ナショナルバイオリソースプロジェクト
-Barley Genetic Resources Database-
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| Clone Name | FLbaf156b23 |
|---|---|
| Clone Library Name | barley_pub |
>Q05609:CTR1_ARATH Serine/threonine-protein kinase CTR1 - Arabidopsis thaliana| (Mouse-ear cress) Length = 821 Score = 348 bits (893), Expect = 8e-95 Identities = 169/272 (62%), Positives = 214/272 (78%), Gaps = 2/272 (0%) Frame = +1 Query: 2056 ECEILWEDLVIDERIGIGSYGEVYHADWNGTEVAVKKFLDQEFYGDALEEFRCEVRIMRR 2235 + +I W DL I E+IG GS+G V+ A+W+G++VAVK ++Q+F+ + + EF EV IM+R Sbjct: 543 DMDIPWCDLNIKEKIGAGSFGTVHRAEWHGSDVAVKILMEQDFHAERVNEFLREVAIMKR 602 Query: 2236 LRHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNC--QIDEKRRIKMALDVARGM 2409 LRHPNIVLFMGAVT+PP+LSIV+EYL RGSLY+++H+ Q+DE+RR+ MA DVA+GM Sbjct: 603 LRHPNIVLFMGAVTQPPNLSIVTEYLSRGSLYRLLHKSGAREQLDERRRLSMAYDVAKGM 662 Query: 2410 NCLHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAGTPEWMAPEV 2589 N LH P IVHRDLKSPNLLVD +TVKVCDFGLSRLK STFLSSKS AGTPEWMAPEV Sbjct: 663 NYLHNRNPPIVHRDLKSPNLLVDKKYTVKVCDFGLSRLKASTFLSSKSAAGTPEWMAPEV 722 Query: 2590 LRNEQSNEKCDIYSFGVILWELATLRKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVAS 2769 LR+E SNEK D+YSFGVILWELATL++PW +N QVV AVGF+ +RL+IP+ ++P VA+ Sbjct: 723 LRDEPSNEKSDVYSFGVILWELATLQQPWGNLNPAQVVAAVGFKCKRLEIPRNLNPQVAA 782 Query: 2770 IIRDCWQKDPNLRPSFIQLTSYLKTLQRLVIP 2865 II CW +P RPSF + L+ L + +P Sbjct: 783 IIEGCWTNEPWKRPSFATIMDLLRPLIKSAVP 814 Score = 110 bits (275), Expect = 4e-23 Identities = 69/210 (32%), Positives = 110/210 (52%), Gaps = 9/210 (4%) Frame = +1 Query: 379 TAESLSRRYRDYNFLDYNEKVIDGFYDIFGPSA-------ESSGHGKIPSLAELQM--SI 531 +AE++S R+ L Y +KV DGFY + G + G+IPS+ L+ S Sbjct: 207 SAETVSHRFWVNGCLSYYDKVPDGFYMMNGLDPYIWTLCIDLHESGRIPSIESLRAVDSG 266 Query: 532 GDLGYEVIVVDYKFDNALQEMKEVAECCLLGCPDITVLVRRIAEVVADHMGGPVIDANEM 711 D E I+VD + D A +E+ C +V ++A+++ + MGGPVI + Sbjct: 267 VDSSLEAIIVDRRSDPAFKELHNRVHDISCSCITTKEVVDQLAKLICNRMGGPVIMGEDE 326 Query: 712 ITRWLSKSIEQRTSHQTSLLHIGSIEIGLSRHRALLFKILADMVGIPCKLVKGSHYTGVV 891 + + I+ ++ IGS+ +GL RHRALLFK+LAD++ +PC++ KG Y Sbjct: 327 LVPMWKECIDGLKEIFKVVVPIGSLSVGLCRHRALLFKVLADIIDLPCRIAKGCKYCNRD 386 Query: 892 DDAINIIKMDNKREFLVDVMAAPGTLIPAD 981 D A +++ RE+LVD++ PG L D Sbjct: 387 DAASCLVRFGLDREYLVDLVGKPGHLWEPD 416
>Q7T6X2:YR826_MIMIV Putative serine/threonine-protein kinase/receptor R826 precursor -| Mimivirus Length = 1657 Score = 202 bits (513), Expect = 1e-50 Identities = 90/250 (36%), Positives = 162/250 (64%) Frame = +1 Query: 2065 ILWEDLVIDERIGIGSYGEVYHADWNGTEVAVKKFLDQEFYGDALEEFRCEVRIMRRLRH 2244 I ++++ + E+IG+GSYG VY W +VA+KKF+ Q+ + L R E+ +++L H Sbjct: 1394 INYDEIKMGEQIGLGSYGVVYRGKWKNVDVAIKKFIKQKIDENHLLGIREEIAFLKKLHH 1453 Query: 2245 PNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGMNCLHT 2424 PNI+ +GA + P++ IV+EY+ +G+L + +++ ++IK+ +++A+G++ LH+ Sbjct: 1454 PNIITMVGASLKKPNICIVTEYMAKGNLRDAMRTCTPKLEWHQKIKILVNIAKGISYLHS 1513 Query: 2425 SVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAGTPEWMAPEVLRNEQ 2604 P I+HRD+K N+L+D+NW VK+ DFG +R+K + ++ GTP W APE++RN+ Sbjct: 1514 FDPPIIHRDIKPSNILIDENWNVKIADFGFARIKEENAIMTR--CGTPCWTAPEIIRNDI 1571 Query: 2605 SNEKCDIYSFGVILWELATLRKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVASIIRDC 2784 +EK D++SFG+++WE+ T ++P+ G N M++ + +D R IP++ A ++R C Sbjct: 1572 YDEKVDVFSFGIVMWEVLTCKEPFIGANFMKITMDI-LEDVRPKIPQDCPEEFAKLMRKC 1630 Query: 2785 WQKDPNLRPS 2814 W RP+ Sbjct: 1631 WHAKSTKRPT 1640 Score = 190 bits (483), Expect = 3e-47 Identities = 106/271 (39%), Positives = 161/271 (59%), Gaps = 9/271 (3%) Frame = +1 Query: 2062 EILWEDLVIDERIGIGSYGEVYHADWNGTEVAVKKFL-DQEFYGDALEEFRCEVRIMRRL 2238 EI + +L + E++G G++GEV+ W GTEVAVK D+ D F+ EVR+M L Sbjct: 780 EIDFHELELGEQLGTGAFGEVHKGTWRGTEVAVKMISPDKTITKDIERNFKDEVRVMTTL 839 Query: 2239 RHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNC-QIDEKRRIKMALDVARGMNC 2415 RHPN+VLFM A T+PP + IV E++ GSL+ ++ I ++K+A ++GM+ Sbjct: 840 RHPNVVLFMAASTKPPKMCIVMEFMALGSLHDLLKNELIPDIPFALKVKIAYQASKGMHF 899 Query: 2416 LHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHST-FLSSKSTAGTPEWMAPEVL 2592 LH+S I HRDLKS NLL+D W VKV DFGL++ K ++ + AGT +W APE+L Sbjct: 900 LHSS--GITHRDLKSLNLLLDIKWNVKVSDFGLTKFKSDVKSINPEKFAGTIQWTAPEIL 957 Query: 2593 RNEQSNE--KCDIYSFGVILWELATLRKPWHGMNQMQVVGAVGFQDRRL----DIPKEVD 2754 ++ + D+YSFG+I+WEL T +P+ GM+ + +V + R + EV Sbjct: 958 SEDREVDYILSDVYSFGIIMWELITRDQPYFGMSPAAIAVSVIRDNYRPVISDQLRSEVA 1017 Query: 2755 PIVASIIRDCWQKDPNLRPSFIQLTSYLKTL 2847 P ++ CW DP +RP+F+++ + L L Sbjct: 1018 PEYIELLTSCWHFDPTIRPTFLEIMTRLSNL 1048
>Q7T6Y2:YR831_MIMIV Putative serine/threonine-protein kinase/receptor R831 precursor -| Mimivirus Length = 1624 Score = 199 bits (507), Expect = 5e-50 Identities = 102/273 (37%), Positives = 166/273 (60%), Gaps = 2/273 (0%) Frame = +1 Query: 2026 KVDLVLDEVSECE--ILWEDLVIDERIGIGSYGEVYHADWNGTEVAVKKFLDQEFYGDAL 2199 K D L + C I ++++ I ++IG+GSYG V++ W G +VAVKKF+ Q+ L Sbjct: 1344 KEDSFLTSANMCRWIINYDEISIGKQIGLGSYGIVFNGKWKGVDVAVKKFVKQKLSETQL 1403 Query: 2200 EEFRCEVRIMRRLRHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRI 2379 EFR E+ + L+H NIV F+GA + P++ IV+EY+ G+L ++ P+ +I ++ Sbjct: 1404 LEFRAEMAFLSELKHSNIVTFIGACIKKPNICIVTEYMRMGNLRDVLKNPDIKITFANKL 1463 Query: 2380 KMALDVARGMNCLHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTA 2559 K+ A G++ LH+S P IVHRD+K N+LVD+++ VK+ DFG +R+K ++ + Sbjct: 1464 KLLYGAAMGIDYLHSSNPMIVHRDIKPANILVDEHFNVKIADFGFARIKEDN--TTMTRC 1521 Query: 2560 GTPEWMAPEVLRNEQSNEKCDIYSFGVILWELATLRKPWHGMNQMQVVGAVGFQDRRLDI 2739 GTP W APEV+R E+ EK D++SFGV++WE+ T ++P+ N M+V + + R I Sbjct: 1522 GTPCWTAPEVIRGEKYCEKADVFSFGVVMWEVLTGKEPFAECNFMKVSLDI-LEGGRPII 1580 Query: 2740 PKEVDPIVASIIRDCWQKDPNLRPSFIQLTSYL 2838 P + A +I+ CW + RP+ ++ L Sbjct: 1581 PSDCPHEFAKLIKKCWHAKAHKRPTMTEVVQQL 1613 Score = 190 bits (482), Expect = 4e-47 Identities = 113/276 (40%), Positives = 157/276 (56%), Gaps = 11/276 (3%) Frame = +1 Query: 2053 SECEILWEDLVIDERIGIGSYGEVYHADWNGTEVAVKKFLDQEFYGDALEEFRCEVRIMR 2232 ++ EI + +L I E +G G YGEVY + W GTEVAVK + D F EV+IM Sbjct: 777 NDWEIDFSELEIGETLGTGGYGEVYKSIWKGTEVAVKLISSKHVSKDMERSFFEEVKIMT 836 Query: 2233 RLRHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNC-QIDEKRRIKMALDVARGM 2409 LRHPN+VLFM A T+ P++ IV E++ GSLY ++ +I +IKMA ++GM Sbjct: 837 SLRHPNVVLFMAASTKSPNMCIVMEFMSLGSLYDLLGNELIPEIPYALKIKMAYQASKGM 896 Query: 2410 NCLHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKST----AGTPEWM 2577 + LH+S IVHRDLKS NLL+D W VKV DFGL+++K L K T GT W+ Sbjct: 897 HFLHSS--GIVHRDLKSLNLLLDSKWNVKVSDFGLTKVKSE--LDKKKTNDNIIGTIHWI 952 Query: 2578 APEVLRN--EQSNEKCDIYSFGVILWELATLRKPWHGMNQMQVVGAVGFQDRRLDIPKEV 2751 APE+L + E D+YSFG+ILWEL T +P+ GM + +V R I E Sbjct: 953 APEILNDSTEVDYILADVYSFGIILWELLTREQPYKGMTPAAIAVSVIRDGMRPPISDEA 1012 Query: 2752 DPI----VASIIRDCWQKDPNLRPSFIQLTSYLKTL 2847 +I+ CW D +RP+F+++ + L + Sbjct: 1013 VTAHSIEYIDLIKQCWHSDTIIRPTFLEIMTRLSNI 1048
>Q5UQG7:YR818_MIMIV Putative serine/threonine-protein kinase/receptor R818 precursor -| Mimivirus Length = 1651 Score = 198 bits (503), Expect = 1e-49 Identities = 112/274 (40%), Positives = 168/274 (61%), Gaps = 10/274 (3%) Frame = +1 Query: 2056 ECEILWEDLVIDERIGIGSYGEVYHADWNGTEVAVKKFLDQEFYGDALEEFRCEVRIMRR 2235 E E+ + +L E +G G GEV+ A W GTEVAVKK ++ DA F+ E+ M Sbjct: 785 EWEVDFHELDFMESLGSGGSGEVFKAMWKGTEVAVKKLVNSNITKDAERNFKQEIHRMTS 844 Query: 2236 LRHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKII-HRPNCQIDEKRRIKMALDVARGMN 2412 LRHPN+VLFM A TRPP++ IV E++ GSLY ++ + +I RI++A A+GM+ Sbjct: 845 LRHPNVVLFMAASTRPPNMCIVMEFMSLGSLYDLLGNELVTEIPPVLRIRIAYQAAKGMH 904 Query: 2413 CLHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHST---FLSSKSTAGTPEWMAP 2583 LH+S IVHRDLKS NLL+D W VKV DFGL+++K + + + + + +W AP Sbjct: 905 FLHSS--DIVHRDLKSLNLLLDSKWNVKVSDFGLTKIKDNNKGKSSTKEDSVCSIQWTAP 962 Query: 2584 EVLRNEQSNE--KCDIYSFGVILWELATLRKPWHGMNQMQVVGAVGFQDRRLDIPKEVDP 2757 EVL +Q + D+YSFG+I+WEL T +P+ G++ + AV + R +I +E Sbjct: 963 EVLSEKQDIDYILADVYSFGIIMWELMTRLRPYIGLSPAAIAVAVIRDNLRPEIQEEDIN 1022 Query: 2758 IVAS----IIRDCWQKDPNLRPSFIQLTSYLKTL 2847 +++S ++ CW KD +RPSF+++ + L TL Sbjct: 1023 LMSSDYVELVNICWHKDTMIRPSFLEIMTKLSTL 1056 Score = 195 bits (496), Expect = 9e-49 Identities = 98/250 (39%), Positives = 152/250 (60%) Frame = +1 Query: 2065 ILWEDLVIDERIGIGSYGEVYHADWNGTEVAVKKFLDQEFYGDALEEFRCEVRIMRRLRH 2244 I ++D+ I ++IG+GSYG V W VAVKKF+ Q+ + EFR E+ + +LRH Sbjct: 1389 INYDDIQIGKQIGVGSYGIVNMGKWKNINVAVKKFVKQKIDEKQMLEFRAEIAFLSQLRH 1448 Query: 2245 PNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGMNCLHT 2424 P+I+L +GA + P++ IV+E++ GSL +I + + K +IKM A G+ LH Sbjct: 1449 PHIILMIGACLKRPNICIVTEFMGNGSLRNVI--KTTKPEWKLKIKMLYQTALGIGYLHN 1506 Query: 2425 SVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAGTPEWMAPEVLRNEQ 2604 S P I+HRD+K N+LVDD+ VK+ DFG +R+K S + GTP W APE++R E+ Sbjct: 1507 SDPIIIHRDIKPSNILVDDSMNVKIADFGFARIKEEN--SVMTRCGTPCWTAPEIIRGEK 1564 Query: 2605 SNEKCDIYSFGVILWELATLRKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVASIIRDC 2784 EK D++SFG+++WE+ T ++P+ G N M+V + + R IP + +++ C Sbjct: 1565 YTEKVDVFSFGIVMWEVLTCKEPFSGCNFMKVSMDI-LEGARPQIPSDCPIDFTKLMKQC 1623 Query: 2785 WQKDPNLRPS 2814 W P+ RPS Sbjct: 1624 WHAKPDKRPS 1633
>Q9ESL4:MLTK_MOUSE Mitogen-activated protein kinase kinase kinase MLT - Mus musculus| (Mouse) Length = 802 Score = 182 bits (461), Expect = 1e-44 Identities = 104/266 (39%), Positives = 149/266 (56%), Gaps = 4/266 (1%) Frame = +1 Query: 2062 EILWEDLVIDERIGIGSYGEVYHADW--NGTEVAVKKFLDQEFYGDALEEFRCEVRIMRR 2235 +I ++DL E G GS+G VY A W EVAVKK L E E I+ Sbjct: 10 QIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEK----------EAEILSV 59 Query: 2236 LRHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQ-IDEKRRIKMALDVARGMN 2412 L H NI+ F G + PP+ IV+EY GSLY I+ + +D + + A DVA+GM+ Sbjct: 60 LSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMEHIMTWATDVAKGMH 119 Query: 2413 CLHTSVPT-IVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAGTPEWMAPEV 2589 LH P ++HRDLKS N+++ + +K+CDFG SR + T + S GT WMAPEV Sbjct: 120 YLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHT--THMSLVGTFPWMAPEV 177 Query: 2590 LRNEQSNEKCDIYSFGVILWELATLRKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVAS 2769 +++ +E CD YS+GV+LWE+ T P+ G+ +QV V ++ RL IP A Sbjct: 178 IQSLPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAE 237 Query: 2770 IIRDCWQKDPNLRPSFIQLTSYLKTL 2847 ++ CW+ D RPSF Q+ S L+++ Sbjct: 238 LLHQCWEADAKKRPSFKQIISILESM 263
>Q9NYL2:MLTK_HUMAN Mitogen-activated protein kinase kinase kinase MLT - Homo sapiens| (Human) Length = 800 Score = 181 bits (459), Expect = 2e-44 Identities = 104/266 (39%), Positives = 148/266 (55%), Gaps = 4/266 (1%) Frame = +1 Query: 2062 EILWEDLVIDERIGIGSYGEVYHADW--NGTEVAVKKFLDQEFYGDALEEFRCEVRIMRR 2235 +I ++DL E G GS+G VY A W EVAVKK L E E I+ Sbjct: 10 QIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEK----------EAEILSV 59 Query: 2236 LRHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQ-IDEKRRIKMALDVARGMN 2412 L H NI+ F G + PP+ IV+EY GSLY I+ + +D + A DVA+GM+ Sbjct: 60 LSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMH 119 Query: 2413 CLHTSVPT-IVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAGTPEWMAPEV 2589 LH P ++HRDLKS N+++ + +K+CDFG SR + T + S GT WMAPEV Sbjct: 120 YLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHT--THMSLVGTFPWMAPEV 177 Query: 2590 LRNEQSNEKCDIYSFGVILWELATLRKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVAS 2769 +++ +E CD YS+GV+LWE+ T P+ G+ +QV V ++ RL IP A Sbjct: 178 IQSLPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAE 237 Query: 2770 IIRDCWQKDPNLRPSFIQLTSYLKTL 2847 ++ CW+ D RPSF Q+ S L+++ Sbjct: 238 LLHQCWEADAKKRPSFKQIISILESM 263
>Q5TCX8:M3KL4_HUMAN Mitogen-activated protein kinase kinase kinase - Homo sapiens (Human)| Length = 1036 Score = 177 bits (448), Expect = 3e-43 Identities = 115/313 (36%), Positives = 166/313 (53%), Gaps = 25/313 (7%) Frame = +1 Query: 1999 VSPSQVGSSKVDLVLDEVSECEILWEDLVIDERIGIGSYGEVYHADWNGTEVAVKKFLD- 2175 V+P + +S S + +E L + E IG G +G+VY A W G EVAVK Sbjct: 97 VAPCRPAASPAPPPSRPSSPVHVAFERLELKELIGAGGFGQVYRATWQGQEVAVKAARQD 156 Query: 2176 -QEFYGDALEEFRCEVRIMRRLRHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPN 2352 ++ A E R E R+ LRHPNI+ G + PHL +V E+ G+L + + N Sbjct: 157 PEQDAAAAAESVRREARLFAMLRHPNIIELRGVCLQQPHLCLVLEFARGGALNRALAAAN 216 Query: 2353 CQIDEK-------RRI------KMALDVARGMNCLHTS--VPTIVHRDLKSPNLLV---- 2475 D + RRI A+ +ARGM LH VP I+HRDLKS N+L+ Sbjct: 217 AAPDPRAPGPRRARRIPPHVLVNWAVQIARGMLYLHEEAFVP-ILHRDLKSSNILLLEKI 275 Query: 2476 --DD--NWTVKVCDFGLSRLKHSTFLSSKSTAGTPEWMAPEVLRNEQSNEKCDIYSFGVI 2643 DD N T+K+ DFGL+R H T + STAGT WMAPEV+++ ++ DI+S+GV+ Sbjct: 276 EHDDICNKTLKITDFGLAREWHRT--TKMSTAGTYAWMAPEVIKSSLFSKGSDIWSYGVL 333 Query: 2644 LWELATLRKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVASIIRDCWQKDPNLRPSFIQ 2823 LWEL T P+ G++ + V V L IP A ++++CWQ+DP++RPSF Sbjct: 334 LWELLTGEVPYRGIDGLAVAYGVAVNKLTLPIPSTCPEPFAKLMKECWQQDPHIRPSFAL 393 Query: 2824 LTSYLKTLQRLVI 2862 + L ++ V+ Sbjct: 394 ILEQLTAIEGAVM 406
>Q63796:M3K12_RAT Mitogen-activated protein kinase kinase kinase 12 - Rattus norvegicus| (Rat) Length = 888 Score = 175 bits (443), Expect = 1e-42 Identities = 101/277 (36%), Positives = 156/277 (56%), Gaps = 4/277 (1%) Frame = +1 Query: 2062 EILWEDLVIDERIGIGSYGEVYHADWNGTEVAVKKFLDQEFYGDALEEFRCEVRIMRRLR 2241 E+ +E+++ + +G G+ G V+ ++G EVAVKK D + +++ +R+L+ Sbjct: 152 EVPFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLK---------ETDIKHLRKLK 202 Query: 2242 HPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGMNCLH 2421 HPNI+ F G T+ P I+ E+ +G LY+++ R + + ++ +A GMN LH Sbjct: 203 HPNIITFKGVCTQAPCYCILMEFCAQGQLYEVL-RAGRPVTPSLLVDWSMGIAGGMNYLH 261 Query: 2422 TSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKST----AGTPEWMAPEV 2589 + I+HRDLKSPN+L+ + VK+ DFG S+ LS KST AGT WMAPEV Sbjct: 262 --LHKIIHRDLKSPNMLITYDDVVKISDFGTSKE-----LSDKSTKMSFAGTVAWMAPEV 314 Query: 2590 LRNEQSNEKCDIYSFGVILWELATLRKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVAS 2769 +RNE +EK DI+SFGV+LWEL T P+ ++ ++ VG L +P Sbjct: 315 IRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKI 374 Query: 2770 IIRDCWQKDPNLRPSFIQLTSYLKTLQRLVIPSHQET 2880 ++R CW + P RPSF Q+ +L V+ + QET Sbjct: 375 LLRQCWNRKPRNRPSFRQILLHLDIASADVLSTPQET 411
>Q02779:M3K10_HUMAN Mitogen-activated protein kinase kinase kinase 10 - Homo sapiens| (Human) Length = 954 Score = 175 bits (443), Expect = 1e-42 Identities = 104/275 (37%), Positives = 151/275 (54%), Gaps = 11/275 (4%) Frame = +1 Query: 2062 EILWEDLVIDERIGIGSYGEVYHADWNGTEVAVKKF-LDQEFYGDALEEFRC-EVRIMRR 2235 EI + +L ++E IG+G +G+VY A W G EVAVK LD E E C E R+ Sbjct: 92 EIPFHELQLEEIIGVGGFGKVYRALWRGEEVAVKAARLDPEKDPAVTAEQVCQEARLFGA 151 Query: 2236 LRHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGMNC 2415 L+HPNI+ GA PPHL +V EY G+L +++ ++ + A+ VARGMN Sbjct: 152 LQHPNIIALRGACLNPPHLCLVMEYARGGALSRVL--AGRRVPPHVLVNWAVQVARGMNY 209 Query: 2416 LHTSVPT-IVHRDLKSPNLLVDD--------NWTVKVCDFGLSRLKHSTFLSSKSTAGTP 2568 LH P I+HRDLKS N+L+ + + +K+ DFGL+R H T + S AGT Sbjct: 210 LHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHKT--TKMSAAGTY 267 Query: 2569 EWMAPEVLRNEQSNEKCDIYSFGVILWELATLRKPWHGMNQMQVVGAVGFQDRRLDIPKE 2748 WMAPEV+R ++ D++SFGV+LWEL T P+ ++ + V V L IP Sbjct: 268 AWMAPEVIRLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPST 327 Query: 2749 VDPIVASIIRDCWQKDPNLRPSFIQLTSYLKTLQR 2853 A ++ +CW DP+ RP F + L+ +++ Sbjct: 328 CPEPFARLLEECWDPDPHGRPDFGSILKRLEVIEQ 362
>P80192:M3K9_HUMAN Mitogen-activated protein kinase kinase kinase 9 - Homo sapiens| (Human) Length = 1104 Score = 174 bits (442), Expect = 2e-42 Identities = 101/274 (36%), Positives = 150/274 (54%), Gaps = 11/274 (4%) Frame = +1 Query: 2062 EILWEDLVIDERIGIGSYGEVYHADWNGTEVAVK--KFLDQEFYGDALEEFRCEVRIMRR 2235 EI + +L ++E IGIG +G+VY A W G EVAVK + E +E R E ++ Sbjct: 138 EIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAM 197 Query: 2236 LRHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGMNC 2415 L+HPNI+ G + P+L +V E+ G L +++ +I + A+ +ARGMN Sbjct: 198 LKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGK--RIPPDILVNWAVQIARGMNY 255 Query: 2416 LHT-SVPTIVHRDLKSPNLLVDD--------NWTVKVCDFGLSRLKHSTFLSSKSTAGTP 2568 LH ++ I+HRDLKS N+L+ N +K+ DFGL+R H T + S AGT Sbjct: 256 LHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRT--TKMSAAGTY 313 Query: 2569 EWMAPEVLRNEQSNEKCDIYSFGVILWELATLRKPWHGMNQMQVVGAVGFQDRRLDIPKE 2748 WMAPEV+R ++ D++S+GV+LWEL T P+ G++ + V V L IP Sbjct: 314 AWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPST 373 Query: 2749 VDPIVASIIRDCWQKDPNLRPSFIQLTSYLKTLQ 2850 A ++ DCW DP+ RPSF + L T++ Sbjct: 374 CPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIE 407
>Q60700:M3K12_MOUSE Mitogen-activated protein kinase kinase kinase 12 - Mus musculus| (Mouse) Length = 888 Score = 174 bits (441), Expect = 2e-42 Identities = 101/277 (36%), Positives = 155/277 (55%), Gaps = 4/277 (1%) Frame = +1 Query: 2062 EILWEDLVIDERIGIGSYGEVYHADWNGTEVAVKKFLDQEFYGDALEEFRCEVRIMRRLR 2241 E+ +E+++ + +G G+ G V+ ++G EVAVKK D + +++ +R+L+ Sbjct: 152 EVPFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLK---------ETDIKHLRKLK 202 Query: 2242 HPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGMNCLH 2421 HPNI+ F G T+ P I+ E+ +G LY+++ R + + ++ +A GMN LH Sbjct: 203 HPNIITFKGVCTQAPCYCILMEFCAQGQLYEVL-RAGRPVTPSLLVDWSMGIAGGMNYLH 261 Query: 2422 TSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKST----AGTPEWMAPEV 2589 + I+HRDLKSPN+L+ + VK+ DFG S+ LS KST AGT WMAPEV Sbjct: 262 --LHKIIHRDLKSPNMLITYDDVVKISDFGTSKE-----LSDKSTKMSFAGTVAWMAPEV 314 Query: 2590 LRNEQSNEKCDIYSFGVILWELATLRKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVAS 2769 +RNE +EK DI+SFGV+LWEL T P+ ++ ++ VG L +P Sbjct: 315 IRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKI 374 Query: 2770 IIRDCWQKDPNLRPSFIQLTSYLKTLQRLVIPSHQET 2880 ++R CW P RPSF Q+ +L V+ + QET Sbjct: 375 LLRQCWNSKPRNRPSFRQILLHLDIASADVLSTPQET 411
>Q12852:M3K12_HUMAN Mitogen-activated protein kinase kinase kinase 12 - Homo sapiens| (Human) Length = 859 Score = 174 bits (441), Expect = 2e-42 Identities = 101/277 (36%), Positives = 155/277 (55%), Gaps = 4/277 (1%) Frame = +1 Query: 2062 EILWEDLVIDERIGIGSYGEVYHADWNGTEVAVKKFLDQEFYGDALEEFRCEVRIMRRLR 2241 E+ +E+++ + +G G+ G V+ ++G EVAVKK D + +++ +R+L+ Sbjct: 119 EVPFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLK---------ETDIKHLRKLK 169 Query: 2242 HPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGMNCLH 2421 HPNI+ F G T+ P I+ E+ +G LY+++ R + + ++ +A GMN LH Sbjct: 170 HPNIITFKGVCTQAPCYCILMEFCAQGQLYEVL-RAGRPVTPSLLVDWSMGIAGGMNYLH 228 Query: 2422 TSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKST----AGTPEWMAPEV 2589 + I+HRDLKSPN+L+ + VK+ DFG S+ LS KST AGT WMAPEV Sbjct: 229 --LHKIIHRDLKSPNMLITYDDVVKISDFGTSKE-----LSDKSTKMSFAGTVAWMAPEV 281 Query: 2590 LRNEQSNEKCDIYSFGVILWELATLRKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVAS 2769 +RNE +EK DI+SFGV+LWEL T P+ ++ ++ VG L +P Sbjct: 282 IRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKI 341 Query: 2770 IIRDCWQKDPNLRPSFIQLTSYLKTLQRLVIPSHQET 2880 ++R CW P RPSF Q+ +L V+ + QET Sbjct: 342 LLRQCWNSKPRNRPSFRQILLHLDIASADVLSTPQET 378
>Q3U1V8:M3K9_MOUSE Mitogen-activated protein kinase kinase kinase 9 - Mus musculus| (Mouse) Length = 1077 Score = 173 bits (439), Expect = 4e-42 Identities = 100/274 (36%), Positives = 150/274 (54%), Gaps = 11/274 (4%) Frame = +1 Query: 2062 EILWEDLVIDERIGIGSYGEVYHADWNGTEVAVK--KFLDQEFYGDALEEFRCEVRIMRR 2235 EI + +L ++E IGIG +G+VY A W G EVAVK + E +E R E ++ Sbjct: 131 EIDFAELTLEEIIGIGGFGKVYRAFWAGDEVAVKAARHDPDEDISQTIENVRQEAKLFAM 190 Query: 2236 LRHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGMNC 2415 L+HPNI+ G + P+L +V E+ G L +++ +I + A+ +ARGMN Sbjct: 191 LKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGK--RIPPDILVNWAVQIARGMNY 248 Query: 2416 LHT-SVPTIVHRDLKSPNLLVDD--------NWTVKVCDFGLSRLKHSTFLSSKSTAGTP 2568 LH ++ I+HRDLKS N+L+ N +++ DFGL+R H T + S AGT Sbjct: 249 LHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILEITDFGLAREWHRT--TKMSAAGTY 306 Query: 2569 EWMAPEVLRNEQSNEKCDIYSFGVILWELATLRKPWHGMNQMQVVGAVGFQDRRLDIPKE 2748 WMAPEV+R ++ D++S+GV+LWEL T P+ G++ + V V L IP Sbjct: 307 AWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPST 366 Query: 2749 VDPIVASIIRDCWQKDPNLRPSFIQLTSYLKTLQ 2850 A ++ DCW DP+ RPSF + L T++ Sbjct: 367 CPEPFAKLMEDCWNPDPHSRPSFTSILDQLTTIE 400
>Q66L42:M3K10_MOUSE Mitogen-activated protein kinase kinase kinase 10 - Mus musculus| (Mouse) Length = 940 Score = 173 bits (439), Expect = 4e-42 Identities = 103/275 (37%), Positives = 152/275 (55%), Gaps = 11/275 (4%) Frame = +1 Query: 2062 EILWEDLVIDERIGIGSYGEVYHADWNGTEVAVKKF-LDQEFY-GDALEEFRCEVRIMRR 2235 EI + +L ++E IG+G +G+VY A W G EVAVK LD E E+ R E R+ Sbjct: 92 EIPFHELQLEEIIGVGGFGKVYRAVWRGEEVAVKAARLDPERDPAVTAEQVRQEARLFGA 151 Query: 2236 LRHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGMNC 2415 L+HPNI+ GA PP+L +V EY G+L +++ ++ + A+ VARGMN Sbjct: 152 LQHPNIIALRGACLSPPNLCLVMEYARGGALSRVL--AGRRVPPHVLVNWAVQVARGMNY 209 Query: 2416 LHTSVPT-IVHRDLKSPNLLVDD--------NWTVKVCDFGLSRLKHSTFLSSKSTAGTP 2568 LH P I+HRDLKS N+L+ + + +K+ DFGL+R H T + S AGT Sbjct: 210 LHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHKT--TKMSAAGTY 267 Query: 2569 EWMAPEVLRNEQSNEKCDIYSFGVILWELATLRKPWHGMNQMQVVGAVGFQDRRLDIPKE 2748 WMAPEV+R ++ D++SFGV+LWEL T P+ ++ + V V L IP Sbjct: 268 AWMAPEVIRLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPST 327 Query: 2749 VDPIVASIIRDCWQKDPNLRPSFIQLTSYLKTLQR 2853 A ++ +CW DP+ RP F + L+ +++ Sbjct: 328 CPEPFARLLEECWDPDPHGRPDFGSILKQLEVIEQ 362
>P18160:KYK1_DICDI Non-receptor tyrosine kinase spore lysis A - Dictyostelium discoideum| (Slime mold) Length = 1584 Score = 172 bits (437), Expect = 6e-42 Identities = 104/284 (36%), Positives = 156/284 (54%), Gaps = 18/284 (6%) Frame = +1 Query: 2053 SECEILWEDLVIDERIGIGSYGEVYHADWNGTEVAVKK-FLDQEFYGDALEEFRCEVRIM 2229 SE EI + +L + IG G +GEV W T+VA+K + DQ +L F+ EV I+ Sbjct: 1280 SEYEIDFNELEFGQTIGKGFFGEVKRGYWRETDVAIKIIYRDQFKTKSSLVMFQNEVGIL 1339 Query: 2230 RRLRHPNIVLFMGAVTR--PPHLSIVSEYLPRGSLYKII--HRPNCQIDEKRRIKMALDV 2397 +LRHPN+V F+GA T H IV+E++ GSL + + H + + R+K+ALD+ Sbjct: 1340 SKLRHPNVVQFLGACTAGGEDHHCIVTEWMGGGSLRQFLTDHFNLLEQNPHIRLKLALDI 1399 Query: 2398 ARGMNCLHTSVPTIVHRDLKSPNLLVDDNWT-------------VKVCDFGLSRLKHSTF 2538 A+GMN LH P I+HRDL S N+L+D N K+ DFGLSRLK Sbjct: 1400 AKGMNYLHGWTPPILHRDLSSRNILLDHNIDPKNPVVSSRQDIKCKISDFGLSRLKKEQA 1459 Query: 2539 LSSKSTAGTPEWMAPEVLRNEQSNEKCDIYSFGVILWELATLRKPWHGMNQMQVVGAVGF 2718 + G +MAPEV + + ++EK D+YS+G++L+EL T +P M M++ + Sbjct: 1460 SQMTQSVGCIPYMAPEVFKGDSNSEKSDVYSYGMVLFELLTSDEPQQDMKPMKMAHLAAY 1519 Query: 2719 QDRRLDIPKEVDPIVASIIRDCWQKDPNLRPSFIQLTSYLKTLQ 2850 + R IP I+ CW +P+ RP+F Q+ +LK ++ Sbjct: 1520 ESYRPPIPLTTSSKWKEILTQCWDSNPDSRPTFKQIIVHLKEME 1563
>Q2MHE4:HT1_ARATH Serine/threonine-protein kinase HT1 - Arabidopsis thaliana (Mouse-ear| cress) Length = 390 Score = 172 bits (435), Expect = 1e-41 Identities = 92/265 (34%), Positives = 149/265 (56%), Gaps = 5/265 (1%) Frame = +1 Query: 2080 LVIDERIGIGSYGEVYHADWNGTEVAVKKFL----DQEFYGDALEEFRCEVRIMRRLRHP 2247 L I + G++ +Y + VAVK +E ++F+ EV ++ RL HP Sbjct: 86 LFIGNKFASGAHSRIYRGIYKQRAVAVKMVRIPTHKEETRAKLEQQFKSEVALLSRLFHP 145 Query: 2248 NIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPN-CQIDEKRRIKMALDVARGMNCLHT 2424 NIV F+ A +PP I++EY+ +G+L +++ + + +++ALD++RGM LH+ Sbjct: 146 NIVQFIAACKKPPVYCIITEYMSQGNLRMYLNKKEPYSLSIETVLRLALDISRGMEYLHS 205 Query: 2425 SVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAGTPEWMAPEVLRNEQ 2604 ++HRDLKS NLL++D VKV DFG S L+ + +K GT WMAPE+++ + Sbjct: 206 Q--GVIHRDLKSNNLLLNDEMRVKVADFGTSCLE-TQCREAKGNMGTYRWMAPEMIKEKP 262 Query: 2605 SNEKCDIYSFGVILWELATLRKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVASIIRDC 2784 K D+YSFG++LWEL T P+ GM +Q AV ++ R +P P +A +I+ C Sbjct: 263 YTRKVDVYSFGIVLWELTTALLPFQGMTPVQAAFAVAEKNERPPLPASCQPALAHLIKRC 322 Query: 2785 WQKDPNLRPSFIQLTSYLKTLQRLV 2859 W ++P+ RP F + + L+ V Sbjct: 323 WSENPSKRPDFSNIVAVLEKYDECV 347
>Q1HKZ5:M3K13_MOUSE Mitogen-activated protein kinase kinase kinase 13 - Mus musculus| (Mouse) Length = 959 Score = 171 bits (433), Expect = 2e-41 Identities = 103/287 (35%), Positives = 153/287 (53%), Gaps = 4/287 (1%) Frame = +1 Query: 2032 DLVLDEVSECEILWEDLVIDERIGIGSYGEVYHADWNGTEVAVKKFLDQEFYGDALEEFR 2211 D L + E+ +E++ + +G G+ G V+ + EVA+KK +Q Sbjct: 151 DYKLQQQDTWEVPFEEISELQWLGSGAQGAVFLGKFRAEEVAIKKVREQN---------E 201 Query: 2212 CEVRIMRRLRHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMAL 2391 +++ +R+L+HPNI+ F G T+ P I+ EY G LY+++ R +I + + + Sbjct: 202 TDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVL-RAGRKITPRLLVDWST 260 Query: 2392 DVARGMNCLHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKST----A 2559 +A GMN LH + I+HRDLKSPN+LV VK+ DFG S+ LS KST A Sbjct: 261 GIASGMNYLH--LHKIIHRDLKSPNVLVTHTDAVKISDFGTSKE-----LSDKSTKMSFA 313 Query: 2560 GTPEWMAPEVLRNEQSNEKCDIYSFGVILWELATLRKPWHGMNQMQVVGAVGFQDRRLDI 2739 GT WMAPEV+RNE +EK DI+SFGV+LWEL T P+ ++ ++ VG L + Sbjct: 314 GTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPV 373 Query: 2740 PKEVDPIVASIIRDCWQKDPNLRPSFIQLTSYLKTLQRLVIPSHQET 2880 P +++ WQ P RPSF Q +L V+ + QET Sbjct: 374 PSTCPDGFKILMKQTWQSKPRNRPSFRQTLMHLDIASADVLATPQET 420
>O43283:M3K13_HUMAN Mitogen-activated protein kinase kinase kinase 13 - Homo sapiens| (Human) Length = 966 Score = 171 bits (433), Expect = 2e-41 Identities = 103/287 (35%), Positives = 153/287 (53%), Gaps = 4/287 (1%) Frame = +1 Query: 2032 DLVLDEVSECEILWEDLVIDERIGIGSYGEVYHADWNGTEVAVKKFLDQEFYGDALEEFR 2211 D L + E+ +E++ + +G G+ G V+ + EVA+KK +Q Sbjct: 152 DYKLQQQDTWEVPFEEISELQWLGSGAQGAVFLGKFRAEEVAIKKVREQN---------E 202 Query: 2212 CEVRIMRRLRHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMAL 2391 +++ +R+L+HPNI+ F G T+ P I+ EY G LY+++ R +I + + + Sbjct: 203 TDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVL-RAGRKITPRLLVDWST 261 Query: 2392 DVARGMNCLHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKST----A 2559 +A GMN LH + I+HRDLKSPN+LV VK+ DFG S+ LS KST A Sbjct: 262 GIASGMNYLH--LHKIIHRDLKSPNVLVTHTDAVKISDFGTSKE-----LSDKSTKMSFA 314 Query: 2560 GTPEWMAPEVLRNEQSNEKCDIYSFGVILWELATLRKPWHGMNQMQVVGAVGFQDRRLDI 2739 GT WMAPEV+RNE +EK DI+SFGV+LWEL T P+ ++ ++ VG L + Sbjct: 315 GTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPV 374 Query: 2740 PKEVDPIVASIIRDCWQKDPNLRPSFIQLTSYLKTLQRLVIPSHQET 2880 P +++ WQ P RPSF Q +L V+ + QET Sbjct: 375 PSTCPDGFKILMKQTWQSKPRNRPSFRQTLMHLDIASADVLATPQET 421
>Q5R8X7:M3K13_PONPY Mitogen-activated protein kinase kinase kinase 13 - Pongo pygmaeus| (Orangutan) Length = 966 Score = 170 bits (430), Expect = 4e-41 Identities = 102/287 (35%), Positives = 153/287 (53%), Gaps = 4/287 (1%) Frame = +1 Query: 2032 DLVLDEVSECEILWEDLVIDERIGIGSYGEVYHADWNGTEVAVKKFLDQEFYGDALEEFR 2211 D L + E+ +E++ + +G G+ G V+ + EVA+KK +Q Sbjct: 152 DYKLQQQDTWEVPFEEISELQWLGSGAQGAVFLGKFRAEEVAIKKVREQN---------E 202 Query: 2212 CEVRIMRRLRHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMAL 2391 +++ +R+L+HPNI+ F G T+ P I+ EY G LY+++ R +I + + + Sbjct: 203 TDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVL-RAGRKITPRLLVDWST 261 Query: 2392 DVARGMNCLHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKST----A 2559 +A GMN LH + I+HRDLKSPN+LV VK+ DFG S+ LS KST A Sbjct: 262 GIASGMNYLH--LHKIIHRDLKSPNVLVTHTDAVKISDFGTSKE-----LSDKSTKMSFA 314 Query: 2560 GTPEWMAPEVLRNEQSNEKCDIYSFGVILWELATLRKPWHGMNQMQVVGAVGFQDRRLDI 2739 GT W+APEV+RNE +EK DI+SFGV+LWEL T P+ ++ ++ VG L + Sbjct: 315 GTVAWLAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPV 374 Query: 2740 PKEVDPIVASIIRDCWQKDPNLRPSFIQLTSYLKTLQRLVIPSHQET 2880 P +++ WQ P RPSF Q +L V+ + QET Sbjct: 375 PSTCPDGFKILMKQTWQSKPRNRPSFRQTLMHLDIASADVLATPQET 421
>Q66HA1:M3K11_RAT Mitogen-activated protein kinase kinase kinase 11 - Rattus norvegicus| (Rat) Length = 850 Score = 163 bits (412), Expect = 5e-39 Identities = 99/280 (35%), Positives = 149/280 (53%), Gaps = 12/280 (4%) Frame = +1 Query: 2059 CEIL-WEDLVIDERIGIGSYGEVYHADWNGTEVAVKKFLDQ--EFYGDALEEFRCEVRIM 2229 CE+ +++L ++E IGIG +G+VY W G VAVK E E R E R+ Sbjct: 110 CEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLF 169 Query: 2230 RRLRHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGM 2409 L HPNI+ P+L +V EY G L + + ++ + A+ +ARGM Sbjct: 170 AMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRAL--AGRRVPPHVLVNWAVQIARGM 227 Query: 2410 NCLHT-SVPTIVHRDLKSPNLLV------DD--NWTVKVCDFGLSRLKHSTFLSSKSTAG 2562 + LH ++ ++HRDLKS N+L+ DD + T+K+ DFGL+R H T + S AG Sbjct: 228 HYLHCEALVPVIHRDLKSNNILLLQPIEGDDMEHKTLKITDFGLAREWHKT--TQMSAAG 285 Query: 2563 TPEWMAPEVLRNEQSNEKCDIYSFGVILWELATLRKPWHGMNQMQVVGAVGFQDRRLDIP 2742 T WMAPEV++ ++ D++SFGV+LWEL T P+ G++ + V V L IP Sbjct: 286 TYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIP 345 Query: 2743 KEVDPIVASIIRDCWQKDPNLRPSFIQLTSYLKTLQRLVI 2862 A ++ DCW +DP+ RP F + L+ L+ V+ Sbjct: 346 STCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVL 385
>Q80XI6:M3K11_MOUSE Mitogen-activated protein kinase kinase kinase 11 - Mus musculus| (Mouse) Length = 850 Score = 163 bits (412), Expect = 5e-39 Identities = 99/280 (35%), Positives = 149/280 (53%), Gaps = 12/280 (4%) Frame = +1 Query: 2059 CEIL-WEDLVIDERIGIGSYGEVYHADWNGTEVAVKKFLDQ--EFYGDALEEFRCEVRIM 2229 CE+ +++L ++E IGIG +G+VY W G VAVK E E R E R+ Sbjct: 110 CEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLF 169 Query: 2230 RRLRHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGM 2409 L HPNI+ P+L +V EY G L + + ++ + A+ +ARGM Sbjct: 170 AMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRAL--AGRRVPPHVLVNWAVQIARGM 227 Query: 2410 NCLHT-SVPTIVHRDLKSPNLLV------DD--NWTVKVCDFGLSRLKHSTFLSSKSTAG 2562 + LH ++ ++HRDLKS N+L+ DD + T+K+ DFGL+R H T + S AG Sbjct: 228 HYLHCEALVPVIHRDLKSNNILLLQPIEGDDMEHKTLKITDFGLAREWHKT--TQMSAAG 285 Query: 2563 TPEWMAPEVLRNEQSNEKCDIYSFGVILWELATLRKPWHGMNQMQVVGAVGFQDRRLDIP 2742 T WMAPEV++ ++ D++SFGV+LWEL T P+ G++ + V V L IP Sbjct: 286 TYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIP 345 Query: 2743 KEVDPIVASIIRDCWQKDPNLRPSFIQLTSYLKTLQRLVI 2862 A ++ DCW +DP+ RP F + L+ L+ V+ Sbjct: 346 STCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVL 385
>Q16584:M3K11_HUMAN Mitogen-activated protein kinase kinase kinase 11 - Homo sapiens| (Human) Length = 847 Score = 163 bits (412), Expect = 5e-39 Identities = 99/280 (35%), Positives = 149/280 (53%), Gaps = 12/280 (4%) Frame = +1 Query: 2059 CEIL-WEDLVIDERIGIGSYGEVYHADWNGTEVAVKKFLDQ--EFYGDALEEFRCEVRIM 2229 CE+ +++L ++E IGIG +G+VY W G VAVK E E R E R+ Sbjct: 109 CEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLF 168 Query: 2230 RRLRHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGM 2409 L HPNI+ P+L +V EY G L + + ++ + A+ +ARGM Sbjct: 169 AMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRAL--AGRRVPPHVLVNWAVQIARGM 226 Query: 2410 NCLHT-SVPTIVHRDLKSPNLLV------DD--NWTVKVCDFGLSRLKHSTFLSSKSTAG 2562 + LH ++ ++HRDLKS N+L+ DD + T+K+ DFGL+R H T + S AG Sbjct: 227 HYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKT--TQMSAAG 284 Query: 2563 TPEWMAPEVLRNEQSNEKCDIYSFGVILWELATLRKPWHGMNQMQVVGAVGFQDRRLDIP 2742 T WMAPEV++ ++ D++SFGV+LWEL T P+ G++ + V V L IP Sbjct: 285 TYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIP 344 Query: 2743 KEVDPIVASIIRDCWQKDPNLRPSFIQLTSYLKTLQRLVI 2862 A ++ DCW +DP+ RP F + L+ L+ V+ Sbjct: 345 STCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVL 384
>Q7T2V3:M3K10_XENLA Mitogen-activated protein kinase kinase kinase 10 - Xenopus laevis| (African clawed frog) Length = 1005 Score = 161 bits (407), Expect = 2e-38 Identities = 98/275 (35%), Positives = 145/275 (52%), Gaps = 11/275 (4%) Frame = +1 Query: 2062 EILWEDLVIDERIGIGSYGEVYHADWNGTEVAVK--KFLDQEFYGDALEEFRCEVRIMRR 2235 EI +++L +DE IG+G +G+VY W EVAVK + E E R E +I Sbjct: 112 EIEFDELNLDEIIGVGGFGKVYKGLWRDEEVAVKAVRHDPDEDINVTAENVRQEAKIFCM 171 Query: 2236 LRHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGMNC 2415 L HPNI+ G +PPHL +V EY G L++ + ++ + A+ +A+GM Sbjct: 172 LCHPNIIALTGVCLKPPHLCLVMEYARGGPLHRAL--AGKKVPAHVLVNWAVQIAKGMTY 229 Query: 2416 LHT-SVPTIVHRDLKSPNLLV------DD--NWTVKVCDFGLSRLKHSTFLSSKSTAGTP 2568 LH ++ I+HRDL S N+L+ DD N T+ + DFGL+R T + S AGT Sbjct: 230 LHNEAIVPIIHRDLGSSNILILEKAENDDLFNKTLNITDFGLAREWQKT--TKMSAAGTY 287 Query: 2569 EWMAPEVLRNEQSNEKCDIYSFGVILWELATLRKPWHGMNQMQVVGAVGFQDRRLDIPKE 2748 WMAPEV+R ++ D++SFGV+LWEL T P+ ++ + V V L IP Sbjct: 288 AWMAPEVIRLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPST 347 Query: 2749 VDPIVASIIRDCWQKDPNLRPSFIQLTSYLKTLQR 2853 I+ CW DP+ RP+F + L T+++ Sbjct: 348 CPEPFVRILEACWDPDPHSRPTFSCILEQLTTIEQ 382
>P18161:KYK2_DICDI Tyrosine-protein kinase 2 - Dictyostelium discoideum (Slime mold)| Length = 410 Score = 159 bits (402), Expect = 7e-38 Identities = 94/268 (35%), Positives = 148/268 (55%), Gaps = 11/268 (4%) Frame = +1 Query: 2077 DLVIDERIGIGSYGEVYHADWNGTEVAVKKFL---DQEFYGDALEEFRCEVRIMRRLRHP 2247 D+ +++G G++ EV+ W G VA+KK D+E + E F EV+ +++ H Sbjct: 107 DIQFIQKVGEGAFSEVWEGWWKGIHVAIKKLKIIGDEEQFK---ERFIREVQNLKKGNHQ 163 Query: 2248 NIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRR-----IKMALDVARGMN 2412 NIV+F+GA +P I++EY+ GSLY I+H PN + + +KMA D+A G+ Sbjct: 164 NIVMFIGACYKPA--CIITEYMAGGSLYNILHNPNSSTPKVKYSFPLVLKMATDMALGLL 221 Query: 2413 CLHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAG--TPEWMAPE 2586 LH+ TIVHRDL S N+L+D+ +K+ DFGLS K + + G P W PE Sbjct: 222 HLHSI--TIVHRDLTSQNILLDELGNIKISDFGLSAEKSREGSMTMTNGGICNPRWRPPE 279 Query: 2587 VLRN-EQSNEKCDIYSFGVILWELATLRKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIV 2763 + +N +EK D+Y F +++WE+ T P+ ++ Q V + R IP+ DP + Sbjct: 280 LTKNLGHYSEKVDVYCFSLVVWEILTGEIPFSDLDGSQRSAQVAYAGLRPPIPEYCDPEL 339 Query: 2764 ASIIRDCWQKDPNLRPSFIQLTSYLKTL 2847 ++ CW+ DPN RP F + + LK + Sbjct: 340 KLLLTQCWEADPNDRPPFTYIVNKLKEI 367
>P11345:RAF1_RAT RAF proto-oncogene serine/threonine-protein kinase - Rattus| norvegicus (Rat) Length = 648 Score = 150 bits (380), Expect = 3e-35 Identities = 109/313 (34%), Positives = 169/313 (53%), Gaps = 17/313 (5%) Frame = +1 Query: 2062 EILWEDLVIDERIGIGSYGEVYHADWNGTEVAVKKFLDQEFYGDALEEFRCEVRIMRRLR 2241 EI ++++ RIG GS+G VY W+G +VAVK + + L+ FR EV ++R+ R Sbjct: 343 EIEASEVMLSTRIGSGSFGTVYKGKWHG-DVAVKILKVVDPTPEQLQAFRNEVAVLRKTR 401 Query: 2242 HPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGMNCLH 2421 H NI+LFMG +T+ +L+IV+++ SLYK +H + + I +A A+GM+ LH Sbjct: 402 HVNILLFMGYMTKD-NLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLH 460 Query: 2422 TSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKH--STFLSSKSTAGTPEWMAPEVLR 2595 I+HRD+KS N+ + + TVK+ DFGL+ +K S + G+ WMAPEV+R Sbjct: 461 AK--NIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIR 518 Query: 2596 NEQSNE---KCDIYSFGVILWELATLRKPW-HGMNQMQVVGAVGFQDRRLDIP---KEVD 2754 + +N + D+YS+G++L+EL T P+ H N+ Q++ VG D+ K Sbjct: 519 MQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSRLYKNCP 578 Query: 2755 PIVASIIRDCWQKDPNLRPSFIQLTSYLKTLQRLVIPSHQETASNHVPYEISLYR*TAH- 2931 + ++ DC +K RP F Q+ S ++ LQ H N E SL+R AH Sbjct: 579 KAMKRLVADCVKKVKEERPLFPQILSSIELLQ------HSLPKINRSASEPSLHR-AAHT 631 Query: 2932 -------LTSLPR 2949 LT+ PR Sbjct: 632 EDINACTLTTSPR 644
>Q62073:M3K7_MOUSE Mitogen-activated protein kinase kinase kinase 7 - Mus musculus| (Mouse) Length = 579 Score = 150 bits (379), Expect = 3e-35 Identities = 95/290 (32%), Positives = 153/290 (52%), Gaps = 6/290 (2%) Frame = +1 Query: 2002 SPSQVGSSKVDLVLDEVSECEILWEDLVIDERIGIGSYGEVYHADWNGTEVAVKKFLDQE 2181 S S S ++ ++ EI ++++ ++E +G G++G V A W +VA+K+ + Sbjct: 10 SSSSSASEMIEAPSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESES 69 Query: 2182 FYGDALEEFRCEVRIMRRLRHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIH--RPNC 2355 + F E+R + R+ HPNIV GA P + +V EY GSLY ++H P Sbjct: 70 ----ERKAFIVELRQLSRVNHPNIVKLYGACLNP--VCLVMEYAEGGSLYNVLHGAEPLP 123 Query: 2356 QIDEKRRIKMALDVARGMNCLHTSVP-TIVHRDLKSPNLLVDDNWTV-KVCDFGLSRLKH 2529 + L ++G+ LH+ P ++HRDLK PNLL+ TV K+CDFG + Sbjct: 124 YYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQ 183 Query: 2530 STFLSSKSTAGTPEWMAPEVLRNEQSNEKCDIYSFGVILWELATLRKPWH--GMNQMQVV 2703 + ++K +A WMAPEV +EKCD++S+G+ILWE+ T RKP+ G +++ Sbjct: 184 THMTNNKGSAA---WMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIM 240 Query: 2704 GAVGFQDRRLDIPKEVDPIVASIIRDCWQKDPNLRPSFIQLTSYLKTLQR 2853 AV R + K + + S++ CW KDP+ RPS ++ + L R Sbjct: 241 WAV-HNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMR 289
>O43318:M3K7_HUMAN Mitogen-activated protein kinase kinase kinase 7 - Homo sapiens| (Human) Length = 606 Score = 150 bits (378), Expect = 4e-35 Identities = 92/270 (34%), Positives = 146/270 (54%), Gaps = 6/270 (2%) Frame = +1 Query: 2062 EILWEDLVIDERIGIGSYGEVYHADWNGTEVAVKKFLDQEFYGDALEEFRCEVRIMRRLR 2241 EI ++++ ++E +G G++G V A W +VA+K+ + + F E+R + R+ Sbjct: 30 EIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESES----ERKAFIVELRQLSRVN 85 Query: 2242 HPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIH--RPNCQIDEKRRIKMALDVARGMNC 2415 HPNIV GA P + +V EY GSLY ++H P + L ++G+ Sbjct: 86 HPNIVKLYGACLNP--VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAY 143 Query: 2416 LHTSVP-TIVHRDLKSPNLLVDDNWTV-KVCDFGLSRLKHSTFLSSKSTAGTPEWMAPEV 2589 LH+ P ++HRDLK PNLL+ TV K+CDFG + + ++K +A WMAPEV Sbjct: 144 LHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNKGSAA---WMAPEV 200 Query: 2590 LRNEQSNEKCDIYSFGVILWELATLRKPWH--GMNQMQVVGAVGFQDRRLDIPKEVDPIV 2763 +EKCD++S+G+ILWE+ T RKP+ G +++ AV R + K + + Sbjct: 201 FEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAV-HNGTRPPLIKNLPKPI 259 Query: 2764 ASIIRDCWQKDPNLRPSFIQLTSYLKTLQR 2853 S++ CW KDP+ RPS ++ + L R Sbjct: 260 ESLMTRCWSKDPSQRPSMEEIVKIMTHLMR 289
>P00522:ABL_DROME Tyrosine-protein kinase Abl - Drosophila melanogaster (Fruit fly)| Length = 1620 Score = 150 bits (378), Expect = 4e-35 Identities = 98/285 (34%), Positives = 149/285 (52%), Gaps = 5/285 (1%) Frame = +1 Query: 1978 PRQNIECVSPSQVGSSKVDLVLDEVSECEILWEDLVIDERIGIGSYGEVYHADWN--GTE 2151 P+QN V P + E E EI D+++ ++G G YGEVY A W G Sbjct: 347 PKQNKPTVFP----------LSPEPDEWEICRTDIMMKHKLGGGQYGEVYEAVWKRYGNT 396 Query: 2152 VAVKKFLDQEFYGDALEEFRCEVRIMRRLRHPNIVLFMGAVTRPPHLSIVSEYLPRGSLY 2331 VAVK + AL++F E IM+ ++HPN+V +G TR P I++E++ G+L Sbjct: 397 VAVKTLKEDTM---ALKDFLEEAAIMKEMKHPNLVQLIGVCTREPPFYIITEFMSHGNLL 453 Query: 2332 KIIHRPNCQ-IDEKRRIKMALDVARGMNCLHTSVPTIVHRDLKSPNLLVDDNWTVKVCDF 2508 + + +D + MA +A GM+ L + +HRDL + N LV DN VKV DF Sbjct: 454 DFLRSAGRETLDAVALLYMATQIASGMSYLESR--NYIHRDLAARNCLVGDNKLVKVADF 511 Query: 2509 GLSRLKHSTFLSSKSTAGTP-EWMAPEVLRNEQSNEKCDIYSFGVILWELATL-RKPWHG 2682 GL+RL ++ + A P +W APE L + + K D+++FGV+LWE+AT P+ Sbjct: 512 GLARLMRDDTYTAHAGAKFPIKWTAPEGLAYNKFSTKSDVWAFGVLLWEIATYGMSPYPA 571 Query: 2683 MNQMQVVGAVGFQDRRLDIPKEVDPIVASIIRDCWQKDPNLRPSF 2817 ++ V + + R++ P P V ++R CWQ D RP+F Sbjct: 572 IDLTDVYHKLD-KGYRMERPPGCPPEVYDLMRQCWQWDATDRPTF 615
>P05625:RAF1_CHICK RAF proto-oncogene serine/threonine-protein kinase - Gallus gallus| (Chicken) Length = 647 Score = 149 bits (377), Expect = 6e-35 Identities = 103/295 (34%), Positives = 161/295 (54%), Gaps = 9/295 (3%) Frame = +1 Query: 2062 EILWEDLVIDERIGIGSYGEVYHADWNGTEVAVKKFLDQEFYGDALEEFRCEVRIMRRLR 2241 EI ++++ RIG GS+G VY W+G +VAVK + + + FR EV ++R+ R Sbjct: 343 EIEASEVMLSTRIGSGSFGTVYKGKWHG-DVAVKILKVVDPTPEQFQAFRNEVAVLRKTR 401 Query: 2242 HPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGMNCLH 2421 H NI+LFMG +T+ +L+IV+++ SLYK +H + + I +A A+GM+ LH Sbjct: 402 HVNILLFMGYMTKD-NLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLH 460 Query: 2422 TSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKH--STFLSSKSTAGTPEWMAPEVLR 2595 I+HRD+KS N+ + + TVK+ DFGL+ +K S + G+ WMAPEV+R Sbjct: 461 AK--NIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSILWMAPEVIR 518 Query: 2596 NEQSNE---KCDIYSFGVILWELATLRKPW-HGMNQMQVVGAVGFQDRRLDIP---KEVD 2754 + SN + D+YS+G++L+EL T P+ H N+ Q++ VG D+ K Sbjct: 519 MQDSNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCP 578 Query: 2755 PIVASIIRDCWQKDPNLRPSFIQLTSYLKTLQRLVIPSHQETASNHVPYEISLYR 2919 + ++ DC +K RP F Q+ S ++ LQ H N E SL+R Sbjct: 579 KAMKRLVADCLKKVREERPLFPQILSSIELLQ------HSLPKINRSASEPSLHR 627
>Q5R5M7:RAF1_PONPY RAF proto-oncogene serine/threonine-protein kinase - Pongo pygmaeus| (Orangutan) Length = 648 Score = 149 bits (376), Expect = 7e-35 Identities = 108/313 (34%), Positives = 168/313 (53%), Gaps = 17/313 (5%) Frame = +1 Query: 2062 EILWEDLVIDERIGIGSYGEVYHADWNGTEVAVKKFLDQEFYGDALEEFRCEVRIMRRLR 2241 EI ++++ RIG GS+G VY W+G +VAVK + + + FR EV ++R+ R Sbjct: 343 EIEASEVMLSTRIGSGSFGTVYKGKWHG-DVAVKILKVVDPTPEQFQAFRNEVAVLRKTR 401 Query: 2242 HPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGMNCLH 2421 H NI+LFMG +T+ +L+IV+++ SLYK +H + + I +A A+GM+ LH Sbjct: 402 HVNILLFMGYMTKD-NLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLH 460 Query: 2422 TSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKH--STFLSSKSTAGTPEWMAPEVLR 2595 I+HRD+KS N+ + + TVK+ DFGL+ +K S + G+ WMAPEV+R Sbjct: 461 AK--NIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIR 518 Query: 2596 NEQSNE---KCDIYSFGVILWELATLRKPW-HGMNQMQVVGAVGFQDRRLDIP---KEVD 2754 + +N + D+YS+G++L+EL T P+ H N+ Q++ VG D+ K Sbjct: 519 MQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCP 578 Query: 2755 PIVASIIRDCWQKDPNLRPSFIQLTSYLKTLQRLVIPSHQETASNHVPYEISLYR*TAH- 2931 + ++ DC +K RP F Q+ S ++ LQ H N E SL+R AH Sbjct: 579 KAMKRLVADCVKKVKEERPLFPQILSSIELLQ------HSLPKINRSASEPSLHR-AAHT 631 Query: 2932 -------LTSLPR 2949 LT+ PR Sbjct: 632 EDINACTLTTSPR 644
>P04049:RAF1_HUMAN RAF proto-oncogene serine/threonine-protein kinase - Homo sapiens| (Human) Length = 648 Score = 149 bits (376), Expect = 7e-35 Identities = 108/313 (34%), Positives = 168/313 (53%), Gaps = 17/313 (5%) Frame = +1 Query: 2062 EILWEDLVIDERIGIGSYGEVYHADWNGTEVAVKKFLDQEFYGDALEEFRCEVRIMRRLR 2241 EI ++++ RIG GS+G VY W+G +VAVK + + + FR EV ++R+ R Sbjct: 343 EIEASEVMLSTRIGSGSFGTVYKGKWHG-DVAVKILKVVDPTPEQFQAFRNEVAVLRKTR 401 Query: 2242 HPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGMNCLH 2421 H NI+LFMG +T+ +L+IV+++ SLYK +H + + I +A A+GM+ LH Sbjct: 402 HVNILLFMGYMTKD-NLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLH 460 Query: 2422 TSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKH--STFLSSKSTAGTPEWMAPEVLR 2595 I+HRD+KS N+ + + TVK+ DFGL+ +K S + G+ WMAPEV+R Sbjct: 461 AK--NIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIR 518 Query: 2596 NEQSNE---KCDIYSFGVILWELATLRKPW-HGMNQMQVVGAVGFQDRRLDIP---KEVD 2754 + +N + D+YS+G++L+EL T P+ H N+ Q++ VG D+ K Sbjct: 519 MQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCP 578 Query: 2755 PIVASIIRDCWQKDPNLRPSFIQLTSYLKTLQRLVIPSHQETASNHVPYEISLYR*TAH- 2931 + ++ DC +K RP F Q+ S ++ LQ H N E SL+R AH Sbjct: 579 KAMKRLVADCVKKVKEERPLFPQILSSIELLQ------HSLPKINRSASEPSLHR-AAHT 631 Query: 2932 -------LTSLPR 2949 LT+ PR Sbjct: 632 EDINACTLTTSPR 644
>Q99N57:RAF1_MOUSE RAF proto-oncogene serine/threonine-protein kinase - Mus musculus| (Mouse) Length = 648 Score = 148 bits (374), Expect = 1e-34 Identities = 108/313 (34%), Positives = 167/313 (53%), Gaps = 17/313 (5%) Frame = +1 Query: 2062 EILWEDLVIDERIGIGSYGEVYHADWNGTEVAVKKFLDQEFYGDALEEFRCEVRIMRRLR 2241 EI ++++ RIG GS+G VY W+G +VAVK + + L+ FR EV ++R+ R Sbjct: 343 EIEASEVMLSTRIGSGSFGTVYKGKWHG-DVAVKILKVVDPTPEQLQAFRNEVAVLRKTR 401 Query: 2242 HPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGMNCLH 2421 H NI+LFMG +T+ +L+IV+++ SLYK +H + + I +A A+GM+ LH Sbjct: 402 HVNILLFMGYMTKD-NLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLH 460 Query: 2422 TSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKH--STFLSSKSTAGTPEWMAPEVLR 2595 I+HRD+KS N+ + + TVK+ DFGL+ +K S + G+ WMAPEV+R Sbjct: 461 AK--NIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIR 518 Query: 2596 NEQSNE---KCDIYSFGVILWELATLRKPW-HGMNQMQVVGAVGFQDRRLDIP---KEVD 2754 + N + D+YS+G++L+EL P+ H N+ Q++ VG D+ K Sbjct: 519 MQDDNPFSFQSDVYSYGIVLYELMAGELPYAHINNRDQIIFMVGRGYASPDLSRLYKNCP 578 Query: 2755 PIVASIIRDCWQKDPNLRPSFIQLTSYLKTLQRLVIPSHQETASNHVPYEISLYR*TAH- 2931 + ++ DC +K RP F Q+ S ++ LQ H N E SL+R AH Sbjct: 579 KAMKRLVADCVKKVKEERPLFPQILSSIELLQ------HSLPKINRSASEPSLHR-AAHT 631 Query: 2932 -------LTSLPR 2949 LT+ PR Sbjct: 632 EDINACTLTTSPR 644
>P00532:RAF_MSV36 Serine/threonine-protein kinase-transforming protein raf - Murine| sarcoma virus 3611 Length = 323 Score = 147 bits (372), Expect = 2e-34 Identities = 106/308 (34%), Positives = 165/308 (53%), Gaps = 17/308 (5%) Frame = +1 Query: 2077 DLVIDERIGIGSYGEVYHADWNGTEVAVKKFLDQEFYGDALEEFRCEVRIMRRLRHPNIV 2256 ++++ RIG GS+G VY W+G +VAVK + + L+ FR EV ++R+ RH NI+ Sbjct: 23 EVMLSTRIGSGSFGTVYKGKWHG-DVAVKILKVVDPTPEQLQAFRNEVAVLRKTRHVNIL 81 Query: 2257 LFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGMNCLHTSVPT 2436 LFMG +T+ +L+IV+++ SLYK +H + + I +A A+GM+ LH Sbjct: 82 LFMGYMTKD-NLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAK--N 138 Query: 2437 IVHRDLKSPNLLVDDNWTVKVCDFGLSRLKH--STFLSSKSTAGTPEWMAPEVLRNEQSN 2610 I+HRD+KS N+ + + TVK+ DFGL+ +K S + G+ WMAPEV+R + N Sbjct: 139 IIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDDN 198 Query: 2611 E---KCDIYSFGVILWELATLRKPW-HGMNQMQVVGAVGFQDRRLDIP---KEVDPIVAS 2769 + D+YS+G++L+EL P+ H N+ Q++ VG D+ K + Sbjct: 199 PFSFQSDVYSYGIVLYELMAGELPYAHINNRDQIIFMVGRGYASPDLSRLYKNCPKAIKR 258 Query: 2770 IIRDCWQKDPNLRPSFIQLTSYLKTLQRLVIPSHQETASNHVPYEISLYR*TAH------ 2931 ++ DC +K RP F Q+ S ++ LQ H N E SL+R AH Sbjct: 259 LVADCVKKVKEERPLFPQILSSIELLQ------HSLPKINRSAPEPSLHR-AAHTEDINA 311 Query: 2932 --LTSLPR 2949 LT+ PR Sbjct: 312 CTLTTSPR 319
>P00531:MIL_AVIMH Serine/threonine-protein kinase-transforming protein mil - Avian| retrovirus MH2 Length = 380 Score = 147 bits (372), Expect = 2e-34 Identities = 103/295 (34%), Positives = 159/295 (53%), Gaps = 9/295 (3%) Frame = +1 Query: 2062 EILWEDLVIDERIGIGSYGEVYHADWNGTEVAVKKFLDQEFYGDALEEFRCEVRIMRRLR 2241 EI ++++ RIG GS+G VY W+G +VAVK + + + FR EV ++R+ R Sbjct: 76 EIEASEVLLSTRIGSGSFGTVYKGKWHG-DVAVKILKVVDPTPEQFQAFRNEVAVLRKTR 134 Query: 2242 HPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGMNCLH 2421 H NI+LFMG +T+ +L+IV+++ SLYK +H + + I +A A+GM+ LH Sbjct: 135 HVNILLFMGYMTKD-NLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLH 193 Query: 2422 TSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKH--STFLSSKSTAGTPEWMAPEVLR 2595 I+HRD+KS N+ + TVK+ DFGL+ +K S + G+ WMAPEV+R Sbjct: 194 AK--NIIHRDMKSNNIFLHGGLTVKIGDFGLATVKSRWSGSQQVEQPTGSILWMAPEVIR 251 Query: 2596 NEQSNE---KCDIYSFGVILWELATLRKPW-HGMNQMQVVGAVGFQDRRLDIP---KEVD 2754 + SN + D+YS+G++L+EL T P+ H N+ Q++ VG D+ K Sbjct: 252 MQDSNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCP 311 Query: 2755 PIVASIIRDCWQKDPNLRPSFIQLTSYLKTLQRLVIPSHQETASNHVPYEISLYR 2919 + ++ DC +K RP F Q+ S + LQ H N E SL+R Sbjct: 312 KAMKRLVADCLKKVREERPLFPQILSSIALLQ------HSLPKINRSASEPSLHR 360
>P10533:RMIL_AVII1 Serine/threonine-protein kinase-transforming protein Rmil - Avian| retrovirus IC10 Length = 367 Score = 146 bits (369), Expect = 5e-34 Identities = 98/293 (33%), Positives = 162/293 (55%), Gaps = 13/293 (4%) Frame = +1 Query: 2044 DEVSECEILWEDLVIDERIGIGSYGEVYHADWNGTEVAVKKFLDQEFYGDALEEFRCEVR 2223 D + EI + + +RIG GS+G VY W+G +VAVK L+ F+ EV Sbjct: 55 DSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHG-DVAVKMLNVTAPTPQQLQAFKNEVG 113 Query: 2224 IMRRLRHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVAR 2403 ++R+ RH NI+LFMG T+P L+IV+++ SLY +H + + + I +A A+ Sbjct: 114 VLRKTRHVNILLFMGYSTKP-QLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQ 172 Query: 2404 GMNCLHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKH--STFLSSKSTAGTPEWM 2577 GM+ LH +I+HRDLKS N+ + ++ TVK+ DFGL+ +K S + +G+ WM Sbjct: 173 GMDYLHAK--SIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWM 230 Query: 2578 APEVLRNEQSNE---KCDIYSFGVILWELATLRKPWHGMNQM-QVVGAVG-------FQD 2724 APEV+R + N + D+Y+FG++L+EL T + P+ +N Q++ VG Sbjct: 231 APEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSK 290 Query: 2725 RRLDIPKEVDPIVASIIRDCWQKDPNLRPSFIQLTSYLKTLQRLVIPSHQETA 2883 R + PK + ++A +C +K + RP F Q+ + ++ L R + H+ + Sbjct: 291 VRSNCPKAMKRLMA----ECLKKKRDERPLFPQILASIELLARSLPKIHRSAS 339
>P27966:RMIL_AVEVR Serine/threonine-protein kinase-transforming protein Rmil - Avian| rous-associated virus type 1 Length = 450 Score = 146 bits (369), Expect = 5e-34 Identities = 98/293 (33%), Positives = 162/293 (55%), Gaps = 13/293 (4%) Frame = +1 Query: 2044 DEVSECEILWEDLVIDERIGIGSYGEVYHADWNGTEVAVKKFLDQEFYGDALEEFRCEVR 2223 D + EI + + +RIG GS+G VY W+G +VAVK L+ F+ EV Sbjct: 71 DSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHG-DVAVKMLNVTAPTPQQLQAFKNEVG 129 Query: 2224 IMRRLRHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVAR 2403 ++R+ RH NI+LFMG T+P L+IV+++ SLY +H + + + I +A A+ Sbjct: 130 VLRKTRHVNILLFMGYSTKP-QLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQ 188 Query: 2404 GMNCLHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKH--STFLSSKSTAGTPEWM 2577 GM+ LH +I+HRDLKS N+ + ++ TVK+ DFGL+ +K S + +G+ WM Sbjct: 189 GMDYLHAK--SIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWM 246 Query: 2578 APEVLRNEQSNE---KCDIYSFGVILWELATLRKPWHGMNQM-QVVGAVG-------FQD 2724 APEV+R + N + D+Y+FG++L+EL T + P+ +N Q++ VG Sbjct: 247 APEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSK 306 Query: 2725 RRLDIPKEVDPIVASIIRDCWQKDPNLRPSFIQLTSYLKTLQRLVIPSHQETA 2883 R + PK + ++A +C +K + RP F Q+ + ++ L R + H+ + Sbjct: 307 VRSNCPKAMKRLMA----ECLKKKRDERPLFPQILASIELLARSLPKIHRSAS 355
>P11346:KRAF1_DROME Raf homolog serine/threonine-protein kinase dRAF-1 - Drosophila| melanogaster (Fruit fly) Length = 739 Score = 146 bits (369), Expect = 5e-34 Identities = 102/302 (33%), Positives = 163/302 (53%), Gaps = 15/302 (4%) Frame = +1 Query: 2023 SKVDLVLDEVSECEILW----EDLVIDERIGIGSYGEVYHADWNGTEVAVKKFLDQEFYG 2190 S +L+L + E W E+++I RIG GS+G VY A W+G VAVK + Sbjct: 406 SNKNLLLRDAKSSEENWNILAEEILIGPRIGSGSFGTVYRAHWHGP-VAVKTLNVKTPSP 464 Query: 2191 DALEEFRCEVRIMRRLRHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEK 2370 L+ F+ EV ++++ RH NI+LFMG V++P L+IV+++ SLYK +H + Sbjct: 465 AQLQAFKNEVAMLKKTRHCNILLFMGCVSKPS-LAIVTQWCEGSSLYKHVHVSETKFKLN 523 Query: 2371 RRIKMALDVARGMNCLHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSK 2550 I + VA+GM+ LH I+HRDLKS N+ + ++ +VK+ DFGL+ K T S + Sbjct: 524 TLIDIGRQVAQGMDYLHAK--NIIHRDLKSNNIFLHEDLSVKIGDFGLATAK--TRWSGE 579 Query: 2551 STAGTPE----WMAPEVLRNEQSNE---KCDIYSFGVILWELATLRKPW-HGMNQMQVVG 2706 A P WMAPEV+R ++ N + D+Y+FG++++EL P+ H N+ Q++ Sbjct: 580 KQANQPTGSILWMAPEVIRMQELNPYSFQSDVYAFGIVMYELLAECLPYGHISNKDQILF 639 Query: 2707 AVGFQDRRLD---IPKEVDPIVASIIRDCWQKDPNLRPSFIQLTSYLKTLQRLVIPSHQE 2877 VG R D + + + + DC + P RP F L + L+ + R + H+ Sbjct: 640 MVGRGLLRPDMSQVRSDAPQALKRLAEDCIKYTPKDRPLFRPLLNMLENMLRTLPKIHRS 699 Query: 2878 TA 2883 + Sbjct: 700 AS 701
>P28028:BRAF1_MOUSE B-Raf proto-oncogene serine/threonine-protein kinase - Mus musculus| (Mouse) Length = 804 Score = 146 bits (369), Expect = 5e-34 Identities = 98/293 (33%), Positives = 162/293 (55%), Gaps = 13/293 (4%) Frame = +1 Query: 2044 DEVSECEILWEDLVIDERIGIGSYGEVYHADWNGTEVAVKKFLDQEFYGDALEEFRCEVR 2223 D + EI + + +RIG GS+G VY W+G +VAVK L+ F+ EV Sbjct: 482 DSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHG-DVAVKMLNVTAPTPQQLQAFKNEVG 540 Query: 2224 IMRRLRHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVAR 2403 ++R+ RH NI+LFMG T+P L+IV+++ SLY +H + + + I +A A+ Sbjct: 541 VLRKTRHVNILLFMGYSTKP-QLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQ 599 Query: 2404 GMNCLHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKH--STFLSSKSTAGTPEWM 2577 GM+ LH +I+HRDLKS N+ + ++ TVK+ DFGL+ +K S + +G+ WM Sbjct: 600 GMDYLHAK--SIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWM 657 Query: 2578 APEVLRNEQSNE---KCDIYSFGVILWELATLRKPWHGMNQM-QVVGAVG-------FQD 2724 APEV+R + N + D+Y+FG++L+EL T + P+ +N Q++ VG Sbjct: 658 APEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSK 717 Query: 2725 RRLDIPKEVDPIVASIIRDCWQKDPNLRPSFIQLTSYLKTLQRLVIPSHQETA 2883 R + PK + ++A +C +K + RP F Q+ + ++ L R + H+ + Sbjct: 718 VRSNCPKAMKRLMA----ECLKKKRDERPLFPQILASIELLARSLPKIHRSAS 766
>P15056:BRAF1_HUMAN B-Raf proto-oncogene serine/threonine-protein kinase - Homo sapiens| (Human) Length = 766 Score = 146 bits (369), Expect = 5e-34 Identities = 98/293 (33%), Positives = 162/293 (55%), Gaps = 13/293 (4%) Frame = +1 Query: 2044 DEVSECEILWEDLVIDERIGIGSYGEVYHADWNGTEVAVKKFLDQEFYGDALEEFRCEVR 2223 D + EI + + +RIG GS+G VY W+G +VAVK L+ F+ EV Sbjct: 445 DSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHG-DVAVKMLNVTAPTPQQLQAFKNEVG 503 Query: 2224 IMRRLRHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVAR 2403 ++R+ RH NI+LFMG T+P L+IV+++ SLY +H + + + I +A A+ Sbjct: 504 VLRKTRHVNILLFMGYSTKP-QLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQ 562 Query: 2404 GMNCLHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKH--STFLSSKSTAGTPEWM 2577 GM+ LH +I+HRDLKS N+ + ++ TVK+ DFGL+ +K S + +G+ WM Sbjct: 563 GMDYLHAK--SIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWM 620 Query: 2578 APEVLRNEQSNE---KCDIYSFGVILWELATLRKPWHGMNQM-QVVGAVG-------FQD 2724 APEV+R + N + D+Y+FG++L+EL T + P+ +N Q++ VG Sbjct: 621 APEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSK 680 Query: 2725 RRLDIPKEVDPIVASIIRDCWQKDPNLRPSFIQLTSYLKTLQRLVIPSHQETA 2883 R + PK + ++A +C +K + RP F Q+ + ++ L R + H+ + Sbjct: 681 VRSNCPKAMKRLMA----ECLKKKRDERPLFPQILASIELLARSLPKIHRSAS 729
>P34908:BRAF1_COTJA B-Raf proto-oncogene serine/threonine-protein kinase - Coturnix| coturnix japonica (Japanese quail) Length = 807 Score = 146 bits (369), Expect = 5e-34 Identities = 98/293 (33%), Positives = 162/293 (55%), Gaps = 13/293 (4%) Frame = +1 Query: 2044 DEVSECEILWEDLVIDERIGIGSYGEVYHADWNGTEVAVKKFLDQEFYGDALEEFRCEVR 2223 D + EI + + +RIG GS+G VY W+G +VAVK L+ F+ EV Sbjct: 485 DSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHG-DVAVKMLNVTAPTPQQLQAFKNEVG 543 Query: 2224 IMRRLRHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVAR 2403 ++R+ RH NI+LFMG T+P L+IV+++ SLY +H + + + I +A A+ Sbjct: 544 VLRKTRHVNILLFMGYSTKP-QLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQ 602 Query: 2404 GMNCLHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKH--STFLSSKSTAGTPEWM 2577 GM+ LH +I+HRDLKS N+ + ++ TVK+ DFGL+ +K S + +G+ WM Sbjct: 603 GMDYLHAK--SIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWM 660 Query: 2578 APEVLRNEQSNE---KCDIYSFGVILWELATLRKPWHGMNQM-QVVGAVG-------FQD 2724 APEV+R + N + D+Y+FG++L+EL T + P+ +N Q++ VG Sbjct: 661 APEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSK 720 Query: 2725 RRLDIPKEVDPIVASIIRDCWQKDPNLRPSFIQLTSYLKTLQRLVIPSHQETA 2883 R + PK + ++A +C +K + RP F Q+ + ++ L R + H+ + Sbjct: 721 VRSNCPKAMKRLMA----ECLKKKRDERPLFPQILASIELLARSLPKIHRSAS 769
>Q04982:BRAF1_CHICK B-Raf proto-oncogene serine/threonine-protein kinase - Gallus gallus| (Chicken) Length = 806 Score = 146 bits (369), Expect = 5e-34 Identities = 98/293 (33%), Positives = 162/293 (55%), Gaps = 13/293 (4%) Frame = +1 Query: 2044 DEVSECEILWEDLVIDERIGIGSYGEVYHADWNGTEVAVKKFLDQEFYGDALEEFRCEVR 2223 D + EI + + +RIG GS+G VY W+G +VAVK L+ F+ EV Sbjct: 485 DSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHG-DVAVKMLNVTAPTPQQLQAFKNEVG 543 Query: 2224 IMRRLRHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVAR 2403 ++R+ RH NI+LFMG T+P L+IV+++ SLY +H + + + I +A A+ Sbjct: 544 VLRKTRHVNILLFMGYSTKP-QLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQ 602 Query: 2404 GMNCLHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKH--STFLSSKSTAGTPEWM 2577 GM+ LH +I+HRDLKS N+ + ++ TVK+ DFGL+ +K S + +G+ WM Sbjct: 603 GMDYLHAK--SIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWM 660 Query: 2578 APEVLRNEQSNE---KCDIYSFGVILWELATLRKPWHGMNQM-QVVGAVG-------FQD 2724 APEV+R + N + D+Y+FG++L+EL T + P+ +N Q++ VG Sbjct: 661 APEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSK 720 Query: 2725 RRLDIPKEVDPIVASIIRDCWQKDPNLRPSFIQLTSYLKTLQRLVIPSHQETA 2883 R + PK + ++A +C +K + RP F Q+ + ++ L R + H+ + Sbjct: 721 VRSNCPKAMKRLMA----ECLKKKRDERPLFPQILASIELLARSLPKIHRSAS 769
>P00519:ABL1_HUMAN Proto-oncogene tyrosine-protein kinase ABL1 - Homo sapiens (Human)| Length = 1130 Score = 145 bits (365), Expect = 1e-33 Identities = 91/268 (33%), Positives = 144/268 (53%), Gaps = 9/268 (3%) Frame = +1 Query: 2071 WE----DLVIDERIGIGSYGEVYHADWN--GTEVAVKKFLDQEFYGDALEEFRCEVRIMR 2232 WE D+ + ++G G YGEVY W VAVK + +EEF E +M+ Sbjct: 235 WEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTM---EVEEFLKEAAVMK 291 Query: 2233 RLRHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQ-IDEKRRIKMALDVARGM 2409 ++HPN+V +G TR P I++E++ G+L + N Q ++ + MA ++ M Sbjct: 292 EIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAM 351 Query: 2410 NCLHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAGTP-EWMAPE 2586 L +HRDL + N LV +N VKV DFGLSRL ++ + A P +W APE Sbjct: 352 EYLEKK--NFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPE 409 Query: 2587 VLRNEQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIV 2763 L + + K D+++FGV+LWE+AT P+ G++ QV + +D R++ P+ V Sbjct: 410 SLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLE-KDYRMERPEGCPEKV 468 Query: 2764 ASIIRDCWQKDPNLRPSFIQLTSYLKTL 2847 ++R CWQ +P+ RPSF ++ +T+ Sbjct: 469 YELMRACWQWNPSDRPSFAEIHQAFETM 496
>P00521:ABL_MLVAB Tyrosine-protein kinase transforming protein Abl - Abelson murine| leukemia virus Length = 746 Score = 144 bits (364), Expect = 2e-33 Identities = 91/268 (33%), Positives = 143/268 (53%), Gaps = 9/268 (3%) Frame = +1 Query: 2071 WE----DLVIDERIGIGSYGEVYHADWN--GTEVAVKKFLDQEFYGDALEEFRCEVRIMR 2232 WE D+ + ++G G YGEVY W VAVK + +EEF E +M+ Sbjct: 121 WEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTM---EVEEFLKEAAVMK 177 Query: 2233 RLRHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQ-IDEKRRIKMALDVARGM 2409 ++HPN+V +G TR P I++E++ G+L + N Q + + MA ++ M Sbjct: 178 EIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVSAVVLLYMATQISSAM 237 Query: 2410 NCLHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAGTP-EWMAPE 2586 L +HRDL + N LV +N VKV DFGLSRL ++ + A P +W APE Sbjct: 238 EYLEKK--NFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPE 295 Query: 2587 VLRNEQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIV 2763 L + + K D+++FGV+LWE+AT P+ G++ QV + +D R++ P+ V Sbjct: 296 SLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLE-KDYRMERPEGCPEKV 354 Query: 2764 ASIIRDCWQKDPNLRPSFIQLTSYLKTL 2847 ++R CWQ +P+ RPSF ++ +T+ Sbjct: 355 YELMRACWQWNPSDRPSFAEIHQAFETM 382
>P00520:ABL1_MOUSE Proto-oncogene tyrosine-protein kinase ABL1 - Mus musculus (Mouse)| Length = 1123 Score = 144 bits (364), Expect = 2e-33 Identities = 91/268 (33%), Positives = 143/268 (53%), Gaps = 9/268 (3%) Frame = +1 Query: 2071 WE----DLVIDERIGIGSYGEVYHADWN--GTEVAVKKFLDQEFYGDALEEFRCEVRIMR 2232 WE D+ + ++G G YGEVY W VAVK + +EEF E +M+ Sbjct: 235 WEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTM---EVEEFLKEAAVMK 291 Query: 2233 RLRHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQ-IDEKRRIKMALDVARGM 2409 ++HPN+V +G TR P I++E++ G+L + N Q + + MA ++ M Sbjct: 292 EIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVSAVVLLYMATQISSAM 351 Query: 2410 NCLHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAGTP-EWMAPE 2586 L +HRDL + N LV +N VKV DFGLSRL ++ + A P +W APE Sbjct: 352 EYLEKK--NFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPE 409 Query: 2587 VLRNEQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIV 2763 L + + K D+++FGV+LWE+AT P+ G++ QV + +D R++ P+ V Sbjct: 410 SLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLE-KDYRMERPEGCPEKV 468 Query: 2764 ASIIRDCWQKDPNLRPSFIQLTSYLKTL 2847 ++R CWQ +P+ RPSF ++ +T+ Sbjct: 469 YELMRACWQWNPSDRPSFAEIHQAFETM 496
>Q95UN8:M3KSL_DROME Mitogen-activated protein kinase kinase kinase - Drosophila| melanogaster (Fruit fly) Length = 1161 Score = 144 bits (363), Expect = 2e-33 Identities = 94/286 (32%), Positives = 149/286 (52%), Gaps = 13/286 (4%) Frame = +1 Query: 2029 VDLVLDEVSECEILWEDLVIDERIGIGSYGEVYHADWNGTEVAVKKFLDQEFYGDALEEF 2208 V + ++ EI + +L I E IG G + +V+ ++G EVA+K + + D ++ Sbjct: 125 VSSAIGDIQPHEIEYNELDIKEVIGSGGFCKVHRGYYDGEEVAIK--IAHQTGEDDMQRM 182 Query: 2209 RC----EVRIMRRLRHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRR 2376 R E ++ L+H NI G V L +V EY GSL +I+ +I Sbjct: 183 RDNVLQEAKLFWALKHENIAALRG-VCLNTKLCLVMEYARGGSLNRILAG---KIPPDVL 238 Query: 2377 IKMALDVARGMNCLHTSVP-TIVHRDLKSPNLLVDD--------NWTVKVCDFGLSRLKH 2529 + A+ +ARGMN LH P +I+HRDLKS N+L+ + T+K+ DFGL+R + Sbjct: 239 VNWAIQIARGMNYLHNEAPMSIIHRDLKSSNVLIYEAIEGNHLQQKTLKITDFGLAREMY 298 Query: 2530 STFLSSKSTAGTPEWMAPEVLRNEQSNEKCDIYSFGVILWELATLRKPWHGMNQMQVVGA 2709 +T S AGT WM PEV+ ++ D++S+GV+LWEL T P+ G + + V Sbjct: 299 NT--QRMSAAGTYAWMPPEVISVSTYSKFSDVWSYGVLLWELITGETPYKGFDPLSVAYG 356 Query: 2710 VGFQDRRLDIPKEVDPIVASIIRDCWQKDPNLRPSFIQLTSYLKTL 2847 V L IPK ++++ CWQ DP+ RP F ++ L+++ Sbjct: 357 VAVNTLTLPIPKTCPETWGALMKSCWQTDPHKRPGFKEILKQLESI 402
>P09560:RAF1_XENLA RAF proto-oncogene serine/threonine-protein kinase - Xenopus laevis| (African clawed frog) Length = 638 Score = 143 bits (360), Expect = 5e-33 Identities = 100/295 (33%), Positives = 163/295 (55%), Gaps = 9/295 (3%) Frame = +1 Query: 2062 EILWEDLVIDERIGIGSYGEVYHADWNGTEVAVKKFLDQEFYGDALEEFRCEVRIMRRLR 2241 EI+ ++++ RIG GS+G VY W+G +VAVK + + L+ FR EV ++R+ R Sbjct: 334 EIIASEVMLSSRIGSGSFGTVYKGKWHG-DVAVKILKVTDPTPEQLQAFRNEVAVLRKTR 392 Query: 2242 HPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGMNCLH 2421 H NI+LFMG +T+ +L+IV+++ SLY +H + + + I +A A+GM+ LH Sbjct: 393 HVNILLFMGYMTK-DNLAIVTQWCEGSSLYYHLHVLDTKFQMFQLIDIARQTAQGMDYLH 451 Query: 2422 TSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLK--HSTFLSSKSTAGTPEWMAPEVLR 2595 I+HRD+KS N+ + + TVK+ DFGL+ +K S + G+ WMAPEV+R Sbjct: 452 AK--NIIHRDMKSNNIFLHEGLTVKIGDFGLATVKTRWSGSQQVEQLTGSILWMAPEVIR 509 Query: 2596 NEQSNE---KCDIYSFGVILWELATLRKPW-HGMNQMQVVGAVGFQDRRLDIP---KEVD 2754 + +N + D+YS+G++L+EL T P+ H ++ Q++ VG D+ K Sbjct: 510 MQDNNPFSFQSDVYSYGIVLYELMTGELPYSHIRDRDQIIFLVGRGGVVPDLSKLYKNCP 569 Query: 2755 PIVASIIRDCWQKDPNLRPSFIQLTSYLKTLQRLVIPSHQETASNHVPYEISLYR 2919 + ++ D +K + RP F Q+ S ++ LQ H N E SL+R Sbjct: 570 KAMKRLVADSIKKLRDERPLFPQILSSIELLQ------HSLPKINRSALEPSLHR 618
>Q4JIM5:ABL2_MOUSE Tyrosine-protein kinase ABL2 - Mus musculus (Mouse)| Length = 1182 Score = 143 bits (360), Expect = 5e-33 Identities = 99/297 (33%), Positives = 148/297 (49%), Gaps = 11/297 (3%) Frame = +1 Query: 2050 VSECEILWE----DLVIDERIGIGSYGEVYHADWN--GTEVAVKKFLDQEFYGDALEEFR 2211 VS WE D+ + ++G G YGEVY W VAVK F + +EEF Sbjct: 274 VSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTFKEDTM---EVEEFL 330 Query: 2212 CEVRIMRRLRHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRI---K 2382 E +M+ ++HPN+V +G T P IV+EY+P G+L + C +E + Sbjct: 331 KEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLR--ECSREEVTAVVLLY 388 Query: 2383 MALDVARGMNCLHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAG 2562 MA ++ M L +HRDL + N LV +N VKV DFGLSRL ++ + A Sbjct: 389 MATQISSAMEYLEKK--NFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAK 446 Query: 2563 TP-EWMAPEVLRNEQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLD 2736 P +W APE L + K D+++FGV+LWE+AT P+ G++ QV + + R++ Sbjct: 447 FPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLE-KGYRME 505 Query: 2737 IPKEVDPIVASIIRDCWQKDPNLRPSFIQLTSYLKTLQRLVIPSHQETASNHVPYEI 2907 P+ P V ++R CW+ P RPSF + +T+ H + S V E+ Sbjct: 506 QPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETM------FHDSSISEEVAEEL 556
>P10447:ABL_FSVHY Tyrosine-protein kinase transforming protein Abl - Feline sarcoma| virus (strain Hardy-Zuckerman 2) Length = 439 Score = 142 bits (358), Expect = 9e-33 Identities = 89/261 (34%), Positives = 140/261 (53%), Gaps = 9/261 (3%) Frame = +1 Query: 2071 WE----DLVIDERIGIGSYGEVYHADWN--GTEVAVKKFLDQEFYGDALEEFRCEVRIMR 2232 WE D+ + ++G G YGEVY W VAVK + +EEF E +M+ Sbjct: 184 WEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTM---EVEEFLKEAAVMK 240 Query: 2233 RLRHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQ-IDEKRRIKMALDVARGM 2409 ++HPN+V +G TR P I++E++ G+L + N Q ++ + MA ++ M Sbjct: 241 EIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAM 300 Query: 2410 NCLHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRL-KHSTFLSSKSTAGTPEWMAPE 2586 L +HRDL + N LV +N VKV DFGLSRL T+ + T +W APE Sbjct: 301 EYLEKK--NFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGTKFPIKWTAPE 358 Query: 2587 VLRNEQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIV 2763 L + + K D+++FGV+LWE+AT P+ G++ QV + +D R++ P+ V Sbjct: 359 SLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLE-KDYRMERPEGCPEKV 417 Query: 2764 ASIIRDCWQKDPNLRPSFIQL 2826 ++R CWQ +P+ RP+F ++ Sbjct: 418 YELMRACWQWNPSDRPAFAEI 438
>P27446:FYN_XIPHE Proto-oncogene tyrosine-protein kinase FYN - Xiphophorus helleri| Length = 537 Score = 141 bits (356), Expect = 2e-32 Identities = 100/297 (33%), Positives = 154/297 (51%), Gaps = 5/297 (1%) Frame = +1 Query: 1999 VSPSQVGSSKV-DLVLDEVSECEILWEDLVIDERIGIGSYGEVYHADWNGT-EVAVKKFL 2172 V P G ++ DL + EI E L + +R+G G +GEV+ WNGT +VAVK Sbjct: 243 VVPCHKGMPRLADLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGTTKVAVKTLK 302 Query: 2173 DQEFYGDALEEFRCEVRIMRRLRHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPN 2352 + E F E +IM++LRH +V V+ P + IV+EY+ +GSL + Sbjct: 303 PGTM---SPESFLEEAQIMKKLRHDKLVQLYAVVSEEP-IYIVTEYMSKGSLLDFLKDGE 358 Query: 2353 CQ-IDEKRRIKMALDVARGMNCLHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKH 2529 + + + MA VA GM + +HRDL+S N+LV DN K+ DFGL+RL Sbjct: 359 GRALKLPNLVDMAAQVAAGMAYIERM--NYIHRDLRSANILVGDNLVCKIADFGLARLIE 416 Query: 2530 STFLSSKSTAGTP-EWMAPEVLRNEQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVV 2703 +++ A P +W APE + K D++SFG++L EL T R P+ GMN +V+ Sbjct: 417 DNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVL 476 Query: 2704 GAVGFQDRRLDIPKEVDPIVASIIRDCWQKDPNLRPSFIQLTSYLKTLQRLVIPSHQ 2874 V + R+ P++ + ++ CW+KDP RP+F L ++L+ P +Q Sbjct: 477 EQVE-RGYRMPCPQDCPASLHELMLQCWKKDPEERPTFEYLQAFLEDYFTATEPQYQ 532
>P42684:ABL2_HUMAN Tyrosine-protein kinase ABL2 - Homo sapiens (Human)| Length = 1182 Score = 141 bits (355), Expect = 2e-32 Identities = 97/295 (32%), Positives = 147/295 (49%), Gaps = 9/295 (3%) Frame = +1 Query: 2050 VSECEILWE----DLVIDERIGIGSYGEVYHADWN--GTEVAVKKFLDQEFYGDALEEFR 2211 VS WE D+ + ++G G YGEVY W VAVK + +EEF Sbjct: 274 VSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTM---EVEEFL 330 Query: 2212 CEVRIMRRLRHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNC-QIDEKRRIKMA 2388 E +M+ ++HPN+V +G T P IV+EY+P G+L + N ++ + MA Sbjct: 331 KEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMA 390 Query: 2389 LDVARGMNCLHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAGTP 2568 ++ M L +HRDL + N LV +N VKV DFGLSRL ++ + A P Sbjct: 391 TQISSAMEYLEKK--NFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFP 448 Query: 2569 -EWMAPEVLRNEQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIP 2742 +W APE L + K D+++FGV+LWE+AT P+ G++ QV + + R++ P Sbjct: 449 IKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLE-KGYRMEQP 507 Query: 2743 KEVDPIVASIIRDCWQKDPNLRPSFIQLTSYLKTLQRLVIPSHQETASNHVPYEI 2907 + P V ++R CW+ P RPSF + +T+ H + S V E+ Sbjct: 508 EGCPPKVYELMRACWKWSPADRPSFAETHQAFETM------FHDSSISEEVAEEL 556
>O19004:ARAF_PIG A-Raf proto-oncogene serine/threonine-protein kinase - Sus scrofa| (Pig) Length = 606 Score = 140 bits (353), Expect = 3e-32 Identities = 109/347 (31%), Positives = 184/347 (53%), Gaps = 21/347 (6%) Frame = +1 Query: 1942 PRKSPLDRFMDRPRQNIECVSPSQVGSSKVDLVLDEVSECEIL--------WE----DLV 2085 PR SP + R++ SPS+ K + D+ + + L WE ++ Sbjct: 254 PRGSPSPASVSSGRKSPHSKSPSEQRERKS--LADDKKKVKNLGYRDSGYYWEVPPSEVQ 311 Query: 2086 IDERIGIGSYGEVYHADWNGTEVAVKKFLDQEFYGDALEEFRCEVRIMRRLRHPNIVLFM 2265 + +RIG GS+G V+ W+G +VAVK + + + F+ E++++R+ RH NI+LFM Sbjct: 312 LLKRIGTGSFGTVFRGRWHG-DVAVKVLKVAQPTAEQAQAFKNEMQVLRKTRHVNILLFM 370 Query: 2266 GAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGMNCLHTSVPTIVH 2445 G +TR P +I++++ SLY +H + + D + I +A A+GM+ LH I+H Sbjct: 371 GFMTR-PGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAK--NIIH 427 Query: 2446 RDLKSPNLLVDDNWTVKVCDFGLSRLK--HSTFLSSKSTAGTPEWMAPEVLRNEQSNE-- 2613 RDLKS N+ + + TVK+ DFGL+ +K S + +G+ WMA EV+R + N Sbjct: 428 RDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYS 487 Query: 2614 -KCDIYSFGVILWELATLRKPW-HGMNQMQVVGAVGFQDRRLDIPK---EVDPIVASIIR 2778 + D+Y++GV+L+EL T P+ H ++ Q++ VG D+ K + ++ Sbjct: 488 FQSDVYAYGVVLYELMTGSLPYSHIGSRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLS 547 Query: 2779 DCWQKDPNLRPSFIQLTSYLKTLQRLVIPSHQETASNHVPYEISLYR 2919 DC + RP F Q+ + ++ LQR +P + +AS E SL+R Sbjct: 548 DCLKFQREERPLFPQILATIELLQR-SLPKIERSAS-----EPSLHR 588
>P04627:ARAF_MOUSE A-Raf proto-oncogene serine/threonine-protein kinase - Mus musculus| (Mouse) Length = 604 Score = 139 bits (350), Expect = 8e-32 Identities = 109/347 (31%), Positives = 183/347 (52%), Gaps = 21/347 (6%) Frame = +1 Query: 1942 PRKSPLDRFMDRPRQNIECVSPSQVGSSKVDLVLDEVSECEIL--------WE----DLV 2085 PR SP + R++ PS+ K + DE + + L WE ++ Sbjct: 252 PRGSPSPASVSSGRKSPHSKLPSEQRERKS--LADEKKKVKNLGYRDSGYYWEVPPSEVQ 309 Query: 2086 IDERIGIGSYGEVYHADWNGTEVAVKKFLDQEFYGDALEEFRCEVRIMRRLRHPNIVLFM 2265 + +RIG GS+G V+ W+G +VAVK + + + F+ E++++R+ RH NI+LFM Sbjct: 310 LLKRIGTGSFGTVFRGRWHG-DVAVKVLKVAQPTAEQAQAFKNEMQVLRKTRHVNILLFM 368 Query: 2266 GAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGMNCLHTSVPTIVH 2445 G +TR P +I++++ SLY +H + + D + I +A A+GM+ LH I+H Sbjct: 369 GFMTR-PGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAK--NIIH 425 Query: 2446 RDLKSPNLLVDDNWTVKVCDFGLSRLK--HSTFLSSKSTAGTPEWMAPEVLRNEQSNE-- 2613 RDLKS N+ + + TVK+ DFGL+ +K S + +G+ WMA EV+R + N Sbjct: 426 RDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYS 485 Query: 2614 -KCDIYSFGVILWELATLRKPW-HGMNQMQVVGAVGFQDRRLDIPK---EVDPIVASIIR 2778 + D+Y++GV+L+EL T P+ H ++ Q++ VG D+ K + ++ Sbjct: 486 FQSDVYAYGVVLYELMTGSLPYSHIGSRDQIIFMVGRGYLSPDLSKIFSNCPKAMRRLLT 545 Query: 2779 DCWQKDPNLRPSFIQLTSYLKTLQRLVIPSHQETASNHVPYEISLYR 2919 DC + RP F Q+ + ++ LQR +P + +AS E SL+R Sbjct: 546 DCLKFQREERPLFPQILATIELLQR-SLPKIERSAS-----EPSLHR 586
>Q02977:YRK_CHICK Proto-oncogene tyrosine-protein kinase Yrk - Gallus gallus (Chicken)| Length = 536 Score = 139 bits (349), Expect = 1e-31 Identities = 97/295 (32%), Positives = 155/295 (52%), Gaps = 5/295 (1%) Frame = +1 Query: 2005 PSQVGSSKV-DLVLDEVSECEILWEDLVIDERIGIGSYGEVYHADWNGT-EVAVKKFLDQ 2178 P G+ K+ DL + EI E L + +++G G +GEV+ WNGT +VAVK Sbjct: 244 PCPKGTPKLADLSVKTKDVWEIPRESLQLLQKLGNGQFGEVWMGTWNGTTKVAVKTLKPG 303 Query: 2179 EFYGDALEEFRCEVRIMRRLRHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQ 2358 +A E E +IM+RLRH +V V+ P + IV+E++ +GSL + + + Sbjct: 304 TMSPEAFLE---EAQIMKRLRHDKLVQLYAVVSEEP-IYIVTEFMSQGSLLDFLKDGDGR 359 Query: 2359 -IDEKRRIKMALDVARGMNCLHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHST 2535 + + + MA +A GM + +HRDL++ N+LV DN K+ DFGL+RL Sbjct: 360 YLKLPQLVDMAAQIAAGMAYIERM--NYIHRDLRAANILVGDNLVCKIADFGLARLIEDN 417 Query: 2536 FLSSKSTAGTP-EWMAPEVLRNEQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGA 2709 +++ A P +W APE + K D++SFG++L EL T R P+ GMN +V+ Sbjct: 418 EYTARQGAKFPIKWTAPEAALFGKFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQ 477 Query: 2710 VGFQDRRLDIPKEVDPIVASIIRDCWQKDPNLRPSFIQLTSYLKTLQRLVIPSHQ 2874 V + R+ P P + ++ CW+++P RP+F L S+L+ P +Q Sbjct: 478 VE-RGYRMQCPGGCPPSLHDVMVQCWKREPEERPTFEYLQSFLEDYFTATEPQYQ 531
>Q61UC4:KRAF1_CAEBR Raf homolog serine/threonine-protein kinase - Caenorhabditis briggsae| Length = 811 Score = 139 bits (349), Expect = 1e-31 Identities = 96/297 (32%), Positives = 164/297 (55%), Gaps = 16/297 (5%) Frame = +1 Query: 2062 EILWEDLVIDERIGIGSYGEVYHADWNGTEVAVKKFLDQEFYGDALEEFRCEVRIMRRLR 2241 EIL + VI ++G GS+G VY ++ GT VA+KK + + F+ EV ++++ R Sbjct: 473 EILPNEFVIHYKVGSGSFGTVYRGEFFGT-VAIKKLNVVDPTPSQMAAFKNEVAVLKKTR 531 Query: 2242 HPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIH--RPNCQIDEKRRIKMALDVARGMNC 2415 H N++LFMG V R P ++I++++ SLY+ IH P + + I + V+ GMN Sbjct: 532 HLNVLLFMGWV-REPEIAIITQWCEGSSLYRHIHVQEPRVEFEMSAVIDILKQVSLGMNY 590 Query: 2416 LHTSVPTIVHRDLKSPNL-LVDDNWTVKVCDFGLSRLKHSTFLS----SKSTAGTPEWMA 2580 LH+ I+HRDLK+ N+ L+DD TVK+ DFGL+ +K ++ + G+ WMA Sbjct: 591 LHSK--NIIHRDLKTNNIFLMDDMSTVKIGDFGLATVKTKWTVNGGQQQQQPTGSILWMA 648 Query: 2581 PEVLRNEQSN---EKCDIYSFGVILWELATLRKPWHGMNQ----MQVVGAVGFQDRRLDI 2739 PEV+R + N + D+YSFGV ++E+ + P+ +N + +VG + R I Sbjct: 649 PEVIRMQDDNPYTPQSDVYSFGVCMYEILSSHLPYSNINNRDQILFMVGRGYLKPDRSKI 708 Query: 2740 PKEVDPIVASIIRDCWQKDPNLRPSFIQLTSYLKTLQRLVIP--SHQETASNHVPYE 2904 + + + +C D N RP F ++ L+ L+ +++P + ++A N + Y+ Sbjct: 709 RTDTPKSLMKLYDNCIMFDRNERPVFGEV---LERLRDIILPKLTRSQSAPNVLHYD 762
>Q3SWY2:ILK_BOVIN Integrin-linked protein kinase - Bos taurus (Bovine)| Length = 452 Score = 139 bits (349), Expect = 1e-31 Identities = 78/251 (31%), Positives = 136/251 (54%), Gaps = 6/251 (2%) Frame = +1 Query: 2116 GEVYHADWNGTEVAVKKFLDQEFYGDALEEFRCEVRIMRRLRHPNIVLFMGAVTRPP--H 2289 GE++ W G ++ VK +++ +F E +R HPN++ +GA PP H Sbjct: 205 GELWKGRWQGNDIVVKMLKVRDWSTRKSRDFNEECPRLRIFSHPNVLPVLGACQSPPAPH 264 Query: 2290 LSIVSEYLPRGSLYKIIHR-PNCQIDEKRRIKMALDVARGMNCLHTSVPTIVHRDLKSPN 2466 ++++ ++P GSLY ++H N +D+ + +K ALD+ARGM LHT P I L S + Sbjct: 265 PTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMARGMAFLHTLEPLIPRHALNSRS 324 Query: 2467 LLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAGTPEWMAPEVLRN--EQSNEK-CDIYSFG 2637 +++D++ T ++ ++ +K S + A P W+APE L+ E +N + D++SF Sbjct: 325 VMIDEDMTARI---SMADVKFSFQCPGRMYA--PAWVAPEALQKKPEDTNRRSADMWSFA 379 Query: 2638 VILWELATLRKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVASIIRDCWQKDPNLRPSF 2817 V+LWEL T P+ ++ M++ V + R IP + P V +++ C +DP RP F Sbjct: 380 VLLWELVTREVPFADLSNMEIGMKVALEGLRPTIPPGISPHVCKLMKICMNEDPAKRPKF 439 Query: 2818 IQLTSYLKTLQ 2850 + L+ +Q Sbjct: 440 DMIVPILEKMQ 450
>Q99J82:ILK_RAT Integrin-linked protein kinase - Rattus norvegicus (Rat)| Length = 452 Score = 138 bits (348), Expect = 1e-31 Identities = 78/251 (31%), Positives = 136/251 (54%), Gaps = 6/251 (2%) Frame = +1 Query: 2116 GEVYHADWNGTEVAVKKFLDQEFYGDALEEFRCEVRIMRRLRHPNIVLFMGAVTRPP--H 2289 GE++ W G ++ VK +++ +F E +R HPN++ +GA PP H Sbjct: 205 GELWKGRWQGNDIVVKVLKVRDWSTRKSRDFNEECPRLRIFSHPNVLPVLGACQAPPAPH 264 Query: 2290 LSIVSEYLPRGSLYKIIHR-PNCQIDEKRRIKMALDVARGMNCLHTSVPTIVHRDLKSPN 2466 ++++ ++P GSLY ++H N +D+ + +K ALD+ARGM LHT P I L S + Sbjct: 265 PTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMARGMAFLHTLEPLIPRHALNSRS 324 Query: 2467 LLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAGTPEWMAPEVLRN--EQSNEK-CDIYSFG 2637 +++D++ T ++ ++ +K S + A P W+APE L+ E +N + D++SF Sbjct: 325 VMIDEDMTARI---SMADVKFSFQCPGRMYA--PAWVAPEALQKKPEDTNRRSADMWSFA 379 Query: 2638 VILWELATLRKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVASIIRDCWQKDPNLRPSF 2817 V+LWEL T P+ ++ M++ V + R IP + P V +++ C +DP RP F Sbjct: 380 VLLWELVTREVPFADLSNMEIGMKVALEGLRPTIPPGISPHVCKLMKICMNEDPAKRPKF 439 Query: 2818 IQLTSYLKTLQ 2850 + L+ +Q Sbjct: 440 DMIVPILEKMQ 450
>O55222:ILK_MOUSE Integrin-linked protein kinase - Mus musculus (Mouse)| Length = 452 Score = 138 bits (348), Expect = 1e-31 Identities = 78/251 (31%), Positives = 136/251 (54%), Gaps = 6/251 (2%) Frame = +1 Query: 2116 GEVYHADWNGTEVAVKKFLDQEFYGDALEEFRCEVRIMRRLRHPNIVLFMGAVTRPP--H 2289 GE++ W G ++ VK +++ +F E +R HPN++ +GA PP H Sbjct: 205 GELWKGRWQGNDIVVKVLKVRDWSTRKSRDFNEECPRLRIFSHPNVLPVLGACQAPPAPH 264 Query: 2290 LSIVSEYLPRGSLYKIIHR-PNCQIDEKRRIKMALDVARGMNCLHTSVPTIVHRDLKSPN 2466 ++++ ++P GSLY ++H N +D+ + +K ALD+ARGM LHT P I L S + Sbjct: 265 PTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMARGMAFLHTLEPLIPRHALNSRS 324 Query: 2467 LLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAGTPEWMAPEVLRN--EQSNEK-CDIYSFG 2637 +++D++ T ++ ++ +K S + A P W+APE L+ E +N + D++SF Sbjct: 325 VMIDEDMTARI---SMADVKFSFQCPGRMYA--PAWVAPEALQKKPEDTNRRSADMWSFA 379 Query: 2638 VILWELATLRKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVASIIRDCWQKDPNLRPSF 2817 V+LWEL T P+ ++ M++ V + R IP + P V +++ C +DP RP F Sbjct: 380 VLLWELVTREVPFADLSNMEIGMKVALEGLRPTIPPGISPHVCKLMKICMNEDPAKRPKF 439 Query: 2818 IQLTSYLKTLQ 2850 + L+ +Q Sbjct: 440 DMIVPILEKMQ 450
>Q13418:ILK_HUMAN Integrin-linked protein kinase - Homo sapiens (Human)| Length = 452 Score = 138 bits (348), Expect = 1e-31 Identities = 78/251 (31%), Positives = 136/251 (54%), Gaps = 6/251 (2%) Frame = +1 Query: 2116 GEVYHADWNGTEVAVKKFLDQEFYGDALEEFRCEVRIMRRLRHPNIVLFMGAVTRPP--H 2289 GE++ W G ++ VK +++ +F E +R HPN++ +GA PP H Sbjct: 205 GELWKGRWQGNDIVVKVLKVRDWSTRKSRDFNEECPRLRIFSHPNVLPVLGACQSPPAPH 264 Query: 2290 LSIVSEYLPRGSLYKIIHR-PNCQIDEKRRIKMALDVARGMNCLHTSVPTIVHRDLKSPN 2466 ++++ ++P GSLY ++H N +D+ + +K ALD+ARGM LHT P I L S + Sbjct: 265 PTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMARGMAFLHTLEPLIPRHALNSRS 324 Query: 2467 LLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAGTPEWMAPEVLRN--EQSNEK-CDIYSFG 2637 +++D++ T ++ ++ +K S + A P W+APE L+ E +N + D++SF Sbjct: 325 VMIDEDMTARI---SMADVKFSFQCPGRMYA--PAWVAPEALQKKPEDTNRRSADMWSFA 379 Query: 2638 VILWELATLRKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVASIIRDCWQKDPNLRPSF 2817 V+LWEL T P+ ++ M++ V + R IP + P V +++ C +DP RP F Sbjct: 380 VLLWELVTREVPFADLSNMEIGMKVALEGLRPTIPPGISPHVCKLMKICMNEDPAKRPKF 439 Query: 2818 IQLTSYLKTLQ 2850 + L+ +Q Sbjct: 440 DMIVPILEKMQ 450
>P14056:ARAF_RAT A-Raf proto-oncogene serine/threonine-protein kinase - Rattus| norvegicus (Rat) Length = 604 Score = 138 bits (348), Expect = 1e-31 Identities = 96/285 (33%), Positives = 160/285 (56%), Gaps = 9/285 (3%) Frame = +1 Query: 2092 ERIGIGSYGEVYHADWNGTEVAVKKFLDQEFYGDALEEFRCEVRIMRRLRHPNIVLFMGA 2271 +RIG GS+G V+ W+G +VAVK + + + F+ E++++R+ RH NI+LFMG Sbjct: 312 KRIGTGSFGTVFRGRWHG-DVAVKVLKVAQPTAEQAQAFKNEMQVLRKTRHVNILLFMGF 370 Query: 2272 VTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGMNCLHTSVPTIVHRD 2451 +TR P +I++++ SLY +H + + D + I +A A+GM+ LH I+HRD Sbjct: 371 MTR-PGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAK--NIIHRD 427 Query: 2452 LKSPNLLVDDNWTVKVCDFGLSRLK--HSTFLSSKSTAGTPEWMAPEVLRNEQSNE---K 2616 LKS N+ + + TVK+ DFGL+ +K S + +G+ WMA EV+R + N + Sbjct: 428 LKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQ 487 Query: 2617 CDIYSFGVILWELATLRKPW-HGMNQMQVVGAVGFQDRRLDIPK---EVDPIVASIIRDC 2784 D+Y++GV+L+EL T P+ H ++ Q++ VG D+ K + ++ DC Sbjct: 488 SDVYAYGVVLYELMTGSLPYSHIGSRDQIIFMVGRGYLSPDLSKIFSNCPKAMRRLLTDC 547 Query: 2785 WQKDPNLRPSFIQLTSYLKTLQRLVIPSHQETASNHVPYEISLYR 2919 + RP F Q+ + ++ LQR +P + +AS E SL+R Sbjct: 548 LKFQREERPLFPQILATIELLQR-SLPKIERSAS-----EPSLHR 586
>P10398:ARAF_HUMAN A-Raf proto-oncogene serine/threonine-protein kinase - Homo sapiens| (Human) Length = 606 Score = 138 bits (347), Expect = 2e-31 Identities = 108/347 (31%), Positives = 183/347 (52%), Gaps = 21/347 (6%) Frame = +1 Query: 1942 PRKSPLDRFMDRPRQNIECVSPSQVGSSKVDLVLDEVSECEIL--------WE----DLV 2085 PR SP + R++ SP++ K + D+ + + L WE ++ Sbjct: 254 PRGSPSPASVSSGRKSPHSKSPAEQRERKS--LADDKKKVKNLGYRDSGYYWEVPPSEVQ 311 Query: 2086 IDERIGIGSYGEVYHADWNGTEVAVKKFLDQEFYGDALEEFRCEVRIMRRLRHPNIVLFM 2265 + +RIG GS+G V+ W+G +VAVK + + + F+ E++++R+ RH NI+LFM Sbjct: 312 LLKRIGTGSFGTVFRGRWHG-DVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFM 370 Query: 2266 GAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGMNCLHTSVPTIVH 2445 G +TR P +I++++ SLY +H + + D + I +A A+GM+ LH I+H Sbjct: 371 GFMTR-PGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAK--NIIH 427 Query: 2446 RDLKSPNLLVDDNWTVKVCDFGLSRLK--HSTFLSSKSTAGTPEWMAPEVLRNEQSNE-- 2613 RDLKS N+ + + TVK+ DFGL+ +K S + +G+ WMA EV+R + N Sbjct: 428 RDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYS 487 Query: 2614 -KCDIYSFGVILWELATLRKPW-HGMNQMQVVGAVGFQDRRLDIPK---EVDPIVASIIR 2778 + D+Y++GV+L+EL T P+ H + Q++ VG D+ K + ++ Sbjct: 488 FQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLS 547 Query: 2779 DCWQKDPNLRPSFIQLTSYLKTLQRLVIPSHQETASNHVPYEISLYR 2919 DC + RP F Q+ + ++ LQR +P + +AS E SL+R Sbjct: 548 DCLKFQREERPLFPQILATIELLQR-SLPKIERSAS-----EPSLHR 588
>Q5R5V4:ILK_PONPY Integrin-linked protein kinase - Pongo pygmaeus (Orangutan)| Length = 452 Score = 137 bits (346), Expect = 2e-31 Identities = 76/251 (30%), Positives = 134/251 (53%), Gaps = 6/251 (2%) Frame = +1 Query: 2116 GEVYHADWNGTEVAVKKFLDQEFYGDALEEFRCEVRIMRRLRHPNIVLFMGAVTRPP--H 2289 GE++ W G ++ VK +++ +F E +R HPN++ +GA PP H Sbjct: 205 GELWKGRWQGNDIVVKVLKVRDWSTRKSRDFNEECPRLRIFSHPNVLPVLGACQSPPAPH 264 Query: 2290 LSIVSEYLPRGSLYKIIHR-PNCQIDEKRRIKMALDVARGMNCLHTSVPTIVHRDLKSPN 2466 ++++ ++P GSLY ++H N +D+ + +K ALD+ARGM LHT P I L S + Sbjct: 265 PTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMARGMAFLHTLEPLIPRHALNSRS 324 Query: 2467 LLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAGTPEWMAPEVLRNEQSN---EKCDIYSFG 2637 +++D++ T ++ ++ +K S + A P W+APE L+ + + D++SF Sbjct: 325 VMIDEDMTARI---SMADVKFSFQCPGRMYA--PAWVAPEALQKKPEDTNIRSADMWSFA 379 Query: 2638 VILWELATLRKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVASIIRDCWQKDPNLRPSF 2817 V+LWEL T P+ ++ M++ V + R IP + P V +++ C +DP RP F Sbjct: 380 VLLWELVTREVPFADLSNMEIGMRVALEGLRPTIPPGISPHVCKLMKICMNEDPAKRPKF 439 Query: 2818 IQLTSYLKTLQ 2850 + L+ +Q Sbjct: 440 DMIVPILEKMQ 450
>P13406:FYN_XENLA Proto-oncogene tyrosine-protein kinase Fyn - Xenopus laevis (African| clawed frog) Length = 537 Score = 137 bits (344), Expect = 4e-31 Identities = 97/297 (32%), Positives = 154/297 (51%), Gaps = 5/297 (1%) Frame = +1 Query: 1999 VSPSQVGSSKV-DLVLDEVSECEILWEDLVIDERIGIGSYGEVYHADWNG-TEVAVKKFL 2172 V P G ++ DL + EI E L + +R+G G +GEV+ WNG T+VA+K Sbjct: 243 VVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLK 302 Query: 2173 DQEFYGDALEEFRCEVRIMRRLRHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPN 2352 + E F E +IM++L+H +V V+ P + IV+EY+ +GSL + Sbjct: 303 PGTM---SPESFLEEAQIMKKLKHDKLVQLYAVVSEEP-IYIVTEYMSKGSLLDFLKDGE 358 Query: 2353 CQ-IDEKRRIKMALDVARGMNCLHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKH 2529 + + + MA VARGM + +HRDL+S N+LV + K+ DFGL+RL Sbjct: 359 GRALKLPNLVDMAAQVARGMAYIERM--NYIHRDLRSANILVGNGLICKIADFGLARLIE 416 Query: 2530 STFLSSKSTAGTP-EWMAPEVLRNEQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVV 2703 +++ A P +W APE + K D++SFG++L EL T R P+ GMN +V+ Sbjct: 417 DNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVL 476 Query: 2704 GAVGFQDRRLDIPKEVDPIVASIIRDCWQKDPNLRPSFIQLTSYLKTLQRLVIPSHQ 2874 V + R+ P++ + ++ +CW+KDP RP+F L +L+ P +Q Sbjct: 477 EQVE-RGYRMPCPQDCPISLHELMLNCWKKDPEERPTFEYLQGFLEDYFTATEPQYQ 532
>P10936:YES_XENLA Tyrosine-protein kinase Yes - Xenopus laevis (African clawed frog)| Length = 537 Score = 136 bits (342), Expect = 7e-31 Identities = 92/275 (33%), Positives = 148/275 (53%), Gaps = 4/275 (1%) Frame = +1 Query: 2062 EILWEDLVIDERIGIGSYGEVYHADWNGT-EVAVKKFLDQEFYGDALEEFRCEVRIMRRL 2238 EI E L +D ++G G +GEV+ WNGT +VA+K +A F E +IM++L Sbjct: 265 EIPRESLRLDVKLGQGCFGEVWIGTWNGTTKVAIKTLKPGTMMPEA---FLQEAQIMKKL 321 Query: 2239 RHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQ-IDEKRRIKMALDVARGMNC 2415 RH +V V+ P + IV+EY+ +GSL + N + + + + MA +A GM Sbjct: 322 RHDKLVPLYAVVSEEP-IYIVTEYMIKGSLLDFLKEGNGKYLKLPQLVDMAAQIADGMAY 380 Query: 2416 LHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAGTP-EWMAPEVL 2592 + +HRDL++ N+LV DN K+ DFGL+RL +++ A P +W APE Sbjct: 381 IERM--NYIHRDLRAANILVGDNLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAA 438 Query: 2593 RNEQSNEKCDIYSFGVILWEL-ATLRKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVAS 2769 + K D++SFG++L EL A R P+ GM +V+ V + R+ P+ + Sbjct: 439 LYGRFTIKSDVWSFGILLTELVAKGRVPYPGMVNREVLEQVE-RGYRMPCPQRCPESLHE 497 Query: 2770 IIRDCWQKDPNLRPSFIQLTSYLKTLQRLVIPSHQ 2874 +++ CW+KDP+ RP+F + S+L+ P +Q Sbjct: 498 LMKLCWKKDPDERPTFEYIQSFLEDYFTATEPQYQ 532
>P51813:BMX_HUMAN Cytoplasmic tyrosine-protein kinase BMX - Homo sapiens (Human)| Length = 675 Score = 136 bits (342), Expect = 7e-31 Identities = 91/284 (32%), Positives = 147/284 (51%), Gaps = 7/284 (2%) Frame = +1 Query: 2020 SSKVDLVLDEVSECEILWE----DLVIDERIGIGSYGEVYHADWNGT-EVAVKKFLDQEF 2184 S+K + V D VS +WE ++ + + +G G +G V W G +VAVK + Sbjct: 393 STKANKVPDSVSLGNGIWELKREEITLLKELGSGQFGVVQLGKWKGQYDVAVKMIKEGSM 452 Query: 2185 YGDALEEFRCEVRIMRRLRHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQID 2364 D EF E + M +L HP +V F G ++ + IV+EY+ G L + ++ Sbjct: 453 SED---EFFQEAQTMMKLSHPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSHGKGLE 509 Query: 2365 EKRRIKMALDVARGMNCLHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSR-LKHSTFL 2541 + ++M DV GM L + +HRDL + N LVD + VKV DFG++R + ++ Sbjct: 510 PSQLLEMCYDVCEGMAFLESH--QFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYV 567 Query: 2542 SSKSTAGTPEWMAPEVLRNEQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGF 2718 SS T +W APEV + + K D+++FG+++WE+ +L ++P+ + QVV V Sbjct: 568 SSVGTKFPVKWSAPEVFHYFKYSSKSDVWAFGILMWEVFSLGKQPYDLYDNSQVVLKVS- 626 Query: 2719 QDRRLDIPKEVDPIVASIIRDCWQKDPNLRPSFIQLTSYLKTLQ 2850 Q RL P + I+ CW + P RP+F QL S ++ L+ Sbjct: 627 QGHRLYRPHLASDTIYQIMYSCWHELPEKRPTFQQLLSSIEPLR 670
>P27447:YES_XIPHE Tyrosine-protein kinase Yes - Xiphophorus helleri| Length = 544 Score = 135 bits (341), Expect = 9e-31 Identities = 91/275 (33%), Positives = 148/275 (53%), Gaps = 4/275 (1%) Frame = +1 Query: 2062 EILWEDLVIDERIGIGSYGEVYHADWNGT-EVAVKKFLDQEFYGDALEEFRCEVRIMRRL 2238 EI E L +D R+G G +GEV+ WNGT +VA+K +A E E +IM++L Sbjct: 272 EIPRESLRLDVRLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMSPEAFLE---EAQIMKKL 328 Query: 2239 RHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQ-IDEKRRIKMALDVARGMNC 2415 RH +V V+ P + IV+E++ +GSL + + + + + + MA +A GM Sbjct: 329 RHDKLVPLYAVVSEEP-IYIVTEFMGKGSLLDFLKEGDGKHLKLPQLVDMASQIADGMAF 387 Query: 2416 LHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAGTP-EWMAPEVL 2592 + +HRDL++ N+LV DN K+ DFGL+RL +++ A P +W APE Sbjct: 388 IERM--NYIHRDLRAANILVADNLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAA 445 Query: 2593 RNEQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVAS 2769 + K D++SFG++L EL T R P+ GM +V+ V + R+ P+ + Sbjct: 446 LYGRFTIKSDVWSFGILLTELVTKGRVPYPGMVNREVLEQVD-RGYRMPCPQGCPESLHE 504 Query: 2770 IIRDCWQKDPNLRPSFIQLTSYLKTLQRLVIPSHQ 2874 ++R CW+K+P+ RP+F + S+L+ P +Q Sbjct: 505 MMRQCWKKEPDERPTFEYIQSFLEDYFTATEPQYQ 539
>P42686:SRK1_SPOLA Tyrosine-protein kinase isoform SRK1 - Spongilla lacustris| (Freshwater sponge) Length = 505 Score = 135 bits (341), Expect = 9e-31 Identities = 87/257 (33%), Positives = 136/257 (52%), Gaps = 3/257 (1%) Frame = +1 Query: 2056 ECEILWEDLVIDERIGIGSYGEVYHADWNGT-EVAVKKFLDQEFYGDALEEFRCEVRIMR 2232 E EI + + R+G G +GEV+ WNGT VAVK ++EEF E IM+ Sbjct: 232 EWEIEKTQIKLLRRLGAGQFGEVWEGLWNGTTSVAVKTLKPGTM---SVEEFLQEASIMK 288 Query: 2233 RLRHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGMN 2412 RLRHP ++ T+ + IV+E + GSL + + + + ++ + +A VA GM+ Sbjct: 289 RLRHPKLIQLYAVCTKEEPIYIVTELMKYGSLLEYLRGEDGVLKIEQLVDVAAQVASGMS 348 Query: 2413 CLHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAGTP-EWMAPEV 2589 L +HRDL + N+LV ++ KV DFGL+R+ + + A P +W APE Sbjct: 349 YLEQQ--NYIHRDLAARNILVGEHGICKVADFGLARVIDEEIYEAHTGAKFPIKWTAPEA 406 Query: 2590 LRNEQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVA 2766 + K D++SFGV+L+E+ T R P+ GM +V+ + Q+ R+ P Sbjct: 407 AMYNRFTIKSDVWSFGVVLYEIITYGRFPYPGMTNPEVLEKIQ-QNYRMPCPANCPKQFH 465 Query: 2767 SIIRDCWQKDPNLRPSF 2817 I+ DCW++DP RP+F Sbjct: 466 DIMLDCWREDPASRPTF 482
>Q07292:KRAF1_CAEEL Raf homolog serine/threonine-protein kinase - Caenorhabditis elegans| Length = 813 Score = 135 bits (341), Expect = 9e-31 Identities = 91/282 (32%), Positives = 156/282 (55%), Gaps = 14/282 (4%) Frame = +1 Query: 2062 EILWEDLVIDERIGIGSYGEVYHADWNGTEVAVKKFLDQEFYGDALEEFRCEVRIMRRLR 2241 EIL + +I ++G GS+G VY ++ GT VA+KK + + F+ EV ++++ R Sbjct: 475 EILPNEFIIQYKVGSGSFGTVYRGEFFGT-VAIKKLNVVDPTPSQMAAFKNEVAVLKKTR 533 Query: 2242 HPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIH--RPNCQIDEKRRIKMALDVARGMNC 2415 H N++LFMG V R P ++I++++ SLY+ IH P + + I + V+ GMN Sbjct: 534 HLNVLLFMGWV-REPEIAIITQWCEGSSLYRHIHVQEPRVEFEMGAIIDILKQVSLGMNY 592 Query: 2416 LHTSVPTIVHRDLKSPNL-LVDDNWTVKVCDFGLSRLKHSTFLS----SKSTAGTPEWMA 2580 LH+ I+HRDLK+ N+ L+DD TVK+ DFGL+ +K ++ + G+ WMA Sbjct: 593 LHSK--NIIHRDLKTNNIFLMDDMSTVKIGDFGLATVKTKWTVNGGQQQQQPTGSILWMA 650 Query: 2581 PEVLRNEQSN---EKCDIYSFGVILWELATLRKPWHGMNQ----MQVVGAVGFQDRRLDI 2739 PEV+R + N + D+YSFG+ ++E+ + P+ +N + +VG + R I Sbjct: 651 PEVIRMQDDNPYTPQSDVYSFGICMYEILSSHLPYSNINNRDQILFMVGRGYLRPDRSKI 710 Query: 2740 PKEVDPIVASIIRDCWQKDPNLRPSFIQLTSYLKTLQRLVIP 2865 + + + +C D N RP F ++ L+ L+ +++P Sbjct: 711 RHDTPKSMLKLYDNCIMFDRNERPVFGEV---LERLRDIILP 749
>Q9TTY2:FER_CANFA Proto-oncogene tyrosine-protein kinase FER - Canis familiaris (Dog)| Length = 823 Score = 135 bits (341), Expect = 9e-31 Identities = 80/264 (30%), Positives = 132/264 (50%), Gaps = 2/264 (0%) Frame = +1 Query: 2074 EDLVIDERIGIGSYGEVYHADWNGTEVAVKKFLDQEFYGDALEEFRCEVRIMRRLRHPNI 2253 ED+ + E +G G++GEVY K ++ + +F E +I+++ HPNI Sbjct: 561 EDVTLGELLGKGNFGEVYKGILKDKTAVAVKTCKEDLPQELKIKFLQEAKILKQYDHPNI 620 Query: 2254 VLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGMNCLHTSVP 2433 V +G T+ + I+ E +P G + + +I K+ +K +LD A GM+ L + Sbjct: 621 VKLIGVCTQRQPIYIIMELVPGGDFLSFLRKKKDEIKLKQLVKFSLDAASGMSYLESK-- 678 Query: 2434 TIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAGTP-EWMAPEVLRNEQSN 2610 +HRDL + N LV +N +K+ DFG+SR + SS P +W APE L + + Sbjct: 679 NCIHRDLAARNCLVGENNVLKISDFGMSRQEDGGVYSSSGLKQIPIKWTAPEALNYGRYS 738 Query: 2611 EKCDIYSFGVILWELATLRK-PWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVASIIRDCW 2787 + D++SFG++LWE +L P+ GM Q V + R+ P+ + I+ CW Sbjct: 739 SESDVWSFGILLWETFSLGVCPYPGMTNQQATEQVE-RGYRISAPQHCPEDIFKIMMKCW 797 Query: 2788 QKDPNLRPSFIQLTSYLKTLQRLV 2859 P RP F +L L +++ V Sbjct: 798 DYKPENRPKFSELQKELTVIKKKV 821
>P57044:ILK_CAVPO Integrin-linked protein kinase - Cavia porcellus (Guinea pig)| Length = 451 Score = 135 bits (339), Expect = 1e-30 Identities = 78/251 (31%), Positives = 136/251 (54%), Gaps = 6/251 (2%) Frame = +1 Query: 2116 GEVYHADWNGTEVAVKKFLDQEFYGDALEEFRCEVRIMRRLRHPNIVLFMGAVTRPP--H 2289 GE++ W G ++ VK +++ +F E +R HPN++ +GA PP H Sbjct: 205 GELWKGRWQGNDIVVKVLKVRDWSTRKSRDFNEECPRLRIFSHPNVLPVLGACQSPPAPH 264 Query: 2290 LSIVSEYLPRGSLYKIIHR-PNCQIDEKRRIKMALDVARGMNCLHTSVPTIVHRDLKSPN 2466 ++++ ++P GSLY ++H N +D+ + +K ALD+ARGM LHT P I L S + Sbjct: 265 PTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMARGMAFLHTLEPLIPRHALNSRS 324 Query: 2467 LLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAGTPEWMAPEVLRN--EQSNEK-CDIYSFG 2637 +++D++ T ++ ++ +K S + A P W+APE L+ E +N + D++SF Sbjct: 325 VMIDEDMTARI---SMADVKFSFQCPGRMYA--PAWVAPEALQKKPEDTNRRSADMWSFA 379 Query: 2638 VILWELATLRKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVASIIRDCWQKDPNLRPSF 2817 V+LWEL T P+ ++ M++ V + R IP + P V +++ C +DP RP F Sbjct: 380 VLLWELVTREVPFADLSNMEIGMKVALEGRP-TIPPGISPHVCKLMKICMNEDPAKRPKF 438 Query: 2818 IQLTSYLKTLQ 2850 + L+ +Q Sbjct: 439 DMIVPILEKMQ 449
>P06241:FYN_HUMAN Proto-oncogene tyrosine-protein kinase Fyn - Homo sapiens (Human)| Length = 537 Score = 134 bits (338), Expect = 2e-30 Identities = 97/297 (32%), Positives = 153/297 (51%), Gaps = 5/297 (1%) Frame = +1 Query: 1999 VSPSQVGSSKV-DLVLDEVSECEILWEDLVIDERIGIGSYGEVYHADWNG-TEVAVKKFL 2172 V P G ++ DL + EI E L + +R+G G +GEV+ WNG T+VA+K Sbjct: 243 VVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLK 302 Query: 2173 DQEFYGDALEEFRCEVRIMRRLRHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPN 2352 + E F E +IM++L+H +V V+ P + IV+EY+ +GSL + Sbjct: 303 PGTM---SPESFLEEAQIMKKLKHDKLVQLYAVVSEEP-IYIVTEYMNKGSLLDFLKDGE 358 Query: 2353 CQ-IDEKRRIKMALDVARGMNCLHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKH 2529 + + + MA VA GM + +HRDL+S N+LV + K+ DFGL+RL Sbjct: 359 GRALKLPNLVDMAAQVAAGMAYIERM--NYIHRDLRSANILVGNGLICKIADFGLARLIE 416 Query: 2530 STFLSSKSTAGTP-EWMAPEVLRNEQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVV 2703 +++ A P +W APE + K D++SFG++L EL T R P+ GMN +V+ Sbjct: 417 DNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVL 476 Query: 2704 GAVGFQDRRLDIPKEVDPIVASIIRDCWQKDPNLRPSFIQLTSYLKTLQRLVIPSHQ 2874 V + R+ P++ + ++ CW+KDP RP+F L S+L+ P +Q Sbjct: 477 EQVE-RGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQ 532
>Q0VBZ0:CSK_BOVIN Tyrosine-protein kinase CSK - Bos taurus (Bovine)| Length = 450 Score = 134 bits (338), Expect = 2e-30 Identities = 88/263 (33%), Positives = 140/263 (53%), Gaps = 4/263 (1%) Frame = +1 Query: 2074 EDLVIDERIGIGSYGEVYHADWNGTEVAVKKFLDQEFYGDALEEFRCEVRIMRRLRHPNI 2253 +DL + + IG G +G+V D+ G +VAVK + + F E +M +LRH N+ Sbjct: 193 KDLKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDA----TAQAFLAEASVMTQLRHSNL 248 Query: 2254 VLFMGAVTRPPH-LSIVSEYLPRGSLYKIIH-RPNCQIDEKRRIKMALDVARGMNCLHTS 2427 V +G + L IV+EY+ +GSL + R + +K +LDV M L + Sbjct: 249 VQLLGVIVEEKSGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGN 308 Query: 2428 VPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAGTP-EWMAPEVLRNEQ 2604 VHRDL + N+LV ++ KV DFGL++ ST + T P +W APE LR ++ Sbjct: 309 --NFVHRDLAARNVLVSEDNVAKVSDFGLTKEASST----QDTGKLPVKWTAPEALREKK 362 Query: 2605 SNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVASIIRD 2781 + K D++SFG++LWE+ + R P+ + VV V + ++D P P V ++++ Sbjct: 363 FSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVE-KGYKMDAPDGCPPAVYEVMKN 421 Query: 2782 CWQKDPNLRPSFIQLTSYLKTLQ 2850 CW D RPSF+QL L+ ++ Sbjct: 422 CWHLDAATRPSFLQLREQLERIK 444
>P53668:LIMK1_MOUSE LIM domain kinase 1 - Mus musculus (Mouse)| Length = 647 Score = 133 bits (335), Expect = 4e-30 Identities = 94/276 (34%), Positives = 136/276 (49%), Gaps = 18/276 (6%) Frame = +1 Query: 2077 DLVIDERIGIGSYGEVYHADWNGT-EVAVKKFLDQEFYGDALEEFRCEVRIMRRLRHPNI 2253 DL+ E +G G +G+ T EV V K L + F + F EV++MR L HPN+ Sbjct: 338 DLIHGEVLGKGCFGQAIKVTHRETGEVMVMKELIR-FDEETQRTFLKEVKVMRCLEHPNV 396 Query: 2254 VLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGMNCLHTSVP 2433 + F+G + + L+ ++EY+ G+L II + Q +R+ A D+A GM LH+ Sbjct: 397 LKFIGVLYKDKRLNFITEYIKGGTLRGIIKNMDSQYPWSQRVSFAKDIASGMAYLHSM-- 454 Query: 2434 TIVHRDLKSPNLLVDDNWTVKVCDFGLSR--------------LKHSTFLSSKSTAGTPE 2571 I+HRDL S N LV +N V V DFGL+R LK + G P Sbjct: 455 NIIHRDLNSHNCLVRENRNVVVADFGLARLMIDEKNQSEDLRSLKKPDRKKRYTVVGNPY 514 Query: 2572 WMAPEVLRNEQSNEKCDIYSFGVILWEL--ATLRKPWHGMNQMQV-VGAVGFQDRRLDIP 2742 WMAPE++ +EK D++SFG++L E+ P + M + GF DR P Sbjct: 515 WMAPEMINGRSYDEKVDVFSFGIVLCEIIGRVNADPDYLPRTMDFGLNVRGFLDRY--CP 572 Query: 2743 KEVDPIVASIIRDCWQKDPNLRPSFIQLTSYLKTLQ 2850 P I C DP RPSF++L +L+TL+ Sbjct: 573 PNCPPSFFPITVRCCDLDPEKRPSFVKLEQWLETLR 608
>P70451:FER_MOUSE Proto-oncogene tyrosine-protein kinase FER - Mus musculus (Mouse)| Length = 823 Score = 133 bits (335), Expect = 4e-30 Identities = 80/264 (30%), Positives = 134/264 (50%), Gaps = 2/264 (0%) Frame = +1 Query: 2074 EDLVIDERIGIGSYGEVYHADWNGTEVAVKKFLDQEFYGDALEEFRCEVRIMRRLRHPNI 2253 ED+ + E +G G++GEVY K ++ + +F E +I+++ HPNI Sbjct: 562 EDVSLGELLGKGNFGEVYKGTLKDKTPVAIKTCKEDLPQELKIKFLQEAKILKQYDHPNI 621 Query: 2254 VLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGMNCLHTSVP 2433 V +G T+ + I+ E +P G + + ++ K+ ++ +LDVA GM L+ Sbjct: 622 VKLIGVCTQRQPVYIIMELVPGGDFLTFLRKRKDELKLKQLVRFSLDVAAGM--LYLESK 679 Query: 2434 TIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAGTP-EWMAPEVLRNEQSN 2610 +HRDL + N LV +N T+K+ DFG+SR + SS P +W APE L + + Sbjct: 680 NCIHRDLAARNCLVGENNTLKISDFGMSRQEDGGVYSSSGLKQIPIKWTAPEALNYGRYS 739 Query: 2611 EKCDIYSFGVILWELATLRK-PWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVASIIRDCW 2787 + D++SFG++LWE +L P+ GM Q V + R+ P+ V +I+ CW Sbjct: 740 SESDVWSFGILLWETFSLGVCPYPGMTNQQAREQVE-RGYRMSAPQNCPEEVFTIMMKCW 798 Query: 2788 QKDPNLRPSFIQLTSYLKTLQRLV 2859 P RP F L L +++++ Sbjct: 799 DYKPENRPKFNDLHKELTVIKKMI 822
>Q07497:EPHB5_CHICK Ephrin type-B receptor 5 precursor - Gallus gallus (Chicken)| Length = 1002 Score = 133 bits (335), Expect = 4e-30 Identities = 86/267 (32%), Positives = 133/267 (49%), Gaps = 11/267 (4%) Frame = +1 Query: 2086 IDERIGIGSYGEVY-----HADWNGTEVAVKKFLDQEFYGDALEEFRCEVRIMRRLRHPN 2250 I+E IG G +GEV H VA+K L + + EF E IM + HPN Sbjct: 639 IEEVIGSGEFGEVCFGRLKHPGKREYTVAIKT-LKSGYTDEQRREFLSEASIMGQFEHPN 697 Query: 2251 IVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGMNCLHTSV 2430 ++ G VT+ + IV+E++ GSL + + Q + + M +A GM L S Sbjct: 698 VIHLEGVVTKSRPVMIVTEFMENGSLDSFLRQKEGQFSVLQLVGMLRGIAAGMRYL--SD 755 Query: 2431 PTIVHRDLKSPNLLVDDNWTVKVCDFGLSRL-----KHSTFLSSKSTAGTPEWMAPEVLR 2595 VHRDL + N+LV+ N KV DFGLSR + T+ + W APE ++ Sbjct: 756 MNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDASNPTYTGALGCKIPIRWTAPEAVQ 815 Query: 2596 NEQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVASI 2772 + D++S+G+++WE+ + +P+ M+ V+ A+ QD RL P + ++ + Sbjct: 816 YRKFTSSSDVWSYGIVMWEVMSYGERPYWDMSNQDVINAID-QDYRLPPPPDCPTVLHLL 874 Query: 2773 IRDCWQKDPNLRPSFIQLTSYLKTLQR 2853 + DCWQKD RP F Q+ S L + R Sbjct: 875 MLDCWQKDRVQRPKFEQIVSALDKMIR 901
>Q91736:EPB1B_XENLA Ephrin type-B receptor 1-B - Xenopus laevis (African clawed frog)| Length = 902 Score = 133 bits (335), Expect = 4e-30 Identities = 86/266 (32%), Positives = 135/266 (50%), Gaps = 10/266 (3%) Frame = +1 Query: 2086 IDERIGIGSYGEVYHADW---NGTEVAVK-KFLDQEFYGDALEEFRCEVRIMRRLRHPNI 2253 I+E IG G +GEVY + E++V K L + +F E IM + HPNI Sbjct: 539 IEEVIGAGEFGEVYKGRLKLPSKREISVAIKTLKAGYSEKQRRDFLSEASIMGQFDHPNI 598 Query: 2254 VLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGMNCLHTSVP 2433 + G VT+ + I++E++ G+L + + + Q + + M +A GM L S Sbjct: 599 IRLEGVVTKSRPVMIITEFMENGALDSFLRQNDGQFTVIQLVGMLRGIAAGMKYL--SEM 656 Query: 2434 TIVHRDLKSPNLLVDDNWTVKVCDFGLSR-----LKHSTFLSSKSTAGTPEWMAPEVLRN 2598 VHRDL + N+LV+ N KV DFGLSR T+ SS W APE +R Sbjct: 657 NYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTAPEAIRY 716 Query: 2599 EQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVASII 2775 + D++S+G+++WE+ + +P+ M+ V+ A+ QD RL P + + ++ Sbjct: 717 RKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVINAIE-QDYRLPPPMDCPAALHQLM 775 Query: 2776 RDCWQKDPNLRPSFIQLTSYLKTLQR 2853 DCWQKD N RP F ++ + L + R Sbjct: 776 LDCWQKDRNSRPRFGEIVNTLDKMIR 801
>P41240:CSK_HUMAN Tyrosine-protein kinase CSK - Homo sapiens (Human)| Length = 450 Score = 133 bits (335), Expect = 4e-30 Identities = 87/263 (33%), Positives = 141/263 (53%), Gaps = 4/263 (1%) Frame = +1 Query: 2074 EDLVIDERIGIGSYGEVYHADWNGTEVAVKKFLDQEFYGDALEEFRCEVRIMRRLRHPNI 2253 ++L + + IG G +G+V D+ G +VAVK + + F E +M +LRH N+ Sbjct: 193 KELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDA----TAQAFLAEASVMTQLRHSNL 248 Query: 2254 VLFMGAVTRPPH-LSIVSEYLPRGSLYKIIH-RPNCQIDEKRRIKMALDVARGMNCLHTS 2427 V +G + L IV+EY+ +GSL + R + +K +LDV M L + Sbjct: 249 VQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGN 308 Query: 2428 VPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAGTP-EWMAPEVLRNEQ 2604 VHRDL + N+LV ++ KV DFGL++ ST + T P +W APE LR ++ Sbjct: 309 --NFVHRDLAARNVLVSEDNVAKVSDFGLTKEASST----QDTGKLPVKWTAPEALREKK 362 Query: 2605 SNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVASIIRD 2781 + K D++SFG++LWE+ + R P+ + VV V + ++D P P V ++++ Sbjct: 363 FSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVE-KGYKMDAPDGCPPAVYEVMKN 421 Query: 2782 CWQKDPNLRPSFIQLTSYLKTLQ 2850 CW D +RPSF+QL L+ ++ Sbjct: 422 CWHLDAAMRPSFLQLREQLEHIK 444
>P42690:SRK4_SPOLA Tyrosine-protein kinase isoform SRK4 - Spongilla lacustris| (Freshwater sponge) Length = 506 Score = 133 bits (334), Expect = 6e-30 Identities = 88/265 (33%), Positives = 137/265 (51%), Gaps = 3/265 (1%) Frame = +1 Query: 2056 ECEILWEDLVIDERIGIGSYGEVYHADWNGT-EVAVKKFLDQEFYGDALEEFRCEVRIMR 2232 E EI + + + +G G +GEV+ WNGT VAVK ++EEF E IM+ Sbjct: 232 EWEIEKKQIKLLRGLGAGQFGEVWEGLWNGTTSVAVKTLKPGTM---SIEEFLEEASIMK 288 Query: 2233 RLRHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGMN 2412 +LRHP ++ T+ + IV+E + GSL + + + + M VA GM+ Sbjct: 289 QLRHPKLIQLYAVCTKEEPIYIVTELMKHGSLLEYLRGDGRSLKLPDLVDMCSQVASGMS 348 Query: 2413 CLHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAGTP-EWMAPEV 2589 L +HRDL + N+LV ++ KV DFGL+R+ +K A P +W APE Sbjct: 349 YLEQQ--NYIHRDLAARNILVGEHKICKVADFGLARVIDEEIYEAKLGAKFPIKWTAPEA 406 Query: 2590 LRNEQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVA 2766 + K D++SFG++L+E+ T R P+ GM QV+ + Q R+ P + Sbjct: 407 AMYSRFTIKSDVWSFGIVLYEVITYGRFPYPGMTNAQVLEQIQ-QSYRMPRPMGCPEKLY 465 Query: 2767 SIIRDCWQKDPNLRPSFIQLTSYLK 2841 +I+ DCW++DP RP+F L+ L+ Sbjct: 466 AIMMDCWREDPASRPTFETLSWQLE 490
>P53669:LIMK1_RAT LIM domain kinase 1 - Rattus norvegicus (Rat)| Length = 647 Score = 133 bits (334), Expect = 6e-30 Identities = 94/276 (34%), Positives = 136/276 (49%), Gaps = 18/276 (6%) Frame = +1 Query: 2077 DLVIDERIGIGSYGEVYHADWNGT-EVAVKKFLDQEFYGDALEEFRCEVRIMRRLRHPNI 2253 DL+ E +G G +G+ T EV V K L + F + F EV++MR L HPN+ Sbjct: 338 DLIHGEVLGKGCFGQAIKVTHRETGEVMVMKELIR-FDEETQRTFLKEVKVMRCLEHPNV 396 Query: 2254 VLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGMNCLHTSVP 2433 + F+G + + L+ ++EY+ G+L II + Q +R+ A D+A GM LH+ Sbjct: 397 LKFIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSM-- 454 Query: 2434 TIVHRDLKSPNLLVDDNWTVKVCDFGLSR--------------LKHSTFLSSKSTAGTPE 2571 I+HRDL S N LV +N V V DFGL+R LK + G P Sbjct: 455 NIIHRDLNSHNCLVRENRNVVVADFGLARLMIDEKGQSEDLRSLKKPDRKKRYTVVGNPY 514 Query: 2572 WMAPEVLRNEQSNEKCDIYSFGVILWEL--ATLRKPWHGMNQMQV-VGAVGFQDRRLDIP 2742 WMAPE++ +EK D++SFG++L E+ P + M + GF DR P Sbjct: 515 WMAPEMINGRSYDEKVDVFSFGIVLCEIIGRVNADPDYLPRTMDFGLNVRGFLDRY--CP 572 Query: 2743 KEVDPIVASIIRDCWQKDPNLRPSFIQLTSYLKTLQ 2850 P I C DP RPSF++L +L+TL+ Sbjct: 573 PNCPPSFFPITVRCCDLDPEKRPSFVKLEQWLETLR 608
>Q62844:FYN_RAT Proto-oncogene tyrosine-protein kinase Fyn - Rattus norvegicus (Rat)| Length = 537 Score = 133 bits (334), Expect = 6e-30 Identities = 96/297 (32%), Positives = 152/297 (51%), Gaps = 5/297 (1%) Frame = +1 Query: 1999 VSPSQVGSSKV-DLVLDEVSECEILWEDLVIDERIGIGSYGEVYHADWNG-TEVAVKKFL 2172 V P G ++ DL + EI E L + +R+G G +GEV+ WNG T+VA+K Sbjct: 243 VVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLK 302 Query: 2173 DQEFYGDALEEFRCEVRIMRRLRHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPN 2352 + E F E +IM++L+H +V V+ P + IV+EY+ +GSL + Sbjct: 303 PGTM---SPESFLEEAQIMKKLKHDKLVQLYAVVSEEP-IYIVTEYMNKGSLLDFLKDGE 358 Query: 2353 CQ-IDEKRRIKMALDVARGMNCLHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKH 2529 + + + MA VA GM + +HRDL+S N+LV + K+ DFGL+RL Sbjct: 359 GRALKLPNLVDMAAQVAAGMAYIERM--NYIHRDLRSANILVGNGLICKIADFGLARLIE 416 Query: 2530 STFLSSKSTAGTP-EWMAPEVLRNEQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVV 2703 +++ A P +W APE + K D++SFG++L EL T R P+ GMN +V+ Sbjct: 417 DNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVL 476 Query: 2704 GAVGFQDRRLDIPKEVDPIVASIIRDCWQKDPNLRPSFIQLTSYLKTLQRLVIPSHQ 2874 V + R+ P++ + ++ CW+KDP RP+F L +L+ P +Q Sbjct: 477 EQVE-RGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQGFLEDYFTATEPQYQ 532
>A1Y2K1:FYN_PIG Proto-oncogene tyrosine-protein kinase Fyn - Sus scrofa (Pig)| Length = 537 Score = 133 bits (334), Expect = 6e-30 Identities = 96/297 (32%), Positives = 152/297 (51%), Gaps = 5/297 (1%) Frame = +1 Query: 1999 VSPSQVGSSKV-DLVLDEVSECEILWEDLVIDERIGIGSYGEVYHADWNG-TEVAVKKFL 2172 V P G ++ DL + EI E L + +R+G G +GEV+ WNG T+VA+K Sbjct: 243 VVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLK 302 Query: 2173 DQEFYGDALEEFRCEVRIMRRLRHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPN 2352 + E F E +IM++L+H +V V+ P + IV+EY+ +GSL + Sbjct: 303 PGTM---SPESFLEEAQIMKKLKHDKLVQLYAVVSEEP-IYIVTEYMNKGSLLDFLKDGE 358 Query: 2353 CQ-IDEKRRIKMALDVARGMNCLHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKH 2529 + + + MA VA GM + +HRDL+S N+LV + K+ DFGL+RL Sbjct: 359 GRALKLPNLVDMAAQVAAGMAYIERM--NYIHRDLRSANILVGNGLICKIADFGLARLIE 416 Query: 2530 STFLSSKSTAGTP-EWMAPEVLRNEQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVV 2703 +++ A P +W APE + K D++SFG++L EL T R P+ GMN +V+ Sbjct: 417 DNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVL 476 Query: 2704 GAVGFQDRRLDIPKEVDPIVASIIRDCWQKDPNLRPSFIQLTSYLKTLQRLVIPSHQ 2874 V + R+ P++ + ++ CW+KDP RP+F L +L+ P +Q Sbjct: 477 EQVE-RGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQGFLEDYFTATEPQYQ 532
>P39688:FYN_MOUSE Proto-oncogene tyrosine-protein kinase Fyn - Mus musculus (Mouse)| Length = 537 Score = 133 bits (334), Expect = 6e-30 Identities = 96/297 (32%), Positives = 152/297 (51%), Gaps = 5/297 (1%) Frame = +1 Query: 1999 VSPSQVGSSKV-DLVLDEVSECEILWEDLVIDERIGIGSYGEVYHADWNG-TEVAVKKFL 2172 V P G ++ DL + EI E L + +R+G G +GEV+ WNG T+VA+K Sbjct: 243 VVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWLGTWNGNTKVAIKTLK 302 Query: 2173 DQEFYGDALEEFRCEVRIMRRLRHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPN 2352 + E F E +IM++L+H +V V+ P + IV+EY+ +GSL + Sbjct: 303 PGTM---SPESFLEEAQIMKKLKHDKLVQLYAVVSEEP-IYIVTEYMSKGSLLDFLKDGE 358 Query: 2353 CQ-IDEKRRIKMALDVARGMNCLHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKH 2529 + + + MA VA GM + +HRDL+S N+LV + K+ DFGL+RL Sbjct: 359 GRALKLPNLVDMAAQVAAGMAYIERM--NYIHRDLRSANILVGNGLICKIADFGLARLIE 416 Query: 2530 STFLSSKSTAGTP-EWMAPEVLRNEQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVV 2703 +++ A P +W APE + K D++SFG++L EL T R P+ GMN +V+ Sbjct: 417 DNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVL 476 Query: 2704 GAVGFQDRRLDIPKEVDPIVASIIRDCWQKDPNLRPSFIQLTSYLKTLQRLVIPSHQ 2874 V + R+ P++ + ++ CW+KDP RP+F L +L+ P +Q Sbjct: 477 EQVE-RGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQGFLEDYFTATEPQYQ 532
>A0JNB0:FYN_BOVIN Proto-oncogene tyrosine-protein kinase Fyn - Bos taurus (Bovine)| Length = 537 Score = 133 bits (334), Expect = 6e-30 Identities = 96/297 (32%), Positives = 152/297 (51%), Gaps = 5/297 (1%) Frame = +1 Query: 1999 VSPSQVGSSKV-DLVLDEVSECEILWEDLVIDERIGIGSYGEVYHADWNG-TEVAVKKFL 2172 V P G ++ DL + EI E L + +R+G G +GEV+ WNG T+VA+K Sbjct: 243 VVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLK 302 Query: 2173 DQEFYGDALEEFRCEVRIMRRLRHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPN 2352 + E F E +IM++L+H +V V+ P + IV+EY+ +GSL + Sbjct: 303 PGTM---SPESFLEEAQIMKKLKHDKLVQLYAVVSEEP-IYIVTEYMNKGSLLDFLKDGE 358 Query: 2353 CQ-IDEKRRIKMALDVARGMNCLHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKH 2529 + + + MA VA GM + +HRDL+S N+LV + K+ DFGL+RL Sbjct: 359 GRALKLPNLVDMAAQVAAGMAYIERM--NYIHRDLRSANILVGNGLICKIADFGLARLIE 416 Query: 2530 STFLSSKSTAGTP-EWMAPEVLRNEQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVV 2703 +++ A P +W APE + K D++SFG++L EL T R P+ GMN +V+ Sbjct: 417 DNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVL 476 Query: 2704 GAVGFQDRRLDIPKEVDPIVASIIRDCWQKDPNLRPSFIQLTSYLKTLQRLVIPSHQ 2874 V + R+ P++ + ++ CW+KDP RP+F L +L+ P +Q Sbjct: 477 EQVE-RGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQGFLEDYFTATEPQYQ 532
>P09324:YES_CHICK Tyrosine-protein kinase Yes - Gallus gallus (Chicken)| Length = 541 Score = 132 bits (333), Expect = 7e-30 Identities = 89/275 (32%), Positives = 147/275 (53%), Gaps = 4/275 (1%) Frame = +1 Query: 2062 EILWEDLVIDERIGIGSYGEVYHADWNGT-EVAVKKFLDQEFYGDALEEFRCEVRIMRRL 2238 EI E L ++ ++G G +GEV+ WNGT +VA+K +A F E +IM++L Sbjct: 269 EIPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEA---FLQEAQIMKKL 325 Query: 2239 RHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQ-IDEKRRIKMALDVARGMNC 2415 RH +V V+ P + IV+E++ +GSL + + + + + MA +A GM Sbjct: 326 RHDKLVPLYAVVSEEP-IYIVTEFMTKGSLLDFLKEGEGKFLKLPQLVDMAAQIADGMAY 384 Query: 2416 LHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAGTP-EWMAPEVL 2592 + +HRDL++ N+LV DN K+ DFGL+RL +++ A P +W APE Sbjct: 385 IERM--NYIHRDLRAANILVGDNLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAA 442 Query: 2593 RNEQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVAS 2769 + K D++SFG++L EL T R P+ GM +V+ V + R+ P+ + Sbjct: 443 LYGRFTIKSDVWSFGILLTELVTKGRVPYPGMVNREVLEQVE-RGYRMPCPQGCPESLHE 501 Query: 2770 IIRDCWQKDPNLRPSFIQLTSYLKTLQRLVIPSHQ 2874 +++ CW+KDP+ RP+F + S+L+ P +Q Sbjct: 502 LMKLCWKKDPDERPTFEYIQSFLEDYFTATEPQYQ 536
>P00523:SRC_CHICK Proto-oncogene tyrosine-protein kinase Src - Gallus gallus (Chicken)| Length = 533 Score = 132 bits (333), Expect = 7e-30 Identities = 91/275 (33%), Positives = 143/275 (52%), Gaps = 4/275 (1%) Frame = +1 Query: 2062 EILWEDLVIDERIGIGSYGEVYHADWNGT-EVAVKKFLDQEFYGDALEEFRCEVRIMRRL 2238 EI E L ++ ++G G +GEV+ WNGT VA+K +A F E ++M++L Sbjct: 261 EIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEA---FLQEAQVMKKL 317 Query: 2239 RHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIH-RPNCQIDEKRRIKMALDVARGMNC 2415 RH +V V+ P + IV+EY+ +GSL + + + + MA +A GM Sbjct: 318 RHEKLVQLYAVVSEEP-IYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGM-- 374 Query: 2416 LHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAGTP-EWMAPEVL 2592 + VHRDL++ N+LV +N KV DFGL+RL +++ A P +W APE Sbjct: 375 AYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAA 434 Query: 2593 RNEQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVAS 2769 + K D++SFG++L EL T R P+ GM +V+ V + R+ P E + Sbjct: 435 LYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVE-RGYRMPCPPECPESLHD 493 Query: 2770 IIRDCWQKDPNLRPSFIQLTSYLKTLQRLVIPSHQ 2874 ++ CW+KDP RP+F L ++L+ P +Q Sbjct: 494 LMCQCWRKDPEERPTFEYLQAFLEDYFTSTEPQYQ 528
>P53667:LIMK1_HUMAN LIM domain kinase 1 - Homo sapiens (Human)| Length = 647 Score = 132 bits (333), Expect = 7e-30 Identities = 94/276 (34%), Positives = 136/276 (49%), Gaps = 18/276 (6%) Frame = +1 Query: 2077 DLVIDERIGIGSYGEVYHADWNGT-EVAVKKFLDQEFYGDALEEFRCEVRIMRRLRHPNI 2253 DL+ E +G G +G+ T EV V K L + F + F EV++MR L HPN+ Sbjct: 338 DLIHGEVLGKGCFGQAIKVTHRETGEVMVMKELIR-FDEETQRTFLKEVKVMRCLEHPNV 396 Query: 2254 VLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGMNCLHTSVP 2433 + F+G + + L+ ++EY+ G+L II + Q +R+ A D+A GM LH+ Sbjct: 397 LKFIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSM-- 454 Query: 2434 TIVHRDLKSPNLLVDDNWTVKVCDFGLSR--------------LKHSTFLSSKSTAGTPE 2571 I+HRDL S N LV +N V V DFGL+R LK + G P Sbjct: 455 NIIHRDLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPY 514 Query: 2572 WMAPEVLRNEQSNEKCDIYSFGVILWEL--ATLRKPWHGMNQMQV-VGAVGFQDRRLDIP 2742 WMAPE++ +EK D++SFG++L E+ P + M + GF DR P Sbjct: 515 WMAPEMINGRSYDEKVDVFSFGIVLCEIIGRVNADPDYLPRTMDFGLNVRGFLDRY--CP 572 Query: 2743 KEVDPIVASIIRDCWQKDPNLRPSFIQLTSYLKTLQ 2850 P I C DP RPSF++L +L+TL+ Sbjct: 573 PNCPPSFFPITVRCCDLDPEKRPSFVKLEHWLETLR 608
>P16591:FER_HUMAN Proto-oncogene tyrosine-protein kinase FER - Homo sapiens (Human)| Length = 822 Score = 132 bits (333), Expect = 7e-30 Identities = 79/262 (30%), Positives = 131/262 (50%), Gaps = 2/262 (0%) Frame = +1 Query: 2074 EDLVIDERIGIGSYGEVYHADWNGTEVAVKKFLDQEFYGDALEEFRCEVRIMRRLRHPNI 2253 ED+++ E +G G++GEVY K ++ + +F E +I+++ HPNI Sbjct: 561 EDVILGELLGKGNFGEVYKGTLKDKTSVAVKTCKEDLPQELKIKFLQEAKILKQYDHPNI 620 Query: 2254 VLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGMNCLHTSVP 2433 V +G T+ + I+ E + G + R ++ K+ +K +LD A GM L+ Sbjct: 621 VKLIGVCTQRQPVYIIMELVSGGDFLTFLRRKKDELKLKQLVKFSLDAAAGM--LYLESK 678 Query: 2434 TIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAGTP-EWMAPEVLRNEQSN 2610 +HRDL + N LV +N +K+ DFG+SR + SS P +W APE L + + Sbjct: 679 NCIHRDLAARNCLVGENNVLKISDFGMSRQEDGGVYSSSGLKQIPIKWTAPEALNYGRYS 738 Query: 2611 EKCDIYSFGVILWELATLRK-PWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVASIIRDCW 2787 + D++SFG++LWE +L P+ GM Q V + R+ P+ ++ I+ CW Sbjct: 739 SESDVWSFGILLWETFSLGVCPYPGMTNQQAREQVE-RGYRMSAPQHCPEDISKIMMKCW 797 Query: 2788 QKDPNLRPSFIQLTSYLKTLQR 2853 P RP F +L L ++R Sbjct: 798 DYKPENRPKFSELQKELTIIKR 819
>P06240:LCK_MOUSE Proto-oncogene tyrosine-protein kinase LCK - Mus musculus (Mouse)| Length = 509 Score = 132 bits (332), Expect = 9e-30 Identities = 87/265 (32%), Positives = 142/265 (53%), Gaps = 4/265 (1%) Frame = +1 Query: 2056 ECEILWEDLVIDERIGIGSYGEVYHADWNG-TEVAVKKFLDQEFYGDALEEFRCEVRIMR 2232 E E+ E L + ER+G G +GEV+ +NG T+VAVK DA F E +M+ Sbjct: 237 EWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDA---FLAEANLMK 293 Query: 2233 RLRHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPN-CQIDEKRRIKMALDVARGM 2409 +L+HP +V VT+ P + I++EY+ GSL + P+ +++ + + MA +A GM Sbjct: 294 QLQHPRLVRLYAVVTQEP-IYIITEYMENGSLVDFLKTPSGIKLNVNKLLDMAAQIAEGM 352 Query: 2410 NCLHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAGTP-EWMAPE 2586 + +HRDL++ N+LV D + K+ DFGL+RL +++ A P +W APE Sbjct: 353 AFIEEQ--NYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPE 410 Query: 2587 VLRNEQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIV 2763 + K D++SFG++L E+ T R P+ GM +V+ + + R+ P + Sbjct: 411 AINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLE-RGYRMVRPDNCPEEL 469 Query: 2764 ASIIRDCWQKDPNLRPSFIQLTSYL 2838 ++ CW++ P RP+F L S L Sbjct: 470 YHLMMLCWKERPEDRPTFDYLRSVL 494
>Q05876:FYN_CHICK Proto-oncogene tyrosine-protein kinase Fyn - Gallus gallus (Chicken)| Length = 534 Score = 132 bits (332), Expect = 9e-30 Identities = 88/275 (32%), Positives = 145/275 (52%), Gaps = 4/275 (1%) Frame = +1 Query: 2062 EILWEDLVIDERIGIGSYGEVYHADWNG-TEVAVKKFLDQEFYGDALEEFRCEVRIMRRL 2238 E+ + L +++++G G + EV+ WNG T+VA+K + E F E +IM++L Sbjct: 262 EVARDSLFLEQKLGQGCFAEVWRGTWNGNTKVAIKTLKPGTM---SPESFLEEAQIMKKL 318 Query: 2239 RHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQ-IDEKRRIKMALDVARGMNC 2415 +H +V V+R P + IV+EY+ +GSL + + + + MA VA GM Sbjct: 319 KHDKLVQLYAVVSRRP-IYIVTEYMSKGSLLIFLKDGEGRALKLPNLVDMAAQVAAGMAY 377 Query: 2416 LHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAGTP-EWMAPEVL 2592 + +HRDL+S N+LV + K+ DFGL+RL +++ A P +W APE Sbjct: 378 IERM--NYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAA 435 Query: 2593 RNEQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVAS 2769 + K D++SFG++L EL T R P+ GMN +V+ V + R+ P++ + Sbjct: 436 LYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVE-RGYRMPCPQDCPISLHE 494 Query: 2770 IIRDCWQKDPNLRPSFIQLTSYLKTLQRLVIPSHQ 2874 ++ CW+KDP RP+F L +L+ P +Q Sbjct: 495 LMIHCWKKDPEERPTFEYLQGFLEDYFTATEPQYQ 529
>P09760:FER_RAT Proto-oncogene tyrosine-protein kinase FER - Rattus norvegicus (Rat)| Length = 323 Score = 132 bits (332), Expect = 9e-30 Identities = 79/264 (29%), Positives = 133/264 (50%), Gaps = 2/264 (0%) Frame = +1 Query: 2074 EDLVIDERIGIGSYGEVYHADWNGTEVAVKKFLDQEFYGDALEEFRCEVRIMRRLRHPNI 2253 ED+ + E +G G++GEVY K ++ + +F E +I+++ HPNI Sbjct: 62 EDVSLGELLGKGNFGEVYKGTLKDKTPVAVKTCKEDLPQELKIKFLQEAKILKQYDHPNI 121 Query: 2254 VLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGMNCLHTSVP 2433 V +G T+ + I+ E +P G + + ++ K+ ++ +LDVA GM L+ Sbjct: 122 VKLIGVCTQRQPVYIIMELVPGGDFLSFLRKRKDELKLKQLVRFSLDVAAGM--LYLEGK 179 Query: 2434 TIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAGTP-EWMAPEVLRNEQSN 2610 +HRDL + N LV +N T+K+ DFG+SR + SS P +W APE L + + Sbjct: 180 NCIHRDLAARNCLVGENNTLKISDFGMSRQEDGGVYSSSGLKQIPIKWTAPEALNYGRYS 239 Query: 2611 EKCDIYSFGVILWELATLRK-PWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVASIIRDCW 2787 + D++SFG++LWE +L P+ GM Q V + R+ P+ + +I+ CW Sbjct: 240 SESDVWSFGILLWETFSLGVCPYPGMTNQQAREQVE-RGYRMSAPQNCPEEIFTIMMKCW 298 Query: 2788 QKDPNLRPSFIQLTSYLKTLQRLV 2859 P RP F L L +++ + Sbjct: 299 DYKPENRPKFSDLHKELTAIKKKI 322
>P97504:BMX_MOUSE Cytoplasmic tyrosine-protein kinase BMX - Mus musculus (Mouse)| Length = 651 Score = 132 bits (332), Expect = 9e-30 Identities = 84/266 (31%), Positives = 141/266 (53%), Gaps = 3/266 (1%) Frame = +1 Query: 2062 EILWEDLVIDERIGIGSYGEVYHADWNGT-EVAVKKFLDQEFYGDALEEFRCEVRIMRRL 2238 E+ E++ + + +G G +G V W G +VAVK + D EF E + M +L Sbjct: 387 ELKREEITLLKELGNGQFGVVQLGQWKGQYDVAVKMIKEGAMSED---EFFQEAQTMMKL 443 Query: 2239 RHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGMNCL 2418 HP +V F G ++ + IV+EY+ G L + ++ + ++M DV GM L Sbjct: 444 SHPKLVKFYGVCSKKYPIYIVTEYITNGCLLNYLKSHGKGLESCQLLEMCYDVCEGMAFL 503 Query: 2419 HTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSR-LKHSTFLSSKSTAGTPEWMAPEVLR 2595 + +HRDL + N LVD + +VKV DFG++R + ++SS T +W APEV Sbjct: 504 ESH--QFIHRDLAARNCLVDSDLSVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFH 561 Query: 2596 NEQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVASI 2772 + + K D+++FG+++WE+ +L ++P+ + +VV V Q RL P+ + I Sbjct: 562 YFKYSSKSDVWAFGILMWEVFSLGKQPYDLYDNSEVVVKVS-QGHRLYRPQLASDTIYQI 620 Query: 2773 IRDCWQKDPNLRPSFIQLTSYLKTLQ 2850 + CW + P RP+F QL S ++ L+ Sbjct: 621 MYSCWHELPEKRPTFQQLLSAIEPLR 646
>P12931:SRC_HUMAN Proto-oncogene tyrosine-protein kinase Src - Homo sapiens (Human)| Length = 536 Score = 131 bits (330), Expect = 2e-29 Identities = 90/275 (32%), Positives = 144/275 (52%), Gaps = 4/275 (1%) Frame = +1 Query: 2062 EILWEDLVIDERIGIGSYGEVYHADWNGT-EVAVKKFLDQEFYGDALEEFRCEVRIMRRL 2238 EI E L ++ ++G G +GEV+ WNGT VA+K +A F E ++M++L Sbjct: 264 EIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEA---FLQEAQVMKKL 320 Query: 2239 RHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQ-IDEKRRIKMALDVARGMNC 2415 RH +V V+ P + IV+EY+ +GSL + + + + + MA +A GM Sbjct: 321 RHEKLVQLYAVVSEEP-IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGM-- 377 Query: 2416 LHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAGTP-EWMAPEVL 2592 + VHRDL++ N+LV +N KV DFGL+RL +++ A P +W APE Sbjct: 378 AYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAA 437 Query: 2593 RNEQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVAS 2769 + K D++SFG++L EL T R P+ GM +V+ V + R+ P E + Sbjct: 438 LYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVE-RGYRMPCPPECPESLHD 496 Query: 2770 IIRDCWQKDPNLRPSFIQLTSYLKTLQRLVIPSHQ 2874 ++ CW+K+P RP+F L ++L+ P +Q Sbjct: 497 LMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQ 531
>P14085:SRC_AVIST Tyrosine-protein kinase transforming protein Src - Avian sarcoma| virus (strain S2) Length = 557 Score = 131 bits (330), Expect = 2e-29 Identities = 89/264 (33%), Positives = 140/264 (53%), Gaps = 4/264 (1%) Frame = +1 Query: 2062 EILWEDLVIDERIGIGSYGEVYHADWNGT-EVAVKKFLDQEFYGDALEEFRCEVRIMRRL 2238 EI E L ++ ++G G +GEV+ WNGT VA+K +A F E ++M++L Sbjct: 261 EIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEA---FLQEAQVMKKL 317 Query: 2239 RHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIH-RPNCQIDEKRRIKMALDVARGMNC 2415 RH +V V+ P + IV+EY+ +GSL + + + + MA +A GM Sbjct: 318 RHEKLVQLYAVVSEEP-IYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGM-- 374 Query: 2416 LHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAGTP-EWMAPEVL 2592 + VHRDL++ N+LV +N KV DFGL+RL +++ A P +W APE Sbjct: 375 AYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAA 434 Query: 2593 RNEQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVAS 2769 + K D++SFG++L EL T R P+ GM +V+ V + R+ P E + Sbjct: 435 LYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVE-RGYRMPCPPECPESLHD 493 Query: 2770 IIRDCWQKDPNLRPSFIQLTSYLK 2841 ++ CW+KDP RP+F L ++L+ Sbjct: 494 LMCQCWRKDPEERPTFEYLQAFLE 517
>P14084:SRC_AVISS Tyrosine-protein kinase transforming protein Src - Avian sarcoma| virus (strain S1) Length = 568 Score = 131 bits (330), Expect = 2e-29 Identities = 89/264 (33%), Positives = 140/264 (53%), Gaps = 4/264 (1%) Frame = +1 Query: 2062 EILWEDLVIDERIGIGSYGEVYHADWNGT-EVAVKKFLDQEFYGDALEEFRCEVRIMRRL 2238 EI E L ++ ++G G +GEV+ WNGT VA+K +A F E ++M++L Sbjct: 261 EIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEA---FLQEAQVMKKL 317 Query: 2239 RHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIH-RPNCQIDEKRRIKMALDVARGMNC 2415 RH +V V+ P + IV+EY+ +GSL + + + + MA +A GM Sbjct: 318 RHEKLVRLYAVVSEEP-IYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGM-- 374 Query: 2416 LHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAGTP-EWMAPEVL 2592 + VHRDL++ N+LV +N KV DFGL+RL +++ A P +W APE Sbjct: 375 AYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAA 434 Query: 2593 RNEQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVAS 2769 + K D++SFG++L EL T R P+ GM +V+ V + R+ P E + Sbjct: 435 LYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVE-RGYRMPCPPECPESLHD 493 Query: 2770 IIRDCWQKDPNLRPSFIQLTSYLK 2841 ++ CW+KDP RP+F L ++L+ Sbjct: 494 LMCQCWRKDPEERPTFEYLQAFLE 517
>P15054:SRC_AVIS2 Tyrosine-protein kinase transforming protein Src - Avian sarcoma| virus (strain PR2257) Length = 587 Score = 131 bits (330), Expect = 2e-29 Identities = 89/264 (33%), Positives = 140/264 (53%), Gaps = 4/264 (1%) Frame = +1 Query: 2062 EILWEDLVIDERIGIGSYGEVYHADWNGT-EVAVKKFLDQEFYGDALEEFRCEVRIMRRL 2238 EI E L ++ ++G G +GEV+ WNGT VA+K +A F E ++M++L Sbjct: 261 EIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEA---FLQEAQVMKKL 317 Query: 2239 RHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIH-RPNCQIDEKRRIKMALDVARGMNC 2415 RH +V V+ P + IV+EY+ +GSL + + + + MA +A GM Sbjct: 318 RHEKLVQLYAVVSEEP-IYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGM-- 374 Query: 2416 LHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAGTP-EWMAPEVL 2592 + VHRDL++ N+LV +N KV DFGL+RL +++ A P +W APE Sbjct: 375 AYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAA 434 Query: 2593 RNEQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVAS 2769 + K D++SFG++L EL T R P+ GM +V+ V + R+ P E + Sbjct: 435 LYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVE-RGYRMPCPPECPESLHD 493 Query: 2770 IIRDCWQKDPNLRPSFIQLTSYLK 2841 ++ CW+KDP RP+F L ++L+ Sbjct: 494 LMCQCWRKDPEERPTFEYLQAFLE 517
>P09759:EPHB1_RAT Ephrin type-B receptor 1 precursor - Rattus norvegicus (Rat)| Length = 984 Score = 131 bits (329), Expect = 2e-29 Identities = 85/266 (31%), Positives = 132/266 (49%), Gaps = 10/266 (3%) Frame = +1 Query: 2086 IDERIGIGSYGEVYHADWN---GTEVAVK-KFLDQEFYGDALEEFRCEVRIMRRLRHPNI 2253 I+E IG G +GEVY E+ V K L + +F E IM + HPNI Sbjct: 621 IEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRDFLSEASIMGQFDHPNI 680 Query: 2254 VLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGMNCLHTSVP 2433 + G VT+ + I++E++ G+L + + + Q + + M +A GM L S Sbjct: 681 IRLEGVVTKSRPVMIITEFMENGALDSFLRQNDGQFTVIQLVGMLRGIAAGMKYL--SEM 738 Query: 2434 TIVHRDLKSPNLLVDDNWTVKVCDFGLSR-----LKHSTFLSSKSTAGTPEWMAPEVLRN 2598 VHRDL + N+LV+ N KV DFGLSR T+ SS W APE + Sbjct: 739 NYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTAPEAIAY 798 Query: 2599 EQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVASII 2775 + D++S+G+++WE+ + +P+ M+ V+ A+ QD RL P + + ++ Sbjct: 799 RKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIE-QDYRLPPPMDCPAALHQLM 857 Query: 2776 RDCWQKDPNLRPSFIQLTSYLKTLQR 2853 DCWQKD N RP F ++ + L + R Sbjct: 858 LDCWQKDRNSRPRFAEIVNTLDKMIR 883
>Q8CBF3:EPHB1_MOUSE Ephrin type-B receptor 1 precursor - Mus musculus (Mouse)| Length = 984 Score = 131 bits (329), Expect = 2e-29 Identities = 85/266 (31%), Positives = 132/266 (49%), Gaps = 10/266 (3%) Frame = +1 Query: 2086 IDERIGIGSYGEVYHADWN---GTEVAVK-KFLDQEFYGDALEEFRCEVRIMRRLRHPNI 2253 I+E IG G +GEVY E+ V K L + +F E IM + HPNI Sbjct: 621 IEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRDFLSEASIMGQFDHPNI 680 Query: 2254 VLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGMNCLHTSVP 2433 + G VT+ + I++E++ G+L + + + Q + + M +A GM L S Sbjct: 681 IRLEGVVTKSRPVMIITEFMENGALDSFLRQNDGQFTVIQLVGMLRGIAAGMKYL--SEM 738 Query: 2434 TIVHRDLKSPNLLVDDNWTVKVCDFGLSR-----LKHSTFLSSKSTAGTPEWMAPEVLRN 2598 VHRDL + N+LV+ N KV DFGLSR T+ SS W APE + Sbjct: 739 NYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTAPEAIAY 798 Query: 2599 EQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVASII 2775 + D++S+G+++WE+ + +P+ M+ V+ A+ QD RL P + + ++ Sbjct: 799 RKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIE-QDYRLPPPMDCPAALHQLM 857 Query: 2776 RDCWQKDPNLRPSFIQLTSYLKTLQR 2853 DCWQKD N RP F ++ + L + R Sbjct: 858 LDCWQKDRNSRPRFAEIVNTLDKMIR 883
>O08680:EPHA3_RAT Ephrin type-A receptor 3 precursor - Rattus norvegicus (Rat)| Length = 984 Score = 131 bits (329), Expect = 2e-29 Identities = 86/267 (32%), Positives = 136/267 (50%), Gaps = 8/267 (2%) Frame = +1 Query: 2077 DLVIDERIGIGSYGEVYHADW---NGTEVAVK-KFLDQEFYGDALEEFRCEVRIMRRLRH 2244 ++ ID+ +G G +GEV + E++V K L + +F E IM + H Sbjct: 621 NIAIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRRDFLGEASIMGQFDH 680 Query: 2245 PNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGMNCLHT 2424 PNI+ G VT+ + IV+EY+ GSL + + + Q + + M +A GM L Sbjct: 681 PNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFTVIQLVGMLRGIASGMKYL-- 738 Query: 2425 SVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAG---TPEWMAPEVLR 2595 S VHRDL + N+L++ N KV DFGLSR+ ++ +T G W +PE Sbjct: 739 SDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPVRWTSPEATA 798 Query: 2596 NEQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVASI 2772 + D++S+G++LWE+ + +P+ M+ V+ AV + RL +P + + + Sbjct: 799 YRKFTSASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVD-EGYRLPLPMDCPAALYQL 857 Query: 2773 IRDCWQKDPNLRPSFIQLTSYLKTLQR 2853 + DCWQKD N RP F Q+ S L L R Sbjct: 858 MLDCWQKDRNNRPKFEQIVSILDKLIR 884
>P32577:CSK_RAT Tyrosine-protein kinase CSK - Rattus norvegicus (Rat)| Length = 450 Score = 131 bits (329), Expect = 2e-29 Identities = 86/263 (32%), Positives = 140/263 (53%), Gaps = 4/263 (1%) Frame = +1 Query: 2074 EDLVIDERIGIGSYGEVYHADWNGTEVAVKKFLDQEFYGDALEEFRCEVRIMRRLRHPNI 2253 ++L + + IG G +G+V D+ G +VAVK + + F E +M +LRH N+ Sbjct: 193 KELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDA----TAQAFLAEASVMTQLRHSNL 248 Query: 2254 VLFMGAVTRPPH-LSIVSEYLPRGSLYKIIH-RPNCQIDEKRRIKMALDVARGMNCLHTS 2427 V +G + L IV+EY+ +GSL + R + +K +LDV M L + Sbjct: 249 VQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGN 308 Query: 2428 VPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAGTP-EWMAPEVLRNEQ 2604 VHRDL + N+LV ++ KV DFGL++ ST + T P +W APE LR ++ Sbjct: 309 --NFVHRDLAARNVLVSEDNVAKVSDFGLTKEASST----QDTGKLPVKWTAPEALREKK 362 Query: 2605 SNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVASIIRD 2781 + K D++SFG++LWE+ + R P+ + VV V + ++D P P V ++++ Sbjct: 363 FSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVE-KGYKMDAPDGCPPAVYDVMKN 421 Query: 2782 CWQKDPNLRPSFIQLTSYLKTLQ 2850 CW D RP+F+QL L+ ++ Sbjct: 422 CWHLDAATRPTFLQLREQLEHIR 444
>P41239:CSK_CHICK Tyrosine-protein kinase CSK - Gallus gallus (Chicken)| Length = 450 Score = 131 bits (329), Expect = 2e-29 Identities = 89/259 (34%), Positives = 136/259 (52%), Gaps = 4/259 (1%) Frame = +1 Query: 2074 EDLVIDERIGIGSYGEVYHADWNGTEVAVKKFLDQEFYGDALEEFRCEVRIMRRLRHPNI 2253 +DL + + IG G +G+V D+ G +VAVK + + F E +M +LRH N+ Sbjct: 193 KDLKLLQIIGKGEFGDVMLGDYRGNKVAVKCIKNDA----TAQAFLAEASVMTQLRHSNL 248 Query: 2254 VLFMGAVTRPPH-LSIVSEYLPRGSLYKIIH-RPNCQIDEKRRIKMALDVARGMNCLHTS 2427 V +G + L IV+EY+ +GSL + R + +K +LDV M L + Sbjct: 249 VQLLGVIVEEKSGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEAN 308 Query: 2428 VPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAGTP-EWMAPEVLRNEQ 2604 VHRDL + N+LV ++ KV DFGL++ ST + T P +W APE LR ++ Sbjct: 309 --NFVHRDLAARNVLVSEDNIAKVSDFGLTKEASST----QDTGKLPVKWTAPEALREKK 362 Query: 2605 SNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVASIIRD 2781 + K D++SFG++LWE+ + R P+ + VV V + ++D P IV +++ Sbjct: 363 FSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVE-KGYKMDPPDGCPAIVYEVMKK 421 Query: 2782 CWQKDPNLRPSFIQLTSYL 2838 CW DP RPSF QL L Sbjct: 422 CWTLDPGHRPSFHQLREQL 440
>P06239:LCK_HUMAN Proto-oncogene tyrosine-protein kinase LCK - Homo sapiens (Human)| Length = 509 Score = 130 bits (328), Expect = 3e-29 Identities = 87/266 (32%), Positives = 142/266 (53%), Gaps = 4/266 (1%) Frame = +1 Query: 2056 ECEILWEDLVIDERIGIGSYGEVYHADWNG-TEVAVKKFLDQEFYGDALEEFRCEVRIMR 2232 E E+ E L + ER+G G +GEV+ +NG T+VAVK DA F E +M+ Sbjct: 237 EWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDA---FLAEANLMK 293 Query: 2233 RLRHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPN-CQIDEKRRIKMALDVARGM 2409 +L+H +V VT+ P + I++EY+ GSL + P+ ++ + + MA +A GM Sbjct: 294 QLQHQRLVRLYAVVTQEP-IYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGM 352 Query: 2410 NCLHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAGTP-EWMAPE 2586 + +HRDL++ N+LV D + K+ DFGL+RL +++ A P +W APE Sbjct: 353 AFIEER--NYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPE 410 Query: 2587 VLRNEQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIV 2763 + K D++SFG++L E+ T R P+ GM +V+ + + R+ P + Sbjct: 411 AINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLE-RGYRMVRPDNCPEEL 469 Query: 2764 ASIIRDCWQKDPNLRPSFIQLTSYLK 2841 ++R CW++ P RP+F L S L+ Sbjct: 470 YQLMRLCWKERPEDRPTFDYLRSVLE 495
>P00527:YES_AVISY Tyrosine-protein kinase transforming protein YES - Avian sarcoma| virus (strain Y73) Length = 528 Score = 130 bits (327), Expect = 4e-29 Identities = 89/273 (32%), Positives = 146/273 (53%), Gaps = 4/273 (1%) Frame = +1 Query: 2062 EILWEDLVIDERIGIGSYGEVYHADWNGT-EVAVKKFLDQEFYGDALEEFRCEVRIMRRL 2238 EI E L ++ ++G G +GEV+ WNGT +VA+K +A F E +IM++L Sbjct: 261 EIPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKLGTMMPEA---FLQEAQIMKKL 317 Query: 2239 RHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQ-IDEKRRIKMALDVARGMNC 2415 RH +V V+ P + IV+E++ +GSL + + + + + MA +A GM Sbjct: 318 RHDKLVPLYAVVSEEP-IYIVTEFMTKGSLLDFLKEGEGKFLKLPQLVDMAAQIADGMAY 376 Query: 2416 LHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAGTP-EWMAPEVL 2592 + +HRDL++ N+LV DN K+ DFGL+RL +++ A P +W APE Sbjct: 377 IERM--NYIHRDLRAANILVGDNLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAA 434 Query: 2593 RNEQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVAS 2769 + K D++SFG++L EL T R P+ GM +V+ V + R+ P+ + Sbjct: 435 LYGRFTIKSDVWSFGILLTELVTKGRVPYPGMVNREVLEQVE-RGYRMPCPQGCPESLHE 493 Query: 2770 IIRDCWQKDPNLRPSFIQLTSYLKTLQRLVIPS 2868 +++ CW+KDP+ RP+F + S+L+ PS Sbjct: 494 LMKLCWKKDPDERPTFEYIQSFLEDYFTAAEPS 526
>P13116:SRC2_XENLA Tyrosine-protein kinase Src-2 - Xenopus laevis (African clawed frog)| Length = 532 Score = 130 bits (327), Expect = 4e-29 Identities = 89/275 (32%), Positives = 143/275 (52%), Gaps = 4/275 (1%) Frame = +1 Query: 2062 EILWEDLVIDERIGIGSYGEVYHADWNGT-EVAVKKFLDQEFYGDALEEFRCEVRIMRRL 2238 EI + L ++ ++G G +GEV+ WNGT VA+K +A F E ++M++L Sbjct: 260 EIPRDSLRLELKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEA---FLQEAQVMKKL 316 Query: 2239 RHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIH-RPNCQIDEKRRIKMALDVARGMNC 2415 RH +V V+ P + IV+EY+ +GSL + + + + MA +A GM Sbjct: 317 RHEKLVQLYAVVSEEP-IYIVTEYMSKGSLLDFLKGEMGRYLRLPQLVDMAAQIASGM-- 373 Query: 2416 LHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAGTP-EWMAPEVL 2592 + VHRDL++ N+LV +N KV DFGL+RL +++ A P +W APE Sbjct: 374 AYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAA 433 Query: 2593 RNEQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVAS 2769 + K D++SFG++L EL T R P+ GM +V+ V + R+ P + + Sbjct: 434 LYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVE-RGYRMPCPPDCPESLHD 492 Query: 2770 IIRDCWQKDPNLRPSFIQLTSYLKTLQRLVIPSHQ 2874 ++ CW+KDP RP+F L ++L+ P +Q Sbjct: 493 LMFQCWRKDPEERPTFEYLQAFLEDYFTATEPQYQ 527
>P13115:SRC1_XENLA Tyrosine-protein kinase Src-1 - Xenopus laevis (African clawed frog)| Length = 532 Score = 130 bits (327), Expect = 4e-29 Identities = 89/275 (32%), Positives = 143/275 (52%), Gaps = 4/275 (1%) Frame = +1 Query: 2062 EILWEDLVIDERIGIGSYGEVYHADWNGT-EVAVKKFLDQEFYGDALEEFRCEVRIMRRL 2238 EI + L ++ ++G G +GEV+ WNGT VA+K +A F E ++M++L Sbjct: 260 EIPRDSLRLELKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEA---FLQEAQVMKKL 316 Query: 2239 RHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIH-RPNCQIDEKRRIKMALDVARGMNC 2415 RH +V V+ P + IV+EY+ +GSL + + + + MA +A GM Sbjct: 317 RHEKLVQLYAVVSEEP-IYIVTEYISKGSLLDFLKGEMGRYLRLPQLVDMAAQIASGM-- 373 Query: 2416 LHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAGTP-EWMAPEVL 2592 + VHRDL++ N+LV +N KV DFGL+RL +++ A P +W APE Sbjct: 374 AYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAA 433 Query: 2593 RNEQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVAS 2769 + K D++SFG++L EL T R P+ GM +V+ V + R+ P + + Sbjct: 434 LYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVE-RGYRMPCPPDCPESLHD 492 Query: 2770 IIRDCWQKDPNLRPSFIQLTSYLKTLQRLVIPSHQ 2874 ++ CW+KDP RP+F L ++L+ P +Q Sbjct: 493 LMFQCWRKDPEERPTFEYLQAFLEDYFTATEPQYQ 527
>O73798:IGF1R_XENLA Insulin-like growth factor 1 receptor precursor - Xenopus laevis| (African clawed frog) Length = 1358 Score = 130 bits (327), Expect = 4e-29 Identities = 86/279 (30%), Positives = 150/279 (53%), Gaps = 19/279 (6%) Frame = +1 Query: 2062 EILWEDLVIDERIGIGSYGEVYHADWNG-------TEVAVKKFLDQEFYGDALEEFRCEV 2220 E+ E + ++ +G GS+G VY G T+VA+K + + +E F E Sbjct: 989 EVPREKITMNRELGQGSFGMVYEGIAKGVVKDEAETKVAIKTVNEAASMRERIE-FLNEA 1047 Query: 2221 RIMRRLRHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIH--RPNCQIDE-------KR 2373 +M+ ++V +G V++ ++ E + RG L + RP+ + + K+ Sbjct: 1048 SVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPDTESNSGQPTPSLKK 1107 Query: 2374 RIKMALDVARGMNCLHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKS 2553 I+MA ++A GM+ L+ + VHRDL + N +V +++TVK+ DFG++R + T K Sbjct: 1108 MIQMAGEIADGMSYLNAN--KFVHRDLAARNCMVTEDFTVKIGDFGMTRDIYETDYYRKG 1165 Query: 2554 TAGT--PEWMAPEVLRNEQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQD 2724 G WM+PE L++ D++SFGV+LWE+ATL +P+ GM+ QV+ V + Sbjct: 1166 GKGLLPVRWMSPESLKDGVFTTNSDVWSFGVVLWEIATLAEQPYQGMSNEQVLRFV-MEG 1224 Query: 2725 RRLDIPKEVDPIVASIIRDCWQKDPNLRPSFIQLTSYLK 2841 L+ P ++ ++R CWQ +P +RPSF+++ S +K Sbjct: 1225 GLLEKPDNCPDMLFELMRMCWQFNPKMRPSFLEIISSIK 1263
>Q62662:FRK_RAT Tyrosine-protein kinase FRK - Rattus norvegicus (Rat)| Length = 506 Score = 130 bits (327), Expect = 4e-29 Identities = 87/268 (32%), Positives = 136/268 (50%), Gaps = 6/268 (2%) Frame = +1 Query: 2032 DLVLDEVSECEILWEDLVIDERIGIGSYGEVYHADWNGTEVAVKKFLDQEFYGDALEEFR 2211 DL V + EI + + +R+G G +GEV+ WN T K L +F Sbjct: 219 DLSYKTVDQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDP--NDFL 276 Query: 2212 CEVRIMRRLRHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPN-CQIDEKRRIKMA 2388 E +IM+ LRHP ++ T + I++E + GSL + + +I +++ MA Sbjct: 277 REAQIMKSLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDGGSKIRLTQQVDMA 336 Query: 2389 LDVARGMNCLHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRL---KHSTFLSSKSTA 2559 VA GM L + +HRDL + N+LV ++ KV DFGL+R+ + SK Sbjct: 337 AQVASGMAYLESQ--NYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESKHEI 394 Query: 2560 GTP-EWMAPEVLRNEQSNEKCDIYSFGVILWELATLRK-PWHGMNQMQVVGAVGFQDRRL 2733 P +W APE +R + + K D++SFG++L+E+ T K P+ GM QV+ +G Q+ RL Sbjct: 395 KLPVKWTAPEAIRTNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIHMLG-QNYRL 453 Query: 2734 DIPKEVDPIVASIIRDCWQKDPNLRPSF 2817 P SI+ +CW +P RP+F Sbjct: 454 PQPSNCPEQFYSIMMECWNVEPKQRPTF 481
>P05480:SRC_MOUSE Neuronal proto-oncogene tyrosine-protein kinase Src - Mus musculus| (Mouse) Length = 541 Score = 130 bits (326), Expect = 5e-29 Identities = 89/275 (32%), Positives = 144/275 (52%), Gaps = 4/275 (1%) Frame = +1 Query: 2062 EILWEDLVIDERIGIGSYGEVYHADWNGT-EVAVKKFLDQEFYGDALEEFRCEVRIMRRL 2238 EI E L ++ ++G G +GEV+ WNGT VA+K +A F E ++M++L Sbjct: 269 EIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEA---FLQEAQVMKKL 325 Query: 2239 RHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQ-IDEKRRIKMALDVARGMNC 2415 RH +V V+ P + IV+EY+ +GSL + + + + + M+ +A GM Sbjct: 326 RHEKLVQLYAVVSEEP-IYIVTEYMNKGSLLDFLKGETGKYLRLPQLVDMSAQIASGM-- 382 Query: 2416 LHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAGTP-EWMAPEVL 2592 + VHRDL++ N+LV +N KV DFGL+RL +++ A P +W APE Sbjct: 383 AYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAA 442 Query: 2593 RNEQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVAS 2769 + K D++SFG++L EL T R P+ GM +V+ V + R+ P E + Sbjct: 443 LYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVE-RGYRMPCPPECPESLHD 501 Query: 2770 IIRDCWQKDPNLRPSFIQLTSYLKTLQRLVIPSHQ 2874 ++ CW+K+P RP+F L ++L+ P +Q Sbjct: 502 LMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQ 536
>P54762:EPHB1_HUMAN Ephrin type-B receptor 1 precursor - Homo sapiens (Human)| Length = 984 Score = 130 bits (326), Expect = 5e-29 Identities = 84/266 (31%), Positives = 132/266 (49%), Gaps = 10/266 (3%) Frame = +1 Query: 2086 IDERIGIGSYGEVYHADWN---GTEVAVK-KFLDQEFYGDALEEFRCEVRIMRRLRHPNI 2253 I+E IG G +GEVY E+ V K L + +F E IM + HPNI Sbjct: 621 IEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRDFLSEASIMGQFDHPNI 680 Query: 2254 VLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGMNCLHTSVP 2433 + G VT+ + I++E++ G+L + + + Q + + M +A GM L + Sbjct: 681 IRLEGVVTKSRPVMIITEFMENGALDSFLRQNDGQFTVIQLVGMLRGIAAGMKYL--AEM 738 Query: 2434 TIVHRDLKSPNLLVDDNWTVKVCDFGLSR-----LKHSTFLSSKSTAGTPEWMAPEVLRN 2598 VHRDL + N+LV+ N KV DFGLSR T+ SS W APE + Sbjct: 739 NYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTAPEAIAY 798 Query: 2599 EQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVASII 2775 + D++S+G+++WE+ + +P+ M+ V+ A+ QD RL P + + ++ Sbjct: 799 RKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIE-QDYRLPPPMDCPAALHQLM 857 Query: 2776 RDCWQKDPNLRPSFIQLTSYLKTLQR 2853 DCWQKD N RP F ++ + L + R Sbjct: 858 LDCWQKDRNSRPRFAEIVNTLDKMIR 883
>Q60750:EPHA1_MOUSE Ephrin type-A receptor 1 precursor - Mus musculus (Mouse)| Length = 977 Score = 130 bits (326), Expect = 5e-29 Identities = 93/295 (31%), Positives = 146/295 (49%), Gaps = 9/295 (3%) Frame = +1 Query: 2041 LDEVSECEILWEDLVIDERIGIGSYGEVYHA-----DWNGTEVAVKKFLDQEFYGDALEE 2205 LD E + W L++D IG G +GEVY + VA+K D G Sbjct: 614 LDFAQELDPAW--LIVDTVIGEGEFGEVYRGALRLPSQDCKTVAIKTLKDTSPDGYWWNF 671 Query: 2206 FRCEVRIMRRLRHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKM 2385 R E IM + HP+I+ G +T+ + I++E++ G+L + Q+ + + M Sbjct: 672 LR-EATIMGQFNHPHILRLEGVITKRKPIMIITEFMENGALDAFLKEREDQLAPGQLVAM 730 Query: 2386 ALDVARGMNCLHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAGT 2565 L +A GMNCL S VHRDL + N+LV+ N KV DFGL+RL F + T G Sbjct: 731 LLGIASGMNCL--SGHNYVHRDLAARNILVNQNLCCKVSDFGLTRLL-DDFDGTYETQGG 787 Query: 2566 P---EWMAPEVLRNEQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRL 2733 W APE + + D++SFG+++WE+ + KP+ M+ +V+ ++ RL Sbjct: 788 KIPIRWTAPEAIAHRIFTTASDVWSFGIVMWEVLSFGDKPYGEMSNQEVMKSIE-DGYRL 846 Query: 2734 DIPKEVDPIVASIIRDCWQKDPNLRPSFIQLTSYLKTLQRLVIPSHQETASNHVP 2898 P + + ++++CW D RP F+QL ++L+ Q L P T +N P Sbjct: 847 PPPVDCPAPLYELMKNCWAYDRARRPHFLQLQAHLE--QLLTDPHSLRTIANFDP 899
>Q7TQP6:TNI3K_RAT Serine/threonine-protein kinase TNNI3K - Rattus norvegicus (Rat)| Length = 835 Score = 129 bits (325), Expect = 6e-29 Identities = 90/315 (28%), Positives = 151/315 (47%), Gaps = 26/315 (8%) Frame = +1 Query: 1975 RPRQNIECVSPSQVGSS-------------------KVDLVL---DEVSECEILWEDLVI 2088 RP++ + C SQ G K D++L + S + ++ Sbjct: 406 RPQEELPCNEYSQPGGDGSYVSVPSPLGKIKSMTKEKADVLLLRAELPSRFHLQLSEIEF 465 Query: 2089 DERIGIGSYGEVYHADWNGTEVAVKKFLDQEFYGDALEEFRC-EVRIMRRLRHPNIVLFM 2265 E IG GS+G+VY VA+K++ + + + C EV I+ +L HP +V F+ Sbjct: 466 HEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVVQFV 525 Query: 2266 GA-VTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGMNCLHTSVPTIV 2442 GA + P +IV++Y+ GSL+ ++H +D + ++ +A+DVA+GM LH+ I+ Sbjct: 526 GACLDDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIAVDVAKGMEYLHSLTQPII 585 Query: 2443 HRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKS-TAGTPEWMAPEVLRN-EQSNEK 2616 HRDL S N+L+ ++ V DFG SR S + + G WMAPEV + K Sbjct: 586 HRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNLRWMAPEVFTQCTRYTIK 645 Query: 2617 CDIYSFGVILWELATLRKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVASIIRDCWQKD 2796 D++S+ + LWEL T P+ + + + R I + ++S++ W Sbjct: 646 ADVFSYSLCLWELLTGEIPFAHLKPAAAAADMAYHHIRPPIGYSIPKPISSLLIRGWNAC 705 Query: 2797 PNLRPSFIQLTSYLK 2841 P RP F ++ S L+ Sbjct: 706 PEGRPEFSEVVSKLE 720
>P16092:FGFR1_MOUSE Basic fibroblast growth factor receptor 1 precursor - Mus musculus| (Mouse) Length = 822 Score = 129 bits (325), Expect = 6e-29 Identities = 107/339 (31%), Positives = 169/339 (49%), Gaps = 37/339 (10%) Frame = +1 Query: 1999 VSPSQVGSSKVDLVLDEVSECEI----LWE----DLVIDERIGIGSYGEVYHADWNG--- 2145 V PS++ SS + L VSE E+ WE LV+ + +G G +G+V A+ G Sbjct: 444 VRPSRLSSSGTPM-LAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDK 502 Query: 2146 ------TEVAVKKFLDQEFYGDALEEFRCEVRIMRRL-RHPNIVLFMGAVTRPPHLSIVS 2304 T+VAVK D L + E+ +M+ + +H NI+ +GA T+ L ++ Sbjct: 503 DKPNRVTKVAVKMLKSDATEKD-LSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIV 561 Query: 2305 EYLPRGSL---------------YKIIHRPNCQIDEKRRIKMALDVARGMNCLHTSVPTI 2439 EY +G+L Y H P Q+ K + A VARGM L + Sbjct: 562 EYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASK--KC 619 Query: 2440 VHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAGT--PEWMAPEVLRNEQSNE 2613 +HRDL + N+LV ++ +K+ DFGL+R H K+T G +WMAPE L + Sbjct: 620 IHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTH 679 Query: 2614 KCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVASIIRDCWQ 2790 + D++SFGV+LWE+ TL P+ G+ ++ + + R+D P + ++RDCW Sbjct: 680 QSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLK-EGHRMDKPSNCTNELYMMMRDCWH 738 Query: 2791 KDPNLRPSFIQLTSYLKTLQRLV-IPSHQETASNHVPYE 2904 P+ RP+F QL ++ L R+V + S+QE +P + Sbjct: 739 AVPSQRPTFKQL---VEDLDRIVALTSNQEYLDLSIPLD 774
>P29320:EPHA3_HUMAN Ephrin type-A receptor 3 precursor - Homo sapiens (Human)| Length = 983 Score = 129 bits (325), Expect = 6e-29 Identities = 86/267 (32%), Positives = 136/267 (50%), Gaps = 8/267 (2%) Frame = +1 Query: 2077 DLVIDERIGIGSYGEVYHADW---NGTEVAVK-KFLDQEFYGDALEEFRCEVRIMRRLRH 2244 ++ ID+ +G G +GEV + E++V K L + +F E IM + H Sbjct: 620 NISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRRDFLGEASIMGQFDH 679 Query: 2245 PNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGMNCLHT 2424 PNI+ G VT+ + IV+EY+ GSL + + + Q + + M +A GM L Sbjct: 680 PNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFTVIQLVGMLRGIASGMKYL-- 737 Query: 2425 SVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAGTP---EWMAPEVLR 2595 S VHRDL + N+L++ N KV DFGLSR+ ++ +T G W +PE + Sbjct: 738 SDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTSPEAIA 797 Query: 2596 NEQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVASI 2772 + D++S+G++LWE+ + +P+ M+ V+ AV + RL P + + + Sbjct: 798 YRKFTSASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVD-EGYRLPPPMDCPAALYQL 856 Query: 2773 IRDCWQKDPNLRPSFIQLTSYLKTLQR 2853 + DCWQKD N RP F Q+ S L L R Sbjct: 857 MLDCWQKDRNNRPKFEQIVSILDKLIR 883
>P00524:SRC_RSVSA Tyrosine-protein kinase transforming protein Src - Avian leukosis| virus RSA (RSV-SRA) (Rous sarcoma virus (strain Schmidt-Ruppin A)) Length = 526 Score = 129 bits (323), Expect = 1e-28 Identities = 88/263 (33%), Positives = 138/263 (52%), Gaps = 4/263 (1%) Frame = +1 Query: 2062 EILWEDLVIDERIGIGSYGEVYHADWNGT-EVAVKKFLDQEFYGDALEEFRCEVRIMRRL 2238 EI E L ++ ++G G +GEV+ WNGT VA+K +A F E ++M++L Sbjct: 261 EIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEA---FLQEAQVMKKL 317 Query: 2239 RHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIH-RPNCQIDEKRRIKMALDVARGMNC 2415 RH +V V+ P + IV+EY+ +GSL + + + + MA +A GM Sbjct: 318 RHEKLVQLYAVVSEEP-IYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGM-- 374 Query: 2416 LHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAGTP-EWMAPEVL 2592 + VHRDL++ N+LV +N KV DFGL+RL +++ A P +W APE Sbjct: 375 AYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAA 434 Query: 2593 RNEQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVAS 2769 + K D++SFG++L EL T R P+ GM +V+ V + R+ P E + Sbjct: 435 LYGRFTIKSDVWSFGILLTELTTKGRVPYPGMGNGEVLDRVE-RGYRMPCPPECPESLHD 493 Query: 2770 IIRDCWQKDPNLRPSFIQLTSYL 2838 ++ CW++DP RP+F L + L Sbjct: 494 LMCQCWRRDPEERPTFEYLQAQL 516
>Q9WUD9:SRC_RAT Proto-oncogene tyrosine-protein kinase Src - Rattus norvegicus (Rat)| Length = 536 Score = 129 bits (323), Expect = 1e-28 Identities = 87/264 (32%), Positives = 141/264 (53%), Gaps = 4/264 (1%) Frame = +1 Query: 2062 EILWEDLVIDERIGIGSYGEVYHADWNGT-EVAVKKFLDQEFYGDALEEFRCEVRIMRRL 2238 EI E L ++ ++G G +GEV+ WNGT VA+K +A F E ++M++L Sbjct: 264 EIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEA---FLQEAQVMKKL 320 Query: 2239 RHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQ-IDEKRRIKMALDVARGMNC 2415 RH +V V+ P + IV+EY+ +GSL + + + + + M+ +A GM Sbjct: 321 RHEKLVQLYAVVSEEP-IYIVTEYMNKGSLLDFLKGETGKYLRLPQLVDMSAQIASGM-- 377 Query: 2416 LHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAGTP-EWMAPEVL 2592 + VHRDL++ N+LV +N KV DFGL+RL +++ A P +W APE Sbjct: 378 AYVDRMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAA 437 Query: 2593 RNEQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVAS 2769 + K D++SFG++L EL T R P+ GM +V+ V + R+ P E + Sbjct: 438 LYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVE-RGYRMPCPPECPESLHD 496 Query: 2770 IIRDCWQKDPNLRPSFIQLTSYLK 2841 ++ CW+K+P RP+F L ++L+ Sbjct: 497 LMCQCWRKEPEERPTFEYLQAFLE 520
>P00525:SRC_AVISR Tyrosine-protein kinase transforming protein Src - Avian sarcoma| virus (strain rASV1441) Length = 526 Score = 129 bits (323), Expect = 1e-28 Identities = 88/263 (33%), Positives = 138/263 (52%), Gaps = 4/263 (1%) Frame = +1 Query: 2062 EILWEDLVIDERIGIGSYGEVYHADWNGT-EVAVKKFLDQEFYGDALEEFRCEVRIMRRL 2238 EI E L ++ ++G G +GEV+ WNGT VA+K +A F E ++M++L Sbjct: 261 EIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEA---FLQEAQVMKKL 317 Query: 2239 RHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIH-RPNCQIDEKRRIKMALDVARGMNC 2415 RH +V V+ P + IV+EY+ +GSL + + + + MA +A GM Sbjct: 318 RHEKLVQLYAVVSEEP-IYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGM-- 374 Query: 2416 LHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAGTP-EWMAPEVL 2592 + VHRDL++ N+LV +N KV DFGL+RL +++ A P +W APE Sbjct: 375 AYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAA 434 Query: 2593 RNEQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVAS 2769 + K D++SFG++L EL T R P+ GM +V+ V + R+ P E + Sbjct: 435 LYGRFTIKSDVWSFGILLTELTTKGRVPYPGMGNGEVLDRVE-RGYRMPCPPECPESLHD 493 Query: 2770 IIRDCWQKDPNLRPSFIQLTSYL 2838 ++ CW++DP RP+F L + L Sbjct: 494 LMCQCWRRDPEERPTFEYLQAQL 516
>P11362:FGFR1_HUMAN Basic fibroblast growth factor receptor 1 precursor - Homo sapiens| (Human) Length = 822 Score = 129 bits (323), Expect = 1e-28 Identities = 107/339 (31%), Positives = 169/339 (49%), Gaps = 37/339 (10%) Frame = +1 Query: 1999 VSPSQVGSSKVDLVLDEVSECEI----LWE----DLVIDERIGIGSYGEVYHADWNG--- 2145 V PS++ SS + L VSE E+ WE LV+ + +G G +G+V A+ G Sbjct: 444 VRPSRLSSSGTPM-LAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDK 502 Query: 2146 ------TEVAVKKFLDQEFYGDALEEFRCEVRIMRRL-RHPNIVLFMGAVTRPPHLSIVS 2304 T+VAVK D L + E+ +M+ + +H NI+ +GA T+ L ++ Sbjct: 503 DKPNRVTKVAVKMLKSDATEKD-LSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIV 561 Query: 2305 EYLPRGSL---------------YKIIHRPNCQIDEKRRIKMALDVARGMNCLHTSVPTI 2439 EY +G+L Y H P Q+ K + A VARGM L + Sbjct: 562 EYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASK--KC 619 Query: 2440 VHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAGT--PEWMAPEVLRNEQSNE 2613 +HRDL + N+LV ++ +K+ DFGL+R H K+T G +WMAPE L + Sbjct: 620 IHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTH 679 Query: 2614 KCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVASIIRDCWQ 2790 + D++SFGV+LWE+ TL P+ G+ ++ + + R+D P + ++RDCW Sbjct: 680 QSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLK-EGHRMDKPSNCTNELYMMMRDCWH 738 Query: 2791 KDPNLRPSFIQLTSYLKTLQRLV-IPSHQETASNHVPYE 2904 P+ RP+F QL ++ L R+V + S+QE +P + Sbjct: 739 AVPSQRPTFKQL---VEDLDRIVALTSNQEYLDLSMPLD 774
>P07947:YES_HUMAN Proto-oncogene tyrosine-protein kinase Yes - Homo sapiens (Human)| Length = 543 Score = 128 bits (322), Expect = 1e-28 Identities = 87/275 (31%), Positives = 146/275 (53%), Gaps = 4/275 (1%) Frame = +1 Query: 2062 EILWEDLVIDERIGIGSYGEVYHADWNGT-EVAVKKFLDQEFYGDALEEFRCEVRIMRRL 2238 EI E L ++ ++G G +GEV+ WNGT +VA+K +A F E +IM++L Sbjct: 271 EIPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEA---FLQEAQIMKKL 327 Query: 2239 RHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQ-IDEKRRIKMALDVARGMNC 2415 RH +V V+ P + IV+E++ +GSL + + + + + + MA +A GM Sbjct: 328 RHDKLVPLYAVVSEEP-IYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAY 386 Query: 2416 LHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAGTP-EWMAPEVL 2592 + +HRDL++ N+LV +N K+ DFGL+RL +++ A P +W APE Sbjct: 387 IERM--NYIHRDLRAANILVGENLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAA 444 Query: 2593 RNEQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVAS 2769 + K D++SFG++ EL T R P+ GM +V+ V + R+ P+ + Sbjct: 445 LYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVE-RGYRMPCPQGCPESLHE 503 Query: 2770 IIRDCWQKDPNLRPSFIQLTSYLKTLQRLVIPSHQ 2874 ++ CW+KDP+ RP+F + S+L+ P +Q Sbjct: 504 LMNLCWKKDPDERPTFEYIQSFLEDYFTATEPQYQ 538
>P63185:SRC_RSVSE Tyrosine-protein kinase transforming protein Src - Rous sarcoma virus| (strain Schmidt-Ruppin E) (RSV-SR-E) Length = 526 Score = 128 bits (322), Expect = 1e-28 Identities = 88/263 (33%), Positives = 137/263 (52%), Gaps = 4/263 (1%) Frame = +1 Query: 2062 EILWEDLVIDERIGIGSYGEVYHADWNGT-EVAVKKFLDQEFYGDALEEFRCEVRIMRRL 2238 EI E L ++ ++G G +GEV+ WNGT VA+K +A F E ++M++L Sbjct: 261 EIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEA---FLQEAQVMKKL 317 Query: 2239 RHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIH-RPNCQIDEKRRIKMALDVARGMNC 2415 RH +V V+ P + IV EY+ +GSL + + + + MA +A GM Sbjct: 318 RHKKLVQLYAVVSEEP-IYIVIEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGM-- 374 Query: 2416 LHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAGTP-EWMAPEVL 2592 + VHRDL++ N+LV +N KV DFGL+RL +++ A P +W APE Sbjct: 375 AYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAA 434 Query: 2593 RNEQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVAS 2769 + K D++SFG++L EL T R P+ GM +V+ V + R+ P E + Sbjct: 435 LYGRFTIKSDVWSFGILLTELTTKGRVPYPGMGNGEVLDRVE-RGYRMPCPPECPESLHD 493 Query: 2770 IIRDCWQKDPNLRPSFIQLTSYL 2838 ++ CW++DP RP+F L + L Sbjct: 494 LMSQCWRRDPEERPTFEYLQAQL 516
>P25020:SRC_RSVH1 Tyrosine-protein kinase transforming protein Src - Rous sarcoma virus| (strain H-19) Length = 526 Score = 128 bits (322), Expect = 1e-28 Identities = 89/263 (33%), Positives = 137/263 (52%), Gaps = 4/263 (1%) Frame = +1 Query: 2062 EILWEDLVIDERIGIGSYGEVYHADWNGT-EVAVKKFLDQEFYGDALEEFRCEVRIMRRL 2238 EI E L ++ ++G G +GEV+ WNGT VA+K +A F E ++M++L Sbjct: 261 EIPRESLRLEAKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEA---FLQEAQVMKKL 317 Query: 2239 RHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIH-RPNCQIDEKRRIKMALDVARGMNC 2415 RH +V V+ P + IV EY+ +GSL + + + + MA +A GM Sbjct: 318 RHEKLVQLYAVVSEEP-IYIVIEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGM-- 374 Query: 2416 LHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAGTP-EWMAPEVL 2592 + VHRDL++ N+LV +N KV DFGL+RL +++ A P +W APE Sbjct: 375 AYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAA 434 Query: 2593 RNEQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVAS 2769 + K D++SFG++L EL T R P+ GM +V+ V + R+ P E + Sbjct: 435 LYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVE-RAYRMPCPPECPESLHD 493 Query: 2770 IIRDCWQKDPNLRPSFIQLTSYL 2838 ++ CW+KDP RP+F L + L Sbjct: 494 LMCQCWRKDPEERPTFKYLQAQL 516
>P03949:ABL1_CAEEL Tyrosine-protein kinase abl-1 - Caenorhabditis elegans| Length = 1224 Score = 128 bits (322), Expect = 1e-28 Identities = 85/271 (31%), Positives = 138/271 (50%), Gaps = 7/271 (2%) Frame = +1 Query: 2056 ECEILWEDLVIDERIGIGSYGEVYHADWNGTE--VAVKKFLDQEFYGDALEEFRCEVRIM 2229 E E+ ++++ ++G G YG+VY W + +AVK + L EF E IM Sbjct: 303 EWELDRSEIIMHNKLGGGQYGDVYEGYWKRHDCTIAVKALKEDAM---PLHEFLAEAAIM 359 Query: 2230 RRLRHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQI-DEKRRIKMALDVARG 2406 + L H N+V +G T I++E++ G+L + + R + + ++MA +A G Sbjct: 360 KDLHHKNLVRLLGVCTHEAPFYIITEFMCNGNLLEYLRRTDKSLLPPIILVQMASQIASG 419 Query: 2407 MNCLHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSR-LKHSTFLSSKSTAGTPEWMAP 2583 M+ L +HRDL + N LV ++ VK+ DFGL+R +K T+ + +W AP Sbjct: 420 MSYLEAR--HFIHRDLAARNCLVSEHNIVKIADFGLARFMKEDTYTAHAGAKFPIKWTAP 477 Query: 2584 EVLRNEQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAV--GFQDRRLDIPKEVD 2754 E L + K D+++FGV+LWE+AT P+ G+ V G + GF R+D P+ Sbjct: 478 EGLAFNTFSSKSDVWAFGVLLWEIATYGMAPYPGVELSNVYGLLENGF---RMDGPQGCP 534 Query: 2755 PIVASIIRDCWQKDPNLRPSFIQLTSYLKTL 2847 P V ++ CW P+ RP F + L+ L Sbjct: 535 PSVYRLMLQCWNWSPSDRPRFRDIHFNLENL 565
>Q04736:YES_MOUSE Proto-oncogene tyrosine-protein kinase Yes - Mus musculus (Mouse)| Length = 541 Score = 128 bits (321), Expect = 2e-28 Identities = 87/275 (31%), Positives = 146/275 (53%), Gaps = 4/275 (1%) Frame = +1 Query: 2062 EILWEDLVIDERIGIGSYGEVYHADWNGT-EVAVKKFLDQEFYGDALEEFRCEVRIMRRL 2238 EI E L ++ ++G G +GEV+ WNGT +VA+K +A F E +IM++L Sbjct: 269 EIPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEA---FLQEAQIMKKL 325 Query: 2239 RHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQ-IDEKRRIKMALDVARGMNC 2415 RH +V V+ P + IV+E++ +GSL + + + + + + MA +A GM Sbjct: 326 RHDKLVPLYAVVSEEP-IYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAY 384 Query: 2416 LHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAGTP-EWMAPEVL 2592 + +HRDL++ N+LV +N K+ DFGL+RL +++ A P +W APE Sbjct: 385 IERM--NYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAA 442 Query: 2593 RNEQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVAS 2769 + K D++SFG++ EL T R P+ GM +V+ V + R+ P+ + Sbjct: 443 LYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVE-RGYRMPCPQGCPESLHE 501 Query: 2770 IIRDCWQKDPNLRPSFIQLTSYLKTLQRLVIPSHQ 2874 ++ CW+KDP+ RP+F + S+L+ P +Q Sbjct: 502 LMNLCWKKDPDERPTFEYIQSFLEDYFTATEPQYQ 536
>Q60751:IGF1R_MOUSE Insulin-like growth factor 1 receptor precursor - Mus musculus| (Mouse) Length = 1373 Score = 128 bits (321), Expect = 2e-28 Identities = 87/296 (29%), Positives = 151/296 (51%), Gaps = 20/296 (6%) Frame = +1 Query: 2056 ECEILWEDLVIDERIGIGSYGEVYHADWNG-------TEVAVKKFLDQEFYGDALEEFRC 2214 E E+ E + ++ +G GS+G VY G T VA+K + + +E F Sbjct: 992 EWEVAREKITMNRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIE-FLN 1050 Query: 2215 EVRIMRRLRHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEK-------- 2370 E +M+ ++V +G V++ ++ E + RG L + ++++ Sbjct: 1051 EASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEVEQNNLVLIPPS 1110 Query: 2371 --RRIKMALDVARGMNCLHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLS 2544 + I+MA ++A GM L+ + VHRDL + N +V +++TVK+ DFG++R + T Sbjct: 1111 LSKMIQMAGEIADGMAYLNAN--KFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYY 1168 Query: 2545 SKSTAGT--PEWMAPEVLRNEQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVG 2715 K G WM+PE L++ D++SFGV+LWE+ATL +P+ G++ QV+ V Sbjct: 1169 RKGGKGLLPVRWMSPESLKDGVFTTHSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFV- 1227 Query: 2716 FQDRRLDIPKEVDPIVASIIRDCWQKDPNLRPSFIQLTSYLKTLQRLVIPSHQETA 2883 + LD P ++ ++R CWQ +P +RPSF+++ +K PS QE + Sbjct: 1228 MEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIIGSIKDEME---PSFQEVS 1280
>Q07494:EPHB1_CHICK Ephrin type-B receptor 1 - Gallus gallus (Chicken)| Length = 984 Score = 128 bits (321), Expect = 2e-28 Identities = 83/266 (31%), Positives = 131/266 (49%), Gaps = 10/266 (3%) Frame = +1 Query: 2086 IDERIGIGSYGEVYHADWN---GTEVAVK-KFLDQEFYGDALEEFRCEVRIMRRLRHPNI 2253 I+E IG G +GEVY E+ V K L + +F E IM + HPNI Sbjct: 621 IEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRDFLSEASIMGQFDHPNI 680 Query: 2254 VLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGMNCLHTSVP 2433 + G VT+ + I++E++ G+L + + + Q + + M +A GM L + Sbjct: 681 IRLEGVVTKSRPVMIITEFMENGALDSFLRQNDGQFTVIQLVGMLRGIAAGMKYL--AEM 738 Query: 2434 TIVHRDLKSPNLLVDDNWTVKVCDFGLSR-----LKHSTFLSSKSTAGTPEWMAPEVLRN 2598 VHRDL + N+LV+ N KV DFGLSR T+ SS W APE + Sbjct: 739 NYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTAPEAIAY 798 Query: 2599 EQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVASII 2775 + D++S+G+++WE+ + +P+ M+ V+ A+ QD RL P + + ++ Sbjct: 799 RKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIE-QDYRLPPPMDCPAALHQLM 857 Query: 2776 RDCWQKDPNLRPSFIQLTSYLKTLQR 2853 DCWQKD N RP ++ + L + R Sbjct: 858 LDCWQKDRNTRPRLAEIVNTLDKMIR 883
>P29319:EPHA3_MOUSE Ephrin type-A receptor 3 precursor - Mus musculus (Mouse)| Length = 983 Score = 128 bits (321), Expect = 2e-28 Identities = 86/267 (32%), Positives = 135/267 (50%), Gaps = 8/267 (2%) Frame = +1 Query: 2077 DLVIDERIGIGSYGEVYHADW---NGTEVAVK-KFLDQEFYGDALEEFRCEVRIMRRLRH 2244 ++ ID+ +G G +GEV + E++V K L + +F E IM + H Sbjct: 620 NISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRRDFLGEASIMGQFDH 679 Query: 2245 PNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGMNCLHT 2424 PNI+ G VT+ IV+EY+ GSL + + + Q + + M +A GM L Sbjct: 680 PNIIRLEGVVTKSKPEMIVTEYMENGSLDSFLRKHDAQFTVIQLVGMLRGIASGMKYL-- 737 Query: 2425 SVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAGTP---EWMAPEVLR 2595 S VHRDL + N+L++ N KV DFGLSR+ ++ +T G W +PE + Sbjct: 738 SDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTSPEAMS 797 Query: 2596 NEQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVASI 2772 + D++S+G++LWE+ + +P+ M+ V+ AV + RL P + + + Sbjct: 798 YRKFTSASDVWSYGIVLWEVMSYGERPYSQMSNQDVIKAVD-ERYRLPPPMDCPAALYQL 856 Query: 2773 IRDCWQKDPNLRPSFIQLTSYLKTLQR 2853 + DCWQKD N RP F Q+ S L L R Sbjct: 857 MLDCWQKDRNNRPKFEQIVSILDKLIR 883
>P24062:IGF1R_RAT Insulin-like growth factor 1 receptor precursor - Rattus norvegicus| (Rat) Length = 1370 Score = 127 bits (320), Expect = 2e-28 Identities = 87/295 (29%), Positives = 150/295 (50%), Gaps = 19/295 (6%) Frame = +1 Query: 2056 ECEILWEDLVIDERIGIGSYGEVYHADWNG-------TEVAVKKFLDQEFYGDALEEFRC 2214 E E+ E + ++ +G GS+G VY G T VA+K + + +E F Sbjct: 992 EWEVAREKITMNRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIE-FLN 1050 Query: 2215 EVRIMRRLRHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEK-------- 2370 E +M+ ++V +G V++ ++ E + RG L + +++ Sbjct: 1051 EASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEVENNLVLIPPSL 1110 Query: 2371 -RRIKMALDVARGMNCLHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSS 2547 + I+MA ++A GM L+ + VHRDL + N +V +++TVK+ DFG++R + T Sbjct: 1111 SKMIQMAGEIADGMAYLNAN--KFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYR 1168 Query: 2548 KSTAGT--PEWMAPEVLRNEQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGF 2718 K G WM+PE L++ D++SFGV+LWE+ATL +P+ G++ QV+ V Sbjct: 1169 KGGKGLLPVRWMSPESLKDGVFTTHSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFV-M 1227 Query: 2719 QDRRLDIPKEVDPIVASIIRDCWQKDPNLRPSFIQLTSYLKTLQRLVIPSHQETA 2883 + LD P ++ ++R CWQ +P +RPSF+++ +K PS QE + Sbjct: 1228 EGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIIGSIKDEME---PSFQEVS 1279
>Q91571:EPB1A_XENLA Ephrin type-B receptor 1-A precursor - Xenopus laevis (African clawed| frog) Length = 985 Score = 127 bits (320), Expect = 2e-28 Identities = 83/266 (31%), Positives = 133/266 (50%), Gaps = 10/266 (3%) Frame = +1 Query: 2086 IDERIGIGSYGEVYHADW---NGTEVAVK-KFLDQEFYGDALEEFRCEVRIMRRLRHPNI 2253 I+E IG G +GEVY + E++V K L + +F E IM + HPNI Sbjct: 622 IEEVIGAGEFGEVYKGRLKLPSKREISVAIKTLKAGYSEKQRRDFLSEASIMGQFDHPNI 681 Query: 2254 VLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGMNCLHTSVP 2433 + G VT+ + I++E++ G+L + + + Q + + M +A GM L S Sbjct: 682 IRLEGVVTKSRPVMIITEFMENGALDSFLRQNDGQFTVIQLVGMLRGIAAGMKYL--SEM 739 Query: 2434 TIVHRDLKSPNLLVDDNWTVKVCDFGLSR-----LKHSTFLSSKSTAGTPEWMAPEVLRN 2598 VHRDL + N+LV+ N KV DFGLSR T+ SS W A E + Sbjct: 740 NYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTAQEAIAY 799 Query: 2599 EQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVASII 2775 + D++S+G+++WE+ + +P+ M+ V+ A+ QD RL P + + ++ Sbjct: 800 RKFTSASDVWSYGIVMWEVMSYGERPYWTMSNQDVINAIE-QDYRLPPPMDCPAALHQLM 858 Query: 2776 RDCWQKDPNLRPSFIQLTSYLKTLQR 2853 DCWQKD N RP ++ + L+ + R Sbjct: 859 LDCWQKDRNSRPRLAEIVNTLRPMIR 884
>Q28923:YES_CANFA Proto-oncogene tyrosine-protein kinase Yes - Canis familiaris (Dog)| Length = 539 Score = 127 bits (319), Expect = 3e-28 Identities = 87/275 (31%), Positives = 146/275 (53%), Gaps = 4/275 (1%) Frame = +1 Query: 2062 EILWEDLVIDERIGIGSYGEVYHADWNGT-EVAVKKFLDQEFYGDALEEFRCEVRIMRRL 2238 EI E L ++ ++G G +GEV+ WNGT +VA+K +A F E +IM++L Sbjct: 267 EIPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKLGTMMPEA---FLQEAQIMKKL 323 Query: 2239 RHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQ-IDEKRRIKMALDVARGMNC 2415 RH +V V+ P + IV+E++ +GSL + + + + + + MA +A GM Sbjct: 324 RHDKLVPLYAVVSEEP-IYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAY 382 Query: 2416 LHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAGTP-EWMAPEVL 2592 + +HRDL++ N+LV +N K+ DFGL+RL +++ A P +W APE Sbjct: 383 IERM--NYIHRDLRAANILVGENLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAA 440 Query: 2593 RNEQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVAS 2769 + K D++SFG++ EL T R P+ GM +V+ V + R+ P+ + Sbjct: 441 LYGRFTIKSDVWSFGILQTELTTKGRVPYPGMVNREVLEQVE-RGYRMPCPQGCPESLHE 499 Query: 2770 IIRDCWQKDPNLRPSFIQLTSYLKTLQRLVIPSHQ 2874 ++ CW+KDP+ RP+F + S+L+ P +Q Sbjct: 500 LMNLCWKKDPDERPTFEYIQSFLEDYFTAAEPQYQ 534
>P42688:SRK2_SPOLA Tyrosine-protein kinase SRK2 - Spongilla lacustris (Freshwater| sponge) Length = 362 Score = 127 bits (319), Expect = 3e-28 Identities = 91/289 (31%), Positives = 144/289 (49%), Gaps = 3/289 (1%) Frame = +1 Query: 2026 KVDLVLDEVSECEILWEDLVIDERIGIGSYGEVYHADWNG-TEVAVKKFLDQEFYGDALE 2202 ++DL EI + + + ++G G +GEVY WN T VAVK A Sbjct: 77 QIDLSHKTKDMWEISRDSITLIRKLGAGQFGEVYQGLWNNSTPVAVKTLKAGTMQPAA-- 134 Query: 2203 EFRCEVRIMRRLRHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIK 2382 F E +IM++LRHP ++ T+ + I++E + +GSL + + + I Sbjct: 135 -FLAEAQIMKKLRHPKLIQLYAVCTQGEPVYIITELMSKGSLLDYLQGEAGALKLPQLID 193 Query: 2383 MALDVARGMNCLHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAG 2562 MA VA GM + + +HRDL + N+LV DN KV DFGL+RL S ++ A Sbjct: 194 MAAQVAAGM--AYLELHNYIHRDLAARNILVGDNNICKVADFGLARLIVSDDYNATEGAK 251 Query: 2563 TP-EWMAPEVLRNEQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLD 2736 P +W APE + + K D++SFG+++ EL T R P+ GM+ +V+ + + R+ Sbjct: 252 FPIKWTAPEAALFNRFSIKSDVWSFGILITELVTYGRIPYPGMSNAEVLQNLD-KGYRMP 310 Query: 2737 IPKEVDPIVASIIRDCWQKDPNLRPSFIQLTSYLKTLQRLVIPSHQETA 2883 P + I+ DCW+++P RP+F L L+ L +Q A Sbjct: 311 CPVTTPESLYQIMLDCWKRNPADRPTFEALQWRLEDFFVLDAGQYQHAA 359
>P31693:SRC_RSVPA Tyrosine-protein kinase transforming protein Src - Rous sarcoma virus| (strain PA101T) Length = 523 Score = 127 bits (319), Expect = 3e-28 Identities = 89/263 (33%), Positives = 138/263 (52%), Gaps = 4/263 (1%) Frame = +1 Query: 2062 EILWEDLVIDERIGIGSYGEVYHADWNGT-EVAVKKFLDQEFYGDALEEFRCEVRIMRRL 2238 EI E L ++ ++G G +GEV+ WNGT VA+K +A F E ++M++L Sbjct: 258 EIPRESLRLEVKLGQGYFGEVWMGTWNGTTRVAIKTLKPGTMSPEA---FLQEAQVMKKL 314 Query: 2239 RHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIH-RPNCQIDEKRRIKMALDVARGMNC 2415 RH +V V+ P + IV EY+ +GSL + + + ++MA +A GM Sbjct: 315 RHEKLVQLYAMVSEEP-IYIVIEYMSKGSLLDFLKGEMGKYLRLPQLVEMAAQIASGM-- 371 Query: 2416 LHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAGTP-EWMAPEVL 2592 + VHRDL++ N+LV +N KV DFGL+RL +++ A P +W APE Sbjct: 372 AYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARPGARFPVKWTAPEAA 431 Query: 2593 RNEQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVAS 2769 + K D++SFG++L EL T R P+ GM +V+ V + R+ P E + Sbjct: 432 LYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNGEVLDRVE-RGYRMPCPPECPESLHD 490 Query: 2770 IIRDCWQKDPNLRPSFIQLTSYL 2838 ++ CW+KDP RP+F L + L Sbjct: 491 LMCQCWRKDPEERPTFEYLQAQL 513
>Q8QFP8:LIMK1_CHICK LIM domain kinase 1 - Gallus gallus (Chicken)| Length = 662 Score = 127 bits (319), Expect = 3e-28 Identities = 94/282 (33%), Positives = 137/282 (48%), Gaps = 24/282 (8%) Frame = +1 Query: 2077 DLVIDERIGIGSYGEVYHADWNGT-EVAVKKFLDQEFYGDALEEFRCEVRIMRRLRHPNI 2253 DL+ E +G G +G+ T EV V K L + F + F EV++MR L HPN+ Sbjct: 345 DLIHGEVLGKGCFGQAIKVTHRETGEVMVMKELIR-FDEETQRTFLKEVKVMRCLEHPNV 403 Query: 2254 VLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGMNCLHTSVP 2433 + F+G + + L+ ++EY+ G+L +I + +R+ A D+A GM LH+ Sbjct: 404 LKFIGVLYKEKRLNFITEYIKGGTLRGLIKSMDSHYPWSQRVSFAKDIAAGMAYLHSM-- 461 Query: 2434 TIVHRDLKSPNLLVDDNWTVKVCDFGLSRL--------KHSTFLSSK------STAGTPE 2571 I+HRDL S N LV +N +V V DFGL+RL +H L + G P Sbjct: 462 NIIHRDLNSHNCLVRENKSVVVADFGLARLMVDEKNQPEHLQNLKKPDRKKRYTVVGNPY 521 Query: 2572 WMAPEVLRNEQSNEKCDIYSFGVILWELA---------TLRKPWHGMNQMQVVGAVGFQD 2724 WMAPE++ +EK DI+SFG++L E+ R G+N GF + Sbjct: 522 WMAPEMINGRSYDEKVDIFSFGIVLCEIIGRVSADPDYLPRTTDFGLN------VRGFLE 575 Query: 2725 RRLDIPKEVDPIVASIIRDCWQKDPNLRPSFIQLTSYLKTLQ 2850 R P P I C DP RPSF +L +L+TL+ Sbjct: 576 RY--CPPACPPSFFPIAACCCDLDPEKRPSFSKLEQWLETLR 615
>P00530:FPS_FUJSV Tyrosine-protein kinase transforming protein FPS - Fujinami sarcoma| virus Length = 873 Score = 127 bits (319), Expect = 3e-28 Identities = 83/253 (32%), Positives = 135/253 (53%), Gaps = 5/253 (1%) Frame = +1 Query: 2074 EDLVIDERIGIGSYGEVYHADW--NGTEVAVKKFLDQEFYGDALEEFRCEVRIMRRLRHP 2247 ED+++ ERIG G++GEV+ + T VAVK + + +F E RI+++ HP Sbjct: 610 EDVLLGERIGRGNFGEVFSGRLRADNTPVAVKS-CRETLPPELKAKFLQEARILKQCNHP 668 Query: 2248 NIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGMNCLHTS 2427 NIV +G T+ + IV E + G + ++ K+ IKM + A GM L + Sbjct: 669 NIVRLIGVCTQKQPIYIVMELVQGGDFLSFLRSKGPRLKMKKLIKMMENAAAGMEYLESK 728 Query: 2428 VPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKH-STFLSSKSTAGTP-EWMAPEVLRNE 2601 +HRDL + N LV + T+K+ DFG+SR + + S+ P +W APE L Sbjct: 729 --HCIHRDLAARNCLVTEKNTLKISDFGMSRQEEDGVYASTGGMKQIPVKWTAPEALNYG 786 Query: 2602 QSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVASIIR 2778 + + D++SFG++LWE +L P+ ++ Q A+ Q RL+ P++ V +++ Sbjct: 787 WYSSESDVWSFGILLWEAFSLGAVPYANLSNQQTREAIE-QGVRLEPPEQCPEDVYRLMQ 845 Query: 2779 DCWQKDPNLRPSF 2817 CW+ DP+ RPSF Sbjct: 846 RCWEYDPHRRPSF 858
>P29318:EPHA3_CHICK Ephrin type-A receptor 3 precursor - Gallus gallus (Chicken)| Length = 983 Score = 127 bits (319), Expect = 3e-28 Identities = 86/267 (32%), Positives = 135/267 (50%), Gaps = 8/267 (2%) Frame = +1 Query: 2077 DLVIDERIGIGSYGEVYHADW---NGTEVAVK-KFLDQEFYGDALEEFRCEVRIMRRLRH 2244 ++ ID+ +G G +GEV + E++V K L + +F E IM + H Sbjct: 620 NISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKAGYTEKQRRDFLGEASIMGQFDH 679 Query: 2245 PNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGMNCLHT 2424 PNI+ G VT+ + IV+EY+ GSL + + + Q + + M +A GM L Sbjct: 680 PNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFTVIQLVGMLRGIASGMKYL-- 737 Query: 2425 SVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAGTP---EWMAPEVLR 2595 S VHRDL + N+L++ N KV DFGLSR+ ++ +T G W +PE + Sbjct: 738 SDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTSPEAIA 797 Query: 2596 NEQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVASI 2772 + D +S+G++LWE+ + +P+ M+ V+ AV + RL P + + + Sbjct: 798 YRKFTSASDAWSYGIVLWEVMSYGERPYWEMSFQDVIKAVD-EGYRLPPPMDCPAALYQL 856 Query: 2773 IRDCWQKDPNLRPSFIQLTSYLKTLQR 2853 + DCWQKD N RP F Q+ S L L R Sbjct: 857 MLDCWQKDRNNRPKFEQIVSILDKLIR 883
>Q3SZJ2:RIPK2_BOVIN Receptor-interacting serine/threonine-protein kinase 2 - Bos taurus| (Bovine) Length = 540 Score = 127 bits (318), Expect = 4e-28 Identities = 91/288 (31%), Positives = 150/288 (52%), Gaps = 28/288 (9%) Frame = +1 Query: 2077 DLVIDERIGIGSYGEVYHADWNGTEVAVKKF------LDQEFYGDALEEFRCEVRIMRRL 2238 DL R G+ HADW +VAVK LD E D L E I+ + Sbjct: 20 DLRYLSRGASGTVSSARHADWR-VQVAVKHLHIHSPLLDSE-RNDVLRE----AEILHKA 73 Query: 2239 RHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRP--NCQIDEKRRIKMALDVARGMN 2412 R I+ +G P L IV+EY+P GSL +++HR + R ++ ++A G+N Sbjct: 74 RFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKIEYPDVPWPLRFRILHEIALGVN 133 Query: 2413 CLHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAGTPE-----WM 2577 LH P ++H DLK+ N+L+D+ + VK+ DFGLS+ + + S+S+ PE +M Sbjct: 134 YLHNMNPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIVYM 193 Query: 2578 APEVL---RNEQSNEKCDIYSFGVILWELATLRKPWHGM-NQMQVVGAVGFQDRRLDIPK 2745 PE + +++ K DIYS+ +I+WE+ + ++P+ + N +Q++ +V Q R D + Sbjct: 194 PPENYEPGQKARASVKHDIYSYAIIIWEVLSRKQPFEDVTNPLQIMYSVS-QGHRPDTNE 252 Query: 2746 EVDP-------IVASIIRDCWQKDPNLRPSF----IQLTSYLKTLQRL 2856 E P ++ S+I W ++P+ RPSF I+L L+T + + Sbjct: 253 ESLPFDIPHRALMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEI 300
>P42683:LCK_CHICK Proto-oncogene tyrosine-protein kinase LCK - Gallus gallus (Chicken)| Length = 508 Score = 127 bits (318), Expect = 4e-28 Identities = 81/266 (30%), Positives = 138/266 (51%), Gaps = 4/266 (1%) Frame = +1 Query: 2056 ECEILWEDLVIDERIGIGSYGEVYHADWNG-TEVAVKKFLDQEFYGDALEEFRCEVRIMR 2232 E E+ E L + E++G G +GEV+ +NG T+VA+K A F E +M+ Sbjct: 236 EWEVPRESLKLVEKLGAGQFGEVWMGFYNGHTKVAIKNLKQGSMSPSA---FLAEANLMK 292 Query: 2233 RLRHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPN-CQIDEKRRIKMALDVARGM 2409 L+HP +V VT+ P + I++EY+ +GSL + ++ + + MA +A GM Sbjct: 293 NLQHPRLVRLYAVVTKEP-IYIITEYMEKGSLVDFLKTSEGIKLSINKLLDMAAQIAEGM 351 Query: 2410 NCLHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAGTP-EWMAPE 2586 + +HRDL++ N+LV + K+ DFGL+RL +++ A P +W APE Sbjct: 352 AFIEAK--NYIHRDLRAANILVSEALCCKIADFGLARLIEDNEYTAREGAKFPIKWTAPE 409 Query: 2587 VLRNEQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIV 2763 + K D++SFG++L E+ T R P+ GM +V+ + + R+ P + Sbjct: 410 AINYGTFTIKSDVWSFGILLTEIVTYGRIPYPGMTNPEVIQNLE-RGYRMPQPDNCPQEL 468 Query: 2764 ASIIRDCWQKDPNLRPSFIQLTSYLK 2841 ++ CW++ P RP+F + S L+ Sbjct: 469 YELMMQCWKEQPEERPTFEYMKSVLE 494
>P08069:IGF1R_HUMAN Insulin-like growth factor 1 receptor precursor - Homo sapiens| (Human) Length = 1367 Score = 127 bits (318), Expect = 4e-28 Identities = 86/281 (30%), Positives = 146/281 (51%), Gaps = 19/281 (6%) Frame = +1 Query: 2056 ECEILWEDLVIDERIGIGSYGEVYHADWNG-------TEVAVKKFLDQEFYGDALEEFRC 2214 E E+ E + + +G GS+G VY G T VA+K + + +E F Sbjct: 991 EWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIE-FLN 1049 Query: 2215 EVRIMRRLRHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIH--RPNCQIDE------- 2367 E +M+ ++V +G V++ ++ E + RG L + RP + + Sbjct: 1050 EASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSL 1109 Query: 2368 KRRIKMALDVARGMNCLHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSS 2547 + I+MA ++A GM L+ + VHRDL + N +V +++TVK+ DFG++R + T Sbjct: 1110 SKMIQMAGEIADGMAYLNAN--KFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYR 1167 Query: 2548 KSTAGT--PEWMAPEVLRNEQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGF 2718 K G WM+PE L++ D++SFGV+LWE+ATL +P+ G++ QV+ V Sbjct: 1168 KGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFV-M 1226 Query: 2719 QDRRLDIPKEVDPIVASIIRDCWQKDPNLRPSFIQLTSYLK 2841 + LD P ++ ++R CWQ +P +RPSF+++ S +K Sbjct: 1227 EGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIK 1267
>Q05688:IGF1R_BOVIN Insulin-like growth factor 1 receptor precursor - Bos taurus (Bovine)| Length = 640 Score = 127 bits (318), Expect = 4e-28 Identities = 86/281 (30%), Positives = 146/281 (51%), Gaps = 19/281 (6%) Frame = +1 Query: 2056 ECEILWEDLVIDERIGIGSYGEVYHADWNG-------TEVAVKKFLDQEFYGDALEEFRC 2214 E E+ E + + +G GS+G VY G T VA+K + + +E F Sbjct: 264 EWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIE-FLN 322 Query: 2215 EVRIMRRLRHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIH--RPNCQIDE------- 2367 E +M+ ++V +G V++ ++ E + RG L + RP + + Sbjct: 323 EASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSL 382 Query: 2368 KRRIKMALDVARGMNCLHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSS 2547 + I+MA ++A GM L+ + VHRDL + N +V +++TVK+ DFG++R + T Sbjct: 383 SKMIQMAGEIADGMAYLNAN--KFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYR 440 Query: 2548 KSTAGT--PEWMAPEVLRNEQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGF 2718 K G WM+PE L++ D++SFGV+LWE+ATL +P+ G++ QV+ V Sbjct: 441 KGGKGLLPVRWMSPESLKDGVFTTHSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFV-M 499 Query: 2719 QDRRLDIPKEVDPIVASIIRDCWQKDPNLRPSFIQLTSYLK 2841 + LD P ++ ++R CWQ +P +RPSF+++ S +K Sbjct: 500 EGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSVK 540
>P00541:FPS_AVISP Tyrosine-protein kinase transforming protein Fps - Avian sarcoma| virus (strain PRCII) Length = 533 Score = 127 bits (318), Expect = 4e-28 Identities = 83/253 (32%), Positives = 133/253 (52%), Gaps = 5/253 (1%) Frame = +1 Query: 2074 EDLVIDERIGIGSYGEVYHADW--NGTEVAVKKFLDQEFYGDALEEFRCEVRIMRRLRHP 2247 ED+++ ERIG G++GEV+ + T VAVK + + +F E RI+++ HP Sbjct: 270 EDVLLGERIGRGNFGEVFSGRLRADNTPVAVKS-CRETLPPELKAKFLQEARILKQYNHP 328 Query: 2248 NIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGMNCLHTS 2427 NIV +G T+ + IV E + G + + K IKM + A GM L + Sbjct: 329 NIVRLIGVCTQKQPIYIVMELVQGGDFLSFLRSKGPHLKMKELIKMMENAAAGMEYLESK 388 Query: 2428 VPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKH-STFLSSKSTAGTP-EWMAPEVLRNE 2601 +HRDL + N LV + T+K+ DFG+SR + + S+ P +W APE L Sbjct: 389 --HCIHRDLAARNCLVTEKNTLKISDFGMSRQEEDGVYASTGGMKQIPVKWTAPEALNYG 446 Query: 2602 QSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVASIIR 2778 + + + D++SFG++LWE +L P+ ++ Q A+ Q RL+ P++ V +++ Sbjct: 447 RYSSESDVWSFGILLWEAFSLGAVPYANLSNQQTREAIE-QGVRLEPPEQCPEDVYRLMQ 505 Query: 2779 DCWQKDPNLRPSF 2817 CW+ DP RPSF Sbjct: 506 RCWEYDPRRRPSF 518
>Q04589:FGFR1_RAT Basic fibroblast growth factor receptor 1 precursor - Rattus| norvegicus (Rat) Length = 822 Score = 127 bits (318), Expect = 4e-28 Identities = 105/338 (31%), Positives = 167/338 (49%), Gaps = 36/338 (10%) Frame = +1 Query: 1999 VSPSQVGSSKVDLVLDEVSECEI----LWE----DLVIDERIGIGSYGEVYHADWNG--- 2145 V PS++ SS + L VSE E+ WE LV+ + +G G +G+V A+ G Sbjct: 444 VRPSRLSSSGTPM-LAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDK 502 Query: 2146 ------TEVAVKKFLDQEFYGDALEEFRCEVRIMRRL-RHPNIVLFMGAVTRPPHLSIVS 2304 T+VAVK D L + E+ +M+ + +H NI+ +GA T+ L ++ Sbjct: 503 DKPNRVTKVAVKMLKSDATEKD-LSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIV 561 Query: 2305 EYLPRGSL---------------YKIIHRPNCQIDEKRRIKMALDVARGMNCLHTSVPTI 2439 EY +G+L Y H P Q+ K + A VARGM L + Sbjct: 562 EYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASK--KC 619 Query: 2440 VHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAGT--PEWMAPEVLRNEQSNE 2613 +HRDL + N+LV ++ +K+ DFGL+R H K+T G +WMAPE L + Sbjct: 620 IHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTH 679 Query: 2614 KCDIYSFGVILWELATLRKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVASIIRDCWQK 2793 + D++SFGV+LWE+ TL + ++ + + + R+D P + ++RDCW Sbjct: 680 QSDVWSFGVLLWEIFTLGGSPNPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWNA 739 Query: 2794 DPNLRPSFIQLTSYLKTLQRLV-IPSHQETASNHVPYE 2904 P+ RP+F QL ++ L R+V + S+QE +P + Sbjct: 740 VPSQRPTFKQL---VEDLDRIVALTSNQEYLDLSMPLD 774
>P54761:EPHB4_MOUSE Ephrin type-B receptor 4 precursor - Mus musculus (Mouse)| Length = 987 Score = 127 bits (318), Expect = 4e-28 Identities = 85/266 (31%), Positives = 128/266 (48%), Gaps = 10/266 (3%) Frame = +1 Query: 2086 IDERIGIGSYGEVYH----ADWNGTEVAVKKFLDQEFYGDALEEFRCEVRIMRRLRHPNI 2253 I+E IG G +GEV A K L + EF E IM + HPNI Sbjct: 617 IEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTERQRREFLSEASIMGQFEHPNI 676 Query: 2254 VLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGMNCLHTSVP 2433 + G VT + I++E++ G+L + + Q + + M +A GM L + Sbjct: 677 IRLEGVVTNSVPVMILTEFMENGALDSFLRLNDGQFTVIQLVGMLRGIASGMRYL--AEM 734 Query: 2434 TIVHRDLKSPNLLVDDNWTVKVCDFGLSRL-----KHSTFLSSKSTAGTPEWMAPEVLRN 2598 + VHRDL + N+LV+ N KV DFGLSR T+ SS + W APE + Sbjct: 735 SYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTYTSSLGGKISIRWTAPEAIAF 794 Query: 2599 EQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVASII 2775 + D +S+G+++WE+ + +P+ M+ V+ A+ QD RL P + + ++ Sbjct: 795 RKFTSASDAWSYGIVMWEVMSFGERPYWDMSNQDVINAIE-QDYRLPPPPDCPTSLHQLM 853 Query: 2776 RDCWQKDPNLRPSFIQLTSYLKTLQR 2853 DCWQKD N RP F Q+ S L + R Sbjct: 854 LDCWQKDRNARPRFPQVVSALDKMIR 879
>Q91735:EPHB3_XENLA Ephrin type-B receptor 3 precursor - Xenopus laevis (African clawed| frog) Length = 974 Score = 127 bits (318), Expect = 4e-28 Identities = 83/266 (31%), Positives = 129/266 (48%), Gaps = 10/266 (3%) Frame = +1 Query: 2086 IDERIGIGSYGEVYHADWNGT----EVAVKKFLDQEFYGDALEEFRCEVRIMRRLRHPNI 2253 I+E IG G +GEV + K L + +F E IM + HPNI Sbjct: 611 IEEVIGAGEFGEVCRGKLKQAGRREQFVAIKTLKAGYTEQQRRDFLGEASIMGQFDHPNI 670 Query: 2254 VLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGMNCLHTSVP 2433 + G VTR + I++E++ G+L + + Q + + + +A GM L S Sbjct: 671 IRLEGVVTRSRPVMILTEFMENGALDSFLRMNDGQFTVIQLVGILRGIASGMKYL--SEM 728 Query: 2434 TIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHS-----TFLSSKSTAGTPEWMAPEVLRN 2598 VHRDL + N+LV+ N KV DFGLSR + T+ S+ W APE + Sbjct: 729 NYVHRDLAARNILVNSNLVCKVSDFGLSRFLENSRSDPTYTSALGGKIPIRWTAPEAISY 788 Query: 2599 EQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVASII 2775 + D++S+G+++WE+ + +P+ M+ V+ A+ QD RL P + + ++ Sbjct: 789 RKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVINAIE-QDYRLPPPMDCPSALHQLM 847 Query: 2776 RDCWQKDPNLRPSFIQLTSYLKTLQR 2853 DCW +D NLRP F Q+ S L L R Sbjct: 848 LDCWLRDRNLRPKFSQIVSSLDKLIR 873
>P54763:EPHB2_MOUSE Ephrin type-B receptor 2 precursor - Mus musculus (Mouse)| Length = 994 Score = 127 bits (318), Expect = 4e-28 Identities = 84/267 (31%), Positives = 133/267 (49%), Gaps = 11/267 (4%) Frame = +1 Query: 2086 IDERIGIGSYGEVY--HADWNGTE---VAVKKFLDQEFYGDALEEFRCEVRIMRRLRHPN 2250 I++ IG G +GEV H G VA+K L + +F E IM + HPN Sbjct: 631 IEQVIGAGEFGEVCSGHLKLPGKREIFVAIKT-LKSGYTEKQRRDFLSEASIMGQFDHPN 689 Query: 2251 IVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGMNCLHTSV 2430 ++ G VT+ + I++E++ GSL + + + Q + + M +A GM L + Sbjct: 690 VIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGMKYL--AD 747 Query: 2431 PTIVHRDLKSPNLLVDDNWTVKVCDFGLSRL-----KHSTFLSSKSTAGTPEWMAPEVLR 2595 VHRDL + N+LV+ N KV DFGLSR T+ S+ W APE ++ Sbjct: 748 MNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQ 807 Query: 2596 NEQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVASI 2772 + D++S+G+++WE+ + +P+ M V+ A+ QD RL P + + + Sbjct: 808 YRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIE-QDYRLPPPMDCPSALHQL 866 Query: 2773 IRDCWQKDPNLRPSFIQLTSYLKTLQR 2853 + DCWQKD N RP F Q+ + L + R Sbjct: 867 MLDCWQKDRNHRPKFGQIVNTLDKMIR 893
>P29323:EPHB2_HUMAN Ephrin type-B receptor 2 precursor - Homo sapiens (Human)| Length = 1055 Score = 127 bits (318), Expect = 4e-28 Identities = 84/267 (31%), Positives = 133/267 (49%), Gaps = 11/267 (4%) Frame = +1 Query: 2086 IDERIGIGSYGEVY--HADWNGTE---VAVKKFLDQEFYGDALEEFRCEVRIMRRLRHPN 2250 I++ IG G +GEV H G VA+K L + +F E IM + HPN Sbjct: 623 IEQVIGAGEFGEVCSGHLKLPGKREIFVAIKT-LKSGYTEKQRRDFLSEASIMGQFDHPN 681 Query: 2251 IVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGMNCLHTSV 2430 ++ G VT+ + I++E++ GSL + + + Q + + M +A GM L + Sbjct: 682 VIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGMKYL--AD 739 Query: 2431 PTIVHRDLKSPNLLVDDNWTVKVCDFGLSRL-----KHSTFLSSKSTAGTPEWMAPEVLR 2595 VHRDL + N+LV+ N KV DFGLSR T+ S+ W APE ++ Sbjct: 740 MNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQ 799 Query: 2596 NEQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVASI 2772 + D++S+G+++WE+ + +P+ M V+ A+ QD RL P + + + Sbjct: 800 YRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIE-QDYRLPPPMDCPSALHQL 858 Query: 2773 IRDCWQKDPNLRPSFIQLTSYLKTLQR 2853 + DCWQKD N RP F Q+ + L + R Sbjct: 859 MLDCWQKDRNHRPKFGQIVNTLDKMIR 885
>Q91287:FGFR3_PLEWA Fibroblast growth factor receptor 3 precursor - Pleurodeles waltlii| (Iberian ribbed newt) Length = 796 Score = 126 bits (317), Expect = 5e-28 Identities = 107/331 (32%), Positives = 162/331 (48%), Gaps = 36/331 (10%) Frame = +1 Query: 2020 SSKVDLVLDEVSECEI----LWE----DLVIDERIGIGSYGEVYHADWNG---------T 2148 SS +L VSE E+ WE L + + +G G +G+V AD G T Sbjct: 429 SSSDGPMLANVSELELPADPKWELSRSRLTLGKPLGEGCFGQVVMADAVGIEKDKPNKAT 488 Query: 2149 EVAVKKFLDQEFYGDALEEFRCEVRIMRRL-RHPNIVLFMGAVTRPPHLSIVSEYLPRGS 2325 VAVK D D L + E+ +M+ + +H NI+ +GA T+ L ++ EY +G+ Sbjct: 489 SVAVKMLKDDATDKD-LSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVLVEYASKGN 547 Query: 2326 L--YKIIHRP--------NCQIDE-----KRRIKMALDVARGMNCLHTSVPTIVHRDLKS 2460 L Y RP C++ E K + A VARGM L + +HRDL + Sbjct: 548 LREYLRARRPPGMDYSFDTCKLPEEQLTFKDLVSCAYQVARGMEYLASQ--KCIHRDLAA 605 Query: 2461 PNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAGT--PEWMAPEVLRNEQSNEKCDIYSF 2634 N+LV D+ +K+ DFGL+R H+ K+T G +WMAPE L + + D++SF Sbjct: 606 RNVLVTDDNVMKIADFGLARDVHNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSF 665 Query: 2635 GVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVASIIRDCWQKDPNLRP 2811 GV+LWE+ TL P+ G+ ++ + + R+D P + I+R+CW P+ RP Sbjct: 666 GVLLWEIFTLGGSPYPGIPVEELFKLLK-EGHRMDKPANCTHELYMIMRECWHAVPSQRP 724 Query: 2812 SFIQLTSYLKTLQRLVIPSHQETASNHVPYE 2904 +F QL L + L + S E VP+E Sbjct: 725 TFKQLVEDLDRV--LTVTSTDEYLDLSVPFE 753
>P28693:EPHB2_CHICK Ephrin type-B receptor 2 precursor - Gallus gallus (Chicken)| Length = 1004 Score = 126 bits (317), Expect = 5e-28 Identities = 84/267 (31%), Positives = 133/267 (49%), Gaps = 11/267 (4%) Frame = +1 Query: 2086 IDERIGIGSYGEVY--HADWNGTE---VAVKKFLDQEFYGDALEEFRCEVRIMRRLRHPN 2250 I++ IG G +GEV H G VA+K L + +F E IM + HPN Sbjct: 641 IEQVIGAGEFGEVCSGHLKLPGKREIFVAIKT-LKSGYTEKQRRDFLSEASIMGQFDHPN 699 Query: 2251 IVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGMNCLHTSV 2430 ++ G VT+ + I++E++ GSL + + + Q + + M +A GM L + Sbjct: 700 VIHLEGVVTKSSPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGMKYL--AD 757 Query: 2431 PTIVHRDLKSPNLLVDDNWTVKVCDFGLSRL-----KHSTFLSSKSTAGTPEWMAPEVLR 2595 VHRDL + N+LV+ N KV DFGLSR T+ S+ W APE ++ Sbjct: 758 MNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQ 817 Query: 2596 NEQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVASI 2772 + D++S+G+++WE+ + +P+ M V+ A+ QD RL P + + + Sbjct: 818 YRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIE-QDYRLPPPMDCPNALHQL 876 Query: 2773 IRDCWQKDPNLRPSFIQLTSYLKTLQR 2853 + DCWQKD N RP F Q+ + L + R Sbjct: 877 MLDCWQKDRNHRPKFGQIVNTLDKMIR 903
>P00526:SRC_RSVP Tyrosine-protein kinase transforming protein Src - Rous sarcoma virus| (strain Prague C) (RSV-PrC) Length = 526 Score = 126 bits (316), Expect = 7e-28 Identities = 88/263 (33%), Positives = 136/263 (51%), Gaps = 4/263 (1%) Frame = +1 Query: 2062 EILWEDLVIDERIGIGSYGEVYHADWNGT-EVAVKKFLDQEFYGDALEEFRCEVRIMRRL 2238 EI E L ++ ++G G +GEV+ WN T VA+K +A F E ++M++L Sbjct: 261 EIPRESLRLEAKLGQGCFGEVWMGTWNDTTRVAIKTLKPGTMSPEA---FLQEAQVMKKL 317 Query: 2239 RHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIH-RPNCQIDEKRRIKMALDVARGMNC 2415 RH +V V+ P + IV EY+ +GSL + + + + MA +A GM Sbjct: 318 RHEKLVQLYAVVSEEP-IYIVIEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGM-- 374 Query: 2416 LHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAGTP-EWMAPEVL 2592 + VHRDL++ N+LV +N KV DFGL+RL +++ A P +W APE Sbjct: 375 AYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAA 434 Query: 2593 RNEQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVAS 2769 + K D++SFG++L EL T R P+ GM +V+ V + R+ P E + Sbjct: 435 LYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVE-RGYRMPCPPECPESLHD 493 Query: 2770 IIRDCWQKDPNLRPSFIQLTSYL 2838 ++ CW+KDP RP+F L + L Sbjct: 494 LMCQCWRKDPEERPTFKYLQAQL 516
>O43353:RIPK2_HUMAN Receptor-interacting serine/threonine-protein kinase 2 - Homo sapiens| (Human) Length = 540 Score = 126 bits (316), Expect = 7e-28 Identities = 89/284 (31%), Positives = 143/284 (50%), Gaps = 24/284 (8%) Frame = +1 Query: 2077 DLVIDERIGIGSYGEVYHADWNGTEVAVKKF-LDQEFYGDALEEFRCEVRIMRRLRHPNI 2253 DL R G+ HADW +VAVK + ++ E I+ + R I Sbjct: 20 DLRYLSRGASGTVSSARHADWR-VQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYI 78 Query: 2254 VLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEK--RRIKMALDVARGMNCLHTS 2427 + +G P L IV+EY+P GSL +++HR D R ++ ++A G+N LH Sbjct: 79 LPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNM 138 Query: 2428 VPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAGTPE-----WMAPEVL 2592 P ++H DLK+ N+L+D+ + VK+ DFGLS+ + + S+S+ PE +M PE Sbjct: 139 TPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENY 198 Query: 2593 RNEQSNE---KCDIYSFGVILWELATLRKPWHGM-NQMQVVGAVGFQDRRL--------D 2736 Q + K DIYS+ VI WE+ + ++P+ + N +Q++ +V R + D Sbjct: 199 EPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYD 258 Query: 2737 IPKEVDPIVASIIRDCWQKDPNLRPSF----IQLTSYLKTLQRL 2856 IP I S+I W ++P+ RPSF I+L L+T + + Sbjct: 259 IPHRARMI--SLIESGWAQNPDERPSFLKCLIELEPVLRTFEEI 300
>Q95KR7:LCK_SAISC Proto-oncogene tyrosine-protein kinase LCK - Saimiri sciureus (Common| squirrel monkey) Length = 509 Score = 126 bits (316), Expect = 7e-28 Identities = 84/266 (31%), Positives = 139/266 (52%), Gaps = 4/266 (1%) Frame = +1 Query: 2056 ECEILWEDLVIDERIGIGSYGEVYHADWNG-TEVAVKKFLDQEFYGDALEEFRCEVRIMR 2232 E E+ E L + ER+G G +GEV+ +N T+VAVK DA F E +M+ Sbjct: 237 EWEVPRETLKLVERLGAGQFGEVWMGYYNEHTKVAVKSLKQGSMSPDA---FLAEANLMK 293 Query: 2233 RLRHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPN-CQIDEKRRIKMALDVARGM 2409 +L+H +V VT P + I++EY+ GSL + P+ ++ + + MA + GM Sbjct: 294 QLQHKRLVRLYAVVTEEP-IYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIVEGM 352 Query: 2410 NCLHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAGTP-EWMAPE 2586 L +HRDL++ N+LV D + K+ DFGL+RL +++ A P +W APE Sbjct: 353 AFLEER--NYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPE 410 Query: 2587 VLRNEQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIV 2763 + K D++SFG+++ E+ T R P+ GM +V+ + + R+ P + Sbjct: 411 AINYGTFTIKSDVWSFGILMTEIVTHGRIPYPGMTNPEVIQNLE-RGYRMPRPDNCPEEL 469 Query: 2764 ASIIRDCWQKDPNLRPSFIQLTSYLK 2841 ++ CW++ P+ RP+F L S L+ Sbjct: 470 YKLMMQCWRERPDDRPTFDYLRSVLE 495
>P42685:FRK_HUMAN Tyrosine-protein kinase FRK - Homo sapiens (Human)| Length = 505 Score = 126 bits (316), Expect = 7e-28 Identities = 84/268 (31%), Positives = 136/268 (50%), Gaps = 6/268 (2%) Frame = +1 Query: 2032 DLVLDEVSECEILWEDLVIDERIGIGSYGEVYHADWNGTEVAVKKFLDQEFYGDALEEFR 2211 DL V + EI + + +R+G G +GEV+ WN T K L +F Sbjct: 218 DLSYKTVDQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDP--NDFL 275 Query: 2212 CEVRIMRRLRHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPN-CQIDEKRRIKMA 2388 E +IM+ LRHP ++ T + I++E + GSL + + +I +++ MA Sbjct: 276 REAQIMKNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMA 335 Query: 2389 LDVARGMNCLHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRL---KHSTFLSSKSTA 2559 VA GM L + +HRDL + N+LV ++ KV DFGL+R+ + S+ Sbjct: 336 AQVASGMAYLESR--NYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEI 393 Query: 2560 GTP-EWMAPEVLRNEQSNEKCDIYSFGVILWELATLRK-PWHGMNQMQVVGAVGFQDRRL 2733 P +W APE +R+ + + K D++SFG++L+E+ T K P+ GM QV+ + Q+ RL Sbjct: 394 KLPVKWTAPEAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLA-QNYRL 452 Query: 2734 DIPKEVDPIVASIIRDCWQKDPNLRPSF 2817 P +I+ +CW +P RP+F Sbjct: 453 PQPSNCPQQFYNIMLECWNAEPKERPTF 480
>P54760:EPHB4_HUMAN Ephrin type-B receptor 4 precursor - Homo sapiens (Human)| Length = 987 Score = 126 bits (316), Expect = 7e-28 Identities = 85/266 (31%), Positives = 127/266 (47%), Gaps = 10/266 (3%) Frame = +1 Query: 2086 IDERIGIGSYGEVYH----ADWNGTEVAVKKFLDQEFYGDALEEFRCEVRIMRRLRHPNI 2253 I+E IG G +GEV A K L + EF E IM + HPNI Sbjct: 617 IEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTERQRREFLSEASIMGQFEHPNI 676 Query: 2254 VLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGMNCLHTSVP 2433 + G VT + I++E++ G+L + + Q + + M +A GM L + Sbjct: 677 IRLEGVVTNSMPVMILTEFMENGALDSFLRLNDGQFTVIQLVGMLRGIASGMRYL--AEM 734 Query: 2434 TIVHRDLKSPNLLVDDNWTVKVCDFGLSRL-----KHSTFLSSKSTAGTPEWMAPEVLRN 2598 + VHRDL + N+LV+ N KV DFGLSR T+ SS W APE + Sbjct: 735 SYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTYTSSLGGKIPIRWTAPEAIAF 794 Query: 2599 EQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVASII 2775 + D +S+G+++WE+ + +P+ M+ V+ A+ QD RL P + + ++ Sbjct: 795 RKFTSASDAWSYGIVMWEVMSFGERPYWDMSNQDVINAIE-QDYRLPPPPDCPTSLHQLM 853 Query: 2776 RDCWQKDPNLRPSFIQLTSYLKTLQR 2853 DCWQKD N RP F Q+ S L + R Sbjct: 854 LDCWQKDRNARPRFPQVVSALDKMIR 879
>O13146:EPHA3_DANRE Ephrin type-A receptor 3 precursor - Danio rerio (Zebrafish)| (Brachydanio rerio) Length = 981 Score = 126 bits (316), Expect = 7e-28 Identities = 93/299 (31%), Positives = 149/299 (49%), Gaps = 10/299 (3%) Frame = +1 Query: 2038 VLDEVSECEILWEDLVIDERIGIGSYGEVYHA-----DWNGTEVAVKKFLDQEFYGDALE 2202 V D E E+ ++ I+ IG G +GEV +VA+K L + Sbjct: 614 VRDFAKEIEV--SNIRIERVIGAGEFGEVCSGRLRLPSKREIQVAIKS-LKAGYSEHQRR 670 Query: 2203 EFRCEVRIMRRLRHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIK 2382 +F E IM + HPNI+ G VTR + IV+EY+ GSL + + + Q + + Sbjct: 671 DFLSEASIMGQFDHPNIIRLEGVVTRCKPVMIVTEYMENGSLDTFLKKHDGQFTVIQLLG 730 Query: 2383 MALDVARGMNCLHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAG 2562 M +A GM L S VHRDL + N+LV+ N KV DFGLSR+ ++ +T G Sbjct: 731 MLRGIAAGMQYL--SEMNYVHRDLAARNILVNRNLVCKVSDFGLSRVLEDDPEAAYTTRG 788 Query: 2563 TP---EWMAPEVLRNEQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRR 2730 W APE + + D++S+G+++WE+ + +P+ M+ V+ AV + R Sbjct: 789 GKIPIRWTAPEAITYRKFTSASDVWSYGIVMWEVISYGERPYWEMSNQDVIKAVD-EGYR 847 Query: 2731 LDIPKEVDPIVASIIRDCWQKDPNLRPSFIQLTSYLKTLQRLV-IPSHQETASNHVPYE 2904 L P + ++ ++ DCW+K+ + RP F Q+ + TL RL+ PS + +N +E Sbjct: 848 LPAPMDCPVVLHQLMLDCWEKNRSDRPKFGQI---VNTLDRLIRNPSSLKQLANSAVWE 903
>Q9LJF3:BRL3_ARATH Serine/threonine-protein kinase BRI1-like 3 precursor - Arabidopsis| thaliana (Mouse-ear cress) Length = 1164 Score = 126 bits (316), Expect = 7e-28 Identities = 76/203 (37%), Positives = 119/203 (58%), Gaps = 8/203 (3%) Frame = +1 Query: 2089 DERIGIGSYGEVYHADW-NGTEVAVKKFLDQEFYGDALEEFRCEVRIMRRLRHPNIVLFM 2265 D IG G +G+VY A +G+ VA+KK + GD EF E+ + +++H N+V + Sbjct: 861 DSMIGSGGFGDVYKAKLADGSVVAIKKLIQVTGQGD--REFMAEMETIGKIKHRNLVPLL 918 Query: 2266 GAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQ----IDEKRRIKMALDVARGMNCLHTS-V 2430 G +V EY+ GSL ++H + +D R K+A+ ARG+ LH S + Sbjct: 919 GYCKIGEERLLVYEYMKYGSLETVLHEKTKKGGIFLDWSARKKIAIGAARGLAFLHHSCI 978 Query: 2431 PTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHS--TFLSSKSTAGTPEWMAPEVLRNEQ 2604 P I+HRD+KS N+L+D ++ +V DFG++RL + T LS + AGTP ++ PE ++ + Sbjct: 979 PHIIHRDMKSSNVLLDQDFVARVSDFGMARLVSALDTHLSVSTLAGTPGYVPPEYYQSFR 1038 Query: 2605 SNEKCDIYSFGVILWELATLRKP 2673 K D+YS+GVIL EL + +KP Sbjct: 1039 CTAKGDVYSYGVILLELLSGKKP 1061
>Q5GIG6:TNI3K_MOUSE Serine/threonine-protein kinase TNNI3K - Mus musculus (Mouse)| Length = 834 Score = 125 bits (315), Expect = 9e-28 Identities = 86/301 (28%), Positives = 145/301 (48%), Gaps = 4/301 (1%) Frame = +1 Query: 1951 SPLDRFMDRPRQNIECVSPSQVGSSKVDLVLDEVSECEILWEDLVIDERIGIGSYGEVYH 2130 SPL + ++ + + S+ L L E+ EI IG GS+G+VY Sbjct: 429 SPLGKIKSMTKEKADVLLLRAELPSRFHLQLSEIEFHEI----------IGSGSFGKVYK 478 Query: 2131 ADWNGTEVAVKKFLDQEFYGDALEEFRC-EVRIMRRLRHPNIVLFMGA-VTRPPHLSIVS 2304 VA+K++ + + + C EV I+ +L HP +V F+GA + P +IV+ Sbjct: 479 GRCRNKIVAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVVQFVGACLDDPSQFAIVT 538 Query: 2305 EYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGMNCLHTSVPTIVHRDLKSPNLLVDDN 2484 +Y+ GSL+ ++H +D + ++ +A+DVA+GM LH+ I+HRDL S N+L+ ++ Sbjct: 539 QYISGGSLFSLLHEQKRILDLQSKLIIAVDVAKGMEYLHSLTQPIIHRDLNSHNILLYED 598 Query: 2485 WTVKVCDFGLSRLKHSTFLSSKS-TAGTPEWMAPEVLRN-EQSNEKCDIYSFGVILWELA 2658 V DFG SR S + + G WMAPEV + K D++S+ + LWEL Sbjct: 599 GHAVVADFGESRFLQSLDEDNMTKQPGNLRWMAPEVFTQCTRYTIKADVFSYALCLWELL 658 Query: 2659 TLRKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVASIIRDCWQKDPNLRPSFIQLTSYL 2838 P+ + + + R I + ++S++ W P RP F ++ L Sbjct: 659 IGEIPFAHLKPAAAAADMAYHHIRPPIGYSIPKPISSLLMRGWNACPEGRPEFSEVVRKL 718 Query: 2839 K 2841 + Sbjct: 719 E 719
>Q59H18:TNI3K_HUMAN Serine/threonine-protein kinase TNNI3K - Homo sapiens (Human)| Length = 936 Score = 125 bits (315), Expect = 9e-28 Identities = 77/259 (29%), Positives = 132/259 (50%), Gaps = 4/259 (1%) Frame = +1 Query: 2077 DLVIDERIGIGSYGEVYHADWNGTEVAVKKFLDQEFYGDALEEFRC-EVRIMRRLRHPNI 2253 ++ E IG GS+G+VY VA+K++ + + + C EV I+ +L HP + Sbjct: 563 EIEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCV 622 Query: 2254 VLFMGA-VTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGMNCLHTSV 2430 + F+GA + P +IV++Y+ GSL+ ++H +D + ++ +A+DVA+GM LH Sbjct: 623 IQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIAVDVAKGMEYLHNLT 682 Query: 2431 PTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKS-TAGTPEWMAPEVLRN-EQ 2604 I+HRDL S N+L+ ++ V DFG SR S + + G WMAPEV + Sbjct: 683 QPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNLRWMAPEVFTQCTR 742 Query: 2605 SNEKCDIYSFGVILWELATLRKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVASIIRDC 2784 K D++S+ + LWE+ T P+ + + + R I + ++S++ Sbjct: 743 YTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYHHIRPPIGYSIPKPISSLLIRG 802 Query: 2785 WQKDPNLRPSFIQLTSYLK 2841 W P RP F ++ L+ Sbjct: 803 WNACPEGRPEFSEVVMKLE 821
>Q62190:RON_MOUSE Macrophage-stimulating protein receptor precursor - Mus musculus| (Mouse) Length = 1378 Score = 125 bits (315), Expect = 9e-28 Identities = 93/291 (31%), Positives = 143/291 (49%), Gaps = 12/291 (4%) Frame = +1 Query: 2035 LVLDEVSECEILWEDLVI--DERIGIGSYGEVYHADW-----NGTEVAVKKFLDQEFYGD 2193 ++L EV + I E +VI D+ IG G +G VYH ++ N T A+K L + Sbjct: 1042 MLLAEVKDVLIPHEQVVIHTDQVIGKGHFGVVYHGEYTDGAQNQTHCAIKS-LSRITEVQ 1100 Query: 2194 ALEEFRCEVRIMRRLRHPNIVLFMGAVTRPPHLS-IVSEYLPRGSLYKIIHRPNCQIDEK 2370 +E F E +MR L HPNI+ +G + P L ++ Y+ G L + I P K Sbjct: 1101 EVEAFLREGLLMRGLHHPNILALIGIMLPPEGLPRVLLPYMRHGDLLRFIRSPQRNPTVK 1160 Query: 2371 RRIKMALDVARGMNCLHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSR----LKHSTF 2538 + L VA GM L + VHRDL + N ++D+++TVKV DFGL+R ++ + Sbjct: 1161 DLVSFGLQVACGMEYL--AEQKFVHRDLAARNCMLDESFTVKVADFGLARGVLDKEYYSV 1218 Query: 2539 LSSKSTAGTPEWMAPEVLRNEQSNEKCDIYSFGVILWELATLRKPWHGMNQMQVVGAVGF 2718 + +WMA E L+ + K D++SFGV+LWEL T P + + Sbjct: 1219 RQHRHARLPVKWMALESLQTYRFTTKSDVWSFGVLLWELLTRGAPPYPHIDPFDLSHFLA 1278 Query: 2719 QDRRLDIPKEVDPIVASIIRDCWQKDPNLRPSFIQLTSYLKTLQRLVIPSH 2871 Q RRL P+ + ++ CW+ DP RP+F L +K + ++ H Sbjct: 1279 QGRRLPQPEYCPDSLYHVMLRCWEADPAARPTFRALVLEVKQVVASLLGDH 1329
>P58801:RIPK2_MOUSE Receptor-interacting serine/threonine-protein kinase 2 - Mus musculus| (Mouse) Length = 539 Score = 125 bits (315), Expect = 9e-28 Identities = 88/281 (31%), Positives = 145/281 (51%), Gaps = 23/281 (8%) Frame = +1 Query: 2077 DLVIDERIGIGSYGEVYHADWNGTEVAVKKF-LDQEFYGDALEEFRCEVRIMRRLRHPNI 2253 DL R G+ HADW VAVK + + E I+ + R I Sbjct: 20 DLHYLSRGASGTVSSARHADWR-VRVAVKHLHIHTPLLDSERNDILREAEILHKARFSYI 78 Query: 2254 VLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPN--CQIDEKRRIKMALDVARGMNCLHTS 2427 + +G P L IV+EY+P GSL +++HR I R ++ ++A G+N LH Sbjct: 79 LPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDIAWPLRFRILHEIALGVNYLHNM 138 Query: 2428 VPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAGTPE-----WMAPEVL 2592 P ++H DLK+ N+L+D+ + VK+ DFGLS+ + + S+S PE +M PE Sbjct: 139 NPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSYKSAPEGGTIIYMPPENY 198 Query: 2593 ---RNEQSNEKCDIYSFGVILWELATLRKPWHGM-NQMQVVGAVGFQDRRLDIPKEVDP- 2757 + +++ K DIYS+ VI+WE+ + ++P+ + N +Q++ +V Q R D +E P Sbjct: 199 EPGQKSRASVKHDIYSYAVIMWEVLSRKQPFEEVTNPLQIMYSVS-QGHRPDTSEENLPF 257 Query: 2758 ------IVASIIRDCWQKDPNLRPSF----IQLTSYLKTLQ 2850 ++ S+I+ W ++P+ RPSF I+L L+T + Sbjct: 258 DIPHRGLMISLIQSGWAQNPDERPSFLKCLIELEPVLRTFE 298
>Q9V3Q6:M3K7_DROME Mitogen-activated protein kinase kinase kinase 7 - Drosophila| melanogaster (Fruit fly) Length = 678 Score = 125 bits (315), Expect = 9e-28 Identities = 75/263 (28%), Positives = 133/263 (50%), Gaps = 5/263 (1%) Frame = +1 Query: 2041 LDEVSECEILWEDLVIDERIGIGSYGEVYHADWNGTEVAVKKFLDQEFYGDALEEFRCEV 2220 LD + + + ++ + E++G GSYG V A W VAVK+F F ++ EV Sbjct: 6 LDALQAAYVDFSEITLREKVGHGSYGVVCKAVWRDKLVAVKEF----FASAEQKDIEKEV 61 Query: 2221 RIMRRLRHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIH---RPNCQIDEKRRIKMAL 2391 + + R++HPNI+ G + ++ E+ GSL+ +H +P + + A Sbjct: 62 KQLSRVKHPNIIALHGISSYQQATYLIMEFAEGGSLHNFLHGKVKPAYSL--AHAMSWAR 119 Query: 2392 DVARGMNCLHTSVPT-IVHRDLKSPNLLVDDNW-TVKVCDFGLSRLKHSTFLSSKSTAGT 2565 A G+ LH P ++HRD+K NLL+ + +K+CDFG K + +++ +A Sbjct: 120 QCAEGLAYLHAMTPKPLIHRDVKPLNLLLTNKGRNLKICDFGTVADKSTMMTNNRGSAA- 178 Query: 2566 PEWMAPEVLRNEQSNEKCDIYSFGVILWELATLRKPWHGMNQMQVVGAVGFQDRRLDIPK 2745 WMAPEV + EKCDI+S+ ++LWE+ + ++P+ G++ + ++ R + Sbjct: 179 --WMAPEVFEGSKYTEKCDIFSWAIVLWEVLSRKQPFKGIDNAYTIQWKIYKGERPPLLT 236 Query: 2746 EVDPIVASIIRDCWQKDPNLRPS 2814 + ++ CW+ P RPS Sbjct: 237 TCPKRIEDLMTACWKTVPEDRPS 259
>Q922K9:FRK_MOUSE Tyrosine-protein kinase FRK - Mus musculus (Mouse)| Length = 512 Score = 125 bits (315), Expect = 9e-28 Identities = 85/268 (31%), Positives = 134/268 (50%), Gaps = 6/268 (2%) Frame = +1 Query: 2032 DLVLDEVSECEILWEDLVIDERIGIGSYGEVYHADWNGTEVAVKKFLDQEFYGDALEEFR 2211 DL + EI + + +R+G G +GEV+ WN T K L +F Sbjct: 225 DLSYKTADQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDP--NDFL 282 Query: 2212 CEVRIMRRLRHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPN-CQIDEKRRIKMA 2388 E +IM+ LRHP ++ T + I++E + GSL + + +I +++ MA Sbjct: 283 REAQIMKSLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDGGSKIHLIQQVDMA 342 Query: 2389 LDVARGMNCLHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRL---KHSTFLSSKSTA 2559 VA GM L + +HRDL + N+LV ++ KV DFGL+R+ + SK Sbjct: 343 AQVASGMAYLESQ--NYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESKHEI 400 Query: 2560 GTP-EWMAPEVLRNEQSNEKCDIYSFGVILWELATLRK-PWHGMNQMQVVGAVGFQDRRL 2733 P +W APE +R + + K D++SFG++L+E+ T K P+ GM QV+ + Q+ RL Sbjct: 401 KLPVKWTAPEAIRTNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLS-QNYRL 459 Query: 2734 DIPKEVDPIVASIIRDCWQKDPNLRPSF 2817 P SI+ +CW +P RP+F Sbjct: 460 PQPSNCPQQFYSIMLECWNVEPKQRPTF 487
>Q8L899:BRI1_SOLPE Systemin receptor SR160 precursor - Solanum peruvianum (Peruvian| tomato) (Lycopersicon peruvianum) Length = 1207 Score = 125 bits (315), Expect = 9e-28 Identities = 73/202 (36%), Positives = 121/202 (59%), Gaps = 7/202 (3%) Frame = +1 Query: 2089 DERIGIGSYGEVYHADW-NGTEVAVKKFLDQEFYGDALEEFRCEVRIMRRLRHPNIVLFM 2265 D +G G +G+VY A +G+ VA+KK + GD EF E+ + +++H N+V + Sbjct: 891 DSLVGSGGFGDVYKAQLKDGSVVAIKKLIHVSGQGD--REFTAEMETIGKIKHRNLVPLL 948 Query: 2266 GAVTRPPHLSIVSEYLPRGSLYKIIH---RPNCQIDEKRRIKMALDVARGMNCLHTS-VP 2433 G +V EY+ GSL ++H + +++ R K+A+ ARG+ LH + +P Sbjct: 949 GYCKVGEERLLVYEYMKYGSLEDVLHDRKKTGIKLNWPARRKIAIGAARGLAFLHHNCIP 1008 Query: 2434 TIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHS--TFLSSKSTAGTPEWMAPEVLRNEQS 2607 I+HRD+KS N+L+D+N +V DFG++RL + T LS + AGTP ++ PE ++ + Sbjct: 1009 HIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPEYYQSFRC 1068 Query: 2608 NEKCDIYSFGVILWELATLRKP 2673 + K D+YS+GV+L EL T ++P Sbjct: 1069 STKGDVYSYGVVLLELLTGKQP 1090
>Q04912:RON_HUMAN Macrophage-stimulating protein receptor precursor - Homo sapiens| (Human) Length = 1400 Score = 125 bits (314), Expect = 1e-27 Identities = 91/291 (31%), Positives = 146/291 (50%), Gaps = 13/291 (4%) Frame = +1 Query: 2038 VLDEVSECEILWEDLVI--DERIGIGSYGEVYHADW-----NGTEVAVKKFLDQEFYGDA 2196 +L EV + I E +V D IG G +G VYH ++ N + A+K L + Sbjct: 1066 LLAEVKDVLIPHERVVTHSDRVIGKGHFGVVYHGEYIDQAQNRIQCAIKS-LSRITEMQQ 1124 Query: 2197 LEEFRCEVRIMRRLRHPNIVLFMGAVTRPPHLS-IVSEYLPRGSLYKIIHRPNCQIDEKR 2373 +E F E +MR L HPN++ +G + P L ++ Y+ G L + I P K Sbjct: 1125 VEAFLREGLLMRGLNHPNVLALIGIMLPPEGLPHVLLPYMCHGDLLQFIRSPQRNPTVKD 1184 Query: 2374 RIKMALDVARGMNCLHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSR----LKHSTFL 2541 I L VARGM L + VHRDL + N ++D+++TVKV DFGL+R ++ + Sbjct: 1185 LISFGLQVARGMEYL--AEQKFVHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQ 1242 Query: 2542 SSKSTAGTPEWMAPEVLRNEQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGF 2718 + +WMA E L+ + K D++SFGV+LWEL T P+ ++ + + Sbjct: 1243 QHRHARLPVKWMALESLQTYRFTTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLA- 1301 Query: 2719 QDRRLDIPKEVDPIVASIIRDCWQKDPNLRPSFIQLTSYLKTLQRLVIPSH 2871 Q RRL P+ + +++ CW+ DP +RP+F L ++ + ++ H Sbjct: 1302 QGRRLPQPEYCPDSLYQVMQQCWEADPAVRPTFRVLVGEVEQIVSALLGDH 1352
>Q5PXS1:LCK_AOTNA Proto-oncogene tyrosine-protein kinase LCK - Aotus nancymaae (Ma's| night monkey) Length = 509 Score = 125 bits (314), Expect = 1e-27 Identities = 85/266 (31%), Positives = 140/266 (52%), Gaps = 4/266 (1%) Frame = +1 Query: 2056 ECEILWEDLVIDERIGIGSYGEVYHADWNG-TEVAVKKFLDQEFYGDALEEFRCEVRIMR 2232 E E+ E L + ER+G G +GEV+ +N T+VAVK DA F E +M+ Sbjct: 237 EWEVPRETLKLVERLGAGQFGEVWMGYYNDHTKVAVKSLKQGSMSPDA---FLAEANLMK 293 Query: 2233 RLRHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPN-CQIDEKRRIKMALDVARGM 2409 +L+H +V VT+ P + I++EY+ GSL + P+ ++ + + MA +A GM Sbjct: 294 QLQHQRLVRLYAVVTQEP-IYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGM 352 Query: 2410 NCLHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAGTP-EWMAPE 2586 + +HRDL++ N+LV D + K+ DFGL+RL +++ A P +W APE Sbjct: 353 AFIEER--NYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPE 410 Query: 2587 VLRNEQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIV 2763 + K D++SFG++L E+ T R P+ GM +V+ + + R+ P + Sbjct: 411 AINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLE-RGYRMVRPDNCPEEL 469 Query: 2764 ASIIRDCWQKDPNLRPSFIQLTSYLK 2841 ++ CW++ P RP+F L S L+ Sbjct: 470 YHLMMLCWKERPEDRPTFDYLRSVLE 495
>O13147:EPHB3_DANRE Ephrin type-B receptor 3 - Danio rerio (Zebrafish) (Brachydanio| rerio) Length = 500 Score = 125 bits (314), Expect = 1e-27 Identities = 85/267 (31%), Positives = 132/267 (49%), Gaps = 11/267 (4%) Frame = +1 Query: 2086 IDERIGIGSYGEVYH-----ADWNGTEVAVKKFLDQEFYGDALEEFRCEVRIMRRLRHPN 2250 I+E IG G +GEV A T VA+K L + +F E IM + HPN Sbjct: 189 IEEVIGAGEFGEVCRGRLKQAGRKETTVAIKT-LKAGYTEHQRRDFLSEASIMGQFDHPN 247 Query: 2251 IVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGMNCLHTSV 2430 ++ G +TR + IV+E++ G+L + + + + + M +A GM L S Sbjct: 248 VIHLEGVLTRSCPVLIVTEFMENGALDSFLRLNDGRFTVTQLVGMLRGIAAGMKYL--SD 305 Query: 2431 PTIVHRDLKSPNLLVDDNWTVKVCDFGLSRL-----KHSTFLSSKSTAGTPEWMAPEVLR 2595 VHRDL + N+LV+ N KV DFGLSR T+ SS W APE + Sbjct: 306 MNYVHRDLAARNVLVNSNLVCKVSDFGLSRFLDDNSSDPTYTSSLGGKIPIRWTAPEAIA 365 Query: 2596 NEQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVASI 2772 + D++S+G+++WE+ + +P+ M+ V+ AV QD RL P + ++ + Sbjct: 366 FRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVMNAVE-QDYRLPPPMDCPAVLHQL 424 Query: 2773 IRDCWQKDPNLRPSFIQLTSYLKTLQR 2853 + +CW K+ N+RP F Q+ S L R Sbjct: 425 MLECWVKERNMRPRFGQIVSTLDKFLR 451
>Q90344:EPHB2_COTJA Ephrin type-B receptor 2 precursor - Coturnix coturnix japonica| (Japanese quail) Length = 987 Score = 125 bits (314), Expect = 1e-27 Identities = 84/267 (31%), Positives = 132/267 (49%), Gaps = 11/267 (4%) Frame = +1 Query: 2086 IDERIGIGSYGEVY--HADWNGTE---VAVKKFLDQEFYGDALEEFRCEVRIMRRLRHPN 2250 I++ IG G +GEV H G VA+K L + +F E IM + HPN Sbjct: 624 IEQVIGAGEFGEVCSGHLKLPGKREIFVAIKT-LKSGYTEKQRRDFLSEASIMGQFDHPN 682 Query: 2251 IVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGMNCLHTSV 2430 ++ G VT+ + I++E++ GSL + + + Q + + M +A GM L + Sbjct: 683 VIHLEGVVTKSSPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGMKYL--AD 740 Query: 2431 PTIVHRDLKSPNLLVDDNWTVKVCDFGLSRL-----KHSTFLSSKSTAGTPEWMAPEVLR 2595 VHRDL + N LV+ N KV DFGLSR T+ S+ W APE ++ Sbjct: 741 MNYVHRDLAARNTLVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQ 800 Query: 2596 NEQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVASI 2772 + D++S+G+++WE+ + +P+ M V+ A+ QD RL P + + + Sbjct: 801 YRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIE-QDYRLPPPMDCPNALHQL 859 Query: 2773 IRDCWQKDPNLRPSFIQLTSYLKTLQR 2853 + DCWQKD N RP F Q+ + L + R Sbjct: 860 MLDCWQKDRNHRPKFGQIVNTLDKMIR 886
>P41241:CSK_MOUSE Tyrosine-protein kinase CSK - Mus musculus (Mouse)| Length = 450 Score = 125 bits (314), Expect = 1e-27 Identities = 85/263 (32%), Positives = 139/263 (52%), Gaps = 4/263 (1%) Frame = +1 Query: 2074 EDLVIDERIGIGSYGEVYHADWNGTEVAVKKFLDQEFYGDALEEFRCEVRIMRRLRHPNI 2253 ++L + + IG G +G+V D+ G +VAVK + + F E +M +LRH N+ Sbjct: 193 KELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDA----TAQAFLAEASVMTQLRHSNL 248 Query: 2254 VLFMGAVTRPPH-LSIVSEYLPRGSLYKIIH-RPNCQIDEKRRIKMALDVARGMNCLHTS 2427 V +G + L IV+EY+ +GSL + R + +K +LDV M L + Sbjct: 249 VQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVLEAMEYLEGN 308 Query: 2428 VPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAGTP-EWMAPEVLRNEQ 2604 VHRDL + N+LV ++ KV DFGL++ ST + T P +W APE LR ++ Sbjct: 309 --NFVHRDLAARNVLVSEDNVAKVSDFGLTKEASST----QDTGKLPVKWTAPEALREKK 362 Query: 2605 SNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVASIIRD 2781 + K D++SFG++LWE+ + R P+ + VV V + ++D P P V ++++ Sbjct: 363 FSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVE-KGYKMDAPDGCPPAVYDVMKN 421 Query: 2782 CWQKDPNLRPSFIQLTSYLKTLQ 2850 C D RP+F+QL L+ ++ Sbjct: 422 CSHLDAATRPTFLQLREQLEHIK 444
>O22476:BRI1_ARATH Protein BRASSINOSTEROID INSENSITIVE 1 precursor - Arabidopsis| thaliana (Mouse-ear cress) Length = 1196 Score = 125 bits (314), Expect = 1e-27 Identities = 89/260 (34%), Positives = 142/260 (54%), Gaps = 9/260 (3%) Frame = +1 Query: 2089 DERIGIGSYGEVYHADW-NGTEVAVKKFLDQEFYGDALEEFRCEVRIMRRLRHPNIVLFM 2265 D IG G +G+VY A +G+ VA+KK + GD EF E+ + +++H N+V + Sbjct: 886 DSLIGSGGFGDVYKAILKDGSAVAIKKLIHVSGQGD--REFMAEMETIGKIKHRNLVPLL 943 Query: 2266 GAVTRPPHLSIVSEYLPRGSLYKIIHRPN---CQIDEKRRIKMALDVARGMNCLHTSV-P 2433 G +V E++ GSL ++H P +++ R K+A+ ARG+ LH + P Sbjct: 944 GYCKVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAFLHHNCSP 1003 Query: 2434 TIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHS--TFLSSKSTAGTPEWMAPEVLRNEQS 2607 I+HRD+KS N+L+D+N +V DFG++RL + T LS + AGTP ++ PE ++ + Sbjct: 1004 HIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPEYYQSFRC 1063 Query: 2608 NEKCDIYSFGVILWELATLRKPWHG--MNQMQVVGAVGFQDRRLDIPKEVDPIVASIIRD 2781 + K D+YS+GV+L EL T ++P +VG V Q +L I DP + Sbjct: 1064 STKGDVYSYGVVLLELLTGKRPTDSPDFGDNNLVGWVK-QHAKLRISDVFDP-------E 1115 Query: 2782 CWQKDPNLRPSFIQLTSYLK 2841 ++DP L I+L +LK Sbjct: 1116 LMKEDPALE---IELLQHLK 1132
>Q07407:FGFR1_DROME Fibroblast growth factor receptor homolog 1 precursor - Drosophila| melanogaster (Fruit fly) Length = 729 Score = 125 bits (313), Expect = 2e-27 Identities = 85/288 (29%), Positives = 146/288 (50%), Gaps = 23/288 (7%) Frame = +1 Query: 2053 SECEILWEDLVIDERIGIGSYGEVYHADWNGTEVAVKKFLDQEFYGDALEEFRCEVRIMR 2232 S E+ LV+ +G G++G V A+ N VAVK + D R E+ +M+ Sbjct: 407 SNWELPRSHLVLGATLGEGAFGRVVMAEVNNAIVAVKMVKEGHTDDDIASLVR-EMEVMK 465 Query: 2233 RL-RHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHR-------------------PN 2352 + RH NI+ +G ++ L ++ EY P G+L +++ P Sbjct: 466 IIGRHINIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNRPFGRDQDRDSSQPPPSPPA 525 Query: 2353 CQIDEKRRIKMALDVARGMNCLHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHS 2532 I EK IK A +ARGM+ L + +HRDL + N+LV D++ +K+ DFGL+R S Sbjct: 526 HVITEKDLIKFAHQIARGMDYLASR--RCIHRDLAARNVLVSDDYVLKIADFGLARDIQS 583 Query: 2533 TFLSSKSTAG--TPEWMAPEVLRNEQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVV 2703 T K+T G +WMAPE L+ + + K D++S+G++LWE+ T ++P+ + + + Sbjct: 584 TDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEEL 643 Query: 2704 GAVGFQDRRLDIPKEVDPIVASIIRDCWQKDPNLRPSFIQLTSYLKTL 2847 +R++ P + + ++R CW + + RP F ++ Y+ L Sbjct: 644 YTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYMDKL 691
>Q8GUQ5:BRI1_SOLLC Brassinosteroid LRR receptor kinase precursor - Solanum lycopersicum| (Tomato) (Lycopersicon esculentum) Length = 1207 Score = 125 bits (313), Expect = 2e-27 Identities = 73/202 (36%), Positives = 121/202 (59%), Gaps = 7/202 (3%) Frame = +1 Query: 2089 DERIGIGSYGEVYHADW-NGTEVAVKKFLDQEFYGDALEEFRCEVRIMRRLRHPNIVLFM 2265 D +G G +G+VY A +G+ VA+KK + GD EF E+ + +++H N+V + Sbjct: 891 DSLVGSGGFGDVYKAQLKDGSVVAIKKLIHVSGQGD--REFTAEMETIGKIKHRNLVPLL 948 Query: 2266 GAVTRPPHLSIVSEYLPRGSLYKIIH---RPNCQIDEKRRIKMALDVARGMNCLHTS-VP 2433 G +V EY+ GSL ++H + +++ R K+A+ ARG+ LH + +P Sbjct: 949 GYCKVGEERLLVYEYMKYGSLEDVLHDRKKIGIKLNWPARRKIAIGAARGLAFLHHNCIP 1008 Query: 2434 TIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHS--TFLSSKSTAGTPEWMAPEVLRNEQS 2607 I+HRD+KS N+L+D+N +V DFG++RL + T LS + AGTP ++ PE ++ + Sbjct: 1009 HIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPEYYQSFRC 1068 Query: 2608 NEKCDIYSFGVILWELATLRKP 2673 + K D+YS+GV+L EL T ++P Sbjct: 1069 STKGDVYSYGVVLLELLTGKQP 1090
>P21804:FGFR1_CHICK Basic fibroblast growth factor receptor 1 precursor - Gallus gallus| (Chicken) Length = 819 Score = 124 bits (311), Expect = 3e-27 Identities = 106/339 (31%), Positives = 168/339 (49%), Gaps = 37/339 (10%) Frame = +1 Query: 1999 VSPSQVGSSKVDLVLDEVSECEI----LWE----DLVIDERIGIGSYGEVYHADWNG--- 2145 V PS++ SS + L VSE E+ WE L++ + +G G +G+V A+ G Sbjct: 442 VRPSRLSSSGTPM-LAGVSEYELPEDPRWELPRDRLILGKPLGEGCFGQVVLAEAIGLDK 500 Query: 2146 ------TEVAVKKFLDQEFYGDALEEFRCEVRIMRRL-RHPNIVLFMGAVTRPPHLSIVS 2304 T+VAVK D L + E+ +M+ + +H NI+ +GA T+ L ++ Sbjct: 501 DKPNRVTKVAVKMLKSDATEKD-LSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIV 559 Query: 2305 EYLPRGSL---------------YKIIHRPNCQIDEKRRIKMALDVARGMNCLHTSVPTI 2439 EY +G+L Y P Q+ K + A VARGM L + Sbjct: 560 EYASKGNLREYLQARRPPGMEYCYNPTRIPEEQLSFKDLVSCAYQVARGMEYLASK--KC 617 Query: 2440 VHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAGT--PEWMAPEVLRNEQSNE 2613 +HRDL + N+LV ++ +K+ DFGL+R H K+T G +WMAPE L + Sbjct: 618 IHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTH 677 Query: 2614 KCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVASIIRDCWQ 2790 + D++SFGV+LWE+ TL P+ G+ ++ + + R+D P + ++RDCW Sbjct: 678 QSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLK-EGHRMDKPSNCTNELYMMMRDCWH 736 Query: 2791 KDPNLRPSFIQLTSYLKTLQRLV-IPSHQETASNHVPYE 2904 P+ RP+F QL ++ L R+V + S+QE VP + Sbjct: 737 AVPSQRPTFKQL---VEDLDRIVAMTSNQEYLDLSVPLD 772
>P28829:BYR2_SCHPO Protein kinase byr2 - Schizosaccharomyces pombe (Fission yeast)| Length = 659 Score = 124 bits (311), Expect = 3e-27 Identities = 90/322 (27%), Positives = 160/322 (49%), Gaps = 16/322 (4%) Frame = +1 Query: 1918 DHRMLHPDPRKSPLDRFMDRPRQNIECVSPSQVGSSKVDLVLDEVSECEILWEDLVIDER 2097 +H++L P SP F+++P +SP+ S + + ++ + I W + Sbjct: 349 NHQVLSFSPGSSP--SFIEQPSP----ISPTSTTSEDTNTLEEDTDDQSIKW---IRGAL 399 Query: 2098 IGIGSYGEVYHA--DWNGTEVAVKKFL------DQEFYGDALEEFRCEVRIMRRLRHPNI 2253 IG GS+G+VY +G +AVK+ + ++ + L+ E+ +++ L H +I Sbjct: 400 IGSGSFGQVYLGMNASSGELMAVKQVILDSVSESKDRHAKLLDALAGEIALLQELSHEHI 459 Query: 2254 VLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDE--KRRIKMALDVARGMNCLHTS 2427 V ++G+ HL+I EY+P GS+ ++ + K IK L +G+ LH+ Sbjct: 460 VQYLGSNLNSDHLNIFLEYVPGGSVAGLLTMYGSFEETLVKNFIKQTL---KGLEYLHSR 516 Query: 2428 VPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAGTPE------WMAPEV 2589 IVHRD+K N+LVD+ +K+ DFG+S+ S+K+ P WMAPEV Sbjct: 517 --GIVHRDIKGANILVDNKGKIKISDFGISKKLELNSTSTKTGGARPSFQGSSFWMAPEV 574 Query: 2590 LRNEQSNEKCDIYSFGVILWELATLRKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVAS 2769 ++ EK DI+S G ++ E+ T + P+ +QMQ + +G ++ + P + Sbjct: 575 VKQTMHTEKTDIWSLGCLVIEMLTSKHPYPNCDQMQAIFRIG-ENILPEFPSNISSSAID 633 Query: 2770 IIRDCWQKDPNLRPSFIQLTSY 2835 + + D NLRP+ +L S+ Sbjct: 634 FLEKTFAIDCNLRPTASELLSH 655
>P29322:EPHA8_HUMAN Ephrin type-A receptor 8 precursor - Homo sapiens (Human)| Length = 1005 Score = 124 bits (310), Expect = 3e-27 Identities = 100/312 (32%), Positives = 138/312 (44%), Gaps = 4/312 (1%) Frame = +1 Query: 1930 LHPDPRKSPLDRFMDRPRQNIECVSPSQVGSSKVDLVLDEVSECEILWEDLVIDERIGIG 2109 LH P K P +F P E P + G S E+ I E ++ G Sbjct: 597 LHHPPGKLPEPQFYAEPHTYEE---PGRAGRS----FTREIEASRIHIEKIIGSGDSGEV 649 Query: 2110 SYGEVYHADWNGTEVAVKKFLDQEFYGDALEEFRCEVRIMRRLRHPNIVLFMGAVTRPPH 2289 YG + VA+K L + +F E IM + HPNI+ G VTR Sbjct: 650 CYGRLRVPGQRDVPVAIKA-LKAGYTERQRRDFLSEASIMGQFDHPNIIRLEGVVTRGRL 708 Query: 2290 LSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGMNCLHTSVPTIVHRDLKSPNL 2469 IV+EY+ GSL + + Q + + M V GM L S VHRDL + N+ Sbjct: 709 AMIVTEYMENGSLDTFLRTHDGQFTIMQLVGMLRGVGAGMRYL--SDLGYVHRDLAARNV 766 Query: 2470 LVDDNWTVKVCDFGLSRLKHSTFLSSKSTAGTP---EWMAPEVLRNEQSNEKCDIYSFGV 2640 LVD N KV DFGLSR+ ++ +T G W APE + + D++SFGV Sbjct: 767 LVDSNLVCKVSDFGLSRVLEDDPDAAYTTTGGKIPIRWTAPEAIAFRTFSSASDVWSFGV 826 Query: 2641 ILWE-LATLRKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVASIIRDCWQKDPNLRPSF 2817 ++WE LA +P+ M V+ +V + RL P + ++ DCW KD RP F Sbjct: 827 VMWEVLAYGERPYWNMTNRDVISSVE-EGYRLPAPMGCPHALHQLMLDCWHKDRAQRPRF 885 Query: 2818 IQLTSYLKTLQR 2853 Q+ S L L R Sbjct: 886 SQIVSVLDALIR 897
>Q8JH64:BTK_CHICK Tyrosine-protein kinase BTK - Gallus gallus (Chicken)| Length = 657 Score = 124 bits (310), Expect = 3e-27 Identities = 82/258 (31%), Positives = 124/258 (48%), Gaps = 3/258 (1%) Frame = +1 Query: 2062 EILWEDLVIDERIGIGSYGEVYHADWNGT-EVAVKKFLDQEFYGDALEEFRCEVRIMRRL 2238 EI +DL + +G G +G V + W G VA+K + D EF E ++M L Sbjct: 394 EIDPKDLTFLKELGTGQFGVVKYGKWRGQYNVAIKMIREGSMSED---EFIDEAKVMMNL 450 Query: 2239 RHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGMNCL 2418 H +V G T+ + I++EY+ G L + + ++M DV M L Sbjct: 451 SHEKLVQLYGVCTKQRPIFIITEYMANGCLLNFLRETQRRFQPAELLEMCKDVCEAMEYL 510 Query: 2419 HTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSR-LKHSTFLSSKSTAGTPEWMAPEVLR 2595 + +HRDL + N LV+D VKV DFGLSR + + SS + W PEVL Sbjct: 511 ESK--QFLHRDLAARNCLVNDQGIVKVSDFGLSRYVLDDEYTSSMGSKFPVRWSPPEVLL 568 Query: 2596 NEQSNEKCDIYSFGVILWELATLRK-PWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVASI 2772 + + K D++SFGV++WE+ +L K P+ N + V Q RL P++ V +I Sbjct: 569 YSKFSSKSDVWSFGVLMWEVYSLGKMPYERFNNSETTEHV-IQGLRLYRPQQASERVYAI 627 Query: 2773 IRDCWQKDPNLRPSFIQL 2826 + CW + RP+F L Sbjct: 628 MYSCWHEKAEERPTFSAL 645
>P42689:SRK3_SPOLA Tyrosine-protein kinase SRK3 - Spongilla lacustris (Freshwater| sponge) Length = 334 Score = 123 bits (309), Expect = 4e-27 Identities = 80/265 (30%), Positives = 137/265 (51%), Gaps = 3/265 (1%) Frame = +1 Query: 2056 ECEILWEDLVIDERIGIGSYGEVYHADWNGTEVAVKKFLDQEFYGDALEEFRCEVRIMRR 2235 E EI + + ++G G++GEV+ WNGT K L + +++F E ++M++ Sbjct: 58 EWEIDRTTIQLQRKLGQGNFGEVWAGVWNGTTAVAVKTLKPDTM--EVKDFVQEAQVMKK 115 Query: 2236 LRHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKII-HRPNCQIDEKRRIKMALDVARGMN 2412 + HPN++ T + IV+E + GS+ + + H I + + M+ +A GM Sbjct: 116 IHHPNLLQLYAVCTIGEPIYIVTELMKYGSMLEYLKHGEGKNITLHQMVDMSAQIASGMT 175 Query: 2413 CLHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSR-LKHSTFLSSKSTAGTPEWMAPEV 2589 L + +HRDL + N+LV + KV DFGL+R +K + + T +W APE Sbjct: 176 YLEAH--SYIHRDLAARNILVGEGNVCKVADFGLARVIKEDIYNPREGTKFPIKWTAPEA 233 Query: 2590 LRNEQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVA 2766 + K D++SFGV++ E+ T R P+ GM QV+ AV + R+ P+ + Sbjct: 234 ALYNRFTIKSDVWSFGVLISEIVTHGRMPYPGMTNRQVLEAVD-RGYRMPCPEGCPDPLY 292 Query: 2767 SIIRDCWQKDPNLRPSFIQLTSYLK 2841 I+ CW+ +P+ RP+F L + L+ Sbjct: 293 KIMLSCWKHEPDDRPTFESLKNLLE 317
>O22042:M3K3_ARATH Mitogen-activated protein kinase kinase kinase 3 - Arabidopsis| thaliana (Mouse-ear cress) Length = 651 Score = 123 bits (309), Expect = 4e-27 Identities = 82/260 (31%), Positives = 135/260 (51%), Gaps = 12/260 (4%) Frame = +1 Query: 2092 ERIGIGSYGEVY---HADWNGTEVAVKKFL------DQEFYGDALEEFRCEVRIMRRLRH 2244 E IG G++G VY + D +G +A+K+ L +E + E EV++++ L H Sbjct: 72 ELIGCGAFGRVYMGMNLD-SGELLAIKQVLIAPSSASKEKTQGHIRELEEEVQLLKNLSH 130 Query: 2245 PNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGMNCLHT 2424 PNIV ++G V L+I+ E++P GS+ ++ + E I + G+ LH Sbjct: 131 PNIVRYLGTVRESDSLNILMEFVPGGSISSLLEKFG-SFPEPVIIMYTKQLLLGLEYLHN 189 Query: 2425 SVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSR--LKHSTFLSSKSTAGTPEWMAPEVLRN 2598 + I+HRD+K N+LVD+ +++ DFG S+ ++ +T +KS GTP WMAPEV+ Sbjct: 190 N--GIMHRDIKGANILVDNKGCIRLADFGASKKVVELATVNGAKSMKGTPYWMAPEVILQ 247 Query: 2599 EQSNEKCDIYSFGVILWELATLRKPW-HGMNQMQVVGAVGFQDRRLDIPKEVDPIVASII 2775 + DI+S G + E+AT + PW Q V +G IP+++ P + Sbjct: 248 TGHSFSADIWSVGCTVIEMATGKPPWSEQYQQFAAVLHIGRTKAHPPIPEDLSPEAKDFL 307 Query: 2776 RDCWQKDPNLRPSFIQLTSY 2835 C K+P+LR S +L + Sbjct: 308 MKCLHKEPSLRLSATELLQH 327
>P54755:EPHA5_CHICK Ephrin type-A receptor 5 precursor - Gallus gallus (Chicken)| Length = 1013 Score = 123 bits (309), Expect = 4e-27 Identities = 89/279 (31%), Positives = 136/279 (48%), Gaps = 9/279 (3%) Frame = +1 Query: 2080 LVIDERIGIGSYGEVYHADWN-----GTEVAVKKFLDQEFYGDALEEFRCEVRIMRRLRH 2244 + I+ IG G +GEV VA+K L + +F E IM + H Sbjct: 651 ITIERVIGAGEFGEVCSGRLKLQGKREFPVAIKT-LKVGYTEKQRRDFLGEASIMGQFDH 709 Query: 2245 PNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGMNCLHT 2424 PNI+ G VT+ + IV+EY+ GSL + + + Q + + M +A GM L Sbjct: 710 PNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRGIASGMKYL-- 767 Query: 2425 SVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAGTP---EWMAPEVLR 2595 S VHRDL + N+L++ N KV DFGLSR+ ++ +T G W APE + Sbjct: 768 SDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAIA 827 Query: 2596 NEQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVASI 2772 + D++S+G+++WE+ + +P+ M V+ AV + RL P + + + Sbjct: 828 FRKFTSASDVWSYGIVMWEVMSYGERPYWEMTNQDVIKAVE-EGYRLPSPMDCPAALYQL 886 Query: 2773 IRDCWQKDPNLRPSFIQLTSYLKTLQRLVIPSHQETASN 2889 + DCWQKD N RP F ++ S L L R PS +T N Sbjct: 887 MLDCWQKDRNSRPKFDEIVSMLDKLIR--NPSSLKTLVN 923
>P42680:TEC_HUMAN Tyrosine-protein kinase Tec - Homo sapiens (Human)| Length = 631 Score = 123 bits (308), Expect = 6e-27 Identities = 87/269 (32%), Positives = 130/269 (48%), Gaps = 3/269 (1%) Frame = +1 Query: 2062 EILWEDLVIDERIGIGSYGEVYHADWNGT-EVAVKKFLDQEFYGDALEEFRCEVRIMRRL 2238 EI +L +G G +G V W +VA+K + E+F E ++M +L Sbjct: 364 EINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAM---CEEDFIEEAKVMMKL 420 Query: 2239 RHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGMNCL 2418 HP +V G T+ + IV+E++ RG L + + + M DV GM L Sbjct: 421 THPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSRDVLLSMCQDVCEGMEYL 480 Query: 2419 HTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAGTP-EWMAPEVLR 2595 + + +HRDL + N LV + VKV DFG++R +S S A P +W PEV Sbjct: 481 ERN--SFIHRDLAARNCLVSEAGVVKVSDFGMARYFLDDQYTSSSGAKFPVKWCPPEVFN 538 Query: 2596 NEQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVASI 2772 + + K D++SFGV++WE+ T R P+ +VV V + RL PK V + Sbjct: 539 YSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMV-TRGHRLYQPKLASNYVYEV 597 Query: 2773 IRDCWQKDPNLRPSFIQLTSYLKTLQRLV 2859 + CWQ+ P RPSF L L+T+ LV Sbjct: 598 MLRCWQEKPEGRPSFEDL---LRTIDELV 623
>P18106:FPS_DROME Tyrosine-protein kinase Fps85D - Drosophila melanogaster (Fruit fly)| Length = 1325 Score = 123 bits (308), Expect = 6e-27 Identities = 81/277 (29%), Positives = 135/277 (48%), Gaps = 6/277 (2%) Frame = +1 Query: 2059 CEILWE----DLVIDERIGIGSYGEVYHADWNGTEVAVK-KFLDQEFYGDALEEFRCEVR 2223 C WE D+V+ ERIG G++G+VY A T++ V K + +F E R Sbjct: 1052 CRERWELSNDDVVLLERIGRGNFGDVYKAKLKSTKLDVAVKTCRMTLPDEQKRKFLQEGR 1111 Query: 2224 IMRRLRHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVAR 2403 I+++ HPNIV +G + + IV E + GSL + + + + ++++ M D A Sbjct: 1112 ILKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSNGLTTRQQMGMCRDAAA 1171 Query: 2404 GMNCLHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAGTPEWMAP 2583 GM L + +HRDL + N LVD +VK+ DFG+SR + +S +W AP Sbjct: 1172 GMRYLESK--NCIHRDLAARNCLVDLEHSVKISDFGMSREEEEYIVSDGMKQIPVKWTAP 1229 Query: 2584 EVLRNEQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPI 2760 E L + CD++S+G+++WE+ + P+ GM + + R+ PK Sbjct: 1230 EALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERID-TGYRMPTPKSTPEE 1288 Query: 2761 VASIIRDCWQKDPNLRPSFIQLTSYLKTLQRLVIPSH 2871 + ++ CW D RP F ++ + + L + SH Sbjct: 1289 MYRLMLQCWAADAESRPHFDEIYNVVDALILRLDNSH 1325
>P22182:FGFR1_XENLA Fibroblast growth factor receptor 1 precursor - Xenopus laevis| (African clawed frog) Length = 812 Score = 123 bits (308), Expect = 6e-27 Identities = 95/314 (30%), Positives = 158/314 (50%), Gaps = 28/314 (8%) Frame = +1 Query: 2041 LDEVSECEILWEDLVIDERIGIGSYGEVYHADWNG---------TEVAVKKFLDQEFYGD 2193 L E E+ + L++ + +G G +G+V A+ G T+VAVK D Sbjct: 459 LPEDPRWEVARDRLILGKPLGEGCFGQVVMAEAIGLDKEKPNKVTKVAVKMLKSDASEKD 518 Query: 2194 ALEEFRCEVRIMRRL-RHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKII---------- 2340 L + E+ +M+ + +H NI+ +GA T+ L ++ EY +G+L + + Sbjct: 519 -LSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYTSKGNLREYLRARRPPAMEY 577 Query: 2341 -HRPNCQIDE----KRRIKMALDVARGMNCLHTSVPTIVHRDLKSPNLLVDDNWTVKVCD 2505 + P C D+ K + A VARGM+ L + +HRDL + N+LV ++ +K+ D Sbjct: 578 CYNPTCVPDQLLSFKDLVSCAYQVARGMDYLASK--KCIHRDLAARNVLVTEDNIMKIAD 635 Query: 2506 FGLSRLKHSTFLSSKSTAGT--PEWMAPEVLRNEQSNEKCDIYSFGVILWELATL-RKPW 2676 FGL+R H K+T G +WMAPE L + + D++SFGV+LWE+ TL P+ Sbjct: 636 FGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPY 695 Query: 2677 HGMNQMQVVGAVGFQDRRLDIPKEVDPIVASIIRDCWQKDPNLRPSFIQLTSYLKTLQRL 2856 G+ M+ + + + R+D P + +++DCW P+ RP+F QL L + L Sbjct: 696 PGV-PMEELFKLLKEGHRMDKPTNCTNELYMMMKDCWHAMPSQRPTFNQLVEDLDRI--L 752 Query: 2857 VIPSHQETASNHVP 2898 + S+QE +P Sbjct: 753 ALSSNQEYLDLSMP 766
>Q07498:EPHB3_CHICK Ephrin type-B receptor 3 - Gallus gallus (Chicken)| Length = 988 Score = 123 bits (308), Expect = 6e-27 Identities = 85/266 (31%), Positives = 129/266 (48%), Gaps = 10/266 (3%) Frame = +1 Query: 2086 IDERIGIGSYGEVYHADWN---GTEVAVK-KFLDQEFYGDALEEFRCEVRIMRRLRHPNI 2253 I+E IG G +GEV E+ V K L + +F E IM + HPNI Sbjct: 625 IEEVIGAGEFGEVCRGRLKLPGRREIFVAIKTLKVGYTERQRRDFLSEASIMGQFDHPNI 684 Query: 2254 VLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGMNCLHTSVP 2433 + G VT+ + I++E++ +L + + Q + + M +A GM L S Sbjct: 685 IHLEGVVTKSRPVMIITEFMENCALDSFLRLNDGQFTVIQLVGMLRGIAAGMKYL--SEM 742 Query: 2434 TIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHS-----TFLSSKSTAGTPEWMAPEVLRN 2598 VHRDL + N+LV+ N KV DFGLSR T+ SS W APE + Sbjct: 743 NYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPADPTYTSSLGGKIPIRWTAPEAIAY 802 Query: 2599 EQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVASII 2775 + D++S+G+++WE+ + +P+ M+ V+ AV QD RL P + + ++ Sbjct: 803 RKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVINAVE-QDYRLPPPMDCPTALHQLM 861 Query: 2776 RDCWQKDPNLRPSFIQLTSYLKTLQR 2853 DCW +D NLRP F Q+ + L L R Sbjct: 862 LDCWVRDRNLRPKFAQIVNTLDKLIR 887
>Q60629:EPHA5_MOUSE Ephrin type-A receptor 5 precursor - Mus musculus (Mouse)| Length = 877 Score = 123 bits (308), Expect = 6e-27 Identities = 88/279 (31%), Positives = 136/279 (48%), Gaps = 9/279 (3%) Frame = +1 Query: 2080 LVIDERIGIGSYGEVYHA-----DWNGTEVAVKKFLDQEFYGDALEEFRCEVRIMRRLRH 2244 + I+ IG G +GEV VA+K L + +F E IM + H Sbjct: 514 ITIERVIGAGEFGEVCSGCLKLPGKRELPVAIKT-LKVGYTEKQRRDFLGEASIMGQFDH 572 Query: 2245 PNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGMNCLHT 2424 PNI+ G VT+ + IV+EY+ GSL + + + Q + + M +A GM L Sbjct: 573 PNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRGIAAGMKYL-- 630 Query: 2425 SVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAGTP---EWMAPEVLR 2595 S VHRDL + N+L++ N KV DFGLSR+ ++ +T G W APE + Sbjct: 631 SDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAIA 690 Query: 2596 NEQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVASI 2772 + D++S+G+++WE+ + +P+ M V+ AV + RL P + + + Sbjct: 691 FRKFTSASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVE-EGYRLPSPMDCPAALYQL 749 Query: 2773 IRDCWQKDPNLRPSFIQLTSYLKTLQRLVIPSHQETASN 2889 + DCWQKD N RP F ++ + L L R PS +T N Sbjct: 750 MLDCWQKDRNSRPKFDEIVNMLDKLIR--NPSSLKTLVN 786
>Q02763:TIE2_HUMAN Angiopoietin-1 receptor precursor - Homo sapiens (Human)| Length = 1124 Score = 122 bits (307), Expect = 7e-27 Identities = 94/305 (30%), Positives = 149/305 (48%), Gaps = 23/305 (7%) Frame = +1 Query: 2071 WEDLVIDERIGIGSYGEVYHA----DWNGTEVAVKKFLDQEFYGDALEEFRCEVRIMRRL 2238 W D+ + IG G++G+V A D + A+K+ + D +F E+ ++ +L Sbjct: 821 WNDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDH-RDFAGELEVLCKL 879 Query: 2239 -RHPNIVLFMGAVTRPPHLSIVSEYLPRGSL---------------YKIIHRPNCQIDEK 2370 HPNI+ +GA +L + EY P G+L + I + + + Sbjct: 880 GHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQ 939 Query: 2371 RRIKMALDVARGMNCLHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSK 2550 + + A DVARGM+ L S +HRDL + N+LV +N+ K+ DFGLSR + + K Sbjct: 940 QLLHFAADVARGMDYL--SQKQFIHRDLAARNILVGENYVAKIADFGLSRGQE---VYVK 994 Query: 2551 STAG--TPEWMAPEVLRNEQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQ 2721 T G WMA E L D++S+GV+LWE+ +L P+ GM ++ + Q Sbjct: 995 KTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLP-Q 1053 Query: 2722 DRRLDIPKEVDPIVASIIRDCWQKDPNLRPSFIQLTSYLKTLQRLVIPSHQETASNHVPY 2901 RL+ P D V ++R CW++ P RPSF Q+ L +L R++ ++T N Y Sbjct: 1054 GYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQI---LVSLNRML--EERKTYVNTTLY 1108 Query: 2902 EISLY 2916 E Y Sbjct: 1109 EKFTY 1113
>Q06807:TIE2_BOVIN Angiopoietin-1 receptor precursor - Bos taurus (Bovine)| Length = 1125 Score = 122 bits (307), Expect = 7e-27 Identities = 94/305 (30%), Positives = 149/305 (48%), Gaps = 23/305 (7%) Frame = +1 Query: 2071 WEDLVIDERIGIGSYGEVYHA----DWNGTEVAVKKFLDQEFYGDALEEFRCEVRIMRRL 2238 W D+ + IG G++G+V A D + A+K+ + D +F E+ ++ +L Sbjct: 822 WNDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDH-RDFAGELEVLCKL 880 Query: 2239 -RHPNIVLFMGAVTRPPHLSIVSEYLPRGSL---------------YKIIHRPNCQIDEK 2370 HPNI+ +GA +L + EY P G+L + I + + + Sbjct: 881 GHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQ 940 Query: 2371 RRIKMALDVARGMNCLHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSK 2550 + + A DVARGM+ L S +HRDL + N+LV +N+ K+ DFGLSR + + K Sbjct: 941 QLLHFAADVARGMDYL--SQKQFIHRDLAARNILVGENYVAKIADFGLSRGQE---VYVK 995 Query: 2551 STAG--TPEWMAPEVLRNEQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQ 2721 T G WMA E L D++S+GV+LWE+ +L P+ GM ++ + Q Sbjct: 996 KTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLP-Q 1054 Query: 2722 DRRLDIPKEVDPIVASIIRDCWQKDPNLRPSFIQLTSYLKTLQRLVIPSHQETASNHVPY 2901 RL+ P D V ++R CW++ P RPSF Q+ L +L R++ ++T N Y Sbjct: 1055 GYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQI---LVSLNRML--EERKTYVNTTLY 1109 Query: 2902 EISLY 2916 E Y Sbjct: 1110 EKFTY 1114
>P24604:TEC_MOUSE Tyrosine-protein kinase Tec - Mus musculus (Mouse)| Length = 630 Score = 122 bits (307), Expect = 7e-27 Identities = 100/338 (29%), Positives = 151/338 (44%), Gaps = 4/338 (1%) Frame = +1 Query: 1858 KNAQGFTPERDE-HKENCGSYDHRMLHPDPRKSPLDRFMDRPRQNIECVSPSQVGSSKVD 2034 K+A G PE E HK N R+ +P K +P+ G S Sbjct: 316 KHAFGSIPEIIEYHKHNAAGLVTRLRYPVSTKGKN--------------APTTAGFS--- 358 Query: 2035 LVLDEVSECEILWEDLVIDERIGIGSYGEVYHADWNGT-EVAVKKFLDQEFYGDALEEFR 2211 + EI +L +G G +G V W +VA+K + E+F Sbjct: 359 -----YDKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAM---CEEDFI 410 Query: 2212 CEVRIMRRLRHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMAL 2391 E ++M +L HP +V G T+ + IV+E++ RG L + + + M Sbjct: 411 EEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSRDMLLSMCQ 470 Query: 2392 DVARGMNCLHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAGTP- 2568 DV GM L + + +HRDL + N LV++ VKV DFG++R +S S A P Sbjct: 471 DVCEGMEYLERN--SFIHRDLAARNCLVNEAGVVKVSDFGMARYVLDDQYTSSSGAKFPV 528 Query: 2569 EWMAPEVLRNEQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPK 2745 +W PEV + + K D++SFGV++WE+ T R P+ +VV V + RL PK Sbjct: 529 KWCPPEVFNYSRFSSKSDVWSFGVLMWEIFTEGRMPFEKNTNYEVVTMV-TRGHRLHRPK 587 Query: 2746 EVDPIVASIIRDCWQKDPNLRPSFIQLTSYLKTLQRLV 2859 + ++ CWQ+ P RPS L L+T+ LV Sbjct: 588 LATKYLYEVMLRCWQERPEGRPS---LEDLLRTIDELV 622
>P09769:FGR_HUMAN Proto-oncogene tyrosine-protein kinase FGR - Homo sapiens (Human)| Length = 529 Score = 122 bits (307), Expect = 7e-27 Identities = 87/275 (31%), Positives = 137/275 (49%), Gaps = 4/275 (1%) Frame = +1 Query: 2062 EILWEDLVIDERIGIGSYGEVYHADWNG-TEVAVKKFLDQEFYGDALEEFRCEVRIMRRL 2238 EI + ++ R+G G +G+V+ WNG T+VAVK A E E ++M+ L Sbjct: 257 EISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLE---EAQVMKLL 313 Query: 2239 RHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQ-IDEKRRIKMALDVARGMNC 2415 RH +V V+ P + IV+E++ GSL + P Q + + + MA VA GM Sbjct: 314 RHDKLVQLYAVVSEEP-IYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAY 372 Query: 2416 LHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRL-KHSTFLSSKSTAGTPEWMAPEVL 2592 + +HRDL++ N+LV + K+ DFGL+RL K + + + +W APE Sbjct: 373 MERM--NYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAA 430 Query: 2593 RNEQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVAS 2769 + K D++SFG++L EL T R P+ GMN+ +V+ V Q + P + Sbjct: 431 LFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVE-QGYHMPCPPGCPASLYE 489 Query: 2770 IIRDCWQKDPNLRPSFIQLTSYLKTLQRLVIPSHQ 2874 + W+ DP RP+F L S+L+ P +Q Sbjct: 490 AMEQTWRLDPEERPTFEYLQSFLEDYFTSAEPQYQ 524
>P54754:EPHB3_MOUSE Ephrin type-B receptor 3 precursor - Mus musculus (Mouse)| Length = 993 Score = 122 bits (307), Expect = 7e-27 Identities = 86/266 (32%), Positives = 129/266 (48%), Gaps = 10/266 (3%) Frame = +1 Query: 2086 IDERIGIGSYGEVYHADWN---GTEVAVK-KFLDQEFYGDALEEFRCEVRIMRRLRHPNI 2253 I+E IG G +GEV EV V K L + +F E IM + HPNI Sbjct: 630 IEEVIGAGEFGEVCRGRLKLPGRREVFVAIKTLKVGYTERQRRDFLSEASIMGQFDHPNI 689 Query: 2254 VLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGMNCLHTSVP 2433 + G VT+ + I++E++ +L + + Q + + M +A GM L S Sbjct: 690 IRLEGVVTKSRPVMILTEFMENCALDSFLRLNDGQFTVIQLVGMLRGIAAGMKYL--SEM 747 Query: 2434 TIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHS-----TFLSSKSTAGTPEWMAPEVLRN 2598 VHRDL + N+LV+ N KV DFGLSR T+ SS W APE + Sbjct: 748 NYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIRWTAPEAIAY 807 Query: 2599 EQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVASII 2775 + D++S+G+++WE+ + +P+ M+ V+ AV QD RL P + + ++ Sbjct: 808 RKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVINAVE-QDYRLPPPMDCPTALHQLM 866 Query: 2776 RDCWQKDPNLRPSFIQLTSYLKTLQR 2853 DCW +D NLRP F Q+ + L L R Sbjct: 867 LDCWVRDRNLRPKFSQIVNTLDKLIR 892
>P54753:EPHB3_HUMAN Ephrin type-B receptor 3 precursor - Homo sapiens (Human)| Length = 998 Score = 122 bits (307), Expect = 7e-27 Identities = 86/266 (32%), Positives = 129/266 (48%), Gaps = 10/266 (3%) Frame = +1 Query: 2086 IDERIGIGSYGEVYHADWNGT---EVAVK-KFLDQEFYGDALEEFRCEVRIMRRLRHPNI 2253 I+E IG G +GEV EV V K L + +F E IM + HPNI Sbjct: 635 IEEVIGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGYTERQRRDFLSEASIMGQFDHPNI 694 Query: 2254 VLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGMNCLHTSVP 2433 + G VT+ + I++E++ +L + + Q + + M +A GM L S Sbjct: 695 IRLEGVVTKSRPVMILTEFMENCALDSFLRLNDGQFTVIQLVGMLRGIAAGMKYL--SEM 752 Query: 2434 TIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHS-----TFLSSKSTAGTPEWMAPEVLRN 2598 VHRDL + N+LV+ N KV DFGLSR T+ SS W APE + Sbjct: 753 NYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIRWTAPEAIAY 812 Query: 2599 EQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVASII 2775 + D++S+G+++WE+ + +P+ M+ V+ AV QD RL P + + ++ Sbjct: 813 RKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVINAVE-QDYRLPPPMDCPTALHQLM 871 Query: 2776 RDCWQKDPNLRPSFIQLTSYLKTLQR 2853 DCW +D NLRP F Q+ + L L R Sbjct: 872 LDCWVRDRNLRPKFSQIVNTLDKLIR 897
>P54757:EPHA5_RAT Ephrin type-A receptor 5 precursor - Rattus norvegicus (Rat)| Length = 1005 Score = 122 bits (307), Expect = 7e-27 Identities = 88/278 (31%), Positives = 135/278 (48%), Gaps = 8/278 (2%) Frame = +1 Query: 2080 LVIDERIGIGSYGEVYHADWN---GTEVAVK-KFLDQEFYGDALEEFRCEVRIMRRLRHP 2247 + I+ IG G +GEV E+ V K L + +F E IM + HP Sbjct: 677 ITIERVIGAGEFGEVCSGRLKLPGKRELPVATKTLKVGYTEKQRRDFLSEASIMGQFDHP 736 Query: 2248 NIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGMNCLHTS 2427 NI+ G VT+ + IV+EY+ GSL + + + Q + + M +A GM L S Sbjct: 737 NIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRGIAAGMKYL--S 794 Query: 2428 VPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAGTP---EWMAPEVLRN 2598 VHRDL + N+L++ N KV DFGLSR+ ++ +T G W APE + Sbjct: 795 DMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAF 854 Query: 2599 EQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVASII 2775 + D++S+G+++WE+ + +P+ M V+ AV + RL P + + ++ Sbjct: 855 RKFTSASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVE-EGYRLPSPMDCPAALYQLM 913 Query: 2776 RDCWQKDPNLRPSFIQLTSYLKTLQRLVIPSHQETASN 2889 DCWQKD N RP F + + L L R PS +T N Sbjct: 914 LDCWQKDRNSRPKFDDIVNMLDKLIR--NPSSLKTLVN 949
>Q9ZWC8:BRL1_ARATH Serine/threonine-protein kinase BRI1-like 1 precursor - Arabidopsis| thaliana (Mouse-ear cress) Length = 1166 Score = 122 bits (307), Expect = 7e-27 Identities = 74/201 (36%), Positives = 120/201 (59%), Gaps = 9/201 (4%) Frame = +1 Query: 2098 IGIGSYGEVYHADW-NGTEVAVKKFLDQEFYGDALEEFRCEVRIMRRLRHPNIVLFMGAV 2274 +G G +GEVY A +G+ VA+KK + GD EF E+ + +++H N+V +G Sbjct: 865 VGSGGFGEVYKAQLRDGSVVAIKKLIRITGQGD--REFMAEMETIGKIKHRNLVPLLGYC 922 Query: 2275 TRPPHLSIVSEYLPRGSLYKIIHRPNCQ-----IDEKRRIKMALDVARGMNCLHTS-VPT 2436 +V EY+ GSL ++H + + ++ R K+A+ ARG+ LH S +P Sbjct: 923 KVGEERLLVYEYMKWGSLETVLHEKSSKKGGIYLNWAARKKIAIGAARGLAFLHHSCIPH 982 Query: 2437 IVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHS--TFLSSKSTAGTPEWMAPEVLRNEQSN 2610 I+HRD+KS N+L+D+++ +V DFG++RL + T LS + AGTP ++ PE ++ + Sbjct: 983 IIHRDMKSSNVLLDEDFEARVSDFGMARLVSALDTHLSVSTLAGTPGYVPPEYYQSFRCT 1042 Query: 2611 EKCDIYSFGVILWELATLRKP 2673 K D+YS+GVIL EL + +KP Sbjct: 1043 AKGDVYSYGVILLELLSGKKP 1063
>Q02858:TIE2_MOUSE Angiopoietin-1 receptor precursor - Mus musculus (Mouse)| Length = 1122 Score = 122 bits (306), Expect = 1e-26 Identities = 94/305 (30%), Positives = 149/305 (48%), Gaps = 23/305 (7%) Frame = +1 Query: 2071 WEDLVIDERIGIGSYGEVYHA----DWNGTEVAVKKFLDQEFYGDALEEFRCEVRIMRRL 2238 W D+ + IG G++G+V A D + A+K+ + D +F E+ ++ +L Sbjct: 819 WNDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDH-RDFAGELEVLCKL 877 Query: 2239 -RHPNIVLFMGAVTRPPHLSIVSEYLPRGSL---------------YKIIHRPNCQIDEK 2370 HPNI+ +GA +L + EY P G+L + I + + + Sbjct: 878 GHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQ 937 Query: 2371 RRIKMALDVARGMNCLHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSK 2550 + + A DVARGM+ L S +HRDL + N+LV +N+ K+ DFGLSR + + K Sbjct: 938 QLLHFAADVARGMDYL--SQKQFIHRDLAARNILVGENYIAKIADFGLSRGQE---VYVK 992 Query: 2551 STAG--TPEWMAPEVLRNEQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQ 2721 T G WMA E L D++S+GV+LWE+ +L P+ GM ++ + Q Sbjct: 993 KTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLP-Q 1051 Query: 2722 DRRLDIPKEVDPIVASIIRDCWQKDPNLRPSFIQLTSYLKTLQRLVIPSHQETASNHVPY 2901 RL+ P D V ++R CW++ P RPSF Q+ L +L R++ ++T N Y Sbjct: 1052 GYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQI---LVSLNRML--EERKTYVNTTLY 1106 Query: 2902 EISLY 2916 E Y Sbjct: 1107 EKFTY 1111
>P07332:FES_HUMAN Proto-oncogene tyrosine-protein kinase Fes/Fps - Homo sapiens (Human)| Length = 822 Score = 122 bits (306), Expect = 1e-26 Identities = 82/265 (30%), Positives = 135/265 (50%), Gaps = 5/265 (1%) Frame = +1 Query: 2074 EDLVIDERIGIGSYGEVYHADW--NGTEVAVKKFLDQEFYGDALEEFRCEVRIMRRLRHP 2247 EDLV+ E+IG G++GEV+ + T VAVK + D +F E RI+++ HP Sbjct: 559 EDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKS-CRETLPPDLKAKFLQEARILKQYSHP 617 Query: 2248 NIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGMNCLHTS 2427 NIV +G T+ + IV E + G + ++ K ++M D A GM L + Sbjct: 618 NIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESK 677 Query: 2428 VPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLK-HSTFLSSKSTAGTP-EWMAPEVLRNE 2601 +HRDL + N LV + +K+ DFG+SR + + +S P +W APE L Sbjct: 678 --CCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYG 735 Query: 2602 QSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVASIIR 2778 + + + D++SFG++LWE +L P+ ++ Q V + RL P+ V ++ Sbjct: 736 RYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVE-KGGRLPCPELCPDAVFRLME 794 Query: 2779 DCWQKDPNLRPSFIQLTSYLKTLQR 2853 CW +P RPSF + L+++++ Sbjct: 795 QCWAYEPGQRPSFSTIYQELQSIRK 819
>Q61161:M4K2_MOUSE Mitogen-activated protein kinase kinase kinase kinase 2 - Mus| musculus (Mouse) Length = 821 Score = 122 bits (305), Expect = 1e-26 Identities = 82/262 (31%), Positives = 134/262 (51%), Gaps = 7/262 (2%) Frame = +1 Query: 2092 ERIGIGSYGEVYHA-DWNGTEVAVKKFLDQEFYGDALEEFRCEVRIMRRLRHPNIVLFMG 2268 +R+G G+YG+VY A D +E+A K + + GD + + E+ I+R RHPN+V ++G Sbjct: 20 QRVGAGTYGDVYKARDTVTSELAAVKIVKLD-PGDDISSLQQEITILRECRHPNVVAYIG 78 Query: 2269 AVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGMNCLHTSVPTIVHR 2448 + R L I E+ GSL +I H ++E++ + + +G++ LH+ +HR Sbjct: 79 SYLRNDRLWICMEFCGGGSLQEIYHATG-PLEERQIAYVCREALKGLHHLHSQGK--IHR 135 Query: 2449 DLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAGTPEWMAPEVLRNEQS---NEKC 2619 D+K NLL+ VK+ DFG+S ++ +S GTP WMAPEV E+ NE C Sbjct: 136 DIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWMAPEVAAVERKGGYNELC 195 Query: 2620 DIYSFGVILWELATLRKP---WHGMNQMQVVGAVGFQDRRLDIPKEVDPIVASIIRDCWQ 2790 D+++ G+ EL L+ P H M + ++ FQ +L ++ Sbjct: 196 DVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKLRDKTRWTQNFHHFLKLALT 255 Query: 2791 KDPNLRPSFIQLTSYLKTLQRL 2856 K+P RP+ +L + T Q L Sbjct: 256 KNPKKRPTAERLLQHPFTTQHL 277
>O65468:CRK8_ARATH Cysteine-rich receptor-like protein kinase 8 precursor - Arabidopsis| thaliana (Mouse-ear cress) Length = 676 Score = 122 bits (305), Expect = 1e-26 Identities = 99/321 (30%), Positives = 160/321 (49%), Gaps = 30/321 (9%) Frame = +1 Query: 1975 RPRQNIECVSPSQVGS--SKVDLVLDEVSECEILWEDLVIDERIGIGSYGEVYHADW-NG 2145 R ++ + S S+VG + D + + + D +IG G +GEVY + NG Sbjct: 316 RTKKTFDTASASEVGDDMATADSLQLDYRTIQTATNDFAESNKIGRGGFGEVYKGTFSNG 375 Query: 2146 TEVAVKKFLDQEFYGDALEEFRCEVRIMRRLRHPNIVLFMGAVTRPPHLSIVSEYLPRGS 2325 EVAVK+ G+A EF+ EV ++ +L+H N+V +G + +V EY+P S Sbjct: 376 KEVAVKRLSKNSRQGEA--EFKTEVVVVAKLQHRNLVRLLGFSLQGEERILVYEYMPNKS 433 Query: 2326 LYKIIHRPN--CQIDEKRRIKMALDVARGMNCLHT-SVPTIVHRDLKSPNLLVDDNWTVK 2496 L ++ P Q+D +R + +ARG+ LH S TI+HRDLK+ N+L+D + K Sbjct: 434 LDCLLFDPTKQTQLDWMQRYNIIGGIARGILYLHQDSRLTIIHRDLKASNILLDADINPK 493 Query: 2497 VCDFGLSRL--KHSTFLSSKSTAGTPEWMAPEVLRNEQSNEKCDIYSFGVILWELATLRK 2670 + DFG++R+ T ++ GT +MAPE + Q + K D+YSFGV++ E+ + RK Sbjct: 494 IADFGMARIFGLDQTQDNTSRIVGTYGYMAPEYAMHGQFSMKSDVYSFGVLVLEIISGRK 553 Query: 2671 PWH------GMNQMQVVGAVGFQDRRLDIPKEVDPIVASIIRD------------CWQKD 2796 + + + LD+ VDP++A+ ++ C Q+D Sbjct: 554 NSSFDESDGAQDLLTHTWRLWTNRTALDL---VDPLIANNCQNSEVVRCIHIGLLCVQED 610 Query: 2797 PNLRPS----FIQLTSYLKTL 2847 P RP+ F+ LTS TL Sbjct: 611 PAKRPTISTVFMMLTSNTVTL 631
>Q9C5S9:CRK6_ARATH Cysteine-rich receptor-like protein kinase 6 precursor - Arabidopsis| thaliana (Mouse-ear cress) Length = 674 Score = 122 bits (305), Expect = 1e-26 Identities = 99/321 (30%), Positives = 160/321 (49%), Gaps = 30/321 (9%) Frame = +1 Query: 1975 RPRQNIECVSPSQVGS--SKVDLVLDEVSECEILWEDLVIDERIGIGSYGEVYHADW-NG 2145 + ++ + S S+VG + D + + + D +IG G +GEVY + NG Sbjct: 314 KKKKTFDTASASEVGDDMATADSLQLDYRTIQTATNDFAESNKIGRGGFGEVYKGTFSNG 373 Query: 2146 TEVAVKKFLDQEFYGDALEEFRCEVRIMRRLRHPNIVLFMGAVTRPPHLSIVSEYLPRGS 2325 EVAVK+ G+A EF+ EV ++ +L+H N+V +G + +V EY+P S Sbjct: 374 KEVAVKRLSKNSRQGEA--EFKTEVVVVAKLQHRNLVRLLGFSLQGEERILVYEYMPNKS 431 Query: 2326 LYKIIHRPNCQI--DEKRRIKMALDVARGMNCLHT-SVPTIVHRDLKSPNLLVDDNWTVK 2496 L ++ P QI D +R + +ARG+ LH S TI+HRDLK+ N+L+D + K Sbjct: 432 LDCLLFDPTKQIQLDWMQRYNIIGGIARGILYLHQDSRLTIIHRDLKASNILLDADINPK 491 Query: 2497 VCDFGLSRL--KHSTFLSSKSTAGTPEWMAPEVLRNEQSNEKCDIYSFGVILWELATLRK 2670 + DFG++R+ T ++ GT +MAPE + Q + K D+YSFGV++ E+ + RK Sbjct: 492 IADFGMARIFGLDQTQDNTSRIVGTYGYMAPEYAMHGQFSMKSDVYSFGVLVLEIISGRK 551 Query: 2671 PWH------GMNQMQVVGAVGFQDRRLDIPKEVDPIVASIIRD------------CWQKD 2796 + + + + LD+ VDP++A ++ C Q+D Sbjct: 552 NSSFGESDGAQDLLTHAWRLWTNKKALDL---VDPLIAENCQNSEVVRCIHIGLLCVQED 608 Query: 2797 PNLRPS----FIQLTSYLKTL 2847 P RP+ F+ LTS TL Sbjct: 609 PAKRPAISTVFMMLTSNTVTL 629
>O02742:ACK2_BOVIN Activated CDC42 kinase 2 - Bos taurus (Bovine)| Length = 747 Score = 122 bits (305), Expect = 1e-26 Identities = 84/274 (30%), Positives = 131/274 (47%), Gaps = 10/274 (3%) Frame = +1 Query: 2059 CEILWEDLVIDERIGIGSYGEVYHADWNG-----TEVAVKKFL-DQEFYGDALEEFRCEV 2220 C I +DL + E++G GS+G V +W+ VAVK D +A+++F EV Sbjct: 119 CLIGEKDLHLFEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREV 178 Query: 2221 RIMRRLRHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVA 2400 M L H N++ G V PP + +V+E P GSL + + + A+ VA Sbjct: 179 NAMHSLDHRNLIRLYGVVLTPP-MKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVA 237 Query: 2401 RGMNCLHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRL---KHSTFLSSKSTAGTPE 2571 GM L +HRDL + NLL+ VK+ DFGL R ++ + Sbjct: 238 EGMGYLEAK--RFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFA 295 Query: 2572 WMAPEVLRNEQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKE 2748 W APE L+ + D + FGV LWE+ T ++PW G+N Q++ + + RL P++ Sbjct: 296 WCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPED 355 Query: 2749 VDPIVASIIRDCWQKDPNLRPSFIQLTSYLKTLQ 2850 + +++ CW P RP+F+ L +L Q Sbjct: 356 CPQDIYNVMVQCWAHKPEDRPTFVALRDFLLEAQ 389
>Q07912:ACK1_HUMAN Activated CDC42 kinase 1 - Homo sapiens (Human)| Length = 1036 Score = 122 bits (305), Expect = 1e-26 Identities = 84/274 (30%), Positives = 132/274 (48%), Gaps = 10/274 (3%) Frame = +1 Query: 2059 CEILWEDLVIDERIGIGSYGEVYHADWNG-----TEVAVKKFL-DQEFYGDALEEFRCEV 2220 C I +DL + E++G GS+G V +W+ VAVK D +A+++F EV Sbjct: 119 CLIGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREV 178 Query: 2221 RIMRRLRHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVA 2400 M L H N++ G V PP + +V+E P GSL + + + A+ VA Sbjct: 179 NAMHSLDHRNLIRLYGVVLTPP-MKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVA 237 Query: 2401 RGMNCLHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRL---KHSTFLSSKSTAGTPE 2571 GM L + +HRDL + NLL+ VK+ DFGL R ++ + Sbjct: 238 EGMGYLESK--RFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFA 295 Query: 2572 WMAPEVLRNEQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKE 2748 W APE L+ + D + FGV LWE+ T ++PW G+N Q++ + + RL P++ Sbjct: 296 WCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPED 355 Query: 2749 VDPIVASIIRDCWQKDPNLRPSFIQLTSYLKTLQ 2850 + +++ CW P RP+F+ L +L Q Sbjct: 356 CPQDIYNVMVQCWAHKPEDRPTFVALRDFLLEAQ 389
>Q6VAB6:KSR2_HUMAN Kinase suppressor of Ras 2 - Homo sapiens (Human)| Length = 950 Score = 121 bits (304), Expect = 2e-26 Identities = 91/302 (30%), Positives = 147/302 (48%), Gaps = 28/302 (9%) Frame = +1 Query: 2050 VSECEILWEDLVIDERIGIGSYGEVYHADWNGTEVAVKKFLDQEFYGDALEEFRCEVRIM 2229 + E +I +E L I E IG G +G+VYH W+G EVA++ + D L+ F+ EV Sbjct: 656 LQEWDIPFEQLEIGELIGKGRFGQVYHGRWHG-EVAIRLIDIERDNEDQLKAFKREVMAY 714 Query: 2230 RRLRHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGM 2409 R+ RH N+VLFMGA PPHL+I++ +LY ++ +D + ++A ++ +GM Sbjct: 715 RQTRHENVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGM 774 Query: 2410 NCLHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAGTPE------ 2571 LH I+H+DLKS N+ DN V + DFGL +S AG E Sbjct: 775 GYLHAK--GILHKDLKSKNVFY-DNGKVVITDFGLFS------ISGVLQAGRREDKLRIQ 825 Query: 2572 --W---MAPEVLRNEQS---------NEKCDIYSFGVILWELATLRKPWHGMNQMQVVGA 2709 W +APE++R ++ D+++ G I +EL P+ ++ Sbjct: 826 NGWLCHLAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFKTQPAEAIIWQ 885 Query: 2710 VGFQDR----RLDIPKEVDPIVASIIRDCWQKDPNLRPSFIQLTSYLKTL----QRLVIP 2865 +G + ++ + KE ++ I+ CW + RP+F +L L+ L +RL P Sbjct: 886 MGTGMKPNLSQIGMGKE----ISDILLFCWAFEQEERPTFTKLMDMLEKLPKRNRRLSHP 941 Query: 2866 SH 2871 H Sbjct: 942 GH 943
>Q91285:FGFR1_PLEWA Fibroblast growth factor receptor 1 precursor - Pleurodeles waltlii| (Iberian ribbed newt) Length = 816 Score = 121 bits (304), Expect = 2e-26 Identities = 104/339 (30%), Positives = 167/339 (49%), Gaps = 37/339 (10%) Frame = +1 Query: 1999 VSPSQVGSSKVDLVLDEVSECEI----LWE----DLVIDERIGIGSYGEVYHADWNG--- 2145 V PS++ SS + L VSE E+ WE L++ + +G G +G+V + G Sbjct: 440 VRPSRLSSSGSPM-LTGVSEYELPEDPRWEFSRDRLILGKPLGEGCFGQVVMGEAIGLDK 498 Query: 2146 ------TEVAVKKFLDQEFYGDALEEFRCEVRIMRRL-RHPNIVLFMGAVTRPPHLSIVS 2304 T+VAVK D L + E+ +M+ + +H NI+ +GA T+ L ++ Sbjct: 499 EKPNRVTKVAVKMLKSDATEKD-LSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIV 557 Query: 2305 EYLPRGSL---------------YKIIHRPNCQIDEKRRIKMALDVARGMNCLHTSVPTI 2439 EY +G+L Y IH + K + A VARGM L + Sbjct: 558 EYASKGNLREYLRARRPPGMEYCYNPIHVSKDMLSFKDLVSCAYQVARGMEYLASK--KC 615 Query: 2440 VHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAGT--PEWMAPEVLRNEQSNE 2613 +HRDL + N+LV ++ +K+ DFGL+R H K+T G +WMAPE L + Sbjct: 616 IHRDLAARNVLVTEDSVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTH 675 Query: 2614 KCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVASIIRDCWQ 2790 + D++SFGV+LWE+ TL P+ G+ ++ + + R+D P + ++RDCW Sbjct: 676 QSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLK-EGHRMDKPGNCTNELYMMMRDCWH 734 Query: 2791 KDPNLRPSFIQLTSYLKTLQRLV-IPSHQETASNHVPYE 2904 P+ RP+F QL ++ L R+V + S+QE +P + Sbjct: 735 AVPSQRPTFKQL---VEDLDRIVAMTSNQEYLDLSMPVD 770
>Q8MY86:FGFR1_DUGJA Fibroblast growth factor receptor 1 precursor - Dugesia japonica| (Planarian) Length = 854 Score = 121 bits (304), Expect = 2e-26 Identities = 80/286 (27%), Positives = 146/286 (51%), Gaps = 26/286 (9%) Frame = +1 Query: 2059 CEILWED-----LVIDERIGIGSYGEVYHADWNGT-------EVAVKKFLDQEFYGDALE 2202 C+ WE + ++++G G++G VY N +VAVK D +F + Sbjct: 539 CDAKWEFPREKLKITNKKLGEGAFGMVYEGIANDIGNRSNPIKVAVKMMRD-DFSDSNVH 597 Query: 2203 EFRCEVRIMRRL-RHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRI 2379 +F E+ IM+ + RHPN++ +G T+ L ++ E P G+L + N + + ++I Sbjct: 598 DFVKEMEIMKHIGRHPNVIQLLGLCTQKGPLRVIVELAPYGNLRDFVRAKNKKYSKSKKI 657 Query: 2380 ----------KMALDVARGMNCLHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKH 2529 +L +ARGM L + ++VHRDL + N+LV +++ +K+ DFGL+R+ Sbjct: 658 IGNFTSSILCTYSLQIARGMTYLASR--SVVHRDLSARNILVGEHFEMKIADFGLTRIVD 715 Query: 2530 STFLSSKSTAGTPEWMAPEVLRNEQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVG 2706 + +WMAPE L ++ K D++S+G++LWE+ TL P+ + +VV Sbjct: 716 YYYRKKTDGILPVKWMAPEALLEKKYTTKSDVWSYGILLWEIFTLGDSPYSAILPEKVVD 775 Query: 2707 AV--GFQDRRLDIPKEVDPIVASIIRDCWQKDPNLRPSFIQLTSYL 2838 + GFQ+ + P+ + + +++ CW RP+F ++ L Sbjct: 776 LIRKGFQNPK---PELANFEIYRLMQHCWSLSSENRPNFFEIVEIL 818
>P41242:MATK_MOUSE Megakaryocyte-associated tyrosine-protein kinase - Mus musculus| (Mouse) Length = 505 Score = 121 bits (303), Expect = 2e-26 Identities = 80/257 (31%), Positives = 135/257 (52%), Gaps = 2/257 (0%) Frame = +1 Query: 2074 EDLVIDERIGIGSYGEVYHADWNGTEVAVKKFLDQEFYGDALEEFRCEVRIMRRLRHPNI 2253 + L + +IG G +G V ++ G +VAVK + F E +M +L+H N+ Sbjct: 231 QHLTLGAQIGEGEFGAVLQGEYLGQKVAVKNIKCDV----TAQAFLDETAVMTKLQHRNL 286 Query: 2254 VLFMGAVTRPPHLSIVSEYLPRGSLYKIIH-RPNCQIDEKRRIKMALDVARGMNCLHTSV 2430 V +G + L IV E++ +G+L + R + + ++ AL VA GM L + Sbjct: 287 VRLLGVILHHG-LYIVMEHVSKGNLVNFLRTRGRALVSTSQLLQFALHVAEGMEYLESK- 344 Query: 2431 PTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAGTPEWMAPEVLRNEQSN 2610 +VHRDL + N+LV ++ KV DFGL++ + SS+ +W APE L+N + + Sbjct: 345 -KLVHRDLAARNILVSEDLVAKVSDFGLAKAERKGLDSSRLPV---KWTAPEALKNGRFS 400 Query: 2611 EKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVASIIRDCW 2787 K D++SFGV+LWE+ + R P+ M+ +V AV + R++ P V +++ CW Sbjct: 401 SKSDVWSFGVLLWEVFSYGRAPYPKMSLKEVSEAVE-KGYRMEPPDGCPGSVHTLMGSCW 459 Query: 2788 QKDPNLRPSFIQLTSYL 2838 + +P RP F ++ L Sbjct: 460 EAEPARRPPFRKIVEKL 476
>Q12851:M4K2_HUMAN Mitogen-activated protein kinase kinase kinase kinase 2 - Homo| sapiens (Human) Length = 819 Score = 121 bits (303), Expect = 2e-26 Identities = 82/262 (31%), Positives = 135/262 (51%), Gaps = 7/262 (2%) Frame = +1 Query: 2092 ERIGIGSYGEVYHA-DWNGTEVAVKKFLDQEFYGDALEEFRCEVRIMRRLRHPNIVLFMG 2268 +R+G G+YG+VY A D +E+A K + + GD + + E+ I+R RHPN+V ++G Sbjct: 19 QRVGAGTYGDVYKARDTVTSELAAVKIVKLD-PGDDISSLQQEITILRECRHPNVVAYIG 77 Query: 2269 AVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGMNCLHTSVPTIVHR 2448 + R L I E+ GSL +I H ++E++ + + +G++ LH+ +HR Sbjct: 78 SYLRNDRLWICMEFCGGGSLQEIYHATG-PLEERQIAYVCRERLKGLHHLHSQGK--IHR 134 Query: 2449 DLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAGTPEWMAPEVLRNEQS---NEKC 2619 D+K NLL+ VK+ DFG+S ++ +S GTP WMAPEV E+ NE C Sbjct: 135 DIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWMAPEVAAVERKGGYNELC 194 Query: 2620 DIYSFGVILWELATLRKP---WHGMNQMQVVGAVGFQDRRLDIPKEVDPIVASIIRDCWQ 2790 D+++ G+ EL L+ P H M + ++ FQ +L ++ Sbjct: 195 DVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKLRDKTRWTQNFHHFLKLALT 254 Query: 2791 KDPNLRPSFIQLTSYLKTLQRL 2856 K+P RP+ +L + T Q+L Sbjct: 255 KNPKKRPTAEKLLQHPFTTQQL 276
>Q93105:INSR_AEDAE Insulin-like receptor precursor - Aedes aegypti (Yellowfever| mosquito) Length = 1390 Score = 121 bits (303), Expect = 2e-26 Identities = 87/311 (27%), Positives = 153/311 (49%), Gaps = 19/311 (6%) Frame = +1 Query: 1963 RFMDRPRQNIECVSPSQVGSSKVDLVLDEVSECEILWEDLVIDERIGIGSYGEVYHADWN 2142 R+M + + V+P G V +V + E+ ++ E +G GS+G VY Sbjct: 992 RYMSKQIRMYPEVNPDYAG------VQYKVDDWEVERNHIIQLEELGQGSFGMVYKGILT 1045 Query: 2143 G------TEVAVKKFLDQEFYGDALEEFRCEVRIMRRLRHPNIVLFMGAVTRPPHLSIVS 2304 + K +++ + F E +M++ ++V +G V++ ++ Sbjct: 1046 QLRGEKCNQPCAIKTVNESATAREKDSFLLEASVMKQFNTHHVVRLLGVVSQGDPTLVIM 1105 Query: 2305 EYLPRGSLYKII--HRPNCQIDEKRR--------IKMALDVARGMNCLHTSVPTIVHRDL 2454 E + G L + HRP+ ++ R I+MA+++A G+ L S VHRDL Sbjct: 1106 ELMANGDLKSYLRRHRPDYEMRRSIRQPPTLRQIIQMAIEIADGIGVL--SAKKFVHRDL 1163 Query: 2455 KSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAG--TPEWMAPEVLRNEQSNEKCDIY 2628 + N +V D+ TVK+ DFG++R + T K T G WMAPE L++ + D++ Sbjct: 1164 AARNCMVADDMTVKIGDFGMTRDIYETDYYRKGTKGFLPVRWMAPESLKDGIFSSSSDVF 1223 Query: 2629 SFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVASIIRDCWQKDPNL 2805 S+GV+LWE+ATL +P+ G+ QV+ V ++ P+ + +++R CWQ P Sbjct: 1224 SYGVVLWEMATLASQPYQGLTNDQVLRYV-IDGGVMERPENCPDNLYNLMRRCWQHRPTA 1282 Query: 2806 RPSFIQLTSYL 2838 RP+F+++ S L Sbjct: 1283 RPTFMEIISEL 1293
>P18460:FGFR3_CHICK Fibroblast growth factor receptor 3 precursor - Gallus gallus| (Chicken) Length = 806 Score = 121 bits (303), Expect = 2e-26 Identities = 104/331 (31%), Positives = 162/331 (48%), Gaps = 36/331 (10%) Frame = +1 Query: 2020 SSKVDLVLDEVSECEI----LWE----DLVIDERIGIGSYGEVYHADWNGTE-------- 2151 SS +L VSE E+ WE L + + +G G +G+V A+ G + Sbjct: 438 SSSDGPMLANVSELELPPDPKWELARSRLTLGKPLGEGCFGQVVMAEAIGIDKDKPNKAI 497 Query: 2152 -VAVKKFLDQEFYGDALEEFRCEVRIMRRL-RHPNIVLFMGAVTRPPHLSIVSEYLPRGS 2325 VAVK D D L + E+ +M+ + +H NI+ +GA T+ L ++ EY +G+ Sbjct: 498 TVAVKMLKDDATDKD-LSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVLVEYASKGN 556 Query: 2326 L--YKIIHRP--------NCQIDE-----KRRIKMALDVARGMNCLHTSVPTIVHRDLKS 2460 L Y RP C++ E K + A VARGM L + +HRDL + Sbjct: 557 LREYLRARRPPGMDYSFDTCKLPEEQLTFKDLVSCAYQVARGMEYLASQ--KCIHRDLAA 614 Query: 2461 PNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAGT--PEWMAPEVLRNEQSNEKCDIYSF 2634 N+LV ++ +K+ DFGL+R H+ K+T G +WMAPE L + + D++SF Sbjct: 615 RNVLVTEDNVMKIADFGLARDVHNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSF 674 Query: 2635 GVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVASIIRDCWQKDPNLRP 2811 GV+LWE+ TL P+ G+ ++ + + R+D P + I+R+CW P+ RP Sbjct: 675 GVLLWEIFTLGGSPYPGIPVEELFKLLK-EGHRMDKPANCTHDLYMIMRECWHAVPSQRP 733 Query: 2812 SFIQLTSYLKTLQRLVIPSHQETASNHVPYE 2904 +F QL L + L + S E VP+E Sbjct: 734 TFKQLVEDLDRV--LTMTSTDEYLDLSVPFE 762
>O42422:EPHA7_CHICK Ephrin type-A receptor 7 precursor - Gallus gallus (Chicken)| Length = 993 Score = 121 bits (303), Expect = 2e-26 Identities = 83/264 (31%), Positives = 130/264 (49%), Gaps = 8/264 (3%) Frame = +1 Query: 2086 IDERIGIGSYGEVYHADWN---GTEVAVK-KFLDQEFYGDALEEFRCEVRIMRRLRHPNI 2253 I+ IG G +GEV +VAV K L + +F CE IM + HPN+ Sbjct: 630 IERVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTEKQRRDFLCEASIMGQFDHPNV 689 Query: 2254 VLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGMNCLHTSVP 2433 V G VTR + IV EY+ G+L + + + Q + + M +A GM L + Sbjct: 690 VHLEGVVTRGKPVMIVIEYMENGALDAFLRKHDGQFTVIQLVGMLRGIAAGMRYL--ADM 747 Query: 2434 TIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAG---TPEWMAPEVLRNEQ 2604 VHRDL + N+LV+ N KV DFGLSR+ + +T G W APE ++ + Sbjct: 748 GYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPEAIQYRK 807 Query: 2605 SNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVASIIRD 2781 D++S+G+++WE+ + +P+ M+ V+ A+ + RL P + + ++ D Sbjct: 808 FTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIE-EGYRLPAPMDCPAGLHQLMLD 866 Query: 2782 CWQKDPNLRPSFIQLTSYLKTLQR 2853 CWQK+ RP F Q+ L + R Sbjct: 867 CWQKERGERPKFEQIVGILDKMIR 890
>P47735:RLK5_ARATH Receptor-like protein kinase 5 precursor - Arabidopsis thaliana| (Mouse-ear cress) Length = 999 Score = 120 bits (302), Expect = 3e-26 Identities = 81/228 (35%), Positives = 123/228 (53%), Gaps = 19/228 (8%) Frame = +1 Query: 2047 EVSECEILWEDLVIDER--IGIGSYGEVYHADWNGTEVAVKKFL-------DQEFYGDAL 2199 E+++C +DE+ IG GS G+VY + G EV K L D E+ D+L Sbjct: 678 EIADC--------LDEKNVIGFGSSGKVYKVELRGGEVVAVKKLNKSVKGGDDEYSSDSL 729 Query: 2200 EE--FRCEVRIMRRLRHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIH---RPNCQID 2364 F EV + +RH +IV + +V EY+P GSL ++H + + Sbjct: 730 NRDVFAAEVETLGTIRHKSIVRLWCCCSSGDCKLLVYEYMPNGSLADVLHGDRKGGVVLG 789 Query: 2365 EKRRIKMALDVARGMNCLHTS-VPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKH---- 2529 R+++ALD A G++ LH VP IVHRD+KS N+L+D ++ KV DFG++++ Sbjct: 790 WPERLRIALDAAEGLSYLHHDCVPPIVHRDVKSSNILLDSDYGAKVADFGIAKVGQMSGS 849 Query: 2530 STFLSSKSTAGTPEWMAPEVLRNEQSNEKCDIYSFGVILWELATLRKP 2673 T + AG+ ++APE + + NEK DIYSFGV+L EL T ++P Sbjct: 850 KTPEAMSGIAGSCGYIAPEYVYTLRVNEKSDIYSFGVVLLELVTGKQP 897
>Q64434:PTK6_MOUSE Tyrosine-protein kinase 6 - Mus musculus (Mouse)| Length = 451 Score = 120 bits (302), Expect = 3e-26 Identities = 85/268 (31%), Positives = 134/268 (50%), Gaps = 8/268 (2%) Frame = +1 Query: 2074 EDLVIDERIGIGSYGEVYHADWNG-TEVAVKKFLDQEFYGDALEEFRCEVRIMRRLRHPN 2250 E+ + +++G G +GEV+ A W G VAVK F+ E++ M++LRH + Sbjct: 189 EEFTLCKKLGAGYFGEVFEALWKGQVHVAVKVISRDNLLHQ--HTFQAEIQAMKKLRHKH 246 Query: 2251 IVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEK-----RRIKMALDVARGMNC 2415 I+ T + I++E +P+G+L +++ DEK + A VA GM Sbjct: 247 ILSLYAVATAGDPVYIITELMPKGNLLQLLR----DSDEKALPILELVDFASQVAEGMCY 302 Query: 2416 LHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRL-KHSTFLSSKSTAGTPEWMAPEVL 2592 L + +HRDL + N+LV +N KV DFGL+RL K +LS + +W APE L Sbjct: 303 LESQ--NYIHRDLAARNVLVTENNLCKVGDFGLARLVKEDIYLSHEHNVPY-KWTAPEAL 359 Query: 2593 RNEQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVAS 2769 + K D++SFGV+L E+ + + P+ GM+ + V R+ P E P + Sbjct: 360 SRGHYSIKSDVWSFGVLLHEIFSRGQMPYPGMSNHETFLRVD-AGYRMPCPLECPPNIHK 418 Query: 2770 IIRDCWQKDPNLRPSFIQLTSYLKTLQR 2853 ++ CW +DP RP F L L + R Sbjct: 419 LMLSCWSRDPKQRPCFKDLCEKLTGITR 446
>P41243:MATK_RAT Megakaryocyte-associated tyrosine-protein kinase - Rattus norvegicus| (Rat) Length = 467 Score = 120 bits (302), Expect = 3e-26 Identities = 80/257 (31%), Positives = 135/257 (52%), Gaps = 2/257 (0%) Frame = +1 Query: 2074 EDLVIDERIGIGSYGEVYHADWNGTEVAVKKFLDQEFYGDALEEFRCEVRIMRRLRHPNI 2253 + L + +IG G +G V ++ G +VAVK + F E +M +L+H N+ Sbjct: 192 QHLTLGAQIGEGEFGAVLQGEYLGQKVAVKNIKCDV----TAQAFLDETAVMTKLQHRNL 247 Query: 2254 VLFMGAVTRPPHLSIVSEYLPRGSLYKIIH-RPNCQIDEKRRIKMALDVARGMNCLHTSV 2430 V +G + L IV E++ +G+L + R + + ++ AL VA GM L + Sbjct: 248 VRLLGVILHHG-LYIVMEHVSKGNLVNFLRTRGRALVSTSQLLQFALHVAEGMEYLESK- 305 Query: 2431 PTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAGTPEWMAPEVLRNEQSN 2610 +VHRDL + N+LV ++ KV DFGL++ + L S +W APE L+N + + Sbjct: 306 -KLVHRDLAARNILVSEDLVAKVSDFGLAKAELRKGLDSSRLP--VKWTAPEALKNGRFS 362 Query: 2611 EKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVASIIRDCW 2787 K D++SFGV+LWE+ + R P+ M+ +V AV + R++ P V +++ CW Sbjct: 363 SKSDVWSFGVLLWEVFSYGRAPYPKMSLKEVSEAVE-KGYRMEPPDSCPGPVHTLMGSCW 421 Query: 2788 QKDPNLRPSFIQLTSYL 2838 + +P+ RP F ++ L Sbjct: 422 EAEPSRRPPFRKIVEKL 438
>Q61097:KSR1_MOUSE Kinase suppressor of Ras 1 - Mus musculus (Mouse)| Length = 873 Score = 120 bits (302), Expect = 3e-26 Identities = 87/289 (30%), Positives = 140/289 (48%), Gaps = 20/289 (6%) Frame = +1 Query: 2050 VSECEILWEDLVIDERIGIGSYGEVYHADWNGTEVAVKKFLDQEFYGDALEEFRCEVRIM 2229 + E +I +E + + E IG G +G V+ W+G EVA++ D L+ F+ EV Sbjct: 553 LQEWDIPFEQVELGEPIGQGRWGRVHRGRWHG-EVAIRLLEMDGHNQDHLKLFKKEVMNY 611 Query: 2230 RRLRHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGM 2409 R+ RH N+VLFMGA PPHL+I++ + +L+ + P +D + ++A ++ +GM Sbjct: 612 RQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKGM 671 Query: 2410 NCLHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGL---------SRLKHSTFLSSKSTAG 2562 LH IVH+DLKS N+ DN V + DFGL R ++ LS Sbjct: 672 GYLHAK--GIVHKDLKSKNVFY-DNGKVVITDFGLFGISGVVREERRENQLKLSHDWLC- 727 Query: 2563 TPEWMAPEVLRNE---------QSNEKCDIYSFGVILWELATLRKPWHGMNQMQVVGAVG 2715 ++APE++R ++ D+Y+FG + +EL P+ ++ +G Sbjct: 728 ---YLAPEIVREMIPGRDEDQLPFSKAADVYAFGTVWYELQARDWPFKHQPAEALIWQIG 784 Query: 2716 FQD--RRLDIPKEVDPIVASIIRDCWQKDPNLRPSFIQLTSYLKTLQRL 2856 + RR+ + V I+ CW D RPSF L L+ L +L Sbjct: 785 SGEGVRRVLASVSLGKEVGEILSACWAFDLQERPSFSLLMDMLERLPKL 833
>Q95M30:HCK_MACFA Tyrosine-protein kinase HCK - Macaca fascicularis (Crab eating| macaque) (Cynomolgus monkey) Length = 504 Score = 120 bits (302), Expect = 3e-26 Identities = 80/263 (30%), Positives = 139/263 (52%), Gaps = 4/263 (1%) Frame = +1 Query: 2062 EILWEDLVIDERIGIGSYGEVYHADWNG-TEVAVKKFLDQEFYGDALEEFRCEVRIMRRL 2238 EI E L +++++G G +GEV+ A +N T+VAVK ++E F E +M+ L Sbjct: 234 EIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSM---SVEAFLAEANLMKTL 290 Query: 2239 RHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDE-KRRIKMALDVARGMNC 2415 +H +V VT+ P + I++E++ +GSL + + I + +A GM Sbjct: 291 QHDKLVKLHAVVTKEP-IYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAF 349 Query: 2416 LHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAGTP-EWMAPEVL 2592 + +HRDL++ N+LV + K+ DFGL+R+ +++ A P +W APE + Sbjct: 350 IEQR--NYIHRDLRAANILVSASLVCKIADFGLARIIEDNEYTAREGAKFPIKWTAPEAI 407 Query: 2593 RNEQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVAS 2769 S K D++SFG++L E+ T R P+ GM+ +V+ A+ + R+ P+ + + Sbjct: 408 NFGSSTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALE-RGYRMPRPENCPEELYN 466 Query: 2770 IIRDCWQKDPNLRPSFIQLTSYL 2838 I+ CW+ P RP+F + S L Sbjct: 467 IMMRCWKNRPEERPTFEYIQSVL 489
>P16879:FES_MOUSE Proto-oncogene tyrosine-protein kinase Fes/Fps - Mus musculus (Mouse)| Length = 820 Score = 120 bits (302), Expect = 3e-26 Identities = 81/265 (30%), Positives = 132/265 (49%), Gaps = 5/265 (1%) Frame = +1 Query: 2074 EDLVIDERIGIGSYGEVYHADW--NGTEVAVKKFLDQEFYGDALEEFRCEVRIMRRLRHP 2247 EDLV+ E+IG G++GEV+ + T VAVK + D +F E RI+++ HP Sbjct: 557 EDLVLGEQIGRGNFGEVFSGRLRADNTPVAVKS-CRETLPPDLKAKFLQEARILKQYNHP 615 Query: 2248 NIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGMNCLHTS 2427 NIV +G T+ + IV E + G + ++ K ++M D A GM L + Sbjct: 616 NIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMMGDAAAGMEYLESK 675 Query: 2428 VPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLK-HSTFLSSKSTAGTP-EWMAPEVLRNE 2601 +HRDL + N LV + +K+ DFG+SR + + + P +W APE L Sbjct: 676 --CCIHRDLAARNCLVTEKNVLKISDFGMSREEADGIYAACSGLRQVPVKWTAPEALNYG 733 Query: 2602 QSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVASIIR 2778 + + + D++SFG++LWE +L P+ + Q V + RL P+ V ++ Sbjct: 734 RYSSESDVWSFGILLWETFSLGASPYPNLTNQQTREFVE-KGHRLPCPELCPDAVFRLME 792 Query: 2779 DCWQKDPNLRPSFIQLTSYLKTLQR 2853 CW +P RPSF + L ++++ Sbjct: 793 QCWAYEPGQRPSFSIICQELHSIRK 817
>P00542:FES_FSVGA Tyrosine-protein kinase transforming protein Fes - Feline sarcoma| virus (strain Gardner-Arnstein) (Ga-FeSV) (Gardner-Arnstein feline leukemia oncovirus B) Length = 609 Score = 120 bits (302), Expect = 3e-26 Identities = 81/265 (30%), Positives = 134/265 (50%), Gaps = 5/265 (1%) Frame = +1 Query: 2074 EDLVIDERIGIGSYGEVYHADW--NGTEVAVKKFLDQEFYGDALEEFRCEVRIMRRLRHP 2247 EDLV+ E+IG G++GEV+ + T VAVK + D +F E +I+++ HP Sbjct: 346 EDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKS-CRETLPPDIKAKFLQEAKILKQYSHP 404 Query: 2248 NIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGMNCLHTS 2427 NIV +G T+ + IV E + G + ++ K ++M D A GM L + Sbjct: 405 NIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRMKTLLQMVGDAAAGMEYLESK 464 Query: 2428 VPTIVHRDLKSPNLLVDDNWTVKVCDFGLSR-LKHSTFLSSKSTAGTP-EWMAPEVLRNE 2601 +HRDL + N LV + +K+ DFG+SR + +S P +W APE L Sbjct: 465 --CCIHRDLAARNCLVTEKNVLKISDFGMSREAADGIYAASGGLRQVPVKWTAPEALNYG 522 Query: 2602 QSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVASIIR 2778 + + + D++SFG++LWE +L P+ ++ Q V + RL P+ V ++ Sbjct: 523 RYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVE-KGGRLPCPELCPDAVFRLME 581 Query: 2779 DCWQKDPNLRPSFIQLTSYLKTLQR 2853 CW +P RPSF + L+++++ Sbjct: 582 QCWAYEPGQRPSFSAIYQELQSIRK 606
>P14238:FES_FELCA Proto-oncogene tyrosine-protein kinase Fes/Fps - Felis silvestris| catus (Cat) Length = 820 Score = 120 bits (302), Expect = 3e-26 Identities = 81/265 (30%), Positives = 135/265 (50%), Gaps = 5/265 (1%) Frame = +1 Query: 2074 EDLVIDERIGIGSYGEVYHADW--NGTEVAVKKFLDQEFYGDALEEFRCEVRIMRRLRHP 2247 EDLV+ E+IG G++GEV+ + T VAVK + D +F E +I+++ HP Sbjct: 557 EDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKS-CRETLPPDIKAKFLQEAKILKQYSHP 615 Query: 2248 NIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGMNCLHTS 2427 NIV +G T+ + IV E + G + ++ K ++M D A GM L + Sbjct: 616 NIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRMKTLLQMVGDAAAGMEYLESK 675 Query: 2428 VPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLK-HSTFLSSKSTAGTP-EWMAPEVLRNE 2601 +HRDL + N LV + +K+ DFG+SR + + +S P +W APE L Sbjct: 676 --CCIHRDLAARNCLVTEKNVLKISDFGMSREEADGIYAASGGLRQVPVKWTAPEALNYG 733 Query: 2602 QSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVASIIR 2778 + + + D++SFG++LWE +L P+ ++ Q V + RL P+ V ++ Sbjct: 734 RYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVE-KGGRLPCPELCPDAVFRLME 792 Query: 2779 DCWQKDPNLRPSFIQLTSYLKTLQR 2853 CW +P RPSF + L+++++ Sbjct: 793 QCWAYEPGQRPSFSAIYQELQSIRK 817
>Q91694:EPA4B_XENLA Ephrin type-A receptor 4-B precursor - Xenopus laevis (African clawed| frog) Length = 985 Score = 120 bits (302), Expect = 3e-26 Identities = 81/264 (30%), Positives = 133/264 (50%), Gaps = 8/264 (3%) Frame = +1 Query: 2086 IDERIGIGSYGEVYHADWN---GTEVAVK-KFLDQEFYGDALEEFRCEVRIMRRLRHPNI 2253 I++ IG+G +GEV E+ V K L + +F E IM + HPNI Sbjct: 622 IEKVIGVGEFGEVCSGRLKVPGKREIYVAIKTLKAGYTDKQRRDFLSEASIMGQFDHPNI 681 Query: 2254 VLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGMNCLHTSVP 2433 + G VT+ + I++EY+ GSL + + + + + + M + GM L S Sbjct: 682 IHLEGVVTKCKPVMIITEYMENGSLDAFLRKNDGRFTVIQLVGMLRGIGSGMKYL--SDM 739 Query: 2434 TIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAGTP---EWMAPEVLRNEQ 2604 + VHRDL + N+LV+ N KV DFG+SR+ ++ +T G W APE + + Sbjct: 740 SYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAYRK 799 Query: 2605 SNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVASIIRD 2781 D++S+G+++WE+ + +P+ M+ V+ A+ + RL P + + ++ D Sbjct: 800 FTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIE-EGYRLPPPMDCPIALHQLMLD 858 Query: 2782 CWQKDPNLRPSFIQLTSYLKTLQR 2853 CWQKD + RP F Q+ S L L R Sbjct: 859 CWQKDRSDRPKFGQIVSMLDKLIR 882
>P35991:BTK_MOUSE Tyrosine-protein kinase BTK - Mus musculus (Mouse)| Length = 659 Score = 120 bits (302), Expect = 3e-26 Identities = 82/260 (31%), Positives = 126/260 (48%), Gaps = 3/260 (1%) Frame = +1 Query: 2062 EILWEDLVIDERIGIGSYGEVYHADWNGT-EVAVKKFLDQEFYGDALEEFRCEVRIMRRL 2238 EI +DL + +G G +G V + W G +VA+K + D EF E ++M L Sbjct: 396 EIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIREGSMSED---EFIEEAKVMMNL 452 Query: 2239 RHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGMNCL 2418 H +V G T+ + I++EY+ G L + + ++ ++M DV M L Sbjct: 453 SHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYL 512 Query: 2419 HTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSR-LKHSTFLSSKSTAGTPEWMAPEVLR 2595 + +HRDL + N LV+D VKV DFGLSR + + SS + W PEVL Sbjct: 513 ESK--QFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLM 570 Query: 2596 NEQSNEKCDIYSFGVILWELATLRK-PWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVASI 2772 + + K DI++FGV++WE+ +L K P+ + + Q RL P V +I Sbjct: 571 YSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIA-QGLRLYRPHLASERVYTI 629 Query: 2773 IRDCWQKDPNLRPSFIQLTS 2832 + CW + + RPSF L S Sbjct: 630 MYSCWHEKADERPSFKILLS 649
>P42682:TXK_MOUSE Tyrosine-protein kinase TXK - Mus musculus (Mouse)| Length = 527 Score = 120 bits (301), Expect = 4e-26 Identities = 77/262 (29%), Positives = 126/262 (48%), Gaps = 6/262 (2%) Frame = +1 Query: 2071 WE----DLVIDERIGIGSYGEVYHADWNGTEVAVKKFLDQEFYGDALEEFRCEVRIMRRL 2238 WE +L + IG G +G V+ +W K +++ + E+F E ++M +L Sbjct: 264 WEIDPSELAFVKEIGSGQFGVVHLGEWRAHIPVAIKAINEGSMSE--EDFIEEAKVMMKL 321 Query: 2239 RHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGMNCL 2418 H +V G + L IV+E++ G L + Q+ + + M D+ GM L Sbjct: 322 SHSRLVQLYGVCIQQKPLYIVTEFMENGCLLDYLRERKGQLQKALLLSMCQDICEGMAYL 381 Query: 2419 HTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSR-LKHSTFLSSKSTAGTPEWMAPEVLR 2595 S +HRDL + N LV VK+ DFG++R + ++SS +W PEV Sbjct: 382 ERSC--YIHRDLAARNCLVSSACVVKISDFGMARYVLDDEYISSSGAKFPVKWCPPEVFH 439 Query: 2596 NEQSNEKCDIYSFGVILWELATLRK-PWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVASI 2772 + + K D++SFGV++WE+ T K P+ + +QVV A+ Q RL P + + Sbjct: 440 FNKYSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAIS-QGFRLYRPHLAPMTIYRV 498 Query: 2773 IRDCWQKDPNLRPSFIQLTSYL 2838 + CW + P RP+F +L L Sbjct: 499 MYSCWHESPKGRPTFAELLQVL 520
>Q96S53:TESK2_HUMAN Dual specificity testis-specific protein kinase 2 - Homo sapiens| (Human) Length = 571 Score = 120 bits (301), Expect = 4e-26 Identities = 90/272 (33%), Positives = 143/272 (52%), Gaps = 10/272 (3%) Frame = +1 Query: 2092 ERIGIGSYGEVYHADW--NGTEVAVKKFLDQEFYGDALEEFRCEVRIMRRLRHPNIVLFM 2265 E+IG G + EV+ +G +A+K + L+E V++M RL HPNI+ FM Sbjct: 62 EKIGSGFFSEVFKVRHRASGQVMALKMNTLSSNRANMLKE----VQLMNRLSHPNILRFM 117 Query: 2266 GAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGMNCLHTSVPTIVH 2445 G L ++EY+ G+L +++ N + R+K+A D+A G++ LH I H Sbjct: 118 GVCVHQGQLHALTEYINSGNLEQLLDS-NLHLPWTVRVKLAYDIAVGLSYLHFK--GIFH 174 Query: 2446 RDLKSPNLLV---DDNWTVKVCDFGLSRLKHSTFLSSKSTA--GTPEWMAPEVLRNEQSN 2610 RDL S N L+ ++ ++ V DFGL+ + S+ A G+P WMAPEVLR+E N Sbjct: 175 RDLTSKNCLIKRDENGYSAVVADFGLAEKIPDVSMGSEKLAVVGSPFWMAPEVLRDEPYN 234 Query: 2611 EKCDIYSFGVILWE-LATLRKPWHGMNQMQVVGA--VGFQDRRLDIPKEVDPIVASIIRD 2781 EK D++S+G+IL E +A ++ + + + G FQ D P P + + Sbjct: 235 EKADVFSYGIILCEIIARIQADPDYLPRTENFGLDYDAFQHMVGDCP----PDFLQLTFN 290 Query: 2782 CWQKDPNLRPSFIQLTSYLKTLQRLVIPSHQE 2877 C DP LRPSF+++ KTL+ ++ +E Sbjct: 291 CCNMDPKLRPSFVEIG---KTLEEILSRLQEE 319
>Q3UVC0:KSR2_MOUSE Kinase suppressor of Ras 2 - Mus musculus (Mouse)| Length = 959 Score = 120 bits (301), Expect = 4e-26 Identities = 87/296 (29%), Positives = 144/296 (48%), Gaps = 22/296 (7%) Frame = +1 Query: 2050 VSECEILWEDLVIDERIGIGSYGEVYHADWNGTEVAVKKFLDQEFYGDALEEFRCEVRIM 2229 + E +I +E L I E IG G +G+VYH W+G EVA++ + D L+ F+ EV Sbjct: 666 LQEWDIPFEQLEIGELIGKGRFGQVYHGRWHG-EVAIRLIDIERDNEDQLKAFKREVMAY 724 Query: 2230 RRLRHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGM 2409 R+ RH N+VLFMGA PPHL+I++ +LY ++ +D + ++A ++ +GM Sbjct: 725 RQTRHENVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGM 784 Query: 2410 NCLHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTA-----GTPEW 2574 LH I+H+DLKS N+ DN V + DFGL + + G Sbjct: 785 GYLHAK--GILHKDLKSKNVFY-DNGKVVITDFGLFSISGVLQAGRRDDKLRIQNGWLCH 841 Query: 2575 MAPEVLRNEQS---------NEKCDIYSFGVILWELATLRKPWHGMNQMQVVGAVGFQDR 2727 +APE++R ++ D+++ G I +EL P+ ++ +G + Sbjct: 842 LAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFKTQPAEAIIWQMGTGMK 901 Query: 2728 ----RLDIPKEVDPIVASIIRDCWQKDPNLRPSFIQLTSYLKTL----QRLVIPSH 2871 ++ + KE ++ I+ CW + RP+F +L L+ L +RL P H Sbjct: 902 PNLSQIGMGKE----ISDILLFCWAFEQEERPTFTKLMDMLEKLPKRNRRLSHPGH 953
>Q61772:EPHA7_MOUSE Ephrin type-A receptor 7 precursor - Mus musculus (Mouse)| Length = 998 Score = 120 bits (301), Expect = 4e-26 Identities = 83/264 (31%), Positives = 130/264 (49%), Gaps = 8/264 (3%) Frame = +1 Query: 2086 IDERIGIGSYGEVYHADWN---GTEVAVK-KFLDQEFYGDALEEFRCEVRIMRRLRHPNI 2253 I+ IG G +GEV +VAV K L + +F CE IM + HPN+ Sbjct: 635 IERVIGAGEFGEVCSGRLKLPGQRDVAVAIKTLKVGYTEKQRRDFLCEASIMGQFDHPNV 694 Query: 2254 VLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGMNCLHTSVP 2433 V G VTR + IV E++ G+L + + + Q + + M +A GM L + Sbjct: 695 VHLEGVVTRGKPVMIVIEFMENGALDAFLRKHDGQFTVIQLVGMLRGIAAGMRYL--ADM 752 Query: 2434 TIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAG---TPEWMAPEVLRNEQ 2604 VHRDL + N+LV+ N KV DFGLSR+ + +T G W APE ++ + Sbjct: 753 GYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPEAIQYRK 812 Query: 2605 SNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVASIIRD 2781 D++S+G+++WE+ + +P+ M+ V+ A+ + RL P + + ++ D Sbjct: 813 FTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIE-EGYRLPAPMDCPAGLHQLMLD 871 Query: 2782 CWQKDPNLRPSFIQLTSYLKTLQR 2853 CWQKD RP F Q+ L + R Sbjct: 872 CWQKDRAERPKFEQIVGILDKMIR 895
>P54756:EPHA5_HUMAN Ephrin type-A receptor 5 precursor - Homo sapiens (Human)| Length = 1037 Score = 120 bits (301), Expect = 4e-26 Identities = 86/279 (30%), Positives = 136/279 (48%), Gaps = 9/279 (3%) Frame = +1 Query: 2080 LVIDERIGIGSYGEVYHADWN-----GTEVAVKKFLDQEFYGDALEEFRCEVRIMRRLRH 2244 + I+ IG G +GEV VA+K L + +F E IM + H Sbjct: 675 ITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKT-LKVGYTEKQRRDFLGEASIMGQFDH 733 Query: 2245 PNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGMNCLHT 2424 PNI+ G VT+ + IV+EY+ GSL + + + Q + + M ++ GM L Sbjct: 734 PNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRGISAGMKYL-- 791 Query: 2425 SVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAGTP---EWMAPEVLR 2595 S VHRDL + N+L++ N KV DFGLSR+ ++ +T G W APE + Sbjct: 792 SDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAIA 851 Query: 2596 NEQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVASI 2772 + D++S+G+++WE+ + +P+ M V+ AV + RL P + + + Sbjct: 852 FRKFTSASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVE-EGYRLPSPMDCPAALYQL 910 Query: 2773 IRDCWQKDPNLRPSFIQLTSYLKTLQRLVIPSHQETASN 2889 + DCWQK+ N RP F ++ + L L R PS +T N Sbjct: 911 MLDCWQKERNSRPKFDEIVNMLDKLIR--NPSSLKTLVN 947
>Q9V9J3:SRC42_DROME Tyrosine-protein kinase Src42A - Drosophila melanogaster (Fruit fly)| Length = 517 Score = 120 bits (300), Expect = 5e-26 Identities = 78/246 (31%), Positives = 123/246 (50%), Gaps = 5/246 (2%) Frame = +1 Query: 2095 RIGIGSYGEVYHADWNGTEVAVKKFLDQEFYGDALEEFRCEVRIMRRLRHPNIVLFMGAV 2274 ++G G +G+V+ WN T K L ++F E +IM++LRH ++ Sbjct: 253 KLGSGQFGDVWEGLWNNTTPVAIKTLKSGTMDP--KDFLAEAQIMKKLRHTKLIQLYAVC 310 Query: 2275 TRPPHLSIVSEYLPRGSLYKIIHR---PNCQIDEKRRIKMALDVARGMNCLHTSVPTIVH 2445 T + I++E + GSL + + + + I MA +A GM L + +H Sbjct: 311 TVEEPIYIITELMKHGSLLEYLQAIAGKGRSLKMQTLIDMAAQIAAGMAYLESQ--NYIH 368 Query: 2446 RDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAGTP-EWMAPEVLRNEQSNEKCD 2622 RDL + N+LV D VK+ DFGL+RL ++ A P +W APE + + K D Sbjct: 369 RDLAARNVLVGDGNIVKIADFGLARLIKEDEYEARVGARFPIKWTAPEAANYSKFSIKSD 428 Query: 2623 IYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVASIIRDCWQKDP 2799 ++SFG++L EL T R P+ GM +V+ V R+ P +P + I+ +CW KDP Sbjct: 429 VWSFGILLTELVTYGRIPYPGMTNAEVLTQVE-HGYRMPQPPNCEPRLYEIMLECWHKDP 487 Query: 2800 NLRPSF 2817 RP+F Sbjct: 488 MRRPTF 493
>P21709:EPHA1_HUMAN Ephrin type-A receptor 1 precursor - Homo sapiens (Human)| Length = 976 Score = 120 bits (300), Expect = 5e-26 Identities = 91/295 (30%), Positives = 143/295 (48%), Gaps = 9/295 (3%) Frame = +1 Query: 2041 LDEVSECEILWEDLVIDERIGIGSYGEVYHA-----DWNGTEVAVKKFLDQEFYGDALEE 2205 LD E + W L++D IG G +GEVY + VA+K D G Sbjct: 613 LDFTRELDPAW--LMVDTVIGEGEFGEVYRGTLRLPSQDCKTVAIKTLKDTS-PGGQWWN 669 Query: 2206 FRCEVRIMRRLRHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKM 2385 F E IM + HP+I+ G VT+ + I++E++ G+L + Q+ + + M Sbjct: 670 FLREATIMGQFSHPHILHLEGVVTKRKPIMIITEFMENGALDAFLREREDQLVPGQLVAM 729 Query: 2386 ALDVARGMNCLHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAGT 2565 +A GMN L S VHRDL + N+LV+ N KV DFGL+RL F + T G Sbjct: 730 LQGIASGMNYL--SNHNYVHRDLAARNILVNQNLCCKVSDFGLTRLL-DDFDGTYETQGG 786 Query: 2566 P---EWMAPEVLRNEQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRL 2733 W APE + + D++SFG+++WE+ + KP+ M+ +V+ ++ RL Sbjct: 787 KIPIRWTAPEAIAHRIFTTASDVWSFGIVMWEVLSFGDKPYGEMSNQEVMKSIE-DGYRL 845 Query: 2734 DIPKEVDPIVASIIRDCWQKDPNLRPSFIQLTSYLKTLQRLVIPSHQETASNHVP 2898 P + + ++++CW D RP F +L ++L+ Q L P T +N P Sbjct: 846 PPPVDCPAPLYELMKNCWAYDRARRPHFQKLQAHLE--QLLANPHSLRTIANFDP 898
>O22040:ANP1_ARATH Mitogen-activated protein kinase kinase kinase ANP1 - Arabidopsis| thaliana (Mouse-ear cress) Length = 666 Score = 120 bits (300), Expect = 5e-26 Identities = 85/279 (30%), Positives = 140/279 (50%), Gaps = 16/279 (5%) Frame = +1 Query: 2098 IGIGSYGEVY---HADWNGTEVAVKK------FLDQEFYGDALEEFRCEVRIMRRLRHPN 2250 IG G++G VY + D +G +AVK+ F +E ++E EV++++ L HPN Sbjct: 75 IGRGAFGTVYMGMNLD-SGELLAVKQVLIAANFASKEKTQAHIQELEEEVKLLKNLSHPN 133 Query: 2251 IVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHR----PNCQIDEKRRIKMALDVARGMNCL 2418 IV ++G V L+I+ E++P GS+ ++ + P + R + G+ L Sbjct: 134 IVRYLGTVREDDTLNILLEFVPGGSISSLLEKFGPFPESVVRTYTR-----QLLLGLEYL 188 Query: 2419 HTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSR--LKHSTFLSSKSTAGTPEWMAPEVL 2592 H I+HRD+K N+LVD+ +K+ DFG S+ + +T +KS GTP WMAPEV+ Sbjct: 189 HNHA--IMHRDIKGANILVDNKGCIKLADFGASKQVAELATMTGAKSMKGTPYWMAPEVI 246 Query: 2593 RNEQSNEKCDIYSFGVILWELATLRKPW-HGMNQMQVVGAVGFQDRRLDIPKEVDPIVAS 2769 + DI+S G + E+ T + PW ++ + +G IP + Sbjct: 247 LQTGHSFSADIWSVGCTVIEMVTGKAPWSQQYKEVAAIFFIGTTKSHPPIPDTLSSDAKD 306 Query: 2770 IIRDCWQKDPNLRPSFIQLTSYLKTLQRLVIPSHQETAS 2886 + C Q+ PNLRP+ +L + V+ H+E+AS Sbjct: 307 FLLKCLQEVPNLRPTASELLKH-----PFVMGKHKESAS 340
>Q06806:TIE1_MOUSE Tyrosine-protein kinase receptor Tie-1 precursor - Mus musculus| (Mouse) Length = 1134 Score = 119 bits (299), Expect = 6e-26 Identities = 87/279 (31%), Positives = 133/279 (47%), Gaps = 23/279 (8%) Frame = +1 Query: 2071 WEDLVIDERIGIGSYGEVYHA----DWNGTEVAVKKFLDQEFYGDALEEFRCEVRIMRRL 2238 WED+ ++ IG G++G+V A D A+K + D +F E+ ++ +L Sbjct: 832 WEDITFEDLIGEGNFGQVIRAMIKKDGLKMNAAIKMLKEYASENDH-RDFAGELEVLCKL 890 Query: 2239 -RHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKII---------------HRPNCQIDEK 2370 HPNI+ +GA +L I EY P G+L + H + + Sbjct: 891 GHHPNIINLLGACENRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTLSSR 950 Query: 2371 RRIKMALDVARGMNCLHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSK 2550 + ++ A D A GM L S +HRDL + N+LV +N K+ DFGLSR + + K Sbjct: 951 QLLRFASDAANGMQYL--SEKQFIHRDLAARNVLVGENLASKIADFGLSRGEE---VYVK 1005 Query: 2551 STAG--TPEWMAPEVLRNEQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQ 2721 T G WMA E L K D++SFGV+LWE+ +L P+ GM ++ + Q Sbjct: 1006 KTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLP-Q 1064 Query: 2722 DRRLDIPKEVDPIVASIIRDCWQKDPNLRPSFIQLTSYL 2838 R++ P+ D V ++R CW+ P RP F Q+ L Sbjct: 1065 GYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQL 1103
>P35590:TIE1_HUMAN Tyrosine-protein kinase receptor Tie-1 precursor - Homo sapiens| (Human) Length = 1138 Score = 119 bits (299), Expect = 6e-26 Identities = 87/279 (31%), Positives = 133/279 (47%), Gaps = 23/279 (8%) Frame = +1 Query: 2071 WEDLVIDERIGIGSYGEVYHA----DWNGTEVAVKKFLDQEFYGDALEEFRCEVRIMRRL 2238 WED+ ++ IG G++G+V A D A+K + D +F E+ ++ +L Sbjct: 836 WEDITFEDLIGEGNFGQVIRAMIKKDGLKMNAAIKMLKEYASENDH-RDFAGELEVLCKL 894 Query: 2239 -RHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKII---------------HRPNCQIDEK 2370 HPNI+ +GA +L I EY P G+L + H + + Sbjct: 895 GHHPNIINLLGACKNRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTLSSR 954 Query: 2371 RRIKMALDVARGMNCLHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSK 2550 + ++ A D A GM L S +HRDL + N+LV +N K+ DFGLSR + + K Sbjct: 955 QLLRFASDAANGMQYL--SEKQFIHRDLAARNVLVGENLASKIADFGLSRGEE---VYVK 1009 Query: 2551 STAG--TPEWMAPEVLRNEQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQ 2721 T G WMA E L K D++SFGV+LWE+ +L P+ GM ++ + Q Sbjct: 1010 KTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLP-Q 1068 Query: 2722 DRRLDIPKEVDPIVASIIRDCWQKDPNLRPSFIQLTSYL 2838 R++ P+ D V ++R CW+ P RP F Q+ L Sbjct: 1069 GYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQL 1107
>P06213:INSR_HUMAN Insulin receptor precursor - Homo sapiens (Human)| Length = 1382 Score = 119 bits (299), Expect = 6e-26 Identities = 86/281 (30%), Positives = 140/281 (49%), Gaps = 19/281 (6%) Frame = +1 Query: 2056 ECEILWEDLVIDERIGIGSYGEVYHADWNG-------TEVAVKKFLDQEFYGDALEEFRC 2214 E E+ E + + +G GS+G VY + T VAVK + + +E F Sbjct: 1015 EWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIE-FLN 1073 Query: 2215 EVRIMRRLRHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIH--RPNCQIDEKR----- 2373 E +M+ ++V +G V++ +V E + G L + RP + + R Sbjct: 1074 EASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTL 1133 Query: 2374 --RIKMALDVARGMNCLHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSS 2547 I+MA ++A GM L+ VHRDL + N +V ++TVK+ DFG++R + T Sbjct: 1134 QEMIQMAAEIADGMAYLNAK--KFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYR 1191 Query: 2548 KSTAGT--PEWMAPEVLRNEQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGF 2718 K G WMAPE L++ D++SFGV+LWE+ +L +P+ G++ QV+ V Sbjct: 1192 KGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFV-M 1250 Query: 2719 QDRRLDIPKEVDPIVASIIRDCWQKDPNLRPSFIQLTSYLK 2841 LD P V ++R CWQ +P +RP+F+++ + LK Sbjct: 1251 DGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLLK 1291
>P00543:FES_FSVST Tyrosine-protein kinase transforming protein Fes - Feline sarcoma| virus (strain Snyder-Theilen) Length = 477 Score = 119 bits (299), Expect = 6e-26 Identities = 81/265 (30%), Positives = 134/265 (50%), Gaps = 5/265 (1%) Frame = +1 Query: 2074 EDLVIDERIGIGSYGEVYHADW--NGTEVAVKKFLDQEFYGDALEEFRCEVRIMRRLRHP 2247 EDLV+ E+IG G++GEV+ + T VAVK + D +F E +I+++ HP Sbjct: 214 EDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKS-CRETLPPDIKAKFLQEAKILKQYSHP 272 Query: 2248 NIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGMNCLHTS 2427 NIV +G T+ + IV E + G + ++ K ++M D A GM L + Sbjct: 273 NIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRMKTLLQMVGDAAAGMEYLESK 332 Query: 2428 VPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLK-HSTFLSSKSTAGTP-EWMAPEVLRNE 2601 +HRDL + N LV + +K+ DFG+SR + + +S P +W APE L Sbjct: 333 --CCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRLVPVKWTAPEALNYG 390 Query: 2602 QSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVASIIR 2778 + + + D++SFG++LWE +L P+ ++ Q V + RL P+ V ++ Sbjct: 391 RYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVE-KGGRLPCPELCPDAVFRLME 449 Query: 2779 DCWQKDPNLRPSFIQLTSYLKTLQR 2853 CW +P RPSF L+++++ Sbjct: 450 QCWAYEPGQRPSFSAFYQELQSIRK 474
>Q06187:BTK_HUMAN Tyrosine-protein kinase BTK - Homo sapiens (Human)| Length = 659 Score = 119 bits (299), Expect = 6e-26 Identities = 81/260 (31%), Positives = 126/260 (48%), Gaps = 3/260 (1%) Frame = +1 Query: 2062 EILWEDLVIDERIGIGSYGEVYHADWNGT-EVAVKKFLDQEFYGDALEEFRCEVRIMRRL 2238 EI +DL + +G G +G V + W G +VA+K + D EF E ++M L Sbjct: 396 EIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSED---EFIEEAKVMMNL 452 Query: 2239 RHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGMNCL 2418 H +V G T+ + I++EY+ G L + + ++ ++M DV M L Sbjct: 453 SHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYL 512 Query: 2419 HTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSR-LKHSTFLSSKSTAGTPEWMAPEVLR 2595 + +HRDL + N LV+D VKV DFGLSR + + SS + W PEVL Sbjct: 513 ESK--QFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLM 570 Query: 2596 NEQSNEKCDIYSFGVILWELATLRK-PWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVASI 2772 + + K DI++FGV++WE+ +L K P+ + + Q RL P V +I Sbjct: 571 YSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIA-QGLRLYRPHLASEKVYTI 629 Query: 2773 IRDCWQKDPNLRPSFIQLTS 2832 + CW + + RP+F L S Sbjct: 630 MYSCWHEKADERPTFKILLS 649
>P43298:TMK1_ARATH Putative receptor protein kinase TMK1 precursor - Arabidopsis| thaliana (Mouse-ear cress) Length = 942 Score = 119 bits (298), Expect = 8e-26 Identities = 91/289 (31%), Positives = 144/289 (49%), Gaps = 27/289 (9%) Frame = +1 Query: 2089 DERIGIGSYGEVYHADWN-GTEVAVKKFLDQEFYGDALEEFRCEVRIMRRLRHPNIVLFM 2265 D +G G +G VY + + GT++AVK+ + G EF+ E+ ++ ++RH ++V + Sbjct: 591 DNILGSGGFGVVYKGELHDGTKIAVKRMENGVIAGKGFAEFKSEIAVLTKVRHRHLVTLL 650 Query: 2266 GAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQ----IDEKRRIKMALDVARGMNCLH-TSV 2430 G +V EY+P+G+L + + + + + K+R+ +ALDVARG+ LH + Sbjct: 651 GYCLDGNEKLLVYEYMPQGTLSRHLFEWSEEGLKPLLWKQRLTLALDVARGVEYLHGLAH 710 Query: 2431 PTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKS-TAGTPEWMAPEVLRNEQS 2607 + +HRDLK N+L+ D+ KV DFGL RL S ++ AGT ++APE + Sbjct: 711 QSFIHRDLKPSNILLGDDMRAKVADFGLVRLAPEGKGSIETRIAGTFGYLAPEYAVTGRV 770 Query: 2608 NEKCDIYSFGVILWELATLRK--------------PWHGMNQMQVVGAVGFQ---DRRLD 2736 K D+YSFGVIL EL T RK W +M + F+ D +D Sbjct: 771 TTKVDVYSFGVILMELITGRKSLDESQPEESIHLVSW--FKRMYINKEASFKKAIDTTID 828 Query: 2737 IPKEV---DPIVASIIRDCWQKDPNLRPSFIQLTSYLKTLQRLVIPSHQ 2874 + +E VA + C ++P RP + L +L L PS Q Sbjct: 829 LDEETLASVHTVAELAGHCCAREPYQRPDMGHAVNILSSLVELWKPSDQ 877
>Q06805:TIE1_BOVIN Tyrosine-protein kinase receptor Tie-1 precursor - Bos taurus| (Bovine) Length = 1136 Score = 119 bits (298), Expect = 8e-26 Identities = 87/279 (31%), Positives = 133/279 (47%), Gaps = 23/279 (8%) Frame = +1 Query: 2071 WEDLVIDERIGIGSYGEVYHA----DWNGTEVAVKKFLDQEFYGDALEEFRCEVRIMRRL 2238 WED+ ++ IG G++G+V A D A+K + D +F E+ ++ +L Sbjct: 834 WEDITFEDLIGEGNFGQVIRAMIKKDGLKMNAAIKMLKEYASENDH-RDFAGELEVLCKL 892 Query: 2239 -RHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKII---------------HRPNCQIDEK 2370 HPNI+ +GA +L I EY P G+L + H + + Sbjct: 893 GHHPNIINLLGACENRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTLSSR 952 Query: 2371 RRIKMALDVARGMNCLHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSK 2550 + ++ A D A GM L S +HRDL + N+LV +N K+ DFGLSR + + K Sbjct: 953 QLLRFASDAANGMQYL--SEKQFIHRDLAARNVLVGENLASKIADFGLSRGEE---VYVK 1007 Query: 2551 STAG--TPEWMAPEVLRNEQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQ 2721 T G WMA E L K D++SFGV+LWE+ +L P+ GM ++ + Q Sbjct: 1008 KTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLP-Q 1066 Query: 2722 DRRLDIPKEVDPIVASIIRDCWQKDPNLRPSFIQLTSYL 2838 R++ P+ D V ++R CW+ P RP F Q+ L Sbjct: 1067 AYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQL 1105
>O42565:LIMK1_XENLA LIM domain kinase 1 - Xenopus laevis (African clawed frog)| Length = 615 Score = 119 bits (298), Expect = 8e-26 Identities = 90/283 (31%), Positives = 137/283 (48%), Gaps = 16/283 (5%) Frame = +1 Query: 2077 DLVIDERIGIGSYGEVYHADWNGT-EVAVKKFLDQEFYGDALEEFRCEVRIMRRLRHPNI 2253 DL+ E +G G +G+ T EV V K L + F + F EV++MR L HP++ Sbjct: 313 DLIPGEVLGRGCFGQAIKVTHRVTGEVMVMKELIR-FDEETQRTFLKEVKVMRCLEHPHV 371 Query: 2254 VLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGMNCLHTSVP 2433 + F+G + + L+ ++EY+P G+L ++I + +R+ A D+A GM LH+ Sbjct: 372 LKFIGVLYKDKRLNFITEYIPGGTLRRVIKSMDTHCPWNQRVSFARDIAAGMTYLHSM-- 429 Query: 2434 TIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSK-------STAGTPEWMAPEVL 2592 I+HRDL S N LV ++ + V +FGLSRL + + G P WMAPE++ Sbjct: 430 NIIHRDLNSHNCLVREDGGLVVANFGLSRLIPEETRDLRKDRRKRYTVVGNPYWMAPEMI 489 Query: 2593 RNEQSNEKCDIYSFGVILWELATL--RKPWHGMNQMQV-VGAVGFQDRRLDIPKEVDPIV 2763 +E D++SFG+++ E+ L P + M + F DR P P Sbjct: 490 NGRSYDESVDVFSFGIVICEIIGLVNADPDYLPRTMDFGLNVRAFLDR--FCPPNCPPGF 547 Query: 2764 ASIIRDCWQKDPNLRPSFIQLTSYLKTLQR-----LVIPSHQE 2877 C DP RP F QL +L +L R L + SH E Sbjct: 548 FPSAVLCCDLDPEKRPRFSQLQLWLDSLLRHLNLQLPLSSHIE 590
>P14617:INSRR_CAVPO Insulin receptor-related protein precursor - Cavia porcellus (Guinea| pig) Length = 1300 Score = 119 bits (298), Expect = 8e-26 Identities = 96/322 (29%), Positives = 163/322 (50%), Gaps = 22/322 (6%) Frame = +1 Query: 1999 VSPSQVGSSKVDLVLDEVSECEILWEDLVIDERIGIGSYGEVYHADWNGTE-------VA 2157 V+P + +S D+ + + E E+ E + I +G GS+G VY G E VA Sbjct: 956 VNPEYLSAS--DMYIPD--EWEVPREQISIIRELGQGSFGMVYEGVAKGLEAGEESTPVA 1011 Query: 2158 VKKFLDQEFYGDALEEFRCEVRIMRRLRHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKI 2337 +K + + +E F E +M+ + ++V +G V++ ++ E + RG L Sbjct: 1012 LKTVNELASPRERIE-FLKEASVMKAFQCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSH 1070 Query: 2338 IH--RPNCQIDEK-------RRIKMALDVARGMNCLHTSVPTIVHRDLKSPNLLVDDNWT 2490 + RP + + I+MA ++A GM L + VHRDL + N +V ++T Sbjct: 1071 LRSLRPEAENNPGIPRPALGDMIQMAGEIADGMAYLAAN--KFVHRDLAARNCMVSQDFT 1128 Query: 2491 VKVCDFGLSRLKHSTFLSSKSTAGT--PEWMAPEVLRNEQSNEKCDIYSFGVILWELATL 2664 VK+ DFG++R + T K G WMAPE L++ D++SFGV+LWE+ TL Sbjct: 1129 VKIGDFGMTRDVYETDYYRKGGKGLLPVRWMAPESLKDGIFTTHSDVWSFGVVLWEIVTL 1188 Query: 2665 -RKPWHGMNQMQVVGAV---GFQDRRLDIPKEVDPIVASIIRDCWQKDPNLRPSFIQLTS 2832 +P+ G++ QV+ V G + D P ++ +++S CWQ++P LRP+F Q+ Sbjct: 1189 AEQPYQGLSNEQVLKFVMDGGVLEELEDCPHQLQELMSS----CWQQNPRLRPTFTQI-- 1242 Query: 2833 YLKTLQRLVIPSHQETASNHVP 2898 L ++Q+ + PS + + H P Sbjct: 1243 -LNSIQKELRPSFRLLSFYHSP 1263
>P22607:FGFR3_HUMAN Fibroblast growth factor receptor 3 precursor - Homo sapiens (Human)| Length = 806 Score = 119 bits (298), Expect = 8e-26 Identities = 98/324 (30%), Positives = 156/324 (48%), Gaps = 36/324 (11%) Frame = +1 Query: 2041 LDEVSECEI----LWE----DLVIDERIGIGSYGEVYHADWNGTE---------VAVKKF 2169 L VSE E+ WE L + + +G G +G+V A+ G + VAVK Sbjct: 451 LANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKML 510 Query: 2170 LDQEFYGDALEEFRCEVRIMRRL-RHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHR 2346 D D L + E+ +M+ + +H NI+ +GA T+ L ++ EY +G+L + + Sbjct: 511 KDDATDKD-LSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRA 569 Query: 2347 ---------------PNCQIDEKRRIKMALDVARGMNCLHTSVPTIVHRDLKSPNLLVDD 2481 P Q+ K + A VARGM L + +HRDL + N+LV + Sbjct: 570 RRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQ--KCIHRDLAARNVLVTE 627 Query: 2482 NWTVKVCDFGLSRLKHSTFLSSKSTAGT--PEWMAPEVLRNEQSNEKCDIYSFGVILWEL 2655 + +K+ DFGL+R H+ K+T G +WMAPE L + + D++SFGV+LWE+ Sbjct: 628 DNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEI 687 Query: 2656 ATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVASIIRDCWQKDPNLRPSFIQLTS 2832 TL P+ G+ ++ + + R+D P + I+R+CW P+ RP+F QL Sbjct: 688 FTLGGSPYPGIPVEELFKLLK-EGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVE 746 Query: 2833 YLKTLQRLVIPSHQETASNHVPYE 2904 L + L + S E P+E Sbjct: 747 DLDRV--LTVTSTDEYLDLSAPFE 768
>O65472:CRK12_ARATH Putative cysteine-rich receptor-like protein kinase 12 precursor -| Arabidopsis thaliana (Mouse-ear cress) Length = 690 Score = 119 bits (298), Expect = 8e-26 Identities = 79/244 (32%), Positives = 130/244 (53%), Gaps = 6/244 (2%) Frame = +1 Query: 1957 LDRFMDRPRQNIECVSPSQVGSSKVDLVLDEVSECEILWEDLVIDERIGIGSYGEVYHAD 2136 L R R R++ + + Q G + + + E+ E+ ++G G +GEVY Sbjct: 326 LSRLFARRRKSYQEIDLDQSGITTLHFQQLDFKTIEVATENFAKTNKLGQGGFGEVYKGT 385 Query: 2137 W-NGTEVAVKKFLDQEFYGDALEEFRCEVRIMRRLRHPNIVLFMGAVTRPPHLSIVSEYL 2313 NGTEVAVK+ G +EF+ EV ++ +L+H N+V +G P +V E++ Sbjct: 386 LVNGTEVAVKRLSKTSEQG--AQEFKNEVVLVAKLQHRNLVKLLGYCLEPEEKILVYEFV 443 Query: 2314 PRGSLYKIIHRPNCQ--IDEKRRIKMALDVARGMNCLHT-SVPTIVHRDLKSPNLLVDDN 2484 P SL + P Q +D +R + + RG+ LH S TI+HRDLK+ N+L+D + Sbjct: 444 PNKSLDYFLFDPTKQGQLDWTKRYNIIGGITRGILYLHQDSRLTIIHRDLKASNILLDAD 503 Query: 2485 WTVKVCDFGLSRLK--HSTFLSSKSTAGTPEWMAPEVLRNEQSNEKCDIYSFGVILWELA 2658 K+ DFG++R+ + ++K AGT +M PE + + Q + K D+YSFGV++ E+ Sbjct: 504 MIPKIADFGMARISGIDQSVANTKRIAGTFGYMPPEYVIHGQFSMKSDVYSFGVLILEII 563 Query: 2659 TLRK 2670 +K Sbjct: 564 CGKK 567
>P08630:BTKL_DROME Tyrosine-protein kinase Btk29A - Drosophila melanogaster (Fruit fly)| Length = 786 Score = 119 bits (298), Expect = 8e-26 Identities = 82/265 (30%), Positives = 133/265 (50%), Gaps = 9/265 (3%) Frame = +1 Query: 2071 WE----DLVIDERIGIGSYGEVYHADWNGT-EVAVKKFLDQEFYGDALEEFRCEVRIMRR 2235 WE +L++ E +G G +G V W G+ + AVK + D +F E ++M + Sbjct: 519 WEIHPMELMLMEELGSGQFGVVRRGKWRGSIDTAVKMMKEGTMSED---DFIEEAKVMTK 575 Query: 2236 LRHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQI--DEKRRIKMALDVARGM 2409 L+HPN+V G ++ + IV+EY+ GSL + R + + + M + V++GM Sbjct: 576 LQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGLLLDMCIQVSKGM 635 Query: 2410 NCLHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSR-LKHSTFLSSKSTAGTPEWMAPE 2586 L +HRDL + N LV VKV DFGL+R + + SS T +W PE Sbjct: 636 TYLERH--NYIHRDLAARNCLVGSENVVKVADFGLARYVLDDQYTSSGGTKFPIKWAPPE 693 Query: 2587 VLRNEQSNEKCDIYSFGVILWELATLRK-PWHGMNQMQVVGAVGFQDRRLDIPKEVDPIV 2763 VL + + K D++++GV++WE+ T K P+ + +VV V + L+ PK + Sbjct: 694 VLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERVQ-RGIILEKPKSCAKEI 752 Query: 2764 ASIIRDCWQKDPNLRPSFIQLTSYL 2838 +++ CW P RP+F L L Sbjct: 753 YDVMKLCWSHGPEERPAFRVLMDQL 777
>Q924U5:TESK2_RAT Dual specificity testis-specific protein kinase 2 - Rattus norvegicus| (Rat) Length = 570 Score = 119 bits (297), Expect = 1e-25 Identities = 99/322 (30%), Positives = 158/322 (49%), Gaps = 10/322 (3%) Frame = +1 Query: 1942 PRKSPLDRFMDRPRQNIECVSPSQVGSSKVDLVLDEVSECEILWEDLVIDERIGIGSYGE 2121 PR L+ F + V +V SS ++ S L D E+IG G + E Sbjct: 14 PRVERLEEFEGGGGGDGNTVQVGRVSSSSYRAIISAFSRLTSL--DDFTREKIGSGFFSE 71 Query: 2122 VYHADW--NGTEVAVKKFLDQEFYGDALEEFRCEVRIMRRLRHPNIVLFMGAVTRPPHLS 2295 V+ +G +A+K + L+E +++M RL HPNI+ FMG L Sbjct: 72 VFKVRHRASGQVMALKMNTLSSNRANLLKE----MQLMNRLSHPNILRFMGVCVHQGQLH 127 Query: 2296 IVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGMNCLHTSVPTIVHRDLKSPNLLV 2475 ++EY+ G+L +++ N + R+K+A D+A G++ LH I HRDL S N L+ Sbjct: 128 ALTEYINSGNLEQLLDS-NLYLPWTVRVKLAYDIAVGLSYLHFK--GIFHRDLTSKNCLI 184 Query: 2476 ---DDNWTVKVCDFGLSRLKHSTFLSSKSTA--GTPEWMAPEVLRNEQSNEKCDIYSFGV 2640 ++ ++ V DFGL+ + S+ A G+P WMAPEVLR+E NEK D++S+G+ Sbjct: 185 KRDENGYSAVVADFGLAEKIPDASIGSEKLAVVGSPFWMAPEVLRDEPYNEKADVFSYGI 244 Query: 2641 ILWE-LATLRKPWHGMNQMQVVGA--VGFQDRRLDIPKEVDPIVASIIRDCWQKDPNLRP 2811 IL E +A ++ + + + G FQ D P + + +C DP LRP Sbjct: 245 ILCEIIARIQADPDYLPRTENFGLDYDAFQHMVGDCPSD----FLQLTFNCCNMDPKLRP 300 Query: 2812 SFIQLTSYLKTLQRLVIPSHQE 2877 SF ++ KTL+ ++ +E Sbjct: 301 SFEEIG---KTLEEIMSRLQEE 319
>P17713:STK_HYDAT Tyrosine-protein kinase STK - Hydra attenuata (Hydra) (Hydra| vulgaris) Length = 509 Score = 119 bits (297), Expect = 1e-25 Identities = 85/263 (32%), Positives = 128/263 (48%), Gaps = 3/263 (1%) Frame = +1 Query: 2062 EILWEDLVIDERIGIGSYGEVYHADWNGTEVAVKKFLDQEFYGDALEEFRCEVRIMRRLR 2241 EI E L ++ ++G G +GEV+ WN T K L A F E +M++LR Sbjct: 234 EIPRESLRLNRKLGAGQFGEVWAGVWNNTTQVAVKTLKPGTMSPA--SFLDEAGVMKKLR 291 Query: 2242 HPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHR-PNCQIDEKRRIKMALDVARGMNCL 2418 H ++V + + IV+EY+ GSL + + + I MA VA GM L Sbjct: 292 HKHLVQLYAICSDREPIYIVTEYMSGGSLLDYLSKGEGVNLQLPTLIDMAAQVASGMAFL 351 Query: 2419 HTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAGTP-EWMAPEVLR 2595 +HRDL + N+LV +N+ KV DFGL+RL ++ A P +W APE Sbjct: 352 EAQ--GYIHRDLAARNILVGENYICKVADFGLARLIEDDEYTAHEGAKFPIKWTAPEAAL 409 Query: 2596 NEQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVASI 2772 + K D++SFG+++ E+ T R P+ GM Q + V R +P +P+ +I Sbjct: 410 YNRFTIKSDVWSFGILMAEIVTKGRIPYPGMTNAQTIAEVEKGYRMPIMPGCPEPLY-NI 468 Query: 2773 IRDCWQKDPNLRPSFIQLTSYLK 2841 + W KDP RP+F L L+ Sbjct: 469 MLQTWNKDPENRPTFDYLQGVLE 491
>Q3UFB7:NTRK1_MOUSE High affinity nerve growth factor receptor precursor - Mus musculus| (Mouse) Length = 799 Score = 119 bits (297), Expect = 1e-25 Identities = 84/282 (29%), Positives = 146/282 (51%), Gaps = 24/282 (8%) Frame = +1 Query: 2074 EDLVIDERIGIGSYGEVYHA-------DWNGTEVAVKKFLDQEFYGDALEEFRCEVRIMR 2232 +D+++ +G G++G+V+ A D + VAVK +E +A ++F+ E ++ Sbjct: 511 QDIILKWELGEGAFGKVFLAECYNLLNDQDKMLVAVKAL--KEASENARQDFQREAELLT 568 Query: 2233 RLRHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKII--HRPNCQI------------DEK 2370 L+H +IV F G T L +V EY+ G L + + H P+ ++ Sbjct: 569 MLQHQHIVRFFGVCTEGGPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLG 628 Query: 2371 RRIKMALDVARGMNCLHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHST--FLS 2544 + + +A VA GM ++ + VHRDL + N LV VK+ DFG+SR +ST + Sbjct: 629 QLLAVASQVAAGM--VYLASLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRV 686 Query: 2545 SKSTAGTPEWMAPEVLRNEQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQ 2721 T WM PE + + + + D++SFGV+LWE+ T ++PW+ ++ + + + Q Sbjct: 687 GGRTMLPIRWMPPESILYRKFSTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIECI-TQ 745 Query: 2722 DRRLDIPKEVDPIVASIIRDCWQKDPNLRPSFIQLTSYLKTL 2847 R L+ P+ P V +I+R CWQ++P R S + + L+ L Sbjct: 746 GRELERPRACPPDVYAIMRGCWQREPQQRLSMKDVHARLQAL 787
>Q8IVH8:M4K3_HUMAN Mitogen-activated protein kinase kinase kinase kinase 3 - Homo| sapiens (Human) Length = 894 Score = 119 bits (297), Expect = 1e-25 Identities = 86/268 (32%), Positives = 135/268 (50%), Gaps = 7/268 (2%) Frame = +1 Query: 2074 EDLVIDERIGIGSYGEVYHA-DWNGTEVAVKKFLDQEFYGDALEEFRCEVRIMRRLRHPN 2250 ED + +RIG G+YG+VY A + N E+A K + E G+ + E+ +M+ +HPN Sbjct: 14 EDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLE-PGEDFAVVQQEIIMMKDCKHPN 72 Query: 2251 IVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGMNCLHTSV 2430 IV + G+ R L I E+ GSL I H + E + ++ + +G+ LH+ Sbjct: 73 IVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTG-PLSELQIAYVSRETLQGLYYLHSKG 131 Query: 2431 PTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAGTPEWMAPEVLRNEQS- 2607 +HRD+K N+L+ DN VK+ DFG+S +T KS GTP WMAPEV E+ Sbjct: 132 K--MHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKG 189 Query: 2608 --NEKCDIYSFGVILWELATLRKPW---HGMNQMQVVGAVGFQDRRLDIPKEVDPIVASI 2772 N+ CD+++ G+ ELA L+ P H M + ++ FQ +L + Sbjct: 190 GYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSNSFHHF 249 Query: 2773 IRDCWQKDPNLRPSFIQLTSYLKTLQRL 2856 ++ K+P RP+ +L + Q L Sbjct: 250 VKMALTKNPKKRPTAEKLLQHPFVTQHL 277
>Q8IVT5:KSR1_HUMAN Kinase suppressor of Ras 1 - Homo sapiens (Human)| Length = 921 Score = 119 bits (297), Expect = 1e-25 Identities = 86/289 (29%), Positives = 139/289 (48%), Gaps = 20/289 (6%) Frame = +1 Query: 2050 VSECEILWEDLVIDERIGIGSYGEVYHADWNGTEVAVKKFLDQEFYGDALEEFRCEVRIM 2229 + E +I +E + + E IG G +G V+ W+G EVA++ D L+ F+ EV Sbjct: 601 LQEWDIPFEQVELGEPIGQGRWGRVHRGRWHG-EVAIRLLEMDGHNQDHLKLFKKEVMNY 659 Query: 2230 RRLRHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGM 2409 R+ RH N+VLFMGA PPHL+I++ + +L+ + P +D + ++A ++ +GM Sbjct: 660 RQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKGM 719 Query: 2410 NCLHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGL---------SRLKHSTFLSSKSTAG 2562 LH IVH+DLKS N+ DN V + DFGL R ++ LS Sbjct: 720 GYLHAK--GIVHKDLKSKNVFY-DNGKVVITDFGLFGISGVVREGRRENQLKLSHDWLC- 775 Query: 2563 TPEWMAPEVLRNEQS---------NEKCDIYSFGVILWELATLRKPWHGMNQMQVVGAVG 2715 ++APE++R ++ D+Y+FG + +EL P + +G Sbjct: 776 ---YLAPEIVREMTPGKDEDQLPFSKAADVYAFGTVWYELQARDWPLKNQAAEASIWQIG 832 Query: 2716 FQD--RRLDIPKEVDPIVASIIRDCWQKDPNLRPSFIQLTSYLKTLQRL 2856 + +R+ + V+ I+ CW D RPSF L L+ L +L Sbjct: 833 SGEGMKRVLTSVSLGKEVSEILSACWAFDLQERPSFSLLMDMLEKLPKL 881
>Q61851:FGFR3_MOUSE Fibroblast growth factor receptor 3 precursor - Mus musculus (Mouse)| Length = 801 Score = 119 bits (297), Expect = 1e-25 Identities = 99/326 (30%), Positives = 157/326 (48%), Gaps = 37/326 (11%) Frame = +1 Query: 2038 VLDEVSECEI----LWE----DLVIDERIGIGSYGEVYHADWNGTE---------VAVKK 2166 VL VSE E+ WE L + + +G G +G+V A+ G + VAVK Sbjct: 444 VLANVSELELPADPKWELSRTRLTLGKPLGEGCFGQVVMAEAIGIDKDRTAKPVTVAVKM 503 Query: 2167 FLDQEFYGDALEEFRCEVRIMRRL-RHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIH 2343 D D L + E+ +M+ + +H NI+ +GA T+ L ++ EY +G+L + + Sbjct: 504 LKDDATDKD-LSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLR 562 Query: 2344 R---------------PNCQIDEKRRIKMALDVARGMNCLHTSVPTIVHRDLKSPNLLVD 2478 P Q+ K + A VARGM L + +HRDL + N+LV Sbjct: 563 ARRPPGMDYSFDACRLPEEQLTCKDLVSCAYQVARGMEYLASQ--KCIHRDLAARNVLVT 620 Query: 2479 DNWTVKVCDFGLSRLKHSTFLSSKSTAGT--PEWMAPEVLRNEQSNEKCDIYSFGVILWE 2652 ++ +K+ DFGL+R H+ K+T G +WMAPE L + + D++SFGV+LWE Sbjct: 621 EDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWE 680 Query: 2653 LATL--RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVASIIRDCWQKDPNLRPSFIQL 2826 + T P+ G+ ++ + + R+D P + I+R+CW P+ RP+F QL Sbjct: 681 IFTPGGPSPYPGIPVEELFKLLK-EGHRMDKPASCTHDLYMIMRECWHAVPSQRPTFKQL 739 Query: 2827 TSYLKTLQRLVIPSHQETASNHVPYE 2904 L + L + S E VP+E Sbjct: 740 VEDLDRI--LTVTSTDEYLDLSVPFE 763
>P34152:FAK1_MOUSE Focal adhesion kinase 1 - Mus musculus (Mouse)| Length = 1090 Score = 119 bits (297), Expect = 1e-25 Identities = 84/277 (30%), Positives = 136/277 (49%), Gaps = 8/277 (2%) Frame = +1 Query: 2041 LDEVSECEILWEDLVIDERIGIGSYGEVYHADWNGTE-----VAVKKFLDQEFYGDAL-E 2202 +DE + EI E + + IG G +G+V+ + E VA+K + D++ E Sbjct: 447 IDEARDYEIQRERIELGRCIGEGQFGDVHQGVYLSPENPALAVAIKTC--KNCTSDSVRE 504 Query: 2203 EFRCEVRIMRRLRHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIK 2382 +F E MR+ HP+IV +G +T P + I+ E G L + +D I Sbjct: 505 KFLQEALTMRQFDHPHIVKLIGVITENP-VWIIMELCTLGELRSFLQVRKYSLDLASLIL 563 Query: 2383 MALDVARGMNCLHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSR-LKHSTFLSSKSTA 2559 A ++ + L + VHRD+ + N+LV N VK+ DFGLSR ++ ST+ + Sbjct: 564 YAYQLSTALAYLESK--RFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGK 621 Query: 2560 GTPEWMAPEVLRNEQSNEKCDIYSFGVILWELATLR-KPWHGMNQMQVVGAVGFQDRRLD 2736 +WMAPE + + D++ FGV +WE+ KP+ G+ V+G + RL Sbjct: 622 LPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIE-NGERLP 680 Query: 2737 IPKEVDPIVASIIRDCWQKDPNLRPSFIQLTSYLKTL 2847 +P P + S++ CW DP+ RP F +L + L T+ Sbjct: 681 MPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTI 717
>O09127:EPHA8_MOUSE Ephrin type-A receptor 8 precursor - Mus musculus (Mouse)| Length = 1004 Score = 119 bits (297), Expect = 1e-25 Identities = 97/309 (31%), Positives = 136/309 (44%), Gaps = 4/309 (1%) Frame = +1 Query: 1933 HPDPRKSPLDRFMDRPRQNIECVSPSQVGSSKVDLVLDEVSECEILWEDLVIDERIGIGS 2112 HP P K P +F P E P + G S E+ I E ++ G Sbjct: 598 HP-PGKFPETQFSAEPHTYEE---PGRAGRS----FTREIEASRIHIEKIIGSGESGEVC 649 Query: 2113 YGEVYHADWNGTEVAVKKFLDQEFYGDALEEFRCEVRIMRRLRHPNIVLFMGAVTRPPHL 2292 YG + VA+K L + ++F E IM + HPNI+ G VTR Sbjct: 650 YGRLQVPGQRDVPVAIKA-LKAGYTERQRQDFLSEAAIMGQFDHPNIIRLEGVVTRGRLA 708 Query: 2293 SIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGMNCLHTSVPTIVHRDLKSPNLL 2472 IV+EY+ GSL + + Q + + M V GM L S +HRDL + N+L Sbjct: 709 MIVTEYMENGSLDAFLRTHDGQFTIVQLVGMLRGVGAGMRYL--SDLGYIHRDLAARNVL 766 Query: 2473 VDDNWTVKVCDFGLSRLKHSTFLSSKSTAGTP---EWMAPEVLRNEQSNEKCDIYSFGVI 2643 VD KV DFGLSR ++ +TAG W APE + + D++SFGV+ Sbjct: 767 VDGRLVCKVSDFGLSRALEDDPEAAYTTAGGKIPIRWTAPEAIAFRTFSSASDVWSFGVV 826 Query: 2644 LWE-LATLRKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVASIIRDCWQKDPNLRPSFI 2820 +WE LA +P+ M V+ +V + RL P + ++ DCW KD RP F Sbjct: 827 MWEVLAYGERPYWNMTNQDVISSVE-EGYRLPAPMGCPRALHQLMLDCWHKDRAQRPRFA 885 Query: 2821 QLTSYLKTL 2847 + S L L Sbjct: 886 HVVSVLDAL 894
>P54759:EPHA7_RAT Ephrin type-A receptor 7 precursor - Rattus norvegicus (Rat)| Length = 998 Score = 119 bits (297), Expect = 1e-25 Identities = 82/264 (31%), Positives = 130/264 (49%), Gaps = 8/264 (3%) Frame = +1 Query: 2086 IDERIGIGSYGEVYHADWN---GTEVAVK-KFLDQEFYGDALEEFRCEVRIMRRLRHPNI 2253 I+ IG G +GEV +VAV K L + +F CE IM + HPN+ Sbjct: 635 IERVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTEKQRRDFLCEASIMGQFDHPNV 694 Query: 2254 VLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGMNCLHTSVP 2433 V G VTR + IV E++ G+L + + + Q + + M +A GM L + Sbjct: 695 VHLEGVVTRGKPVMIVIEFMENGALDAFLRKHDGQFTVIQLVGMLRGIAAGMRYL--ADM 752 Query: 2434 TIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAG---TPEWMAPEVLRNEQ 2604 VHRDL + N+LV+ N KV DFGLSR+ + +T G W APE ++ + Sbjct: 753 GYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPEAIQYRK 812 Query: 2605 SNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVASIIRD 2781 D++S+G+++WE+ + +P+ M+ V+ A+ + RL P + + ++ D Sbjct: 813 FTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIE-EGYRLPAPMDCPAGLHQLMLD 871 Query: 2782 CWQKDPNLRPSFIQLTSYLKTLQR 2853 CWQK+ RP F Q+ L + R Sbjct: 872 CWQKERAERPKFEQIVGILDKMIR 895
>Q15375:EPHA7_HUMAN Ephrin type-A receptor 7 precursor - Homo sapiens (Human)| Length = 998 Score = 119 bits (297), Expect = 1e-25 Identities = 82/264 (31%), Positives = 130/264 (49%), Gaps = 8/264 (3%) Frame = +1 Query: 2086 IDERIGIGSYGEVYHADWN---GTEVAVK-KFLDQEFYGDALEEFRCEVRIMRRLRHPNI 2253 I+ IG G +GEV +VAV K L + +F CE IM + HPN+ Sbjct: 635 IERVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTEKQRRDFLCEASIMGQFDHPNV 694 Query: 2254 VLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGMNCLHTSVP 2433 V G VTR + IV E++ G+L + + + Q + + M +A GM L + Sbjct: 695 VHLEGVVTRGKPVMIVIEFMENGALDAFLRKHDGQFTVIQLVGMLRGIAAGMRYL--ADM 752 Query: 2434 TIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAG---TPEWMAPEVLRNEQ 2604 VHRDL + N+LV+ N KV DFGLSR+ + +T G W APE ++ + Sbjct: 753 GYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPEAIQYRK 812 Query: 2605 SNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVASIIRD 2781 D++S+G+++WE+ + +P+ M+ V+ A+ + RL P + + ++ D Sbjct: 813 FTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIE-EGYRLPAPMDCPAGLHQLMLD 871 Query: 2782 CWQKDPNLRPSFIQLTSYLKTLQR 2853 CWQK+ RP F Q+ L + R Sbjct: 872 CWQKERAERPKFEQIVGILDKMIR 895
>Q03137:EPHA4_MOUSE Ephrin type-A receptor 4 precursor - Mus musculus (Mouse)| Length = 986 Score = 119 bits (297), Expect = 1e-25 Identities = 79/264 (29%), Positives = 133/264 (50%), Gaps = 8/264 (3%) Frame = +1 Query: 2086 IDERIGIGSYGEVYHADWN---GTEVAVK-KFLDQEFYGDALEEFRCEVRIMRRLRHPNI 2253 I++ IG+G +GEV E+ V K L + +F E IM + HPNI Sbjct: 623 IEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQRRDFLSEASIMGQFDHPNI 682 Query: 2254 VLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGMNCLHTSVP 2433 + G VT+ + I++EY+ GSL + + + + + + M + GM L S Sbjct: 683 IHLEGVVTKCKPVMIITEYMENGSLDAFLRKNDGRFTVIQLVGMLRGIGSGMKYL--SDM 740 Query: 2434 TIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAGTP---EWMAPEVLRNEQ 2604 + VHRDL + N+LV+ N KV DFG+SR+ ++ +T G W APE + + Sbjct: 741 SYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAYRK 800 Query: 2605 SNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVASIIRD 2781 D++S+G+++WE+ + +P+ M+ V+ A+ + RL P + + ++ D Sbjct: 801 FTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIE-EGYRLPPPMDCPIALHQLMLD 859 Query: 2782 CWQKDPNLRPSFIQLTSYLKTLQR 2853 CWQK+ + RP F Q+ + L L R Sbjct: 860 CWQKERSDRPKFGQIVNMLDKLIR 883
>P54764:EPHA4_HUMAN Ephrin type-A receptor 4 precursor - Homo sapiens (Human)| Length = 986 Score = 119 bits (297), Expect = 1e-25 Identities = 79/264 (29%), Positives = 133/264 (50%), Gaps = 8/264 (3%) Frame = +1 Query: 2086 IDERIGIGSYGEVYHADWN---GTEVAVK-KFLDQEFYGDALEEFRCEVRIMRRLRHPNI 2253 I++ IG+G +GEV E+ V K L + +F E IM + HPNI Sbjct: 623 IEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQRRDFLSEASIMGQFDHPNI 682 Query: 2254 VLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGMNCLHTSVP 2433 + G VT+ + I++EY+ GSL + + + + + + M + GM L S Sbjct: 683 IHLEGVVTKCKPVMIITEYMENGSLDAFLRKNDGRFTVIQLVGMLRGIGSGMKYL--SDM 740 Query: 2434 TIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAGTP---EWMAPEVLRNEQ 2604 + VHRDL + N+LV+ N KV DFG+SR+ ++ +T G W APE + + Sbjct: 741 SYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAYRK 800 Query: 2605 SNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVASIIRD 2781 D++S+G+++WE+ + +P+ M+ V+ A+ + RL P + + ++ D Sbjct: 801 FTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIE-EGYRLPPPMDCPIALHQLMLD 859 Query: 2782 CWQKDPNLRPSFIQLTSYLKTLQR 2853 CWQK+ + RP F Q+ + L L R Sbjct: 860 CWQKERSDRPKFGQIVNMLDKLIR 883
>Q07496:EPHA4_CHICK Ephrin type-A receptor 4 precursor - Gallus gallus (Chicken)| Length = 986 Score = 119 bits (297), Expect = 1e-25 Identities = 79/264 (29%), Positives = 133/264 (50%), Gaps = 8/264 (3%) Frame = +1 Query: 2086 IDERIGIGSYGEVYHADWN---GTEVAVK-KFLDQEFYGDALEEFRCEVRIMRRLRHPNI 2253 I++ IG+G +GEV E+ V K L + +F E IM + HPNI Sbjct: 623 IEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQRRDFLSEASIMGQFDHPNI 682 Query: 2254 VLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGMNCLHTSVP 2433 + G VT+ + I++EY+ GSL + + + + + + M + GM L S Sbjct: 683 IHLEGVVTKCKPVMIITEYMENGSLDAFLRKNDGRFTVIQLVGMLRGIGSGMKYL--SDM 740 Query: 2434 TIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAGTP---EWMAPEVLRNEQ 2604 + VHRDL + N+LV+ N KV DFG+SR+ ++ +T G W APE + + Sbjct: 741 SYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAYRK 800 Query: 2605 SNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVASIIRD 2781 D++S+G+++WE+ + +P+ M+ V+ A+ + RL P + + ++ D Sbjct: 801 FTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIE-EGYRLPPPMDCPIALHQLMLD 859 Query: 2782 CWQKDPNLRPSFIQLTSYLKTLQR 2853 CWQK+ + RP F Q+ + L L R Sbjct: 860 CWQKERSDRPKFGQIVNMLDKLIR 883
>P16277:BLK_MOUSE Tyrosine-protein kinase BLK - Mus musculus (Mouse)| Length = 499 Score = 119 bits (297), Expect = 1e-25 Identities = 83/266 (31%), Positives = 136/266 (51%), Gaps = 4/266 (1%) Frame = +1 Query: 2056 ECEILWEDLVIDERIGIGSYGEVYHADW-NGTEVAVKKFLDQEFYGDALEEFRCEVRIMR 2232 E EI + L + ++G G +GEV+ + N +VA+K + +A F E +M+ Sbjct: 227 EWEIPRQSLKLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEA---FLGEANVMK 283 Query: 2233 RLRHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPN-CQIDEKRRIKMALDVARGM 2409 L+H +V VTR P + IV+EY+ RG L + ++ R I M+ VA GM Sbjct: 284 TLQHERLVRLYAVVTREP-IYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQVAEGM 342 Query: 2410 NCLHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAGTPEWMAPEV 2589 + +HRDL++ N+LV + K+ DFGL+R+ S + + + +W APE Sbjct: 343 AYIERM--NSIHRDLRAANILVSETLCCKIADFGLARIIDSEYTAQEGAKFPIKWTAPEA 400 Query: 2590 LRNEQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDP-IV 2763 + K D++SFGV+L + T R P+ GM+ +V+ ++ R+ P+ P + Sbjct: 401 IHFGVFTIKADVWSFGVLLMVIVTYGRVPYPGMSNPEVIRSLE-HGYRMPCPETCPPELY 459 Query: 2764 ASIIRDCWQKDPNLRPSFIQLTSYLK 2841 II +CW+ P RP+F L S L+ Sbjct: 460 NDIITECWRGRPEERPTFEFLQSVLE 485
>O73791:TIE2_DANRE Tyrosine-protein kinase receptor Tie-2 precursor - Danio rerio| (Zebrafish) (Brachydanio rerio) Length = 1116 Score = 118 bits (296), Expect = 1e-25 Identities = 95/307 (30%), Positives = 150/307 (48%), Gaps = 25/307 (8%) Frame = +1 Query: 2071 WEDLVIDERIGIGSYGEVYHA----DWNGTEVAVKKFLDQEFYGDALEEFRCEVRIMRRL 2238 W D+ + +G G++G+V A D + AVK+ D D +F E+ ++ RL Sbjct: 813 WSDIQFQDVLGEGNFGQVLKARIRKDGLRMDAAVKRMKDYASQDDH-RDFAGELEVLCRL 871 Query: 2239 R-HPNIVLFMGAVTRPPHLSIVSEYLPRGSL---------------YKIIHRPNCQIDEK 2370 H NI+ +GA +L + E+ P G+L + I HR + + Sbjct: 872 GPHKNIIHLLGACEHRGYLYLAIEFAPHGNLLDFLRKSRVLETDPAFAIAHRTASTLSSQ 931 Query: 2371 RRIKMALDVARGMNCLHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSK 2550 + + + DVARGM+ L S +HRDL + N+LV +N+ K+ DFGLSR + + K Sbjct: 932 QLLAFSADVARGMSYL--SQKQFIHRDLAARNVLVGENFVAKIADFGLSRGQE---VYVK 986 Query: 2551 STAG--TPEWMAPEVLRNEQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVG--AVG 2715 T G WMA E L D++S+GV+LWE+ +L P+ GM ++ +G Sbjct: 987 KTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEVVSLGGTPYCGMTCAELYEKLPLG 1046 Query: 2716 FQDRRLDIPKEVDPIVASIIRDCWQKDPNLRPSFIQLTSYLKTLQRLVIPSHQETASNHV 2895 F RL+ P D V +++ CW++ P RPSF Q+ L +L R++ ++T N Sbjct: 1047 F---RLEKPLNCDDEVYELMQQCWREKPFERPSFSQI---LLSLGRML--EERKTYVNTT 1098 Query: 2896 PYEISLY 2916 YE Y Sbjct: 1099 LYEKFTY 1105
>P35739:NTRK1_RAT High affinity nerve growth factor receptor precursor - Rattus| norvegicus (Rat) Length = 799 Score = 118 bits (296), Expect = 1e-25 Identities = 84/282 (29%), Positives = 145/282 (51%), Gaps = 24/282 (8%) Frame = +1 Query: 2074 EDLVIDERIGIGSYGEVYHA-------DWNGTEVAVKKFLDQEFYGDALEEFRCEVRIMR 2232 +D+++ +G G++G+V+ A D + VAVK +E +A ++F E ++ Sbjct: 511 QDIILKWELGEGAFGKVFLAECYNLLNDQDKMLVAVKAL--KETSENARQDFHREAELLT 568 Query: 2233 RLRHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKII--HRPNCQI------------DEK 2370 L+H +IV F G T L +V EY+ G L + + H P+ ++ Sbjct: 569 MLQHQHIVRFFGVCTEGGPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLG 628 Query: 2371 RRIKMALDVARGMNCLHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHST--FLS 2544 + + +A VA GM ++ + VHRDL + N LV VK+ DFG+SR +ST + Sbjct: 629 QLLAVASQVAAGM--VYLASLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRV 686 Query: 2545 SKSTAGTPEWMAPEVLRNEQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQ 2721 T WM PE + + + + D++SFGV+LWE+ T ++PW+ ++ + + + Q Sbjct: 687 GGRTMLPIRWMPPESILYRKFSTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIECI-TQ 745 Query: 2722 DRRLDIPKEVDPIVASIIRDCWQKDPNLRPSFIQLTSYLKTL 2847 R L+ P+ P V +I+R CWQ++P R S + + L+ L Sbjct: 746 GRELERPRACPPDVYAIMRGCWQREPQQRLSMKDVHARLQAL 787
>Q9FZ36:M3K2_ARATH Mitogen-activated protein kinase kinase kinase 2 - Arabidopsis| thaliana (Mouse-ear cress) Length = 651 Score = 118 bits (296), Expect = 1e-25 Identities = 79/258 (30%), Positives = 132/258 (51%), Gaps = 12/258 (4%) Frame = +1 Query: 2098 IGIGSYGEVY---HADWNGTEVAVKKFL------DQEFYGDALEEFRCEVRIMRRLRHPN 2250 IG G++G VY + D +G +AVK+ L +E ++E EV++++ L HPN Sbjct: 74 IGRGAFGTVYMGMNLD-SGELLAVKQVLITSNCASKEKTQAHIQELEEEVKLLKNLSHPN 132 Query: 2251 IVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGMNCLHTSV 2430 IV ++G V L+I+ E++P GS+ ++ + + R + G+ LH Sbjct: 133 IVRYLGTVREDETLNILLEFVPGGSISSLLEKFGAFPESVVRT-YTNQLLLGLEYLHNHA 191 Query: 2431 PTIVHRDLKSPNLLVDDNWTVKVCDFGLSR--LKHSTFLSSKSTAGTPEWMAPEVLRNEQ 2604 I+HRD+K N+LVD+ +K+ DFG S+ + +T +KS GTP WMAPEV+ Sbjct: 192 --IMHRDIKGANILVDNQGCIKLADFGASKQVAELATISGAKSMKGTPYWMAPEVILQTG 249 Query: 2605 SNEKCDIYSFGVILWELATLRKPW-HGMNQMQVVGAVGFQDRRLDIPKEVDPIVASIIRD 2781 + DI+S G + E+ T + PW ++ + +G IP + + Sbjct: 250 HSFSADIWSVGCTVIEMVTGKAPWSQQYKEIAAIFHIGTTKSHPPIPDNISSDANDFLLK 309 Query: 2782 CWQKDPNLRPSFIQLTSY 2835 C Q++PNLRP+ +L + Sbjct: 310 CLQQEPNLRPTASELLKH 327
>Q03526:ITK_MOUSE Tyrosine-protein kinase ITK/TSK - Mus musculus (Mouse)| Length = 625 Score = 118 bits (296), Expect = 1e-25 Identities = 81/259 (31%), Positives = 128/259 (49%), Gaps = 5/259 (1%) Frame = +1 Query: 2077 DLVIDERIGIGSYGEVYHADW-NGTEVAVKKFLDQEFYGDALEEFRCEVRIMRRLRHPNI 2253 +L + IG G +G V+ W N +VA+K + + E+F E +M +L HP + Sbjct: 367 ELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIQEGAM---SEEDFIEEAEVMMKLSHPKL 423 Query: 2254 VLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDEKRRIKMALDVARGMNCLHTSVP 2433 V G + +V E++ G L + + + M LDV GM L + Sbjct: 424 VQLYGVCLEQAPICLVFEFMEHGCLSDYLRSQRGLFAAETLLGMCLDVCEGMAYLEKAC- 482 Query: 2434 TIVHRDLKSPNLLVDDNWTVKVCDFGLSR-LKHSTFLSSKSTAGTPEWMAPEVLRNEQSN 2610 ++HRDL + N LV +N +KV DFG++R + + SS T +W +PEV + + Sbjct: 483 -VIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYS 541 Query: 2611 EKCDIYSFGVILWELATLRK-PWHGMNQMQVVG--AVGFQDRRLDIPKEVDPIVASIIRD 2781 K D++SFGV++WE+ + K P+ + +VV + GF RL P+ V I+ Sbjct: 542 SKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGF---RLYKPRLASCHVYQIMNH 598 Query: 2782 CWQKDPNLRPSFIQLTSYL 2838 CW++ P RP F QL S L Sbjct: 599 CWKEKPEDRPPFSQLLSQL 617
>P08631:HCK_HUMAN Tyrosine-protein kinase HCK - Homo sapiens (Human)| Length = 526 Score = 118 bits (296), Expect = 1e-25 Identities = 79/263 (30%), Positives = 138/263 (52%), Gaps = 4/263 (1%) Frame = +1 Query: 2062 EILWEDLVIDERIGIGSYGEVYHADWNG-TEVAVKKFLDQEFYGDALEEFRCEVRIMRRL 2238 EI E L +++++G G +GEV+ A +N T+VAVK ++E F E +M+ L Sbjct: 256 EIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSM---SVEAFLAEANVMKTL 312 Query: 2239 RHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYKIIHRPNCQIDE-KRRIKMALDVARGMNC 2415 +H +V VT+ P + I++E++ +GSL + + I + +A GM Sbjct: 313 QHDKLVKLHAVVTKEP-IYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAF 371 Query: 2416 LHTSVPTIVHRDLKSPNLLVDDNWTVKVCDFGLSRLKHSTFLSSKSTAGTP-EWMAPEVL 2592 + +HRDL++ N+LV + K+ DFGL+R+ +++ A P +W APE + Sbjct: 372 IEQR--NYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAI 429 Query: 2593 RNEQSNEKCDIYSFGVILWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVAS 2769 K D++SFG++L E+ T R P+ GM+ +V+ A+ + R+ P+ + + Sbjct: 430 NFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALE-RGYRMPRPENCPEELYN 488 Query: 2770 IIRDCWQKDPNLRPSFIQLTSYL 2838 I+ CW+ P RP+F + S L Sbjct: 489 IMMRCWKNRPEERPTFEYIQSVL 511
>P22455:FGFR4_HUMAN Fibroblast growth factor receptor 4 precursor - Homo sapiens (Human)| Length = 802 Score = 118 bits (296), Expect = 1e-25 Identities = 96/330 (29%), Positives = 155/330 (46%), Gaps = 32/330 (9%) Frame = +1 Query: 2017 GSSKVDLVLDEVSECEILWE----DLVIDERIGIGSYGEVYHADWNGTE---------VA 2157 G +DL LD LWE LV+ + +G G +G+V A+ G + VA Sbjct: 448 GLVSLDLPLDP------LWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVA 501 Query: 2158 VKKFLDQEFYGDALEEFRCEVRIMRRL-RHPNIVLFMGAVTRPPHLSIVSEYLPRGSLYK 2334 VK D D L + E+ +M+ + RH NI+ +G T+ L ++ E +G+L + Sbjct: 502 VKMLKDNASDKD-LADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLRE 560 Query: 2335 IIHR-----PNCQIDEKRR----------IKMALDVARGMNCLHTSVPTIVHRDLKSPNL 2469 + P+ D R + A VARGM L + +HRDL + N+ Sbjct: 561 FLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESR--KCIHRDLAARNV 618 Query: 2470 LVDDNWTVKVCDFGLSR-LKHSTFLSSKSTAGTP-EWMAPEVLRNEQSNEKCDIYSFGVI 2643 LV ++ +K+ DFGL+R + H + S P +WMAPE L + + D++SFG++ Sbjct: 619 LVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGIL 678 Query: 2644 LWELATL-RKPWHGMNQMQVVGAVGFQDRRLDIPKEVDPIVASIIRDCWQKDPNLRPSFI 2820 LWE+ TL P+ G+ ++ + + R+D P P + ++R+CW P+ RP+F Sbjct: 679 LWEIFTLGGSPYPGIPVEELFSLLR-EGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFK 737 Query: 2821 QLTSYLKTLQRLVIPSHQETASNHVPYEIS 2910 QL L + V + + PY S Sbjct: 738 QLVEALDKVLLAVSEEYLDLRLTFGPYSPS 767 Database: uniprot_sprot.fasta.out Posted date: Jul 19, 2007 5:58 PM Number of letters in database: 100,686,439 Number of sequences in database: 274,295 Lambda K H 0.318 0.134 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 274295 Number of Hits to DB: 607,703,963 Number of extensions: 13924429 Number of successful extensions: 43709 Number of sequences better than 10.0: 2525 Number of HSP's gapped: 39640 Number of HSP's successfully gapped: 2633 Length of query: 1098 Length of database: 100,686,439 Length adjustment: 124 Effective length of query: 974 Effective length of database: 66,673,859 Effective search space: 64940338666 Effective search space used: 64940338666 Neighboring words threshold: 12 Window for multiple hits: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)
