Clone Name	FLbaf160e10
Clone Library Name	barley_pub

---

No.	Definition	Score (bits)	E Value
1	P22200:KPYC_SOLTU Pyruvate kinase, cytosolic isozyme - Solanum t...	337	2e-91
2	Q42806:KPYC_SOYBN Pyruvate kinase, cytosolic isozyme - Glycine m...	335	3e-91
3	O65595:KPYC_ARATH Probable pyruvate kinase, cytosolic isozyme - ...	324	8e-88
4	Q42954:KPYC_TOBAC Pyruvate kinase, cytosolic isozyme - Nicotiana...	323	2e-87
5	O44006:KPYK_EIMTE Pyruvate kinase - Eimeria tenella	265	4e-70
6	P80885:KPYK_BACSU Pyruvate kinase - Bacillus subtilis	261	6e-69
7	P51181:KPYK_BACLI Pyruvate kinase - Bacillus licheniformis	259	4e-68
8	P51182:KPYK_BACPY Pyruvate kinase - Bacillus psychrophilus (Spor...	256	3e-67
9	P77983:KPYK1_SALTY Pyruvate kinase I - Salmonella typhimurium	253	2e-66
10	Q8Z6K2:KPYK1_SALTI Pyruvate kinase I - Salmonella typhi	253	2e-66
11	Q02499:KPYK_BACST Pyruvate kinase - Bacillus stearothermophilus ...	253	3e-66
12	P11980:KPYM_RAT Pyruvate kinase isozymes M1/M2 - Rattus norvegic...	252	4e-66
13	P0AD61:KPYK1_ECOLI Pyruvate kinase I - Escherichia coli	252	4e-66
14	P0AD62:KPYK1_ECO57 Pyruvate kinase I - Escherichia coli O157:H7	252	4e-66
15	P11979:KPYM_FELCA Pyruvate kinase isozyme M1 - Felis silvestris ...	252	5e-66
16	Q49YC7:KPYK_STAS1 Pyruvate kinase - Staphylococcus saprophyticus...	251	9e-66
17	Q29536:KPYR_CANFA Pyruvate kinase isozyme R - Canis familiaris (...	249	3e-65
18	Q27788:KPYK_TRYBO Pyruvate kinase - Trypanoplasma borreli	249	3e-65
19	Q27686:KPYK_LEIME Pyruvate kinase - Leishmania mexicana	248	6e-65
20	P11974:KPYM_RABIT Pyruvate kinase isozymes M1/M2 - Oryctolagus c...	248	1e-64
21	P14618:KPYM_HUMAN Pyruvate kinase isozymes M1/M2 - Homo sapiens ...	248	1e-64
22	Q5NVN0:KPYM_PONPY Pyruvate kinase isozyme M1 - Pongo pygmaeus (O...	247	1e-64
23	P52480:KPYM_MOUSE Pyruvate kinase isozymes M1/M2 - Mus musculus ...	247	2e-64
24	O62619:KPYK_DROME Pyruvate kinase - Drosophila melanogaster (Fru...	247	2e-64
25	Q12669:KPYK_ASPNG Pyruvate kinase - Aspergillus niger	247	2e-64
26	Q6GG09:KPYK_STAAR Pyruvate kinase - Staphylococcus aureus (strai...	246	3e-64
27	O08309:KPYK_CLOAB Pyruvate kinase - Clostridium acetobutylicum	245	6e-64
28	Q7A0N4:KPYK_STAAW Pyruvate kinase - Staphylococcus aureus (strai...	244	8e-64
29	Q6G8M9:KPYK_STAAS Pyruvate kinase - Staphylococcus aureus (strai...	244	8e-64
30	Q7A559:KPYK_STAAN Pyruvate kinase - Staphylococcus aureus (strai...	244	8e-64
31	Q99TG5:KPYK_STAAM Pyruvate kinase - Staphylococcus aureus (strai...	244	8e-64
32	Q5HF76:KPYK_STAAC Pyruvate kinase - Staphylococcus aureus (strai...	244	8e-64
33	Q2YTE3:KPYK_STAAB Pyruvate kinase - Staphylococcus aureus (strai...	244	8e-64
34	Q2FXM9:KPYK_STAA8 Pyruvate kinase - Staphylococcus aureus (strai...	244	8e-64
35	Q2FG40:KPYK_STAA3 Pyruvate kinase - Staphylococcus aureus (strai...	244	8e-64
36	P22360:KPYK_EMENI Pyruvate kinase - Emericella nidulans (Aspergi...	244	1e-63
37	P30613:KPYR_HUMAN Pyruvate kinase isozymes R/L - Homo sapiens (H...	243	2e-63
38	P00548:KPYK_CHICK Pyruvate kinase muscle isozyme - Gallus gallus...	243	2e-63
39	P30616:KPYK2_TRYBB Pyruvate kinase 2 - Trypanosoma brucei brucei	240	2e-62
40	Q8CS69:KPYK_STAES Pyruvate kinase - Staphylococcus epidermidis (...	239	3e-62
41	Q5HNK7:KPYK_STAEQ Pyruvate kinase - Staphylococcus epidermidis (...	239	3e-62
42	P30615:KPYK1_TRYBB Pyruvate kinase 1 - Trypanosoma brucei brucei	239	3e-62
43	Q92122:KPYK_XENLA Pyruvate kinase muscle isozyme - Xenopus laevi...	238	1e-61
44	P12928:KPYR_RAT Pyruvate kinase isozymes R/L - Rattus norvegicus...	237	2e-61
45	Q7RVA8:KPYK_NEUCR Pyruvate kinase - Neurospora crassa	234	8e-61
46	P31865:KPYK_TRIRE Pyruvate kinase - Trichoderma reesei (Hypocrea...	234	1e-60
47	P53657:KPYR_MOUSE Pyruvate kinase isozymes R/L - Mus musculus (M...	234	1e-60
48	Q4L739:KPYK_STAHJ Pyruvate kinase - Staphylococcus haemolyticus ...	233	2e-60
49	O94122:KPYK_AGABI Pyruvate kinase - Agaricus bisporus (Common mu...	233	2e-60
50	Q6BS75:KPYK_DEBHA Pyruvate kinase - Debaryomyces hansenii (Yeast...	233	3e-60
51	Q46289:KPYK_CLOPE Pyruvate kinase - Clostridium perfringens	232	5e-60
52	P30614:KPYK_YARLI Pyruvate kinase - Yarrowia lipolytica (Candida...	231	7e-60
53	Q759A9:KPYK_ASHGO Pyruvate kinase - Ashbya gossypii (Yeast) (Ere...	229	5e-59
54	Q10208:KPYK_SCHPO Pyruvate kinase - Schizosaccharomyces pombe (F...	226	2e-58
55	Q875S4:KPYK_SACKL Pyruvate kinase - Saccharomyces kluyveri (Yeas...	226	3e-58
56	P34038:KPYK_LACDE Pyruvate kinase - Lactobacillus delbrueckii su...	225	5e-58
57	Q6FV12:KPYK2_CANGA Pyruvate kinase 2 - Candida glabrata (Yeast) ...	223	3e-57
58	Q875M9:KPYK_KLULA Pyruvate kinase - Kluyveromyces lactis (Yeast)...	219	3e-56
59	P52489:KPYK2_YEAST Pyruvate kinase 2 - Saccharomyces cerevisiae ...	218	8e-56
60	Q6FIS9:KPYK1_CANGA Pyruvate kinase 1 - Candida glabrata (Yeast) ...	214	9e-55
61	P00549:KPYK1_YEAST Pyruvate kinase 1 - Saccharomyces cerevisiae ...	214	2e-54
62	Q875Z9:KPYK_SACCA Pyruvate kinase - Saccharomyces castellii (Yeast)	211	8e-54
63	Q55863:KPYK1_SYNY3 Pyruvate kinase 1 - Synechocystis sp. (strain...	209	4e-53
64	Q9WY51:KPYK_THEMA Pyruvate kinase - Thermotoga maritima	188	9e-47
65	P73534:KPYK2_SYNY3 Pyruvate kinase 2 - Synechocystis sp. (strain...	187	1e-46
66	P94939:KPYK_MYCIT Pyruvate kinase - Mycobacterium intracellulare	183	2e-45
67	O06134:KPYK_MYCTU Pyruvate kinase - Mycobacterium tuberculosis	182	5e-45
68	Q9PK61:KPYK_CHLMU Pyruvate kinase - Chlamydia muridarum	180	2e-44
69	Q46078:KPYK_CORGL Pyruvate kinase - Corynebacterium glutamicum (...	176	3e-43
70	P94685:KPYK_CHLTR Pyruvate kinase - Chlamydia trachomatis	176	4e-43
71	Q44473:KPYK2_AGRVI Pyruvate kinase - Agrobacterium vitis (Rhizob...	175	8e-43
72	Q8FP04:KPYK_COREF Pyruvate kinase - Corynebacterium efficiens	174	1e-42
73	Q40546:KPYG_TOBAC Pyruvate kinase isozyme G, chloroplast precurs...	173	3e-42
74	Q9Z984:KPYK_CHLPN Pyruvate kinase - Chlamydia pneumoniae (Chlamy...	172	5e-42
75	O51323:KPYK_BORBU Pyruvate kinase - Borrelia burgdorferi (Lyme d...	167	1e-40
76	P70789:KPYK1_AGRVI Pyruvate kinase - Agrobacterium vitis (Rhizob...	165	6e-40
77	Q07637:KPYK_LACLA Pyruvate kinase - Lactococcus lactis subsp. la...	164	2e-39
78	P21599:KPYK2_ECOLI Pyruvate kinase II - Escherichia coli	160	3e-38
79	Q8ZNW0:KPYK2_SALTY Pyruvate kinase II - Salmonella typhimurium	159	4e-38
80	P78031:KPYK_MYCPN Pyruvate kinase - Mycoplasma pneumoniae	155	6e-37
81	P43924:KPYK_HAEIN Pyruvate kinase - Haemophilus influenzae	155	8e-37
82	P32044:KPYK_THEAC Pyruvate kinase - Thermoplasma acidophilum	152	5e-36
83	P47458:KPYK_MYCGE Pyruvate kinase - Mycoplasma genitalium	152	5e-36
84	O05118:KPYK_METEX Pyruvate kinase - Methylobacterium extorquens ...	151	1e-35
85	Q43117:KPYA_RICCO Pyruvate kinase isozyme A, chloroplast precurs...	150	2e-35
86	Q40545:KPYA_TOBAC Pyruvate kinase isozyme A, chloroplast precurs...	145	5e-34
87	P57404:KPYK_BUCAI Pyruvate kinase - Buchnera aphidicola subsp. A...	144	2e-33
88	Q57572:KPYK_METJA Pyruvate kinase - Methanococcus jannaschii	143	3e-33
89	Q89AI8:KPYK_BUCBP Pyruvate kinase - Buchnera aphidicola subsp. B...	139	6e-32
90	P55964:KPYG_RICCO Pyruvate kinase isozyme G, chloroplast - Ricin...	136	3e-31
91	Q9YEU2:KPYK_AERPE Pyruvate kinase - Aeropyrum pernix	132	4e-30
92	Q8K9M3:KPYK_BUCAP Pyruvate kinase - Buchnera aphidicola subsp. S...	127	2e-28
93	O30853:KPYK1_PHOLE Pyruvate kinase I - Photobacterium leiognathi	124	1e-27
94	Q8ZYE0:KPYK_PYRAE Pyruvate kinase - Pyrobaculum aerophilum	108	7e-23
95	Q56301:KPYK_THELI Pyruvate kinase - Thermococcus litoralis	94	2e-18
96	Q04668:KPYK_LEIBR Pyruvate kinase - Leishmania braziliensis	63	4e-09
97	P19680:KPYK_SPICI Pyruvate kinase - Spiroplasma citri	50	3e-05
98	Q7SAX8:FIP1_NEUCR Pre-mRNA polyadenylation factor fip-1 - Neuros...	38	0.20
99	A0M574:RS4_GRAFK 30S ribosomal protein S4 - Gramella forsetii (s...	35	1.7
100	P39737:YVYC_BACSU Uncharacterized protein yvyC - Bacillus subtilis	34	2.2
101	Q9NU02:ANKR5_HUMAN Ankyrin repeat domain-containing protein 5 - ...	33	3.7
102	Q84GK0:EATA_ECOLI Serine protease eatA precursor - Escherichia coli	33	4.8
103	P50748:KNTC1_HUMAN Kinetochore-associated protein 1 - Homo sapie...	33	6.3
104	P49863:GRAK_HUMAN Granzyme K precursor - Homo sapiens (Human)	33	6.3
105	P97043:TRME_LEPIN Probable tRNA modification GTPase trmE - Lepto...	32	8.2
106	Q72VY6:TRME_LEPIC tRNA modification GTPase trmE - Leptospira int...	32	8.2
107	P25009:PUC1_SCHPO Cyclin puc1 - Schizosaccharomyces pombe (Fissi...	32	8.2
108	Q8NUT2:LDHD_STAAW D-lactate dehydrogenase - Staphylococcus aureu...	32	8.2
109	Q6G6F1:LDHD_STAAS D-lactate dehydrogenase - Staphylococcus aureu...	32	8.2

---

>P22200:KPYC_SOLTU Pyruvate kinase, cytosolic isozyme - Solanum tuberosum (Potato)|
          Length = 510
 Score =  337 bits (863), Expect = 2e-91
 Identities = 199/494 (40%), Positives = 293/494 (59%), Gaps = 2/494 (0%)
 Frame = +3

Query: 294  TKIVGTLGPNSHSVEVIEECLTAGMSVARFDFSWKDATYHQETLDNLRKAAQNVKKLCPI 473
            TKIV TLGP+S +V ++E+ L AGM+VARF+FS     YHQETLDNL+ A QN + LC +
Sbjct: 22   TKIVCTLGPSSRTVPMLEKLLRAGMNVARFNFSHGTHEYHQETLDNLKIAMQNTQILCAV 81

Query: 474  MLDTVGPEIQVHNPTGG-AIELIGGNHVTITPDLSKAPSADILPIKFGDLAKVVKKGDTL 650
            MLDT GPEI+    T G  I+L  G  +T++ D +   + +++ + +  L   +K G+T 
Sbjct: 82   MLDTKGPEIRTGFLTDGKPIQLKEGQEITVSTDYTIKGNEEMISMSYKKLVMDLKPGNT- 140

Query: 651  FIGQYLFTGSETTSLWLEVMETSGEEVICFVKNTATLSGPIFTLHVSQVHISMPTLSEYD 830
                 +     T +L +   +     V C  +NTATL G    +++  V + +PTL+E D
Sbjct: 141  -----ILCADGTITLTVLSCDPPSGTVRCRCENTATL-GERKNVNLPGVVVDLPTLTEKD 194

Query: 831  KQVISTWGLDNSVDIISLSHTRSSEDVRELRAFLQSHNLQDTQIYAKIENAEGLEHFDEI 1010
            K+ I  WG+ N++D+I+LS  R   D+  +R  L  H  +  Q+ +K+EN EG+ +FDEI
Sbjct: 195  KEDILEWGVPNNIDMIALSFVRKGSDLVNVRKVLGPH-AKRIQLMSKVENQEGVINFDEI 253

Query: 1011 LQEADGIIISRGDLGIDLPPERVFMSQKTGIHKCNMAGKPVI-ITRVVDSMIDNLRPTRA 1187
            L+E D  +++RGDLG+++P E++F++QK  I+KCN+AGK V+  T++++SMI +  PTRA
Sbjct: 254  LRETDSFMVARGDLGMEIPVEKIFLAQKMMIYKCNLAGKAVVTATQMLESMIKSPAPTRA 313

Query: 1188 EATDVANAVLDGTDGILLGAETLRGQYPVDAVSTVGRICAEAETVYNQSLHFKKVVRHVG 1367
            EATDVANAVLDGTD ++L  E+  G YP  AV  + RIC EAE+  +    FK+++R   
Sbjct: 314  EATDVANAVLDGTDCVMLSGESAAGAYPELAVKIMSRICIEAESSLDNEAIFKEMIRCTP 373

Query: 1368 EPMAHEEXXXXXXXXXXXXXXXXXIVVFTFSGRAARLVAKYRPPMPVLAVVFPREGSDPS 1547
             PM+  E                 IVV T  G  A+LVAKYRP +P+L+VV P   +D  
Sbjct: 374  LPMSPLESLASSAVRTANKARAKLIVVLTRGGSTAKLVAKYRPAVPILSVVVPVLTTDSF 433

Query: 1548 KWRSYGTTQARQCFSVRGVYPLMGSTDEAETGGLTKEAYGIKLALNYGRSVGIIKPYDRV 1727
             W     T AR     RG+ PL+G      T   + E   ++ AL    + G+ KP D V
Sbjct: 434  DWSISDETPARHSLVYRGLIPLLGEGSAKATDSESTEVI-LEAALKSAVTRGLCKPGDAV 492

Query: 1728 IIFEKIGDSSVVKI 1769
            +   +IG +SV+KI
Sbjct: 493  VALHRIGSASVIKI 506

---

>Q42806:KPYC_SOYBN Pyruvate kinase, cytosolic isozyme - Glycine max (Soybean)|
          Length = 511

 Score =  335 bits (860), Expect = 3e-91
 Identities = 200/494 (40%), Positives = 286/494 (57%), Gaps = 2/494 (0%)
 Frame = +3

Query: 294  TKIVGTLGPNSHSVEVIEECLTAGMSVARFDFSWKDATYHQETLDNLRKAAQNVKKLCPI 473
            TKIV TLGP S SVE+ E+ L AGM+VARF+FS     YHQETL+NL+ A  N   LC +
Sbjct: 23   TKIVCTLGPASRSVEMTEKLLRAGMNVARFNFSHGTHDYHQETLNNLKTAMHNTGILCAV 82

Query: 474  MLDTVGPEIQV-HNPTGGAIELIGGNHVTITPDLSKAPSADILPIKFGDLAKVVKKGDTL 650
            MLDT GPEI+      G  I+L  G  VTIT D       +++ + +  L   +K G+T 
Sbjct: 83   MLDTKGPEIRTGFLKDGKPIQLKEGQEVTITTDYDIKGDPEMISMSYKKLPVHLKPGNT- 141

Query: 651  FIGQYLFTGSETTSLWLEVMETSGEEVICFVKNTATLSGPIFTLHVSQVHISMPTLSEYD 830
                 +     T +L +   +     V C  +NTATL G    +++  V + +PTL+E D
Sbjct: 142  -----ILCSDGTITLTVLSCDPDAGTVRCRCENTATL-GERKNVNLPGVVVDLPTLTEKD 195

Query: 831  KQVISTWGLDNSVDIISLSHTRSSEDVRELRAFLQSHNLQDTQIYAKIENAEGLEHFDEI 1010
            K+ I  WG+ N +D+I+LS  R   D+  +R  L  H  ++ Q+ +K+EN EG+ +FDEI
Sbjct: 196  KEDILGWGVPNKIDMIALSFVRKGSDLVNVRKVLGPH-AKNIQLMSKVENQEGVLNFDEI 254

Query: 1011 LQEADGIIISRGDLGIDLPPERVFMSQKTGIHKCNMAGKPVI-ITRVVDSMIDNLRPTRA 1187
            L+E D  +++RGDLG+++P E++F++QK  I+KCN+ GKPV+  T++++SMI + RPTRA
Sbjct: 255  LRETDAFMVARGDLGMEIPVEKIFLAQKMMIYKCNLVGKPVVTATQMLESMIKSPRPTRA 314

Query: 1188 EATDVANAVLDGTDGILLGAETLRGQYPVDAVSTVGRICAEAETVYNQSLHFKKVVRHVG 1367
            EATDVANAVLDGTD ++L  E+  G YP  AV  + RIC EAE+  +    FK+++R   
Sbjct: 315  EATDVANAVLDGTDCVMLSGESAAGAYPELAVKIMARICIEAESSLDYGAIFKEMIRSTP 374

Query: 1368 EPMAHEEXXXXXXXXXXXXXXXXXIVVFTFSGRAARLVAKYRPPMPVLAVVFPREGSDPS 1547
             PM+  E                 IVV T  G  A+LVAKYRP +P+L+VV P   +D  
Sbjct: 375  LPMSPLESLASSAVRTANKAKAKLIVVLTRGGSTAKLVAKYRPAVPILSVVVPVLSTDSF 434

Query: 1548 KWRSYGTTQARQCFSVRGVYPLMGSTDEAETGGLTKEAYGIKLALNYGRSVGIIKPYDRV 1727
             W     T AR     RG+ P++G      T   + E   ++ AL       + KP D V
Sbjct: 435  DWTCSDETPARHSLIYRGLIPILGEGSAKATDAESTEVI-LEAALKSATERALCKPGDAV 493

Query: 1728 IIFEKIGDSSVVKI 1769
            +   +IG +SV+KI
Sbjct: 494  VALHRIGAASVIKI 507

---

>O65595:KPYC_ARATH Probable pyruvate kinase, cytosolic isozyme - Arabidopsis thaliana|
            (Mouse-ear cress)
          Length = 497

 Score =  324 bits (831), Expect = 8e-88
 Identities = 197/496 (39%), Positives = 281/496 (56%), Gaps = 3/496 (0%)
 Frame = +3

Query: 294  TKIVGTLGPNSHSVEVIEECLTAGMSVARFDFSWKDATYHQETLDNLRKAAQNVKKLCPI 473
            TKIV TLGP S SV ++E+ L AGMSVARF+FS     YHQETLDNLR+A  N   LC +
Sbjct: 9    TKIVCTLGPASRSVPMVEKLLMAGMSVARFNFSHGSYEYHQETLDNLRQAMLNTGMLCAV 68

Query: 474  MLDTVGPEIQV-HNPTGGAIELIGGNHVTITPDLSKAPSADILPIKFGDLAKVVKKGDTL 650
            MLDT GPEI+      G  I+L  G  +TI+ D         + + +  LA+ V      
Sbjct: 69   MLDTKGPEIRTGFLKDGKPIQLKQGQEITISTDYDLKGDEKTICMSYKKLAQDVNP---- 124

Query: 651  FIGQYLFTGSETTSLWLEVMETSGEEVICFVKNTATLSGPIFTLHVSQVHISMPTLSEYD 830
              G  +     T SL +   +     V C  +NT+ L G    +++  V + +PTL+E D
Sbjct: 125  --GMVILCADGTISLKVLSCDKEKGTVRCRCENTSML-GERKNVNLPGVVVDLPTLTEKD 181

Query: 831  KQVISTWGLDNSVDIISLSHTRSSEDVRELRAFLQSHNLQDTQIYAKIENAEGLEHFDEI 1010
            KQ I  WG+ N +D+I+LS  R   D+ ++R  L  H  +   + +K+EN EG+ +FD+I
Sbjct: 182  KQDILEWGVPNQIDMIALSFVRKGSDLVQVRKLLGKH-AKTILLMSKVENQEGVANFDDI 240

Query: 1011 LQEADGIIISRGDLGIDLPPERVFMSQKTGIHKCNMAGKPVI-ITRVVDSMIDNLRPTRA 1187
            L  +D  +I+RGDLG+++P E++F++QK  I+KCN  GKPV+  T++++SMI + RPTRA
Sbjct: 241  LINSDAFMIARGDLGMEIPIEKIFLAQKVMIYKCNFMGKPVVTATQMLESMIKSPRPTRA 300

Query: 1188 EATDVANAVLDGTDGILLGAETLRGQYPVDAVSTVGRICAEAETVYNQSLHFKKVVRHVG 1367
            EATDVANAVLDGTD ++L  ET  G YP  AV T+ +IC EAE+  +    FK+++ H  
Sbjct: 301  EATDVANAVLDGTDCVMLSGETAAGAYPELAVRTMAKICVEAESTLDYGDIFKRIMLHAA 360

Query: 1368 EPMAHEEXXXXXXXXXXXXXXXXXIVVFTFSGRAARLVAKYRPPMPVLAVVFPREGSDPS 1547
             PM+  E                 ++V T  G  ARLVAKYRP +P+L+VV P   SD  
Sbjct: 361  VPMSPMESLASSAVRTATSSRATLMMVLTRGGSTARLVAKYRPGIPILSVVVPEITSDSF 420

Query: 1548 KWRSYGTTQARQCFSVRGVYP-LMGSTDEAETGGLTKEAYGIKLALNYGRSVGIIKPYDR 1724
             W       AR     RG+ P L   +  A     T+E   ++ A  YG+   + K  D 
Sbjct: 421  DWACSNEAPARHSLIYRGLVPVLYAGSARASIDESTEET--LEFASEYGKKKQLCKTGDS 478

Query: 1725 VIIFEKIGDSSVVKII 1772
            V+   + G++ V+KI+
Sbjct: 479  VVALFRTGNAIVIKIL 494

---

>Q42954:KPYC_TOBAC Pyruvate kinase, cytosolic isozyme - Nicotiana tabacum (Common|
            tobacco)
          Length = 508

 Score =  323 bits (827), Expect = 2e-87
 Identities = 195/500 (39%), Positives = 291/500 (58%), Gaps = 7/500 (1%)
 Frame = +3

Query: 294  TKIVGTLGPNSHSVEVIEECLTAGMSVARFDFSWKDATYHQETLDNLRKAAQNVKKLCPI 473
            TKIV TLGP S SV +IE+ L AGM+VARF+FS     YHQET+DNLR+A ++   LC +
Sbjct: 20   TKIVCTLGPASRSVPMIEKLLRAGMNVARFNFSHGSHDYHQETIDNLRQAMESTGILCAV 79

Query: 474  MLDTVGPEIQV-HNPTGGAIELIGGNHVTITPDLSKAPSADILPIKFGDLAKVVKKGDTL 650
            MLDT GPEI+         ++L  G  +TI+ D S      ++ + +  LA+ VK    +
Sbjct: 80   MLDTKGPEIRTGFLKDAKPVQLKQGQEITISTDYSIKGDESMICMSYKKLAEDVKPQSVI 139

Query: 651  FI--GQYLFTGSETTSLWLEVMETSGEEVI--CFVKNTATLSGPIFTLHVSQVHISMPTL 818
                GQ  FT          V+    E  +  C  +NTA L G    +++  V + +PTL
Sbjct: 140  LCADGQITFT----------VLSCDKENGLDRCRCENTAVL-GERKNVNLPGVIVDLPTL 188

Query: 819  SEYDKQVISTWGLDNSVDIISLSHTRSSEDVRELRAFLQSHNLQDTQIYAKIENAEGLEH 998
            ++ DK  I  WG+ N +D+I+LS  R   D+ E+R  L  H  ++  + +K+EN EG+ +
Sbjct: 189  TDKDKDDILNWGVPNHIDMIALSFVRKGSDLVEVRKLLGEH-AKNILLMSKVENQEGVAN 247

Query: 999  FDEILQEADGIIISRGDLGIDLPPERVFMSQKTGIHKCNMAGKPVI-ITRVVDSMIDNLR 1175
            FD+IL  +D  +++RGDLG+++P E++F++QK  I+KCN+ GKPV+  T++++SMI + R
Sbjct: 248  FDDILLNSDAFMVARGDLGMEIPIEKIFLAQKVMIYKCNIQGKPVVTATQMLESMIKSPR 307

Query: 1176 PTRAEATDVANAVLDGTDGILLGAETLRGQYPVDAVSTVGRICAEAETVYNQSLHFKKVV 1355
            PTRAEATDVANAVLDGTD ++L  ET  G YP  AV T+ +IC EAE+  +    FK+++
Sbjct: 308  PTRAEATDVANAVLDGTDCVMLSGETAAGAYPDLAVGTMAKICIEAESTIDYPDVFKRIM 367

Query: 1356 RHVGEPMAHEEXXXXXXXXXXXXXXXXXIVVFTFSGRAARLVAKYRPPMPVLAVVFPREG 1535
             +   PM+  E                 I+V T  G  A+LVAKYRP MP+L+VV P   
Sbjct: 368  SNAPVPMSPLESLASSAVRTANSAKAALILVLTRGGSTAKLVAKYRPGMPILSVVVPEIK 427

Query: 1536 SDPSKWRSYGTTQARQCFSVRGVYPLM-GSTDEAETGGLTKEAYGIKLALNYGRSVGIIK 1712
            +D   W     + AR     RG+ P++   +  A     T+EA  +  AL + ++ G+ K
Sbjct: 428  TDSFDWTCSDESPARHSLIFRGLVPVLHAGSARASHEESTEEA--LDFALQHAKTKGLCK 485

Query: 1713 PYDRVIIFEKIGDSSVVKII 1772
              D V+   ++G +SV+KI+
Sbjct: 486  QGDSVVALHRVGTASVIKIV 505

---

>O44006:KPYK_EIMTE Pyruvate kinase - Eimeria tenella|
          Length = 531

 Score =  265 bits (678), Expect = 4e-70
 Identities = 166/430 (38%), Positives = 248/430 (57%), Gaps = 4/430 (0%)
 Frame = +3

Query: 240  VRLASVLAPAKPKVFPS-LTKIVGTLGPNSHSVEVIEECLTAGMSVARFDFSWKDATYHQ 416
            +R++ +L   + + F +  TKIV T+GP+   V+ + + + AGM+V R +FS  D   H 
Sbjct: 39   IRMSQILEHHEDEDFSAHRTKIVCTMGPSCWDVDKMVQLIDAGMNVCRLNFSHGDHEAHG 98

Query: 417  ETLDNLRKAA-QNVKKLCPIMLDTVGPEIQVHNPTGGA-IELIGGNHVTITPDLSKAPSA 590
              + NL++A  Q   K   ++LDT GPEI+     G   IEL  G+ + I  D S   + 
Sbjct: 99   RVVKNLQEALKQRPGKRVALLLDTKGPEIRTGMLEGDKPIELHAGDMLKIVTDYSFVGNK 158

Query: 591  DILPIKFGDLAKVVKKGDTLFIGQYLFTGSETTSLWLEVMETSGEEVICFVKNTATLSGP 770
              +   +  L   VK G+T+ I           SL +EV+E   + V+  V N A + G 
Sbjct: 159  SCIACSYEKLPSSVKPGNTILIAD--------GSLSVEVVECGKDYVMTRVMNPAII-GN 209

Query: 771  IFTLHVSQVHISMPTLSEYDKQVISTWGLDNSVDIISLSHTRSSEDVRELRAFLQSHNLQ 950
               +++  V + +P + E DK  I  +G+    + I+ S  +S++DVR +R+ L +   +
Sbjct: 210  KKNMNLPGVKVDLPVIGEKDKNDILNFGIPMGCNFIAASFVQSADDVRYIRSILGTKG-R 268

Query: 951  DTQIYAKIENAEGLEHFDEILQEADGIIISRGDLGIDLPPERVFMSQKTGIHKCNMAGKP 1130
            + +I  KIEN EGL +FDEILQEADGI+I+RGDLG+++PPE+VF++QK  I KCN+AGKP
Sbjct: 269  NIKIIPKIENVEGLLNFDEILQEADGIMIARGDLGMEIPPEKVFLAQKMMISKCNVAGKP 328

Query: 1131 VI-ITRVVDSMIDNLRPTRAEATDVANAVLDGTDGILLGAETLRGQYPVDAVSTVGRICA 1307
            VI  T++++SM  N RPTRAEA DVANAVLDGTD ++L  ET  G +PV AV+ + R+C 
Sbjct: 329  VITATQMLESMTKNPRPTRAEAADVANAVLDGTDCVMLSGETANGSFPVQAVTVMSRVCF 388

Query: 1308 EAETVYNQSLHFKKVVRHVGEPMAHEEXXXXXXXXXXXXXXXXXIVVFTFSGRAARLVAK 1487
            EAE   +    F+   +    P+  +E                 I+  T +GR ARL+AK
Sbjct: 389  EAEGCIDYQQVFRATCQATMTPIDTQEAVARAAVETAQSINASLILALTETGRTARLIAK 448

Query: 1488 YRPPMPVLAV 1517
            YRP  P+LA+
Sbjct: 449  YRPMQPILAL 458

---

>P80885:KPYK_BACSU Pyruvate kinase - Bacillus subtilis|
          Length = 585

 Score =  261 bits (668), Expect = 6e-69
 Identities = 177/498 (35%), Positives = 271/498 (54%), Gaps = 4/498 (0%)
 Frame = +3

Query: 294  TKIVGTLGPNSHSVEVIEECLTAGMSVARFDFSWKDATYHQETLDNLRKAAQNVKKLCPI 473
            TKIV T+GP S S+E++ + + +GM+VAR +FS  D   H   + N+R+A++ + K   I
Sbjct: 4    TKIVCTIGPASESIEMLTKLMESGMNVARLNFSHGDFEEHGARIKNIREASKKLGKNVGI 63

Query: 474  MLDTVGPEIQVHNPTGGAIELIGGNHVTITPDLSKAPSADILPIKFGDLAKVVKKGDTLF 653
            +LDT GPEI+ H    G IEL  G  + I+ D     + D + + +  L   V++G T+ 
Sbjct: 64   LLDTKGPEIRTHTMENGGIELETGKELIISMD-EVVGTTDKISVTYEGLVHDVEQGSTIL 122

Query: 654  IGQYLFTGSETTSLWLEVMETSG--EEVICFVKNTATLSGPIFTLHVSQVHISMPTLSEY 827
            +   L        + LEV++      E+   V N  TL      ++V  V +++P ++E 
Sbjct: 123  LDDGL--------IGLEVLDVDAAKREIKTKVLNNGTLKNKK-GVNVPGVSVNLPGITEK 173

Query: 828  DKQVISTWGLDNSVDIISLSHTRSSEDVRELRAFLQSHNLQDTQIYAKIENAEGLEHFDE 1007
            D + I  +G++  VD I+ S  R S DV E+R  L+ HN QD QI  KIEN EG+++ D 
Sbjct: 174  DARDI-VFGIEQGVDFIAPSFIRRSTDVLEIRELLEEHNAQDIQIIPKIENQEGVDNIDA 232

Query: 1008 ILQEADGIIISRGDLGIDLPPERVFMSQKTGIHKCNMAGKPVI-ITRVVDSMIDNLRPTR 1184
            IL+ +DG++++RGDLG+++P E V + QK  I KCN  GKPVI  T+++DSM  N RPTR
Sbjct: 233  ILEVSDGLMVARGDLGVEIPAEEVPLVQKELIKKCNALGKPVITATQMLDSMQRNPRPTR 292

Query: 1185 AEATDVANAVLDGTDGILLGAETLRGQYPVDAVSTVGRICAEAETVYNQSLHFKKVVRHV 1364
            AEA+DVANA+ DGTD I+L  ET  G YPV+AV T+  I + +E   N      K    V
Sbjct: 293  AEASDVANAIFDGTDAIMLSGETAAGSYPVEAVQTMHNIASRSEEALNYKEILSKRRDQV 352

Query: 1365 GEPMAHEEXXXXXXXXXXXXXXXXXIVVFTFSGRAARLVAKYRPPMPVLAVVFPREGSDP 1544
            G  M   +                 IV  T SG  AR++AKYRP  P++AV         
Sbjct: 353  G--MTITDAIGQSVAHTAINLNAAAIVTPTESGHTARMIAKYRPQAPIVAV--------- 401

Query: 1545 SKWRSYGTTQARQCFSVRGVYPLMGSTDEAETGGLTKEAYGIKLALNYGRSVGIIKPYDR 1724
                +   + +R+   V GV+   G  + + T  + ++A  ++ +LN     GI+K  D 
Sbjct: 402  ----TVNDSISRKLALVSGVFAESGQ-NASSTDEMLEDA--VQKSLN----SGIVKHGDL 450

Query: 1725 VIIFE-KIGDSSVVKIIE 1775
            ++I    +G+S    +++
Sbjct: 451  IVITAGTVGESGTTNLMK 468

---

>P51181:KPYK_BACLI Pyruvate kinase - Bacillus licheniformis|
          Length = 585

 Score =  259 bits (661), Expect = 4e-68
 Identities = 160/411 (38%), Positives = 235/411 (57%), Gaps = 3/411 (0%)
 Frame = +3

Query: 294  TKIVGTLGPNSHSVEVIEECLTAGMSVARFDFSWKDATYHQETLDNLRKAAQNVKKLCPI 473
            TKIV T+GP S SVE + + + AGM+VAR +FS  D   H   + N+R+AA  + K   I
Sbjct: 4    TKIVCTIGPASESVEKLTQLMEAGMNVARLNFSHGDFEEHGARIKNIREAAGKLGKDIGI 63

Query: 474  MLDTVGPEIQVHNPTGGAIELIGGNHVTITPDLSKAPSADILPIKFGDLAKVVKKGDTLF 653
            +LDT GPEI+ H    G+IEL  G+ + ++ D     + D + + +  L   V  G T+ 
Sbjct: 64   LLDTKGPEIRTHTMENGSIELAAGSQLIVSMD-EVIGTPDKISVTYDGLIHDVSVGSTIL 122

Query: 654  IGQYLFTGSETTSLWLEVMETSGEEVICFVKNTATLSGPIFTLHVSQVHISMPTLSEYDK 833
            +   L  G E T +          E++  V N+ TL      ++V  V +++P ++E D 
Sbjct: 123  LDDGL-VGLEVTDI-----NKDKREIVTKVMNSGTLKNKK-GVNVPGVSVNLPGITEKDA 175

Query: 834  QVISTWGLDNSVDIISLSHTRSSEDVRELRAFLQSHNLQDTQIYAKIENAEGLEHFDEIL 1013
              I  +G++  VD I+ S  R   DV E+R  L+ HN  D QI  KIEN EG+++ D IL
Sbjct: 176  NDI-VFGIEQGVDFIAASFVRRPSDVLEIRELLEEHNAADIQIIPKIENQEGVDNIDAIL 234

Query: 1014 QEADGIIISRGDLGIDLPPERVFMSQKTGIHKCNMAGKPVI-ITRVVDSMIDNLRPTRAE 1190
            + +DG++++RGDLG+++P E V + QK  I KCN  GKPVI  T+++DSM  N RPTRAE
Sbjct: 235  EVSDGLMVARGDLGVEIPAEEVPLVQKELIKKCNALGKPVITATQMLDSMQRNPRPTRAE 294

Query: 1191 ATDVANAVLDGTDGILLGAETLRGQYPVDAVSTVGRICAEAETVYNQSLHFKKVV--RHV 1364
            A+DVANA+ DGTD I+L  ET  G YPV+AV T+  I + +E    ++L+ KK++  R  
Sbjct: 295  ASDVANAIFDGTDAIMLSGETAAGNYPVEAVQTMHNIASRSE----EALNHKKILSARSK 350

Query: 1365 GEPMAHEEXXXXXXXXXXXXXXXXXIVVFTFSGRAARLVAKYRPPMPVLAV 1517
               M+  +                 IV  T SG  AR+++KYRP  P++AV
Sbjct: 351  QVSMSITDAIGQSVAHTAINLDVNAIVTPTESGHTARMISKYRPQAPIVAV 401

---

>P51182:KPYK_BACPY Pyruvate kinase - Bacillus psychrophilus (Sporosarcina psychrophila)|
          Length = 586

 Score =  256 bits (654), Expect = 3e-67
 Identities = 160/455 (35%), Positives = 254/455 (55%), Gaps = 13/455 (2%)
 Frame = +3

Query: 294  TKIVGTLGPNSHSVEVIEECLTAGMSVARFDFSWKDATYHQETLDNLRKAAQNVKKLCPI 473
            TKIV T+GP S S E++E+ + AGM+VAR +FS  +   H+  +D++RK A+   K+  I
Sbjct: 4    TKIVCTIGPASESPELLEQLIEAGMNVARLNFSHGNHAEHKARIDSIRKVAREKGKVVGI 63

Query: 474  MLDTVGPEIQVHNPTGGAIELIGGNHVTITPDLSKAPSADILPIKFGDLAKVVKKGDTLF 653
            +LDT GPEI+ H+   G +EL+ G  + I+    +  + D+  + +  L + V +G  + 
Sbjct: 64   LLDTKGPEIRTHSMMNGKLELVTGQKIDISMTQVEGNN-DVFSVSYDKLIEDVNEGSVIL 122

Query: 654  IGQYLFTGSETTSLWLEVMETSGEEVICFVKNTATLSGPIFT----LHVSQVHISMPTLS 821
            +   L             +E +G++V   + +T  ++    +    +++  V + +P ++
Sbjct: 123  LDDGLIQ-----------LEVTGKDVARGLIHTLIINSGSLSNNKGVNIPGVSVQLPGMT 171

Query: 822  EYDKQVISTWGLDNSVDIISLSHTRSSEDVRELRAFLQSHNLQDTQIYAKIENAEGLEHF 1001
            E D + I  +G+   VD I+ S  R + DV E+RA L+++N  + QI  KIEN EG+++ 
Sbjct: 172  EKDAEDI-LFGIREGVDFIAASFVRRASDVMEIRALLENNNGSNLQIIPKIENQEGVDNI 230

Query: 1002 DEILQEADGIIISRGDLGIDLPPERVFMSQKTGIHKCNMAGKPVI-ITRVVDSMIDNLRP 1178
            DEIL  +DG++++RGDLG+++PPE V + QK  I KCN AGKPVI  T+++DSM  N RP
Sbjct: 231  DEILNVSDGLMVARGDLGVEIPPEEVPLVQKNLIEKCNQAGKPVITATQMLDSMQRNPRP 290

Query: 1179 TRAEATDVANAVLDGTDGILLGAETLRGQYPVDAVSTVGRIC--AEAETVYNQSLHFKKV 1352
            TRAEA+DVANA+ DGTD I+L  ET  G YPV++V T+ RI    EA   Y   +  ++ 
Sbjct: 291  TRAEASDVANAIFDGTDAIMLSGETAAGIYPVESVQTMDRIALTTEAAIDYRSVVSTRRR 350

Query: 1353 VRH------VGEPMAHEEXXXXXXXXXXXXXXXXXIVVFTFSGRAARLVAKYRPPMPVLA 1514
             +H      +G+  A+                   ++  T SG  A+++AKYRP  PV+A
Sbjct: 351  EKHGNMTEAIGQAAAY----------TAINLKVKAVLAPTESGHTAKMIAKYRPGCPVIA 400

Query: 1515 VVFPREGSDPSKWRSYGTTQARQCFSVRGVYPLMG 1619
            V      S             R+   + GVYP++G
Sbjct: 401  VTSSEMCS-------------RKLSLIWGVYPIVG 422

---

>P77983:KPYK1_SALTY Pyruvate kinase I - Salmonella typhimurium|
          Length = 470

 Score =  253 bits (647), Expect = 2e-66
 Identities = 157/410 (38%), Positives = 227/410 (55%), Gaps = 2/410 (0%)
 Frame = +3

Query: 294  TKIVGTLGPNSHSVEVIEECLTAGMSVARFDFSWKDATYHQETLDNLRKAAQNVKKLCPI 473
            TKIV T+GP + S E++ + L AGM+V R +FS  D   H + + NLR       K   I
Sbjct: 4    TKIVCTIGPKTESEEMLSKMLDAGMNVMRLNFSHGDYAEHGQRIQNLRNVMSKTGKKAAI 63

Query: 474  MLDTVGPEIQVHNPTGGA-IELIGGNHVTITPDLSKAPSADILPIKFGDLAKVVKKGDTL 650
            +LDT GPEI+     GG  + L  G   T T D S   + +I+ + +      +  G+T+
Sbjct: 64   LLDTKGPEIRTIKLEGGNDVSLKAGQTFTFTTDKSVVGNNEIVAVTYEGFTSDLSVGNTV 123

Query: 651  FIGQYLFTGSETTSLWLEVMETSGEEVICFVKNTATLSGPIFTLHVSQVHISMPTLSEYD 830
             +   L        + +EV    G +VIC V N   L G    +++  V I++P L+E D
Sbjct: 124  LVDDGL--------IGMEVTAIEGNKVICKVLNNGDL-GENKGVNLPGVSIALPALAEKD 174

Query: 831  KQVISTWGLDNSVDIISLSHTRSSEDVRELRAFLQSHNLQDTQIYAKIENAEGLEHFDEI 1010
            KQ +  +G +  VD ++ S  R   DV E+R  L++H  ++ QI +KIEN EGL +FDEI
Sbjct: 175  KQDL-IFGCEQGVDFVAASFIRKRSDVVEIREHLKAHGGENIQIISKIENQEGLNNFDEI 233

Query: 1011 LQEADGIIISRGDLGIDLPPERVFMSQKTGIHKCNMAGKPVI-ITRVVDSMIDNLRPTRA 1187
            L+ +DGI+++RGDLG+++P E V  +QK  I KC  A K VI  T+++DSMI N RPTRA
Sbjct: 234  LEASDGIMVARGDLGVEIPVEEVIFAQKMMIEKCIRARKVVITATQMLDSMIKNPRPTRA 293

Query: 1188 EATDVANAVLDGTDGILLGAETLRGQYPVDAVSTVGRICAEAETVYNQSLHFKKVVRHVG 1367
            EA DVANA+LDGTD ++L  E+ +G+YP++AVS +  IC   + V N  L +    R   
Sbjct: 294  EAGDVANAILDGTDAVMLSGESAKGKYPLEAVSIMATICERTDRVMNSRLDYNNDSR--- 350

Query: 1368 EPMAHEEXXXXXXXXXXXXXXXXXIVVFTFSGRAARLVAKYRPPMPVLAV 1517
              +   E                 IVV T  G++AR V KY P   +LA+
Sbjct: 351  -KLRITEAVCRGAVETAEKLEAPLIVVATQGGKSARAVRKYFPDATILAL 399

---

>Q8Z6K2:KPYK1_SALTI Pyruvate kinase I - Salmonella typhi|
          Length = 470

 Score =  253 bits (647), Expect = 2e-66
 Identities = 157/410 (38%), Positives = 227/410 (55%), Gaps = 2/410 (0%)
 Frame = +3

Query: 294  TKIVGTLGPNSHSVEVIEECLTAGMSVARFDFSWKDATYHQETLDNLRKAAQNVKKLCPI 473
            TKIV T+GP + S E++ + L AGM+V R +FS  D   H + + NLR       K   I
Sbjct: 4    TKIVCTIGPKTESEEMLSKMLDAGMNVMRLNFSHGDYAEHGQRIQNLRNVMSKTGKKAAI 63

Query: 474  MLDTVGPEIQVHNPTGGA-IELIGGNHVTITPDLSKAPSADILPIKFGDLAKVVKKGDTL 650
            +LDT GPEI+     GG  + L  G   T T D S   + +I+ + +      +  G+T+
Sbjct: 64   LLDTKGPEIRTIKLEGGNDVSLKAGQTFTFTTDKSVVGNNEIVAVTYEGFTSDLSVGNTV 123

Query: 651  FIGQYLFTGSETTSLWLEVMETSGEEVICFVKNTATLSGPIFTLHVSQVHISMPTLSEYD 830
             +   L        + +EV    G +VIC V N   L G    +++  V I++P L+E D
Sbjct: 124  LVDDGL--------IGMEVTAIEGNKVICKVLNNGDL-GENKGVNLPGVSIALPALAEKD 174

Query: 831  KQVISTWGLDNSVDIISLSHTRSSEDVRELRAFLQSHNLQDTQIYAKIENAEGLEHFDEI 1010
            KQ +  +G +  VD ++ S  R   DV E+R  L++H  ++ QI +KIEN EGL +FDEI
Sbjct: 175  KQDL-IFGCEQGVDFVAASFIRKRSDVVEIREHLKAHGGENIQIISKIENQEGLNNFDEI 233

Query: 1011 LQEADGIIISRGDLGIDLPPERVFMSQKTGIHKCNMAGKPVI-ITRVVDSMIDNLRPTRA 1187
            L+ +DGI+++RGDLG+++P E V  +QK  I KC  A K VI  T+++DSMI N RPTRA
Sbjct: 234  LEASDGIMVARGDLGVEIPVEEVIFAQKMMIEKCIRARKVVITATQMLDSMIKNPRPTRA 293

Query: 1188 EATDVANAVLDGTDGILLGAETLRGQYPVDAVSTVGRICAEAETVYNQSLHFKKVVRHVG 1367
            EA DVANA+LDGTD ++L  E+ +G+YP++AVS +  IC   + V N  L +    R   
Sbjct: 294  EAGDVANAILDGTDAVMLSGESAKGKYPLEAVSIMATICERTDRVMNSRLDYNNDSR--- 350

Query: 1368 EPMAHEEXXXXXXXXXXXXXXXXXIVVFTFSGRAARLVAKYRPPMPVLAV 1517
              +   E                 IVV T  G++AR V KY P   +LA+
Sbjct: 351  -KLRITEAVCRGAVETAEKLKAPLIVVATQGGKSARAVRKYFPDATILAL 399

---

>Q02499:KPYK_BACST Pyruvate kinase - Bacillus stearothermophilus (Geobacillus|
            stearothermophilus)
          Length = 587

 Score =  253 bits (645), Expect = 3e-66
 Identities = 172/493 (34%), Positives = 262/493 (53%), Gaps = 13/493 (2%)
 Frame = +3

Query: 294  TKIVGTLGPNSHSVEVIEECLTAGMSVARFDFSWKDATYHQETLDNLRKAAQNVKKLCPI 473
            TKIV T+GP S SV+ + + + AGM+VAR +FS  D   H   + N+R+AA+   +   I
Sbjct: 5    TKIVCTIGPASESVDKLVQLMEAGMNVARLNFSHGDHEEHGRRIANIREAAKRTGRTVAI 64

Query: 474  MLDTVGPEIQVHNPTGGAIELIGGNHVTITPDLSKAPSADILPIKFGDLAKVVKKGDTLF 653
            +LDT GPEI+ HN   GAIEL  G+ + I+       + + + + +  L       D + 
Sbjct: 65   LLDTKGPEIRTHNMENGAIELKEGSKLVISMS-EVLGTPEKISVTYPSLI------DDVS 117

Query: 654  IGQYLFTGSETTSLWLEVMETSGEEVICFVKNTATLSGPIFTLHVSQVHISMPTLSEYDK 833
            +G  +       SL +  ++    E++  V N   L      ++V  V +++P ++E D+
Sbjct: 118  VGAKILLDDGLISLEVNAVDKQAGEIVTTVLNGGVLKNKK-GVNVPGVKVNLPGITEKDR 176

Query: 834  QVISTWGLDNSVDIISLSHTRSSEDVRELRAFLQSHNLQDTQIYAKIENAEGLEHFDEIL 1013
              I  +G+   +D I+ S  R + DV E+R  L++H+    QI AKIEN EG+ + DEIL
Sbjct: 177  ADI-LFGIRQGIDFIAASFVRRASDVLEIRELLEAHDALHIQIIAKIENEEGVANIDEIL 235

Query: 1014 QEADGIIISRGDLGIDLPPERVFMSQKTGIHKCNMAGKPVI-ITRVVDSMIDNLRPTRAE 1190
            + ADG++++RGDLG+++P E V + QK  I KCNM GKPVI  T+++DSM  N RPTRAE
Sbjct: 236  EAADGLMVARGDLGVEIPAEEVPLIQKLLIKKCNMLGKPVITATQMLDSMQRNPRPTRAE 295

Query: 1191 ATDVANAVLDGTDGILLGAETLRGQYPVDAVSTVGRICAEAETVYNQSLHFKKVVRH--- 1361
            A+DVANA+ DGTD ++L  ET  GQYPV+AV T+ +I    E    Q+L  + ++     
Sbjct: 296  ASDVANAIFDGTDAVMLSGETAAGQYPVEAVKTMHQIALRTE----QALEHRDILSQRTK 351

Query: 1362 ---------VGEPMAHEEXXXXXXXXXXXXXXXXXIVVFTFSGRAARLVAKYRPPMPVLA 1514
                     +G+ +AH                   IV  T SG+  ++VAKYRP  P++A
Sbjct: 352  ESQTTITDAIGQSVAH----------TALNLDVAAIVTPTVSGKTPQMVAKYRPKAPIIA 401

Query: 1515 VVFPREGSDPSKWRSYGTTQARQCFSVRGVYPLMGSTDEAETGGLTKEAYGIKLALNYGR 1694
            V             +     +R+   V GVY     T EA     T E   + +A++   
Sbjct: 402  V-------------TSNEAVSRRLALVWGVY-----TKEAPHVNTTDEM--LDVAVDAAV 441

Query: 1695 SVGIIKPYDRVII 1733
              G++K  D V+I
Sbjct: 442  RSGLVKHGDLVVI 454

---

>P11980:KPYM_RAT Pyruvate kinase isozymes M1/M2 - Rattus norvegicus (Rat)|
          Length = 531

 Score =  252 bits (644), Expect = 4e-66
 Identities = 171/492 (34%), Positives = 265/492 (53%), Gaps = 12/492 (2%)
 Frame = +3

Query: 294  TKIVGTLGPNSHSVEVIEECLTAGMSVARFDFSWKDATYHQETLDNLRKAAQN------V 455
            T I+ T+GP S SVE+++E + +GM+VAR +FS     YH ET+ N+R A ++      +
Sbjct: 45   TGIICTIGPASRSVEMLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRAATESFASDPIL 104

Query: 456  KKLCPIMLDTVGPEIQVHNPTGGA---IELIGGNHVTITPDLSKAPSAD--ILPIKFGDL 620
             +   + LDT GPEI+     G     +EL  G  + IT D +     D  IL + + ++
Sbjct: 105  YRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNI 164

Query: 621  AKVVKKGDTLFIGQYLFTGSETTSLWLEVMETSGEEVICFVKNTATLSGPIFTLHVSQVH 800
             KVV+ G  +++   L +        L+V E   + ++  V+N  +L G    +++    
Sbjct: 165  CKVVEVGSKIYVDDGLIS--------LQVKEKGADYLVTEVENGGSL-GSKKGVNLPGAA 215

Query: 801  ISMPTLSEYDKQVISTWGLDNSVDIISLSHTRSSEDVRELRAFLQSHNLQDTQIYAKIEN 980
            + +P +SE D Q +  +G++  VD++  S  R + DV E+R  L     ++ +I +KIEN
Sbjct: 216  VDLPAVSEKDIQDLK-FGVEQDVDMVFASFIRKAADVHEVRKVLGEKG-KNIKIISKIEN 273

Query: 981  AEGLEHFDEILQEADGIIISRGDLGIDLPPERVFMSQKTGIHKCNMAGKPVI-ITRVVDS 1157
             EG+  FDEIL+ +DGI+++RGDLGI++P E+VF++QK  I +CN AGKPVI  T++++S
Sbjct: 274  HEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLES 333

Query: 1158 MIDNLRPTRAEATDVANAVLDGTDGILLGAETLRGQYPVDAVSTVGRICAEAETVYNQSL 1337
            MI   RPTRAE +DVANAVLDG D I+L  ET +G YP++AV     I  EAE      L
Sbjct: 334  MIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAVFHRL 393

Query: 1338 HFKKVVRHVGEPMAHEEXXXXXXXXXXXXXXXXXIVVFTFSGRAARLVAKYRPPMPVLAV 1517
             F+++ R   +     E                 ++V T SGR+A  VA+YRP  P++AV
Sbjct: 394  LFEELARASSQSTDPLEAMAMGSVEASYKCLAAALIVLTESGRSAHQVARYRPRAPIIAV 453

Query: 1518 VFPREGSDPSKWRSYGTTQARQCFSVRGVYPLMGSTDEAETGGLTKEAYGIKLALNYGRS 1697
                         +     ARQ    RG++P++   D             + LA+N G++
Sbjct: 454  -------------TRNPQTARQAHLYRGIFPVL-CKDAVLDAWAEDVDLRVNLAMNVGKA 499

Query: 1698 VGIIKPYDRVII 1733
             G  K  D VI+
Sbjct: 500  RGFFKKGDVVIV 511

---

>P0AD61:KPYK1_ECOLI Pyruvate kinase I - Escherichia coli|
          Length = 470

 Score =  252 bits (644), Expect = 4e-66
 Identities = 156/410 (38%), Positives = 227/410 (55%), Gaps = 2/410 (0%)
 Frame = +3

Query: 294  TKIVGTLGPNSHSVEVIEECLTAGMSVARFDFSWKDATYHQETLDNLRKAAQNVKKLCPI 473
            TKIV T+GP + S E++ + L AGM+V R +FS  D   H + + NLR       K   I
Sbjct: 4    TKIVCTIGPKTESEEMLAKMLDAGMNVMRLNFSHGDYAEHGQRIQNLRNVMSKTGKTAAI 63

Query: 474  MLDTVGPEIQVHNPTGGA-IELIGGNHVTITPDLSKAPSADILPIKFGDLAKVVKKGDTL 650
            +LDT GPEI+     GG  + L  G   T T D S   +++++ + +      +  G+T+
Sbjct: 64   LLDTKGPEIRTMKLEGGNDVSLKAGQTFTFTTDKSVIGNSEMVAVTYEGFTTDLSVGNTV 123

Query: 651  FIGQYLFTGSETTSLWLEVMETSGEEVICFVKNTATLSGPIFTLHVSQVHISMPTLSEYD 830
             +   L        + +EV    G +VIC V N   L G    +++  V I++P L+E D
Sbjct: 124  LVDDGL--------IGMEVTAIEGNKVICKVLNNGDL-GENKGVNLPGVSIALPALAEKD 174

Query: 831  KQVISTWGLDNSVDIISLSHTRSSEDVRELRAFLQSHNLQDTQIYAKIENAEGLEHFDEI 1010
            KQ +  +G +  VD ++ S  R   DV E+R  L++H  ++  I +KIEN EGL +FDEI
Sbjct: 175  KQDL-IFGCEQGVDFVAASFIRKRSDVIEIREHLKAHGGENIHIISKIENQEGLNNFDEI 233

Query: 1011 LQEADGIIISRGDLGIDLPPERVFMSQKTGIHKCNMAGKPVI-ITRVVDSMIDNLRPTRA 1187
            L+ +DGI+++RGDLG+++P E V  +QK  I KC  A K VI  T+++DSMI N RPTRA
Sbjct: 234  LEASDGIMVARGDLGVEIPVEEVIFAQKMMIEKCIRARKVVITATQMLDSMIKNPRPTRA 293

Query: 1188 EATDVANAVLDGTDGILLGAETLRGQYPVDAVSTVGRICAEAETVYNQSLHFKKVVRHVG 1367
            EA DVANA+LDGTD ++L  E+ +G+YP++AVS +  IC   + V N  L F    R   
Sbjct: 294  EAGDVANAILDGTDAVMLSGESAKGKYPLEAVSIMATICERTDRVMNSRLEFNNDNR--- 350

Query: 1368 EPMAHEEXXXXXXXXXXXXXXXXXIVVFTFSGRAARLVAKYRPPMPVLAV 1517
              +   E                 IVV T  G++AR V KY P   +LA+
Sbjct: 351  -KLRITEAVCRGAVETAEKLDAPLIVVATQGGKSARAVRKYFPDATILAL 399

---

>P0AD62:KPYK1_ECO57 Pyruvate kinase I - Escherichia coli O157:H7|
          Length = 470

 Score =  252 bits (644), Expect = 4e-66
 Identities = 156/410 (38%), Positives = 227/410 (55%), Gaps = 2/410 (0%)
 Frame = +3

Query: 294  TKIVGTLGPNSHSVEVIEECLTAGMSVARFDFSWKDATYHQETLDNLRKAAQNVKKLCPI 473
            TKIV T+GP + S E++ + L AGM+V R +FS  D   H + + NLR       K   I
Sbjct: 4    TKIVCTIGPKTESEEMLAKMLDAGMNVMRLNFSHGDYAEHGQRIQNLRNVMSKTGKTAAI 63

Query: 474  MLDTVGPEIQVHNPTGGA-IELIGGNHVTITPDLSKAPSADILPIKFGDLAKVVKKGDTL 650
            +LDT GPEI+     GG  + L  G   T T D S   +++++ + +      +  G+T+
Sbjct: 64   LLDTKGPEIRTMKLEGGNDVSLKAGQTFTFTTDKSVIGNSEMVAVTYEGFTTDLSVGNTV 123

Query: 651  FIGQYLFTGSETTSLWLEVMETSGEEVICFVKNTATLSGPIFTLHVSQVHISMPTLSEYD 830
             +   L        + +EV    G +VIC V N   L G    +++  V I++P L+E D
Sbjct: 124  LVDDGL--------IGMEVTAIEGNKVICKVLNNGDL-GENKGVNLPGVSIALPALAEKD 174

Query: 831  KQVISTWGLDNSVDIISLSHTRSSEDVRELRAFLQSHNLQDTQIYAKIENAEGLEHFDEI 1010
            KQ +  +G +  VD ++ S  R   DV E+R  L++H  ++  I +KIEN EGL +FDEI
Sbjct: 175  KQDL-IFGCEQGVDFVAASFIRKRSDVIEIREHLKAHGGENIHIISKIENQEGLNNFDEI 233

Query: 1011 LQEADGIIISRGDLGIDLPPERVFMSQKTGIHKCNMAGKPVI-ITRVVDSMIDNLRPTRA 1187
            L+ +DGI+++RGDLG+++P E V  +QK  I KC  A K VI  T+++DSMI N RPTRA
Sbjct: 234  LEASDGIMVARGDLGVEIPVEEVIFAQKMMIEKCIRARKVVITATQMLDSMIKNPRPTRA 293

Query: 1188 EATDVANAVLDGTDGILLGAETLRGQYPVDAVSTVGRICAEAETVYNQSLHFKKVVRHVG 1367
            EA DVANA+LDGTD ++L  E+ +G+YP++AVS +  IC   + V N  L F    R   
Sbjct: 294  EAGDVANAILDGTDAVMLSGESAKGKYPLEAVSIMATICERTDRVMNSRLEFNNDNR--- 350

Query: 1368 EPMAHEEXXXXXXXXXXXXXXXXXIVVFTFSGRAARLVAKYRPPMPVLAV 1517
              +   E                 IVV T  G++AR V KY P   +LA+
Sbjct: 351  -KLRITEAVCRGAVETAEKLDAPLIVVATQGGKSARAVRKYFPDATILAL 399

---

>P11979:KPYM_FELCA Pyruvate kinase isozyme M1 - Felis silvestris catus (Cat)|
          Length = 531

 Score =  252 bits (643), Expect = 5e-66
 Identities = 173/499 (34%), Positives = 268/499 (53%), Gaps = 12/499 (2%)
 Frame = +3

Query: 273  PKVFPSLTKIVGTLGPNSHSVEVIEECLTAGMSVARFDFSWKDATYHQETLDNLRKAAQN 452
            P +    T I+ T+GP S SVE+++E + +GM+VAR +FS     YH ET+ N+R A ++
Sbjct: 38   PPITARNTGIICTIGPASRSVEILKEMIKSGMNVARLNFSHGTHEYHAETIKNVRAATES 97

Query: 453  VK------KLCPIMLDTVGPEIQVHNPTGGA---IELIGGNHVTITPDLSKAPSAD--IL 599
                    +   + LDT GPEI+     G     +EL  G  + IT D +     D  +L
Sbjct: 98   FASDPIRYRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENVL 157

Query: 600  PIKFGDLAKVVKKGDTLFIGQYLFTGSETTSLWLEVMETSGEEVICFVKNTATLSGPIFT 779
             + + ++ KVV+ G  +++   L +        L V E   + ++  V+N  +L G    
Sbjct: 158  WLDYKNICKVVEVGSKVYVDDGLIS--------LLVKEKGADFLVTEVENGGSL-GSKKG 208

Query: 780  LHVSQVHISMPTLSEYDKQVISTWGLDNSVDIISLSHTRSSEDVRELRAFLQSHNLQDTQ 959
            +++    + +P +SE D Q +  +G++  VD++  S  R + DV E+R  L     ++ +
Sbjct: 209  VNLPGAAVDLPAVSEKDIQDLK-FGVEQDVDMVFASFIRKASDVHEVRKVLGEKG-KNIK 266

Query: 960  IYAKIENAEGLEHFDEILQEADGIIISRGDLGIDLPPERVFMSQKTGIHKCNMAGKPVI- 1136
            I +KIEN EG+  FDEIL+ +DGI+++RGDLGI++P E+VF++QK  I +CN AGKPVI 
Sbjct: 267  IISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVIC 326

Query: 1137 ITRVVDSMIDNLRPTRAEATDVANAVLDGTDGILLGAETLRGQYPVDAVSTVGRICAEAE 1316
             T++++SMI   RPTRAE +DVANAVLDG D I+L  ET +G YP++AV     I  EAE
Sbjct: 327  ATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAE 386

Query: 1317 TVYNQSLHFKKVVRHVGEPMAHEEXXXXXXXXXXXXXXXXXIVVFTFSGRAARLVAKYRP 1496
                    F+++VR         E                 ++V T SGR+A  VA+YRP
Sbjct: 387  AAMFHRKLFEELVRGSSHSTDLMEAMAMGSVEASYKCLAAALIVLTESGRSAHQVARYRP 446

Query: 1497 PMPVLAVVFPREGSDPSKWRSYGTTQARQCFSVRGVYPLMGSTDEAETGGLTKEAYGIKL 1676
              P++AV            R++ T  ARQ    RG++P++   D  +          + L
Sbjct: 447  RAPIIAVT-----------RNHQT--ARQAHLYRGIFPVV-CKDPVQEAWAEDVDLRVNL 492

Query: 1677 ALNYGRSVGIIKPYDRVII 1733
            A+N G++ G  K  D VI+
Sbjct: 493  AMNVGKARGFFKHGDVVIV 511

---

>Q49YC7:KPYK_STAS1 Pyruvate kinase - Staphylococcus saprophyticus subsp. saprophyticus|
            (strain ATCC 15305 / DSM 20229)
          Length = 586

 Score =  251 bits (641), Expect = 9e-66
 Identities = 161/451 (35%), Positives = 247/451 (54%), Gaps = 10/451 (2%)
 Frame = +3

Query: 294  TKIVGTLGPNSHSVEVIEECLTAGMSVARFDFSWKDATYHQETLDNLRKAAQNVKKLCPI 473
            TKIV T+GP S S E++E+ + AGM+VAR +FS  D   H+  +D +RK ++ + K   I
Sbjct: 4    TKIVCTIGPASESEEMLEKLIKAGMNVARLNFSHGDQAEHKARIDTIRKVSKRLGKTVAI 63

Query: 474  MLDTVGPEIQVHNPTGGAIELIGGNHVTIT-PDLSKAPSADILPIKFGDLAKVVKKGDTL 650
            +LDT GPEI+ HN   G IEL  G+ VT++  ++   P      + + +L   V++G   
Sbjct: 64   LLDTKGPEIRTHNMKDGLIELEKGSEVTVSMTEVEGTPEK--FSVTYENLINDVEEGS-- 119

Query: 651  FIGQYLFTGSETTSLWLEVMETSGEEVICFVKNTATLSGPIFTLHVSQVHISMPTLSEYD 830
                Y+        L ++ ++ +  EV+C V NT  L      +++  V +S+P +++ D
Sbjct: 120  ----YILLDDGLIELQVKSIDKANGEVLCDVLNTGELKNKK-GVNLPGVKVSLPGITDKD 174

Query: 831  KQVISTWGLDNSVDIISLSHTRSSEDVRELRAFLQSHNLQDTQIYAKIENAEGLEHFDEI 1010
               I+ +G+   VD I+ S  R   DV ++R  L++   ++  I  KIEN EG+++  EI
Sbjct: 175  ADDIN-FGISEGVDFIAASFVRRPSDVLDIRKLLEAKQNKNISIIPKIENQEGIDNIKEI 233

Query: 1011 LQEADGIIISRGDLGIDLPPERVFMSQKTGIHKCNMAGKPVI-ITRVVDSMIDNLRPTRA 1187
            L+ +DG++++RGD+G+++PPE V M QK  I +CN  GKPVI  T+++DSM  N R TRA
Sbjct: 234  LEVSDGLMVARGDMGVEIPPESVPMVQKDLIRQCNKLGKPVITATQMLDSMQRNPRATRA 293

Query: 1188 EATDVANAVLDGTDGILLGAETLRGQYPVDAVSTVGRICAEAETV--YNQSLHFK----- 1346
            EA+DVANA+ DGTD ++L  ET  GQYP +AV T+  I   AE    Y + L  +     
Sbjct: 294  EASDVANAIYDGTDAVMLSGETAAGQYPEEAVKTMRNIAVSAEAAQDYKKLLSDRTKLVE 353

Query: 1347 -KVVRHVGEPMAHEEXXXXXXXXXXXXXXXXXIVVFTFSGRAARLVAKYRPPMPVLAVVF 1523
              +V  +G  +AH                   IV  T SG  AR ++KYRP   ++AV  
Sbjct: 354  TSLVNAIGVSVAH----------TALNLNVKAIVAATESGSTARTISKYRPQSDIIAVTP 403

Query: 1524 PREGSDPSKWRSYGTTQARQCFSVRGVYPLM 1616
              E              ARQC  V G++P++
Sbjct: 404  NAE-------------TARQCALVWGIFPVV 421

---

>Q29536:KPYR_CANFA Pyruvate kinase isozyme R - Canis familiaris (Dog)|
          Length = 519

 Score =  249 bits (637), Expect = 3e-65
 Identities = 175/493 (35%), Positives = 273/493 (55%), Gaps = 13/493 (2%)
 Frame = +3

Query: 294  TKIVGTLGPNSHSVEVIEECLTAGMSVARFDFSWKDATYHQETLDNLRKAAQNVK----- 458
            T I+ T+GP SHSVE ++E + AGM++AR +FS     YH +++ N+R+A ++       
Sbjct: 33   TSIIATIGPASHSVERLKEMIKAGMNIARLNFSHGSHEYHAQSIANIREAVESFATSPLG 92

Query: 459  -KLCPIMLDTVGPEIQVHNPTGGA---IELIGGNHVTIT--PDLSKAPSADILPIKFGDL 620
             +   I LDT GPEI+     GG    +EL+ G+ V +T  P       A  + + + ++
Sbjct: 93   YRPVAIALDTKGPEIRTGVLKGGPETEVELVKGSWVLVTVDPAFRTLGDAHTVWVDYPNI 152

Query: 621  AKVVKKGDTLFIGQYLFTGSETTSLWLEVMETSGEEVICFVKNTATLSGPIFTLHVSQVH 800
             KVV  G  +FI   L       SL ++ ++  G E    V+N   L G    +++    
Sbjct: 153  VKVVPVGGRIFIDDGLI------SLQVKKIDRKGLETQ--VENGGLL-GSRKGVNLPGAE 203

Query: 801  ISMPTLSEYDKQVISTWGLDNSVDIISLSHTRSSEDVRELRAFLQSHNLQDTQIYAKIEN 980
            + +P LSE D Q +  +G++++VDI+  S  R + DV  +RA L     +  +I +KIEN
Sbjct: 204  VDLPGLSEQDAQDLR-FGVEHNVDIVFASFVRKASDVAAIRAALGPEG-RTIKIISKIEN 261

Query: 981  AEGLEHFDEILQEADGIIISRGDLGIDLPPERVFMSQKTGIHKCNMAGKPVI-ITRVVDS 1157
             EG++ FDEIL+ +DGI+++RGDLGI++P E+VF++QK  I +CN+AGKPV+  T++++S
Sbjct: 262  HEGVKKFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLES 321

Query: 1158 MIDNLRPTRAEATDVANAVLDGTDGILLGAETLRGQYPVDAVSTVGRICAEAE-TVYNQS 1334
            MI   RPTRAE +DVANAVLDG D I+L  ET +G++PV+AV    RI  EAE  VY++ 
Sbjct: 322  MITKPRPTRAETSDVANAVLDGADCIMLSGETAKGKFPVEAVKMQHRIAREAEAAVYHRQ 381

Query: 1335 LHFKKVVRHVGEPMAHEEXXXXXXXXXXXXXXXXXIVVFTFSGRAARLVAKYRPPMPVLA 1514
            L F+++ R         E                 I+V T +GR+A+L+++YRP   V+A
Sbjct: 382  L-FEELRRAAPLSRDPTEVTAIATVEAAFKCCAAAIIVLTKTGRSAQLLSRYRPRAAVIA 440

Query: 1515 VVFPREGSDPSKWRSYGTTQARQCFSVRGVYPLMGSTDEAETGGLTKEAYGIKLALNYGR 1694
            V             +     ARQ    RGV+PL+ S +  E          ++  +  G+
Sbjct: 441  V-------------TRSAQAARQAHLCRGVFPLLYS-EPPEAIWADDVDRRVQFGIESGK 486

Query: 1695 SVGIIKPYDRVII 1733
              G ++  D VI+
Sbjct: 487  LRGFLRVGDLVIV 499

---

>Q27788:KPYK_TRYBO Pyruvate kinase - Trypanoplasma borreli|
          Length = 498

 Score =  249 bits (636), Expect = 3e-65
 Identities = 162/489 (33%), Positives = 260/489 (53%), Gaps = 3/489 (0%)
 Frame = +3

Query: 273  PKVFPSLTKIVGTLGPNSHSVEVIEECLTAGMSVARFDFSWKDATYHQETLDNLRKAAQN 452
            P +F S  KI+ T+GP+S SVEV+++ + AG++VAR +FS     YHQ+T+DN+RKAA  
Sbjct: 19   PALFRS-NKIICTIGPSSQSVEVLKDLMKAGLNVARMNFSHGTYEYHQKTIDNVRKAASE 77

Query: 453  VKKLCPIMLDTVGPEIQVHNPTGGAIELIGGNHVTITPD--LSKAPSADILPIKFGDLAK 626
            +     I LDT GPEI+      G + +     V +T D    +  +A+   + + ++ K
Sbjct: 78   LGIHVGIALDTKGPEIRTGLFPAGDVVIEAHKTVILTTDETFKEKGTAEKFYVDYMNITK 137

Query: 627  VVKKGDTLFIGQYLFTGSETTSLWLEVMETSGEEVICFVKNTATLSGPIFTLHVSQVHIS 806
            VV  G  +F+   L        L L V++ SG+++ C  +NT T+S     +++    + 
Sbjct: 138  VVPVGGHIFVDDGL--------LDLIVVKISGKDIECVAQNTHTISNR-KGINLPNADVD 188

Query: 807  MPTLSEYDKQVISTWGLDNSVDIISLSHTRSSEDVRELRAFLQSHNLQDTQIYAKIENAE 986
            +P +SE D   +  +G  N VD +  S  R+++ V E+R            + AKIEN +
Sbjct: 189  LPAVSEKDLMDLQ-FGAKNRVDFVFASFIRNADQVNEVRQAFGG----KIAVIAKIENYQ 243

Query: 987  GLEHFDEILQEADGIIISRGDLGIDLPPERVFMSQKTGIHKCNMAGKPVI-ITRVVDSMI 1163
            G+++ D I+  ADGI+++RGDLG+++P E+V ++QK  + KCN  GK VI  T+++DSM 
Sbjct: 244  GIDNIDAIIDAADGIMVARGDLGVEIPAEKVVIAQKMIMSKCNKVGKTVICATQMLDSMT 303

Query: 1164 DNLRPTRAEATDVANAVLDGTDGILLGAETLRGQYPVDAVSTVGRICAEAETVYNQSLHF 1343
               RPTRAE +DVA +VLDG D ++L  ET +G+YPV+ V  + RIC E +        F
Sbjct: 304  HGPRPTRAEVSDVAKSVLDGADCVMLSGETAKGKYPVETVVYMSRICCETQVTMWNMAAF 363

Query: 1344 KKVVRHVGEPMAHEEXXXXXXXXXXXXXXXXXIVVFTFSGRAARLVAKYRPPMPVLAVVF 1523
            + +      P+  EE                 I+V T +GR+A +V+KYRPP+P++    
Sbjct: 364  EAIKNLQSFPLIPEEAICSSAVNSIFELHAKAILVLTNTGRSAHMVSKYRPPVPIICA-- 421

Query: 1524 PREGSDPSKWRSYGTTQARQCFSVRGVYPLMGSTDEAETGGLTKEAYGIKLALNYGRSVG 1703
                       S      R     RG  P+   T++       ++  G  LA++ G+ +G
Sbjct: 422  -----------SQELDVCRLLSITRGTIPVYYDTEKLGPDYDREKRVG--LAIDVGKQMG 468

Query: 1704 IIKPYDRVI 1730
            + K  D V+
Sbjct: 469  VFKEGDVVV 477

---

>Q27686:KPYK_LEIME Pyruvate kinase - Leishmania mexicana|
          Length = 499

 Score =  248 bits (634), Expect = 6e-65
 Identities = 151/411 (36%), Positives = 241/411 (58%), Gaps = 4/411 (0%)
 Frame = +3

Query: 297  KIVGTLGPNSHSVEVIEECLTAGMSVARFDFSWKDATYHQETLDNLRKAAQNVKKLCPIM 476
            +I+ T+GP++ SVE ++  + +GMSVAR +FS     YHQ T++N+R+AA  +     I 
Sbjct: 23   RIICTIGPSTQSVEALKGLIQSGMSVARMNFSHGSHEYHQTTINNVRQAAAELGVNIAIA 82

Query: 477  LDTVGPEIQVHNPTGGAIELIGGN--HVTITPDLSKAPSADILPIKFGDLAKVVKKGDTL 650
            LDT GPEI+     GG   +  G   +VT  P  +   + D   I + +L+KVV+ G+ +
Sbjct: 83   LDTKGPEIRTGQFVGGDAVMERGATCYVTTDPAFADKGTKDKFYIDYQNLSKVVRPGNYI 142

Query: 651  FIGQYLFTGSETTSLWLEVMETSGEEVI-CFVKNTATLSGPIFTLHVSQVHISMPTLSEY 827
            +I   +        L L+V     E+ + C V N+ T+S     +++    + +P +S  
Sbjct: 143  YIDDGI--------LILQVQSHEDEQTLECTVTNSHTISDRR-GVNLPGCDVDLPAVSAK 193

Query: 828  DKQVISTWGLDNSVDIISLSHTRSSEDVRELRAFLQSHNLQDTQIYAKIENAEGLEHFDE 1007
            D+ V   +G++  VD+I  S  RS+E V ++R  L     +D  I  KIEN +G+++ D 
Sbjct: 194  DR-VDLQFGVEQGVDMIFASFIRSAEQVGDVRKALGPKG-RDIMIICKIENHQGVQNIDS 251

Query: 1008 ILQEADGIIISRGDLGIDLPPERVFMSQKTGIHKCNMAGKPVI-ITRVVDSMIDNLRPTR 1184
            I++E+DGI+++RGDLG+++P E+V ++QK  I KCN+AGKPVI  T++++SM  N RPTR
Sbjct: 252  IIEESDGIMVARGDLGVEIPAEKVVVAQKILISKCNVAGKPVICATQMLESMTYNPRPTR 311

Query: 1185 AEATDVANAVLDGTDGILLGAETLRGQYPVDAVSTVGRICAEAETVYNQSLHFKKVVRHV 1364
            AE +DVANAV +G D ++L  ET +G+YP + V  + RIC EA++  N+ + F  + +  
Sbjct: 312  AEVSDVANAVFNGADCVMLSGETAKGKYPNEVVQYMARICLEAQSALNEYVFFNSIKKLQ 371

Query: 1365 GEPMAHEEXXXXXXXXXXXXXXXXXIVVFTFSGRAARLVAKYRPPMPVLAV 1517
              PM+ +E                 +VV + +G  ARLVAKYRP  P++ V
Sbjct: 372  HIPMSADEAVCGSAVNSVSETKAKAMVVLSNTGAGARLVAKYRPNCPIVCV 422

---

>P11974:KPYM_RABIT Pyruvate kinase isozymes M1/M2 - Oryctolagus cuniculus (Rabbit)|
          Length = 531

 Score =  248 bits (632), Expect = 1e-64
 Identities = 171/492 (34%), Positives = 264/492 (53%), Gaps = 12/492 (2%)
 Frame = +3

Query: 294  TKIVGTLGPNSHSVEVIEECLTAGMSVARFDFSWKDATYHQETLDNLRKAAQN------V 455
            T I+ T+GP S SVE ++E + +GM+VAR +FS     YH ET+ N+R A ++      +
Sbjct: 45   TGIICTIGPASRSVETLKEMIKSGMNVARMNFSHGTHEYHAETIKNVRTATESFASDPIL 104

Query: 456  KKLCPIMLDTVGPEIQVHNPTGGA---IELIGGNHVTITPDLSKAPSAD--ILPIKFGDL 620
             +   + LDT GPEI+     G     +EL  G  + IT D +     D  IL + + ++
Sbjct: 105  YRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNI 164

Query: 621  AKVVKKGDTLFIGQYLFTGSETTSLWLEVMETSGEEVICFVKNTATLSGPIFTLHVSQVH 800
             KVV  G  +++   L +        L+V +   + ++  V+N   L G    +++    
Sbjct: 165  CKVVDVGSKVYVDDGLIS--------LQVKQKGPDFLVTEVENGGFL-GSKKGVNLPGAA 215

Query: 801  ISMPTLSEYDKQVISTWGLDNSVDIISLSHTRSSEDVRELRAFLQSHNLQDTQIYAKIEN 980
            + +P +SE D Q +  +G++  VD++  S  R + DV E+R  L     ++ +I +KIEN
Sbjct: 216  VDLPAVSEKDIQDLK-FGVEQDVDMVFASFIRKAADVHEVRKILGEKG-KNIKIISKIEN 273

Query: 981  AEGLEHFDEILQEADGIIISRGDLGIDLPPERVFMSQKTGIHKCNMAGKPVI-ITRVVDS 1157
             EG+  FDEIL+ +DGI+++RGDLGI++P E+VF++QK  I +CN AGKPVI  T++++S
Sbjct: 274  HEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMIIGRCNRAGKPVICATQMLES 333

Query: 1158 MIDNLRPTRAEATDVANAVLDGTDGILLGAETLRGQYPVDAVSTVGRICAEAETVYNQSL 1337
            MI   RPTRAE +DVANAVLDG D I+L  ET +G YP++AV     I  EAE       
Sbjct: 334  MIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAMFHRK 393

Query: 1338 HFKKVVRHVGEPMAHEEXXXXXXXXXXXXXXXXXIVVFTFSGRAARLVAKYRPPMPVLAV 1517
             F+++ R         E                 ++V T SGR+A  VA+YRP  P++AV
Sbjct: 394  LFEELARSSSHSTDLMEAMAMGSVEASYKCLAAALIVLTESGRSAHQVARYRPRAPIIAV 453

Query: 1518 VFPREGSDPSKWRSYGTTQARQCFSVRGVYPLMGSTDEAETGGLTKEAYGIKLALNYGRS 1697
                        R++ T  ARQ    RG++P++   D  +          + LA+N G++
Sbjct: 454  T-----------RNHQT--ARQAHLYRGIFPVV-CKDPVQEAWAEDVDLRVNLAMNVGKA 499

Query: 1698 VGIIKPYDRVII 1733
             G  K  D VI+
Sbjct: 500  RGFFKKGDVVIV 511

---

>P14618:KPYM_HUMAN Pyruvate kinase isozymes M1/M2 - Homo sapiens (Human)|
          Length = 531

 Score =  248 bits (632), Expect = 1e-64
 Identities = 170/499 (34%), Positives = 264/499 (52%), Gaps = 12/499 (2%)
 Frame = +3

Query: 273  PKVFPSLTKIVGTLGPNSHSVEVIEECLTAGMSVARFDFSWKDATYHQETLDNLRKAAQN 452
            P +    T I+ T+GP S SVE ++E + +GM+VAR +FS     YH ET+ N+R A ++
Sbjct: 38   PPITARNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATES 97

Query: 453  ------VKKLCPIMLDTVGPEIQVHNPTGGA---IELIGGNHVTITPDLSKAPSAD--IL 599
                  + +   + LDT GPEI+     G     +EL  G  + IT D +     D  IL
Sbjct: 98   FASDPILYRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENIL 157

Query: 600  PIKFGDLAKVVKKGDTLFIGQYLFTGSETTSLWLEVMETSGEEVICFVKNTATLSGPIFT 779
             + + ++ KVV+ G  +++   L +        L+V +   + ++  V+N  +L G    
Sbjct: 158  WLDYKNICKVVEVGSKIYVDDGLIS--------LQVKQKGADFLVTEVENGGSL-GSKKG 208

Query: 780  LHVSQVHISMPTLSEYDKQVISTWGLDNSVDIISLSHTRSSEDVRELRAFLQSHNLQDTQ 959
            +++    + +P +SE D Q +  +G++  VD++  S  R + DV E+R  L     ++ +
Sbjct: 209  VNLPGAAVDLPAVSEKDIQDLK-FGVEQDVDMVFASFIRKASDVHEVRKVLGEKG-KNIK 266

Query: 960  IYAKIENAEGLEHFDEILQEADGIIISRGDLGIDLPPERVFMSQKTGIHKCNMAGKPVI- 1136
            I +KIEN EG+  FDEIL+ +DGI+++RGDLGI++P E+VF++QK  I +CN AGKPVI 
Sbjct: 267  IISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVIC 326

Query: 1137 ITRVVDSMIDNLRPTRAEATDVANAVLDGTDGILLGAETLRGQYPVDAVSTVGRICAEAE 1316
             T++++SMI   RPTRAE +DVANAVLDG D I+L  ET +G YP++AV     I  EAE
Sbjct: 327  ATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAE 386

Query: 1317 TVYNQSLHFKKVVRHVGEPMAHEEXXXXXXXXXXXXXXXXXIVVFTFSGRAARLVAKYRP 1496
                    F+++ R         E                 I+V T SGR+A  VA+YRP
Sbjct: 387  AAIYHLQLFEELRRLAPITSDPTEATAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRP 446

Query: 1497 PMPVLAVVFPREGSDPSKWRSYGTTQARQCFSVRGVYPLMGSTDEAETGGLTKEAYGIKL 1676
              P++AV             +     ARQ    RG++P++   D  +          +  
Sbjct: 447  RAPIIAV-------------TRNPQTARQAHLYRGIFPVL-CKDPVQEAWAEDVDLRVNF 492

Query: 1677 ALNYGRSVGIIKPYDRVII 1733
            A+N G++ G  K  D VI+
Sbjct: 493  AMNVGKARGFFKKGDVVIV 511

---

>Q5NVN0:KPYM_PONPY Pyruvate kinase isozyme M1 - Pongo pygmaeus (Orangutan)|
          Length = 531

 Score =  247 bits (631), Expect = 1e-64
 Identities = 169/499 (33%), Positives = 264/499 (52%), Gaps = 12/499 (2%)
 Frame = +3

Query: 273  PKVFPSLTKIVGTLGPNSHSVEVIEECLTAGMSVARFDFSWKDATYHQETLDNLRKAAQN 452
            P +    T I+ T+GP S SVE ++E + +GM+VAR +FS     YH ET+ N+R A ++
Sbjct: 38   PPITARNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATES 97

Query: 453  ------VKKLCPIMLDTVGPEIQVHNPTGGA---IELIGGNHVTITPDLSKAPSAD--IL 599
                  + +   + LDT GPEI+     G     +EL  G  + IT D +     D  IL
Sbjct: 98   FASDPILYRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENIL 157

Query: 600  PIKFGDLAKVVKKGDTLFIGQYLFTGSETTSLWLEVMETSGEEVICFVKNTATLSGPIFT 779
             + + ++ KVV+ G  +++   L +        L+V +   + ++  V+N  +L G    
Sbjct: 158  WLDYKNICKVVEVGSKIYVDDGLIS--------LQVKQKGADFLLTEVENGGSL-GSKKG 208

Query: 780  LHVSQVHISMPTLSEYDKQVISTWGLDNSVDIISLSHTRSSEDVRELRAFLQSHNLQDTQ 959
            +++    + +P +SE D Q +  +G++  VD++  S  R + DV E+R  L     ++ +
Sbjct: 209  VNLPGAAVDLPAVSEKDIQDLK-FGVEQDVDMVFASFIRKASDVHEVRKVLGEKG-KNIK 266

Query: 960  IYAKIENAEGLEHFDEILQEADGIIISRGDLGIDLPPERVFMSQKTGIHKCNMAGKPVI- 1136
            I +KIEN EG+  FDEIL+ +DGI+++RGDLGI++P E+VF++QK  I +CN AGKPVI 
Sbjct: 267  IISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVIC 326

Query: 1137 ITRVVDSMIDNLRPTRAEATDVANAVLDGTDGILLGAETLRGQYPVDAVSTVGRICAEAE 1316
             T++++SMI   RPTRAE + VANAVLDG D I+L  ET +G YP++AV     I  EAE
Sbjct: 327  ATQMLESMIKKPRPTRAEGSGVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAE 386

Query: 1317 TVYNQSLHFKKVVRHVGEPMAHEEXXXXXXXXXXXXXXXXXIVVFTFSGRAARLVAKYRP 1496
                    F+++VR         E                 ++V T SGR+A  VA+YRP
Sbjct: 387  AAMFHRKLFEELVRASSHSTDLMEAMAMGSVEASYKCLAAALIVLTESGRSAHQVARYRP 446

Query: 1497 PMPVLAVVFPREGSDPSKWRSYGTTQARQCFSVRGVYPLMGSTDEAETGGLTKEAYGIKL 1676
              P++AV             +     ARQ    RG++P++   D  +          +  
Sbjct: 447  RAPIIAV-------------TRNPQTARQAHLYRGIFPVL-CKDPVQEAWAEDVDLRVNF 492

Query: 1677 ALNYGRSVGIIKPYDRVII 1733
            A+N G++ G  K  D VI+
Sbjct: 493  AMNVGKARGFFKKGDVVIV 511

---

>P52480:KPYM_MOUSE Pyruvate kinase isozymes M1/M2 - Mus musculus (Mouse)|
          Length = 531

 Score =  247 bits (630), Expect = 2e-64
 Identities = 170/492 (34%), Positives = 264/492 (53%), Gaps = 12/492 (2%)
 Frame = +3

Query: 294  TKIVGTLGPNSHSVEVIEECLTAGMSVARFDFSWKDATYHQETLDNLRKAAQN------V 455
            T I+ T+GP S SVE+++E + +GM+VAR +FS     YH ET+ N+R+A ++      +
Sbjct: 45   TGIICTIGPASRSVEMLKEMIKSGMNVARLNFSHGTHEYHAETIKNVREATESFASDPIL 104

Query: 456  KKLCPIMLDTVGPEIQVHNPTGGA---IELIGGNHVTITPDLSKAPSAD--ILPIKFGDL 620
             +   + LDT GPEI+     G     +EL  G  + IT D +     D  IL + + ++
Sbjct: 105  YRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNI 164

Query: 621  AKVVKKGDTLFIGQYLFTGSETTSLWLEVMETSGEEVICFVKNTATLSGPIFTLHVSQVH 800
             KVV+ G  +++   L +        L+V E   + ++  V+N  +L G    +++    
Sbjct: 165  CKVVEVGSKIYVDDGLIS--------LQVKEKGADFLVTEVENGGSL-GSKKGVNLPGAA 215

Query: 801  ISMPTLSEYDKQVISTWGLDNSVDIISLSHTRSSEDVRELRAFLQSHNLQDTQIYAKIEN 980
            + +P +SE D Q +  +G++  VD++  S  R + DV E+R  L     ++ +I +KIEN
Sbjct: 216  VDLPAVSEKDIQDLK-FGVEQDVDMVFASFIRKAADVHEVRKVLGEKG-KNIKIISKIEN 273

Query: 981  AEGLEHFDEILQEADGIIISRGDLGIDLPPERVFMSQKTGIHKCNMAGKPVI-ITRVVDS 1157
             EG+  FDEIL+ +DGI+++RGDLGI++P E+VF++QK  I +CN AGKPVI  T++++S
Sbjct: 274  HEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLES 333

Query: 1158 MIDNLRPTRAEATDVANAVLDGTDGILLGAETLRGQYPVDAVSTVGRICAEAETVYNQSL 1337
            MI   RPTRAE +DVANAVLDG D I+L  ET +G YP++AV     I  EAE       
Sbjct: 334  MIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQ 393

Query: 1338 HFKKVVRHVGEPMAHEEXXXXXXXXXXXXXXXXXIVVFTFSGRAARLVAKYRPPMPVLAV 1517
             F+++ R         E                 I+V T SGR+A  VA+YRP  P++AV
Sbjct: 394  LFEELRRLAPITSDPTEAAAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAV 453

Query: 1518 VFPREGSDPSKWRSYGTTQARQCFSVRGVYPLMGSTDEAETGGLTKEAYGIKLALNYGRS 1697
                         +     ARQ    RG++P++   D             + LA++ G++
Sbjct: 454  -------------TRNPQTARQAHLYRGIFPVL-CKDAVLNAWAEDVDLRVNLAMDVGKA 499

Query: 1698 VGIIKPYDRVII 1733
             G  K  D VI+
Sbjct: 500  RGFFKKGDVVIV 511

---

>O62619:KPYK_DROME Pyruvate kinase - Drosophila melanogaster (Fruit fly)|
          Length = 533

 Score =  247 bits (630), Expect = 2e-64
 Identities = 175/495 (35%), Positives = 273/495 (55%), Gaps = 14/495 (2%)
 Frame = +3

Query: 291  LTKIVGTLGPNSHSVEVIEECLTAGMSVARFDFSWKDATYHQETLDNLRKAAQNVK-KL- 464
            L+ IV T+GP S SVE++E+ +  GM++AR +FS     YH  T+ N+R+A +N   KL 
Sbjct: 47   LSGIVCTIGPASSSVEMLEKMMATGMNIARMNFSHGSHEYHAATVANVRQAVKNYSAKLG 106

Query: 465  ----CPIMLDTVGPEIQVHNPTGGA---IELIGGNHVTITP--DLSKAPSADILPIKFGD 617
                  I LDT GPEI+     G     IEL  G  + +T   +  +  S +I+ + + +
Sbjct: 107  YEHPVAIALDTKGPEIRTGLIGGSGTAEIELKKGEKIKLTTNKEFLEKGSLEIVYVDYEN 166

Query: 618  LAKVVKKGDTLFIGQYLFTGSETTSLWLEVMETSGEEVICFVKNTATLSGPIFTLHVSQV 797
            +  VVK G+ +F+   L +        L V E   + + C V+N  +L G    +++  V
Sbjct: 167  IVNVVKPGNRVFVDDGLIS--------LIVREVGKDSLTCEVENGGSL-GSRKGVNLPGV 217

Query: 798  HISMPTLSEYDKQVISTWGLDNSVDIISLSHTRSSEDVRELRAFLQSHNLQDTQIYAKIE 977
             + +P +SE DK  +  +G++  VD+I  S  R++  + E+R  L     ++ +I +KIE
Sbjct: 218  PVDLPAVSEKDKSDL-LFGVEQEVDMIFASFIRNAAALTEIRKVLGEKG-KNIKIISKIE 275

Query: 978  NAEGLEHFDEILQEADGIIISRGDLGIDLPPERVFMSQKTGIHKCNMAGKPVI-ITRVVD 1154
            N +G+ + DEI++  DGI+++RGDLGI++P E+VF++QK  I +CN AGKPVI  T++++
Sbjct: 276  NQQGMHNLDEIIEAGDGIMVARGDLGIEIPAEKVFLAQKAMIARCNKAGKPVICATQMLE 335

Query: 1155 SMIDNLRPTRAEATDVANAVLDGTDGILLGAETLRGQYPVDAVSTVGRICAEAE-TVYNQ 1331
            SM+   RPTRAE +DVANAVLDG D ++L  ET +G+YP++ V T+ + C EAE  +++Q
Sbjct: 336  SMVKKPRPTRAEISDVANAVLDGADCVMLSGETAKGEYPLECVLTMAKTCKEAEAALWHQ 395

Query: 1332 SLHFKKVVRHVGEPMAHEEXXXXXXXXXXXXXXXXXIVVFTFSGRAARLVAKYRPPMPVL 1511
            +L F  +VR  G   A                    IVV T SG++A  V+KYRP  P++
Sbjct: 396  NL-FNDLVRGAGTIDA-SHAAAIAAVEAATKAKASAIVVITTSGKSAFQVSKYRPRCPII 453

Query: 1512 AVVFPREGSDPSKWRSYGTTQARQCFSVRGVYPLMGSTDEAETGGLTKEA-YGIKLALNY 1688
            AV              +  T ARQ    RG+ PL+    E   G   K+    ++  L  
Sbjct: 454  AVT------------RFAQT-ARQAHLYRGLVPLI--YKEPGLGDWLKDVDVRVQFGLQV 498

Query: 1689 GRSVGIIKPYDRVII 1733
            G+  G IK  D V++
Sbjct: 499  GKKNGFIKTGDSVVV 513

---

>Q12669:KPYK_ASPNG Pyruvate kinase - Aspergillus niger|
          Length = 526

 Score =  247 bits (630), Expect = 2e-64
 Identities = 172/537 (32%), Positives = 276/537 (51%), Gaps = 13/537 (2%)
 Frame = +3

Query: 216  NHMLLEEPVRLASVLAPAKPKVFPSLTKIVGTLGPNSHSVEVIEECLTAGMSVARFDFSW 395
            N M LE   +L + + P+K       T I+GT+GP ++SVE I    TAG++V R +FS 
Sbjct: 12   NRMKLEWHSKLNTEMVPSKNF---RRTSIIGTIGPKTNSVEKINSLRTAGLNVVRMNFSH 68

Query: 396  KDATYHQETLDNLRKAAQN-VKKLCPIMLDTVGPEIQVHN-PTGGAIELIGGNHVTITPD 569
                YHQ  +DN R+AA+  V +   I LDT GPEI+  N P    I +  G+ + IT D
Sbjct: 69   GSYQYHQSVIDNAREAAKTQVGRPLAIALDTKGPEIRTGNTPDDKDIPIKQGHELNITTD 128

Query: 570  LSKAPSADI--LPIKFGDLAKVVKKGDTLFIGQYLFTGSETTSLWLEVMETSGEEVICFV 743
               A ++D   + + + ++ KV+  G  +++   + +        LEV++     V C  
Sbjct: 129  EQYATASDDKNMYLDYKNITKVISPGKLIYVDDGILSFEV-----LEVVDDKTIRVRCLN 183

Query: 744  K-NTATLSGPIFTLHVSQVHISMPTLSEYDKQVISTWGLDNSVDIISLSHTRSSEDVREL 920
              N ++  G    +++    + +P LSE D   +  +G+ N VD++  S  R   D+R +
Sbjct: 184  NGNISSRKG----VNLPGTDVDLPALSEKDIADLK-FGVRNKVDMVFASFIRRGSDIRHI 238

Query: 921  RAFLQSHNLQDTQIYAKIENAEGLEHFDEILQEADGIIISRGDLGIDLPPERVFMSQKTG 1100
            R  L     ++ QI AKIEN +G+ +FDEIL+E DG++++RGDLGI++P  +VF++QK  
Sbjct: 239  REVLGEEG-KEIQIIAKIENQQGVNNFDEILEETDGVMVARGDLGIEIPAPKVFIAQKMM 297

Query: 1101 IHKCNMAGKPVI-ITRVVDSMIDNLRPTRAEATDVANAVLDGTDGILLGAETLRGQYPVD 1277
            I KCN+ GKPVI  T++++SM  N RPTRAE +DVANAVLDG D ++L  ET +G YP +
Sbjct: 298  IAKCNIKGKPVICATQMLESMTYNPRPTRAEVSDVANAVLDGADCVMLSGETAKGNYPNE 357

Query: 1278 AVSTVGRICAEAETVYNQSLHFKKVVRHVGEPMAHEEXXXXXXXXXXXXXXXXXIVVFTF 1457
            AV  +   C  AE        F ++      P    E                 IVV T 
Sbjct: 358  AVKMMSETCLLAEVAIPHFNVFDELRNLAPRPTDTVESIAMAAVSASLELNAGAIVVLTT 417

Query: 1458 SGRAARLVAKYRPPMPVLAVVFPREGSDPSKWRSYGTTQARQCFSVRGVYPLMGSTDEAE 1637
            SG+ AR ++KYRP  P++ V             +     +R     RGV+P +    + +
Sbjct: 418  SGKTARYLSKYRPVCPIVMV-------------TRNPAASRYSHLYRGVWPFLFPEKKPD 464

Query: 1638 TGGLTKEA---YGIKLALNYGRSVGIIKPYDRVIIFE----KIGDSSVVKIIECDDS 1787
                  +      +K  +N+   +GII   D ++  +     +G ++ V+++  +++
Sbjct: 465  FNVKVWQEDVDRRLKWGINHALKLGIINKGDNIVCVQGWRGGMGHTNTVRVVPAEEN 521

---

>Q6GG09:KPYK_STAAR Pyruvate kinase - Staphylococcus aureus (strain MRSA252)|
          Length = 585

 Score =  246 bits (628), Expect = 3e-64
 Identities = 161/450 (35%), Positives = 249/450 (55%), Gaps = 9/450 (2%)
 Frame = +3

Query: 294  TKIVGTLGPNSHSVEVIEECLTAGMSVARFDFSWKDATYHQETLDNLRKAAQNVKKLCPI 473
            TKIV T+GP S S E+IE+ + AGM+VAR +FS      H+  +D +RK A+ + K+  I
Sbjct: 4    TKIVCTIGPASESEEMIEKLINAGMNVARLNFSHGSHEEHKGRIDTIRKVAKRLDKIVAI 63

Query: 474  MLDTVGPEIQVHNPTGGAIELIGGNHVTITPDLSKAPSADILPIKFGDLAKVVKKGDTLF 653
            +LDT GPEI+ HN   G IEL  GN V ++ +  +  + +   + + +L   V+      
Sbjct: 64   LLDTKGPEIRTHNMKDGIIELERGNEVIVSMNEVEG-TPEKFSVTYENLINDVQ------ 116

Query: 654  IGQYLFTGSETTSLWLEVMETSGEEVICFVKNTATLSGPIFTLHVSQVHISMPTLSEYDK 833
            +G Y+        L ++ ++ + +EV C + N+  L      +++  V +S+P ++E D 
Sbjct: 117  VGSYILLDDGLIELQVKDIDHAKKEVKCDILNSGELKNK-KGVNLPGVRVSLPGITEKDA 175

Query: 834  QVISTWGLDNSVDIISLSHTRSSEDVRELRAFLQSHNLQDTQIYAKIENAEGLEHFDEIL 1013
            + I  +G+  +VD I+ S  R   DV E+R  L+     +  ++ KIEN EG+++ +EIL
Sbjct: 176  EDI-RFGIKENVDFIAASFVRRPSDVLEIREILEEQK-ANISVFPKIENQEGIDNIEEIL 233

Query: 1014 QEADGIIISRGDLGIDLPPERVFMSQKTGIHKCNMAGKPVI-ITRVVDSMIDNLRPTRAE 1190
            + +DG++++RGD+G+++PPE+V M QK  I +CN  GKPVI  T+++DSM  N R TRAE
Sbjct: 234  EVSDGLMVARGDMGVEIPPEKVPMVQKDLIRQCNKLGKPVITATQMLDSMQRNPRATRAE 293

Query: 1191 ATDVANAVLDGTDGILLGAETLRGQYPVDAVSTVGRICAEAETV--YNQSLHFK------ 1346
            A+DVANA+ DGTD ++L  ET  G YP +AV T+  I   AE    Y + L  +      
Sbjct: 294  ASDVANAIYDGTDAVMLSGETAAGLYPEEAVKTMRNIAVSAEAAQDYKKLLSDRTKLVET 353

Query: 1347 KVVRHVGEPMAHEEXXXXXXXXXXXXXXXXXIVVFTFSGRAARLVAKYRPPMPVLAVVFP 1526
             +V  +G  +AH                   IV  T SG  AR ++KYRP   ++AV   
Sbjct: 354  SLVNAIGISVAH----------TALNLNVKAIVAATESGSTARTISKYRPHSDIIAVT-- 401

Query: 1527 REGSDPSKWRSYGTTQARQCFSVRGVYPLM 1616
                 PS+        ARQC  V GV P++
Sbjct: 402  -----PSE------ETARQCSIVWGVQPVV 420

---

>O08309:KPYK_CLOAB Pyruvate kinase - Clostridium acetobutylicum|
          Length = 473

 Score =  245 bits (625), Expect = 6e-64
 Identities = 163/451 (36%), Positives = 242/451 (53%), Gaps = 5/451 (1%)
 Frame = +3

Query: 294  TKIVGTLGPNSHSVEVIEECLTAGMSVARFDFSWKDATYHQETLDNLRKAAQNVKKLCPI 473
            TK++ T+GP S + E++   + AGM+ +R +FS  D   H   +  ++K    + K   I
Sbjct: 4    TKMIFTVGPASETEEIVTAFIKAGMNASRHNFSHGDHAEHGGRIALVKKVRAKLNKPVAI 63

Query: 474  MLDTVGPEIQVHNPTGGAIELIGGNHVTITPDLSKAPSADILPIKFGDLAKVVKKGDTLF 653
             LDT GPEI+  +     +EL  G+  TI         A    I + DL K VK G+T+ 
Sbjct: 64   CLDTKGPEIRTGDFNPSKLELQKGSKFTIVCGEEIVGDATKCSISYKDLYKDVKPGNTIL 123

Query: 654  IGQYLFTGSETTSLWLEVMETSGEEVICFVKNTATLSGPIFTLHVSQVHISMPTLSEYDK 833
            I   L        L +E +E  G  VIC V NT  L G    ++V  V I +P ++E DK
Sbjct: 124  IDDGL------VGLTVEAIE--GTNVICTVANTG-LVGSHKGVNVPNVSIQLPAMTEKDK 174

Query: 834  QVISTWGLDNSVDIISLSHTRSSEDVRELRAFLQSHNLQDTQIYAKIENAEGLEHFDEIL 1013
              +  +G    +D++S S  R  EDV  +R  L  +  ++ QI++KIEN EG+++ D I+
Sbjct: 175  SDL-IFGCKEEIDMVSASFIRKPEDVLAIRKVLNENGGENIQIFSKIENQEGVDNIDAII 233

Query: 1014 QEADGIIISRGDLGIDLPPERVFMSQKTGIHKCNMAGKPVI-ITRVVDSMIDNLRPTRAE 1190
            + +DGI+++RGD+G+++P +RV + QK  I KCN  GKPVI  T+++DSM+ N RPTRAE
Sbjct: 234  EVSDGIMVARGDMGVEIPIQRVPLIQKMIIKKCNAVGKPVITATQMLDSMMRNPRPTRAE 293

Query: 1191 ATDVANAVLDGTDGILLGAETLRGQYPVDAVSTVGRICAEAETVYNQSLHFKKVVRHVGE 1370
            A+D+ANA+ DGTD I+L  E+  G YP++AV+T+ +I  EAE   N      +  R   E
Sbjct: 294  ASDIANAIFDGTDAIMLSGESANGSYPIEAVTTMAKIAQEAENEINYDKFLAE--RKGNE 351

Query: 1371 PMAHEEXXXXXXXXXXXXXXXXXIVVFTFSGRAARLVAKYRPPMPVLAVVFPREGSDPSK 1550
                 +                 I+  T +G  AR V+KYRP  PV+AV        PS+
Sbjct: 352  KKNTSDVISLGTCTAAADLEASAIITATQTGSTARTVSKYRPKAPVIAVT-------PSE 404

Query: 1551 WRSYGTTQARQCFSVRGVYPLM----GSTDE 1631
                    AR+     GV+P++    GSTDE
Sbjct: 405  ------KVARKLAMSWGVHPIISDKFGSTDE 429

---

>Q7A0N4:KPYK_STAAW Pyruvate kinase - Staphylococcus aureus (strain MW2)|
          Length = 585

 Score =  244 bits (624), Expect = 8e-64
 Identities = 161/450 (35%), Positives = 248/450 (55%), Gaps = 9/450 (2%)
 Frame = +3

Query: 294  TKIVGTLGPNSHSVEVIEECLTAGMSVARFDFSWKDATYHQETLDNLRKAAQNVKKLCPI 473
            TKIV T+GP S S E+IE+ + AGM+VAR +FS      H+  +D +RK A+ + K+  I
Sbjct: 4    TKIVCTIGPASESEEMIEKLINAGMNVARLNFSHGSHEEHKGRIDTIRKVAKRLDKIVAI 63

Query: 474  MLDTVGPEIQVHNPTGGAIELIGGNHVTITPDLSKAPSADILPIKFGDLAKVVKKGDTLF 653
            +LDT GPEI+ HN   G IEL  GN V ++ +  +  + +   + + +L   V+      
Sbjct: 64   LLDTKGPEIRTHNMKDGIIELERGNEVIVSMNEVEG-TPEKFSVTYENLINDVQ------ 116

Query: 654  IGQYLFTGSETTSLWLEVMETSGEEVICFVKNTATLSGPIFTLHVSQVHISMPTLSEYDK 833
            +G Y+        L ++ ++ + +EV C + N+  L      +++  V +S+P ++E D 
Sbjct: 117  VGSYILLDDGLIELQVKDIDHAKKEVKCDILNSGELKNK-KGVNLPGVRVSLPGITEKDA 175

Query: 834  QVISTWGLDNSVDIISLSHTRSSEDVRELRAFLQSHNLQDTQIYAKIENAEGLEHFDEIL 1013
            + I  +G+  +VD I+ S  R   DV E+R  L+     +  ++ KIEN EG+++  EIL
Sbjct: 176  EDI-RFGIKENVDFIAASFVRRPSDVLEIREILEEQK-ANISVFPKIENQEGIDNIAEIL 233

Query: 1014 QEADGIIISRGDLGIDLPPERVFMSQKTGIHKCNMAGKPVI-ITRVVDSMIDNLRPTRAE 1190
            + +DG++++RGD+G+++PPE+V M QK  I +CN  GKPVI  T+++DSM  N R TRAE
Sbjct: 234  EVSDGLMVARGDMGVEIPPEKVPMVQKDLIRQCNKLGKPVITATQMLDSMQRNPRATRAE 293

Query: 1191 ATDVANAVLDGTDGILLGAETLRGQYPVDAVSTVGRICAEAETV--YNQSLHFK------ 1346
            A+DVANA+ DGTD ++L  ET  G YP +AV T+  I   AE    Y + L  +      
Sbjct: 294  ASDVANAIYDGTDAVMLSGETAAGLYPEEAVKTMRNIAVSAEAAQDYKKLLSDRTKLVET 353

Query: 1347 KVVRHVGEPMAHEEXXXXXXXXXXXXXXXXXIVVFTFSGRAARLVAKYRPPMPVLAVVFP 1526
             +V  +G  +AH                   IV  T SG  AR ++KYRP   ++AV   
Sbjct: 354  SLVNAIGISVAH----------TALNLNVKAIVAATESGSTARTISKYRPHSDIIAVT-- 401

Query: 1527 REGSDPSKWRSYGTTQARQCFSVRGVYPLM 1616
                 PS+        ARQC  V GV P++
Sbjct: 402  -----PSE------ETARQCSIVWGVQPVV 420

---

>Q6G8M9:KPYK_STAAS Pyruvate kinase - Staphylococcus aureus (strain MSSA476)|
          Length = 585

 Score =  244 bits (624), Expect = 8e-64
 Identities = 161/450 (35%), Positives = 248/450 (55%), Gaps = 9/450 (2%)
 Frame = +3

Query: 294  TKIVGTLGPNSHSVEVIEECLTAGMSVARFDFSWKDATYHQETLDNLRKAAQNVKKLCPI 473
            TKIV T+GP S S E+IE+ + AGM+VAR +FS      H+  +D +RK A+ + K+  I
Sbjct: 4    TKIVCTIGPASESEEMIEKLINAGMNVARLNFSHGSHEEHKGRIDTIRKVAKRLDKIVAI 63

Query: 474  MLDTVGPEIQVHNPTGGAIELIGGNHVTITPDLSKAPSADILPIKFGDLAKVVKKGDTLF 653
            +LDT GPEI+ HN   G IEL  GN V ++ +  +  + +   + + +L   V+      
Sbjct: 64   LLDTKGPEIRTHNMKDGIIELERGNEVIVSMNEVEG-TPEKFSVTYENLINDVQ------ 116

Query: 654  IGQYLFTGSETTSLWLEVMETSGEEVICFVKNTATLSGPIFTLHVSQVHISMPTLSEYDK 833
            +G Y+        L ++ ++ + +EV C + N+  L      +++  V +S+P ++E D 
Sbjct: 117  VGSYILLDDGLIELQVKDIDHAKKEVKCDILNSGELKNK-KGVNLPGVRVSLPGITEKDA 175

Query: 834  QVISTWGLDNSVDIISLSHTRSSEDVRELRAFLQSHNLQDTQIYAKIENAEGLEHFDEIL 1013
            + I  +G+  +VD I+ S  R   DV E+R  L+     +  ++ KIEN EG+++  EIL
Sbjct: 176  EDI-RFGIKENVDFIAASFVRRPSDVLEIREILEEQK-ANISVFPKIENQEGIDNIAEIL 233

Query: 1014 QEADGIIISRGDLGIDLPPERVFMSQKTGIHKCNMAGKPVI-ITRVVDSMIDNLRPTRAE 1190
            + +DG++++RGD+G+++PPE+V M QK  I +CN  GKPVI  T+++DSM  N R TRAE
Sbjct: 234  EVSDGLMVARGDMGVEIPPEKVPMVQKDLIRQCNKLGKPVITATQMLDSMQRNPRATRAE 293

Query: 1191 ATDVANAVLDGTDGILLGAETLRGQYPVDAVSTVGRICAEAETV--YNQSLHFK------ 1346
            A+DVANA+ DGTD ++L  ET  G YP +AV T+  I   AE    Y + L  +      
Sbjct: 294  ASDVANAIYDGTDAVMLSGETAAGLYPEEAVKTMRNIAVSAEAAQDYKKLLSDRTKLVET 353

Query: 1347 KVVRHVGEPMAHEEXXXXXXXXXXXXXXXXXIVVFTFSGRAARLVAKYRPPMPVLAVVFP 1526
             +V  +G  +AH                   IV  T SG  AR ++KYRP   ++AV   
Sbjct: 354  SLVNAIGISVAH----------TALNLNVKAIVAATESGSTARTISKYRPHSDIIAVT-- 401

Query: 1527 REGSDPSKWRSYGTTQARQCFSVRGVYPLM 1616
                 PS+        ARQC  V GV P++
Sbjct: 402  -----PSE------ETARQCSIVWGVQPVV 420

---

>Q7A559:KPYK_STAAN Pyruvate kinase - Staphylococcus aureus (strain N315)|
          Length = 585

 Score =  244 bits (624), Expect = 8e-64
 Identities = 161/450 (35%), Positives = 248/450 (55%), Gaps = 9/450 (2%)
 Frame = +3

Query: 294  TKIVGTLGPNSHSVEVIEECLTAGMSVARFDFSWKDATYHQETLDNLRKAAQNVKKLCPI 473
            TKIV T+GP S S E+IE+ + AGM+VAR +FS      H+  +D +RK A+ + K+  I
Sbjct: 4    TKIVCTIGPASESEEMIEKLINAGMNVARLNFSHGSHEEHKGRIDTIRKVAKRLDKIVAI 63

Query: 474  MLDTVGPEIQVHNPTGGAIELIGGNHVTITPDLSKAPSADILPIKFGDLAKVVKKGDTLF 653
            +LDT GPEI+ HN   G IEL  GN V ++ +  +  + +   + + +L   V+      
Sbjct: 64   LLDTKGPEIRTHNMKDGIIELERGNEVIVSMNEVEG-TPEKFSVTYENLINDVQ------ 116

Query: 654  IGQYLFTGSETTSLWLEVMETSGEEVICFVKNTATLSGPIFTLHVSQVHISMPTLSEYDK 833
            +G Y+        L ++ ++ + +EV C + N+  L      +++  V +S+P ++E D 
Sbjct: 117  VGSYILLDDGLIELQVKDIDHAKKEVKCDILNSGELKNK-KGVNLPGVRVSLPGITEKDA 175

Query: 834  QVISTWGLDNSVDIISLSHTRSSEDVRELRAFLQSHNLQDTQIYAKIENAEGLEHFDEIL 1013
            + I  +G+  +VD I+ S  R   DV E+R  L+     +  ++ KIEN EG+++  EIL
Sbjct: 176  EDI-RFGIKENVDFIAASFVRRPSDVLEIREILEEQK-ANISVFPKIENQEGIDNIAEIL 233

Query: 1014 QEADGIIISRGDLGIDLPPERVFMSQKTGIHKCNMAGKPVI-ITRVVDSMIDNLRPTRAE 1190
            + +DG++++RGD+G+++PPE+V M QK  I +CN  GKPVI  T+++DSM  N R TRAE
Sbjct: 234  EVSDGLMVARGDMGVEIPPEKVPMVQKDLIRQCNKLGKPVITATQMLDSMQRNPRATRAE 293

Query: 1191 ATDVANAVLDGTDGILLGAETLRGQYPVDAVSTVGRICAEAETV--YNQSLHFK------ 1346
            A+DVANA+ DGTD ++L  ET  G YP +AV T+  I   AE    Y + L  +      
Sbjct: 294  ASDVANAIYDGTDAVMLSGETAAGLYPEEAVKTMRNIAVSAEAAQDYKKLLSDRTKLVET 353

Query: 1347 KVVRHVGEPMAHEEXXXXXXXXXXXXXXXXXIVVFTFSGRAARLVAKYRPPMPVLAVVFP 1526
             +V  +G  +AH                   IV  T SG  AR ++KYRP   ++AV   
Sbjct: 354  SLVNAIGISVAH----------TALNLNVKAIVAATESGSTARTISKYRPHSDIIAVT-- 401

Query: 1527 REGSDPSKWRSYGTTQARQCFSVRGVYPLM 1616
                 PS+        ARQC  V GV P++
Sbjct: 402  -----PSE------ETARQCSIVWGVQPVV 420

---

>Q99TG5:KPYK_STAAM Pyruvate kinase - Staphylococcus aureus (strain Mu50 / ATCC 700699)|
          Length = 585

 Score =  244 bits (624), Expect = 8e-64
 Identities = 161/450 (35%), Positives = 248/450 (55%), Gaps = 9/450 (2%)
 Frame = +3

Query: 294  TKIVGTLGPNSHSVEVIEECLTAGMSVARFDFSWKDATYHQETLDNLRKAAQNVKKLCPI 473
            TKIV T+GP S S E+IE+ + AGM+VAR +FS      H+  +D +RK A+ + K+  I
Sbjct: 4    TKIVCTIGPASESEEMIEKLINAGMNVARLNFSHGSHEEHKGRIDTIRKVAKRLDKIVAI 63

Query: 474  MLDTVGPEIQVHNPTGGAIELIGGNHVTITPDLSKAPSADILPIKFGDLAKVVKKGDTLF 653
            +LDT GPEI+ HN   G IEL  GN V ++ +  +  + +   + + +L   V+      
Sbjct: 64   LLDTKGPEIRTHNMKDGIIELERGNEVIVSMNEVEG-TPEKFSVTYENLINDVQ------ 116

Query: 654  IGQYLFTGSETTSLWLEVMETSGEEVICFVKNTATLSGPIFTLHVSQVHISMPTLSEYDK 833
            +G Y+        L ++ ++ + +EV C + N+  L      +++  V +S+P ++E D 
Sbjct: 117  VGSYILLDDGLIELQVKDIDHAKKEVKCDILNSGELKNK-KGVNLPGVRVSLPGITEKDA 175

Query: 834  QVISTWGLDNSVDIISLSHTRSSEDVRELRAFLQSHNLQDTQIYAKIENAEGLEHFDEIL 1013
            + I  +G+  +VD I+ S  R   DV E+R  L+     +  ++ KIEN EG+++  EIL
Sbjct: 176  EDI-RFGIKENVDFIAASFVRRPSDVLEIREILEEQK-ANISVFPKIENQEGIDNIAEIL 233

Query: 1014 QEADGIIISRGDLGIDLPPERVFMSQKTGIHKCNMAGKPVI-ITRVVDSMIDNLRPTRAE 1190
            + +DG++++RGD+G+++PPE+V M QK  I +CN  GKPVI  T+++DSM  N R TRAE
Sbjct: 234  EVSDGLMVARGDMGVEIPPEKVPMVQKDLIRQCNKLGKPVITATQMLDSMQRNPRATRAE 293

Query: 1191 ATDVANAVLDGTDGILLGAETLRGQYPVDAVSTVGRICAEAETV--YNQSLHFK------ 1346
            A+DVANA+ DGTD ++L  ET  G YP +AV T+  I   AE    Y + L  +      
Sbjct: 294  ASDVANAIYDGTDAVMLSGETAAGLYPEEAVKTMRNIAVSAEAAQDYKKLLSDRTKLVET 353

Query: 1347 KVVRHVGEPMAHEEXXXXXXXXXXXXXXXXXIVVFTFSGRAARLVAKYRPPMPVLAVVFP 1526
             +V  +G  +AH                   IV  T SG  AR ++KYRP   ++AV   
Sbjct: 354  SLVNAIGISVAH----------TALNLNVKAIVAATESGSTARTISKYRPHSDIIAVT-- 401

Query: 1527 REGSDPSKWRSYGTTQARQCFSVRGVYPLM 1616
                 PS+        ARQC  V GV P++
Sbjct: 402  -----PSE------ETARQCSIVWGVQPVV 420

---

>Q5HF76:KPYK_STAAC Pyruvate kinase - Staphylococcus aureus (strain COL)|
          Length = 585

 Score =  244 bits (624), Expect = 8e-64
 Identities = 161/450 (35%), Positives = 248/450 (55%), Gaps = 9/450 (2%)
 Frame = +3

Query: 294  TKIVGTLGPNSHSVEVIEECLTAGMSVARFDFSWKDATYHQETLDNLRKAAQNVKKLCPI 473
            TKIV T+GP S S E+IE+ + AGM+VAR +FS      H+  +D +RK A+ + K+  I
Sbjct: 4    TKIVCTIGPASESEEMIEKLINAGMNVARLNFSHGSHEEHKGRIDTIRKVAKRLDKIVAI 63

Query: 474  MLDTVGPEIQVHNPTGGAIELIGGNHVTITPDLSKAPSADILPIKFGDLAKVVKKGDTLF 653
            +LDT GPEI+ HN   G IEL  GN V ++ +  +  + +   + + +L   V+      
Sbjct: 64   LLDTKGPEIRTHNMKDGIIELERGNEVIVSMNEVEG-TPEKFSVTYENLINDVQ------ 116

Query: 654  IGQYLFTGSETTSLWLEVMETSGEEVICFVKNTATLSGPIFTLHVSQVHISMPTLSEYDK 833
            +G Y+        L ++ ++ + +EV C + N+  L      +++  V +S+P ++E D 
Sbjct: 117  VGSYILLDDGLIELQVKDIDHAKKEVKCDILNSGELKNK-KGVNLPGVRVSLPGITEKDA 175

Query: 834  QVISTWGLDNSVDIISLSHTRSSEDVRELRAFLQSHNLQDTQIYAKIENAEGLEHFDEIL 1013
            + I  +G+  +VD I+ S  R   DV E+R  L+     +  ++ KIEN EG+++  EIL
Sbjct: 176  EDI-RFGIKENVDFIAASFVRRPSDVLEIREILEEQK-ANISVFPKIENQEGIDNIAEIL 233

Query: 1014 QEADGIIISRGDLGIDLPPERVFMSQKTGIHKCNMAGKPVI-ITRVVDSMIDNLRPTRAE 1190
            + +DG++++RGD+G+++PPE+V M QK  I +CN  GKPVI  T+++DSM  N R TRAE
Sbjct: 234  EVSDGLMVARGDMGVEIPPEKVPMVQKDLIRQCNKLGKPVITATQMLDSMQRNPRATRAE 293

Query: 1191 ATDVANAVLDGTDGILLGAETLRGQYPVDAVSTVGRICAEAETV--YNQSLHFK------ 1346
            A+DVANA+ DGTD ++L  ET  G YP +AV T+  I   AE    Y + L  +      
Sbjct: 294  ASDVANAIYDGTDAVMLSGETAAGLYPEEAVKTMRNIAVSAEAAQDYKKLLSDRTKLVET 353

Query: 1347 KVVRHVGEPMAHEEXXXXXXXXXXXXXXXXXIVVFTFSGRAARLVAKYRPPMPVLAVVFP 1526
             +V  +G  +AH                   IV  T SG  AR ++KYRP   ++AV   
Sbjct: 354  SLVNAIGISVAH----------TALNLNVKAIVAATESGSTARTISKYRPHSDIIAVT-- 401

Query: 1527 REGSDPSKWRSYGTTQARQCFSVRGVYPLM 1616
                 PS+        ARQC  V GV P++
Sbjct: 402  -----PSE------ETARQCSIVWGVQPVV 420

---

>Q2YTE3:KPYK_STAAB Pyruvate kinase - Staphylococcus aureus (strain bovine RF122)|
          Length = 585

 Score =  244 bits (624), Expect = 8e-64
 Identities = 161/450 (35%), Positives = 248/450 (55%), Gaps = 9/450 (2%)
 Frame = +3

Query: 294  TKIVGTLGPNSHSVEVIEECLTAGMSVARFDFSWKDATYHQETLDNLRKAAQNVKKLCPI 473
            TKIV T+GP S S E+IE+ + AGM+VAR +FS      H+  +D +RK A+ + K+  I
Sbjct: 4    TKIVCTIGPASESEEMIEKLINAGMNVARLNFSHGSHEEHKGRIDTIRKVAKRLDKIVAI 63

Query: 474  MLDTVGPEIQVHNPTGGAIELIGGNHVTITPDLSKAPSADILPIKFGDLAKVVKKGDTLF 653
            +LDT GPEI+ HN   G IEL  GN V ++ +  +  + +   + + +L   V+      
Sbjct: 64   LLDTKGPEIRTHNMKDGIIELERGNEVIVSMNEVEG-TPEKFSVTYENLINDVQ------ 116

Query: 654  IGQYLFTGSETTSLWLEVMETSGEEVICFVKNTATLSGPIFTLHVSQVHISMPTLSEYDK 833
            +G Y+        L ++ ++ + +EV C + N+  L      +++  V +S+P ++E D 
Sbjct: 117  VGSYILLDDGLIELQVKDIDHAKKEVKCDILNSGELKNK-KGVNLPGVRVSLPGITEKDA 175

Query: 834  QVISTWGLDNSVDIISLSHTRSSEDVRELRAFLQSHNLQDTQIYAKIENAEGLEHFDEIL 1013
            + I  +G+  +VD I+ S  R   DV E+R  L+     +  ++ KIEN EG+++  EIL
Sbjct: 176  EDI-RFGIKENVDFIAASFVRRPSDVLEIREILEEQK-ANISVFPKIENQEGIDNIAEIL 233

Query: 1014 QEADGIIISRGDLGIDLPPERVFMSQKTGIHKCNMAGKPVI-ITRVVDSMIDNLRPTRAE 1190
            + +DG++++RGD+G+++PPE+V M QK  I +CN  GKPVI  T+++DSM  N R TRAE
Sbjct: 234  EVSDGLMVARGDMGVEIPPEKVPMVQKDLIRQCNKLGKPVITATQMLDSMQRNPRATRAE 293

Query: 1191 ATDVANAVLDGTDGILLGAETLRGQYPVDAVSTVGRICAEAETV--YNQSLHFK------ 1346
            A+DVANA+ DGTD ++L  ET  G YP +AV T+  I   AE    Y + L  +      
Sbjct: 294  ASDVANAIYDGTDAVMLSGETAAGLYPEEAVKTMRNIAVSAEAAQDYKKLLSDRTKLVET 353

Query: 1347 KVVRHVGEPMAHEEXXXXXXXXXXXXXXXXXIVVFTFSGRAARLVAKYRPPMPVLAVVFP 1526
             +V  +G  +AH                   IV  T SG  AR ++KYRP   ++AV   
Sbjct: 354  SLVNAIGISVAH----------TALNLNVKAIVAATESGSTARTISKYRPHSDIIAVT-- 401

Query: 1527 REGSDPSKWRSYGTTQARQCFSVRGVYPLM 1616
                 PS+        ARQC  V GV P++
Sbjct: 402  -----PSE------ETARQCSIVWGVQPVV 420

---

>Q2FXM9:KPYK_STAA8 Pyruvate kinase - Staphylococcus aureus (strain NCTC 8325)|
          Length = 585

 Score =  244 bits (624), Expect = 8e-64
 Identities = 161/450 (35%), Positives = 248/450 (55%), Gaps = 9/450 (2%)
 Frame = +3

Query: 294  TKIVGTLGPNSHSVEVIEECLTAGMSVARFDFSWKDATYHQETLDNLRKAAQNVKKLCPI 473
            TKIV T+GP S S E+IE+ + AGM+VAR +FS      H+  +D +RK A+ + K+  I
Sbjct: 4    TKIVCTIGPASESEEMIEKLINAGMNVARLNFSHGSHEEHKGRIDTIRKVAKRLDKIVAI 63

Query: 474  MLDTVGPEIQVHNPTGGAIELIGGNHVTITPDLSKAPSADILPIKFGDLAKVVKKGDTLF 653
            +LDT GPEI+ HN   G IEL  GN V ++ +  +  + +   + + +L   V+      
Sbjct: 64   LLDTKGPEIRTHNMKDGIIELERGNEVIVSMNEVEG-TPEKFSVTYENLINDVQ------ 116

Query: 654  IGQYLFTGSETTSLWLEVMETSGEEVICFVKNTATLSGPIFTLHVSQVHISMPTLSEYDK 833
            +G Y+        L ++ ++ + +EV C + N+  L      +++  V +S+P ++E D 
Sbjct: 117  VGSYILLDDGLIELQVKDIDHAKKEVKCDILNSGELKNK-KGVNLPGVRVSLPGITEKDA 175

Query: 834  QVISTWGLDNSVDIISLSHTRSSEDVRELRAFLQSHNLQDTQIYAKIENAEGLEHFDEIL 1013
            + I  +G+  +VD I+ S  R   DV E+R  L+     +  ++ KIEN EG+++  EIL
Sbjct: 176  EDI-RFGIKENVDFIAASFVRRPSDVLEIREILEEQK-ANISVFPKIENQEGIDNIAEIL 233

Query: 1014 QEADGIIISRGDLGIDLPPERVFMSQKTGIHKCNMAGKPVI-ITRVVDSMIDNLRPTRAE 1190
            + +DG++++RGD+G+++PPE+V M QK  I +CN  GKPVI  T+++DSM  N R TRAE
Sbjct: 234  EVSDGLMVARGDMGVEIPPEKVPMVQKDLIRQCNKLGKPVITATQMLDSMQRNPRATRAE 293

Query: 1191 ATDVANAVLDGTDGILLGAETLRGQYPVDAVSTVGRICAEAETV--YNQSLHFK------ 1346
            A+DVANA+ DGTD ++L  ET  G YP +AV T+  I   AE    Y + L  +      
Sbjct: 294  ASDVANAIYDGTDAVMLSGETAAGLYPEEAVKTMRNIAVSAEAAQDYKKLLSDRTKLVET 353

Query: 1347 KVVRHVGEPMAHEEXXXXXXXXXXXXXXXXXIVVFTFSGRAARLVAKYRPPMPVLAVVFP 1526
             +V  +G  +AH                   IV  T SG  AR ++KYRP   ++AV   
Sbjct: 354  SLVNAIGISVAH----------TALNLNVKAIVAATESGSTARTISKYRPHSDIIAVT-- 401

Query: 1527 REGSDPSKWRSYGTTQARQCFSVRGVYPLM 1616
                 PS+        ARQC  V GV P++
Sbjct: 402  -----PSE------ETARQCSIVWGVQPVV 420

---

>Q2FG40:KPYK_STAA3 Pyruvate kinase - Staphylococcus aureus (strain USA300)|
          Length = 585

 Score =  244 bits (624), Expect = 8e-64
 Identities = 161/450 (35%), Positives = 248/450 (55%), Gaps = 9/450 (2%)
 Frame = +3

Query: 294  TKIVGTLGPNSHSVEVIEECLTAGMSVARFDFSWKDATYHQETLDNLRKAAQNVKKLCPI 473
            TKIV T+GP S S E+IE+ + AGM+VAR +FS      H+  +D +RK A+ + K+  I
Sbjct: 4    TKIVCTIGPASESEEMIEKLINAGMNVARLNFSHGSHEEHKGRIDTIRKVAKRLDKIVAI 63

Query: 474  MLDTVGPEIQVHNPTGGAIELIGGNHVTITPDLSKAPSADILPIKFGDLAKVVKKGDTLF 653
            +LDT GPEI+ HN   G IEL  GN V ++ +  +  + +   + + +L   V+      
Sbjct: 64   LLDTKGPEIRTHNMKDGIIELERGNEVIVSMNEVEG-TPEKFSVTYENLINDVQ------ 116

Query: 654  IGQYLFTGSETTSLWLEVMETSGEEVICFVKNTATLSGPIFTLHVSQVHISMPTLSEYDK 833
            +G Y+        L ++ ++ + +EV C + N+  L      +++  V +S+P ++E D 
Sbjct: 117  VGSYILLDDGLIELQVKDIDHAKKEVKCDILNSGELKNK-KGVNLPGVRVSLPGITEKDA 175

Query: 834  QVISTWGLDNSVDIISLSHTRSSEDVRELRAFLQSHNLQDTQIYAKIENAEGLEHFDEIL 1013
            + I  +G+  +VD I+ S  R   DV E+R  L+     +  ++ KIEN EG+++  EIL
Sbjct: 176  EDI-RFGIKENVDFIAASFVRRPSDVLEIREILEEQK-ANISVFPKIENQEGIDNIAEIL 233

Query: 1014 QEADGIIISRGDLGIDLPPERVFMSQKTGIHKCNMAGKPVI-ITRVVDSMIDNLRPTRAE 1190
            + +DG++++RGD+G+++PPE+V M QK  I +CN  GKPVI  T+++DSM  N R TRAE
Sbjct: 234  EVSDGLMVARGDMGVEIPPEKVPMVQKDLIRQCNKLGKPVITATQMLDSMQRNPRATRAE 293

Query: 1191 ATDVANAVLDGTDGILLGAETLRGQYPVDAVSTVGRICAEAETV--YNQSLHFK------ 1346
            A+DVANA+ DGTD ++L  ET  G YP +AV T+  I   AE    Y + L  +      
Sbjct: 294  ASDVANAIYDGTDAVMLSGETAAGLYPEEAVKTMRNIAVSAEAAQDYKKLLSDRTKLVET 353

Query: 1347 KVVRHVGEPMAHEEXXXXXXXXXXXXXXXXXIVVFTFSGRAARLVAKYRPPMPVLAVVFP 1526
             +V  +G  +AH                   IV  T SG  AR ++KYRP   ++AV   
Sbjct: 354  SLVNAIGISVAH----------TALNLNVKAIVAATESGSTARTISKYRPHSDIIAVT-- 401

Query: 1527 REGSDPSKWRSYGTTQARQCFSVRGVYPLM 1616
                 PS+        ARQC  V GV P++
Sbjct: 402  -----PSE------ETARQCSIVWGVQPVV 420

---

>P22360:KPYK_EMENI Pyruvate kinase - Emericella nidulans (Aspergillus nidulans)|
          Length = 526

 Score =  244 bits (622), Expect = 1e-63
 Identities = 171/537 (31%), Positives = 274/537 (51%), Gaps = 13/537 (2%)
 Frame = +3

Query: 216  NHMLLEEPVRLASVLAPAKPKVFPSLTKIVGTLGPNSHSVEVIEECLTAGMSVARFDFSW 395
            N M LE   +L + + PAK       T I+ T+GP ++SVE I     AG++V R +FS 
Sbjct: 12   NRMKLEWHSKLNTEMVPAKNF---RRTSIICTIGPKTNSVEKINALRRAGLNVVRMNFSH 68

Query: 396  KDATYHQETLDNLRKAA-QNVKKLCPIMLDTVGPEIQVHNPTGGA-IELIGGNHVTITPD 569
                YHQ  +D+ R+A  Q   +   I LDT GPEI+  N  G   I +  G+ + I+ D
Sbjct: 69   GSYEYHQSVIDHAREAEKQQAGRPVAIALDTKGPEIRTGNTVGDKDIPIKAGHEMNISTD 128

Query: 570  LSKAPSADI--LPIKFGDLAKVVKKGDTLFIGQYLFTGSETTSLWLEVMETSGEEVICFV 743
               A ++D   + + + ++ KV+  G  +++   + +        LEV++     V C  
Sbjct: 129  EQYATASDDQNMYVDYKNITKVISAGKLIYVDDGILSFEV-----LEVVDDKTLRVRCLN 183

Query: 744  K-NTATLSGPIFTLHVSQVHISMPTLSEYDKQVISTWGLDNSVDIISLSHTRSSEDVREL 920
              N ++  G    +++    + +P LSE D   +  +G+ N VD++  S  R   D+R +
Sbjct: 184  NGNISSRKG----VNLPGTDVDLPALSEKDISDLK-FGVKNKVDMVFASFIRRGSDIRHI 238

Query: 921  RAFLQSHNLQDTQIYAKIENAEGLEHFDEILQEADGIIISRGDLGIDLPPERVFMSQKTG 1100
            R  L     ++ QI AKIEN +G+ +FDEIL+E DG++++RGDLGI++P  +VF++QK  
Sbjct: 239  REVLGEEG-REIQIIAKIENQQGVNNFDEILEETDGVMVARGDLGIEIPAPKVFIAQKMM 297

Query: 1101 IHKCNMAGKPVI-ITRVVDSMIDNLRPTRAEATDVANAVLDGTDGILLGAETLRGQYPVD 1277
            I KCN+ GKPVI  T++++SM  N RPTRAE +DVANAVLDG D ++L  ET +G YP +
Sbjct: 298  IAKCNIKGKPVICATQMLESMTYNPRPTRAEVSDVANAVLDGADCVMLSGETAKGNYPCE 357

Query: 1278 AVSTVGRICAEAETVYNQSLHFKKVVRHVGEPMAHEEXXXXXXXXXXXXXXXXXIVVFTF 1457
            AV+ +   C  AE        F ++      P    E                 IVV T 
Sbjct: 358  AVTMMSETCLLAEVAIPHFNVFDELRNLAPRPTDTVESIAMAAVSASLELNAGAIVVLTT 417

Query: 1458 SGRAARLVAKYRPPMPVLAVVFPREGSDPSKWRSYGTTQARQCFSVRGVYPLMGSTDEAE 1637
            SG  AR+++KYRP  P++ V             S      R     RGV+P      + +
Sbjct: 418  SGNTARMISKYRPVCPIIMV-------------SRNPAATRYSHLYRGVWPFYFPEKKPD 464

Query: 1638 TG-GLTKEAYG--IKLALNYGRSVGIIKPYDRVIIFE----KIGDSSVVKIIECDDS 1787
                + +E     +K  +N+G  +GII   D ++  +     +G ++ V+++  +++
Sbjct: 465  FNVKIWQEDVDRRLKWGINHGLKLGIINKGDNIVCVQGWRGGMGHTNTVRVVPAEEN 521

---

>P30613:KPYR_HUMAN Pyruvate kinase isozymes R/L - Homo sapiens (Human)|
          Length = 574

 Score =  243 bits (621), Expect = 2e-63
 Identities = 164/456 (35%), Positives = 257/456 (56%), Gaps = 15/456 (3%)
 Frame = +3

Query: 294  TKIVGTLGPNSHSVEVIEECLTAGMSVARFDFSWKDATYHQETLDNLRKAAQNVK----- 458
            T I+ T+GP S SVE ++E + AGM++AR +FS     YH E++ N+R+A ++       
Sbjct: 88   TSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESFAGSPLS 147

Query: 459  -KLCPIMLDTVGPEIQVHNPTGGA---IELIGGNHVTIT--PDLSKAPSADILPIKFGDL 620
             +   I LDT GPEI+     GG    +EL+ G+ V +T  P      +A+ + + + ++
Sbjct: 148  YRPVAIALDTKGPEIRTGILQGGPESEVELVKGSQVLVTVDPAFRTRGNANTVWVDYPNI 207

Query: 621  AKVVKKGDTLFIGQYLFTGSETTSLWLEVMETSGEEVICFVKNTATLSGPIFTLHVSQVH 800
             +VV  G  ++I   L +        L V +   E ++  V+N   L G    +++    
Sbjct: 208  VRVVPVGGRIYIDDGLIS--------LVVQKIGPEGLVTQVENGGVL-GSRKGVNLPGAQ 258

Query: 801  ISMPTLSEYDKQVISTWGLDNSVDIISLSHTRSSEDVRELRAFL--QSHNLQDTQIYAKI 974
            + +P LSE D + +  +G+++ VDI+  S  R + DV  +RA L  + H ++   I +KI
Sbjct: 259  VDLPGLSEQDVRDLR-FGVEHGVDIVFASFVRKASDVAAVRAALGPEGHGIK---IISKI 314

Query: 975  ENAEGLEHFDEILQEADGIIISRGDLGIDLPPERVFMSQKTGIHKCNMAGKPVI-ITRVV 1151
            EN EG++ FDEIL+ +DGI+++RGDLGI++P E+VF++QK  I +CN+AGKPV+  T+++
Sbjct: 315  ENHEGVKRFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQML 374

Query: 1152 DSMIDNLRPTRAEATDVANAVLDGTDGILLGAETLRGQYPVDAVSTVGRICAEAE-TVYN 1328
            +SMI   RPTRAE +DVANAVLDG D I+L  ET +G +PV+AV     I  EAE  VY+
Sbjct: 375  ESMITKPRPTRAETSDVANAVLDGADCIMLSGETAKGNFPVEAVKMQHAIAREAEAAVYH 434

Query: 1329 QSLHFKKVVRHVGEPMAHEEXXXXXXXXXXXXXXXXXIVVFTFSGRAARLVAKYRPPMPV 1508
            + L F+++ R         E                 I+V T +GR+A+L+++YRP   V
Sbjct: 435  RQL-FEELRRAAPLSRDPTEVTAIGAVEAAFKCCAAAIIVLTTTGRSAQLLSRYRPRAAV 493

Query: 1509 LAVVFPREGSDPSKWRSYGTTQARQCFSVRGVYPLM 1616
            +AV             +     ARQ    RGV+PL+
Sbjct: 494  IAV-------------TRSAQAARQVHLCRGVFPLL 516

---

>P00548:KPYK_CHICK Pyruvate kinase muscle isozyme - Gallus gallus (Chicken)|
          Length = 530

 Score =  243 bits (621), Expect = 2e-63
 Identities = 165/492 (33%), Positives = 261/492 (53%), Gaps = 12/492 (2%)
 Frame = +3

Query: 294  TKIVGTLGPNSHSVEVIEECLTAGMSVARFDFSWKDATYHQETLDNLRKAAQNVK----- 458
            T I+ T+GP S SV+ ++E + +GM+VAR +FS     YH+ T+ N+R+A ++       
Sbjct: 44   TGIICTIGPASRSVDKLKEMIKSGMNVARLNFSHGTHEYHEGTIKNVREATESFASDPIT 103

Query: 459  -KLCPIMLDTVGPEIQVHNPTGGA---IELIGGNHVTITPDLSKAPSAD--ILPIKFGDL 620
             +   I LDT GPEI+     G     +EL  G  + +T D +   + D  +L + + +L
Sbjct: 104  YRPVAIALDTKGPEIRTGLIKGSGTAEVELKKGAALKVTLDNAFMENCDENVLWVDYKNL 163

Query: 621  AKVVKKGDTLFIGQYLFTGSETTSLWLEVMETSGEEVICFVKNTATLSGPIFTLHVSQVH 800
             KV+  G  +++   L +        L V E   + V+  V+N   L G    +++    
Sbjct: 164  IKVIDVGSKIYVDDGLIS--------LLVKEKGKDFVMTEVENGGML-GSKKGVNLPGAA 214

Query: 801  ISMPTLSEYDKQVISTWGLDNSVDIISLSHTRSSEDVRELRAFLQSHNLQDTQIYAKIEN 980
            + +P +SE D Q +  +G++ +VD++  S  R + DV  +R  L     +  +I +KIEN
Sbjct: 215  VDLPAVSEKDIQDLK-FGVEQNVDMVFASFIRKAADVHAVRKVLGEKG-KHIKIISKIEN 272

Query: 981  AEGLEHFDEILQEADGIIISRGDLGIDLPPERVFMSQKTGIHKCNMAGKPVI-ITRVVDS 1157
             EG+  FDEI++ +DGI+++RGDLGI++P E+VF++QK  I +CN AGKP+I  T++++S
Sbjct: 273  HEGVRRFDEIMEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPIICATQMLES 332

Query: 1158 MIDNLRPTRAEATDVANAVLDGTDGILLGAETLRGQYPVDAVSTVGRICAEAETVYNQSL 1337
            MI   RPTRAE +DVANAVLDG D I+L  ET +G YP++AV     I  EAE       
Sbjct: 333  MIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHAIAREAEAAMFHRQ 392

Query: 1338 HFKKVVRHVGEPMAHEEXXXXXXXXXXXXXXXXXIVVFTFSGRAARLVAKYRPPMPVLAV 1517
             F++++RH        +                 ++V T SGR+A LV++YRP  P++AV
Sbjct: 393  QFEEILRHSVHHREPADAMAAGAVEASFKCLAAALIVMTESGRSAHLVSRYRPRAPIIAV 452

Query: 1518 VFPREGSDPSKWRSYGTTQARQCFSVRGVYPLMGSTDEAETGGLTKEAYGIKLALNYGRS 1697
                         +     ARQ    RGV+P++     A           + L +N G++
Sbjct: 453  -------------TRNDQTARQAHLYRGVFPVL-CKQPAHDAWAEDVDLRVNLGMNVGKA 498

Query: 1698 VGIIKPYDRVII 1733
             G  K  D VI+
Sbjct: 499  RGFFKTGDLVIV 510

---

>P30616:KPYK2_TRYBB Pyruvate kinase 2 - Trypanosoma brucei brucei|
          Length = 499

 Score =  240 bits (612), Expect = 2e-62
 Identities = 144/411 (35%), Positives = 235/411 (57%), Gaps = 4/411 (0%)
 Frame = +3

Query: 297  KIVGTLGPNSHSVEVIEECLTAGMSVARFDFSWKDATYHQETLDNLRKAAQNVKKLCPIM 476
            +IV T+GP++ SVE ++  + +GMSVAR +FS     YHQ T++N+R AA  +     I 
Sbjct: 23   RIVCTIGPSTQSVEALKNLMKSGMSVARMNFSHGSHEYHQTTINNVRAAAAELGLHIGIA 82

Query: 477  LDTVGPEIQVHNPTGGAIELIGGNHVTITPD--LSKAPSADILPIKFGDLAKVVKKGDTL 650
            LDT GPEI+      G +    G+ V +T D    K  + +   I +  L K V  G ++
Sbjct: 83   LDTKGPEIRTGLFKDGEVTFAPGDIVCVTTDPAYEKVGTKEKFYIDYPQLTKAVPVGGSI 142

Query: 651  FIGQYLFTGSETTSLWLEVMETSGEEVI-CFVKNTATLSGPIFTLHVSQVHISMPTLSEY 827
            ++   + T        L V+    +  + C V N   L+     +++    + +P +SE 
Sbjct: 143  YVDDGVMT--------LRVLSKEDDRTLKCHVNNHHRLTDRR-GINLPGCEVDLPAVSEK 193

Query: 828  DKQVISTWGLDNSVDIISLSHTRSSEDVRELRAFLQSHNLQDTQIYAKIENAEGLEHFDE 1007
            D++ +  +G+   VD+I  S  R++E VRE+RA L     +D  I +KIEN +G+++ D 
Sbjct: 194  DRKDLE-FGVAQGVDMIFASFIRTAEQVREVRAALGEKG-KDILIISKIENHQGVQNIDS 251

Query: 1008 ILQEADGIIISRGDLGIDLPPERVFMSQKTGIHKCNMAGKPVII-TRVVDSMIDNLRPTR 1184
            I++ ++GI+++RGDLG+++P E+V ++Q   I KCN+ GKPVI  T++++SM  N RPTR
Sbjct: 252  IIEASNGIMVARGDLGVEIPAEKVCVAQMCIISKCNVVGKPVICATQMLESMTSNPRPTR 311

Query: 1185 AEATDVANAVLDGTDGILLGAETLRGQYPVDAVSTVGRICAEAETVYNQSLHFKKVVRHV 1364
            AE +DVANAVL+G D ++L  ET +G+YP + V  + RIC EA++  + ++ F  +    
Sbjct: 312  AEVSDVANAVLNGADCVMLSGETAKGKYPNEVVQYMARICVEAQSATHDTVMFNSIKNLQ 371

Query: 1365 GEPMAHEEXXXXXXXXXXXXXXXXXIVVFTFSGRAARLVAKYRPPMPVLAV 1517
              PM  EE                 ++V + +GR+ARL++KYRP  P++ V
Sbjct: 372  KIPMCPEEAVCSSAVASAFEVQAKAMLVLSNTGRSARLISKYRPNCPIICV 422

---

>Q8CS69:KPYK_STAES Pyruvate kinase - Staphylococcus epidermidis (strain ATCC 12228)|
          Length = 585

 Score =  239 bits (611), Expect = 3e-62
 Identities = 160/450 (35%), Positives = 242/450 (53%), Gaps = 9/450 (2%)
 Frame = +3

Query: 294  TKIVGTLGPNSHSVEVIEECLTAGMSVARFDFSWKDATYHQETLDNLRKAAQNVKKLCPI 473
            TKIV T+GP S S E++E+ + AGM+VAR +FS      H+  +D +RK A+ + K   +
Sbjct: 4    TKIVCTIGPASESEEMLEKLMNAGMNVARLNFSHGSHEEHKARIDTIRKVAKRLNKTIGL 63

Query: 474  MLDTVGPEIQVHNPTGGAIELIGGNHVTITPDLSKAPSADILPIKFGDLAKVVKKGDTLF 653
            +LDT GPEI+ HN   G I L  G  V ++ +  +  + +   + + +L   V       
Sbjct: 64   LLDTKGPEIRTHNMKDGLIVLEKGKEVIVSMNEVEG-TPEKFSVTYENLINDVN------ 116

Query: 654  IGQYLFTGSETTSLWLEVMETSGEEVICFVKNTATLSGPIFTLHVSQVHISMPTLSEYDK 833
            IG Y+        L ++ +     EV C + NT  L      +++  V +++P +++ D 
Sbjct: 117  IGSYILLDDGLVELQVKEINKDKGEVKCDILNTGELKNK-KGVNLPGVKVNLPGITDKDA 175

Query: 834  QVISTWGLDNSVDIISLSHTRSSEDVRELRAFLQSHNLQDTQIYAKIENAEGLEHFDEIL 1013
              I  +G+  +VD I+ S  R   DV ++R  L+    + T I+ KIEN EG+++ +EIL
Sbjct: 176  DDI-RFGIKENVDFIAASFVRRPSDVLDIRQILEEEKAEIT-IFPKIENQEGIDNIEEIL 233

Query: 1014 QEADGIIISRGDLGIDLPPERVFMSQKTGIHKCNMAGKPVI-ITRVVDSMIDNLRPTRAE 1190
            + +DG++++RGD+G+++PPE V M QK  I KCN  GKPVI  T+++DSM  N R TRAE
Sbjct: 234  EVSDGLMVARGDMGVEIPPESVPMVQKDLIRKCNKLGKPVITATQMLDSMQRNPRATRAE 293

Query: 1191 ATDVANAVLDGTDGILLGAETLRGQYPVDAVSTVGRICAEAETV--YNQSLHFK------ 1346
            A+DVANA+ DGTD ++L  ET  GQYP +AV T+  I   AE    Y + L  +      
Sbjct: 294  ASDVANAIYDGTDAVMLSGETAAGQYPEEAVKTMRNIAVSAEAAQDYKKLLSDRTKLVET 353

Query: 1347 KVVRHVGEPMAHEEXXXXXXXXXXXXXXXXXIVVFTFSGRAARLVAKYRPPMPVLAVVFP 1526
             +V  +G  +AH                   IV  T SG  AR ++KYRP   ++AV   
Sbjct: 354  SLVNAIGVSVAH----------TALNLNVKAIVAATESGSTARTISKYRPHSDIIAVT-- 401

Query: 1527 REGSDPSKWRSYGTTQARQCFSVRGVYPLM 1616
                 PS+        ARQC  V GV P++
Sbjct: 402  -----PSE------KTARQCAIVWGVNPVV 420

---

>Q5HNK7:KPYK_STAEQ Pyruvate kinase - Staphylococcus epidermidis (strain ATCC 35984 /|
            RP62A)
          Length = 585

 Score =  239 bits (611), Expect = 3e-62
 Identities = 160/450 (35%), Positives = 242/450 (53%), Gaps = 9/450 (2%)
 Frame = +3

Query: 294  TKIVGTLGPNSHSVEVIEECLTAGMSVARFDFSWKDATYHQETLDNLRKAAQNVKKLCPI 473
            TKIV T+GP S S E++E+ + AGM+VAR +FS      H+  +D +RK A+ + K   +
Sbjct: 4    TKIVCTIGPASESEEMLEKLMNAGMNVARLNFSHGSHEEHKARIDTIRKVAKRLNKTIGL 63

Query: 474  MLDTVGPEIQVHNPTGGAIELIGGNHVTITPDLSKAPSADILPIKFGDLAKVVKKGDTLF 653
            +LDT GPEI+ HN   G I L  G  V ++ +  +  + +   + + +L   V       
Sbjct: 64   LLDTKGPEIRTHNMKDGLIVLEKGKEVIVSMNEVEG-TPEKFSVTYENLINDVN------ 116

Query: 654  IGQYLFTGSETTSLWLEVMETSGEEVICFVKNTATLSGPIFTLHVSQVHISMPTLSEYDK 833
            IG Y+        L ++ +     EV C + NT  L      +++  V +++P +++ D 
Sbjct: 117  IGSYILLDDGLVELQVKEINKDKGEVKCDILNTGELKNK-KGVNLPGVKVNLPGITDKDA 175

Query: 834  QVISTWGLDNSVDIISLSHTRSSEDVRELRAFLQSHNLQDTQIYAKIENAEGLEHFDEIL 1013
              I  +G+  +VD I+ S  R   DV ++R  L+    + T I+ KIEN EG+++ +EIL
Sbjct: 176  DDI-RFGIKENVDFIAASFVRRPSDVLDIRQILEEEKAEIT-IFPKIENQEGIDNIEEIL 233

Query: 1014 QEADGIIISRGDLGIDLPPERVFMSQKTGIHKCNMAGKPVI-ITRVVDSMIDNLRPTRAE 1190
            + +DG++++RGD+G+++PPE V M QK  I KCN  GKPVI  T+++DSM  N R TRAE
Sbjct: 234  EVSDGLMVARGDMGVEIPPESVPMVQKDLIRKCNKLGKPVITATQMLDSMQRNPRATRAE 293

Query: 1191 ATDVANAVLDGTDGILLGAETLRGQYPVDAVSTVGRICAEAETV--YNQSLHFK------ 1346
            A+DVANA+ DGTD ++L  ET  GQYP +AV T+  I   AE    Y + L  +      
Sbjct: 294  ASDVANAIYDGTDAVMLSGETAAGQYPEEAVKTMRNIAVSAEAAQDYKKLLSDRTKLVET 353

Query: 1347 KVVRHVGEPMAHEEXXXXXXXXXXXXXXXXXIVVFTFSGRAARLVAKYRPPMPVLAVVFP 1526
             +V  +G  +AH                   IV  T SG  AR ++KYRP   ++AV   
Sbjct: 354  SLVNAIGVSVAH----------TALNLNVKAIVAATESGSTARTISKYRPHSDIIAVT-- 401

Query: 1527 REGSDPSKWRSYGTTQARQCFSVRGVYPLM 1616
                 PS+        ARQC  V GV P++
Sbjct: 402  -----PSE------KTARQCAIVWGVNPVV 420

---

>P30615:KPYK1_TRYBB Pyruvate kinase 1 - Trypanosoma brucei brucei|
          Length = 499

 Score =  239 bits (611), Expect = 3e-62
 Identities = 143/411 (34%), Positives = 235/411 (57%), Gaps = 4/411 (0%)
 Frame = +3

Query: 297  KIVGTLGPNSHSVEVIEECLTAGMSVARFDFSWKDATYHQETLDNLRKAAQNVKKLCPIM 476
            +IV T+GP++ SVE ++  + +GMSVAR +FS     YHQ T++N+R AA  +     I 
Sbjct: 23   RIVCTIGPSTQSVEALKNLMKSGMSVARMNFSHGSHEYHQTTINNVRAAAAELGLHIGIA 82

Query: 477  LDTVGPEIQVHNPTGGAIELIGGNHVTITPD--LSKAPSADILPIKFGDLAKVVKKGDTL 650
            LDT GPEI+      G +    G+ V +T D    K  + +   I +  L   V+ G ++
Sbjct: 83   LDTKGPEIRTGLFKDGEVSFAPGDIVCVTTDPAYEKVGTKEKFYIDYPQLTNAVRPGGSI 142

Query: 651  FIGQYLFTGSETTSLWLEVMETSGEEVI-CFVKNTATLSGPIFTLHVSQVHISMPTLSEY 827
            ++   + T        L V+    +  + C V N   L+     +++    + +P +SE 
Sbjct: 143  YVDDGVMT--------LRVVSKEDDRTLKCHVNNHHRLTDRR-GINLPGCEVDLPAVSEK 193

Query: 828  DKQVISTWGLDNSVDIISLSHTRSSEDVRELRAFLQSHNLQDTQIYAKIENAEGLEHFDE 1007
            D++ +  +G+   VD+I  S  R++E VRE+RA L     +D  I +KIEN +G+++ D 
Sbjct: 194  DRKDLE-FGVAQGVDMIFASFIRTAEQVREVRAALGEKG-KDILIISKIENHQGVQNIDS 251

Query: 1008 ILQEADGIIISRGDLGIDLPPERVFMSQKTGIHKCNMAGKPVII-TRVVDSMIDNLRPTR 1184
            I++ ++GI+++RGDLG+++P E+V ++Q   I KCN+ GKPVI  T++++SM  N RPTR
Sbjct: 252  IIEASNGIMVARGDLGVEIPAEKVCVAQMCIISKCNVVGKPVICATQMLESMTSNPRPTR 311

Query: 1185 AEATDVANAVLDGTDGILLGAETLRGQYPVDAVSTVGRICAEAETVYNQSLHFKKVVRHV 1364
            AE +DVANAVL+G D ++L  ET +G+YP + V  + RIC EA++  + ++ F  +    
Sbjct: 312  AEVSDVANAVLNGADCVMLSGETAKGKYPNEVVQYMARICVEAQSATHDTVMFNSIKNLQ 371

Query: 1365 GEPMAHEEXXXXXXXXXXXXXXXXXIVVFTFSGRAARLVAKYRPPMPVLAV 1517
              PM  EE                 ++V + +GR+ARL++KYRP  P++ V
Sbjct: 372  KIPMCPEEAVCSSAVASAFEVQAKAMLVLSNTGRSARLISKYRPNCPIICV 422

---

>Q92122:KPYK_XENLA Pyruvate kinase muscle isozyme - Xenopus laevis (African clawed frog)|
          Length = 527

 Score =  238 bits (606), Expect = 1e-61
 Identities = 166/492 (33%), Positives = 263/492 (53%), Gaps = 12/492 (2%)
 Frame = +3

Query: 294  TKIVGTLGPNSHSVEVIEECLTAGMSVARFDFSWKDATYHQETLDNLRKAAQNVK----- 458
            T I+ T+GP S SVE+++E + +GM++AR +FS     YH  T+ N+R+A +++      
Sbjct: 41   TGIICTIGPASRSVEMLKEMIKSGMNIARLNFSHGTHEYHAGTIKNVREATESLASNPIH 100

Query: 459  -KLCPIMLDTVGPEIQVHNPTGGA---IELIGGNHVTITPDLSKAPSAD--ILPIKFGDL 620
             +   + LDT GPEI+     G     +EL  G  + IT D +   + D  +L + + +L
Sbjct: 101  YRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATMRITLDDAFQENCDENVLWVDYKNL 160

Query: 621  AKVVKKGDTLFIGQYLFTGSETTSLWLEVMETSGEEVICFVKNTATLSGPIFTLHVSQVH 800
             KVVK G  +++   L +        L V E   +  +  ++N   L G    +++    
Sbjct: 161  TKVVKPGSKIYVDDGLIS--------LLVKEIGPDFCVTEIENGGML-GSKKGVNLPGAA 211

Query: 801  ISMPTLSEYDKQVISTWGLDNSVDIISLSHTRSSEDVRELRAFLQSHNLQDTQIYAKIEN 980
            + +P +S  D Q +  +G++  VD++  S  R + DV E+R  L     ++ +I +KIEN
Sbjct: 212  VDLPAVSSKDIQDLQ-FGVEQDVDMVFASFIRKAADVHEVREVLGEKG-KNIKIISKIEN 269

Query: 981  AEGLEHFDEILQEADGIIISRGDLGIDLPPERVFMSQKTGIHKCNMAGKPVI-ITRVVDS 1157
             EG+  FDEIL+ +DGI+++RGDLGI++P E+VF++QK  I +CN AGKPVI  T++++S
Sbjct: 270  HEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLES 329

Query: 1158 MIDNLRPTRAEATDVANAVLDGTDGILLGAETLRGQYPVDAVSTVGRICAEAETVYNQSL 1337
            MI   RPTRAE +DVANAVLDG D I+L  ET +G YP++AV     I  EAE       
Sbjct: 330  MIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHAIAREAEAAIFHRQ 389

Query: 1338 HFKKVVRHVGEPMAHEEXXXXXXXXXXXXXXXXXIVVFTFSGRAARLVAKYRPPMPVLAV 1517
             F+++ R         E                 I+V T SGR+A L+++YRP  P+++V
Sbjct: 390  LFEELRRVSPLTRDPTEATAVGAVEASFKCSSGAIIVLTKSGRSAHLLSRYRPRAPIISV 449

Query: 1518 VFPREGSDPSKWRSYGTTQARQCFSVRGVYPLMGSTDEAETGGLTKEAYGIKLALNYGRS 1697
               R G             ARQ    RG++P++      E      ++  +  A++ G++
Sbjct: 450  T--RNGQ-----------TARQAHLYRGIFPVLYREAVHEAWAEDVDS-RVNFAMDIGKA 495

Query: 1698 VGIIKPYDRVII 1733
             G  K  D VI+
Sbjct: 496  RGFFKSGDVVIV 507

---

>P12928:KPYR_RAT Pyruvate kinase isozymes R/L - Rattus norvegicus (Rat)|
          Length = 574

 Score =  237 bits (604), Expect = 2e-61
 Identities = 161/454 (35%), Positives = 252/454 (55%), Gaps = 13/454 (2%)
 Frame = +3

Query: 294  TKIVGTLGPNSHSVEVIEECLTAGMSVARFDFSWKDATYHQETLDNLRKAAQNVK----- 458
            T I+ T+GP S SV+ ++E + AGM++AR +FS     YH E++ N+R+A ++       
Sbjct: 88   TSIIATIGPASRSVDRLKEMIKAGMNIARLNFSHGSHEYHAESIANIREATESFATSPLS 147

Query: 459  -KLCPIMLDTVGPEIQVHNPTGGA---IELIGGNHVTIT--PDLSKAPSADILPIKFGDL 620
             +   I LDT GPEI+     GG    +E++ G+ V +T  P       A  + + + ++
Sbjct: 148  YRPVAIALDTKGPEIRTGVLQGGPESEVEIVKGSQVLVTVDPKFQTRGDAKTVWVDYHNI 207

Query: 621  AKVVKKGDTLFIGQYLFTGSETTSLWLEVMETSGEEVICFVKNTATLSGPIFTLHVSQVH 800
             +VV  G  ++I   L +        L V +   E ++  V++   L G    +++    
Sbjct: 208  TRVVAVGGRIYIDDGLIS--------LVVQKIGPEGLVTEVEHGGIL-GSRKGVNLPNTE 258

Query: 801  ISMPTLSEYDKQVISTWGLDNSVDIISLSHTRSSEDVRELRAFLQSHNLQDTQIYAKIEN 980
            + +P LSE D   +  +G+ ++VDII  S  R + DV  +R  L     Q+ +I +KIEN
Sbjct: 259  VDLPGLSEQDLLDLR-FGVQHNVDIIFASFVRKASDVLAVRDALGPEG-QNIKIISKIEN 316

Query: 981  AEGLEHFDEILQEADGIIISRGDLGIDLPPERVFMSQKTGIHKCNMAGKPVI-ITRVVDS 1157
             EG++ FDEIL+ +DGI+++RGDLGI++P E+VF++QK  I +CN+AGKPV+  T++++S
Sbjct: 317  HEGVKKFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLES 376

Query: 1158 MIDNLRPTRAEATDVANAVLDGTDGILLGAETLRGQYPVDAVSTVGRICAEAE-TVYNQS 1334
            MI   RPTRAE +DVANAVLDG D I+L  ET +G +PV+AV     I  EAE  VY++ 
Sbjct: 377  MITKARPTRAETSDVANAVLDGADCIMLSGETAKGSFPVEAVMMQHAIAREAEAAVYHRQ 436

Query: 1335 LHFKKVVRHVGEPMAHEEXXXXXXXXXXXXXXXXXIVVFTFSGRAARLVAKYRPPMPVLA 1514
            L F+++ R         E                 I+V T +GR+A+L+++YRP   V+A
Sbjct: 437  L-FEELRRAAPLSRDPTEVTAIGAVEASFKCCAAAIIVLTKTGRSAQLLSQYRPRAAVIA 495

Query: 1515 VVFPREGSDPSKWRSYGTTQARQCFSVRGVYPLM 1616
            V             +     ARQ    RGV+PL+
Sbjct: 496  V-------------TRSAQAARQVHLSRGVFPLL 516

---

>Q7RVA8:KPYK_NEUCR Pyruvate kinase - Neurospora crassa|
          Length = 527

 Score =  234 bits (598), Expect = 8e-61
 Identities = 161/511 (31%), Positives = 263/511 (51%), Gaps = 15/511 (2%)
 Frame = +3

Query: 294  TKIVGTLGPNSHSVEVIEECLTAGMSVARFDFSWKDATYHQETLDNLRKAAQ-NVKKLCP 470
            T I+ T+GP ++SVE I +   AG++V R +FS     YHQ  +DN R+A + +  +   
Sbjct: 34   TSIICTIGPKTNSVEAINKLRDAGLNVVRMNFSHGSYEYHQSVIDNARQAEKVHPGRPIA 93

Query: 471  IMLDTVGPEIQVHNPTGGA-IELIGGNHVTITPDLSKAPSADI--LPIKFGDLAKVVKKG 641
            I LDT GPEI+  N      I +  G  + IT D        I  + + + ++ KV+  G
Sbjct: 94   IALDTKGPEIRTGNTKNDEDIPISAGTILNITTDEKYKDECTIEHMYVDYVNITKVIAPG 153

Query: 642  DTLFIGQYLFTGSETTSLWLEVMETSGEEVICFVKNTATLSGPIFT---LHVSQVHISMP 812
              +++   +        L  EV+E   ++ I   K  A  +G I +   +++    + +P
Sbjct: 154  RIIYVDDGV--------LAFEVLEIVDDKTI---KVKARNNGYISSRKGVNLPNTDVDLP 202

Query: 813  TLSEYDKQVISTWGLDNSVDIISLSHTRSSEDVRELRAFLQSHNLQDTQIYAKIENAEGL 992
             LSE DK  +  +G+ N VD++  S  R  +D++++R  L     Q  QI AKIEN +GL
Sbjct: 203  ALSEKDKADLR-FGVKNKVDMVFASFIRRGQDIKDIREVLGEDGKQ-IQIIAKIENRQGL 260

Query: 993  EHFDEILQEADGIIISRGDLGIDLPPERVFMSQKTGIHKCNMAGKPVI-ITRVVDSMIDN 1169
             +F EIL E DG++++RGDLGI++P   VF +QK  I  CN+AGKPVI  T++++SMI N
Sbjct: 261  NNFAEILAETDGVMVARGDLGIEIPAAEVFAAQKKIIAMCNIAGKPVICATQMLESMIKN 320

Query: 1170 LRPTRAEATDVANAVLDGTDGILLGAETLRGQYPVDAVSTVGRICAEAETVYNQSLHFKK 1349
             RPTRAE +DV NAV DG D ++L  ET +G YP +AV  +     +AE       HF++
Sbjct: 321  PRPTRAEISDVGNAVTDGADCVMLSGETAKGAYPTEAVREMSEAVLKAENTIPYVSHFEE 380

Query: 1350 VVRHVGEPMAHEEXXXXXXXXXXXXXXXXXIVVFTFSGRAARLVAKYRPPMPVLAVVFPR 1529
            +      P++  E                 I+V + SG +ARL++KYRP  P++ +    
Sbjct: 381  LCSLAKRPVSIVESCAMASVRASLDLNAAAILVLSTSGESARLISKYRPVCPIIMI---- 436

Query: 1530 EGSDPSKWRSYGTTQARQCFSVRGVYPLM---GSTDEAETGGLTKEAYGIKLALNYGRSV 1700
                     +   + +R     RGVYP +      D ++          IK  L++G  +
Sbjct: 437  ---------TRNDSASRYAHLYRGVYPFLFPESKPDFSKVNWQEDVDRRIKWGLSHGIGL 487

Query: 1701 GIIKPYDRVIIFE----KIGDSSVVKIIECD 1781
             ++   + V++ +     +G+++  +I++ D
Sbjct: 488  KVLNEGETVVVVQGWKGGMGNTNTFRIVKAD 518

---

>P31865:KPYK_TRIRE Pyruvate kinase - Trichoderma reesei (Hypocrea jecorina)|
          Length = 538

 Score =  234 bits (597), Expect = 1e-60
 Identities = 149/447 (33%), Positives = 240/447 (53%), Gaps = 6/447 (1%)
 Frame = +3

Query: 294  TKIVGTLGPNSHSVEVIEECLTAGMSVARFDFSWKDATYHQETLDNLRKA-AQNVKKLCP 470
            T I+ T+GP ++SVE + +   AG++VAR +FS     YHQ  +DN+R + A +  +   
Sbjct: 44   TSIICTIGPKTNSVEALNKLRDAGLNVARMNFSHGSYEYHQSVIDNVRASVAAHPGRPVA 103

Query: 471  IMLDTVGPEIQVHNPTGGA-IELIGGNHVTITPDLSKAPSADI--LPIKFGDLAKVVKKG 641
            I LDT GPEI+  N  G   I +  G  +  T D   A + D   + + + ++ KV++ G
Sbjct: 104  IALDTKGPEIRTGNTAGDVDIPISAGTVMNFTTDEKYATACDTQNMYVDYKNITKVIQPG 163

Query: 642  DTLFIGQYLFTGSETTSLWLEVMETSGEEVI-CFVKNTATLSGPIFTLHVSQVHISMPTL 818
              +++   +        L  +V+    ++ +    +N   +S     +++    + +P L
Sbjct: 164  RVIYVDDGV--------LAFDVLSIKDDQTVEVRARNNGFISSRK-GVNLPNTDVDLPAL 214

Query: 819  SEYDKQVISTWGLDNSVDIISLSHTRSSEDVRELRAFLQSHNLQDTQIYAKIENAEGLEH 998
            SE DK  +  +G+ N+VD++  S  R ++D++++R  L     Q  QI AKIEN +GL +
Sbjct: 215  SEKDKADLR-FGVKNNVDMVFASFIRRAQDIKDIRDVLGPEGKQ-IQIIAKIENRQGLNN 272

Query: 999  FDEILQEADGIIISRGDLGIDLPPERVFMSQKTGIHKCNMAGKPVI-ITRVVDSMIDNLR 1175
            F EIL+E DG++++RGDLGI++P   VF +QK  I  CN+AGKPVI  T++++SMI N R
Sbjct: 273  FAEILEETDGVMVARGDLGIEIPAAEVFAAQKKMIAMCNIAGKPVICATQMLESMIKNPR 332

Query: 1176 PTRAEATDVANAVLDGTDGILLGAETLRGQYPVDAVSTVGRICAEAETVYNQSLHFKKVV 1355
            PTRAE +DV NAV DG D ++L  ET +G YP +++  +     +AE       HF+++ 
Sbjct: 333  PTRAEISDVGNAVTDGADCVMLSGETAKGNYPAESIHEMHEASLKAENTIPYVSHFEEMC 392

Query: 1356 RHVGEPMAHEEXXXXXXXXXXXXXXXXXIVVFTFSGRAARLVAKYRPPMPVLAVVFPREG 1535
              V  P++  E                 I+V + SG +ARL++KYRP  P+  V      
Sbjct: 393  TLVKRPVSTVESCAMAAVRASLDLGAGGIIVLSTSGDSARLLSKYRPVCPIFMV------ 446

Query: 1536 SDPSKWRSYGTTQARQCFSVRGVYPLM 1616
                   +   T +R     RGVYP +
Sbjct: 447  -------TRNPTTSRFSHLYRGVYPFL 466

---

>P53657:KPYR_MOUSE Pyruvate kinase isozymes R/L - Mus musculus (Mouse)|
          Length = 574

 Score =  234 bits (596), Expect = 1e-60
 Identities = 167/493 (33%), Positives = 266/493 (53%), Gaps = 13/493 (2%)
 Frame = +3

Query: 294  TKIVGTLGPNSHSVEVIEECLTAGMSVARFDFSWKDATYHQETLDNLRKAAQNVK----- 458
            T I+ T+GP S SV+ ++E + AGM++AR +FS     YH E++ N+R+AA++       
Sbjct: 88   TSIIATIGPASRSVDRLKEMIKAGMNIARLNFSHGSHEYHAESIANIREAAESFATSPLS 147

Query: 459  -KLCPIMLDTVGPEIQVHNPTGGA---IELIGGNHVTIT--PDLSKAPSADILPIKFGDL 620
             +   I LDT GPEI+     GG    +E++ G+ V +T  P       A  + + + ++
Sbjct: 148  YRPVAIALDTKGPEIRTGVLQGGPESEVEIVKGSQVLVTVDPKFRTRGDAKTVWVDYHNI 207

Query: 621  AKVVKKGDTLFIGQYLFTGSETTSLWLEVMETSGEEVICFVKNTATLSGPIFTLHVSQVH 800
             +VV  G  ++I   L +        L V +   E ++  V++   L G    +++    
Sbjct: 208  TQVVAVGGRIYIDDGLIS--------LVVRKIGPEGLVTEVEHGGFL-GNRKGVNLPNAE 258

Query: 801  ISMPTLSEYDKQVISTWGLDNSVDIISLSHTRSSEDVRELRAFLQSHNLQDTQIYAKIEN 980
            + +P LSE D   +  +G+++ VDII  S  R + DV  +R  L     +  +I +KIEN
Sbjct: 259  VDLPGLSEQDLLDLR-FGVEHYVDIIFASFVRKASDVVAVRDALGPEG-RGIKIISKIEN 316

Query: 981  AEGLEHFDEILQEADGIIISRGDLGIDLPPERVFMSQKTGIHKCNMAGKPVI-ITRVVDS 1157
             EG++ FDEIL+ +DGI+++RGDLGI++P E+VF++QK  I +CN+AGKPV+  T++++S
Sbjct: 317  HEGVKKFDEILEVSDGIMMARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLES 376

Query: 1158 MIDNLRPTRAEATDVANAVLDGTDGILLGAETLRGQYPVDAVSTVGRICAEAE-TVYNQS 1334
            MI   RPTRAE +DVANAVLDG D I+L  ET +G +PV+AV     I  EAE  VY++ 
Sbjct: 377  MITKARPTRAETSDVANAVLDGADCIMLSGETAKGSFPVEAVKMQHAIAREAEAAVYHRQ 436

Query: 1335 LHFKKVVRHVGEPMAHEEXXXXXXXXXXXXXXXXXIVVFTFSGRAARLVAKYRPPMPVLA 1514
            L F+++ R         E                 I+V T +GR+A+L+++YRP   V+A
Sbjct: 437  L-FEELRRAAPLSRDPTEVTAIGAVEASFKCCAAAIIVLTKTGRSAQLLSRYRPRAAVIA 495

Query: 1515 VVFPREGSDPSKWRSYGTTQARQCFSVRGVYPLMGSTDEAETGGLTKEAYGIKLALNYGR 1694
            V             +     ARQ    RGV+PL+   +  E          ++  +  G+
Sbjct: 496  V-------------TRSAQAARQVHLSRGVFPLL-YREPPEAVWADDVDRRVQFGIESGK 541

Query: 1695 SVGIIKPYDRVII 1733
              G ++  D VI+
Sbjct: 542  LRGFLRVGDLVIV 554

---

>Q4L739:KPYK_STAHJ Pyruvate kinase - Staphylococcus haemolyticus (strain JCSC1435)|
          Length = 586

 Score =  233 bits (595), Expect = 2e-60
 Identities = 156/450 (34%), Positives = 239/450 (53%), Gaps = 9/450 (2%)
 Frame = +3

Query: 294  TKIVGTLGPNSHSVEVIEECLTAGMSVARFDFSWKDATYHQETLDNLRKAAQNVKKLCPI 473
            TKIV T+GP S S E++E+ + AGM+VAR +FS      H+  +D +RK A  + K   I
Sbjct: 4    TKIVCTIGPASESEEMLEKLMKAGMNVARLNFSHGSHEEHKARIDTIRKVADRLGKTIGI 63

Query: 474  MLDTVGPEIQVHNPTGGAIELIGGNHVTITPDLSKAPSADILPIKFGDLAKVVKKGDTLF 653
            +LDT GPEI+ H+   G I L  G  V ++    +  + +   + + DL   V+      
Sbjct: 64   LLDTKGPEIRTHDMKDGLIMLEKGKEVIVSMSQVEG-TPEKFSVTYEDLINDVQ------ 116

Query: 654  IGQYLFTGSETTSLWLEVMETSGEEVICFVKNTATLSGPIFTLHVSQVHISMPTLSEYDK 833
            +G Y+        L ++ ++ +  EV C + NT  L      +++  V +++P +++ D 
Sbjct: 117  VGSYILLDDGLVELQVKDIDKTKGEVKCDILNTGELKNKK-GVNLPGVKVNLPGITDKDA 175

Query: 834  QVISTWGLDNSVDIISLSHTRSSEDVRELRAFLQSHNLQDTQIYAKIENAEGLEHFDEIL 1013
              I  +G+   VD I+ S  R   DV ++R  L+  N  +  I+ KIEN EG+++ +EIL
Sbjct: 176  DDI-LFGIKEDVDYIAASFVRRPSDVLDIREILERENNHNITIFPKIENQEGIDNIEEIL 234

Query: 1014 QEADGIIISRGDLGIDLPPERVFMSQKTGIHKCNMAGKPVI-ITRVVDSMIDNLRPTRAE 1190
            + +DG++++RGD+G+++PPE V + QK  I KCN  GKPVI  T+++DSM  N R TRAE
Sbjct: 235  EVSDGLMVARGDMGVEIPPESVPIVQKDLIRKCNKLGKPVITATQMLDSMQRNPRATRAE 294

Query: 1191 ATDVANAVLDGTDGILLGAETLRGQYPVDAVSTVGRICAEAETV--YNQSLHFK------ 1346
            A+DVANA+ DGTD ++L  ET  G YP +AV T+  I   AE    Y + L  +      
Sbjct: 295  ASDVANAIYDGTDAVMLSGETAAGLYPEEAVKTMRNIAVSAEAAQDYKKLLSDRTKLVET 354

Query: 1347 KVVRHVGEPMAHEEXXXXXXXXXXXXXXXXXIVVFTFSGRAARLVAKYRPPMPVLAVVFP 1526
             +V  +G  +AH                   IV  T SG  A  ++KYRP   ++AV  P
Sbjct: 355  SLVNAIGVSVAH----------TALNLNVKAIVAATESGSTAVTISKYRPHSDIIAVT-P 403

Query: 1527 REGSDPSKWRSYGTTQARQCFSVRGVYPLM 1616
             E +            ARQ   V G YP++
Sbjct: 404  SEHT------------ARQLALVWGAYPVI 421

---

>O94122:KPYK_AGABI Pyruvate kinase - Agaricus bisporus (Common mushroom)|
          Length = 532

 Score =  233 bits (594), Expect = 2e-60
 Identities = 154/455 (33%), Positives = 234/455 (51%), Gaps = 6/455 (1%)
 Frame = +3

Query: 264  PAKPKVFPSLTKIVGTLGPNSHSVEVIEECLTAGMSVARFDFSWKDATYHQETLDNLRKA 443
            P +   +   T I+ T+GP  ++VE + +   AG+++ R +FS     YHQ  +DN R+ 
Sbjct: 25   PTETTKYHRKTAIIATIGPKINTVEKLTDVRLAGVNIVRMNFSHGTHEYHQSVIDNTRQM 84

Query: 444  AQNVKKLCP--IMLDTVGPEIQV-HNPTGGAIELIGGNHVTITPDLSKAPSAD--ILPIK 608
             +N     P  I LDT GPEI+      G    +  G+   +T D   +   D  +L + 
Sbjct: 85   IKNDPHGRPVAIALDTKGPEIRTGQTRDGNDYPIKAGDEFIVTTDPKYSDICDNKVLFVD 144

Query: 609  FGDLAKVVKKGDTLFIGQYLFTGSETTSLWLEVMETSGEEVICFVKNTATLSGPIFTLHV 788
            + +LA V   G  ++I   + +        L ++   G  +     N  TLS     +++
Sbjct: 145  YANLASVTAPGKLIYIDDGIIS--------LLILSIDGMNLHVRALNNGTLSSRK-GVNL 195

Query: 789  SQVHISMPTLSEYDKQVISTWGLDNSVDIISLSHTRSSEDVRELRAFLQSHNLQDTQIYA 968
             +  + +P LSE DK  +  +G+ N VD+I  S  R  EDVR++R  L        +I  
Sbjct: 196  PKTDVDLPPLSEKDKDDLR-FGIRNGVDMIFASFIRRGEDVRQIREVLGPDGAS-IKIIV 253

Query: 969  KIENAEGLEHFDEILQEADGIIISRGDLGIDLPPERVFMSQKTGIHKCNMAGKPVII-TR 1145
            KIEN +G+ +FDEIL+EADG++++RGDLGI++P  +VF++QK  I KCN+ GKPVI+ T+
Sbjct: 254  KIENEQGVANFDEILKEADGVMVARGDLGIEIPASQVFLAQKMMIAKCNIVGKPVIVATQ 313

Query: 1146 VVDSMIDNLRPTRAEATDVANAVLDGTDGILLGAETLRGQYPVDAVSTVGRICAEAETVY 1325
            +++SM  N RPTRAE +DVANAVLDG+D ++L  ET +G YPV +V  +   C  AET  
Sbjct: 314  MLESMTYNPRPTRAEVSDVANAVLDGSDCVMLSGETAKGSYPVQSVLMMAETCLLAETAI 373

Query: 1326 NQSLHFKKVVRHVGEPMAHEEXXXXXXXXXXXXXXXXXIVVFTFSGRAARLVAKYRPPMP 1505
                 +  +      P    E                 ++V + SG  ARLV+KYRP +P
Sbjct: 374  CYPPLYDDLRAVQARPTETAETVAIAAVAAAAEQDAKALLVLSTSGETARLVSKYRPKIP 433

Query: 1506 VLAVVFPREGSDPSKWRSYGTTQARQCFSVRGVYP 1610
            ++ V             +     ARQ    RG YP
Sbjct: 434  IITV-------------TRNEQTARQIHLHRGCYP 455

---

>Q6BS75:KPYK_DEBHA Pyruvate kinase - Debaryomyces hansenii (Yeast) (Torulaspora|
            hansenii)
          Length = 504

 Score =  233 bits (593), Expect = 3e-60
 Identities = 164/511 (32%), Positives = 270/511 (52%), Gaps = 17/511 (3%)
 Frame = +3

Query: 294  TKIVGTLGPNSHSVEVIEECLTAGMSVARFDFSWKDATYHQETLDNLRKAAQNVK-KLCP 470
            + I+GT+GP +++V+V+ +   AG+++ R +FS     YHQ  +DN +++ +  K +   
Sbjct: 25   SSIIGTIGPKTNNVDVLVKLRKAGLNIVRMNFSHGSYEYHQSVIDNAKQSEEIYKGRPLA 84

Query: 471  IMLDTVGPEIQVHNPTGGAIE-----LIGGNHVTITPDLSKAPSAD--ILPIKFGDLAKV 629
            I LDT GPEI+    TG  I+     ++  + +  T D + A   D  ++ I + ++ KV
Sbjct: 85   IALDTKGPEIR----TGTTIDDKDYPILPNHEMIFTTDEAYAKKCDDKVMFIDYKNITKV 140

Query: 630  VKKGDTLFIGQYLFTGSETTSLWLEVMETSGEEVICFVKNTATLSGPIFT---LHVSQVH 800
            ++ G  ++I   + +         EV++   ++ +   K  +  SG I +   +++    
Sbjct: 141  IEAGKIIYIDDGVVS--------FEVLQIVDDKTL---KVRSVNSGKICSHKGVNLPGTD 189

Query: 801  ISMPTLSEYDKQVISTWGLDNSVDIISLSHTRSSEDVRELRAFLQSHNLQDTQIYAKIEN 980
            + +P LSE DK  I  +G+ N V +I  S  R+ +D++E+R  L     +D QI AKIEN
Sbjct: 190  VDLPALSEKDKADIK-FGVKNGVHMIFASFIRTGDDIKEIRKVLGEEG-KDIQIIAKIEN 247

Query: 981  AEGLEHFDEILQEADGIIISRGDLGIDLPPERVFMSQKTGIHKCNMAGKPVI-ITRVVDS 1157
             +G+ +FDEIL E DG++++RGDLGI++P  +VF+ QK  I KCN+A KPVI  T++++S
Sbjct: 248  QQGVNNFDEILVETDGVMVARGDLGIEIPAPQVFVVQKQLIAKCNLAAKPVICATQMLES 307

Query: 1158 MIDNLRPTRAEATDVANAVLDGTDGILLGAETLRGQYPVDAVSTVGRICAEAE-TVYNQS 1334
            M  N RPTRAE +DV NA+LDG D ++L  ET +G YP +AVS +      AE  +  Q 
Sbjct: 308  MTYNPRPTRAEVSDVGNAILDGADCVMLSGETAKGNYPFEAVSMMHNTAIIAEKAIAYQP 367

Query: 1335 LHFKKVVRHVGEPMAHEEXXXXXXXXXXXXXXXXXIVVFTFSGRAARLVAKYRPPMPVLA 1514
            LH  ++      P    E                 IVV + SG  +RLV+KY+P +PV+ 
Sbjct: 368  LH-NEIRSLANRPTPTTETCAMASVSAAYEQDAKAIVVLSTSGFTSRLVSKYKPNVPVMM 426

Query: 1515 VVFPREGSDPSKWRSYGTTQARQCFSVRGVYPLMGSTDEAETGGLTKEAYGIKLALNYGR 1694
            V             +     AR C   RGVYP +      +      E   ++ A++   
Sbjct: 427  V-------------TRNHRAARYCHLYRGVYPFVYEKKTVDNWQEDVE-NRLRWAVSEAI 472

Query: 1695 SVGIIKPYDRVIIFE----KIGDSSVVKIIE 1775
             +GIIK  D ++  +      G S+ V++++
Sbjct: 473  DLGIIKKGDSIVTIQGWTRGSGHSNTVRVVQ 503

---

>Q46289:KPYK_CLOPE Pyruvate kinase - Clostridium perfringens|
          Length = 474

 Score =  232 bits (591), Expect = 5e-60
 Identities = 136/409 (33%), Positives = 226/409 (55%), Gaps = 1/409 (0%)
 Frame = +3

Query: 294  TKIVGTLGPNSHSVEVIEECLTAGMSVARFDFSWKDATYHQETLDNLRKAAQNVKKLCPI 473
            TK++ T+GP+S S E++ E +  GM+ AR +FS  D   H+E ++ +++  +  K    I
Sbjct: 4    TKMIFTIGPSSDSEEILREFIRIGMNAARLNFSHGDHASHKEKIELIKRLRKEEKSATAI 63

Query: 474  MLDTVGPEIQVHNPTGGAIELIGGNHVTITPDLSKAPSADILPIKFGDLAKVVKKGDTLF 653
            +LD  GP+I+ +N   G  EL  G+  T +             I + +L + +K G ++ 
Sbjct: 64   LLDIKGPKIRTYNFKNGEAELKNGDEFTFSCGDEILGDNTKCSISYKELYEDIKPGGSIL 123

Query: 654  IGQYLFTGSETTSLWLEVMETSGEEVICFVKNTATLSGPIFTLHVSQVHISMPTLSEYDK 833
            +   L        L  +V E  G ++IC V    T+      ++V  V I +P ++E D+
Sbjct: 124  VDDGL--------LEFKVKEVRGTDIICEVIEGGTIKDHK-GVNVPNVPIKLPAVTEKDR 174

Query: 834  QVISTWGLDNSVDIISLSHTRSSEDVRELRAFLQSHNLQDTQIYAKIENAEGLEHFDEIL 1013
              +  +G +  VD ++ S  R  EDV E+R  L SH  +D +I +KIE+ EG+++  EI+
Sbjct: 175  SDL-IFGCEMEVDFVAASFIRKPEDVLEVREILDSHGGKDIKIISKIESQEGVDNIKEII 233

Query: 1014 QEADGIIISRGDLGIDLPPERVFMSQKTGIHKCNMAGKPVI-ITRVVDSMIDNLRPTRAE 1190
            +  DG++++RGD+G+++P E V + QK  I KCN AGK VI  T+++DSMI N RPTRAE
Sbjct: 234  KVTDGVMVARGDMGVEIPIENVPIIQKNIIKKCNQAGKIVITATQMLDSMIRNPRPTRAE 293

Query: 1191 ATDVANAVLDGTDGILLGAETLRGQYPVDAVSTVGRICAEAETVYNQSLHFKKVVRHVGE 1370
            A+DV NA+ DGTD I+L  E+  G +P++A  T+ RI  +AE   + +   +++      
Sbjct: 294  ASDVCNAIFDGTDAIMLSGESASGSFPIEAAMTMSRIAKKAEANLDYNYLLRRLKDPNPN 353

Query: 1371 PMAHEEXXXXXXXXXXXXXXXXXIVVFTFSGRAARLVAKYRPPMPVLAV 1517
            P A  +                 IV  T +G  A++++KY+P  P++A+
Sbjct: 354  PDAFADAISYSASKTASKFPTKAIVAATQTGSTAKILSKYKPSCPIIAI 402

---

>P30614:KPYK_YARLI Pyruvate kinase - Yarrowia lipolytica (Candida lipolytica)|
          Length = 515

 Score =  231 bits (590), Expect = 7e-60
 Identities = 161/506 (31%), Positives = 261/506 (51%), Gaps = 11/506 (2%)
 Frame = +3

Query: 294  TKIVGTLGPNSHSVEVIEECLTAGMSVARFDFSWKDATYHQETLDNLRKAAQNVK-KLCP 470
            + I+GT+GPN++S E+I +   AG+++ R +FS     YHQ  ++N R++ Q  + +   
Sbjct: 32   SSIIGTIGPNTNSAEMISKLRQAGLNIVRMNFSHGSYEYHQSVIENARESEQQFQGRPLA 91

Query: 471  IMLDTVGPEIQVHNPTGGAIELIGGNHVTITPDLSKAPSADILPIKFGDLAKVVKKGDTL 650
            I LDT GPEI+           +   HV +     K        I + D   +VK+ D  
Sbjct: 92   IALDTKGPEIRTGVTKDDKDWDVKAGHVMLFSTNPKYKDQCDDKIMYIDYTNIVKQID-- 149

Query: 651  FIGQYLFTGSETTSLWLEVMET-SGEEVICFVKNTATLSGPIFTLHVSQVHISMPTLSEY 827
             IG+ +F      S   +V+E   GE +     N   +S     +++    + +P LSE 
Sbjct: 150  -IGKIIFVDDGVLSF--KVLEKIDGETLKVETLNNGKISSRK-GVNLPGTDVDLPALSEK 205

Query: 828  DKQVISTWGLDNSVDIISLSHTRSSEDVRELRAFLQSHNLQDTQIYAKIENAEGLEHFDE 1007
            DK  +  +G+++ VD+I  S  R++ DV+ +R  L     +  Q+ +KIEN +G+ +FDE
Sbjct: 206  DKADLK-FGVEHGVDMIFASFVRTANDVQAIRDVLGEKG-KGIQVISKIENQQGVNNFDE 263

Query: 1008 ILQEADGIIISRGDLGIDLPPERVFMSQKTGIHKCNMAGKPVI-ITRVVDSMIDNLRPTR 1184
            IL+E DG++++RGDLGI++P  +VF++QK  I KCN+AGKPVI  T+++DSM  N RPTR
Sbjct: 264  ILKETDGVMVARGDLGIEIPAPQVFIAQKQLIAKCNLAGKPVICATQMLDSMTYNPRPTR 323

Query: 1185 AEATDVANAVLDGTDGILLGAETLRGQYPVDAVSTVGRICAEAETVYNQSLHFKKVVRHV 1364
            AE +DV NAVLDG D ++L  ET +G YP+++V  +   C  AE     +  F ++    
Sbjct: 324  AEVSDVGNAVLDGADCVMLSGETAKGTYPIESVKMMHETCLVAEKAIAYAPLFNEMRTLT 383

Query: 1365 GEPMAHEEXXXXXXXXXXXXXXXXXIVVFTFSGRAARLVAKYRPPMPVLAVVFPREGSDP 1544
              P    E                 I+V + SG +ARL +KYRP  P+L V         
Sbjct: 384  VRPTETVETIAISAVSASFEQQARAIIVLSTSGTSARLCSKYRPNCPILMV--------- 434

Query: 1545 SKWRSYGTTQARQCFSVRGVYPLMGSTDEAETGGLTKEAYGIKLALNYGR----SVGIIK 1712
                +     AR     RGVYP +    +A      +  + ++  L +G     ++GI+ 
Sbjct: 435  ----TRNAQAARFSHLYRGVYPFI--YHKARASNPAEWQHDVEERLKWGMDEAVALGILN 488

Query: 1713 PYDRVIIFE----KIGDSSVVKIIEC 1778
              D V+  +     +G ++ ++++EC
Sbjct: 489  KGDVVVAIQGWTGGLGHTNTLRVLEC 514

---

>Q759A9:KPYK_ASHGO Pyruvate kinase - Ashbya gossypii (Yeast) (Eremothecium gossypii)|
          Length = 501

 Score =  229 bits (583), Expect = 5e-59
 Identities = 157/505 (31%), Positives = 259/505 (51%), Gaps = 12/505 (2%)
 Frame = +3

Query: 294  TKIVGTLGPNSHSVEVIEECLTAGMSVARFDFSWKDATYHQETLDNLRKAAQNVK-KLCP 470
            T I+GT+GP +++ E + E   AG+++ R +FS     YHQ  +DN RK+ +    +   
Sbjct: 22   TSIIGTIGPKTNNPETLVELRKAGLNIVRMNFSHGSYEYHQSVIDNARKSEELYPGRPLA 81

Query: 471  IMLDTVGPEIQVHNPTGGAIELIGGNHVTI-TPDLSKAPSAD--ILPIKFGDLAKVVKKG 641
            I LDT GPEI+           I  NH  I T D   A S D  ++ + + ++ KV++KG
Sbjct: 82   IALDTKGPEIRTGTTVDNVDYPIPPNHEMIFTTDDQYAKSCDDKVMFVDYKNITKVIEKG 141

Query: 642  DTLFIGQYLFTGSETTSLWLEVMETSGEEVICFVKNTATLSGPIFT---LHVSQVHISMP 812
              +++   + +         EV+E   ++ +   K  +  +G I +   +++    + +P
Sbjct: 142  RVIYVDDGVLS--------FEVLEVVDDKTL---KVKSLNAGKICSHKGVNLPGTDVDLP 190

Query: 813  TLSEYDKQVISTWGLDNSVDIISLSHTRSSEDVRELRAFLQSHNLQDTQIYAKIENAEGL 992
             LSE DK  +  +G+ N V ++  S  R++ D+  +R  L     +D +I AKIEN +G+
Sbjct: 191  ALSEKDKSDLR-FGVKNGVHMVFASFIRTAGDILTIREILGEDG-KDIKIIAKIENQQGV 248

Query: 993  EHFDEILQEADGIIISRGDLGIDLPPERVFMSQKTGIHKCNMAGKPVI-ITRVVDSMIDN 1169
             +FDEIL+  DG++++RGDLGI++P  +VF  QK  I KCN+AGKPVI  T++++SM  N
Sbjct: 249  NNFDEILKVTDGVMVARGDLGIEIPAPQVFAVQKMLIAKCNLAGKPVICATQMLESMTYN 308

Query: 1170 LRPTRAEATDVANAVLDGTDGILLGAETLRGQYPVDAVSTVGRICAEAETVYNQSLHFKK 1349
             RPTRAE +DV NAVLDG D ++L  ET +G YP++AV T+      AE        +  
Sbjct: 309  PRPTRAEVSDVGNAVLDGADCVMLSGETAKGIYPINAVKTMAETALIAEQAIPYVPTYDD 368

Query: 1350 VVRHVGEPMAHEEXXXXXXXXXXXXXXXXXIVVFTFSGRAARLVAKYRPPMPVLAVVFPR 1529
            +     +P    E                 IVV + SG   RLV+KY+P +P++ V    
Sbjct: 369  LRNLTPKPTPTSETIAAAAVAATFEQKAKAIVVLSTSGDTTRLVSKYKPNVPIVMV---- 424

Query: 1530 EGSDPSKWRSYGTTQARQCFSVRGVYPLMGSTDEAETGGLTKEAYGIKLALNYGRSVGII 1709
                     +     AR C   RGV+P +   + A+      EA  +   +   + +GI+
Sbjct: 425  ---------TRNPRAARYCHLHRGVFPFVYEQEAADEWTDDVEA-RLNFGVEKSKELGIL 474

Query: 1710 KPYDRVIIFE----KIGDSSVVKII 1772
               D ++  +     +G S+ ++++
Sbjct: 475  SEGDTIVTIQGFASGVGHSNTLRVL 499

---

>Q10208:KPYK_SCHPO Pyruvate kinase - Schizosaccharomyces pombe (Fission yeast)|
          Length = 509

 Score =  226 bits (577), Expect = 2e-58
 Identities = 161/491 (32%), Positives = 255/491 (51%), Gaps = 9/491 (1%)
 Frame = +3

Query: 294  TKIVGTLGPNSHSVEVIEECLTAGMSVARFDFSWKDATYHQETLDNLRKA-AQNVKKLCP 470
            T I+ T+GP S++VE + +   AGM++ R +FS     YHQ  +DN RKA A N      
Sbjct: 28   TSIICTIGPKSNNVETLCKLRDAGMNIVRMNFSHGSYEYHQSVIDNARKASATNPLFPLA 87

Query: 471  IMLDTVGPEIQVHNPTGGAIELIGGNHVTI-TPDLSKAPSAD--ILPIKFGDLAKVVKKG 641
            I LDT GPEI+     GG    I   H  I T D + A   +  ++ I + ++ KV++ G
Sbjct: 88   IALDTKGPEIRTGLTVGGTDYPISSGHEMIFTTDDAYAEKCNDKVMYIDYKNITKVIQPG 147

Query: 642  DTLFIGQYLFTGSETTSLWLEVMETSGEEVICFVKNTATLSGPIFTLHVSQVHISMPTLS 821
              +++   + +       +  + +   + +   V N   +S     +++ +  + +P LS
Sbjct: 148  RIIYVDDGILS-------FTVIEKVDDKNLKVRVNNNGKISSKK-GVNLPKTDVDLPALS 199

Query: 822  EYDKQVISTWGLDNSVDIISLSHTRSSEDVRELRAFLQSHNLQDTQIYAKIENAEGLEHF 1001
            E DK  +  +G+ N VD+I  S  R +EDV  +R  L     ++ +I  KIEN +G+ +F
Sbjct: 200  EKDKADLR-FGVKNGVDMIFASFIRRAEDVIHIREVLGEEG-KNIKIICKIENQQGVNNF 257

Query: 1002 DEILQEADGIIISRGDLGIDLPPERVFMSQKTGIHKCNMAGKPV-IITRVVDSMIDNLRP 1178
            D IL   DGI+++RGDLGI++P  +VF++QK  I KCN+AGKPV   T++++SM  N RP
Sbjct: 258  DSILDVTDGIMVARGDLGIEIPASQVFVAQKMMIAKCNIAGKPVACATQMLESMTYNPRP 317

Query: 1179 TRAEATDVANAVLDGTDGILLGAETLRGQYPVDAVSTVGRICAEAETVYNQSLHFKKVVR 1358
            TRAE +DV NAVLDG D ++L  ET +G YPV+AV+ +      AE        ++++  
Sbjct: 318  TRAEVSDVGNAVLDGADLVMLSGETTKGSYPVEAVTYMAETARVAEASIPYGSLYQEMFG 377

Query: 1359 HVGEPM-AHEEXXXXXXXXXXXXXXXXXIVVFTFSGRAARLVAKYRPPMPVLAVVFPREG 1535
             V  P+    E                 IVV + SG  ARL +KYRP +P++ V      
Sbjct: 378  LVRRPLECATETTAVAAIGASIESDAKAIVVLSTSGNTARLCSKYRPSIPIVMV------ 431

Query: 1536 SDPSKWRSYGTTQARQCFSVRGVYPLMGSTD---EAETGGLTKEAYGIKLALNYGRSVGI 1706
                   +    +ARQ    RGVYP++   +   + +     + AYG + A      + I
Sbjct: 432  -------TRCPQRARQSHLNRGVYPVIYEKEPLSDWQKDVDARVAYGCQQAY----KMNI 480

Query: 1707 IKPYDRVIIFE 1739
            +K  D++I+ +
Sbjct: 481  LKKGDKIIVLQ 491

---

>Q875S4:KPYK_SACKL Pyruvate kinase - Saccharomyces kluyveri (Yeast) (Saccharomyces|
            silvestris)
          Length = 501

 Score =  226 bits (576), Expect = 3e-58
 Identities = 157/510 (30%), Positives = 265/510 (51%), Gaps = 17/510 (3%)
 Frame = +3

Query: 294  TKIVGTLGPNSHSVEVIEECLTAGMSVARFDFSWKDATYHQETLDNLRKAAQNVK-KLCP 470
            T I+GT+GP +++ E +     AG+++ R +FS     YHQ  +DN RK+ +    +   
Sbjct: 22   TSIIGTIGPKTNNPETLVALRKAGLNIVRMNFSHGSYEYHQSVIDNARKSEELYPGRPLA 81

Query: 471  IMLDTVGPEIQVHNPTGGAIELIGGNH---VTITPDLSKAPSADILPIKFGDLAKVVKKG 641
            I LDT GPEI+    T      I  NH    +I    +KA    ++ I + ++ KV++KG
Sbjct: 82   IALDTKGPEIRTGTTTNEVDYPIPPNHEMIFSIDDKYAKACDDKVMYIDYKNITKVIEKG 141

Query: 642  DTLFIGQYLFTGSETTSLWLEVMETSGEEVICFVKNTATLSGPIFT---LHVSQVHISMP 812
              +++   + +         EV+E   E+ +   K  +  +G I +   +++    + +P
Sbjct: 142  KIIYVDDGVLS--------FEVLEVVDEQTL---KVKSLNAGKICSHKGVNLPGTDVDLP 190

Query: 813  TLSEYDKQVISTWGLDNSVDIISLSHTRSSEDVRELRAFLQSHNLQDTQIYAKIENAEGL 992
             LSE DK  +  +G+ N V ++  S  R+++DV  +R  L     +D +I  KIEN +G+
Sbjct: 191  ALSEKDKSDLR-FGVKNGVHMVFASFIRTAQDVLTIREVLGEDG-KDVKIIVKIENQQGV 248

Query: 993  EHFDEILQEADGIIISRGDLGIDLPPERVFMSQKTGIHKCNMAGKPVI-ITRVVDSMIDN 1169
             +FDEIL+  DG++++RGDLGI++P  +VF  QK  I KCN+AGKPVI  T++++SM  N
Sbjct: 249  NNFDEILKVTDGVMVARGDLGIEIPAPQVFAVQKKLIAKCNLAGKPVICATQMLESMTYN 308

Query: 1170 LRPTRAEATDVANAVLDGTDGILLGAETLRGQYPVDAVSTVGRICAEAETVYNQSLHFKK 1349
             RPTRAE +DV NAVLDG D ++L  ET +G YP++AV+ +      AE        +  
Sbjct: 309  PRPTRAEVSDVGNAVLDGADCVMLSGETAKGNYPINAVTIMAETALIAEQAIPYVATYDD 368

Query: 1350 VVRHVGEPMAHEEXXXXXXXXXXXXXXXXXIVVFTFSGRAARLVAKYRPPMPVLAVVFPR 1529
            +     +P +  E                 I+V + +G   RLV+KY+P +P++ V    
Sbjct: 369  LRNFTPKPTSTTETIAAAAVSSVFEQKAKAIIVLSTTGDTPRLVSKYKPNVPIVMV---- 424

Query: 1530 EGSDPSKWRSYGTTQARQCFSVRGVYPLMGSTD-EAETGGLTKEAYGIKLALNYG----R 1694
                     +     AR     RGV+P +  +D E+E    TK+   ++  LN+G    +
Sbjct: 425  ---------TRNPRAARFSHLYRGVFPFVYESDTESE---WTKD---VESRLNFGIAKAK 469

Query: 1695 SVGIIKPYDRVIIFE----KIGDSSVVKII 1772
              G++K  D ++  +     +G S+ ++++
Sbjct: 470  EFGMLKEGDTIVTIQGFAAGVGHSNTLRVL 499

---

>P34038:KPYK_LACDE Pyruvate kinase - Lactobacillus delbrueckii subsp. bulgaricus|
          Length = 589

 Score =  225 bits (574), Expect = 5e-58
 Identities = 161/500 (32%), Positives = 254/500 (50%), Gaps = 8/500 (1%)
 Frame = +3

Query: 294  TKIVGTLGPNSHSVEVIEECLTAGMSVARFDFSWKDATYHQETLDNLRKAAQNVKKLCPI 473
            TKIV TLGP S  +E I +   AG +V RF+FS  +   H   ++ +R+  +   KL  I
Sbjct: 4    TKIVSTLGPASDDIETITKLAEAGANVFRFNFSHGNHEEHLARMNMVREVEKKTGKLLGI 63

Query: 474  MLDTVGPEIQVHNPTGGAIELIGGNHVTITPDLSKAPSADILPIKFGDLAKVVKKGDTLF 653
             LDT G EI+  +  GG   +  G+ + ++ D +KA + D++ + +  L      G T+ 
Sbjct: 64   ALDTKGAEIRTTDQEGGKFTINTGDEIRVSMDATKAGNKDMIHVTYPGLFDDTHVGGTVL 123

Query: 654  IGQYLFTGSETTSLWLEVMETSGEEVICFVKNTATLSGPIFTLHVSQVHISMPTLSEYDK 833
            I            L ++  +    E++C  +NT  + G    ++   V I +P ++E D 
Sbjct: 124  IDD------GAVGLTIKAKDEEKRELVCEAQNTGVI-GSKKGVNAPGVEIRLPGITEKDT 176

Query: 834  QVISTWGLDNSVDIISLSHTRSSEDVRELRAFLQSHNLQDTQIYAKIENAEGLEHFDEIL 1013
              I  +GL + ++ I  S  R ++DV ++RA  +  N    +I+ KIE+ EG+++ DEIL
Sbjct: 177  DDIR-FGLKHGINFIFASFVRKAQDVLDIRALCEEANASYVKIFPKIESQEGIDNIDEIL 235

Query: 1014 QEADGIIISRGDLGIDLPPERVFMSQKTGIHKCNMAGKPVI-ITRVVDSMIDNLRPTRAE 1190
            Q +DG++++RGD+G+++P   V   QKT I KCN  GKPVI  T+++DSM +N RPTRAE
Sbjct: 236  QVSDGLMVARGDMGVEIPFINVPFVQKTLIKKCNALGKPVITATQMLDSMQENPRPTRAE 295

Query: 1191 ATDVANAVLDGTDGILLGAETLRGQYPVDAVSTVGRI--CAEAETVYNQSLHFKKVVRHV 1364
             TDVANAVLDGTD  +L  E+  G YPV +V  +  I    E E     +L  ++   + 
Sbjct: 296  VTDVANAVLDGTDATMLSGESANGLYPVQSVQAMHDIDVRTEKELDTRNTLALQRFEEYK 355

Query: 1365 GEPMAHEEXXXXXXXXXXXXXXXXXIVVFTFSGRAARLVAKYRPPMPVLAVVFPREGSDP 1544
            G  +   E                 I+  T SG  AR+++KYRP   ++A+ F     D 
Sbjct: 356  GSNVT--EAIGESVVRTAQELGVKTIIAATSSGYTARMISKYRPDATIVALTF-----DE 408

Query: 1545 SKWRSYGTTQARQCFSVRGVYPLMGSTDEAETGGLTKEAYGIKLALNYGRSVGIIKPYDR 1724
                S G         V GV P++     A+    T E +  + A    +  G +K  D 
Sbjct: 409  KIQHSLGI--------VWGVEPVL-----AKKPSNTDEMF--EEAARVAKEHGFVKDGDL 453

Query: 1725 VII-----FEKIGDSSVVKI 1769
            VII     F + G ++++K+
Sbjct: 454  VIIVAGVPFGQSGTTNLMKL 473

---

>Q6FV12:KPYK2_CANGA Pyruvate kinase 2 - Candida glabrata (Yeast) (Torulopsis glabrata)|
          Length = 508

 Score =  223 bits (567), Expect = 3e-57
 Identities = 156/504 (30%), Positives = 255/504 (50%), Gaps = 12/504 (2%)
 Frame = +3

Query: 294  TKIVGTLGPNSHSVEVIEECLTAGMSVARFDFSWKDATYHQETLDNLRKAAQNVK-KLCP 470
            T I+GT+GP +++V+ +     AG+++ R +FS     YHQ  +DN RK+ Q    +   
Sbjct: 22   TAIIGTIGPKTNNVDTLVALRKAGLNIVRMNFSHGSYEYHQSVIDNARKSEQVYPGRPLA 81

Query: 471  IMLDTVGPEIQVHNPTGGAIELIGGNHVTI-TPDLSKAPSAD--ILPIKFGDLAKVVKKG 641
            I LDT GPEI+           I  NH  I T D   A + D  I+ + + ++ KV++ G
Sbjct: 82   IALDTKGPEIRTGTNVDDVDYPIPPNHEMIFTTDDKYAKACDDKIMYVDYKNITKVIQPG 141

Query: 642  DTLFIGQYLFTGSETTSLWLEVMETSGEEVICFVKNTATLSGPIFTLHVSQVHISMPTLS 821
              +++   + +         EV+E   ++ +      A        +++    + +P LS
Sbjct: 142  KVIYVDDGVLS--------FEVLEVVDDKTLKVKSLNAGKISSHKGVNLPGTDVDLPALS 193

Query: 822  EYDKQVISTWGLDNSVDIISLSHTRSSEDVRELRAFLQSHNLQDTQIYAKIENAEGLEHF 1001
            E DK+ +  +G+ N V +I  S  R+++DV  +R  L     +D ++  KIEN +G+ +F
Sbjct: 194  EKDKEDLR-FGVKNGVHMIFASFIRTAQDVLTIREVLGEEG-KDIKVIVKIENQQGVNNF 251

Query: 1002 DEILQEADGIIISRGDLGIDLPPERVFMSQKTGIHKCNMAGKPVI-ITRVVDSMIDNLRP 1178
            DEIL+ A G++++RGDLGI++P  +V   QK  I KCN+AGKPVI  T++++SM  N RP
Sbjct: 252  DEILEVAHGVMVARGDLGIEIPAPQVLAVQKKLIAKCNLAGKPVICATQMLESMTFNPRP 311

Query: 1179 TRAEATDVANAVLDGTDGILLGAETLRGQYPVDAVSTVGRICAEAETVYNQSLHFKKVVR 1358
            TRAE +DV NA+LDG D ++L  ET +G YP++AV+T+      AE        +  +  
Sbjct: 312  TRAEVSDVGNAILDGADCVMLSGETAKGNYPINAVTTMAETAIIAERAIAYMPLYDDLRN 371

Query: 1359 HVGEPMAHEEXXXXXXXXXXXXXXXXXIVVFTFSGRAARLVAKYRPPMPVLAVVFPREGS 1538
               +P +  E                 I+V + SG  ARLV+KYRP  P++ V       
Sbjct: 372  CTPKPTSTTETVAASAVAAVQEQGAKLILVLSTSGNTARLVSKYRPQCPIVLVT------ 425

Query: 1539 DPSKWRSYGTTQARQCFSVRGVYPLMGSTDEAETGGLTKEA---YGIKLALNYGRSVGII 1709
                 R+  T +    F  RGV+P +   +  +       A   +G+ +A  Y    G +
Sbjct: 426  -----RNPRTARFSHLF--RGVFPFVYEKEPLDDWSEDTHARLRFGVDMAKEY----GFV 474

Query: 1710 KPYDRVIIFE----KIGDSSVVKI 1769
            K  D VI  +     +G S+ +++
Sbjct: 475  KNGDAVISIQGFKGGVGHSNTMRV 498

---

>Q875M9:KPYK_KLULA Pyruvate kinase - Kluyveromyces lactis (Yeast) (Candida sphaerica)|
          Length = 501

 Score =  219 bits (559), Expect = 3e-56
 Identities = 156/508 (30%), Positives = 261/508 (51%), Gaps = 15/508 (2%)
 Frame = +3

Query: 294  TKIVGTLGPNSHSVEVIEECLTAGMSVARFDFSWKDATYHQETLDNLRKAAQNVK-KLCP 470
            T I+ T+GP +++ E + E   AGM++ R +FS     YHQ  +DN RK+ +  + +   
Sbjct: 22   TSIICTIGPKTNNPETLVELRKAGMNIVRMNFSHGSYEYHQSVIDNARKSEELYQGRPLA 81

Query: 471  IMLDTVGPEIQVHNPTGGAIELIGGNHVTI-TPDLSKAPSAD--ILPIKFGDLAKVVKKG 641
            I LDT GPEI+    T      I  NH  I T D   A + D   + + + ++ KV++ G
Sbjct: 82   IALDTKGPEIRTGTTTNDVDYPIPPNHEMIFTTDDKYAKACDDKTMYVDYKNITKVIEAG 141

Query: 642  DTLFIGQYLFTGSETTSLWLEVMETSGEEVICFVKNTATLSGPIFT---LHVSQVHISMP 812
              +++   + +         EV+E   +  +   K  +  +G I +   +++    + +P
Sbjct: 142  RIIYVDDGVLS--------FEVLEVIDDNTL---KVKSLNAGKICSHKGVNLPGTDVDLP 190

Query: 813  TLSEYDKQVISTWGLDNSVDIISLSHTRSSEDVRELRAFLQSHNLQDTQIYAKIENAEGL 992
             LSE DK  +  +G+ N V ++  S  R+++DV  +R  L     +D +I  KIEN +G+
Sbjct: 191  ALSEKDKSDLK-FGVKNGVHMVFASFIRTAQDVLTIREVLGEQG-KDIKIIVKIENQQGV 248

Query: 993  EHFDEILQEADGIIISRGDLGIDLPPERVFMSQKTGIHKCNMAGKPVI-ITRVVDSMIDN 1169
             +FD+IL+  DG++++RGDLGI++P  +VF  QK  I KCN+AGKPVI  T++++SM  N
Sbjct: 249  NNFDDILKVTDGVMVARGDLGIEIPAPQVFAVQKKLIAKCNLAGKPVICATQMLESMTYN 308

Query: 1170 LRPTRAEATDVANAVLDGTDGILLGAETLRGQYPVDAVSTVGRICAEAETVYNQSLHFKK 1349
             RPTRAE +DV NAVLDG D ++L  ET +G YP++AV T+      AE        +  
Sbjct: 309  PRPTRAEVSDVGNAVLDGADCVMLSGETAKGNYPINAVKTMAETALIAEQAIPYIPTYDD 368

Query: 1350 VVRHVGEPMAHEEXXXXXXXXXXXXXXXXXIVVFTFSGRAARLVAKYRPPMPVLAVVFPR 1529
            +     +P +  E                 ++V + +G   RLVAKY+P +P++ V    
Sbjct: 369  LRNLTPKPTSTTETIAAASVSAVFEQKARALIVLSTTGDTPRLVAKYKPNVPIVMV---- 424

Query: 1530 EGSDPSKWRSYGTTQARQCFSVRGVYPLM--GSTDEAETGGLTKEA-YGIKLALNYGRSV 1700
                     +     AR     RGV+P +   S+D   T  + K   +G+K A    +  
Sbjct: 425  ---------TRNPRAARFSHLYRGVFPFVYDESSDSEWTVDVEKRINFGVKKA----KEF 471

Query: 1701 GIIKPYDRVIIFE----KIGDSSVVKII 1772
            GI+   D ++  +     +G+S+ ++++
Sbjct: 472  GILVDGDTIVTIQGFAAGVGNSNTLRVL 499

---

>P52489:KPYK2_YEAST Pyruvate kinase 2 - Saccharomyces cerevisiae (Baker's yeast)|
          Length = 506

 Score =  218 bits (555), Expect = 8e-56
 Identities = 161/504 (31%), Positives = 253/504 (50%), Gaps = 12/504 (2%)
 Frame = +3

Query: 294  TKIVGTLGPNSHSVEVIEECLTAGMSVARFDFSWKDATYHQETLDNLRKAAQNVK-KLCP 470
            T I+GT+GP ++S E I     AG+++ R +FS     +HQ  ++N  K+ Q    +   
Sbjct: 23   TSIIGTIGPKTNSCEAITALRKAGLNIIRLNFSHGSYEFHQSVIENAVKSEQQFPGRPLA 82

Query: 471  IMLDTVGPEIQVHNPTGGAIELIGGNHVTI-TPDLSKAPSAD--ILPIKFGDLAKVVKKG 641
            I LDT GPEI+           I  +H  I T D S A +++  I+ I + +L KV+  G
Sbjct: 83   IALDTKGPEIRTGRTLNDQDLYIPVDHQMIFTTDASFANTSNDKIMYIDYANLTKVIVPG 142

Query: 642  DTLFIGQYLFTGSETTSLWLEVMETSGEEVICFVKNTATLSGPIFT---LHVSQVHISMP 812
              +++   + +        L++++ S   V       A  SG I +   +++    + +P
Sbjct: 143  RFIYVDDGILSFKV-----LQIIDESNLRV------QAVNSGYIASHKGVNLPNTDVDLP 191

Query: 813  TLSEYDKQVISTWGLDNSVDIISLSHTRSSEDVRELRAFLQSHNLQDTQIYAKIENAEGL 992
             LS  D + +  +G+ N + I+  S  R+SEDV  +R  L S   QD +I +KIEN +GL
Sbjct: 192  PLSAKDMKDLQ-FGVRNGIHIVFASFIRTSEDVLSIRKALGSEG-QDIKIISKIENQQGL 249

Query: 993  EHFDEILQEADGIIISRGDLGIDLPPERVFMSQKTGIHKCNMAGKPVI-ITRVVDSMIDN 1169
            ++FDEIL+  DG++I+RGDLGI++    V   QK  I KCN+AGKPVI  T+++DSM  N
Sbjct: 250  DNFDEILEVTDGVMIARGDLGIEILAPEVLAIQKKLIAKCNLAGKPVICATQMLDSMTHN 309

Query: 1170 LRPTRAEATDVANAVLDGTDGILLGAETLRGQYPVDAVSTVGRICAEAETVYNQSLHFKK 1349
             RPTRAE +DV NAVLDG D ++L  ET +G YPV+AV+ +      AE+       +  
Sbjct: 310  PRPTRAEVSDVGNAVLDGADCVMLSGETAKGDYPVNAVNIMAATALIAESTIAHLALYDD 369

Query: 1350 VVRHVGEPMAHEEXXXXXXXXXXXXXXXXXIVVFTFSGRAARLVAKYRPPMPVLAVVFPR 1529
            +     +P +  E                 IVV + +G  ARL++KYRP  P++ V    
Sbjct: 370  LRDATPKPTSTTETVAAAATAAILEQDGKAIVVLSTTGNTARLLSKYRPSCPIILV---- 425

Query: 1530 EGSDPSKWRSYGTTQARQCFSVRGVYPLMGSTDEAETGGLTKEAYGIKLALNYGRSVGII 1709
                     +     AR     RGV+P +      +  G       +K  +   RS G++
Sbjct: 426  ---------TRHARTARIAHLYRGVFPFLYEPKRLDDWGEDVHR-RLKFGVEMARSFGMV 475

Query: 1710 KPYDRVIIFE----KIGDSSVVKI 1769
               D V+  +     +G S+ ++I
Sbjct: 476  DNGDTVVSIQGFKGGVGHSNTLRI 499

---

>Q6FIS9:KPYK1_CANGA Pyruvate kinase 1 - Candida glabrata (Yeast) (Torulopsis glabrata)|
          Length = 501

 Score =  214 bits (546), Expect = 9e-55
 Identities = 150/477 (31%), Positives = 243/477 (50%), Gaps = 11/477 (2%)
 Frame = +3

Query: 294  TKIVGTLGPNSHSVEVIEECLTAGMSVARFDFSWKDATYHQETLDNLRKAAQNVK-KLCP 470
            T I+GT+GP +++ E +     AG+++ R +FS     YH+  +DN RK+ +    +   
Sbjct: 22   TSIIGTIGPKTNNPETLVALRKAGLNIVRMNFSHGSYEYHKSVIDNARKSEELYPGRPLA 81

Query: 471  IMLDTVGPEIQVHNPTGGAIELIGGNHVTI-TPDLSKAPSAD--ILPIKFGDLAKVVKKG 641
            I LDT GPEI+    T      I  NH  I T D   A + D  I+ + + ++ KV+  G
Sbjct: 82   IALDTKGPEIRTGTTTNEVDYPIPPNHEMIFTTDDKYAKACDDKIMYLDYKNITKVISAG 141

Query: 642  DTLFIGQYLFTGSETTSLWLEVMETSGEEVICFVKNTATLSGPIFT---LHVSQVHISMP 812
              +++   + +         EV++   ++ +   K  +  +G I +   +++    + +P
Sbjct: 142  RIIYVDDGVLS--------FEVLQVVDDKTL---KVKSLNAGKICSHKGVNLPGTDVDLP 190

Query: 813  TLSEYDKQVISTWGLDNSVDIISLSHTRSSEDVRELRAFLQSHNLQDTQIYAKIENAEGL 992
             LSE DK  +  +G++N V +I  S  R+++DV  +R  L     +D +I  KIEN +G+
Sbjct: 191  ALSEKDKADLR-FGVENGVHMIFASFIRTAQDVLTIREVLGEDG-KDIKIVVKIENQQGV 248

Query: 993  EHFDEILQEADGIIISRGDLGIDLPPERVFMSQKTGIHKCNMAGKPVI-ITRVVDSMIDN 1169
             +FDEIL+  D ++++RGDLGI++P   V   QK  I K N+AGKPVI  T++++SM  N
Sbjct: 249  NNFDEILKVTDAVMVARGDLGIEIPAPEVLAVQKKLIAKSNLAGKPVICATQMLESMTYN 308

Query: 1170 LRPTRAEATDVANAVLDGTDGILLGAETLRGQYPVDAVSTVGRICAEAETVYNQSLHFKK 1349
             RPTRAE +DV NAVLDG D ++L  ET +G YP++AV+T+      AE       ++  
Sbjct: 309  PRPTRAEVSDVGNAVLDGADCVMLSGETAKGNYPINAVTTMAETALIAEQAIAYLPNYDD 368

Query: 1350 VVRHVGEPMAHEEXXXXXXXXXXXXXXXXXIVVFTFSGRAARLVAKYRPPMPVLAVVFPR 1529
            +     +P +  E                 I+V + SG  ARLV+KYRP  P++ V    
Sbjct: 369  IRNCTPKPTSTTETVAASAVAAVFEQKAKAIIVLSTSGTTARLVSKYRPNCPIILV---- 424

Query: 1530 EGSDPSKWRSYGTTQARQCFSVRGVYPLMGSTDEAETGGLTKEA---YGIKLALNYG 1691
                     +     AR     RGV+P +   +         EA   +GI+ A+ +G
Sbjct: 425  ---------TRNARTARFSHLYRGVFPFVYEKESVSDWTEDVEARLNFGIEQAIEFG 472

---

>P00549:KPYK1_YEAST Pyruvate kinase 1 - Saccharomyces cerevisiae (Baker's yeast)|
          Length = 500

 Score =  214 bits (544), Expect = 2e-54
 Identities = 152/488 (31%), Positives = 244/488 (50%), Gaps = 9/488 (1%)
 Frame = +3

Query: 294  TKIVGTLGPNSHSVEVIEECLTAGMSVARFDFSWKDATYHQETLDNLRKAAQNVK-KLCP 470
            T I+GT+GP +++ E +     AG+++ R +FS     YH+  +DN RK+ +    +   
Sbjct: 21   TSIIGTIGPKTNNPETLVALRKAGLNIVRMNFSHGSYEYHKSVIDNARKSEELYPGRPLA 80

Query: 471  IMLDTVGPEIQVHNPTGGAIELIGGNHVTI-TPDLSKAPSAD--ILPIKFGDLAKVVKKG 641
            I LDT GPEI+    T      I  NH  I T D   A + D  I+ + + ++ KV+  G
Sbjct: 81   IALDTKGPEIRTGTTTNDVDYPIPPNHEMIFTTDDKYAKACDDKIMYVDYKNITKVISAG 140

Query: 642  DTLFIGQYLFTGSETTSLWLEVMETSGEEVICFVKNTATLSGPIFT---LHVSQVHISMP 812
              +++   + +         +V+E   ++ +   K  A  +G I +   +++    + +P
Sbjct: 141  RIIYVDDGVLS--------FQVLEVVDDKTL---KVKALNAGKICSHKGVNLPGTDVDLP 189

Query: 813  TLSEYDKQVISTWGLDNSVDIISLSHTRSSEDVRELRAFLQSHNLQDTQIYAKIENAEGL 992
             LSE DK+ +  +G+ N V ++  S  R++ DV  +R  L     +D +I  KIEN +G+
Sbjct: 190  ALSEKDKEDLR-FGVKNGVHMVFASFIRTANDVLTIREVLGEQG-KDVKIIVKIENQQGV 247

Query: 993  EHFDEILQEADGIIISRGDLGIDLPPERVFMSQKTGIHKCNMAGKPVI-ITRVVDSMIDN 1169
             +FDEIL+  DG++++RGDLGI++P   V   QK  I K N+AGKPVI  T++++SM  N
Sbjct: 248  NNFDEILKVTDGVMVARGDLGIEIPAPEVLAVQKKLIAKSNLAGKPVICATQMLESMTYN 307

Query: 1170 LRPTRAEATDVANAVLDGTDGILLGAETLRGQYPVDAVSTVGRICAEAETVYNQSLHFKK 1349
             RPTRAE +DV NA+LDG D ++L  ET +G YP++AV+T+      AE       ++  
Sbjct: 308  PRPTRAEVSDVGNAILDGADCVMLSGETAKGNYPINAVTTMAETAVIAEQAIAYLPNYDD 367

Query: 1350 VVRHVGEPMAHEEXXXXXXXXXXXXXXXXXIVVFTFSGRAARLVAKYRPPMPVLAVV-FP 1526
            +     +P +  E                 I+V + SG   RLV+KYRP  P++ V   P
Sbjct: 368  MRNCTPKPTSTTETVAASAVAAVFEQKAKAIIVLSTSGTTPRLVSKYRPNCPIILVTRCP 427

Query: 1527 REGSDPSKWRSYGTTQARQCFSVRGVYPLMGSTDEAETGGLTKEAYGIKLALNYGRSVGI 1706
            R               AR     RGV+P +   +         EA  I   +   +  GI
Sbjct: 428  R--------------AARFSHLYRGVFPFVFEKEPVSDWTDDVEA-RINFGIEKAKEFGI 472

Query: 1707 IKPYDRVI 1730
            +K  D  +
Sbjct: 473  LKKGDTYV 480

---

>Q875Z9:KPYK_SACCA Pyruvate kinase - Saccharomyces castellii (Yeast)|
          Length = 501

 Score =  211 bits (538), Expect = 8e-54
 Identities = 148/477 (31%), Positives = 238/477 (49%), Gaps = 11/477 (2%)
 Frame = +3

Query: 294  TKIVGTLGPNSHSVEVIEECLTAGMSVARFDFSWKDATYHQETLDNLRKAAQNVK-KLCP 470
            T I+GT+GP +++ EV+     AG+++ R +FS     YHQ  ++N RK+ +    +   
Sbjct: 22   TSIIGTIGPKTNNPEVLVALRKAGLNIVRMNFSHGSYEYHQSVIENARKSEELYPGRPLA 81

Query: 471  IMLDTVGPEIQVHNPTGGAIELIGGNHVTI---TPDLSKAPSADILPIKFGDLAKVVKKG 641
            I LDT GPEI+    TG     I  NH  I       +KA    ++ + + ++ KV+ KG
Sbjct: 82   IALDTKGPEIRTGTTTGEVDYPIPPNHEMIFSTDEKYAKACDDKVMFVDYANITKVISKG 141

Query: 642  DTLFIGQYLFTGSETTSLWLEVMETSGEEVICFVKNTATLSGPIFT---LHVSQVHISMP 812
              +++   + +         EV+E    + +   K  +  +G I +   +++    + +P
Sbjct: 142  KIIYVDDGVLS--------FEVLEVVDGKTL---KVKSLNAGKICSHKGVNLPGTDVDLP 190

Query: 813  TLSEYDKQVISTWGLDNSVDIISLSHTRSSEDVRELRAFLQSHNLQDTQIYAKIENAEGL 992
             LSE DK  +  +G+ N V ++  S  R+++DV  +R  L     +D +I  KIEN +G+
Sbjct: 191  ALSEKDKADLR-FGVKNGVHMVFASFIRTAQDVLTIREVLGEDG-KDIKIVVKIENQQGV 248

Query: 993  EHFDEILQEADGIIISRGDLGIDLPPERVFMSQKTGIHKCNMAGKPVI-ITRVVDSMIDN 1169
             +FDEIL+  D ++++RGDLGI++P   V   QK  I K N+AGKPVI  T++++SM  N
Sbjct: 249  NNFDEILKVTDAVMVARGDLGIEIPAPEVLAVQKKLIAKSNLAGKPVICATQMLESMTYN 308

Query: 1170 LRPTRAEATDVANAVLDGTDGILLGAETLRGQYPVDAVSTVGRICAEAETVYNQSLHFKK 1349
             RPTRAE +DV NA+LDG D ++L  ET +G YP++AV+T+      AE        +  
Sbjct: 309  PRPTRAEVSDVGNAILDGADCVMLSGETAKGNYPINAVTTMADTALIAEQAIAYQPLYDD 368

Query: 1350 VVRHVGEPMAHEEXXXXXXXXXXXXXXXXXIVVFTFSGRAARLVAKYRPPMPVLAVVFPR 1529
            +     +P +  E                 I+V + SG   RLV+KYRP  P++ V    
Sbjct: 369  LRNLTPKPTSTTETVAASAVAAVYEQKAKAIIVLSTSGTTPRLVSKYRPDCPIILV---- 424

Query: 1530 EGSDPSKWRSYGTTQARQCFSVRGVYPLMGSTDEAETGGLTKE---AYGIKLALNYG 1691
                     +     AR     RGV+P +   D         E    +GI+ A+  G
Sbjct: 425  ---------TRNPRAARFSHLSRGVFPFVYEADSVADWTEDVELRLKFGIEKAIEMG 472

---

>Q55863:KPYK1_SYNY3 Pyruvate kinase 1 - Synechocystis sp. (strain PCC 6803)|
          Length = 483

 Score =  209 bits (532), Expect = 4e-53
 Identities = 139/408 (34%), Positives = 213/408 (52%), Gaps = 1/408 (0%)
 Frame = +3

Query: 294  TKIVGTLGPNSHSVEVIEECLTAGMSVARFDFSWKDATYHQETLDNLRKAAQNVKKLCPI 473
            TKIV T+GP S SVEVI + + AGM+VAR +FS      H   +  LR   Q +     +
Sbjct: 18   TKIVATIGPASSSVEVIRQMVDAGMNVARLNFSHGSYEDHATMVRLLRSVEQEMDTPITL 77

Query: 474  MLDTVGPEIQVHNPTGGAIELIGGNHVTITPDLSKAPSADILPIKFGDLAKVVKKGDTLF 653
            + D  GP+I++    GG  +L  G  V++ P          + I +  LA   K G+ + 
Sbjct: 78   LQDLQGPKIRIGQLPGGEKQLREGEKVSLVPVEIGDRHPGAVGIDYPHLATEAKVGERIL 137

Query: 654  IGQYLFTGSETTSLWLEVMETSGEEVICFVKNTATLSGPIFTLHVSQVHISMPTLSEYDK 833
            +   L        L ++V+     EVIC V     L      +++  + +++P+++  DK
Sbjct: 138  LDDGL--------LEMKVVSIQDPEVICEVVTGGILKSRK-GVNLPGLVLTLPSMTTKDK 188

Query: 834  QVISTWGLDNSVDIISLSHTRSSEDVRELRAFLQSHNLQDTQIYAKIENAEGLEHFDEIL 1013
            Q +  +GL   +D +SLS  R  ED+  L+ FL      D  + AKIE  + +++ +EI+
Sbjct: 189  QDLE-FGLSQGIDWVSLSFVRKGEDIHTLKQFLAERGHPDLPVIAKIEKPQAIDNLEEIV 247

Query: 1014 QEADGIIISRGDLGIDLPPERVFMSQKTGIHKCNMAGKPVI-ITRVVDSMIDNLRPTRAE 1190
              ++GI+++RGDLG+++ PE+V   QK  I +CN+   PVI  T+++DSMI N RPTRAE
Sbjct: 248  AVSNGIMVARGDLGVEVNPEKVPRLQKEIIRRCNVRAIPVITATQMLDSMIQNSRPTRAE 307

Query: 1191 ATDVANAVLDGTDGILLGAETLRGQYPVDAVSTVGRICAEAETVYNQSLHFKKVVRHVGE 1370
            A+DVANA+LDGTD ++L  E+  GQYPV +V  + +I  E E      LH   +V +   
Sbjct: 308  ASDVANAILDGTDAVMLSGESAVGQYPVKSVQMLRKIAEETEV----GLH---LVNNPPI 360

Query: 1371 PMAHEEXXXXXXXXXXXXXXXXXIVVFTFSGRAARLVAKYRPPMPVLA 1514
                                   IV FT SG  + L +  RP +PV+A
Sbjct: 361  ENTETHALSEALVVIDGILDLKYIVTFTTSGFTSLLASNQRPSVPVIA 408

---

>Q9WY51:KPYK_THEMA Pyruvate kinase - Thermotoga maritima|
          Length = 466

 Score =  188 bits (477), Expect = 9e-47
 Identities = 145/508 (28%), Positives = 257/508 (50%), Gaps = 12/508 (2%)
 Frame = +3

Query: 294  TKIVGTLGPNSHSVEVIEECLTAGMSVARFDFSWKDATYHQETLDNLRKAAQNVKKLCPI 473
            TKIV T+GP + S E+IE+ +  G++V R + S  D    ++ +  ++   +  KK   I
Sbjct: 4    TKIVCTVGPRTDSYEMIEKMIDLGVNVFRINTSHGDWNEQEQKILKIKDLREKKKKPVAI 63

Query: 474  MLDTVGPEIQVHNPTGGAIELIGGNHVTITPDLSKAPSADILPIKFGDLAKVVKKGDTLF 653
            ++D  GP+I+        +EL  G   T+T       +  I+ +    L K VKKGDT+ 
Sbjct: 64   LIDLAGPKIRTGYLEKEFVELKEGQIFTLTTK-EILGNEHIVSVNLSSLPKDVKKGDTIL 122

Query: 654  IGQYLFTGSETTSLWLEVMETSGEEVICFVKNTATLSGPIFT---LHVSQVHISMPTLSE 824
            +            + LEV+ET+  EV   VK    + G I     ++V    +S+ ++++
Sbjct: 123  LSD--------GEIVLEVIETTDTEVKTVVK----VGGKITHRRGVNVPTADLSVESITD 170

Query: 825  YDKQVISTWGLDNSVDIISLSHTRSSEDVRELRAFLQSHNLQDTQIYAKIENAEGLEHFD 1004
             D++ I   G  + V+  +LS  R  EDV + +  ++ H  ++  + +KIE  + LE  +
Sbjct: 171  RDREFIKL-GTLHDVEFFALSFVRKPEDVLKAKEEIRKHG-KEIPVISKIETKKALERLE 228

Query: 1005 EILQEADGIIISRGDLGIDLPPERVFMSQKTGIHKCNMAGKPVII-TRVVDSMIDNLRPT 1181
            EI++ +DGI+++RGDLG+++P E V + QK  I       KPVI+ T++++SMI+N  PT
Sbjct: 229  EIIKVSDGIMVARGDLGVEIPIEEVPIVQKEIIKLSKYYSKPVIVATQILESMIENPFPT 288

Query: 1182 RAEATDVANAVLDGTDGILLGAETLRGQYPVDAVSTVGRICAEAETVYNQSLHFKKVVRH 1361
            RAE TD+ANA+ DG D +LL AET  G++P++A+  + ++  EAE    + L F + + +
Sbjct: 289  RAEVTDIANAIFDGADALLLTAETAVGKHPLEAIKVLSKVAKEAE----KKLEFFRTIEY 344

Query: 1362 ----VGEPMAHEEXXXXXXXXXXXXXXXXXIVVFTFSGRAARLVAKYRPPMPVLAVVFPR 1529
                + E ++H                   I+  T SG  A  V+KY    P++A+  P 
Sbjct: 345  DTSDISEAISH------ACWQLSESLNAKLIITPTISGSTAVRVSKYNVSQPIVALT-PE 397

Query: 1530 EGSDPSKWRSYGTTQARQCFSVRGVYPLMGSTDEAETGGLTKEAYGIKLALNYGRSVGII 1709
            E       ++Y      +   VR V P++           ++E   I+  L     +G+ 
Sbjct: 398  E-------KTY-----YRLSLVRKVIPVLAEK-------CSQELEFIEKGLKKVEEMGLA 438

Query: 1710 KPYDRVIIFE----KIGDSSVVKIIECD 1781
            +  D V++      K+G ++ +++++ D
Sbjct: 439  EKGDLVVLTSGVPGKVGTTNTIRVLKVD 466

---

>P73534:KPYK2_SYNY3 Pyruvate kinase 2 - Synechocystis sp. (strain PCC 6803)|
          Length = 591

 Score =  187 bits (476), Expect = 1e-46
 Identities = 131/415 (31%), Positives = 222/415 (53%), Gaps = 4/415 (0%)
 Frame = +3

Query: 285  PSLTKIVGTLGPNSHSVEVIEECLTAGMSVARFDFSWKDATYHQETLDNLRKAAQNVKKL 464
            P  TKIV T+GP + S EV+ + + AG +  R +FS  D  YHQ+++  +R+ A  + + 
Sbjct: 7    PRRTKIVATIGPATQSKEVLRQLIQAGATTFRLNFSHGDHAYHQQSIRLIRQIAFELNQP 66

Query: 465  CPIMLDTVGPEIQVHN--PTGGAIELIGGNHVTITPDLSKAPSADILPIKFGDLAKVVKK 638
              I+ D  GP+I+V       G+++L  G+  T+T    +     I  I +  LA  V  
Sbjct: 67   VGILQDLQGPKIRVGKFLNDAGSVQLKNGDPYTLTSRPVECTET-ISSISYEYLADEVPS 125

Query: 639  GDTLFIGQYLFTGSETTSLWLEVMETSGEEVICFVKNTATLSGPIFTLHVSQVHISMPTL 818
            G  + +            + +E ++T   ++ C V    TLS     ++   V +S+  +
Sbjct: 126  GARILLDD------GKLEMLVEEVDTVARDLHCRVIVGGTLSSNK-GVNFPGVCLSVKAM 178

Query: 819  SEYDKQVISTWGLDNSVDIISLSHTRSSEDVRELRAFLQSHNLQDTQIYAKIENAEGLEH 998
            ++ DK+ +  +GLD  VD ++LS  R+ +D+ E++  + +   +   + AKIE  E ++ 
Sbjct: 179  TDKDKEDLM-FGLDQGVDWVALSFVRNPQDIDEIKGLIAAAG-KSVPVIAKIEKHEAIKD 236

Query: 999  FDEILQEADGIIISRGDLGIDLPPERVFMSQKTGIHKCNMAGKPVII-TRVVDSMIDNLR 1175
               +L++ DG++++RGDLG++LP E V + QK  I   N  G PVI  T+++DSM+++ R
Sbjct: 237  MQAVLEKCDGVMVARGDLGVELPAEDVPILQKKLIATANRLGIPVITATQMLDSMVNSPR 296

Query: 1176 PTRAEATDVANAVLDGTDGILLGAETLRGQYPVDAVSTVGRICAEAETVYNQSLHFKKV- 1352
            PTRAE +DVANA+LDGTD ++L  ET  G++PV+AV+ + +I   AE +  + ++  +  
Sbjct: 297  PTRAEVSDVANAILDGTDAVMLSNETAIGKFPVEAVAIMAKI---AERIEQEDINPSQAE 353

Query: 1353 VRHVGEPMAHEEXXXXXXXXXXXXXXXXXIVVFTFSGRAARLVAKYRPPMPVLAV 1517
                  P A                    I+  T +G  AR V+K+RP  P+LAV
Sbjct: 354  ASRTSIPNA----ISSAVSQIAETLNAAAIMSLTKTGSTARHVSKFRPKTPILAV 404

---

>P94939:KPYK_MYCIT Pyruvate kinase - Mycobacterium intracellulare|
          Length = 472

 Score =  183 bits (465), Expect = 2e-45
 Identities = 138/413 (33%), Positives = 209/413 (50%), Gaps = 7/413 (1%)
 Frame = +3

Query: 297  KIVGTLGPNSHSVEVIEECLTAGMSVARFDFSWKDATYHQETLDNLRKAAQNVKKLCPIM 476
            KIV TLGP ++S E+I   + AGM VAR +FS  D   H+   + +R A+    +   ++
Sbjct: 6    KIVCTLGPATNSDELILALVEAGMDVARLNFSHGDYADHKAAYERVRVASDATGRAVGVL 65

Query: 477  LDTVGPEIQVHNPTGGAIELIGGNHVTITPDLSKAPSADILPIKFGDLAKVVKKGDTLFI 656
             D  GP+I++     G      G  V IT    +  S D +   +  LA+    GD + +
Sbjct: 66   ADLQGPKIRLGRFATGPTYWADGETVRITVADCEG-SHDRVSTTYKKLAEDAAVGDRVLV 124

Query: 657  GQYLFTGSETTSLWLEVMETSGEEVICFVKNTATLSGPIFT---LHVSQVHISMPTLSEY 827
                    +   + L V    G++VIC    T    GP+     + +  +++S P LSE 
Sbjct: 125  --------DDGKVCLVVDGIEGDDVIC----TVVEGGPVSNNKGISLPGMNVSAPALSEK 172

Query: 828  DKQVISTWGLDNSVDIISLSHTRSSEDVRELRAFLQSHNLQDTQIYAKIENAEGLEHFDE 1007
            D + + T+ LD  VD+++LS  RS  DV EL   +     +   + AK+E  E +++ + 
Sbjct: 173  DIEDL-TFALDLGVDLVALSFVRSPADV-ELVHEVMDRVGRRVPVIAKLEKPEAVDNLET 230

Query: 1008 ILQEADGIIISRGDLGIDLPPERVFMSQKTGIHKCNMAGKPVII-TRVVDSMIDNLRPTR 1184
            I+   D I+++RGDLG++LP E V + QK  I       KPVI+ T+++DSMI+N RPTR
Sbjct: 231  IVLAFDAIMVARGDLGVELPLEEVPLVQKRAIQMARENAKPVIVATQMLDSMIENSRPTR 290

Query: 1185 AEATDVANAVLDGTDGILLGAETLRGQYPVDAVSTVGRICAEAE---TVYNQSLHFKKVV 1355
            AEA+DVANAVLDG D ++L  ET  G+YP+ AV T+ RI    E   T      H  +  
Sbjct: 291  AEASDVANAVLDGADAVMLSGETSVGKYPMAAVRTMSRIICAVEDNSTAAPPLTHVPRTK 350

Query: 1356 RHVGEPMAHEEXXXXXXXXXXXXXXXXXIVVFTFSGRAARLVAKYRPPMPVLA 1514
            R V    A +                  +V FT SG   + +A+   P+P+LA
Sbjct: 351  RGVISYAARD---------IGERLDAKALVAFTQSGDTVKRLARLHTPLPLLA 394

---

>O06134:KPYK_MYCTU Pyruvate kinase - Mycobacterium tuberculosis|
          Length = 472

 Score =  182 bits (462), Expect = 5e-45
 Identities = 135/413 (32%), Positives = 210/413 (50%), Gaps = 7/413 (1%)
 Frame = +3

Query: 297  KIVGTLGPNSHSVEVIEECLTAGMSVARFDFSWKDATYHQETLDNLRKAAQNVKKLCPIM 476
            KIV TLGP +   +++   + AGM VAR +FS  D   H+   + +R A+    +   ++
Sbjct: 6    KIVCTLGPATQRDDLVRALVEAGMDVARMNFSHGDYDDHKVAYERVRVASDATGRAVGVL 65

Query: 477  LDTVGPEIQVHNPTGGAIELIGGNHVTITPDLSKAPSADILPIKFGDLAKVVKKGDTLFI 656
             D  GP+I++     GA     G  V IT    +  S D +   +  LA+    GD + +
Sbjct: 66   ADLQGPKIRLGRFASGATHWAEGETVRITVGACEG-SHDRVSTTYKRLAQDAVAGDRVLV 124

Query: 657  GQYLFTGSETTSLWLEVMETSGEEVICFVKNTATLSGPIFT---LHVSQVHISMPTLSEY 827
                    +   + L V    G++V+C    T    GP+     + +  ++++ P LSE 
Sbjct: 125  --------DDGKVALVVDAVEGDDVVC----TVVEGGPVSDNKGISLPGMNVTAPALSEK 172

Query: 828  DKQVISTWGLDNSVDIISLSHTRSSEDVRELRAFLQSHNLQDTQIYAKIENAEGLEHFDE 1007
            D + + T+ L+  VD+++LS  RS  DV EL   +     +   + AK+E  E +++ + 
Sbjct: 173  DIEDL-TFALNLGVDMVALSFVRSPADV-ELVHEVMDRIGRRVPVIAKLEKPEAIDNLEA 230

Query: 1008 ILQEADGIIISRGDLGIDLPPERVFMSQKTGIHKCNMAGKPVII-TRVVDSMIDNLRPTR 1184
            I+   D ++++RGDLG++LP E V + QK  I       KPVI+ T+++DSMI+N RPTR
Sbjct: 231  IVLAFDAVMVARGDLGVELPLEEVPLVQKRAIQMARENAKPVIVATQMLDSMIENSRPTR 290

Query: 1185 AEATDVANAVLDGTDGILLGAETLRGQYPVDAVSTVGR-ICA--EAETVYNQSLHFKKVV 1355
            AEA+DVANAVLDG D ++L  ET  G+YP+ AV T+ R ICA  E  T      H  +  
Sbjct: 291  AEASDVANAVLDGADALMLSGETSVGKYPLAAVRTMSRIICAVEENSTAAPPLTHIPRTK 350

Query: 1356 RHVGEPMAHEEXXXXXXXXXXXXXXXXXIVVFTFSGRAARLVAKYRPPMPVLA 1514
            R V    A +                  +V FT SG   R +A+   P+P+LA
Sbjct: 351  RGVISYAARD---------IGERLDAKALVAFTQSGDTVRRLARLHTPLPLLA 394

---

>Q9PK61:KPYK_CHLMU Pyruvate kinase - Chlamydia muridarum|
          Length = 481

 Score =  180 bits (456), Expect = 2e-44
 Identities = 142/492 (28%), Positives = 248/492 (50%), Gaps = 9/492 (1%)
 Frame = +3

Query: 294  TKIVGTLGPNSHSVEVIEECLTAGMSVARFDFSWKDATYHQETLDNLRKAAQNVKKLCPI 473
            TKI+ T+GP +++ E++E+ L AGM+VAR +FS      H  T+  L++  +  +    I
Sbjct: 5    TKIICTIGPATNTPEMLEKLLDAGMNVARLNFSHGTHESHGRTIAILKELREKRQVPLAI 64

Query: 474  MLDTVGPEI---QVHNPTGGAIELIGGNHVTIT-PDLSKAPSADILPIKFGDLAKVVKKG 641
            MLDT GPEI   QV +P    I++  G+ +T+T  ++  +  A +          V ++ 
Sbjct: 65   MLDTKGPEIRLGQVESP----IKVKPGDRLTLTSKEILGSKEAGVTLYPSCVFPFVRERA 120

Query: 642  DTLFIGQYL---FTGSETTSLWLEVMETSGEEVICFVKNTATLSGPIFTLHVSQVHISMP 812
              L    Y+      ++   + +E  + SGE     +K+  +LS       +  + +++P
Sbjct: 121  PVLIDDGYIQAVVVNAQEHLIEIE-FQNSGE-----IKSNKSLS-------IKDIDVALP 167

Query: 813  TLSEYDKQVISTWGLDNSVDIISLSHTRSSEDVRELRAFLQSHNLQDTQIYAKIENAEGL 992
             ++E D   +  +G++  +D+I+ S  R +ED+  +R  L++    +  I AKIEN  G+
Sbjct: 168  FMTEKDITDLK-FGVEQELDLIAASFVRCNEDIDSMRKVLENFGRPNMPIIAKIENHLGV 226

Query: 993  EHFDEILQEADGIIISRGDLGIDLPPERVFMSQKTGIHKCNMAGK-PVIITRVVDSMIDN 1169
            ++F EI + +DGI+I+RGDLGI+L    V   QK         G+  +  T++++SMI N
Sbjct: 227  QNFQEIAKASDGIMIARGDLGIELSIVEVPALQKFMARVSRETGRFCITATQMLESMIRN 286

Query: 1170 LRPTRAEATDVANAVLDGTDGILLGAETLRGQYPVDAVSTVGRICAEAETVYNQSLHFKK 1349
              PTRAE +DVANA+ DGT  ++L  ET  G YP++AV T+  I  E E  ++    F+ 
Sbjct: 287  PLPTRAEVSDVANAIHDGTSAVMLSGETASGTYPIEAVKTMRSIIQETEKSFDYQAFFQL 346

Query: 1350 VVRHVGEPMA-HEEXXXXXXXXXXXXXXXXXIVVFTFSGRAARLVAKYRPPMPVLAVVFP 1526
              ++    ++ + E                 I+V+T +G +   ++KYRP +P++AV   
Sbjct: 347  NDKNSALKVSPYLEAIGASGIQIAEKASAKAIIVYTQTGGSPMFLSKYRPYLPIIAVT-- 404

Query: 1527 REGSDPSKWRSYGTTQARQCFSVRGVYPLMGSTDEAETGGLTKEAYGIKLALNYGRSVGI 1706
                 P++   Y      +     GVYP++ S         +        A  YG   GI
Sbjct: 405  -----PNRNVYY------RLAVEWGVYPMLTSE--------SNRTVWRHQACVYGVEKGI 445

Query: 1707 IKPYDRVIIFEK 1742
            +  YD++++F +
Sbjct: 446  LSNYDKILVFSR 457

---

>Q46078:KPYK_CORGL Pyruvate kinase - Corynebacterium glutamicum (Brevibacterium flavum)|
          Length = 475

 Score =  176 bits (447), Expect = 3e-43
 Identities = 141/432 (32%), Positives = 210/432 (48%), Gaps = 6/432 (1%)
 Frame = +3

Query: 294  TKIVGTLGPNSHSVEVIEECLTAGMSVARFDFSWKDATYHQETLDNLRKAAQNVKKLCPI 473
            TKIV TLGP   S + I   +  GM VAR +FS  D   H++    +R+AA+   +   I
Sbjct: 5    TKIVCTLGPAVASADGILRLVEDGMDVARLNFSHGDHPDHEQNYKWVREAAEKTGRAVGI 64

Query: 474  MLDTVGPEIQVHNPTGGAIELIGGNHVTITPDLSKAPSADILPIKFGDLAKVVKKGDTLF 653
            + D  GP+I++   T GA     G  + IT D  +  + D +   + +LAK  K GD L 
Sbjct: 65   LADLQGPKIRLGRFTDGATVWENGETIRITVDDVEG-THDRVSTTYKNLAKDAKPGDRLL 123

Query: 654  IGQYLFTGSETTSLWLEVMETSGEEVICFVKNTATLSGPIFT---LHVSQVHISMPTLSE 824
            +        +   + L  +   G +VIC V       GP+     + +  + IS+P LSE
Sbjct: 124  V--------DDGKVGLVCVSVEGNDVICEVVE----GGPVSNNKGVSLPGMDISVPALSE 171

Query: 825  YDKQVISTWGLDNSVDIISLSHTRSSEDVRELRAFLQSHNLQDTQIYAKIENAEGLEHFD 1004
             D + +  + L   VD I+LS  RS  D   +   +     +   + AK+E  E +   +
Sbjct: 172  KDIRDLR-FALKLGVDFIALSFVRSPADAELVHKIMDEEGRR-VPVIAKLEKPEAVTSLE 229

Query: 1005 EILQEADGIIISRGDLGIDLPPERVFMSQKTGIHKCNMAGKPVII-TRVVDSMIDNLRPT 1181
             I+   D ++++RGDLG+++P E V + QK  I       KPVI+ T+++DSMI+N RPT
Sbjct: 230  PIVLAFDAVMVARGDLGVEVPLEEVPLVQKRAIQIARENAKPVIVATQMLDSMIENSRPT 289

Query: 1182 RAEATDVANAVLDGTDGILLGAETLRGQYPVDAVSTVGRICAEAET--VYNQSLHFKKVV 1355
            RAEA+DVANAVLDG D ++L  ET  G+ P + V T+ RI   AET        H  +  
Sbjct: 290  RAEASDVANAVLDGADAVMLSGETSVGKDPHNVVRTMSRIVRFAETDGRVPDLTHIPRTK 349

Query: 1356 RHVGEPMAHEEXXXXXXXXXXXXXXXXXIVVFTFSGRAARLVAKYRPPMPVLAVVFPREG 1535
            R V    A +                  +V FT SG  A+ VA+    +P+L V  P E 
Sbjct: 350  RGVISYSARD---------IAERLNARALVAFTTSGDTAKRVARLHSHLPLL-VFTPNEA 399

Query: 1536 SDPSKWRSYGTT 1571
                   ++G T
Sbjct: 400  VRSELALTWGAT 411

---

>P94685:KPYK_CHLTR Pyruvate kinase - Chlamydia trachomatis|
          Length = 485

 Score =  176 bits (446), Expect = 4e-43
 Identities = 143/492 (29%), Positives = 249/492 (50%), Gaps = 9/492 (1%)
 Frame = +3

Query: 294  TKIVGTLGPNSHSVEVIEECLTAGMSVARFDFSWKDATYHQETLDNLRKAAQNVKKLCPI 473
            TKI+ T+GP +++ E++E+ L AGM+VAR +FS      H  T+  L++  +  +    I
Sbjct: 5    TKIICTIGPATNTPEMLEKLLDAGMNVARLNFSHGTHESHGRTIAILKELREKRQVPLAI 64

Query: 474  MLDTVGPEI---QVHNPTGGAIELIGGNHVT-ITPDLSKAPSADILPIKFGDLAKVVKKG 641
            MLDT GPEI   QV +P    I++  G+ +T ++ ++  +  + +          V ++ 
Sbjct: 65   MLDTKGPEIRLGQVESP----IKVQPGDRLTLVSKEILGSKESGVTLYPSCVFPYVRERA 120

Query: 642  DTLFIGQYL---FTGSETTSLWLEVMETSGEEVICFVKNTATLSGPIFTLHVSQVHISMP 812
              L    Y+      ++   + +E  + SGE     +K+  +LS       +  + +++P
Sbjct: 121  PVLIDDGYIQAVVVNAQEHMVEIE-FQNSGE-----IKSNKSLS-------IKDIDVALP 167

Query: 813  TLSEYDKQVISTWGLDNSVDIISLSHTRSSEDVRELRAFLQSHNLQDTQIYAKIENAEGL 992
             ++E D   +  +G++  +D+I+ S  R +ED+  +R  L+S    +  I AKIEN  G+
Sbjct: 168  FMTEKDIADLK-FGVEQELDLIAASFVRCNEDIDSMRKVLESFGRPNMPIIAKIENHLGV 226

Query: 993  EHFDEILQEADGIIISRGDLGIDLPPERVFMSQKTGIHKCNMAGK-PVIITRVVDSMIDN 1169
            ++F EI + ADGI+I+RGDLGI+L    V   QK         G+  +  T++++SMI N
Sbjct: 227  QNFQEIARAADGIMIARGDLGIELSIVEVPGLQKFMARASRETGRFCITATQMLESMIRN 286

Query: 1170 LRPTRAEATDVANAVLDGTDGILLGAETLRGQYPVDAVSTVGRICAEAETVYNQSLHFKK 1349
              PTRAE +DVANA+ DGT  ++L  ET  G +PV AV T+  I  E E  ++    F+ 
Sbjct: 287  PLPTRAEVSDVANAIYDGTSAVMLSGETALGAHPVHAVKTMRSIIQETEKTFDYHAFFQL 346

Query: 1350 VVRHVGEPMA-HEEXXXXXXXXXXXXXXXXXIVVFTFSGRAARLVAKYRPPMPVLAVVFP 1526
              ++    ++ + E                 I+V+T +G +   ++KYRP +P++AV   
Sbjct: 347  NDKNSALKVSPYLEAIGFSGIQIAEKASAKAIIVYTQTGGSPMFLSKYRPYLPIIAVT-- 404

Query: 1527 REGSDPSKWRSYGTTQARQCFSVRGVYPLMGSTDEAETGGLTKEAYGIKLALNYGRSVGI 1706
                 P++   Y      +     GVYP++  T E+       +      A  YG   GI
Sbjct: 405  -----PNRNVYY------RLAVEWGVYPML--TLESNRTVWRHQ------ACVYGVEKGI 445

Query: 1707 IKPYDRVIIFEK 1742
            +  YD++++F +
Sbjct: 446  LSNYDKILVFSR 457

---

>Q44473:KPYK2_AGRVI Pyruvate kinase - Agrobacterium vitis (Rhizobium vitis)|
          Length = 482

 Score =  175 bits (443), Expect = 8e-43
 Identities = 116/411 (28%), Positives = 204/411 (49%), Gaps = 3/411 (0%)
 Frame = +3

Query: 294  TKIVGTLGPNSHSVEVIEECLTAGMSVARFDFSWKDATYHQETLDNLRKAAQNVKKLCPI 473
            +KIV T+GP S S +++     AG+   R +FS      H E   N+R   Q       +
Sbjct: 9    SKIVATVGPASSSPDMLRSLFLAGVDTFRLNFSHGARADHAEVYRNIRALEQEHDAAIAV 68

Query: 474  MLDTVGPEIQVHNPTGGAIELIGGNHVTITPDLSKAPSADILPIKFGDLAKVVKKGDTLF 653
            + D  GP+I++     G ++L  G+ +            + +P+   ++ +V   G  L 
Sbjct: 69   LQDLQGPKIRIGVLAHGRLDLARGSTIGFILGREGGEGMNDIPLPHREIFEVAVPGMDLL 128

Query: 654  IGQYLFTGSETTSLWLEVMETSGEEVICFVKNTATLSGPIFTLHVSQVHISMPTLSEYDK 833
            I        +   + + +ME     ++C V N   LS     ++V    + +  L+  D+
Sbjct: 129  I--------DDGRIKVRIMEVMDGRLVCEVLNGGALSNRK-GVNVPGAVLDISPLTAKDR 179

Query: 834  QVISTWGLDNSVDIISLSHTRSSEDVRELRAFLQSHNLQDTQIYAKIENAEGLEHFDEIL 1013
            + +  +GL+  VD ++LS  + + D+ E R+ +         + AKIE    L+  ++I+
Sbjct: 180  EDLE-FGLELGVDWVALSFVQRARDMIEARSLVGDR----AGLIAKIEKPSALDDIEDIV 234

Query: 1014 QEADGIIISRGDLGIDLPPERVFMSQKTGIHKCNMAGKPVII-TRVVDSMIDNLRPTRAE 1190
            + +D ++++RGDLG+++PPE V   QK  I  C +A KPVI+ T+++DSM+ +  PTRAE
Sbjct: 235  RLSDSVMVARGDLGVEIPPEDVPGKQKEIIRACRLAAKPVIVATQMLDSMVSSPTPTRAE 294

Query: 1191 ATDVANAVLDGTDGILLGAETLRGQYPVDAVSTVGRICAEAETVYNQSLHFKKVVRHVGE 1370
            A+DVA A+ DG D ++L AET  G YPV+AV  + RI  + E    +  H++ ++     
Sbjct: 295  ASDVAGAIYDGADAVMLSAETATGAYPVEAVEIMNRIIEKTE----KHKHYRPILEATEP 350

Query: 1371 PMAHE--EXXXXXXXXXXXXXXXXXIVVFTFSGRAARLVAKYRPPMPVLAV 1517
             +A                      +V +T SG  A  +++ RP +P+LA+
Sbjct: 351  DVAQSPPHAVATAAANVAVALGSPVVVAYTSSGTTAARISRARPALPILAL 401

---

>Q8FP04:KPYK_COREF Pyruvate kinase - Corynebacterium efficiens|
          Length = 474

 Score =  174 bits (442), Expect = 1e-42
 Identities = 147/463 (31%), Positives = 216/463 (46%), Gaps = 6/463 (1%)
 Frame = +3

Query: 294  TKIVGTLGPNSHSVEVIEECLTAGMSVARFDFSWKDATYHQETLDNLRKAAQNVKKLCPI 473
            TKIV TLGP   S + I   +  GM VAR +FS  D   H++    +R+A     +   I
Sbjct: 5    TKIVCTLGPAVASADGILRLVQDGMDVARLNFSHGDHPDHEQNYKWVREATDKTGRAVGI 64

Query: 474  MLDTVGPEIQVHNPTGGAIELIGGNHVTITPDLSKAPSADILPIKFGDLAKVVKKGDTLF 653
            + D  GP+I++     G+     G  V IT D  +  + D +   + +LAK  + GD L 
Sbjct: 65   LADLQGPKIRLGRFKEGSTVWETGETVRITVDDVEG-THDRVSTTYKNLAKDARPGDRLL 123

Query: 654  IGQYLFTGSETTSLWLEVMETSGEEVICFVKNTATLSGPIFT---LHVSQVHISMPTLSE 824
            +        +   + L  +   G +VIC V    T  GP+     + +  + IS+P LSE
Sbjct: 124  V--------DDGKVGLVCVSVEGNDVICEV----TEGGPVSNNKGVSLPGMDISVPALSE 171

Query: 825  YDKQVISTWGLDNSVDIISLSHTRSSEDVRELRAFLQSHNLQDTQIYAKIENAEGLEHFD 1004
             D + +  + L   VD I+LS  RS  DV  + A +     +   + AK+E  E +   +
Sbjct: 172  KDIKDLR-FALKLGVDFIALSFVRSPADVELVHAIMDEEGRR-VPVIAKLEKPEAVAALE 229

Query: 1005 EILQEADGIIISRGDLGIDLPPERVFMSQKTGIHKCNMAGKPVII-TRVVDSMIDNLRPT 1181
             I+   D I+++RGDLG+++P E V + QK  I       KPVI+ T+++DSMI+N RPT
Sbjct: 230  SIVLAFDAIMVARGDLGVEVPLEEVPLVQKRAIQIARENAKPVIVATQMLDSMIENSRPT 289

Query: 1182 RAEATDVANAVLDGTDGILLGAETLRGQYPVDAVSTVGRICAEAET--VYNQSLHFKKVV 1355
            RAEA+DVANAVLDG D ++L  ET  G+ P + V T+ RI   AET        H  +  
Sbjct: 290  RAEASDVANAVLDGADAVMLSGETSVGKDPHNVVRTMSRIVRFAETDGRVPDLTHIPRTK 349

Query: 1356 RHVGEPMAHEEXXXXXXXXXXXXXXXXXIVVFTFSGRAARLVAKYRPPMPVLAVVFPREG 1535
            R V    A +                  +V FT SG  A+ +A+    +P+L        
Sbjct: 350  RGVISYSARD---------IAERLNARALVAFTTSGDTAKRLARLHSHLPLLVFT----- 395

Query: 1536 SDPSKWRSYGTTQARQCFSVRGVYPLMGSTDEAETGGLTKEAY 1664
             DPS       T   Q F    V    G   E +   L  + Y
Sbjct: 396  PDPSVRSQLALTWGAQTFLCPKVDDTDGMMREVDRALLAMDEY 438

---

>Q40546:KPYG_TOBAC Pyruvate kinase isozyme G, chloroplast precursor - Nicotiana tabacum|
            (Common tobacco)
          Length = 562

 Score =  173 bits (438), Expect = 3e-42
 Identities = 131/419 (31%), Positives = 213/419 (50%), Gaps = 9/419 (2%)
 Frame = +3

Query: 285  PSLTKIVGTLGPNSHSVEVIEECLTAGMSVARFDFSWKDATYHQETLDNLRKA-AQNVKK 461
            P  TKIV T+GP++ S E+I +   AGM+VAR + S  D   HQ T+D +++  AQ   K
Sbjct: 90   PRKTKIVCTIGPSTSSREMIWKLAEAGMNVARLNMSHGDHASHQRTIDLVKEYNAQFEDK 149

Query: 462  LCPIMLDTVGPEIQVHNPTGGAIELIGGNHVTITPDLSKAPSADILPIKFGDLAKVVKKG 641
            +  IMLDT GPE+ +       I L  G     +     + + D + + + D    V+ G
Sbjct: 150  VIAIMLDTKGPEV-ISGDVPKPILLKEGQEFNFSIKRGVS-TEDTVSVNYDDFINDVEAG 207

Query: 642  DTLFIGQYLFTGSETTSLWLEVMETSGEEVICFVKNTATLSGPIFTLHVSQVHISMPTLS 821
            D L +   + +        L V   + + V C V +   L      L+V     ++P+++
Sbjct: 208  DILLVDGGMMS--------LAVKSKTSDIVKCEVIDGGELKSRRH-LNVRGKSATLPSIT 258

Query: 822  EYDKQVISTWGLDNSVDIISLSHTRSSEDVRELRAFLQSHNLQDTQIYAKIENAEGLEHF 1001
            E D   I  +G++N VD  ++S  + ++ V EL+ +L+S N  D  +  KIE+A+ + + 
Sbjct: 259  EKDWDDIK-FGVNNQVDFYAVSFVKDAKVVHELKDYLKSCNA-DIHVIVKIESADSIPNL 316

Query: 1002 DEILQEADGIIISRGDLGIDLPPERVFMSQKTGIHKCNMAGKPVII-TRVVDSMIDNLRP 1178
              I+  +DG +++RGDLG +LP E V + Q+  I +C    KPVI+ T +++SMID+  P
Sbjct: 317  HSIISASDGAMVARGDLGAELPIEEVPLLQEDIIRRCQSMQKPVIVATNMLESMIDHPTP 376

Query: 1179 TRAEATDVANAVLDGTDGILLGAETLRGQYPVDAVSTVGRICAEAETVY-------NQSL 1337
            TRAE +D++ AV +G D ++L  ET  G+YP+ AV  +  +    E+         +QS 
Sbjct: 377  TRAEVSDISIAVREGADAVMLSGETAHGKYPLKAVKVMHIVALRTESSLQKSTSSPSQSA 436

Query: 1338 HFKKVVRHVGEPMAHEEXXXXXXXXXXXXXXXXXIVVFTFSGRAARLVAKYRPPMPVLA 1514
             +K    H+GE  A                    I+VFT +G  A +++  RP   V A
Sbjct: 437  AYKS---HMGEMFAFHS-------SSMANTLSTPIIVFTRTGSMAIILSHNRPSSTVFA 485

---

>Q9Z984:KPYK_CHLPN Pyruvate kinase - Chlamydia pneumoniae (Chlamydophila pneumoniae)|
          Length = 484

 Score =  172 bits (436), Expect = 5e-42
 Identities = 141/488 (28%), Positives = 230/488 (47%), Gaps = 5/488 (1%)
 Frame = +3

Query: 294  TKIVGTLGPNSHSVEVIEECLTAGMSVARFDFSWKDATYHQETLDNLRKAAQNVKKLCPI 473
            TKI+ T+GP ++S E++ + L AGM+VAR +FS      H + +  L++  +  +    I
Sbjct: 5    TKIICTIGPATNSPEMLAKLLDAGMNVARLNFSHGSHETHGQAIGFLKELREQKRVPLAI 64

Query: 474  MLDTVGPEIQVHNPTGGAIELIGGNHVTITPDLSKAPSADILPIKFGDLAKVVKKGDTLF 653
            MLDT GPEI++ N         G     ++ D+  +    +     G    V +  D L 
Sbjct: 65   MLDTKGPEIRLGNIPQPISVSQGQKLRLVSSDIDGSAEGGVSLYPKGIFPFVPEGADVLI 124

Query: 654  IGQYLFT---GSETTSLWLEVMETSGEEVICFVKNTATLSGPIFTLHVSQVHISMPTLSE 824
               Y+      SE  SL LE M +        +K+  +LS       +  V +++P ++E
Sbjct: 125  DDGYIHAVVVSSEADSLELEFMNSG------LLKSHKSLS-------IRGVDVALPFMTE 171

Query: 825  YDKQVISTWGLDNSVDIISLSHTRSSEDVRELRAFLQSHNLQDTQIYAKIENAEGLEHFD 1004
             D   +  +G++ ++D+++ S  R  ED+  +R  L         I AKIEN  G+E+F 
Sbjct: 172  KDIADLK-FGVEQNMDVVAASFVRYGEDIETMRKCLADLGNPKMPIIAKIENRLGVENFS 230

Query: 1005 EILQEADGIIISRGDLGIDLPPERVFMSQKTGIHKCNMAGK-PVIITRVVDSMIDNLRPT 1181
            +I + ADGI+I+RGDLGI+L    V   QK         G   V  T++++SMI N+ PT
Sbjct: 231  KIAKLADGIMIARGDLGIELSVVEVPNLQKMMAKVSRETGHFCVTATQMLESMIRNVLPT 290

Query: 1182 RAEATDVANAVLDGTDGILLGAETLRGQYPVDAVSTVGRICAEAETVYNQSLHFKKVVRH 1361
            RAE +D+ANA+ DG+  ++L  ET  G +PV AV  +  +  E E   +     K    +
Sbjct: 291  RAEVSDIANAIYDGSSAVMLSGETASGAHPVAAVKIMRSVILETEKNLSHDSFLKLDDSN 350

Query: 1362 VG-EPMAHEEXXXXXXXXXXXXXXXXXIVVFTFSGRAARLVAKYRPPMPVLAVVFPREGS 1538
               +   +                   ++V+T SG +   ++KYRP  P++AV       
Sbjct: 351  SALQVSPYLSAIGLAGIQIAERADAKALIVYTESGSSPMFLSKYRPKFPIIAVT------ 404

Query: 1539 DPSKWRSYGTTQARQCFSVRGVYPLMGSTDEAETGGLTKEAYGIKLALNYGRSVGIIKPY 1718
             PS      T+   +     GVYP++  T E++       A     A  YG   GI+  Y
Sbjct: 405  -PS------TSVYYRLALEWGVYPML--TQESD------RAVWRHQACIYGIEQGILSNY 449

Query: 1719 DRVIIFEK 1742
            DR+++  +
Sbjct: 450  DRILVLSR 457

---

>O51323:KPYK_BORBU Pyruvate kinase - Borrelia burgdorferi (Lyme disease spirochete)|
          Length = 477

 Score =  167 bits (424), Expect = 1e-40
 Identities = 117/412 (28%), Positives = 207/412 (50%), Gaps = 6/412 (1%)
 Frame = +3

Query: 291  LTKIVGTLGPNSHSVEVIEECLTAGMSVARFDFSWKDATYHQETLDNLRKAAQNVKKLCP 470
            LTKIV T+       E I++   AG++V R + + +      + +DN+RK +  +     
Sbjct: 5    LTKIVATISDLRCEPEHIKDLHDAGVNVIRLNTAHQSHEDTIKVIDNVRKISNKIA---- 60

Query: 471  IMLDTVGPEIQVHNPTGGAIELIGGNHVTITPDLSKAPSADILPIKFGDLAKVVKKGDTL 650
            +M+DT GPE++  N     I   G   +  T  +++  +       +    K V +G  +
Sbjct: 61   LMIDTKGPEVRTANIENPIIVKTGDKVIISTSPINEPNN---FQTNYDGFVKEVPQGSKV 117

Query: 651  FIGQYLFTGSETTSLWLEVMETSGEEVICFVKNTATLSGPIFTLHVSQVHISMPTLSEYD 830
             I        +   L + V+    + +IC +KN   +     +++   + + + +++E D
Sbjct: 118  LI--------DDGELEMTVVAKLPDRLICEIKNDGQIKNKK-SINTPGISLKLQSVTEKD 168

Query: 831  KQVISTWGLDNSVDIISLSHTRSSEDVRELRAFLQSHNLQDTQIYAKIENAEGLEHFDEI 1010
            K  I      N VD I+ S  R S+DV++++  L +    D +I +KIEN EG+++ +EI
Sbjct: 169  KGFIELAAKYN-VDFIAHSFVRHSKDVQDVQEILTASGNPDVKIISKIENQEGIDNIEEI 227

Query: 1011 LQEADGIIISRGDLGIDLPPERVFMSQKTGIHKCNMAGKPVI-ITRVVDSMIDNLRPTRA 1187
             + + GI+++RGD+G+++P E V ++Q      C   G PVI  T+++ +MI+N RPTRA
Sbjct: 228  AKASYGIMVARGDMGVEIPAEDVPIAQLKITQTCIKYGIPVITATQMLHTMIENPRPTRA 287

Query: 1188 EATDVANAVLDGTDGILLGAETLRGQYPVDAVSTVGRICAEAE-----TVYNQSLHFKKV 1352
            E +D+ANA+L+GTD I+L  ET  G+YP++AV  +  I  + E     T+Y   L + K 
Sbjct: 288  EVSDIANAILNGTDAIMLSGETAYGKYPIEAVKMMTSIAKKVEKHRKMTLYKDELFYDKS 347

Query: 1353 VRHVGEPMAHEEXXXXXXXXXXXXXXXXXIVVFTFSGRAARLVAKYRPPMPV 1508
            +                            I+V +  G+ AR++A YR  +P+
Sbjct: 348  IT--------RNYIIKCAIDATKLMDIKAIIVDSLKGKTARIMATYRASVPL 391

---

>P70789:KPYK1_AGRVI Pyruvate kinase - Agrobacterium vitis (Rhizobium vitis)|
          Length = 474

 Score =  165 bits (418), Expect = 6e-40
 Identities = 116/413 (28%), Positives = 200/413 (48%), Gaps = 6/413 (1%)
 Frame = +3

Query: 297  KIVGTLGPNSHSVEVIEECLTAGMSVARFDFSWKDATYHQETLDNLRKAAQNVKKLCPIM 476
            KIV T+GP S S  ++     AG+   R +FS      H     ++R   + +     I+
Sbjct: 10   KIVATVGPASSSPAILRSLFLAGVDTFRLNFSHGSRDDHAAAYRHIRALEKELGTSIGIL 69

Query: 477  LDTVGPEIQVHNPTGGAIELIGGNHVTITPDLSKAPSADILPIKFGDLAKVVKKGDTLFI 656
             D  GP+I++     G ++L     +              +P+   ++   VK GD L I
Sbjct: 70   QDLQGPKIRIGVLHEGRLQLTKDAEIRFVCGTEPGRGLMDIPLPHREIFAAVKPGDDLLI 129

Query: 657  GQYLFTGSETTSLWLEVMETSGEEVICFVKNTATLSGPIFT---LHVSQVHISMPTLSEY 827
                    +   + +  +  S E    F+     ++GPI     +++    + +  L+  
Sbjct: 130  --------DDGRVRVRALGVSDE----FIDAKVIVAGPISNRKGVNLPGTVLDISPLTPK 177

Query: 828  DKQVISTWGLDNSVDIISLSHTRSSEDVRELRAFLQSHNLQDTQIYAKIENAEGLEHFDE 1007
            D++ +  +GL+  VD I+LS  +++ D+ E R+ +         + AKIE    L+  D+
Sbjct: 178  DRKDLE-FGLELGVDWIALSFVQTARDMIEARSLVSDR----AGLIAKIEKPSALDEIDD 232

Query: 1008 ILQEADGIIISRGDLGIDLPPERVFMSQKTGIHKCNMAGKPVII-TRVVDSMIDNLRPTR 1184
            I+  +D I+++RGDLG+++PPE V   QK  I  C +A KPVI+ T+++DSM+ +  PTR
Sbjct: 233  IVALSDAIMVARGDLGVEIPPEDVPGRQKELIRACRIAAKPVIVATQMLDSMVTSPTPTR 292

Query: 1185 AEATDVANAVLDGTDGILLGAETLRGQYPVDAVSTVGRICAEAETVYNQSLHFKKVVRHV 1364
            AEA+DVA A+ DG D ++L AE+  G +PV+ V  + RI  + E    +   ++ ++   
Sbjct: 293  AEASDVAGAIYDGADAVMLSAESATGAFPVETVEIMSRIIEKTE----KHKFYRPILEAT 348

Query: 1365 GEPMAH--EEXXXXXXXXXXXXXXXXXIVVFTFSGRAARLVAKYRPPMPVLAV 1517
               +AH                     IV FT SG  A  +++ RPP+P+LA+
Sbjct: 349  EPQIAHTPPHAVATAAADVALALKAPVIVAFTVSGTTASRISRARPPLPILAL 401

---

>Q07637:KPYK_LACLA Pyruvate kinase - Lactococcus lactis subsp. lactis (Streptococcus|
            lactis)
          Length = 502

 Score =  164 bits (414), Expect = 2e-39
 Identities = 129/412 (31%), Positives = 201/412 (48%), Gaps = 14/412 (3%)
 Frame = +3

Query: 330  SVEVIEECLTAGMSVARFDFSWKDATYHQETLDNLRKAAQNVKKLCPIMLDTVGPEIQVH 509
            S + I   +  G +V RF+FS  D       +  + +A +        +LDT GPE++  
Sbjct: 38   SAKNIAALIEEGANVFRFNFSHGDHPEQGARMATVHRAEEIAGHKVGFLLDTKGPEMRTE 97

Query: 510  NPTGGA--IELIGGN--HVTITPDLSKAPSADILPIKFG-DLAKVVKKGDTLFIGQ---- 662
                GA  I ++ G+   V     L   P    L +  G D+   V+ G T+ I      
Sbjct: 98   LFADGADAISVVTGDKFRVATKQGLKSTPELIALNVAGGLDIFDDVEIGQTILIDDGKLG 157

Query: 663  YLFTGSETTSLWLEVMETSGEEVICFVKNTATLSGPIFTLHVSQVHISMPTLSEYDKQVI 842
               TG +  +   EV E   + VI   K           +++    I  P L+E D   I
Sbjct: 158  LSLTGKDAATREFEV-EAQNDGVIGKQKG----------VNIPNTKIPFPALAERDDADI 206

Query: 843  STWGLDN--SVDIISLSHTRSSEDVRELRAFLQSHNLQDTQIYAKIENAEGLEHFDEILQ 1016
              +GL     ++ I++S  R++ DV+E+R   +       Q+ AKIEN +G+E+ DEI++
Sbjct: 207  R-FGLSQPGGINFIAISFVRTANDVKEVRRICEETGNPHVQLLAKIENQQGIENLDEIIE 265

Query: 1017 EADGIIISRGDLGIDLPPERVFMSQKTGIHKCNMAGKPVI-ITRVVDSMIDNLRPTRAEA 1193
             ADGI+I+RGD+GI++P E V + QK  I K N AGK V+  T +++SM  N R TR+E 
Sbjct: 266  AADGIMIARGDMGIEVPFEMVPVYQKLIISKVNKAGKIVVTATNMLESMTYNPRATRSEI 325

Query: 1194 TDVANAVLDGTDGILLGAETLRGQYPVDAVSTVGRICAEAETVYNQ--SLHFKKVVRHVG 1367
            +DV NAV+DGTD  +L  E+  G+YP ++V T+  +   A+T+  +   LH ++      
Sbjct: 326  SDVFNAVIDGTDATMLSGESANGKYPRESVRTMATVNKNAQTMLKEYGRLHPERY----- 380

Query: 1368 EPMAHEEXXXXXXXXXXXXXXXXXIVVFTFSGRAARLVAKYRPPMPVLAVVF 1523
            +     E                 IV  T SG  ARL++K+RP   +LA+ F
Sbjct: 381  DKSTVTEVVAASVKNAAEAMDIKLIVALTESGNTARLISKHRPNADILAITF 432

---

>P21599:KPYK2_ECOLI Pyruvate kinase II - Escherichia coli|
          Length = 480

 Score =  160 bits (404), Expect = 3e-38
 Identities = 126/416 (30%), Positives = 201/416 (48%), Gaps = 8/416 (1%)
 Frame = +3

Query: 294  TKIVGTLGPNSHSVEVIEECLTAGMSVARFDFSWKDATYHQETLDNLRKAAQNVKKLCPI 473
            TKIV TLGP +     +E+ + AG +V R +FS      H+   D +R+ A  + +   I
Sbjct: 8    TKIVTTLGPATDRDNNLEKVIAAGANVVRMNFSHGSPEDHKMRADKVREIAAKLGRHVAI 67

Query: 474  MLDTVGPEIQVHNPTGGAIELIGGNHVTITPDLSKAPS-ADILPIKFGDLAKVVKKGDTL 650
            + D  GP+I+V     G + L  G+   +  +L K     + + I +  L   V  GD L
Sbjct: 68   LGDLQGPKIRVSTFKEGKVFLNIGDKFLLDANLGKGEGDKEKVGIDYKGLPADVVPGDIL 127

Query: 651  FIGQYLFTGSETTSLWLEVMETSGEEVICFVKNTATLSGPIFT---LHVSQVHISMPTLS 821
             +        +   + L+V+E  G +V   V    T+ GP+     ++     +S   L+
Sbjct: 128  LL--------DDGRVQLKVLEVQGMKVFTEV----TVGGPLSNNKGINKLGGGLSAEALT 175

Query: 822  EYDKQVISTWGLDNSVDIISLSHTRSSEDVRELRAFLQSHNLQDTQIYAKIENAEGL--- 992
            E DK  I T  L   VD +++S  R  ED+   R   +     D +I AK+E AE +   
Sbjct: 176  EKDKADIKTAALIG-VDYLAVSFPRCGEDLNYARRLARDAGC-DAKIVAKVERAEAVCSQ 233

Query: 993  EHFDEILQEADGIIISRGDLGIDLPPERVFMSQKTGIHKCNMAGKPVII-TRVVDSMIDN 1169
            +  D+I+  +D ++++RGDLG+++    +   QK  I +     + VI  T++++SMI N
Sbjct: 234  DAMDDIILASDVVMVARGDLGVEIGDPELVGIQKALIRRARQLNRAVITATQMMESMITN 293

Query: 1170 LRPTRAEATDVANAVLDGTDGILLGAETLRGQYPVDAVSTVGRICAEAETVYNQSLHFKK 1349
              PTRAE  DVANAVLDGTD ++L AET  GQYP + V+ + R+C  AE +   S++  K
Sbjct: 294  PMPTRAEVMDVANAVLDGTDAVMLSAETAAGQYPSETVAAMARVCLGAEKI--PSINVSK 351

Query: 1350 VVRHVGEPMAHEEXXXXXXXXXXXXXXXXXIVVFTFSGRAARLVAKYRPPMPVLAV 1517
                V      E                  I+  T SGR A + ++    +P+ A+
Sbjct: 352  HRLDVQFDNVEEAIAMSAMYAANHLKGVTAIITMTESGRTALMTSRISSGLPIFAM 407

---

>Q8ZNW0:KPYK2_SALTY Pyruvate kinase II - Salmonella typhimurium|
          Length = 480

 Score =  159 bits (402), Expect = 4e-38
 Identities = 126/416 (30%), Positives = 200/416 (48%), Gaps = 8/416 (1%)
 Frame = +3

Query: 294  TKIVGTLGPNSHSVEVIEECLTAGMSVARFDFSWKDATYHQETLDNLRKAAQNVKKLCPI 473
            TKIV TLGP +     +E+ + AG +V R +FS      H+   D +R+ A  + +   I
Sbjct: 8    TKIVTTLGPATDRDNNLEKVIAAGANVVRMNFSHGSPEDHKMRADKVREIAAKLGRHVAI 67

Query: 474  MLDTVGPEIQVHNPTGGAIELIGGNHVTITPDLSKAPS-ADILPIKFGDLAKVVKKGDTL 650
            + D  GP+I+V     G + L  G+   +  +L K     + + I +  L   V  GD L
Sbjct: 68   LGDLQGPKIRVSTFKEGKVFLNIGDKFLLDANLGKGEGDKEKVGIDYKGLPADVVPGDIL 127

Query: 651  FIGQYLFTGSETTSLWLEVMETSGEEVICFVKNTATLSGPIFT---LHVSQVHISMPTLS 821
             +        +   + L+V+E  G +V   V    T+ GP+     ++     +S   L+
Sbjct: 128  LL--------DDGRVQLKVLEVQGMKVFTEV----TVGGPLSNNKGINKLGGGLSAEALT 175

Query: 822  EYDKQVISTWGLDNSVDIISLSHTRSSEDVRELRAFLQSHNLQDTQIYAKIENAEGL--- 992
            E DK  I T  L   VD +++S  R  ED+   R   +     D +I AK+E AE +   
Sbjct: 176  EKDKADIQTAALIG-VDYLAVSFPRCGEDLNYARRLARDAGC-DAKIVAKVERAEAVCDQ 233

Query: 993  EHFDEILQEADGIIISRGDLGIDLPPERVFMSQKTGIHKCNMAGKPVII-TRVVDSMIDN 1169
               D+I+  +D ++++RGDLG+++    +   QK  I +     + VI  T++++SMI N
Sbjct: 234  NAMDDIILASDVVMVARGDLGVEIGDPELVGIQKALIRRARQLNRAVITATQMMESMITN 293

Query: 1170 LRPTRAEATDVANAVLDGTDGILLGAETLRGQYPVDAVSTVGRICAEAETVYNQSLHFKK 1349
              PTRAE  DVANAVLDGTD ++L AET  GQYP + V+ + R+C  AE +   S++  K
Sbjct: 294  PMPTRAEVMDVANAVLDGTDAVMLSAETAAGQYPSETVAAMARVCLGAEKI--PSINVSK 351

Query: 1350 VVRHVGEPMAHEEXXXXXXXXXXXXXXXXXIVVFTFSGRAARLVAKYRPPMPVLAV 1517
                V      E                  I+  T SGR A + ++    +P+ A+
Sbjct: 352  HRLDVQFDNVEEAIAMSAMYAANHLKGVTAIITMTESGRTALMTSRISSGLPIFAM 407

---

>P78031:KPYK_MYCPN Pyruvate kinase - Mycoplasma pneumoniae|
          Length = 508

 Score =  155 bits (392), Expect = 6e-37
 Identities = 108/361 (29%), Positives = 187/361 (51%), Gaps = 13/361 (3%)
 Frame = +3

Query: 285  PSLTKIVGTLGP---------NSHSVEVIEECLTAGMSVARFDFSWKDATYHQETLDNLR 437
            P+LTK + TL            + +   IE  +  G++V R +FS  +       +  +R
Sbjct: 16   PALTKKLWTLAMLDDPAYAAMKAEAYANIENIIKNGVTVIRLNFSHGNHEEQAVRIKIVR 75

Query: 438  KAAQNVKKLCPIMLDTVGPEIQVHNPTGGAIELIGGNHVTITPDLSKAPSADILPIKFGD 617
              A+ +     IMLDT GPEI+V       ++++  + V I     +    +   +   D
Sbjct: 76   DVAKKLNLPVSIMLDTNGPEIRVFETAPEGLKILKDSEVVINTTTKEVAKNNQFSVS--D 133

Query: 618  LAKVVKKGDTLFIGQYLFTGSETTSLWLEVMETSGEEVICFVKNTATLSGPIFT---LHV 788
             +      + + +GQ +       SL ++ ++T   +VIC  +N  T    IFT   L++
Sbjct: 134  ASGTYNMVNDVKVGQKILVDDGKLSLVVKRIDTKNNQVICVAQNDHT----IFTKKRLNL 189

Query: 789  SQVHISMPTLSEYDKQVISTWGLDNSVDIISLSHTRSSEDVRELRAFLQSHNLQDTQIYA 968
                 S+P LS  D + I  +GL + +D I+ S   ++E++++LR +L S N +  ++ A
Sbjct: 190  PNADYSIPFLSAKDLRDID-FGLTHQIDYIAASFVNTTENIKQLRDYLASKNAKHVKLIA 248

Query: 969  KIENAEGLEHFDEILQEADGIIISRGDLGIDLPPERVFMSQKTGIHKCNMAGKPVI-ITR 1145
            KIE+   L + D I++ +DGI+++RGDLG+++P  +V   Q+  I  C    K VI  T+
Sbjct: 249  KIESNHALNNIDGIIKASDGIMVARGDLGLEIPYYKVPYWQRYMIKACRFFNKRVITATQ 308

Query: 1146 VVDSMIDNLRPTRAEATDVANAVLDGTDGILLGAETLRGQYPVDAVSTVGRICAEAETVY 1325
            ++DS+  N++PTRAE TDV  AV  G D  +L  ET  G +P++AV  +  I  ++ET +
Sbjct: 309  MLDSLEKNIQPTRAEVTDVYFAVDRGNDATMLSGETANGAFPLNAVYVMKMIDKQSETFF 368

Query: 1326 N 1328
            +
Sbjct: 369  D 369

---

>P43924:KPYK_HAEIN Pyruvate kinase - Haemophilus influenzae|
          Length = 478

 Score =  155 bits (391), Expect = 8e-37
 Identities = 137/462 (29%), Positives = 214/462 (46%), Gaps = 12/462 (2%)
 Frame = +3

Query: 294  TKIVGTLGPNSHSVEVIEECLTAGMSVARFDFSWKDATYHQETLDNLRKAAQNVKKLCPI 473
            TKIV T+GP++     +E+ + AG +V R +FS      H    + +R  A+ + K   I
Sbjct: 8    TKIVCTMGPSTDRDNNLEKIIAAGANVVRMNFSHGTPDDHIGRAERVRSIAKKLGKTVAI 67

Query: 474  MLDTVGPEIQVHNPTGGAIELIGGNHVTITPDLSKAPSA-DILPIKFGDLAKVVKKGDTL 650
            + D  GP+I+V     G I L  G+   +  +L K     + + + +  L + V  GD L
Sbjct: 68   LGDLQGPKIRVSTFKDGKIFLNVGDKFILDAELPKGEGTQESVGLDYKTLPQDVVPGDIL 127

Query: 651  FIGQYLFTGSETTSLWLEVMETSGEEVICFVKNTATLSGPIFT---LHVSQVHISMPTLS 821
             +        +   + L+V+ T G +V   V    T+ GP+     ++     +S   L+
Sbjct: 128  LL--------DDGRVQLKVLSTDGAKVFTEV----TVGGPLSNNKGINKLGGGLSADALT 175

Query: 822  EYDKQVISTWGLDNSVDIISLSHTRSSEDVRELRAFLQSHNLQDTQIYAKIENAEGL--- 992
            E DK  I T      VD +++S  RSS D+   R   Q   L + +I AK+E AE +   
Sbjct: 176  EKDKADIIT-AARIGVDFLAVSFPRSSADLNYARELAQQAGL-NAKIVAKVERAETVAND 233

Query: 993  EHFDEILQEADGIIISRGDLGIDLPPERVFMSQKTGIHKCNMAGKPVII-TRVVDSMIDN 1169
            E  D+I+  +D I+++RGDLG+++    +   QK  I +     + VI  T++++SMI N
Sbjct: 234  EAMDDIILASDVIMVARGDLGVEIGDPELVGVQKKLIRRSRQLNRAVITATQMMESMISN 293

Query: 1170 LRPTRAEATDVANAVLDGTDGILLGAETLRGQYPVDAVSTVGRICAEAETV--YNQSLH- 1340
              PTRAE  DVANAVLDGTD ++L AET  GQYP + V+ +  +C  AE +   N S H 
Sbjct: 294  PMPTRAEVMDVANAVLDGTDAVMLSAETAAGQYPSETVAAMASVCLGAEKMPSINVSRHR 353

Query: 1341 FKKVVRHVGEPMAHEEXXXXXXXXXXXXXXXXXIVVFTFSGRAARLVAKYRPPMPVLAVV 1520
              K    + E +A                    IV  + +GR   L+++    +P+ A+ 
Sbjct: 354  MDKEFETIEESVA-----MSAMYAANHMKGVAAIVTLSSTGRTPLLMSRISSGLPIFAL- 407

Query: 1521 FPREGSDPSKWRSYGTTQARQCFSVRGVYPLM-GSTDEAETG 1643
                        S        C   RGV P+  G     E G
Sbjct: 408  ------------SRNQETLNLCALYRGVTPIYHGEESRTEAG 437

---

>P32044:KPYK_THEAC Pyruvate kinase - Thermoplasma acidophilum|
          Length = 544

 Score =  152 bits (384), Expect = 5e-36
 Identities = 109/412 (26%), Positives = 202/412 (49%), Gaps = 5/412 (1%)
 Frame = +3

Query: 294  TKIVGTLGPNSHSVEVIEECLTAGMSVARFDFSWKDATYHQETLDNLRKAAQNVKKLCPI 473
            TKIV T+GP S S E++++ +  G+S+ R + +  D     + +  + +  +++ +   I
Sbjct: 3    TKIVATIGPASSSPEIMKQMIDNGLSLVRINSAHADI----KDVSKITQMVRSINRDVGI 58

Query: 474  MLDTVGPEIQVHNPTGGAIELIGGNHVTITPDLSKAPSADILPIKFGDLAKVVKKGDTLF 653
            M+D  GPE++     GG +++  G    +  D+          +   ++   V+ GD + 
Sbjct: 59   MIDLKGPELRTGEFAGGTLKISSGKDYVMGKDIV---------LNNMNVLSAVQVGDRIL 109

Query: 654  I--GQYLFTGSETTSLWLEVMETSGEEVICFVKNTATLSGPIFTLHVSQVHISMPTLSEY 827
            +  G+  F    T    +  +       +   ++   + G           I + T+++ 
Sbjct: 110  MSDGEVSFEVESTDPFTIRALNDG----VLRDRSRVNIPGRF---------IELGTITDR 156

Query: 828  DKQVISTWGLDNSVDIISLSHTRSSEDVRELRAFLQSHNLQDTQIYAKIENAEGLEHFDE 1007
            D+  I   G+ + VD  +LS  + SE+V  LR F+      D  I +KIE   GL++ +E
Sbjct: 157  DRAFIRE-GIADGVDFFALSFVQKSENVDSLRDFVIDSG-GDQYIISKIETKSGLDNIEE 214

Query: 1008 ILQEADGIIISRGDLGIDLPPERVFMSQKTGIHKCNMAGK-PVIITRVVDSMIDNLRPTR 1184
            I++ +DGI+++RGDLG++LP + V ++QK  I   +  G   ++ T+V++SM++N  PTR
Sbjct: 215  IVKSSDGIMVARGDLGVELPLKEVVLAQKHIIKTAHEDGDFTIVATQVLESMVNNSSPTR 274

Query: 1185 AEATDVANAVLDGTDGILLGAETLRGQYPVDAVSTVGRIC--AEAETVYNQSLHFKKVVR 1358
            AE +D+ NA++D  D ++L  E+  G+YPV AV T+  +    E +  ++ S +FK    
Sbjct: 275  AEISDITNAIIDNADALMLSEESAIGKYPVQAVRTLKEVSDYVEDKVSFDSSYYFK---- 330

Query: 1359 HVGEPMAHEEXXXXXXXXXXXXXXXXXIVVFTFSGRAARLVAKYRPPMPVLA 1514
              G  +A+                   IV  T +G   R+++  RP   V A
Sbjct: 331  --GNTIAYS--VARAAKILSDDIKSDGIVALTHTGSTVRMISSLRPKAMVYA 378

---

>P47458:KPYK_MYCGE Pyruvate kinase - Mycoplasma genitalium|
          Length = 508

 Score =  152 bits (384), Expect = 5e-36
 Identities = 105/333 (31%), Positives = 177/333 (53%), Gaps = 4/333 (1%)
 Frame = +3

Query: 342  IEECLTAGMSVARFDFSWKDATYHQETLDNLRKAAQNVKKLCPIMLDTVGPEIQVHNPTG 521
            IE  + +G+SV R +FS       Q  +  +R  A+ +     IMLDT GPEI++     
Sbjct: 44   IEAIIKSGVSVIRLNFSHGTHEEQQVRIKIVRDVAKAMNIPVSIMLDTNGPEIRIVETKK 103

Query: 522  GAIELIGGNHVTITPDLSKAPSADILPIKFGDLAKVVKKGDTLFIGQYLFTGSETTSLWL 701
              +++   + V I   +SK  ++D       D +      + + IGQ +       +L +
Sbjct: 104  EGLKITKDSEVIINT-MSKMIASDN-QFAVSDASGKYNMVNDVNIGQKILVDDGKLTLVV 161

Query: 702  EVMETSGEEVICFVKNTATLSGPIFT---LHVSQVHISMPTLSEYDKQVISTWGLDNSVD 872
              ++    +VIC  KN  T    +FT   L++     S+P LSE D + I  +GL   +D
Sbjct: 162  TRVDKQHNQVICVAKNDHT----VFTKKRLNLPNAQYSIPFLSEKDLKDID-FGLSQGID 216

Query: 873  IISLSHTRSSEDVRELRAFLQSHNLQDTQIYAKIENAEGLEHFDEILQEADGIIISRGDL 1052
             I+ S   +  D+++LR +L+  N    +I AKIE+   L + D+I++ +DGI+++RGDL
Sbjct: 217  YIAASFVNTVADIKQLRDYLKLKNASGVKIIAKIESNHALNNIDKIIKASDGIMVARGDL 276

Query: 1053 GIDLPPERVFMSQKTGIHKCNMAGK-PVIITRVVDSMIDNLRPTRAEATDVANAVLDGTD 1229
            G+++P  +V   Q+  I  C    K  +  T+++DS+  N++PTRAE TDV  AV  G D
Sbjct: 277  GLEIPYYQVPYWQRYMIKACRFFNKRSITATQMLDSLEKNIQPTRAEVTDVYFAVDRGND 336

Query: 1230 GILLGAETLRGQYPVDAVSTVGRICAEAETVYN 1328
              +L  ET  G YP++AV+ + +I  ++ET ++
Sbjct: 337  ATMLSGETASGLYPLNAVAVMQKIDKQSETFFD 369

---

>O05118:KPYK_METEX Pyruvate kinase - Methylobacterium extorquens (Protomonas extorquens)|
          Length = 483

 Score =  151 bits (381), Expect = 1e-35
 Identities = 122/417 (29%), Positives = 202/417 (48%), Gaps = 4/417 (0%)
 Frame = +3

Query: 294  TKIVGTLGPNSHSVEVIEECLTAGMSVARFDFSWKDATYHQETLDNLRKAAQNVKKLCPI 473
            TKIV TLGP S + E+IE+   AG  V R + S        E ++ +R   +  K+   I
Sbjct: 12   TKIVATLGPASDTPEMIEKLFHAGADVFRINMSHLAREKLPERIEVIRTIEREGKRPIGI 71

Query: 474  MLDTVGPEIQVHNPTGGAIELIGGNHVTITPDLSKAPSADILPIKFGDLAKVVKKGDTLF 653
            ++D  GP++++    G A  L  G    +  D +   + D + +   ++   ++    + 
Sbjct: 72   LVDLQGPKLRLGTFVGDAAVLENGQTFVLDSDPTPGDT-DRVFLPHPEILSALEPSHGIL 130

Query: 654  IGQYLFTGSETTSLWLEVMETSGEEVICFVKNTATLSGPIFTLHVSQVHISMPT--LSEY 827
            I        +   L L V E S    +  V+    +S       VS  H ++P   ++E 
Sbjct: 131  I--------DDGKLRLIVTEVSEGRAVTRVEVGGRISN---RKGVSLPHTALPVPAMTEK 179

Query: 828  DKQVISTWGLDNSVDIISLSHTRSSEDVRELRAFLQSHNLQDTQIYAKIENAEGLEHFDE 1007
            D+  +   GL    D I++S  +  EDV E++       L    + AKIE  + L   DE
Sbjct: 180  DRGDLEA-GLAAGADWIAVSFVQRPEDVAEVKKVAAGRAL----VMAKIEKPQALTRLDE 234

Query: 1008 ILQEADGIIISRGDLGIDLPPERVFMSQKTGIHKCNMAGKPVII-TRVVDSMIDNLRPTR 1184
            I++ +DGI+++RGDLG+++P E+V   QK         GKPV++ T++++SMI +  PTR
Sbjct: 235  IIEISDGIMVARGDLGVEMPLEQVPGVQKRITRVARRLGKPVVVATQMLESMITSPVPTR 294

Query: 1185 AEATDVANAVLDGTDGILLGAETLRGQYPVDAVSTVGRICAEAETVYNQSLHFKKVVRHV 1364
            AE +DVA AV +G D ++L AE+  G +PV+A+ T+ RI   AE V   +L++  ++   
Sbjct: 295  AEVSDVATAVYEGADAVMLSAESAAGDFPVEAIGTMNRI---AEQVERDALYWSILMAQR 351

Query: 1365 GEP-MAHEEXXXXXXXXXXXXXXXXXIVVFTFSGRAARLVAKYRPPMPVLAVVFPRE 1532
             EP     +                 I+ +T SG     +A+ RP   V+A+   RE
Sbjct: 352  SEPEPTASDAIAAAAHQIVEALSLRSIMAWTHSGSTVLRLARARPNASVIALTPKRE 408

---

>Q43117:KPYA_RICCO Pyruvate kinase isozyme A, chloroplast precursor - Ricinus communis|
            (Castor bean)
          Length = 583

 Score =  150 bits (379), Expect = 2e-35
 Identities = 112/421 (26%), Positives = 205/421 (48%), Gaps = 14/421 (3%)
 Frame = +3

Query: 294  TKIVGTLGPNSHSVEVIEECLTAGMSVARFDFSWKDATYHQETLDNLRKAAQNVKKLCPI 473
            TK+V T+GP +   E +E     GM+VAR +       +H+  ++ +R+  +       I
Sbjct: 106  TKLVCTIGPATCGFEELEALAVGGMNVARINMCHGTREWHKSVIERVRRLNEEKGFAVAI 165

Query: 474  MLDTVGPEIQVHNPTGGA-IELIGGNHVTITPDLSKAPSAD-ILPIKFGDLAKVVKKGDT 647
            M+DT G EI + +  G +  +   G   T +     +P  +  + + +   A+ VK GD 
Sbjct: 166  MMDTEGSEIHMGDLGGASSAKAEDGEIWTFSVRAYDSPRPERTINVNYDGFAEDVKVGDE 225

Query: 648  LFIGQYLFTGSETTSLWLEVMETSGEEVICFVKNTATLSGPIFTLH-------VSQVHIS 806
            L +        +   +  EV+E  G +V C   +   L  P   L        V + +  
Sbjct: 226  LLV--------DGGMVRFEVIEKIGPDVKCRCTDPGLLL-PRANLTFWRDGSLVRERNAM 276

Query: 807  MPTLSEYDKQVISTWGLDNSVDIISLSHTRSSEDVRELRAFLQSHNLQ-DTQIYAKIENA 983
            +PT+S  D   I  +G+   VD I++S  +S+E +  L++++ + +   D  + AKIE+ 
Sbjct: 277  LPTISSKDWLDID-FGIAEGVDFIAISFVKSAEVINHLKSYIAARSRDSDIAVIAKIESI 335

Query: 984  EGLEHFDEILQEADGIIISRGDLGIDLPPERVFMSQKTGIHKCNMAGKPVII-TRVVDSM 1160
            + L++ +EI++ +DG +++RGDLG  +P E+V  +Q+  +  C    KPVI+ +++++SM
Sbjct: 336  DSLKNLEEIIRASDGAMVARGDLGAQIPLEQVPSAQQNIVQVCRQLNKPVIVASQLLESM 395

Query: 1161 IDNLRPTRAEATDVANAVLDGTDGILLGAETLRGQYPVDAVSTVGRICAEAETVYNQSLH 1340
            I+   PTRAE  DV+ AV    D ++L  E+  GQYP  A++ +  +    E  + +  H
Sbjct: 396  IEYPTPTRAEVADVSEAVRQRADALMLSGESAMGQYPEKALAVLRSVSVRIEKWWREEKH 455

Query: 1341 FKKV-VRHVGEPMAH--EEXXXXXXXXXXXXXXXXXIVVFTFSGRAARLVAKYRPPMPVL 1511
             + + +  +G   +    E                 + V+T  G  A L+++ RP  P+ 
Sbjct: 456  HEAMELPAIGSTYSDSISEEICNSAAKMANNLGVDALFVYTKDGHMASLLSRCRPDCPIF 515

Query: 1512 A 1514
            A
Sbjct: 516  A 516

---

>Q40545:KPYA_TOBAC Pyruvate kinase isozyme A, chloroplast precursor - Nicotiana tabacum|
            (Common tobacco)
          Length = 593

 Score =  145 bits (367), Expect = 5e-34
 Identities = 109/424 (25%), Positives = 202/424 (47%), Gaps = 17/424 (4%)
 Frame = +3

Query: 294  TKIVGTLGPNSHSVEVIEECLTAGMSVARFDFSWKDATYHQETLDNLRKAAQNVKKLCPI 473
            TK++ T+GP +   E +E     GM+VAR +       +H+  ++ LR+  +       I
Sbjct: 116  TKLICTIGPATCGFEQLERLAEGGMNVARINMCHGTREWHRMVIERLRRLNEEKGFAVAI 175

Query: 474  MLDTVGPEIQVHNPTGGAIELIGGNHV---TITPDLSKAPSADILPIKFGDLAKVVKKGD 644
            M+DT G EI + +  G +        +   T+       P   +  + +   A+ VK GD
Sbjct: 176  MMDTEGSEIHMGDLGGASSAKAEDGEIWNFTVRSFDPPLPERTVT-VNYDGFAEDVKVGD 234

Query: 645  TLFIGQYLFTGSETTSLWLEVMETSGEEVICFVKNTATLSGPIFTLH-------VSQVHI 803
             L +        +   +  EV+E  G +V C   +   L  P   L        V + + 
Sbjct: 235  ELLV--------DGGMVRFEVIEKIGPDVKCLCTDPGLLL-PRANLTFWRDGKLVRERNA 285

Query: 804  SMPTLSEYDKQVISTWGLDNSVDIISLSHTRSSEDVRELRAFLQSHNLQ-DTQIYAKIEN 980
             +PT+S  D   I  +G+   VD I++S  +S+E ++ L++++Q+     D  + AKIE+
Sbjct: 286  MLPTISSKDWLDID-FGIAEGVDFIAVSFVKSAEVIKHLKSYIQARARDSDISVIAKIES 344

Query: 981  AEGLEHFDEILQEADGIIISRGDLGIDLPPERVFMSQKTGIHKCNMAGKPVII-TRVVDS 1157
             + L++ +EI+Q +DG +++RGDLG  +P E+V   Q+  +  C    +PVI+ +++++S
Sbjct: 345  IDSLKNLEEIIQASDGAMVARGDLGAQIPLEQVPSEQQKIVQICRQLNRPVIVASQLLES 404

Query: 1158 MIDNLRPTRAEATDVANAVLDGTDGILLGAETLRGQYPVDAVSTVGRICAEAETVYNQS- 1334
            MI+   PTRAE  DV+ AV    D ++L  E+  GQ+P  A++ +  +    E ++ +  
Sbjct: 405  MIEYPIPTRAEVADVSEAVRQRGDALMLSGESAMGQFPEKALTVLRSVSLRIERMWREQK 464

Query: 1335 ----LHFKKVVRHVGEPMAHEEXXXXXXXXXXXXXXXXXIVVFTFSGRAARLVAKYRPPM 1502
                +    +     + ++ E                  + V+T +G  A L+++ RP  
Sbjct: 465  RHEVIELPSIASSFSDSISEE--ICNSAAKMANNLEVDALFVYTKNGHMASLLSRCRPDC 522

Query: 1503 PVLA 1514
            P+ A
Sbjct: 523  PIFA 526

---

>P57404:KPYK_BUCAI Pyruvate kinase - Buchnera aphidicola subsp. Acyrthosiphon pisum|
            (Acyrthosiphon pisum symbiotic bacterium)
          Length = 480

 Score =  144 bits (362), Expect = 2e-33
 Identities = 115/413 (27%), Positives = 203/413 (49%), Gaps = 5/413 (1%)
 Frame = +3

Query: 294  TKIVGTLGPNSHSVEVIEECLTAGMSVARFDFSWKDATYHQETLDNLRKAAQNVKKLCPI 473
            TKIV TLGP++     +E+ + +G++V RF+FS      H+   +  R+    +     +
Sbjct: 8    TKIVATLGPSTDINNNLEKIIRSGVNVLRFNFSHGSKDEHKSRANQAREIMTRLNFHIAL 67

Query: 474  MLDTVGPEIQVHNPTGGAIELIGGNHVTITPDLSKAP-SADILPIKFGDLAKVVKKGDTL 650
            + D  GP+I++       I L  G+   +  +L +   + + + I +  L   +K GD L
Sbjct: 68   LGDLQGPKIRISKFIKNNIFLNVGDFFILDANLDQNNGNQERVGIDYKQLPYDLKVGDVL 127

Query: 651  FIGQYLFTGSETTSLWLEVMETSGEEVICFVKNTATLSGPIFTLHVSQVHISMPTLSEYD 830
             +        +   + L+V++++G E++  V     LS     ++     +S   L+E D
Sbjct: 128  LL--------DDGRIQLKVIKSTGHEILTKVVIGGILSNNK-GINKLGGGLSADALTEKD 178

Query: 831  KQVISTWGLDNSVDIISLSHTRSSEDVRELRAFLQSHNLQDTQIYAKIENAEGLEH---F 1001
            K+ I     + +VD +++S  R S D+++ R   +     + +I AKIE AE + +    
Sbjct: 179  KKDIIL-ATEINVDYLAISFPRCSNDLKQARKLAKEFG-SNAKIIAKIERAEAVLNQNTI 236

Query: 1002 DEILQEADGIIISRGDLGIDLPPERVFMSQKTGIHKCNMAGKPVII-TRVVDSMIDNLRP 1178
            ++I+  +D I+I+RGDLG+++    +   QK  I       + VI  T++++SMI N  P
Sbjct: 237  EDIILASDAIMIARGDLGVEIGDSELAGIQKKLIRTARQLNRIVITATQMMESMITNPLP 296

Query: 1179 TRAEATDVANAVLDGTDGILLGAETLRGQYPVDAVSTVGRICAEAETVYNQSLHFKKVVR 1358
            TRAE  DVANAVLDG+D ++L AET  G+YP + V  + +IC  AE V   S++  +   
Sbjct: 297  TRAEVMDVANAVLDGSDAVMLSAETASGEYPAETVIKMAKICKGAEKV--PSINVSRHRI 354

Query: 1359 HVGEPMAHEEXXXXXXXXXXXXXXXXXIVVFTFSGRAARLVAKYRPPMPVLAV 1517
            H       E                  I+  T SG+ A + ++    +P+ A+
Sbjct: 355  HAKFDDIEEAIAMSAMYVANHLKGITAIITMTESGKTALMTSRITSGLPIFAL 407

---

>Q57572:KPYK_METJA Pyruvate kinase - Methanococcus jannaschii|
          Length = 447

 Score =  143 bits (360), Expect = 3e-33
 Identities = 116/413 (28%), Positives = 202/413 (48%), Gaps = 6/413 (1%)
 Frame = +3

Query: 294  TKIVGTLGPNSHSVEVIEECLTAGMSV---ARFDFSWKDATYHQETLDNLRKAAQNVKKL 464
            TKI+ TLGP+      +E  L   +++    RF+ S     Y ++ L+ L K   N+ K+
Sbjct: 8    TKILVTLGPS------LENKLDKAINLIDGVRFNMSHATTDYCEKFLNILEK--NNIAKV 59

Query: 465  CPIMLDTVGPEIQVHNPTGGAIELIGGNHVTITPDLSKAPSADILPIKFGDLAKVVKKGD 644
                +D  G +I++         L  G  V I  D+    + D            +++G 
Sbjct: 60   ----MDLKGIKIRIKEVKLKNKILKMGEKVVIGEDIKLNYNID-----------TIEEGH 104

Query: 645  TLFI--GQYLFTGSETTSLWLEVMETSGEEVICFVKNTATLSGPIFTLHVSQVHISMPTL 818
             + I  G+      E T   + V+E  GE     +K    ++ P          I +P +
Sbjct: 105  FILINDGKIKLRVVEKTDKIIAVVEVGGE-----IKEGMGVNLP-------DTRIELPII 152

Query: 819  SEYDKQVISTWGLDNSVDIISLSHTRSSEDVRELRAFLQSHNLQDTQIYAKIENAEGLEH 998
             E D + I  + ++   + I+LS  R+ EDV+EL+  +  +   D ++ +KIE  EGL++
Sbjct: 153  DETDLKNIK-FAVEKDFEYIALSFVRNKEDVKELKDIISEYK-GDCEVISKIETKEGLKN 210

Query: 999  FDEILQEADGIIISRGDLGIDLPPERVFMSQKTGIHKCNMAG-KPVIITRVVDSMIDNLR 1175
              EI +E+DG++++RGDLG+++P E + + QK  +   N  G   +  T+++DSMI+N  
Sbjct: 211  IKEIARESDGVMVARGDLGVEVPIENIPIEQKNILRIANRYGILSITATQILDSMINNPF 270

Query: 1176 PTRAEATDVANAVLDGTDGILLGAETLRGQYPVDAVSTVGRICAEAETVYNQSLHFKKVV 1355
            PTRAE TD+ANA+ DGTD ++L  ET  G+YP++A+  + ++   A+  Y +        
Sbjct: 271  PTRAEVTDIANAIYDGTDCLMLSNETTIGKYPIEAIKVLNKVAKVADEHYEEFGD----- 325

Query: 1356 RHVGEPMAHEEXXXXXXXXXXXXXXXXXIVVFTFSGRAARLVAKYRPPMPVLA 1514
            R   E  + +E                 ++  T+SGR A+L++K R    ++A
Sbjct: 326  RVCLEVESIDEGLVYAVYELYKKLNTKLVITPTYSGRTAKLISKLRINSKIIA 378

---

>Q89AI8:KPYK_BUCBP Pyruvate kinase - Buchnera aphidicola subsp. Baizongia pistaciae|
          Length = 479

 Score =  139 bits (349), Expect = 6e-32
 Identities = 112/413 (27%), Positives = 203/413 (49%), Gaps = 5/413 (1%)
 Frame = +3

Query: 294  TKIVGTLGPNSHSVEVIEECLTAGMSVARFDFSWKDATYHQETLDNLRKAAQNVKKLCPI 473
            TKIV TLGP++ +  ++E  + +G++V R +FS      H      +   A+ +     +
Sbjct: 8    TKIVATLGPSTDNHIILENMIKSGVNVFRLNFSHGTREEHIYRAKLVTSIAKRLNCHIAL 67

Query: 474  MLDTVGPEIQVHNPTGGAIELIGGNHVTITPDLSK-APSADILPIKFGDLAKVVKKGDTL 650
            + D  GP+I++       + L   N+  +  +L++   +++ + I + +L K VKK D L
Sbjct: 68   LGDLQGPKIRICKFQDKKVFLKVNNYFILDANLNENLGTSERVGIDYKNLPKDVKKCDIL 127

Query: 651  FIGQYLFTGSETTSLWLEVMETSGEEVICFVKNTATLSGPIFTLHVSQVHISMPTLSEYD 830
             +        +   + L+V+    +E+   +     LS     ++     +S   L++ D
Sbjct: 128  LL--------DDGKIQLKVINIVDQEIFTKIIIGGVLSNNK-GINKLGGGLSARILTKKD 178

Query: 831  KQVISTWGLDNSVDIISLSHTRSSEDVRELRAFLQSHNLQDTQIYAKIENAEG---LEHF 1001
            K+ I T  +D  VD +++S  R   D+   R        +  +I AKIE AE    L+  
Sbjct: 179  KRDIIT-SIDIGVDYLAVSFPRYGSDLDHARKCAVKFGSK-AKIIAKIERAEAVKDLKII 236

Query: 1002 DEILQEADGIIISRGDLGIDLPPERVFMSQKTGIHKCNMAGKPVII-TRVVDSMIDNLRP 1178
            DEI+  +D I+++RGDLG+++    +   QKT I +     + VI  T++++SMI+N  P
Sbjct: 237  DEIILASDAIMVARGDLGVEIGESELAGIQKTLIRRARQLNRVVITATQMMESMINNPMP 296

Query: 1179 TRAEATDVANAVLDGTDGILLGAETLRGQYPVDAVSTVGRICAEAETVYNQSLHFKKVVR 1358
            TRAE  DVANAVLDG+D ++L AET  G+YP++ +  + ++C  AE +   S++  +   
Sbjct: 297  TRAEVMDVANAVLDGSDAVMLSAETASGKYPIETIKVMSKVCMGAEKM--PSINVSQHRI 354

Query: 1359 HVGEPMAHEEXXXXXXXXXXXXXXXXXIVVFTFSGRAARLVAKYRPPMPVLAV 1517
            H       E                  I+  T SG+ + + ++    +P+ A+
Sbjct: 355  HDKFHDIEEAIAMSAMYAANHLSGITAIITMTESGKTSLMTSRITSGLPIFAL 407

---

>P55964:KPYG_RICCO Pyruvate kinase isozyme G, chloroplast - Ricinus communis (Castor|
            bean)
          Length = 418

 Score =  136 bits (343), Expect = 3e-31
 Identities = 104/362 (28%), Positives = 180/362 (49%), Gaps = 5/362 (1%)
 Frame = +3

Query: 444  AQNVKKLCPIMLDTVGPEIQVHNPTGGAIELIGGNHVTITPDLSKAPSA-DILPIKFGDL 620
            AQ+   +  IMLDT GPE++    +G   + +        P + +  S  D + + + D 
Sbjct: 2    AQSHDNVVSIMLDTKGPEVR----SGDVPQPMLKEGQEFNPTIRRGVSTQDTVSVNYDDF 57

Query: 621  AKVVKKGDTLFIGQYLFTGSETTSLWLEVMETSGEEVICFVKNTATLSGPIFTLHVSQVH 800
               V  GD L +   + +        L V   + + V C V +   L      L+V    
Sbjct: 58   VNDVVVGDILLVDGGMMS--------LAVKSKTSDLVKCVVVDGGELKSRRH-LNVRGKS 108

Query: 801  ISMPTLSEYDKQVISTWGLDNSVDIISLSHTRSSEDVRELRAFLQSHNLQDTQIYAKIEN 980
              +P++++ D   I  +G+DN VD  ++S  + ++ V EL+ +L+  N  D  +  KIE+
Sbjct: 109  ARLPSITDKDWGDIK-FGVDNQVDFYAVSFVKDAKVVHELKEYLKRCNA-DIHVIVKIES 166

Query: 981  AEGLEHFDEILQEADGIIISRGDLGIDLPPERVFMSQKTGIHKCNMAGKPVII-TRVVDS 1157
            A+ + +   I+  +DG +++RGDLG +LP E V + Q+  I +C+   KPVI+ T +++S
Sbjct: 167  ADSIPNLHSIISASDGAMVARGDLGAELPIEEVPLLQEDIIRRCHSMQKPVIVATNMLES 226

Query: 1158 MIDNLRPTRAEATDVANAVLDGTDGILLGAETLRGQYPVDAVSTVGRIC--AEAETVYNQ 1331
            MI++  PTRAE +D+A AV +G D ++L  ET  G+YP+ AV  +  +    E+ +  N 
Sbjct: 227  MINHPTPTRAEVSDIAIAVREGADAVMLSGETAHGKYPLKAVRVMHTVALRTESSSPVNT 286

Query: 1332 SLHFKKVVR-HVGEPMAHEEXXXXXXXXXXXXXXXXXIVVFTFSGRAARLVAKYRPPMPV 1508
            +   +   + H+GE  A                    I+VFT +G  A L++ Y+P   +
Sbjct: 287  TPPAQGAYKGHMGEMFAFH-------ATIMANTLNTPIIVFTRTGSMAVLLSHYQPASTI 339

Query: 1509 LA 1514
             A
Sbjct: 340  FA 341

---

>Q9YEU2:KPYK_AERPE Pyruvate kinase - Aeropyrum pernix|
          Length = 458

 Score =  132 bits (333), Expect = 4e-30
 Identities = 98/340 (28%), Positives = 167/340 (49%), Gaps = 1/340 (0%)
 Frame = +3

Query: 297  KIVGTLGPNSHSVEVIEECLTAGMSVARFDFSWKDATYHQETLDNLRKAAQNVKKLCPIM 476
            KIV T+GP+S S  ++ + L+ G+ VAR + S          L++LR+A + V K   + 
Sbjct: 6    KIVATVGPSSSSASILAQMLSLGVDVARINASHGGVEQWNSMLESLRRAEEAVGKRVGVA 65

Query: 477  LDTVGPEIQVHNPTGGAIELIGGNHVTITPDLSKAPSADILPIKFGDLAKVVKKGDTLFI 656
            +D  GP ++  N     ++L  G+ VT+          D+ P+      + + +GD + +
Sbjct: 66   VDLEGPRVRTGNSE--PVKLEKGDLVTLG-----FMEGDV-PVDARQFFETIDEGDIVLL 117

Query: 657  GQYLFTGSETTSLWLEVMETSGEEVICFVKNTATLSGPIFTLHVSQVHISMPTLSEYDKQ 836
                    +   + L+V    G  V   V     L GP   + V      +P LS  D++
Sbjct: 118  --------DDGKIILQVESVEGFRVKARVLEGGVL-GPRKGVVVRGKEPDLPPLSAKDRR 168

Query: 837  VISTWGLDNSVDIISLSHTRSSEDVRELRAFLQSHNLQDTQIYAKIENAEGLEHFDEILQ 1016
             +  +  D  V  + +S  RS+E V ++R  ++   L+  +I+AKIE   G+    EI +
Sbjct: 169  ALEFFA-DKGVSHVYVSFARSAEHVEKVRTVVRRLGLRQARIFAKIEGPSGVSRIGEIAE 227

Query: 1017 EADGIIISRGDLGIDLPPERVFMSQKTGIHKCNMAGKPVII-TRVVDSMIDNLRPTRAEA 1193
             +DG+II+RGDLG+    E +   Q+  + +     K V++ T  + SMI+   PTR+E 
Sbjct: 228  ASDGVIIARGDLGMHYSLEELPEIQELIVWEARKRYKTVVLATEFLSSMIEKPVPTRSEV 287

Query: 1194 TDVANAVLDGTDGILLGAETLRGQYPVDAVSTVGRICAEA 1313
             D+  AVL   D ++L  ET  G+YPV +V  + +I + A
Sbjct: 288  VDIYQAVLQTADALMLTGETAIGKYPVKSVQWMAKISSRA 327

---

>Q8K9M3:KPYK_BUCAP Pyruvate kinase - Buchnera aphidicola subsp. Schizaphis graminum|
          Length = 481

 Score =  127 bits (319), Expect = 2e-28
 Identities = 118/420 (28%), Positives = 204/420 (48%), Gaps = 12/420 (2%)
 Frame = +3

Query: 294  TKIVGTLGPNSHSVEVIEECLTAGMSVARFDFSWKDATYHQETLDNLRKAAQNVKKL-CP 470
            TKIV TLGP++     +E+ + +G +V R +FS   +  H++     +KA + + KL C 
Sbjct: 8    TKIVATLGPSTDKANNLEKIILSGANVLRLNFSHGSSEEHKK---RAKKAKEIMFKLNCH 64

Query: 471  IML--DTVGPEIQVHNPTGGAIELIGGNHVTITPDLS-KAPSADILPIKFGDLAKVVKKG 641
            I L  D  GP+I++      +I L   +   +  +L+ K  + + + I +  L   +   
Sbjct: 65   IALLGDLQGPKIRISKFKKNSIFLKVNDVFILDANLNEKNGNNERVGIDYKKLPNDLNVN 124

Query: 642  DTLFIGQYLFTGSETTSLWLEVMETSGEEVICFVKNTATLSGPIFT----LHVSQVHISM 809
            D L +        +   + L+V++   E+   F K    + G I +    ++     +S 
Sbjct: 125  DILLL--------DDGRIQLKVIKI--EKCAIFTK---VIIGGILSNNKGINKLGGGLSA 171

Query: 810  PTLSEYDKQVISTWGLDNSVDIISLSHTRSSEDVRELRAFLQSHNLQDTQIYAKIENAEG 989
              L+E DK+ I     +  VD +++S  R ++D+ + R  L+     + QI AKIE AE 
Sbjct: 172  DALTEKDKKDIIL-ASEIDVDYLAVSFPRCADDLIKARELLKKSG-SNAQIIAKIERAEA 229

Query: 990  L---EHFDEILQEADGIIISRGDLGIDLPPERVFMSQKTGIHKCNMAGKPVII-TRVVDS 1157
            +      + I+  +D I+I+RGDLG+++    +   QK  I       K  I  T++++S
Sbjct: 230  VFDQNAIENIILSSDAIMIARGDLGVEIGDAELVGIQKKLIRTARKLNKVAITATQMMES 289

Query: 1158 MIDNLRPTRAEATDVANAVLDGTDGILLGAETLRGQYPVDAVSTVGRICAEAETVYNQSL 1337
            MI N  PTRAE  DVANAVLDG+D ++L AET  G+YP + V ++ ++C  AE V   S+
Sbjct: 290  MILNPLPTRAEVMDVANAVLDGSDAVMLSAETASGKYPSETVISMAKVCKGAEKV--PSI 347

Query: 1338 HFKKVVRHVGEPMAHEEXXXXXXXXXXXXXXXXXIVVFTFSGRAARLVAKYRPPMPVLAV 1517
            +  +   +V      E                  I+  T SG+ A + ++    +P+ A+
Sbjct: 348  NVSRHRLNVEFQSIEEAIAMSSMYAANHLKGITAIITMTESGKTALMTSRITSGLPIFAL 407

---

>O30853:KPYK1_PHOLE Pyruvate kinase I - Photobacterium leiognathi|
          Length = 235

 Score =  124 bits (312), Expect = 1e-27
 Identities = 83/225 (36%), Positives = 122/225 (54%), Gaps = 1/225 (0%)
 Frame = +3

Query: 1020 ADGIIISRGDLGIDLPPERVFMSQKTGIHKCNMAGKPVII-TRVVDSMIDNLRPTRAEAT 1196
            +DGI+++RGDLG+++P E V  +QK  I KCN A K VI  T+++DSMI N RPTRAEA 
Sbjct: 2    SDGIMVARGDLGVEIPVEEVIFAQKMMIEKCNRARKVVITATQMLDSMIKNPRPTRAEAG 61

Query: 1197 DVANAVLDGTDGILLGAETLRGQYPVDAVSTVGRICAEAETVYNQSLHFKKVVRHVGEPM 1376
            DVANA++DGTD ++L  E+ +G+YP++AV+ + +ICA  + V    L      R     +
Sbjct: 62   DVANAIMDGTDAVMLSGESAKGKYPIEAVTIMAQICARTDDVVKPELG----SRLDSPRL 117

Query: 1377 AHEEXXXXXXXXXXXXXXXXXIVVFTFSGRAARLVAKYRPPMPVLAVVFPREGSDPSKWR 1556
               E                 I+V T +G++AR V KY P   +LAV             
Sbjct: 118  RITEAVCKGAVDTAEKLNAPLIIVATEAGKSARSVRKYFPTARILAVT------------ 165

Query: 1557 SYGTTQARQCFSVRGVYPLMGSTDEAETGGLTKEAYGIKLALNYG 1691
            +   T A+ C S +GV P++  + E+      +   G +LAL  G
Sbjct: 166  TNTKTAAQLCLS-KGVTPVVVDSIESTDAFYLR---GKELALETG 206

---

>Q8ZYE0:KPYK_PYRAE Pyruvate kinase - Pyrobaculum aerophilum|
          Length = 461

 Score =  108 bits (271), Expect = 7e-23
 Identities = 106/412 (25%), Positives = 183/412 (44%), Gaps = 9/412 (2%)
 Frame = +3

Query: 288  SLTKIVGTLGPNSHSVEVIEEC----LTAGMSVARFDFSWKDATYHQETLDNLRKAAQNV 455
            +LTK V TLGP++  +   E      L  G+ +     S  +  +  E + +  KA    
Sbjct: 15   NLTKRVATLGPSTDVLRPDELIKFLDLVDGVRINLAHASPNEVKFRIEAVRSYEKAKN-- 72

Query: 456  KKLCPIMLDTVGPEIQVHNPTGGAIELIGGNHVTITPDLSKAPSADILPIKFGDLAKVVK 635
             +   +++D  GP I+V + +   I +  G  V     LS       +P+        V+
Sbjct: 73   -RPLAVIVDLKGPSIRVGSTS--PINVQEGEVVKFK--LSDKSDGTYIPVPNKAFFSAVE 127

Query: 636  KGDTLFI--GQYLFTGSETTSLWLE-VMETSGEEVICFVKNTATLSGPIFTLHVSQVHIS 806
            + D + +  G+     + T S W+E V E+SG              G    +      IS
Sbjct: 128  QNDVILMLDGRLRLKVTNTGSDWIEAVAESSG----------VITGGKAIVVEGKDYDIS 177

Query: 807  MPTLSEYDKQVISTWG-LDNSVDIISLSHTRSSEDVRELRAFLQSHNLQDTQIYAKIENA 983
             P  +E D + +     + +++D +++S  +S +DV  +R+ L     Q +Q+  KIE  
Sbjct: 178  TP--AEEDVEALKAISPIRDNIDYVAISLAKSCKDVDSVRSLLTELGFQ-SQVAVKIETK 234

Query: 984  EGLEHFDEILQEADGIIISRGDLGIDLPPERVFMSQKTGIHKCNMAGKPVII-TRVVDSM 1160
              + + +E++Q +D ++++RGDLG+    + + + Q+  +H     GKP+ + T+++DSM
Sbjct: 235  GAVNNLEELVQCSDYVVVARGDLGLHYGLDALPIVQRRIVHTSLKYGKPIAVATQLLDSM 294

Query: 1161 IDNLRPTRAEATDVANAVLDGTDGILLGAETLRGQYPVDAVSTVGRICAEAETVYNQSLH 1340
              +  PTRAE  DV      G D + L  ET  G+YP+ AVS + RI    E    QS  
Sbjct: 295  QSSPIPTRAEINDVFTTASMGVDSLWLTNETASGKYPLAAVSWLSRILMNVEYQIPQS-- 352

Query: 1341 FKKVVRHVGEPMAHEEXXXXXXXXXXXXXXXXXIVVFTFSGRAARLVAKYRP 1496
                       + +                   I+VF+ SG  AR +AK+RP
Sbjct: 353  ---------PLLQNSRDRFAKGLVELAQDLGANILVFSMSGTLARRIAKFRP 395

---

>Q56301:KPYK_THELI Pyruvate kinase - Thermococcus litoralis|
          Length = 220

 Score = 94.4 bits (233), Expect = 2e-18
 Identities = 64/217 (29%), Positives = 116/217 (53%), Gaps = 3/217 (1%)
 Frame = +3

Query: 294 TKIVGTLGPNSHSVEVIEECLTAGMSVARFDFSWKDATYHQETLDNLRKAAQNVKKLCPI 473
           TKI+ T+GP S   E I++ + AGMSVAR +FS      H +T++ +R  A+ +++   I
Sbjct: 12  TKIIATIGPASKQKESIKKMIKAGMSVARINFSHGTLEEHAKTIETVRDVAEKLERRVAI 71

Query: 474 MLDTVGPEIQVHNPTGGAIELIGGNHVTITPDLSKAPSADILPIKFGDLAKVVKKGDTLF 653
           + D  G +++V    G ++ L  G+ V +T    +     I P++F DL K+V KGDT++
Sbjct: 72  LGDLPGLKMRVGKIKGDSVTLRKGDKVVLTTRDIEGDETTI-PVEFKDLPKLVSKGDTIY 130

Query: 654 IGQYLFTGSETTSLWLEVMETSGEEVICFVKNTATLSGPIFT---LHVSQVHISMPTLSE 824
           +            + L V E    EV C V N     G +F+   +++ + ++ +  ++ 
Sbjct: 131 LSD--------GYIMLRVEEVRENEVECVVVN----GGILFSHKGINIPKANLPIEAITP 178

Query: 825 YDKQVISTWGLDNSVDIISLSHTRSSEDVRELRAFLQ 935
            D ++I  + +++ VD I LS   S  DV ++++FL+
Sbjct: 179 RDFEIIE-FAIEHGVDAIGLSFVGSVYDVLKVKSFLE 214

---

>Q04668:KPYK_LEIBR Pyruvate kinase - Leishmania braziliensis|
          Length = 91

 Score = 63.2 bits (152), Expect = 4e-09
 Identities = 32/68 (47%), Positives = 46/68 (67%)
 Frame = +3

Query: 300 IVGTLGPNSHSVEVIEECLTAGMSVARFDFSWKDATYHQETLDNLRKAAQNVKKLCPIML 479
           IV T+GP++ SVE ++  + +GMSVAR +FS     YHQ T++N+R+AA  +     I L
Sbjct: 22  IVCTIGPSTQSVEALKGLIKSGMSVARMNFSHGSHEYHQTTINNVRQAAAELGVNIAIAL 81

Query: 480 DTVGPEIQ 503
           DT GPEI+
Sbjct: 82  DTKGPEIR 89

---

>P19680:KPYK_SPICI Pyruvate kinase - Spiroplasma citri|
          Length = 192

 Score = 50.4 bits (119), Expect = 3e-05
 Identities = 26/69 (37%), Positives = 38/69 (55%)
 Frame = +3

Query: 294 TKIVGTLGPNSHSVEVIEECLTAGMSVARFDFSWKDATYHQETLDNLRKAAQNVKKLCPI 473
           TKI+ T+GP++HS   IEE    GM+  R +FS  D       +   R+ +  + K   +
Sbjct: 13  TKIITTIGPSTHSPGAIEELFKTGMTTIRLNFSHGDHAEQGARIVWAREVSAKIGKPISV 72

Query: 474 MLDTVGPEI 500
           +LDT GPEI
Sbjct: 73  LLDTKGPEI 81

---

>Q7SAX8:FIP1_NEUCR Pre-mRNA polyadenylation factor fip-1 - Neurospora crassa|
          Length = 423

 Score = 37.7 bits (86), Expect = 0.20
 Identities = 26/97 (26%), Positives = 42/97 (43%), Gaps = 5/97 (5%)
 Frame = +3

Query: 1044 GDLGIDLPPERVFMSQKTGIHKCNMAGKPVIITRVVDSMIDNLRPTRAEATDVANAVLDG 1223
            G  G +LPP R    +  GI      GKP+    + + + +N +P R   TD+++    G
Sbjct: 167  GGSGAELPPVRTSKIEVDGIPVYKPVGKPITGVVIDEDLPENDKPWRKPGTDLSDYFNYG 226

Query: 1224 TDGILLG-----AETLRGQYPVDAVSTVGRICAEAET 1319
             D           E LRG+Y  +A++   +   E  T
Sbjct: 227  FDEFTWALYAQKQEALRGEYNAEAIAANNKKMMEEMT 263

---

>A0M574:RS4_GRAFK 30S ribosomal protein S4 - Gramella forsetii (strain KT0803)|
          Length = 201

 Score = 34.7 bits (78), Expect = 1.7
 Identities = 22/81 (27%), Positives = 38/81 (46%)
 Frame = +3

Query: 459 KLCPIMLDTVGPEIQVHNPTGGAIELIGGNHVTITPDLSKAPSADILPIKFGDLAKVVKK 638
           +LC   LD V   + V      A +L+G  H+T+  +L   PS     +K GD+  V +K
Sbjct: 89  QLCESRLDNVVYRMGVAPSRRAARQLVGHRHITVNGELVNIPS---YHLKAGDVVGVREK 145

Query: 639 GDTLFIGQYLFTGSETTSLWL 701
             +L + Q   + + +   W+
Sbjct: 146 SKSLAVVQESLSNNSSVYEWI 166

---

>P39737:YVYC_BACSU Uncharacterized protein yvyC - Bacillus subtilis|
          Length = 109

 Score = 34.3 bits (77), Expect = 2.2
 Identities = 22/100 (22%), Positives = 51/100 (51%), Gaps = 1/100 (1%)
 Frame = +3

Query: 780  LHVSQVHISMPTLSEYDKQVISTWGLDNSVDIISLSHTRSSEDVRELRAFLQSHNLQDTQ 959
            +++ ++    P    YD Q+ +    DN V +  +S+T  +E V E+        L+ +Q
Sbjct: 1    MNIERLTTLQPVWDRYDTQIHNQKDNDNEVPVHQVSYTNLAEMVGEMNKL-----LEPSQ 55

Query: 960  IYAKIENAEGL-EHFDEILQEADGIIISRGDLGIDLPPER 1076
            ++ K E  + L E++ ++++++   +I       ++PP+R
Sbjct: 56   VHLKFELHDKLNEYYVKVIEDSTNEVIR------EIPPKR 89

---

>Q9NU02:ANKR5_HUMAN Ankyrin repeat domain-containing protein 5 - Homo sapiens (Human)|
          Length = 776

 Score = 33.5 bits (75), Expect = 3.7
 Identities = 31/114 (27%), Positives = 53/114 (46%), Gaps = 3/114 (2%)
 Frame = +3

Query: 360 AGMSVARFDFSWKDATYHQETLDNLRKAAQN--VKKLCPIMLDTVGPEIQVHNPTGGAIE 533
           + M VA+    ++     +E LDNL K A+N  +K   P +L T GPEI+         E
Sbjct: 626 SAMDVAKAYADYRIIDLIKEKLDNLPKPAENQKLKGKTPPILKTEGPEIKKEE------E 679

Query: 534 LIGGNH-VTITPDLSKAPSADILPIKFGDLAKVVKKGDTLFIGQYLFTGSETTS 692
           L+   + V  T +  K    +++ +     +   KK D  FI + +++   TT+
Sbjct: 680 LLSSIYGVPTTSEGKKVQKGNVVHLNSLITSGYTKKVDITFIPRRIWSPEATTA 733

---

>Q84GK0:EATA_ECOLI Serine protease eatA precursor - Escherichia coli|
          Length = 1364

 Score = 33.1 bits (74), Expect = 4.8
 Identities = 51/227 (22%), Positives = 81/227 (35%), Gaps = 41/227 (18%)
 Frame = +3

Query: 171 RSLADLPSAAEMQGGNHMLLEEPVRLASVLAPAKPKVFPSLTKIVGTLGPNSHSVEVIEE 350
           R  A+   A  +   N  + ++   L  VL  A    F S T   GTL P  H++   + 
Sbjct: 69  RDFAENKGAFIVGASNINIYDKNGVLVGVLDKAPMPDFSSATMNTGTLPPGDHTLYSPQY 128

Query: 351 CLTA----GMSVARFDFSWKDATYHQETLDN-----LRKAAQNVKKLCPIMLDTVGP--- 494
            +TA    G  +  F     + T   E   N     +R+  + V ++ P  + +VG    
Sbjct: 129 VVTAKHVNGSDIMSFGHIQNNYTVVGENNHNSLDIKIRRLNKIVTEVAPAEISSVGAVNG 188

Query: 495 ------EIQVHNPTGGAIELIGGNHVTITP----------------------DLSKAPSA 590
                   +     GG ++ I   +  +TP                       +  AP+ 
Sbjct: 189 AYQEGGRFKAFYRLGGGLQYIKDKNGNLTPVYTNGGFLTGGTISALSSYNNGQMITAPTG 248

Query: 591 DILPIKFGDLAKVVKKGDTLFIGQYLFTGSETTSLWLEV-METSGEE 728
           DI     G LA  + KGD+   G  LF        W+ V + +SG E
Sbjct: 249 DIFNPANGPLANYLNKGDS---GSPLFAYDSLDKKWVLVGVLSSGSE 292

---

>P50748:KNTC1_HUMAN Kinetochore-associated protein 1 - Homo sapiens (Human)|
          Length = 2209

 Score = 32.7 bits (73), Expect = 6.3
 Identities = 39/189 (20%), Positives = 79/189 (41%), Gaps = 7/189 (3%)
 Frame = +3

Query: 417  ETLDNLRKAAQNVKKLCPIMLDTVGPEIQVHNPTGGAIELIGGNHVTITPDLSKAPSADI 596
            E+L N   A+ +++KLCP   + V P ++   P G  I             L+K      
Sbjct: 585  ESLLNSMSASVSLQKLCPWFKNDVIPFVRRTVPEGQII-------------LAKWLEQAA 631

Query: 597  LPIKFGDLAKVVKKGDTLFIGQYLFTGSETTSL-------WLEVMETSGEEVICFVKNTA 755
              ++  D A   + G  L + +  FT  +T  L       W+ + +    E +C ++   
Sbjct: 632  RNLELTDKANWPENG--LQLAEIFFTAEKTDELGLASSWHWISLKDYQNTEEVCQLRTLV 689

Query: 756  TLSGPIFTLHVSQVHISMPTLSEYDKQVISTWGLDNSVDIISLSHTRSSEDVRELRAFLQ 935
                 + TLH  + +     LS+++K+  +T  +    D +       S   + +R +++
Sbjct: 690  NNLRELITLH--RKYNCKLALSDFEKENTTTI-VFRMFDKVLAPELIPSILEKFIRVYMR 746

Query: 936  SHNLQDTQI 962
             H+LQ+ ++
Sbjct: 747  EHDLQEEEL 755

---

>P49863:GRAK_HUMAN Granzyme K precursor - Homo sapiens (Human)|
          Length = 264

 Score = 32.7 bits (73), Expect = 6.3
 Identities = 39/123 (31%), Positives = 59/123 (47%), Gaps = 3/123 (2%)
 Frame = +3

Query: 783  HVSQVHI-SMPTLSEYDKQVISTWGLDNSVDIISLSHTRSSEDVRELRAFLQSHNLQDTQ 959
            HV  +HI S  +L    K  ++ WG   + D  SL   R S+ +RE+   + S  L ++Q
Sbjct: 131  HVKMLHIRSKTSLRSGTKCKVTGWG---ATDPDSL---RPSDTLREVTVTVLSRKLCNSQ 184

Query: 960  IYAKIENAEGLEHFDEILQ-EADGIIIS-RGDLGIDLPPERVFMSQKTGIHKCNMAGKPV 1133
             Y    N +     D +   +A G   S +GD G  L  + VF +  +G H+C +A KP 
Sbjct: 185  SYY---NGDPFITKDMVCAGDAKGQKDSCKGDSGGPLICKGVFHAIVSGGHECGVATKPG 241

Query: 1134 IIT 1142
            I T
Sbjct: 242  IYT 244

---

>P97043:TRME_LEPIN Probable tRNA modification GTPase trmE - Leptospira interrogans|
          Length = 456

 Score = 32.3 bits (72), Expect = 8.2
 Identities = 22/71 (30%), Positives = 34/71 (47%)
 Frame = +3

Query: 267 AKPKVFPSLTKIVGTLGPNSHSVEVIEECLTAGMSVARFDFSWKDATYHQETLDNLRKAA 446
           A+  VF  +T+    L   S  + +  EC       A  DFS +D TY  E+L+  +   
Sbjct: 148 AQKNVFGEVTRFTSNL--RSQLISLKAEC------EAEIDFSTEDLTY--ESLEERKTRI 197

Query: 447 QNVKKLCPIML 479
           +NVK LC  ++
Sbjct: 198 ENVKSLCQTLI 208

---

>Q72VY6:TRME_LEPIC tRNA modification GTPase trmE - Leptospira interrogans serogroup|
           Icterohaemorrhagiae serovar copenhageni
          Length = 456

 Score = 32.3 bits (72), Expect = 8.2
 Identities = 22/71 (30%), Positives = 34/71 (47%)
 Frame = +3

Query: 267 AKPKVFPSLTKIVGTLGPNSHSVEVIEECLTAGMSVARFDFSWKDATYHQETLDNLRKAA 446
           A+  VF  +T+    L   S  + +  EC       A  DFS +D TY  E+L+  +   
Sbjct: 148 AQKNVFGEVTRFTSNL--RSQLISLKAEC------EAEIDFSTEDLTY--ESLEERKTRI 197

Query: 447 QNVKKLCPIML 479
           +NVK LC  ++
Sbjct: 198 ENVKSLCQTLI 208

---

>P25009:PUC1_SCHPO Cyclin puc1 - Schizosaccharomyces pombe (Fission yeast)|
          Length = 359

 Score = 32.3 bits (72), Expect = 8.2
 Identities = 23/75 (30%), Positives = 37/75 (49%), Gaps = 8/75 (10%)
 Frame = -2

Query: 1324 YTVSASAHILPTVLTA-----STGYCPRSVSAP---SKIPSVPSRTAFATSVASARVGRR 1169
            +T ++S+ I P +L A     S G C  +VS     SK PS+ + TAF     S      
Sbjct: 13   HTPTSSSSIEPKILAACSYSLSVGPCSLAVSPKGVNSKSPSLKNETAFVVDSVSTLSAES 72

Query: 1168 LSIMLSTTLVMITGL 1124
             +++ +T   ++TGL
Sbjct: 73   SALLYNTQSSLLTGL 87

---

>Q8NUT2:LDHD_STAAW D-lactate dehydrogenase - Staphylococcus aureus (strain MW2)|
          Length = 330

 Score = 32.3 bits (72), Expect = 8.2
 Identities = 22/87 (25%), Positives = 42/87 (48%), Gaps = 14/87 (16%)
 Frame = +3

Query: 822  EYDKQVISTWGLDNSVDIISLSHTRSSEDVRELRAF-----LQSHNLQDTQIYAKIEN-- 980
            +Y+K++   WG  N+V++ +     SS  V +L+ +     +Q   L+D  +Y K+E+  
Sbjct: 11   DYEKEMALNWGKKNNVEVTTSKELLSSATVDQLKDYDGVTTMQFGKLED-DVYPKLESYG 69

Query: 981  -------AEGLEHFDEILQEADGIIIS 1040
                     G + +D  L +   I+IS
Sbjct: 70   IKQIAQRTAGFDMYDLDLAKKHNIVIS 96

---

>Q6G6F1:LDHD_STAAS D-lactate dehydrogenase - Staphylococcus aureus (strain MSSA476)|
          Length = 330

 Score = 32.3 bits (72), Expect = 8.2
 Identities = 22/87 (25%), Positives = 42/87 (48%), Gaps = 14/87 (16%)
 Frame = +3

Query: 822  EYDKQVISTWGLDNSVDIISLSHTRSSEDVRELRAF-----LQSHNLQDTQIYAKIEN-- 980
            +Y+K++   WG  N+V++ +     SS  V +L+ +     +Q   L+D  +Y K+E+  
Sbjct: 11   DYEKEMALNWGKKNNVEVTTSKELLSSATVDQLKDYDGVTTMQFGKLED-DVYPKLESYG 69

Query: 981  -------AEGLEHFDEILQEADGIIIS 1040
                     G + +D  L +   I+IS
Sbjct: 70   IKQIAQRTAGFDMYDLDLAKKHNIVIS 96


  Database: uniprot_sprot.fasta.out
    Posted date:  Jul 19, 2007  5:58 PM
  Number of letters in database: 100,686,439
  Number of sequences in database:  274,295
  
Lambda     K      H
   0.318    0.134    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 274295
Number of Hits to DB: 377,105,081
Number of extensions: 8346747
Number of successful extensions: 22829
Number of sequences better than 10.0: 109
Number of HSP's gapped: 22517
Number of HSP's successfully gapped: 112
Length of query: 718
Length of database: 100,686,439
Length adjustment: 121
Effective length of query: 597
Effective length of database: 67,496,744
Effective search space: 40295556168
Effective search space used: 40295556168
Neighboring words threshold: 12
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)

---