunit)
          Length = 418

 Score = 53.1 bits (126), Expect = 7e-07
 Identities = 34/133 (25%), Positives = 61/133 (45%)
 Frame = -3

Query: 658 RMEINVKVKSVFGXXMFALGVVVKVPVPKQTAKTSFQTTSGKAKYNASIDSLVWKIRKFP 479
           R +I +  K   G  +   G+ V V +PK     +   T G   ++     L W + K  
Sbjct: 290 RFDITIGPKQNMGKTIE--GITVTVHMPKVVLNMNLTPTQGSYTFDPVTKVLTWDVGKIT 347

Query: 478 GQTEATMSAEVELISTMGEKKLANRPPIQMEFQVPMFTASGLRVRFLKVWEKSGYNTVEW 299
            Q   ++   V L S  G  K    P + ++F++     SGL+V  L ++ +  Y   + 
Sbjct: 348 PQKLPSLKGLVNLQS--GAPKPEENPSLNIQFKIQQLAISGLKVNRLDMYGEK-YKPFKG 404

Query: 298 VRYITRAGSYEIR 260
           V+Y+T+AG +++R
Sbjct: 405 VKYVTKAGKFQVR 417

>AP3M1_MOUSE (Q9JKC8) AP-3 complex subunit mu-1 (Adapter-related protein complex|
           3 mu-1 subunit) (Mu-adaptin 3A) (AP-3 adapter complex
           mu3A subunit)
          Length = 418

 Score = 52.8 bits (125), Expect = 9e-07
 Identities = 34/133 (25%), Positives = 61/133 (45%)
 Frame = -3

Query: 658 RMEINVKVKSVFGXXMFALGVVVKVPVPKQTAKTSFQTTSGKAKYNASIDSLVWKIRKFP 479
           R +I +  K   G  +   G+ V V +PK     +   T G   ++     L W + K  
Sbjct: 290 RFDITIGPKQNMGKTIE--GITVTVHMPKVVLNMNLTPTQGSYTFDPVTKVLAWDVGKIT 347

Query: 478 GQTEATMSAEVELISTMGEKKLANRPPIQMEFQVPMFTASGLRVRFLKVWEKSGYNTVEW 299
            Q   ++   V L S  G  K    P + ++F++     SGL+V  L ++ +  Y   + 
Sbjct: 348 PQKLPSLKGLVNLQS--GAPKPEENPNLNIQFKIQQLAISGLKVNRLDMYGEK-YKPFKG 404

Query: 298 VRYITRAGSYEIR 260
           V+Y+T+AG +++R
Sbjct: 405 VKYVTKAGKFQVR 417

>AP3M2_MOUSE (Q8R2R9) AP-3 complex subunit mu-2 (Adapter-related protein complex|
           3 mu-2 subunit) (Clathrin coat assembly protein AP47
           homolog 2) (Clathrin coat-associated protein AP47
           homolog 2) (Golgi adaptor AP-1 47 kDa protein homolog 2)
           (HA1 47 kDa su
          Length = 418

 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 34/133 (25%), Positives = 61/133 (45%)
 Frame = -3

Query: 658 RMEINVKVKSVFGXXMFALGVVVKVPVPKQTAKTSFQTTSGKAKYNASIDSLVWKIRKFP 479
           R EI V  K   G  +   GV+V   +PK     S   + G   ++     L W + K  
Sbjct: 290 RFEITVGPKQTMGKTIE--GVIVTSQMPKGVLNMSLTPSQGTHTFDPVTKMLSWDVGKIN 347

Query: 478 GQTEATMSAEVELISTMGEKKLANRPPIQMEFQVPMFTASGLRVRFLKVWEKSGYNTVEW 299
            Q   ++   + L   +G  K    P I ++F++     SGL+V  L ++ +  Y   + 
Sbjct: 348 PQKLPSLKGTMGL--QVGASKPDENPTINLQFKIQQLAISGLKVNRLDMYGEK-YKPFKG 404

Query: 298 VRYITRAGSYEIR 260
           ++Y+T+AG +++R
Sbjct: 405 IKYMTKAGKFQVR 417

>AP3M2_RAT (P53678) AP-3 complex subunit mu-2 (Adapter-related protein complex|
           3 mu-2 subunit) (Clathrin coat assembly protein AP47
           homolog 2) (Clathrin coat-associated protein AP47
           homolog 2) (Golgi adaptor AP-1 47 kDa protein homolog 2)
           (HA1 47 kDa subu
          Length = 418

 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 34/133 (25%), Positives = 60/133 (45%)
 Frame = -3

Query: 658 RMEINVKVKSVFGXXMFALGVVVKVPVPKQTAKTSFQTTSGKAKYNASIDSLVWKIRKFP 479
           R EI V  K   G  +   GV V   +PK     S   + G   ++     L W + K  
Sbjct: 290 RFEITVGPKQTMGKTIE--GVTVTSQMPKGVLNMSLTPSQGTHTFDPVTKMLSWDVGKIN 347

Query: 478 GQTEATMSAEVELISTMGEKKLANRPPIQMEFQVPMFTASGLRVRFLKVWEKSGYNTVEW 299
            Q   ++   + L   +G  K    P I ++F++     SGL+V  L ++ +  Y   + 
Sbjct: 348 PQKLPSLKGTMGL--QVGASKPDENPTINLQFKIQQLAISGLKVNRLDMYGEK-YKPFKG 404

Query: 298 VRYITRAGSYEIR 260
           ++Y+T+AG +++R
Sbjct: 405 IKYMTKAGKFQVR 417

>AP3M2_HUMAN (P53677) AP-3 complex subunit mu-2 (Adapter-related protein complex|
           3 mu-2 subunit) (Clathrin coat assembly protein AP47
           homolog 2) (Clathrin coat-associated protein AP47
           homolog 2) (Golgi adaptor AP-1 47 kDa protein homolog 2)
           (HA1 47 kDa su
          Length = 418

 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 34/133 (25%), Positives = 60/133 (45%)
 Frame = -3

Query: 658 RMEINVKVKSVFGXXMFALGVVVKVPVPKQTAKTSFQTTSGKAKYNASIDSLVWKIRKFP 479
           R EI V  K   G  +   GV V   +PK     S   + G   ++     L W + K  
Sbjct: 290 RFEITVGPKQTMGKTIE--GVTVTSQMPKGVLNMSLTPSQGTHTFDPVTKMLSWDVGKIN 347

Query: 478 GQTEATMSAEVELISTMGEKKLANRPPIQMEFQVPMFTASGLRVRFLKVWEKSGYNTVEW 299
            Q   ++   + L +  G  K    P I ++F++     SGL+V  L ++ +  Y   + 
Sbjct: 348 PQKLPSLKGTMSLQA--GASKPDENPTINLQFKIQQLAISGLKVNRLDMYGEK-YKPFKG 404

Query: 298 VRYITRAGSYEIR 260
           ++Y+T+AG +++R
Sbjct: 405 IKYMTKAGKFQVR 417

>AP4M1_RAT (Q2PWT8) AP-4 complex subunit mu-1 (Adapter-related protein complex|
           4 mu-1 subunit) (Mu subunit of AP-4) (AP-4 adapter
           complex mu subunit) (Mu-adaptin-related protein 2)
           (mu-ARP2) (mu4)
          Length = 453

 Score = 50.4 bits (119), Expect = 5e-06
 Identities = 32/143 (22%), Positives = 68/143 (47%), Gaps = 10/143 (6%)
 Frame = -3

Query: 658 RMEINVKVKSVFGXXMFALGVVVKVPVPKQTAKTSFQTTSGKAKYNASIDSLVWKIRKFP 479
           R+++ +K++        AL + + +P+P+     S + +S   K      +L W + +  
Sbjct: 310 RLQVYLKLRCDLPPKSQALNIHLHLPLPRGVVSLSQELSSPDQKAELGEGALHWDLPRVQ 369

Query: 478 GQTEATMSAEVELISTMGEKKLANRP--------PIQMEFQVPMFTASGLRVRFLKVWEK 323
           G ++ +   ++++    G       P        P  + F++P  T SGL+VRFL++   
Sbjct: 370 GGSQLSGLFQMDVPGLQGPPSRGPSPSAPPLGLGPASLSFELPRHTCSGLQVRFLRLSFS 429

Query: 322 S--GYNTVEWVRYITRAGSYEIR 260
           +    N  +WVR+++ + +Y IR
Sbjct: 430 ACGNANPHKWVRHLSHSNAYVIR 452

>AP4M1_MOUSE (Q9JKC7) AP-4 complex subunit mu-1 (Adapter-related protein complex|
           4 mu-1 subunit) (Mu subunit of AP-4) (AP-4 adapter
           complex mu subunit) (Mu-adaptin-related protein 2)
           (mu-ARP2) (mu4)
          Length = 449

 Score = 50.4 bits (119), Expect = 5e-06
 Identities = 32/139 (23%), Positives = 68/139 (48%), Gaps = 6/139 (4%)
 Frame = -3

Query: 658 RMEINVKVKSVFGXXMFALGVVVKVPVPKQTAKTSFQTTSGKAKYNASIDSLVWKIRKFP 479
           R+++ +K++        AL + + +P+P+     S + +S   K      +L W + +  
Sbjct: 310 RLQVYLKLRCDLPPKSQALNIHLHLPLPRGVISLSQELSSPDQKAELGEGALHWDLPRVQ 369

Query: 478 GQTEATMSAEVELISTMGEKKLANRP----PIQMEFQVPMFTASGLRVRFLKVWEKS--G 317
           G ++ +   ++++    G       P    P  + F++P  T SGL+VRFL++   +   
Sbjct: 370 GGSQLSGLFQMDVPGLQGLPNHGPSPLGLGPASLSFELPRHTCSGLQVRFLRLSFSACGN 429

Query: 316 YNTVEWVRYITRAGSYEIR 260
            N  +WVR+++ + +Y IR
Sbjct: 430 ANPHKWVRHLSHSNAYVIR 448

>AP1M_DISOM (P47795) AP-1 complex subunit mu (Clathrin coat assembly protein|
           AP47 homolog) (Clathrin coat-associated protein AP47
           homolog) (Golgi adaptor AP-1 47 kDa protein homolog)
           (HA1 47 kDa subunit homolog) (Clathrin assembly protein
           assembly protein
          Length = 418

 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 28/113 (24%), Positives = 54/113 (47%)
 Frame = -3

Query: 598 VVVKVPVPKQTAKTSFQTTSGKAKYNASIDSLVWKIRKFPGQTEATMSAEVELISTMGEK 419
           ++V + +PK     +     G   ++     L+W I K       T+   + L S  GE 
Sbjct: 308 ILVIIHMPKVVLNMTLTAAQGNFTFDPVTKVLIWDIGKIILPKLPTLKGLINLQS--GEA 365

Query: 418 KLANRPPIQMEFQVPMFTASGLRVRFLKVWEKSGYNTVEWVRYITRAGSYEIR 260
           K    P + ++F++     SGL+V  L ++ +  Y   + V+Y+T+AG +++R
Sbjct: 366 KPEENPTLNIQFRIQQLAVSGLKVNRLDMYGER-YKPFKGVKYVTKAGKFQVR 417

>AP4M1_HUMAN (O00189) AP-4 complex subunit mu-1 (Adapter-related protein complex|
           4 mu-1 subunit) (Mu subunit of AP-4) (AP-4 adapter
           complex mu subunit) (Mu-adaptin-related protein 2)
           (mu-ARP2) (mu4)
          Length = 453

 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 32/143 (22%), Positives = 69/143 (48%), Gaps = 10/143 (6%)
 Frame = -3

Query: 658 RMEINVKVKSVFGXXMFALGVVVKVPVPKQTAKTSFQTTSGKAKYNASIDSLVWKIRKFP 479
           R+++ +K++        AL V + +P+P+     S + +S + K   +  +L W + +  
Sbjct: 310 RLQVYLKLRCDLLSKSQALNVRLHLPLPRGVVSLSRELSSPEQKAELAEGALRWDLPRVQ 369

Query: 478 GQTEATMSAEVELISTMGEKKLA--------NRPPIQMEFQVPMFTASGLRVRFLKVWEK 323
           G ++ +   ++++    G                P  + F++P  T SGL+VRFL++  +
Sbjct: 370 GGSQLSGLFQMDVPGPPGPPSHGLSTSASPLGLGPASLSFELPRHTCSGLQVRFLRLAFR 429

Query: 322 --SGYNTVEWVRYITRAGSYEIR 260
                N  +WVR+++ + +Y IR
Sbjct: 430 PCGNANPHKWVRHLSHSDAYVIR 452

>APM2_YEAST (P38700) Adaptin medium chain homolog APM2|
          Length = 605

 Score = 41.6 bits (96), Expect = 0.002
 Identities = 43/188 (22%), Positives = 72/188 (38%), Gaps = 63/188 (33%)
 Frame = -3

Query: 658 RMEINVKVKSVFGXXMFALGVVVKVPVPKQ--------TAKTSFQTTSGKAKYNASIDSL 503
           +++I  K+++ F        + V++P+ K         + +  F+   GK  +N S D L
Sbjct: 408 KIQIVTKIQTNFKPTNSTSKLNVRIPLTKVFQEYKIDLSKQIRFKANIGKVVFNLSDDFL 467

Query: 502 VWKIRKFPGQTE-------------------ATMSAEVELIST------MGEKKLANRPP 398
           +W+I+   G  E                   A+M AE  L +         E K +  PP
Sbjct: 468 LWEIQTMKGHREHSTNKSSQYNSDEDDPNTCASMVAEFPLFNQEEYDRLQEEMKTSMNPP 527

Query: 397 -----------------------------IQMEFQVPMFTASGLRVRFLKVWE-KSGYNT 308
                                        + ++F++P  T SGL+V +LKV E +  Y +
Sbjct: 528 PLRTGPRLEELYRQVHDQQTSHVTPRDKLVNIDFEIPYCTCSGLKVEYLKVEEPQLQYQS 587

Query: 307 VEWVRYIT 284
             WVRY T
Sbjct: 588 FPWVRYKT 595

>STON2_HUMAN (Q8WXE9) Stonin-2 (Stoned B)|
          Length = 905

 Score = 39.7 bits (91), Expect = 0.008
 Identities = 28/93 (30%), Positives = 47/93 (50%), Gaps = 6/93 (6%)
 Frame = -3

Query: 550  QTTSGKAKYNASIDSLVWKIRKFPGQTEAT-----MSAEVELISTMG-EKKLANRPPIQM 389
            + T G AKY  + +S+VW+I + P +  A+         +EL S      + AN   + +
Sbjct: 776  RVTLGTAKYEHAFNSIVWRINRLPDKNSASGHPHCFFCHLELGSDREVPSRFANH--VNV 833

Query: 388  EFQVPMFTASGLRVRFLKVWEKSGYNTVEWVRY 290
            EF +P  +AS   VR + V +K+  +  +WV Y
Sbjct: 834  EFSMPTTSASKASVRSISVEDKT--DVRKWVNY 864

>STON2_MOUSE (Q8BZ60) Stonin-2 (Stoned B)|
          Length = 895

 Score = 37.7 bits (86), Expect = 0.031
 Identities = 28/93 (30%), Positives = 46/93 (49%), Gaps = 6/93 (6%)
 Frame = -3

Query: 550  QTTSGKAKYNASIDSLVWKIRKFPGQTEAT-----MSAEVELISTMG-EKKLANRPPIQM 389
            + T G AKY  + +S+VW+I + P +  A+         +EL S      + AN   + +
Sbjct: 773  RVTLGTAKYEHAFNSIVWRINRLPDKNSASGHPHCFFCHLELGSDREVPSRFANY--VNV 830

Query: 388  EFQVPMFTASGLRVRFLKVWEKSGYNTVEWVRY 290
            EF +P  +AS   VR + V +K   +  +WV Y
Sbjct: 831  EFSMPTTSASKAAVRSVSVEDKP--DVRKWVNY 861

>STNB_CAEEL (P90761) Putative stoned B-like protein (Unc-41)|
          Length = 1657

 Score = 37.4 bits (85), Expect = 0.040
 Identities = 28/94 (29%), Positives = 45/94 (47%), Gaps = 8/94 (8%)
 Frame = -3

Query: 538  GKAKYNASIDSLVWKIRKFPGQTEATMSA-------EVELISTMGEKKLANRPPIQMEFQ 380
            G+AKY     SLVW+I + P +  A   +       E+     M E+ L   P   ++F 
Sbjct: 1472 GEAKYEHVYRSLVWRIPRLPEKHHAAYKSHLLKCRFELSSFDLMPEEFL---PRCDVDFT 1528

Query: 379  VPMFTASGLRVRFLKVWEKSGYNTVE-WVRYITR 281
            +P+ T S   VR + V +    + VE +VRY+ +
Sbjct: 1529 MPLATVSNTVVRSVSVEQHEDSDRVEKFVRYVAK 1562

>STNB_DROME (Q24212) Protein stoned-B (StonedB) (Stn-B)|
          Length = 1262

 Score = 33.1 bits (74), Expect = 0.76
 Identities = 27/98 (27%), Positives = 45/98 (45%), Gaps = 8/98 (8%)
 Frame = -3

Query: 550  QTTSGKAKYNASIDSLVWKIRKFPGQTEATMSAEVELISTMG-------EKKLANRPPIQ 392
            + TSG+AKY     ++VW+  + P + +   +   +L+  M          +LA  P   
Sbjct: 1117 EVTSGQAKYEHHHRAIVWRCPRLPKEGQGAYTTH-QLVCRMALTSYDQIPSELA--PYAF 1173

Query: 391  MEFQVPMFTASGLRVRFLKVWEKSGYNTVE-WVRYITR 281
            +EF +P    S   VR + V +  G    E +VRY+ R
Sbjct: 1174 VEFTMPATQVSHTTVRSVSVQDSDGDEPPEKYVRYLAR 1211

>STON1_HUMAN (Q9Y6Q2) Stonin-1 (Stoned B-like factor)|
          Length = 735

 Score = 33.1 bits (74), Expect = 0.76
 Identities = 26/78 (33%), Positives = 38/78 (48%), Gaps = 5/78 (6%)
 Frame = -3

Query: 550 QTTSGKAKYNASIDSLVWKIRKFPGQTEA-----TMSAEVELISTMGEKKLANRPPIQME 386
           Q T G AKY ++  ++VWKI + P +  +      +S ++EL S   E      P   ++
Sbjct: 616 QVTVGSAKYESAYQAVVWKIDRLPDKNSSLDHPHCLSYKLELGSDQ-EIPSDWYPFATVQ 674

Query: 385 FQVPMFTASGLRVRFLKV 332
           F VP   AS   VR L V
Sbjct: 675 FSVPDTCASRTEVRSLGV 692

>GHC2_HUMAN (Q9H1K4) Mitochondrial glutamate carrier 2 (GC-2) (Glutamate/H(+)|
           symporter 2) (Solute carrier family 25 member 18)
          Length = 315

 Score = 30.8 bits (68), Expect = 3.8
 Identities = 24/83 (28%), Positives = 34/83 (40%)
 Frame = -3

Query: 661 TRMEINVKVKSVFGXXMFALGVVVKVPVPKQTAKTSFQTTSGKAKYNASIDSLVWKIRKF 482
           T  ++++  K + G     +GV    P+    AKT  Q   GKA Y   ID L+ K  + 
Sbjct: 2   THQDLSITAKLINGGVAGLVGVTCVFPI--DLAKTRLQNQHGKAMYKGMIDCLM-KTARA 58

Query: 481 PGQTEATMSAEVELISTMGEKKL 413
            G       A V L     EK +
Sbjct: 59  EGFFGMYRGAAVNLTLVTPEKAI 81

>GALT6_CAEEL (O61394) Probable N-acetylgalactosaminyltransferase 6 (EC 2.4.1.-)|
           (Protein-UDP acetylgalactosaminyltransferase 6)
           (UDP-GalNAc:polypeptide
           N-acetylgalactosaminyltransferase 6) (pp-GaNTase 6)
          Length = 618

 Score = 30.4 bits (67), Expect = 4.9
 Identities = 23/66 (34%), Positives = 30/66 (45%), Gaps = 7/66 (10%)
 Frame = +2

Query: 56  GGRIHI-PCQHENKEHRKTACSDLPSAGVQTHRELGHNLRAF*SIMMRT------KRAPQ 214
           GGR+ I PC H     RK++  D P  G  + + L  NL     + M        K APQ
Sbjct: 373 GGRVEILPCSHVGHVFRKSSPHDFP--GKSSGKVLNTNLLRVAEVWMDDWKHYFYKIAPQ 430

Query: 215 IHEIRS 232
            H +RS
Sbjct: 431 AHRMRS 436

>AMPL3_ARATH (Q944P7) Leucine aminopeptidase 3, chloroplast precursor (EC|
           3.4.11.1) (LAP 3) (Leucyl aminopeptidase 3) (Proline
           aminopeptidase 3) (EC 3.4.11.5) (Prolyl aminopeptidase
           3)
          Length = 583

 Score = 29.6 bits (65), Expect = 8.4
 Identities = 16/64 (25%), Positives = 31/64 (48%), Gaps = 4/64 (6%)
 Frame = -1

Query: 399 RFRWNSRFRCSLLLVYVFGSSRCGRRVATTPLSGFATSQGLDHMKSGVSDQE----KWRG 232
           RF++ SR R +  +  ++ SSR      +    G   +  +DH K   S +E    +W+G
Sbjct: 34  RFQFPSRLRLAFAVTPLYSSSRAMAHTISHATLGLTQANSVDHPKISFSGKEIDVTEWKG 93

Query: 231 LLIS 220
            +++
Sbjct: 94  DILA 97


  Database: uniprot_sprot.fasta
    Posted date:  May 25, 2006  5:36 PM
  Number of letters in database: 80,573,946
  Number of sequences in database:  219,361
  
Lambda     K      H
   0.318    0.135    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 99,439,445
Number of Sequences: 219361
Number of extensions: 2180078
Number of successful extensions: 4635
Number of sequences better than 10.0: 33
Number of HSP's better than 10.0 without gapping: 4478
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4600
length of database: 80,573,946
effective HSP length: 108
effective length of database: 56,882,958
effective search space used: 6370891296
frameshift window, decay const: 50,  0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)