>Q86VP6:CAND1_HUMAN Cullin-associated NEDD8-dissociated protein 1 - Homo sapiens (Human)|
          Length = 1230
 Score =  882 bits (2279), Expect = 0.0
 Identities = 502/1238 (40%), Positives = 750/1238 (60%), Gaps = 17/1238 (1%)
 Frame = +2

Query: 44   VAMANTNITGILEKMTGKDKDYRYMATSDLLSELNKESFKADQDLESKLTNIVLQQLEDA 223
            +A A+ +I+ +LEKMT  DKD+R+MAT+DL++EL K+S K D D E K+  ++L+ LED 
Sbjct: 1    MASASYHISNLLEKMTSSDKDFRFMATNDLMTELQKDSIKLDDDSERKVVKMILKLLEDK 60

Query: 224  SGDVSGLAVKCLAPLVKKVSEERVVEMTDKLCDKLLNGKDQHRDTASIALKAVIVEVTTA 403
            +G+V  LAVKCL PLV KV E +V  + D LC  +L+ K+Q RD +SI LK VI E+  A
Sbjct: 61   NGEVQNLAVKCLGPLVSKVKEYQVETIVDTLCTNMLSDKEQLRDISSIGLKTVIGELPPA 120

Query: 404  S----LSEKILVSLAPQLIKGVTSGKSAEIKCECLDILGDVLHRFGNVITKDHAYMLTAL 571
            S    L+  +   +  +L   +   +   ++ E LDI+ D+L R G ++   H  +LT L
Sbjct: 121  SSGSALAANVCKKITGRLTSAIAKQEDVSVQLEALDIMADMLSRQGGLLVNFHPSILTCL 180

Query: 572  LAQLSSTQASVRKKSVSCIASLAPCLSDDLLAKGTLEVVKLLKNRKAKSD---ITRTNIQ 742
            L QL+S + +VRK+++  +  L     + +     +++++ L +  +K+D    TRT IQ
Sbjct: 181  LPQLTSPRLAVRKRTIIALGHLVMSCGNIVF----VDLIEHLLSELSKNDSMSTTRTYIQ 236

Query: 743  MIGALSRSVGYRFGPHLAEAVPLLINYCTSASENDEELREYSLQALESFMLRCPRDISPY 922
             I A+SR  G+R G +L + +PL++ +C   + +D+ELREY +QA ESF+ RCP+++ P+
Sbjct: 237  CIAAISRQAGHRIGEYLEKIIPLVVKFC---NVDDDELREYCIQAFESFVRRCPKEVYPH 293

Query: 923  CEGILNLALEYVSYDPNFXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX---ASWKVRRAS 1093
               I+N+ L+Y++YDPN+                                  SWKVRRA+
Sbjct: 294  VSTIINICLKYLTYDPNYNYDDEDEDENAMDADGGDDDDQGSDDEYSDDDDMSWKVRRAA 353

Query: 1094 AKCISAIIVSRPQMLSKMYQEACPKLVDRFREREENVKMDIFNTFIELLRQTGNVTKGQG 1273
            AKC+ A++ +R +ML + Y+   P L+ RF+EREENVK D+F+ ++ LL+QT  V     
Sbjct: 354  AKCLDAVVSTRHEMLPEFYKTVSPALISRFKEREENVKADVFHAYLSLLKQTRPVQSWLC 413

Query: 1274 DIDE----SSPRWLLKQEVPKIVKSINRQLREKSIKTKVGAFSVLKELVVVLPDCLADQF 1441
            D D      +P  +L+ +VP IVK++++Q++EKS+KT+   F++L ELV VLP  L    
Sbjct: 414  DPDAMEQGETPLTMLQSQVPNIVKALHKQMKEKSVKTRQCCFNMLTELVNVLPGALTQHI 473

Query: 1442 GSLVPGIEKALNDKSSTSNLKIEALAFTRIVMASHSPSVFHPYIQALSGPILSAIGDRYY 1621
              LVPGI  +LNDKSS+SNLKI+AL+   +++ +HSP VFHP++QAL  P+++ +GD +Y
Sbjct: 474  PVLVPGIIFSLNDKSSSSNLKIDALSCLYVILCNHSPQVFHPHVQALVPPVVACVGDPFY 533

Query: 1622 KVTAEALRVCGELVRVLRPNFQAHSIDFRPYISPIYKAILARLANQDQDQEVKECAISCM 1801
            K+T+EAL V  +LV+V+RP  Q  S D  PYI  ++   + RL   D DQEVKE AISCM
Sbjct: 534  KITSEALLVTQQLVKVIRPLDQPSSFDATPYIKDLFTCTIKRLKAADIDQEVKERAISCM 593

Query: 1802 SLVIATFGDGLQRELPACLPILVDRMGNEITRLTAVKAFAVIANSPLRIDLSCVLDHVVS 1981
              +I   GD L  +LP  L I ++R+ NEITRLT VKA  +IA SPL+IDL  VL   V 
Sbjct: 594  GQIICNLGDNLGSDLPNTLQIFLERLKNEITRLTTVKALTLIAGSPLKIDLRPVLGEGVP 653

Query: 1982 ELTAFLRKANRALRQATLGTLNSLVVTYGSQIGSSSYETILTELSTLISDVDLHMAALAL 2161
             L +FLRK  RAL+  TL  L+ L+  Y   + ++  + +L EL  LIS+ D+H++ +A+
Sbjct: 654  ILASFLRKNQRALKLGTLSALDILIKNYSDSLTAAMIDAVLDELPPLISESDMHVSQMAI 713

Query: 2162 ELCCTI-MVDRRSVKNVGLAVIHKVLPEALTLIRSXXXXXXXXXXXXXXXXXXXXSA--N 2332
                T+  V   S+  +       +L E + L+RS                    +   N
Sbjct: 714  SFLTTLAKVYPSSLSKIS----GSILNELIGLVRSPLLQGGALSAMLDFFQALVVTGTNN 769

Query: 2333 ISFETLLNSLISTAKPSQSGGLSKQALFSIAQCVAVLCLAAGDKKCASTIEMLKGILNDD 2512
            + +  LL  L        +    KQ+ +SIA+CVA L  A   +  A   + ++ + N  
Sbjct: 770  LGYMDLLRMLTGPVYSQSTALTHKQSYYSIAKCVAALTRACPKEGPAVVGQFIQDVKN-S 828

Query: 2513 SSTNSAKQHMALLCLGEIGRRKDLSNHDQIENIVIESFQSPFEEIKSAASYALGNIAVGN 2692
             ST+S +  +ALL LGE+G   DLS   +++++++E+F SP EE+KSAASYALG+I+VGN
Sbjct: 829  RSTDSIRL-LALLSLGEVGHHIDLSGQLELKSVILEAFSSPSEEVKSAASYALGSISVGN 887

Query: 2693 LSKYLPFILDQIDNQQKKQYLLLHSLKEVIARQSVDHTGQSELQDSNILKILALLFNHCE 2872
            L +YLPF+L +I +Q K+QYLLLHSLKE+I+  SV   G     ++    I ALL  HCE
Sbjct: 888  LPEYLPFVLQEITSQPKRQYLLLHSLKEIISSASV--VGLKPYVEN----IWALLLKHCE 941

Query: 2873 SEEEGVRNVVAECLGKIALIEPNKLIPALKERTSSPAANTRATVAIAIKYSIVERTGKID 3052
              EEG RNVVAECLGK+ LI+P  L+P LK    S ++  R++V  A+K++I +    ID
Sbjct: 942  CAEEGTRNVVAECLGKLTLIDPETLLPRLKGYLISGSSYARSSVVTAVKFTISDHPQPID 1001

Query: 3053 AILYSEISTFLMLIKDSDRHVRRAAVLALSTAAHNKPNLIKRXXXXXXXXXYDQTVVKQE 3232
             +L + I  FL  ++D D +VRR A++  ++AAHNKP+LI+          Y++T V++E
Sbjct: 1002 PLLKNCIGDFLKTLEDPDLNVRRVALVTFNSAAHNKPSLIRDLLDTVLPHLYNETKVRKE 1061

Query: 3233 LIRTVDLGPFKHVVDDGLELRKAAFECVDTLLDSCLDQVNPSAFIVPFLLSGLGDHYDVK 3412
            LIR V++GPFKH VDDGL++RKAAFEC+ TLLDSCLD+++   F+   +  GL DHYD+K
Sbjct: 1062 LIREVEMGPFKHTVDDGLDIRKAAFECMYTLLDSCLDRLDIFEFL-NHVEDGLKDHYDIK 1120

Query: 3413 MPCHLILSKLADKCPSAVLAVLDSLVEPLEKTIVHKPKGDAVKQEIDRNEGXXXXXXXXX 3592
            M   L+L +L+  CPSAVL  LD LVEPL  T   K K ++VKQE ++ +          
Sbjct: 1121 MLTFLMLVRLSTLCPSAVLQRLDRLVEPLRATCTTKVKANSVKQEFEKQDELKRSAMRAV 1180

Query: 3593 XXXXXXXGSDYSMKLKKLMSKITSTSSLAEKYNSVRSE 3706
                    ++ S  + +  S+I+S   LA  + S++ +
Sbjct: 1181 AALLTIPEAEKSPLMSEFQSQISSNPELAAIFESIQKD 1218

>P97536:CAND1_RAT Cullin-associated NEDD8-dissociated protein 1 - Rattus norvegicus|
            (Rat)
          Length = 1230

 Score =  879 bits (2270), Expect = 0.0
 Identities = 501/1238 (40%), Positives = 749/1238 (60%), Gaps = 17/1238 (1%)
 Frame = +2

Query: 44   VAMANTNITGILEKMTGKDKDYRYMATSDLLSELNKESFKADQDLESKLTNIVLQQLEDA 223
            +A A+ +I+ +LEKMT  DKD+R+MAT+DL++EL K+S K D D E K+  ++L+ LED 
Sbjct: 1    MASASYHISNLLEKMTSSDKDFRFMATNDLMTELQKDSIKLDDDSERKVVKMILKLLEDK 60

Query: 224  SGDVSGLAVKCLAPLVKKVSEERVVEMTDKLCDKLLNGKDQHRDTASIALKAVIVEVTTA 403
            +G+V  LAVKCL PLV KV E +V  + D LC  +L+ K+Q RD +SI LK VI E+  A
Sbjct: 61   NGEVQNLAVKCLGPLVSKVKEYQVETIVDTLCTNMLSDKEQLRDISSIGLKTVIGELPPA 120

Query: 404  S----LSEKILVSLAPQLIKGVTSGKSAEIKCECLDILGDVLHRFGNVITKDHAYMLTAL 571
            S    L+  +   +  +L   +   +   ++ E LDI+ D+L R G ++   H  +LT L
Sbjct: 121  SSGSALAANVCKKITGRLTSAIAKQEDVSVQLEALDIMADMLSRQGGLLVNFHPSILTCL 180

Query: 572  LAQLSSTQASVRKKSVSCIASLAPCLSDDLLAKGTLEVVKLLKNRKAKSD---ITRTNIQ 742
            L QL+S + +VRK+++  +  L     + +     +++++ L +  +K+D    TRT IQ
Sbjct: 181  LPQLTSPRLAVRKRTIIALGHLVMSCGNIVF----VDLIEHLLSELSKNDSMSTTRTYIQ 236

Query: 743  MIGALSRSVGYRFGPHLAEAVPLLINYCTSASENDEELREYSLQALESFMLRCPRDISPY 922
             I A+SR  G+R G +L + +PL++ +C   + +D+ELREY +QA ESF+ RCP+++ P+
Sbjct: 237  CIAAISRQAGHRIGEYLEKIIPLVVKFC---NVDDDELREYCIQAFESFVRRCPKEVYPH 293

Query: 923  CEGILNLALEYVSYDPNFXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX---ASWKVRRAS 1093
               I+N+ L+Y++YDPN+                                  SWKVRRA+
Sbjct: 294  VSTIINICLKYLTYDPNYNYDDEDEDENAMDADGGDDDDQGSDDEYSDDDDMSWKVRRAA 353

Query: 1094 AKCISAIIVSRPQMLSKMYQEACPKLVDRFREREENVKMDIFNTFIELLRQTGNVTKGQG 1273
            AKC+ A++ +R +ML + Y+   P L+ RF+EREENVK D+F+ ++ LL+QT  V     
Sbjct: 354  AKCLDAVVSTRHEMLPEFYKTVSPALISRFKEREENVKADVFHAYLSLLKQTRPVQSWLC 413

Query: 1274 DIDE----SSPRWLLKQEVPKIVKSINRQLREKSIKTKVGAFSVLKELVVVLPDCLADQF 1441
            D D      +P  +L+ +VP IVK++++Q++EKS+KT+   F++L ELV VLP  L    
Sbjct: 414  DPDAMEQGETPLTMLQSQVPNIVKALHKQMKEKSVKTRQCCFNMLTELVNVLPGALTQHI 473

Query: 1442 GSLVPGIEKALNDKSSTSNLKIEALAFTRIVMASHSPSVFHPYIQALSGPILSAIGDRYY 1621
              LVPGI  +LNDKSS+SNLKI+AL+   +++ +HSP VFHP++QAL  P+++ +GD +Y
Sbjct: 474  PVLVPGIIFSLNDKSSSSNLKIDALSCLYVILCNHSPQVFHPHVQALVPPVVACVGDPFY 533

Query: 1622 KVTAEALRVCGELVRVLRPNFQAHSIDFRPYISPIYKAILARLANQDQDQEVKECAISCM 1801
            K+T+EAL V  +LV+V+RP  Q  S D  PYI  ++   + RL   D DQEVKE AISCM
Sbjct: 534  KITSEALLVTQQLVKVIRPLDQPSSFDATPYIKDLFTCTIKRLKAADIDQEVKERAISCM 593

Query: 1802 SLVIATFGDGLQRELPACLPILVDRMGNEITRLTAVKAFAVIANSPLRIDLSCVLDHVVS 1981
              +I   GD L  +L   L I ++R+ NEITRLT VKA  +IA SPL+IDL  VL   V 
Sbjct: 594  GQIICNLGDNLGPDLSNTLQIFLERLKNEITRLTTVKALTLIAGSPLKIDLRPVLGEGVP 653

Query: 1982 ELTAFLRKANRALRQATLGTLNSLVVTYGSQIGSSSYETILTELSTLISDVDLHMAALAL 2161
             L +FLRK  RAL+  TL  L+ L+  Y   + ++  + +L EL  LIS+ D+H++ +A+
Sbjct: 654  ILASFLRKNQRALKLGTLSALDILIKNYSDSLTAAMIDAVLDELPPLISESDMHVSQMAI 713

Query: 2162 ELCCTI-MVDRRSVKNVGLAVIHKVLPEALTLIRSXXXXXXXXXXXXXXXXXXXXSA--N 2332
                T+  V   S+  +       +L E + L+RS                    +   N
Sbjct: 714  SFLTTLAKVYPSSLSKIS----GSILNELIGLVRSPLLQGGALSAMLDFFQALVVTGTNN 769

Query: 2333 ISFETLLNSLISTAKPSQSGGLSKQALFSIAQCVAVLCLAAGDKKCASTIEMLKGILNDD 2512
            + +  LL  L        +    KQ+ +SIA+CVA L  A   +  A   + ++ + N  
Sbjct: 770  LGYMDLLRMLTGPVYSQSTALTHKQSYYSIAKCVAALTRACPKEGPAVVGQFIQDVKN-S 828

Query: 2513 SSTNSAKQHMALLCLGEIGRRKDLSNHDQIENIVIESFQSPFEEIKSAASYALGNIAVGN 2692
             ST+S +  +ALL LGE+G   DLS   +++++++E+F SP EE+KSAASYALG+I+VGN
Sbjct: 829  RSTDSIRL-LALLSLGEVGHHIDLSGQLELKSVILEAFSSPSEEVKSAASYALGSISVGN 887

Query: 2693 LSKYLPFILDQIDNQQKKQYLLLHSLKEVIARQSVDHTGQSELQDSNILKILALLFNHCE 2872
            L +YLPF+L +I +Q K+QYLLLHSLKE+I+  SV   G     ++    I ALL  HCE
Sbjct: 888  LPEYLPFVLQEITSQPKRQYLLLHSLKEIISSASV--VGLKPYVEN----IWALLLKHCE 941

Query: 2873 SEEEGVRNVVAECLGKIALIEPNKLIPALKERTSSPAANTRATVAIAIKYSIVERTGKID 3052
              EEG RNVVAECLGK+ LI+P  L+P LK    S ++  R++V  A+K++I +    ID
Sbjct: 942  CAEEGTRNVVAECLGKLTLIDPETLLPRLKGYLISGSSYARSSVVTAVKFTISDHPQPID 1001

Query: 3053 AILYSEISTFLMLIKDSDRHVRRAAVLALSTAAHNKPNLIKRXXXXXXXXXYDQTVVKQE 3232
             +L + I  FL  ++D D +VRR A++  ++AAHNKP+LI+          Y++T V++E
Sbjct: 1002 PLLKNCIGDFLKTLEDPDLNVRRVALVTFNSAAHNKPSLIRDLLDSVLPHLYNETKVRKE 1061

Query: 3233 LIRTVDLGPFKHVVDDGLELRKAAFECVDTLLDSCLDQVNPSAFIVPFLLSGLGDHYDVK 3412
            LIR V++GPFKH VDDGL++RKAAFEC+ TLLDSCLD+++   F+   +  GL DHYD+K
Sbjct: 1062 LIREVEMGPFKHTVDDGLDIRKAAFECMYTLLDSCLDRLDIFEFL-NHVEDGLKDHYDIK 1120

Query: 3413 MPCHLILSKLADKCPSAVLAVLDSLVEPLEKTIVHKPKGDAVKQEIDRNEGXXXXXXXXX 3592
            M   L+L +L+  CPSAVL  LD LVEPL  T   K K ++VKQE ++ +          
Sbjct: 1121 MLTFLMLVRLSTLCPSAVLQRLDRLVEPLRATCTTKVKANSVKQEFEKQDELKRSAMRAV 1180

Query: 3593 XXXXXXXGSDYSMKLKKLMSKITSTSSLAEKYNSVRSE 3706
                    ++ S  + +  S+I+S   LA  + S++ +
Sbjct: 1181 AALLTIPEAEKSPLMSEFQSQISSNPELAAIFESIQKD 1218

>Q6ZQ38:CAND1_MOUSE Cullin-associated NEDD8-dissociated protein 1 - Mus musculus (Mouse)|
          Length = 1230

 Score =  878 bits (2268), Expect = 0.0
 Identities = 501/1238 (40%), Positives = 749/1238 (60%), Gaps = 17/1238 (1%)
 Frame = +2

Query: 44   VAMANTNITGILEKMTGKDKDYRYMATSDLLSELNKESFKADQDLESKLTNIVLQQLEDA 223
            +A A+ +I+ +LEKMT  DKD+R+MAT+DL++EL K+S K D D E K+  ++L+ LED 
Sbjct: 1    MASASYHISNLLEKMTSSDKDFRFMATNDLMTELQKDSIKLDDDSERKVVKMILRLLEDK 60

Query: 224  SGDVSGLAVKCLAPLVKKVSEERVVEMTDKLCDKLLNGKDQHRDTASIALKAVIVEVTTA 403
            +G+V  LAVKCL PLV KV E +V  + D LC  +L+ K+Q RD +SI LK VI E+  A
Sbjct: 61   NGEVQNLAVKCLGPLVSKVKEYQVETIVDTLCTNMLSDKEQLRDISSIGLKTVIGELPPA 120

Query: 404  S----LSEKILVSLAPQLIKGVTSGKSAEIKCECLDILGDVLHRFGNVITKDHAYMLTAL 571
            S    L+  +   +  +L   +   +   ++ E LDI+ D+L R G ++   H  +LT L
Sbjct: 121  SSGSALAANVCKKITGRLTSAIAKQEDVSVQLEALDIMADMLSRQGGLLVNFHPSILTCL 180

Query: 572  LAQLSSTQASVRKKSVSCIASLAPCLSDDLLAKGTLEVVKLLKNRKAKSD---ITRTNIQ 742
            L QL+S + +VRK+++  +  L     + +     +++++ L +  +K+D    TRT IQ
Sbjct: 181  LPQLTSPRLAVRKRTIIALGHLVMSCGNIVF----VDLIEHLLSELSKNDSMSTTRTYIQ 236

Query: 743  MIGALSRSVGYRFGPHLAEAVPLLINYCTSASENDEELREYSLQALESFMLRCPRDISPY 922
             I A+SR  G+R G +L + +PL++ +C   + +D+ELREY +QA ESF+ RCP+++ P+
Sbjct: 237  CIAAISRQAGHRIGEYLEKIIPLVVKFC---NVDDDELREYCIQAFESFVRRCPKEVYPH 293

Query: 923  CEGILNLALEYVSYDPNFXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX---ASWKVRRAS 1093
               I+N+ L+Y++YDPN+                                  SWKVRRA+
Sbjct: 294  VSTIINICLKYLTYDPNYNYDDEDEDENAMDADGGDDDDQGSDDEYSDDDDMSWKVRRAA 353

Query: 1094 AKCISAIIVSRPQMLSKMYQEACPKLVDRFREREENVKMDIFNTFIELLRQTGNVTKGQG 1273
            AKC+ A++ +R +ML + Y+   P L+ RF+EREENVK D+F+ ++ LL+QT  V     
Sbjct: 354  AKCLDAVVSTRHEMLPEFYKTVSPALIARFKEREENVKADVFHAYLSLLKQTRPVQSWLC 413

Query: 1274 DIDE----SSPRWLLKQEVPKIVKSINRQLREKSIKTKVGAFSVLKELVVVLPDCLADQF 1441
            D D      +P  +L+ +VP IVK++++Q++EKS+KT+   F++L ELV VLP  L    
Sbjct: 414  DPDAMEQGDTPLTMLQSQVPNIVKALHKQMKEKSVKTRQCCFNMLTELVNVLPGALTQHI 473

Query: 1442 GSLVPGIEKALNDKSSTSNLKIEALAFTRIVMASHSPSVFHPYIQALSGPILSAIGDRYY 1621
              LVPGI  +LNDKSS+SNLKI+AL+   +++ +HSP VFHP++QAL  P+++ +GD +Y
Sbjct: 474  PVLVPGIIFSLNDKSSSSNLKIDALSCLYVILCNHSPQVFHPHVQALVPPVVACVGDPFY 533

Query: 1622 KVTAEALRVCGELVRVLRPNFQAHSIDFRPYISPIYKAILARLANQDQDQEVKECAISCM 1801
            K+T+EAL V  +LV+V+RP  Q  S D  PYI  ++   + RL   D DQEVKE AISCM
Sbjct: 534  KITSEALLVTQQLVKVIRPLDQPSSFDATPYIKDLFTCTIKRLKAADIDQEVKERAISCM 593

Query: 1802 SLVIATFGDGLQRELPACLPILVDRMGNEITRLTAVKAFAVIANSPLRIDLSCVLDHVVS 1981
              +I   GD L  +L   L I ++R+ NEITRLT VKA  +IA SPL+IDL  VL   V 
Sbjct: 594  GQIICNLGDNLGPDLSNTLQIFLERLKNEITRLTTVKALTLIAGSPLKIDLRPVLGEGVP 653

Query: 1982 ELTAFLRKANRALRQATLGTLNSLVVTYGSQIGSSSYETILTELSTLISDVDLHMAALAL 2161
             L +FLRK  RAL+  TL  L+ L+  Y   + ++  + +L EL  LIS+ D+H++ +A+
Sbjct: 654  ILASFLRKNQRALKLGTLSALDILIKNYSDSLTAAMIDAVLDELPPLISESDMHVSQMAI 713

Query: 2162 ELCCTI-MVDRRSVKNVGLAVIHKVLPEALTLIRSXXXXXXXXXXXXXXXXXXXXSA--N 2332
                T+  V   S+  +       +L E + L+RS                    +   N
Sbjct: 714  SFLTTLAKVYPSSLSKIS----GSILNELIGLVRSPLLQGGALSAMLDFFQALVVTGTNN 769

Query: 2333 ISFETLLNSLISTAKPSQSGGLSKQALFSIAQCVAVLCLAAGDKKCASTIEMLKGILNDD 2512
            + +  LL  L        +    KQ+ +SIA+CVA L  A   +  A   + ++ + N  
Sbjct: 770  LGYMDLLRMLTGPVYSQSTALTHKQSYYSIAKCVAALTRACPKEGPAVVGQFIQDVKN-S 828

Query: 2513 SSTNSAKQHMALLCLGEIGRRKDLSNHDQIENIVIESFQSPFEEIKSAASYALGNIAVGN 2692
             ST+S +  +ALL LGE+G   DLS   +++++++E+F SP EE+KSAASYALG+I+VGN
Sbjct: 829  RSTDSIRL-LALLSLGEVGHHIDLSGQLELKSVILEAFSSPSEEVKSAASYALGSISVGN 887

Query: 2693 LSKYLPFILDQIDNQQKKQYLLLHSLKEVIARQSVDHTGQSELQDSNILKILALLFNHCE 2872
            L +YLPF+L +I +Q K+QYLLLHSLKE+I+  SV   G     ++    I ALL  HCE
Sbjct: 888  LPEYLPFVLQEITSQPKRQYLLLHSLKEIISSASV--AGLKPYVEN----IWALLLKHCE 941

Query: 2873 SEEEGVRNVVAECLGKIALIEPNKLIPALKERTSSPAANTRATVAIAIKYSIVERTGKID 3052
              EEG RNVVAECLGK+ LI+P  L+P LK    S ++  R++V  A+K++I +    ID
Sbjct: 942  CAEEGTRNVVAECLGKLTLIDPETLLPRLKGYLISGSSYARSSVVTAVKFTISDHPQPID 1001

Query: 3053 AILYSEISTFLMLIKDSDRHVRRAAVLALSTAAHNKPNLIKRXXXXXXXXXYDQTVVKQE 3232
             +L + I  FL  ++D D +VRR A++  ++AAHNKP+LI+          Y++T V++E
Sbjct: 1002 PLLKNCIGDFLKTLEDPDLNVRRVALVTFNSAAHNKPSLIRDLLDSVLPHLYNETKVRKE 1061

Query: 3233 LIRTVDLGPFKHVVDDGLELRKAAFECVDTLLDSCLDQVNPSAFIVPFLLSGLGDHYDVK 3412
            LIR V++GPFKH VDDGL++RKAAFEC+ TLLDSCLD+++   F+   +  GL DHYD+K
Sbjct: 1062 LIREVEMGPFKHTVDDGLDIRKAAFECMYTLLDSCLDRLDIFEFL-NHVEDGLKDHYDIK 1120

Query: 3413 MPCHLILSKLADKCPSAVLAVLDSLVEPLEKTIVHKPKGDAVKQEIDRNEGXXXXXXXXX 3592
            M   L+L +L+  CPSAVL  LD LVEPL  T   K K ++VKQE ++ +          
Sbjct: 1121 MLTFLMLVRLSTLCPSAVLQRLDRLVEPLRATCTTKVKANSVKQEFEKQDELKRSAMRAV 1180

Query: 3593 XXXXXXXGSDYSMKLKKLMSKITSTSSLAEKYNSVRSE 3706
                    ++ S  + +  S+I+S   LA  + S++ +
Sbjct: 1181 AALLTIPEAEKSPLMSEFQSQISSNPELAAIFESIQKD 1218

>Q5R6L5:CAND1_PONPY Cullin-associated NEDD8-dissociated protein 1 - Pongo pygmaeus|
            (Orangutan)
          Length = 1230

 Score =  875 bits (2260), Expect = 0.0
 Identities = 497/1235 (40%), Positives = 744/1235 (60%), Gaps = 14/1235 (1%)
 Frame = +2

Query: 44   VAMANTNITGILEKMTGKDKDYRYMATSDLLSELNKESFKADQDLESKLTNIVLQQLEDA 223
            +A A+ +I+ +LEKMT   KD+R+MAT+DL++EL K+S K D D E K+  ++L+  ED 
Sbjct: 1    MASASYHISNLLEKMTSSGKDFRFMATNDLMTELQKDSIKLDDDSERKVVKMILKLQEDK 60

Query: 224  SGDVSGLAVKCLAPLVKKVSEERVVEMTDKLCDKLLNGKDQHRDTASIALKAVIVEVTTA 403
            +G+V  LAVKCL PLV KV E +V  + D LC  +L+ K+Q RD +SI LK VI E+  A
Sbjct: 61   NGEVQNLAVKCLGPLVSKVKEYQVETIVDTLCTNMLSDKEQLRDISSIGLKTVIGELPPA 120

Query: 404  S----LSEKILVSLAPQLIKGVTSGKSAEIKCECLDILGDVLHRFGNVITKDHAYMLTAL 571
            S    L+  +   +  +L   +   +   ++ E LDI+ D+L R G ++   H  +LT L
Sbjct: 121  SSGSALAANVCKKITGRLTSAIAKQEDVSVQLEALDIMADMLSRQGGLLVNFHPSILTCL 180

Query: 572  LAQLSSTQASVRKKSVSCIASLAPCLSDDLLAKGTLEVVKLLKNRKAKSDITRTNIQMIG 751
            L QL+S + +VRK+++  +  L     + ++  G +E +    ++      TRT IQ I 
Sbjct: 181  LPQLTSPRLAVRKRTIIALGHLVMSCGN-IVFVGLIEHLLSELSKNDSMSTTRTYIQCIA 239

Query: 752  ALSRSVGYRFGPHLAEAVPLLINYCTSASENDEELREYSLQALESFMLRCPRDISPYCEG 931
            A+SR  G+R G +L + +PL++ +C   + +D+ELREY +QA ESF+ RCP+++ P+   
Sbjct: 240  AISRQAGHRIGEYLEKIIPLVVKFC---NVDDDELREYCIQAFESFVRRCPKEVYPHVST 296

Query: 932  ILNLALEYVSYDPNFXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX---ASWKVRRASAKC 1102
            I+N+ L+Y++YDPN+                                  SWKVRRA+AKC
Sbjct: 297  IINICLKYLTYDPNYNYDDEDEDENAMDADGGDDDDQGSDDEYSDDGDMSWKVRRAAAKC 356

Query: 1103 ISAIIVSRPQMLSKMYQEACPKLVDRFREREENVKMDIFNTFIELLRQTGNVTKGQGDID 1282
            + A++ +R +ML + Y+   P L+ RF+EREENVK D+F+ ++ LL+QT  V     D D
Sbjct: 357  LDAVVSTRHEMLPEFYKTVSPALISRFKEREENVKADVFHAYLSLLKQTRPVQSWLCDPD 416

Query: 1283 E----SSPRWLLKQEVPKIVKSINRQLREKSIKTKVGAFSVLKELVVVLPDCLADQFGSL 1450
                  +P  +L+ +VP IVK++++Q++EKS+KT+   F++L ELV VLP  L      L
Sbjct: 417  AMEQGETPLTMLQSQVPNIVKALHKQMKEKSVKTRQCCFNMLTELVNVLPGALTQHIPVL 476

Query: 1451 VPGIEKALNDKSSTSNLKIEALAFTRIVMASHSPSVFHPYIQALSGPILSAIGDRYYKVT 1630
            VPGI  +LND+SS+SNLKI+AL+   +++ +HSP VFHP++QAL  P+++ +GD +YK+T
Sbjct: 477  VPGIIFSLNDESSSSNLKIDALSCLYVILCNHSPQVFHPHVQALVPPVVACVGDPFYKIT 536

Query: 1631 AEALRVCGELVRVLRPNFQAHSIDFRPYISPIYKAILARLANQDQDQEVKECAISCMSLV 1810
            +EAL V  +LV+V+RP  Q  S D  PYI  ++   + RL   D DQ+VKE AISCM  +
Sbjct: 537  SEALLVTQQLVKVIRPLDQPSSFDATPYIKDVFTCTIKRLKAADIDQDVKERAISCMGQI 596

Query: 1811 IATFGDGLQRELPACLPILVDRMGNEITRLTAVKAFAVIANSPLRIDLSCVLDHVVSELT 1990
            I   GD L  +LP  L I ++R+ NEITRLT VKA  +IA SPL+IDL  VL   V  L 
Sbjct: 597  ICNLGDNLGSDLPNTLQIFLERLKNEITRLTTVKALTLIAGSPLKIDLRPVLGEGVPILA 656

Query: 1991 AFLRKANRALRQATLGTLNSLVVTYGSQIGSSSYETILTELSTLISDVDLHMAALALELC 2170
            +FLRK  RAL+  TL  L+ L+  Y   + ++  + +L EL  LIS+ D+H++ +A+   
Sbjct: 657  SFLRKNQRALKLGTLSALDILIKNYSDSLTAAMIDAVLDELPPLISESDMHVSQMAISFL 716

Query: 2171 CTI-MVDRRSVKNVGLAVIHKVLPEALTLIRSXXXXXXXXXXXXXXXXXXXXSA--NISF 2341
             T+  V   S+  +       +L E + L+RS                    +   N+ +
Sbjct: 717  TTLAKVYPSSLSKIS----GSILNELIGLVRSPLLQGGALSAMLDFFQALVVTGTNNLGY 772

Query: 2342 ETLLNSLISTAKPSQSGGLSKQALFSIAQCVAVLCLAAGDKKCASTIEMLKGILNDDSST 2521
              LL  L        +    KQ+ +SIA+CVA L  A   +  A   + ++ + N   ST
Sbjct: 773  MDLLRMLTGPVYSQSTALTHKQSYYSIAKCVAALTRACPKEGPAVVGQFIQDVKN-SRST 831

Query: 2522 NSAKQHMALLCLGEIGRRKDLSNHDQIENIVIESFQSPFEEIKSAASYALGNIAVGNLSK 2701
            +S +  +ALL LGE+G   DLS   +++++++E+F SP EE+KSAASYALG+I+VGNL +
Sbjct: 832  DSIRL-LALLSLGEVGHHIDLSGQLELKSVILEAFSSPSEEVKSAASYALGSISVGNLPE 890

Query: 2702 YLPFILDQIDNQQKKQYLLLHSLKEVIARQSVDHTGQSELQDSNILKILALLFNHCESEE 2881
            YLPF+L +I +Q K+QYLLLHSLKE+I+  SV   G     ++    I ALL  HCE  E
Sbjct: 891  YLPFVLQEITSQPKRQYLLLHSLKEIISSASV--VGLKPYVEN----IWALLLKHCECAE 944

Query: 2882 EGVRNVVAECLGKIALIEPNKLIPALKERTSSPAANTRATVAIAIKYSIVERTGKIDAIL 3061
            EG RNVVAECLGK+ LI+P  L+P LK    S ++  R++V  A+K++I +    ID +L
Sbjct: 945  EGTRNVVAECLGKLTLIDPETLLPRLKGYLISGSSYARSSVVTAVKFTISDHPQPIDPLL 1004

Query: 3062 YSEISTFLMLIKDSDRHVRRAAVLALSTAAHNKPNLIKRXXXXXXXXXYDQTVVKQELIR 3241
             + I  FL  ++D D +VRR A++  ++AAHNKP+LI+          Y++T V++ELIR
Sbjct: 1005 KNCIGDFLKTLEDPDLNVRRVALVTFNSAAHNKPSLIRDLLDTVLPHLYNETKVRKELIR 1064

Query: 3242 TVDLGPFKHVVDDGLELRKAAFECVDTLLDSCLDQVNPSAFIVPFLLSGLGDHYDVKMPC 3421
             V++GPFKH VDDGL++RKAAFEC+ TLLDSCLD+++   F+   +  GL DHYD+KM  
Sbjct: 1065 EVEMGPFKHTVDDGLDIRKAAFECMYTLLDSCLDRLDIFEFL-NHVEDGLKDHYDIKMLT 1123

Query: 3422 HLILSKLADKCPSAVLAVLDSLVEPLEKTIVHKPKGDAVKQEIDRNEGXXXXXXXXXXXX 3601
             L+L +L+  CPSAVL  LD LVEPL  T   K K ++VKQE ++ +             
Sbjct: 1124 FLMLVRLSTLCPSAVLQRLDRLVEPLRATCTTKVKANSVKQEFEKQDELKRSAMRAVAAL 1183

Query: 3602 XXXXGSDYSMKLKKLMSKITSTSSLAEKYNSVRSE 3706
                 ++ S  + +  S+I+S   LA  + S++ +
Sbjct: 1184 LTIPEAEKSPLMSEFQSQISSNPELAAIFESIQKD 1218

>Q6ZQ73:CAND2_MOUSE Cullin-associated NEDD8-dissociated protein 2 - Mus musculus (Mouse)|
          Length = 1235

 Score =  768 bits (1984), Expect = 0.0
 Identities = 449/1182 (37%), Positives = 687/1182 (58%), Gaps = 16/1182 (1%)
 Frame = +2

Query: 65   ITGILEKMTGKDKDYRYMATSDLLSELNKESFKADQDLESKLTNIVLQQLEDASGDVSGL 244
            I+ +LEKMT  DKD+R+MATSDL+SEL K+S + D+D E K+   +L+ LED SG+V  L
Sbjct: 8    ISSLLEKMTSSDKDFRFMATSDLMSELQKDSIQLDEDSERKVVRTLLRLLEDRSGEVQNL 67

Query: 245  AVKCLAPLVKKVSEERVVEMTDKLCDKLLNGKDQHRDTASIALKAVIVEVTTASLSEKIL 424
            AVKCL PLV KV E +V  + D LC  + + K+Q RD A I LK V+ E+  A+    + 
Sbjct: 68   AVKCLGPLVGKVKEYQVENIVDTLCANMRSDKEQLRDIAGIGLKTVLSELPPAATGSGLA 127

Query: 425  VS----LAPQLIKGVTSGKSAEIKCECLDILGDVLHRFGNVITKDHAYMLTALLAQLSST 592
            ++    +  QL   +   +   ++ E LDIL D+L R G  +   HA +L  LL QLSS 
Sbjct: 128  INVCRKITGQLTSAIAQQEDVAVQLEALDILSDMLSRLGAPLGTFHASLLHCLLPQLSSP 187

Query: 593  QASVRKKSVSCIASLAPCLSDDLLAKGTLEVVKLLKNRKAKSD--ITRTNIQMIGALSRS 766
            + +VRK++V  +  LA   S DL  +    +V  L   +A +     RT IQ +G++ R 
Sbjct: 188  RLAVRKRTVVALGHLAAACSTDLFVELADHLVDRLPGPRAPASPAAIRTLIQCLGSVGRQ 247

Query: 767  VGYRFGPHLAEAVPLLINYCTSASENDEELREYSLQALESFMLRCPRDISPYCEGILNLA 946
             G+R G HL   VP++  +C     +D+ELRE  LQA E+F+ +CP+++ P+   + +L 
Sbjct: 248  AGHRLGAHLDRLVPMVEEFCNL---DDDELRESCLQAFEAFLRKCPKEMDPHVPNVTSLC 304

Query: 947  LEYVSYDPNFXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-ASWKVRRASAKCISAIIVS 1123
            L+Y+ +DPN+                                SWKVRRA+AKC++A+I S
Sbjct: 305  LQYMKHDPNYDHDSDDEEQMETEDSEFSEQESEDEYSDDDDMSWKVRRAAAKCMAALISS 364

Query: 1124 RPQMLSKMYQEACPKLVDRFREREENVKMDIFNTFIELLRQTGNVTKGQGDIDESSPRW- 1300
            RP +L   +    P L+ RF+EREENVK DIF  +I LLR T         ++E +    
Sbjct: 365  RPDLLPDFHCTLAPALIRRFKEREENVKADIFGAYIMLLRHTRPPKGWLEAVEEPTQTGR 424

Query: 1301 ---LLKQEVPKIVKSINRQLREKSIKTKVGAFSVLKELVVVLPDCLADQFGSLVPGIEKA 1471
               +L+ +VP ++K++ RQL++++++T+ G F++  EL  VLP  LA+    LV GI  +
Sbjct: 425  NLNMLRAQVPLVIKALQRQLKDRNVRTRQGCFNLFTELAGVLPGSLAEHMAVLVSGIVFS 484

Query: 1472 LNDKSSTSNLKIEALAFTRIVMASHSPSVFHPYIQALSGPILSAIGDRYYKVTAEALRVC 1651
            L D SS+S ++++ALAF + ++ +     FHP++  L  P+++ + D +YKV AEAL V 
Sbjct: 485  LADYSSSSTIRMDALAFLQGLLGTEPAEAFHPHLPTLLPPVMACVADPFYKVAAEALLVL 544

Query: 1652 GELVRVLRPNFQAHSIDFRPYISPIYKAILARLANQDQDQEVKECAISCMSLVIATFGDG 1831
             ELVR L P  +   +D  PY+  +  A LARL   D DQEVKE AISC+  ++   GD 
Sbjct: 545  QELVRTLWPLDRPRLLDPEPYVGEMSTATLARLRATDLDQEVKERAISCVGHLVGHLGDR 604

Query: 1832 LQRELPACLPILVDRMGNEITRLTAVKAFAVIANSPLRIDLSCVLDHVVSELTAFLRKAN 2011
            L  +L   L +L+DR+ NEITRL AVKA  ++A SPLR+DL  +L   +  L +FLRK  
Sbjct: 605  LGDDLEPTLMLLLDRLRNEITRLPAVKALTLVAMSPLRLDLQPILAEALPILASFLRKNQ 664

Query: 2012 RALRQATLGTLNSLVVTYGSQIGSSSYETILTELSTLISDVDLHMAALALELCCTIMVDR 2191
            RALR ATL  L++L  + G  +   +  T+LTEL  L+S+ D+H+A LA++   T+   +
Sbjct: 665  RALRLATLAALDALAQSQGLGLPPPAVRTVLTELPALVSENDMHVAQLAVDFLTTVTQTQ 724

Query: 2192 RSVKNVGLAVIHKVLPEALTLIRSXXXXXXXXXXXXXXXXXXXXSANISFE-TLLNSLIS 2368
             S     + V   VL E L L+ S                    +     E + L SL++
Sbjct: 725  PSSL---VEVSGPVLGELLQLLHSPLLPAGVLAATEGFLQALVGTRPPCVEYSELISLLT 781

Query: 2369 TAKPSQSG----GLSKQALFSIAQCVAVLCLAAGDKKCASTIEMLKGILNDDSSTNSAKQ 2536
                +Q G    GL KQ   S+A+CVA L  A   +   +   ++    +  SST    +
Sbjct: 782  APVYNQVGDGGPGLHKQVFHSLARCVAALSAACPQEAAGTASRLVCDAKSPHSST--GVK 839

Query: 2537 HMALLCLGEIGRRKDLSNHDQIENIVIESFQSPFEEIKSAASYALGNIAVGNLSKYLPFI 2716
             +A L L E+G+        +++ +++E+  SP E++++AA+YALG +  GNL  +LPF+
Sbjct: 840  VLAFLSLAEVGQVAGPGPQRELKTVLLEALGSPSEDVRAAAAYALGRVGAGNLPDFLPFL 899

Query: 2717 LDQIDNQQKKQYLLLHSLKEVIARQSVDHTGQSELQDSNILKILALLFNHCESEEEGVRN 2896
            L QI+ Q ++QYLLLH+L+E +     D+  +  ++D     + ALLF  CES EEG R 
Sbjct: 900  LAQIEAQPRRQYLLLHALREALGAAQPDNL-KPYVED-----VWALLFQRCESPEEGTRC 953

Query: 2897 VVAECLGKIALIEPNKLIPALKERTSSPAANTRATVAIAIKYSIVERTGKIDAILYSEIS 3076
            VVAEC+GK+  + P  L+P  +++ ++    TR+TV  A+K+ I ++   ID +L S I+
Sbjct: 954  VVAECIGKLVFVNPPYLLPRFRKQLAAGQPYTRSTVITAVKFLISDQPHSIDPLLKSFIA 1013

Query: 3077 TFLMLIKDSDRHVRRAAVLALSTAAHNKPNLIKRXXXXXXXXXYDQTVVKQELIRTVDLG 3256
             F+  ++D D +VRRA +   ++A HNKP+L++          Y +T ++++LIR V++G
Sbjct: 1014 EFMESLQDPDLNVRRATLTFFNSAVHNKPSLVRDLLDDILPLLYQETKIRRDLIREVEMG 1073

Query: 3257 PFKHVVDDGLELRKAAFECVDTLLDSCLDQVNPSAFIVPFLLSGLGDHYDVKMPCHLILS 3436
            PFKH VDDGL++RKAAFEC+ +LL+SCL Q++   F+   +  GL DHYD++M   ++L+
Sbjct: 1074 PFKHTVDDGLDVRKAAFECMYSLLESCLGQLDMCEFL-NHVEDGLKDHYDIRMLTFIMLA 1132

Query: 3437 KLADKCPSAVLAVLDSLVEPLEKTIVHKPKGDAVKQEIDRNE 3562
            +LA  CP+ VL  +D L+EPL  T   K K  +VKQE+++ E
Sbjct: 1133 RLATLCPAPVLQRVDRLIEPLRATCTAKVKAGSVKQELEKQE 1174

>Q9R0L4:CAND2_RAT Cullin-associated NEDD8-dissociated protein 2 - Rattus norvegicus|
            (Rat)
          Length = 1273

 Score =  742 bits (1916), Expect = 0.0
 Identities = 446/1220 (36%), Positives = 686/1220 (56%), Gaps = 54/1220 (4%)
 Frame = +2

Query: 65   ITGILEKMTGKDKDY--------------------------------------RYMATSD 130
            I+ +LEKMT  DKD+                                      R+MATSD
Sbjct: 8    ISSLLEKMTSSDKDFSPKSLGGSRVLDPLPWLQILAAITDWISGDRTQDLALPRFMATSD 67

Query: 131  LLSELNKESFKADQDLESKLTNIVLQQLEDASGDVSGLAVKCLAPLVKKVSEERVVEMTD 310
            L+SEL K+S + D+D E K+   +L+ LED SG+V  LAVKCL PLV KV E +V  + D
Sbjct: 68   LMSELQKDSIQLDEDSERKVVRTLLRLLEDRSGEVQNLAVKCLGPLVGKVKEYQVENIVD 127

Query: 311  KLCDKLLNGKDQHRDTASIALKAVIVEVTTASLSEKILVS----LAPQLIKGVTSGKSAE 478
             LC  + + K+Q RD A I LK V+ E+  A+    + +S    +  QL   +   +   
Sbjct: 128  TLCANMRSDKEQLRDIAGIGLKTVLSELPPAATGSGLAISVCRKITGQLTSAIAQQEDVA 187

Query: 479  IKCECLDILGDVLHRFGNVITKDHAYMLTALLAQLSSTQASVRKKSVSCIASLAPCLSDD 658
            ++ E LDIL D+L R G  +   HA +L  LL QLSS + +VRK++V  +  LA   S D
Sbjct: 188  VQLEALDILSDMLSRLGAPLGTFHASLLHCLLPQLSSPRLAVRKRTVVALGHLAAACSTD 247

Query: 659  LLAKGTLEVVKLLKNRKAKSD--ITRTNIQMIGALSRSVGYRFGPHLAEAVPLLINYCTS 832
            L  +    +V  L   +A +     RT IQ +G++ R  G+R G HL   +PL+  +C  
Sbjct: 248  LFVELADHLVDRLPGPRAPASPAAIRTLIQCLGSVGRQAGHRLGAHLDRLMPLVEEFCNL 307

Query: 833  ASENDEELREYSLQALESFMLRCPRDISPYCEGILNLALEYVSYDPNFXXXXXXXXXXXX 1012
               +D+ELRE  LQA E+F+ +CP+++ P+   + +L L+Y+ +DPN+            
Sbjct: 308  ---DDDELRESCLQAFEAFLRKCPKEMDPHVPNVTSLCLQYMKHDPNYNHDSDEEEQMET 364

Query: 1013 XXXXXXXXXXXXXXXXXX-ASWKVRRASAKCISAIIVSRPQMLSKMYQEACPKLVDRFRE 1189
                                SWKVRRA+AKC++A+I SRP +L   +    P L+  F+E
Sbjct: 365  EDSEFSEQESEDEYSDDDDMSWKVRRAAAKCMAALISSRPDLLPDFHCTLAPALIRCFKE 424

Query: 1190 REENVKMDIFNTFIELLRQTGNVTKGQGDIDESSPRW----LLKQEVPKIVKSINRQLRE 1357
            REENVK DIF  +I LLR T         ++E +       +L+ +VP ++K++ RQL++
Sbjct: 425  REENVKADIFGAYIMLLRHTRPPKGWLEAVEEPTQTGRNLNMLRAQVPLVMKALQRQLKD 484

Query: 1358 KSIKTKVGAFSVLKELVVVLPDCLADQFGSLVPGIEKALNDKSSTSNLKIEALAFTRIVM 1537
            ++++T+ G F++  EL  VLP CLA+    LV GI  +L D SS+S ++++ALAF + ++
Sbjct: 485  RNVRTRQGCFNLFTELAGVLPGCLAEHMTVLVSGIVFSLADYSSSSTIRMDALAFLQGLL 544

Query: 1538 ASHSPSVFHPYIQALSGPILSAIGDRYYKVTAEALRVCGELVRVLRPNFQAHSIDFRPYI 1717
             +     FHP++  L  P+++ + D +YKV AEAL V  ELVR L P  +   +D  PY+
Sbjct: 545  GTEPAEAFHPHLPTLLPPVMACVADPFYKVAAEALLVLQELVRTLWPLDRPRLLDPEPYV 604

Query: 1718 SPIYKAILARLANQDQDQEVKECAISCMSLVIATFGDGLQRELPACLPILVDRMGNEITR 1897
              +  A LARL   D DQEVKE AISC+  ++   GD L  +L   L +L+DR+ NEITR
Sbjct: 605  GEMSTATLARLRATDLDQEVKERAISCVGHLVGHLGDRLGDDLEPTLLLLLDRLRNEITR 664

Query: 1898 LTAVKAFAVIANSPLRIDLSCVLDHVVSELTAFLRKANRALRQATLGTLNSLVVTYGSQI 2077
            L AVKA  ++A SPLR+DL  +L   +  L +FLRK  RALR ATL  L++L  + G  +
Sbjct: 665  LPAVKALTLVAVSPLRLDLQPILAEALPILASFLRKNQRALRLATLAALDALAQSQGLGL 724

Query: 2078 GSSSYETILTELSTLISDVDLHMAALALELCCTIMVDRRSVKNVGLAVIHKVLPEALTLI 2257
               +  ++L EL  L+S+ D+H+A LA++   T+   + +     + V   VL E L L+
Sbjct: 725  PPPAVRSVLAELPALVSENDMHVAQLAVDFLTTVTQTQPASL---VEVSGPVLEELLQLL 781

Query: 2258 RSXXXXXXXXXXXXXXXXXXXXSANISFE-TLLNSLISTAKPSQSG----GLSKQALFSI 2422
             S                    +     E + L SL++    +Q G    GL KQ   S+
Sbjct: 782  HSPLLPAGVLAATEGFLQALVGTRPPCVEYSELISLLTAPVYNQVGDGGPGLHKQVFHSL 841

Query: 2423 AQCVAVLCLAAGDKKCASTIEMLKGILNDDSSTNSAKQHMALLCLGEIGRRKDLSNHDQI 2602
            A+CVA L  A   +   +   ++    +  SST    + +A L L E+G+        ++
Sbjct: 842  ARCVAALSAACPQEAAGTASRLVCDARSPHSST--GVKVLAFLSLAEVGQVAGPGPQREL 899

Query: 2603 ENIVIESFQSPFEEIKSAASYALGNIAVGNLSKYLPFILDQIDNQQKKQYLLLHSLKEVI 2782
            + +++E+  SP E++++AA+YALG +  GNL  +LPF+L QI+ Q ++QYLLLH+L+E +
Sbjct: 900  KTVLLEALGSPSEDVRAAAAYALGRVGAGNLPDFLPFLLAQIEAQPRRQYLLLHALREAL 959

Query: 2783 ARQSVDHTGQSELQDSNILKILALLFNHCESEEEGVRNVVAECLGKIALIEPNKLIPALK 2962
                 D+  +  ++D     + ALLF  CES EEG R VVAEC+GK+  + P  L+P  +
Sbjct: 960  GAAQPDNL-KPYVED-----VWALLFQRCESPEEGTRCVVAECIGKLVFVNPPFLLPRFR 1013

Query: 2963 ERTSSPAANTRATVAIAIKYSIVERTGKIDAILYSEISTFLMLIKDSDRHVRRAAVLALS 3142
            ++ ++    TR+TV  A+K+ I ++   ID +L S I+ F+  ++D D +VRRA +   +
Sbjct: 1014 KQLAAGQPYTRSTVITAVKFLISDQPHSIDPLLKSFIAEFMESLQDPDLNVRRATLTFFN 1073

Query: 3143 TAAHNKPNLIKRXXXXXXXXXYDQTVVKQELIRTVDLGPFKHVVDDGLELRKAAFECVDT 3322
            +A HNKP+L++          Y +T ++++LIR V++GPFKH VDDGL++RKAAFEC+ +
Sbjct: 1074 SAVHNKPSLVRDLLDDILPLLYQETKIRRDLIREVEMGPFKHTVDDGLDVRKAAFECMYS 1133

Query: 3323 LLDSCLDQVNPSAFIVPFLLSGLGDHYDVKMPCHLILSKLADKCPSAVLAVLDSLVEPLE 3502
            LL+SCL Q++   F+   +  GL DHYD++M   ++L++LA  CP+ VL  +D L+EPL 
Sbjct: 1134 LLESCLGQLDICEFL-NHVEDGLKDHYDIRMLTFIMLARLAALCPAPVLQRVDRLIEPLR 1192

Query: 3503 KTIVHKPKGDAVKQEIDRNE 3562
             T   K K  +VKQE+++ +
Sbjct: 1193 ATCTAKVKAGSVKQELEKQD 1212

>O75155:CAND2_HUMAN Cullin-associated NEDD8-dissociated protein 2 - Homo sapiens (Human)|
          Length = 1119

 Score =  620 bits (1600), Expect = e-176
 Identities = 389/1112 (34%), Positives = 606/1112 (54%), Gaps = 13/1112 (1%)
 Frame = +2

Query: 410  SEKILVSLAPQLIKGVTSGKSAEIKCECLDILGDVLHRFGNVITKDHAYMLTALLAQLSS 589
            SE+ +V +  +L++     K+ E++   +  LG  L  F       HA +L  LL QLSS
Sbjct: 45   SERKVVKMLLRLLED----KNGEVQNLAVKWLGVPLGAF-------HASLLHCLLPQLSS 93

Query: 590  TQASVRKKSVSCIASLAPCLSDDLLAKGTLEVVKLLKNRKAKSDIT--RTNIQMIGALSR 763
             + +VRK++V  +  LA   S DL  +    ++  L   +  +  T  RT IQ +G++ R
Sbjct: 94   PRLAVRKRAVGALGHLATACSTDLFVELADHLLDRLPGPRVPTSPTAIRTLIQCLGSVGR 153

Query: 764  SVGYRFGPHLAEAVPLLINYCTSASENDEELREYSLQALESFMLRCPRDISPYCEGILNL 943
              G+R G HL   VPL+ ++C     +D+ELRE  LQA E+F+ +CP+++ P+   + +L
Sbjct: 154  QAGHRLGAHLDRLVPLVEDFCNL---DDDELRESCLQAFEAFLRKCPKEMGPHVPNVTSL 210

Query: 944  ALEYVSYDPNFXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--ASWKVRRASAKCISAII 1117
             L+Y+ +DPN+                                 SWKVRRA+AKCI+A+I
Sbjct: 211  CLQYIKHDPNYNYDSDEDEEQMETEDSEFSEQESEDEYSDDDDMSWKVRRAAAKCIAALI 270

Query: 1118 VSRPQMLSKMYQEACPKLVDRFREREENVKMDIFNTFIELLRQT----GNVTKGQGDIDE 1285
             SRP +L   +    P L+ RF+EREENVK D+F  +I LLRQT    G +   +     
Sbjct: 271  SSRPDLLPDFHCTLAPVLIRRFKEREENVKADVFTAYIVLLRQTRPPKGWLEAMEEPTQT 330

Query: 1286 SSPRWLLKQEVPKIVKSINRQLREKSIKTKVGAFSVLKELVVVLPDCLADQFGSLVPGIE 1465
             S   +L+ +VP +VK++ RQL+++S++ + G FS+L EL  VLP  LA+    LV GI 
Sbjct: 331  GSNLHMLRGQVPLVVKALQRQLKDRSVRARQGCFSLLTELAGVLPGSLAEHMPVLVSGII 390

Query: 1466 KALNDKSSTSNLKIEALAFTRIVMASHSPSVFHPYIQALSGPILSAIGDRYYKVTAEALR 1645
             +L D+SS+S ++++ALAF + ++ +     FHP++  L  P+++ + D +YK+ AEAL 
Sbjct: 391  FSLADRSSSSTIRMDALAFLQGLLGTEPAEAFHPHLPILLPPVMACVADSFYKIAAEALV 450

Query: 1646 VCGELVRVLRPNFQAHSIDFRPYISPIYKAILARLANQDQDQEVKECAISCMSLVIATFG 1825
            V  ELVR L P  +   +D  PY+  +    LARL   D DQEVKE AISCM  ++   G
Sbjct: 451  VLQELVRALWPLHRPRMLDPEPYVGEMSAVTLARLRATDLDQEVKERAISCMGHLVGHLG 510

Query: 1826 DGLQRELPACLPILVDRMGNEITRLTAVKAFAVIANSPLRIDLSCVLDHVVSELTAFLRK 2005
            D L  +L   L +L+DR+ NEITRL A+KA  ++A SPL++DL  +L   +  L +FLRK
Sbjct: 511  DRLGDDLEPTLLLLLDRLRNEITRLPAIKALTLVAVSPLQLDLQPILAEALHILASFLRK 570

Query: 2006 ANRALRQATLGTLNSLVVTYGSQIGSSSYETILTELSTLISDVDLHMAALALELCCTIMV 2185
              RALR ATL  L++L  + G  +  S+ + +L EL  L+++ D+H+A LA++   T+  
Sbjct: 571  NQRALRLATLAALDALAQSQGLSLPPSAVQAVLAELPALVNESDMHVAQLAVDFLATVTQ 630

Query: 2186 DRRSVKNVGLAVIHKVLPEALTLIRSXXXXXXXXXXXXXXXXXXXXSANISFE-----TL 2350
             + +     + V   VL E L L+RS                    +     +     +L
Sbjct: 631  AQPASL---VEVSGPVLSELLRLLRSPLLPAGVLAAAEGFLQALVGTRPPCVDYAKLISL 687

Query: 2351 LNSLISTAKPSQSGGLSKQALFSIAQCVAVLCLAAGDKKCASTIEMLKGILNDDSSTNSA 2530
            L + +         GL KQ   S+A+CVA L  AA  ++ AST   L        S+   
Sbjct: 688  LTAPVYEQAVDGGPGLHKQVFHSLARCVAALS-AACPQEAASTASRLVCDARSPHSSTGV 746

Query: 2531 KQHMALLCLGEIGRRKDLSNHDQIENIVIESFQSPFEEIKSAASYALGNIAVGNLSKYLP 2710
            K  +A L L E+G+        +++ +++E+  SP E++++AASYALG +  G+L  +LP
Sbjct: 747  KV-LAFLSLAEVGQVAGPGPQRELKAVLLEALGSPSEDVRAAASYALGRVGAGSLPDFLP 805

Query: 2711 FILDQIDNQQKKQYLLLHSLKEVIARQSVDHTGQSELQDSNILKILALLFNHCESEEEGV 2890
            F+L+QI+ + ++QYLLLHSL+E +     D   +   +D     I ALLF  CE  EEG 
Sbjct: 806  FLLEQIEAEPRRQYLLLHSLREALGAAQPDSL-KPYAED-----IWALLFQRCEGAEEGT 859

Query: 2891 RNVVAECLGKIALIEPNKLIPALKERTSSPAANTRATVAIAIKYSIVERTGKIDAILYSE 3070
            R VVAEC+GK+ L+ P+ L+P L+++ ++   +TR+TV  A+K+ I ++   ID +L S 
Sbjct: 860  RGVVAECIGKLVLVNPSFLLPRLRKQLAAGRPHTRSTVITAVKFLISDQPHPIDPLLKSF 919

Query: 3071 ISTFLMLIKDSDRHVRRAAVLALSTAAHNKPNLIKRXXXXXXXXXYDQTVVKQELIRTVD 3250
            I                        A HNKP+L++          Y +T ++++LIR V+
Sbjct: 920  I------------------------AVHNKPSLVRDLLDDILPLLYQETKIRRDLIREVE 955

Query: 3251 LGPFKHVVDDGLELRKAAFECVDTLLDSCLDQVNPSAFIVPFLLSGLGDHYDVKMPCHLI 3430
            +GPFKH VDDGL++RKAAFEC+ +LL+SCL Q++   F+   +  GL DHYD++M   ++
Sbjct: 956  MGPFKHTVDDGLDVRKAAFECMYSLLESCLGQLDICEFL-NHVEDGLKDHYDIRMLTFIM 1014

Query: 3431 LSKLADKCPSAVLAVLDSLVEPLEKTIVHKPKGDAVKQEIDRNEGXXXXXXXXXXXXXXX 3610
            +++LA  CP+ VL  +D L+EPL  T   K K  +VKQE ++ +                
Sbjct: 1015 VARLATLCPAPVLQRVDRLIEPLRATCTAKVKAGSVKQEFEKQDELKRSAMRAVAALLTI 1074

Query: 3611 XGSDYSMKLKKLMSKITSTSSLAEKYNSVRSE 3706
                 S  +    S+I S   LA  + S++ +
Sbjct: 1075 PEVGKSPIMADFSSQIRSNPELAALFESIQKD 1106



 Score = 77.0 bits (188), Expect = 6e-13
 Identities = 37/72 (51%), Positives = 54/72 (75%)
 Frame = +2

Query: 44  VAMANTNITGILEKMTGKDKDYRYMATSDLLSELNKESFKADQDLESKLTNIVLQQLEDA 223
           ++ A  +I+ +LEKMT  DKD+R+MATSDL+SEL K+S + D+D E K+  ++L+ LED 
Sbjct: 1   MSTAAFHISSLLEKMTSSDKDFRFMATSDLMSELQKDSIQLDEDSERKVVKMLLRLLEDK 60

Query: 224 SGDVSGLAVKCL 259
           +G+V  LAVK L
Sbjct: 61  NGEVQNLAVKWL 72

>P54613:2AAB_PIG Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A|
            beta isoform - Sus scrofa (Pig)
          Length = 602

 Score = 42.0 bits (97), Expect = 0.020
 Identities = 52/224 (23%), Positives = 86/224 (38%), Gaps = 3/224 (1%)
 Frame = +2

Query: 2825 DSNILKILALLFNHCESEEEGVRNVVAECLGKIALIEPNKLIPALKERTSSPAANT---R 2995
            DS   +I+ L  N    E++ VR +  E    IA +     + AL   T   AA     R
Sbjct: 212  DSVKSEIVPLFTNLASDEQDSVRLLAVEACVSIAQLLSQDDLEALVMPTLRQAAEDKSWR 271

Query: 2996 ATVAIAIKYSIVERTGKIDAILYSEISTFLMLIKDSDRHVRRAAVLALSTAAHNKPNLIK 3175
                +A K+S ++R       L   I  F  L+KD +  VR AA   +     N P    
Sbjct: 272  VRYMVADKFSELQRAVGPKITLNDLIPAFQNLLKDCEAEVRAAAAHKVKELCENLP---- 327

Query: 3176 RXXXXXXXXXYDQTVVKQELIRTVDLGPFKHVVDDGLELRKAAFECVDTLLDSCLDQVNP 3355
                        +T++  +++  +     K +V D  +  K+A   V   L + L + N 
Sbjct: 328  --------IEGRETIIMNQILPCI-----KELVSDTNQHVKSALASVIMGLSTILGKENT 374

Query: 3356 SAFIVPFLLSGLGDHYDVKMPCHLILSKLADKCPSAVLAVLDSL 3487
               ++P                 L L++L D+CP   L ++ +L
Sbjct: 375  IEHLLP-----------------LFLAQLKDECPEVRLNIISNL 401

>Q95Q95:TOR_CAEEL Target of rapamycin homolog - Caenorhabditis elegans|
          Length = 2697

 Score = 39.7 bits (91), Expect = 0.10
 Identities = 38/173 (21%), Positives = 70/173 (40%), Gaps = 5/173 (2%)
 Frame = +2

Query: 440  QLIKGVTSGKSAEIKCECLDILGDV---LHRFGNVITKDHAYMLTALLAQLSSTQASVRK 610
            +++K V S        + L ILG +    H+      +    + TAL   +S T +   +
Sbjct: 870  RILKTVMSNTMRREAIKTLGILGAIDPYTHKVFTGSVQSSTAISTALSLPISETDSKDPR 929

Query: 611  KSVSCIASLAPCLSDDLLAKGTLEVVKLLKNRKAKSDITRTNIQMIGALSRSVGYRFGPH 790
            + +    +   C  ++     T+  + L+   +          Q I  + RS+G     +
Sbjct: 930  QDIIHWFNYEKCTLEEFYPAITIANLMLMMQDEDSQSYAEI-AQAIVTIFRSLGDMAPLY 988

Query: 791  LAEAVPLLINYCTSASE--NDEELREYSLQALESFMLRCPRDISPYCEGILNL 943
              + +P LI  C  A+E  N   LRE+ LQ L +F+    +  +PY   I  +
Sbjct: 989  TEQVIPRLIEVCRRATESSNRANLREFFLQQLANFVAIIRKHAAPYMPAIFTI 1041

>P33892:GCN1_YEAST Translational activator GCN1 - Saccharomyces cerevisiae (Baker's|
            yeast)
          Length = 2672

 Score = 39.7 bits (91), Expect = 0.10
 Identities = 70/345 (20%), Positives = 137/345 (39%), Gaps = 36/345 (10%)
 Frame = +2

Query: 1316 VPKIVKSINRQLREKSIKTKVGAFSVLKELVVVLPDCLADQFGSLVPGIEKALND----- 1480
            V K++      L E + +TK G+  +L  +  + P  L+    ++VP I   LND     
Sbjct: 1445 VKKLIPVAVSNLDEIAWRTKRGSVQLLGNMAYLDPTQLSASLSTIVPEIVGVLNDSHKEV 1504

Query: 1481 -KSSTSNLK------------------IEALAF-TRIVMASHSPSVFHPYIQALSGPILS 1600
             K++  +LK                  ++A+   T+    +    +   ++  + GP L+
Sbjct: 1505 RKAADESLKRFGEVIRNPEIQKLVPVLLQAIGDPTKYTEEALDSLIQTQFVHYIDGPSLA 1564

Query: 1601 AI--------GDRYYKVTAEALRVCGELVRVLRPNFQAHSIDFRPYISPIYKAILARLAN 1756
             I         DR   +  +A ++ G +  ++       + D  PY+  +   +   +A 
Sbjct: 1565 LIIHIIHRGMHDRSANIKRKACKIVGNMAILV------DTKDLIPYLQQLIDEV--EIAM 1616

Query: 1757 QDQDQEVKECAISCMSLVIATFGDGLQRELPACLPILVDRMGNEI---TRLTAVKAFAVI 1927
             D     +  A   +  ++   G   + + P  +P L+D + +E     RL + +A A +
Sbjct: 1617 VDPVPNTRATAARALGALVERLG---EEQFPDLIPRLLDTLSDESKSGDRLGSAQALAEV 1673

Query: 1928 ANSPLRIDLSCVLDHVVSELTAFLRKANRALRQATLGTLNSLVVTYGSQIGSSSYETILT 2107
             +      L  +L  +++ +T F       +R+  +  L  L V +GSQ      + I  
Sbjct: 1674 ISGLGLTKLDEMLPTILAGVTNF----RAYIREGFMPLLLFLPVCFGSQFAPYINQIIQP 1729

Query: 2108 ELSTLISDVDLHMAALALELCCTIMVDRRSVKNVGLAVIHKVLPE 2242
             LS L +D D ++   AL+        +  VKN     +  +LPE
Sbjct: 1730 ILSGL-ADNDENIRDTALK------AGKLIVKNYATKAVDLLLPE 1767

>P35169:TOR1_YEAST Serine/threonine-protein kinase TOR1 - Saccharomyces cerevisiae|
            (Baker's yeast)
          Length = 2470

 Score = 39.3 bits (90), Expect = 0.13
 Identities = 43/155 (27%), Positives = 65/155 (41%), Gaps = 8/155 (5%)
 Frame = +2

Query: 1448 LVPGIEKALND-----KSSTSNLKIEALAFTRIVMASHSPSVFHPYIQALSGPILSAIGD 1612
            ++P I K L +     K STS+ + E  A     +   S  V  PYI+ L   +L    D
Sbjct: 703  VIPSIRKILLELLTKLKFSTSSREKEETASLLCTLIRSSKDVAKPYIEPLLNVLLPKFQD 762

Query: 1613 RYYKVTAEALRVCGELVRVLRPNFQAHSIDFRPYISPIYKAILARLANQDQDQEVK-ECA 1789
                V + ALR  GEL  V          D + Y+  ++  I+     QDQ    K E A
Sbjct: 763  TSSTVASTALRTIGELSVV-------GGEDMKIYLKDLFPLIIKTF--QDQSNSFKREAA 813

Query: 1790 ISCMSLVIATFGDGLQ--RELPACLPILVDRMGNE 1888
            +  +  + A+ G  +    + P  L ILV+ +  E
Sbjct: 814  LKALGQLAASSGYVIDPLLDYPELLGILVNILKTE 848

>O60100:IMB4_SCHPO Probable importin beta-4 subunit - Schizosaccharomyces pombe (Fission|
            yeast)
          Length = 1067

 Score = 39.3 bits (90), Expect = 0.13
 Identities = 70/327 (21%), Positives = 139/327 (42%), Gaps = 20/327 (6%)
 Frame = +2

Query: 47   AMANTNITGILEKMTG------KDKDYRYMATSDLLSELNKESFKADQDLESKLTNIVLQ 208
            A+ +  +  I+E +TG       D + R MA S ++S +  +S K       K   + L 
Sbjct: 244  AIISKALGNIIEIITGIANSKQVDDEIRCMALSFIISCIRFKSRKLQALKLGKPLVLTLM 303

Query: 209  QL--EDASGDV-----SGLAVKCLAPLVKKVSEERVV-EMTDKLCDKLLNGKDQHRDTAS 364
            ++  E+ + D+     + LA++ +  L   +S  +V   M +  C    + +  +R  A 
Sbjct: 304  EVATEETTDDIDEDCPARLALRSIDLLSTHLSPSQVFYPMFEAACAFSQSPQASYRKAAL 363

Query: 365  IALKAVIVEVTTASLSEKILVSLAPQLIKGVTSGKSAEIKCECLDILGDVLHRFGNVITK 544
            +++  V VE ++ S++   L ++ P +I G+      +++   L  L  +       ++K
Sbjct: 364  LSI-GVAVEGSSESVAGN-LPNIFPIIINGLCDN-DMDVRQAALLALSQIAVEIPTEVSK 420

Query: 545  DHAYMLTALLAQLSSTQASVRKKSVSCIASLAPCLSDDLLA---KGTLEVVKLLKNRKAK 715
             HA +L  +   +S+    V K + +CI +L   L    ++      +E +  L      
Sbjct: 421  HHAQLLPLVFELMSTQGVKVGKSACNCIDALLEGLDKSEISGYLPMLMERLVGLLEFSDT 480

Query: 716  SDITRTNIQMIGALSRSVGYRFGPHLAEAVPLLINYCTSASENDE--ELREYSLQALESF 889
             DI       IG+ + +    F P+  E     ++ C   +++DE  ELR   +  L + 
Sbjct: 481  PDIKSCVAAAIGSAAFAAQDDFIPYF-ERTMASLSQCLHTTDDDEGYELRGTVMDTLGAI 539

Query: 890  MLRCPRD-ISPYCEGILNLALEYVSYD 967
                 +    PY E ++ LA E +  D
Sbjct: 540  ANAVGKQAFLPYTEQLIQLAYEGIQID 566



 Score = 38.5 bits (88), Expect = 0.23
 Identities = 67/304 (22%), Positives = 127/304 (41%), Gaps = 19/304 (6%)
 Frame = +2

Query: 2657 ASYALGNIAVGNLSKYLPFILDQIDNQQKKQYLLLHSLKEVIARQSVDHTGQSELQDSNI 2836
            AS A+ + A+GN+ + +  I +      + + + L  +   I  +S       +LQ   +
Sbjct: 241  ASGAIISKALGNIIEIITGIANSKQVDDEIRCMALSFIISCIRFKS------RKLQALKL 294

Query: 2837 LKILALLFNHCESEEEGVRNVVAECLGKIAL---------IEPNKLIPALKER----TSS 2977
             K L L      +EE    ++  +C  ++AL         + P+++   + E     + S
Sbjct: 295  GKPLVLTLMEVATEET-TDDIDEDCPARLALRSIDLLSTHLSPSQVFYPMFEAACAFSQS 353

Query: 2978 PAANTRATVAIAIKYSIVERTGKIDAILYSEISTFLMLIKDSDRHVRRAAVLALSTAAHN 3157
            P A+ R    ++I  ++   +  +   L +     +  + D+D  VR+AA+LALS  A  
Sbjct: 354  PQASYRKAALLSIGVAVEGSSESVAGNLPNIFPIIINGLCDNDMDVRQAALLALSQIAVE 413

Query: 3158 KPNLIKRXXXXXXXXXYDQTVVKQELIRTVDLGPFKHVVDDGLELRKAAFECVDTLLDSC 3337
             P  + +                 +L+  V    F+ +   G+++ K+A  C+D LL+  
Sbjct: 414  IPTEVSKH--------------HAQLLPLV----FELMSTQGVKVGKSACNCIDALLEG- 454

Query: 3338 LDQVNPSAFIVPFLLSGL------GDHYDVKMPCHLILSKLADKCPSAVLAVLDSLVEPL 3499
            LD+   S ++ P L+  L       D  D+K       S +A    SA  A  D  +   
Sbjct: 455  LDKSEISGYL-PMLMERLVGLLEFSDTPDIK-------SCVAAAIGSAAFAAQDDFIPYF 506

Query: 3500 EKTI 3511
            E+T+
Sbjct: 507  ERTM 510

>Q80TV8:CLAP1_MOUSE CLIP-associating protein 1 - Mus musculus (Mouse)|
          Length = 1535

 Score = 37.0 bits (84), Expect = 0.66
 Identities = 49/236 (20%), Positives = 102/236 (43%), Gaps = 12/236 (5%)
 Frame = +2

Query: 65   ITGILEKMTGKDK--DYRYMATSDLLSELNKESFKADQDLESKLTNIVLQQLEDASGDVS 238
            +  +L++++  ++  + R  A  +LL    ++S    ++    +  ++L+ L D    + 
Sbjct: 1301 VADLLKELSNHNERVEERKGALLELLKITREDSLGVWEEHFKTILLLLLETLGDKDHSIR 1360

Query: 239  GLAVKCLAPLVKKVSE--ERVVEMTDKLCDKLLNGKDQHRDTASIALKAVIVEVTTASLS 412
             LA++ L  +++      +   E+T  +   L   KD H++    A      E   ++L+
Sbjct: 1361 ALALRVLREILRNQPARFKNYAELT--IMKTLEAHKDSHKEVVRAA------EEAASTLA 1412

Query: 413  EKILVSLAPQLIKGVTSGKSAEIKCECLDILGDVLHRFGNVITKDHAYMLTA-----LLA 577
              I      +++  +       I    + +   V+ R    ITK+    L       LL 
Sbjct: 1413 SSIHPEQCIKVLCPIIQTADYPINLAAIKMQTKVVER----ITKESLLQLLVDIIPGLLQ 1468

Query: 578  QLSSTQASVRKKSVSCIASLAPCLSDDL---LAKGTLEVVKLLKNRKAKSDITRTN 736
               +T++SVRK SV C+ ++   + +DL   LA+ T   +KLL     ++  T +N
Sbjct: 1469 GYDNTESSVRKASVFCLVAIYSVIGEDLKPHLAQLTGSKMKLLNLYIKRAQTTNSN 1524

>Q6PEE2:K0427_MOUSE Uncharacterized protein KIAA0427 homolog - Mus musculus (Mouse)|
          Length = 623

 Score = 36.6 bits (83), Expect = 0.86
 Identities = 31/107 (28%), Positives = 53/107 (49%), Gaps = 10/107 (9%)
 Frame = +2

Query: 1703 FRPYISPIYKAILARLANQDQDQEVKECAISCMSLVIATFGDGLQRELPACLPILV---- 1870
            FR  + PIY  +   L    Q Q+VKE A+ C S+ + + G  L+ +LP  +  L+    
Sbjct: 521  FRVLVCPIYTCLRELL----QSQDVKEDAVLCCSMELQSTGRLLEEQLPEMMTELLASAR 576

Query: 1871 DRM----GNEITRLTAVKAFAVIANS--PLRIDLSCVLDHVVSELTA 1993
            D+M     + +TR   ++   + ANS  PL   ++   +  + +LTA
Sbjct: 577  DKMLCPSESMLTRSLLLEVIELHANSWNPLTPPITQYYNRTIQKLTA 623

>O43310:K0427_HUMAN Uncharacterized protein KIAA0427 - Homo sapiens (Human)|
          Length = 598

 Score = 36.6 bits (83), Expect = 0.86
 Identities = 31/107 (28%), Positives = 53/107 (49%), Gaps = 10/107 (9%)
 Frame = +2

Query: 1703 FRPYISPIYKAILARLANQDQDQEVKECAISCMSLVIATFGDGLQRELPACLPILV---- 1870
            FR  + PIY  +   L    Q Q+VKE A+ C S+ + + G  L+ +LP  +  L+    
Sbjct: 496  FRVLVCPIYTCLRELL----QSQDVKEDAVLCCSMELQSTGRLLEEQLPEMMTELLASAR 551

Query: 1871 DRM----GNEITRLTAVKAFAVIANS--PLRIDLSCVLDHVVSELTA 1993
            D+M     + +TR   ++   + ANS  PL   ++   +  + +LTA
Sbjct: 552  DKMLCPSESMLTRSLLLEVIELHANSWNPLTPPITQYYNRTIQKLTA 598

>Q99JD4:CLAP2_RAT CLIP-associating protein 2 - Rattus norvegicus (Rat)|
          Length = 1286

 Score = 36.6 bits (83), Expect = 0.86
 Identities = 47/200 (23%), Positives = 89/200 (44%), Gaps = 4/200 (2%)
 Frame = +2

Query: 110  RYMATSDLLSELNKESFKADQDLESKLTNIVLQQLEDASGDVSGLAVKCLAPLVKKVSEE 289
            R +A  +L+    +ESF    +    +  ++L+ L D    +  LA+K L  +++     
Sbjct: 1069 RKIALYELMKLTQEESFSVWDEHFKTILLLLLETLGDKEPTIRALALKVLKEILRH-QPA 1127

Query: 290  RVVEMTDKLCDKLLNG-KDQHRDTASIALKAVIVEVTTASLSEKILVSLAPQLIKGVTSG 466
            R     +    K L   KD H++    A +A  V  T+ S  + I V L P +       
Sbjct: 1128 RFKNYAELTVMKTLEAHKDPHKEVVRSAEEAASVLATSISPEQCIKV-LCPIIQTADYPI 1186

Query: 467  KSAEIKCECLDILGDVLHRFGNVITKDHAYMLTALLAQLSSTQASVRKKSVSCIASLAPC 646
              A IK +   ++  V     N++  +   ++  L+    ++++SVRK  V C+ ++   
Sbjct: 1187 NLAAIKMQT-KVIERVSKETLNLLLPE---IMPGLIQGYDNSESSVRKACVFCLVAVHAV 1242

Query: 647  LSDDL---LAKGTLEVVKLL 697
            + D+L   L++ T   +KLL
Sbjct: 1243 IGDELKPHLSQLTGSKMKLL 1262

>Q8BRT1:CLAP2_MOUSE CLIP-associating protein 2 - Mus musculus (Mouse)|
          Length = 1286

 Score = 36.6 bits (83), Expect = 0.86
 Identities = 47/200 (23%), Positives = 89/200 (44%), Gaps = 4/200 (2%)
 Frame = +2

Query: 110  RYMATSDLLSELNKESFKADQDLESKLTNIVLQQLEDASGDVSGLAVKCLAPLVKKVSEE 289
            R +A  +L+    +ESF    +    +  ++L+ L D    +  LA+K L  +++     
Sbjct: 1069 RKIALYELMKLTQEESFSVWDEHFKTILLLLLETLGDKEPTIRALALKVLKEILRH-QPA 1127

Query: 290  RVVEMTDKLCDKLLNG-KDQHRDTASIALKAVIVEVTTASLSEKILVSLAPQLIKGVTSG 466
            R     +    K L   KD H++    A +A  V  T+ S  + I V L P +       
Sbjct: 1128 RFKNYAELTVMKTLEAHKDPHKEVVRSAEEAASVLATSISPEQCIKV-LCPIIQTADYPI 1186

Query: 467  KSAEIKCECLDILGDVLHRFGNVITKDHAYMLTALLAQLSSTQASVRKKSVSCIASLAPC 646
              A IK +   ++  V     N++  +   ++  L+    ++++SVRK  V C+ ++   
Sbjct: 1187 NLAAIKMQT-KVIERVSKETLNMLLPE---IMPGLIQGYDNSESSVRKACVFCLVAVHAV 1242

Query: 647  LSDDL---LAKGTLEVVKLL 697
            + D+L   L++ T   +KLL
Sbjct: 1243 IGDELKPHLSQLTGSKMKLL 1262

>O75122:CLAP2_HUMAN CLIP-associating protein 2 - Homo sapiens (Human)|
          Length = 1294

 Score = 36.6 bits (83), Expect = 0.86
 Identities = 47/200 (23%), Positives = 89/200 (44%), Gaps = 4/200 (2%)
 Frame = +2

Query: 110  RYMATSDLLSELNKESFKADQDLESKLTNIVLQQLEDASGDVSGLAVKCLAPLVKKVSEE 289
            R +A  +L+    +ESF    +    +  ++L+ L D    +  LA+K L  +++     
Sbjct: 1077 RKIALYELMKLTQEESFSVWDEHFKTILLLLLETLGDKEPTIRALALKVLREILRH-QPA 1135

Query: 290  RVVEMTDKLCDKLLNG-KDQHRDTASIALKAVIVEVTTASLSEKILVSLAPQLIKGVTSG 466
            R     +    K L   KD H++    A +A  V  T+ S  + I V L P +       
Sbjct: 1136 RFKNYAELTVMKTLEAHKDPHKEVVRSAEEAASVLATSISPEQCIKV-LCPIIQTADYPI 1194

Query: 467  KSAEIKCECLDILGDVLHRFGNVITKDHAYMLTALLAQLSSTQASVRKKSVSCIASLAPC 646
              A IK +   ++  V     N++  +   ++  L+    ++++SVRK  V C+ ++   
Sbjct: 1195 NLAAIKMQT-KVIERVSKETLNLLLPE---IMPGLIQGYDNSESSVRKACVFCLVAVHAV 1250

Query: 647  LSDDL---LAKGTLEVVKLL 697
            + D+L   L++ T   +KLL
Sbjct: 1251 IGDELKPHLSQLTGSKMKLL 1270

>Q10105:YAQ5_SCHPO Putative translational activator C18G6.05c - Schizosaccharomyces|
            pombe (Fission yeast)
          Length = 2670

 Score = 36.2 bits (82), Expect = 1.1
 Identities = 81/428 (18%), Positives = 165/428 (38%), Gaps = 31/428 (7%)
 Frame = +2

Query: 746  IGALSRSVGYRFGPHLAEAVPLLINYCTSASENDEELREYSLQALESFMLRCPR-DISPY 922
            + A SR +G  F P+L + +PLL+   TS  +N  E+RE ++ A++  M +     +   
Sbjct: 1426 VEAFSRILGIYFEPYLPDLLPLLL---TSFGDNANEVREATMDAVKQIMSQLSAFGVKLL 1482

Query: 923  CEGILNLALEYVSYDPNFXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXASWKVRRASAKC 1102
               +L+   EY                                      +W+ ++AS + 
Sbjct: 1483 LPTLLDGLNEY--------------------------------------NWRSKKASVEI 1504

Query: 1103 ISAIIVSRPQMLSKMYQEACPKLVDRFREREENVKMDIFNTFIELLRQTGNVTKGQGDID 1282
            +  +    P+ LS       PKL +   +    V+    NT  + L + G+V        
Sbjct: 1505 LGLMSYMAPKQLSVFLPTIIPKLSEVLTDSHSQVR----NTANKSLLRFGDVI------- 1553

Query: 1283 ESSPRWLLKQEVPKIVKSINRQLR------EKSIKTKVGAFSVLKELVVVLP-------- 1420
             S+P   ++  VP ++K+++   R      E  +KT    +     L +V+P        
Sbjct: 1554 -SNPE--IQTLVPTLLKALSDCTRYTDDALEALLKTSFVHYLDPPSLALVIPILKYGLRE 1610

Query: 1421 -DCLADQFGSLVPGIEKALNDKSSTSNLKIEALAFTRIVMASHSPSVFHPYIQALSGPIL 1597
             +    +  + + G+  +L +  + +      +   R V+    P       +AL G ++
Sbjct: 1611 RNAGTKRQSAKIFGLMASLTEPENLAVYLESLMPRLREVLIDPVPDTRATAAKAL-GSLI 1669

Query: 1598 SAIGDRYYKVTAEALRVCGELVRVLRPNFQAHSIDFRPYISPIYKAI----LARLAN--- 1756
              +G++ +        +  EL  VLR   +   +D +     + + +    LARL +   
Sbjct: 1670 EKLGEKKFPT------LIPELFNVLRS--ECSEVDRQGAAQGLSEILAGLGLARLEDVLP 1721

Query: 1757 ------QDQDQEVKECAISCMSLVIATFGDGLQRELPACLPILVDRMG--NEITRLTAVK 1912
                        ++E  IS +  + ATFG   Q  L   +P ++  +   +E+ +  +++
Sbjct: 1722 EILKNTSSPVPHIRESFISLLIYLPATFGSRFQPYLARAIPPILSGLADDSELVQTASLR 1781

Query: 1913 AFAVIANS 1936
            A  +I N+
Sbjct: 1782 AAKMIVNN 1789

>Q9GM44:HEAT1_MACFA HEAT repeat-containing protein 1 - Macaca fascicularis (Crab eating|
            macaque) (Cynomolgus monkey)
          Length = 958

 Score = 36.2 bits (82), Expect = 1.1
 Identities = 27/100 (27%), Positives = 45/100 (45%)
 Frame = +2

Query: 593  QASVRKKSVSCIASLAPCLSDDLLAKGTLEVVKLLKNRKAKSDITRTNIQMIGALSRSVG 772
            Q  V K+ + CIA  +  ++DD L K  L    LLK R A   +    +  + AL+  + 
Sbjct: 852  QERVTKQLIPCIAQFSVAMADDSLWK-PLNYQILLKTRDASPKVRFAALITVLALAEKLK 910

Query: 773  YRFGPHLAEAVPLLINYCTSASENDEELREYSLQALESFM 892
              +   L E++P L        E  E   + ++Q LE+ +
Sbjct: 911  ENYIVLLPESIPFLAELMEDECEEVEHQCQKTIQQLETVL 950

>O43028:VAC8_SCHPO Vacuolar protein 8 - Schizosaccharomyces pombe (Fission yeast)|
          Length = 550

 Score = 35.4 bits (80), Expect = 1.9
 Identities = 31/74 (41%), Positives = 39/74 (52%), Gaps = 2/74 (2%)
 Frame = +2

Query: 2516 STNSAKQHMALLCLGEIGRRKDLSNHDQIENI--VIESFQSPFEEIKSAASYALGNIAVG 2689
            S N   Q  A L   EI   KD+   D+ E I  V+   QSP  EI+ AAS ALGN+AV 
Sbjct: 58   SDNLDLQRSAALAFAEI-TEKDVREVDR-ETIEPVLFLLQSPDAEIQRAASVALGNLAVN 115

Query: 2690 NLSKYLPFILDQID 2731
              +K L   L+ +D
Sbjct: 116  AENKALVVKLNGLD 129

>O21037:RM06_DICDI Mitochondrial 60S ribosomal protein L6 - Dictyostelium discoideum|
           (Slime mold)
          Length = 170

 Score = 35.4 bits (80), Expect = 1.9
 Identities = 32/112 (28%), Positives = 54/112 (48%), Gaps = 12/112 (10%)
 Frame = +2

Query: 416 KILVSLAPQLIKGVTSGKSAEIKCECLDILGDVLHRFGNVITKDHAY-------MLTALL 574
           +I++    Q I+GV +G   E+K   L  LG V+H+ GN +  D  Y       +   ++
Sbjct: 60  RIIIGTMKQQIQGVLAGFCIELK---LVGLGFVVHKVGNTLVLDVGYSHYRSCLIPKEVV 116

Query: 575 AQLSSTQA---SVRKKSVSCIASLAPCLSDDLLAKGT--LEVVKLLKNRKAK 715
            +L  +Q    S+ K+ V+  ASL        + KGT  L + + +K +K K
Sbjct: 117 VKLEGSQIILYSINKEKVTTFASLLKTFKKINMYKGTGILGINEKIKLKKGK 168

>Q7Z460:CLAP1_HUMAN CLIP-associating protein 1 - Homo sapiens (Human)|
          Length = 1538

 Score = 35.0 bits (79), Expect = 2.5
 Identities = 45/232 (19%), Positives = 101/232 (43%), Gaps = 8/232 (3%)
 Frame = +2

Query: 65   ITGILEKMTGKDK--DYRYMATSDLLSELNKESFKADQDLESKLTNIVLQQLEDASGDVS 238
            +  +L++++  ++  + R  A  +LL    ++S    ++    +  ++L+ L D    + 
Sbjct: 1304 VADLLKELSNHNERVEERKGALLELLKITREDSLGVWEEHFKTILLLLLETLGDKDHSIR 1363

Query: 239  GLAVKCLAPLVKKVSE--ERVVEMTDKLCDKLLNGKDQHRDTASIALKAVIVEVTTASLS 412
             LA++ L  +++      +   E+T  +   L   KD H++    A      E   ++L+
Sbjct: 1364 ALALRVLREILRNQPARFKNYAELT--IMKTLEAHKDSHKEVVRAA------EEAASTLA 1415

Query: 413  EKILVSLAPQLIKGVTSGKSAEIKCECLDILGDVLHRFGNV-ITKDHAYMLTALLAQLSS 589
              I      +++  +       I    + +   V+ R     + +    ++  LL    +
Sbjct: 1416 SSIHPEQCIKVLCPIIQTADYPINLAAIKMQTKVVERIAKESLLQLLVDIIPGLLQGYDN 1475

Query: 590  TQASVRKKSVSCIASLAPCLSDDL---LAKGTLEVVKLLKNRKAKSDITRTN 736
            T++SVRK SV C+ ++   + +DL   LA+ T   +KLL     ++  T +N
Sbjct: 1476 TESSVRKASVFCLVAIYSVIGEDLKPHLAQLTGSKMKLLNLYIKRAQTTNSN 1527

>Q95YF0:CLAP1_CAEEL Protein CLASP-1 - Caenorhabditis elegans|
          Length = 1378

 Score = 34.7 bits (78), Expect = 3.3
 Identities = 31/142 (21%), Positives = 63/142 (44%), Gaps = 1/142 (0%)
 Frame = +2

Query: 1067 ASWKVRRASAKCISAIIVSRPQMLSKMYQEACPKLVDRFREREENVKMDIFNTFIELLRQ 1246
            +++KV     + + A + + P +L+  Y + C  L++R  + +  V+    N  ++L   
Sbjct: 57   SNFKVSTIGLEILDAALRTSPDVLASYYFDRCSVLIERMGDAKVQVREMAINLCLQLAY- 115

Query: 1247 TGNVTKGQGDIDESSPRWLLKQE-VPKIVKSINRQLREKSIKTKVGAFSVLKELVVVLPD 1423
                      ++ SSP  LL +  VP          + K    KVG+ ++L+E +     
Sbjct: 116  ----------LENSSPVMLLDRLCVP------GTGFQHKQWLVKVGSLNILREFLSSSFA 159

Query: 1424 CLADQFGSLVPGIEKALNDKSS 1489
             +  Q  +L+P + +  ND +S
Sbjct: 160  LVIQQAITLIPQLCRLTNDPNS 181

>Q9JKK8:ATR_MOUSE Serine/threonine-protein kinase ATR - Mus musculus (Mouse)|
          Length = 2635

 Score = 34.7 bits (78), Expect = 3.3
 Identities = 28/131 (21%), Positives = 57/131 (43%), Gaps = 9/131 (6%)
 Frame = +2

Query: 2582 LSNHDQIENIVIESFQSP----FEEIKSAAS-YALGNIAVGNLSKYLPFILDQIDNQQKK 2746
            + N D +++ + E +  P     E+IK+    Y        +L   L   +  I ++   
Sbjct: 1239 IENRDAVQDFLHEIYFLPDHPELEKIKAVLQEYRKETSETTDLQTTLQLSMKAIQHENVD 1298

Query: 2747 QYL-LLHSLKEVIARQS---VDHTGQSELQDSNILKILALLFNHCESEEEGVRNVVAECL 2914
              +  L SLKE + +     + +   SE  +  I +++ ++   C+      R +  ECL
Sbjct: 1299 VRIHALTSLKETLYKNQEKLIKYATDSETVEPVISQLVTVILKGCQDANSQARLLCGECL 1358

Query: 2915 GKIALIEPNKL 2947
            G++  I+P +L
Sbjct: 1359 GELGAIDPGRL 1369

>Q13535:ATR_HUMAN Serine/threonine-protein kinase ATR - Homo sapiens (Human)|
          Length = 2644

 Score = 34.7 bits (78), Expect = 3.3
 Identities = 18/66 (27%), Positives = 33/66 (50%), Gaps = 3/66 (4%)
 Frame = +2

Query: 2759 LHSLKEVIARQS---VDHTGQSELQDSNILKILALLFNHCESEEEGVRNVVAECLGKIAL 2929
            L SLKE + +     + +   SE  +  I +++ +L   C+      R +  ECLG++  
Sbjct: 1304 LTSLKETLYKNQEKLIKYATDSETVEPIISQLVTVLLKGCQDANSQARLLCGECLGELGA 1363

Query: 2930 IEPNKL 2947
            I+P +L
Sbjct: 1364 IDPGRL 1369

>Q6BTZ4:VAC8_DEBHA Vacuolar protein 8 - Debaryomyces hansenii (Yeast) (Torulaspora|
            hansenii)
          Length = 560

 Score = 34.3 bits (77), Expect = 4.2
 Identities = 28/66 (42%), Positives = 35/66 (53%), Gaps = 2/66 (3%)
 Frame = +2

Query: 2516 STNSAKQHMALLCLGEIGRRKDLS--NHDQIENIVIESFQSPFEEIKSAASYALGNIAVG 2689
            S N   Q  A L   EI   KD+   N D +E I+I   QS   E++ AA  ALGN+AV 
Sbjct: 60   SENIDLQRSAALAFAEI-TEKDVREVNRDVLEPILI-LLQSADSEVQRAACGALGNLAVN 117

Query: 2690 NLSKYL 2707
            N +K L
Sbjct: 118  NENKIL 123

>Q9H583:HEAT1_HUMAN HEAT repeat-containing protein 1 - Homo sapiens (Human)|
          Length = 2144

 Score = 34.3 bits (77), Expect = 4.2
 Identities = 26/100 (26%), Positives = 44/100 (44%)
 Frame = +2

Query: 593  QASVRKKSVSCIASLAPCLSDDLLAKGTLEVVKLLKNRKAKSDITRTNIQMIGALSRSVG 772
            Q  V K  + CIA  +  ++DD L K  L    LLK R +   +    +  + AL+  + 
Sbjct: 2038 QERVTKHLIPCIAQFSVAMADDSLWK-PLNYQILLKTRDSSPKVRFAALITVLALAEKLK 2096

Query: 773  YRFGPHLAEAVPLLINYCTSASENDEELREYSLQALESFM 892
              +   L E++P L        E  E   + ++Q LE+ +
Sbjct: 2097 ENYIVLLPESIPFLAELMEDECEEVEHQCQKTIQQLETVL 2136

>Q67ES1:TR113_RAT Taste receptor type 2 member 113 - Rattus norvegicus (Rat)|
          Length = 309

 Score = 33.9 bits (76), Expect = 5.5
 Identities = 20/57 (35%), Positives = 28/57 (49%)
 Frame = -1

Query: 1723 WTNIRPEIY*MCLEVWTEHPD*LPAHT*SLSSDFVISISNSR*YWTGQCLDVWMKHR 1553
            W++  PE Y + L VW      LPAHT      FV+   N R  W    L +W+++R
Sbjct: 253  WSSGSPERYLIFLFVWALGNAVLPAHT------FVLIWGNCRLRWASLSLMLWLRYR 303

>Q6BKA6:DOHH_DEBHA Deoxyhypusine hydroxylase - Debaryomyces hansenii (Yeast)|
            (Torulaspora hansenii)
          Length = 311

 Score = 33.9 bits (76), Expect = 5.5
 Identities = 26/93 (27%), Positives = 46/93 (49%), Gaps = 4/93 (4%)
 Frame = +2

Query: 2474 STIEMLKGIL-NDDSSTNSAKQHMALLCLGEIGRRKDLSNHDQIE---NIVIESFQSPFE 2641
            +T+E L+ +L N       A +  AL  L  +G   +  N D++    + + ESF+   E
Sbjct: 10   ATLEQLRDVLTNKSGDVKLANRFRALFNLKCVGAESE--NQDEVHKAIDYIAESFKDDSE 67

Query: 2642 EIKSAASYALGNIAVGNLSKYLPFILDQIDNQQ 2740
             +K   +Y LG     + ++YL  +L+  +NQQ
Sbjct: 68   LLKHEVAYVLGQTKNLHAAQYLRSVLEN-NNQQ 99

>Q6C5Y8:VAC8_YARLI Vacuolar protein 8 - Yarrowia lipolytica (Candida lipolytica)|
          Length = 573

 Score = 33.1 bits (74), Expect = 9.5
 Identities = 26/66 (39%), Positives = 36/66 (54%), Gaps = 2/66 (3%)
 Frame = +2

Query: 2516 STNSAKQHMALLCLGEIGRRKDLS--NHDQIENIVIESFQSPFEEIKSAASYALGNIAVG 2689
            S N   Q  A L   EI   KD+   N D +E +++   Q+   +I+ AAS ALGN+AV 
Sbjct: 81   SDNIDLQRSAALAFAEI-TEKDIRPVNRDCLEPVLL-LLQNTDPDIQRAASAALGNLAVN 138

Query: 2690 NLSKYL 2707
            N +K L
Sbjct: 139  NENKVL 144

>P38873:KOG1_YEAST Target of rapamycin complex 1 subunit KOG1 - Saccharomyces cerevisiae|
            (Baker's yeast)
          Length = 1557

 Score = 33.1 bits (74), Expect = 9.5
 Identities = 49/249 (19%), Positives = 107/249 (42%), Gaps = 9/249 (3%)
 Frame = +2

Query: 2408 ALFSIAQCVAVLCLAAGDKKCASTIEMLKGILNDDSSTNSAKQHMALLCLGEIGRRKDLS 2587
            A+F +A  V    L  G K C S   + K     D+S     +   ++ LG +     L+
Sbjct: 716  AVFVLASFVRNFPL--GQKNCFSLELVNKLCFYIDNSEIPLLRQWCVILLGLLFADNPLN 773

Query: 2588 -----NHDQIENIVIESFQSPFEEIKSAASYALGNIAVGNLSKYLPFILDQIDNQQKKQY 2752
                 N   +E I+++S + P  E+++A+ +AL +   G     +   L Q   + ++QY
Sbjct: 774  RFVCMNTGAVE-ILLKSLKDPVPEVRTASIFALKHFISGFQDAEVILRLQQ---EFEEQY 829

Query: 2753 LLLHSLKEVIARQSVDHTGQSELQDSNI----LKILALLFNHCESEEEGVRNVVAECLGK 2920
              LHS  + +  QS     QS+ Q  ++    +KI   +  HC+  +  +  +    L +
Sbjct: 830  QQLHSQLQHLQNQSHLQQQQSQQQQQHLEQQQMKIEKQI-RHCQVMQNQLEVIDLRKLKR 888

Query: 2921 IALIEPNKLIPALKERTSSPAANTRATVAIAIKYSIVERTGKIDAILYSEISTFLMLIKD 3100
              +     ++P + + +S      R  + +   + +   +     ++++++   + L++ 
Sbjct: 889  QEIGNLISILPLINDGSSL----VRKELVVYFSHIVSRYSNFFIVVVFNDLLEEIKLLEK 944

Query: 3101 SDRHVRRAA 3127
            SD + R  +
Sbjct: 945  SDINTRNTS 953

>Q6FRW0:ATPF_CANGA ATP synthase subunit 4, mitochondrial precursor - Candida glabrata|
           (Yeast) (Torulopsis glabrata)
          Length = 242

 Score = 33.1 bits (74), Expect = 9.5
 Identities = 40/160 (25%), Positives = 74/160 (46%), Gaps = 2/160 (1%)
 Frame = +2

Query: 236 SGLAVKCLAPLVKKVSEERVVEMTDKLCDKLLNGKDQHRDTASIALKAVIVEVTTASLSE 415
           SGL  K LAPL K  ++ R+     K+   L + +++H D     +++V  E+   S + 
Sbjct: 99  SGLVAKFLAPLYKDFADARI----KKIGSILNSSRERHVDAVKDRIESV-SELQNVSETT 153

Query: 416 KILVSLAPQLIKGVTSGKSAEIKCECLDILGDVLHRFGNVITKDHAYMLTALLAQLSSTQ 595
           K+L  ++ + ++     K+ E+K +      ++ H   +V+  D      A L QL   Q
Sbjct: 154 KVLFDVSKETVE--LEAKAFELKQKV-----ELAHEAKSVL--DSWVRYEASLRQLQ--Q 202

Query: 596 ASVRKKSVSCIAS--LAPCLSDDLLAKGTLEVVKLLKNRK 709
             + +  +S + S    P   D +L +   EV ++L N K
Sbjct: 203 KQIAEGIISKVESELTNPKFQDRVLQQSIAEVEQVLANIK 242


  Database: uniprot_sprot.fasta.out
    Posted date:  Jul 19, 2007  5:58 PM
  Number of letters in database: 100,686,439
  Number of sequences in database:  274,295
  
Lambda     K      H
   0.318    0.134    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 274295
Number of Hits to DB: 658,013,709
Number of extensions: 13722673
Number of successful extensions: 34747
Number of sequences better than 10.0: 33
Number of HSP's gapped: 34671
Number of HSP's successfully gapped: 41
Length of query: 1316
Length of database: 100,686,439
Length adjustment: 125
Effective length of query: 1191
Effective length of database: 66,399,564
Effective search space: 79081880724
Effective search space used: 79081880724
Neighboring words threshold: 12
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)