ナショナルバイオリソースプロジェクト
-Barley Genetic Resources Database-
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| Clone Name | FLbaf110l01 |
|---|---|
| Clone Library Name | barley_pub |
>Q7XU38:C87A3_ORYSJ Cytochrome P450 87A3 - Oryza sativa subsp. japonica (Rice)| Length = 514 Score = 550 bits (1417), Expect = e-156 Identities = 258/480 (53%), Positives = 357/480 (74%), Gaps = 3/480 (0%) Frame = +1 Query: 64 SQVAFASLCG-LAAVVAGWLAHCVYKWTNPACSTGRLPPGSMGLPLVGETFQFFKPSPSL 240 S A LC LAAVVA L Y+W++P S GRLPPGS+GLP++GET QFF P+P+ Sbjct: 38 SMAYIALLCAALAAVVA--LLRWAYRWSHPR-SNGRLPPGSLGLPVIGETLQFFAPNPTC 94 Query: 241 DVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEVNRFIFQQEGKLFRSWYPDTANNIFGK 420 D+ F K+R+KRYG +FKTS+VG+PVVVS D E+N ++FQQEGKLF SWYPDT IFG+ Sbjct: 95 DLSPFVKERIKRYGSIFKTSVVGRPVVVSADPEMNYYVFQQEGKLFESWYPDTFTEIFGR 154 Query: 421 ESIASYDGSFHKYVRSFASRLFGLDSLRDVLLAEMDCNVTDSLAAWAAEPAIEVKDAVAN 600 +++ S G +KY+++ RL+G ++L+ VLLAE D SLA+WA++P++E+K+ ++ Sbjct: 155 DNVGSLHGFMYKYLKTLVLRLYGQENLKSVLLAETDAACRGSLASWASQPSVELKEGIST 214 Query: 601 MVFDLTAKKLIGFSPEKSRK--LRKNFDAFFQGLVSFPLYFPGTTFYRCIQGRKNVQKVL 774 M+FDLTAKKLIG+ P K + LRKNF AF GL+SFPL PGT ++ C++GRKN KVL Sbjct: 215 MIFDLTAKKLIGYDPSKPSQVNLRKNFGAFICGLISFPLNIPGTAYHECMEGRKNAMKVL 274 Query: 775 KDLLKERLGAPEKRHGDFLDEVVDELQSGRGVIDEKFAVDLMAALLFASFATVSSSLTIA 954 + ++KER+ PE+ DF D V+ EL+ + ++ E A+DLM LLFASF T + +LTI Sbjct: 275 RGMMKERMAEPERPCEDFFDHVIQELRREKPLLTETIALDLMFVLLFASFETTALALTIG 334 Query: 955 MKFLSGHPNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAPG 1134 +K L+ +P VV++L+EEHEAI++ R++ SG+TW EYKSMTFT+QV EI R++N+ PG Sbjct: 335 VKLLTENPKVVDALREEHEAIIRNRKD-PNSGVTWAEYKSMTFTSQVIMEIVRLANIVPG 393 Query: 1135 IFRKTLTDVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNF 1314 IFRK L DV++KGYTIPAGW +M+ P AVHLNPE++EDPL FNPWRWQ + + + K+F Sbjct: 394 IFRKALQDVEIKGYTIPAGWGIMVCPPAVHLNPEIYEDPLAFNPWRWQGKPEITGGTKHF 453 Query: 1315 MPFGGGIRLCVGAEFSRIQIALFLHTLVTKYRWKEIKGGEVQRISEIVFPEGYHIQIIPR 1494 M FGGG+R CVG + S++ +A F+H+LVTKY W+ +KGG + R + FP+G+HIQ+ P+ Sbjct: 454 MAFGGGLRFCVGTDLSKVLMATFIHSLVTKYSWRTVKGGNIVRTPGLSFPDGFHIQLFPK 513
>Q42569:C90A1_ARATH Cytochrome P450 90A1 - Arabidopsis thaliana (Mouse-ear cress)| Length = 472 Score = 308 bits (788), Expect = 6e-83 Identities = 168/416 (40%), Positives = 238/416 (57%), Gaps = 1/416 (0%) Frame = +1 Query: 169 LPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEVNR 348 LPPGS+GLPL+GETFQ + + F +R+ RYG VF T L G+P + S D E NR Sbjct: 31 LPPGSLGLPLIGETFQLIGAYKTENPEPFIDERVARYGSVFMTHLFGEPTIFSADPETNR 90 Query: 349 FIFQQEGKLFRSWYPDTANNIFGKESIASYDGSFHKYVRSFASRLFGLDSLRDVLLAEMD 528 F+ Q EGKLF YP + N+ GK S+ GS HK + S ++D L+ ++D Sbjct: 91 FVLQNEGKLFECSYPASICNLLGKHSLLLMKGSLHKRMHSLTMSFANSSIIKDHLMLDID 150 Query: 529 CNVTDSLAAWAAEPAIEVKDAVANMVFDLTAKKLIGFSP-EKSRKLRKNFDAFFQGLVSF 705 V +L +W++ + + + + F+LT K+L+ F P E S LRK + +G S Sbjct: 151 RLVRFNLDSWSSR--VLLMEEAKKITFELTVKQLMSFDPGEWSESLRKEYLLVIEGFFSL 208 Query: 706 PLYFPGTTFYRCIQGRKNVQKVLKDLLKERLGAPEKRHGDFLDEVVDELQSGRGVIDEKF 885 PL TT+ + IQ R+ V + L ++ +R E+ D + L + G DE+ Sbjct: 209 PLPLFSTTYRKAIQARRKVAEALTVVVMKRREEEEEGAERKKDMLAALLAADDGFSDEEI 268 Query: 886 AVDLMAALLFASFATVSSSLTIAMKFLSGHPNVVESLKEEHEAILKKREEGAKSGITWEE 1065 VD + ALL A + T S+ +T+A+KFL+ P + LKEEHE I + + + W + Sbjct: 269 -VDFLVALLVAGYETTSTIMTLAVKFLTETPLALAQLKEEHEKIRAMKSDSYS--LEWSD 325 Query: 1066 YKSMTFTAQVTNEISRVSNVAPGIFRKTLTDVQVKGYTIPAGWLVMISPMAVHLNPELFE 1245 YKSM FT V NE RV+N+ G+FR+ +TDV++KGY IP GW V S AVHL+P F+ Sbjct: 326 YKSMPFTQCVVNETLRVANIIGGVFRRAMTDVEIKGYKIPKGWKVFSSFRAVHLDPNHFK 385 Query: 1246 DPLTFNPWRWQDESKKSTMLKNFMPFGGGIRLCVGAEFSRIQIALFLHTLVTKYRW 1413 D TFNPWRWQ S + F PFGGG RLC G E +R+ +++FLH LVT + W Sbjct: 386 DARTFNPWRWQSNSVTTGPSNVFTPFGGGPRLCPGYELARVALSVFLHRLVTGFSW 441
>Q43147:C85A1_SOLLC Cytochrome P450 85A1 - Solanum lycopersicum (Tomato) (Lycopersicon| esculentum) Length = 464 Score = 293 bits (750), Expect = 2e-78 Identities = 159/451 (35%), Positives = 258/451 (57%), Gaps = 1/451 (0%) Frame = +1 Query: 136 KWTNPACSTGRLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQP 315 +W + LPPG+MG PL GET +F K PS F K + RYG FK+ ++G P Sbjct: 23 RWNQVKYNQKNLPPGTMGWPLFGETTEFLKLGPS-----FMKNQRARYGSFFKSHILGCP 77 Query: 316 VVVSMDAEVNRFIFQQEGKLFRSWYPDTANNIFGKESIASYDGSFHKYVRSFASRLFGLD 495 +VSMD+E+NR+I E K YP + +I GK +IA+ +GS HKY+R L Sbjct: 78 TIVSMDSELNRYILVNEAKGLVPGYPQSMIDILGKCNIAAVNGSAHKYMRGALLSLISPT 137 Query: 496 SLRDVLLAEMDCNVTDSLAAWAAEPAIEVKDAVANMVFDLTAKKLIGF-SPEKSRKLRKN 672 +RD LL ++D + L W + I++++ M F + K++ G S +++ Sbjct: 138 MIRDQLLPKIDEFMRSHLTNWDNK-VIDIQEKTNKMAFLSSLKQIAGIESTSLAQEFMSE 196 Query: 673 FDAFFQGLVSFPLYFPGTTFYRCIQGRKNVQKVLKDLLKERLGAPEKRHGDFLDEVVDEL 852 F G +S P+ P T ++R Q RK + +L+ L++ER + E +H D L +++E Sbjct: 197 FFNLVLGTLSLPINLPNTNYHRGFQARKIIVNLLRTLIEERRASKEIQH-DMLGYLMNEE 255 Query: 853 QSGRGVIDEKFAVDLMAALLFASFATVSSSLTIAMKFLSGHPNVVESLKEEHEAILKKRE 1032 + + D++ +DL+ +L++ + TVS++ +A+K+L HP V+E L++EH AI +K++ Sbjct: 256 ATRFKLTDDEM-IDLIITILYSGYETVSTTSMMAVKYLHDHPKVLEELRKEHMAIREKKK 314 Query: 1033 EGAKSGITWEEYKSMTFTAQVTNEISRVSNVAPGIFRKTLTDVQVKGYTIPAGWLVMISP 1212 + I + +Y+SM FT V E SR++ + G+ RKT D+++ GY IP GW + + Sbjct: 315 P--EDPIDYNDYRSMRFTRAVILETSRLATIVNGVLRKTTQDMEINGYIIPKGWRIYVYT 372 Query: 1213 MAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGIRLCVGAEFSRIQIALFLHT 1392 ++ +P L+ DP +FNPWRW D+S + +F+ FGGG R C G E +I+ FLH Sbjct: 373 RELNYDPRLYPDPYSFNPWRWMDKSLEHQ--NSFLVFGGGTRQCPGKELGVAEISTFLHY 430 Query: 1393 LVTKYRWKEIKGGEVQRISEIVFPEGYHIQI 1485 VTKYRW+EI G ++ + + P G I++ Sbjct: 431 FVTKYRWEEIGGDKLMKFPRVEAPNGLRIRV 461
>Q8GSQ1:C85A1_ORYSJ Cytochrome P450 85A1 - Oryza sativa subsp. japonica (Rice)| Length = 469 Score = 291 bits (745), Expect = 6e-78 Identities = 162/470 (34%), Positives = 258/470 (54%), Gaps = 5/470 (1%) Frame = +1 Query: 91 GLAAVVAGWLAHCVYKWTNPACSTGR-LPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQR 267 G+ A ++ + +W S R LPPG+MG PL GET +F K PS F K R Sbjct: 7 GVVVAAAVVVSSLLLRWNEVRYSRKRGLPPGTMGWPLFGETTEFLKQGPS-----FMKAR 61 Query: 268 LKRYGPVFKTSLVGQPVVVSMDAEVNRFIFQQEGKLFRSWYPDTANNIFGKESIASYDGS 447 RYG VF+T ++G P VV M+AE+NR EG+ F YP + +I G+ +IA+ G Sbjct: 62 RLRYGSVFRTHILGCPTVVCMEAELNRRALASEGRGFVPGYPQSMLDILGRNNIAAVQGP 121 Query: 448 FHKYVRSFASRLFGLDSLRDVLLAEMDCNVTDSLAAWAAEPAIEVKDAVAN---MVFDLT 618 H+ +R L +R LL ++D + LAAW++ + V D A M Sbjct: 122 LHRAMRGAMLSLVRPAMIRSSLLPKIDAFMRSHLAAWSSSSSSAVVDIQAKTKEMALLSA 181 Query: 619 AKKLIGFSPEK-SRKLRKNFDAFFQGLVSFPLYFPGTTFYRCIQGRKNVQKVLKDLLKER 795 +++ G S S L+ G +S P+ PGT +Y+ + RK + +L+ ++ ER Sbjct: 182 LRQIAGVSAGPLSDALKAELYTLVLGTISLPINLPGTNYYQGFKARKKLVAMLEQMIAER 241 Query: 796 LGAPEKRHGDFLDEVVDELQSGRGVIDEKFAVDLMAALLFASFATVSSSLTIAMKFLSGH 975 + + H D LD ++ ++ R + ++ +DL+ L+++ + T+S++ +A+K+LS H Sbjct: 242 RSSGQV-HDDMLDALLTGVEGTREKLTDEQIIDLIITLIYSGYETMSTTSMMAVKYLSDH 300 Query: 976 PNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAPGIFRKTLT 1155 P +E L++EH I K + + I W ++KSMTFT V E R++ V G+ RKT Sbjct: 301 PKALEQLRKEHFDIRKGK--APEDAIDWNDFKSMTFTRAVIFETLRLATVVNGLLRKTTQ 358 Query: 1156 DVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGI 1335 DV++ GY IP GW + + ++ +P L+ DP+TFNPWRW +++ +S +FM FGGG Sbjct: 359 DVEMNGYVIPKGWRIYVYTREINYDPFLYPDPMTFNPWRWLEKNMESH--PHFMLFGGGS 416 Query: 1336 RLCVGAEFSRIQIALFLHTLVTKYRWKEIKGGEVQRISEIVFPEGYHIQI 1485 R+C G E ++IA FLH VT+YRW+E + + + P G HI++ Sbjct: 417 RMCPGKEVGTVEIATFLHYFVTQYRWEEEGNNTILKFPRVEAPNGLHIRV 466
>O64989:C90B1_ARATH Cytochrome P450 90B1 - Arabidopsis thaliana (Mouse-ear cress)| Length = 513 Score = 288 bits (738), Expect = 4e-77 Identities = 157/471 (33%), Positives = 252/471 (53%), Gaps = 32/471 (6%) Frame = +1 Query: 169 LPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEVNR 348 LPPG G P +GET + KP + + F +Q + +YG +++++L G+P +VS DA +NR Sbjct: 39 LPPGKSGWPFLGETIGYLKPYTATTLGDFMQQHVSKYGKIYRSNLFGEPTIVSADAGLNR 98 Query: 349 FIFQQEGKLFRSWYPDTANNIFGKESIASYDGSFHKYVRSFASRLFGLDSLRDVLLAEMD 528 FI Q EG+LF YP + I GK S+ G H+ +RS + LR +LL +++ Sbjct: 99 FILQNEGRLFECSYPRSIGGILGKWSMLVLVGDMHRDMRSISLNFLSHARLRTILLKDVE 158 Query: 529 CNVTDSLAAWAAEPAIEVKDAVANMVFDLTAKKLIGFSP--EKSRKLRKNFDAFFQGLVS 702 + L +W +D F+L AK ++ P E++ +L+K + F +G+VS Sbjct: 159 RHTLFVLDSWQQNSIFSAQDEAKKFTFNLMAKHIMSMDPGEEETEQLKKEYVTFMKGVVS 218 Query: 703 FPLYFPGTTFYRCIQGRKNVQKVLKDLLKER-LGAPEKRHGDFLDEVVDELQSGRGV--- 870 PL PGT +++ +Q R + K ++ ++ER L E+ + + DE + + Sbjct: 219 APLNLPGTAYHKALQSRATILKFIERKMEERKLDIKEEDQEEEEVKTEDEAEMSKSDHVR 278 Query: 871 -----------------IDEKFAVDLMAALLFASFATVSSSLTIAMKFLSGHPNVVESLK 999 + + +DL+ +LLFA T S ++ +A+ FL P VE L+ Sbjct: 279 KQRTDDDLLGWVLKHSNLSTEQILDLILSLLFAGHETSSVAIALAIFFLQACPKAVEELR 338 Query: 1000 EEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAPGIFRKTLTDVQVKGYT 1179 EEH I + ++E +S + W++YK M FT V NE R+ NV + RK L DV+ KGY Sbjct: 339 EEHLEIARAKKELGESELNWDDYKKMDFTQCVINETLRLGNVVRFLHRKALKDVRYKGYD 398 Query: 1180 IPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKK---------STMLKNFMPFGGG 1332 IP+GW V+ AVHL+ ++ P FNPWRWQ ++ ST N+MPFGGG Sbjct: 399 IPSGWKVLPVISAVHLDNSRYDQPNLFNPWRWQQQNNGASSSGSGSFSTWGNNYMPFGGG 458 Query: 1333 IRLCVGAEFSRIQIALFLHTLVTKYRWKEIKGGEVQRISEIVFPEGYHIQI 1485 RLC G+E +++++A+F+H LV K+ W+ + + + FP G I++ Sbjct: 459 PRLCAGSELAKLEMAVFIHHLVLKFNWELAEDDQPFAFPFVDFPNGLPIRV 509
>Q50LE0:C85A3_SOLLC Cytochrome P450 85A3 - Solanum lycopersicum (Tomato) (Lycopersicon| esculentum) Length = 467 Score = 281 bits (720), Expect = 5e-75 Identities = 147/454 (32%), Positives = 254/454 (55%), Gaps = 2/454 (0%) Frame = +1 Query: 130 VYKWTNPACSTGRLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVG 309 +++W + + LPPG+MG P+ GET +F P+ F K + RYG FK+ ++G Sbjct: 21 LFRWIDIVYNKKNLPPGTMGWPIFGETREFLNQGPN-----FMKNQRARYGNFFKSHILG 75 Query: 310 QPVVVSMDAEVNRFIFQQEGKLFRSWYPDTANNIFGKESIASYDGSFHKYVRSFASRLFG 489 P VVSMDA +N +I E K YP + +I GK +IA+ G+ HKY+R L Sbjct: 76 CPTVVSMDAGLNVYILNNEAKGLIPGYPQSMLDILGKCNIAAVHGATHKYIRGALLSLIN 135 Query: 490 LDSLRDVLLAEMDCNVTDSLAAWAAEPAIEVKDAVANMVFDLTAKKLIGFSPEKS--RKL 663 ++D +L ++D + L+ W I+++ M F + ++ GF+ S ++ Sbjct: 136 PTMIKDHILPKIDKFMRSHLSGWDNCNVIDIQQMTKEMAFFSSLDQIGGFATSSSIAQEF 195 Query: 664 RKNFDAFFQGLVSFPLYFPGTTFYRCIQGRKNVQKVLKDLLKERLGAPEKRHGDFLDEVV 843 R F G +S P+ FP T +YR +QGRK + K+L+ ++++R G+ +K D L ++ Sbjct: 196 RAGFLNIALGTISLPINFPTTNYYRGLQGRKTIVKLLRKIIEDRRGS-KKIQQDMLGLMM 254 Query: 844 DELQSGRGVIDEKFAVDLMAALLFASFATVSSSLTIAMKFLSGHPNVVESLKEEHEAILK 1023 +E R + ++ +D + ++++ F TVS++ +A+K+L HP +E +++EH AI + Sbjct: 255 NEEAKNRYTLSDEELIDQIITIMYSGFETVSTTSMMAVKYLHDHPKALEEIRKEHFAIRE 314 Query: 1024 KREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAPGIFRKTLTDVQVKGYTIPAGWLVM 1203 K+ + I + ++K+M FT V E R++ + G+ RKT D+++ GY IP GW + Sbjct: 315 KK--SLEDPIDYNDFKAMRFTRAVIYETLRLATIVNGVLRKTTQDMELNGYMIPKGWRIY 372 Query: 1204 ISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGIRLCVGAEFSRIQIALF 1383 + ++ +P ++ DP TFNPWRW + + +F+ FGGG RLC G E +I+ F Sbjct: 373 VYTRELNYDPLIYPDPYTFNPWRWLENNLDHQ--SSFLMFGGGTRLCPGKELGVAEISTF 430 Query: 1384 LHTLVTKYRWKEIKGGEVQRISEIVFPEGYHIQI 1485 LH VT+YRW+E+ G ++ + + G I++ Sbjct: 431 LHYFVTRYRWEEVGGNKLMKFPRVEALNGLWIKV 464
>Q9FMA5:C85A1_ARATH Cytochrome P450 85A1 - Arabidopsis thaliana (Mouse-ear cress)| Length = 465 Score = 281 bits (720), Expect = 5e-75 Identities = 163/482 (33%), Positives = 264/482 (54%), Gaps = 9/482 (1%) Frame = +1 Query: 73 AFASLCGLAAVVAGWLAHCVYKWTNPACSTGRLPPGSMGLPLVGETFQFFKPSPSLDVPA 252 A + GL ++ L + +W + LPPG+MG P+ GET +F K P+ Sbjct: 3 AMMVMMGLLLIIVS-LCSALLRWNQMRYTKNGLPPGTMGWPIFGETTEFLKQGPN----- 56 Query: 253 FYKQRLKRYGPVFKTSLVGQPVVVSMDAEVNRFIFQQEGKLFRSWYPDTANNIFGKESIA 432 F + + RYG FK+ L+G P ++SMD+EVNR+I + E K YP + +I G ++A Sbjct: 57 FMRNQRLRYGSFFKSHLLGCPTLISMDSEVNRYILKNESKGLVPGYPQSMLDILGTCNMA 116 Query: 433 SYDGSFHKYVRSFASRLFGLDSLRDVLLAEMDCNVTDSLAAWAAEPAIEVKDAVANMVFD 612 + GS H+ +R L +RD +L ++D + L W I+++D +M F Sbjct: 117 AVHGSSHRLMRGSLLSLISSTMMRDHILPKVDHFMRSYLDQWNELEVIDIQDKTKHMAFL 176 Query: 613 LTAKKLIGFSPEKSRKLRKNF-----DAFFQ---GLVSFPLYFPGTTFYRC-IQGRKNVQ 765 + ++ G LRK F AFF+ G +S P+ PGT YRC IQ R N+ Sbjct: 177 SSLTQIAG-------NLRKPFVEEFKTAFFKLVVGTLSVPIDLPGTN-YRCGIQARNNID 228 Query: 766 KVLKDLLKERLGAPEKRHGDFLDEVVDELQSGRGVIDEKFAVDLMAALLFASFATVSSSL 945 ++L++L++ER + E D L ++ + + + DE+ D + +L++ + TVS++ Sbjct: 229 RLLRELMQERRDSGET-FTDMLGYLMKKEGNRYPLTDEEIR-DQVVTILYSGYETVSTTS 286 Query: 946 TIAMKFLSGHPNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNV 1125 +A+K+L HP ++ L+ EH A +++ + G+ E+ KSM FT V E SR++ + Sbjct: 287 MMALKYLHDHPKALQELRAEHLAFRERKRQDEPLGL--EDVKSMKFTRAVIYETSRLATI 344 Query: 1126 APGIFRKTLTDVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTML 1305 G+ RKT D+++ GY IP GW + + ++ + L+EDPL FNPWRW +S +S Sbjct: 345 VNGVLRKTTRDLEINGYLIPKGWRIYVYTREINYDANLYEDPLIFNPWRWMKKSLESQ-- 402 Query: 1306 KNFMPFGGGIRLCVGAEFSRIQIALFLHTLVTKYRWKEIKGGEVQRISEIVFPEGYHIQI 1485 + FGGG RLC G E ++I+ FLH VT+YRW+EI G E+ + P+G+H++I Sbjct: 403 NSCFVFGGGTRLCPGKELGIVEISSFLHYFVTRYRWEEIGGDELMVFPRVFAPKGFHLRI 462 Query: 1486 IP 1491 P Sbjct: 463 SP 464
>Q69F95:C85A_PHAVU Cytochrome P450 85A - Phaseolus vulgaris (Kidney bean) (French bean)| Length = 466 Score = 280 bits (716), Expect = 1e-74 Identities = 156/451 (34%), Positives = 250/451 (55%), Gaps = 1/451 (0%) Frame = +1 Query: 136 KWTNPACSTGRLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQP 315 KW LPPG+MG P+ GET +F K P+ F K + RYG FK+ ++G P Sbjct: 23 KWNEVRFRRKGLPPGAMGWPVFGETTEFLKQGPN-----FMKNKRARYGSFFKSHILGCP 77 Query: 316 VVVSMDAEVNRFIFQQEGKLFRSWYPDTANNIFGKESIASYDGSFHKYVRSFASRLFGLD 495 +VSMD E+NRFI E K YP + +I G +IA+ GS HKY+R + Sbjct: 78 TIVSMDPELNRFILMNEAKGLVPGYPQSMLDILGTRNIAAVHGSTHKYMRGALLSIISPT 137 Query: 496 SLRDVLLAEMDCNVTDSLAAWAAEPAIEVKDAVANMVFDLTAKKLIGF-SPEKSRKLRKN 672 +RD LL ++D + L W + I +++ M F + K++ G S ++ Sbjct: 138 LIRDQLLPKIDEFMRTHLMDWDNK-VINIQEKTKEMAFLSSLKQIAGMESSSIAQPFMTE 196 Query: 673 FDAFFQGLVSFPLYFPGTTFYRCIQGRKNVQKVLKDLLKERLGAPEKRHGDFLDEVVDEL 852 F G +S P+ P T + +Q RK++ +L LL+ER A + H D L ++ + Sbjct: 197 FFKLVLGTLSLPINLPRTNYRGGLQARKSIISILSQLLEERK-ASQDVHVDMLGCLMKKD 255 Query: 853 QSGRGVIDEKFAVDLMAALLFASFATVSSSLTIAMKFLSGHPNVVESLKEEHEAILKKRE 1032 ++ + DE+ +DL+ ++++ + TVS++ +A+K+L HP V+E +++EH AI ++++ Sbjct: 256 ENRYKLSDEEI-IDLVITIMYSGYETVSTTSMMAVKYLHDHPKVLEEIRKEHFAIRERKK 314 Query: 1033 EGAKSGITWEEYKSMTFTAQVTNEISRVSNVAPGIFRKTLTDVQVKGYTIPAGWLVMISP 1212 + I + KSM FT V E SR++ + G+ RKT D+++ GY IP GW + + Sbjct: 315 P--EDPIDCNDLKSMRFTRAVIFETSRLATIVNGVLRKTTHDMELNGYLIPKGWRIYVYT 372 Query: 1213 MAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGIRLCVGAEFSRIQIALFLHT 1392 ++ +P L+ DPLTFNPWRW S +S +F+ FGGG R C G E +I+ FLH Sbjct: 373 REINYDPFLYHDPLTFNPWRWLGNSLESQ--SHFLIFGGGTRQCPGKELGIAEISTFLHY 430 Query: 1393 LVTKYRWKEIKGGEVQRISEIVFPEGYHIQI 1485 VT+YRW+E+ G ++ + +V P G HI++ Sbjct: 431 FVTRYRWEEVGGDKLMKFPRVVAPNGLHIRV 461
>Q9M066:C90C1_ARATH Cytochrome P450 90C1 - Arabidopsis thaliana (Mouse-ear cress)| Length = 524 Score = 279 bits (713), Expect = 3e-74 Identities = 144/423 (34%), Positives = 242/423 (57%), Gaps = 6/423 (1%) Frame = +1 Query: 163 GRLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEV 342 G +P GS+G P++GET F S F +R YG VFKT+++G P+++S DAEV Sbjct: 67 GMIPNGSLGWPVIGETLNFIACGYSSRPVTFMDKRKSLYGKVFKTNIIGTPIIISTDAEV 126 Query: 343 NRFIFQQEGKLFRSWYPDTANNIFGKESIASYDGSFHKYVRSFASRLFGLDSLRDVLLAE 522 N+ + Q G F YP + + G+ SI S +G K + + L+D + + Sbjct: 127 NKVVLQNHGNTFVPAYPKSITELLGENSILSINGPHQKRLHTLIGAFLRSPHLKDRITRD 186 Query: 523 MDCNVTDSLAAWAAEPAIEVKDAVANMVFDLTAKKLIGFSP-EKSRKLRKNFDAFFQGLV 699 ++ +V +LA+WA P + V+D + M F++ K L+ SP E L+ F+ F +GL+ Sbjct: 187 IEASVVLTLASWAQLPLVHVQDEIKKMTFEILVKVLMSTSPGEDMNILKLEFEEFIKGLI 246 Query: 700 SFPLYFPGTTFYRCIQGRKNVQKVLKDLLKERLGAPEKRHGDFLDEVVDELQSGRGVIDE 879 P+ FPGT Y+ ++ ++ + K++K +++ER A ++VVD L G ++ Sbjct: 247 CIPIKFPGTRLYKSLKAKERLIKMVKKVVEERQVAMTTTSP--ANDVVDVLLRDGGDSEK 304 Query: 880 K-----FAVDLMAALLFASFATVSSSLTIAMKFLSGHPNVVESLKEEHEAILKKREEGAK 1044 + F + ++ T+ +++T+A+KFLS +P + L EE+ +K+R+ Sbjct: 305 QSQPSDFVSGKIVEMMIPGEETMPTAMTLAVKFLSDNPVALAKLVEENME-MKRRKLELG 363 Query: 1045 SGITWEEYKSMTFTAQVTNEISRVSNVAPGIFRKTLTDVQVKGYTIPAGWLVMISPMAVH 1224 W +Y S++FT V NE R++N+ G++RK L DV++KGY IP GW V+ S ++VH Sbjct: 364 EEYKWTDYMSLSFTQNVINETLRMANIINGVWRKALKDVEIKGYLIPKGWCVLASFISVH 423 Query: 1225 LNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGIRLCVGAEFSRIQIALFLHTLVTK 1404 ++ +++++P F+PWRW + + F PFGGG RLC G E S+++I++FLH LVT+ Sbjct: 424 MDEDIYDNPYQFDPWRWDRINGSANSSICFTPFGGGQRLCPGLELSKLEISIFLHHLVTR 483 Query: 1405 YRW 1413 Y W Sbjct: 484 YSW 486
>Q940V4:C85A2_ARATH Cytochrome P450 85A2 - Arabidopsis thaliana (Mouse-ear cress)| Length = 465 Score = 273 bits (698), Expect = 2e-72 Identities = 153/474 (32%), Positives = 257/474 (54%), Gaps = 5/474 (1%) Frame = +1 Query: 85 LCGLAAVVAGWLAHCVYKWTNPACSTGRLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQ 264 + GL ++ L + +W S LPPG+MG P+ GET +F K P F K Sbjct: 7 ILGLLVIIV-CLCTALLRWNQMRYSKKGLPPGTMGWPIFGETTEFLKQGPD-----FMKN 60 Query: 265 RLKRYGPVFKTSLVGQPVVVSMDAEVNRFIFQQEGKLFRSWYPDTANNIFGKESIASYDG 444 + RYG FK+ ++G P +VSMDAE+NR+I E K + YP + +I G +IA+ G Sbjct: 61 QRLRYGSFFKSHILGCPTIVSMDAELNRYILMNESKGLVAGYPQSMLDILGTCNIAAVHG 120 Query: 445 SFHKYVRSFASRLFGLDSLRDVLLAEMDCNVTDSLAAWAAEPAIEVKDAVANMVFDLTAK 624 H+ +R L ++D LL ++D + + L W +++++ +M F L++ Sbjct: 121 PSHRLMRGSLLSLISPTMMKDHLLPKIDDFMRNYLCGWDDLETVDIQEKTKHMAF-LSSL 179 Query: 625 KLIGFSPEKSR--KLRKNFDAFFQGLVSFPLYFPGTTFYRCIQGRKNVQKVLKDLLKERL 798 I + +K + R F G +S P+ PGT + +Q R N+ ++L +L++ER Sbjct: 180 LQIAETLKKPEVEEYRTEFFKLVVGTLSVPIDIPGTNYRSGVQARNNIDRLLTELMQER- 238 Query: 799 GAPEKRHGDFLDEVVDEL---QSGRGVIDEKFAVDLMAALLFASFATVSSSLTIAMKFLS 969 K G+ +++ L + R ++ +K D + +L++ + TVS++ +A+K+L Sbjct: 239 ----KESGETFTDMLGYLMKKEDNRYLLTDKEIRDQVVTILYSGYETVSTTSMMALKYLH 294 Query: 970 GHPNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAPGIFRKT 1149 HP +E L+ EH AI +++ +T ++ KSM FT V E SR++ + G+ RKT Sbjct: 295 DHPKALEELRREHLAIRERKRPDEP--LTLDDIKSMKFTRAVIFETSRLATIVNGVLRKT 352 Query: 1150 LTDVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGG 1329 D+++ GY IP GW + + ++ + L+EDP+ FNPWRW ++S +S F+ FGG Sbjct: 353 THDLELNGYLIPKGWRIYVYTREINYDTSLYEDPMIFNPWRWMEKSLESK--SYFLLFGG 410 Query: 1330 GIRLCVGAEFSRIQIALFLHTLVTKYRWKEIKGGEVQRISEIVFPEGYHIQIIP 1491 G+RLC G E +++ FLH VTKYRW+E ++ + P+GYH++ P Sbjct: 411 GVRLCPGKELGISEVSSFLHYFVTKYRWEENGEDKLMVFPRVSAPKGYHLKCSP 464
>Q94IW5:C90D2_ORYSJ Cytochrome P450 90D2 - Oryza sativa subsp. japonica (Rice)| Length = 490 Score = 270 bits (690), Expect = 1e-71 Identities = 152/433 (35%), Positives = 241/433 (55%), Gaps = 12/433 (2%) Frame = +1 Query: 151 ACSTGRLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGP-VFKTSLVGQPVVVS 327 A + RLPPGS G P+VGET +F + S AF +R K +G VF++ L G VV+ Sbjct: 43 AAAAARLPPGSFGWPVVGETLEFVSCAYSPRPEAFVDKRRKLHGSAVFRSHLFGSATVVT 102 Query: 328 MDAEVNRFIFQQEGKLFRSWYPDTANNIFGKESIASYDGSFHKYVRSFASRLFGLDSLRD 507 DAEV+RF+ Q + + F WYP + + GK SI +G+ + V F L+ Sbjct: 103 ADAEVSRFVLQSDARAFVPWYPRSLTELMGKSSILLINGALQRRVHGLVGAFFKSSHLKS 162 Query: 508 VLLAEMDCNVTDSLAAWAAEPAIEVKDAVANMVFDLTAKKLIGFSP-EKSRKLRKNFDAF 684 L A+M ++ +L+++ + V+ ++VF++ + LIG E+ ++L++ F F Sbjct: 163 QLTADMRRRLSPALSSFPDSSLLHVQHLAKSVVFEILVRGLIGLEAGEEMQQLKQQFQEF 222 Query: 685 FQGLVSFPLYFPGTTFYRCIQGRKNVQKVLKDLLKE----RLGAPEKRH------GDFLD 834 GL+S P+ PGT YR +Q +K + ++++ +++E R A R GD D Sbjct: 223 IVGLMSLPIKLPGTRLYRSLQAKKKMARLIQRIIREKRARRAAASPPRDAIDVLIGDGSD 282 Query: 835 EVVDELQSGRGVIDEKFAVDLMAALLFASFATVSSSLTIAMKFLSGHPNVVESLKEEHEA 1014 E+ DEL S D M L+ + +V +T+A+KFLS P + L+EE+ Sbjct: 283 ELTDELIS-----------DNMIDLMIPAEDSVPVLITLAVKFLSECPLALHQLEEENIQ 331 Query: 1015 ILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAPGIFRKTLTDVQVKGYTIPAGW 1194 LK+R+ + W +Y S++FT V E R+ N+ GI RK + DV+VKG+ IP GW Sbjct: 332 -LKRRKTDMGETLQWTDYMSLSFTQHVITETLRLGNIIGGIMRKAVRDVEVKGHLIPKGW 390 Query: 1195 LVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGIRLCVGAEFSRIQI 1374 V + +VHL+ L+++P FNPWRW+++ + +F PFGGG RLC G + +R++ Sbjct: 391 CVFVYFRSVHLDDTLYDEPYKFNPWRWKEKDMSN---GSFTPFGGGQRLCPGLDLARLEA 447 Query: 1375 ALFLHTLVTKYRW 1413 ++FLH LVT +RW Sbjct: 448 SIFLHHLVTSFRW 460
>Q6F4F5:C724B_ORYSJ Cytochrome P450 724B1 - Oryza sativa subsp. japonica (Rice)| Length = 480 Score = 265 bits (676), Expect = 6e-70 Identities = 169/490 (34%), Positives = 251/490 (51%), Gaps = 10/490 (2%) Frame = +1 Query: 52 MEGYSQVAFASLCGLAAVVAGWLAHCVYKWTNPACSTGRLPPGSMGLPLVGETFQFFKPS 231 M G V A + LA ++ L+H + NP + P GS G PL+GET +F P Sbjct: 1 MVGGELVLAALVILLALLLTLVLSHFLPLLLNP-----KAPKGSFGWPLLGETLRFLSPH 55 Query: 232 PSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEVNRFIFQQEGKLFRSWYPDTANNI 411 S + +F + RYG VFK+ L P +VS D E+N FI Q E +LF+ YP + I Sbjct: 56 ASNTLGSFLEDHCSRYGRVFKSHLFCTPTIVSCDQELNHFILQNEERLFQCSYPRPIHGI 115 Query: 412 FGKESIASYDGSFHKYVRSFASRLFGLDSLRDVLLAEMDCNVTDSLAAWAAEP------- 570 GK S+ G HK +R+ A L L+ L +++ + +W + Sbjct: 116 LGKSSMLVVLGEDHKRLRNLALALVTSTKLKPSYLGDIEKIALHIVGSWHGKSKDKGMVN 175 Query: 571 AIEVKDAVANMVFDLTAKKLIGFSPEK--SRKLRKNFDAFFQGLVSFPLYFPGTTFYRCI 744 I + F + K+++G SPE+ + + ++F AF +GL+SFPLY PGT + + + Sbjct: 176 VIAFCEEARKFAFSVIVKQVLGLSPEEPVTAMILEDFLAFMKGLISFPLYIPGTPYAKAV 235 Query: 745 QGRKNVQKVLKDLLKERLGAPEKRHGDFLDEVVDELQSGRGVIDEKFAVDLMAALLFASF 924 Q R + +K +++ER A GDFL D L S + DE+ V + L + Sbjct: 236 QARARISSTVKGIIEERRNAGSSNKGDFL----DVLLSSNELSDEE-KVSFVLDSLLGGY 290 Query: 925 ATVSSSLTIAMKFLSGHPNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNE 1104 T S +++ + FL +E +K EHE I K+E+ ++ E+YK M +T V NE Sbjct: 291 ETTSLLISMVVYFLGQSAQDLELVKREHEGIRSKKEK--DEFLSSEDYKKMEYTQHVINE 348 Query: 1105 ISRVSNVAPGIFRKTLTDVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDE 1284 R N+ + RK L DV+ K Y IP+GW V+ AVHLNP L + F P RW+ Sbjct: 349 ALRCGNIVKFVHRKALKDVRYKEYLIPSGWKVLPVFSAVHLNPLLHGNAQQFQPCRWEGA 408 Query: 1285 SKKSTMLKNFMPFGGGIRLCVGAEFSRIQIALFLHTLVTKYRWKEIKGGEVQRISEIV-F 1461 S+ ++ K F PFGGG RLC G+E ++++ A FLH LV YRW+ I G ++ V F Sbjct: 409 SQGTS--KKFTPFGGGPRLCPGSELAKVEAAFFLHHLVLNYRWR-IDGDDIPMAYPYVEF 465 Query: 1462 PEGYHIQIIP 1491 G I+I P Sbjct: 466 QRGLPIEIEP 475
>Q09J78:ABAH2_ORYSI Abscisic acid 8'-hydroxylase 2 - Oryza sativa subsp. indica (Rice)| Length = 506 Score = 251 bits (642), Expect = 5e-66 Identities = 143/440 (32%), Positives = 229/440 (52%), Gaps = 5/440 (1%) Frame = +1 Query: 166 RLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEVN 345 RLPPGSMG P VGET Q + P++ F+ + KRYG +FKT+L+G P V+ E Sbjct: 50 RLPPGSMGWPYVGETLQLYSQDPNV----FFASKQKRYGEIFKTNLLGCPCVMLASPEAA 105 Query: 346 RFIFQQEGKLFRSWYPDTANNIFGKESIASYDGSFHKYVRSFASRLFGLDSLRDVLLAEM 525 RF+ + +LF+ YP + + G ++ + G +H +R DSLR L+ ++ Sbjct: 106 RFVLVSQARLFKPTYPPSKERMIGPSALFFHQGEYHLRLRRLVQAALAPDSLR-ALVPDV 164 Query: 526 DCNVTDSLAAWAAEPAIEVKDAVANMVFDLTAKKLIG--FSPEKSRKLRKNFDAFFQGLV 699 D V +LAAW+ A+ + FD+ + G +LR N+ +G Sbjct: 165 DAAVAATLAAWSGGHVASTFHAMKKLSFDVGVVTIFGGRLGRRHREELRTNYSVVERGYN 224 Query: 700 SFPLYFPGTTFYRCIQGRKNVQKVLKDLLKERL---GAPEKRHGDFLDEVVDELQSGRGV 870 FP FPGT +++ IQ RK ++ +L +++ ER G + G + D + Sbjct: 225 CFPNRFPGTLYHKAIQARKRLRAILSEIVAERRARGGGGDDLLGGLMRSRDDGTAGAVAL 284 Query: 871 IDEKFAVDLMAALLFASFATVSSSLTIAMKFLSGHPNVVESLKEEHEAILKKREEGAKSG 1050 + + D + +LFA+ T +S LT +K+L P ++E++K E AI E G K Sbjct: 285 LTDDQIADNVVGVLFAAQDTTASVLTWILKYLHDSPKLLEAVKAEQMAIYVANE-GGKRP 343 Query: 1051 ITWEEYKSMTFTAQVTNEISRVSNVAPGIFRKTLTDVQVKGYTIPAGWLVMISPMAVHLN 1230 +TW + +SMT T QV E R++++ FR+ + DV+ KG+ IP GW VM +H N Sbjct: 344 LTWTQTRSMTLTHQVILESLRMASIISFTFREAVADVEYKGFLIPKGWKVMPLFRNIHHN 403 Query: 1231 PELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGIRLCVGAEFSRIQIALFLHTLVTKYR 1410 P+ F+DP F+P R++ + ST F+PFG G+ C G E +++++ + +H LVT YR Sbjct: 404 PDYFQDPQKFDPSRFKVAPRPST----FLPFGSGVHACPGNELAKLEMLVLVHRLVTAYR 459 Query: 1411 WKEIKGGEVQRISEIVFPEG 1470 W+ + + S P G Sbjct: 460 WEIVGASDEVEYSPFPVPRG 479
>Q6ZDE3:ABAH2_ORYSJ Abscisic acid 8'-hydroxylase 2 - Oryza sativa subsp. japonica (Rice)| Length = 510 Score = 250 bits (638), Expect = 2e-65 Identities = 143/444 (32%), Positives = 229/444 (51%), Gaps = 9/444 (2%) Frame = +1 Query: 166 RLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEVN 345 RLPPGSMG P VGET Q + P++ F+ + KRYG +FKT+L+G P V+ E Sbjct: 50 RLPPGSMGWPYVGETLQLYSQDPNV----FFASKQKRYGEIFKTNLLGCPCVMLASPEAA 105 Query: 346 RFIFQQEGKLFRSWYPDTANNIFGKESIASYDGSFHKYVRSFASRLFGLDSLRDVLLAEM 525 RF+ + +LF+ YP + + G ++ + G +H +R DSLR L+ ++ Sbjct: 106 RFVLVSQARLFKPTYPPSKERMIGPSALFFHQGEYHLRLRRLVQAALAPDSLR-ALVPDV 164 Query: 526 DCNVTDSLAAWAAEPAIEVKDAVANMVFDLTAKKLIG--FSPEKSRKLRKNFDAFFQGLV 699 D V +LAAW+ A+ + FD+ + G +LR N+ +G Sbjct: 165 DAAVAATLAAWSGGHVASTFHAMKKLSFDVGVVTIFGGRLGRRHREELRTNYSVVERGYN 224 Query: 700 SFPLYFPGTTFYRCIQGRKNVQKVLKDLLKERL-------GAPEKRHGDFLDEVVDELQS 858 FP FPGT +++ IQ RK ++ +L +++ ER G + G + D Sbjct: 225 CFPNRFPGTLYHKAIQARKRLRAILSEIVAERRARGGGGGGGGDDLLGGLMRSRDDGTAG 284 Query: 859 GRGVIDEKFAVDLMAALLFASFATVSSSLTIAMKFLSGHPNVVESLKEEHEAILKKREEG 1038 ++ + D + +LFA+ T +S LT +K+L P ++E++K E AI E G Sbjct: 285 AVALLTDDQIADNVVGVLFAAQDTTASVLTWILKYLHDSPKLLEAVKAEQMAIYVANE-G 343 Query: 1039 AKSGITWEEYKSMTFTAQVTNEISRVSNVAPGIFRKTLTDVQVKGYTIPAGWLVMISPMA 1218 K +TW + +SMT T QV E R++++ FR+ + DV+ KG+ IP GW VM Sbjct: 344 GKRPLTWTQTRSMTLTHQVILESLRMASIISFTFREAVADVEYKGFLIPKGWKVMPLFRN 403 Query: 1219 VHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGIRLCVGAEFSRIQIALFLHTLV 1398 +H NP+ F+DP F+P R++ + ST F+PFG G+ C G E +++++ + +H LV Sbjct: 404 IHHNPDYFQDPQKFDPSRFKVAPRPST----FLPFGSGVHACPGNELAKLEMLVLVHRLV 459 Query: 1399 TKYRWKEIKGGEVQRISEIVFPEG 1470 T YRW+ + + S P G Sbjct: 460 TAYRWEIVGASDEVEYSPFPVPRG 483
>Q9LJK2:ABAH4_ARATH Abscisic acid 8'-hydroxylase 4 - Arabidopsis thaliana (Mouse-ear| cress) Length = 468 Score = 248 bits (634), Expect = 4e-65 Identities = 139/430 (32%), Positives = 240/430 (55%), Gaps = 4/430 (0%) Frame = +1 Query: 157 STGRLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDA 336 S G+LPPGSMG P +GET Q + +P++ F+ + KRYG +FKT ++G P V+ Sbjct: 30 SRGKLPPGSMGWPYLGETLQLYSQNPNV----FFTSKQKRYGEIFKTRILGYPCVMLASP 85 Query: 337 EVNRFIFQQEGKLFRSWYPDTANNIFGKESIASYDGSFHKYVRSFASRLFGLDSLRDVLL 516 E RF+ +F+ YP + + G ++ + G +H ++R F +++R L+ Sbjct: 86 EAARFVLVTHAHMFKPTYPRSKEKLIGPSALFFHQGDYHSHIRKLVQSSFYPETIRK-LI 144 Query: 517 AEMDCNVTDSLAAWAAEPAIEVKDAVANMVFDLTAKKLIGFSPEKSRKLRK-NFDAFFQG 693 +++ SL +WA P + + FD+ + G +++ K N++ +G Sbjct: 145 PDIEHIALSSLQSWANMPIVSTYQEMKKFAFDVGILAIFGHLESSYKEILKHNYNIVDKG 204 Query: 694 LVSFPLYFPGTTFYRCIQGRKNVQKVLKDLLKERLGAPEKR--HGDFLDEVVD-ELQSGR 864 SFP+ PGT++++ + RK ++ ++ +++ ER EKR DFL +++ + + GR Sbjct: 205 YNSFPMSLPGTSYHKALMARKQLKTIVSEIICERR---EKRALQTDFLGHLLNFKNEKGR 261 Query: 865 GVIDEKFAVDLMAALLFASFATVSSSLTIAMKFLSGHPNVVESLKEEHEAILKKREEGAK 1044 + E+ A D + +LFA+ T +S LT +K+L ++E++K E +AI ++ K Sbjct: 262 VLTQEQIA-DNIIGVLFAAQDTTASCLTWILKYLHDDQKLLEAVKAEQKAIYEENSR-EK 319 Query: 1045 SGITWEEYKSMTFTAQVTNEISRVSNVAPGIFRKTLTDVQVKGYTIPAGWLVMISPMAVH 1224 +TW + ++M T +V E R++++ FR+ + DV+ KGY IP GW VM +H Sbjct: 320 KPLTWRQTRNMPLTHKVIVESLRMASIISFTFREAVVDVEYKGYLIPKGWKVMPLFRNIH 379 Query: 1225 LNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGIRLCVGAEFSRIQIALFLHTLVTK 1404 NP+ F +P F+P R++ K +T FMPFG G+ C G E +++QI +FLH LV+ Sbjct: 380 HNPKYFSNPEVFDPSRFEVNPKPNT----FMPFGSGVHACPGNELAKLQILIFLHHLVSN 435 Query: 1405 YRWKEIKGGE 1434 +RW E+KGGE Sbjct: 436 FRW-EVKGGE 444
>Q0J185:ABAH3_ORYSJ Abscisic acid 8'-hydroxylase 3 - Oryza sativa subsp. japonica (Rice)| Length = 500 Score = 246 bits (627), Expect = 3e-64 Identities = 143/438 (32%), Positives = 237/438 (54%), Gaps = 4/438 (0%) Frame = +1 Query: 166 RLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEVN 345 RLPPGSMG P +GET Q + P++ F+ + KRYG +FKT ++G P V+ E Sbjct: 43 RLPPGSMGWPYIGETLQLYSQDPNV----FFASKQKRYGEIFKTHILGCPCVMLASPEAA 98 Query: 346 RFIFQQEGKLFRSWYPDTANNIFGKESIASYDGSFHKYVRSFASRLFGLDSLRDVLLAEM 525 RF+ + LF+ YP + + G ++ + G +H +R G D+LR L+ ++ Sbjct: 99 RFVLVTQAHLFKPTYPRSKERMIGPSALFFHQGDYHLRLRKLVQGPLGPDALR-ALVPDV 157 Query: 526 DCNVTDSLAAWAAEPAIEVKDAVANMVFDLTAKKLIGFSPEKSRK--LRKNFDAFFQGLV 699 + V +LA+W + A+ + FD+ + G ++ RK LR+N+ +G Sbjct: 158 EAAVRSTLASWDGNVS-STFHAMKRLSFDVGIVTIFGGRLDERRKAELRQNYAIVEKGYN 216 Query: 700 SFPLYFPGTTFYRCIQGRKNVQKVLKDLLKERLGAPEKRHGDFLDEVVDELQSGRGVI-- 873 SFP FPGT +Y+ IQ R+ + VL D+++ER E D L ++ G + Sbjct: 217 SFPNSFPGTLYYKAIQARRRLHGVLSDIMRERRARGEPG-SDLLGCLMQSRAGDDGALLT 275 Query: 874 DEKFAVDLMAALLFASFATVSSSLTIAMKFLSGHPNVVESLKEEHEAILKKREEGAKSGI 1053 DE+ A D + +LFA+ T +S LT +K+L HP ++E+++ E AI + +G + + Sbjct: 276 DEQVA-DNIIGVLFAAQDTTASVLTWIVKYLHDHPKLLEAVRAEQAAI-RAANDGGRLPL 333 Query: 1054 TWEEYKSMTFTAQVTNEISRVSNVAPGIFRKTLTDVQVKGYTIPAGWLVMISPMAVHLNP 1233 TW + +SM T +V E R++++ FR+ + DV+ KG+ IP GW VM +H NP Sbjct: 334 TWAQTRSMALTHKVILESLRMASIISFTFREAVADVEYKGFLIPKGWKVMPLFRNIHHNP 393 Query: 1234 ELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGIRLCVGAEFSRIQIALFLHTLVTKYRW 1413 + F+DP F+P R++ + +T FMPFG G+ C G E +++++ + +H LVT YRW Sbjct: 394 DYFQDPQKFDPSRFKVSPRPNT----FMPFGNGVHACPGNELAKLEMLVLIHHLVTGYRW 449 Query: 1414 KEIKGGEVQRISEIVFPE 1467 + + + S P+ Sbjct: 450 EIVGSSDEVEYSPFPVPK 467
>A2Z212:ABAH3_ORYSI Abscisic acid 8'-hydroxylase 3 - Oryza sativa subsp. indica (Rice)| Length = 500 Score = 244 bits (623), Expect = 8e-64 Identities = 143/438 (32%), Positives = 236/438 (53%), Gaps = 4/438 (0%) Frame = +1 Query: 166 RLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEVN 345 RLPPGSMG P +GET Q + P++ F+ + KRYG +FKT ++G P V+ E Sbjct: 43 RLPPGSMGWPYIGETLQLYSQDPNV----FFASKQKRYGEIFKTHILGCPCVMLASPEAA 98 Query: 346 RFIFQQEGKLFRSWYPDTANNIFGKESIASYDGSFHKYVRSFASRLFGLDSLRDVLLAEM 525 RF+ + LF+ YP + + G ++ G +H +R G D+LR L+ ++ Sbjct: 99 RFVLVTQAHLFKPTYPRSKERMIGPSALFFNQGDYHLRLRKLVQGPLGPDALR-ALVPDV 157 Query: 526 DCNVTDSLAAWAAEPAIEVKDAVANMVFDLTAKKLIGFSPEKSRK--LRKNFDAFFQGLV 699 + V +LA+W + A+ + FD+ + G ++ RK LR+N+ +G Sbjct: 158 EAAVRSTLASWDGNVS-STFHAMKRLSFDVGIVTIFGGRLDERRKAELRQNYAIVEKGYN 216 Query: 700 SFPLYFPGTTFYRCIQGRKNVQKVLKDLLKERLGAPEKRHGDFLDEVVDELQSGRGVI-- 873 SFP FPGT +Y+ IQ R+ + VL D+++ER E D L ++ G + Sbjct: 217 SFPNSFPGTLYYKAIQARRRLHGVLSDIMRERRARGEPG-SDLLGCLMQSRAGDDGALLT 275 Query: 874 DEKFAVDLMAALLFASFATVSSSLTIAMKFLSGHPNVVESLKEEHEAILKKREEGAKSGI 1053 DE+ A D + +LFA+ T +S LT +K+L HP ++E+++ E AI + +G + + Sbjct: 276 DEQVA-DNIIGVLFAAQDTTASVLTWIVKYLHDHPKLLEAVRAEQAAI-RAANDGGRLPL 333 Query: 1054 TWEEYKSMTFTAQVTNEISRVSNVAPGIFRKTLTDVQVKGYTIPAGWLVMISPMAVHLNP 1233 TW + +SM T +V E R++++ FR+ + DV+ KG+ IP GW VM +H NP Sbjct: 334 TWAQTRSMALTHKVILESLRMASIISFTFREAVADVEYKGFLIPKGWKVMPLFRNIHHNP 393 Query: 1234 ELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGIRLCVGAEFSRIQIALFLHTLVTKYRW 1413 + F+DP F+P R++ + +T FMPFG G+ C G E +++++ + +H LVT YRW Sbjct: 394 DYFQDPQKFDPSRFKVSPRPNT----FMPFGNGVHACPGNELAKLEMLVLIHHLVTGYRW 449 Query: 1414 KEIKGGEVQRISEIVFPE 1467 + + + S P+ Sbjct: 450 EIVGSSDEVEYSPFPVPK 467
>Q9FH76:ABAH3_ARATH Abscisic acid 8'-hydroxylase 3 - Arabidopsis thaliana (Mouse-ear| cress) Length = 463 Score = 235 bits (599), Expect = 5e-61 Identities = 134/416 (32%), Positives = 230/416 (55%), Gaps = 1/416 (0%) Frame = +1 Query: 169 LPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEVNR 348 LPPG+MG P VGETFQ + P++ F+ + +RYG VFKT ++G P V+ E + Sbjct: 36 LPPGTMGYPYVGETFQLYSQDPNV----FFAAKQRRYGSVFKTHVLGCPCVMISSPEAAK 91 Query: 349 FIFQQEGKLFRSWYPDTANNIFGKESIASYDGSFHKYVRSFASRLFGLDSLRDVLLAEMD 528 F+ + LF+ +P + + GK++I + G +H +R R F D++R+ ++ ++ Sbjct: 92 FVLVTKSHLFKPTFPASKERMLGKQAIFFHQGDYHSKLRKLVLRAFMPDAIRN-MVPHIE 150 Query: 529 CNVTDSLAAWAAEPAIEVKDAVANMVFDLTAKKLIGFSPEKSRK-LRKNFDAFFQGLVSF 705 +SL +W + + F++ ++G R+ L++ + +G S Sbjct: 151 SIAQESLNSWDGTQ-LNTYQEMKTYTFNVALISILGKDEVYYREDLKRCYYILEKGYNSM 209 Query: 706 PLYFPGTTFYRCIQGRKNVQKVLKDLLKERLGAPEKRHGDFLDEVVDELQSGRGVIDEKF 885 P+ PGT F++ ++ RK + ++L ++L +R P H D L +++ G+ DE+ Sbjct: 210 PINLPGTLFHKAMKARKELAQILANILSKRRQNPSS-HTDLLGSFMEDKA---GLTDEQI 265 Query: 886 AVDLMAALLFASFATVSSSLTIAMKFLSGHPNVVESLKEEHEAILKKREEGAKSGITWEE 1065 A D + ++FA+ T +S LT +K+L+ +P V+E++ EE AI K ++EG +TWE+ Sbjct: 266 A-DNIIGVIFAARDTTASVLTWILKYLADNPTVLEAVTEEQMAIRKDKKEG--ESLTWED 322 Query: 1066 YKSMTFTAQVTNEISRVSNVAPGIFRKTLTDVQVKGYTIPAGWLVMISPMAVHLNPELFE 1245 K M T +V E R + + FR+ + DV+ +GY IP GW V+ +H N ++F Sbjct: 323 TKKMPLTYRVIQETLRAATILSFTFREAVEDVEYEGYLIPKGWKVLPLFRNIHHNADIFS 382 Query: 1246 DPLTFNPWRWQDESKKSTMLKNFMPFGGGIRLCVGAEFSRIQIALFLHTLVTKYRW 1413 DP F+P R++ K +T FMPFG GI C G E ++++I++ +H L TKYRW Sbjct: 383 DPGKFDPSRFEVAPKPNT----FMPFGSGIHSCPGNELAKLEISVLIHHLTTKYRW 434
>Q949P1:ABAH1_ARATH Abscisic acid 8'-hydroxylase 1 - Arabidopsis thaliana (Mouse-ear| cress) Length = 467 Score = 229 bits (583), Expect = 4e-59 Identities = 127/434 (29%), Positives = 235/434 (54%), Gaps = 1/434 (0%) Frame = +1 Query: 169 LPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEVNR 348 LPPG+MG P VGETFQ + P++ F++ + KRYG VFKT ++G P V+ E + Sbjct: 36 LPPGTMGWPYVGETFQLYSQDPNV----FFQSKQKRYGSVFKTHVLGCPCVMISSPEAAK 91 Query: 349 FIFQQEGKLFRSWYPDTANNIFGKESIASYDGSFHKYVRSFASRLFGLDSLRDVLLAEMD 528 F+ + LF+ +P + + GK++I + G +H +R R F +S+R+ ++ +++ Sbjct: 92 FVLVTKSHLFKPTFPASKERMLGKQAIFFHQGDYHAKLRKLVLRAFMPESIRN-MVPDIE 150 Query: 529 CNVTDSLAAWAAEPAIEVKDAVANMVFDLTAKKLIGFSPEKSRK-LRKNFDAFFQGLVSF 705 DSL +W I + F++ + G R+ L++ + +G S Sbjct: 151 SIAQDSLRSWEG-TMINTYQEMKTYTFNVALLSIFGKDEVLYREDLKRCYYILEKGYNSM 209 Query: 706 PLYFPGTTFYRCIQGRKNVQKVLKDLLKERLGAPEKRHGDFLDEVVDELQSGRGVIDEKF 885 P+ PGT F++ ++ RK + ++L +L ER +++G ++++ + + ++ Sbjct: 210 PVNLPGTLFHKSMKARKELSQILARILSER-----RQNGSSHNDLLGSFMGDKEELTDEQ 264 Query: 886 AVDLMAALLFASFATVSSSLTIAMKFLSGHPNVVESLKEEHEAILKKREEGAKSGITWEE 1065 D + ++FA+ T +S ++ +K+L+ +PNV+E++ EE AI K +EEG +TW + Sbjct: 265 IADNIIGVIFAARDTTASVMSWILKYLAENPNVLEAVTEEQMAIRKDKEEG--ESLTWGD 322 Query: 1066 YKSMTFTAQVTNEISRVSNVAPGIFRKTLTDVQVKGYTIPAGWLVMISPMAVHLNPELFE 1245 K M T++V E RV+++ FR+ + DV+ +GY IP GW V+ +H + ++F Sbjct: 323 TKKMPLTSRVIQETLRVASILSFTFREAVEDVEYEGYLIPKGWKVLPLFRNIHHSADIFS 382 Query: 1246 DPLTFNPWRWQDESKKSTMLKNFMPFGGGIRLCVGAEFSRIQIALFLHTLVTKYRWKEIK 1425 +P F+P R++ K +T FMPFG G C G E +++++++ +H L TKY W + Sbjct: 383 NPGKFDPSRFEVAPKPNT----FMPFGNGTHSCPGNELAKLEMSIMIHHLTTKYSWSIVG 438 Query: 1426 GGEVQRISEIVFPE 1467 + + P+ Sbjct: 439 ASDGIQYGPFALPQ 452
>Q9AXM6:T10H_TAXCU Taxane 10-beta-hydroxylase - Taxus cuspidata (Japanese yew)| Length = 497 Score = 228 bits (580), Expect = 8e-59 Identities = 139/457 (30%), Positives = 230/457 (50%), Gaps = 11/457 (2%) Frame = +1 Query: 157 STGRLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDA 336 S+ +LPPG +G PL+GET Q + S F+ RLK++GPV+ TSL+G P VV Sbjct: 46 SSVKLPPGKLGFPLIGETIQLLRTLRSETPQKFFDDRLKKFGPVYMTSLIGHPTVVLCGP 105 Query: 337 EVNRFIFQQEGKLFRSWYPDTANNIFGKESIASYDGSFHKYVRSFASRLFGLDSLRDVLL 516 N+ + E KL P + + G++SI + G H+ +R+ +R G +L++ L Sbjct: 106 AGNKLVLSNEDKLVEMEGPKSFMKLIGEDSIVAKRGEDHRILRTALARFLGAQALQN-YL 164 Query: 517 AEMDCNVTDSL-AAWAAEPAIEVKDAVANMVFDLTAKKLIGFSP-EKSRKLRKNFDAFFQ 690 M + W + ++V V ++F + + + + ++L + Sbjct: 165 GRMSSEIGHHFNEKWKGKDEVKVLPLVRGLIFSIASTLFFDVNDGHQQKQLHHLLETILV 224 Query: 691 GLVSFPLYFPGTTFYRCIQGRKNVQKVLKDLLKERLGAPEKRHG------DFLDEVVDEL 852 G +S PL FPGT + + +Q R + ++L L+K R + R G D L ++ Sbjct: 225 GSLSVPLDFPGTRYRKGLQARLKLDEILSSLIKRR--RRDLRSGIASDDQDLLSVLLTFR 282 Query: 853 QSGRGVIDEKFAVDLMAALLFASFATVSSSLTIAMKFLSGHPNVVESLKEEHEAILKKRE 1032 + ++ +D +A+ AS+ T + + + K L +P E + +E I+ ++ Sbjct: 283 DEKGNSLTDQGILDNFSAMFHASYDTTVAPMALIFKLLYSNPEYHEKVFQEQLEIIGNKK 342 Query: 1033 EGAKSGITWEEYKSMTFTAQVTNEISRVSNVAPGIFRKTLTDVQVKGYTIPAGWLVMISP 1212 EG + I+W++ KSM +T Q E R+ GIFRK +TD+ GYTIP GW V+ SP Sbjct: 343 EGEE--ISWKDLKSMKYTWQAVQESLRMYPPVFGIFRKAITDIHYDGYTIPKGWRVLCSP 400 Query: 1213 MAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGIRLCVGAEFSRIQIALFLHT 1392 HL E F +P F P R++DE + T ++PFGGG+R C G EFS+I+I LF+H Sbjct: 401 YTTHLREEYFPEPEEFRPSRFEDEGRHVTPY-TYVPFGGGLRTCPGWEFSKIEILLFVHH 459 Query: 1393 LVTKYRWKEIKGGEVQRISEIVFP---EGYHIQIIPR 1494 V + + +S+ + P G+ I++ PR Sbjct: 460 FVKNFSSYIPVDPNEKVLSDPLPPLPANGFSIKLFPR 496
>Q8W4T9:T13H_TAXCU Taxane 13-alpha-hydroxylase - Taxus cuspidata (Japanese yew)| Length = 485 Score = 220 bits (560), Expect = 2e-56 Identities = 127/423 (30%), Positives = 216/423 (51%), Gaps = 6/423 (1%) Frame = +1 Query: 157 STGRLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDA 336 S+ +LPPG++G PLVGET QF + S F ++R+ ++G VFKTS++G P VV Sbjct: 34 SSVKLPPGNLGFPLVGETLQFVRSLGSSTPQQFIEERMSKFGDVFKTSIIGHPTVVLCGP 93 Query: 337 EVNRFIFQQEGKLFRSWYPDTANNIFGKESIASYDGSFHKYVRSFASRLFGLDSLRDVLL 516 NR + E KL + +P + + G++ + G H+ VR+ +R G +L++ Sbjct: 94 AGNRLVLSNENKLVQMSWPSSMMKLIGEDCLGGKTGEQHRIVRAALTRFLGPQALQN-HF 152 Query: 517 AEMDCNVTDSL-AAWAAEPAIEVKDAVANMVFDLTAKKLIGFSPEK-SRKLRKNFDAFFQ 690 A+M + + W + V V ++VF + ++ G + E +L + Sbjct: 153 AKMSSGIQRHINEKWKGKDEATVLPLVKDLVFSVASRLFFGITEEHLQEQLHNLLEVILV 212 Query: 691 GLVSFPLYFPGTTFYRCIQGRKNVQKVLKDLLKER----LGAPEKRHGDFLDEVVDELQS 858 G S PL PG ++++ IQ R + ++ L+++R + D L ++ Sbjct: 213 GSFSVPLNIPGFSYHKAIQARATLADIMTHLIEKRRNELRAGTASENQDLLSVLLTFTDE 272 Query: 859 GRGVIDEKFAVDLMAALLFASFATVSSSLTIAMKFLSGHPNVVESLKEEHEAILKKREEG 1038 + +K +D + LL S+ + +S LT+ +K L+ HP E + +E IL + EG Sbjct: 273 RGNSLADKEILDNFSMLLHGSYDSTNSPLTMLIKVLASHPESYEKVAQEQFGILSTKMEG 332 Query: 1039 AKSGITWEEYKSMTFTAQVTNEISRVSNVAPGIFRKTLTDVQVKGYTIPAGWLVMISPMA 1218 + I W++ K M ++ QV E R+ G FRK +TD+ GYTIP GW ++ + + Sbjct: 333 EE--IAWKDLKEMKYSWQVVQETLRMYPPIFGTFRKAITDIHYNGYTIPKGWKLLWTTYS 390 Query: 1219 VHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGIRLCVGAEFSRIQIALFLHTLV 1398 E F+D F P R+++E K T ++PFGGG+R+C G EF++++ LFLH V Sbjct: 391 TQTKEEYFKDADQFKPSRFEEEGKHVTPY-TYLPFGGGMRVCPGWEFAKMETLLFLHHFV 449 Query: 1399 TKY 1407 + Sbjct: 450 KAF 452
>Q05JG2:ABAH1_ORYSJ Abscisic acid 8'-hydroxylase 1 - Oryza sativa subsp. japonica (Rice)| Length = 471 Score = 216 bits (551), Expect = 2e-55 Identities = 131/422 (31%), Positives = 220/422 (52%), Gaps = 3/422 (0%) Frame = +1 Query: 169 LPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEVNR 348 LPPGSMG P VGETFQ + S + F+ ++ +YGP+FKT ++G P V+ E R Sbjct: 39 LPPGSMGWPYVGETFQLYS---SKNPNVFFNKKRNKYGPIFKTHILGCPCVMVSSPEAAR 95 Query: 349 FIFQQEGKLFRSWYPDTANNIFGKESIASYDGSFHKYVRSFASRLFGLDSLRDVLLAEMD 528 F+ + LF+ +P + + G ++I G +H ++R SR F +S+R + A ++ Sbjct: 96 FVLVTQAHLFKPTFPASKERMLGPQAIFFQQGDYHAHLRRIVSRAFSPESIRASVPA-IE 154 Query: 529 CNVTDSLAAWAAEPAIEVKDAVANMVFDLTAKKLIGFSPEKSR---KLRKNFDAFFQGLV 699 SL +W + ++ + L L F E+ R +L++ + +G Sbjct: 155 AIALRSLHSWDGQFVNTFQEM---KTYALNVALLSIFGEEEMRYIEELKQCYLTLEKGYN 211 Query: 700 SFPLYFPGTTFYRCIQGRKNVQKVLKDLLKERLGAPEKRHGDFLDEVVDELQSGRGVIDE 879 S P+ PGT F++ ++ RK + ++ ++ R +R D L VD GR + + Sbjct: 212 SMPVNLPGTLFHKAMKARKRLGAIVAHIISAR--RERQRGNDLLGSFVD----GREALTD 265 Query: 880 KFAVDLMAALLFASFATVSSSLTIAMKFLSGHPNVVESLKEEHEAILKKREEGAKSGITW 1059 D + ++FA+ T +S LT +KFL HP V++++ EE I K++E + ++W Sbjct: 266 AQIADNVIGVIFAARDTTASVLTWMVKFLGDHPAVLKAVTEEQLQIAKEKEASGEP-LSW 324 Query: 1060 EEYKSMTFTAQVTNEISRVSNVAPGIFRKTLTDVQVKGYTIPAGWLVMISPMAVHLNPEL 1239 + + M T++V E RV+++ FR+ + DV+ +GY IP GW V+ +H NP+ Sbjct: 325 ADTRRMKMTSRVIQETMRVASILSFTFREAVEDVEYQGYLIPKGWKVLPLFRNIHHNPDH 384 Query: 1240 FEDPLTFNPWRWQDESKKSTMLKNFMPFGGGIRLCVGAEFSRIQIALFLHTLVTKYRWKE 1419 F P F+P R++ K +T FMPFG G C G E +++++ + H L TKYRW Sbjct: 385 FPCPEKFDPSRFEVAPKPNT----FMPFGNGTHSCPGNELAKLEMLVLFHHLATKYRWST 440 Query: 1420 IK 1425 K Sbjct: 441 SK 442
>Q09J79:ABAH1_ORYSI Abscisic acid 8'-hydroxylase 1 - Oryza sativa subsp. indica (Rice)| Length = 471 Score = 216 bits (551), Expect = 2e-55 Identities = 131/422 (31%), Positives = 220/422 (52%), Gaps = 3/422 (0%) Frame = +1 Query: 169 LPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEVNR 348 LPPGSMG P VGETFQ + S + F+ ++ +YGP+FKT ++G P V+ E R Sbjct: 39 LPPGSMGWPYVGETFQLYS---SKNPNVFFNKKRNKYGPIFKTHILGCPCVMVSSPEAAR 95 Query: 349 FIFQQEGKLFRSWYPDTANNIFGKESIASYDGSFHKYVRSFASRLFGLDSLRDVLLAEMD 528 F+ + LF+ +P + + G ++I G +H ++R SR F +S+R + A ++ Sbjct: 96 FVLVTQAHLFKPTFPASKERMLGPQAIFFQQGDYHAHLRRIVSRAFSPESIRASVPA-IE 154 Query: 529 CNVTDSLAAWAAEPAIEVKDAVANMVFDLTAKKLIGFSPEKSR---KLRKNFDAFFQGLV 699 SL +W + ++ + L L F E+ R +L++ + +G Sbjct: 155 AIALRSLHSWDGQFVNTFQEM---KTYALNVALLSIFGEEEMRYIEELKQCYLTLEKGYN 211 Query: 700 SFPLYFPGTTFYRCIQGRKNVQKVLKDLLKERLGAPEKRHGDFLDEVVDELQSGRGVIDE 879 S P+ PGT F++ ++ RK + ++ ++ R +R D L VD GR + + Sbjct: 212 SMPVNLPGTLFHKAMKARKRLGAIVAHIISAR--RERQRGNDLLGSFVD----GREALTD 265 Query: 880 KFAVDLMAALLFASFATVSSSLTIAMKFLSGHPNVVESLKEEHEAILKKREEGAKSGITW 1059 D + ++FA+ T +S LT +KFL HP V++++ EE I K++E + ++W Sbjct: 266 AQIADNVIGVIFAARDTTASVLTWMVKFLGDHPAVLKAVTEEQLQIAKEKEASGEP-LSW 324 Query: 1060 EEYKSMTFTAQVTNEISRVSNVAPGIFRKTLTDVQVKGYTIPAGWLVMISPMAVHLNPEL 1239 + + M T++V E RV+++ FR+ + DV+ +GY IP GW V+ +H NP+ Sbjct: 325 ADTRRMKMTSRVIQETMRVASILSFTFREAVEDVEYQGYLIPKGWKVLPLFRNIHHNPDH 384 Query: 1240 FEDPLTFNPWRWQDESKKSTMLKNFMPFGGGIRLCVGAEFSRIQIALFLHTLVTKYRWKE 1419 F P F+P R++ K +T FMPFG G C G E +++++ + H L TKYRW Sbjct: 385 FPCPEKFDPSRFEVAPKPNT----FMPFGNGTHSCPGNELAKLEMLVLFHHLATKYRWST 440 Query: 1420 IK 1425 K Sbjct: 441 SK 442
>O81077:ABAH2_ARATH Abscisic acid 8'-hydroxylase 2 - Arabidopsis thaliana (Mouse-ear| cress) Length = 482 Score = 215 bits (548), Expect = 4e-55 Identities = 126/447 (28%), Positives = 231/447 (51%), Gaps = 5/447 (1%) Frame = +1 Query: 166 RLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEVN 345 RLPPGSMGLP +GET + + +P+ +F+ R +YG +FKT ++G P V+ E Sbjct: 48 RLPPGSMGLPYIGETLRLYTENPN----SFFATRQNKYGDIFKTHILGCPCVMISSPEAA 103 Query: 346 RFIFQQEGKLFRSWYPDTANNIFGKESIASYDGSFHKYVRSFASRLFGLDSLRDVLLAEM 525 R + + LF+ YP + + G E++ + G +H ++ F +LR + + + Sbjct: 104 RMVLVSKAHLFKPTYPPSKERMIGPEALFFHQGPYHSTLKRLVQSSFMPSALRPTV-SHI 162 Query: 526 DCNVTDSLAAWAAEPAIEVKDAVANMVFDLTAKKLIGFSPEKSR--KLRKNFDAFFQGLV 699 + V +L++W ++ +I + + FD+ G E + ++ + +G Sbjct: 163 ELLVLQTLSSWTSQKSINTLEYMKRYAFDVAIMSAFGDKEEPTTIDVIKLLYQRLERGYN 222 Query: 700 SFPLYFPGTTFYRCIQGRKNVQKVLKDLLKERLGAPEKRHGDFLDEVVDELQSGRGVIDE 879 S PL PGT F++ ++ R + + L+ ++++R + G L ++ R + + Sbjct: 223 SMPLDLPGTLFHKSMKARIELSEELRKVIEKRR-ENGREEGGLLGVLLGAKDQKRNGLSD 281 Query: 880 KFAVDLMAALLFASFATVSSSLTIAMKFLSGHPNVVESLKEEHEAILKKREEGAKSGITW 1059 D + ++FA+ T +S LT +K+L HPN+++ + E +I +K ++ + I+W Sbjct: 282 SQIADNIIGVIFAATDTTASVLTWLLKYLHDHPNLLQEVSREQFSIRQKIKKENRR-ISW 340 Query: 1060 EEYKSMTFTAQVTNEISRVSNVAPGIFRKTLTDVQVKGYTIPAGWLVMISPMAVHLNPEL 1239 E+ + M T +V E R ++V FR+ + DV+ GY IP GW V+ +H + E Sbjct: 341 EDTRKMPLTTRVIQETLRAASVLSFTFREAVQDVEYDGYLIPKGWKVLPLFRRIHHSSEF 400 Query: 1240 FEDPLTFNPWRWQDESKKSTMLKNFMPFGGGIRLCVGAEFSRIQIALFLHTLVTKYRWKE 1419 F DP F+P R++ K T +MPFG G+ C G+E +++++ + LH L T +RW+ Sbjct: 401 FPDPEKFDPSRFEVAPKPYT----YMPFGNGVHSCPGSELAKLEMLILLHHLTTSFRWEV 456 Query: 1420 IKGGEVQRISEIVFP---EGYHIQIIP 1491 I G+ + I FP +G I++ P Sbjct: 457 I--GDEEGIQYGPFPVPKKGLPIRVTP 481
>Q9PUB4:CP26A_CHICK Cytochrome P450 26A1 - Gallus gallus (Chicken)| Length = 492 Score = 192 bits (487), Expect = 5e-48 Identities = 134/484 (27%), Positives = 233/484 (48%), Gaps = 15/484 (3%) Frame = +1 Query: 58 GYSQVAFASLCGLAAVVAGWLAHCVYKWTNPACSTGR-------LPPGSMGLPLVGETFQ 216 G+S + ++LC + +LA V W + C++GR LPPG+MGLP GET Q Sbjct: 2 GFSALVASALCTFLLPLLLFLA-AVRLW-DLYCASGRDPSCPLPLPPGTMGLPFFGETLQ 59 Query: 217 FFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEVNRFIFQQEGKLFRSWYPD 396 L F + + ++YG ++KT L G+P V M AE R I E +L +P Sbjct: 60 MV-----LQRRKFLQMKRRKYGFIYKTHLFGRPTVRVMGAENVRHILLGEHRLVSVQWPA 114 Query: 397 TANNIFGKESIASYDGSFHKYVRSFASRLFGLDSLRDVLLAEMDCNVTDSLAAW-AAEPA 573 + I G +++ HK+ + + F D+L+ + + V+ LA W A P Sbjct: 115 SVRTILGSGCLSNLHNGQHKHRKKVIMQAFSRDALQHYVPVIQE-EVSACLAQWLGAGPC 173 Query: 574 IEVKDAVANMVFDLTAKKLIGF-----SPEKSRKLRKNFDAFFQGLVSFPLYFPGTTFYR 738 + V V ++F + + L+GF SP+ ++L + F+ + L S P+ P + YR Sbjct: 174 LLVYPEVKRLMFRIAMRILLGFQPRQASPDGEQQLVEAFEEMIRNLFSLPIDVPFSGLYR 233 Query: 739 CIQGRKNVQKVLKDLLKERLGA--PEKRHGDFLDEVVDELQSGRGVIDEKFAVDLMAALL 912 ++ R + +++ ++ ++ PE + D L +++ Q ++ + + LL Sbjct: 234 GLRARNIIHAKIEENIRAKMARKEPEGGYKDALQLLMEHTQGNGEQLNMQELKESATELL 293 Query: 913 FASFATVSSSLTIAMKFLSGHPNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQ 1092 F T +S+ T + FL H +V++ +++E + + + E + + +T Sbjct: 294 FGGHETTASAATSLIAFLGLHHDVLQKVRKELQLKGLLSGPNQEKQLNMEFLEQLKYTGC 353 Query: 1093 VTNEISRVSNVAPGIFRKTLTDVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWR 1272 V E R+S PG FR L +++ GY IP GW V+ S H +LF D FNP R Sbjct: 354 VIKETLRLSPPVPGGFRIALKTLELNGYQIPKGWNVIYSICDTHDVADLFTDKDEFNPDR 413 Query: 1273 WQDESKKSTMLKNFMPFGGGIRLCVGAEFSRIQIALFLHTLVTKYRWKEIKGGEVQRISE 1452 + S + + +F+PFGGG+R CVG EF+++ + +F L W+ + G + Sbjct: 414 FMSPSPEDSSRFSFIPFGGGLRSCVGKEFAKVLLKIFTVELARSCDWQLLNGPPTMKTGP 473 Query: 1453 IVFP 1464 IV+P Sbjct: 474 IVYP 477
>Q59990:CP120_SYNY3 Putative cytochrome P450 120 - Synechocystis sp. (strain PCC 6803)| Length = 444 Score = 189 bits (479), Expect = 4e-47 Identities = 123/427 (28%), Positives = 204/427 (47%), Gaps = 1/427 (0%) Frame = +1 Query: 169 LPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEVNR 348 +PPG GLP +GET F F K+R +++GP+FKT L G+ V+ A NR Sbjct: 13 IPPGDFGLPWLGETLNFLNDGD------FGKKRQQQFGPIFKTRLFGKNVIFISGALANR 66 Query: 349 FIFQQEGKLFRSWYPDTANNIFGKESIASYDGSFHKYVRSFASRLFGLDSLRDVLLAEMD 528 F+F +E + F++ +P + + G ++A+ G H+ R + F L D L +MD Sbjct: 67 FLFTKEQETFQATWPLSTRILLGPNALATQMGEIHRSRRKILYQAF-LPRTLDSYLPKMD 125 Query: 529 CNVTDSLAAWAAEPAIEVKDAVANMVFDLTAKKLIGFSPEKSRKLRKNFDAFFQGLVSFP 708 V L W + + M FD+ A +G ++ +L F+ + QGL S P Sbjct: 126 GIVQGYLEQWGKANEVIWYPQLRRMTFDVAATLFMGEKVSQNPQLFPWFETYIQGLFSLP 185 Query: 709 LYFPGTTFYRCIQGRKNVQKVLKDLLKERLGAPEKRHGDFLDEVVDELQSGRGVIDEKFA 888 + P T F + + R + L+ ++K R P D L ++ + Sbjct: 186 IPLPNTLFGKSQRARALLLAELEKIIKARQQQPPSEE-DALGILLAARDDNNQPLSLPEL 244 Query: 889 VDLMAALLFASFATVSSSLTIAMKFLSGHPNVVESLKEEHEAILKKREEGAKSGITWEEY 1068 D + LLFA T++S+L+ L H ++ E +++E + +E +T E Sbjct: 245 KDQILLLLFAGHETLTSALSSFCLLLGQHSDIRERVRQEQNKLQLSQE------LTAETL 298 Query: 1069 KSMTFTAQVTNEISRVSNVAPGIFRKTLTDVQVKGYTIPAGWLVMISPMAVHLNPELFED 1248 K M + QV E+ R+ G FR+ + D Q +G+ P GWLV H +P+L+ D Sbjct: 299 KKMPYLDQVLQEVLRLIPPVGGGFRELIQDCQFQGFHFPKGWLVSYQISQTHADPDLYPD 358 Query: 1249 PLTFNPWRW-QDESKKSTMLKNFMPFGGGIRLCVGAEFSRIQIALFLHTLVTKYRWKEIK 1425 P F+P R+ D S +PFGGG+R C+G EF+R+++ LF L+ ++ W + Sbjct: 359 PEKFDPERFTPDGSATHNPPFAHVPFGGGLRECLGKEFARLEMKLFATRLIQQFDWTLLP 418 Query: 1426 GGEVQRI 1446 G ++ + Sbjct: 419 GQNLELV 425
>O93323:CP26A_XENLA Cytochrome P450 26A1 - Xenopus laevis (African clawed frog)| Length = 492 Score = 188 bits (478), Expect = 5e-47 Identities = 132/460 (28%), Positives = 218/460 (47%), Gaps = 10/460 (2%) Frame = +1 Query: 115 WLAHCVYKWTNPACSTGRLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFK 294 W +C+ + A LPPG+MGLP GET Q L F + + +YG ++K Sbjct: 28 WEVYCLRR--KDAACANPLPPGTMGLPFFGETLQMV-----LQRRRFLQVKRSQYGRIYK 80 Query: 295 TSLVGQPVVVSMDAEVNRFIFQQEGKLFRSWYPDTANNIFGKESIASYDGSFHKYVRSFA 474 T L G P V AE R I E KL +P + I G +++ + HKY + Sbjct: 81 THLFGSPTVRVTGAENVRQILMGEHKLVSVHWPASVRTILGAGCLSNLHDNEHKYTKKVI 140 Query: 475 SRLFGLDSLRDVLLAEMDCNVTDSLAAWAAE-PAIEVKDAVANMVFDLTAKKLIGFSP-- 645 ++ F ++L + + +M+ V S+ W P + V A+ M+F + + L+G P Sbjct: 141 AQAFSREALANYV-PQMEEEVRCSVNLWLQSGPCVLVYPAIKRMMFRIAMRLLLGCDPQR 199 Query: 646 ---EKSRKLRKNFDAFFQGLVSFPLYFPGTTFYRCIQGRKNVQKVLKDLLKERLGA-PEK 813 E+ L + F+ + L S P+ P + YR ++ R + +++ +KE+L P++ Sbjct: 200 MDREQEETLLEAFEEMSRNLFSLPIDVPFSGLYRGLRARNLIHAQIEENIKEKLQREPDE 259 Query: 814 RHGDFLDEVVDELQSGRGVIDEKFAVDLMAALLFASFATVSSSLTIAMKFLSGHPNVVES 993 D L ++D + I+ + + LLF T +S+ T FL+ H +V+E Sbjct: 260 HCKDALQLLIDYSRRNGEPINLQALKESATELLFGGHGTTASAATSLTSFLALHKDVLEK 319 Query: 994 LKEEHEA---ILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAPGIFRKTLTDVQ 1164 +++E E + K EE K ++ E + + +T+ V E R+S G FR L Sbjct: 320 VRKELETQGLLSTKPEE--KKELSIEVLQQLKYTSCVIKETLRLSPPVAGGFRVALKTFV 377 Query: 1165 VKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGIRLC 1344 + GY IP GW V+ S H +LF D FNP R+ + + F+PFGGG+R C Sbjct: 378 LNGYQIPKGWNVIYSIADTHGEADLFPDTDKFNPDRFLTPLPRDSSRFGFIPFGGGVRCC 437 Query: 1345 VGAEFSRIQIALFLHTLVTKYRWKEIKGGEVQRISEIVFP 1464 +G EF++I + +F+ L W+ + G S I+ P Sbjct: 438 IGKEFAKILLKVFVVELCRNCDWELLNGSPAMTTSPIICP 477
>O23051:KAO1_ARATH Ent-kaurenoic acid oxidase 1 - Arabidopsis thaliana (Mouse-ear cress)| Length = 490 Score = 186 bits (472), Expect = 3e-46 Identities = 119/445 (26%), Positives = 206/445 (46%), Gaps = 11/445 (2%) Frame = +1 Query: 115 WLAHCVYKWTNPACSTGR----LPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYG 282 WL V W + S G LPPG +G P +G F + + D +F + +KRYG Sbjct: 24 WLVRKVNVWLYES-SLGENRHYLPPGDLGWPFIGNMLSFLRAFKTSDPDSFTRTLIKRYG 82 Query: 283 P--VFKTSLVGQPVVVSMDAEVNRFIFQQEGKLFRSWYPDTANNIFGKESIASYDGSFHK 456 P ++K + G P ++ ++ R + + F+ +P + + G++S HK Sbjct: 83 PKGIYKAHMFGNPSIIVTTSDTCRRVLTDDDA-FKPGWPTSTMELIGRKSFVGISFEEHK 141 Query: 457 YVRSFASRLFGLDSLRDVLLAEMDCNVTDSLAAWAAEPAIEVKDAVANMVFDLTAKKLIG 636 +R + + ++ NV L W E + + F + + Sbjct: 142 RLRRLTAAPVNGHEALSTYIPYIEENVITVLDKWTKMGEFEFLTHLRKLTFRIIMYIFLS 201 Query: 637 FSPEKSRK-LRKNFDAFFQGLVSFPLYFPGTTFYRCIQGRKNVQKVLKDLLKERLGAPEK 813 E L + + A G+ + + PG ++R ++ RK + + ++ ER ++ Sbjct: 202 SESENVMDALEREYTALNYGVRAMAVNIPGFAYHRALKARKTLVAAFQSIVTERRNQRKQ 261 Query: 814 R----HGDFLDEVVDELQSGRGVIDEKFAVDLMAALLFASFATVSSSLTIAMKFLSGHPN 981 D LD +++ +D++ +D++ L A + ++ A FL HP Sbjct: 262 NILSNKKDMLDNLLNVKDEDGKTLDDEEIIDVLLMYLNAGHESSGHTIMWATVFLQEHPE 321 Query: 982 VVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAPGIFRKTLTDV 1161 V++ K E E ILK R EG K G++ +E + M F +QV +E RV + FR+ TDV Sbjct: 322 VLQRAKAEQEMILKSRPEGQK-GLSLKETRKMEFLSQVVDETLRVITFSLTAFREAKTDV 380 Query: 1162 QVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGIRL 1341 ++ GY IP GW V+ VH++PE+F DP F+P RW + F+PFG G L Sbjct: 381 EMNGYLIPKGWKVLTWFRDVHIDPEVFPDPRKFDPARWDNGFVPKA--GAFLPFGAGSHL 438 Query: 1342 CVGAEFSRIQIALFLHTLVTKYRWK 1416 C G + ++++I++FLH + KY+ K Sbjct: 439 CPGNDLAKLEISIFLHHFLLKYQVK 463
>Q9C5Y2:KAO2_ARATH Ent-kaurenoic acid oxidase 2 - Arabidopsis thaliana (Mouse-ear cress)| Length = 489 Score = 182 bits (461), Expect = 5e-45 Identities = 114/421 (27%), Positives = 196/421 (46%), Gaps = 7/421 (1%) Frame = +1 Query: 169 LPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGP--VFKTSLVGQPVVVSMDAEV 342 LPPG +G P++G + F + + D +F + + RYG ++K + G P V+ E Sbjct: 44 LPPGDLGWPVIGNMWSFLRAFKTSDPESFIQSYITRYGRTGIYKAHMFGYPCVLVTTPET 103 Query: 343 NRFIFQQEGKLFRSWYPDTANNIFGKESIASYDGSFHKYVRSFASRLFGLDSLRDVLLAE 522 R + + W P + + G++S HK +R S V + Sbjct: 104 CRRVLTDDDAFHIGW-PKSTMKLIGRKSFVGISFEEHKRLRRLTSAPVNGPEALSVYIQF 162 Query: 523 MDCNVTDSLAAWAAEPAIEVKDAVANMVFDLTAKKLIGFSPEKSR-KLRKNFDAFFQGLV 699 ++ V L W+ IE + + F + + E L + + G+ Sbjct: 163 IEETVNTDLEKWSKMGEIEFLSHLRKLTFKVIMYIFLSSESEHVMDSLEREYTNLNYGVR 222 Query: 700 SFPLYFPGTTFYRCIQGRKNV----QKVLKDLLKERLGAPEKRHGDFLDEVVDELQSGRG 867 + + PG ++R ++ RK + Q ++ + +R D LD ++D Sbjct: 223 AMGINLPGFAYHRALKARKKLVAAFQSIVTNRRNQRKQNISSNRKDMLDNLIDVKDENGR 282 Query: 868 VIDEKFAVDLMAALLFASFATVSSSLTIAMKFLSGHPNVVESLKEEHEAILKKREEGAKS 1047 V+D++ +DL+ L A + A + HP +++ KEE E I+KKR G K Sbjct: 283 VLDDEEIIDLLLMYLNAGHESSGHLTMWATILMQEHPMILQKAKEEQERIVKKRAPGQK- 341 Query: 1048 GITWEEYKSMTFTAQVTNEISRVSNVAPGIFRKTLTDVQVKGYTIPAGWLVMISPMAVHL 1227 +T +E + M + +QV +E RV + FR+ +DVQ+ GY IP GW V+ VHL Sbjct: 342 -LTLKETREMVYLSQVIDETLRVITFSLTAFREAKSDVQMDGYIIPKGWKVLTWFRNVHL 400 Query: 1228 NPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGIRLCVGAEFSRIQIALFLHTLVTKY 1407 +PE++ DP F+P RW+ + K+ F+PFG G LC G + ++++I++FLH + KY Sbjct: 401 DPEIYPDPKKFDPSRWEGYTPKA---GTFLPFGLGSHLCPGNDLAKLEISIFLHHFLLKY 457 Query: 1408 R 1410 R Sbjct: 458 R 458
>P79739:CP26A_DANRE Cytochrome P450 26A1 - Danio rerio (Zebrafish) (Brachydanio rerio)| Length = 492 Score = 179 bits (455), Expect = 3e-44 Identities = 118/449 (26%), Positives = 212/449 (47%), Gaps = 9/449 (2%) Frame = +1 Query: 145 NPACSTGRLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVV 324 +P C + LPPG+MGLP +GET Q L F + + ++YG ++KT L G P V Sbjct: 37 DPNCRSP-LPPGTMGLPFIGETLQLI-----LQRRKFLRMKRQKYGCIYKTHLFGNPTVR 90 Query: 325 SMDAEVNRFIFQQEGKLFRSWYPDTANNIFGKESIASYDGSFHKYVRSFASRLFGLDSLR 504 M A+ R I E KL +P + I G +++++ G HK + R F D+L Sbjct: 91 VMGADNVRQILLGEHKLVSVQWPASVRTILGSDTLSNVHGVQHKNKKKAIMRAFSRDALE 150 Query: 505 DVLLAEMDCNVTDSLAAWAAEPA-IEVKDAVANMVFDLTAKKLIGFSPEK----SRKLRK 669 + + V ++ W + + + V + ++F + + L+GF PE+ ++L + Sbjct: 151 HYIPV-IQQEVKSAIQEWLQKDSCVLVYPEMKKLMFRIAMRILLGFEPEQIKTDEQELVE 209 Query: 670 NFDAFFQGLVSFPLYFPGTTFYRCIQGRKNVQKVLKDLLKERLGAPEKRHGDFLDEVVDE 849 F+ + L S P+ P + YR ++ R + +++ +++++ + + + + Sbjct: 210 AFEEMIKNLFSLPIDVPFSGLYRGLRARNFIHSKIEENIRKKIQDDDNENEQKYKDALQL 269 Query: 850 LQSGRGVIDEKFAVDLM----AALLFASFATVSSSLTIAMKFLSGHPNVVESLKEEHEAI 1017 L DE F++ M LLF T +S+ T + FL + VV+ ++EE + Sbjct: 270 LIENSRRSDEPFSLQAMKEAATELLFGGHETTASTATSLVMFLGLNTEVVQKVREEVQEK 329 Query: 1018 LKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAPGIFRKTLTDVQVKGYTIPAGWL 1197 ++ G++ E + +T V E R++ PG FR L ++ GY IP GW Sbjct: 330 VEMGMYTPGKGLSMELLDQLKYTGCVIKETLRINPPVPGGFRVALKTFELNGYQIPKGWN 389 Query: 1198 VMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGIRLCVGAEFSRIQIA 1377 V+ S H ++F + F P R+ + + N++PFGGG R+CVG EF+++ + Sbjct: 390 VIYSICDTHDVADVFPNKEEFQPERFMSKGLEDGSRFNYIPFGGGSRMCVGKEFAKVLLK 449 Query: 1378 LFLHTLVTKYRWKEIKGGEVQRISEIVFP 1464 +FL L W G + ++P Sbjct: 450 IFLVELTQHCNWILSNGPPTMKTGPTIYP 478
>Q43246:C88A1_MAIZE Cytochrome P450 88A1 - Zea mays (Maize)| Length = 519 Score = 177 bits (450), Expect = 1e-43 Identities = 131/465 (28%), Positives = 224/465 (48%), Gaps = 15/465 (3%) Frame = +1 Query: 61 YSQVAFASLCG-LAAVVAGWLAHCVYKWTNPAC----STGRLPPGSMGLPLVGETFQFFK 225 Y + A A L G +A VV A + W A RLPPG MG PLVG + F + Sbjct: 31 YREAAEAVLVGAVALVVVDAAARRAHGWYREAALGAARRARLPPGEMGWPLVGGMWAFLR 90 Query: 226 PSPSLDVPAFYKQRLKRYGP--VFKTSLVGQPVVVSMDAEVNRFIFQQEGKLFRSWYPDT 399 S AF ++R+G V+++ + P V+ AE + + + W P Sbjct: 91 AFKSGKPDAFIASFVRRFGRTGVYRSFMFSSPTVLVTTAEGCKQVLMDDDAFVTGW-PKA 149 Query: 400 ANNIFGKESIASYDGSFHKYVRSF-ASRLFGLDSLRDVLLAEMDCNVTDSLAAWAAEP-A 573 + G S + H+ +R A+ + G D+L L +D VT SL AWA + Sbjct: 150 TVALVGPRSFVAMPYDEHRRIRKLTAAPINGFDALTGYL-PFIDRTVTSSLRAWADHGGS 208 Query: 574 IEVKDAVANMVFDLTAKKLIGFSPEKS-RKLRKNFDAFFQGLVSFPLYFPGTTFYRCIQG 750 +E + M F + + +G + + + R L +++ G+ + + PG + ++ Sbjct: 209 VEFLTELRRMTFKIIVQIFLGGADQATTRALERSYTELNYGMRAMAINLPGFAYRGALRA 268 Query: 751 RKNVQKVLKDLLKERLGAPEKRHG----DFLDEVVDELQSGRGV-IDEKFAVDLMAALLF 915 R+ + VL+ +L ER A K D +D ++ E Q RG +D+ +D++ L Sbjct: 269 RRRLVAVLQGVLDERRAARAKGVSGGGVDMMDRLI-EAQDERGRHLDDDEIIDVLVMYLN 327 Query: 916 ASFATVSSSLTIAMKFLSGHPNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQV 1095 A + A FL +P++ K E EAI++ + G+T +++ M + +QV Sbjct: 328 AGHESSGHITMWATVFLQENPDMFARAKAEQEAIMRSIPSSQR-GLTLRDFRKMEYLSQV 386 Query: 1096 TNEISRVSNVAPGIFRKTLTDVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRW 1275 +E R+ N++ FR+ DV V GY IP GW V + +VH++P+++ DP F+P RW Sbjct: 387 IDETLRLVNISFVSFRQATRDVFVNGYLIPKGWKVQLWYRSVHMDPQVYPDPTKFDPSRW 446 Query: 1276 QDESKKSTMLKNFMPFGGGIRLCVGAEFSRIQIALFLHTLVTKYR 1410 + S ++ F+ FG G RLC G + ++++I++FLH + Y+ Sbjct: 447 EGHSPRA---GTFLAFGLGARLCPGNDLAKLEISVFLHHFLLGYK 488
>Q9AXH9:KAO1_HORVU Ent-kaurenoic acid oxidase 1 - Hordeum vulgare (Barley)| Length = 499 Score = 170 bits (431), Expect = 2e-41 Identities = 123/460 (26%), Positives = 220/460 (47%), Gaps = 16/460 (3%) Frame = +1 Query: 79 ASLCGLAAVVAGWLAHCVYKWTNP--ACSTGRLPPGSMGLPLVGETFQFFKPSPSLDVPA 252 A+L +A A AH Y WT A GRLPPG MG PLVG + F + S + Sbjct: 14 AALAVVALDAAVRAAHAWY-WTASLGAGRRGRLPPGDMGWPLVGGMWAFLRAFKSGRPDS 72 Query: 253 FYKQRLKRYGP--VFKTSLVGQPVVVSMDAEVNRFIFQQEGKLFRSWYPDTANNIFGKES 426 F +R+G +++ + P +++ E + + + W P + G +S Sbjct: 73 FIDSFARRFGRAGLYRAFMFSSPTIMATTPEACKQVLMDDDAFVTGW-PKATVALIGPKS 131 Query: 427 IASYDGSFHKYVRSF-ASRLFGLDSLRDVLLAEMDCNVTDSLAAWA---AEPAIEVKDAV 594 + H+ +R A+ + G D+L L +D V +L W+ + E + Sbjct: 132 FVNMGYDEHRRLRKLTAAPINGFDALTSYL-GFIDDTVVTTLRGWSERGGDGHFEFLTEL 190 Query: 595 ANMVFDLTAKKLIGFSPEKSR-KLRKNFDAFFQGLVSFPLYFPGTTFYRCIQGRKNVQKV 771 M F + + +G + E++ +L + + G+ + + PG +++ I+ R+ + Sbjct: 191 RRMTFRIIVQIFMGGADERTAAELERTYTELNYGMRAMAIDLPGFAYHKAIRARRRLVAA 250 Query: 772 LKDLLKERLGAPEKRHG------DFLDEVVD-ELQSGRGVIDEKFAVDLMAALLFASFAT 930 L+ +L ER K D +D ++ E + GR + D++ +D++ L A + Sbjct: 251 LQRVLDERRARGGKTAAGAAAPVDMMDRLIAVEDEGGRRLQDDEI-IDVLVMYLNAGHES 309 Query: 931 VSSSLTIAMKFLSGHPNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEIS 1110 A FL +P ++ K E EAI++ G K G+T +++ M + +QV +E Sbjct: 310 SGHITMWATVFLQENPEILAKAKAEQEAIMRSIPPGQK-GLTLRDFRKMAYLSQVVDETL 368 Query: 1111 RVSNVAPGIFRKTLTDVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESK 1290 R N++ FR+ DV V GY IP GW V + +VH++P+++ DP F+P RW+ Sbjct: 369 RFVNISFVSFRQATRDVFVNGYLIPKGWKVQLWYRSVHMDPQVYPDPKKFDPSRWEGPPP 428 Query: 1291 KSTMLKNFMPFGGGIRLCVGAEFSRIQIALFLHTLVTKYR 1410 ++ F+PFG G RLC G + ++++I++FLH + Y+ Sbjct: 429 RA---GTFLPFGLGTRLCPGNDLAKLEISVFLHHFLLGYK 465
>Q9NR63:CP26B_HUMAN Cytochrome P450 26B1 - Homo sapiens (Human)| Length = 512 Score = 169 bits (427), Expect = 4e-41 Identities = 120/423 (28%), Positives = 212/423 (50%), Gaps = 7/423 (1%) Frame = +1 Query: 169 LPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEVNR 348 +P GSMG PL+GET + L F R ++YG VFKT L+G+P++ AE R Sbjct: 49 IPKGSMGFPLIGETGHWL-----LQGSGFQSSRREKYGNVFKTHLLGRPLIRVTGAENVR 103 Query: 349 FIFQQEGKLFRSWYPDTANNIFGKESIASYDGSFHKYVRSFASRLFGLDSLRDVLLAEMD 528 I E L + +P + + G ++++ G H+ R S++F ++L + L ++ Sbjct: 104 KILMGEHHLVSTEWPRSTRMLLGPNTVSNSIGDIHRNKRKVFSKIFSHEAL-ESYLPKIQ 162 Query: 529 CNVTDSLAAWAAEP-AIEVKDAVANMVFDLTAKKLIGFS-PEKS-RKLRKNFDAFFQGLV 699 + D+L AW++ P AI V + F + + L+GFS PE+ L + + F + Sbjct: 163 LVIQDTLRAWSSHPEAINVYQEAQKLTFRMAIRVLLGFSIPEEDLGHLFEVYQQFVDNVF 222 Query: 700 SFPLYFPGTTFYRCIQGRKNVQKVLKDLLKERLGAPE-KRHGDFLDEVVDELQSGRGVID 876 S P+ P + + R IQ R+ +QK L+ ++E+L + K + D LD +++ + + Sbjct: 223 SLPVDLPFSGYRRGIQARQILQKGLEKAIREKLQCTQGKDYLDALDLLIESSKEHGKEMT 282 Query: 877 EKFAVDLMAALLFASFATVSSSLTIAMKFLSGHPNVVESLKEEHEA--ILKKREEGAKSG 1050 + D L+FA++AT +S+ T + L HP V+E L++E A IL + Sbjct: 283 MQELKDGTLELIFAAYATTASASTSLIMQLLKHPTVLEKLRDELRAHGILHSGGCPCEGT 342 Query: 1051 ITWEEYKSMTFTAQVTNEISRVSNVAPGIFRKTLTDVQVKGYTIPAGWLVMISPMAVHLN 1230 + + + + V E+ R+ G +R L ++ G+ IP GW VM S H Sbjct: 343 LRLDTLSGLRYLDCVIKEVMRLFTPISGGYRTVLQTFELDGFQIPKGWSVMYSIRDTHDT 402 Query: 1231 PELFEDPLTFNPWRW-QDESKKSTMLKNFMPFGGGIRLCVGAEFSRIQIALFLHTLVTKY 1407 +F+D F+P R+ Q S+ +++PFGGG+R C+G +++ + + L + Sbjct: 403 APVFKDVNVFDPDRFSQARSEDKDGRFHYLPFGGGVRTCLGKHLAKLFLKVLAVELASTS 462 Query: 1408 RWK 1416 R++ Sbjct: 463 RFE 465
>Q6EIG3:CP26B_DANRE Cytochrome P450 26B1 - Danio rerio (Zebrafish) (Brachydanio rerio)| Length = 511 Score = 164 bits (414), Expect = 1e-39 Identities = 121/457 (26%), Positives = 218/457 (47%), Gaps = 13/457 (2%) Frame = +1 Query: 169 LPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEVNR 348 +P GSMG P++GET +F F+ R ++YG VFKT L+G+P++ AE R Sbjct: 49 MPKGSMGFPIIGETCHWF-----FQGAGFHASRRQKYGNVFKTHLLGRPLIRVTGAENVR 103 Query: 349 FIFQQEGKLFRSWYPDTANNIFGKESIASYDGSFHKYVRSFASRLFGLDSLRDVLLAEMD 528 + E L +P + + + G S+A+ G H+ R +++F ++L + L ++ Sbjct: 104 KVLMGEHSLVTVDWPQSTSTLLGPNSLANSIGDIHRKRRKIFAKVFSHEAL-ESYLPKIQ 162 Query: 529 CNVTDSLAAWAAEP-AIEVKDAVANMVFDLTAKKLIGF--SPEKSRKLRKNFDAFFQGLV 699 + ++L W++ P I V + F++ + L+GF E+ L F F + + Sbjct: 163 QVIQETLRVWSSNPDPINVYRESQRLSFNMAVRVLLGFRIPEEEMHCLFSTFQEFVENVF 222 Query: 700 SFPLYFPGTTFYRCIQGRKNVQKVLKDLLKER-LGAPEKRHGDFLDEVVDELQSGRGVID 876 S P+ P + + + I+ R ++QK ++ ++E+ L K + D LD +++ + + Sbjct: 223 SLPIDLPFSGYRKGIRARDSLQKSIEKAIREKPLHTQGKDYTDALDVLLESAKENNTELT 282 Query: 877 EKFAVDLMAALLFASFATVSSSLTIAMKFLSGHPNVVESLKEE-------HEAILKKREE 1035 + + L+FA+FAT +S+ T + L HP V+E L+EE H+ L + E Sbjct: 283 MQELKESTIELIFAAFATTASASTSLVMQLLRHPAVLEKLREELRSCGLLHDGCLCQGE- 341 Query: 1036 GAKSGITWEEYKSMTFTAQVTNEISRVSNVAPGIFRKTLTDVQVKGYTIPAGWLVMISPM 1215 + + S+ + V E+ R+ G +R ++ G +P GW VM S Sbjct: 342 -----LRLDSIISLKYLDCVIKEVLRLFAPVSGGYRIATQTFELDGVQVPKGWSVMYSIR 396 Query: 1216 AVHLNPELFEDPLTFNPWRWQDESKKSTMLK-NFMPFGGGIRLCVGAEFSRIQIALFLHT 1392 H +F+D F+P R+ E + + +++PFGGG+R C+G + L T Sbjct: 397 DTHDTSAVFKDVEAFDPDRFSPERSEDREGRFHYLPFGGGVRSCLGKQ---------LAT 447 Query: 1393 LVTKYRWKEIKGGEVQRISEIVFPEGYHIQII-PREG 1500 L K E+ GG +S FP + ++ P +G Sbjct: 448 LFLKLLAVELAGGSRFELSTRTFPRMISVPVVHPTDG 484
>O55127:CP26A_MOUSE Cytochrome P450 26A1 - Mus musculus (Mouse)| Length = 497 Score = 163 bits (413), Expect = 2e-39 Identities = 125/465 (26%), Positives = 217/465 (46%), Gaps = 15/465 (3%) Frame = +1 Query: 115 WLAHCVYKWTNPACSTGRLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFK 294 W +CV + +C+ LPPG+MG P GET Q L F + + ++YG ++K Sbjct: 28 WDLYCVSS-RDRSCALP-LPPGTMGFPFFGETLQMV-----LQRRKFLQMKRRKYGFIYK 80 Query: 295 TSLVGQPVVVSMDAEVNRFIFQQEGKLFRSWYPDTANNIFGKESIASYDGSFHKYVRSFA 474 T L G+P V M A+ R I E +L +P + I G +++ S HK + Sbjct: 81 THLFGRPTVRVMGADNVRRILLGEHRLVSVHWPASVRTILGAGCLSNLHDSSHKQRKKVI 140 Query: 475 SRLFGLDSLRDVLLAEMDCNVTDSLAAWAA--EPAIEVKDAVANMVFDLTAKKLIGFSP- 645 + F ++L+ +L + V+ L W + E + V V ++F + + L+G P Sbjct: 141 MQAFSREALQCYVLVIAE-EVSSCLEQWLSCGERGLLVYPEVKRLMFRIAMRILLGCEPG 199 Query: 646 -----EKSRKLRKNFDAFFQGLVSFPLYFPGTTFYRCIQGRKNVQKVLKDLLK---ERLG 801 E ++L + F+ + L S P+ P + YR ++ R + +++ ++ RL Sbjct: 200 PAGGGEDEQQLVEAFEEMTRNLFSLPIDVPFSGLYRGVKARNLIHARIEENIRAKIRRLQ 259 Query: 802 APEKRHG--DFLDEVVDELQSGRGVIDEKFAVDLMAALLFASFATVSSSLTIAMKFLSGH 975 A E G D L +++ +D + LLF T +S+ T + +L + Sbjct: 260 ATEPDGGCKDALQLLIEHSWERGERLDMQALKQSSTELLFGGHETTASAATSLITYLGLY 319 Query: 976 PNVVESLKEE--HEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAPGIFRKT 1149 P+V++ ++EE + +L K + K + E + + + V E R++ PG FR Sbjct: 320 PHVLQKVREEIKSKGLLCKSNQDNK--LDMETLEQLKYIGCVIKETLRLNPPVPGGFRVA 377 Query: 1150 LTDVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGG 1329 L ++ GY IP GW V+ S H ++F + FNP R+ + +F+PFGG Sbjct: 378 LKTFELNGYQIPKGWNVIYSICDTHDVADIFTNKEEFNPDRFIVPHPEDASRFSFIPFGG 437 Query: 1330 GIRLCVGAEFSRIQIALFLHTLVTKYRWKEIKGGEVQRISEIVFP 1464 G+R CVG EF++I + +F L W+ + G + S V+P Sbjct: 438 GLRSCVGKEFAKILLKIFTVELARHCDWQLLNGPPTMKTSPTVYP 482
>O43174:CP26A_HUMAN Cytochrome P450 26A1 - Homo sapiens (Human)| Length = 497 Score = 162 bits (409), Expect = 5e-39 Identities = 125/470 (26%), Positives = 217/470 (46%), Gaps = 15/470 (3%) Frame = +1 Query: 100 AVVAGWLAHCVYKWTNPACSTGRLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRY 279 A + W +CV + +C+ LPPG+MG P GET Q L F + + ++Y Sbjct: 23 AAIKLWDLYCV-SGRDRSCALP-LPPGTMGFPFFGETLQMV-----LQRRKFLQMKRRKY 75 Query: 280 GPVFKTSLVGQPVVVSMDAEVNRFIFQQEGKLFRSWYPDTANNIFGKESIASYDGSFHKY 459 G ++KT L G+P V M A+ R I + +L +P + I G +++ S HK Sbjct: 76 GFIYKTHLFGRPTVRVMGADNVRRILLGDDRLVSVHWPASVRTILGSGCLSNLHDSSHKQ 135 Query: 460 VRSFASRLFGLDSLRDVLLAEMDCNVTDSLAAWAA--EPAIEVKDAVANMVFDLTAKKLI 633 + R F ++L + + + V SL W + E + V V ++F + + L+ Sbjct: 136 RKKVIMRAFSREAL-ECYVPVITEEVGSSLEQWLSCGERGLLVYPEVKRLMFRIAMRILL 194 Query: 634 GFSPE------KSRKLRKNFDAFFQGLVSFPLYFPGTTFYRCIQGRKNVQKVLKDLLKER 795 G P+ ++L + F+ + L S P+ P + YR ++ R + ++ ++ + Sbjct: 195 GCEPQLAGDGDSEQQLVEAFEEMTRNLFSLPIDVPFSGLYRGMKARNLIHARIEQNIRAK 254 Query: 796 ---LGAPEKRHG--DFLDEVVDELQSGRGVIDEKFAVDLMAALLFASFATVSSSLTIAMK 960 L A E G D L +++ +D + LLF T +S+ T + Sbjct: 255 ICGLRASEAGQGCKDALQLLIEHSWERGERLDMQALKQSSTELLFGGHETTASAATSLIT 314 Query: 961 FLSGHPNVVESLKEE--HEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAPG 1134 +L +P+V++ ++EE + +L K + K + E + + + V E R++ PG Sbjct: 315 YLGLYPHVLQKVREELKSKGLLCKSNQDNK--LDMEILEQLKYIGCVIKETLRLNPPVPG 372 Query: 1135 IFRKTLTDVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNF 1314 FR L ++ GY IP GW V+ S H E+F + FNP R+ + +F Sbjct: 373 GFRVALKTFELNGYQIPKGWNVIYSICDTHDVAEIFTNKEEFNPDRFMLPHPEDASRFSF 432 Query: 1315 MPFGGGIRLCVGAEFSRIQIALFLHTLVTKYRWKEIKGGEVQRISEIVFP 1464 +PFGGG+R CVG EF++I + +F L W+ + G + S V+P Sbjct: 433 IPFGGGLRSCVGKEFAKILLKIFTVELARHCDWQLLNGPPTMKTSPTVYP 482
>Q6V0L0:CP26C_HUMAN Cytochrome P450 26C1 - Homo sapiens (Human)| Length = 522 Score = 153 bits (387), Expect = 2e-36 Identities = 133/488 (27%), Positives = 221/488 (45%), Gaps = 35/488 (7%) Frame = +1 Query: 58 GYSQVAFASLCGLAAVVAGWLAHCV-YKWT------NPACSTGRLPPGSMGLPLVGETFQ 216 G S ++ G A + AG L + WT ST LP GSMG P GET Sbjct: 5 GLSCLSVLGAAGTALLCAGLLLSLAQHLWTLRWMLSRDRASTLPLPKGSMGWPFFGETLH 64 Query: 217 FFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEVNRFIFQQEGKLFRSWYPD 396 + + F+ R +RYG VFKT L+G+PV+ AE R I E +L RS +P Sbjct: 65 WL-----VQGSRFHSSRRERYGTVFKTHLLGRPVIRVSGAENVRTILLGEHRLVRSQWPQ 119 Query: 397 TANNIFGKESIASYDGSFHKYVRSFASRLFGLDSLRDVLLAEMDCNVTDSLAAW-AAEPA 573 +A+ + G ++ G H+ R +R+F +L + + + + + +W AA Sbjct: 120 SAHILLGSHTLLGAVGEPHRRRRKVLARVFSRAAL-ERYVPRLQGALRHEVRSWCAAGGP 178 Query: 574 IEVKDAVANMVFDLTAKKLIGFSPEKSR--KLRKNFDAFFQGLVSFPLYFPGTTFYRCIQ 747 + V DA + F + A+ L+G ++++ L + F+ + L S PL P + + I+ Sbjct: 179 VSVYDASKALTFRMAARILLGLRLDEAQCATLARTFEQLVENLFSLPLDVPFSGLRKGIR 238 Query: 748 GRKNVQKVLKDLLKERLGAPEKRH-GDFLDEVVDELQSGRGVIDEKFAVDLMAA---LLF 915 R + + L+ + E+L + GD LD ++ S R + E +L + LLF Sbjct: 239 ARDQLHRHLEGAISEKLHEDKAAEPGDALDLII---HSARELGHEPSMQELKESAVELLF 295 Query: 916 ASFATVSSSLTIAMKFLSGHPNVVESLKEEHEAILKKREEGAKSG--------------- 1050 A+F T +S+ T + L HP + ++EE A R G G Sbjct: 296 AAFFTTASASTSLVLLLLQHPAAIAKIREELVAQGLGRACGCAPGAAGGSEGPPPDCGCE 355 Query: 1051 --ITWEEYKSMTFTAQVTNEISRVSNVAPGIFRKTLTDVQVKGYTIPAGWLVMISPMAVH 1224 ++ + + V E+ R+ G +R L ++ GY IP GW VM S H Sbjct: 356 PDLSLAALGRLRYVDCVVKEVLRLLPPVSGGYRTALRTFELDGYQIPKGWSVMYSIRDTH 415 Query: 1225 LNPELFEDPLT-FNPWRW---QDESKKSTMLKNFMPFGGGIRLCVGAEFSRIQIALFLHT 1392 ++ P F+P R+ +++S+ ++ +++PFGGG R C+G E ++ + L Sbjct: 416 ETAAVYRSPPEGFDPERFGAAREDSRGASSRFHYIPFGGGARSCLGQELAQAVLQLLAVE 475 Query: 1393 LVTKYRWK 1416 LV RW+ Sbjct: 476 LVRTARWE 483
>O09158:CP3AP_MOUSE Cytochrome P450 3A25 - Mus musculus (Mouse)| Length = 503 Score = 121 bits (304), Expect = 8e-27 Identities = 113/435 (25%), Positives = 191/435 (43%), Gaps = 33/435 (7%) Frame = +1 Query: 175 PGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEVNRFI 354 PG LPL+G F ++ D + K+YG ++ QP++ MD E+ + + Sbjct: 39 PGPKPLPLLGTIFNYYDGMWKFDEDCY-----KKYGKIWGFYEGPQPILAIMDPEIIKIV 93 Query: 355 FQQEGKLFRSWYPDTANNIFG-----KESIASYDGSFHKYVRSFASRLFGLDSLRD---V 510 +E + T FG K++I + K +R+ S F L++ + Sbjct: 94 LVKE-----CYSVFTNRRFFGPVGFMKKAITISEDEEWKRLRTLLSPTFTSGKLKEMFPI 148 Query: 511 LLAEMDCNVTDSLAAWAAEPAIEVKDAVANMVFDLTAKKLIGFSPE-----------KSR 657 + D V + I +KD D+ G + + K++ Sbjct: 149 MRQYGDILVRNLRREEEKGEPISMKDIFGAYSMDVITGTSFGVNVDSLNNPQDPFVQKAK 208 Query: 658 KLRKN--FDAFFQGLVSFPLYFPGTTFYRCIQ-------GRKNVQKVLKDLLKERLGAPE 810 K+ K FD F ++ FP P Y + +K +K + KERL + + Sbjct: 209 KILKFKIFDPFLLSIILFPFLTP---IYEMLNFSIFPRDSMNFFKKFVKRMKKERLASNQ 265 Query: 811 KRHGDFLDEVVDELQSGRGVIDEKFAVDL-MAA----LLFASFATVSSSLTIAMKFLSGH 975 K DFL +++ Q+ +G +K DL MAA +F + S+S+++ M L+ H Sbjct: 266 KNRVDFL-QLMMNTQNSKGQESQKALSDLEMAAQAVIFIFGGYDATSTSISLIMYELATH 324 Query: 976 PNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAPGIFRKTLT 1155 P+V + L++E + L K+ +T++ M + V NE R+ +A + R + Sbjct: 325 PDVQKKLQDEIDRTLPN-----KAPVTYDALMDMEYLDMVVNESLRLYPIAIRLERVSKK 379 Query: 1156 DVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGI 1335 DV++ G IP G +VMI +H NPE + +P F P R+ E+K + +MPFG G Sbjct: 380 DVEINGVFIPKGTVVMIPIYPLHRNPEYWPEPQEFCPERFSKENKGNIDPYIYMPFGNGP 439 Query: 1336 RLCVGAEFSRIQIAL 1380 R C+G F+ I I L Sbjct: 440 RNCIGMRFALISIKL 454
>P05184:CP3A3_HUMAN Cytochrome P450 3A3 - Homo sapiens (Human)| Length = 504 Score = 120 bits (301), Expect = 2e-26 Identities = 112/447 (25%), Positives = 196/447 (43%), Gaps = 26/447 (5%) Frame = +1 Query: 175 PGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEVNRFI 354 PG LP +G + K D+ K+YG V+ QPV+ D ++ + + Sbjct: 39 PGPTPLPFLGNILSYHKGFCMFDMECH-----KKYGKVWGFYDGQQPVLAITDPDMIKLV 93 Query: 355 FQQEG-KLFRSWYPDTANNIFGKESIASYDGSFHKYVRSFASRLFGLDSLRDV--LLAEM 525 +E +F + P F K +I+ + K +RS S F L+++ ++A+ Sbjct: 94 LVKECYSVFTNREPFGPVG-FMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQY 152 Query: 526 -DCNVTDSLAAWAAEPAIEVKDAVANMVFDLTAKKLIGFSPEK------------SRKLR 666 D V + + +KD D+ G + + + LR Sbjct: 153 GDVLVRNLRRERETGKPVTLKDVFGAYSMDVITSSSFGVNVDSLNNPQDPLVENTKKLLR 212 Query: 667 KNF-DAFFQGLVSFPLYFPGTTFYR-CIQGRKN---VQKVLKDLLKERLGAPEKRHGDFL 831 +F D FF + FP P C+ R+ ++K +K + + RL +K DFL Sbjct: 213 FDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKAVKRMKESRLEDTQKHRVDFL 272 Query: 832 DEVVDELQSGRGVIDEKFAVDLMAA-----LLFASFATVSSSLTIAMKFLSGHPNVVESL 996 ++D ++ + K DL +FA + T SS L+ M L+ HP+V + L Sbjct: 273 QLMIDSHKNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKL 332 Query: 997 KEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAPGIFRKTLTDVQVKGY 1176 +EE +A+L K+ T++ M + V NE R+ +A + R DV++ G Sbjct: 333 QEEIDAVLPN-----KAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGM 387 Query: 1177 TIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGIRLCVGAE 1356 IP GW+VMI A+H +P+ + +P F P R+ ++K + + PFG G R C+G Sbjct: 388 FIPKGWVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMR 447 Query: 1357 FSRIQIALFLHTLVTKYRWKEIKGGEV 1437 F+ + + L L ++ + +K K ++ Sbjct: 448 FALMNMKLALIRVLQNFSFKPCKETQI 474
>P05179:CP2C7_RAT Cytochrome P450 2C7 - Rattus norvegicus (Rat)| Length = 490 Score = 118 bits (295), Expect = 9e-26 Identities = 116/450 (25%), Positives = 196/450 (43%), Gaps = 31/450 (6%) Frame = +1 Query: 166 RLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEVN 345 +LPPG LP++G Q + S + F K YGPVF L QP V+ E Sbjct: 28 KLPPGPTPLPIIGNFLQIDVKNISQSLTKFSKT----YGPVFTLYLGSQPTVILHGYEAI 83 Query: 346 RFIFQQEGKLF--RSWYPDTANNIFGKESIASYDGSFHKYVRSFASRLF-----GLDSLR 504 + G+ F R YP N G + S +G+ K +R F F G ++ Sbjct: 84 KEALIDNGEKFSGRGSYPMNENVTKGFGIVFS-NGNRWKEMRRFTIMNFRNLGIGKRNIE 142 Query: 505 DVLLAEMDCNVTD--SLAAWAAEPAIEVKDAVANMV--------FDLTAKKLIGFSPEKS 654 D + E C V + +P++ + A N++ FD K+++ F + + Sbjct: 143 DRVQEEAQCLVEELRKTKGSPCDPSLILNCAPCNVICSITFQNHFDYKDKEMLTFMEKVN 202 Query: 655 RKLRKNFDAFFQGLVSFPL---YFPGTTFYRCIQGRKNVQKVLKDLLK------ERLGAP 807 L+ + Q SFP YFPGT + KN+ + LLK E L Sbjct: 203 ENLKIMSSPWMQVCNSFPSLIDYFPGTHH----KIAKNINYMKSYLLKKIEEHQESLDVT 258 Query: 808 EKRHGDFLDEVVDELQSGRGVIDEKFAVDLMAA----LLFASFATVSSSLTIAMKFLSGH 975 R DF+D + + + + +++ + + L+ A T+S++L A+ L + Sbjct: 259 NPR--DFVDYYLIKQKQANNIEQSEYSHENLTCSIMDLIGAGTETMSTTLRYALLLLMKY 316 Query: 976 PNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAPGIFRKTLT 1155 P+V ++EE + ++ G ++ K M +T + +E+ R N P +T Sbjct: 317 PHVTAKVQEEIDRVI-----GRHRSPCMQDRKHMPYTDAMIHEVQRFINFVPTNLPHAVT 371 Query: 1156 -DVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGG 1332 D++ + Y IP G V+ S +V + + F +P F+P + DE+ F+PF G Sbjct: 372 CDIKFRNYLIPKGTKVLTSLTSVLHDSKEFPNPEMFDPGHFLDENGNFKKSDYFLPFSAG 431 Query: 1333 IRLCVGAEFSRIQIALFLHTLVTKYRWKEI 1422 R CVG +R+Q+ LFL T++ + K + Sbjct: 432 KRACVGEGLARMQLFLFLTTILQNFNLKSL 461
>P10632:CP2C8_HUMAN Cytochrome P450 2C8 - Homo sapiens (Human)| Length = 490 Score = 116 bits (290), Expect = 3e-25 Identities = 116/477 (24%), Positives = 204/477 (42%), Gaps = 30/477 (6%) Frame = +1 Query: 151 ACSTGRLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSM 330 +C +LPPG LP++G Q D+ + K YGPVF P+VV Sbjct: 23 SCRRRKLPPGPTPLPIIGNMLQI----DVKDICKSFTNFSKVYGPVFTVYFGMNPIVVFH 78 Query: 331 DAEVNRFIFQQEGKLFRSWYPDTANNIFGKE-SIASYDGSFHKYVRSFAS---RLFGLD- 495 E + G+ F + K I S +G K +R F+ R FG+ Sbjct: 79 GYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGKRWKEIRRFSLTTLRNFGMGK 138 Query: 496 -SLRDVLLAEMDCNVTD--SLAAWAAEPAIEVKDAVANMVFDLTAKKLIGFSPEKSRKLR 666 S+ D + E C V + A +P + A N++ + +K + + L Sbjct: 139 RSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICSVVFQKRFDYKDQNFLTLM 198 Query: 667 KNFDAFFQGLVS--------FPLY---FPGTTFYRCIQGRKNVQKVLKDLLKERLGAPEK 813 K F+ F+ L S FPL FPGT + ++ + +++ +KE + + Sbjct: 199 KRFNENFRILNSPWIQVCNNFPLLIDCFPGT-HNKVLKNVALTRSYIREKVKEHQASLDV 257 Query: 814 RHG-DFLDEVVDELQSGRGVIDEKFAVD----LMAALLFASFATVSSSLTIAMKFLSGHP 978 + DF+D + +++ + +F ++ +A L A T S++L + L HP Sbjct: 258 NNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHP 317 Query: 979 NVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAP-GIFRKTLT 1155 V ++EE + ++ G ++ M +T V +EI R S++ P G+ T Sbjct: 318 EVTAKVQEEIDHVI-----GRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVPHAVTT 372 Query: 1156 DVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGI 1335 D + + Y IP G +M +V + + F +P F+P + D++ FMPF G Sbjct: 373 DTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFKKSDYFMPFSAGK 432 Query: 1336 RLCVGAEFSRIQIALFLHTLVTKYRWK---EIKGGEVQRISE--IVFPEGYHIQIIP 1491 R+C G +R+++ LFL T++ + K ++K +++ + P Y I IP Sbjct: 433 RICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSLPPSYQICFIP 489
>P56656:CP239_MOUSE Cytochrome P450 2C39 - Mus musculus (Mouse)| Length = 490 Score = 114 bits (286), Expect = 1e-24 Identities = 115/481 (23%), Positives = 209/481 (43%), Gaps = 33/481 (6%) Frame = +1 Query: 151 ACSTGRLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSM 330 +C G LPPG P++G Q + S + F K YGPVF L +P VV Sbjct: 23 SCGRGSLPPGPTPFPIIGNFLQIDMKNFSQSLTNFSKA----YGPVFTLYLGSRPTVVLH 78 Query: 331 DAEVNRFIFQQEGKLF--RSWYP--DTANNIFGKESIASYDGSFHKYVRSFASRLF---- 486 E + G+ F R P + NN G I +G+ K +R F Sbjct: 79 GYEAVKEALIDHGEEFSDRGSIPMVEKINNGLG---IVFSNGNRWKEIRRFTLTTLRNLG 135 Query: 487 -GLDSLRDVLLAEMDCNVTD--SLAAWAAEPAIEVKDAVANMV--------FDLTAKKLI 633 G ++ D + E C V + +P + A N++ FD K + Sbjct: 136 MGKRNIEDRVQEEAQCLVEELRKTKGSPCDPTFILSCAPCNVICSIIFQDRFDYKDKDFL 195 Query: 634 GFSPEKSRKLRKNFDAFFQGLVSFPL---YFPGTTFYRCIQGRKNVQKVLKDLLKERLGA 804 + + ++ + Q +FPL Y PG+ ++ ++ K ++ L + +KE + Sbjct: 196 MLMEKLNENVKILSSPWLQVCNNFPLLIDYCPGS-HHKVLKNVKYIRSYLLEKIKEHQES 254 Query: 805 PEKRHG-DFLDEVVDELQSGRGVIDEKFAVDLMAALLFASFA----TVSSSLTIAMKFLS 969 + + DF+D + + + + +F+++ +A + FA T S++L A+ L Sbjct: 255 LDVTNPRDFIDYYLIKQKQANHIQQAEFSLENLACTINNLFAAGTETTSTTLRYALLLLM 314 Query: 970 GHPNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAPGIFRKT 1149 +P+V ++EE + ++ G ++ M +T + +E+ R N+ P + Sbjct: 315 KYPDVTAKVQEEIDHVI-----GRHRSPCMQDRNHMPYTDAMIHEVQRFINLVPNNIPRA 369 Query: 1150 LT-DVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFG 1326 +T D++ + Y IP G V+ S +V + + F +P F+P + D + +FMPF Sbjct: 370 VTCDIKFRNYLIPKGTTVVTSLTSVLHDSKEFPNPELFDPGHFLDANGNFKKSDHFMPFS 429 Query: 1327 GGIRLCVGAEFSRIQIALFLHTLVTKYRWKE-IKGGEVQRI----SEIVFPEGYHIQIIP 1491 G R+C G +R+++ LFL T++ ++ K + ++ I I P Y + IIP Sbjct: 430 AGKRVCAGEGLARMELFLFLTTILQNFKLKPLVHPKDIDMIPFVNGLIALPPHYQVCIIP 489 Query: 1492 R 1494 R Sbjct: 490 R 490
>Q64581:CP3AI_RAT Cytochrome P450 3A18 - Rattus norvegicus (Rat)| Length = 497 Score = 114 bits (285), Expect = 1e-24 Identities = 113/435 (25%), Positives = 189/435 (43%), Gaps = 33/435 (7%) Frame = +1 Query: 175 PGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEVNRFI 354 PG +PL G F + D + K+YG ++ QP + MD E+ + + Sbjct: 39 PGPKPVPLFGTIFNYGDGMWKFDDDCY-----KKYGKIWGFYEGPQPFLAIMDPEIIKMV 93 Query: 355 FQQEGKLFRSWYPDTANNIFG-----KESIASYDGSFHKYVRSFASRLFGLDSLRDV--L 513 +E + T FG K++I + K +R+ S F L+++ L Sbjct: 94 LVKE-----CYSVFTNRRCFGPMGFMKKAITMSEDEEWKRLRTILSPTFTSGKLKEMFPL 148 Query: 514 LAEMDCNVTDSLAAWAAE-PAIEVKDAVANMVFDLTAKKLIGFSPE-----------KSR 657 + + + +L A+ I +KD D+ G + + K++ Sbjct: 149 MRQYGDTLLKNLRREEAKGEPINMKDIFGAYSMDVITGTSFGVNVDSLNNPQDPFVQKAK 208 Query: 658 KLRKN--FDAFFQGLVSFPLYFPGTTFYRCI-------QGRKNVQKVLKDLLKERLGAPE 810 K+ K FD F +V FP P Y + Q +K +K + K RL + + Sbjct: 209 KILKFQIFDPFLLSVVLFPFLTP---IYEMLNFSIFPRQSMNFFKKFVKTMKKNRLDSNQ 265 Query: 811 KRHGDFLDEVVDELQSGRGVIDEKFAVDL-MAA----LLFASFATVSSSLTIAMKFLSGH 975 K DFL +++ Q+ +G +K DL MAA +F + S+S++ M L+ Sbjct: 266 KNRVDFL-QLMMNTQNSKGQESQKALSDLEMAAQAIIFIFGGYDATSTSISFIMYELATR 324 Query: 976 PNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAPGIFRKTLT 1155 PNV + L+ E + L K+ +T++ M + V NE R+ +A + R + Sbjct: 325 PNVQKKLQNEIDRALPN-----KAPVTYDALMEMEYLDMVVNESLRLYPIATRLDRVSKK 379 Query: 1156 DVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGI 1335 DV++ G IP G +V I +H NPE + +P FNP R+ E+K S ++PFG G Sbjct: 380 DVEINGVFIPKGTVVTIPIYPLHRNPEYWLEPEEFNPERFSKENKGSIDPYVYLPFGNGP 439 Query: 1336 RLCVGAEFSRIQIAL 1380 R C+G F+ I + L Sbjct: 440 RNCIGMRFALISMKL 454
>P33262:CP2CK_MACFA Cytochrome P450 2C20 - Macaca fascicularis (Crab eating macaque)| (Cynomolgus monkey) Length = 490 Score = 114 bits (284), Expect = 2e-24 Identities = 120/480 (25%), Positives = 204/480 (42%), Gaps = 35/480 (7%) Frame = +1 Query: 157 STGR--LPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSM 330 S+GR LPPG LP++G Q D+ + K YGPVF PVVV Sbjct: 23 SSGRRKLPPGPTPLPIIGNILQI----DVKDICKSFSNFSKVYGPVFTVYFGMNPVVVLH 78 Query: 331 DAEVNRFIFQQEGKLF--RSWYPDTANNIFGKESIASYDGSFHKYVRSFAS---RLFGLD 495 E + + F R P + I I S +G K R F+ R FG+ Sbjct: 79 GYETVKEALIDNAEEFSGRGILP-ISERITNGLGIISSNGKRWKETRRFSLTTLRNFGMG 137 Query: 496 --SLRDVLLAEMDCNVTD--SLAAWAAEPAIEVKDAVANMVFDLTAKKLIGFSPEKSRKL 663 S+ D + E C V + A +P + A N++ + +K + E L Sbjct: 138 KRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSVVFQKRFDYKDENFLTL 197 Query: 664 RKNFDAFFQGLVS--------FPLY---FPGTTFYRCIQGRKNVQKVLKDLLKERLGAPE 810 K F F+ L S FPL FPGT + ++ + +++ +KE + Sbjct: 198 IKRFTVNFRILTSPWIQVCNNFPLLIDCFPGT-HNKLLKNVALTKSYIREKVKEHQATLD 256 Query: 811 KRHG-DFLDEVVDELQSGRGVIDEKFAVD----LMAALLFASFATVSSSLTIAMKFLSGH 975 + DF+D + +++ + +F ++ +A L A T S++L + L H Sbjct: 257 VNNPRDFIDCFLIKMEQEKDNQQSEFTIENLVGTVADLFVAGTETTSTTLRYGLLLLLKH 316 Query: 976 PNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAP-GIFRKTL 1152 P V ++EE + ++ G ++ M +T V +EI R ++ P G+ Sbjct: 317 PEVTAKVQEEIDHVI-----GRHRSPCMQDRSHMPYTDAVIHEIQRYIDLVPTGVPHAVT 371 Query: 1153 TDVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGG 1332 TD++ + Y IP G +++ +V + + F +P F+P + DE+ FMPF G Sbjct: 372 TDIKFRNYLIPKGTIIITLLTSVLHDDKEFPNPKIFDPGHFLDENGNFKKSDYFMPFSAG 431 Query: 1333 IRLCVGAEFSRIQIALFLHTLVTKYRWKEIKGGEVQRISE-------IVFPEGYHIQIIP 1491 R+C G +R+++ LFL T++ + K + +++ ++ I P Y I IP Sbjct: 432 KRICAGEGLARMELFLFLTTILQNFNLKSV--ADLKNLNTTSATRGIISLPPSYQICFIP 489
>O62671:CP241_CANFA Cytochrome P450 2C41 - Canis familiaris (Dog)| Length = 489 Score = 114 bits (284), Expect = 2e-24 Identities = 116/452 (25%), Positives = 191/452 (42%), Gaps = 32/452 (7%) Frame = +1 Query: 163 GRLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVV--SMDA 336 G+LPPG LP +G Q K D+ K YGPVF +P VV DA Sbjct: 27 GKLPPGPTPLPFIGNILQLDK-----DINKSLSNLSKAYGPVFTLYFGMKPTVVLHGYDA 81 Query: 337 EVNRFIFQQEGKLFRSWYPDTANNIFGKESIASYDGSFHKYVRSFASRLFGLDSLRDVLL 516 I E R +P A + G I G+ K +R FA L +LR++ + Sbjct: 82 VKETLIDLGEEFSARGRFP-IAEKVSGGHGIIFTSGNRWKEMRRFA-----LTTLRNLGM 135 Query: 517 AEMD---------CNVTDSLA---AWAAEPAIEVKDAVANMV--------FDLTAKKLIG 636 + D C + + L A +P + A N++ FD T + LIG Sbjct: 136 GKSDLESRVQEEACYLVEELRKTNALPCDPTFVLGCASCNVICSIIFQNRFDYTDQTLIG 195 Query: 637 FSPEKSRKLRKNFDAFFQGLVSFPL---YFPGT--TFYRCIQGRKNVQKVLKDLLKERLG 801 F + + R + Q SFP Y PG+ T ++ K+ +L+ + + + Sbjct: 196 FLEKLNENFRILSSPWIQAYNSFPALLHYLPGSHNTIFKNFAFIKSY--ILEKIKEHQES 253 Query: 802 APEKRHGDFLDEVVDELQSGRGVIDEKFAVD----LMAALLFASFATVSSSLTIAMKFLS 969 DF+D + +++ + +F + + L A T S++L + L Sbjct: 254 FDVNNPRDFIDYFLIKMEQEKHNQPLEFTFENLKTIATDLFGAGTETTSTTLRYGLLLLL 313 Query: 970 GHPNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAPGIFRKT 1149 HP V ++EE + ++ G ++ M +T V +EI R ++ P Sbjct: 314 KHPEVTVKVQEEIDRVI-----GRHQSPHMQDRSRMPYTNAVLHEIQRYIDLVPNSLPHA 368 Query: 1150 LT-DVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFG 1326 +T DV+ + Y IP G ++IS +V + + F P F+P + D+S FM F Sbjct: 369 VTCDVKFRNYVIPKGTTILISLSSVLSDEKEFPRPEIFDPAHFLDDSGNFKKSDYFMAFS 428 Query: 1327 GGIRLCVGAEFSRIQIALFLHTLVTKYRWKEI 1422 G R+CVG +R+++ LFL T++ K+ K + Sbjct: 429 AGKRICVGEGLARMELFLFLTTILQKFTLKPL 460
>P56593:CP2AC_MOUSE Cytochrome P450 2A12 - Mus musculus (Mouse)| Length = 492 Score = 113 bits (283), Expect = 2e-24 Identities = 112/467 (23%), Positives = 199/467 (42%), Gaps = 23/467 (4%) Frame = +1 Query: 163 GRLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEV 342 G+LPPG + LP +G Q + DV + Q + YGPVF L + VVV + Sbjct: 30 GKLPPGPIPLPFIGNYLQLNRK----DVYSSITQLQEHYGPVFTIHLGPRRVVVLYGYDA 85 Query: 343 NRFIFQQEGKLFRSWYPD-TANNIFGKESIASYDGSFHKYVRSFAS---RLFGLDS--LR 504 + + F T N +F +A +G K +R F+ R FG+ + Sbjct: 86 VKEALVDHAEEFSGRGEQATFNTLFKGYGVAFSNGERAKQLRRFSIATLRDFGMGKRGVE 145 Query: 505 DVLLAEMDCNVTDSLAAWAA--EPAIEVKDAVANMVFDLTAKKLIGFSPEKSRKLRK--- 669 + + E C + A +P I + +N++ + + ++ L + Sbjct: 146 EHIQEEAGCLIKMLQGTCGAPIDPTIYLSKTASNVISSIVFGDRFNYEDKEFLSLLQMMG 205 Query: 670 ---NFDAFFQGLV-----SFPLYFPGTTFYRCIQGRKNVQKVLKDLLKERLGAPEKRHGD 825 F A G + S Y PG K +++ + + + D Sbjct: 206 QVNKFAASPTGQLYDMFHSVMKYLPGPQQQIIKDSHKLEDFMIQKVKQNQSTLDPNSPRD 265 Query: 826 FLDEVVDELQSGRGVIDEKFAVDLMAA---LLFASFATVSSSLTIAMKFLSGHPNVVESL 996 F+D + +Q + V E +L+ L FA TVSS+L L HP+V + Sbjct: 266 FIDSFLIHMQKEKYVNSEFHMKNLVMTSLNLFFAGSETVSSTLRYGFLLLMKHPDVEAKV 325 Query: 997 KEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAP-GIFRKTLTDVQVKG 1173 EE + ++ + + +E++ M +T V NEI R SN AP GI R+ + +G Sbjct: 326 HEEIDRVIGRNRQPQ-----YEDHMKMPYTQAVINEIQRFSNFAPLGIPRRITKNTSFRG 380 Query: 1174 YTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGIRLCVGA 1353 + +P V ++ +P+ F P FNP + D+ + + F+PF G R C+G Sbjct: 381 FFLPKATEVFPILGSLMTDPKFFSSPKDFNPQHFLDDKGQLKKIPAFLPFSTGKRFCLGD 440 Query: 1354 EFSRIQIALFLHTLVTKYRWKEIKGGEVQRISEIVFPEGYHIQIIPR 1494 +++++ T++ +R+K + +++ I+E PEG+ +IIP+ Sbjct: 441 SLAKMELFFLFTTILQNFRFKFPR--KLEDINESPTPEGF-TRIIPK 484
>O54749:CP2J5_MOUSE Cytochrome P450 2J5 - Mus musculus (Mouse)| Length = 501 Score = 112 bits (281), Expect = 4e-24 Identities = 109/470 (23%), Positives = 210/470 (44%), Gaps = 29/470 (6%) Frame = +1 Query: 172 PPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEVNRF 351 PPG LP VG FQ L + F +K+YG VF L PVVV + + Sbjct: 44 PPGPWRLPFVGNFFQIDTKQTHLVLQQF----VKKYGNVFSLELGQSPVVVVSGLPLIKE 99 Query: 352 IFQQEGKLF-RSWYPDTANNIFGKESIASYDGSFHKYVRSFAS---RLFGLD--SLRDVL 513 +F + F + I GK + +G K R A R FGL SL + + Sbjct: 100 MFTHLDQNFVNRFMTPVRERITGKNGLVVSNGQTWKEQRRLALMALRNFGLGKKSLEERI 159 Query: 514 LAEMDCNVTDSLAAWAAEPA---IEVKDAVANMVFDLTA-----------KKLIGFSPEK 651 E ++ +++ +P +++ +AV+N++ +T ++L+ E Sbjct: 160 QEETH-HLVEAIREEGGQPFNPHLKLINAVSNIICSVTFGERFDYEDCQFQELLQLLDET 218 Query: 652 SRKLRKNFDAFFQGLVSFPLYFPGTTFYRCIQGRKNVQKVLKDLLK--ERLGAPEKRHGD 825 + + + G Y PG + + ++ + ++K E+ P++ D Sbjct: 219 MHLMGSSAGQLYNGFPCIMKYLPGP-HQKIFRNWGKLKLFVSHIVKKHEKDWNPDEPR-D 276 Query: 826 FLDEVVDELQSGRG---VIDEKFAVDLMAALLFASFATVSSSLTIAMKFLSGHPNVVESL 996 F+D + E+Q +E+ + L T SS+L A+ ++S +P + E++ Sbjct: 277 FIDAFLIEMQKDPDRTTSFNEENLISTTLDLFLGGTETTSSTLRWALLYMSSYPEIQENV 336 Query: 997 KEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAP-GIFRKTLTDVQVKG 1173 + E + ++ G K ++ + +SM +T V +E+ R+ N+ P R+ D + G Sbjct: 337 QAEIDRVI-----GHKRQVSLSDRESMPYTNAVIHEVQRMGNIVPLNSSREVTVDTKFNG 391 Query: 1174 YTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGIRLCVGA 1353 + +P G +++ + A+H +P+ + P FNP + E+ + ++F+PF G R C+G Sbjct: 392 FHLPKGTMILTNLTALHRDPKEWATPEVFNPEHFL-ENGQFKKRESFLPFSMGKRACLGE 450 Query: 1354 EFSRIQIALFLHTLVTKYRWKEIKGGEVQ---RISEIVFPEGYHIQIIPR 1494 + ++ ++ +F L+ K+ +K ++ R+ I+ P Y I IPR Sbjct: 451 QLAKSELFIFFSALMQKFTFKPPINEKLSLKFRMGLILSPASYRICAIPR 500
>P11707:CP3A6_RABIT Cytochrome P450 3A6 - Oryctolagus cuniculus (Rabbit)| Length = 501 Score = 112 bits (280), Expect = 5e-24 Identities = 112/449 (24%), Positives = 198/449 (44%), Gaps = 28/449 (6%) Frame = +1 Query: 175 PGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEVNRFI 354 PG LP +G ++ K D+ K+YG ++ QP++V D ++ + + Sbjct: 37 PGPTPLPFIGTILEYRKGIWDFDIEC-----RKKYGKMWGLFDGRQPLMVITDPDMIKTV 91 Query: 355 FQQEG-KLF---RSWYPDTANNIFGKESIASYDGSFHKYVRSFASRLFGLDSLRDVL--L 516 +E +F RS+ P F K++++ + K VR+ S F L+++L + Sbjct: 92 LVKECYSVFTNRRSFGPVG----FMKKAVSISEDEDWKRVRTLLSPTFTSGKLKEMLPII 147 Query: 517 AEMDCNVTDSLAAWAAE-PAIEVKDAVANMVFDLTAKKLIGFSPEKSRKLR----KN--- 672 A+ + +L A + +++K+ D+ G + + R + KN Sbjct: 148 AQYGDVLVKNLRQEAEKGKPVDLKEIFGAYSMDVITGTSFGVNIDSLRNPQDPFVKNVRR 207 Query: 673 ------FDAFFQGLVSFPLYFPGTTFYRCIQGRKNVQKVLKDLLK----ERLGAPEKRHG 822 FD + FP P K+V LK ++ +RL +KR Sbjct: 208 LLKFSFFDPLLLSITLFPFLTPIFEALHISMFPKDVMDFLKTSVEKIKDDRLKDKQKRRV 267 Query: 823 DFLDEVVDELQS----GRGVIDEKFAVDLMAALLFASFATVSSSLTIAMKFLSGHPNVVE 990 DFL +++ S +D+ V +LFA + T SS+L+ M L+ HP+V + Sbjct: 268 DFLQLMINSQNSKEIDSHKALDDIEVVAQSIIILFAGYETTSSTLSFIMHLLATHPDVQQ 327 Query: 991 SLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAPGIFRKTLTDVQVK 1170 L+EE + +L +E T++ M + V NE R+ +A + R DV + Sbjct: 328 KLQEEIDTLLPNKELA-----TYDTLVKMEYLDMVVNETLRLYPIAGRLERVCKKDVDIN 382 Query: 1171 GYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGIRLCVG 1350 G IP G +VM+ A+H +P+ + +P F P R+ ++K + + PFG G R C+G Sbjct: 383 GTFIPKGTIVMMPTYALHRDPQHWTEPDEFRPERFSKKNKDNINPYIYHPFGAGPRNCLG 442 Query: 1351 AEFSRIQIALFLHTLVTKYRWKEIKGGEV 1437 F+ + I L L L+ + +K K +V Sbjct: 443 MRFALMNIKLALVRLMQNFSFKLCKETQV 471
>P08684:CP3A4_HUMAN Cytochrome P450 3A4 - Homo sapiens (Human)| Length = 503 Score = 112 bits (280), Expect = 5e-24 Identities = 112/447 (25%), Positives = 197/447 (44%), Gaps = 26/447 (5%) Frame = +1 Query: 175 PGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEVNRFI 354 PG LP +G + K D+ K+YG V+ QPV+ D ++ + + Sbjct: 39 PGPTPLPFLGNILSYHKGFCMFDMECH-----KKYGKVWGFYDGQQPVLAITDPDMIKTV 93 Query: 355 FQQEG-KLFRSWYPDTANNIFGKESIASYDGSFHKYVRSFASRLFGLDSLRDV--LLAEM 525 +E +F + P F K +I+ + K +RS S F L+++ ++A+ Sbjct: 94 LVKECYSVFTNRRPFGPVG-FMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQY 152 Query: 526 DCNVTDSLAAWAAE-PAIEVKDAVANMVFDLTAKKLIG------------FSPEKSRKLR 666 + +L A + +KD D+ G F + LR Sbjct: 153 GDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLR 212 Query: 667 KNF-DAFFQGLVSFPLYFPGTTFYR-CIQGRKN---VQKVLKDLLKERLGAPEKRHGDFL 831 +F D FF + FP P C+ R+ ++K +K + + RL +K DFL Sbjct: 213 FDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFL 272 Query: 832 DEVVD-----ELQSGRGVIDEKFAVDLMAALLFASFATVSSSLTIAMKFLSGHPNVVESL 996 ++D E +S + + D + + +FA + T SS L+ M L+ HP+V + L Sbjct: 273 QLMIDSQNSKETESHKALSDLELVAQSII-FIFAGYETTSSVLSFIMYELATHPDVQQKL 331 Query: 997 KEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAPGIFRKTLTDVQVKGY 1176 +EE +A+L K+ T++ M + V NE R+ +A + R DV++ G Sbjct: 332 QEEIDAVLPN-----KAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGM 386 Query: 1177 TIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGIRLCVGAE 1356 IP G +VMI A+H +P+ + +P F P R+ ++K + + PFG G R C+G Sbjct: 387 FIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMR 446 Query: 1357 FSRIQIALFLHTLVTKYRWKEIKGGEV 1437 F+ + + L L ++ + +K K ++ Sbjct: 447 FALMNMKLALIRVLQNFSFKPCKETQI 473
>Q7Z449:CP2U1_HUMAN Cytochrome P450 2U1 - Homo sapiens (Human)| Length = 544 Score = 111 bits (278), Expect = 8e-24 Identities = 120/492 (24%), Positives = 211/492 (42%), Gaps = 51/492 (10%) Frame = +1 Query: 85 LCGLAAVVAGWLAHCVYKWTNPACSTGRLPPGSMGLPLVGETFQFFKP------------ 228 LCGL A++ GW W + G +PPG PLVG P Sbjct: 39 LCGLVALL-GW------SWLRRRRARG-IPPGPTPWPLVGNFGHVLLPPFLRRRSWLSSR 90 Query: 229 ------SPSLDVPAFYKQRLKR-YGPVFKTSLVGQPVVVSMDAEVNRFIFQQEGKLFRSW 387 PS+ P L R YG +F + VVV D R Q+ ++F Sbjct: 91 TRAAGIDPSVIGPQVLLAHLARVYGSIFSFFIGHYLVVVLSDFHSVREALVQQAEVFSDR 150 Query: 388 YPDTANNIFGKES--IASYDGSFHKYVRSFAS---RLFGLDSLR---------DVLLAEM 525 +I KE + ++ G + R F+ R FGL L + AEM Sbjct: 151 PRVPLISIVTKEKGVVFAHYGPVWRQQRKFSHSTLRHFGLGKLSLEPKIIEEFKYVKAEM 210 Query: 526 DCNVTDSLAAWAAEPAIEVKDAVANMV--------FDLTA---KKLIGFSPEKSRKLRKN 672 + D ++ + +AV+N++ FD T KK++GF + ++ N Sbjct: 211 QKHGEDPFCPFSI-----ISNAVSNIICSLCFGQRFDYTNSEFKKMLGFM-SRGLEICLN 264 Query: 673 FDAFFQGLVSFPLYFPGTTFYRCIQGRKNVQKVLKDLLKERLGAPEKRHG-DFLDEVVDE 849 + + Y P F Q K++ LK ++K+ + ++ + DF+D + Sbjct: 265 SQVLLVNICPWLYYLPFGPFKELRQIEKDITSFLKKIIKDHQESLDRENPQDFIDMYLLH 324 Query: 850 LQSGR-----GVIDEKFAVDLMAALLFASFATVSSSLTIAMKFLSGHPNVVESLKEEHEA 1014 ++ R DE++ ++ L A T ++SL + ++S +P+V E + EE E Sbjct: 325 MEEERKNNSNSSFDEEYLFYIIGDLFIAGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIER 384 Query: 1015 ILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAP-GIFRKTLTDVQVKGYTIPAG 1191 ++ GA + + M +T E+ R++ V P I T + ++GYTIP G Sbjct: 385 VI-----GANRAPSLTDKAQMPYTEATIMEVQRLTVVVPLAIPHMTSENTVLQGYTIPKG 439 Query: 1192 WLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGIRLCVGAEFSRIQ 1371 L++ + +VH +P ++E P F P R+ D+ + + F+PFG G R+C+G + ++++ Sbjct: 440 TLILPNLWSVHRDPAIWEKPEDFYPNRFLDDQGQLIKKETFIPFGIGKRVCMGEQLAKME 499 Query: 1372 IALFLHTLVTKY 1407 + L +L+ + Sbjct: 500 LFLMFVSLMQSF 511
>P33263:CP2CQ_MESAU Cytochrome P450 2C26 - Mesocricetus auratus (Golden hamster)| Length = 490 Score = 111 bits (278), Expect = 8e-24 Identities = 115/470 (24%), Positives = 204/470 (43%), Gaps = 28/470 (5%) Frame = +1 Query: 97 AAVVAGWLAHCVYKWT--NPACSTGRLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRL 270 A VV ++ C++ + + G+LPPG LP++G Q S + F K Sbjct: 3 AFVVLVFILSCLFLLSLWRQSSERGKLPPGPTPLPIIGNFLQIDVKDISGSLTNFSKV-- 60 Query: 271 KRYGPVFKTSLVGQPVVVSMDAEVNRFIFQQEGKLF--RSWYPDTANNIFGKESIASYDG 444 YGPVF L +P VV E + G+ F R +P A + I +G Sbjct: 61 --YGPVFTLYLGMKPTVVLHGYEAVKEALIDHGEEFAGRGSFP-VAERVNKGLGIVFSNG 117 Query: 445 SFHKYVRSFASRLF-----GLDSLRDVLLAEMDCNVTD--SLAAWAAEPAIEVKDAVANM 603 S K R F+ G S+ D + E C V + +P + A N+ Sbjct: 118 SRWKETRRFSLMTLRNLGMGKRSIEDRVQEEAQCLVEELRKTNGSPCDPTFILGCAPCNV 177 Query: 604 V--------FDLTAKKLIGFSPEKSRKLRKNFDAFFQGLVSFPL---YFPGTTFYRCIQG 750 + FD K + F + + R +FQ +FPL Y PG+ +R + Sbjct: 178 ICSIIFQNRFDYKDKDFLTFMKKLNENARILSSPWFQVCNNFPLLIDYCPGS-HHRITKN 236 Query: 751 RKNVQKVLKDLLKERLGAPEKRHG-DFLDEVVDELQSGRGVIDEKFAVDLMAALLFASFA 927 ++ L + +KE + + + DF+D + +L+ G +F+ + +A + FA Sbjct: 237 INYIRSYLSEKMKEHQESLDVANPRDFIDYYLIKLKQGNYNQQSEFSPENLATTVSDLFA 296 Query: 928 ----TVSSSLTIAMKFLSGHPNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQV 1095 T S++L A+ L HP+V ++EE + ++ G ++ M +T + Sbjct: 297 AGTETTSTTLRYALLLLLKHPHVTAKVQEEIDQVV-----GRHRNPCMQDRSHMPYTDAM 351 Query: 1096 TNEISRVSNVAPGIFRKTLT-DVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWR 1272 +E+ R ++ P +T D++ + Y IP G ++ S +V + + F +P F+P Sbjct: 352 IHEVQRFIDLIPTNLPHAVTCDIKFRDYFIPKGTTIITSLSSVLHDSKEFPNPEVFDPGH 411 Query: 1273 WQDESKKSTMLKNFMPFGGGIRLCVGAEFSRIQIALFLHTLVTKYRWKEI 1422 + D++ FMPF G R+C G +R+++ LFL T++ ++ K + Sbjct: 412 FLDKNGNFKKSDYFMPFSTGKRMCAGEGLARMELFLFLTTILQNFKLKSL 461
>P11711:CP2A1_RAT Cytochrome P450 2A1 - Rattus norvegicus (Rat)| Length = 492 Score = 111 bits (278), Expect = 8e-24 Identities = 119/473 (25%), Positives = 200/473 (42%), Gaps = 29/473 (6%) Frame = +1 Query: 163 GRLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAE- 339 GRLPPG LP +G Q + DV + Q +RYGPVF L + VVV + Sbjct: 30 GRLPPGPTPLPFIGNYLQL----NTKDVYSSITQLSERYGPVFTIHLGPRRVVVLYGYDA 85 Query: 340 VNRFIFQQEGKLFRSWYPDTANNIFGKESIASYDGSFHKYVRSFAS---RLFGLDS--LR 504 V + Q + T N +F +A G K +R + R FG+ + Sbjct: 86 VKEALVDQAEEFSGRGEQATYNTLFKGYGVAFSSGERAKQLRRLSIATLRDFGVGKRGVE 145 Query: 505 DVLLAEMD--CNVTDSLAAWAAEPAIEVKDAVANMVF-----------DLTAKKLIGFSP 645 + +L E + +P I + V+N++ D L+ Sbjct: 146 ERILEEAGYLIKMLQGTCGAPIDPTIYLSKTVSNVISSIVFGERFDYEDTEFLSLLQMMG 205 Query: 646 EKSRKLRKNFDAFFQGLVSFPLYFPGTTFYRCIQGRKNVQKVLKDLLKERL--------- 798 + +R + S Y PG Q V + L+D + E++ Sbjct: 206 QMNRFAASPTGQLYDMFHSVMKYLPGPQ-----QQIIKVTQKLEDFMIEKVRQNHSTLDP 260 Query: 799 GAPEKRHGDFLDEVVDELQSGRGVIDEKFAVDLMAALLFASFATVSSSLTIAMKFLSGHP 978 +P FL + +E ++G K V +L FA TVSS+L L HP Sbjct: 261 NSPRNFIDSFLIRMQEE-KNGNSEFHMKNLVMTTLSLFFAGSETVSSTLRYGFLLLMKHP 319 Query: 979 NVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAP-GIFRKTLT 1155 +V + EE E ++ + + +E++ M +T V NEI R SN+AP GI R+ + Sbjct: 320 DVEAKVHEEIEQVIGRNRQPQ-----YEDHMKMPYTQAVINEIQRFSNLAPLGIPRRIIK 374 Query: 1156 DVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGI 1335 + +G+ +P G V ++ +P+ F P F+P + D+ + F+PF G Sbjct: 375 NTTFRGFFLPKGTDVFPILGSLMTDPKFFPSPKDFDPQNFLDDKGQLKKNAAFLPFSTGK 434 Query: 1336 RLCVGAEFSRIQIALFLHTLVTKYRWKEIKGGEVQRISEIVFPEGYHIQIIPR 1494 R C+G +++++ L L T++ +R+K +++ I+E P G+ +IIP+ Sbjct: 435 RFCLGDGLAKMELFLLLTTILQNFRFKFPM--KLEDINESPKPLGF-TRIIPK 484
>P33264:CP2CR_MESAU Cytochrome P450 2C27 - Mesocricetus auratus (Golden hamster)| Length = 490 Score = 111 bits (277), Expect = 1e-23 Identities = 115/470 (24%), Positives = 206/470 (43%), Gaps = 28/470 (5%) Frame = +1 Query: 97 AAVVAGWLAHCVYKWT--NPACSTGRLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRL 270 A VV ++ C++ + + G+LPPG LPL+G FQ S + F K Sbjct: 3 AFVVLVFILSCLFLLSLWRQSSERGKLPPGPTPLPLIGNFFQIDVKDISGSLTNFSKV-- 60 Query: 271 KRYGPVFKTSLVGQPVVVSMDAEVNRFIFQQEGKLF--RSWYPDTANNIFGKESIASYDG 444 YGPVF L +P VV E + G+ F R +P G + S +G Sbjct: 61 --YGPVFTLYLGRKPAVVLHGYEAVKEALIDHGEEFAGRGSFPMAERYNKGLGIVFS-NG 117 Query: 445 SFHKYVRSFA-----SRLFGLDSLRDVLLAEMDCNVTD--SLAAWAAEPAIEVKDAVANM 603 + K +R F+ S G S+ D + E C V + +P + A N+ Sbjct: 118 NRWKDIRRFSLMALRSLGMGKRSIEDRVQEEAQCLVEELRKTNGSPCDPTFILSCAPCNV 177 Query: 604 V--------FDLTAKKLIGFSPEKSRKLRKNFDAFFQGLVSFPL---YFPGTTFYRCIQG 750 + FD T + + F + + +R + Q +FP Y PG+ + + Sbjct: 178 ICSIIFQNRFDYTDQDFLTFMEKVNENVRILSSPWLQVCNNFPSLIDYCPGS-HHTITKN 236 Query: 751 RKNVQKVLKDLLKERLGAPEKRHG-DFLDEVVDELQSGRGVIDEKFAVDLMAALLFASFA 927 ++ L + +KE + + DF+D + +L+ G +F ++ +A + FA Sbjct: 237 VNYIRSYLSEKIKEHQETLDVANPRDFIDYYLIKLKQGNYNQQSEFTLENLATTVRDLFA 296 Query: 928 ----TVSSSLTIAMKFLSGHPNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQV 1095 T S++L A+ L HP+V ++EE + ++ G ++ M +T + Sbjct: 297 AGTETTSTTLRYALLLLLKHPHVTAKVQEEIDQVV-----GRHRNPCMQDRSHMPYTDAM 351 Query: 1096 TNEISRVSNVAPGIFRKTLT-DVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWR 1272 +E+ R ++ P +T D++ + Y IP G ++ S +V + + F +P F+P Sbjct: 352 IHEVQRFIDLIPTNLPHAVTCDIKFRDYFIPKGTTIITSLSSVLHDSKEFPNPEVFDPGH 411 Query: 1273 WQDESKKSTMLKNFMPFGGGIRLCVGAEFSRIQIALFLHTLVTKYRWKEI 1422 + D++ K FMPF G R+C G +R+++ LFL T++ ++ K + Sbjct: 412 FLDKNGKFKKSDYFMPFSTGKRMCAGEGLARMELFLFLTTILQNFKLKSL 461
>P79102:CP3AS_BOVIN Cytochrome P450 3A28 - Bos taurus (Bovine)| Length = 507 Score = 110 bits (274), Expect = 2e-23 Identities = 107/451 (23%), Positives = 190/451 (42%), Gaps = 30/451 (6%) Frame = +1 Query: 175 PGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEVNRFI 354 PG +P G T + K +P F Q K+YG ++ QP++ D ++ + + Sbjct: 39 PGPRPVPYFGSTMAYHK-----GIPEFDNQCFKKYGKMWGFYEGRQPMLAITDPDIIKTV 93 Query: 355 FQQEGKLFRSWYPDTANNIFGKESIASYDGSFH-----KYVRSFASRLFGLDSLRDV--L 513 +E + T IFG I Y S K +R+ S F L+++ + Sbjct: 94 LVKE-----CYSVFTNRRIFGPMGIMKYAISLAWDEQWKRIRTLLSPAFTSGKLKEMFPI 148 Query: 514 LAEMDCNVTDSLAAWAAEP-AIEVKDAVANMVFDLTAKKLIGFS-----------PEKSR 657 + + + +L A + + +KD D+ G + E S+ Sbjct: 149 IGQYGDMLVRNLRKEAEKGNPVNMKDMFGAYSMDVITGTAFGVNIDSLNNPHDPFVEHSK 208 Query: 658 KLRK--NFDAFFQGLVSFPLYFPGTTFYRCIQGRKNV----QKVLKDLLKERLGAPEKRH 819 L + FD F ++ FP P K+ K +K + + RL + Sbjct: 209 NLLRFRPFDPFILSIILFPFLNPVFEILNITLFPKSTVDFFTKSVKKIKESRLTDKQMNR 268 Query: 820 GDFLDEVVDELQSGRGVIDEKFAVDL-----MAALLFASFATVSSSLTIAMKFLSGHPNV 984 D L +++ Q+ + + + K D+ +F + T SS+L+ + L+ HP+V Sbjct: 269 VDLLQLMINS-QNSKEIDNHKALSDIELVAQSTIFIFGGYETTSSTLSFIIYELTTHPHV 327 Query: 985 VESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAPGIFRKTLTDVQ 1164 + L+EE +A K+ T++ M + V NE R+ +A + R DV+ Sbjct: 328 QQKLQEEIDATFPN-----KAPPTYDALVQMEYLDMVVNETLRMFPIAGRLERVCKKDVE 382 Query: 1165 VKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGIRLC 1344 + G TIP G V++ +H NPEL+ +P F P R+ +K S ++PFG G R C Sbjct: 383 IHGVTIPKGTTVLVPLFVLHNNPELWPEPEEFRPERFSKNNKDSINPYVYLPFGTGPRNC 442 Query: 1345 VGAEFSRIQIALFLHTLVTKYRWKEIKGGEV 1437 +G F+ + I L L ++ + +K K ++ Sbjct: 443 LGMRFAIMNIKLALVRILQNFSFKPCKETQI 473
>P05183:CP3A2_RAT Cytochrome P450 3A2 - Rattus norvegicus (Rat)| Length = 504 Score = 110 bits (274), Expect = 2e-23 Identities = 105/449 (23%), Positives = 194/449 (43%), Gaps = 28/449 (6%) Frame = +1 Query: 175 PGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEVNRFI 354 PG LP +G ++K D+ + K+YG ++ PV MD E+ + + Sbjct: 39 PGPKPLPFLGTVLNYYKGLGRFDMECY-----KKYGKIWGLFDGQTPVFAIMDTEMIKNV 93 Query: 355 FQQEG-KLFRSWYPDTANNIFGKESIASYDGSFHKYVRSFASRLFGLDSLRDVLLAEMDC 531 +E +F + I GK + D + +Y R+ S F L+++ + Sbjct: 94 LVKECFSVFTNRRDFGPVGIMGKAVSVAKDEEWKRY-RALLSPTFTSGRLKEMF--PIIE 150 Query: 532 NVTDSLAAWAAEPAIEVKDAVANMVFDLTAKKLIGFSP----------------EKSRKL 663 D L + + A K VF + +I + EK++KL Sbjct: 151 QYGDILVKYLKQEAETGKPVTMKKVFGAYSMDVITSTSFGVNVDSLNNPKDPFVEKTKKL 210 Query: 664 RKN--FDAFFQGLVSFPLYFPGTTFYR-CIQGRKNV---QKVLKDLLKERLGAPEKRHGD 825 + FD F +V FP P C+ + ++ QK + + + RL + K D Sbjct: 211 LRFDFFDPLFLSVVLFPFLTPIYEMLNICMFPKDSIAFFQKFVHRIKETRLDSKHKHRVD 270 Query: 826 FLDEVVDELQSGRGVIDEKFAVDL-----MAALLFASFATVSSSLTIAMKFLSGHPNVVE 990 FL +++ + + + K D+ +FA + T SS+L+ + FL+ HP++ + Sbjct: 271 FLQLMLNAHNNSKDEVSHKALSDVEIIAQSVIFIFAGYETTSSTLSFVLYFLATHPDIQK 330 Query: 991 SLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAPGIFRKTLTDVQVK 1170 L+EE + L +K+ T++ M + V NE R+ + + R D+++ Sbjct: 331 KLQEEIDGALP-----SKAPPTYDIVMEMEYLDMVLNETLRLYPIGNRLERVCKKDIELD 385 Query: 1171 GYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGIRLCVG 1350 G IP G +V I A+H +P+ + P F+P R+ E+K S ++PFG G R C+G Sbjct: 386 GLFIPKGSVVTIPTYALHHDPQHWPKPEEFHPERFSKENKGSIDPYVYLPFGNGPRNCIG 445 Query: 1351 AEFSRIQIALFLHTLVTKYRWKEIKGGEV 1437 F+ + + L L ++ + ++ K ++ Sbjct: 446 MRFALMNMKLALTKVLQNFSFQPCKETQI 474
>O18993:CP3AL_CALJA Cytochrome P450 3A21 - Callithrix jacchus (Common marmoset)| Length = 503 Score = 109 bits (273), Expect = 3e-23 Identities = 118/477 (24%), Positives = 206/477 (43%), Gaps = 35/477 (7%) Frame = +1 Query: 175 PGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEVNRFI 354 PG LP +G + + D+ + K+YG ++ QPV+ D + + + Sbjct: 39 PGPTPLPFLGTVLYYRQGFWKFDMECY-----KKYGKMWGIYDGRQPVLAITDPNIIKTV 93 Query: 355 FQQEG-KLFRSWYPDTANNIFGKESIASYDGSFHKYVRSFASRLFGLDSLRDV--LLAEM 525 +E +F + P F K +I+ K +RS S F L+++ ++A+ Sbjct: 94 LVKECYSVFTNRRPFGPVG-FMKSAISIAQDDEWKRIRSLLSPTFTSGKLKEMVPIIAQY 152 Query: 526 DCNVTDSLAAWAAE-PAIEVKDAVANMVFDLTAKKLIG------------FSPEKSRKLR 666 + +L A + I +KD D+ G F + LR Sbjct: 153 GEVLVRNLRREAEKGKPINMKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKLLR 212 Query: 667 KNF-DAFFQGLVSFPLYFPGTTFYRCIQGRKN----VQKVLKDLLKERLGAPEKRHGDFL 831 +F D FF + FP P ++ ++K +K + + RL K DFL Sbjct: 213 FDFLDPFFLSITIFPFLTPILEALNISMFPRDSTSFLRKSIKRIKESRLKDTHKHRVDFL 272 Query: 832 DEVVDELQSGRGVIDEKFA-VDLMAA---LLFASFATVSSSLTIAMKFLSGHPNVVESLK 999 ++D S D+ + ++L+A +FA + T SS+L+ M L+ HP+V + L+ Sbjct: 273 QLMIDSQNSKETESDKALSDLELVAQSIIFIFAGYETTSSTLSFIMYELATHPDVQQKLQ 332 Query: 1000 EEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAPGIFRKTLTDVQVKGYT 1179 EE +A+L K+ T++ M + V NE R+ +A + R DV++ G Sbjct: 333 EEIDAVLPN-----KAPATYDTVLQMEYLDMVVNETLRLFPLAMRLERVCKKDVEINGVF 387 Query: 1180 IPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGIRLCVGAEF 1359 IP G +VMI A+H +P+ + +P F P R+ +K + + PFG G R C+G F Sbjct: 388 IPKGVVVMIPSYALHYDPKYWTEPEKFLPERFSKNNKDNIDPYIYTPFGTGPRNCIGMRF 447 Query: 1360 SRIQIALFLHTLVTKYRWKEIK----------GGEVQRISEIVFPEGYHIQIIPREG 1500 + + + L L ++ + +K K GG +Q IV +++ PR+G Sbjct: 448 ALMNMKLALIRVLQNFSFKPCKETQIPLKLRLGGLLQTEKPIV------LKVEPRDG 498
>P24455:CP2A9_MESAU Cytochrome P450 2A9 - Mesocricetus auratus (Golden hamster)| Length = 493 Score = 109 bits (272), Expect = 4e-23 Identities = 121/484 (25%), Positives = 205/484 (42%), Gaps = 40/484 (8%) Frame = +1 Query: 163 GRLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVV--SMDA 336 G+LPPG LP +G Q + D+ + + +RYGPVF L +PVVV DA Sbjct: 30 GKLPPGPTPLPYIGNYLQL----NTKDIYSSITELSERYGPVFTIYLGPRPVVVLYGYDA 85 Query: 337 EVNRFIFQQEGKLFRSWYPDTANNIFGKESIASYDGSFHKYVRSFAS-------RLFGLD 495 + D A G+ A+Y+ F Y +F+S R F + Sbjct: 86 VKEALV-------------DQAEEFSGRGEQATYNTLFKDYGVAFSSGERAKQLRRFSIA 132 Query: 496 SLRDVLLAEMDCNVTDSLAAWAA--------------EPAIEVKDAVANMV--------F 609 +LRD + + V + + AA +P + V+N++ F Sbjct: 133 TLRDFGVGKR--GVEERIQEEAAYLIKMLRSTRGAPIDPNDYLSQTVSNVISSVVFGDAF 190 Query: 610 DLTAKK---LIGFSPEKSRKLRKNFDAFFQGLVSFPLYFPGTTFYRCIQGRKNVQKVLKD 780 D K+ L+ E ++ + S Y PG + I+ K ++ + Sbjct: 191 DYEDKEFLELLHMMNEMNKFAASPVGQLYDMFHSVMKYLPGPQ-QQIIKNTKELEDFMIR 249 Query: 781 LLKER-----LGAPEKRHGDFLDEVVDELQSGRGVIDEKFAVDLMAALLFASFATVSSSL 945 +K+ L + FL + +E ++ + K V L FA TVSS++ Sbjct: 250 KVKQNQSTLDLNSARNFIDSFLIHMHEEKKNPTSEFNIKNLVMTSLNLFFAGSETVSSTI 309 Query: 946 TIAMKFLSGHPNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNV 1125 L +P V + EE + ++ + + +E+ M +T V NEI R +N+ Sbjct: 310 RYGFLLLMKYPEVEAKVHEEIDRVIGRNRQPQ-----FEDRMKMPYTEAVINEIQRFANL 364 Query: 1126 AP-GIFRKTLTDVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTM 1302 AP GI RKT+ + +G+ +P V ++ +P+ F P FNP + D+ + Sbjct: 365 APLGIPRKTIKNTTFRGFFLPKDTDVYPILGSLLTDPKFFTSPKHFNPQNFLDDRGQLKK 424 Query: 1303 LKNFMPFGGGIRLCVGAEFSRIQIALFLHTLVTKYRWKEIKGGEVQRISEIVFPEGYHIQ 1482 + F+PF G R C+G +R+++ LFL T++ +R K K +++ I P G+ + Sbjct: 425 IAAFVPFSVGKRFCLGDGLARMELFLFLTTILQNFRLKFPK--KLEDIDASPKPLGFS-R 481 Query: 1483 IIPR 1494 IIPR Sbjct: 482 IIPR 485
>Q9HB55:CP343_HUMAN Cytochrome P450 3A43 - Homo sapiens (Human)| Length = 503 Score = 108 bits (271), Expect = 5e-23 Identities = 107/447 (23%), Positives = 195/447 (43%), Gaps = 26/447 (5%) Frame = +1 Query: 175 PGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEVNRFI 354 PG LP +G + + + D ++ ++YG ++ QP++V MD ++ + + Sbjct: 39 PGPTPLPFLGTILFYLRGLWNFD-----RECNEKYGEMWGLYEGQQPMLVIMDPDMIKTV 93 Query: 355 FQQEG-KLFRSWYPDTANNIFGKESIASYDGSFHKYVRSFASRLFGLDSLRDVLLAEMDC 531 +E +F + P F K +++ + K +R+ S F ++++ C Sbjct: 94 LVKECYSVFTNQMPLGPMG-FLKSALSFAEDEEWKRIRTLLSPAFTSVKFKEMVPIISQC 152 Query: 532 N--VTDSLAAWAAEP-AIEVKDAVANMVFDLTAKKLIG------------FSPEKSRKLR 666 + SL A +I +KD D+ L G F + L+ Sbjct: 153 GDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFGVNLDSLNNPQDPFLKNMKKLLK 212 Query: 667 KNF-DAFFQGLVSFPLYFPGTTFYRCIQGRKNVQKVLKDLLKE----RLGAPEKRHGDFL 831 +F D F + FP P K+V LK+ ++ RL +K DF Sbjct: 213 LDFLDPFLLLISLFPFLTPVFEALNIGLFPKDVTHFLKNSIERMKESRLKDKQKHRVDFF 272 Query: 832 DEVVDELQSGRGVIDEKFAVDLMAA-----LLFASFATVSSSLTIAMKFLSGHPNVVESL 996 +++D Q+ + K DL ++FA++ T S++L M L+ HP+V + L Sbjct: 273 QQMIDS-QNSKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKL 331 Query: 997 KEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAPGIFRKTLTDVQVKGY 1176 +EE +A+L K+ +T++ M + V NE R+ V + R D+++ G Sbjct: 332 QEEIDAVLPN-----KAPVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGV 386 Query: 1177 TIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGIRLCVGAE 1356 IP G VM+ A+H +P+ + +P F P R+ ++K S L ++PFG G R C+G Sbjct: 387 FIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFSKKNKDSIDLYRYIPFGAGPRNCIGMR 446 Query: 1357 FSRIQIALFLHTLVTKYRWKEIKGGEV 1437 F+ I L + + + +K K ++ Sbjct: 447 FALTNIKLAVIRALQNFSFKPCKETQI 473
>P15123:CP2CG_RABIT Cytochrome P450 2C16 - Oryctolagus cuniculus (Rabbit)| Length = 487 Score = 108 bits (271), Expect = 5e-23 Identities = 112/448 (25%), Positives = 190/448 (42%), Gaps = 28/448 (6%) Frame = +1 Query: 163 GRLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEV 342 G+LPPG P++G Q S + F + RYGPVF L +P VV + Sbjct: 27 GKLPPGPTPFPIIGNILQIDAKDISKSLTKFSE----RYGPVFTVYLGMKPAVVLHGYQA 82 Query: 343 NRFIFQQEGKLF--RSWYPDTANNIFGKESIASYDGSFHKYVRSFAS---RLFGLD--SL 501 + G+ F R +P + + I +G K +R F+ R FG+ S+ Sbjct: 83 VKEALVDLGEEFAGRGSFP-MLDKVSKGLGIVFTNGKRWKEIRRFSLMTLRNFGMGKRSI 141 Query: 502 RDVLLAEMDCNVTD--SLAAWAAEPAIEVKDAVANMVFDLTAKKLIGFSPEKSRKLRKNF 675 D + E C V + A +P + A N++ + + E+ KL + F Sbjct: 142 EDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICSIIFHNRFDYKDEEFLKLLEKF 201 Query: 676 DAFFQGLVSFPLYFPGTTFYRCIQGRKNVQKVL---KDLLKERLGAPEKRHGDFLDEVVD 846 + + ++S P F I K L D +K + K H FLD Sbjct: 202 NENVR-ILSSPWLQVCNNFPALIDYLPGSHKTLLKNSDYVKNFIMEKVKEHQKFLD---- 256 Query: 847 ELQSGRGVID-----------EKFAVDLMAALLFASFA----TVSSSLTIAMKFLSGHPN 981 + + R ID +F ++ + +F F T S++L ++ L HP Sbjct: 257 -VNNPRDFIDCFLIKMEQENHLEFTLESLVTTVFDLFGAGTETTSTTLRYSLLLLLKHPE 315 Query: 982 VVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAPGIFRKTLT-D 1158 V + ++EE E ++ G ++ M +T V +EI R ++ P T+T D Sbjct: 316 VADKVQEEIERVI-----GRHRSPCMQDRSRMPYTDAVIHEIQRFIDLVPNNLPHTVTRD 370 Query: 1159 VQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGIR 1338 ++ + Y IP G +M S +V + + F +P F+P + DES FMPF G R Sbjct: 371 IKFRNYFIPKGTDIMTSLTSVLHDEKAFPNPKVFDPGHFLDESGNFKKSDYFMPFSAGKR 430 Query: 1339 LCVGAEFSRIQIALFLHTLVTKYRWKEI 1422 +CVG +R+++ LFL +++ ++ + + Sbjct: 431 ICVGEALARMELFLFLTSILQNFKLQSL 458
>P15149:CP2A2_RAT Cytochrome P450 2A2 - Rattus norvegicus (Rat)| Length = 492 Score = 108 bits (270), Expect = 7e-23 Identities = 118/466 (25%), Positives = 205/466 (43%), Gaps = 24/466 (5%) Frame = +1 Query: 166 RLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVV--SMDAE 339 RLPPG LP +G Q DV + Q +RYGPVF L + +VV DA Sbjct: 31 RLPPGPTPLPFIGNYLQLNMK----DVYSSITQLSERYGPVFTIHLGPRRIVVLYGYDAV 86 Query: 340 VNRFIFQQEGKLFRSWYPDTANNIFGKESIASYDGSFHKYVRSFAS---RLFGLDS--LR 504 + Q E R P T N +F + + K +R F R FG+ ++ Sbjct: 87 KEALVDQAEEFSGRGELP-TFNILFKGYGFSLSNVEQAKRIRRFTIATLRDFGVGKRDVQ 145 Query: 505 DVLLAEMDCNVTDSLAAWAA--EPAIEVKDAVANMVFDLTAKKLIGFSPEKSRKLRKNFD 678 + +L E + A +P+I + V+N++ + + ++ L + D Sbjct: 146 ECILEEAGYLIKTLQGTCGAPIDPSIYLSKTVSNVINSIVFGNRFDYEDKEFLSLLEMID 205 Query: 679 AF--FQGLVSFPLYFPGTTFYRCIQG-RKNVQKVLKDLLKERLGAPEKRHG--------D 825 F + LY + + + G ++ + KV + L + + H + Sbjct: 206 EMNIFAASATGQLYDMFHSVMKYLPGPQQQIIKVTQKLEDFMIEKVRQNHSTLDPNSPRN 265 Query: 826 FLDEVVDELQSGRGVIDEKFAVDLMAA---LLFASFATVSSSLTIAMKFLSGHPNVVESL 996 F+D + +Q + V E +L+ + LLFA +VSS+L L HP+V + Sbjct: 266 FIDSFLIRMQEEKYVNSEFHMNNLVMSSLGLLFAGTGSVSSTLYHGFLLLMKHPDVEAKV 325 Query: 997 KEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAP-GIFRKTLTDVQVKG 1173 EE E ++ + + +E++ M +T V NEI R SN+AP GI R+ + + +G Sbjct: 326 HEEIERVIGRNRQPQ-----YEDHMKMPYTQAVINEIQRFSNLAPLGIPRRIIKNTTFRG 380 Query: 1174 YTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGIRLCVGA 1353 + +P G V ++ P+ F + FNP + D+ + F+PF G R C+G Sbjct: 381 FFLPKGTDVFPIIGSLMTEPKFFPNHKDFNPQHFLDDKGQLKKNAAFLPFSIGKRFCLGD 440 Query: 1354 EFSRIQIALFLHTLVTKYRWKEIKGGEVQRISEIVFPEGYHIQIIP 1491 +++++ L L T++ +R+K ++ I+E P G+ +IIP Sbjct: 441 SLAKMELFLLLTTILQNFRFKFPM--NLEDINEYPSPIGF-TRIIP 483
>O70537:CP3AV_MESAU Cytochrome P450 3A31 - Mesocricetus auratus (Golden hamster)| Length = 501 Score = 107 bits (268), Expect = 1e-22 Identities = 105/451 (23%), Positives = 188/451 (41%), Gaps = 30/451 (6%) Frame = +1 Query: 175 PGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEVNRFI 354 PG LP +G ++K + D+ K+YG ++ +P+ D E+ + + Sbjct: 39 PGPKPLPFLGNVLNYYKGIWTFDIECH-----KKYGKIWGLFEGQRPLFTVTDTEMIKNV 93 Query: 355 FQQEG-KLFRSWYPDTANNIFGKESIASYDGSFHKYVRSFASRLFGLDSLRDVL-LAEMD 528 +E +F + I K S D + K +R+ S F L+++ + E Sbjct: 94 LVKECYSIFTNRRDFGPVGIMSKAVSISKDEEW-KRIRALLSPTFTSGKLKEMFPIIEQY 152 Query: 529 CNVTDSLAAWAAEPA--IEVKDAVANMVFDLTAKKLIGFSPE----------KSRKLRKN 672 ++ AE + K+ D+ G S + K RKL + Sbjct: 153 GDILVKFLRREAEKGNPVTTKEVFGAYSMDVITSTAFGVSVDSLNNPKDLLWKGRKLLRF 212 Query: 673 --FDAFFQGLVSFPLYFPGTTFYRCIQGRKNVQKVLKDLL-----------KERLGAPEK 813 FD F +V FP P I + NV KD + + RL +K Sbjct: 213 DFFDPLFLSVVLFPFLIP-------IYEKLNVSMFPKDSISFFRKFVDKTKENRLDYNQK 265 Query: 814 RHGDFLDEVV---DELQSGRGVIDEKFAVDLMAALLFASFATVSSSLTIAMKFLSGHPNV 984 DFL ++ D + + + + +FA + T SS+L+ A+ L+ HP+V Sbjct: 266 HRVDFLQLMMNSHDNSKDSHKALSDMEIIAQSIIFIFAGYDTTSSTLSFALYLLATHPDV 325 Query: 985 VESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAPGIFRKTLTDVQ 1164 + L+EE + L K+ ++++ M + V NE R+ + + R DV+ Sbjct: 326 QKKLQEEIDIALPN-----KARPSYDKVMEMEYLDMVLNETLRLYPIGSRLERVCKQDVE 380 Query: 1165 VKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGIRLC 1344 + G +P G +VM+ A+H +P+ + +P F P R+ E+K S F+PFG G R C Sbjct: 381 MDGVFVPKGSIVMVPVFALHYDPQYWPEPEKFRPERFSKENKGSIDPYIFLPFGNGPRNC 440 Query: 1345 VGAEFSRIQIALFLHTLVTKYRWKEIKGGEV 1437 +G F+ + + L L ++ + + K ++ Sbjct: 441 IGMRFALMNMKLALTKVLQNFSLQPCKETQI 471
>P33261:CP2CJ_HUMAN Cytochrome P450 2C19 - Homo sapiens (Human)| Length = 490 Score = 107 bits (268), Expect = 1e-22 Identities = 115/448 (25%), Positives = 198/448 (44%), Gaps = 28/448 (6%) Frame = +1 Query: 163 GRLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEV 342 G+LPPG LP++G Q DV K YGPVF + +VV EV Sbjct: 27 GKLPPGPTPLPVIGNILQI----DIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEV 82 Query: 343 NRFIFQQEGKLF--RSWYP--DTANNIFGKESIASYDGSFHKYVRSFAS---RLFGLD-- 495 + G+ F R +P + AN FG I +G K +R F+ R FG+ Sbjct: 83 VKEALIDLGEEFSGRGHFPLAERANRGFG---IVFSNGKRWKEIRRFSLMTLRNFGMGKR 139 Query: 496 SLRDVLLAEMDCNVTD--SLAAWAAEPAIEVKDAVANMVFDLTAKKLIGFSPEK----SR 657 S+ D + E C V + A +P + A N++ + +K + ++ Sbjct: 140 SIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLME 199 Query: 658 KLRKNF----DAFFQGLVSFPL---YFPGTTFYRCIQGRKNVQKVLKDLLKERLGAPEKR 816 KL +N + Q +FP YFPGT + ++ ++ + + +KE + + Sbjct: 200 KLNENIRIVSTPWIQICNNFPTIIDYFPGT-HNKLLKNLAFMESDILEKVKEHQESMDIN 258 Query: 817 HG-DFLDEVVDELQSGRGVIDEKFAVDLM----AALLFASFATVSSSLTIAMKFLSGHPN 981 + DF+D + +++ + +F ++ + A LL A T S++L A+ L HP Sbjct: 259 NPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPE 318 Query: 982 VVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAPGIFRKTLT-D 1158 V ++EE E ++ G ++ M +T V +E+ R ++ P +T D Sbjct: 319 VTAKVQEEIERVV-----GRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCD 373 Query: 1159 VQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGIR 1338 V+ + Y IP G ++ S +V + + F +P F+P + DE FMPF G R Sbjct: 374 VKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKR 433 Query: 1339 LCVGAEFSRIQIALFLHTLVTKYRWKEI 1422 +CVG +R+++ LFL ++ + K + Sbjct: 434 ICVGEGLARMELFLFLTFILQNFNLKSL 461
>P11712:CP2C9_HUMAN Cytochrome P450 2C9 - Homo sapiens (Human)| Length = 490 Score = 107 bits (268), Expect = 1e-22 Identities = 110/448 (24%), Positives = 195/448 (43%), Gaps = 28/448 (6%) Frame = +1 Query: 163 GRLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEV 342 G+LPPG LP++G Q D+ K YGPVF +P+VV E Sbjct: 27 GKLPPGPTPLPVIGNILQI----GIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGYEA 82 Query: 343 NRFIFQQEGKLF--RSWYP--DTANNIFGKESIASYDGSFHKYVRSFAS---RLFGLD-- 495 + G+ F R +P + AN FG I +G K +R F+ R FG+ Sbjct: 83 VKEALIDLGEEFSGRGIFPLAERANRGFG---IVFSNGKKWKEIRRFSLMTLRNFGMGKR 139 Query: 496 SLRDVLLAEMDCNVTD--SLAAWAAEPAIEVKDAVANMVFDLTAKKLIGFSPEK----SR 657 S+ D + E C V + A +P + A N++ + K + ++ Sbjct: 140 SIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLME 199 Query: 658 KLRKNFDAFFQGLVSF-----PL--YFPGTTFYRCIQGRKNVQKVLKDLLKERLGAPEKR 816 KL +N + P+ YFPGT + ++ ++ + + +KE + + Sbjct: 200 KLNENIKILSSPWIQICNNFSPIIDYFPGT-HNKLLKNVAFMKSYILEKVKEHQESMDMN 258 Query: 817 HG-DFLDEVVDELQSGRGVIDEKFAVDLM----AALLFASFATVSSSLTIAMKFLSGHPN 981 + DF+D + +++ + +F ++ + L A T S++L A+ L HP Sbjct: 259 NPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPE 318 Query: 982 VVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAPGIFRKTLT-D 1158 V ++EE E ++ G ++ M +T V +E+ R ++ P +T D Sbjct: 319 VTAKVQEEIERVI-----GRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCD 373 Query: 1159 VQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGIR 1338 ++ + Y IP G ++IS +V + + F +P F+P + DE K FMPF G R Sbjct: 374 IKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKR 433 Query: 1339 LCVGAEFSRIQIALFLHTLVTKYRWKEI 1422 +CVG + +++ LFL +++ + K + Sbjct: 434 ICVGEALAGMELFLFLTSILQNFNLKSL 461
>P33268:CP3A8_MACFA Cytochrome P450 3A8 - Macaca fascicularis (Crab eating macaque)| (Cynomolgus monkey) Length = 503 Score = 107 bits (267), Expect = 2e-22 Identities = 108/447 (24%), Positives = 194/447 (43%), Gaps = 26/447 (5%) Frame = +1 Query: 175 PGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEVNRFI 354 PG LPL+G + K + D+ + K+YG V+ QPV+ D + + + Sbjct: 39 PGPTPLPLLGNILSYRKGFWTFDMECY-----KKYGKVWGFYDGRQPVLAITDPNMIKTV 93 Query: 355 FQQEG-KLFRSWYPDTANNIFGKESIASYDGSFHKYVRSFASRLFGLDSLRDV--LLAEM 525 +E +F + P F K +I+ + K +RS S F L+++ ++A+ Sbjct: 94 LVKECYSVFTNRRPFGPVG-FMKNAISIAEDEEWKRIRSLLSPTFTSGKLKEMVPIIAKY 152 Query: 526 DCNVTDSLAAWAAE-PAIEVKDAVANMVFDLTAKKLIG------------FSPEKSRKLR 666 + +L A + +KD D+ G F + LR Sbjct: 153 GDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLR 212 Query: 667 KNF-DAFFQGLVSFPLYFPGTTFYRCIQGRKNV----QKVLKDLLKERLGAPEKRHGDFL 831 +F D FF + FP P + V +K +K + + RL +K DFL Sbjct: 213 FDFLDPFFLSITIFPFIIPILEVLNISIFPREVTSFLRKSVKRIKESRLKDTQKHRVDFL 272 Query: 832 DEVVD-----ELQSGRGVIDEKFAVDLMAALLFASFATVSSSLTIAMKFLSGHPNVVESL 996 ++D E +S + + D + + +FA + T SS L+ + L+ HP+V + L Sbjct: 273 QLMIDSQNSKETESHKALSDLELVAQSII-FIFAGYETTSSVLSFIIYELATHPDVQQKL 331 Query: 997 KEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAPGIFRKTLTDVQVKGY 1176 +EE + +L K+ T++ M + V NE R+ +A + R DV++ G Sbjct: 332 QEEIDTVLPN-----KAPPTYDTVLQMEYLDMVVNETLRIFPIAMRLERVCKKDVEINGI 386 Query: 1177 TIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGIRLCVGAE 1356 IP G +VMI A+H +P+ + +P F P R+ ++ + + PFG G R C+G Sbjct: 387 FIPKGVVVMIPSYALHHDPKYWPEPEKFLPERFSKKNNDNIDPYIYTPFGSGPRNCIGMR 446 Query: 1357 FSRIQIALFLHTLVTKYRWKEIKGGEV 1437 F+ + + L + ++ + +K K ++ Sbjct: 447 FALMNMKLAIIRVLQNFSFKPCKETQI 473
>Q64464:CP3AD_MOUSE Cytochrome P450 3A13 - Mus musculus (Mouse)| Length = 503 Score = 106 bits (265), Expect = 3e-22 Identities = 108/454 (23%), Positives = 196/454 (43%), Gaps = 33/454 (7%) Frame = +1 Query: 175 PGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEVNRFI 354 PG LP +G + K D+ Q K+YG ++ QPV+ D ++ + + Sbjct: 39 PGPKPLPFLGTILAYQKGFWECDI-----QCHKKYGKMWGLYDGRQPVLAITDPDIIKTV 93 Query: 355 FQQEGKLFRSWYPDTANNIFG-----KESIASYDGSFHKYVRSFASRLFGLDSLRD---V 510 +E + T FG K++I+ + K +R+ S F L++ + Sbjct: 94 LVKE-----CYSTFTNRRRFGPVGILKKAISISENEEWKRIRALLSPTFTSGRLKEMFPI 148 Query: 511 LLAEMDCNVTDSLAAWAAEPAIEVKDAVANMVFDLTAKKLIGFS-----------PEKSR 657 + D V + +KD D+ G + EK + Sbjct: 149 INQFTDVLVRNMRQGLGEGKPTSMKDIFGAYSMDVITATSFGVNIDSLNNPQDPFVEKIK 208 Query: 658 KLRKN--FDAFFQGLVSFPLYFPG------TTFYRCIQG--RKNVQKVLKDLLKERLGAP 807 KL K FD F + FP P + F R + +V+++ ++ +KE+ Sbjct: 209 KLLKFDIFDPLFLSVTLFPFLTPVFDALNVSLFPRDVISFFTTSVERMKENRMKEK---- 264 Query: 808 EKRHGDFLDEVVD----ELQSGRGVIDEKFAVDLMAALLFASFATVSSSLTIAMKFLSGH 975 EK+ DFL +++ + + + + V +FA + T SS+L+ A+ L+ H Sbjct: 265 EKQRVDFLQLMINSQNYKTKESHKALSDVEIVAQSVIFIFAGYETTSSALSFALYLLAIH 324 Query: 976 PNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAPGIFRKTLT 1155 P+V + L++E +A L K+ T++ M + V NE R+ +A + R T Sbjct: 325 PDVQKKLQDEIDAALPN-----KAPATYDTLLQMEYLDMVVNETLRLYPIAGRLERVCKT 379 Query: 1156 DVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGI 1335 DV++ G IP G +VMI A+H +P+ + +P F P R+ +++ S ++PFG G Sbjct: 380 DVEINGLFIPKGTVVMIPTFALHKDPKYWPEPEEFRPERFSKKNQDSINPYMYLPFGSGP 439 Query: 1336 RLCVGAEFSRIQIALFLHTLVTKYRWKEIKGGEV 1437 R C+G F+ I + + L ++ + + K E+ Sbjct: 440 RNCIGMRFALINMKVALVRVLQNFTVQPCKETEI 473
>P51590:CP2J3_RAT Cytochrome P450 2J3 - Rattus norvegicus (Rat)| Length = 502 Score = 106 bits (265), Expect = 3e-22 Identities = 110/470 (23%), Positives = 207/470 (44%), Gaps = 29/470 (6%) Frame = +1 Query: 172 PPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEVNRF 351 PPG LPLVG F P L + F +K+YG V P VV + + Sbjct: 44 PPGPWRLPLVGCLFHLDPKQPHLSLQQF----VKKYGNVLSLDFANIPSVVVTGMPLIKE 99 Query: 352 IF-QQEGKLFRSWYPDTANNIFGKESIASYDGSFHKYVRSFAS---RLFGLDSLR-DVLL 516 IF Q E ++F K + G K R FA R FGL + + Sbjct: 100 IFTQMEHNFLNRPVTLLRKHLFNKNGLIFSSGQTWKEQRRFALMTLRNFGLGKKSLEQRI 159 Query: 517 AEMDCNVTDSL---AAWAAEPAIEVKDAVANMVFDLTAKKLIGFSPEKSRKLRKNFDAFF 687 E ++ +++ +P + AV+N++ +T + + + +++ + D Sbjct: 160 QEEAYHLVEAIKDEGGLPFDPHFNINKAVSNIICSVTFGERFEYHDSQFQEMLRLLDEAM 219 Query: 688 --------QGLVSFPL---YFPGTTFYRCIQGRKNVQKVLKDLLKE--RLGAPEKRHGDF 828 Q FP Y PG+ RK ++ + D++K R P++ DF Sbjct: 220 CLESSMMCQLYNIFPRILQYLPGSHQTLFSNWRK-LKLFISDIIKNHRRDWDPDEPR-DF 277 Query: 829 LDEVVDELQSGRGVIDEKFAVDLMAA----LLFASFATVSSSLTIAMKFLSGHPNVVESL 996 +D + E+ F + + L FA T S++L A+ ++ +P V E + Sbjct: 278 IDAFLKEMAKYPDKTTTSFNEENLICSTLDLFFAGTETTSTTLRWALLCMALYPEVQEKM 337 Query: 997 KEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAP-GIFRKTLTDVQVKG 1173 + E + ++ +G + + + SM +T V +E+ R+ N+ P + R+ D + G Sbjct: 338 QAEIDRVIG---QGRQPNLA--DRDSMPYTNAVIHEVQRIGNIIPFNVPREVAVDTYLAG 392 Query: 1174 YTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGIRLCVGA 1353 + +P G +++ + A+H +P+ + P TFNP + E+ + ++F+PF G R C+G Sbjct: 393 FNLPKGTMILTNLTALHRDPKEWATPDTFNPEHFL-ENGQFKKRESFLPFSMGKRACLGE 451 Query: 1354 EFSRIQIALFLHTLVTKYRWKEIKGGEVQ---RISEIVFPEGYHIQIIPR 1494 + +R ++ +F+ +L+ K+ +K ++ R+S + P + + IPR Sbjct: 452 QLARSELFIFITSLIQKFTFKPPVNEKLSLQFRMSVTISPVSHRLCAIPR 501
>Q64459:CP3AB_MOUSE Cytochrome P450 3A11 - Mus musculus (Mouse)| Length = 504 Score = 106 bits (264), Expect = 4e-22 Identities = 105/449 (23%), Positives = 192/449 (42%), Gaps = 28/449 (6%) Frame = +1 Query: 175 PGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEVNRFI 354 PG LP +G ++K D+ + K+YG + P++ D E + + Sbjct: 39 PGPKPLPFLGTVLNYYKGLWKFDMECY-----KKYGKTWGLFDGQTPLLAVTDPETIKNV 93 Query: 355 FQQEG-KLFRSWYPDTANNIFGKESIASYDGSFHKYVRSFASRLFGLDSLRDVLLAEMDC 531 +E +F + I K S D + +Y R+ S F L+++ Sbjct: 94 LVKECFSVFTNRRDFGPVGIMSKAISISKDDEWKRY-RALLSPTFTSGKLKEMFPVIEQY 152 Query: 532 NVTDSLAAWAAEPA-----IEVKDAVANMVFDLTAKKLIGFSP-----------EKSRKL 663 D L + + A + +KD + D+ G + EK++KL Sbjct: 153 G--DILVKYLRQKAKKGKPVTMKDVLGAYSMDVITSTSFGVNVDSLNNPEDPFVEKAKKL 210 Query: 664 RKN--FDAFFQGLVSFPLYFPGTTFYR-CIQGRKNVQ--KVLKDLLKE-RLGAPEKRHGD 825 + FD +V FP P C+ + +++ K D +KE RL + +K D Sbjct: 211 LRFDFFDPLLFSVVLFPFLTPVYEMLNICMFPKDSIEFFKKFVDRMKESRLDSKQKHRVD 270 Query: 826 FLDEVVDELQSGRGVIDEKFAVDLMAA-----LLFASFATVSSSLTIAMKFLSGHPNVVE 990 FL +++ + + + K D+ +FA + T SS+L+ + L+ HP++ + Sbjct: 271 FLQLMMNSHNNSKDKVSHKALSDMEITAQSIIFIFAGYETTSSTLSFTLHSLATHPDIQK 330 Query: 991 SLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAPGIFRKTLTDVQVK 1170 L++E + L K+ T++ M + V NE R+ +A + R DV++ Sbjct: 331 KLQDEIDEALPN-----KAPPTYDTVMEMEYLDMVLNETLRLYPIANRLERVCKKDVELN 385 Query: 1171 GYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGIRLCVG 1350 G IP G VMI A+H +P+ + +P F P R+ E+K S ++PFG G R C+G Sbjct: 386 GVYIPKGSTVMIPSYALHHDPQHWSEPEEFQPERFSKENKGSIDPYVYLPFGNGPRNCLG 445 Query: 1351 AEFSRIQIALFLHTLVTKYRWKEIKGGEV 1437 F+ + + L L ++ + ++ K ++ Sbjct: 446 MRFALMNMKLALTKIMQNFSFQPCKETQI 474
>P08683:CP2CB_RAT Cytochrome P450 2C11 - Rattus norvegicus (Rat)| Length = 500 Score = 106 bits (264), Expect = 4e-22 Identities = 107/446 (23%), Positives = 196/446 (43%), Gaps = 26/446 (5%) Frame = +1 Query: 163 GRLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEV 342 G+LPPG LP++G T Q + D+ K+ K YGP+F L +P VV E Sbjct: 27 GKLPPGPTPLPIIGNTLQIYMK----DIGQSIKKFSKVYGPIFTLYLGMKPFVVLHGYEA 82 Query: 343 NRFIFQQEGKLF--RSWYPDTANNIFGKESIASYDGSFHKYVRSFAS---RLFGLD--SL 501 + G+ F R +P + G I S +G K +R F+ R FG+ ++ Sbjct: 83 VKEALVDLGEEFSGRGSFPVSERVNKGLGVIFS-NGMQWKEIRRFSIMTLRTFGMGKRTI 141 Query: 502 RDVLLAEMDCNVTDSLAAWAA--EPAIEVKDAVANMVFDLTAKKLIGFSPEKSRKLRKNF 675 D + E C V + + A +P + A N++ + + + L F Sbjct: 142 EDRIQEEAQCLVEELRKSKGAPFDPTFILGCAPCNVICSIIFQNRFDYKDPTFLNLMHRF 201 Query: 676 DAFFQGLVS--------FPL---YFPGTTFYRCIQGRKNVQKVLKDLLKERLGAPEKRHG 822 + F+ S FP YFPG+ + ++ ++ + + +KE + +K + Sbjct: 202 NENFRLFSSPWLQVCNTFPAIIDYFPGS-HNQVLKNFFYIKNYVLEKVKEHQESLDKDNP 260 Query: 823 -DFLDEVVDELQSGRGVIDEKFAVDLMAALLFASFA----TVSSSLTIAMKFLSGHPNVV 987 DF+D +++++ + +F ++ + A + F T S++L + L H +V Sbjct: 261 RDFIDCFLNKMEQEKHNPQSEFTLESLVATVTDMFGAGTETTSTTLRYGLLLLLKHVDVT 320 Query: 988 ESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAPGIFRKTLT-DVQ 1164 ++EE E ++ G ++ M +T V +EI R ++ P +T D++ Sbjct: 321 AKVQEEIERVI-----GRNRSPCMKDRSQMPYTDAVVHEIQRYIDLVPTNLPHLVTRDIK 375 Query: 1165 VKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGIRLC 1344 + Y IP G V++S ++ + + F +P F+P + DE FMPF G R+C Sbjct: 376 FRNYFIPKGTNVIVSLSSILHDDKEFPNPEKFDPGHFLDERGNFKKSDYFMPFSAGKRIC 435 Query: 1345 VGAEFSRIQIALFLHTLVTKYRWKEI 1422 G +R ++ LF T++ + K + Sbjct: 436 AGEALARTELFLFFTTILQNFNLKSL 461
>Q9CX98:CP2U1_MOUSE Cytochrome P450 2U1 - Mus musculus (Mouse)| Length = 530 Score = 105 bits (263), Expect = 5e-22 Identities = 120/492 (24%), Positives = 215/492 (43%), Gaps = 40/492 (8%) Frame = +1 Query: 79 ASLCGLAAVVAGWLAHCVYKWTNPACSTGRLPPGSMGLPLVGE-----TFQFFKPSPSLD 243 A L L AV+ GW+ W + G +PPG PLVG +F +P L Sbjct: 27 ALLLCLLAVLLGWV------WLRRQRACG-IPPGPKPRPLVGNFGHLLVPRFLRPQFWLG 79 Query: 244 VPA--------FYKQRLKR-YGPVFKTSLVGQPVVVSMDAEVNRFIFQQEGKLFRSWYPD 396 + Y R+ R YG +F + + VVV D R Q+ ++F Sbjct: 80 SGSQTDTVGQHVYLARMARVYGNIFSFFIGHRLVVVLSDFHSVREALVQQAEVFSDRPRM 139 Query: 397 TANNIFGKES--IASYDGSFHKYVRSFAS---RLFGLDSLR-DVLLAEMDCNVTDSLAAW 558 +I KE + ++ G K R F+ R FGL L + + E V +++ Sbjct: 140 PLISIMTKEKGIVFAHYGPIWKQQRRFSHSTLRHFGLGKLSLEPRIIEEFAYVKEAMQKH 199 Query: 559 AAEPAIE---VKDAVANMV--------FDLTAKKLIGFSPEKSRKLR--KNFDAFFQGLV 699 P + +AV+N++ FD T K+ SR L + F + Sbjct: 200 GEAPFSPFPIISNAVSNIICSLCFGQRFDYTNKEFKKVLDFMSRGLEICLHSQLFLINIC 259 Query: 700 SFPLYFPGTTFYRCIQGRKNVQKVLKDLLKERLGAPEKRHG-DFLDEVVDELQSGRGV-- 870 + Y P F Q +++ LK++++E + + + DF+D + ++ +G Sbjct: 260 PWFYYLPFGPFKELRQIERDISCFLKNIIREHQESLDASNPQDFIDMYLLHMEEEQGASR 319 Query: 871 ---IDEKFAVDLMAALLFASFATVSSSLTIAMKFLSGHPNVVESLKEEHEAILKKREEGA 1041 DE + ++ L A T ++SL + ++S +P+V + + EE E ++ G Sbjct: 320 RSSFDEDYLFYIIGDLFIAGTDTTTNSLLWCLLYMSLNPDVQKKVHEEIERVI-----GC 374 Query: 1042 KSGITWEEYKSMTFTAQVTNEISRVSNVAP-GIFRKTLTDVQVKGYTIPAGWLVMISPMA 1218 + + M +T E+ R+S V P I T ++G+TIP G +V+I+ + Sbjct: 375 DRAPSLTDKAQMPYTEATIMEVQRLSMVVPLAIPHMTSEKTVLQGFTIPKGTVVLINLWS 434 Query: 1219 VHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGIRLCVGAEFSRIQIALFLHTLV 1398 VH +P ++E P F P R+ D+ + + F+PFG G R+C+G + +++++ L +L+ Sbjct: 435 VHRDPAIWEKPDDFCPHRFLDDQGQLLKRETFIPFGIGKRVCMGEQLAKMELFLMFVSLM 494 Query: 1399 TKYRWKEIKGGE 1434 + + +G E Sbjct: 495 QTFTFALPEGSE 506
>Q29473:CP2DF_CANFA Cytochrome P450 2D15 - Canis familiaris (Dog)| Length = 500 Score = 105 bits (263), Expect = 5e-22 Identities = 114/481 (23%), Positives = 211/481 (43%), Gaps = 38/481 (7%) Frame = +1 Query: 166 RLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVV--SMDAE 339 R PPG +P+VG Q P ++ Q R+G VF L PVVV ++A Sbjct: 35 RYPPGPTPVPMVGNLLQMDFQEPI----CYFSQLQGRFGNVFSLELAWTPVVVLNGLEAV 90 Query: 340 VNRFIFQQEGKLFRSWYPDTANNIFGKES----IASYDGSFHKYVRSFASRL--FGLD-- 495 + + E R P + G ES +A Y ++ + R S L FGL Sbjct: 91 REALVHRSEDTADRPPMPIYDHLGLGPESQGLFLARYGRAWREQRRFSLSTLRNFGLGRK 150 Query: 496 SLRDVLLAEMDCNVTDSLAAWAAE------PAIEVKDAVANMVFDLTAKKLIGFSPEK-- 651 SL + E C AA+A + P + AV+N++ LT + + + Sbjct: 151 SLEQWVTEEASC----LCAAFAEQAGRPFGPGALLNKAVSNVISSLTYGRRFEYDDPRLL 206 Query: 652 ------SRKLRKNFDAFFQGLVSFP--LYFPGTTFYRCIQGRKNVQKVLKDLLKE--RLG 801 + L+++ + L S P L+ PG + +K + + ++++E + Sbjct: 207 QLLELTQQALKQDSGFLREALNSIPVLLHIPGLAS-KVFSAQKAIITLTNEMIQEHRKTR 265 Query: 802 APEKRHGDFLDEVVDELQSGRG----VIDEKFAVDLMAALLFASFATVSSSLTIAMKFLS 969 P + +D VDE++ +G +E+ + + L A + S +LT A+ + Sbjct: 266 DPTQPPRHLIDAFVDEIEKAKGNPKTSFNEENLCMVTSDLFIAGMVSTSITLTWALLLMI 325 Query: 970 GHPNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAP-GIFRK 1146 HP+V +++E + ++ RE+ + G + M FT V +E+ R ++ P G+ Sbjct: 326 LHPDVQRRVQQEIDEVIG-REQLPEMG----DQTRMPFTVAVIHEVQRFGDIVPLGVPHM 380 Query: 1147 TLTDVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFG 1326 T D +V+G+ IP G ++ + +V + ++++ P F P + D + FMPF Sbjct: 381 TSRDTEVQGFLIPKGTTLITNLSSVLKDEKVWKKPFRFYPEHFLDAQGHFVKHEAFMPFS 440 Query: 1327 GGIRLCVGAEFSRIQIALFLHTLVTKYRWKEIKGGEVQRISEIVF-----PEGYHIQIIP 1491 G R+C+G +R+++ LF L+ ++ + + G+ + VF P + + + P Sbjct: 441 AGRRVCLGEPLARMELFLFFTCLLQRFSF-SVPAGQPRPSDHGVFTFLKVPAPFQLCVEP 499 Query: 1492 R 1494 R Sbjct: 500 R 500
>P33260:CP2CI_HUMAN Cytochrome P450 2C18 - Homo sapiens (Human)| Length = 490 Score = 105 bits (262), Expect = 6e-22 Identities = 110/444 (24%), Positives = 189/444 (42%), Gaps = 26/444 (5%) Frame = +1 Query: 163 GRLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEV 342 GRLP G LP++G Q S + F K YGPVF +P+VV E Sbjct: 27 GRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSKV----YGPVFTVYFGLKPIVVLHGYEA 82 Query: 343 NRFIFQQEGKLF--RSWYPDTANNIFGKESIASYDGSFHKYVRSFAS---RLFGLD--SL 501 + G+ F R +P A + I +G K +R F R FG+ S+ Sbjct: 83 VKEALIDHGEEFSGRGSFP-VAEKVNKGLGILFSNGKRWKEIRRFCLMTLRNFGMGKRSI 141 Query: 502 RDVLLAEMDCNVTD--SLAAWAAEPAIEVKDAVANMV--------FDLTAKKLIGFSPEK 651 D + E C V + A +P + A N++ FD ++ + + Sbjct: 142 EDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICSVIFHDRFDYKDQRFLNLMEKF 201 Query: 652 SRKLRKNFDAFFQGLVSFPL---YFPGTTFYRCIQGRKNVQKVLKDLLKERLGAPEKRHG 822 + LR + Q +FP Y PG+ + + ++ + + +KE + + Sbjct: 202 NENLRILSSPWIQVCNNFPALIDYLPGS-HNKIAENFAYIKSYVLERIKEHQESLDMNSA 260 Query: 823 -DFLDEVVDELQSGRGVIDEKFAVDLMAALLFASFA----TVSSSLTIAMKFLSGHPNVV 987 DF+D + +++ + +F V+ + A + F T S++L + L +P V Sbjct: 261 RDFIDCFLIKMEQEKHNQQSEFTVESLIATVTDMFGAGTETTSTTLRYGLLLLLKYPEVT 320 Query: 988 ESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAPGIFRKTLT-DVQ 1164 ++EE E ++ G ++ M +T V +EI R ++ P +T DV+ Sbjct: 321 AKVQEEIECVV-----GRNRSPCMQDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVTCDVK 375 Query: 1165 VKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGIRLC 1344 K Y IP G ++ S +V N + F +P F+P + D+S FMPF G R+C Sbjct: 376 FKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFKKSDYFMPFSAGKRMC 435 Query: 1345 VGAEFSRIQIALFLHTLVTKYRWK 1416 +G +R+++ LFL T++ + K Sbjct: 436 MGEGLARMELFLFLTTILQNFNLK 459
>P24463:CP3AC_CANFA Cytochrome P450 3A12 - Canis familiaris (Dog)| Length = 503 Score = 104 bits (260), Expect = 1e-21 Identities = 113/471 (23%), Positives = 202/471 (42%), Gaps = 29/471 (6%) Frame = +1 Query: 175 PGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEVNRFI 354 PG LP VG + D+ F K YG ++ QPV+ D ++ + + Sbjct: 39 PGPTPLPFVGTALGYRNGFYVFDMKCFSK-----YGRMWGFYDGRQPVLAITDPDMIKTV 93 Query: 355 FQQEGKLFRSWYPDTANNIFGKESIASYDGSFHKYVRSFASRLFGLDSLRDV--LLAEMD 528 +E + F K +I+ + K +R+ S F L+++ ++ + Sbjct: 94 LVKECYSVFTNRRTLGPVGFMKSAISLSEDEEWKRMRTLLSPTFTTGKLKEMFPIIGQYG 153 Query: 529 CNVTDSLAAWAAE-PAIEVKDAVANMVFDLTAKKLIGFS-----------PEKSRKLRKN 672 + ++L A + AI +KD D+ G + E ++KL K Sbjct: 154 DVLVNNLRKEAEKGKAINLKDVFGAYSMDVITSTSFGVNIDSLNHPQDPFVENTKKLLKF 213 Query: 673 --FDAFFQGLVSFPLYFPGTTFYRCIQGRKNV----QKVLKDLLKERLGAPEKRHGDFLD 834 D FF ++ FP P K V +K ++ + + RL +K DFL Sbjct: 214 DFLDPFFFSILLFPFLTPVFEILNIWLFPKKVTDFFRKSVERMKESRLKDKQKHRVDFLQ 273 Query: 835 EVVDELQSGRGVIDEKFAVDLMAA-----LLFASFATVSSSLTIAMKFLSGHPNVVESLK 999 +++ Q+ + + K DL +FA + T S+SL+ M L+ HP+V + L+ Sbjct: 274 LMINS-QNSKEMDTHKALSDLELVAQSIIFIFAGYETTSTSLSFLMYELATHPDVQQKLQ 332 Query: 1000 EEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAPGIFRKTLTDVQVKGYT 1179 EE +A K+ T++ M + V NE R+ +A + R DV++ G Sbjct: 333 EEIDATFPN-----KALPTYDALVQMEYLDMVLNETLRLYPIAGRLERVCKKDVEISGVF 387 Query: 1180 IPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGIRLCVGAEF 1359 IP G +VM+ +H + L+ +P F P R+ ++K S ++PFG G R C+G F Sbjct: 388 IPKGTVVMVPTFTLHRDQSLWPEPEEFRPERFSRKNKDSINPYTYLPFGTGPRNCIGMRF 447 Query: 1360 SRIQIALFLHTLVTKYRWKEIKGGEVQ---RISEIVFPE-GYHIQIIPREG 1500 + + + L L ++ + +K K ++ I+ PE +++ PR+G Sbjct: 448 AIMNMKLALVRVLQNFSFKPCKETQIPLKLNAQGIIQPEKPIVLKVEPRDG 498
>P20815:CP3A5_HUMAN Cytochrome P450 3A5 - Homo sapiens (Human)| Length = 502 Score = 104 bits (260), Expect = 1e-21 Identities = 109/448 (24%), Positives = 192/448 (42%), Gaps = 27/448 (6%) Frame = +1 Query: 175 PGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEVNRFI 354 PG LPL+G + + D + K+YG ++ T PV+ D +V R + Sbjct: 39 PGPTPLPLLGNVLSYRQGLWKFDTECY-----KKYGKMWGTYEGQLPVLAITDPDVIRTV 93 Query: 355 FQQEGKLFRSWYPDTANNIFGKESIASYDGSFHKYVRSFASRLFGLDSLRDV--LLAEMD 528 +E + F K +I+ + K +RS S F L+++ ++A+ Sbjct: 94 LVKECYSVFTNRRSLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYG 153 Query: 529 CNVTDSLAAWAAE-PAIEVKDAVANMVFDLTAKKLIGFS-----------PEKSRKLRKN 672 + +L A + + +KD D+ G + E ++K K Sbjct: 154 DVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKF 213 Query: 673 --FDAFFQGLVSFPLYFPGTTFYRCIQGRKN----VQKVLKDLLKERLGAPEKRHGDFLD 834 D F ++ FP P K+ + K + + K RL +K DFL Sbjct: 214 GFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQ 273 Query: 835 EVVD-----ELQSGRGVIDEKFAVDLMAALLFASFATVSSSLTIAMKFLSGHPNVVESLK 999 ++D E +S + + D + A + +FA + T SS L+ + L+ HP+V + L+ Sbjct: 274 LMIDSQNSKETESHKALSDLELAAQSII-FIFAGYETTSSVLSFTLYELATHPDVQQKLQ 332 Query: 1000 EEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAPGIFRKTLTDVQVKGYT 1179 +E +A+L + + EY M V NE R+ VA + R DV++ G Sbjct: 333 KEIDAVLPNKAPPTYDAVVQMEYLDM-----VVNETLRLFPVAIRLERTCKKDVEINGVF 387 Query: 1180 IPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFM--PFGGGIRLCVGA 1353 IP G +V+I A+H +P+ + +P F P R+ SKK + ++ PFG G R C+G Sbjct: 388 IPKGSMVVIPTYALHHDPKYWTEPEEFRPERF---SKKKDSIDPYIYTPFGTGPRNCIGM 444 Query: 1354 EFSRIQIALFLHTLVTKYRWKEIKGGEV 1437 F+ + + L L ++ + +K K ++ Sbjct: 445 RFALMNMKLALIRVLQNFSFKPCKETQI 472
>O14442:CP51_UNCNE Cytochrome P450 51 - Uncinula necator (Grape powdery mildew)| Length = 524 Score = 104 bits (259), Expect = 1e-21 Identities = 103/456 (22%), Positives = 191/456 (41%), Gaps = 44/456 (9%) Frame = +1 Query: 193 PLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEVNRFIFQQEGK 372 P++G T + +D FY +YG +F L+G+ V V + + N FI GK Sbjct: 60 PIIGSTISY-----GIDPYKFYFDCRAKYGDIFTFILLGKKVTVYLGLQGNNFILN--GK 112 Query: 373 L----FRSWYPDTANNIFGKESIASYDGSFHKYVRSFASRLFGLDSLRD---VLLAEMDC 531 L Y + +FG++ + S + F +++ ++ E++ Sbjct: 113 LKDVNAEEIYTNLTTPVFGRDVVYDCPNSKLMEQKKFMKTALTIEAFHSYVTIIQNEVEA 172 Query: 532 NVTDSLAAWAAEPAIEVKDAVANMVFDLTAKKLIGFSPEKSRKLRKNFDAFFQGL----- 696 + + ++ + + +A + + L G ++R+NFD+ F L Sbjct: 173 YINNCVSFQGESGTVNISKVMAEITIYTASHALQG------EEVRENFDSSFAALYHDLD 226 Query: 697 -----VSFPLYFPGTTFYRCIQ-GRKNVQKVLKDLLKERLGAPEKRHGDFLDEVVDEL-- 852 ++F Y+ + R ++ V + ++++ R EKR G+ +++ EL Sbjct: 227 MGFTPINFTFYWAPLPWNRARDHAQRTVARTYMNIIQAR--REEKRSGENKHDIMWELMR 284 Query: 853 ---QSGRGVIDEKFAVDLMAALLFASFATVSSSLTIAMKFLSGHPNVVESLKEEHEAILK 1023 + G V D + A +M ALL A + SS+ + M +L+ P+++E L EE I Sbjct: 285 STYKDGTPVPDREIA-HMMIALLMAGQHSSSSTSSWIMLWLAARPDIMEELYEEQLRIFG 343 Query: 1024 KREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAPGIFRKTLTDVQVKG--YTIPAGWL 1197 E + +E+ + V E+ R+ I RK + V G Y IP + Sbjct: 344 S--EKPFPPLQYEDLSKLQLHQNVLKEVLRLHAPIHSIMRKVKNPMIVPGTKYVIPTSHV 401 Query: 1198 VMISPMAVHLNPELFEDPLTFNPWRWQDESKK------------------STMLKN-FMP 1320 ++ SP + F DPL ++P RW S K ST + ++P Sbjct: 402 LISSPGCTSQDATFFPDPLKWDPHRWDIGSGKVLGNDAVDEKYDYGYGLTSTGASSPYLP 461 Query: 1321 FGGGIRLCVGAEFSRIQIALFLHTLVTKYRWKEIKG 1428 FG G C+G +F+ +Q+ + T+V +R++ I G Sbjct: 462 FGAGRHRCIGEQFATLQLVTIMATMVRFFRFRNIDG 497
>Q29496:CP3AO_SHEEP Cytochrome P450 3A24 - Ovis aries (Sheep)| Length = 503 Score = 104 bits (259), Expect = 1e-21 Identities = 106/450 (23%), Positives = 193/450 (42%), Gaps = 30/450 (6%) Frame = +1 Query: 178 GSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEVNRFIF 357 G LP G + K D F K+YG ++ QP++V D +V + + Sbjct: 40 GPRPLPYFGNVLSYRKGVCEFDEECF-----KKYGKMWGVFEGKQPLLVITDPDVIKTVL 94 Query: 358 QQEGKLFRSWYPDTANNIFG-----KESIASYDGSFHKYVRSFASRLFGLDSLRDV--LL 516 +E + T +FG K +++ + K +R+ S F L+D+ ++ Sbjct: 95 VKE-----CYSVFTNRRVFGPMGIMKNAVSVAEDEQWKRIRTLLSPTFTSGKLKDMFPII 149 Query: 517 AEMDCNVTDSLAAWAAE-PAIEVKDAVANMVFDLTAKKLIG------------FSPEKSR 657 + + +L A + ++ +KD D+ G F + Sbjct: 150 GKYGDVLVRNLRKEAEKGKSVNMKDIFGAYSMDVITSTSFGVNIDSLGNPQDPFVENAKK 209 Query: 658 KLRKNF-DAFFQGLVSFPLYFPGTTFYRCIQGRKN----VQKVLKDLLKERLGAPEKRHG 822 LR N D F +V FP P K+ + K +K + + RL +K Sbjct: 210 LLRFNILDPFLLSVVLFPFLVPIFEVLNITMFPKSAVDFLTKSVKRIKESRLKDNQKPRV 269 Query: 823 DFLDEVVDELQSGRGVIDEKFAVD--LMAA---LLFASFATVSSSLTIAMKFLSGHPNVV 987 DFL +++ Q+ + + K D LMA +FA + T S++L+ + L+ HP+V Sbjct: 270 DFLQLMINS-QNSKETDNHKALSDQELMAQSVIFIFAGYETTSNTLSFLLYILATHPDVQ 328 Query: 988 ESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAPGIFRKTLTDVQV 1167 + L+EE +A K+ T++ M + V NE R+ +A + R DV++ Sbjct: 329 QKLQEEIDATFPN-----KAPPTYDVLAQMEYLDMVVNETLRMFPIAVRLDRLCKKDVEI 383 Query: 1168 KGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGIRLCV 1347 G +IP G V + +H +P+L+ +P F P R+ ++K S ++PFG G R C+ Sbjct: 384 HGVSIPKGTAVTVPIFVLHRDPQLWPEPEEFRPERFSKKNKDSINPYVYLPFGTGPRNCI 443 Query: 1348 GAEFSRIQIALFLHTLVTKYRWKEIKGGEV 1437 G F+ + + L + ++ + +K K ++ Sbjct: 444 GMRFAIMNMKLAIVRVLQNFSFKPCKETQI 473
>Q6GUQ4:CP2E1_MACMU Cytochrome P450 2E1 - Macaca mulatta (Rhesus macaque)| Length = 493 Score = 103 bits (258), Expect = 2e-21 Identities = 114/477 (23%), Positives = 202/477 (42%), Gaps = 31/477 (6%) Frame = +1 Query: 157 STGRLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDA 336 S+ LPPG LP++G FQ ++P + + +R+GPVF + + VVV Sbjct: 28 SSWNLPPGPFPLPIIGNLFQL----ELKNIPKSFTRLAQRFGPVFTLYVGSRRVVVVHGY 83 Query: 337 EVNRFIFQQEGKLFRSWYPDTANNIFGKESIASYDGSFHKYVRSFAS---RLFGLDSLRD 507 + R + F A + I +G K +R F+ R +G+ + Sbjct: 84 KAVREVLLDHKDEFSGRGDIPAFHAHRDRGIIFNNGPTWKDIRRFSLTTLRNYGMGKQGN 143 Query: 508 VLLAEMDCN-VTDSLAAWAAEP---AIEVKDAVANMVFDLTAKKLIGFSPEKSRKLRKNF 675 + + + + ++L +P + A N++ D+ +K ++ EK +L F Sbjct: 144 ESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLF 203 Query: 676 DAFFQGLVSFP---LY--FPGTTFYRCIQGRKNVQKVLKDLLKERLGAPEKRH------- 819 + FQ L+S P LY FP Y RK ++ V + +KE + K H Sbjct: 204 NENFQ-LLSTPWLQLYNNFPSLLHYLPGSHRKVMKNVAE--IKEYVSERVKEHLQSLDPN 260 Query: 820 --GDFLDEVVDELQSGRGVIDEKFAVD----LMAALLFASFATVSSSLTIAMKFLSGHPN 981 D D ++ E++ + + + +D +A L FA T S++L + L +P Sbjct: 261 CPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPE 320 Query: 982 VVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAPGIFRKTLT-D 1158 + E L EE + ++ G ++ + M + V +EI R + P T D Sbjct: 321 IEEKLHEEIDRVI-----GPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRD 375 Query: 1159 VQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGIR 1338 +GY IP G +++ + +V + + F DP F P + DES K F PF G R Sbjct: 376 TIFRGYIIPKGTVIVPTLDSVLYDNQEFPDPEKFKPEHFLDESGKFKYSDYFKPFSAGKR 435 Query: 1339 LCVGAEFSRIQIALFLHTLVTKYRWKEIKGGEVQRISEI-----VFPEGYHIQIIPR 1494 +C G +R+++ L L ++ + K + + IS + P + + +IPR Sbjct: 436 VCAGEGLARMELFLLLSAILQHFNLKPLVDPKDIDISPVNIGFGCIPPRFKLCVIPR 492
>P51538:CP3A9_RAT Cytochrome P450 3A9 - Rattus norvegicus (Rat)| Length = 503 Score = 103 bits (256), Expect = 3e-21 Identities = 103/454 (22%), Positives = 196/454 (43%), Gaps = 33/454 (7%) Frame = +1 Query: 175 PGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEVNRFI 354 PG LP +G + K D K K+YG ++ QPV+ D ++ + + Sbjct: 39 PGPKPLPFLGTILAYRKGFWEFD-----KYCHKKYGKLWGLYDGRQPVLAITDPDIIKTV 93 Query: 355 FQQEGKLFRSWYPDTANNIFG-----KESIASYDGSFHKYVRSFASRLFGLDSLRD---V 510 +E + T FG K++I+ + K +R+ S F L++ + Sbjct: 94 LVKE-----CYSTFTNRRNFGPVGILKKAISISEDEEWKRIRALLSPTFTSGKLKEMFPI 148 Query: 511 LLAEMDCNVTDSLAAWAAEPAIEVKDAVANMVFDLTAKKLIGFSP-----------EKSR 657 + D V + +KD D+ G + EK + Sbjct: 149 INQYTDMLVRNMRQGSEEGKPTSMKDIFGAYSMDVITATSFGVNVDSLNNPQDPFVEKVK 208 Query: 658 KLRKN--FDAFFQGLVSFPLYFP------GTTFYRCIQG--RKNVQKVLKDLLKERLGAP 807 KL K FD F + FP P + F R + + +V+++ ++ +KE+ Sbjct: 209 KLLKFDIFDPLFLSVTLFPFLTPLFEALNVSMFPRDVIDFFKTSVERMKENRMKEK---- 264 Query: 808 EKRHGDFLDEVVD----ELQSGRGVIDEKFAVDLMAALLFASFATVSSSLTIAMKFLSGH 975 EK+ DFL +++ +++ + + V +FA + T SS+L+ + L+ H Sbjct: 265 EKQRMDFLQLMINSQNSKVKDSHKALSDVEIVAQSVIFIFAGYETTSSALSFVLYLLAIH 324 Query: 976 PNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAPGIFRKTLT 1155 P++ + L++E +A L K+ T++ M + V NE R+ +A + R T Sbjct: 325 PDIQKKLQDEIDAALPN-----KAHATYDTLLQMEYLDMVVNETLRLYPIAGRLERVCKT 379 Query: 1156 DVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGI 1335 DV++ G IP G +VMI A+H +P + +P F P R+ +++ + ++PFG G Sbjct: 380 DVEINGVFIPKGTVVMIPTFALHKDPHYWPEPEEFRPERFSKKNQDNINPYMYLPFGNGP 439 Query: 1336 RLCVGAEFSRIQIALFLHTLVTKYRWKEIKGGEV 1437 R C+G F+ + + + L ++ + ++ K ++ Sbjct: 440 RNCIGMRFALMNMKVALFRVLQNFSFQPCKETQI 473
>O46658:CP2DP_PIG Cytochrome P450 2D25 - Sus scrofa (Pig)| Length = 500 Score = 103 bits (256), Expect = 3e-21 Identities = 115/485 (23%), Positives = 208/485 (42%), Gaps = 42/485 (8%) Frame = +1 Query: 166 RLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEVN 345 R PPG M LP +G Q P L + Q +R+G VF + +PVVV +N Sbjct: 35 RYPPGPMPLPGLGNLLQVNFQDPRLS----FIQLRRRFGDVFSLQQIWRPVVV-----LN 85 Query: 346 RFIFQQEGKLFRSWYPDTANNIFGKESI-----------ASYDGSFHKYVRSFASRL--F 486 +E + S +F E + A Y ++ + R S L F Sbjct: 86 GLAAVREALVSHSHETSDRPPVFILEHLGYGPRSEGVILARYGKAWREQRRFSVSTLRNF 145 Query: 487 GLD--SLRDVLLAEMDCNVTDSLAAWAAEPAIE---VKDAVANMVFDLTAKKLIGFSPEK 651 GL SL + + E C + + A A P + AV+N++ LT + ++ + Sbjct: 146 GLGKKSLEEWVTQEASC-LCAAFADQAGRPFSPNNLLNKAVSNVIASLTFARRFEYNDPR 204 Query: 652 SRKL--------RKNFDAFFQGLVSFPL--YFPGTTFYRCIQGRKNVQKVLKDLLKER-- 795 KL ++ Q L + P+ + PG + +K ++ +L+ E Sbjct: 205 MLKLLDLVLEGLKEEVGLMRQVLEAMPVLRHIPGLCA-KLFPRQKAFLVMIDELITEHKM 263 Query: 796 ---LGAPEKRHGDFLDEVVDELQSGRGVIDEKFAVD----LMAALLFASFATVSSSLTIA 954 L P + D D +DE++ +G + F + ++A L A T S++L A Sbjct: 264 TRDLAQPPR---DLTDAFLDEMKEAKGNPESSFNDENLRLVVAHLFSAGMITTSTTLAWA 320 Query: 955 MKFLSGHPNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAP- 1131 + + HP+V +++E + ++ G ++ M FT V +E+ R ++ P Sbjct: 321 LLLMILHPDVQRRVQQEIDEVI-----GHVRQPEIKDQALMPFTLAVLHEVQRFGDIVPL 375 Query: 1132 GIFRKTLTDVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKN 1311 G+ T D++V+G+ IP G ++ + +V + +++ P F P + D + T + Sbjct: 376 GVAHMTSCDIEVQGFLIPKGTTLITNLTSVLKDETVWKKPFRFYPEHFLDAQGRFTKQEA 435 Query: 1312 FMPFGGGIRLCVGAEFSRIQIALFLHTLVTKYRWKEIKG----GEVQRISEIVFPEGYHI 1479 FMPF G R C+G +R+++ LF TL+ + + G + + ++FP Y + Sbjct: 436 FMPFSAGRRSCLGEPLARMELFLFFTTLLQAFSFSVPTGQPCPSDHGVFAFLLFPSPYQL 495 Query: 1480 QIIPR 1494 +PR Sbjct: 496 CAVPR 500
>P79401:CP3AT_PIG Cytochrome P450 3A29 - Sus scrofa (Pig)| Length = 503 Score = 102 bits (255), Expect = 4e-21 Identities = 108/476 (22%), Positives = 204/476 (42%), Gaps = 34/476 (7%) Frame = +1 Query: 175 PGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEVNRFI 354 PG LP G + K V F K+ ++YG ++ QP++ D + + + Sbjct: 39 PGPRPLPYFGNILGYRK-----GVDHFDKKCFQQYGKMWGVYDGRQPLLAVTDPNMIKSV 93 Query: 355 FQQEGKLFRSWYPDTANNIFG-----KESIASYDGSFHKYVRSFASRLFGLDSLRDV--L 513 +E + T FG + +++ + K +R+ S F L+++ + Sbjct: 94 LVKE-----CYSVFTNRRSFGPLGAMRNALSLAEDEEWKRIRTLLSPTFTSGKLKEMFPI 148 Query: 514 LAEMDCNVTDSLAAWAAE-PAIEVKDAVANMVFDLTAKKLIGFS-----------PEKSR 657 ++ + +L A + + +KD D+ G + E S+ Sbjct: 149 ISHYGDLLVSNLRKEAEKGKPVTMKDIFGAYSMDVITSTAFGVNIDSLNNPQDPFVENSK 208 Query: 658 KLRKN--FDAFFQGLVSFPLYFPGTTFYRCIQGRKN----VQKVLKDLLKERLGAPEKRH 819 KL K FD F L+ FP P K+ K +K + + RL +KR Sbjct: 209 KLLKFSFFDPFLLSLIFFPFLTPIFEVLNITLFPKSSVNFFTKSVKRMKESRLTDQQKRR 268 Query: 820 GDFLDEVVD-----ELQSGRGVIDEKFAVDLMAALLFASFATVSSSLTIAMKFLSGHPNV 984 D L +++ E+ + + +E+ + +FA + T SS+L++ L+ HP+V Sbjct: 269 VDLLQLMINSQNSKEMDPHKSLSNEELVAQGII-FIFAGYETTSSALSLLAYELATHPDV 327 Query: 985 VESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAPGIFRKTLTDVQ 1164 + L+EE EA K+ T++ M + V NE R+ +A + R DV+ Sbjct: 328 QQKLQEEIEATFPN-----KAPPTYDALAQMEYLDMVVNETLRLYPIAARLERACKKDVE 382 Query: 1165 VKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGIRLC 1344 + G +P G +V++ +H +P+L+ +P F P R+ + K + ++PFG G R C Sbjct: 383 IHGVFVPKGTVVVVPVFVLHRDPDLWPEPEEFRPERFSKKHKDTINPYTYLPFGTGPRNC 442 Query: 1345 VGAEFSRIQIALFLHTLVTKYRWKEIKGGEVQ---RISEIVFPE-GYHIQIIPREG 1500 +G F+ + + L L ++ + +K K ++ + PE ++I+PR+G Sbjct: 443 IGMRFALMNMKLALVRVLQNFSFKPCKETQIPLKLTTQGLTQPEKPVVLKILPRDG 498
>P52786:CP2J1_RABIT Cytochrome P450 2J1 - Oryctolagus cuniculus (Rabbit)| Length = 501 Score = 102 bits (255), Expect = 4e-21 Identities = 105/471 (22%), Positives = 208/471 (44%), Gaps = 30/471 (6%) Frame = +1 Query: 172 PPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAE-VNR 348 PPG LP +G F L + F +K+YG +F L G+ +V+ + Sbjct: 44 PPGPWRLPFLGNLFTLDMEKSHLQLQQF----VKKYGNLFCLDLAGKSIVIVTGLPLIKE 99 Query: 349 FIFQQEGKLFRSWYPDTANNIFGKESIASYDGSFHKYVRSFAS---RLFGLD--SLRDVL 513 + + P F K + G K R FA R FGL SL + + Sbjct: 100 VLVHMDQNFINRPVPPIRERSFKKNGLIMSSGQLWKEQRRFALMTLRNFGLGKKSLEERI 159 Query: 514 LAEMDCNVTDSLAAWAAEPA---IEVKDAVANMVFDLTAKKLIGFSPEKSRKLRKNFDA- 681 E ++T+++ +P ++ +AV+N++ +T + + + ++L K FD Sbjct: 160 QEEAR-HLTEAMEKEGGQPFDAHFKINNAVSNIICSITFGERFEYHDGQFQELLKLFDEV 218 Query: 682 -FFQGLVSFPLY---------FPG---TTFYRCIQGRKNVQKVLKDLLKERLGAPEKRHG 822 + + + LY PG T F + V ++L++ K+ A + Sbjct: 219 MYLEASMLCQLYNIFPWIMKFLPGAHQTLFSNWKKLELFVSRMLENHKKDWNPAETR--- 275 Query: 823 DFLDEVVDELQSGRGVIDEKFAVDLMAAL---LFASFATVSSSLTIAMKFLSGHPNVVES 993 DF+D + E+ G F + + LF + +S + + F++ +P + E Sbjct: 276 DFIDAYLKEMSKYPGSATSSFNEENLICSTLDLFLAGTETTSDMRWGLLFMALYPEIQEK 335 Query: 994 LKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAP-GIFRKTLTDVQVK 1170 + E ++++ + ++ + + +S+ +T V +E+ R+ N+ P + R+ D + Sbjct: 336 VHAEIDSVIGQWQQPSMAS-----RESLPYTNAVIHEVQRMGNILPLNVPREVTVDTTLA 390 Query: 1171 GYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGIRLCVG 1350 GY +P G +V+ + A+H +PE + P TFNP + E+ + + F+PF G R C+G Sbjct: 391 GYHLPKGTVVLTNLTALHKDPEEWATPDTFNPEHFL-ENGQFKKKEAFIPFSIGKRACLG 449 Query: 1351 AEFSRIQIALFLHTLVTKYRWKEIKGGEVQ---RISEIVFPEGYHIQIIPR 1494 + ++ ++ +F +L+ K+ +K ++ R+ + P + I IPR Sbjct: 450 EQLAKSELFIFFTSLMQKFTFKPPSDEKLTLNFRMGITLSPVKHRICAIPR 500
>O18963:CP2E1_BOVIN Cytochrome P450 2E1 - Bos taurus (Bovine)| Length = 495 Score = 102 bits (255), Expect = 4e-21 Identities = 119/503 (23%), Positives = 207/503 (41%), Gaps = 35/503 (6%) Frame = +1 Query: 91 GLAAVVAGWLAHCVYK--WTNPACSTGRLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQ 264 G+ + W+A ++ W + S+ +LPPG LP++G Q ++P + + Sbjct: 5 GITVALLVWMATLLFISIWKH-IYSSWKLPPGPFPLPIIGNLLQL----DIKNIPKSFTR 59 Query: 265 RLKRYGPVFKTSLVGQPVVVSMDAEVNRFIFQQEGKLFRSWYPDTANNIFGKESIASYDG 444 +RYGPVF L Q VV + + + F + + I +G Sbjct: 60 LAERYGPVFTLYLGSQRAVVVHGYKPVKEVLLDYKNEFSGRGENPGFQMHKNNGIIFNNG 119 Query: 445 SFHKYVRSFASRLFGLDSLRDVLLAEMD------------CNVTDSLAAWAAEPAIEVKD 588 S + R F+ L +LRD+ + + V +P V Sbjct: 120 STWRDTRRFS-----LTTLRDLGMGKQGNEQRIQREAHFLLEVLRKTQGQPFDPTFVVGF 174 Query: 589 AVANMVFDLTAKKLIGFSPEKSRKLRKNFDAFFQGLVS--FPLY--FPGTTFYRCIQGRK 756 A N++ D+ K + + S +L F+ F L S LY FP Y RK Sbjct: 175 APYNVISDILFHKRFDYKDQTSLRLMSLFNENFYLLSSPWIQLYNNFPDYLQYLPGSHRK 234 Query: 757 NVQKV--LKDLLKERLGAPEKR-----HGDFLDEVVDELQSGRGVIDEKFAVDLMAA--- 906 ++ V +K ER+ +K FLD ++ E+ R +D + ++ +A Sbjct: 235 LLKNVSEVKSYALERVKDHQKSLEPSCPRGFLDTMLIEMAKERHSVDPMYTLENIAVTVA 294 Query: 907 -LLFASFATVSSSLTIAMKFLSGHPNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTF 1083 LLFA T S++L + L +P V E L EE + ++ G ++ M + Sbjct: 295 DLLFAGTETTSTTLRYGLLILMKYPEVEEKLHEEIDRVI-----GPSRIPAVKDRLDMPY 349 Query: 1084 TAQVTNEISRVSNVAPG-IFRKTLTDVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTF 1260 V +EI R ++ P + + D +GY IP G +V+ + +V + + F +P F Sbjct: 350 LDAVVHEIQRFIDLLPSNLLHEATQDTVFRGYVIPKGTVVIPTLDSVLHDRQEFPEPEKF 409 Query: 1261 NPWRWQDESKKSTMLKNFMPFGGGIRLCVGAEFSRIQIALFLHTLVTKYRWKEIKGGEVQ 1440 P + +E+ K +F F G R+CVG +R+++ L L ++ + K + + Sbjct: 410 KPEHFLNENGKFKYSDHFKAFSAGKRVCVGEGLARMELFLLLAAILQHFNLKSLVDPKDI 469 Query: 1441 RISEIV-----FPEGYHIQIIPR 1494 +S I P Y + +IPR Sbjct: 470 DLSPIAIGFGKIPPRYKLCLIPR 492
>P00178:CP2B4_RABIT Cytochrome P450 2B4 - Oryctolagus cuniculus (Rabbit)| Length = 491 Score = 102 bits (255), Expect = 4e-21 Identities = 113/453 (24%), Positives = 187/453 (41%), Gaps = 38/453 (8%) Frame = +1 Query: 163 GRLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEV 342 GRLPPG LP++G Q + + +F + R ++YG VF L +PVVV + Sbjct: 28 GRLPPGPSPLPVLGNLLQMDRKGL---LRSFLRLR-EKYGDVFTVYLGSRPVVVLCGTDA 83 Query: 343 NRFIFQQEGKLFRSWYPDTANNIFGKESIASYDGSFHKYVRSFAS-------RLFGLDSL 501 R D A G+ IA D F Y FA+ R F L ++ Sbjct: 84 -----------IREALVDQAEAFSGRGKIAVVDPIFQGYGVIFANGERWRALRRFSLATM 132 Query: 502 RDV----------LLAEMDCNVTDSLAAWAA--EPAIEVKDAVANMVFDLTAKKLIGFS- 642 RD + E C V + + A + + +N++ + K + Sbjct: 133 RDFGMGKRSVEERIQEEARCLVEELRKSKGALLDNTLLFHSITSNIICSIVFGKRFDYKD 192 Query: 643 PEKSRKLRKNFDAF----------FQGLVSFPLYFPGT--TFYRCIQGRKNVQKVLKDLL 786 P R L F +F F+ F +FPGT YR +Q + + + Sbjct: 193 PVFLRLLDLFFQSFSLISSFSSQVFELFPGFLKHFPGTHRQIYRNLQEINTF--IGQSVE 250 Query: 787 KERLGAPEKRHGDFLDEVVDELQSGRGVIDEKF----AVDLMAALLFASFATVSSSLTIA 954 K R DF+D + ++ + +F + + +L FA T S++L Sbjct: 251 KHRATLDPSNPRDFIDVYLLRMEKDKSDPSSEFHHQNLILTVLSLFFAGTETTSTTLRYG 310 Query: 955 MKFLSGHPNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAP- 1131 + +P+V E +++E E ++ G+ ++ M +T V +EI R+ ++ P Sbjct: 311 FLLMLKYPHVTERVQKEIEQVI-----GSHRPPALDDRAKMPYTDAVIHEIQRLGDLIPF 365 Query: 1132 GIFRKTLTDVQVKGYTIPAGWLVM-ISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLK 1308 G+ D Q +GY IP V + A+H +P FE P TFNP + D + + Sbjct: 366 GVPHTVTKDTQFRGYVIPKNTEVFPVLSSALH-DPRYFETPNTFNPGHFLDANGALKRNE 424 Query: 1309 NFMPFGGGIRLCVGAEFSRIQIALFLHTLVTKY 1407 FMPF G R+C+G +R ++ LF T++ + Sbjct: 425 GFMPFSLGKRICLGEGIARTELFLFFTTILQNF 457
>Q6VVX0:CP2R1_HUMAN Cytochrome P450 2R1 - Homo sapiens (Human)| Length = 501 Score = 102 bits (254), Expect = 5e-21 Identities = 102/444 (22%), Positives = 188/444 (42%), Gaps = 32/444 (7%) Frame = +1 Query: 172 PPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKR-YGPVFKTSLVGQPVVVSMDAEVNR 348 PPG GLP +G + + S ++P Y ++ + YG +F L G VV +V + Sbjct: 40 PPGPPGLPFIGNIYSL---AASSELPHVYMRKQSQVYGEIFSLDLGGISTVVLNGYDVVK 96 Query: 349 FIFQQEGKLF--RSWYP---------DTANNIFGKESIASYDGSFHKYVRSFASRLFGLD 495 + ++F R P N+ +G+ + V SF +G Sbjct: 97 ECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGR----GWVDHRRLAVNSFRYFGYGQK 152 Query: 496 SLRDVLLAEMDCNVTDSLAAWAAEPAIEVKDAVANMVFDLTAKKLIG--FSPE------- 648 S +L E D++ + P + K + N V ++T + G F+ E Sbjct: 153 SFESKILEETKF-FNDAIETYKGRP-FDFKQLITNAVSNITNLIIFGERFTYEDTDFQHM 210 Query: 649 -----KSRKLRKNFDAFFQGLVSFPLYFPGTTFYRCIQGRKNVQKVLKDLL-KERLGAPE 810 ++ +L + F + P + + V L L+ K + Sbjct: 211 IELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKP 270 Query: 811 KRHGDFLDEVVDELQSGRGVIDEKFAVDLM----AALLFASFATVSSSLTIAMKFLSGHP 978 + F+D +DE+ G+ F+ + + L+ A T ++ L A+ F++ +P Sbjct: 271 QLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYP 330 Query: 979 NVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAP-GIFRKTLT 1155 N+ +++E + I+ G +W++ M +T V +E+ R N+ P GIF T Sbjct: 331 NIQGQVQKEIDLIM-----GPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSE 385 Query: 1156 DVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGI 1335 D V+GY+IP G V+ + +VH + + + DP F+P R+ D S + +PF G Sbjct: 386 DAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGR 445 Query: 1336 RLCVGAEFSRIQIALFLHTLVTKY 1407 R C+G +R+++ LF L+ ++ Sbjct: 446 RHCLGEHLARMEMFLFFTALLQRF 469
>P24470:CP2CN_RAT Cytochrome P450 2C23 - Rattus norvegicus (Rat)| Length = 494 Score = 102 bits (254), Expect = 5e-21 Identities = 120/498 (24%), Positives = 214/498 (42%), Gaps = 31/498 (6%) Frame = +1 Query: 94 LAAVVAGWLAHCVYKWTNPACSTGRLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLK 273 LA VV+ + WT + GRLPPG LP++G Q D+PA + K Sbjct: 9 LALVVSVTCLSLLSVWTKLR-TRGRLPPGPTPLPIIGNLLQLNLK----DIPASLSKLAK 63 Query: 274 RYGPVFKTSLVGQPVVVSMDAEVNRFIFQQEGKLF--RSWYPDTANNIFGKESIASYDGS 447 YGPV+ P VV +V + Q+G F R P + G I S +G Sbjct: 64 EYGPVYTLYFGTSPTVVLHGYDVVKEALLQQGDEFLGRGPLPIIEDTHKGYGLIFS-NGE 122 Query: 448 FHKYVRSFAS---RLFGLD--SLRDVLLAEMDCNVTD--SLAAWAAEPAIEVKDAVANMV 606 K +R F+ R FG+ SL + + E C V + A +P + A N++ Sbjct: 123 RWKVMRRFSLMTLRNFGMGKRSLEERVQEEARCLVEELQKTKAQPFDPTFILACAPCNVI 182 Query: 607 FDLTAKKLIGFSPEKSRKLRKNFDAFFQGLVSF--PLYFPGTTFYRCIQGR-----KNVQ 765 + ++ + L + FQ + S +Y T + + G+ K + Sbjct: 183 CSILFNDRFQYNDKTFLNLMDLLNKNFQQVNSVWCQMYNLWPTIIKYLPGKHIEFAKRID 242 Query: 766 KVLKDLLKERLGAPEK-----RHGDFLDEVVDELQSGRGVIDEKFAVDLMAA----LLFA 918 V K+ + E++ +K D++D + +++ + + +F ++ +A L A Sbjct: 243 DV-KNFILEKVKEHQKSLDPANPRDYIDCFLSKIEEEKDNLKSEFHLENLAVCGSNLFTA 301 Query: 919 SFATVSSSLTIAMKFLSGHPNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVT 1098 T S++L + L +P V + EE + ++ + + + ++ + +T V Sbjct: 302 GTETTSTTLRFGLLLLMKYPEVQAKVHEELDRVIGRHQPPSM-----KDKMKLPYTDAVL 356 Query: 1099 NEISRVSNVAPGIF-RKTLTDVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRW 1275 +EI R + P + D + + Y IP G V+ +V L+ + F +P F+P + Sbjct: 357 HEIQRYITLLPSSLPHAVVQDTKFRDYVIPKGTTVLPMLSSVMLDQKEFANPEKFDPGHF 416 Query: 1276 QDESKKSTMLKNFMPFGGGIRLCVGAEFSRIQIALFLHTLVTKYRWK---EIKGGEVQRI 1446 D++ F+PF G R CVG +R+++ LF TL+ K+ K E K +++ I Sbjct: 417 LDKNGCFKKTDYFVPFSLGKRACVGESLARMELFLFFTTLLQKFSLKTLVEPKDLDIKPI 476 Query: 1447 SE--IVFPEGYHIQIIPR 1494 + I P Y + ++PR Sbjct: 477 TTGIINLPPPYKLCLVPR 494
>P33267:CP2F2_MOUSE Cytochrome P450 2F2 - Mus musculus (Mouse)| Length = 491 Score = 102 bits (253), Expect = 7e-21 Identities = 105/442 (23%), Positives = 189/442 (42%), Gaps = 27/442 (6%) Frame = +1 Query: 163 GRLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEV 342 G+LPPG LP++G Q S D+ + K YG VF L +PV+V + Sbjct: 28 GQLPPGPKPLPILGNLLQL----RSQDLLTSLTKLSKEYGSVFTVYLGSRPVIVLSGYQT 83 Query: 343 NRFIFQQEGKLF--RSWYPDTANNIFGKESIASYDGSFHKYVRSFASRLF-----GLDSL 501 + +G+ F R YP N G IA DG K +R F+ ++ G S+ Sbjct: 84 VKEALVDKGEEFSGRGAYPVFFNFTRGN-GIAFSDGERWKILRRFSVQILRNFGMGKRSI 142 Query: 502 RDVLLAEMD--CNVTDSLAAWAAEPAIEVKDAVANMV--------FDLTAKKL---IGFS 642 + +L E V + +P + +V+N++ FD ++L I F Sbjct: 143 EERILEEGSFLLEVLRKMEGKPFDPVFILSRSVSNIICSVVFGSRFDYDDERLLTIIHFI 202 Query: 643 PEKSRKLRKNFDAFFQGLVSFPLYFPGT--TFYRCIQGRKNVQKVLKDLLKERLGAPEKR 816 + + + + + S + PG +R G K++ + + + + + Sbjct: 203 NDNFKIMSSPWGEMYNIFPSVLDWIPGPHKRLFRNFGGMKDL--IARSVREHQDSLDPNS 260 Query: 817 HGDFLDEVVDELQSGRGVIDEKFAVDLMAA----LLFASFATVSSSLTIAMKFLSGHPNV 984 DF+D + ++ + F +D + LLF TV ++L A L +P V Sbjct: 261 PRDFIDCFLTKMAQEKQDPLSHFNMDTLLMTTHNLLFGGTETVGTTLRHAFLILMKYPKV 320 Query: 985 VESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAP-GIFRKTLTDV 1161 ++EE + ++ G T E+ SM +T V +E+ R ++V P + + D Sbjct: 321 QARVQEEIDRVV-----GRSRMPTLEDRTSMPYTDAVIHEVQRFADVIPMNLPHRVTRDT 375 Query: 1162 QVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGIRL 1341 +G+ IP G V+ VH + + F+ P FNP + D++ FMPF G RL Sbjct: 376 PFRGFLIPKGTDVITLLNTVHYDSDQFKTPQEFNPEHFLDDNHSFKKSPAFMPFSAGRRL 435 Query: 1342 CVGAEFSRIQIALFLHTLVTKY 1407 C+G +R+++ ++ +++ + Sbjct: 436 CLGEPLARMELFIYFTSILQNF 457
>O54750:CP2J6_MOUSE Cytochrome P450 2J6 - Mus musculus (Mouse)| Length = 501 Score = 101 bits (252), Expect = 9e-21 Identities = 103/438 (23%), Positives = 195/438 (44%), Gaps = 26/438 (5%) Frame = +1 Query: 172 PPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVG-QPVVVSMDAEVNR 348 PPG GLP VG FQ P L + +K+YG +F +L VV++ + Sbjct: 44 PPGPWGLPFVGNIFQLDFGQPHLSIQPL----VKKYGNIFSLNLGDITSVVITGLPLIKE 99 Query: 349 FIFQQEGKLFRSWYPDTANNIFGKESIASYDGSFHKYVRSFAS---RLFGLD--SLRDVL 513 + Q E + I K + G K R FA R FGL SL + + Sbjct: 100 ALTQMEQNIMNRPLSVMQERISNKNGLIFSSGQIWKEQRRFALMTLRNFGLGKKSLEERM 159 Query: 514 LAEMDCNVTDSLAAWAAEPA---IEVKDAVANMVFDLTAKKLIGFSPEKSRKLRKNFDAF 684 E ++ +++ +P + +AV+N++ +T + + + +++ + D Sbjct: 160 QEEAS-HLVEAIREEEGKPFNPHFSINNAVSNIICSVTFGERFDYHDSRFQEMLRLLDEV 218 Query: 685 FQ---GLVS-----FPL---YFPGT--TFYRCIQGRKNVQKVLKDLLKERLGAPEKRHGD 825 ++S FP Y PG+ +R + K + D ++ E R D Sbjct: 219 MYLETTMISQLYNIFPWIMKYIPGSHQKVFRNWEKLKLFVSCMIDDHRKDWNPDEPR--D 276 Query: 826 FLDEVVDELQS---GRGVIDEKFAVDLMAALLFASFATVSSSLTIAMKFLSGHPNVVESL 996 F+D + E+ +E+ + L FA T S++L A+ +++ +P V E + Sbjct: 277 FIDAFLKEMTKYPEKTTSFNEENLICSTLDLFFAGTETTSTTLRWALLYMALYPEVQEKV 336 Query: 997 KEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAP-GIFRKTLTDVQVKG 1173 + E + ++ G K + +SM +T V +E+ R+ N+ P + R+ D + G Sbjct: 337 QAEIDRVI-----GQKRAARLADRESMPYTNAVIHEVRRMGNIIPLNVPREVAMDTNLNG 391 Query: 1174 YTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGIRLCVGA 1353 + +P G +V+ + A+H +P+ + P FNP + E+ + ++F+PF G R C+G Sbjct: 392 FHLPKGTMVLTNLTALHRDPKEWATPDVFNPEHFL-ENGQFKKRESFLPFSMGKRACLGE 450 Query: 1354 EFSRIQIALFLHTLVTKY 1407 + +R ++ +F +L+ K+ Sbjct: 451 QLARSELFIFFTSLMQKF 468
>Q4V8D1:CP2U1_RAT Cytochrome P450 2U1 - Rattus norvegicus (Rat)| Length = 530 Score = 101 bits (251), Expect = 1e-20 Identities = 122/496 (24%), Positives = 209/496 (42%), Gaps = 46/496 (9%) Frame = +1 Query: 85 LCGLAAVVAGWLAHCVYKWTNPACSTGRLPPGSMGLPLVGETFQFFKP-----------S 231 LCGLA V+ W+ W G +PPG PLVG P Sbjct: 30 LCGLA-VLLDWV------WLQRQ-RAGGIPPGPKPRPLVGNFGYLLLPRFLRLHFWLGSG 81 Query: 232 PSLDVPA--FYKQRLKR-YGPVFKTSLVGQPVVVSMDAEVNRFIFQQEGKLFRSWYPDTA 402 D Y RL R YG +F + + VVV D + R Q+ ++F Sbjct: 82 SQTDTVGRHVYLARLARVYGNIFSFFIGHRLVVVLSDFQSVREALVQQAEVFSDRPRMPL 141 Query: 403 NNIFGKES--IASYDGSFHKYVRSFAS---RLFGLDSLRDVLLAEMDCNVTDSLAAWAAE 567 +I KE + ++ G K R F+ R FGL L ++ + + A AE Sbjct: 142 ISILTKEKGIVFAHYGPIWKQQRRFSHSTLRHFGLGKL------SLEPRIIEEFAYVKAE 195 Query: 568 ----------PAIEVKDAVANMV--------FDLTAKKLIGFSPEKSRKLR--KNFDAFF 687 P + +AV+N++ FD T K+ SR L + F Sbjct: 196 MQKHGEAPFSPFPVISNAVSNIICSLCFGQRFDYTNKEFKKVLDFMSRGLEICLHSQLFL 255 Query: 688 QGLVSFPLYFPGTTFYRCIQGRKNVQKVLKDLLKERLGAPEKRHG-DFLDEVV----DEL 852 L + Y P F Q +++ LK+++KE + + + DF+D + +E Sbjct: 256 INLCPWFYYLPFGPFKELRQIERDITCFLKNIIKEHQESLDANNPQDFIDMYLLHTQEEK 315 Query: 853 QSGRGV-IDEKFAVDLMAALLFASFATVSSSLTIAMKFLSGHPNVVESLKEEHEAILKKR 1029 +G DE + ++ L A T ++SL + ++S +P V + + EE E ++ Sbjct: 316 DKCKGTNFDEDYLFYIIGDLFIAGTDTTTNSLLWCLLYMSLNPGVQKKVHEEIERVI--- 372 Query: 1030 EEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAP-GIFRKTLTDVQVKGYTIPAGWLVMI 1206 G + + M +T E+ R+S V P I T ++GY+IP G +V+ Sbjct: 373 --GRDRAPSLTDKAQMPYTEATIMEVQRLSMVVPLAIPHMTSEKTVLQGYSIPKGTVVLP 430 Query: 1207 SPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGIRLCVGAEFSRIQIALFL 1386 + ++H +P ++E P F P R+ D+ + + F+PFG G R+C+G + +++++ L Sbjct: 431 NLWSIHRDPVIWEKPDDFCPHRFLDDQGQLLKRETFIPFGIGKRVCMGEQLAKMELFLMF 490 Query: 1387 HTLVTKYRWKEIKGGE 1434 +L+ + + +G E Sbjct: 491 VSLMQSFTFALPEGSE 506
>P00182:CP2C3_RABIT Cytochrome P450 2C3 - Oryctolagus cuniculus (Rabbit)| Length = 489 Score = 101 bits (251), Expect = 1e-20 Identities = 103/446 (23%), Positives = 188/446 (42%), Gaps = 26/446 (5%) Frame = +1 Query: 163 GRLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAE- 339 G+LPPG LP+VG Q + D+ K YG +F +P VV E Sbjct: 27 GKLPPGPTPLPVVGNLLQL----ETKDINKSLSMLAKEYGSIFTLYFGMKPAVVLYGYEG 82 Query: 340 -VNRFIFQQEGKLFRSWYPDTANNIFGKESIASYDGSFHKYVRSFASRLF-----GLDSL 501 + I + E R +P + + I G K R F+ + G ++ Sbjct: 83 VIEALIDRGEEFSGRGIFP-VFDRVTKGLGIVFSSGEKWKETRRFSLTVLRNLGMGKKTI 141 Query: 502 RDVLLAEMDCNVTD--SLAAWAAEPAIEVKDAVANMVFDLTAKKLIGFSPEKSRKLRKNF 675 + + E C + A +P + N++ + + + EK + L K F Sbjct: 142 EERIQEEALCLIQALRKTNASPCDPTFLLFCVPCNVICSVIFQNRFDYDDEKFKTLIKYF 201 Query: 676 DAFFQGLVS--------FPL--YFPGT--TFYRCIQGRKNVQKVLKDLLKERLGAPEKRH 819 F+ L + FP+ Y PG+ ++ I G+ ++ +L+ + + + Sbjct: 202 HENFELLGTPWIQLYNIFPILHYLPGSHRQLFKNIDGQ--IKFILEKVQEHQESLDSNNP 259 Query: 820 GDFLDEVVDELQSGRGVIDEKFAVDLMAALLFASFA----TVSSSLTIAMKFLSGHPNVV 987 DF+D + +++ + +F +D + ++ F+ T S++L A+ L HP + Sbjct: 260 RDFVDHFLIKMEKEKHKKQSEFTMDNLITTIWDVFSAGTDTTSNTLKFALLLLLKHPEIT 319 Query: 988 ESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAPGIFRKTLT-DVQ 1164 ++EE E ++ G ++ M +T V +EI R ++ P +T D++ Sbjct: 320 AKVQEEIEHVI-----GRHRSPCMQDRTRMPYTDAVMHEIQRYVDLVPTSLPHAVTQDIE 374 Query: 1165 VKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGIRLC 1344 GY IP G ++ S +V + + F +P F+P + DES FMPF G R C Sbjct: 375 FNGYLIPKGTDIIPSLTSVLYDDKEFPNPEKFDPGHFLDESGNFKKSDYFMPFSAGKRAC 434 Query: 1345 VGAEFSRIQIALFLHTLVTKYRWKEI 1422 VG +R+++ L L T++ + K + Sbjct: 435 VGEGLARMELFLLLTTILQHFTLKPL 460
>Q6VVW9:CP2R1_MOUSE Cytochrome P450 2R1 - Mus musculus (Mouse)| Length = 501 Score = 100 bits (250), Expect = 1e-20 Identities = 108/451 (23%), Positives = 193/451 (42%), Gaps = 39/451 (8%) Frame = +1 Query: 172 PPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKR-YGPVFKTSLVGQPVVVSMDAEVNR 348 PPG LP VG + S D+P Y ++ R YG +F L G VV +V + Sbjct: 40 PPGPPRLPFVGNICSL---ALSADLPHVYMRKQSRVYGEIFSLDLGGISTVVLNGYDVVK 96 Query: 349 FIFQQEGKLF--RSWYP---------DTANNIFGKESIASYD---GSFHKY---VRSFAS 477 + ++F R P N+ +G+ I SFH + +SF S Sbjct: 97 ECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRGWIDHRRLAVNSFHYFGSGQKSFES 156 Query: 478 RLFGLDSLRDVLLAEMDCNVTDSLAAWAAEPAIEVKDAVANMVFDLTAKKLIG----FSP 645 ++ E ++ D++ + P ++K + N V ++T L G + Sbjct: 157 KIL-----------EETWSLIDAIETYKGGP-FDLKQLITNAVSNITNLILFGERFTYED 204 Query: 646 EKSRKLRKNFDAFFQGLVSFPLYF----------PGTTFYRCIQGRKNVQKVLKDLLKER 795 + + + F + S P++ P R + V L L+ E+ Sbjct: 205 TDFQHMIELFSENVELAASAPVFLYNAFPWIGILPFGKHQRLFRNADVVYDFLSRLI-EK 263 Query: 796 LGAPEKRH--GDFLDEVVDELQSGRG----VIDEKFAVDLMAALLFASFATVSSSLTIAM 957 K H F+D +DE+ G+ ++ + + L+ A T ++ L A+ Sbjct: 264 AAVNRKPHLPHHFVDAYLDEMDQGQNDPLSTFSKENLIFSVGELIIAGTETTTNVLRWAI 323 Query: 958 KFLSGHPNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAP-G 1134 F++ +PN+ + +E + I+ G +WE M +T V +E+ R N+ P G Sbjct: 324 LFMALYPNIQGQVHKEIDLIV-----GHNRRPSWEYKCKMPYTEAVLHEVLRFCNIVPLG 378 Query: 1135 IFRKTLTDVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNF 1314 IF T D V+GY+IP G V+ + +VH + + ++DP F P R+ D + T + Sbjct: 379 IFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWKDPDMFYPERFLDSNGYFTKKEAL 438 Query: 1315 MPFGGGIRLCVGAEFSRIQIALFLHTLVTKY 1407 +PF G R C+G + +R+++ LF +L+ ++ Sbjct: 439 IPFSLGRRHCLGEQLARMEMFLFFTSLLQQF 469
>Q01361:CP2DE_BOVIN Cytochrome P450 2D14 - Bos taurus (Bovine)| Length = 500 Score = 100 bits (250), Expect = 1e-20 Identities = 118/488 (24%), Positives = 214/488 (43%), Gaps = 45/488 (9%) Frame = +1 Query: 166 RLPPGSMGLPLVGETFQ--FFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAE 339 R PPG LP++G Q F P PS + Q +R+G VF V PVVV Sbjct: 35 RYPPGPTPLPVLGNLLQVDFEDPRPS------FNQLRRRFGNVFSLQQVWTPVVV----- 83 Query: 340 VNRFIFQQEGKLFRSWYPDTANNI---------FGKES----IASYDGSFHKYVRSFASR 480 +N +E ++RS DTA+ +G + +A Y ++ + R + Sbjct: 84 LNGLAAVREALVYRS--QDTADRPPPAVYEHLGYGPRAEGVILARYGDAWREQRRFSLTT 141 Query: 481 L--FGLD--SLRDVLLAEMDCNVTDSLAAWAAEPAIEV---KDAVANMVFDLTAKKLIGF 639 L FGL SL + E C + + A A P + AV+N++ LT + Sbjct: 142 LRNFGLGKKSLEQWVTEEASC-LCAAFADQAGRPFSPMDLLNKAVSNVIASLTFGCRFEY 200 Query: 640 SPEKSRKL--------RKNFDAFFQGLVSFP--LYFPGTTFYRCIQGRKNVQKVLKDLLK 789 + + KL ++ F+ + + + P L PG R +K ++ +L+ Sbjct: 201 NDPRIIKLLDLTEDGLKEEFNLVRKVVEAVPVLLSIPGLAA-RVFPAQKAFMALIDELIA 259 Query: 790 ERLGA--PEKRHGDFLDEVVDELQSGRGVIDEKFAVD----LMAALLFASFATVSSSLTI 951 E+ P + D +DE++ +G + F + ++A L A T S++L Sbjct: 260 EQKMTRDPTQPPRHLTDAFLDEVKEAKGNPESSFNDENLRLVVADLFSAGMVTTSTTLAW 319 Query: 952 AMKFLSGHPNVVESLKEEHEAILK--KREEGAKSGITWEEYKSMTFTAQVTNEISRVSNV 1125 A+ + HP+V +++E + ++ +R E + M FT V +E+ R +++ Sbjct: 320 ALLLMILHPDVQRRVQQEIDEVIGQVRRPEMGDQAL-------MPFTVAVVHEVQRFADI 372 Query: 1126 AP-GIFRKTLTDVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTM 1302 P G+ T D++V+G+ IP G ++ + +V + ++E P F+P + D + Sbjct: 373 VPLGLPHMTSRDIEVQGFHIPKGTTLITNLSSVLKDETVWEKPFRFHPEHFLDAQGRFVK 432 Query: 1303 LKNFMPFGGGIRLCVGAEFSRIQIALFLHTLVTKYRWKEIKG----GEVQRISEIVFPEG 1470 + F+PF G R C+G +R+++ LF +L+ + + G E + +V P Sbjct: 433 QEAFIPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPAGQPRPSEHGVFAFLVTPAP 492 Query: 1471 YHIQIIPR 1494 Y + +PR Sbjct: 493 YQLCAVPR 500
>P11371:CP2C4_RABIT Cytochrome P450 2C4 - Oryctolagus cuniculus (Rabbit)| Length = 487 Score = 100 bits (250), Expect = 1e-20 Identities = 114/475 (24%), Positives = 201/475 (42%), Gaps = 32/475 (6%) Frame = +1 Query: 163 GRLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEV 342 G+LPPG P++G Q S + F + RYGPVF L +P VV + Sbjct: 27 GKLPPGPTPFPIIGNILQIDVKDISKSLTKFSE----RYGPVFTVYLGMKPTVVLHGYKA 82 Query: 343 NRFIFQQEGKLF--RSWYPDTANNIFGKESIASYDGSFHKYVRSFAS---RLFGLD--SL 501 + G+ F R +P A + I + + K +R F+ R FG+ S+ Sbjct: 83 VKEALVDLGEEFAGRGHFP-IAEKVNKGLGIVFTNANTWKEMRRFSLMTLRNFGMGKRSI 141 Query: 502 RDVLLAEMDCNVTD--SLAAWAAEPAIEVKDAVANMVFDLTAKKLIGFSPEKSRKLRKNF 675 D + E C V + A +P + A N++ + + E+ KL + Sbjct: 142 EDRVQEEARCLVEELRKTNALPCDPTFILGCAPCNVICSVILHNRFDYKDEEFLKLMERL 201 Query: 676 DAFFQGLVS--------FPL---YFPGT--TFYRCIQGRKNVQKVLKDLLKERLGAPEKR 816 + + L S FP YFPG T + KN +++ + + + Sbjct: 202 NENIRILSSPWLQVYNNFPALLDYFPGIHKTLLKNADYTKNF--IMEKVKEHQKLLDVNN 259 Query: 817 HGDFLDEVVDELQSGRGVIDEKFAVDLMAALLFASFA----TVSSSLTIAMKFLSGHPNV 984 DF+D + +++ + +F + + +F F T S++L ++ L HP V Sbjct: 260 PRDFIDCFLIKMEKENNL---EFTLGSLVIAVFDLFGAGTETTSTTLRYSLLLLLKHPEV 316 Query: 985 VESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAPGIFRKTLT-DV 1161 ++EE E ++ G ++ M +T V +EI R ++ P +T DV Sbjct: 317 AARVQEEIERVI-----GRHRSPCMQDRSHMPYTDAVIHEIQRFIDLLPTNLPHAVTRDV 371 Query: 1162 QVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGIRL 1341 + + Y IP G ++ S +V + + F +P F+P + DES FMPF G R+ Sbjct: 372 KFRNYFIPKGTDIITSLTSVLHDEKAFPNPKVFDPGHFLDESGNFKKSDYFMPFSAGKRM 431 Query: 1342 CVGAEFSRIQIALFLHTLVTKYRWKEIKGGEVQRISEIV-----FPEGYHIQIIP 1491 CVG +R+++ LFL +++ ++ + + + I+ +V P Y + IP Sbjct: 432 CVGEGLARMELFLFLTSILQNFKLQSLVEPKDLDITAVVNGFVSVPPSYQLCFIP 486
>Q64148:CP3AA_MESAU Cytochrome P450 3A10 - Mesocricetus auratus (Golden hamster)| Length = 503 Score = 100 bits (249), Expect = 2e-20 Identities = 106/445 (23%), Positives = 193/445 (43%), Gaps = 34/445 (7%) Frame = +1 Query: 175 PGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEVNRFI 354 PG LP G + + D + K+YG ++ PV+ D E+ + + Sbjct: 39 PGPKPLPFFGTILGYHDGTWKFDETCY-----KKYGKIWGFYDGRVPVLAIADPEIIKTV 93 Query: 355 FQQEGKLFRSWYPDTANNI------FGKESIASYDGSFHKYVRSFASRLFGLDSLRDV-- 510 L + Y + N F K+SI K +R+ S F L+++ Sbjct: 94 ------LVKECYSNFTNRRSFGPVGFMKKSITISKDEEWKRLRTLLSPAFTSGKLKEMFP 147 Query: 511 LLAEMDCNVTDSLAAWAAE-PAIEVKDAVANMVFDLTAKKLIGFS------PE-----KS 654 ++ + + +L + + +K+ + D+ G + PE K+ Sbjct: 148 IIGQYGDTLVKNLRREEEKGKPVNMKEILGAYSMDVITGTSFGVNVDSLNNPEDPFVQKA 207 Query: 655 RKLRKN--FDAFFQGLVSFPLYFPGTTFYRCI-------QGRKNVQKVLKDLLKERLGAP 807 RK+ K FD F ++ FP TT Y + Q +K + + K RL + Sbjct: 208 RKILKFNFFDPFILSIILFPFL---TTIYDLLRFSIFPRQSTNFFKKFITTMKKNRLHSN 264 Query: 808 EKRHGDFLDEVVDELQSGRGVIDEKFAVDL-MAA----LLFASFATVSSSLTIAMKFLSG 972 +K DF +++ Q+ +G +K DL MAA +FA + + S+S+ + + L+ Sbjct: 265 QKTRMDFF-QLMMNTQNSKGKESQKALSDLEMAAQAIIFIFAGYESTSTSICLVLYELAT 323 Query: 973 HPNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAPGIFRKTL 1152 HP+V + L +E ++ L K+ +T++ M + V NE R+ +A + R + Sbjct: 324 HPDVQKKLHDEIDSALPN-----KAPVTYDVLMGMEYLDMVINEGLRLYPIANRLERISK 378 Query: 1153 TDVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGG 1332 V++ G IP G VM+ +H +PE + +P F P R+ E+K S +MPFG G Sbjct: 379 KAVEINGLFIPKGITVMVPTYPLHRDPEYWPEPEEFRPERFSKENKGSIDPYVYMPFGNG 438 Query: 1333 IRLCVGAEFSRIQIALFLHTLVTKY 1407 R C+G F+ + + L + +++ + Sbjct: 439 PRNCIGMRFALLSMKLAVVSVLQNF 463
>P20814:CP2CD_RAT Cytochrome P450 2C13, male-specific - Rattus norvegicus (Rat)| Length = 490 Score = 100 bits (249), Expect = 2e-20 Identities = 104/452 (23%), Positives = 187/452 (41%), Gaps = 27/452 (5%) Frame = +1 Query: 148 PACSTGRLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVS 327 P+ G+LPPG LP++G FQ D+ K YGPV+ + QP VV Sbjct: 22 PSSGRGKLPPGPTPLPIIGNFFQV----DMKDIRQSLTNFSKTYGPVYTLYVGSQPTVVL 77 Query: 328 MDAEVNRFIFQQEGKLF--RSWYPDTANNIFGKESIASYDGSFHKYVRSFASRLF----- 486 E + G+ F R P + + IA G+ K R F + Sbjct: 78 HGYEALKEALVDHGEEFSGRGRLP-ICEKVAKGQGIAFSHGNVWKATRHFTVKTLRNLGM 136 Query: 487 GLDSLRDVLLAEMDCNVTD--SLAAWAAEPAIEVKDAVANMV--------FDLTAKKLIG 636 G ++ D + E V + +P + A N++ FD K + Sbjct: 137 GKGTIEDKVQEEAKWLVKELKKTNGSPCDPQFIMGCAPGNVICSIILQNRFDYEDKDFLN 196 Query: 637 FSPEKSRKLRKNFDAFFQGLVSFPL---YFPGT-TFYRCIQGRKNVQKVLKDLLKERLGA 804 + + ++ Q FP+ Y PG Y + ++ L + +KE + Sbjct: 197 LIEKVNEAVKIISSPGIQVFNIFPILLDYCPGNHNIY--FKNHTWLKSYLLEKIKEHEES 254 Query: 805 PEKRHG-DFLDEVVDELQSGRGVIDEKFAVDLMAA----LLFASFATVSSSLTIAMKFLS 969 + + DF+D + E + ++ +A L FA TVSS++ A+ L Sbjct: 255 LDVSNPRDFIDYFLIERNQENANQWMNYTLEHLAIMVTDLFFAGIETVSSTMRFALLLLM 314 Query: 970 GHPNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAP-GIFRK 1146 +P+V ++EE + ++ G ++ M +T + +E+ R ++ P G+ + Sbjct: 315 KYPHVTAKVQEEIDHVI-----GRHRSPCMQDRSHMPYTNAMVHEVQRYIDIGPNGLLHE 369 Query: 1147 TLTDVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFG 1326 D + + Y IP G V+ S +V + + F +P F+P + DE+ F+PF Sbjct: 370 VTCDTKFRNYFIPKGTAVLTSLTSVLHDSKEFPNPEMFDPGHFLDENGNFKKSDYFIPFS 429 Query: 1327 GGIRLCVGAEFSRIQIALFLHTLVTKYRWKEI 1422 G R+C+G +R+++ LFL T++ ++ K + Sbjct: 430 AGKRMCLGESLARMELFLFLTTILQNFKLKSL 461
>P00180:CP2C1_RABIT Cytochrome P450 2C1 - Oryctolagus cuniculus (Rabbit)| Length = 490 Score = 100 bits (249), Expect = 2e-20 Identities = 108/446 (24%), Positives = 193/446 (43%), Gaps = 26/446 (5%) Frame = +1 Query: 163 GRLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEV 342 G+LPPG P++G Q D+ + + + YGPVF L +P VV + Sbjct: 27 GKLPPGPTPFPILGNILQI----GIQDISKSFTKLSEVYGPVFTVYLGMKPTVVIHGYDA 82 Query: 343 NRFIFQQEGKLF--RSWYPDTANNIFGKESIASYDGSFHKYVRSFAS---RLFGLD--SL 501 + G+ F R +P TA G + S +G K R F+ R FG+ S+ Sbjct: 83 VKEALVDLGEEFSGRIVFPLTAKINKGYGIVFS-NGKRWKETRRFSLMTLRDFGMGKRSI 141 Query: 502 RDVLLAEMDCNVTD--SLAAWAAEPAIEVKDAVANMVFDLTAKKLIGFSPEK----SRKL 663 D + E C V + P + A N++ + + ++ + KL Sbjct: 142 EDRVQEEARCLVEELRKTNGSPCNPTFILGAAPCNVICSVIFQNRFDYTDQDFLSLMGKL 201 Query: 664 RKNF----DAFFQGLVSFPL---YFPGTTFYRCIQGRKNVQKVLKDLLKERLGAPEKRHG 822 +NF + Q +FP+ Y PG+ + ++ ++ + + +KE + + Sbjct: 202 NENFKILNSPWVQMCNNFPILIDYLPGS-HNKILRNNIYIRNYVLEKIKEHQETLDINNP 260 Query: 823 -DFLDEVVDELQSGRGVIDEKFAVDLMAALLFASFA----TVSSSLTIAMKFLSGHPNVV 987 DF+D + +++ + +F ++ + L F T S++L + L HP V+ Sbjct: 261 RDFIDCFLIKMEQEKDNQQSEFTIENLMTTLSDVFGAGTETTSTTLRYGLLLLMKHPEVI 320 Query: 988 ESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAPG-IFRKTLTDVQ 1164 ++EE E ++ G ++ M +T +EI R N+ P + R T +V+ Sbjct: 321 AKVQEEIERVI-----GRHRSPCMQDRSRMPYTDATVHEIQRYINLIPNNVPRATTCNVK 375 Query: 1165 VKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGIRLC 1344 + Y IP G V+ S ++ N + F +P F+P + D S K FMPF G R+C Sbjct: 376 FRSYLIPKGTAVITSLTSMLYNDKEFPNPDRFDPGHFLDASGKFRKSDYFMPFSTGKRVC 435 Query: 1345 VGAEFSRIQIALFLHTLVTKYRWKEI 1422 VG +R+++ LFL ++ + K + Sbjct: 436 VGEVLARMELFLFLTAILQNFTPKPL 461
>P12789:CP2B5_RABIT Cytochrome P450 2B5 - Oryctolagus cuniculus (Rabbit)| Length = 491 Score = 100 bits (249), Expect = 2e-20 Identities = 113/453 (24%), Positives = 184/453 (40%), Gaps = 38/453 (8%) Frame = +1 Query: 163 GRLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEV 342 GRLPPG LP++G Q + + +F + R ++YG VF L +PVVV + Sbjct: 28 GRLPPGPPPLPVLGNLLQMDRKGL---LRSFLRLR-EKYGDVFTVYLGSRPVVVLCGTDA 83 Query: 343 NRFIFQQEGKLFRSWYPDTANNIFGKESIASYDGSFHKYVRSFAS-------RLFGLDSL 501 R D A G+ IA D F Y FA+ R F L ++ Sbjct: 84 -----------IREALVDQAEAFSGRGKIAVVDPIFQGYGVFFANGEHWRALRRFSLATM 132 Query: 502 RDV----------LLAEMDCNVTDSLAAWAA--EPAIEVKDAVANMVFDLTAKKLIGFS- 642 RD + E C V + + A + + +N++ + K + Sbjct: 133 RDFGMGKRSVEERIQEEARCLVEELRKSKGALLDNTLLFHSVTSNIICSIVFGKRFDYKD 192 Query: 643 PEKSRKLRKNFDAF----------FQGLVSFPLYFPGT--TFYRCIQGRKNVQKVLKDLL 786 P R L F +F F+ F +FPGT YR +Q + + + Sbjct: 193 PVFLRLLDLFFQSFSLISSFSSQVFELFPGFLKHFPGTHRQIYRNLQEINTF--IGQTVE 250 Query: 787 KERLGAPEKRHGDFLDEVVDELQSGRGVIDEKF----AVDLMAALLFASFATVSSSLTIA 954 K R DF+D + ++ + +F + + L FA T S++L Sbjct: 251 KHRATLDPSNPRDFIDVYLLRMEKDKSDPSSEFHHRNLILTVLTLFFAGTETTSTTLRYG 310 Query: 955 MKFLSGHPNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAP- 1131 + +P+V E +++E E ++ G+ ++ M +T V +EI R+ ++ P Sbjct: 311 FLLMLKYPHVTERVQKEIEQVI-----GSHRPPALDDRAKMPYTDAVIHEIQRLGDLVPF 365 Query: 1132 GIFRKTLTDVQVKGYTIPAGWLVM-ISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLK 1308 G D Q +GY IP V + A+H +P FE P TFNP + D + Sbjct: 366 GAPHMVTKDTQFRGYVIPKNTEVFPVLSSALH-DPRYFETPNTFNPGHFLDADGALKRNE 424 Query: 1309 NFMPFGGGIRLCVGAEFSRIQIALFLHTLVTKY 1407 FMPF G R+C+G +R ++ LF T++ + Sbjct: 425 GFMPFSLGKRICLGEGIARTELFLFFTTILQNF 457
>P95099:CP136_MYCTU Putative cytochrome P450 136 - Mycobacterium tuberculosis| Length = 492 Score = 100 bits (248), Expect = 3e-20 Identities = 104/436 (23%), Positives = 177/436 (40%), Gaps = 11/436 (2%) Frame = +1 Query: 136 KWTNPACSTGRLPP-GSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQ 312 K P +G P G GLP++G + + P + YK + GPV Sbjct: 44 KLAEPPPGSGLKPVVGDAGLPILGHMIEMLRGGPDY-LMFLYKTK----GPVVFGDSAVL 98 Query: 313 PVVVSMDAEVNRFIFQQEGKLF--RSWYPDTANNIFGKESIASYDGSFHKYVRSFASRLF 486 P V ++ + + I+ K + + W P F + D H + R F Sbjct: 99 PGVAALGPDAAQVIYSNRNKDYSQQGWVPVIGP--FFHRGLMLLDFEEHMFHRRIMQEAF 156 Query: 487 GLDSLRDVLLAEMDCNVTDSLAA-WAAEPA-IEVKDAVANMVFDLTAKKLIGFSPEKSRK 660 L L +MD V+ +A W A V A+ + D+ + +G P + Sbjct: 157 VRSRLAGYL-EQMDRVVSRVVADDWVVNDARFLVYPAMKALTLDIASMVFMGHEPGTDHE 215 Query: 661 LRKNFDAFFQ-----GLVSFPLYFPGTTFYRCIQGRKNVQKVLKDLLKERLGAPEKRHGD 825 L + F G P T++R ++ R+ ++ +KER E D Sbjct: 216 LVTKVNKAFTITTRAGNAVIRTSVPPFTWWRGLRARELLENYFTARVKERR---EASGND 272 Query: 826 FLDEVVDELQSGRGVIDEKFAVDLMAALLFASFATVSSSLTIAMKFLSGHPNVVESLKEE 1005 L + + V+ M L+ A+ T +S+ T L+ HP + ++E Sbjct: 273 LLTVLCQTEDDDGNRFSDADIVNHMIFLMMAAHDTSTSTATTMAYQLAAHPEWQQRCRDE 332 Query: 1006 HEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAPGIFRKTLTDVQVKGYTIP 1185 + + +G + E+ +S+ V NE R+ R+T+ D ++ GY +P Sbjct: 333 SD----RHGDGPLDIESLEQLESLDL---VMNESIRLVTPVQWAMRQTVRDTELLGYYLP 385 Query: 1186 AGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLK-NFMPFGGGIRLCVGAEFS 1362 G V+ P H PE++ DPLTF+P R+ + + + F PFGGG+ C+G F Sbjct: 386 KGTNVIAYPGMNHRLPEIWTDPLTFDPERFTEPRNEHKRHRYAFTPFGGGVHKCIGMVFD 445 Query: 1363 RIQIALFLHTLVTKYR 1410 +++I LH L+ +YR Sbjct: 446 QLEIKTILHRLLRRYR 461
>Q9UVC3:CP51_CUNEL Cytochrome P450 51 - Cunninghamella elegans| Length = 512 Score = 99.8 bits (247), Expect = 3e-20 Identities = 98/468 (20%), Positives = 190/468 (40%), Gaps = 36/468 (7%) Frame = +1 Query: 172 PPGSMGL-PLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEVNR 348 PP L P++G QF ++ AF ++ K+YG VF ++VG+ V V + A+ N+ Sbjct: 46 PPNVFSLIPVLGNAVQF-----GMNPVAFLQECQKKYGDVFTFTMVGKRVTVCLGADGNQ 100 Query: 349 FIFQQEGKLFRSW--YPDTANNIFGKESIASYDGSFHKYVRSFASRLFGLDSLRDVLLAE 522 F+F + L + Y +FG + + + + F D R + Sbjct: 101 FVFNSKQNLSSAAEAYNHMTKYVFGPDVVYDAPHAVFMEQKKFIKAGLNSDCFRQHV--P 158 Query: 523 MDCNVTDSLAAWAAEPA--IEVKDAVANMVFDLTAKKLIGFSPEKS-----RKLRKNFDA 681 M T+ +P IE + +++ ++ L+G S KL + D Sbjct: 159 MIVQETEEFFKKFNKPTGFIEAYETFGSLIIYTASRCLMGKEIRASLDGNVAKLYYDLDQ 218 Query: 682 FFQGLVSFPLYFPGTTFYRCIQGRKNVQKVLKDLLKERLGAPEKRHGDFLDEVVDELQSG 861 F+ + P ++ R K + + +++ R + + D L ++D Sbjct: 219 GFKPINFIFPNLPLPSYRRRDVACKKMADLYSSIIQRRKDEKDNNNADLLQALMDATYKD 278 Query: 862 RGVIDEKFAVDLMAALLFASFATVSSSLTIAMKFLSGHPNVVESLKEEHEAILKKREEGA 1041 I + +M A+LF T +++ + L+ P+++++L+EE L Sbjct: 279 GTHIPDHHIAGMMIAVLFGGQHTSATTSAWTILELANRPDIIKALREEQIEKLGS----L 334 Query: 1042 KSGITWEEYKSMTFTAQVTNEISRVSNVAPGIFRKTLTDVQV---KGYTIPAGWLVMISP 1212 K+ +T++ K + E R+ + R+ + D V G IP G + +P Sbjct: 335 KADLTFDNLKDLPLLEAAIRETLRLHPPIFQMMRRVVADKIVYEKNGMEIPKGNFICAAP 394 Query: 1213 MAVHLNPELFEDPLTFNPWRWQDESKKSTMLKN--------------------FMPFGGG 1332 ++P F +P T+NP+RW +++ L+ F+PFG G Sbjct: 395 GVTQVDPTYFNEPTTYNPYRWIEKTDPVHQLEQGDDANIDYGFGAVGISSKSPFLPFGAG 454 Query: 1333 IRLCVGAEFSRIQIALFLHTLVTKYRWKEIKGGEVQR---ISEIVFPE 1467 C+G +F +Q+ + T + + + ++ G V + S +V PE Sbjct: 455 RHRCIGEQFGYLQLKTVISTFIRTFDF-DLDGKSVPKSDYTSMVVVPE 501
>P00176:CP2B1_RAT Cytochrome P450 2B1 - Rattus norvegicus (Rat)| Length = 491 Score = 99.8 bits (247), Expect = 3e-20 Identities = 115/457 (25%), Positives = 197/457 (43%), Gaps = 40/457 (8%) Frame = +1 Query: 157 STGRLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDA 336 S G PPG LPL+G Q + + + Q ++YG VF L +PVV+ Sbjct: 26 SRGNFPPGPRPLPLLGNLLQLDRGG----LLNSFMQLREKYGDVFTVHLGPRPVVMLCGT 81 Query: 337 EVNRFIFQQEGKLFRSWYPDTANNIFGKESIASYDGSFHKYVRSFAS-------RLFGLD 495 + + A + G+ +IA + F +Y FA+ R F L Sbjct: 82 DT-----------IKEALVGQAEDFSGRGTIAVIEPIFKEYGVIFANGERWKALRRFSLA 130 Query: 496 SLRDV----------LLAEMDCNVTDSLAAWAA--EPAIEVKDAVANMVFDLTAKKLIGF 639 ++RD + E C V + + A +P + AN++ + + + Sbjct: 131 TMRDFGMGKRSVEERIQEEAQCLVEELRKSQGAPLDPTFLFQCITANIICSIVFGERFDY 190 Query: 640 SPEKSRKLRKNFDAFFQGLVSFPL-----------YFPGTTFYRCIQGRKNVQKVLKDL- 783 + + +L + F F L SF YFPG +R I KN+Q++L + Sbjct: 191 TDRQFLRLLELFYRTFSLLSSFSSQVFEFFSGFLKYFPGA--HRQIS--KNLQEILDYIG 246 Query: 784 ---LKERLGAPEKRHGDFLDEVVDELQSGRGVIDEKFAVD-LMAALLFASFA-TVSSSLT 948 K R DF+D + ++ + +F + LM +LL FA T +SS T Sbjct: 247 HIVEKHRATLDPSAPRDFIDTYLLRMEKEKSNHHTEFHHENLMISLLSLFFAGTETSSTT 306 Query: 949 IAMKFLS--GHPNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSN 1122 + FL +P+V E +++E + ++ G+ T ++ M +T V +EI R S+ Sbjct: 307 LRYGFLLMLKYPHVAEKVQKEIDQVI-----GSHRLPTLDDRSKMPYTDAVIHEIQRFSD 361 Query: 1123 VAP-GIFRKTLTDVQVKGYTIPAGWLVM-ISPMAVHLNPELFEDPLTFNPWRWQDESKKS 1296 + P G+ + D +GY +P V I A+H +P+ F+ P +FNP + D + Sbjct: 362 LVPIGVPHRVTKDTMFRGYLLPKNTEVYPILSSALH-DPQYFDHPDSFNPEHFLDANGAL 420 Query: 1297 TMLKNFMPFGGGIRLCVGAEFSRIQIALFLHTLVTKY 1407 + FMPF G R+C+G +R ++ LF T++ + Sbjct: 421 KKSEAFMPFSTGKRICLGEGIARNELFLFFTTILQNF 457
>Q0IIF9:CP2U1_BOVIN Cytochrome P450 2U1 - Bos taurus (Bovine)| Length = 543 Score = 99.4 bits (246), Expect = 4e-20 Identities = 98/404 (24%), Positives = 181/404 (44%), Gaps = 27/404 (6%) Frame = +1 Query: 277 YGPVFKTSLVGQPVVVSMDAEVNRFIFQQEGKLF--RSWYPDTANNIFGKESIASYDGSF 450 YG +F + VVV D R Q+ ++F R P T+ GK + ++ G Sbjct: 114 YGNIFSFLIGHYLVVVLNDFHSVREALVQQAEVFSDRPRVPLTSIMTKGKGIVFAHYGPV 173 Query: 451 HKYVRSFAS---RLFGLDSLR-DVLLAEMDCNVTDSLAAWAAEPAIE---VKDAVANMV- 606 + R F+ R FGL L + + E V + + P V +AV+N++ Sbjct: 174 WRQQRKFSHSTLRHFGLGKLSLEPKIIEEFRYVKEEMQKHGDAPFNPFPIVNNAVSNIIC 233 Query: 607 -------FDLTA---KKLIGFSPEKSRKLRKNFDAFFQGLVSFPLYFPGTTFYRCIQGRK 756 FD T K+++ F ++ ++ N + S+ Y P F Q K Sbjct: 234 SLCFGRRFDYTNSEFKQMLNFM-SRALEVCLNTQLLLVNICSWLYYLPFGPFKELRQIEK 292 Query: 757 NVQKVLKDLLKE-RLGAPEKRHGDFLDEVV-----DELQSGRGVIDEKFAVDLMAALLFA 918 ++ LK ++K+ R + DF+D + ++ + DE + ++ L A Sbjct: 293 DLTLFLKKIIKDHRESLDVENPQDFIDMYLLHVEEEKKNNSNSGFDEDYLFYIIGDLFIA 352 Query: 919 SFATVSSSLTIAMKFLSGHPNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVT 1098 T ++SL + ++S HPN+ E + EE ++ GA + + M +T Sbjct: 353 GTDTTTNSLLWCLLYMSLHPNIQEKIHEEIARVI-----GADRAPSLTDKAQMPYTEATI 407 Query: 1099 NEISRVSNVAP-GIFRKTLTDVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRW 1275 E+ R+S V P I T ++G+TIP G +++ + +VH +P ++E P F P R+ Sbjct: 408 MEVQRLSTVVPLSIPHMTSEKTVLQGFTIPKGTIILPNLWSVHRDPAIWEKPNDFYPDRF 467 Query: 1276 QDESKKSTMLKNFMPFGGGIRLCVGAEFSRIQIALFLHTLVTKY 1407 D+ + + F+PFG G R+C+G + +++++ L +L+ + Sbjct: 468 LDDQGQLIKKETFIPFGIGKRVCMGEQLAKMELFLMFVSLMQSF 511
>Q9MZY0:CP2E1_CANFA Cytochrome P450 2E1 - Canis familiaris (Dog)| Length = 494 Score = 99.4 bits (246), Expect = 4e-20 Identities = 114/487 (23%), Positives = 197/487 (40%), Gaps = 39/487 (8%) Frame = +1 Query: 157 STGRLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDA 336 S +LPPG LP++G Q +VP + ++YGPVF L Q VV Sbjct: 28 SRWKLPPGPFPLPIIGNILQV----DIKNVPKSLAKLAEQYGPVFTLYLGSQRTVVLHGY 83 Query: 337 EVNRFIFQQEGKLFRSWYPDTANNIFGKESIASYDG------SFHKYVRSFASRLFGLDS 498 + + + D N++ G+ + ++ +F+ +R L + Sbjct: 84 KAVKEVLL-----------DHKNDLSGRGEVFAFQSHKDRGITFNNGPGWKDTRRLSLST 132 Query: 499 LRDVLLAE------MDCNVTDSLAAWAA------EPAIEVKDAVANMVFDLTAKKLIGFS 642 LRD + + + + L A +P + A N++ D+ K +S Sbjct: 133 LRDYGMGKRGNEERIQREIPFLLEALRGTRGQPFDPTFLLGFAPFNVIADILFHKHFDYS 192 Query: 643 PEKSRKLRK----NFDAFFQGLVSFPLYFPGTTFYRCIQGRKNVQKV--LKDLLKERLGA 804 + +++K NF G + FP Y RK ++ V LKD ER+ Sbjct: 193 DQTGLRIQKLFNENFHLLSTGWLQLYNIFPSYLHYLPGSHRKVLRNVAELKDYSLERVKE 252 Query: 805 PEKR-----HGDFLDEVVDELQSGRGVIDEKFAVDLMAA----LLFASFATVSSSLTIAM 957 ++ DF D ++ ELQ R + + +D +A L FA T S++L + Sbjct: 253 HQESLDPTCSRDFTDCLLQELQKERYGTEPWYTLDNIAVTVADLFFAGTETTSTTLRYGL 312 Query: 958 KFLSGHPNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAPGI 1137 L +P V E L EE + ++ G ++ M + V +EI R ++ P Sbjct: 313 LILMKYPEVEEKLHEEIDRVI-----GPSRVPAIKDRLEMPYMDAVVHEIQRFIDLLPSN 367 Query: 1138 FRKTLT-DVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNF 1314 D +GY IP G +V+ + +V + + F DP F P + +E+ K F Sbjct: 368 LPHVANQDTMFRGYVIPKGTVVIPTLDSVLFDKQEFPDPEKFKPEHFLNENGKFKYSDYF 427 Query: 1315 MPFGGGIRLCVGAEFSRIQIALFLHTLVTKYRWKEIKGGEVQRISEIV-----FPEGYHI 1479 F G R+CVG +R+++ LFL ++ + K + + +S P Y + Sbjct: 428 KAFSAGKRVCVGEGLARMELFLFLSAILQHFNLKSLVDPKDIDLSPCTIGFAKIPPHYKL 487 Query: 1480 QIIPREG 1500 ++PR G Sbjct: 488 CVVPRSG 494
>P04167:CP2B2_RAT Cytochrome P450 2B2 - Rattus norvegicus (Rat)| Length = 491 Score = 99.4 bits (246), Expect = 4e-20 Identities = 112/457 (24%), Positives = 195/457 (42%), Gaps = 40/457 (8%) Frame = +1 Query: 157 STGRLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDA 336 S G PPG LPL+G Q + + + Q ++YG VF L +PVV+ Sbjct: 26 SRGNFPPGPRPLPLLGNLLQLDRGG----LLNSFMQLREKYGDVFTVHLGPRPVVMLCGT 81 Query: 337 EVNRFIFQQEGKLFRSWYPDTANNIFGKESIASYDGSFHKYVRSFAS-------RLFGLD 495 + + A + G+ +IA + F +Y FA+ R F L Sbjct: 82 DT-----------IKEALVGQAEDFSGRGTIAVIEPIFKEYGVIFANGERWKALRRFSLA 130 Query: 496 SLRDV----------LLAEMDCNVTDSLAAWAA--EPAIEVKDAVANMVFDLTAKKLIGF 639 ++RD + E C V + + A +P + AN++ + + + Sbjct: 131 TMRDFGMGKRSVEERIQEEAQCLVEELRKSQGAPLDPTFLFQCITANIICSIVFGERFDY 190 Query: 640 SPEKSRKLRKNFDAFFQGLVSFPL-----------YFPGTTFYRCIQGRKNVQKVLKDL- 783 + + +L + F F L SF YFPG +R I KN+Q++L + Sbjct: 191 TDRQFLRLLELFYRTFSLLSSFSSQVFEFFSGFLKYFPGA--HRQIS--KNLQEILDYIG 246 Query: 784 ---LKERLGAPEKRHGDFLDEVVDELQSGRGVIDEKFAVD-LMAALL---FASFATVSSS 942 K R DF+D + ++ + +F + LM +LL FA T S++ Sbjct: 247 HIVEKHRATLDPSAPRDFIDTYLLRMEKEKSNHHTEFHHENLMISLLSLFFAGTETGSTT 306 Query: 943 LTIAMKFLSGHPNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSN 1122 L + +P+V E +++E + ++ G+ + ++ M +T V +EI R ++ Sbjct: 307 LRYGFLLMLKYPHVTEKVQKEIDQVI-----GSHRPPSLDDRTKMPYTDAVIHEIQRFAD 361 Query: 1123 VAP-GIFRKTLTDVQVKGYTIPAGWLVM-ISPMAVHLNPELFEDPLTFNPWRWQDESKKS 1296 +AP G+ + D +GY +P V I A+H +P+ F+ P TFNP + D Sbjct: 362 LAPIGLPHRVTKDTMFRGYLLPKNTEVYPILSSALH-DPQYFDHPDTFNPEHFLDADGTL 420 Query: 1297 TMLKNFMPFGGGIRLCVGAEFSRIQIALFLHTLVTKY 1407 + FMPF G R+C+G +R ++ LF T++ + Sbjct: 421 KKSEAFMPFSTGKRICLGEGIARNELFLFFTTILQNF 457
>Q05556:CP2AB_RABIT Cytochrome P450 2A11 - Oryctolagus cuniculus (Rabbit)| Length = 494 Score = 99.4 bits (246), Expect = 4e-20 Identities = 107/490 (21%), Positives = 199/490 (40%), Gaps = 46/490 (9%) Frame = +1 Query: 163 GRLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLK---RYGPVFKTSLVGQPVVVSMD 333 G+LPPG LP +G Q L+ Y +K RYGPVF L + +VV Sbjct: 31 GKLPPGPTPLPFIGNYLQ-------LNTEQMYDSLMKIRDRYGPVFTIHLGPRRIVVLCG 83 Query: 334 AEVNRFIFQQEGKLFRSWYPDTANNIFGKESIASYDGSFHKYVRSFAS-------RLFGL 492 E + D A + G+ A++D F Y +F++ R F + Sbjct: 84 QEA-----------VKEALVDQAEDFSGRGEQATFDWLFKGYGVAFSTWERARPLRRFAI 132 Query: 493 DSLRDVLLAEMDCN-------------VTDSLAAWAAEPAIEVKDAVANMV--------F 609 +LRD + + D+ A+ +P + V+N++ F Sbjct: 133 STLRDFGVGKRGIEERIQEEAGFLIEAFRDTRGAFI-DPTFFLSRTVSNVISSIVFGDRF 191 Query: 610 DLTAKK-------LIGFSPEKSRKLRKNFDAFFQGLVSFPLYFPGTTFYRCIQGRKN--V 762 D K+ ++G + + ++ F+ + P P ++ ++G ++ Sbjct: 192 DYEDKEFLSLLRMMLGSFQFTATPTGQLYEMFYSVMKHLP--GPQQQAFKELEGLRDFIA 249 Query: 763 QKVLKDLLKERLGAPEKRHGDFLDEVVDELQSGRGVIDEKFAVDLMAALLFASFATVSSS 942 +KV ++ +P FL + +E + + K V L FA TVS++ Sbjct: 250 KKVERNQRTLDPNSPRDFIDSFLIRMQEEKKDPKSEFHMKNLVLTTLNLFFAGTETVSTT 309 Query: 943 LTIAMKFLSGHPNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSN 1122 + L HP+V + EE + ++ + + +E+ M +T V +EI R ++ Sbjct: 310 MRYGFLLLMKHPDVEAKVHEEIDRVIGRNRQPK-----FEDRAKMPYTEAVIHEIQRFTD 364 Query: 1123 VAP-GIFRKTLTDVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKST 1299 + P G+ R+ D + + + +P G V +V +P+ F P F P + DE + Sbjct: 365 MIPMGLARRVTRDTKFRDFLLPKGTEVFPMLGSVLKDPKFFSKPREFYPQHFLDEKGQFK 424 Query: 1300 MLKNFMPFGGGIRLCVGAEFSRIQIALFLHTLVTKYRWKEIKGGE-----VQRISEIVFP 1464 FMPF G R C+G +R+++ LF T++ +R++ + + + + P Sbjct: 425 KSDAFMPFSVGKRYCLGEGLARMELFLFFTTIMQNFRFRSQQAPQDIDVSPKHVGFATIP 484 Query: 1465 EGYHIQIIPR 1494 Y + +PR Sbjct: 485 RTYTMSFVPR 494
>Q05555:CP2AA_RABIT Cytochrome P450 2A10 - Oryctolagus cuniculus (Rabbit)| Length = 494 Score = 99.4 bits (246), Expect = 4e-20 Identities = 107/490 (21%), Positives = 198/490 (40%), Gaps = 46/490 (9%) Frame = +1 Query: 163 GRLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLK---RYGPVFKTSLVGQPVVVSMD 333 G+LPPG LP +G Q L+ Y +K RYGPVF L + +VV Sbjct: 31 GKLPPGPTPLPFIGNYLQ-------LNTEQMYDSLMKISERYGPVFTIHLGPRRIVVLCG 83 Query: 334 AEVNRFIFQQEGKLFRSWYPDTANNIFGKESIASYDGSFHKYVRSFAS-------RLFGL 492 E + D A + G+ +A++D F Y F+S R F + Sbjct: 84 QEA-----------VKEALVDQAEDFSGRGELATFDWLFKGYGVVFSSWERARPLRRFAI 132 Query: 493 DSLRDVLLAEMDCN-------------VTDSLAAWAAEPAIEVKDAVANMV--------F 609 +LRD + + D+ A+ +P + V+N++ F Sbjct: 133 STLRDFGVGKRGIEERIQEEAGFLIEAFRDTRGAFI-DPTFFLSRTVSNVISSIVFGDRF 191 Query: 610 DLTAKK-------LIGFSPEKSRKLRKNFDAFFQGLVSFPLYFPGTTFYRCIQGRKN--V 762 D K+ ++G + + ++ F+ + P P ++ ++G ++ Sbjct: 192 DYEDKEFLSLLRMMLGSFQFTATPTGQLYEMFYSVMKHLP--GPQQQAFKELEGLRDFIA 249 Query: 763 QKVLKDLLKERLGAPEKRHGDFLDEVVDELQSGRGVIDEKFAVDLMAALLFASFATVSSS 942 +KV ++ +P FL + +E + + K V L FA TVS++ Sbjct: 250 KKVERNQRTLDPNSPRDFIDSFLIRMQEEKKDPKSEFHMKNLVMTTLNLFFAGTETVSTT 309 Query: 943 LTIAMKFLSGHPNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSN 1122 + L HP+V + EE + ++ + + +E+ M +T V +EI R ++ Sbjct: 310 MRYGFLLLMKHPDVEAKVHEEIDRVIGRNRQPK-----FEDRAKMPYTEAVIHEIQRFTD 364 Query: 1123 VAP-GIFRKTLTDVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKST 1299 + P G+ + D + + + +P G V +V +P+ F P F P + DE + Sbjct: 365 MIPMGLAHRVTRDTKFRDFLLPKGAEVFPMLGSVLKDPKFFSKPREFYPQHFLDEKGQFK 424 Query: 1300 MLKNFMPFGGGIRLCVGAEFSRIQIALFLHTLVTKYRWKEIKGGE-----VQRISEIVFP 1464 FMPF G R C+G +R+++ LF T++ +R++ + + + + P Sbjct: 425 KSDAFMPFSVGKRYCLGEGLARMELFLFFTTIMQNFRFRSQQAPQDIDVSPKHVGFATIP 484 Query: 1465 EGYHIQIIPR 1494 Y + +PR Sbjct: 485 RTYTMSFVPR 494
>O65438:C71AR_ARATH Cytochrome P450 71A27 - Arabidopsis thaliana (Mouse-ear cress)| Length = 499 Score = 99.4 bits (246), Expect = 4e-20 Identities = 112/452 (24%), Positives = 192/452 (42%), Gaps = 28/452 (6%) Frame = +1 Query: 166 RLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEVN 345 +LPP LP++G Q P+P + RYGP+ PV+V +V Sbjct: 32 KLPPSPWRLPVIGNLHQL-GPNPH----RYLHSLSLRYGPLMLLHFGRVPVLVVSCPDVT 86 Query: 346 RFIFQQEGKLFRSWYPDTANNIF---GKESIASYDGSFHKYVRSFA-------SRLFGLD 495 I + F + A NIF G++ I G K ++S + + Sbjct: 87 NDIMKTHDLKFANRPKSKAINIFMEGGRDIIFGPYGEDWKSMKSLGVVHLLNNKMVRSFE 146 Query: 496 SLRDVLLAEMDCNVTDSLAAWAAEPAIEVKDAVANMVFDLTAKKLIG--FSPEKSRKLRK 669 +LR+ + M + + A ++ ++ + + + D+ + +G ++ E+ K Sbjct: 147 NLREEEIKVMTEKLEE---ASSSSSSVNLSKLLMTLTNDIICRITLGRKYNEEEGGIDIK 203 Query: 670 NF---DAFFQGLVSFPLYFPGTTFYRCIQGRKNVQK--------VLKDLLKERLGAPEKR 816 N + F G F + P + I G + K L +++E + A K Sbjct: 204 NLVMTSSEFFGKFFFGDFIPSLAWIDWISGIDDKMKDINNKLDCFLDSMVQEHVDADHKE 263 Query: 817 HGDFLDEV--VDELQSGRGVIDEKFAVDLMAALLFASFATVSSSLTIAMKFLSGHPNVVE 990 DF+D + + + ++ R D + ++ + F+ AT +S L M L HP ++ Sbjct: 264 PSDFIDMLLLIQKDKTKRFKFDRSDLILILKDMFFSGTATTASQLEWTMTELMRHPECMK 323 Query: 991 SLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAPGIFRKTLTDVQVK 1170 L++E + +T +E + M + V E R+ P +FR DVQ+K Sbjct: 324 KLQDEINSFSTHN-----LNVTEKEVEKMNYLHCVIKEGLRLHPSGPLLFRLPSEDVQLK 378 Query: 1171 GYTIPAGWLVMISPMAVHLNPELFE-DPLTFNPWR--WQDESKKSTMLKNFMPFGGGIRL 1341 GY I AG V+I+ A+ NP ++ D + P R W + + T K F+PFG G RL Sbjct: 379 GYDISAGTHVIINAWALQRNPAIWGLDANEYRPERHFWYEFGFQRTDSK-FVPFGAGRRL 437 Query: 1342 CVGAEFSRIQIALFLHTLVTKYRWKEIKGGEV 1437 C G FS + L L LV ++ W+ +K G V Sbjct: 438 CPGIGFSLVLSKLALANLVKRFNWR-LKVGPV 468
>Q92088:CP2M1_ONCMY Cytochrome P450 2M1 - Oncorhynchus mykiss (Rainbow trout) (Salmo| gairdneri) Length = 499 Score = 99.0 bits (245), Expect = 6e-20 Identities = 109/454 (24%), Positives = 197/454 (43%), Gaps = 28/454 (6%) Frame = +1 Query: 157 STGRLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRL---KRYGPVFKTSLVGQPVVVS 327 S RLPPG +PL+G + +DV A YK + K+YG VF L +PVVV Sbjct: 32 SNSRLPPGPAPIPLLGNLLR-------MDVKAPYKLYMELSKKYGSVFTVWLGSKPVVVI 84 Query: 328 MDAEVNRFIFQQEGKLF--RSWYPDTANNIFGKESIASYDGSFHKYVRSFAS---RLFGL 492 + + F +G+ F R+ YP G + S G K +R F+ + FG+ Sbjct: 85 SGYQAIKDAFVTQGEEFSGRANYPVIMTVSKGYGVLVS-SGKRSKDLRRFSLMTLKTFGM 143 Query: 493 DSLRDVLLAEMDCNVTDSLAAWAAEPAIEVKDAVANMVFDLTAKKLIGFSPEKS----RK 660 + + + + + K+ + N V ++ + G E + Sbjct: 144 GRRSIEERVQEEAKMLVKAFGEYRDSVVNPKELLCNCVGNVICSIVFGHRFENDDPMFQL 203 Query: 661 LRKNFDAFFQGLVS--------FPLY---FPGT---TFYRCIQGRKNVQKVLKDLLKE-R 795 ++K DA+F L S FP FPG F + + +Q+ + LK Sbjct: 204 IQKAVDAYFNVLSSPIGAMYNMFPRIVWCFPGNHHEMFAIVNKAKVYIQEQAEIRLKTLN 263 Query: 796 LGAPEKRHGDFLDEVVDELQSGRGVIDEKFAVDLMAALLFASFATVSSSLTIAMKFLSGH 975 + P+ FL ++++E + V +L A T SS+L + + + Sbjct: 264 ISEPQDFIEAFLVKMLEEKDDPNTEFNNGNMVMTAWSLFAAGTETTSSTLRQSFLMMIKY 323 Query: 976 PNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAP-GIFRKTL 1152 P++ ES+++E + ++ R T ++ M +T V +E+ R +++P + K + Sbjct: 324 PHIQESVQKEIDEVIGSRVP------TVDDRVKMPYTDAVIHEVQRYMDLSPTSVPHKVM 377 Query: 1153 TDVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGG 1332 D + Y IP G +V+ +V ++P+LF++P F+P + DE+ F FG G Sbjct: 378 RDTEFYNYHIPEGTMVLPLLSSVLVDPKLFKNPDEFDPENFLDENGVFKKNDGFFAFGVG 437 Query: 1333 IRLCVGAEFSRIQIALFLHTLVTKYRWKEIKGGE 1434 R C G +R+++ LF +++ ++ + K E Sbjct: 438 KRACPGEALARVELFLFFTSVLQRFTFTGTKPPE 471
>P13108:CP2D4_RAT Cytochrome P450 2D4 - Rattus norvegicus (Rat)| Length = 500 Score = 99.0 bits (245), Expect = 6e-20 Identities = 114/461 (24%), Positives = 202/461 (43%), Gaps = 31/461 (6%) Frame = +1 Query: 118 LAHCVYKWTNPACSTGRLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKT 297 L H +WT+ R PPG + P++G Q ++PA +++ R+G +F Sbjct: 25 LMHRRQRWTS------RYPPGPVPWPVLGNLLQI----DFQNMPAGFQKLRCRFGDLFSL 74 Query: 298 SLVGQPVVV--SMDAEVNRFIFQQEGKLFRSWYPDTANNIFGKES----IASYDGSFHKY 459 L + VVV + A + E R + FG S +A Y ++ + Sbjct: 75 QLAFESVVVLNGLPALREALVKYSEDTADRPPLHFNDQSGFGPRSQGVVLARYGPAWRQQ 134 Query: 460 VRSFAS--RLFGLD--SLRDVLLAEMDCNVTDSL--AAWAAEPAIEVKDAVANMVFDLTA 621 R S R FGL SL + E C + + P + AV N++ L Sbjct: 135 RRFSVSTFRHFGLGKKSLEQWVTEEARCLCAAFADHSGFPFSPNTLLDKAVCNVIASLLF 194 Query: 622 KKLIGFSPEKSRKLR-------KNFDAFFQGLVS-FP--LYFPGTTFYRCIQGRKNVQKV 771 ++ + +L + F L++ FP L+ PG + G+K + Sbjct: 195 ACRFEYNDPRFIRLLDLLKDTLEEESGFLPMLLNVFPMLLHIPGL-LGKVFSGKKAFVAM 253 Query: 772 LKDLLKERLGA--PEKRHGDFLDEVVDELQSGRGVIDEKFAVD----LMAALLFASFATV 933 L +LL E P + D D + E++ +G + F + ++A L A T Sbjct: 254 LDELLTEHKVTWDPAQPPRDLTDAFLAEVEKAKGNPESSFNDENLRVVVADLFMAGMVTT 313 Query: 934 SSSLTIAMKFLSGHPNVVESLKEEHEAILK--KREEGAKSGITWEEYKSMTFTAQVTNEI 1107 S++LT A+ F+ HP+V +++E + ++ +R E A + M FT V +E+ Sbjct: 314 STTLTWALLFMILHPDVQCRVQQEIDEVIGQVRRPEMA-------DQARMPFTNAVIHEV 366 Query: 1108 SRVSNVAP-GIFRKTLTDVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDE 1284 R +++ P G+ KT D++V+G+ IP G ++ + +V + ++E PL F+P + D Sbjct: 367 QRFADILPLGVPHKTSRDIEVQGFLIPKGTTLITNLSSVLKDETVWEKPLRFHPEHFLDA 426 Query: 1285 SKKSTMLKNFMPFGGGIRLCVGAEFSRIQIALFLHTLVTKY 1407 + FMPF G R C+G +R+++ LF L+ ++ Sbjct: 427 QGNFVKHEAFMPFSAGRRACLGEPLARMELFLFFTCLLQRF 467
>Q27594:CP6A9_DROME Cytochrome P450 6a9 - Drosophila melanogaster (Fruit fly)| Length = 504 Score = 98.6 bits (244), Expect = 7e-20 Identities = 99/419 (23%), Positives = 183/419 (43%), Gaps = 33/419 (7%) Frame = +1 Query: 256 YKQRLKRYGPVFKTSLVGQPVVVSMDAEVNRFIFQQEGKLF--RSWYPDTANNIFGKESI 429 Y + + GP +P ++ +D + + I +E F R +Y +T ++ + + Sbjct: 62 YYNKFRGTGPFAGFYWFQRPGILVLDISLAKLILIKEFNKFTDRGFYHNTEDDPLSGQ-L 120 Query: 430 ASYDGSFHKYVRSFASRLFGLDSLRDVLLAEMDCN---VTDSLAAWAAEPAIEVKDAVAN 600 DG K +RS S F ++ + + + A P +EV+D +A Sbjct: 121 FLLDGQKWKSMRSKLSYTFTSGKMKYMFPTVVKVGHEFIEVFGQAMEKSPIVEVRDILAR 180 Query: 601 MVFDLTAKKLIGFSPEKSRKLRKNFDAFFQGLVSFPLYFP-GTTFYRCIQG---RKNVQK 768 D+ G + F + + + P G F Q R +++ Sbjct: 181 FTTDVIGTCAFGIECSSLKDPEAEFRVMGRRAIFEQRHGPIGIAFINSFQNLARRLHMKI 240 Query: 769 VLKD-------LLKERLGAPEK---RHGDFLDEVVD-------ELQSGRGVIDEKFAVDL 897 L++ +++E + EK R DF+D+++D + +SG V ++ Sbjct: 241 TLEEAEHFFLRIVRETVAFREKNNIRRNDFMDQLIDLKNSPLTKSESGESV---NLTIEE 297 Query: 898 MAALLF----ASFATVSSSLTIAMKFLSGHPNVVESLKEEHEAILKKREEGAKSGITWEE 1065 MAA F A F T S+++ A+ L+ H ++ + +++E + ++ K IT+E Sbjct: 298 MAAQAFVFFGAGFETSSTTMGFALYELAQHQDIQDRVRKECQEVIGKYN----GEITYES 353 Query: 1066 YKSMTFTAQVTNEISRVSNVAPGIFRKTLTDVQVKG---YTIPAGWLVMISPMAVHLNPE 1236 K M + QV +E R+ V P + R+ L D +V G Y I G V+I A+H + + Sbjct: 354 MKDMVYLDQVISETLRLYTVLPVLNRECLEDYEVPGHPKYVIKKGMPVLIPCGAMHRDEK 413 Query: 1237 LFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGIRLCVGAEFSRIQIALFLHTLVTKYRW 1413 L+ +P TFNP + E K ++PFG G R C+G F ++Q L L+ ++++ Sbjct: 414 LYANPNTFNPDNFSPERVKERDSVEWLPFGDGPRNCIGMRFGQMQARSGLALLINRFKF 472
>P08682:CP2E1_RABIT Cytochrome P450 2E1 - Oryctolagus cuniculus (Rabbit)| Length = 493 Score = 98.6 bits (244), Expect = 7e-20 Identities = 116/510 (22%), Positives = 214/510 (41%), Gaps = 39/510 (7%) Frame = +1 Query: 82 SLCGLAAVVAGWLAHCVY--KWTNPACSTGRLPPGSMGLPLVGETFQFFKPSPSLDVPAF 255 ++ G+ + GW+ ++ W S+ LPPG LP++G Q D+P Sbjct: 2 AVLGITVALLGWMVILLFISVWKQ-IHSSWNLPPGPFPLPIIGNLLQL----DLKDIPKS 56 Query: 256 YKQRLKRYGPVFKTSLVGQPVVVSMDAEVNRFIFQQEGKLFRSWYPDTANNIFGKESIAS 435 + + +R+GPVF L + VVV + R + F A F + I Sbjct: 57 FGRLAERFGPVFTVYLGSRRVVVLHGYKAVREMLLNHKNEFSGRGEIPAFREFKDKGIIF 116 Query: 436 YDGSFHKYVRSFASRLFGLDSLRDVLLAEMDCN---------VTDSLAAWAAEPAIEVKD 588 +G K +R F L +LRD + + + + L +P + Sbjct: 117 NNGPTWK-----DTRRFSLTTLRDYGMGKQGNEDRIQKEAHFLLEELRKTQGQP-FDPTF 170 Query: 589 AVANMVFDLTAKKLIG----FSPEKSRKLRKNFDAFFQGLVSFP---LYFPGTTFYRCIQ 747 + F++ AK L + +++ +L F+ F L+S P +Y + + + + Sbjct: 171 VIGCTPFNVIAKILFNDRFDYKDKQALRLMSLFNENFY-LLSTPWLQVYNNFSNYLQYMP 229 Query: 748 GRKNVQKVLKDL--LKERLGAPEKRH---------GDFLDEVVDELQSGRGVIDEKFAVD 894 G + +KV+K++ +KE A K H DF+D ++ E++ + + + ++ Sbjct: 230 G--SHRKVIKNVSEIKEYTLARVKEHHKSLDPSCPRDFIDSLLIEMEKDKHSTEPLYTLE 287 Query: 895 ----LMAALLFASFATVSSSLTIAMKFLSGHPNVVESLKEEHEAILKKREEGAKSGITWE 1062 +A + FA T S++L + L HP + E L EE + ++ G + Sbjct: 288 NIAVTVADMFFAGTETTSTTLRYGLLILLKHPEIEEKLHEEIDRVI-----GPSRMPSVR 342 Query: 1063 EYKSMTFTAQVTNEISRVSNVAP-GIFRKTLTDVQVKGYTIPAGWLVMISPMAVHLNPEL 1239 + M + V +EI R ++ P + + D +GY IP G +V+ + ++ + + Sbjct: 343 DRVQMPYMDAVVHEIQRFIDLVPSNLPHEATRDTTFQGYVIPKGTVVIPTLDSLLYDKQE 402 Query: 1240 FEDPLTFNPWRWQDESKKSTMLKNFMPFGGGIRLCVGAEFSRIQIALFLHTLVTKYRWKE 1419 F DP F P + +E K F PF G R+CVG +R+++ L L ++ + K Sbjct: 403 FPDPEKFKPEHFLNEEGKFKYSDYFKPFSAGKRVCVGEGLARMELFLLLSAILQHFNLKP 462 Query: 1420 IKGGEVQRISEIV-----FPEGYHIQIIPR 1494 + E + I P Y + +IPR Sbjct: 463 LVDPEDIDLRNITVGFGRVPPRYKLCVIPR 492
>Q64680:CP2DI_RAT Cytochrome P450 2D18 - Rattus norvegicus (Rat)| Length = 500 Score = 98.6 bits (244), Expect = 7e-20 Identities = 121/495 (24%), Positives = 215/495 (43%), Gaps = 36/495 (7%) Frame = +1 Query: 118 LAHCVYKWTNPACSTGRLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKT 297 L H +WT+ R PPG + P++G Q ++PA +++ R+G +F Sbjct: 25 LMHRRQRWTS------RYPPGPVPWPVLGNLLQI----DFQNMPAGFQKLRCRFGDLFSL 74 Query: 298 SLVGQPVVV--SMDAEVNRFIFQQEGKLFRSWYPDTANNIFGKES----IASYDGSFHKY 459 L + VVV + A + E R + FG S +A Y ++ + Sbjct: 75 QLAFESVVVLNGLPALREALVKYSEDTADRPPLHFNDQSGFGPRSQGVVLARYGPAWRQQ 134 Query: 460 VRSFAS--RLFGLD--SLRDVLLAEMDCNVTDSL--AAWAAEPAIEVKDAVANMVFDLTA 621 R S R FGL SL + E C + + P + AV N++ L Sbjct: 135 RRFSVSTFRHFGLGKKSLEQWVTEEARCLCAAFADHSGFPFSPNTLLDKAVCNVIASLLF 194 Query: 622 KKLIGFSPEKSRKLR-------KNFDAFFQGLVS-FP--LYFPGTTFYRCIQGRKNVQKV 771 ++ + +L + F L++ FP L+ PG + G+K + Sbjct: 195 ACRFEYNDPRFIRLLDLLKDTLEEESGFLPMLLNVFPMLLHIPGL-LGKVFSGKKAFVAM 253 Query: 772 LKDLLKERLGA--PEKRHGDFLDEVVDELQSGRGVIDEKFAVD----LMAALLFASFATV 933 L +LL E P + D D + E++ +G + F + ++A L A T Sbjct: 254 LDELLTEHKVTWDPAQPPRDLTDAFLAEVEKAKGNPESSFNDENLRVVVADLFMAGMVTT 313 Query: 934 SSSLTIAMKFLSGHPNVVESLKEEHEAILK--KREEGAKSGITWEEYKSMTFTAQVTNEI 1107 S++LT A+ F+ P+V +++E + ++ +R E A + M FT V +E+ Sbjct: 314 STTLTWALLFMILRPDVQCRVQQEIDEVIGQVRRPEMA-------DQARMPFTNAVIHEV 366 Query: 1108 SRVSNVAP-GIFRKTLTDVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDE 1284 R +++ P G+ KT D++V+G+ IP G ++I+ +V + ++E PL F+P + D Sbjct: 367 QRFADILPLGVPHKTSRDIEVQGFLIPKGTTLIINLSSVLKDETVWEKPLRFHPEHFLDA 426 Query: 1285 SKKSTMLKNFMPFGGGIRLCVGAEFSRIQIALFLHTLVTKYRWKEIKGGEVQRISEIVF- 1461 + FMPF G R C+G +R+++ LF L+ ++ + + G+ + + VF Sbjct: 427 QGNFVKHEAFMPFSAGRRACLGEPLARMELFLFFTCLLQRFSF-SVPAGQPRPSNYGVFG 485 Query: 1462 ----PEGYHIQIIPR 1494 P Y + PR Sbjct: 486 ALTTPRPYQLCASPR 500
>P24456:CP2DA_MOUSE Cytochrome P450 2D10 - Mus musculus (Mouse)| Length = 504 Score = 98.6 bits (244), Expect = 7e-20 Identities = 116/489 (23%), Positives = 215/489 (43%), Gaps = 40/489 (8%) Frame = +1 Query: 118 LAHCVYKWTNPACSTGRLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLK-RYGPVFK 294 L H +WT+ R PPG + P++G Q LD + +L+ RYG VF Sbjct: 25 LMHRHQRWTS------RYPPGPVPWPVLGNLLQV-----DLDNMPYSLYKLQNRYGDVFS 73 Query: 295 TSLVGQPVVVSMDAEVNRFIFQQEGKLFRSWYPDTANN----IF-------GKESI--AS 435 + +P+VV + + + G+ DTA+ IF G + + A Sbjct: 74 LQMGWKPMVVINGLKAMKEVLLTCGE-------DTADRPQVPIFEYLGVKPGSQGVVLAP 126 Query: 436 YDGSFHKYVRSFASRL--FGLD--SLRDVLLAEMD--CNVTDSLAAWAAEPAIEVKDAVA 597 Y + + R S L FGL SL D + E C+ + A P + +AV Sbjct: 127 YGPEWREQRRFSVSTLRNFGLGKKSLEDWVTKEARHLCDAFTAQAGQPINPNTMLNNAVC 186 Query: 598 NMVFDLTAKKLIGFSPEKSRKLRKNFD---AFFQGLVS-----FPLYF-----PGTTFYR 738 N++ L + + +++K + GL+ FP+ PG F Sbjct: 187 NVIASLIFARRFEYEDPYLIRMQKVLEDSLTEISGLIPEVLNMFPILLRIPGLPGKVF-- 244 Query: 739 CIQGRKNVQKVLKDLLKERLGA--PEKRHGDFLDEVVDELQSGRGVIDEKFAVD----LM 900 QG+K++ ++++LL E P++ + D + E++ +G + F + ++ Sbjct: 245 --QGQKSLLAIVENLLTENRNTWDPDQPPRNLTDAFLAEIEKVKGNAESSFNDENLRMVV 302 Query: 901 AALLFASFATVSSSLTIAMKFLSGHPNVVESLKEEHEAILKKREEGAKSGITWEEYKSMT 1080 L A T S++L+ A+ + HP+V +++E +A++ G + M Sbjct: 303 LDLFTAGMVTTSTTLSWALLLMILHPDVQRRVQQEIDAVI-----GQVRHPEMADQARMP 357 Query: 1081 FTAQVTNEISRVSNVAP-GIFRKTLTDVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLT 1257 +T V +E+ R ++AP + R T D++V+ + IP G +++ + +V + ++E PL Sbjct: 358 YTNAVIHEVQRFGDIAPLNLPRITSRDIEVQDFLIPKGSILIPNMSSVLKDETVWEKPLR 417 Query: 1258 FNPWRWQDESKKSTMLKNFMPFGGGIRLCVGAEFSRIQIALFLHTLVTKYRWKEIKGGEV 1437 F+P + D + FMPF G R C+G +R+++ LF L+ + + + G+ Sbjct: 418 FHPEHFLDAQGHFVKPEAFMPFSAGRRSCLGEPLARMELFLFFTCLLQHFSF-SVPNGQP 476 Query: 1438 QRISEIVFP 1464 + + VFP Sbjct: 477 RPRNLGVFP 485
>P10614:CP51_YEAST Cytochrome P450 51 - Saccharomyces cerevisiae (Baker's yeast)| Length = 530 Score = 98.2 bits (243), Expect = 1e-19 Identities = 99/442 (22%), Positives = 178/442 (40%), Gaps = 47/442 (10%) Frame = +1 Query: 253 FYKQRLKRYGPVFKTSLVGQPVVVSMDAEVNRFIFQQE--GKLFRSWYPDTANNIFGKES 426 F+++ K+YG +F L+G+ + V + + + F+F + + Y +FGK Sbjct: 79 FFEECQKKYGDIFSFVLLGRVMTVYLGPKGHEFVFNAKLADVSAEAAYAHLTTPVFGKGV 138 Query: 427 IASYDGS-----------------FHKYVRSFASRLFGLDSLRDVLLAEMDCNVTDSLAA 555 I S F YV A ++ RD ++ T ++ Sbjct: 139 IYDCPNSRLMEQKKFVKGALTKEAFKSYVPLIAEEVYKY--FRDSKNFRLNERTTGTIDV 196 Query: 556 WAAEPAIEVKDAVANMVFDLTAKKLIGFSPEKSRKLRKNFDAFF----QGLVSFPLYFPG 723 +P + + A ++ L+G E KL +F + +G FP Sbjct: 197 MVTQPEMTIFTA---------SRSLLG--KEMRAKLDTDFAYLYSDLDKGFTPINFVFPN 245 Query: 724 TTFYRCIQGRKNVQKVLK----DLLKERLGAPEKRHGDFLDEVVDE--LQSGRGVIDEKF 885 + R + QK + L+KER + + D +D ++ + G + D++ Sbjct: 246 LPLEH-YRKRDHAQKAISGTYMSLIKERRKNNDIQDRDLIDSLMKNSTYKDGVKMTDQEI 304 Query: 886 AVDLMAALLFASFATVSSSLTIAMKFLSGHPNVVESLKEEHEAILKKREEGAKSGITWEE 1065 A L+ L+ + ++S I + L+ P+V + L EE +L +G K +T++ Sbjct: 305 ANLLIGVLMGGQHTSAATSAWILLH-LAERPDVQQELYEEQMRVL----DGGKKELTYDL 359 Query: 1066 YKSMTFTAQVTNEISRVSNVAPGIFRKTLTDVQVKG--YTIPAGWLVMISPMAVHLNPEL 1239 + M Q E R+ + +FRK + D+ V Y IPAG+ V++SP HL E Sbjct: 360 LQEMPLLNQTIKETLRMHHPLHSLFRKVMKDMHVPNTSYVIPAGYHVLVSPGYTHLRDEY 419 Query: 1240 FEDPLTFNPWRWQDESKKSTML----------------KNFMPFGGGIRLCVGAEFSRIQ 1371 F + FN RW +S S + ++PFGGG C+G F+ Q Sbjct: 420 FPNAHQFNIHRWNKDSASSYSVGEEVDYGFGAISKGVSSPYLPFGGGRHRCIGEHFAYCQ 479 Query: 1372 IALFLHTLVTKYRWKEIKGGEV 1437 + + + + +W +G V Sbjct: 480 LGVLMSIFIRTLKWHYPEGKTV 501
>O35293:CP2F2_RAT Cytochrome P450 2F2 - Rattus norvegicus (Rat)| Length = 491 Score = 98.2 bits (243), Expect = 1e-19 Identities = 105/442 (23%), Positives = 186/442 (42%), Gaps = 27/442 (6%) Frame = +1 Query: 163 GRLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEV 342 G+LPPG LP++G Q S D+ + K YG VF L + V+V + Sbjct: 28 GQLPPGPKPLPILGNLLQL----RSQDLLTSLTKLSKDYGSVFTVYLGPRRVIVLSGYQT 83 Query: 343 NRFIFQQEGKLF--RSWYPDTANNIFGKESIASYDGSFHKYVRSFASRLF-----GLDSL 501 + +G+ F R YP N G IA DG K +R F+ ++ G S+ Sbjct: 84 VKEALVDKGEEFSGRGSYPIFFNFTKGN-GIAFSDGERWKILRRFSVQILRNFGMGKRSI 142 Query: 502 RDVLLAEMD--CNVTDSLAAWAAEPAIEVKDAVANMVFDLTAKKLIGFSPEKSRKLRKNF 675 + +L E +V +P + +V+N++ + + E+ + Sbjct: 143 EERILEEGSFLLDVLRKTEGKPFDPVFILSRSVSNIICSVIFGSRFDYDDERLLTIIHFI 202 Query: 676 DAFFQGLVS--------FPLYF-----PGTTFYRCIQGRKNVQKVLKDLLKERLGAPEKR 816 + FQ + S FP P +R G K++ + + + + + Sbjct: 203 NDNFQIMSSPWGEMYNIFPSLLDWVPGPHRRVFRNFGGMKDL--IARSVREHQDSLDPNS 260 Query: 817 HGDFLD----EVVDELQSGRGVIDEKFAVDLMAALLFASFATVSSSLTIAMKFLSGHPNV 984 DF+D ++V E Q + + LLF TV ++L A L +P V Sbjct: 261 PRDFIDCFLTKMVQEKQDPLSHFNMDTLLMTTHNLLFGGTETVGTTLRHAFLILMKYPKV 320 Query: 985 VESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAP-GIFRKTLTDV 1161 ++EE + ++ G T E+ SM +T V +E+ R ++V P + + + D Sbjct: 321 QARVQEEIDCVV-----GRSRMPTLEDRASMPYTDAVIHEVQRFADVIPMNLPHRVIRDT 375 Query: 1162 QVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGIRL 1341 +G+ IP G V+ VH + + F+ P FNP + D ++ FMPF G RL Sbjct: 376 PFRGFLIPKGTDVITLLNTVHYDSDQFKTPQEFNPEHFLDANQSFKKSPAFMPFSAGRRL 435 Query: 1342 CVGAEFSRIQIALFLHTLVTKY 1407 C+G +R+++ ++L +++ + Sbjct: 436 CLGEPLARMELFIYLTSILQNF 457
>P24462:CP3A7_HUMAN Cytochrome P450 3A7 - Homo sapiens (Human)| Length = 503 Score = 97.8 bits (242), Expect = 1e-19 Identities = 106/448 (23%), Positives = 194/448 (43%), Gaps = 27/448 (6%) Frame = +1 Query: 175 PGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEVNRFI 354 PG LP +G F K + D+ + K+Y V+ QP++ D ++ + + Sbjct: 39 PGPTPLPFLGNALSFRKGYWTFDMECY-----KKYRKVWGIYDCQQPMLAITDPDMIKTV 93 Query: 355 FQQEG-KLFRSWYPDTANNIFGKESIASYDGSFHKYVRSFASRLFGLDSLRDV--LLAEM 525 +E +F + P F K +I+ + K +RS S F L+++ ++A+ Sbjct: 94 LVKECYSVFTNRRPFGPVG-FMKNAISIAEDEEWKRIRSLLSPTFTSGKLKEMVPIIAQY 152 Query: 526 DCNVTDSLAAWAAE-PAIEVKDAVANMVFDLTAKKLIGFS-----------PEKSRKLRK 669 + +L A + +K D+ G S E ++KL + Sbjct: 153 GDVLVRNLRREAETGKPVTLKHVFGAYSMDVITSTSFGVSIDSLNNPQDPFVENTKKLLR 212 Query: 670 --NFDAFFQGLVSFPLYFPG------TTFYRCIQGRKNVQKVLKDLLKERLGAPEKRHGD 825 D F + FP P T F R + + K +K + + RL +K D Sbjct: 213 FNPLDPFVLSIKVFPFLTPILEALNITVFPRKVISF--LTKSVKQIKEGRLKETQKHRVD 270 Query: 826 FLDEVVDELQSGRGVIDEKFA-VDLMAA---LLFASFATVSSSLTIAMKFLSGHPNVVES 993 FL ++D S + + ++LMA +FA + T SS L+ + L+ HP+V + Sbjct: 271 FLQLMIDSQNSKDSETHKALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQK 330 Query: 994 LKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAPGIFRKTLTDVQVKG 1173 +++E + +L K+ T++ + + V NE R+ VA + R DV++ G Sbjct: 331 VQKEIDTVLPN-----KAPPTYDTVLQLEYLDMVVNETLRLFPVAMRLERVCKKDVEING 385 Query: 1174 YTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGIRLCVGA 1353 IP G +VMI +H +P+ + +P F P R+ ++K + + PFG G R C+G Sbjct: 386 MFIPKGVVVMIPSYVLHHDPKYWREPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGM 445 Query: 1354 EFSRIQIALFLHTLVTKYRWKEIKGGEV 1437 F+ + + L L ++ + +K K ++ Sbjct: 446 RFALVNMKLALVRVLQNFSFKPCKETQI 473
>P00179:CP2C5_RABIT Cytochrome P450 2C5 - Oryctolagus cuniculus (Rabbit)| Length = 487 Score = 97.8 bits (242), Expect = 1e-19 Identities = 112/471 (23%), Positives = 200/471 (42%), Gaps = 28/471 (5%) Frame = +1 Query: 163 GRLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEV 342 G+LPPG P++G Q S + F + YGPVF L +P VV E Sbjct: 27 GKLPPGPTPFPIIGNILQIDAKDISKSLTKFSEC----YGPVFTVYLGMKPTVVLHGYEA 82 Query: 343 NRFIFQQEGKLF--RSWYPDTANNIFGKESIASYDGSFHKYVRSFAS---RLFGLD--SL 501 + G+ F R P + IA + K +R F+ R FG+ S+ Sbjct: 83 VKEALVDLGEEFAGRGSVP-ILEKVSKGLGIAFSNAKTWKEMRRFSLMTLRNFGMGKRSI 141 Query: 502 RDVLLAEMDCNVTD--SLAAWAAEPAIEVKDAVANMVFDLTAKKLIGFSPEKSRKLRKNF 675 D + E C V + A +P + A N++ + + E+ KL ++ Sbjct: 142 EDRIQEEARCLVEELRKTNASPCDPTFILGCAPCNVICSVIFHNRFDYKDEEFLKLMESL 201 Query: 676 DA--------FFQGLVSFPL---YFPGTTFYRCIQGRKNVQKVLKDLLKERLGAPEKRHG 822 + + Q +FP YFPG ++ ++ + + +KE + + Sbjct: 202 NENVRILSSPWLQVYNNFPALLDYFPGI-HKTLLKNADYIKNFIMEKVKEHQKLLDVNNP 260 Query: 823 -DFLDEVVDELQSGRGVIDEKFAVDLMAALLF-ASFATVSSSLTIAMKFLSGHPNVVESL 996 DF+D + +++ + ++ + + LF A T S++L ++ L HP V + Sbjct: 261 RDFIDCFLIKMEQENNLEFTLESLVIAVSDLFGAGTETTSTTLRYSLLLLLKHPEVAARV 320 Query: 997 KEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAPGIFRKTLT-DVQVKG 1173 +EE E ++ G ++ M +T V +EI R ++ P +T DV+ + Sbjct: 321 QEEIERVI-----GRHRSPCMQDRSRMPYTDAVIHEIQRFIDLLPTNLPHAVTRDVRFRN 375 Query: 1174 YTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGIRLCVGA 1353 Y IP G ++ S +V + + F +P F+P + DES FMPF G R+CVG Sbjct: 376 YFIPKGTDIITSLTSVLHDEKAFPNPKVFDPGHFLDESGNFKKSDYFMPFSAGKRMCVGE 435 Query: 1354 EFSRIQIALFLHTLVTKYRWKEIKGGEVQRISEIV-----FPEGYHIQIIP 1491 +R+++ LFL +++ ++ + + + I+ +V P Y + IP Sbjct: 436 GLARMELFLFLTSILQNFKLQSLVEPKDLDITAVVNGFVSVPPSYQLCFIP 486
>P33270:CP6A2_DROME Cytochrome P450 6a2 - Drosophila melanogaster (Fruit fly)| Length = 506 Score = 97.4 bits (241), Expect = 2e-19 Identities = 78/318 (24%), Positives = 148/318 (46%), Gaps = 26/318 (8%) Frame = +1 Query: 535 VTDSLAAWAAEPAIEVKDAVANMVFDLTAKKLIGFSPEKSRKLRKNFDAFFQG------- 693 +T+ + A +E+K+ +A D+ G R +F Q Sbjct: 160 ITEQVPAAQNGAVLEIKELMARFTTDVIGTCAFGIECNTLRTPVSDFRTMGQKVFTDMRH 219 Query: 694 ---LVSFPLYFPG-TTFYRCIQGRKNVQKVLKDLLKERLGAPEK---RHGDFLDEVVDEL 852 L F FP + R ++V + L+ + + E+ + DF++ +++ Sbjct: 220 GKLLTMFVFSFPKLASRLRMRMMPEDVHQFFMRLVNDTIALRERENFKRNDFMNLLIELK 279 Query: 853 QSGRGVID-----EKFAVDLMAALLF----ASFATVSSSLTIAMKFLSGHPNVVESLKEE 1005 Q GR +D E + +AA +F A F T SS+++ + L+ + ++ + L+ E Sbjct: 280 QKGRVTLDNGEVIEGMDIGELAAQVFVFYVAGFETSSSTMSYCLYELAQNQDIQDRLRNE 339 Query: 1006 HEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAPGIFRKTLTDVQVKGY--- 1176 + +L+++E +T+E K+MT+ QV +E R+ + P + RK L D V G+ Sbjct: 340 IQTVLEEQE----GQLTYESIKAMTYLNQVISETLRLYTLVPHLERKALNDYVVPGHEKL 395 Query: 1177 TIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGIRLCVGAE 1356 I G V+I A H + +L+ +P TF+P R+ E + ++PFG G R C+G Sbjct: 396 VIEKGTQVIIPACAYHRDEDLYPNPETFDPERFSPEKVAARESVEWLPFGDGPRNCIGMR 455 Query: 1357 FSRIQIALFLHTLVTKYR 1410 F ++Q + L +++++R Sbjct: 456 FGQMQARIGLAQIISRFR 473
>P51589:CP2J2_HUMAN Cytochrome P450 2J2 - Homo sapiens (Human)| Length = 502 Score = 97.4 bits (241), Expect = 2e-19 Identities = 103/470 (21%), Positives = 204/470 (43%), Gaps = 29/470 (6%) Frame = +1 Query: 172 PPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSL--VGQPVVVSMDAEVN 345 PPG LP +G F L+V F +K+YG +F L + ++ + Sbjct: 44 PPGPWRLPFLGNFFLVDFEQSHLEVQLF----VKKYGNLFSLELGDISAVLITGLPLIKE 99 Query: 346 RFIFQQEGKLFRSWYPDTANNIFGKESIASYDGSFHKYVRSF---ASRLFGLD--SLRDV 510 I + R P +IF K + G K R F A R FGL SL + Sbjct: 100 ALIHMDQNFGNRPVTP-MREHIFKKNGLIMSSGQAWKEQRRFTLTALRNFGLGKKSLEER 158 Query: 511 LLAEMDCNVTDSLA---AWAAEPAIEVKDAVANMVFDLTAKKLIGFSPEKSRKLRKNFD- 678 + E ++T+++ +P ++ +AV+N++ +T + + ++L K D Sbjct: 159 IQEEAQ-HLTEAIKEENGQPFDPHFKINNAVSNIICSITFGERFEYQDSWFQQLLKLLDE 217 Query: 679 -AFFQGLVSFPLYFPGTTFYRCIQGRKNVQ----KVLKDLLKERLGAPEKRHG-----DF 828 + + + LY + + G K LK + + K DF Sbjct: 218 VTYLEASKTCQLYNVFPWIMKFLPGPHQTLFSNWKKLKLFVSHMIDKHRKDWNPAETRDF 277 Query: 829 LDEVVDELQSGRGVIDEKFAVDLMAA----LLFASFATVSSSLTIAMKFLSGHPNVVESL 996 +D + E+ G F + + L FA T S++L A+ +++ +P + E + Sbjct: 278 IDAYLKEMSKHTGNPTSSFHEENLICSTLDLFFAGTETTSTTLRWALLYMALYPEIQEKV 337 Query: 997 KEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAP-GIFRKTLTDVQVKG 1173 + E + ++ + ++ + + +SM +T V +E+ R+ N+ P + R+ D + G Sbjct: 338 QAEIDRVIGQGQQPSTAA-----RESMPYTNAVIHEVQRMGNIIPLNVPREVTVDTTLAG 392 Query: 1174 YTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGIRLCVGA 1353 Y +P G +++ + A+H +P + P TFNP + E+ + + FMPF G R C+G Sbjct: 393 YHLPKGTMILTNLTALHRDPTEWATPDTFNPDHFL-ENGQFKKREAFMPFSIGKRACLGE 451 Query: 1354 EFSRIQIALFLHTLVTKYRWKEIKGGEVQ---RISEIVFPEGYHIQIIPR 1494 + +R ++ +F +L+ K+ ++ ++ R+ + P + + +P+ Sbjct: 452 QLARTELFIFFTSLMQKFTFRPPNNEKLSLKFRMGITISPVSHRLCAVPQ 501
>P20678:CP2H2_CHICK Cytochrome P450 2H2 - Gallus gallus (Chicken)| Length = 491 Score = 97.4 bits (241), Expect = 2e-19 Identities = 112/487 (22%), Positives = 202/487 (41%), Gaps = 43/487 (8%) Frame = +1 Query: 163 GRLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEV 342 G+ PPG +P++G FQ D+ +K+ K+YGP+F L + VVV +V Sbjct: 30 GKEPPGPTPIPIIGNVFQL----NPWDLMESFKELSKKYGPIFTIHLGPKKVVVLYGYDV 85 Query: 343 NRFIFQQEGKLF--RSWYPDTANNIFGKESIASYDGSFHKYVRSFASRLFGLDSLRDVLL 516 + G+ F R P +F I + +G + +R FA L +LRD + Sbjct: 86 VKEALIDNGEAFSGRGNLP-LFEKVFKGTGIVTSNGESWRQMRRFA-----LTTLRDFGM 139 Query: 517 AEMDCNVT-DSLAAWAAE-----------PAIEVKDAVANMV--------FDLTAKK--- 627 + A + E P + + AV+N++ FD KK Sbjct: 140 GKKSIEERIQEEARFLVERIRNTHEKPFNPTVFLMHAVSNIICSTVFGDRFDYEDKKFLD 199 Query: 628 LIGFSPEKSR---KLRKNFDAFFQGLVSFPLYFPGTTFYRCIQGRKNVQKVLKDLLKERL 798 LI E R +++ FF ++ + L P T + I+ + D + E + Sbjct: 200 LIEMLDENERYQNRIQTQLYNFFPTILDY-LPGPHKTLIKSIE-------TVDDFITEII 251 Query: 799 GAPEKRHG-----DFLDEVVDELQSGRGVIDEKFAVDLMAA----LLFASFATVSSSLTI 951 A ++ DF+D ++++Q + + F V+ + L A T S++L Sbjct: 252 RAHQESFDASCPRDFIDAFINKMQQEKE--NSYFTVESLTRTTLDLFLAGTGTTSTTLRY 309 Query: 952 AMKFLSGHPNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAP 1131 + L HP + E + +E + ++ G + + +T V +EI R + P Sbjct: 310 GLLILLKHPEIEEKMHKEIDRVV-----GRDRSPCMADRSQLPYTDAVIHEIQRFIDFLP 364 Query: 1132 -GIFRKTLTDVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLK 1308 + R + D +++ Y IP ++ + + + F +P F+P + + + Sbjct: 365 VNLPRAVIKDTKLRDYFIPKDTMIFPLLSPILQDCKEFPNPEKFDPGHFLNANGTFRKSN 424 Query: 1309 NFMPFGGGIRLCVGAEFSRIQIALFLHTLVTKYRWKEIKGGEVQRISEIV-----FPEGY 1473 FMPF G R+C G +R+++ LFL +++ + K +K + IS IV P Y Sbjct: 425 YFMPFSAGKRICAGEGLARMELFLFLTSILQNFSLKPVKDRKDIDISPIVTSAANIPRPY 484 Query: 1474 HIQIIPR 1494 + IPR Sbjct: 485 EVSFIPR 491
>P10634:CP2DQ_RAT Cytochrome P450 2D26 - Rattus norvegicus (Rat)| Length = 500 Score = 97.4 bits (241), Expect = 2e-19 Identities = 115/456 (25%), Positives = 196/456 (42%), Gaps = 33/456 (7%) Frame = +1 Query: 160 TGRLPPGSMGLPLVGETFQF-FKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVV--SM 330 T PPG + LP +G Q F+ P + YK R RYG VF + +PVVV + Sbjct: 33 TAHYPPGPVPLPGLGNLLQVDFENMPY----SLYKLR-SRYGDVFSLQIAWKPVVVINGL 87 Query: 331 DAEVNRFIFQQEGKLFRSWYPDTANNIFGKES----IASYDGSFHKYVRSFASRL----F 486 A + E R P + +G +S +A Y + + R S L Sbjct: 88 KAVRELLVTYGEDTADRPLLPIYNHLGYGNKSKGVVLAPYGPEWREQRRFSVSTLRDFGV 147 Query: 487 GLDSLRDVLLAEMD--CNVTDSLAAWAAEPAIEVKDAVANMVFDLT-AKKLIGFSPEKSR 657 G SL + E C+ A P+I + AV+N++ L A++ P +R Sbjct: 148 GKKSLEQWVTEEAGHLCDTFAKEAEHPFNPSILLSKAVSNVIASLVYARRFEYEDPFFNR 207 Query: 658 KLRKNFDAFFQG-------LVSFPLYF-----PGTTFYRCIQGRKNVQKVLKDLLKERLG 801 L+ ++F + L + P+ PG F + V K+L + K Sbjct: 208 MLKTLKESFGEDTGFMAEVLNAIPILLQIPGLPGKVFPKLNSFIALVDKMLIEHKKSWDP 267 Query: 802 APEKRHGDFLDEVVDELQSGRGVIDEKFAVD----LMAALLFASFATVSSSLTIAMKFLS 969 A R D D + E+Q +G + F + ++ L A T S++L+ A+ + Sbjct: 268 AQPPR--DMTDAFLAEMQKAKGNPESSFNDENLRLVVIDLFMAGMVTTSTTLSWALLLMI 325 Query: 970 GHPNVVESLKEEHEAILK--KREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAP-GIF 1140 HP+V + EE + ++ +R E A + M FT V +E+ R +++ P I Sbjct: 326 LHPDVQRRVHEEIDEVIGQVRRPEMA-------DQARMPFTNAVIHEVQRFADIVPTNIP 378 Query: 1141 RKTLTDVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMP 1320 T D++ +G+ IP G ++ + +V + ++E PL F+P + D + FMP Sbjct: 379 HMTSRDIKFQGFLIPKGTTLIPNLSSVLKDETVWEKPLRFHPEHFLDAQGNFVKHEAFMP 438 Query: 1321 FGGGIRLCVGAEFSRIQIALFLHTLVTKYRWKEIKG 1428 F G R C+G +R+++ LF L+ ++ + + G Sbjct: 439 FSAGRRACLGEPLARMELFLFFTCLLQRFSFSVLAG 474
>P56657:CP240_MOUSE Cytochrome P450 2C40 - Mus musculus (Mouse)| Length = 491 Score = 97.4 bits (241), Expect = 2e-19 Identities = 105/451 (23%), Positives = 188/451 (41%), Gaps = 31/451 (6%) Frame = +1 Query: 163 GRLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEV 342 G LPPG LP++G + D+ K YGPVF QP+VV E Sbjct: 27 GNLPPGPTPLPIIGN----YHLIDMKDIGQCLTNFSKTYGPVFTLYFGSQPIVVLHGYEA 82 Query: 343 NRFIFQQEGKLF--RSWYPDTANNIFGKESIASYDGSFHKYVRSFASRLFGLDSLRDVLL 516 + G+ F R P +F K S G H V A+R+F +++LR++ + Sbjct: 83 IKEALIDHGEEFSGRGRIP-----VFDKVSTGKGIGFSHGNVWK-ATRVFTVNTLRNLGM 136 Query: 517 AEMDC-NVTDSLAAWA-----------AEPAIEVKDAVANMV--------FDLTAK---K 627 + N A W +P + A N++ FD K Sbjct: 137 GKRTIENKVQEEAQWLMKELKKTNGSPCDPQFIIGCAPCNVICSIVFQNRFDYKDKDFLS 196 Query: 628 LIGFSPEKSRKLRKNFDAFFQGLVSFPLYFPGTTFYRCIQGRKNVQKVLKDLLKERLGAP 807 LIG E + L F + Y PG+ + + ++ L +KE + Sbjct: 197 LIGKVNECTEILSSPGCQIFNAVPILIDYCPGS-HNKLFKNHTWIKSYLLGKIKEHEESL 255 Query: 808 EKRHG-DFLDEVVDELQSGRGVIDEKFAVDLMAALL----FASFATVSSSLTIAMKFLSG 972 + + DF+D + + + G+ + ++ +A L+ F T+SS++ A+ L Sbjct: 256 DVTNPRDFIDYFLIQRRQKNGIEHMDYTIEHLATLVTDLVFGGTETLSSTMRFALLLLMK 315 Query: 973 HPNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAP-GIFRKT 1149 H ++ ++EE + ++ G ++ M +T + +E+ R ++ P G+ + Sbjct: 316 HTHITAKVQEEIDNVI-----GRHRSPCMQDRNHMPYTNAMVHEVQRYIDLGPNGVVHEV 370 Query: 1150 LTDVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGG 1329 D + + Y I G VM S +V + F +P F+P + D++ F+PF Sbjct: 371 TCDTKFRNYFILKGTQVMTSLTSVLHDSTEFPNPEVFDPGHFLDDNGNFKKSDYFVPFSA 430 Query: 1330 GIRLCVGAEFSRIQIALFLHTLVTKYRWKEI 1422 G R+CVG +R+++ LFL T++ ++ K + Sbjct: 431 GKRICVGESLARMELFLFLTTILQNFKLKPL 461
>P56655:CP238_MOUSE Cytochrome P450 2C38 - Mus musculus (Mouse)| Length = 490 Score = 97.4 bits (241), Expect = 2e-19 Identities = 104/451 (23%), Positives = 194/451 (43%), Gaps = 31/451 (6%) Frame = +1 Query: 163 GRLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRL---KRYGPVFKTSLVGQPVVVSMD 333 GRLPPG P++G Q +DV F + K YGPVF L +P+VV Sbjct: 27 GRLPPGPTPFPIIGNFLQ-------IDVKNFNQSLTNFSKAYGPVFTLYLGSRPIVVLHG 79 Query: 334 AEVNRFIFQQEGKLF--RSWYP--DTANNIFGKESIASYDGSFHKYVRSFASRLF----- 486 E + G+ F R P + NN G I +G+ K R F Sbjct: 80 YEAVKEALIDHGEEFSGRGNIPMSEKINNGLG---ITFSNGNSWKETRHFTLMTLRNLGM 136 Query: 487 GLDSLRDVLLAEMDCNVTD--SLAAWAAEPAIEVKDAVANMVFDLTAKKLIGFSPEK--- 651 G ++ D + E C V + +P + A N++ + + + + Sbjct: 137 GKRNIEDRVREEAQCLVEELRKTKGSPCDPTFILSCAPCNVICSIIFQDRFHYKDKDFLM 196 Query: 652 -SRKLRKNF----DAFFQGLVSFPL---YFPGTTFYRCIQGRKNVQKVLKDLLKERLGAP 807 +KL +N + Q +FPL Y PG+ ++ ++ K ++ L + +KE + Sbjct: 197 LMKKLNENVKILSSPWLQVCNNFPLLIDYCPGS-HHKVLKNFKYIRSYLLEKVKEHQASL 255 Query: 808 EKRHG-DFLDEVVDELQSGRGVIDEKFAVDLMAALLFASFA----TVSSSLTIAMKFLSG 972 + + DF+D + + + + +++++ + + FA T S++L A+ L Sbjct: 256 DFTNPRDFIDYFLIKQKQANHIEQAEYSLENLVCTINNLFAAGTETTSTTLRYALLLLMK 315 Query: 973 HPNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAPGIFRKTL 1152 +P+V ++EE + ++ G ++ M +T + +E+ R N+ P + Sbjct: 316 YPDVTAKVQEEIDHVV-----GRHRSPCMQDRSHMPYTDAMIHEVQRFINLVPNNLPHAV 370 Query: 1153 T-DVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGG 1329 T D++ + Y IP G V+ S +V + + F +P F+P + D + FM F Sbjct: 371 TCDIKFRNYIIPKGTTVVTSLTSVLHDSKEFPNPEMFDPGHFLDANGNFKKSDYFMTFSA 430 Query: 1330 GIRLCVGAEFSRIQIALFLHTLVTKYRWKEI 1422 G R+C G +R+++ L L T++ ++ K + Sbjct: 431 GKRVCAGEGLARMELFLILTTILQNFKLKSL 461
>Q08078:CP2CP_MESAU Cytochrome P450 2C25 - Mesocricetus auratus (Golden hamster)| Length = 490 Score = 97.1 bits (240), Expect = 2e-19 Identities = 102/445 (22%), Positives = 194/445 (43%), Gaps = 26/445 (5%) Frame = +1 Query: 166 RLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEVN 345 +LPPG LP++G Q + S + F K YGPVF L +P VV E Sbjct: 28 KLPPGPTPLPIIGNFLQIDVKNISGSLTNFSKV----YGPVFTLYLGMKPTVVLHGYETV 83 Query: 346 RFIFQQEGKLF--RSWYPDTANNIFGKESIASYDGSFHKYVRSFASRLF-----GLDSLR 504 + G+ F R +P A I I +G+ K +R F+ G ++ Sbjct: 84 KEALIDHGEEFAGRGDFP-MAERINKGLGIVFSNGNRWKEIRRFSLMTLRNLGMGKRNIE 142 Query: 505 DVLLAEMDCNVTD--SLAAWAAEPAIEVKDAVANMV--------FDLTAKKLIGFSPEKS 654 D + E C V + +P + A N++ FD + + F + + Sbjct: 143 DRVQEEAQCLVEELRKTNGSPCDPTFILSCAPCNVICSIIFQNRFDYKDQDFLTFMKKVN 202 Query: 655 RKLRKNFDAFFQGLVSFPL---YFPGTTFYRCIQGRKNVQKVLKDLLKERLGAPE-KRHG 822 +R + Q +FP Y PG+ ++ + ++K + + ++E + + + Sbjct: 203 ENVRILSSPWLQVCNNFPSLIDYCPGS-HHKITKNVNYLKKYILEKIEEHQESLDIENPR 261 Query: 823 DFLDEVVDELQSGRGVIDEKFAVDLMAA----LLFASFATVSSSLTIAMKFLSGHPNVVE 990 DF+D + +L+ +F+++ + L A T S++L A+ L HP+V Sbjct: 262 DFIDYYLIKLKQANHNQQSEFSLENLTTTVSDLFGAGTETTSTTLRYALLLLLKHPHVTA 321 Query: 991 SLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAPGIFRKTLT-DVQV 1167 ++EE + ++ + + ++ M +T + +E+ R ++ P +T D++ Sbjct: 322 KVQEEIDQVVGRHRKPCM-----QDRSHMPYTDAMIHEVQRFIDLIPISLPHAVTCDIKF 376 Query: 1168 KGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGIRLCV 1347 + Y IP G V+ S +V + + F +P F+P + D++ FMPF G R+C Sbjct: 377 RDYFIPKGTTVITSLSSVLHDNKEFPNPEVFDPGHFLDKNGNFKKSDYFMPFSAGKRICA 436 Query: 1348 GAEFSRIQIALFLHTLVTKYRWKEI 1422 G +R+++ LFL T++ ++ K + Sbjct: 437 GEGLARMELFLFLTTILQNFKLKSM 461
>P17666:CP2CE_RABIT Cytochrome P450 2C14 - Oryctolagus cuniculus (Rabbit)| Length = 490 Score = 97.1 bits (240), Expect = 2e-19 Identities = 109/447 (24%), Positives = 184/447 (41%), Gaps = 27/447 (6%) Frame = +1 Query: 163 GRLPPGSMGLPLVGETFQF-FKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAE 339 G+LPPG LP++G Q FK D+ + K YG VF + +P VV E Sbjct: 27 GKLPPGPTPLPILGNILQIDFK-----DISKSLQNLSKVYGNVFTVYMGMKPTVVMYGYE 81 Query: 340 VNRFIFQQEGKLFRSWYPDTANNIFGKE-SIASYDGSFHKYVRSFAS---RLFGLD--SL 501 + G+ F N K + +G K +R F+ R FG+ S+ Sbjct: 82 AVKEALVDLGEEFSGRNLSPINKKVNKGLGVIFSNGKRWKEIRRFSLMTLRNFGMGKRSI 141 Query: 502 RDVLLAEMDCNVTD--SLAAWAAEPAIEVKDAVANMVFDLTAKKLIGFSPEKSRKLRKNF 675 D + E C V + +P + A N++ + + + E L F Sbjct: 142 EDRVQEEARCLVEELRKTNGSPCDPTFILGAAPCNVICSVIFQNRFDYKDETFLNLMGKF 201 Query: 676 DAFFQGLVS--------FPL---YFPGT--TFYRCIQGRKNVQKVLKDLLKERLGAPEKR 816 + F+ L S FP+ Y PGT T + +N VL+ + + Sbjct: 202 NENFRILNSPWLQVCNIFPILMDYLPGTHKTVFENFDYVRNF--VLEKTKEHQESLDINN 259 Query: 817 HGDFLDEVVDELQSGRGVIDEKFAVDLMAALLFASFA----TVSSSLTIAMKFLSGHPNV 984 DF+D + +++ + +F ++ + A + FA T S++L + L HP V Sbjct: 260 PRDFIDCFLIKMKQEKHNQQSEFTIENLMATVTDVFAAGTETTSTTLRYGLLLLMKHPEV 319 Query: 985 VESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAPG-IFRKTLTDV 1161 ++EE E ++ G ++ M +T +EI R N+ P + T +V Sbjct: 320 TAKVQEEIERVI-----GRHRSPCMQDRSRMPYTDATVHEIQRYINLVPNNVPHATTCNV 374 Query: 1162 QVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGIRL 1341 + + Y IP G V+ S +V + + F P F+P + D S FMPF G R+ Sbjct: 375 KFRNYFIPKGTAVLTSLTSVLHDNQEFLKPDKFDPGHFLDASGNFKKSDYFMPFSTGKRV 434 Query: 1342 CVGAEFSRIQIALFLHTLVTKYRWKEI 1422 C+G +R+++ LFL ++ + K + Sbjct: 435 CMGEALARMELFLFLTAILQNFTLKPL 461
>P24454:CP2A8_MESAU Cytochrome P450 2A8 - Mesocricetus auratus (Golden hamster)| Length = 494 Score = 97.1 bits (240), Expect = 2e-19 Identities = 112/484 (23%), Positives = 197/484 (40%), Gaps = 41/484 (8%) Frame = +1 Query: 166 RLPPGSMGLPLVGETFQFFKPSPSLDVPAFY---KQRLKRYGPVFKTSLVGQPVVV--SM 330 ++PPG LP +G + LD FY + +RYGPVF L +P V+ Sbjct: 32 KMPPGPTPLPFIGNFLE-------LDTEKFYDCLSKMRERYGPVFTIHLGPRPAVMLWGY 84 Query: 331 DAEVNRFIFQQEG------KLFRSWYPDTANNIFG---------KESIASY-DGSFHKY- 459 DA I Q E + F W+ +F + SIA+ D F K Sbjct: 85 DAVKEALIDQAEELSDRGEQAFFDWFFKGYGVVFSSGERAKQLRRFSIATLRDFGFGKRG 144 Query: 460 --VRSFASRLFGLDSLRDVLLAEMDCNVTDSLAAWAAEPAIEVKDAVANMVF-------D 612 R+ F + +LRD A +D S V + ++++VF D Sbjct: 145 IEERTIEETSFLIQALRDTNGATIDPTFYMSRT---------VSNVISSIVFGNRFEYDD 195 Query: 613 LTAKKLIGFSPEKSRKLRKNFDAFFQGLVSFPLYFPGTTF--YRCIQGRKN--VQKVLKD 780 L+G + + + F+ S + PG Y+ +QG ++ +KV ++ Sbjct: 196 KEFLSLLGMIMRSFQFMSTSTGQLFEMFYSVMKHLPGCQHQAYKEMQGLEDFIARKVEEN 255 Query: 781 LLKERLGAPEKRHGDFLDEVVDELQSGRGVIDEKFAVDLMAALLFASFATVSSSLTIAMK 960 +P FL + +E ++ R + + L FA TVS++ Sbjct: 256 QRTLDPNSPRDFIDSFLIRMQEEKKNPRTQFHMRNLLMTTLNLFFAGTETVSTTTRYGFL 315 Query: 961 FLSGHPNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAP-GI 1137 L +P++ + EE + ++ + + +E++ M +T V EI R +V P G+ Sbjct: 316 LLMKYPHIAAKMHEEIDQVIGRNRQPK-----YEDHLKMPYTEAVIYEIQRFVDVVPLGL 370 Query: 1138 FRKTLTDVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFM 1317 R T D++ + + IP G V +V +P+ F +P FNP + D+ + FM Sbjct: 371 PRSTTKDIKFRDFLIPKGTDVFPVLSSVLKDPKFFSNPNDFNPQHFSDDKGQFKKSNAFM 430 Query: 1318 PFGGGIRLCVGAEFSRIQIALFLHTLVTKYRWKEIKGGE-----VQRISEIVFPEGYHIQ 1482 PF G R C G +++++ +F T++ + +K + + Q S P + + Sbjct: 431 PFSVGKRYCFGESLAKMELFIFFTTIMQNFCFKSPQAPQDIDVTPQYFSFAAIPPKFTMS 490 Query: 1483 IIPR 1494 +PR Sbjct: 491 FLPR 494
>Q964R1:CP6J1_BLAGE Cytochrome P450 6j1 - Blattella germanica (German cockroach)| Length = 501 Score = 96.7 bits (239), Expect = 3e-19 Identities = 102/416 (24%), Positives = 185/416 (44%), Gaps = 23/416 (5%) Frame = +1 Query: 310 QPVVVSMDAEVNRFIFQQEGKLF--RSWYPDTANNIFGKESIASYDGSFHKYVRSFASRL 483 QP ++ D E+ + I ++ + F R D + + +I + G K+VR+ + Sbjct: 84 QPALLVNDLEIVKNILVKDSRNFIDRMVKVDESLSPLNANAIFALRGQKWKHVRTSLTPT 143 Query: 484 FGLDSLRDVLLAEMDCN--VTDSLAAWA-AEPAIEVKDAVANMVFDLTAKKLIGFS---- 642 F ++++ C + + +A AE + VKDAV D+TA G Sbjct: 144 FTTGKMKNMFYLVDKCGQQLVLFIEKFAKAENPVAVKDAVERFTMDVTAMCAFGIECNSL 203 Query: 643 ----PEKSRKLRKNFD-AFFQGLVSFPLYFPG--TTFYRCIQGRKNVQKVLKDL------ 783 E S L + F +F + + +F F+R ++ ++D+ Sbjct: 204 QDPKAEFSNLLHRIFQLSFTSAVANLATFFAPWVQNFFRLKLMDSEIEDRIRDIVWRAVH 263 Query: 784 LKERLGAPEKRHGDFLDEVVDELQSGRGVIDEKFAVDLMAALLFASFATVSSSLTIAMKF 963 L+E+ G EKR+ D LD +++ S +D V L A F T S +LT A+ Sbjct: 264 LREKTG--EKRN-DLLDYLMELRTSETSKLDGDDFVAQAFGFLVAGFHTSSMTLTFALYE 320 Query: 964 LSGHPNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAPGIFR 1143 LS H ++ + + E + +L E K +T+ K M + V NE R P + R Sbjct: 321 LSVHQDIQTTARTEIKDVL----EHHKKKVTYYSIKDMKYLDMVVNETLRKYPAIPFLDR 376 Query: 1144 KTLTDVQV-KGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMP 1320 + D + + +PAG V I A+H + + F P F+P R+ +++K++ +MP Sbjct: 377 RCQEDYPLTQDLMLPAGTGVYIPVYALHHDSKYFPSPAKFDPERFSEKNKQNIPHFAYMP 436 Query: 1321 FGGGIRLCVGAEFSRIQIALFLHTLVTKYRWKEIKGGEVQRISEIVFPEGYHIQII 1488 FG G R C+G F +Q+ L +++ + E+ + RI I+ P+ +++ + Sbjct: 437 FGEGPRNCIGMRFGSMQVKAALIHILSNF---EVSPCKETRIPLIIDPKPFNLMAL 489
>Q09736:CP51_SCHPO Probable cytochrome P450 51 - Schizosaccharomyces pombe (Fission| yeast) Length = 495 Score = 96.7 bits (239), Expect = 3e-19 Identities = 116/508 (22%), Positives = 205/508 (40%), Gaps = 41/508 (8%) Frame = +1 Query: 70 VAFASLCGLAAVVAGW-LAHCVYKWTNPACSTGRLPPGSMGLPLVGETFQFFKPSPSLDV 246 +AF+ + L ++ W + + + + T+ ++ R P +P VG + +D Sbjct: 1 MAFSLVSILLSIALAWYVGYIINQLTSR--NSKRPPIVFHWIPFVGSAVAY-----GMDP 53 Query: 247 PAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEVNRFIFQQEGKLF----RSWYPDTANNIF 414 F+++ +YG VF +G+ + + + N F+F GKL Y +F Sbjct: 54 YVFFRECRAKYGDVFTFVCMGRKMTAFLGVQGNDFLFN--GKLADLNAEEAYSHLTTPVF 111 Query: 415 GKESIASYDGSFHKYV--RSFASRLFGLDSLRD---VLLAEMDCNVTDSLAAWAAEPAIE 579 GK+ + YD H ++ + F G R ++L EMD ++ S Sbjct: 112 GKDVV--YDIPNHVFMEHKKFIKSGLGFSQFRSYVPLILNEMDAFLSTSPDFGPG----- 164 Query: 580 VKDAVANMVFDLTAKKLIGFSPE-KSRKLRKNFDAFF--------QGLVSFPLYFPGTTF 732 K+ VA+++ + + S + ++RK FDA F QG FP Sbjct: 165 -KEGVADLLKTMPVMTIYTASRTLQGAEVRKGFDAGFADLYHDLDQGFSPVNFVFPWLPL 223 Query: 733 ---YRCIQGRKNVQKVLKDLLKERLGAPEKRHGDFLDEVVD-ELQSGRGVIDEKFAVDLM 900 R + K +QK ++K+R + E D + ++ + + GR + + + A +M Sbjct: 224 PRNRRRDRAHKIMQKTYLKIIKDRRSSTENPGTDMIWTLMSCKYRDGRPLKEHEIA-GMM 282 Query: 901 AALLFASFATVSSSLTIAMKFLSGHPNVVESLKEEHEAILKKREEGAKSGITWEEYKSMT 1080 ALL A T ++++ + L P ++E L EE +KR G + +++YK M Sbjct: 283 IALLMAGQHTSAATIVWVLALLGSKPEIIEMLWEE-----QKRVVGENLELKFDQYKDMP 337 Query: 1081 FTAQVTNEISRVSNVAPGIFRKTLTDVQVKG--YTIPAGWLVMISPMAVHLNPELFEDPL 1254 V E R+ RK D+ V G IPA ++ +P E F Sbjct: 338 LLNYVIQETLRLHPPIHSHMRKVKRDLPVPGSKIVIPANNYLLAAPGLTATEEEYFTHAT 397 Query: 1255 TFNPWRWQDESKKSTMLKN---------------FMPFGGGIRLCVGAEFSRIQIALFLH 1389 F+P RW D + + ++PFG G C+G +F+ + ++ + Sbjct: 398 DFDPKRWNDRVNEDENAEQIDYGYGLVTKGAASPYLPFGAGRHRCIGEQFAYMHLSTIIS 457 Query: 1390 TLVTKYRWKEI-KGGEVQRISEIVFPEG 1470 V Y W I K V S + P G Sbjct: 458 KFVHDYTWTLIGKVPNVDYSSMVALPLG 485
>Q9JMA7:CP341_MOUSE Cytochrome P450 3A41 - Mus musculus (Mouse)| Length = 504 Score = 96.3 bits (238), Expect = 4e-19 Identities = 101/440 (22%), Positives = 186/440 (42%), Gaps = 26/440 (5%) Frame = +1 Query: 175 PGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEVNRFI 354 PG LP +G ++K D+ + K YG + P+ V D E+ + + Sbjct: 39 PGPTPLPFLGTVLNYYKGLWKFDMECYEK-----YGKTWGLFDGQMPLFVITDPEMIKNV 93 Query: 355 FQQEG-KLFRSWYPDTANNIFGKESIASYDGSFHKYVRSFASRLFGLDSLRDVL-LAEMD 528 +E +F + I K S D + +Y R+ S F L+++ + E Sbjct: 94 LVKECFSVFTNRREFGPVGIMSKAISISKDEEWKRY-RALLSPTFTSGKLKEMFPVIEQY 152 Query: 529 CNVTDSLAAWAAEPA--IEVKDAVANMVFDLTAKKLIGFSP-----------EKSRKLRK 669 ++ AE + +KD + D+ G + EK++ + + Sbjct: 153 GDILVKYLMQEAEKGKPVTMKDVLGAYSIDVITSTSFGVNVDSLNNPEDPFVEKAKGILR 212 Query: 670 N--FDAFFQGLVSFPLYFPGTTFYR-CIQGRKNVQ---KVLKDLLKERLGAPEKRHGDFL 831 FD +V FP P C+ + +++ K + + + RL + +K DFL Sbjct: 213 VDFFDPLVFSVVLFPFLTPVYEMLNICMFPKDSIEFFKKFVNRMKESRLDSKQKHRVDFL 272 Query: 832 DEVVDELQSGRGVIDEKFAVDL-----MAALLFASFATVSSSLTIAMKFLSGHPNVVESL 996 +++ + + K D+ +FA + T SS+L+ + L+ HP++ + L Sbjct: 273 QLMMNAHNNSKDKDSHKALSDMEITAQSIVFIFAGYETTSSTLSFTLYCLATHPDIQKKL 332 Query: 997 KEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAPGIFRKTLTDVQVKGY 1176 +EE + L K+ T++ M + V NE R+ + + R DV++ G Sbjct: 333 QEEIDETLPN-----KAPPTYDTVMEMEYLDMVLNETLRLYPIGNRLERFCKKDVELNGV 387 Query: 1177 TIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGIRLCVGAE 1356 IP G VMI A+H +P+ + +P F P R+ E+K S +MPFG G R C+G Sbjct: 388 YIPKGSTVMIPSYALHHDPQHWPEPEEFQPERFSKENKGSIDPYLYMPFGIGPRNCIGMR 447 Query: 1357 FSRIQIALFLHTLVTKYRWK 1416 F+ + + L L ++ + ++ Sbjct: 448 FAFMTMKLALTKVMQNFSFQ 467
>P05181:CP2E1_HUMAN Cytochrome P450 2E1 - Homo sapiens (Human)| Length = 493 Score = 96.3 bits (238), Expect = 4e-19 Identities = 118/504 (23%), Positives = 208/504 (41%), Gaps = 33/504 (6%) Frame = +1 Query: 82 SLCGLAAVVAGWLAHC--VYKWTNPACSTGRLPPGSMGLPLVGETFQFFKPSPSLDVPAF 255 S G+ + W A V W S+ LPPG LP++G FQ ++P Sbjct: 2 SALGVTVALLVWAAFLLLVSMWRQ-VHSSWNLPPGPFPLPIIGNLFQL----ELKNIPKS 56 Query: 256 YKQRLKRYGPVFKTSLVGQPVVVSMDAEVNRFIFQQEGKLFRSWYPDTANNIFGKESIAS 435 + + +R+GPVF + Q +VV + + F A + I Sbjct: 57 FTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAHRDRGIIF 116 Query: 436 YDGSFHKYVRSFAS---RLFGLDSLRDVLLAEMDCN-VTDSLAAWAAEP---AIEVKDAV 594 +G K +R F+ R +G+ + + + + + ++L +P + A Sbjct: 117 NNGPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAP 176 Query: 595 ANMVFDLTAKKLIGFSPEKSRKLRKNFDAFFQGLVSFP---LY--FPGTTFYRCIQGRKN 759 N++ D+ +K ++ EK +L F+ F L+S P LY FP Y RK Sbjct: 177 CNVIADILFRKHFDYNDEKFLRLMYLFNENFH-LLSTPWLQLYNNFPSFLHYLPGSHRKV 235 Query: 760 VQKVLKDLLKERLGAPEKRHGDFLDE---------VVDELQSGRGVIDEKFAVD----LM 900 ++ V + +KE + K H LD ++ E++ + + + +D + Sbjct: 236 IKNVAE--VKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTV 293 Query: 901 AALLFASFATVSSSLTIAMKFLSGHPNVVESLKEEHEAILKKREEGAKSGITWEEYKSMT 1080 A L FA T S++L + L +P + E L EE + ++ G ++ + M Sbjct: 294 ADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVI-----GPSRIPAIKDRQEMP 348 Query: 1081 FTAQVTNEISRVSNVAPGIFRKTLT-DVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLT 1257 + V +EI R + P T D +GY IP G +V+ + +V + + F DP Sbjct: 349 YMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEK 408 Query: 1258 FNPWRWQDESKKSTMLKNFMPFGGGIRLCVGAEFSRIQIALFLHTLVTKYRWKEIKGGEV 1437 F P + +E+ K F PF G R+C G +R+++ L L ++ + K + + Sbjct: 409 FKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKD 468 Query: 1438 QRISEI-----VFPEGYHIQIIPR 1494 +S I P Y + +IPR Sbjct: 469 IDLSPIHIGFGCIPPRYKLCVIPR 492
>P33273:CP255_RAT Cytochrome P450 2C55 - Rattus norvegicus (Rat)| Length = 490 Score = 96.3 bits (238), Expect = 4e-19 Identities = 107/446 (23%), Positives = 186/446 (41%), Gaps = 28/446 (6%) Frame = +1 Query: 163 GRLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEV 342 G+LPPG LP++G Q D+ + K YGPVF +P VV E Sbjct: 27 GKLPPGPTPLPIIGNILQI----DVKDISKSFSYFSKIYGPVFTLYFGPKPTVVVHGYEA 82 Query: 343 NRFIFQQEGKLF--RSWYP--DTANNIFGKESIASYDGSFHKYVRSFAS---RLFGLD-- 495 + G+ F R +P + NN G + +G+ K +R F+ R FG+ Sbjct: 83 VKEALDDLGEEFSGRGSFPIVERMNNGLG---LIFSNGTKWKELRHFSLMTLRNFGMGKR 139 Query: 496 SLRDVLLAEMDCNVTD--SLAAWAAEPAIEVKDAVANMVFDLTAKKLIGFSPEK----SR 657 S+ D + E C V + +P + A +N++ + + E Sbjct: 140 SIEDRIQEEASCLVEELRKTNGSLCDPTFILSCAPSNVICSVVFHNRFDYKDENFLNLME 199 Query: 658 KLRKNFDAF-------FQGLVSFPLYFPGTTFYRCIQGRKNVQKVLKDLLKERLGAPEKR 816 KL +NF L +F Y PG+ R I+ ++ + +KE + Sbjct: 200 KLNENFKILNSPWMQVCNALPAFIDYLPGS-HNRVIKNFAEIKSYILRRVKEHQETLDMD 258 Query: 817 HG-DFLDEVVDELQSGRGVIDEKFAVDLMAA----LLFASFATVSSSLTIAMKFLSGHPN 981 + DF+D + +++ + +F ++ + A + A T S++L + L H Sbjct: 259 NPRDFIDCFLIKMEQEKHNPRTEFTIESLMATVSDVFVAGSETTSTTLRYGLLLLLKHTE 318 Query: 982 VVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAPGIFRKTLT-D 1158 V ++EE + ++ + T M +T + +EI R N+ P T + Sbjct: 319 VTAKVQEEIDHVIGRHRRPCMQDRT-----RMPYTDAMVHEIQRYINLIPNNVPHAATCN 373 Query: 1159 VQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGIR 1338 V+ + Y IP G ++ S +V + + F +P F+P + DE+ FMPF G R Sbjct: 374 VRFRNYVIPKGTDLVTSLTSVLHDDKEFPNPEVFDPGHFLDENGNFKKSDYFMPFSTGKR 433 Query: 1339 LCVGAEFSRIQIALFLHTLVTKYRWK 1416 +CVG +R+++ L L T+V + K Sbjct: 434 MCVGEALARMELFLLLTTIVQNFNLK 459
>O18992:CP2DJ_CALJA Cytochrome P450 2D19 - Callithrix jacchus (Common marmoset)| Length = 497 Score = 95.9 bits (237), Expect = 5e-19 Identities = 111/482 (23%), Positives = 199/482 (41%), Gaps = 39/482 (8%) Frame = +1 Query: 166 RLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVV--SMDAE 339 R PPG M LP +G + P + Q +R+G VF L PVVV ++A Sbjct: 32 RYPPGPMPLPGLGNLLHV----DFQNTPNSFNQLRRRFGDVFSLQLAWTPVVVLNGLEAV 87 Query: 340 VNRFIFQQEGKLFRSWYPDTANNIFGKES----IASYDGSFHKYVRSFASRL----FGLD 495 + + E R P T FG S +A Y ++ + R S L G Sbjct: 88 REALVTRGEDTADRPPVPITEMLGFGPHSQGLFLARYGPAWREQRRFSVSTLRNLGLGKK 147 Query: 496 SLRDVLLAEMD--CNVTDSLAAWAAEPAIEVKDAVANMVFDLTAKKLIGFSP-------- 645 SL + E C A P + AV+N++ LT ++ ++ Sbjct: 148 SLEQWVTEEATYLCAAFADHAGRPFRPNGLLDKAVSNVIASLTCRRRFEYNDPCLLRLLD 207 Query: 646 -------EKSRKLRKNFDAFFQGLVSFPLYFPGTTFYRCIQGRKNVQKVLKDLLKERLGA 804 E+S LR+ +A + L PG + ++ +K L +LL E Sbjct: 208 LTMEGLKEESGLLREVLNA-----IPVLLRIPGLAG-KVLRSQKAFLAQLDELLTEHRMT 261 Query: 805 --PEKRHGDFLDEVVDELQSGRGVIDEKFAVD----LMAALLFASFATVSSSLTIAMKFL 966 P + D + + E++ +G + F + ++A L A T S +L + + Sbjct: 262 WDPAQPPRDLTEAFLAEMEKTKGNPESSFNDENLHLVVADLFSAGMVTTSITLAWGLLLM 321 Query: 967 SGHPNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAP-GIFR 1143 HP+V +++E + ++ + T+ M +T V +E+ R +++ P G+ Sbjct: 322 ILHPDVQRRVQQEIDDVIGRVRRPEMGDQTY-----MPYTTAVIHEVQRFADIVPLGVTH 376 Query: 1144 KTLTDVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPF 1323 T D++V+G+ IP G + + +V + +E P F+P + D + + F+PF Sbjct: 377 MTSRDIEVQGFLIPKGTTLFTNLSSVLKDEANWEKPFRFHPEHFLDAQGRFVKPEAFLPF 436 Query: 1324 GGGIRLCVGAEFSRIQIALFLHTLVTKYRWKEIKGGEVQRISEIVF-----PEGYHIQII 1488 G R C+G +R+++ LF L+ ++ + + G+ + VF P Y + + Sbjct: 437 SAGRRACLGEPLARMELFLFFTCLLQRFSF-SVPAGQPRPSPHGVFAFLVTPSPYELCAV 495 Query: 1489 PR 1494 PR Sbjct: 496 PR 497
>P05178:CP2C6_RAT Cytochrome P450 2C6 - Rattus norvegicus (Rat)| Length = 490 Score = 95.9 bits (237), Expect = 5e-19 Identities = 106/448 (23%), Positives = 182/448 (40%), Gaps = 28/448 (6%) Frame = +1 Query: 163 GRLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEV 342 G+LPPG + LP++G FQ + + + +F K YGPVF +P V+ E Sbjct: 27 GKLPPGPIPLPIIGNIFQLNVKNITQSLTSFSKV----YGPVFTLYFGTKPTVILHGYEA 82 Query: 343 NRFIFQQEGKLF--RSWYPDTANNIFGKESIASYDGSFHKYVRSFASRLF-----GLDSL 501 + G+ F R +P A I I G+ K +R F G ++ Sbjct: 83 VKEALIDHGEEFAERGSFP-VAEKINKDLGIVFSHGNRWKEIRRFTLTTLRNLGMGKRNI 141 Query: 502 RDVLLAEMDCNVTD--SLAAWAAEPAIEVKDAVANMVFDLTAKKLIGFSPEK----SRKL 663 D + E C V + +P + A N++ + + + + KL Sbjct: 142 EDRVQEEARCLVEELRKTNGSPCDPTFILGCAPCNVICSIIFQNRFDYKDQDFLNLMEKL 201 Query: 664 RKNFDAFFQGLVSFPLYFPGTTFYRCIQGR----KNVQKVLKDLLK------ERLGAPEK 813 +N F +FP Y C KNV + LLK E L Sbjct: 202 NENMKILSSPWTQFCSFFPVLIDY-CPGSHTTLAKNVYHIRNYLLKKIKEHQESLDVTNP 260 Query: 814 RHGDFLDEVVDELQSGRGVIDEKFAVDLMAA----LLFASFATVSSSLTIAMKFLSGHPN 981 R DF+D + + + +F ++ ++ L A T S++L A+ L P Sbjct: 261 R--DFIDYYLIKWKQENHNPHSEFTLENLSITVTDLFGAGTETTSTTLRYALLLLLKCPE 318 Query: 982 VVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAPGIFRKTLT-D 1158 V ++EE + ++ K ++ M +T +E+ R ++ P +T D Sbjct: 319 VTAKVQEEIDRVVGKHRSPCM-----QDRSRMPYTDAHDHEVQRFIDLIPTNLPHAVTCD 373 Query: 1159 VQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGIR 1338 ++ + Y IP G ++ S +V + + F DP F+P + D + K FMPF G R Sbjct: 374 IKFRNYLIPKGTTIITSLSSVLHDSKEFPDPEIFDPGHFLDGNGKFKKSDYFMPFSAGKR 433 Query: 1339 LCVGAEFSRIQIALFLHTLVTKYRWKEI 1422 +C G +R+++ LFL T++ ++ K + Sbjct: 434 MCAGEGLARMELFLFLTTILQNFKLKSV 461
>Q9PVE8:C330_FUNHE Cytochrome P450 3A30 - Fundulus heteroclitus (Killifish) (Mummichog)| Length = 496 Score = 95.9 bits (237), Expect = 5e-19 Identities = 105/422 (24%), Positives = 181/422 (42%), Gaps = 27/422 (6%) Frame = +1 Query: 253 FYKQRLKRYGPVFKTSLVGQPVVVSMDAEVNRFIFQQEGKLFRSWYPDTANN--IFGKES 426 F ++ K+YG V+ QPV+ D E+ + + +E F + + N ++ S Sbjct: 59 FDEECKKKYGKVWGIYDGRQPVLCVTDPEIIKAVLVKECLSFFTNRRNFRLNGPLYDAVS 118 Query: 427 IASYDGSFHKYVRSFASRLFGLDSLRDV--LLAEMDCNVTDSLAAWA-AEPAIEVK---- 585 IA D K +RS S F L+++ ++ N+ S+ A + +++K Sbjct: 119 IAEDDQ--WKRIRSVLSPSFTSGRLKEMFEIMKNHSANLIRSMKKKADKDEPLDLKEFFG 176 Query: 586 ----DAVANMVFDLTAKKLIGFSPEKSRKLRK--NFD---AFFQGLVSFPLYFPGTTFYR 738 D V + F + L S ++K FD F + FP P + Sbjct: 177 SYSMDVVTSTAFSVDIDSLNNPSDPFVTNIKKMLKFDFLNPLFLAVAFFPFLGPILEKFE 236 Query: 739 CIQGRKNVQKV----LKDLLKERLGAPEKRHGDFLDEVVDELQSGRGVIDEKFAVD---- 894 K+V L+ + R + +K DFL ++D Q G +K D Sbjct: 237 LSFFPKSVTDFFYASLEKIKSNREASQQKSRVDFLQLMIDS-QKNSGAQQDKSLTDHEIL 295 Query: 895 -LMAALLFASFATVSSSLTIAMKFLSGHPNVVESLKEEHEAILKKREEGAKSGITWEEYK 1071 +FA + T SSSLT L+ +P V++ L+EE +A K+ + ++ Sbjct: 296 SQSMIFIFAGYETSSSSLTFLAYNLATNPEVMKKLQEEIDATFPN-----KAPVHYQPLM 350 Query: 1072 SMTFTAQVTNEISRVSNVAPGIFRKTLTDVQVKGYTIPAGWLVMISPMAVHLNPELFEDP 1251 M + V NE R+ +A + R V++ G IP +VMI +H +PE++ +P Sbjct: 351 EMEYLDCVINESLRLFPIAARLERVAKAAVEINGVVIPKDMVVMIPTWPLHRDPEIWPEP 410 Query: 1252 LTFNPWRWQDESKKSTMLKNFMPFGGGIRLCVGAEFSRIQIALFLHTLVTKYRWKEIKGG 1431 F P R+ ++K + +MPFG G R C+G F+ + I L + ++ +Y + K Sbjct: 411 EAFKPERFSKKNKDNIDPYIYMPFGSGPRNCIGMRFALVLIKLAVVEILQQYSFSVCKET 470 Query: 1432 EV 1437 EV Sbjct: 471 EV 472
>Q9QUJ1:CP2DS_MESAU Cytochrome P450 2D28 - Mesocricetus auratus (Golden hamster)| Length = 500 Score = 95.5 bits (236), Expect = 6e-19 Identities = 110/493 (22%), Positives = 206/493 (41%), Gaps = 34/493 (6%) Frame = +1 Query: 118 LAHCVYKWTNPACSTGRLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKT 297 L H +W + R PPG + LPL+G Q + V + YG VF Sbjct: 25 LLHRRQRWAS------RYPPGPVPLPLLGNLLQVDLKNMQYSVHKLQQH----YGDVFSL 74 Query: 298 SLVGQPVVVSMDAEVNRFIFQQEGKLF--RSWYPDTANNIFGKES----IASYDGSFHKY 459 + + +V+ + R + G+ R P + G ++ +A Y + + Sbjct: 75 QMAWKHMVMINGLKAVREVLVNYGEYTADRPKIPIYEHGSLGPKARGVILAPYGPEWREQ 134 Query: 460 VRSFASRL----FGLDSLRDVLLAEMD--CNVTDSLAAWAAEPAIEVKDAVANMVFDLTA 621 R S L G SL + E C+ A P+ + AV N++ L Sbjct: 135 RRFSVSTLRNLGLGKKSLEQWVTDEAGHLCDAFKDQAGRPFNPSTLLNKAVCNVITSLIF 194 Query: 622 KKLIGFSPEKSRKLRK-------NFDAFFQGLVS-FP--LYFPGTTFYRCIQGRKNVQKV 771 + + ++ + N F +++ FP L+ PG F + G+K + Sbjct: 195 ARRFEYEDANLIRMLRLLEEALTNISGFIPEILNTFPVLLHIPGL-FDKVFSGQKTFAAI 253 Query: 772 LKDLLKE--RLGAPEKRHGDFLDEVVDELQSGRGVIDEKFAVD----LMAALLFASFATV 933 + +LL E R PE+ D + E++ +G + F ++ L A + Sbjct: 254 VDNLLTENRRTWDPEQPPRGLTDAFLAEMEKAKGNPESSFNDQNLRMVVNDLFIAGTVST 313 Query: 934 SSSLTIAMKFLSGHPNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISR 1113 S++L+ A+ F+ +P+V +++E + IL G + M +T V +E+ R Sbjct: 314 STTLSWALLFMIQYPDVQRRVQQEIDDIL-----GPGRSPEMADQARMPYTNAVIHEVQR 368 Query: 1114 VSNVAP-GIFRKTLTDVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESK 1290 +++AP + T D++V+G+ IP G ++ + +V + ++E PL F+P + D Sbjct: 369 FADIAPLNLPCITSRDIEVQGFLIPKGTTLITNLSSVLKDETVWEKPLHFHPEHFLDAQG 428 Query: 1291 KSTMLKNFMPFGGGIRLCVGAEFSRIQIALFLHTLVTKYRWKEIKGGEVQRISEIVF--- 1461 + FMPF G R C+G +R+++ LF L+ ++ + + G+ + +V Sbjct: 429 CFVKQEAFMPFSAGRRACLGEPLARMELFLFFTCLLQRFSF-SVPAGQPRPSDHVVLGVL 487 Query: 1462 --PEGYHIQIIPR 1494 P Y + +PR Sbjct: 488 KSPAPYQLCAVPR 500
>Q64403:CP2DG_CAVPO Cytochrome P450 2D16 - Cavia porcellus (Guinea pig)| Length = 500 Score = 95.5 bits (236), Expect = 6e-19 Identities = 110/451 (24%), Positives = 191/451 (42%), Gaps = 30/451 (6%) Frame = +1 Query: 166 RLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLK-RYGPVFKTSLVGQPVVV--SMDA 336 R PPG + +P +G Q + A+ +L+ ++G VF V PVVV + A Sbjct: 35 RYPPGPVPVPGLGNLLQV-----DFENMAYSCDKLRHQFGDVFSLQFVWTPVVVVNGLLA 89 Query: 337 EVNRFIFQQEGKLFRSWYPDTANNIFGKES---IASYDGSFHKYVRSFAS---RLFGLD- 495 + R P A FG ++ I +Y G + R F+ R FGL Sbjct: 90 VREALVNNSTDTSDRPTLPTNALLGFGPKAQGVIGAYYGPAWREQRRFSVSSLRNFGLGK 149 Query: 496 -SLRDVLLAEMDCNVTDSLAAWAAEPAIE---VKDAVANMV--------FDLTAKKLIGF 639 SL + E C + + A +P + AV N++ FD ++ Sbjct: 150 KSLEQWVTEEAAC-LCAAFTNHAGQPFCPKALLNKAVCNVISSLIYARRFDYDDPMVLRL 208 Query: 640 SPEKSRKLRKNFDAFFQGLVSFPLYFPGTTFYRCIQGRKNVQKVLKD--LLKERLG-APE 810 LR+N Q L S PL + + L D L + G AP+ Sbjct: 209 LEFLEETLRENSSLKIQVLNSIPLLLRIPCVAAKVLSAQRSFIALNDKLLAEHNTGWAPD 268 Query: 811 KRHGDFLDEVVDELQSGRGVIDEKFAVD----LMAALLFASFATVSSSLTIAMKFLSGHP 978 + D D + E+ +G + F + L++ L A T S +L+ A+ + HP Sbjct: 269 QPPRDLTDAFLTEMHKAQGNSESSFNDENLRLLVSDLFGAGMVTTSVTLSWALLLMILHP 328 Query: 979 NVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAP-GIFRKTLT 1155 +V ++EE + ++ G + M FT V +E+ R +++ P G+ T Sbjct: 329 DVQRHVQEEIDEVI-----GQVRCPEMADQAHMPFTNAVIHEVQRFADIVPMGVPHMTSR 383 Query: 1156 DVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGI 1335 D +V+G+ IP G ++ + +V + ++E PL F+P + D + + FMPF G Sbjct: 384 DTEVQGFLIPKGTMLFTNLSSVLKDETVWEKPLHFHPGHFLDAEGRFVKREAFMPFSAGP 443 Query: 1336 RLCVGAEFSRIQIALFLHTLVTKYRWKEIKG 1428 R+C+G +R+++ LF +L+ ++ + +G Sbjct: 444 RICLGEPLARMELFLFFTSLLQRFSFSVPEG 474
>Q64458:CP2CT_MOUSE Cytochrome P450 2C29 - Mus musculus (Mouse)| Length = 490 Score = 95.5 bits (236), Expect = 6e-19 Identities = 105/474 (22%), Positives = 202/474 (42%), Gaps = 31/474 (6%) Frame = +1 Query: 163 GRLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEV 342 G+LPPG LP++G Q + S F K YGPVF L +P V+ E Sbjct: 27 GKLPPGPTPLPIIGNFLQIDVKNISQSFTNFSKA----YGPVFTLYLGSKPTVILHGYEA 82 Query: 343 NRFIFQQEGKLF--RSWYPDTANNIFGKESIASYDGSFHKYVRSFASRLF-----GLDSL 501 + G+ F R +P A I + +G+ K +R F G ++ Sbjct: 83 VKEALIDRGEEFAGRGSFP-MAEKIIKGFGVVFSNGNRWKEMRRFTLMTLRNLGMGKRNI 141 Query: 502 RDVLLAEMDCNVTD--SLAAWAAEPAIEVKDAVANMV--------FDLTAKKLIGFSPEK 651 D + E C V + +P + A N++ FD K+ + + Sbjct: 142 EDRVQEEAQCLVEELRKTKGSPCDPTFILSCAPCNVICSIIFQNRFDYKDKEFLILMDKI 201 Query: 652 SRKLRKNFDAFFQGLVSFPL---YFPGTTFYRCIQGRKNVQKVLKDLLKERLGAPEKRHG 822 + ++ + Q SFP Y PG+ ++ ++ ++ L + +KE + + + Sbjct: 202 NENVKILSSPWLQVCNSFPSLIDYCPGS-HHKIVKNFNYLKSYLLEKIKEHKESLDVTNP 260 Query: 823 -DFLDEVVDELQSGRGVIDEKFAVDLMAA----LLFASFATVSSSLTIAMKFLSGHPNVV 987 DF+D + + + + +F+++ +A+ L A T S++L A+ L +P+V Sbjct: 261 RDFIDYYLIKQKQVNHIEQSEFSLENLASTINDLFGAGTETTSTTLRYALLLLLKYPDVT 320 Query: 988 ESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAPGIFRKTLT-DVQ 1164 ++EE + ++ G ++ M +T + +E+ R ++ P +T D++ Sbjct: 321 AKVQEEIDRVV-----GRHRSPCMQDRSHMPYTDAMIHEVQRFIDLLPTSLPHAVTCDIK 375 Query: 1165 VKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGIRLC 1344 + Y IP G V+ S +V + + F +P F+P + + + FMPF G R+C Sbjct: 376 FRKYLIPKGTTVITSLSSVLHDSKEFPNPEMFDPGHFLNANGNFKKSDYFMPFSTGKRIC 435 Query: 1345 VGAEFSRIQIALFLHTLVTKYRWKEIKGGEVQRISEIV-----FPEGYHIQIIP 1491 G +R+++ L L T++ ++ K + + I+ ++ P Y + IP Sbjct: 436 AGEGLARMELFLILTTILQNFKLKSLVHPKEIDITPVMNGFASLPPPYQLCFIP 489
>P00181:CP2C2_RABIT Cytochrome P450 2C2 - Oryctolagus cuniculus (Rabbit)| Length = 490 Score = 95.5 bits (236), Expect = 6e-19 Identities = 112/455 (24%), Positives = 195/455 (42%), Gaps = 35/455 (7%) Frame = +1 Query: 163 GRLPPGSMGLPLVGETFQF-FKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAE 339 G+LPPG P++G Q FK D+ K YGPVF L +P VV E Sbjct: 27 GKLPPGPTPFPILGNVLQLDFK-----DLSKSLTNLSKVYGPVFTVYLGMKPTVVVHGYE 81 Query: 340 VNRFIFQQEGKLF--RSWYPDTA--NNIFGKESIASYDGSFHKYVRSFAS---RLFGLD- 495 + G RS + TA N FG + +G R F+ R FG+ Sbjct: 82 AVKEALVDLGHELSGRSRFLVTAKLNKGFG---VIFSNGKRWTETRRFSLMTLRNFGMGK 138 Query: 496 -SLRDVLLAEMDCNVTD--SLAAWAAEPAIEVKDAVANMVFDLTAKKLIGFSPEKSRKLR 666 S+ + + E C V + A +P + A N++ + + ++ + L Sbjct: 139 RSIEERVQEEAHCLVEELRKTNASPCDPTFILGAAPCNVICSVIFQNRFDYTDQDFLSLM 198 Query: 667 KNFDAFFQGLVS--------FPL---YFPGTTFYRCIQGRKNVQKV--LKDLLKERLGAP 807 F+ F+ L S FP+ YFPG+ RK V+ + +K+ + E++ Sbjct: 199 GKFNENFKILNSPWVQFCNCFPILFDYFPGSH-------RKAVKNIFYVKNYITEQIKEH 251 Query: 808 EK-----RHGDFLDEVVDELQSGRGVIDEKFAVD----LMAALLFASFATVSSSLTIAMK 960 +K DF+D + +++ + +F ++ ++ + A T S++L + Sbjct: 252 QKSLDINNPRDFIDCFLIKMEQEKCNQQSEFTIENLLTTVSDVFMAGTETTSTTLRYGLL 311 Query: 961 FLSGHPNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAPG-I 1137 L HP V+ ++EE E ++ G ++ M +T +EI R N+ P + Sbjct: 312 LLMKHPEVIAKVQEEIERVI-----GRHRSPCMQDRSRMPYTDATVHEIQRYINLIPNNV 366 Query: 1138 FRKTLTDVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFM 1317 T+ +++ + Y IP G V+ S +V + + F +P F+P + D S FM Sbjct: 367 PHTTICNLKFRNYLIPKGTDVLTSLSSVLHDDKEFPNPDRFDPGHFLDASGNFRKSDYFM 426 Query: 1318 PFGGGIRLCVGAEFSRIQIALFLHTLVTKYRWKEI 1422 PF G R+CVG +R+++ LFL ++ + K + Sbjct: 427 PFSTGKRVCVGEALARMELFLFLTAILQNFTPKPL 461
>P20812:CP2A3_RAT Cytochrome P450 2A3 - Rattus norvegicus (Rat)| Length = 494 Score = 95.5 bits (236), Expect = 6e-19 Identities = 105/464 (22%), Positives = 190/464 (40%), Gaps = 45/464 (9%) Frame = +1 Query: 160 TGRLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLK---RYGPVFKTSLVGQPVVVSM 330 +G+LPPG LP +G Q L+ Y +K RYGPVF L + VVV Sbjct: 30 SGKLPPGPTPLPFIGNYLQ-------LNTEKMYSSLMKISQRYGPVFTIHLGPRRVVVLC 82 Query: 331 DAEVNRFIFQQEGKLFRSWYPDTANNIFGKESIASYDGSFHKYVRSFAS-------RLFG 489 E + D A G+ A++D F Y +F+S R F Sbjct: 83 GQEA-----------VKEALVDQAEEFSGRGEQATFDWLFKGYGVAFSSGERAKQLRRFS 131 Query: 490 LDSLRDVLLAEMDCNVTDSLAAWAA--------------EPAIEVKDAVANMV------- 606 + +LRD + + + + + A +P + V+N++ Sbjct: 132 IATLRDFGVGKR--GIEERIQEEAGFLIESFRKTNGALIDPTFYLSRTVSNVISSIVFGD 189 Query: 607 -FDLTAKKLIG----------FSPEKSRKLRKNFDAFFQGLVSFPLYFPGTTFYRCIQGR 753 FD K+ + F+ + +L + F + + L P ++ +QG Sbjct: 190 RFDYEDKEFLSLLRMMLGSFQFTATSTGQLYEMFSSVMKHLPG-----PQQQAFKELQGL 244 Query: 754 KN--VQKVLKDLLKERLGAPEKRHGDFLDEVVDELQSGRGVIDEKFAVDLMAALLFASFA 927 ++ +KV ++ +P FL +++E ++ K V L FA Sbjct: 245 EDFITKKVEQNQRTLDPNSPRDFIDSFLIRMLEEKKNPNTEFYMKNLVLTTLNLFFAGTE 304 Query: 928 TVSSSLTIAMKFLSGHPNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEI 1107 TVS++L L HP++ + EE + ++ + + +E+ M +T V +EI Sbjct: 305 TVSTTLRYGFLLLMKHPDIEAKVHEEIDRVIGRNRQAK-----YEDRMKMPYTEAVIHEI 359 Query: 1108 SRVSNVAP-GIFRKTLTDVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDE 1284 R +++ P G+ R+ D + + + +P G V +V +P+ F +P FNP + D+ Sbjct: 360 QRFADMIPMGLARRVTKDTKFREFLLPKGTEVFPMLGSVLKDPKFFSNPNDFNPKHFLDD 419 Query: 1285 SKKSTMLKNFMPFGGGIRLCVGAEFSRIQIALFLHTLVTKYRWK 1416 + F+PF G R C G +R+++ LFL ++ + +K Sbjct: 420 KGQFKKSDAFVPFSIGKRYCFGEGLARMELFLFLTNIMQNFCFK 463
>P04800:CP3A1_RAT Cytochrome P450 3A1 - Rattus norvegicus (Rat)| Length = 504 Score = 95.1 bits (235), Expect = 8e-19 Identities = 101/450 (22%), Positives = 189/450 (42%), Gaps = 29/450 (6%) Frame = +1 Query: 175 PGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEVNRFI 354 PG LP G ++ DV K+YG ++ P+ D E+ + + Sbjct: 39 PGPKPLPFFGTVLNYYMGLWKFDVECH-----KKYGKIWGLFDGQMPLFAITDTEMIKNV 93 Query: 355 FQQEG-KLFRSWYPDTANNIFGKESIASYDGSFHKYVRSFASRLFGLDSLRDVLLAEMDC 531 +E +F + I GK + D + +Y R+ S F L+++ + Sbjct: 94 LVKECFSVFTNRRDFGPVGIMGKAVSVAKDEEWKRY-RALLSPTFTSGRLKEMF--PIIE 150 Query: 532 NVTDSLAAWAAEPAIEVKDAVANMVFDLTAKKLIGFSP----------------EKSRKL 663 D L + + A K VF + +I + EK++KL Sbjct: 151 QYGDILVKYLKQEAETGKPVTMKKVFGAYSMDVITSTSFGVNVDSLNNPKDPFVEKTKKL 210 Query: 664 RKN--FDAFFQGLVSFPLYFPGTTFYR-CIQGRKNVQ---KVLKDLLKERLGAPEKRHGD 825 + FD F +V FP P C+ + +++ K + + + RL + +K D Sbjct: 211 LRFDFFDPLFLSVVLFPFLTPIYEMLNICMFPKDSIEFFKKFVYRMKETRLDSVQKHRVD 270 Query: 826 FLDEVVD------ELQSGRGVIDEKFAVDLMAALLFASFATVSSSLTIAMKFLSGHPNVV 987 FL +++ + +S + D + + +FA + SS+L+ + L+ HP+ Sbjct: 271 FLQLMMNAHNDSKDKESHTALSDMEITAQSII-FIFAGYEPTSSTLSFVLHSLATHPDTQ 329 Query: 988 ESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAPGIFRKTLTDVQV 1167 + L+EE + L K+ T++ M + V NE R+ + + R DV++ Sbjct: 330 KKLQEEIDRALPN-----KAPPTYDTVMEMEYLDMVLNETLRLYPIGNRLERVCKKDVEI 384 Query: 1168 KGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGIRLCV 1347 G +P G +VMI A+H +P+ + +P F P R+ E+K S ++PFG G R C+ Sbjct: 385 NGVFMPKGSVVMIPSYALHRDPQHWPEPEEFRPERFSKENKGSIDPYVYLPFGNGPRNCI 444 Query: 1348 GAEFSRIQIALFLHTLVTKYRWKEIKGGEV 1437 G F+ + + L L ++ + ++ K ++ Sbjct: 445 GMRFALMNMKLALTKVLQNFSFQPCKETQI 474
>P15392:CP2A4_MOUSE Cytochrome P450 2A4 - Mus musculus (Mouse)| Length = 494 Score = 94.7 bits (234), Expect = 1e-18 Identities = 109/488 (22%), Positives = 196/488 (40%), Gaps = 43/488 (8%) Frame = +1 Query: 160 TGRLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLK---RYGPVFKTSLVGQPVVVSM 330 +G+LPPG LP VG Q L+ Y +K RYGPVF L + +VV Sbjct: 30 SGKLPPGPTPLPFVGNFLQ-------LNTEQMYNSLMKISQRYGPVFTIYLGSRRIVVLC 82 Query: 331 DAEVNRFIFQQEGKLFRSWYPDTANNIFGKESIASYDGSFHKYVRSFAS-------RLFG 489 E + D A G+ A++D F Y +F+S R F Sbjct: 83 GQEA-----------VKEALVDQAEEFSGRGEQATFDWLFKGYGIAFSSGERAKQLRSFS 131 Query: 490 LDSLRDVLLAEMDCN---------VTDSLAAWAA---EPAIEVKDAVANMVFDLTAKKLI 633 + +LRD + + + DS +P + V+N++ + Sbjct: 132 IATLRDFGVGKRGIEERIQEEAGFLIDSFRKTNGAFIDPTFYLSRTVSNVISSIVFGDRF 191 Query: 634 GFSPEKSRKLRK------NFDAFFQGLV-----SFPLYFPGTT--FYRCIQGRKN--VQK 768 + ++ L + F A G V S + PG ++ +QG ++ +K Sbjct: 192 DYEDKEFLSLLRMMLGSLQFTATSMGQVYEMFSSVMKHLPGPQQQAFKELQGLEDFITKK 251 Query: 769 VLKDLLKERLGAPEKRHGDFLDEVVDELQSGRGVIDEKFAVDLMAALLFASFATVSSSLT 948 V + +P FL +++E ++ K V L FA TVS++L Sbjct: 252 VEHNQRTLDPNSPRDFIDSFLIRMLEEKKNPNTEFYMKNLVLTTLNLFFAGTETVSTTLR 311 Query: 949 IAMKFLSGHPNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVA 1128 L +P++ + EE + ++ + + +E+ M +T V +EI R +++ Sbjct: 312 YGFLLLMKYPDIEAKVHEEIDRVIGRNRQPK-----YEDRMKMPYTEAVIHEIQRFADLI 366 Query: 1129 P-GIFRKTLTDVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTML 1305 P G+ R+ D + + + +P G V +V +P+ F +P FNP + D+ + Sbjct: 367 PMGLARRVTKDTKFRDFLLPKGTEVFPMLGSVLKDPKFFSNPKDFNPKHFLDDKGQFKKS 426 Query: 1306 KNFMPFGGGIRLCVGAEFSRIQIALFLHTLVTKYRWKEIKGGEVQRISE-----IVFPEG 1470 F+PF G R C G +R+++ LFL ++ + +K + + +S + P Sbjct: 427 DAFVPFSIGKRYCFGEGLARMELFLFLTNIMQNFHFKSTQAPQDIDVSPRLVGFVTIPPT 486 Query: 1471 YHIQIIPR 1494 Y + + R Sbjct: 487 YTMSFLSR 494
>Q8AXY5:C356_FUNHE Cytochrome P450 3A56 - Fundulus heteroclitus (Killifish) (Mummichog)| Length = 496 Score = 94.7 bits (234), Expect = 1e-18 Identities = 101/420 (24%), Positives = 180/420 (42%), Gaps = 25/420 (5%) Frame = +1 Query: 253 FYKQRLKRYGPVFKTSLVGQPVVVSMDAEVNRFIFQQEGKLFRSWYPDTANNIFGKESIA 432 F ++ K+YG V+ QPV+ D E+ + + +E F + + N ++++ Sbjct: 59 FDEECKKKYGKVWGIYDGRQPVLCVTDPEIIKAVLVKECLSFFTNRRNFHLNGPLYDALS 118 Query: 433 SYDGSFHKYVRSFASRLFGLDSLRDV--LLAEMDCNVTDSLAAWA-AEPAIEVK------ 585 + K +RS S F L+++ ++ N+ S+ A + +++K Sbjct: 119 VAEDDQWKRIRSVLSPSFTSGRLKEMFEIMKNHSANLIRSMKKKADKDEPLDLKEFFGSY 178 Query: 586 --DAVANMVFDLTAKKLIGFSPEKSRKLRK--NFD---AFFQGLVSFPLYFPGTTFYRCI 744 D V + F + L S ++K FD F + FP P + Sbjct: 179 SMDVVTSTAFSVDIDSLNNPSDPFVTNIKKMLKFDFLNPLFLAVAFFPFLGPILEKFELS 238 Query: 745 QGRKNVQKV----LKDLLKERLGAPEKRHGDFLDEVVDELQSGRGVIDEKFAVD-----L 897 K+V L+ + R + +K DFL ++D Q G +K D Sbjct: 239 FFPKSVTDFFYASLEKIKSNREASQQKSRVDFLQLMIDS-QKNSGAQQDKSLTDHEILSQ 297 Query: 898 MAALLFASFATVSSSLTIAMKFLSGHPNVVESLKEEHEAILKKREEGAKSGITWEEYKSM 1077 +FA + T SSSLT L+ +P V++ L+EE +A K+ + ++ M Sbjct: 298 SMIFIFAGYETSSSSLTFLAYNLATNPEVMKKLQEEIDATFPN-----KAPVHYQPLMEM 352 Query: 1078 TFTAQVTNEISRVSNVAPGIFRKTLTDVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLT 1257 + V NE R+ +A + R V++ G IP +VMI +H +PE++ +P Sbjct: 353 EYLDCVINESLRLFPIAARLERVAKAAVEINGIVIPKDMVVMIPTWPLHRDPEIWPEPEA 412 Query: 1258 FNPWRWQDESKKSTMLKNFMPFGGGIRLCVGAEFSRIQIALFLHTLVTKYRWKEIKGGEV 1437 F P R+ ++K + +MPFG G R C+G F+ + I L + ++ +Y + K EV Sbjct: 413 FKPERFSKKNKDNIDPYIYMPFGSGPRNCIGMRFALVLIKLAVVEILQQYSFSVCKETEV 472
>P24460:CP2BB_CANFA Cytochrome P450 2B11 - Canis familiaris (Dog)| Length = 494 Score = 94.4 bits (233), Expect = 1e-18 Identities = 116/491 (23%), Positives = 188/491 (38%), Gaps = 45/491 (9%) Frame = +1 Query: 163 GRLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLK---RYGPVFKTSLVGQPVVVSMD 333 G LPPG LP++G Q +D K L+ +YG VF L + V+ Sbjct: 28 GHLPPGPRPLPILGNFLQ-------MDRKGLLKSFLRLQEKYGDVFTVYLGPRRTVMLCG 80 Query: 334 AEVNRFIFQQEGKLFRSWYPDTANNIFGKESIASYDGSFHKYVRSFAS-------RLFGL 492 + R D A G+ IA + F Y FA+ R F L Sbjct: 81 IDA-----------IREALVDNAEAFSGRGKIAVVEPVFQGYGVVFANGERWKTLRRFSL 129 Query: 493 DSLRDV----------LLAEMDCNVTD--SLAAWAAEPAIEVKDAVANMVFDLTAKKLIG 636 ++RD + E C V + +P AN++ + K G Sbjct: 130 ATMRDFGMGKRSVEERIQEEAQCLVEELRKTEGVLQDPTFFFHSMTANIICSIVFGKRFG 189 Query: 637 FS-PEKSRKLRKNFDAF----------FQGLVSFPLYFPGT--TFYRCIQGRKNVQKVLK 777 + PE R + + +F F+ SF YFPGT Y +Q K + Sbjct: 190 YKDPEFLRLMNLFYVSFALISSFSSQMFELFHSFLKYFPGTHRQVYNNLQEIKAFIARMV 249 Query: 778 DLLKERLGAPEKRHGDFLDEVVDELQSGRGVIDEKF----AVDLMAALLFASFATVSSSL 945 + +E L R DF+D + + + +F +D +L FA T S++L Sbjct: 250 EKHRETLDPSAPR--DFIDAYLIRMDKEKAEPSSEFHHRNLIDTALSLFFAGTETTSTTL 307 Query: 946 TIAMKFLSGHPNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNV 1125 + +P++ E + +E + ++ G + ++ M +T V +EI R ++ Sbjct: 308 RYGFLLMLKYPHIAERIYKEIDQVI-----GPHRLPSLDDRAKMPYTDAVIHEIQRFGDL 362 Query: 1126 AP-GIFRKTLTDVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTM 1302 P G+ D+ +GY IP G V + +P FE P FNP + D + Sbjct: 363 LPIGVPHMVTKDICFRGYIIPKGTEVFPILHSALNDPHYFEKPDVFNPDHFLDANGALKK 422 Query: 1303 LKNFMPFGGGIRLCVGAEFSRIQIALFLHTLVTKYRWKEIKGGE-----VQRISEIVFPE 1467 + F+PF G R+C+G +R+++ LF T++ + E Q I P Sbjct: 423 NEAFIPFSIGKRICLGEGIARMELFLFFTTILQNFSVASPMAPEDIDLTPQEIGVGKLPP 482 Query: 1468 GYHIQIIPREG 1500 Y I + R G Sbjct: 483 VYQISFLSRGG 493
>P49264:C71B1_THLAR Cytochrome P450 71B1 - Thlaspi arvense (Field penny-cress)| Length = 496 Score = 94.4 bits (233), Expect = 1e-18 Identities = 108/456 (23%), Positives = 189/456 (41%), Gaps = 29/456 (6%) Frame = +1 Query: 169 LPPGSMGLPLVGETFQFF-KPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEVN 345 LPPG LP++G Q KP ++ + K YGP+ L VV+ E Sbjct: 29 LPPGPPRLPIIGNLHQLGEKPHRAM------VELSKTYGPLMSLKLGSVTTVVATSVETV 82 Query: 346 RFIFQQEGKLFRS----WYPDTANNIFGKESIASYDGSFHKYVRSFASRLFG---LDSLR 504 R + + S YP + YD + + + L+ + S R Sbjct: 83 RDVLKTYDLECCSRPYMTYPARITYNLKDLVFSPYDKYWRQVRKLTVVELYTAKRVQSFR 142 Query: 505 DVLLAEMDCNVTDSLAAWAAEPAIEVKDAVANMVFDLTAKKLIGFSPEKSRKLRKNFDAF 684 + E+ V + A ++E + + + M + + G + E S KL + Sbjct: 143 HIREEEVASFVRFNKQAASSEETVNLSQKILKMSGSVICRIGFGINLEGS-KLENTYQEI 201 Query: 685 ----FQGLVSFPL--YFP--GTTFYRCIQGRKNVQKVLKDLLKERLGAPEKRHGD---FL 831 F+ L S YFP GT R +KV + +RH D Sbjct: 202 IVQAFEVLGSLAAVDYFPVIGTIIDRITGLHAKCEKVFHGI-DSFFDQAIQRHIDDPSIK 260 Query: 832 DEVVD---ELQSGRGVIDE-----KFAVDLMAALLFASFATVSSSLTIAMKFLSGHPNVV 987 D+++D +++ G G + E + ++ +L A T + ++T AM L +P V+ Sbjct: 261 DDIIDLLLKMERGEGSLGEYELTREHTKGILMNILTAGIDTSAQTMTWAMTHLLANPRVM 320 Query: 988 ESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAPGIF-RKTLTDVQ 1164 + L+ E +K +E IT ++ + + + V E R+S + P + R D++ Sbjct: 321 KKLQAEIREKIKNIDE-----ITDDDVEQLDYFKLVLKETFRISPIVPVLVPRVAAKDLK 375 Query: 1165 VKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLK-NFMPFGGGIRL 1341 + GY +P + ++ AVH++P +++DP TFNP R+ D L +PFG G R+ Sbjct: 376 IAGYDVPEKTWIHVNMWAVHMSPSIWKDPETFNPERFIDNQTDFKGLNFELLPFGSGRRM 435 Query: 1342 CVGAEFSRIQIALFLHTLVTKYRWKEIKGGEVQRIS 1449 C G + L L L+ ++ WK G + + +S Sbjct: 436 CPGMGMGLAVVHLTLINLLYRFDWKLPNGMKAEELS 471
>Q29510:CP2CU_RABIT Cytochrome P450 2C30 - Oryctolagus cuniculus (Rabbit)| Length = 489 Score = 94.0 bits (232), Expect = 2e-18 Identities = 100/444 (22%), Positives = 183/444 (41%), Gaps = 25/444 (5%) Frame = +1 Query: 166 RLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEVN 345 +LPPG PLVG Q + + S + K+ YGPVF +P VV E Sbjct: 28 KLPPGPTAFPLVGNVLQLDRKNISKSISMLAKE----YGPVFTVYFGTKPSVVLHGYEAV 83 Query: 346 RFIFQQEGKLF--RSWYPDTANNIFGKESIASYDGSFHKYVRSFASRLF-----GLDSLR 504 + G+ F R P G AS G K R F + G ++ Sbjct: 84 KEALVDHGEEFSGRVTVPVFDRYAQGAGLFAS-QGELWKETRRFTLTVLRNMGMGKKTIE 142 Query: 505 DVLLAEMDCNVT--DSLAAWAAEPAIEVKDAVANMVFDLTAKKLIGFSPEKSRKLRKNF- 675 D + E C V A +P+ + N++ + + ++ + + L K+F Sbjct: 143 DRIQEEASCLVKALKETNASPCDPSSLLFCVPCNVICSIIFQNRFEYNDQTFQTLVKHFL 202 Query: 676 -------DAFFQGLVSFPL--YFPGTTFYRCIQGRKNVQKVLKDLLKERLGAPEKRHG-D 825 + Q +FP+ Y PG+ + + + K + ++E + + + D Sbjct: 203 DSIRLFNTPWMQLYNTFPILHYLPGS-HHELFKVFNDQMKFFSEKIREHQESLDHNNPRD 261 Query: 826 FLDEVVDELQSGRGVIDEKFAVDLMAALLFASF----ATVSSSLTIAMKFLSGHPNVVES 993 F+D ++ +++ + +F + + ++ F T SS++ + L HP + Sbjct: 262 FIDYLLIKMEKEKHNKQSQFTMHHLLVTIWDVFDAGSQTTSSTMQFGLLLLMKHPEIAAK 321 Query: 994 LKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAPGIFRKTLT-DVQVK 1170 ++EE E ++ G ++ M +T V +EI R ++ P +T D+Q + Sbjct: 322 VQEEIERVI-----GRDRSPCMQDRSCMPYTDAVIHEIQRYIDMVPNNVPHAVTQDIQFR 376 Query: 1171 GYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGIRLCVG 1350 GY IP G ++ S +V + + F +P F+P + D S F+PF G R C G Sbjct: 377 GYLIPKGTHILPSLTSVLYDEKEFPNPEKFDPGHFLDASGNFKKSDYFLPFSIGKRACAG 436 Query: 1351 AEFSRIQIALFLHTLVTKYRWKEI 1422 +R+++ L L T++ + K + Sbjct: 437 EGLARMELFLVLTTILQHFTLKPL 460
>Q6JZS3:CP1A1_ORYLA Cytochrome P450 1A1 - Oryzias latipes (Medaka fish) (Japanese| ricefish) Length = 521 Score = 94.0 bits (232), Expect = 2e-18 Identities = 121/489 (24%), Positives = 205/489 (41%), Gaps = 43/489 (8%) Frame = +1 Query: 91 GLAAVVAGWLAHCVYKWTNPACSTG-RLPPGSMGLPLVGETFQF-FKPSPSLDVPAFYKQ 264 GL A+ + + + K N G R PG LP++G + KP SL + Sbjct: 17 GLIALTTVCVVYLLLKHFNKEIPGGLRQLPGPTPLPIIGNLLKLGSKPYLSLT------E 70 Query: 265 RLKRYGPVFKTSLVGQPVVVSMDAEVNRFIFQQEGKLFRSWYPDTANNIF---GKESIAS 435 KR+G VF+ + +PVVV E R ++G F S PD + F GK S Sbjct: 71 MSKRFGDVFQIQIGMRPVVVLSGNETVRQALIKQGDDF-SGRPDLYSFQFINDGKSLAFS 129 Query: 436 YDGS---------FHKYVRSFASRLFGLDSLRDVLLAEMDCNVTDSLAAWAA-------- 564 D + + +RSF+S L G ++ +L E C T+ L Sbjct: 130 TDQAGVWRARRKLAYSALRSFSS-LEGSNAEYSCMLEEHICKETEHLVKEIEKVMKTEGK 188 Query: 565 -EPAIEVKDAVANMV--------FDLTAKKLIGFSPEKSRKLRKNFDAFFQGLVSFPLYF 717 +P + +VAN++ +D ++L+G ++ + Y Sbjct: 189 FDPYRYIVVSVANVICGMCFGRRYDHHDQELVGLVNLSEDFVQVTGSGNPADFIPALRYL 248 Query: 718 PGTTFYRCIQGRKNVQKVLKDLLKERLGAPEKRH-GDFLDEVVDELQ-------SGRGVI 873 P + ++ Q ++ ++ E +K + D D ++D + S + Sbjct: 249 PSKAMKKFVEINNRFQSFVQKIVNEHSATYDKDNIRDITDSLIDHCEDRKLDENSNIQMS 308 Query: 874 DEKFAVDLMAALLFASFATVSSSLTIAMKFLSGHPNVVESLKEEHEAILKKREEGAKSGI 1053 DEK V ++ L A F T+S++L+ A+ +L +P++ + L EE K G Sbjct: 309 DEK-VVGIVNDLFGAGFDTISTALSWAVGYLVAYPDIEKGLFEEI-----KENIGLNRNP 362 Query: 1054 TWEEYKSMTFTAQVTNEISRVSNVAP-GIFRKTLTDVQVKGYTIPAGWLVMISPMAVHLN 1230 T + ++ T EI R S+ P I T D + GY IP V I+ ++ + Sbjct: 363 TISDRSNLPLTDAFILEIFRHSSFLPFTIPHCTTRDTSLNGYYIPKDTCVFINQWQINHD 422 Query: 1231 PELFEDPLTFNPWRWQDESKKSTML---KNFMPFGGGIRLCVGAEFSRIQIALFLHTLVT 1401 P+L++DP +FNP R+ E + M FG G R C+G +R ++ LFL ++ Sbjct: 423 PKLWQDPSSFNPDRFLSEDGSEVNRLDGEKVMVFGLGKRRCIGEVIARNEVFLFLAIMIQ 482 Query: 1402 KYRWKEIKG 1428 K ++E+ G Sbjct: 483 KLCFEEMPG 491
>P05180:CP2H1_CHICK Cytochrome P450 2H1 - Gallus gallus (Chicken)| Length = 491 Score = 93.6 bits (231), Expect = 2e-18 Identities = 106/480 (22%), Positives = 198/480 (41%), Gaps = 36/480 (7%) Frame = +1 Query: 163 GRLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEV 342 G+ PPG +P++G FQ D+ +K+ K+YGP+F L + +VV ++ Sbjct: 30 GKEPPGPTPIPIIGNVFQL----NPWDLMGSFKELSKKYGPIFTIHLGPKKIVVLYGYDI 85 Query: 343 NRFIFQQEGKLF--RSWYPDTANNIFGKESIASYDGSFHKYVRSFASRLFGLDSLRDVLL 516 + G+ F R P +F I + +G + +R FA L +LRD + Sbjct: 86 VKEALIDNGEAFSGRGILP-LIEKLFKGTGIVTSNGETWRQLRRFA-----LTTLRDFGM 139 Query: 517 AEMDCN---------VTDSLAAWAAEPAIEVK---DAVANMVFDLTAKKLIGFSPEKSRK 660 + + + + EP K AVAN++ + + +K Sbjct: 140 GKKGIEERIQEEAHFLVERIRKTHEEPFNPGKFLIHAVANIICSIVFGDRFDYEDKKFLD 199 Query: 661 LRKNFDAF--FQGLVSFPLYFPGTTFYRCIQGR-----KNVQKVLKDLLKERLGAPEKRH 819 L + + +Q + LY T + G KN + V D +KE + A ++ Sbjct: 200 LIEMLEENNKYQNRIQTLLYNFFPTILDSLPGPHKTLIKNTETV-DDFIKEIVIAHQESF 258 Query: 820 G-----DFLDEVVDELQSGRGVIDEKFAVDLMAA----LLFASFATVSSSLTIAMKFLSG 972 DF+D +++++ + + F V+ + L A T S++L + L Sbjct: 259 DASCPRDFIDAFINKMEQEKE--NSYFTVESLTRTTLDLFLAGTGTTSTTLRYGLLILLK 316 Query: 973 HPNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAP-GIFRKT 1149 HP + E + +E + ++ G + + +T V +EI R + P + Sbjct: 317 HPEIEEKMHKEIDRVV-----GRDRSPCMADRSQLPYTDAVIHEIQRFIDFLPLNVPHAV 371 Query: 1150 LTDVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGG 1329 + D +++ Y IP ++ + + + F +P F+P + + + FMPF Sbjct: 372 IKDTKLRDYFIPKDTMIFPLLSPILQDCKEFPNPEKFDPGHFLNANGTFRRSDYFMPFSA 431 Query: 1330 GIRLCVGAEFSRIQIALFLHTLVTKYRWKEIKGGEVQRISEIV-----FPEGYHIQIIPR 1494 G R+C G +R++I LFL +++ + K +K + IS I+ P Y + IPR Sbjct: 432 GKRICAGEGLARMEIFLFLTSILQNFSLKPVKDRKDIDISPIITSLANMPRPYEVSFIPR 491
>P05182:CP2E1_RAT Cytochrome P450 2E1 - Rattus norvegicus (Rat)| Length = 493 Score = 93.6 bits (231), Expect = 2e-18 Identities = 108/473 (22%), Positives = 196/473 (41%), Gaps = 31/473 (6%) Frame = +1 Query: 169 LPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEVNR 348 LPPG LP++G FQ D+P + + KR+GPVF L + +VV + + Sbjct: 32 LPPGPFPLPILGNIFQL----DLKDIPKSFTKLAKRFGPVFTLHLGSRRIVVLHGYKAVK 87 Query: 349 FIFQQEGKLFRSWYPDTANNIFGKESIASYDGSFHKYVRSFA---SRLFGL----DSLRD 507 + F + + I +G K VR F+ R +G+ + R Sbjct: 88 EVLLNHKNEFSGRGDIPVFQEYKNKGIIFNNGPTWKDVRRFSLSILRDWGMGKQGNEARI 147 Query: 508 VLLAEMDCNVTDSLAAWAAEPAIEVKDAVANMVFDLTAKKLIGFSPEKSRKLRKNFDAFF 687 A+ +P + A N++ D+ K ++ +K +L F+ F Sbjct: 148 QREAQFLVEELKKTKGQPFDPTFLIGCAPCNVIADILFNKRFDYNDKKCLRLMSLFNENF 207 Query: 688 QGLVSFP---LYFPGTTFYRCIQGRKNVQKVLKDL--LKERLGAPEKRHGDFLD-----E 837 L+S P LY + R + G + +K++K++ +K+ K H LD + Sbjct: 208 Y-LLSTPWIQLYNNFADYLRYLPG--SHRKIMKNVSEIKQYTLEKAKEHLQSLDINCARD 264 Query: 838 VVD----ELQSGRGVIDEKFAVD----LMAALLFASFATVSSSLTIAMKFLSGHPNVVES 993 V D E++ + + + ++ +A L FA T S++L + L +P + E Sbjct: 265 VTDCLLIEMEKEKHSQEPMYTMENVSVTLADLFFAGTETTSTTLRYGLLILMKYPEIEEK 324 Query: 994 LKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAP-GIFRKTLTDVQVK 1170 L EE + ++ G + M + V +EI R N+ P + + D + Sbjct: 325 LHEEIDRVI-----GPSRVPAVRDRLDMPYMDAVVHEIQRFINLVPSNLPHEATRDTVFQ 379 Query: 1171 GYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGIRLCVG 1350 GY IP G +V+ + ++ + F DP F P + +E+ K F F G R+CVG Sbjct: 380 GYVIPKGTVVIPTLDSLLYDSHEFPDPEKFKPEHFLNENGKFKYSDYFKAFSAGKRVCVG 439 Query: 1351 AEFSRIQIALFLHTLVTKYRWKEIKGGEVQRISEIV-----FPEGYHIQIIPR 1494 +R+++ L L ++ + K + + +S + P + + +IPR Sbjct: 440 EGLARMELFLLLSAILQHFNLKSLVDPKDIDLSPVTVGFGSIPPQFKLCVIPR 492
>O55071:CP2BJ_MOUSE Cytochrome P450 2B19 - Mus musculus (Mouse)| Length = 492 Score = 93.6 bits (231), Expect = 2e-18 Identities = 116/478 (24%), Positives = 198/478 (41%), Gaps = 40/478 (8%) Frame = +1 Query: 94 LAAVVAGWLAHCVYKWTNPACSTGRLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLK 273 L A+ G+L V + + + G PPG LP +G Q + + + + Q + Sbjct: 8 LLALTTGFLIFLVSQ--SQPKTHGHFPPGPRPLPFLGNLLQMDRRG----LLSSFIQLQE 61 Query: 274 RYGPVFKTSLVGQPVVVSMDAEVNRFIFQQEGKLFRSWYPDTANNIFGKESIASYDGSFH 453 +YG VF L +PVV+ + R + + F G+ ++A D Sbjct: 62 KYGDVFTVHLGPRPVVMLCGTDTIREALVNQAEAFS-----------GRGTVAVLDPIVQ 110 Query: 454 KYVRSFAS-------RLFGLDSLRDV----------LLAEMDCNVTDSLAAWAA--EPAI 576 Y F+S R F L ++RD + E C V + A P Sbjct: 111 GYGVIFSSGERWKTLRRFSLATMRDFGMGKRSVEERIKEEAQCLVEELKKYKGAPLNPTF 170 Query: 577 EVKDAVANMVFDLTAKKLIGFSPEKSRKLRKNFDAFFQGLVS-----FPL------YFPG 723 + VAN++ + + + + L F + S F L YFPG Sbjct: 171 YFQCIVANIICSIVFGERFDYKDHQFLHLLNLIYQTFSLMSSLSSQVFELFSAILKYFPG 230 Query: 724 TTFYRCIQGRKNVQKVL----KDLLKERLGAPEKRHGDFLDEVVDELQSGRGVIDEKF-- 885 +R I KN+Q++L + K R DF+D + ++ + +F Sbjct: 231 A--HRQIS--KNLQEILDYIGHSVEKHRATLDPSAPRDFIDTYLLRMEKEKSNHHTEFHH 286 Query: 886 --AVDLMAALLFASFATVSSSLTIAMKFLSGHPNVVESLKEEHEAILKKREEGAKSGITW 1059 V + +L FA T S++L + + +P+V E +++E + ++ G+ T Sbjct: 287 QNLVISVLSLFFAGTETTSTTLRYSFLIMLKYPHVAEKVQKEIDQVI-----GSHRLPTL 341 Query: 1060 EEYKSMTFTAQVTNEISRVSNVAP-GIFRKTLTDVQVKGYTIPAGWLVM-ISPMAVHLNP 1233 ++ M +T V +EI R +++AP G+ K D +GY IP V I A+H +P Sbjct: 342 DDRTKMPYTDAVIHEIQRFTDLAPIGLPHKVTKDTLFRGYLIPKNTEVYPILSSALH-DP 400 Query: 1234 ELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGIRLCVGAEFSRIQIALFLHTLVTKY 1407 FE P +FNP + D + + FMPF G R+C+G +R ++ LF T++ + Sbjct: 401 RYFEQPDSFNPEHFLDANGALKTNEAFMPFSTGKRICLGEGIARNELFLFFTTILQNF 458
>Q16696:CP2AD_HUMAN Cytochrome P450 2A13 - Homo sapiens (Human)| Length = 494 Score = 93.6 bits (231), Expect = 2e-18 Identities = 109/496 (21%), Positives = 196/496 (39%), Gaps = 50/496 (10%) Frame = +1 Query: 157 STGRLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLK---RYGPVFKTSLVGQPVVVS 327 S G+LPPG LP +G Q L+ Y +K RYGPVF L + VVV Sbjct: 29 SRGKLPPGPTPLPFIGNYLQ-------LNTEQMYNSLMKISERYGPVFTIHLGPRRVVVL 81 Query: 328 MDAEVNRFIFQQEGKLFRSWYPDTANNIFGKESIASYDGSFHKYVRSFAS-------RLF 486 + + D A G+ A++D F Y +F++ R F Sbjct: 82 CGHDA-----------VKEALVDQAEEFSGRGEQATFDWLFKGYGVAFSNGERAKQLRRF 130 Query: 487 GLDSLR---------DVLLAEMDCNVTDSLAAWAA---EPAIEVKDAVANMV-------- 606 + +LR + + E + D+L +P + V+N++ Sbjct: 131 SIATLRGFGVGKRGIEERIQEEAGFLIDALRGTHGANIDPTFFLSRTVSNVISSIVFGDR 190 Query: 607 FDLTAKKLIG----------FSPEKSRKLRKNFDAFFQGLVSFPLYFPGTTFYRCIQGRK 756 FD K+ + F+ + +L + F + + L P ++ +QG + Sbjct: 191 FDYEDKEFLSLLRMMLGSFQFTATSTGQLYEMFSSVMKHLPG-----PQQQAFKELQGLE 245 Query: 757 NVQKVLKDLLKERLGAPEKRHGDFLDEVVDELQSGRGVIDEKFAVDLMAA----LLFASF 924 + + K + + DF+D + +Q + +F + + L FA Sbjct: 246 DF--IAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFFAGT 303 Query: 925 ATVSSSLTIAMKFLSGHPNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNE 1104 TVS++L L HP V + EE + ++ K + +E+ M +T V +E Sbjct: 304 ETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPK-----FEDRAKMPYTEAVIHE 358 Query: 1105 ISRVSNVAP-GIFRKTLTDVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQD 1281 I R ++ P G+ + D + + + +P G V +V +P F +P FNP + D Sbjct: 359 IQRFGDMLPMGLAHRVNKDTKFRDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFNPQHFLD 418 Query: 1282 ESKKSTMLKNFMPFGGGIRLCVGAEFSRIQIALFLHTLVTKYRWKEIKGGE-----VQRI 1446 + + F+PF G R C G +R+++ LF T++ +R+K + + + + Sbjct: 419 KKGQFKKSDAFVPFSIGKRYCFGEGLARMELFLFFTTIMQNFRFKSPQSPKDIDVSPKHV 478 Query: 1447 SEIVFPEGYHIQIIPR 1494 P Y + +PR Sbjct: 479 GFATIPRNYTMSFLPR 494
>P20852:CP2A5_MOUSE Cytochrome P450 2A5 - Mus musculus (Mouse)| Length = 494 Score = 93.6 bits (231), Expect = 2e-18 Identities = 105/462 (22%), Positives = 186/462 (40%), Gaps = 43/462 (9%) Frame = +1 Query: 160 TGRLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLK---RYGPVFKTSLVGQPVVVSM 330 +G+LPPG LP +G Q L+ Y +K RYGPVF L + +VV Sbjct: 30 SGKLPPGPTPLPFIGNFLQ-------LNTEQMYNSLMKISQRYGPVFTIYLGPRRIVVLC 82 Query: 331 DAEVNRFIFQQEGKLFRSWYPDTANNIFGKESIASYDGSFHKYVRSFAS-------RLFG 489 E + D A G+ A++D F Y F+S R F Sbjct: 83 GQEA-----------VKEALVDQAEEFSGRGEQATFDWLFKGYGVVFSSGERAKQLRRFS 131 Query: 490 LDSLRDVLLAEMDCN---------VTDSLAAWAA---EPAIEVKDAVANMV--------F 609 + +LRD + + + DS +P + V+N++ F Sbjct: 132 IATLRDFGVGKRGIEERIQEEAGFLIDSFRKTNGAFIDPTFYLSRTVSNVISSIVFGDRF 191 Query: 610 DLTAKKLIG----------FSPEKSRKLRKNFDAFFQGLVSFPLYFPGTTFYRCIQGRKN 759 D K+ + F+ +L + F + + L P ++ +QG ++ Sbjct: 192 DYEDKEFLSLLRMMLGSFQFTATSMGQLYEMFSSVMKHLPG-----PQQQAFKELQGLED 246 Query: 760 --VQKVLKDLLKERLGAPEKRHGDFLDEVVDELQSGRGVIDEKFAVDLMAALLFASFATV 933 +KV + +P FL +++E ++ K V L FA TV Sbjct: 247 FITKKVEHNQRTLDPNSPRDFIDSFLIRMLEEKKNPNTEFYMKNLVLTTLNLFFAGTETV 306 Query: 934 SSSLTIAMKFLSGHPNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISR 1113 S++L L HP++ + EE + ++ + + +E+ M +T V +EI R Sbjct: 307 STTLRYGFLLLMKHPDIEAKVHEEIDRVIGRNRQPK-----YEDRMKMPYTEAVIHEIQR 361 Query: 1114 VSNVAP-GIFRKTLTDVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESK 1290 +++ P G+ R+ D + + + +P G V +V +P+ F +P FNP + D+ Sbjct: 362 FADMIPMGLARRVTKDTKFRDFLLPKGTEVFPMLGSVLKDPKFFSNPKDFNPKHFLDDKG 421 Query: 1291 KSTMLKNFMPFGGGIRLCVGAEFSRIQIALFLHTLVTKYRWK 1416 + F+PF G R C G +R+++ LFL ++ + +K Sbjct: 422 QFKKNDAFVPFSIGKRYCFGEGLARMELFLFLTNIMQNFHFK 463
>Q91W64:CP270_MOUSE Cytochrome P450 2C70 - Mus musculus (Mouse)| Length = 489 Score = 93.6 bits (231), Expect = 2e-18 Identities = 105/451 (23%), Positives = 184/451 (40%), Gaps = 31/451 (6%) Frame = +1 Query: 163 GRLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQR---LKRYGPVFKTSLVGQPVVVSMD 333 G+LPPG LP+VG Q +DV K K+YGPVF L +P VV Sbjct: 27 GKLPPGPTPLPIVGNILQ-------VDVKNISKSMGMLAKKYGPVFTVYLGMKPTVVLHG 79 Query: 334 AEVNRFIFQQEGKLFRSWYPDTANNIFGKES----IASYDGSFHKYVRSFAS---RLFGL 492 + + +G F T +++ + S I +G K R F+ R G+ Sbjct: 80 YKAMKEALIDQGDEFSD---KTDSSLLSRTSQGLGIVFSNGETWKQTRRFSLMVLRSMGM 136 Query: 493 ------DSLRDVLLAEMDC------NVTDSLAAWAAEPAIEVKDAVANMVFDLTAKKLIG 636 D +++ +L +D + D A P + + FD + Sbjct: 137 GKKTIEDRIQEEILYMLDALRKTNGSPCDPSFLLACVPCNVISTVIFQHRFDYNDQTFQD 196 Query: 637 FSPEKSRKLRKNFDAFFQGLVSFPL--YFPG--TTFYRCIQGRKNVQKVLKDLLKERLGA 804 F RK+ + Q ++P+ Y PG F + + +K +L+++ + + Sbjct: 197 FMENFHRKIEILASPWSQLCSAYPILYYLPGIHNRFLKDVTQQKKF--ILEEINRHQKSL 254 Query: 805 PEKRHGDFLDEVVDELQSGRGVIDEKFAVDLMAA----LLFASFATVSSSLTIAMKFLSG 972 DF+D + +++ + +F +D + L A T SS++ + L Sbjct: 255 DLSNPQDFIDYFLIKMEKEKHNQKSEFTMDNLVVSIGDLFGAGTETTSSTVKYGLLLLLK 314 Query: 973 HPNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAP-GIFRKT 1149 +P V ++EE ++ + T ++ M +T V +EI R + P RKT Sbjct: 315 YPEVTAKIQEEIAHVIGRHRRP-----TMQDRNHMPYTDAVLHEIQRYIDFVPIPSPRKT 369 Query: 1150 LTDVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGG 1329 DV+ +GY IP G VM +V + + F +P F+P + DE F+ F Sbjct: 370 TQDVEFRGYHIPKGTSVMACLTSVLNDDKEFPNPEKFDPGHFLDEKGNFKKSDYFVAFSA 429 Query: 1330 GIRLCVGAEFSRIQIALFLHTLVTKYRWKEI 1422 G R C+G +R+++ L L ++ + K + Sbjct: 430 GRRACIGEGLARMEMFLILTNILQHFTLKPL 460
>P14263:CP51_CANTR Cytochrome P450 51 - Candida tropicalis (Yeast)| Length = 528 Score = 93.2 bits (230), Expect = 3e-18 Identities = 100/429 (23%), Positives = 178/429 (41%), Gaps = 41/429 (9%) Frame = +1 Query: 253 FYKQRLKRYGPVFKTSLVGQPVVVSMDAEVNRFIFQQE--GKLFRSWYPDTANNIFGKES 426 F K RLK YG VF L+G+ + V + + + FI+ + Y +FGK Sbjct: 72 FEKCRLK-YGDVFSFMLLGKVMTVYLGPKGHEFIYNAKLSDVSAEEAYTHLTTPVFGKGV 130 Query: 427 IASYDGSFHKYVRSFASRLFGLDSLRDVLLAEMDCNVTDSLAAWAAEPAIEVKDAVANMV 606 I S + FA DS + + ++ V + + E VA+++ Sbjct: 131 IYDCPNSRLMEQKKFAKFALTTDSFK-TYVPKIREEVLNYFVNDVSFKTKERDHGVASVM 189 Query: 607 FDLTAKKLIGFSPEK---SRKLRKNFDAFF--------QGLVSFPLYFPGTT----FYRC 741 T ++ F+ + ++RK+FD F +G FP + R Sbjct: 190 --KTQPEITIFTASRCLFGDEMRKSFDRSFAQLYADLDKGFTPINFVFPNLPLPHYWRRD 247 Query: 742 IQGRKNVQKVLKDLLKERLGAPEKRHGDFLDEVV--DELQSGRGVIDEKFAVDLMAALLF 915 RK +K++ + R D +D ++ + G + D++ A L+ L+ Sbjct: 248 AAQRKISAHYMKEIKRRRESGDIDPKRDLIDSLLVNSTYKDGVKMTDQEIANLLIGVLMG 307 Query: 916 ASFATVSSSLTIAMKFLSGHPNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQV 1095 + S+S + L+ P + + L EE +LK++ G + +T+E+ + + Sbjct: 308 GQHTSASTSAWFLLH-LAEQPQLQDDLYEELTNLLKEKG-GDLNDLTYEDLQKLPLVNNT 365 Query: 1096 TNEISRVSNVAPGIFRKTLTDVQVKG--YTIPAGWLVMISPMAVHLNPELFEDPLTFNPW 1269 E R+ IFRK + ++V Y IP G V++S H + FE P FNP Sbjct: 366 IKETLRMHMPLHSIFRKVMNPLRVPNTKYVIPKGHYVLVSAGYAHTSDRWFEHPEHFNPR 425 Query: 1270 RWQ-DESKKSTMLKN-------------------FMPFGGGIRLCVGAEFSRIQIALFLH 1389 RW+ D++K S + N ++PFGGG C+G +F+ +Q+ L Sbjct: 426 RWESDDTKASAVSFNSEDTVDYGFGKISKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILT 485 Query: 1390 TLVTKYRWK 1416 T + ++W+ Sbjct: 486 TYIYNFKWR 494
>Q9WVK8:CP46A_MOUSE Cytochrome P450 46A1 - Mus musculus (Mouse)| Length = 500 Score = 93.2 bits (230), Expect = 3e-18 Identities = 85/404 (21%), Positives = 176/404 (43%), Gaps = 18/404 (4%) Frame = +1 Query: 271 KRYGPVFKTSLVGQP-VVVSMDAEVNRFI----FQQEGKLFRSWYPDTANNIFGKESIAS 435 K+YGPV + ++ + V+V+ V +F+ + ++ K++R+ +FG+ ++ Sbjct: 69 KKYGPVVRVNVFYKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSE 128 Query: 436 YD-GSFHKY--VRSFASRLFGLDSLRDVLLAEMDCNVTDSLAAWAAEPAIEVKDAVANMV 606 D G ++K V A L SL + + + V A + + ++D + Sbjct: 129 CDYGRWYKQRKVMDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTCAT 188 Query: 607 FDLTAKK--------LIGFSPEKSRKLRKNFDAFFQGLVSFPLYFPGTT--FYRCIQGRK 756 D+ AK L+G S+ ++ + + + PG + + Sbjct: 189 IDILAKAAFGMETSMLLGAQKPLSQAVKVMLEGISASRNTLAKFMPGKRKQLREIRESIR 248 Query: 757 NVQKVLKDLLKERLGAPEKRHGDFLDEVVDELQSGRGVIDEKFAVDLMAALLFASFATVS 936 +++V KD ++ R A ++ D + L++ G D++ +D A T + Sbjct: 249 LLRQVGKDWVQRRREALKRGEDMPADILTQILKAEEGAQDDEVLLDNFVTFFIAGHETSA 308 Query: 937 SSLTIAMKFLSGHPNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRV 1116 + L + LS P +V L+ E + ++ G+K + +E+ + + +QV E R+ Sbjct: 309 NHLAFTVMELSRQPEIVARLQAEVDEVV-----GSKRHLDYEDLGRLQYLSQVLKESLRL 363 Query: 1117 SNVAPGIFRKTLTDVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKS 1296 A G FR + + G +P ++ S + FEDPLTFNP R+ + K Sbjct: 364 YPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKP 423 Query: 1297 TMLKNFMPFGGGIRLCVGAEFSRIQIALFLHTLVTKYRWKEIKG 1428 + PF G R C+G +F+++++ + + L+ + ++ + G Sbjct: 424 RF--TYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRIEFRLVPG 465
>P29980:CPXN_ANASP Probable cytochrome P450 110 - Anabaena sp. (strain PCC 7120)| Length = 459 Score = 92.8 bits (229), Expect = 4e-18 Identities = 97/430 (22%), Positives = 188/430 (43%), Gaps = 20/430 (4%) Frame = +1 Query: 241 DVPAFYKQRLKRYGPVFKTSLVG-QPVVVSMDAEVNRFIFQQEGKLFRSWYPDTANNIFG 417 D F K+ K+YG +F L G V+ + + + IF Q+ + A + G Sbjct: 23 DPIGFQKKYSKKYGNIFSMQLAGIGSFVILGEPQALQEIFTQDSRFDVGRGNTLAEPLIG 82 Query: 418 KESIASYDGSFHKYVRSFASRLFGLDSLRDVLLAEMDCNVTDSLAA-WAAEPAIEVKDAV 594 + S+ DG H+ R F + L+ A+ C +T+ +A+ W + A+ Sbjct: 83 RTSLMLMDGDRHRRERKLLMPPFHGERLQ--AYAQQICLITNQIASEWQIGQPFVARSAM 140 Query: 595 ANMVFDLTAKKLIGFSPEKSRKLRKNFDAFFQGLVSFPLYFPGTTFYRCIQG-------- 750 + ++ + + G + + + K + + PL F + +Q Sbjct: 141 QKLSLEVIIQIVFGLADGERYQQIKPLFTDWLNMTDSPLR-SSMLFLKSLQKDWGTWTPW 199 Query: 751 --RKNVQKVLKDLLK----ERLGAPEKRHGDFLDEVVDEL-QSGRGVIDEKFAVDLMAAL 909 K+ Q+ + DLL+ E+ ++ GD L ++ ++G+ + DE+ +L+ + Sbjct: 200 GQMKHKQRSIYDLLQAEIEEKRTKENEQRGDVLSLMMAARDENGQAMTDEELKDELLT-I 258 Query: 910 LFASFATVSSSLTIAMKFLSGHPNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTA 1089 LFA T ++++ A + + NV E L++E + + GA E + + Sbjct: 259 LFAGHETTATTIAWAFYQILKNVNVQEKLQQELDRL------GANPNPM--EIAQLPYLT 310 Query: 1090 QVTNEISRVSNVAPGIF-RKTLTDVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNP 1266 V+ E R+ V P +F R T + + + GY + +M S +H +L+ +P F P Sbjct: 311 AVSQETLRMYPVLPTLFPRITKSSINIAGYQLEPDTTLMASIYLIHYREDLYPNPQQFRP 370 Query: 1267 WRWQDESKKSTMLKNFMPFGGGIRLCVGAEFSRIQIALFLHTLVTKYR--WKEIKGGEVQ 1440 R+ + + ++PFGGG R C+G + ++I L + T+++ Y+ E K VQ Sbjct: 371 ERFIERQYSPS---EYIPFGGGSRRCLGYALALLEIKLVIATVLSNYQLALAEDKPVNVQ 427 Query: 1441 RISEIVFPEG 1470 R + P+G Sbjct: 428 RRGFTLAPDG 437
>P12938:CP2D3_RAT Cytochrome P450 2D3 - Rattus norvegicus (Rat)| Length = 500 Score = 92.8 bits (229), Expect = 4e-18 Identities = 109/459 (23%), Positives = 194/459 (42%), Gaps = 29/459 (6%) Frame = +1 Query: 118 LAHCVYKWTNPACSTGRLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKT 297 L H +WT+ R PPG + P++G Q ++P + RYG VF Sbjct: 25 LMHRRQRWTS------RYPPGPVPWPVLGNLLQV----DLCNMPYSMYKLQNRYGDVFSL 74 Query: 298 SLVGQPVVV--SMDAEVNRFIFQQEGKLFRSWYPDTANNIFGKES----IASYDGSFHKY 459 + +PVVV + A + E R P + +G ++ +A Y + + Sbjct: 75 QMGWKPVVVINGLKAVQELLVTCGEDTADRPEMPIFQHIGYGHKAKGVVLAPYGPEWREQ 134 Query: 460 VRSFASRL----FGLDSLRDVLLAEMD--CNVTDSLAAWAAEPAIEVKDAVANMVFDLTA 621 R S L G SL + E C+ + A +P + AV N++ L Sbjct: 135 RRFSVSTLRNFGVGKKSLEQWVTDEASHLCDALTAEAGRPLDPYTLLNKAVCNVIASLIY 194 Query: 622 KKLIGFSPEKSRKLRK--------NFDAFFQGLVSFP--LYFPGTTFYRCIQGRKNVQKV 771 + + K+ K F + L FP L PG + G+K + Sbjct: 195 ARRFDYGDPDFIKVLKILKESMGEQTGLFPEVLNMFPVLLRIPGLAD-KVFPGQKTFLTM 253 Query: 772 LKDLLKE--RLGAPEKRHGDFLDEVVDELQSGRGVIDEKFA---VDLMAALLF-ASFATV 933 + +L+ E + P++ D D + E++ +G + F + L+ LF A T Sbjct: 254 VDNLVTEHKKTWDPDQPPRDLTDAFLAEIEKAKGNPESSFNDANLRLVVNDLFGAGMVTT 313 Query: 934 SSSLTIAMKFLSGHPNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISR 1113 S +LT A+ + HP+V +++E + ++ G + M FT V +E+ R Sbjct: 314 SITLTWALLLMILHPDVQCRVQQEIDEVI-----GQVRHPEMADQAHMPFTNAVIHEVQR 368 Query: 1114 VSNVAP-GIFRKTLTDVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESK 1290 +++ P + KT D++V+G+ IP G ++ + +V + ++E PL F+P + D Sbjct: 369 FADIVPMNLPHKTSRDIEVQGFLIPKGTTLIPNLSSVLKDETVWEKPLRFHPEHFLDAQG 428 Query: 1291 KSTMLKNFMPFGGGIRLCVGAEFSRIQIALFLHTLVTKY 1407 + FMPF G R C+G +R+++ LF L+ ++ Sbjct: 429 NFVKHEAFMPFSAGRRACLGEPLARMELFLFFTCLLQRF 467
>Q91X77:CY250_MOUSE Cytochrome P450 2C50 - Mus musculus (Mouse)| Length = 490 Score = 92.0 bits (227), Expect = 7e-18 Identities = 110/461 (23%), Positives = 185/461 (40%), Gaps = 41/461 (8%) Frame = +1 Query: 163 GRLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEV 342 G+LPPG LP++G Q D+ + K YGPV+ L +P VV E Sbjct: 27 GKLPPGPTPLPIIGNILQINVK----DICQSFTNLSKVYGPVYTLYLGNKPTVVLHGYEA 82 Query: 343 NRFIFQQEGKLF--RSWYP--DTANNIFGKESIASYDGSFHKYVRSFASRLF-----GLD 495 + G+ F R P D A N G I G+ K R F+ G Sbjct: 83 VKEALVDHGEEFAGRGRLPVFDKATNGMG---IIFSKGNVWKNTRRFSLTTLRNLGMGKR 139 Query: 496 SLRDVLLAEMDCNVTD--SLAAWAAEPAIEVKDAVANMV--------FDLTAKKLIGFSP 645 S+ D + E C V + +P + A N++ FD + + Sbjct: 140 SIEDRVQEEARCLVEELRKTNGSPCDPTFILGCAPCNVICSIIFQDRFDYKDRDFLNLME 199 Query: 646 EKSRKLRKNFDAFFQGLVSFPL---YFPGT-----TFYRCIQGRKNVQKVLKDLLKERLG 801 + + + + Q +FP+ Y PG+ Y CI K+ L E++ Sbjct: 200 KLNEITKIMSTPWLQVCNTFPVLLDYCPGSHNKVFKNYACI----------KNFLLEKI- 248 Query: 802 APEKRHGDFLD-----EVVDELQSGRGVIDEKFAVD--------LMAALLFASFATVSSS 942 K H + LD + +D G D + + + L A T S++ Sbjct: 249 ---KEHEESLDVTIPRDFIDYFLINGGQEDGNYPLKNRLEHLAITVTDLFSAGTETTSTT 305 Query: 943 LTIAMKFLSGHPNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSN 1122 L A+ L +P+V ++EE E ++ K ++ M +T + +E+ R + Sbjct: 306 LRYALLLLLKYPHVTAKVQEEIEHVIGKHRSPCM-----QDRSRMPYTDAMIHEVQRFID 360 Query: 1123 VAPGIFRKTLT-DVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKST 1299 + P +T D++ + Y IP G V+ S +V + + F +P F+P + DE+ K Sbjct: 361 LVPNSLPHEVTCDIKFRNYFIPKGTNVITSLSSVLRDSKEFPNPEKFDPGHFLDENGKFK 420 Query: 1300 MLKNFMPFGGGIRLCVGAEFSRIQIALFLHTLVTKYRWKEI 1422 FMPF G R+C G +R+++ LFL +++ + K + Sbjct: 421 KSDYFMPFSTGKRICAGEGLARMELFLFLTSILQNFNLKPL 461
>Q964T1:CP4CU_BLAGE Cytochrome P450 4c21 - Blattella germanica (German cockroach)| Length = 501 Score = 92.0 bits (227), Expect = 7e-18 Identities = 95/450 (21%), Positives = 184/450 (40%), Gaps = 30/450 (6%) Frame = +1 Query: 175 PGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEVNRFI 354 PG+ LPL+G D + ++ L++Y P+ +P V E+ + Sbjct: 35 PGAPSLPLIGTALPILYRRKE-DRMTWIEEILEKYKPLILWYFGNRPFVNISSPELIEVV 93 Query: 355 FQQEGKLFRSWYPDTANNIFGKESIASYDGSFHKYVRSFASRLFGLDSLRD--VLLAEMD 528 + + +++ D ++ G + S +H++ R + F L + AE Sbjct: 94 LRNTQLIDKAFLYDLFHSWLGTGLLTSSGAKWHQH-RKIITPTFHFSILEGFITIFAEKS 152 Query: 529 CNVTDSLAAWAAEPAIEVKDAVANMVFDLTAKKLIGFS--------PEKSRKLRKNFDAF 684 + L ++ V+N D+ + +G S E + K D Sbjct: 153 EILVRKLQKEVGRGPFFIRQYVSNCALDIICETAMGTSVNAQDEGFSEYVTAINKMTDVL 212 Query: 685 FQGLVSFPLY----FPGTTFY----RCIQGRKN-VQKVLKDLLKERLGAP---------- 807 + + LY F T +Y +C++ V K++++ +ER + Sbjct: 213 SDRMANPLLYPEFIFKLTPYYWTHKKCLKVLNGFVNKIIQERKEERKKSKVTQTSEDADI 272 Query: 808 -EKRHGDFLDEVVDELQSGRGVIDEKFAVDLMAALLFASFATVSSSLTIAMKFLSGHPNV 984 +K+ FLD ++D + + D ++ + +F TVS+++T + L HP + Sbjct: 273 GKKKRVPFLDTLLDASEDDNKLTDTDI-LEEVHTFMFEGHDTVSAAMTWLLFELGHHPEI 331 Query: 985 VESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAPGIFRKTLTDVQ 1164 E +E + I +G+ T + +M + +V E R+ R+ D + Sbjct: 332 QEEAYKEVQDIF----QGSDRVPTMADLNNMNYLERVIKESLRLHPSVIYFVREAHQDFE 387 Query: 1165 VKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGIRLC 1344 + GYTIPAG + S +H NPE+F +P FNP + + + ++PF G R C Sbjct: 388 LGGYTIPAGTNIDFSVPFIHRNPEIFPNPRCFNPDNFLPDRVVNRHPYAYIPFSAGPRNC 447 Query: 1345 VGAEFSRIQIALFLHTLVTKYRWKEIKGGE 1434 +G F+ ++ + L L+ YR++ + E Sbjct: 448 IGQRFALLEEKVVLSYLLRHYRFRTVNKRE 477
>Q29488:CP2DH_MACFA Cytochrome P450 2D17 - Macaca fascicularis (Crab eating macaque)| (Cynomolgus monkey) Length = 497 Score = 92.0 bits (227), Expect = 7e-18 Identities = 112/485 (23%), Positives = 200/485 (41%), Gaps = 42/485 (8%) Frame = +1 Query: 166 RLPPGSMGLPLVGETFQF-FKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEV 342 R PPG + LP +G FK + P + Q +R+G VF L PVVV Sbjct: 32 RYPPGPLPLPGLGNLLHVDFK-----NTPYCFDQLRRRFGNVFSLQLAWTPVVVLNGLAA 86 Query: 343 NRFIFQQEGKLFRSWYPDTANNI--FGKES----IASYDGSFHKYVRSFASRL----FGL 492 R G+ P N + FG S +A Y ++ + R S L G Sbjct: 87 VREALVTCGEDTADRPPVPINQVLGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGK 146 Query: 493 DSLRDVLLAEMDC---NVTDSLAAWAAEPAIEVKDAVANMVFDLTAKKLIGFSPEKSRKL 663 SL + E C TD A P + AV+N++ LT + + + +L Sbjct: 147 KSLEQWVTEEAACLCAAFTDQ-AGRPFRPNSLLDKAVSNVIASLTYGRRFEYDDPRFLRL 205 Query: 664 RKNFDAFFQGL-------------VSFPLYFPGTTFYRCIQGRKNVQKVLKDLLKERLGA 804 FD + L + L PG + ++ +K L +LL E Sbjct: 206 ---FDLTHEALKEESGFLREVLNAIPLLLRIPGLAG-KVLRSQKAFLTQLDELLTEHRMT 261 Query: 805 --PEKRHGDFLDEVVDELQSGRGVIDEKFAVD----LMAALLFASFATVSSSLTIAMKFL 966 P + D + + E++ +G + F + ++A L A T S++L + + Sbjct: 262 WDPAQPPRDLTEAFLAEMEKAKGNPESSFNEENLRMVVADLFSAGMVTTSTTLAWGLLLM 321 Query: 967 SGHPNVVESLKEEHEAIL---KKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAP-G 1134 HP+V +++E + ++ ++ E G ++ M +T V +E+ R ++ P G Sbjct: 322 ILHPDVQRRVQQEIDDVIGQVRRPEMGDQA--------RMPYTTAVIHEVQRFGDIVPLG 373 Query: 1135 IFRKTLTDVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNF 1314 + T D++++G+ IP G + + +V + ++E P F+P + D + F Sbjct: 374 VTHMTSRDIELQGFLIPKGTTLFTNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAF 433 Query: 1315 MPFGGGIRLCVGAEFSRIQIALFLHTLVTKYRWKEIKGGEVQRISEIVF-----PEGYHI 1479 +PF G R C+G +R+++ LF L+ ++ + + G+ + VF P Y + Sbjct: 434 LPFSAGRRACLGEPLARMELFLFFTCLLQRFSF-SVPAGQPRPSHHGVFAFLVTPSPYEL 492 Query: 1480 QIIPR 1494 +PR Sbjct: 493 CAVPR 497
>O65790:C81F1_ARATH Cytochrome P450 81F1 - Arabidopsis thaliana (Mouse-ear cress)| Length = 500 Score = 92.0 bits (227), Expect = 7e-18 Identities = 62/231 (26%), Positives = 112/231 (48%), Gaps = 3/231 (1%) Frame = +1 Query: 754 KNVQKVLKDLLKERLGA--PEKRHGDFLDEVVDELQSGRGVIDEKFAVDLMAALLFASFA 927 K + K + D+L+ L +K ++ ++ Q + LM +++ A Sbjct: 244 KAIGKSMDDILQRLLDECRRDKEGNTMVNHLISLQQQQPEYYTDVIIKGLMMSMMLAGTE 303 Query: 928 TVSSSLTIAMKFLSGHPNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEI 1107 T + +L AM L +P V+E + E + + K +S I + + V +E Sbjct: 304 TSAVTLEWAMANLLRNPEVLEKARSEIDEKIGKDRLIDESDIA-----VLPYLQNVVSET 358 Query: 1108 SRVSNVAPGIFRKTLTD-VQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDE 1284 R+ VAP + ++ TD +++ GY +P +VM++ A+H +PE++E+P FNP R+ D Sbjct: 359 FRLFPVAPFLIPRSPTDDMKIGGYDVPRDTIVMVNAWAIHRDPEIWEEPEKFNPDRYNDG 418 Query: 1285 SKKSTMLKNFMPFGGGIRLCVGAEFSRIQIALFLHTLVTKYRWKEIKGGEV 1437 + MPFG G R C GA + + L L +L+ + W+ +KG E+ Sbjct: 419 CGSDYYVYKLMPFGNGRRTCPGAGLGQRIVTLALGSLIQCFEWENVKGEEM 469
>P58050:C71BD_ARATH Cytochrome P450 71B13 - Arabidopsis thaliana (Mouse-ear cress)| Length = 496 Score = 92.0 bits (227), Expect = 7e-18 Identities = 106/474 (22%), Positives = 189/474 (39%), Gaps = 33/474 (6%) Frame = +1 Query: 169 LPPGSMGLPLVGETFQF-FKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEVN 345 LPPG LP++G Q KP S+ + ++YGP+ L P VV+ E Sbjct: 29 LPPGPPRLPIIGNLHQLGSKPHRSMF------KLSEKYGPLVYLKLGKVPSVVASTPETV 82 Query: 346 RFIFQQEGKLFRS----WYPDTANNIFGKESIASYDGSFHKYVRSFASRLFG---LDSLR 504 + + + K S YP + + A Y + + L+ + S R Sbjct: 83 KDVLKTFDKDCCSRAFLTYPARISYNLKDLAFAPYSKYWKAVRKMTVVELYTAKRVKSFR 142 Query: 505 DVLLAEMDCNVTDSLAAWAAEPAIEVKDAVANMVFDLTAKKLIGFSPEKSRKLRKNFDAF 684 ++ E+ V + + E + + + + + + G + E S KL ++ Sbjct: 143 NIREEEVASFVEFIKHSASLEEIVNLNQTLVKLSGSVICRVGFGINLEGS-KLENTYEEV 201 Query: 685 FQGLVSFPLYFPGTTFYRCIQG--------RKNVQKVLK--DLLKERLGAPEKRHGDFLD 834 G + F + ++ I G +KV K D + G D Sbjct: 202 IHGTMEVLGSFAASDYFPVIGGIIDRITGLHNKCEKVFKGTDSFFDHCIKHHLEDGGSKD 261 Query: 835 EVVD--------ELQSGRGVIDEKFAVDLMAALLFASFATVSSSLTIAMKFLSGHPNVVE 990 ++VD E+ G ++ +L A T ++T M L +P V++ Sbjct: 262 DIVDLLLKVERGEIGLGEFQFTRNHTKGILLDILLAGVDTSGHTITWVMTHLIKNPRVMK 321 Query: 991 SLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAPGIF-RKTLTDVQV 1167 + E ++K K IT E+ + + + V E R++ + P + R+ DV++ Sbjct: 322 KAQAEVREVIKN-----KDNITEEDIEGLEYLKMVVKETLRINPLVPLLTPREASKDVKI 376 Query: 1168 KGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLK-NFMPFGGGIRLC 1344 GY IP + ++ A+H NP +++DP F P R+ D L +PFG G R+C Sbjct: 377 GGYNIPKKTWIHVNIWAIHRNPNVWKDPEAFIPERFMDNQIDYKGLNFELLPFGSGRRIC 436 Query: 1345 VGAEFSRIQIALFLHTLVTKYRWKEIKGGEVQRIS-----EIVFPEGYHIQIIP 1491 G I L L L+ ++ WK +G EV+ + +V P+ +++IP Sbjct: 437 PGIGMGMALIHLTLINLLYRFDWKLPEGMEVEDVDLEESYGLVCPKKVPLELIP 490
>P90771:C36A1_CAEEL Probable cytochrome P450 CYP36A1 - Caenorhabditis elegans| Length = 493 Score = 92.0 bits (227), Expect = 7e-18 Identities = 103/454 (22%), Positives = 196/454 (43%), Gaps = 39/454 (8%) Frame = +1 Query: 169 LPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEVNR 348 LPPG P +G TFQ P +D+ + K+YG +F T + P +V D ++ + Sbjct: 27 LPPGPTPWPFIGNTFQV--PEDRIDL--IINEFKKKYGGIF-TLWLPFPTIVICDYDMLK 81 Query: 349 FIFQQEGKLFRSWYPDTANN---IFGKESIASYDGSFHKYVRSFASRLF-----GLDSLR 504 + G+ F S PDT + G + + ++ K R F + +F G + Sbjct: 82 RNIVKNGESF-SGRPDTFIMDMLVQGNYGLFFMENNWWKAQRRFTTHIFRSLGVGQAGTQ 140 Query: 505 DVLLAEMDCNVTDSLAAWAAEPAIEVKDAVANMVFDLTAKKLIGFSPEKSRKLRKNFDAF 684 D + A + + + + +P IE++ + ++V ++ K L GF+ E + +F Sbjct: 141 DTI-ASLASGLVEKIDGQKDKP-IELRPLLVHVVGNVIHKHLFGFTREWNETEILDFHVA 198 Query: 685 FQGLVS----------------------FPLYFPGTTFYRCIQGRKN---VQKVLKDLLK 789 ++ L P TT R N +Q + + L K Sbjct: 199 INDVLEHFTSPKTQLLDAWPWLAYLDKPLSLGIPRTT-------RANDAIIQNLEQALAK 251 Query: 790 ERLGAP-EKRHGDFLDEVVDELQ--SGRGVIDEKFAVDLMAALLFASFATVSSSLTIAMK 960 + G ++ ++D + E++ + +++ F + ++ ++ ++ I ++ Sbjct: 252 HKTGINYDEEPSSYMDAFLKEMKIRAAENALEDGFTEKQLIVAIYDLYSAGMETIIIVLR 311 Query: 961 FLSGH-PNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAPGI 1137 F + N E+ K HE + R G + + ++ K + +T E+ R+ V P Sbjct: 312 FAFLYLVNNPETQKRIHEEL--DRNVGRERQVVMDDQKHLPYTCAFLQEVYRLGYVLPVN 369 Query: 1138 F-RKTLTDVQ-VKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKN 1311 F R TLTDV+ +GY + AG V+ +VH++ + F DP FNP R+ + + Sbjct: 370 FLRCTLTDVEDCEGYRLNAGTRVIAQFQSVHVDKKHFPDPEHFNPDRFLNSRGEYIRDDR 429 Query: 1312 FMPFGGGIRLCVGAEFSRIQIALFLHTLVTKYRW 1413 PF G R C+G +R+++ L+ TL+ + W Sbjct: 430 VNPFSMGKRSCLGENLARMEVFLYFCTLMQNFEW 463
>P33265:CP2CS_MESAU Cytochrome P450 2C28 - Mesocricetus auratus (Golden hamster)| Length = 490 Score = 91.7 bits (226), Expect = 9e-18 Identities = 107/475 (22%), Positives = 197/475 (41%), Gaps = 31/475 (6%) Frame = +1 Query: 163 GRLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEV 342 GRLPPG LPL+G Q S + F K YGPVF +P VV E Sbjct: 27 GRLPPGPTPLPLIGNILQIDIKDISKSLANFSKV----YGPVFTLYFGTKPTVVVHGYEA 82 Query: 343 NRFIFQQEGKLF--RSWYPDTANNIFGKESIASYDGSFHKYVRSFAS---RLFGLD--SL 501 + + G+ F R +P G I S +G+ K +R F+ R FG+ S+ Sbjct: 83 VKEALEDLGEEFSGRGNFPIVERMNSGLGIIFS-NGTKWKELRRFSLMTLRNFGMGKRSI 141 Query: 502 RDVLLAEMDCNVTD--SLAAWAAEPAIEVKDAVANMVFDLTAKKLIGFSPEK----SRKL 663 D + E C V + +P + A +N++ + ++ + KL Sbjct: 142 EDCIQEEARCLVEELRKTNGSPCDPTFFLSCAPSNVICSVVFHNRFDYNDKNFLNLMEKL 201 Query: 664 RKNFDAFFQG-------LVSFPLYFPGTTFYRCIQGRKNVQKVLKDLLKERLGAPEKRHG 822 +NF+ + +F Y PG+ + ++ ++ + +KE + + Sbjct: 202 NENFEILNSPWLQVCNVIPAFLDYLPGS-HNKALKNFAEIKSYILKRVKEHQETLDMNNP 260 Query: 823 -DFLDEVVDELQSGRGVIDEKFAVDLMAA----LLFASFATVSSSLTIAMKFLSGHPNVV 987 DF+D + +++ + +F + + A + A T S++L + L H V Sbjct: 261 RDFIDCFLIKMEKEKDNPHSEFTTESLMATVADVFVAGSETTSTTLRYGLLLLLKHKEVT 320 Query: 988 ESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAPGIFRKTLT-DVQ 1164 +++E + ++ G ++ M +T + +E+ R N+ P T +V+ Sbjct: 321 AKVQKEIDHVI-----GRDRSPCMQDRTRMPYTDAMVHEVQRYVNLIPNNVPHAATCNVK 375 Query: 1165 VKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGIRLC 1344 + Y IP G ++ S +V + + F +P F+P + DE+ FMPF G R+C Sbjct: 376 FRNYVIPKGTDLITSLTSVLHDDKEFPNPKIFDPAHFLDENGNFKKSDYFMPFSIGKRMC 435 Query: 1345 VGAEFSRIQIALFLHTLVTKYRWKEIKGGEVQRISEIV-----FPEGYHIQIIPR 1494 +G +R+++ L L T++ + K + + + + P Y + IPR Sbjct: 436 MGEALARMELFLLLTTILQNFDLKSLADTKDIDTTPVASTFGCVPPSYQLYFIPR 490
>P19225:CP270_RAT Cytochrome P450 2C70 - Rattus norvegicus (Rat)| Length = 489 Score = 91.7 bits (226), Expect = 9e-18 Identities = 101/448 (22%), Positives = 181/448 (40%), Gaps = 25/448 (5%) Frame = +1 Query: 166 RLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEVN 345 +LPPG LP+ G Q + S + K+ YGPVF L +P VV EV Sbjct: 28 KLPPGPTPLPIFGNILQVGVKNISKSMCMLAKE----YGPVFTMYLGMKPTVVLYGYEVL 83 Query: 346 RFIFQQEGKLFRS-WYPDTANNIFGKESIASYDGSFHKYVRSFA-----SRLFGLDSLRD 507 + G+ F + + + I +G K R F+ S G ++ + Sbjct: 84 KEALIDRGEEFSDKMHSSMLSKVSQGLGIVFSNGEIWKQTRRFSLMVLRSMGMGKRTIEN 143 Query: 508 VLLAEMD--CNVTDSLAAWAAEPAIEVKDAVANMVFDLTAKKLIGFSPEKSRKLRKNFDA 681 + E+ +P+ + N++ + + +S EK +K +NF Sbjct: 144 RIQEEVVYLLEALRKTNGSPCDPSFLLACVPCNVISSVIFQHRFDYSDEKFQKFIENFHT 203 Query: 682 FFQGLVS--------FPL--YFPG--TTFYRCIQGRKNVQKVLKDLLKERLGAPEKRHGD 825 + L S +P+ Y PG F + + +K +L ++ + R D Sbjct: 204 KIEILASPWAQLCSAYPVLYYLPGIHNKFLKDVTEQKKF--ILMEINRHRASLNLSNPQD 261 Query: 826 FLDEVVDELQSGRGVIDEKFAVDLMAA----LLFASFATVSSSLTIAMKFLSGHPNVVES 993 F+D + +++ + +F +D + L A T SS++ + L +P V Sbjct: 262 FIDYFLIKMEKEKHNEKSEFTMDNLIVTIGDLFGAGTETTSSTIKYGLLLLLKYPEVTAK 321 Query: 994 LKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAP-GIFRKTLTDVQVK 1170 ++EE ++ + ++ M +T V +EI R + P + RKT DV+ + Sbjct: 322 IQEEITRVIGRHRRPCM-----QDRNHMPYTDAVLHEIQRYIDFVPIPLPRKTTQDVEFR 376 Query: 1171 GYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGIRLCVG 1350 GY IP G VM + + + F +P F+P + DE FM F G R C+G Sbjct: 377 GYHIPKGTSVMACLTSALHDDKEFPNPEKFDPGHFLDEKGNFKKSDYFMAFSAGRRACIG 436 Query: 1351 AEFSRIQIALFLHTLVTKYRWKEIKGGE 1434 +R+++ L L +++ + K + E Sbjct: 437 EGLARMEMFLILTSILQHFTLKPLVNPE 464
>O42430:CP1A1_LIMLI Cytochrome P450 1A1 - Limanda limanda (Dab)| Length = 521 Score = 91.7 bits (226), Expect = 9e-18 Identities = 127/498 (25%), Positives = 211/498 (42%), Gaps = 45/498 (9%) Frame = +1 Query: 94 LAAVVAGWLAHCVYKWTNPACSTG-RLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRL 270 L A+ L + + K+ G R PG LP++G + P L + A K Sbjct: 18 LVAMTTVCLVYLILKFFQTEIPEGLRRLPGPKPLPIIGNVLEMGS-RPYLSLTAMSK--- 73 Query: 271 KRYGPVFKTSLVGQPVVVSMDAEVNRFIFQQEGKLFRSWYPDTANNIF---GKESIASYD 441 RYG VF+ + +PVVV +E R ++G F PD + F GK S D Sbjct: 74 -RYGNVFQIQIGMRPVVVLSGSETVRQALIKQGDDFAG-RPDLYSFRFINEGKSLAFSTD 131 Query: 442 GS---------FHKYVRSFASRLFGLDSLRDVLLAEMDCNVTDSL---------AAWAAE 567 + + +RSFA+ L G +L E C + L A + + Sbjct: 132 KAGIWRARRKLAYSALRSFAT-LEGTTPEYSCVLEEHVCKEGEYLIKQLNTAMTADGSFD 190 Query: 568 PAIEVKDAVANMV--------FDLTAKKLIGF---SPEKSRKLRKNFDAFFQGLVSFPLY 714 P + +VAN++ +D ++L+G S E R + A F ++ Y Sbjct: 191 PFRHIVVSVANVICGMCFGRRYDHDDQELVGLVTLSDEFGRVVGSGNPADFIPILQ---Y 247 Query: 715 FPGTTFYRCIQGRKNVQKVLKDLLKERLGAPEKRH-GDFLDEVVDELQ-------SGRGV 870 P T ++ + ++ ++ E +K + D D ++D + S + Sbjct: 248 LPSATMKNFLRINGRFTEFVQKIVTEHYTTFDKDNIRDITDSLIDHCEDRKLDENSNVQM 307 Query: 871 IDEKFAVDLMAALLFASFATVSSSLTIAMKFLSGHPNVVESLKEEHEAILKKREEGAKSG 1050 DEK V ++ L A F TVS++L+ ++ +L HP + E L +E E + G Sbjct: 308 SDEKI-VGIVNDLFGAGFDTVSTALSWSVMYLVAHPEIQERLYQEIED-----KVGLDRM 361 Query: 1051 ITWEEYKSMTFTAQVTNEISRVSNVAP-GIFRKTLTDVQVKGYTIPAGWLVMISPMAVHL 1227 + ++ F EI R S+ P I T D + GY IP V I+ ++ Sbjct: 362 PLLSDKPNLPFLEAFILEILRHSSFLPFTIPHCTTKDTSLNGYFIPKDTCVFINQWQINH 421 Query: 1228 NPELFEDPLTFNPWRW--QDESKKSTM-LKNFMPFGGGIRLCVGAEFSRIQIALFLHTLV 1398 +PE+++DP +FNP R+ D S+ + + + M FG G R C+G +R ++ LFL L+ Sbjct: 422 DPEMWKDPSSFNPDRFLSADGSEVNKLDGEKVMAFGMGKRRCIGEVIARNEVYLFLAILI 481 Query: 1399 TKYRWKEIKGGEVQRISE 1452 K + I G ++ E Sbjct: 482 QKLHFLPIPGEKLDMTPE 499
>Q98T91:C340_ORYLA Cytochrome P450 3A40 - Oryzias latipes (Medaka fish) (Japanese| ricefish) Length = 502 Score = 91.7 bits (226), Expect = 9e-18 Identities = 62/215 (28%), Positives = 106/215 (49%), Gaps = 5/215 (2%) Frame = +1 Query: 808 EKRHGDFLDEVVDELQSGRGVIDEKFAVD---LMAALLF--ASFATVSSSLTIAMKFLSG 972 +K DFL ++D ++ + + +K D L A++F A + T SSSLT L+ Sbjct: 265 QKSRIDFLQLMIDSQKNNQNGLQDKGLSDHEILSQAMIFIFAGYETTSSSLTFLAYNLAT 324 Query: 973 HPNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAPGIFRKTL 1152 +P V++ L++E +A K+ + + M + V NE R+ +A + R Sbjct: 325 NPEVMKKLQKEIDATFPN-----KAPVQYVPLMEMEYLDCVVNESLRLYPIAARLERVAK 379 Query: 1153 TDVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGG 1332 V+V G IP +VM+ +H +PEL+ +P F P R+ E+K + +MPFG G Sbjct: 380 ATVEVNGLVIPKDMVVMVPTWPLHRDPELWPEPEKFKPERFSKENKDTFDPYTYMPFGAG 439 Query: 1333 IRLCVGAEFSRIQIALFLHTLVTKYRWKEIKGGEV 1437 R C+G F+ + + L + ++ Y + K EV Sbjct: 440 PRNCIGMRFALVMMKLAVVEILQTYDFSVCKETEV 474
>Q64481:CP3AG_MOUSE Cytochrome P450 3A16 - Mus musculus (Mouse)| Length = 504 Score = 91.3 bits (225), Expect = 1e-17 Identities = 99/447 (22%), Positives = 188/447 (42%), Gaps = 26/447 (5%) Frame = +1 Query: 175 PGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEVNRFI 354 PG LP +G ++K D+ + K YG + P+ V D E + + Sbjct: 39 PGPKPLPFLGTVLNYYKGLWKFDMECYEK-----YGKTWGLFDGQIPLFVITDPETIKNV 93 Query: 355 FQQEG-KLFRSWYPDTANNIFGKESIASYDGSFHKYVRSFASRLFGLDSLRDVL-LAEMD 528 +E +F + I K + D + +Y R+ S F +L+++ + E Sbjct: 94 LVKECFSVFTNRQDFFPVGIMSKSISLAKDEEWKRY-RALLSPTFTSGNLKEMFPVIEQY 152 Query: 529 CNVTDSLAAWAAEPA--IEVKDAVANMVFDLTAKKLIGFS------PE----KSRKLRKN 672 ++ AE + VKD + D+ G + PE ++ K Sbjct: 153 GDILVKYLRQEAEKGKPVAVKDVLGAYSMDVIISTTFGVNIDSLNNPEDPFVENAKKVLR 212 Query: 673 FDAFFQGLVSFPLYFPGTTFYR----CIQGRKNVQ---KVLKDLLKERLGAPEKRHGDFL 831 FD F +S L+ T Y C+ + +++ K + + + RL + +K DF+ Sbjct: 213 FDYFDPLSLSVALFPFLTPIYEMLNICMFPKDSIEFFKKFVDRMTENRLDSKQKHRVDFI 272 Query: 832 DEVVDELQSGRGVIDEKFAVDLMAA-----LLFASFATVSSSLTIAMKFLSGHPNVVESL 996 +++ + K ++ +FA + T SS L+ + L+ HP++ + L Sbjct: 273 YLMMEAYNKSKDKDSHKALSEIEITAQSIIFIFAGYETTSSILSFTVYSLATHPDIQKKL 332 Query: 997 KEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAPGIFRKTLTDVQVKGY 1176 +EE + L K+ T++ +M + V NE R+ + + R DV++ G Sbjct: 333 QEEIDEALPN-----KAPPTYDTVMAMEYLDMVLNETLRLYPITNRLQRVCKKDVEINGI 387 Query: 1177 TIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGIRLCVGAE 1356 IP G V+I +H +P+ + +P F P R+ E+K S ++PFG G R C+G Sbjct: 388 YIPKGSTVIIPSYVLHHDPQHWPEPEEFQPERFSKENKGSIDPYVYLPFGNGPRNCIGMR 447 Query: 1357 FSRIQIALFLHTLVTKYRWKEIKGGEV 1437 F+ + + L L ++ + ++ K ++ Sbjct: 448 FALMNMKLALIKVLQNFSFQPCKETQI 474
>P79383:CP2E1_PIG Cytochrome P450 2E1 - Sus scrofa (Pig)| Length = 495 Score = 91.3 bits (225), Expect = 1e-17 Identities = 106/479 (22%), Positives = 201/479 (41%), Gaps = 33/479 (6%) Frame = +1 Query: 157 STGRLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDA 336 S+ +LPPG LP+VG FQ ++P + +RYGPVF L + +VV Sbjct: 28 SSWKLPPGPFPLPIVGNIFQL----DLKNIPKSFTMLAERYGPVFTVYLGSRRIVVLHGY 83 Query: 337 EVNRFIFQQEGKLFRSWYPDTANNIFGKESIASYDGSFHKYVRSFAS---RLFGLDSLRD 507 + + + F + + + +G + R F+ R FG+ + Sbjct: 84 KAVKEVLLHYKNEFSGRGEIPTFQVHKDKGVIFNNGPTWRDTRRFSLTTLRDFGMGKQGN 143 Query: 508 VLLAEMDCN-VTDSLAAWAAEP---AIEVKDAVANMVFDLTAKKLIGFSPEKSRKLRKNF 675 + + + + ++L +P + A N++ D+ ++ ++ + +L F Sbjct: 144 EQRIQREAHFLLEALRKTHGQPFDPTFLIGCAPCNVISDILFRQHFDYNDKTCLRLMSMF 203 Query: 676 DAFFQGLVS--FPLYFPGTTFYRCIQGR-----KNVQKVLKDLLKERLGAPEKRHGD--- 825 + F L + LY + + R + G KN+ ++ KD ER+ K H D Sbjct: 204 NENFYLLSTGWIQLYNNFSGYLRYLPGSHRKLMKNISEI-KDYALERV----KDHRDSLE 258 Query: 826 ------FLDEVVDELQSGRGVIDEKFAVDLMAA----LLFASFATVSSSLTIAMKFLSGH 975 F D ++ E++ + + + +D +A + FA T S++L + L + Sbjct: 259 PSCPRDFTDTLLMEMEKEKYSAEPIYTLDNIAVTVADMFFAGTETTSTTLRYGLLILMKY 318 Query: 976 PNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAPGIFRKTLT 1155 P V E L EE + ++ G ++ M + V +EI R ++ P T Sbjct: 319 PEVEEKLHEEIDRVI-----GPNRIPAIKDRLVMPYLDAVVHEIQRFIDLIPSNLPHEAT 373 Query: 1156 -DVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGG 1332 D + Y IP G +V+ + +V + + F +P F P + +E+ K +F F G Sbjct: 374 RDTDFRDYIIPKGTVVIPTLDSVLYDSQEFPEPEKFKPEHFLNENGKFKYSDHFKAFSAG 433 Query: 1333 IRLCVGAEFSRIQIALFLHTLVTKYRWKEIKGGEVQRISEIV-----FPEGYHIQIIPR 1494 R+CVG +R+++ LF+ ++ + K + + +S I P Y + +IPR Sbjct: 434 KRVCVGEGLARMELFLFMAAILQHFNLKSLVDPKDIDLSPIAIGFAKIPPHYKLCVIPR 492
>P20813:CP2B6_HUMAN Cytochrome P450 2B6 - Homo sapiens (Human)| Length = 491 Score = 91.3 bits (225), Expect = 1e-17 Identities = 121/510 (23%), Positives = 198/510 (38%), Gaps = 45/510 (8%) Frame = +1 Query: 100 AVVAGWLAHCVYKWTNPACSTGRLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRY 279 A++ G L V + N + RLPPG LPL+G Q + + +F + R ++Y Sbjct: 10 ALLTGLLLLLVQRHPN---THDRLPPGPRPLPLLGNLLQMDRRGL---LKSFLRFR-EKY 62 Query: 280 GPVFKTSLVGQPVVVSMDAEVNRFIFQQEGKLFRSWYPDTANNIFGKESIASYDGSFHKY 459 G VF L +PVV+ E R D A G+ IA D F Y Sbjct: 63 GDVFTVHLGPRPVVMLCGVEA-----------IREALVDKAEAFSGRGKIAMVDPFFRGY 111 Query: 460 VRSFAS-------RLFGLDSLRDV----------LLAEMDCNVTDSLAAWAA--EPAIEV 582 FA+ R F + ++RD + E C + + + A +P Sbjct: 112 GVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLF 171 Query: 583 KDAVANMVFDLTAKKLIGFSPEKSRKL-----------RKNFDAFFQGLVSFPLYFPGTT 729 + AN++ + K + ++ K+ F F+ F YFPG Sbjct: 172 QSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGA- 230 Query: 730 FYRCIQGRKNVQKVLK----DLLKERLGAPEKRHGDFLDEVVDELQSGRGVIDEKFAVDL 897 +R Q KN+Q++ + K R D +D + ++ + +F+ Sbjct: 231 -HR--QVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQN 287 Query: 898 M----AALLFASFATVSSSLTIAMKFLSGHPNVVESLKEEHEAILKKREEGAKSGITWEE 1065 + +L FA T S++L + +P+V E + E E ++ G + Sbjct: 288 LNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVI-----GPHRPPELHD 342 Query: 1066 YKSMTFTAQVTNEISRVSNVAP-GIFRKTLTDVQVKGYTIPAGWLV-MISPMAVHLNPEL 1239 M +T V EI R S++ P G+ +GY IP V +I A+H +P Sbjct: 343 RAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALH-DPHY 401 Query: 1240 FEDPLTFNPWRWQDESKKSTMLKNFMPFGGGIRLCVGAEFSRIQIALFLHTLVTKYRWKE 1419 FE P FNP + D + + F+PF G R+C+G +R ++ LF T++ + Sbjct: 402 FEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMAS 461 Query: 1420 IKGGE-----VQRISEIVFPEGYHIQIIPR 1494 E Q P Y I+ +PR Sbjct: 462 PVAPEDIDLTPQECGVGKIPPTYQIRFLPR 491
>O81973:C93A3_SOYBN Cytochrome P450 93A3 - Glycine max (Soybean)| Length = 510 Score = 91.3 bits (225), Expect = 1e-17 Identities = 115/490 (23%), Positives = 205/490 (41%), Gaps = 40/490 (8%) Frame = +1 Query: 169 LPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEVNR 348 LPP M LP++G P+P D F+K L RYGP+ L P VV+ AE + Sbjct: 31 LPPSPMPLPIIGH-LHLLSPTPHQD---FHKLSL-RYGPIIHLFLGSVPCVVASTAEAAK 85 Query: 349 FIFQQEGKLFRSWYPDTA---NNIFGKESI--ASYDGSFHKYVRSFA-SRLFG---LDSL 501 + F + +T +G + A Y G + K+++ S L G LD Sbjct: 86 EFLKTHEPAFSNRPANTVAVETLTYGFQDFLFAPY-GPYWKFMKKLCMSELLGGHMLDQF 144 Query: 502 RDVLLAEMDCNVTDSLAAWAAEPAIEV--------KDAVANMVFDLTAKKLIGFSPEKSR 657 V E + L + A++ + V+ M+ T+ E+ R Sbjct: 145 LPVRQXETKKFIKRVLQKGISGEAVDFGGEFITLSNNIVSRMIVSQTSTTEDENEVEEMR 204 Query: 658 KLRKNFDAF-----FQGLVSFPLYFPGTTFYRCIQGRKN-----VQKVLKDLLKERLGAP 807 KL K+ VSF F F + ++ ++ + +++K +ER Sbjct: 205 KLVKDAAELSGKFNISDFVSFLKRFDLQGFNKRLEKIRDCFDTVLDRIIKQREEERRNKN 264 Query: 808 E----KRHGDFLDEVVD--ELQSGRGVIDEKFAVDLMAALLFASFATVSSSLTIAMKFLS 969 E + D LD + D E +S ++++ + +L A T + ++ AM L Sbjct: 265 ETVGKREFKDMLDVLFDISEDESSEIKLNKENIKAFILDILIAGTDTSAVTMEWAMAELI 324 Query: 970 GHPNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAPGIFRKT 1149 +P V+E ++E +A++ K +S I ++ + + E R+ P +FR++ Sbjct: 325 NNPGVLEKARQEMDAVVGKSRIVEESDIA-----NLPYLQGIVRETLRLHPAGPLLFRES 379 Query: 1150 LTDVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLK----NFM 1317 V GY IPA + ++ A+ +P +E+PL F P R+ + K ++ + + Sbjct: 380 SRRAVVCGYDIPAKTRLFVNVWAIGRDPNHWENPLEFRPERFVENGKSQLDVRGQHYHLL 439 Query: 1318 PFGGGIRLCVGAEFSRIQIALFLHTLVTKYRWK-EIKGGEV--QRISEIVFPEGYHIQII 1488 PFG G R C G + + + L L+ ++WK + G+V + + I P + I + Sbjct: 440 PFGSGRRACPGTSLALQVVHVNLAVLIQCFQWKVDCDNGKVNMEEKAGITLPRAHPIICV 499 Query: 1489 PREG*NDSPI 1518 P N P+ Sbjct: 500 PIRRLNPFPV 509
>Q86W10:CP4Z1_HUMAN Cytochrome P450 4Z1 - Homo sapiens (Human)| Length = 505 Score = 90.9 bits (224), Expect = 2e-17 Identities = 70/253 (27%), Positives = 115/253 (45%), Gaps = 5/253 (1%) Frame = +1 Query: 736 RCIQGRKNVQKVLKDLLKERLGAPEKRHGDFLDEVVDELQSGRGVIDEKFAVDLMAALLF 915 + IQ RK + LKD LK+ +KR DFLD ++ E + +F Sbjct: 259 KVIQDRK---ESLKDKLKQ--DTTQKRRWDFLDILLSAKSENTKDFSEADLQAEVKTFMF 313 Query: 916 ASFATVSSSLTIAMKFLSGHPNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQV 1095 A T SS+++ + L+ +P + ++E +L G S ITWE M +T Sbjct: 314 AGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELL-----GDGSSITWEHLSQMPYTTMC 368 Query: 1096 TNEISRVSNVAPGIFRKTLTDVQVK---GYTIPAGWLVMISPMAVHLNPELFEDPLTFNP 1266 E R+ AP + L D + G ++PAG V I+ A+H NP +EDP FNP Sbjct: 369 IKECLRL--YAPVVNISRLLDKPITFPDGRSLPAGITVFINIWALHHNPYFWEDPQVFNP 426 Query: 1267 WRWQDESKKSTMLKNFMPFGGGIRLCVGAEFSRIQIALFLHTLVTKYRWKEIKGGEVQRI 1446 R+ E+ + F+PF G+R C+G F+ I+ + + + +++ Q + Sbjct: 427 LRFSRENSEKIHPYAFIPFSAGLRNCIGQHFAIIECKVAVALTLLRFKLAPDHSRPPQPV 486 Query: 1447 SEIVF--PEGYHI 1479 ++V G H+ Sbjct: 487 RQVVLKSKNGIHV 499
>O18809:CP2F3_CAPHI Cytochrome P450 2F3 - Capra hircus (Goat)| Length = 491 Score = 90.9 bits (224), Expect = 2e-17 Identities = 102/449 (22%), Positives = 183/449 (40%), Gaps = 27/449 (6%) Frame = +1 Query: 142 TNPACSTGRLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVV 321 T + GRLPPG LP +G Q S D+ + K +G V+ L + VV Sbjct: 21 TTSSKGKGRLPPGPRALPFLGNLLQL----RSQDMLTSLTKLSKEFGAVYTVYLGPRRVV 76 Query: 322 V--SMDAEVNRFIFQQEGKLFRSWYPDTANNIFGKESIASYDGSFHKYVRSFASRLF--- 486 V A + Q E R YP N G IA +G K +R ++ ++ Sbjct: 77 VLSGYQAVKEALVDQAEEFSGRGDYPAFFNFTKGN-GIAFSNGDRWKALRKYSLQILRNF 135 Query: 487 --GLDSLRDVLLAEMDCNVTDSLAAWAA--EPAIEVKDAVANMVFDLTAKKLIGFSPEKS 654 G ++ + +L E + + +P V +V+N++ + + ++ Sbjct: 136 GMGKRTIEERILEEGHFLLEELRKTQGKPFDPTFVVSRSVSNIICSVIFGSRFDYDDDRL 195 Query: 655 RKLRKNFDAFFQGLVS--------FPLYF-----PGTTFYRCIQGRKNVQKVLKDLLKER 795 + + FQ + S FP P ++ KN+ + + + + + Sbjct: 196 LTIIHLINENFQIMSSPWGEMYNIFPNLLDWVPGPHRRLFKNYGRMKNL--IARSVREHQ 253 Query: 796 LGAPEKRHGDFLDEVVDELQSGRGVIDEKFAVDLMAA----LLFASFATVSSSLTIAMKF 963 DF+D + ++ + F +D + LLF TV ++L A + Sbjct: 254 ASLDPNSPRDFIDCFLTKMAQEKQDPLSHFFMDTLLMTTHNLLFGGTETVGTTLRHAFRL 313 Query: 964 LSGHPNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAP-GIF 1140 L +P V ++EE + ++ G + T E+ M +T V +E+ R +++ P + Sbjct: 314 LMKYPEVQVRVQEEIDRVV-----GRERLPTVEDRAEMPYTDAVIHEVQRFADIIPMSLP 368 Query: 1141 RKTLTDVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMP 1320 + D +G+TIP G V+ VH +P F P FNP + D + FMP Sbjct: 369 HRVTRDTNFRGFTIPRGTDVITLLNTVHYDPSQFLKPKEFNPEHFLDANMSFKKSPAFMP 428 Query: 1321 FGGGIRLCVGAEFSRIQIALFLHTLVTKY 1407 F G RLC+G +R+++ L+L ++ + Sbjct: 429 FSAGRRLCLGEALARMELFLYLTAILQSF 457
>Q9QYG5:CP2DK_MESAU Cytochrome P450 2D20 - Mesocricetus auratus (Golden hamster)| Length = 500 Score = 90.9 bits (224), Expect = 2e-17 Identities = 107/466 (22%), Positives = 195/466 (41%), Gaps = 34/466 (7%) Frame = +1 Query: 166 RLPPGSMGLPLVGETFQF-FKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEV 342 R PPG M LP +G Q F+ P + YK + +RYG VF + +PVVV + Sbjct: 35 RYPPGPMPLPGLGNLLQVDFENMPY----SLYKFQ-QRYGDVFSLQMAWKPVVVINGLKA 89 Query: 343 NRFIFQQEGKLFRSWYPDTANNIFGKESIASYDGSFHKYVRSFAS-RLFGLDSLRDVLLA 519 R + G+ P N G S F +Y + R F + ++RD + Sbjct: 90 VREVLVNCGEDTADRPPVPIFNHLGYRP-KSQGVVFARYGPQWREQRRFSVSTMRDFGVG 148 Query: 520 EMD------------CNVTDSLAAWAAEPAIEVKDAVANMVFDLTAKKLIGFSPEKSRKL 663 + C+ A P + +V N++ L + KL Sbjct: 149 KKSLEQWVTEEAGHLCDAFTQEAGHPFNPITLLNKSVCNVISSLIYAHRFDYEDPFFNKL 208 Query: 664 RKNFDAFF--------QGLVSFPLYF-----PGTTFYRCIQGRKNVQKVLKDLLKERLGA 804 K F + L + P+ PG F + ++ K+L + + Sbjct: 209 LKTLQESFGEDSGFIAEVLNAVPVLLRIPGLPGKAFPKLTAFMDSLYKMLIE--HKTTWD 266 Query: 805 PEKRHGDFLDEVVDELQSGRGVIDEKFAVD----LMAALLFASFATVSSSLTIAMKFLSG 972 P + D + E++ +G + F + ++A L A T S++L+ A+ + Sbjct: 267 PAQPPRGLTDAFLAEVEKAKGRPESSFNDENLHVVVADLFIAGMVTTSTTLSWALLLMIL 326 Query: 973 HPNVVESLKEEHEAILK--KREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAP-GIFR 1143 HP+V +++E + ++ +R E A + M +T V +E+ R ++AP + Sbjct: 327 HPDVQSRVQQEIDDVIGQVRRPEMA-------DQARMPYTNAVIHEVQRFGDIAPVNVPH 379 Query: 1144 KTLTDVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPF 1323 T DV+V+G+ IP G ++ + +V + ++E PL F+P + D + + FMPF Sbjct: 380 MTSRDVEVQGFLIPKGTTLIPNLSSVLKDETVWEKPLHFHPEHFLDAQGRFVKQEAFMPF 439 Query: 1324 GGGIRLCVGAEFSRIQIALFLHTLVTKYRWKEIKGGEVQRISEIVF 1461 G R C+G +R+++ LF L+ ++ + + G+ + + VF Sbjct: 440 SAGRRACLGEPLARMELFLFFTCLLQRFSF-SVPAGQPRPSDQGVF 484
>P50859:CP51_CANGA Cytochrome P450 51 - Candida glabrata (Yeast) (Torulopsis glabrata)| Length = 533 Score = 90.5 bits (223), Expect = 2e-17 Identities = 93/443 (20%), Positives = 184/443 (41%), Gaps = 49/443 (11%) Frame = +1 Query: 253 FYKQRLKRYGPVFKTSLVGQPVVVSMDAEVNRFIFQQE--GKLFRSWYPDTANNIFGKES 426 F++ K+YG +F L+G+ + V + + + FIF + + Y +FGK Sbjct: 80 FFEDCQKKYGDIFSFMLLGRIMTVYLGPKGHEFIFNAKLADVSAEAAYSHLTTPVFGKGV 139 Query: 427 I-----------------ASYDGSFHKYVRSFASRLFG-LDSLRDVLLAEMDCNVTDSLA 552 I A +F +YV A ++ + ++ + E + + D + Sbjct: 140 IYDCPNHRLMEQKKFVKGALTKEAFVRYVPLIAEEIYKYFRNSKNFKINENNSGIVDVMV 199 Query: 553 AWAAEPAIEVKDAVANMVFDLTAKKLIGFSPEKSRKLRKNFDAFF----QGLVSFPLYFP 720 + +P + + A ++ L+G E KL +F + +G FP Sbjct: 200 S---QPEMTIFTA---------SRSLLG--KEMRDKLDTDFAYLYSDLDKGFTPINFVFP 245 Query: 721 GTTFYRCIQGRKNVQKVLK----DLLKERLGAPEKRHGDFLDEVVDE--LQSGRGVIDEK 882 + R + Q+ + L+KER + ++ D +DE++ + G + D++ Sbjct: 246 NLPLEH-YRKRDHAQQAISGTYMSLIKERREKNDIQNRDLIDELMKNSTYKDGTKMTDQE 304 Query: 883 FAVDLMAALLFASFATVSSSLTIAMKFLSGHPNVVESLKEEHEAILKKREEGAKSGITWE 1062 A +L+ +L T +++ + L+ P+V E L +E +L + +T++ Sbjct: 305 IA-NLLIGVLMGGQHTSAATSAWCLLHLAERPDVQEELYQEQMRVLNNDTKE----LTYD 359 Query: 1063 EYKSMTFTAQVTNEISRVSNVAPGIFRKTLTDVQVKG--YTIPAGWLVMISPMAVHLNPE 1236 + ++M Q+ E R+ + +FRK + DV + Y +P + V++SP HL E Sbjct: 360 DLQNMPLLNQMIKETLRLHHPLHSLFRKVMRDVAIPNTSYVVPRDYHVLVSPGYTHLQEE 419 Query: 1237 LFEDPLTFNPWRWQDESKKST-----------------MLKNFMPFGGGIRLCVGAEFSR 1365 F P FN RW ++ S+ + ++PFGGG C+G F+ Sbjct: 420 FFPKPNEFNIHRWDGDAASSSAAGGDEVDYGFGAISKGVSSPYLPFGGGRHRCIGELFAY 479 Query: 1366 IQIALFLHTLVTKYRWKEIKGGE 1434 Q+ + + + +W+ GE Sbjct: 480 CQLGVLMSIFIRTMKWRYPTEGE 502
>P24461:CP2G1_RABIT Cytochrome P450 2G1 - Oryctolagus cuniculus (Rabbit)| Length = 494 Score = 90.5 bits (223), Expect = 2e-17 Identities = 100/452 (22%), Positives = 187/452 (41%), Gaps = 37/452 (8%) Frame = +1 Query: 163 GRLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEV 342 GRLPPG +P +G Q +F K R ++YGPVF + +PVV+ E Sbjct: 31 GRLPPGPTPIPFLGNLLQV---RTDATFQSFLKLR-EKYGPVFTVYMGPRPVVILCGHEA 86 Query: 343 NRFIFQQEGKLFRSWYPDTANNIFGKESIASYDGSFHKYVRSFAS-------RLFGLDSL 501 + D A+ G+ +AS + +F + + A+ R F L L Sbjct: 87 -----------VKEALVDRADEFSGRGELASVERNFQGHGVALANGERWRILRRFSLTIL 135 Query: 502 RDVLLAEMDCNVTDSLAAWAA--------------EPAIEVKDAVANMVFDLTAKKLIGF 639 RD + + ++ + + A +P + V+N++ + + Sbjct: 136 RDFGMGKR--SIEERIQEEAGYLLEEFRKTKGAPIDPTFFLSRTVSNVISSVVFGSRFDY 193 Query: 640 SPEKSRKLRKNFDAFFQGLVS--FPLYFPGTTFYRCIQGRKN----VQKVLKDLLKERLG 801 ++ L + + F + + LY + + + GR N + + LKD + R+ Sbjct: 194 EDKQFLSLLRMINESFIEMSTPWAQLYDMYSGVMQYLPGRHNRIYYLIEELKDFIAARVK 253 Query: 802 APE-----KRHGDFLDEVVDELQSGRGVIDEKFAVDLMAA----LLFASFATVSSSLTIA 954 E + DF+D + ++ + +F + + L FA TVSS+L Sbjct: 254 VNEASLDPQNPRDFIDCFLIKMHQDKNNPHTEFNLKNLVLTTLNLFFAGTETVSSTLRYG 313 Query: 955 MKFLSGHPNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAP- 1131 + HP V + EE ++ G + ++ M FT V +EI R++++ P Sbjct: 314 FLLIMKHPEVQTKIYEEINQVI-----GPHRIPSVDDRVKMPFTDAVIHEIQRLTDIVPM 368 Query: 1132 GIFRKTLTDVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKN 1311 G+ + D +GY +P G V +V +P+ F P F P + DE + + Sbjct: 369 GVPHNVIRDTHFRGYLLPKGTDVFPLLGSVLKDPKYFCHPDDFYPQHFLDEQGRFKKNEA 428 Query: 1312 FMPFGGGIRLCVGAEFSRIQIALFLHTLVTKY 1407 F+PF G R+C+G +R+++ L+ +++ + Sbjct: 429 FVPFSSGKRICLGEAMARMELFLYFTSILQNF 460
>Q05421:CP2E1_MOUSE Cytochrome P450 2E1 - Mus musculus (Mouse)| Length = 493 Score = 90.5 bits (223), Expect = 2e-17 Identities = 106/472 (22%), Positives = 192/472 (40%), Gaps = 30/472 (6%) Frame = +1 Query: 169 LPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEVNR 348 LPPG +P G FQ D+P + KR+GPVF L + +VV + + Sbjct: 32 LPPGPFPIPFFGNIFQL----DLKDIPKSLTKLAKRFGPVFTLHLGQRRIVVLHGYKAVK 87 Query: 349 FIFQQEGKLFRSWYPDTANNIFGKESIASYDGSFHKYVRSFA---SRLFGLDSLRDVLLA 519 + F + + I +G K VR F+ R +G+ + Sbjct: 88 EVLLNHKNEFSGRGDIPVFQEYKNKGIIFNNGPTWKDVRRFSLSILRDWGMGKQGNEARI 147 Query: 520 EMDCN-VTDSLAAWAA---EPAIEVKDAVANMVFDLTAKKLIGFSPEKSRKLRKNFDAFF 687 + + + + + L +P + A N++ D+ K + +K +L F+ F Sbjct: 148 QREAHFLVEELKKTKGQPFDPTFLIGCAPCNVIADILFNKRFDYDDKKCLELMSLFNENF 207 Query: 688 QGLVSFPLYFPGTTFYRCIQ----GRKNVQKVLKDLLKERLGAPEKRHGDFLD-----EV 840 L+S P F +Q + V K + ++ + LG K H LD +V Sbjct: 208 Y-LLSTPWIQAYNYFSDYLQYLPGSHRKVMKNVSEIRQYTLG-KAKEHLKSLDINCPRDV 265 Query: 841 VD----ELQSGRGVIDEKFAVD----LMAALLFASFATVSSSLTIAMKFLSGHPNVVESL 996 D E++ + + + ++ +A L FA T S++L + L +P + E L Sbjct: 266 TDCLLIEMEKEKHSQEPMYTMENISVTLADLFFAGTETTSTTLRYGLLILMKYPEIEEKL 325 Query: 997 KEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAP-GIFRKTLTDVQVKG 1173 EE + ++ G + +M + V +EI R N+ P + + D +G Sbjct: 326 HEEIDRVI-----GPSRAPAVRDRMNMPYMDAVVHEIQRFINLVPSNLPHEATRDTVFRG 380 Query: 1174 YTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGIRLCVGA 1353 Y IP G +V+ + ++ + F DP TF P + +E+ K F F G R+CVG Sbjct: 381 YVIPKGTVVIPTLDSLLFDNYEFPDPETFKPEHFLNENGKFKYSDYFKAFSAGKRVCVGE 440 Query: 1354 EFSRIQIALFLHTLVTKYRWKEIKGGEVQRISEIV-----FPEGYHIQIIPR 1494 +R+++ L L ++ + K + + +S + P + + +IPR Sbjct: 441 GLARMELFLLLSAILQHFNLKSLVDPKDIDLSPVTIGFGSIPREFKLCVIPR 492
>P10635:CP2D6_HUMAN Cytochrome P450 2D6 - Homo sapiens (Human)| Length = 497 Score = 90.5 bits (223), Expect = 2e-17 Identities = 116/515 (22%), Positives = 212/515 (41%), Gaps = 44/515 (8%) Frame = +1 Query: 82 SLCGLAAVVAGWLA-----HCVYKWTNPACSTGRLPPGSMGLPLVGETFQFFKPSPSLDV 246 +L LA +VA +L H +W R PPG + LP +G + Sbjct: 5 ALVPLAVIVAIFLLLVDLMHRRQRWA------ARYPPGPLPLPGLGNLLHV----DFQNT 54 Query: 247 PAFYKQRLKRYGPVFKTSLVGQPVVV--SMDAEVNRFIFQQEGKLFRSWYPDTANNIFGK 420 P + Q +R+G VF L PVVV + A + E R P T FG Sbjct: 55 PYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGP 114 Query: 421 ESIASYDGSFHKYVRSFASRLFGLDSLRDVLLAEMDCN--VTDSLAAWAA---------- 564 S + + R R F + +LR++ L + VT+ A A Sbjct: 115 RSQGVFLARYGPAWRE--QRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPF 172 Query: 565 EPAIEVKDAVANMVFDLTAKKLIGFSPEKSRKLR-------KNFDAFFQGL---VSFPLY 714 P + AV+N++ LT + + + +L K F + + V L+ Sbjct: 173 RPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLH 232 Query: 715 FPGTTFYRCIQGRKNVQKVLKDLLKERLGA--PEKRHGDFLDEVVDELQSGRGVIDEKFA 888 P + ++ +K L +LL E P + D + + E++ +G + F Sbjct: 233 IPALAG-KVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFN 291 Query: 889 VD----LMAALLFASFATVSSSLTIAMKFLSGHPNVVESLKEEHEAIL---KKREEGAKS 1047 + ++A L A T S++L + + HP+V +++E + ++ ++ E G ++ Sbjct: 292 DENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQA 351 Query: 1048 GITWEEYKSMTFTAQVTNEISRVSNVAP-GIFRKTLTDVQVKGYTIPAGWLVMISPMAVH 1224 M +T V +E+ R ++ P G+ T D++V+G+ IP G ++ + +V Sbjct: 352 --------HMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVL 403 Query: 1225 LNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGIRLCVGAEFSRIQIALFLHTLVTK 1404 + ++E P F+P + D + F+PF G R C+G +R+++ LF +L+ Sbjct: 404 KDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQH 463 Query: 1405 YRWKEIKGGEVQRISEIVF-----PEGYHIQIIPR 1494 + + + G+ + VF P Y + +PR Sbjct: 464 FSF-SVPTGQPRPSHHGVFAFLVSPSPYELCAVPR 497
>P13107:CP2B3_RAT Cytochrome P450 2B3 - Rattus norvegicus (Rat)| Length = 491 Score = 90.5 bits (223), Expect = 2e-17 Identities = 114/462 (24%), Positives = 189/462 (40%), Gaps = 47/462 (10%) Frame = +1 Query: 163 GRLPPGSMGLPLVGETFQFFKPSPSLDVPAFYK---QRLKRYGPVFKTSLVGQPVVVSMD 333 G LPPG LPL+G Q +D F K Q +++G VF +PVV+ Sbjct: 28 GHLPPGPRPLPLLGNLLQ-------MDRGGFRKSFIQLQEKHGDVFTVYFGPRPVVMLCG 80 Query: 334 AEVNRFIFQQEGKLFRSWYPDTANNIFGKESIASYDGSFHKYVRSFAS--------RLF- 486 + R D A G+ IA +Y SF + RLF Sbjct: 81 TQT-----------IREALVDHAEAFSGRGIIAVLQPIMQEYGVSFVNEERWKILRRLFV 129 Query: 487 --------GLDSLRDVLLAEMDCNVTD--SLAAWAAEPAIEVKDAVANMVFDLTAKKLIG 636 G S+ D + E C V + + + +P + N++ + + Sbjct: 130 ATMRDFGIGKQSVEDQIKEEAKCLVEELKNHQGVSLDPTFLFQCVTGNIICSIVFGERFD 189 Query: 637 FSPEKSRKLR----------KNFDA-FFQGLVSFPLYFPGTTFYRCIQGRKNVQKVLKDL 783 + + +L +F + F+ F YFPG + + K LK++ Sbjct: 190 YRDRQFLRLLDLLYRTFSLISSFSSQMFEVYSDFLKYFPGV--------HREIYKNLKEV 241 Query: 784 L--------KERLGAPEKRHGDFLDEVVDELQSGR-GVIDEKFAVDLMAALLFASFA-TV 933 L R DF+D + ++ + E +LM ++LF A T Sbjct: 242 LDYIDHSVENHRATLDPNAPRDFIDTFLLHMEKEKLNHYTEFHHWNLMISVLFLFLAGTE 301 Query: 934 SSSLTIAMKFLS--GHPNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEI 1107 S+S T+ FL +P+V E +++E + ++ G++ T ++ M +T V +EI Sbjct: 302 STSNTLCYGFLLMLKYPHVAEKVQKEIDQVI-----GSQRVPTLDDRSKMPYTEAVIHEI 356 Query: 1108 SRVSNVAP-GIFRKTLTDVQVKGYTIPAGWLV-MISPMAVHLNPELFEDPLTFNPWRWQD 1281 R S+V+P G+ + D +GY +P V I A+H +P+ FE P TFNP + D Sbjct: 357 QRFSDVSPMGLPCRITKDTLFRGYLLPKNTEVYFILSSALH-DPQYFEQPDTFNPEHFLD 415 Query: 1282 ESKKSTMLKNFMPFGGGIRLCVGAEFSRIQIALFLHTLVTKY 1407 + + FMPF G R+C+G +R ++ LF T++ Y Sbjct: 416 ANGALKKCEAFMPFSIGKRMCLGEGIARSELFLFFTTILQNY 457
>Q92095:CP1A1_OPSTA Cytochrome P450 1A1 - Opsanus tau (Oyster toadfish)| Length = 521 Score = 90.5 bits (223), Expect = 2e-17 Identities = 127/502 (25%), Positives = 207/502 (41%), Gaps = 47/502 (9%) Frame = +1 Query: 64 SQVAFASLCGLAAVVAGWLAHCVYKWTNPACSTGRLPPGSMGLPLVGETFQFF-KPSPSL 240 S VA ++C + ++ Y T RLP G LP++G + KP +L Sbjct: 17 SLVALITICVVYLILT-------YSHTKIPAGLQRLP-GPKPLPIIGNVLEIGRKPYQTL 68 Query: 241 DVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEVNRFIFQQEGKLFRSWYPDTANNIF-- 414 + KRYGPVF+ + +PVVV +E R ++G+ F S PD F Sbjct: 69 TALS------KRYGPVFQIQIGMRPVVVLSGSETVRQALIKQGEDF-SGRPDLYTFQFIS 121 Query: 415 -GKESIASYDGS---------FHKYVRSFASRLFGLDSLRDVLLAEMDCNVTDSL----- 549 GK S D + +RSF+S L + +L E C + L Sbjct: 122 DGKSLAFSTDKVGVWRARRKLAYSALRSFSS-LESTNQEYSCMLEEHICKEGEYLVKQLN 180 Query: 550 ----AAWAAEPAIEVKDAVANMV-----------FDLTAKKLIGFSPEKSRKLRKNFDAF 684 A + +P + +VAN++ +D L+ S E + + A Sbjct: 181 TSMKANGSFDPFRNIVVSVANVICGMCFGRRYDHYDQELVSLVNLSEEFGQVVGTGNLAD 240 Query: 685 FQGLVSFPLYFPGTTFYRCIQGRKNVQKVLKDLLKERLGAPEKRH-GDFLDEVVDELQSG 861 F ++ F P T + + K +K ++ E K + D D ++D + Sbjct: 241 FIPVLRF---LPSTAMKKFLSINDRFDKFVKKIVSEHYATYNKDNIRDITDSLIDHCEDR 297 Query: 862 R-------GVIDEKFAVDLMAALLFASFATVSSSLTIAMKFLSGHPNVVESLKEEHEAIL 1020 + V DEK V ++ L A F TVS+ L+ ++ +L +P + E L +E Sbjct: 298 KLDENCNVQVSDEKI-VGIVNDLFGAGFDTVSTGLSWSVMYLVAYPEIQERLYQEI---- 352 Query: 1021 KKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAP-GIFRKTLTDVQVKGYTIPAGWL 1197 K G + + S+ F EI R S+ P I T + + GY IP Sbjct: 353 -KDSVGTERMPLLSDRPSLPFLDAFILEIFRHSSFLPFTIPHCTTKNTSLNGYFIPKDTC 411 Query: 1198 VMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTML-----KNFMPFGGGIRLCVGAEFS 1362 V I+ ++ +PEL++DP +FNP R+ S T L + M FG G R C+G + Sbjct: 412 VFINQWQINHDPELWKDPFSFNPERFL--SADGTELNRLEGEKVMLFGLGKRRCIGEVIA 469 Query: 1363 RIQIALFLHTLVTKYRWKEIKG 1428 R ++ LFL ++ + ++ + G Sbjct: 470 RNEVFLFLAIIIQRLQFHMLPG 491
>Q95078:CP18A_DROME Cytochrome P450 18a1 - Drosophila melanogaster (Fruit fly)| Length = 538 Score = 90.5 bits (223), Expect = 2e-17 Identities = 108/443 (24%), Positives = 188/443 (42%), Gaps = 37/443 (8%) Frame = +1 Query: 166 RLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEVN 345 +LPPG GLP++G + F S + + + K+YG +F T L Q VV D ++ Sbjct: 52 KLPPGPWGLPVIG--YLLFMGS---EKHTRFMELAKQYGSLFSTRLGSQLTVVMSDYKMI 106 Query: 346 RFIFQQEGKLFRSWYPDTA-NNIFGKESIASYDGSFHKYVRSFAS---RLFGLDSL---R 504 R F++E R PDT I + G K R F R FG+ + + Sbjct: 107 RECFRREEFTGR---PDTPFMQTLNGYGIINSTGKLWKDQRRFLHDKLRQFGMTYMGNGK 163 Query: 505 DVLLAEMDCNVTDSLAAWAAE--------PAIEVKDAVANMVFDLTAKKLIGFSPEKSRK 660 + + V + + A P I V AV+N++ L K R+ Sbjct: 164 QQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISV--AVSNVICSLMMSTRFSIDDPKFRR 221 Query: 661 LRKNFDAFFQ--GLVSFPLYFP--------GTTFYRCIQGRKNVQKVLKDLLKERLGAPE 810 + + G + Y P T + Q R +Q+ +D++ + + + Sbjct: 222 FNFLIEEGMRLFGEIHTVDYIPTMQCFPSISTAKNKIAQNRAEMQRFYQDVIDDHKRSFD 281 Query: 811 KRH-GDFLDEVVDELQSGR----------GVIDEKFAVDLMAALLFASFATVSSSLTIAM 957 + D +D + E++ + G E+ V ++ L A T+ ++L Sbjct: 282 PNNIRDLVDFYLCEIEKAKAEGTDAELFDGKNHEEQLVQVIIDLFSAGMETIKTTLLWIN 341 Query: 958 KFLSGHPNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAPGI 1137 F+ +P + +++E + ++ G T E+ + + T E R S++ P Sbjct: 342 VFMLRNPKEMRRVQDELDQVV-----GRHRLPTIEDLQYLPITESTILESMRRSSIVPLA 396 Query: 1138 FRKTLT-DVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNF 1314 + T DV++ GYTIPAG V+ +VH++P L+E P F P R+ D K + F Sbjct: 397 TTHSPTRDVELNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYF 456 Query: 1315 MPFGGGIRLCVGAEFSRIQIALF 1383 +PFG G R+C+G +R+++ LF Sbjct: 457 IPFGVGRRMCLGDVLARMELFLF 479
>O73853:CP17A_ICTPU Cytochrome P450 17A1 - Ictalurus punctatus (Channel catfish)| Length = 514 Score = 90.5 bits (223), Expect = 2e-17 Identities = 102/468 (21%), Positives = 199/468 (42%), Gaps = 45/468 (9%) Frame = +1 Query: 166 RLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEVN 345 R PP LP++G SP F++Q K+YG ++ + V++ + Sbjct: 31 RAPPNLPSLPIIGSLLSINSNSPP---HIFFQQLQKKYGDIYSLDMGSNRVIIVNNHHHA 87 Query: 346 RFIFQQEGKLFRSWYPDTANNIFGKES--IASYDGS----FHKYVRSFASRLFG--LDSL 501 + + ++GK+F +I ++ IA D S FH+ + A +FG S+ Sbjct: 88 KEVLLRKGKIFAGRPRTVTTDILTRDGKDIAFGDYSATWKFHRKIVHGALCMFGEGTASI 147 Query: 502 RDVLLAEMD--CNVTDSLAAWAAEPAIEVKDAVANMVFDLT-AKKLIGFSPEKSRKLRKN 672 ++ E C + +L + AA+ A E+ AV N+V L + PE L+ Sbjct: 148 EKIICREASSMCEILTNLQSSAADLAPELTRAVTNVVCTLCFSSSYKRGDPEFEAMLK-- 205 Query: 673 FDAFFQGLV------SFPLYFPGTTFY---------RCIQGRK----------------N 759 + QG+V S FP + RC+ R N Sbjct: 206 ---YSQGIVDTVAKDSLVDIFPWLQLFPNEDLRILRRCVSIRDKLLQKKYEEHKADFSDN 262 Query: 760 VQKVLKDLLKERLGAPEKRHGDFLDEVVDELQSGRGVIDEKFAVDLMAALLFASFATVSS 939 +Q+ L D L + E + D G+ D+ + + + A T ++ Sbjct: 263 IQRDLFDALLRAKNSSENNNTSTQDV---------GLTDDHLLMTV-GDIFGAGVETTTT 312 Query: 940 SLTIAMKFLSGHPNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVS 1119 L ++ +L HP V ++EE +A + + + + ++ + E+ R+ Sbjct: 313 VLKWSILYLIHHPQVQRKIQEELDAKIGRDRHPQVN-----DRGNLPYLEATIREVLRIR 367 Query: 1120 NVAPGIF-RKTLTDVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKS 1296 V+P + L+D + YT+ G V+++ ++H + + +++P FNP R+ +E S Sbjct: 368 PVSPLLIPHVALSDANIGEYTVQKGTRVIVNLWSLHHDEKEWKNPELFNPERFLNEEGNS 427 Query: 1297 TMLKN--FMPFGGGIRLCVGAEFSRIQIALFLHTLVTKYRWKEIKGGE 1434 + ++PFG G+R+C+G +++++ LFL ++ ++ E+ GG+ Sbjct: 428 LCCPSLSYLPFGAGVRVCLGEALAKLELFLFLSWILQRFT-LEVPGGQ 474
>Q9V771:C6A23_DROME Probable cytochrome P450 6a23 - Drosophila melanogaster (Fruit fly)| Length = 502 Score = 90.5 bits (223), Expect = 2e-17 Identities = 82/292 (28%), Positives = 137/292 (46%), Gaps = 16/292 (5%) Frame = +1 Query: 586 DAVANMVFDLTAKKLIGFSPE-KSRKLRKNFDAFFQGLVSFPLY-FPGTTFYRCIQGRKN 759 D + N F L L + E + R + + GL+ F ++ FP + R ++ + N Sbjct: 184 DVIGNCAFGLNCNSLQNPNAEFVTIGKRAIIERRYGGLLDFLIFGFPKLS--RRLRLKLN 241 Query: 760 VQKV-------LKDLLKERLGAPEKRHGDFLD---EVVDELQSGRGVIDEKFAVDLMAAL 909 VQ V +++ + RL EKRH DF+D E+ ++ Q+G F L A Sbjct: 242 VQDVEDFYTSIVRNTIDYRLRTNEKRH-DFMDSLIEMYEKEQAGNTEDGLSFNEILAQAF 300 Query: 910 LF--ASFATVSSSLTIAMKFLSGHPNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTF 1083 +F A F T S+++ A+ L+ ++ + L+ E +L K + T+E K M + Sbjct: 301 IFFVAGFETSSTTMGFALYELALDQDIQDQLRAEINNVLSKHN----NEFTYEGIKEMKY 356 Query: 1084 TAQVTNEISRVSNVAPGIFRKTLTDVQVKG--YTIPAGWLVMISPMAVHLNPELFEDPLT 1257 QV E R V + R T TD + Y I G V+I + +H +PE++ +P Sbjct: 357 LEQVVMETLRKYPVLAHLTRMTQTDFSPEDPKYFIAKGTTVVIPALGIHYDPEIYPEPEK 416 Query: 1258 FNPWRWQDESKKSTMLKNFMPFGGGIRLCVGAEFSRIQIALFLHTLVTKYRW 1413 F P R+ DE+ + ++PFG G R C+G F +Q + L L+ Y++ Sbjct: 417 FKPERFTDEAIAARPSCTWLPFGEGPRNCIGLRFGLMQACVGLAYLIRGYKF 468
>Q9V4U7:C6A14_DROME Probable cytochrome P450 6a14 - Drosophila melanogaster (Fruit fly)| Length = 509 Score = 90.5 bits (223), Expect = 2e-17 Identities = 62/228 (27%), Positives = 120/228 (52%), Gaps = 14/228 (6%) Frame = +1 Query: 772 LKDLLKERLGAPEKRHGDFLDEVVD-------ELQSGRGV-IDEKFAVDLMAALLF---- 915 +K+ + RL KR+ DF++++++ + G+G+ + ++ MAA F Sbjct: 254 VKNTVDYRLKNGIKRN-DFIEQMIELRAEDQEAAKKGQGIDLSHGLTLEQMAAQAFVFFV 312 Query: 916 ASFATVSSSLTIAMKFLSGHPNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQV 1095 A F T SS++++ + L+ P++ + L+EE E++L + G + ++ MT+ QV Sbjct: 313 AGFETSSSTMSLCLYELALQPDIQQRLREEIESVLANVDGGE---LNYDVLAQMTYLDQV 369 Query: 1096 TNEISRVSNVAPGIFRKTLTDVQVKGYTI--PAGWLVMISPMAVHLNPELFEDPLTFNPW 1269 +E R + P + R+T D Q+ I G L +I +H +PE++ +P F+P Sbjct: 370 LSETLRKHPLLPHLIRETTKDYQIPNSDIVLDKGILALIPVHNIHHDPEIYPEPEKFDPS 429 Query: 1270 RWQDESKKSTMLKNFMPFGGGIRLCVGAEFSRIQIALFLHTLVTKYRW 1413 R+ E K+ ++PFG G R C+G F +IQ + L +L+ ++++ Sbjct: 430 RFDPEEVKNRHPMAYLPFGDGPRNCIGLRFGKIQAKIGLVSLLRRFKF 477
>Q64417:CP3AE_CAVPO Cytochrome P450 3A14 - Cavia porcellus (Guinea pig)| Length = 503 Score = 90.1 bits (222), Expect = 3e-17 Identities = 98/447 (21%), Positives = 193/447 (43%), Gaps = 26/447 (5%) Frame = +1 Query: 175 PGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEVNRFI 354 PG LPL G + K S D+ K+YG ++ QPV+ + ++ + + Sbjct: 39 PGPKPLPLFGNVLSYRKGMWSFDIEC-----RKKYGNMWGLYDGPQPVLAITEPDMIKAV 93 Query: 355 FQQEGKLFRSWYPDTANNIFGKESIASYDGSFHKYVRSFASRLFGLDSLRDV--LLAEMD 528 +E + F K++++ + K +R+ S F L+++ ++ + Sbjct: 94 LVKECYSVFTNRRSLVPVGFMKKAVSLSEDEEWKRIRTQLSPNFTSGKLKEMFPIIKQYG 153 Query: 529 CNVTDSLAAWAAE-PAIEVKDAVANMVFDLTAKKLIGFSPE-----------KSRKLRKN 672 + +L A + +++K+ D+ G + + K+RKL + Sbjct: 154 DVLVKNLRQEAEKGKPVQLKEIFGAYSMDIIVATAFGVNVDSLNNPHDPFVSKARKLFR- 212 Query: 673 FDAFFQGLVSFPLYFPGTTFYRCIQ-------GRKNVQKVLKDLLKERLGAPEKRHGDFL 831 FD L+S ++ T Y + K K +K + L + +K+ DFL Sbjct: 213 FDFLSPFLLSIVMFPFLTQLYEMLSISIFPRDSLKFFTKFVKKTKENHLESNKKQRVDFL 272 Query: 832 DEVVD-----ELQSGRGVIDEKFAVDLMAALLFASFATVSSSLTIAMKFLSGHPNVVESL 996 +++ + +S + + D + + +FA + T SS+L+ M L+ HP+V + L Sbjct: 273 QMMLNSQNFKDTESHKALSDVEILAQSII-FIFAGYETTSSTLSFIMYSLATHPDVQKKL 331 Query: 997 KEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAPGIFRKTLTDVQVKGY 1176 ++E + L K+ T++ M + V NE R+ V I R + D ++ G Sbjct: 332 QQEIDKTLPN-----KAFPTYDVMMEMEYLDMVVNETLRLYPVTNRIERMSKKDFEINGM 386 Query: 1177 TIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGIRLCVGAE 1356 + P G VMI A+H + + + +P F P R+ ++K++ +MPFG G R C+G Sbjct: 387 SFPKGTGVMIPSFALHRDSKYWPEPDEFRPERFSKKNKENIDPYIYMPFGNGPRNCIGMR 446 Query: 1357 FSRIQIALFLHTLVTKYRWKEIKGGEV 1437 + + + L L L+ + + K ++ Sbjct: 447 MALMNLKLALIRLLQNFSFYPCKETQI 473
>P10610:CP2G1_RAT Cytochrome P450 2G1 - Rattus norvegicus (Rat)| Length = 494 Score = 90.1 bits (222), Expect = 3e-17 Identities = 104/449 (23%), Positives = 188/449 (41%), Gaps = 29/449 (6%) Frame = +1 Query: 163 GRLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLK---RYGPVFKTSLVGQPVVV--S 327 G+LPPG +P +G Q + + A ++ LK +YG VF +PVV+ Sbjct: 31 GKLPPGPTPIPFLGNLLQ-------VRIDATFQSFLKLQKKYGSVFTVYFGPRPVVILCG 83 Query: 328 MDAEVNRFIFQQEGKLFRSWYPDTANNIFGKESIASYDGSFHKYVRSFAS---RLFGLD- 495 +A + Q + R P N G +A +G K +R F+ R FG+ Sbjct: 84 HEAVKEALVDQADDFSGRGEMPTLEKNFQGY-GLALSNGERWKILRRFSLTVLRNFGMGK 142 Query: 496 -SLRDVLLAEMDCNVTDSLAAWAA--EPAIEVKDAVANMVFDLTAKKLIGFSPEKSRKLR 666 S+ + + E + + A +P + V+N++ + K + ++ R L Sbjct: 143 RSIEERIQEEAGYLLEELHKVKGAPIDPTFYLSRTVSNVICSVVFGKRFDYEDQRFRSLM 202 Query: 667 KNFDAFFQGLVSFPLYFPGTTFYRCIQ---GRKN----VQKVLKDLLKERLGAPEKRHG- 822 K + F + S P ++ IQ GR N + + LKD + R+ E Sbjct: 203 KMINESFVEM-SMPWAQLYDMYWGVIQYFPGRHNRLYNLIEELKDFIASRVKINEASFDP 261 Query: 823 ----DFLDEVVDELQSGRGVIDEKFAVDLMAA----LLFASFATVSSSLTIAMKFLSGHP 978 DF+D + ++ + +F + + L FA TVSS+L L +P Sbjct: 262 SNPRDFIDCFLIKMYQDKSDPHSEFNLKNLVLTTLNLFFAGTETVSSTLRYGFLLLMKYP 321 Query: 979 NVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAP-GIFRKTLT 1155 V + EE ++ G ++ M +T V +EI R++++ P G+ + Sbjct: 322 EVEAKIHEEINQVI-----GTHRTPRVDDRAKMPYTDAVIHEIQRLTDIVPLGVPHNVIR 376 Query: 1156 DVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGI 1335 D +GY +P G V +V +P+ F P F P + DE + F+ F G Sbjct: 377 DTHFRGYFLPKGTDVYPLIGSVLKDPKYFRYPEAFYPQHFLDEQGRFKKNDAFVAFSSGK 436 Query: 1336 RLCVGAEFSRIQIALFLHTLVTKYRWKEI 1422 R+CVG +R+++ L+ +++ ++ + + Sbjct: 437 RICVGEALARMELFLYFTSILQRFSLRSL 465
>Q9Y6A2:CP46A_HUMAN Cytochrome P450 46A1 - Homo sapiens (Human)| Length = 500 Score = 89.7 bits (221), Expect = 3e-17 Identities = 84/407 (20%), Positives = 177/407 (43%), Gaps = 21/407 (5%) Frame = +1 Query: 271 KRYGPVFKTSLVGQP-VVVSMDAEVNRFI----FQQEGKLFRSWYPDTANNIFGKESIAS 435 K+YGPV + ++ + V+V+ V +F+ + ++ K++R+ +FG+ ++ Sbjct: 69 KKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSE 128 Query: 436 YDGS-FHKYVRSF-----ASRLFGL--------DSLRDVLLAEMDCNVTDSLAAWAAEPA 573 + +HK R S L L + L ++L A+ D S+ A Sbjct: 129 CNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTA 188 Query: 574 IEVKDAVANMVFDLTAKKLIGFSPEKSRKLRKNFDAFFQGLVSFPLYFPGTT--FYRCIQ 747 +++ +A F + L+G S+ ++ + + + PG + Sbjct: 189 MDI---LAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRE 245 Query: 748 GRKNVQKVLKDLLKERLGAPEKRHGDFLDEVVDELQSGRGVIDEKFAVDLMAALLFASFA 927 + +++V +D ++ R A ++ D + L++ G D++ +D A Sbjct: 246 SIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEEGAQDDEGLLDNFVTFFIAGHE 305 Query: 928 TVSSSLTIAMKFLSGHPNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEI 1107 T ++ L + LS P +V L+ E + ++ G+K + +E+ + + +QV E Sbjct: 306 TSANHLAFTVMELSRQPEIVARLQAEVDEVI-----GSKRYLDFEDLGRLQYLSQVLKES 360 Query: 1108 SRVSNVAPGIFRKTLTDVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDES 1287 R+ A G FR + + G +P ++ S + FEDPLTFNP R+ + Sbjct: 361 LRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGA 420 Query: 1288 KKSTMLKNFMPFGGGIRLCVGAEFSRIQIALFLHTLVTKYRWKEIKG 1428 K + PF G R C+G +F+++++ + + L+ + ++ + G Sbjct: 421 PKPRF--TYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPG 465
>P11509:CP2A6_HUMAN Cytochrome P450 2A6 - Homo sapiens (Human)| Length = 494 Score = 89.7 bits (221), Expect = 3e-17 Identities = 108/496 (21%), Positives = 191/496 (38%), Gaps = 50/496 (10%) Frame = +1 Query: 157 STGRLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLK---RYGPVFKTSLVGQPVVVS 327 S G+LPPG LP +G Q L+ Y +K RYGPVF L + VVV Sbjct: 29 SKGKLPPGPTPLPFIGNYLQ-------LNTEQMYNSLMKISERYGPVFTIHLGPRRVVVL 81 Query: 328 MDAEVNRFIFQQEGKLFRSWYPDTANNIFGKESIASYDGSFHKYVRSFAS-------RLF 486 + R D A G+ A++D F Y F++ R F Sbjct: 82 CGHDA-----------VREALVDQAEEFSGRGEQATFDWVFKGYGVVFSNGERAKQLRRF 130 Query: 487 GLDSLRDVLLAEMDCN---------VTDSLAAWAA---EPAIEVKDAVANMV-------- 606 + +LRD + + + D+L +P + V+N++ Sbjct: 131 SIATLRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFGDR 190 Query: 607 FDLTAKKLIG----------FSPEKSRKLRKNFDAFFQGLVSFPLYFPGTTFYRCIQGRK 756 FD K+ + F+ + +L + F + + L P ++ +QG + Sbjct: 191 FDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPG-----PQQQAFQLLQGLE 245 Query: 757 NVQKVLKDLLKERLGAPEKRHGDFLDEVVDELQSGRGVIDEKFAVDLMAA----LLFASF 924 + + K + + DF+D + +Q + +F + + L Sbjct: 246 DF--IAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGT 303 Query: 925 ATVSSSLTIAMKFLSGHPNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNE 1104 TVS++L L HP V + EE + ++ K + +E+ M + V +E Sbjct: 304 ETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPK-----FEDRAKMPYMEAVIHE 358 Query: 1105 ISRVSNVAP-GIFRKTLTDVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQD 1281 I R +V P + R+ D + + + +P G V +V +P F +P FNP + + Sbjct: 359 IQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLN 418 Query: 1282 ESKKSTMLKNFMPFGGGIRLCVGAEFSRIQIALFLHTLVTKYRWKEIKGGE-----VQRI 1446 E + F+PF G R C G +R+++ LF T++ +R K + + + + Sbjct: 419 EKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHV 478 Query: 1447 SEIVFPEGYHIQIIPR 1494 P Y + +PR Sbjct: 479 GFATIPRNYTMSFLPR 494
>O23976:C76B1_HELTU Cytochrome P450 76B1 - Helianthus tuberosus (Jerusalem artichoke)| Length = 490 Score = 89.7 bits (221), Expect = 3e-17 Identities = 60/219 (27%), Positives = 106/219 (48%), Gaps = 3/219 (1%) Frame = +1 Query: 769 VLKDLLKERLGAPEKRHGDFLDEVVDELQSGRGVIDEKFAVDLMAALLFASFATVSSSLT 948 + L++ER+ GD LD + +Q + L L A T S ++ Sbjct: 244 IFDQLIEERMRTGRFEQGDVLDVCLKMMQDNPNEFNHTNIKALFLDLFVAGTDTTSITIE 303 Query: 949 IAMKFLSGHPNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVA 1128 AM L P+++ KEE E ++ G S + ++ + + + + E+ R+ + Sbjct: 304 WAMTELLRKPHIMSKAKEELEKVI-----GKGSIVKEDDVLRLPYLSCIVKEVLRLHPPS 358 Query: 1129 PGIF-RKTLTDVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTML 1305 P + RK +T V++ GYTIPAG LV ++ A+ +P +++D L F P R+ ES+ Sbjct: 359 PLLLPRKVVTQVELSGYTIPAGTLVFVNAWAIGRDPTVWDDSLEFKPQRFL-ESRLDVRG 417 Query: 1306 KNF--MPFGGGIRLCVGAEFSRIQIALFLHTLVTKYRWK 1416 +F +PFG G R+C G + + + L +L+ + WK Sbjct: 418 HDFDLIPFGAGRRICPGIPLATRMVPIMLGSLLNNFDWK 456
>Q8N118:CP4X1_HUMAN Cytochrome P450 4X1 - Homo sapiens (Human)| Length = 509 Score = 89.4 bits (220), Expect = 4e-17 Identities = 63/208 (30%), Positives = 105/208 (50%), Gaps = 6/208 (2%) Frame = +1 Query: 805 PEKRHGDFLDEVV---DELQSGRGVIDEKFAVDLMAALLFASFATVSSSLTIAMKFLSGH 975 P++++ DFLD V+ DE S ID V + L A T+++S++ + L+ + Sbjct: 279 PKRKYQDFLDIVLSAKDESGSSFSDIDVHSEV---STFLLAGHDTLAASISWILYCLALN 335 Query: 976 PNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAPGIFR---K 1146 P E +EE IL G S ITW++ M++T E R+ P I R K Sbjct: 336 PEHQERCREEVRGIL-----GDGSSITWDQLGEMSYTTMCIKETCRLIPAVPSISRDLSK 390 Query: 1147 TLTDVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFG 1326 LT G T+PAG V++S +H NP ++++P F+P R+ E+ ++PF Sbjct: 391 PLTFPD--GCTLPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFSQENSDQRHPYAYLPFS 448 Query: 1327 GGIRLCVGAEFSRIQIALFLHTLVTKYR 1410 G R C+G EF+ I++ + + ++ +R Sbjct: 449 AGSRNCIGQEFAMIELKVTIALILLHFR 476
>O42563:CP3AR_ONCMY Cytochrome P450 3A27 - Oncorhynchus mykiss (Rainbow trout) (Salmo| gairdneri) Length = 518 Score = 89.4 bits (220), Expect = 4e-17 Identities = 98/442 (22%), Positives = 178/442 (40%), Gaps = 31/442 (7%) Frame = +1 Query: 175 PGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEVNRFI 354 PG LP G ++ K + D F K YG ++ QPV+ MD + + + Sbjct: 40 PGPKPLPYFGTMLEYKKGFTNFDTECFQK-----YGRIWGIYDGRQPVLCIMDKSMIKTV 94 Query: 355 FQQEG-KLFRSWYPDTANN-IFGKESIASYDGSFHKYVRSFASRLFGLDSLRDV--LLAE 522 +E +F + N +F S+A D + +RS S F L+++ ++ + Sbjct: 95 LIKECYNIFTNRRNFHLNGELFDALSVAEDDT--WRRIRSVLSPSFTSGRLKEMFGIMKQ 152 Query: 523 MDCNVTDSLAAWA-AEPAIEVKDAVANMVFDLTAKKLIGFSPEKSRKLRKNFDAFFQGLV 699 + + A + IEVK+ D+ + F + + ++ Sbjct: 153 HSSTLLSGMKKQADKDQTIEVKEFFGPYSMDVVTSTAFSVDIDSLNNPSDPFVSNVKKML 212 Query: 700 SFPLYFPGTTFYRCIQGRKNVQKVLK--------------DLLKERLGAP---EKRHGDF 828 F L+ P + + +K L K + G DF Sbjct: 213 KFDLFNPLFLLVALFPFTGPILEKMKFSFFPTAVTDFFYASLAKIKSGRDTGNSTNRVDF 272 Query: 829 LDEVVDELQSG---------RGVIDEKFAVDLMAALLFASFATVSSSLTIAMKFLSGHPN 981 L ++D + +G+ D + M +FA + T SS+++ L+ + + Sbjct: 273 LQLMIDSQKGSDTKTGEEQTKGLTDHEILSQAMI-FIFAGYETSSSTMSFLAYNLATNHH 331 Query: 982 VVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAPGIFRKTLTDV 1161 V+ L+EE + + K+ I +E M + V NE R+ +AP + R V Sbjct: 332 VMTKLQEEIDTVFPN-----KAPIQYEALMQMDYLDCVLNESLRLYPIAPRLERVAKKTV 386 Query: 1162 QVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGIRL 1341 ++ G IP +V++ +H +PE++ DP F P R+ E+K+S +MPFG G R Sbjct: 387 EINGIVIPKDCIVLVPTWTLHRDPEIWSDPEEFKPERFSKENKESIDPYTYMPFGAGPRN 446 Query: 1342 CVGAEFSRIQIALFLHTLVTKY 1407 C+G F+ I I L + ++ + Sbjct: 447 CIGMRFALIMIKLAMVEILQSF 468
>Q8TAV3:CP2W1_HUMAN Cytochrome P450 2W1 - Homo sapiens (Human)| Length = 490 Score = 89.4 bits (220), Expect = 4e-17 Identities = 110/440 (25%), Positives = 183/440 (41%), Gaps = 25/440 (5%) Frame = +1 Query: 166 RLPPGSMGLPLVGET--FQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAE 339 R PPG LPLVG + + SL + +RYGPVF L Q VV E Sbjct: 30 RWPPGPRPLPLVGNLHLLRLSQQDRSL------MELSERYGPVFTVHLGRQKTVVLTGFE 83 Query: 340 VNRFIFQQEGKLFRSWYPDTANNIFGK------ESIASYDGSFHKYVRSFASRLFGLDSL 501 + G+ P + + S A + + VR+ S G + + Sbjct: 84 AVKEALAGPGQELADRPPIAIFQLIQRGGGIFFSSGARWRAARQFTVRALHSLGVGREPV 143 Query: 502 RDVLLAEMDCNVTDSLAAWAAEP--AIEVKDAVANMVFDLTAKKLIGFSPEKSRKLRKNF 675 D +L E+ C ++ L + P + A +N+ F L + + L Sbjct: 144 ADKILQELKC-LSGQLDGYRGRPFPLALLGWAPSNITFALLFGRRFDYRDPVFVSLLGLI 202 Query: 676 DAFF-----QGLVSFPLY-FPGTTFYR---CIQGRKNVQKVLKDLLKERLGAPEKRHGDF 828 D GL F +Y + G ++ + V+ +L+ LL+ R P GD Sbjct: 203 DEVMVLLGSPGLQLFNVYPWLGALLQLHRPVLRKIEEVRAILRTLLEAR--RPHVCPGDP 260 Query: 829 LDEVVDEL-QSGRG-----VIDEKFAVDLMAALLFASFATVSSSLTIAMKFLSGHPNVVE 990 + VD L Q G+G + E AV ++ A T S++L A + HP+V Sbjct: 261 VCSYVDALIQQGQGDDPEGLFAEANAVACTLDMVMAGTETTSATLQWAALLMGRHPDVQG 320 Query: 991 SLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAPGIFRKTLTDVQVK 1170 ++EE + +L G E+ +++ +T+ V +E+ R + P + R T D Q+ Sbjct: 321 RVQEELDRVL-----GPGRTPRLEDQQALPYTSAVLHEVQRFITLLPHVPRCTAADTQLG 375 Query: 1171 GYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGIRLCVG 1350 G+ +P G V+ +V L+ ++ P FNP + D + + F+PF G R+CVG Sbjct: 376 GFLLPKGTPVIPLLTSVLLDETQWQTPGQFNPGHFLDANGHFVKREAFLPFSAGRRVCVG 435 Query: 1351 AEFSRIQIALFLHTLVTKYR 1410 +R ++ L L+ +YR Sbjct: 436 ERLARTELFLLFAGLLQRYR 455
>Q2XNC9:CP2D6_PANPA Cytochrome P450 2D6 - Pan paniscus (Pygmy chimpanzee) (Bonobo)| Length = 497 Score = 89.4 bits (220), Expect = 4e-17 Identities = 108/482 (22%), Positives = 199/482 (41%), Gaps = 39/482 (8%) Frame = +1 Query: 166 RLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVV--SMDAE 339 R PPG + LP +G + P + Q +R+G VF L PVVV + A Sbjct: 32 RYPPGPLPLPGLGNLLHV----DFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAV 87 Query: 340 VNRFIFQQEGKLFRSWYPDTANNIFGKESIASYDGSFHKYVRSFASRLFGLDSLRDVLLA 519 + E R P T FG S + + R R F + +LR++ L Sbjct: 88 REALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWRE--QRRFSVSTLRNLGLG 145 Query: 520 EMDCN--VTDSLAAWAA----------EPAIEVKDAVANMVFDLTAKKLIGFSPEKSRKL 663 + VT+ A A P + AV+N++ LT + + + +L Sbjct: 146 KKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRL 205 Query: 664 R-------KNFDAFFQGL---VSFPLYFPGTTFYRCIQGRKNVQKVLKDLLKERLGA--P 807 K F + + V L+ P + ++ +K L +LL E P Sbjct: 206 LDLAQEGLKEESGFLREVLNAVPVLLHIPALAG-KVLRFQKAFLTQLDELLTEHRMTWDP 264 Query: 808 EKRHGDFLDEVVDELQSGRGVIDEKFAVD----LMAALLFASFATVSSSLTIAMKFLSGH 975 + D + + E++ +G + F + ++A L A T S++L + + H Sbjct: 265 AQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILH 324 Query: 976 PNVVESLKEEHEAIL---KKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAP-GIFR 1143 P+V +++E + ++ ++ E G ++ M +T V +E+ R ++ P G+ Sbjct: 325 PDVQRRVQQEIDDVIGQVRRPEMGDQA--------RMPYTTAVIHEVQRFGDIVPLGVTH 376 Query: 1144 KTLTDVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPF 1323 T D++V+G+ IP G + + +V + ++E P F+P + D + F+PF Sbjct: 377 MTSRDIEVQGFRIPKGTTLFTNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPF 436 Query: 1324 GGGIRLCVGAEFSRIQIALFLHTLVTKYRWKEIKGGEVQRISEIVF-----PEGYHIQII 1488 G R C+G +R+++ LF +L+ + + + G+ + VF P Y + + Sbjct: 437 SAGRRACLGEPLARMELFLFFTSLLQHFSF-SVPTGQPRPSHHGVFAFLVTPSPYELCAV 495 Query: 1489 PR 1494 PR Sbjct: 496 PR 497
>P11510:CP2CC_RAT Cytochrome P450 2C12, female-specific - Rattus norvegicus (Rat)| Length = 490 Score = 89.4 bits (220), Expect = 4e-17 Identities = 105/461 (22%), Positives = 185/461 (40%), Gaps = 30/461 (6%) Frame = +1 Query: 130 VYKWTNPACSTGRLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVG 309 +Y W P+ G+LPPG LP+ G Q D+ K YGPVF Sbjct: 17 LYLW-RPSPGRGKLPPGPTPLPIFGNFLQI----DMKDIRQSISNFSKTYGPVFTLYFGS 71 Query: 310 QPVVVSMDAEVNRFIFQQEGKLF--RSWYPDTANNIFGKESIASYDGSFHKYVRSFASRL 483 QP VV E + G+ F R P +F K + SF + A+R Sbjct: 72 QPTVVLHGYEAVKEALIDYGEEFSGRGRMP-----VFEKAT-KGLGISFSRGNVWRATRH 125 Query: 484 FGLDSLRDVLLAEMDCNV-TDSLAAWAA-----------EPAIEVKDAVANMVFDLTAKK 627 F +++LR + + + + A W +P + A N++ + + Sbjct: 126 FTVNTLRSLGMGKRTIEIKVQEEAEWLVMELKKTKGSPCDPKFIIGCAPCNVICSIIFQN 185 Query: 628 LIGFSPEKSRKLRKNFDAF--------FQGLVSFPL---YFPGTTFYRCIQGRKNVQKVL 774 + + L +N + + FQ +FP+ Y PG +L Sbjct: 186 RFDYKDKDFLSLIENVNEYIKIVSTPAFQVFNAFPILLDYCPGNHKTHSKHFAAIKSYLL 245 Query: 775 KDLLKERLGAPEKRHGDFLDEVVDELQSGRGVIDEKFAVDLMAALLFASF--ATVSSSLT 948 K + + DF+D + + G + + +A L+ F T +SSLT Sbjct: 246 KKIKEHEESLDVSNPRDFIDYFLIQRCQENGNQQMNYTQEHLAILVTNLFIGGTETSSLT 305 Query: 949 I--AMKFLSGHPNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSN 1122 + A+ L +P++ + ++EE ++ + + M +T + +E+ R + Sbjct: 306 LRFALLLLMKYPHITDKVQEEIGQVIGRHRSPCML-----DRIHMPYTNAMIHEVQRYID 360 Query: 1123 VAP-GIFRKTLTDVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKST 1299 +AP G+ + D + + Y IP G V+ S +V + F +P F+P + DE+ Sbjct: 361 LAPNGLLHEVTCDTKFRDYFIPKGTAVLTSLTSVLHARKEFPNPEMFDPGHFLDENGNFK 420 Query: 1300 MLKNFMPFGGGIRLCVGAEFSRIQIALFLHTLVTKYRWKEI 1422 FMPF G R CVG + +++ LFL T++ ++ K + Sbjct: 421 KSDYFMPFSAGKRKCVGEGLASMELFLFLTTILQNFKLKSL 461
>P12790:CP2B9_MOUSE Cytochrome P450 2B9 - Mus musculus (Mouse)| Length = 491 Score = 89.4 bits (220), Expect = 4e-17 Identities = 97/440 (22%), Positives = 187/440 (42%), Gaps = 25/440 (5%) Frame = +1 Query: 163 GRLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEV 342 G LPPG LPL+G Q + + + Q +++G VF L +PVVV + Sbjct: 28 GHLPPGPHPLPLLGNLLQMDRGG----LLKCFIQLQEKHGDVFTVHLGPRPVVVLCGTQT 83 Query: 343 NRFIFQQEGKLFRSWYPDTANNIFGKE-SIASYDGSFHKYVRSFA---SRLFGLD--SLR 504 R + F A + ++ I G K +R F+ + FG+ S+ Sbjct: 84 IREALVDHAEAFSGRGTIAAAQLVMQDYGIFFASGQRWKTLRRFSLATMKEFGMGKRSVE 143 Query: 505 DVLLAEMDCNVTD--SLAAWAAEPAIEVKDAVANMVFDLTAKKLIGFSPEKSRKLRKNFD 678 + + E C V + +P + AN++ + + ++ ++ L Sbjct: 144 ERIKEEAQCLVEELKKYQGVPLDPTFLFQCITANIICSIVFGERFDYTDDQFLHLLNLMY 203 Query: 679 AFFQGLVSFP-----------LYFPGTTFYRCIQGRKNVQKVLKDLLKERLGAPEKRHGD 825 F L SF YFPG + ++ + + + K + D Sbjct: 204 KIFSLLSSFSGQMFELFSGFLKYFPGVHRQIVKKQQELLDYIAHSVEKHKATLDPSAPRD 263 Query: 826 FLDEVVDELQSGRGVIDEKFA-VDLMAALL---FASFATVSSSLTIAMKFLSGHPNVVES 993 ++D + ++ + + +F +LM ++L F T S++L + + +P+V E Sbjct: 264 YIDTYLLRMEKEKSNHNTEFHHQNLMMSVLSLFFVGTETTSATLHYGVLLMLKYPHVTEK 323 Query: 994 LKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAP-GIFRKTLTDVQVK 1170 +++E + ++ G+ T ++ M +T V +EI R S++ P G+ K + D + Sbjct: 324 VQKEIDQVI-----GSHRLPTLDDRTKMPYTDAVIHEIQRFSDLVPIGLPHKVIKDTLFR 378 Query: 1171 GYTIPAGWLVM-ISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGIRLCV 1347 GY +P V + A+H +P+ FE P FNP ++ D + + F+PF G R+C+ Sbjct: 379 GYLLPKNTEVYPVLSSALH-DPQYFEQPDKFNPEQFLDANGALKKCEAFLPFSTGKRICL 437 Query: 1348 GAEFSRIQIALFLHTLVTKY 1407 G +R ++ +F T++ + Sbjct: 438 GESIARNELFIFFTTILQNF 457
>Q8WNE1:CP2F5_GORGO Cytochrome P450 2F5 - Gorilla gorilla gorilla (Lowland gorilla)| Length = 491 Score = 89.0 bits (219), Expect = 6e-17 Identities = 99/441 (22%), Positives = 187/441 (42%), Gaps = 26/441 (5%) Frame = +1 Query: 163 GRLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEV 342 G+LPPG LPL+G S D+ + K YG ++ L + VVV + Sbjct: 28 GKLPPGPRPLPLLGNLLLL----RSQDMLTSLTKLSKEYGSMYTVHLGPRRVVVLSGYQA 83 Query: 343 NRFIFQQEGKLF--RSWYPDTANNIFGKESIASYDGSFHKYVRSFASRLF-----GLDSL 501 + +G+ F R +P N G IA +G K +R F+ ++ G S+ Sbjct: 84 VKEALVDQGEEFSGRRDFPAFFNFTKGN-GIAFSNGDRWKVLRRFSIQILRNFGMGKRSI 142 Query: 502 RDVLLAEMDCNVTD--SLAAWAAEPAIEVKDAVANMVFDLTAKKLIGFSPEKSRKLRKNF 675 + +L E + + +P + +V+N++ + + E+ + ++ Sbjct: 143 EERILEEGSFLLAELRKTEGEPFDPTFVLSRSVSNIICSVLFGSRFDYDDERLLTIIRHI 202 Query: 676 DAFFQGLVS--------FPL---YFPGTTFYRCIQGRKNVQKVLKDLLKERLGAPEKRHG 822 + FQ + S FP + PG R Q K ++ ++ + + + + R Sbjct: 203 NDNFQIMSSPWGELYDIFPSLLDWVPGP-HQRIFQNFKCLRDLIAHSVHDHQASLDPRSP 261 Query: 823 -DFLDEVVDELQSGRGVIDEKFAVDLMAA----LLFASFATVSSSLTIAMKFLSGHPNVV 987 DF+D + ++ F +D + LLF TV ++L A L +P V Sbjct: 262 RDFIDCFLTKMAEENEDPLSHFHMDTLLMTTHNLLFGGTETVGTTLRYAFLALMKYPKVQ 321 Query: 988 ESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAP-GIFRKTLTDVQ 1164 ++EE + ++ + A ++ +M +T V +E+ R +++ P + + D Sbjct: 322 ARVQEEIDLVVGRARLPAL-----KDRAAMPYTDAVIHEVQRFADIIPMSLPHRVTRDTA 376 Query: 1165 VKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGIRLC 1344 +G+ IP G ++ VH +P F P FNP + D ++ FMPF G RLC Sbjct: 377 FRGFLIPKGTDIITLLNTVHYDPSQFLTPQEFNPEHFLDANQSFKKSPAFMPFSAGRRLC 436 Query: 1345 VGAEFSRIQIALFLHTLVTKY 1407 +G +R+++ L+L ++ + Sbjct: 437 LGESLARMELFLYLTAILQSF 457
>P12939:CP2DA_RAT Cytochrome P450 2D10 - Rattus norvegicus (Rat)| Length = 504 Score = 89.0 bits (219), Expect = 6e-17 Identities = 106/459 (23%), Positives = 193/459 (42%), Gaps = 29/459 (6%) Frame = +1 Query: 118 LAHCVYKWTNPACSTGRLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKT 297 L H +WT+ R PPG + P++G Q PS + YK + RYG VF Sbjct: 25 LMHRHQRWTS------RYPPGPVPWPVLGNLLQV---DPSNMPYSMYKLQ-HRYGDVFSL 74 Query: 298 SLVGQPVVVSMDAEVNRFIFQQEGKLFRSWYPDTANNIFGKES------IASYDGSFHKY 459 + +P+V+ + + + G+ P G + ASY + + Sbjct: 75 QMGWKPMVIVNRLKAVQEVLVTHGEDTADRPPVPIFKCLGVKPRSQGVVFASYGPEWREQ 134 Query: 460 VRSFASRL----FGLDSLRDVLLAEMD--CNVTDSLAAWAAEPAIEVKDAVANMVFDLT- 618 R S L G SL + + E C+ + + P + A+ N++ L Sbjct: 135 RRFSVSTLRTFGMGKKSLEEWVTKEAGHLCDAFTAQNGRSINPKAMLNKALCNVIASLIF 194 Query: 619 AKKLIGFSPEKSRKLRKNFDAFFQG-------LVSFP--LYFPGTTFYRCIQGRKNVQKV 771 A++ P R L ++ + L +FP L PG + QG+K Sbjct: 195 ARRFEYEDPYLIRMLTLVEESLIEVSGFIPEVLNTFPALLRIPGLAD-KVFQGQKTFMAF 253 Query: 772 LKDLLKERLGA--PEKRHGDFLDEVVDELQSGRGVIDEKFAVD----LMAALLFASFATV 933 L +LL E P + + D + E++ +G + F + ++ L A T Sbjct: 254 LDNLLAENRTTWDPAQPPRNLTDAFLAEVEKAKGNPESSFNDENLRMVVVDLFTAGMVTT 313 Query: 934 SSSLTIAMKFLSGHPNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISR 1113 +++LT A+ + +P+V +++E + ++ G + M +T V +E+ R Sbjct: 314 ATTLTWALLLMILYPDVQRRVQQEIDEVI-----GQVRCPEMTDQAHMPYTNAVIHEVQR 368 Query: 1114 VSNVAP-GIFRKTLTDVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESK 1290 ++AP + R T D++V+ + IP G ++I+ +V + ++E PL F+P + D Sbjct: 369 FGDIAPLNLPRITSCDIEVQDFVIPKGTTLIINLSSVLKDETVWEKPLRFHPEHFLDAQG 428 Query: 1291 KSTMLKNFMPFGGGIRLCVGAEFSRIQIALFLHTLVTKY 1407 + FMPF G R C+G +R+++ LF L+ + Sbjct: 429 NFVKHEAFMPFSAGRRACLGEPLARMELFLFFTCLLQHF 467
>Q2XNC8:CP2D6_PANTR Cytochrome P450 2D6 - Pan troglodytes (Chimpanzee)| Length = 497 Score = 89.0 bits (219), Expect = 6e-17 Identities = 107/482 (22%), Positives = 200/482 (41%), Gaps = 39/482 (8%) Frame = +1 Query: 166 RLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVV--SMDAE 339 R PPG + LP +G + P + Q +R+G VF L PVVV + A Sbjct: 32 RYPPGPLPLPGLGNLLHV----DFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAV 87 Query: 340 VNRFIFQQEGKLFRSWYPDTANNIFGKESIASYDGSFHKYVRSFASRLFGLDSLRDVLLA 519 + E R P T FG S + + R R F + +LR++ L Sbjct: 88 REALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWRE--QRRFSVSTLRNLGLG 145 Query: 520 EMDCN--VTDSLAAWAA----------EPAIEVKDAVANMVFDLTAKKLIGFSPEKSRKL 663 + VT+ A A P + AV+N++ LT + + + +L Sbjct: 146 KKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRL 205 Query: 664 R-------KNFDAFFQGLVS---FPLYFPGTTFYRCIQGRKNVQKVLKDLLKERLGA--P 807 K F + +++ L+ P + ++ +K L +LL E P Sbjct: 206 LDLAQEGLKEESGFLREVLNAIPVLLHIPALAG-KVLRFQKAFLTQLDELLTEHRMTWDP 264 Query: 808 EKRHGDFLDEVVDELQSGRGVIDEKFAVD----LMAALLFASFATVSSSLTIAMKFLSGH 975 + D + + E++ +G + F + ++A L A T S++L + + H Sbjct: 265 AQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGIVTTSTTLAWGLLLMILH 324 Query: 976 PNVVESLKEEHEAIL---KKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAP-GIFR 1143 P+V +++E + ++ ++ E G ++ M +T V +E+ R ++ P G+ Sbjct: 325 PDVQRRVQQEIDDVIGQVRRPEMGDQA--------RMPYTTAVIHEVQRFGDIVPLGVTH 376 Query: 1144 KTLTDVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPF 1323 T D++V+G+ IP G + + +V + ++E P F+P + D + F+PF Sbjct: 377 MTSRDIEVQGFRIPKGTTLFTNLSSVLKDKAVWEKPFRFHPEHFLDAQGHFVKPEAFLPF 436 Query: 1324 GGGIRLCVGAEFSRIQIALFLHTLVTKYRWKEIKGGEVQRISEIVF-----PEGYHIQII 1488 G R C+G +R+++ LF +L+ + + + G+ + VF P Y + + Sbjct: 437 SAGRRACLGEPLARMELFLFFTSLLQHFSF-SVPTGQPRPSHHGVFAFLVTPSPYELCAV 495 Query: 1489 PR 1494 PR Sbjct: 496 PR 497
>Q6XVG2:CP254_MOUSE Cytochrome P450 2C54 - Mus musculus (Mouse)| Length = 490 Score = 89.0 bits (219), Expect = 6e-17 Identities = 107/451 (23%), Positives = 185/451 (41%), Gaps = 31/451 (6%) Frame = +1 Query: 163 GRLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEV 342 G+LPPG LP++G Q D+ + + YGPV+ L +P VV E Sbjct: 27 GKLPPGPTPLPIIGNILQI----DVKDICQSFTNLSRVYGPVYTLYLGRKPTVVLHGYEA 82 Query: 343 NRFIFQQEGKLF--RSWYP--DTANNIFGKESIASYDGSFHKYVRSFASRL-----FGLD 495 + G +F R P D A N G I +GS K R F+ G Sbjct: 83 VKEALVDHGDVFAGRGRLPVFDKATNGMG---IGFSNGSVWKNTRHFSLMTLRNLGMGKR 139 Query: 496 SLRDVLLAEMDCNVTD--SLAAWAAEPAIEVKDAVANMVFDLTAKKLIGFSPEKSRKLRK 669 S+ D + E C V + +P + A N++ + + + L + Sbjct: 140 SIEDRVQEEARCLVEELRKTNGSPCDPTFILGCAPCNVICSIIFQDRFDYKDRDFLNLLE 199 Query: 670 NFD--------AFFQGLVSFPL---YFPGT--TFYRCIQGRKN--VQKVLKDLLKERLGA 804 D + Q +FP Y PG+ F++ KN ++K+ + KE L Sbjct: 200 KLDEISKILSTPWLQVCNTFPALLDYCPGSHNQFFKNYAYIKNFLLEKIREH--KESLDV 257 Query: 805 PEKRHGDFLDE--VVDELQSGRGVIDEKF--AVDLMAALLFASFATVSSSLTIAMKFLSG 972 R DF+D + + + F + L ++S++L A+ L Sbjct: 258 TIPR--DFIDYFLIKGAQEDDNHPLKNNFEHLAITVTDLFIGGTESMSTTLRYALLLLLK 315 Query: 973 HPNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAPGIFRKTL 1152 +P+V ++EE E ++ K ++ M +T + +E+ R ++ P + Sbjct: 316 YPHVTAKVQEEIEHVIGKHRRPC-----MQDRSHMPYTNAMIHEVQRFIDLVPNNLPHEV 370 Query: 1153 T-DVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGG 1329 T D++ + Y IP G V+ S +V + + F +P F+P + DE+ K FMPF Sbjct: 371 TCDIKFRNYFIPKGTTVITSLSSVLRDSKEFPNPEKFDPGHFLDENGKFKKSDYFMPFST 430 Query: 1330 GIRLCVGAEFSRIQIALFLHTLVTKYRWKEI 1422 G R+C G +R+++ LFL +++ + K + Sbjct: 431 GKRICAGEGLARMELFLFLTSILQNFNLKPL 461
>Q64406:CP3AF_CAVPO Cytochrome P450 3A15 - Cavia porcellus (Guinea pig)| Length = 503 Score = 88.6 bits (218), Expect = 8e-17 Identities = 99/447 (22%), Positives = 193/447 (43%), Gaps = 26/447 (5%) Frame = +1 Query: 175 PGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEVNRFI 354 PG LPL G + K S D+ K+YG ++ QPV+ + ++ + + Sbjct: 39 PGPKPLPLFGNVLSYRKGMWSFDIEC-----RKKYGNMWGLYDGPQPVLAITEPDMIKAV 93 Query: 355 FQQEGKLFRSWYPDTANNIFGKESIASYDGSFHKYVRSFASRLFGLDSLRDV--LLAEMD 528 +E + F K+S++ + K +R+ S F L+++ ++ + Sbjct: 94 LVKECYSVFTNRRSLVPVGFMKKSVSLSEDEEWKRIRTQLSPNFTSGKLKEMFPIIKQYG 153 Query: 529 CNVTDSLAAWAAE-PAIEVKDAVANMVFDLTAKKLIGFSPE-----------KSRKLRKN 672 + +L A + +++K+ D+ G + + K+ KL + Sbjct: 154 DVLVKNLRQEAEKGKPVQLKEIFGAYGMDIIIATAFGVNVDSLNNPHDPFVSKANKLFR- 212 Query: 673 FDAFFQGLVSFPLYFPGTTFYRCIQ-------GRKNVQKVLKDLLKERLGAPEKRHGDFL 831 FD L+S ++ T Y + K K +K + L + +K+ +FL Sbjct: 213 FDFLSPFLLSTVMFPFLTQLYEMLSISIFPRDSLKFFTKFVKKTKENHLESNKKQRVNFL 272 Query: 832 DEVVD-----ELQSGRGVIDEKFAVDLMAALLFASFATVSSSLTIAMKFLSGHPNVVESL 996 +++ + +S + + D + + +FA + T SS+L+ M L+ HP+V + L Sbjct: 273 QMMLNSQNFKDTESHKALSDVEILAQSII-FIFAGYETSSSTLSCIMYSLATHPDVQKKL 331 Query: 997 KEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAPGIFRKTLTDVQVKGY 1176 +E + L K+ T++ M + V NE R+ VA I R + D ++ G Sbjct: 332 HQEIDKTLPN-----KAFPTYDVMMEMEYLDMVVNETLRLYPVANRIERMSKKDFEINGM 386 Query: 1177 TIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGIRLCVGAE 1356 + P G LVMI A+H + + + +P F P R+ ++K++ +MPFG G R C+G Sbjct: 387 SFPKGTLVMIPSFALHRDSKYWPEPDEFRPERFSKKNKENIDPYIYMPFGNGPRNCIGRR 446 Query: 1357 FSRIQIALFLHTLVTKYRWKEIKGGEV 1437 + + + L L L+ + + K ++ Sbjct: 447 MALMNLKLALIRLLQNFSFYPCKETQI 473
>P33266:CP2E1_MACFA Cytochrome P450 2E1 - Macaca fascicularis (Crab eating macaque)| (Cynomolgus monkey) Length = 449 Score = 88.6 bits (218), Expect = 8e-17 Identities = 83/333 (24%), Positives = 143/333 (42%), Gaps = 23/333 (6%) Frame = +1 Query: 565 EPAIEVKDAVANMVFDLTAKKLIGFSPEKSRKLRKNFDAFFQGLVS--FPLY--FPGTTF 732 +P + A N++ D+ +K ++ EK +L F+ FQGL LY FP Sbjct: 123 DPTFLIGCAPCNVIADILFRKRFDYNDEKFLRLMYLFNENFQGLSCPWLQLYNNFPSLLH 182 Query: 733 YRCIQGRKNVQKVLKDLLKERLGAPEKRHGDFLDE---------VVDELQSGRGVIDEKF 885 Y RK ++ V + +KE + K H LD ++ E++ + + + Sbjct: 183 YLPGSHRKVMKNVAE--IKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLY 240 Query: 886 AVD----LMAALLFASFATVSSSLTIAMKFLSGHPNVVESLKEEHEAILKKREEGAKSGI 1053 +D +A L FA T S++L + L +P + E L EE + ++ G Sbjct: 241 TMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVI-----GPSRIP 295 Query: 1054 TWEEYKSMTFTAQVTNEISRVSNVAPGIFRKTLT-DVQVKGYTIPAGWLVMISPMAVHLN 1230 ++ + M + V +EI R + P T D +GY IP G +++ + +V + Sbjct: 296 AIKDRQEMPYMHAVVHEIQRFITLVPSNLPHEATRDTIFRGYIIPKGTVIVPTLDSVLYH 355 Query: 1231 PELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGIRLCVGAEFSRIQIALFLHTLVTKYR 1410 + F DP F P DES K F PF G R+C G +R+++ L L ++ + Sbjct: 356 NQEFPDPEKFKPEHLVDESGKFKYSDYFKPFSAGKRVCAGEGLARMELFLLLSAILQHFN 415 Query: 1411 WKEIKGGEVQRISEI-----VFPEGYHIQIIPR 1494 K + + IS + P + + +IPR Sbjct: 416 LKPLVDPKDIDISPVNIGFGCIPPRFKLCVIPR 448
>Q9YH64:CP1A1_PLAFE Cytochrome P450 1A1 - Platichthys flesus (European flounder)| Length = 521 Score = 88.6 bits (218), Expect = 8e-17 Identities = 127/499 (25%), Positives = 208/499 (41%), Gaps = 46/499 (9%) Frame = +1 Query: 94 LAAVVAGWLAHCVYKWTNPACSTGRLP-PGSMGLPLVGETFQF-FKPSPSLDVPAFYKQR 267 L A+ L + + K+ G L PG LP++G KP SL Sbjct: 18 LVAMTTMCLVYLILKFFQTEIPEGLLRLPGPKPLPIIGNVLGLGSKPYLSLT------DM 71 Query: 268 LKRYGPVFKTSLVGQPVVVSMDAEVNRFIFQQEGKLFRSWYPDTANNIF---GKESIASY 438 KRYG VF+ + +PVVV +E R ++G F PD + F GK S Sbjct: 72 SKRYGHVFQIQIGMRPVVVLSGSETVRQALIKQGDDFAG-RPDLYSFRFINAGKSLAFST 130 Query: 439 DGS---------FHKYVRSFASRLFGLDSLRDVLLAEMDCNVTDSL---------AAWAA 564 D + + +RSF S L G +L E C + L A + Sbjct: 131 DQAGVWRARRKLAYSALRSF-SNLEGTTPEYSCVLEEHICKEGEYLIKQLNTVMKADGSF 189 Query: 565 EPAIEVKDAVANMV--------FDLTAKKLIGF---SPEKSRKLRKNFDAFFQGLVSFPL 711 +P + +VAN++ +D ++L+G S E R + A F ++ Sbjct: 190 DPFRHIVVSVANVICGMCFGRRYDHDDQELVGLVTLSDEFGRVVGSGNPADFIPILQ--- 246 Query: 712 YFPGTTFYRCIQGRKNVQKVLKDLLKERLGAPEKRH-GDFLDEVVDELQ-------SGRG 867 Y P ++ + ++ ++ E +K + D D ++D + S Sbjct: 247 YLPSAAMKNFLRINSRFTEFVQKIVTEHYTTFDKDNIRDITDSLIDHCEDRKLDENSNVQ 306 Query: 868 VIDEKFAVDLMAALLFASFATVSSSLTIAMKFLSGHPNVVESLKEEHEAILKKREEGAKS 1047 + DEK V ++ L A F TVS++L+ ++ +L HP + E L +E E + G Sbjct: 307 MSDEKI-VGIVNDLFGAGFDTVSTALSWSVMYLVAHPEIQERLYQEIED-----KVGLDR 360 Query: 1048 GITWEEYKSMTFTAQVTNEISRVSNVAP-GIFRKTLTDVQVKGYTIPAGWLVMISPMAVH 1224 + ++ F EI R S+ P I T D + GY IP V I+ ++ Sbjct: 361 MPLLSDKPNLPFLEAFILEILRHSSFLPFTIPHCTTKDTSLNGYFIPKDTCVFINQWQIN 420 Query: 1225 LNPELFEDPLTFNPWRW--QDESKKSTM-LKNFMPFGGGIRLCVGAEFSRIQIALFLHTL 1395 +PEL++DP +FNP R+ D S+ + + + M FG G R C+G +R ++ LFL + Sbjct: 421 HDPELWKDPSSFNPDRFLSADGSEVNKLDGEKVMAFGMGKRRCIGEVIARNEVYLFLAII 480 Query: 1396 VTKYRWKEIKGGEVQRISE 1452 + K + I G ++ E Sbjct: 481 IQKLHFLPIPGEKLDMTPE 499
>Q9SAE3:C71BS_ARATH Cytochrome P450 71B28 - Arabidopsis thaliana (Mouse-ear cress)| Length = 490 Score = 88.6 bits (218), Expect = 8e-17 Identities = 109/453 (24%), Positives = 186/453 (41%), Gaps = 34/453 (7%) Frame = +1 Query: 157 STGRLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDA 336 S +LPPG LP++G Q + P + ++YGP+ PVVV Sbjct: 24 SKWKLPPGPKKLPIIGNLHQRRELHPRNS-----RNLSEKYGPIVFLRYGFVPVVVISSK 78 Query: 337 EVNRFIFQQEGKLFRSWYPDTANNI-----FGKESIASYDGSFHKYVRSFASRLFG---L 492 E + + S P+T F A Y + + LF L Sbjct: 79 EAAEEVLKTHDLECCS-RPETVGTRAISYNFKDIGFAPYGEDWRTMRKLSVVELFSSKKL 137 Query: 493 DSLRDVLLAEMDCNVTDSLAAWAAEPAIEVKDAVANMVFDLTAKKLIGFS---------- 642 S R + E D V + + ++ + +V + + IGF Sbjct: 138 QSFRYIREEENDLCVKKLSDLASRRSLVNLEKTLFTLVGSIVCR--IGFGINLRECEFVD 195 Query: 643 -------PEKSRKLRKN--FDAFFQGLVSFPLYFPGTTFYRCIQGRKNVQKVLKDLLKER 795 KS + +N F FF GL+ + + + R + V +++L + Sbjct: 196 EDSIDDLVHKSEDVIRNSIFSDFFPGLMGRLIEWIFSERKRLNRLYSEVDTFFQNILDDH 255 Query: 796 LGAPEKRHGDFLDEVVDELQSGRGVIDE-KFAVD----LMAALLFASFATVSSSLTIAMK 960 L P + D +D ++D ++ D KF D +++ + A T S++L AM Sbjct: 256 L-KPGRESSDIIDVMIDMMKKQEKEGDSFKFTTDHLKGMISDIFLAGVGTSSTTLIWAMT 314 Query: 961 FLSGHPNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAPGIF 1140 L +P V++ +++E L ++E IT E+ + + + EI R+ AP + Sbjct: 315 ELIRNPRVMKKVQDEIRTTLGDKKER----ITEEDLNQLHYFKLMVKEIFRLHPAAPLLL 370 Query: 1141 -RKTLTDVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLK-NF 1314 R+TL+ V+++GY IPA +MI+ A+ +P+L+ +P FNP R+ D S L Sbjct: 371 PRETLSHVKIQGYDIPAKTQIMINAYAIARDPKLWTNPDEFNPDRFLDSSIDYRGLNFEL 430 Query: 1315 MPFGGGIRLCVGAEFSRIQIALFLHTLVTKYRW 1413 +PFG G R+C G + L L L+ + W Sbjct: 431 LPFGSGRRICPGMTMGIAIVELGLLNLLYFFDW 463
>Q9QYG6:CP2DR_MESAU Cytochrome P450 2D27 - Mesocricetus auratus (Golden hamster)| Length = 500 Score = 88.2 bits (217), Expect = 1e-16 Identities = 107/447 (23%), Positives = 186/447 (41%), Gaps = 33/447 (7%) Frame = +1 Query: 166 RLPPGSMGLPLVGETFQF-FKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEV 342 R PPG M LP +G Q F+ P + YK R +RYG VF + +PVVV + Sbjct: 35 RYPPGPMPLPGLGNLLQVDFEHMPY----SLYKFR-QRYGDVFSLQMAWKPVVVINGLKA 89 Query: 343 NRFIFQQEGKLFRSWYPDTANNI--FGKES----IASYDGSFHKYVRSFASRL----FGL 492 R + G+ P N FG S A Y + + R S + G Sbjct: 90 VREVLVNCGEDTADRPPVPIFNHVGFGHNSQGVAFARYGPQWREQRRFCVSTMRDFGVGK 149 Query: 493 DSLRDVLLAEMD--CNVTDSLAAWAAEPAIEVKDAVANMVFDLTAKKLIGFSPEKSRKLR 666 SL + E C+ A P + +V N++ L + L Sbjct: 150 KSLEQWVTEEAGHLCDAFTQEAGHPFNPTTLLNKSVCNVISSLIYAHRFDYEDPFFNSLL 209 Query: 667 KNFDAFF--------QGLVSFPLYF-----PGTTFYRCIQGRKNVQKVLKDLLKERLGAP 807 K F + L + P+ PG F + ++ K+L + + P Sbjct: 210 KMLQESFGEDTGFIAEVLNAVPVLLRIPGLPGKAFPKLTAFMDSLYKMLIE--HKTTWDP 267 Query: 808 EKRHGDFLDEVVDELQSGRGVIDEKFAVD----LMAALLFASFATVSSSLTIAMKFLSGH 975 + D + E++ +G + F + ++A + A T S++L+ A+ + H Sbjct: 268 AQPPRGLTDAFLAEVEKAKGRPESSFNDENLRMVVADMFIAGMVTTSTTLSWALLLMILH 327 Query: 976 PNVVESLKEEHEAILK--KREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAP-GIFRK 1146 P+V +++E + ++ +R E A + M +T V +E+ R ++AP I Sbjct: 328 PDVQSRVQQEIDDVIGQVRRPEMA-------DQARMPYTNAVIHEVQRFGDIAPVNIPHM 380 Query: 1147 TLTDVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFG 1326 T DV+V+G+ IP G ++ + +V + ++E PL F+P + D + + FMPF Sbjct: 381 TSHDVEVQGFLIPKGTTLIPNLSSVLKDETVWEKPLHFHPEHFLDAQGRFVKHEAFMPFS 440 Query: 1327 GGIRLCVGAEFSRIQIALFLHTLVTKY 1407 G R C+G +R+++ LF L+ ++ Sbjct: 441 AGRRACLGEPLARMELFLFFTCLLQRF 467
>P10633:CP2D1_RAT Cytochrome P450 2D1 - Rattus norvegicus (Rat)| Length = 504 Score = 88.2 bits (217), Expect = 1e-16 Identities = 100/459 (21%), Positives = 192/459 (41%), Gaps = 29/459 (6%) Frame = +1 Query: 118 LAHCVYKWTNPACSTGRLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKT 297 L H ++WT+ R PPG + P++G Q ++P + RYG VF Sbjct: 25 LMHRRHRWTS------RYPPGPVPWPVLGNLLQV----DLSNMPYSLYKLQHRYGDVFSL 74 Query: 298 SLVGQPVVVSMDAEVNRFIFQQEGKLFRSWYPDTANNIFGKES------IASYDGSFHKY 459 +P+V+ + + + G+ P G + +ASY + + Sbjct: 75 QKGWKPMVIVNRLKAVQEVLVTHGEDTADRPPVPIFKCLGVKPRSQGVILASYGPEWREQ 134 Query: 460 VRSFASRL----FGLDSLRDVLLAEMD--CNVTDSLAAWAAEPAIEVKDAVANMVFDLTA 621 R S L G SL + + E C+ + A + P + A+ N++ L Sbjct: 135 RRFSVSTLRTFGMGKKSLEEWVTKEAGHLCDAFTAQAGQSINPKAMLNKALCNVIASLIF 194 Query: 622 KKLIGFSPEKSRKLRKNFDAFF--------QGLVSFP--LYFPGTTFYRCIQGRKNVQKV 771 + + ++ K + + L +FP L PG + QG+K + Sbjct: 195 ARRFEYEDPYLIRMVKLVEESLTEVSGFIPEVLNTFPALLRIPGLAD-KVFQGQKTFMAL 253 Query: 772 LKDLLKERLGA--PEKRHGDFLDEVVDELQSGRGVIDEKFAVD----LMAALLFASFATV 933 L +LL E P + + D + E++ +G + F + ++ L A T Sbjct: 254 LDNLLAENRTTWDPAQPPRNLTDAFLAEVEKAKGNPESSFNDENLRMVVVDLFTAGMVTT 313 Query: 934 SSSLTIAMKFLSGHPNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISR 1113 +++LT A+ + +P+V +++E + ++ G + M +T V +E+ R Sbjct: 314 ATTLTWALLLMILYPDVQRRVQQEIDEVI-----GQVRCPEMTDQAHMPYTNAVIHEVQR 368 Query: 1114 VSNVAP-GIFRKTLTDVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESK 1290 ++AP + R T D++V+ + IP G ++I+ +V + ++E P F+P + D Sbjct: 369 FGDIAPLNLPRFTSCDIEVQDFVIPKGTTLIINLSSVLKDETVWEKPHRFHPEHFLDAQG 428 Query: 1291 KSTMLKNFMPFGGGIRLCVGAEFSRIQIALFLHTLVTKY 1407 + FMPF G R C+G +R+++ LF L+ ++ Sbjct: 429 NFVKHEAFMPFSAGRRACLGEPLARMELFLFFTCLLQRF 467
>Q92110:CP1A1_ONCMY Cytochrome P450 1A1 - Oncorhynchus mykiss (Rainbow trout) (Salmo| gairdneri) Length = 522 Score = 88.2 bits (217), Expect = 1e-16 Identities = 122/490 (24%), Positives = 206/490 (42%), Gaps = 44/490 (8%) Frame = +1 Query: 91 GLAAVVAGWLAHCVYKWTNPACSTG-RLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQR 267 GL A+V L + + K+ + G + PG LP++G + + +P L + A + Sbjct: 17 GLVAIVTLCLVYMLMKYKHTEIPEGLKRLPGPKPLPIIGNVLEVYN-NPHLSLTAMSE-- 73 Query: 268 LKRYGPVFKTSLVGQPVVVSMDAEVNRFIFQQEGKLFRSWYPDTANNIF---GKESIASY 438 RYG VF+ + +PVVV E R ++G+ F PD + F GK S Sbjct: 74 --RYGSVFQIQIGMRPVVVLSGNETVRQALIKQGEDFAG-RPDLYSFKFINDGKSLAFST 130 Query: 439 DGS---------FHKYVRSFASRLFGLDSLRDVLLAEMDCNVTDSLA---------AWAA 564 D + +RSFA+ L G L E C + L + + Sbjct: 131 DKAGVWRARRKLAMSALRSFAT-LEGTTPEYSCALEEHVCKEGEYLVKQLTSVMDVSGSF 189 Query: 565 EPAIEVKDAVANMVFDLTAKKLIGFSPEKSRKLRKNFDAFFQGLVS------FPL--YFP 720 +P + +VAN++ + + ++ L D F Q + S P+ Y P Sbjct: 190 DPFRHIVVSVANVICGMCFGRRYSHDDQELLGLVNMSDEFGQVVGSGNPADFIPILRYLP 249 Query: 721 GTTFYRCIQGRKNVQKVLKDLLKERLGAPEKRH-GDFLDEVVDELQSGR-------GVID 876 T R + ++ ++ E + +K + D D ++D + + V D Sbjct: 250 NRTMKRFMDINDRFNNFVQKIVSEHYESYDKDNIRDITDSLIDHCEDRKLDENANIQVSD 309 Query: 877 EKFAVDLMAALLFASFATVSSSLTIAMKFLSGHPNVVESLKEEHEAILKKREEGAKSGIT 1056 EK V ++ L A F T+S++L+ A+ +L +P + E L +E K + G Sbjct: 310 EKI-VGIVNDLFGAGFDTISTALSWAVVYLVAYPEIQERLHQE-----LKEKVGMIRTPR 363 Query: 1057 WEEYKSMTFTAQVTNEISRVSNVAP-GIFRKTLTDVQVKGYTIPAGWLVMISPMAVHLNP 1233 + ++ EI R S+ P I T+ D + GY IP V I+ V+ +P Sbjct: 364 LSDKINLPLLEAFILEIFRHSSFLPFTIPHCTIKDTSLNGYFIPKDTCVFINQWQVNHDP 423 Query: 1234 ELFEDPLTFNPWRWQDESKKSTML-----KNFMPFGGGIRLCVGAEFSRIQIALFLHTLV 1398 EL+++P +FNP R+ S T L + + FG R C+G R ++ LFL L+ Sbjct: 424 ELWKEPSSFNPDRFL--SADGTELNKLEGEKVLVFGMDKRRCIGEAIGRNEVYLFLAILL 481 Query: 1399 TKYRWKEIKG 1428 + R++E G Sbjct: 482 QRLRFQEKPG 491
>Q9V770:C6A17_DROME Probable cytochrome P450 6a17 - Drosophila melanogaster (Fruit fly)| Length = 501 Score = 88.2 bits (217), Expect = 1e-16 Identities = 65/223 (29%), Positives = 110/223 (49%), Gaps = 7/223 (3%) Frame = +1 Query: 766 KVLKDLLKERLGAPEKRHGDFLDEVVDEL---QSGRGVIDEKFAVDLMAALLF--ASFAT 930 K++++ + RL EKR+ DF+D +++ QSG F L A +F A F T Sbjct: 250 KIVRETIDYRLRTKEKRN-DFMDSLIEMYKNEQSGNSEDGLTFNELLAQAFIFFVAGFET 308 Query: 931 VSSSLTIAMKFLSGHPNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEIS 1110 S+++ A+ L+ + +V + L+EE + K + T+E K M + QV E Sbjct: 309 SSTTMGFALYELARNQDVQDKLREEIGNVFGKHNKE----FTYEGIKEMKYLEQVVMETL 364 Query: 1111 RVSNVAPGIFRKTLTDVQVKG--YTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDE 1284 R V + R T TD + Y I G +V+I + +H +P+++ +P F P R+ DE Sbjct: 365 RKYPVLAHLTRMTDTDFSPEDPKYFIAKGTIVVIPALGIHYDPDIYPEPEIFKPERFTDE 424 Query: 1285 SKKSTMLKNFMPFGGGIRLCVGAEFSRIQIALFLHTLVTKYRW 1413 + ++PFG G R C+G F +Q + L L+ Y++ Sbjct: 425 EIAARPSCTWLPFGEGPRNCIGLRFGMMQTCVGLAYLIRGYKF 467
>P10613:CP51_CANAL Cytochrome P450 51 - Candida albicans (Yeast)| Length = 528 Score = 87.8 bits (216), Expect = 1e-16 Identities = 92/431 (21%), Positives = 182/431 (42%), Gaps = 44/431 (10%) Frame = +1 Query: 253 FYKQRLKRYGPVFKTSLVGQPVVVSMDAEVNRFIFQQE--GKLFRSWYPDTANNIFGKES 426 F++ ++YG VF L+G+ + V + + + F+F + Y +FGK Sbjct: 71 FFESCRQKYGDVFSFMLLGKIMTVYLGPKGHEFVFNAKLSDVSAEDAYKHLTTPVFGKGV 130 Query: 427 IASYDGSFHKYVRSFASRLFGLDSLRDVLLAEMDCNVTDSLAAWAAEPAIEVKD---AVA 597 I S + FA DS + + + + L + + + ++K+ VA Sbjct: 131 IYDCPNSRLMEQKKFAKFALTTDSFKRYVPKIRE----EILNYFVTDESFKLKEKTHGVA 186 Query: 598 NMVFDLTAKKLIGFSPEKSR---KLRKNFDAFFQGLVS------FPLYF-----PGTTFY 735 N++ T ++ F+ +S ++R+ FD F L S P+ F P ++ Sbjct: 187 NVM--KTQPEITIFTASRSLFGDEMRRIFDRSFAQLYSDLDKGFTPINFVFPNLPLPHYW 244 Query: 736 RCIQGRKNVQKV-LKDLLKERLGAPEKRHGDFLDEVV--DELQSGRGVIDEKFAVDLMAA 906 R +K + +K++ R + D +D ++ + G + D++ A +L+ Sbjct: 245 RRDAAQKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIA-NLLIG 303 Query: 907 LLFASFATVSSSLTIAMKFLSGHPNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFT 1086 +L T +S+ + L P++ + + +E +LK++ G + +T+E+ + + Sbjct: 304 ILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKG-GDLNDLTYEDLQKLPSV 362 Query: 1087 AQVTNEISRVSNVAPGIFRKTLTDVQVK--GYTIPAGWLVMISPMAVHLNPELFEDPLTF 1260 E R+ IFRK +++ Y +P G V++SP H + F++P F Sbjct: 363 NNTIKETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDF 422 Query: 1261 NPWRWQDESKKSTMLK--------------------NFMPFGGGIRLCVGAEFSRIQIAL 1380 +P RW + K+ + ++PFGGG C+G +F+ +Q+ Sbjct: 423 DPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGT 482 Query: 1381 FLHTLVTKYRW 1413 L T V RW Sbjct: 483 ILTTFVYNLRW 493
>Q9D816:CP255_MOUSE Cytochrome P450 2C55 - Mus musculus (Mouse)| Length = 490 Score = 87.8 bits (216), Expect = 1e-16 Identities = 109/478 (22%), Positives = 196/478 (41%), Gaps = 34/478 (7%) Frame = +1 Query: 163 GRLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEV 342 G+LPPG P++G Q + S F K YGPVF +P VV E Sbjct: 27 GKLPPGPTPFPIIGNILQIDIKNISKSFNYFSKV----YGPVFTLYFGSKPTVVVHGYEA 82 Query: 343 NRFIFQQEGKLF--RSWYP--DTANNIFGKESIASYDGSFHKYVRSFAS---RLFGLD-- 495 + G+ F R + + NN G + +G+ K +R F+ R FG+ Sbjct: 83 VKEALDDLGEEFSGRGSFQIFERINNDLG---VIFSNGTKWKELRRFSIMTLRSFGMGKR 139 Query: 496 SLRDVLLAEMDCNVTDSLAAWAA--EPAIEVKDAVANMVFDLTAKKLIGFSPEKSRKLRK 669 S+ D + E C V + A + +P + A +N++ + + EK L + Sbjct: 140 SIEDRIQEEASCLVEELRKANGSLCDPTFILSCAPSNVICSVIFHNRFDYKDEKFLNLME 199 Query: 670 NFDAFFQGLVS--FPLYFPGTTFYRCIQGRKNVQKVLKDL--LKERLGAPEKRHG----- 822 + F+ L S +Y T + G N KV+K+ +K + K H Sbjct: 200 RLNENFKILNSPWMQVYNALPTLINYLPGSHN--KVIKNFTEIKSYILGRVKEHQETLDM 257 Query: 823 ----DFLDEVVDELQSGRGVIDEKFAVDLMAALLFASFATVSSSLTIAMKF----LSGHP 978 DF+D + +++ + +F ++ + A + F + + I +++ L H Sbjct: 258 DNPRDFIDCFLIKMEQEKHNPHSEFTIESLMATVTDIFVAGTETTNITLRYGLLLLLKHT 317 Query: 979 NVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAPGIFRKTLT- 1155 V ++ E + ++ G ++ M +T + +EI R ++ P T Sbjct: 318 EVTAKVQAEIDHVI-----GRHRSPCMQDRTRMPYTDAMVHEIQRYIDLIPNNVPHAATC 372 Query: 1156 DVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGI 1335 +V+ + Y IP G ++ S +V + + F +P F+P + DE+ FMPF G Sbjct: 373 NVRFRSYFIPKGTELVTSLTSVLHDDKEFPNPEVFDPGHFLDENGNFKKSDYFMPFSIGK 432 Query: 1336 RLCVGAEFSRIQIALFLHTLVTKYRWKEIKGGEVQRISEIV-----FPEGYHIQIIPR 1494 R+CVG +R ++ L L T++ + K + + + + P Y + IPR Sbjct: 433 RMCVGEALARTELFLILTTILQNFNLKSLVDTKDIDTTPVANTFGRVPPSYQLYFIPR 490
>P56654:CP237_MOUSE Cytochrome P450 2C37 - Mus musculus (Mouse)| Length = 490 Score = 87.8 bits (216), Expect = 1e-16 Identities = 108/453 (23%), Positives = 183/453 (40%), Gaps = 33/453 (7%) Frame = +1 Query: 163 GRLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEV 342 G+LPPG LP++G Q D+ + K YGPV+ L +P VV E Sbjct: 27 GKLPPGPTPLPIIGNILQI----DVKDICQSFTNLSKVYGPVYTLYLGRKPTVVLHGYEA 82 Query: 343 NRFIFQQEGKLF--RSWYP--DTANNIFGKESIASYDGSFHKYVRSFASRLF-----GLD 495 + G+ F R +P D A N G +A G+ K R F+ G Sbjct: 83 VKEALVDHGEEFAGRGRFPVFDKATNGMG---LAFSKGNVWKNTRRFSLMTLRNLGMGKR 139 Query: 496 SLRDVLLAEMDCNVTD--SLAAWAAEPAIEVKDAVANMVFDLTAKKLIGFSPEKSRKLRK 669 S+ D + E C V + +P + A N++ + + + L + Sbjct: 140 SIEDRVQEEARCLVEELRKTNGSPCDPTFILGCAPCNVICSIIFQDRFDYKDRDFLNLME 199 Query: 670 NFDAFFQGLVSFPLY----FPGTTFYRCIQGRKNVQK---VLKDLLKERLGAPEKRHGDF 828 + + L S L +P Y C K K +K+ L E++ K H + Sbjct: 200 KLNEITKILSSPWLQICNTYPALLDY-CPGSHKQFFKNYACIKNFLLEKI----KEHEES 254 Query: 829 LD-----EVVDELQSGRGVID---------EKFAVDLMAALLFASFATVSSSLTIAMKFL 966 LD + +D G D E A+ + L A T S++L A+ L Sbjct: 255 LDVTIPRDFIDYFLINGGQEDGNQPLQNRLEHLAITV-TDLFSAGTETTSTTLRYALLLL 313 Query: 967 SGHPNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAPGIFRK 1146 +P+V +++E E ++ K ++ M +T + +E+ R ++ P Sbjct: 314 LKYPHVTAKVQKEIEHVIGKHRSPCM-----QDRSRMPYTDAMIHEVQRFIDLIPNSLPH 368 Query: 1147 TLT-DVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPF 1323 +T D++ + Y IP G V+ S +V + F +P F+P + D + K FMPF Sbjct: 369 EVTCDIKFRNYFIPKGTTVITSLSSVLHDSTEFPNPEVFDPGHFLDGNGKFKKSDYFMPF 428 Query: 1324 GGGIRLCVGAEFSRIQIALFLHTLVTKYRWKEI 1422 G R+C G +R+++ LFL +++ + K + Sbjct: 429 STGKRICAGEGLARMELFLFLTSILQSFNLKPL 461
>P49602:CP51_USTMA Cytochrome P450 51 - Ustilago maydis (Smut fungus)| Length = 561 Score = 87.4 bits (215), Expect = 2e-16 Identities = 103/497 (20%), Positives = 207/497 (41%), Gaps = 62/497 (12%) Frame = +1 Query: 190 LPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEVNRFIFQQEG 369 +P++G + +D F+ + ++YG VF L+G+ + V++ + + +F + Sbjct: 67 VPVIGSAIYY-----GIDPYKFFFECREKYGDVFTFVLLGRKITVALGPKGSNLVFNAKH 121 Query: 370 KLFRSW--YPDTANNIFGKESIASYDGSFHKYVRSFASRLFGLDSLRDVLLAEMDCNVTD 543 + + Y +FGKE + + + F +++ R V + ++ V + Sbjct: 122 QQVTAEDAYTHLTTPVFGKEVVYDVPNAVFMEQKKFVKVGLSIENFR-VYVPQIVDEVRE 180 Query: 544 SLAAWAAEPAIEVKDAVANMVFD-------LTAKKLIGFSPEKSRKLRKNFDAFFQGLVS 702 + + A A++ + + +F LTA + + E + L K+F + L S Sbjct: 181 YIKSDARFSALKTRKTITVDIFQAMSELIILTASRTLQ-GKEVRQGLDKSFAQLYHDLDS 239 Query: 703 --FPLYF-----PGTTFYRCIQGRKNVQKVLKDLLKERLGAPEKR-------HGDFLDEV 840 P+ F P + ++ + +K + + +D++ +R A D + + Sbjct: 240 GFTPINFVIPNLPLPSNFKRDRAQKKMSQFYQDIVAKRRAAGASTSADDASGENDMIAAL 299 Query: 841 VDE-LQSGRGVIDEKFAVDLMAALLFASFATVSSSLTIAMKFLSGHPNVVESLKEEHEAI 1017 +++ ++GR + + A +M ALL A T S++ + A L+ P ++E L EE + Sbjct: 300 IEQKYKNGRALSGVEIA-HMMIALLMAGQHTSSATSSWAFLRLASRPEIIEELYEEQLNV 358 Query: 1018 LKKREEGAKSGITWEEYK-SMTFTAQVTNEISRVSNVAPGIFRKTLTDVQVKG------- 1173 G + + +E K S+ V E R+ I R +D+ V Sbjct: 359 YSDGHGGLRE-LDYETQKTSVPLLDAVVKETLRLHPPLHSIMRYVKSDLAVPPTLSSPTS 417 Query: 1174 --------YTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKN------ 1311 Y IP G +M +P ++P++++ F+P RW D + + M + Sbjct: 418 TKSEPDAHYVIPKGHYIMAAPGVSQVDPQIWKSSDQFDPHRWLDATTAAAMQDSGEDKQD 477 Query: 1312 -------------FMPFGGGIRLCVGAEFSRIQIALFLHTLVTKYRWK-EIKGGEVQRIS 1449 ++PFG G C+G +F+ +QI + L T V ++W + K + S Sbjct: 478 FGFGMISTGANSPYLPFGAGRHRCIGEQFAYLQIGVILATFVRIFKWHLDSKFPDPDYQS 537 Query: 1450 EIVFP--EGYHIQIIPR 1494 +V P G I + PR Sbjct: 538 MVVLPSKNGCAIVLTPR 554
>Q759W0:CP51_ASHGO Cytochrome P450 51 - Ashbya gossypii (Yeast) (Eremothecium gossypii)| Length = 529 Score = 87.4 bits (215), Expect = 2e-16 Identities = 95/425 (22%), Positives = 172/425 (40%), Gaps = 38/425 (8%) Frame = +1 Query: 253 FYKQRLKRYGPVFKTSLVGQPVVVSMDAEVNRFIFQQE--GKLFRSWYPDTANNIFGKES 426 F+ + ++YG VF L+G+ + V + + + FI + Y +FG+ Sbjct: 77 FFGKCQQKYGDVFAFMLLGRVMTVYLGTKGHEFILNAKLAEVSAEEAYTKLTTPVFGEGV 136 Query: 427 IASYDGSFHKYV--RSFASRLFGLDSLRDVLLAEMDCNVTDSLAAWAAEPAIEVKDAVAN 600 + YD H+ + + F ++ R + MD V L E V N Sbjct: 137 V--YDCPNHRLMEQKKFCKNALSTEAFRRYVPMVMD-EVRKYLRTSKHFMMNERSSGVVN 193 Query: 601 MVFDLTAKKLIGFSPEKS---RKLRKNFDAFFQGLVS------FPLYF-----PGTTFYR 738 ++ T ++ F+ +S ++ DA F L + PL F P + R Sbjct: 194 VME--TQPEMTIFTASRSLLGAEMHSMLDADFAYLYADLDKGFTPLNFVFRDLPLDNYRR 251 Query: 739 CIQGRKNVQKVLKDLLKERLGAPEKRHGDFLDEVVDELQSGRGV--IDEKFAVDLMAALL 912 ++ + +++ R + + D +D ++ Q GV D++ A L+ L+ Sbjct: 252 RDNAQRTISSTYMKVIERRRKNNDVQDRDLIDALMTSAQYKDGVKMTDQQIANLLIGVLM 311 Query: 913 FASFATVSSSLTIAMKFLSGHPNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQ 1092 + ++S + + L+ P++ E L EE +L +G +T+E + M Q Sbjct: 312 GGQHTSAATSAWVLLH-LAERPDIQEELYEEQMRVL----DGGAKELTYELLQEMPLLNQ 366 Query: 1093 VTNEISRVSNVAPGIFRKTLTDVQVKG--YTIPAGWLVMISPMAVHLNPELFEDPLTFNP 1266 V E R+ + +FRK D+ V Y IP V+ SP HL+ E F + FNP Sbjct: 367 VIKETLRMHHPLHSLFRKVTRDMPVPNTSYVIPKDHYVLASPGFCHLSEEYFPNAKEFNP 426 Query: 1267 WRWQDESKKST----------------MLKNFMPFGGGIRLCVGAEFSRIQIALFLHTLV 1398 RW +++ S + ++PFGGG C+G F+ +Q+ +V Sbjct: 427 HRWDNDAASSVSTGEKVDYGFGAISKGVSSPYLPFGGGRHRCIGEGFAYMQLGTIFSVVV 486 Query: 1399 TKYRW 1413 +W Sbjct: 487 RSMKW 491
>Q92039:CP1A1_CHACA Cytochrome P450 1A1 - Chaetodon capistratus (Four-eye butterflyfish)| Length = 521 Score = 87.4 bits (215), Expect = 2e-16 Identities = 122/489 (24%), Positives = 204/489 (41%), Gaps = 44/489 (8%) Frame = +1 Query: 94 LAAVVAGWLAHCVYKWTNPACSTG-RLPPGSMGLPLVGETFQF-FKPSPSLDVPAFYKQR 267 L A+ A L + + K+ G R PG LP++G + KP SL + Sbjct: 18 LVALTAVCLVYLILKFFRTEIPAGLRQLPGPKPLPIIGNVLEVGSKPHLSLTAMS----- 72 Query: 268 LKRYGPVFKTSLVGQPVVVSMDAEVNRFIFQQEGKLFRSWYPDTANNIF---GKESIASY 438 KRYG VF+ + +PVVV +E R ++G F S PD + F GK S Sbjct: 73 -KRYGDVFQIQIGMRPVVVLSGSETVRQALIKQGDEF-SGRPDLYSFTFINDGKSLAFST 130 Query: 439 D-----GSFHKY----VRSFASRLFGLDSLRDVLLAEMDCNVTDSL---------AAWAA 564 D G+ K +RSF S L G +L E C + L A + Sbjct: 131 DQAGVCGACRKLAYSALRSF-STLDGTTPEYSCMLEEHICKEGECLINQLNTVMKADGSF 189 Query: 565 EPAIEVKDAVANMVFDLTAKKLIGFSPEKSRKLRKNFDAFFQ--------GLVSFPLYFP 720 +P + +VAN++ + + + + +L D F Q ++ + P Sbjct: 190 DPFRHIVVSVANVICGMCFGRRYDHNDQDLLRLVNLSDEFGQVAGSGNPADFINILRFLP 249 Query: 721 GTTFYRCIQGRKNVQKVLKDLLKERLGAPEKRH-GDFLDEVVDELQSGR-------GVID 876 TT + + + +K ++ E +K + D D ++D + + + D Sbjct: 250 STTMKKFMTINADFNTFVKKIVGEHYATFDKNNIRDITDSLIDHCEDRKLDENCNVQMSD 309 Query: 877 EKFAVDLMAALLFASFATVSSSLTIAMKFLSGHPNVVESLKEEHEAILKKREEGAKSGIT 1056 EK V ++ L A F TVS++L+ ++ +L +P++ E L +E K G Sbjct: 310 EKI-VGIVNDLFGAGFDTVSTALSWSVMYLVAYPDIQERLFQEI-----KDNVGLDRTPL 363 Query: 1057 WEEYKSMTFTAQVTNEISRVSNVAP-GIFRKTLTDVQVKGYTIPAGWLVMISPMAVHLNP 1233 + + + E+ R S+ P I + D + GY IP V I+ ++ +P Sbjct: 364 LSDRSKVPYLEAFILELFRHSSFLPFTIPHCSAKDTSLNGYFIPKDTCVFINQWQINRDP 423 Query: 1234 ELFEDPLTFNPWRWQD----ESKKSTMLKNFMPFGGGIRLCVGAEFSRIQIALFLHTLVT 1401 EL++DP +FNP R+ E K K M FG G R C+G +R ++ L L+ Sbjct: 424 ELWKDPSSFNPDRFLSCNGTEVNKQEGEK-VMVFGMGKRRCIGEVIARNEVYRGLAILIQ 482 Query: 1402 KYRWKEIKG 1428 + ++ E+ G Sbjct: 483 RLQFHEMPG 491
>P79152:CP3AJ_CAPAE Cytochrome P450 3A19 - Capra aegagrus (Wild goat)| Length = 218 Score = 87.0 bits (214), Expect = 2e-16 Identities = 52/176 (29%), Positives = 89/176 (50%) Frame = +1 Query: 910 LFASFATVSSSLTIAMKFLSGHPNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTA 1089 +F + T S+SL+ + L+ HP+V + L+EE +A K+ T++ M + Sbjct: 14 IFGGYETTSTSLSFIIYELATHPDVQQKLQEEIDATFPN-----KAPPTYDALVQMEYLD 68 Query: 1090 QVTNEISRVSNVAPGIFRKTLTDVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPW 1269 V NE R+ +A + R DV++ G +IP G VM+ +H NPE + +P F P Sbjct: 69 MVVNETLRMFPIAGRLERLCKKDVEIHGVSIPKGTTVMVPLFVLHNNPEFWPEPEEFRPE 128 Query: 1270 RWQDESKKSTMLKNFMPFGGGIRLCVGAEFSRIQIALFLHTLVTKYRWKEIKGGEV 1437 R+ ++K ++PFG G R CVG F+ + I L L ++ + + K ++ Sbjct: 129 RFSKKNKDGINPYVYLPFGTGPRNCVGMRFALMNIKLALVRILQNFSFIPCKETQI 184
>Q92116:CP1A1_STECH Cytochrome P450 1A1 - Stenotomus chrysops (Scup)| Length = 521 Score = 87.0 bits (214), Expect = 2e-16 Identities = 119/488 (24%), Positives = 200/488 (40%), Gaps = 42/488 (8%) Frame = +1 Query: 91 GLAAVVAGWLAHCVYKWTNPACSTGRLP-PGSMGLPLVGETFQFFKPSPSLDVPAFYKQR 267 GL A++ LA+ + + G L PG LP++G + + +P L + A K Sbjct: 17 GLVAMITMCLAYLILRLFRTEIPEGLLQLPGPKPLPIIGNVLEVGR-NPYLSLTAMSK-- 73 Query: 268 LKRYGPVFKTSLVGQPVVVSMDAEVNRFIFQQEGKLFRSWYPDTANNIF---GKESIASY 438 RYG VF+ + +PVVV +E R ++G F PD + F GK S Sbjct: 74 --RYGDVFQIQIGMRPVVVLSGSETVRQALIKQGDXFAG-RPDLYSFRFINDGKSLAFST 130 Query: 439 DGS---------FHKYVRSFASRLFGLDSLRDVLLAEMDCNVTDSL---------AAWAA 564 D + + +RSFA+ L G L E + L A + Sbjct: 131 DQAGVWRARRKLAYSALRSFAT-LEGTTPEYSCALEEHVSKEAEYLVKQLHTVMEADGSF 189 Query: 565 EPAIEVKDAVANMVFDLTAKKLIGFSPEKSRKLRKNFDAFFQGLVS------FPL--YFP 720 +P + +VAN++ + + + ++ L D F Q + S P+ Y P Sbjct: 190 DPFRHIVVSVANVICGMCFGRRYDHNHQELLNLVNLSDEFGQVVASGNPADFIPILQYLP 249 Query: 721 GTTFYRCIQGRKNVQKVLKDLLKERLGAPEKRH-GDFLDEVVDELQ-------SGRGVID 876 TT + + ++ ++ E +K + D D ++D + S + D Sbjct: 250 STTMKKFLNINDRFNTFVQKIVSEHYTTFDKDNIRDITDSLIDHCEDRKLDENSNVQMSD 309 Query: 877 EKFAVDLMAALLFASFATVSSSLTIAMKFLSGHPNVVESLKEEHEAILKKREEGAKSGIT 1056 EK V ++ L A F T+S++L+ ++ +L +P + E L +E + G Sbjct: 310 EKI-VGIVNDLFGAGFDTISTALSWSVMYLVAYPEIQERLYQEMNETV-----GPDRTPC 363 Query: 1057 WEEYKSMTFTAQVTNEISRVSNVAP-GIFRKTLTDVQVKGYTIPAGWLVMISPMAVHLNP 1233 + + F E R S+ P I T D + GY IP V I+ ++ + Sbjct: 364 LSDKPKLPFLEAFILETFRHSSFLPFTIPHCTSKDTSLNGYFIPKDTCVFINQWQINHDA 423 Query: 1234 ELFEDPLTFNPWRWQDESKKSTML---KNFMPFGGGIRLCVGAEFSRIQIALFLHTLVTK 1404 EL++DP +FNP R+ + + M FG G R C+G +R ++ LFL LV Sbjct: 424 ELWKDPSSFNPDRFLNADGTEVNKLEGEKMMVFGMGKRRCIGEVIARSEVFLFLAILVQN 483 Query: 1405 YRWKEIKG 1428 R+ + G Sbjct: 484 LRFHSMPG 491
>Q27593:CP6A8_DROME Cytochrome P450 6a8 - Drosophila melanogaster (Fruit fly)| Length = 506 Score = 86.7 bits (213), Expect = 3e-16 Identities = 59/234 (25%), Positives = 113/234 (48%), Gaps = 15/234 (6%) Frame = +1 Query: 757 NVQKVLKDLLKERLGAPEKRH---GDFLDEVVD-------ELQSGRGVIDEKFAVDLMAA 906 ++Q+ ++ E + EK H DF+D +++ L++G V L A Sbjct: 245 HIQEFYSRIVTETVAVREKEHIKRNDFMDMLIELKNQKEMTLENGDVVRGLTMEEVLAQA 304 Query: 907 LLF--ASFATVSSSLTIAMKFLSGHPNVVESLKEEHEAILKKREEGAKSGITWEEYKSMT 1080 +F A F T SS++ A+ L+ +P++ + ++ E E ++++ ++ T+E K + Sbjct: 305 FVFFIAGFETSSSTMGFALYELAKNPDIQDKVRAEVEEVIEQHDQN----FTYECTKDLK 360 Query: 1081 FTAQVTNEISRVSNVAPGIFRKTLTDVQVKG---YTIPAGWLVMISPMAVHLNPELFEDP 1251 + QV +E R+ + P + R V G + I AG V+I A+H +P ++ +P Sbjct: 361 YLNQVLDETLRLYTIVPNLDRMAAKRYVVPGHPNFVIEAGQSVIIPSSAIHHDPSIYPEP 420 Query: 1252 LTFNPWRWQDESKKSTMLKNFMPFGGGIRLCVGAEFSRIQIALFLHTLVTKYRW 1413 F P R+ E ++PFG G R C+G F ++Q + L L+ +++ Sbjct: 421 FEFRPERFSPEESAGRPSVAWLPFGDGPRNCIGLRFGQMQARIGLALLIRNFKF 474
>Q9V776:CP317_DROME Probable cytochrome P450 317a1 - Drosophila melanogaster (Fruit fly)| Length = 518 Score = 86.3 bits (212), Expect = 4e-16 Identities = 65/232 (28%), Positives = 113/232 (48%), Gaps = 16/232 (6%) Frame = +1 Query: 766 KVLKDLLKER--LGAPEKRHGDFLDEVVD----ELQSGRGVIDEKFAVDLMAAL------ 909 K+L ++++R G P+K D+L ++D E + + D++ L L Sbjct: 260 KLLTSIVEQRETSGKPQK---DYLQLLIDVKALEFITYQYEADKELGAHLQNELAAHADV 316 Query: 910 -LFASFATVSSSLTIAMKFLSGHPNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFT 1086 L A + +++L+ + L+ HP + ++EE +KK E IT E KS++F Sbjct: 317 FLKAGYEQTANTLSYVLYELALHPELQVRVREE----VKKAIERHDGHITHEGIKSLSFM 372 Query: 1087 AQVTNEISRVSNVAPGIFRKTLTDVQVKG---YTIPAGWLVMISPMAVHLNPELFEDPLT 1257 QV NE R+ + P I R+TL D V Y + ++I A+H +P+++ DP Sbjct: 373 GQVINETLRMHPITPYILRRTLNDYAVPDHPKYILVKELFLIIPTHAIHHDPDIYPDPEE 432 Query: 1258 FNPWRWQDESKKSTMLKNFMPFGGGIRLCVGAEFSRIQIALFLHTLVTKYRW 1413 F P RW + FG G R C+G +F+++Q+ L L L+++Y + Sbjct: 433 FKPDRWSGPRDSLQEQGTWFGFGVGARSCIGIQFAQLQLRLALALLLSEYEF 484
>Q96SQ9:CP2S1_HUMAN Cytochrome P450 2S1 - Homo sapiens (Human)| Length = 504 Score = 86.3 bits (212), Expect = 4e-16 Identities = 108/455 (23%), Positives = 192/455 (42%), Gaps = 40/455 (8%) Frame = +1 Query: 163 GRLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRL---KRYGPVFKTSL-VGQPVVVSM 330 G LPPG LPL+G Q +P A Y + K+YGPVF L +PVVV + Sbjct: 30 GHLPPGPTPLPLLGNLLQL-RPG------ALYSGLMRLSKKYGPVFTIYLGPWRPVVVLV 82 Query: 331 DAEVNRFIFQQEGKLFRSWYPDTANNIFGKESIASYDGSFHKYVRSFAS-------RLFG 489 E R + + F G+ ++A +G+F + F++ R F Sbjct: 83 GQEAVREALGGQAEEFS-----------GRGTVAMLEGTFDGHGVFFSNGERWRQLRKFT 131 Query: 490 LDSLRDV----------LLAEMDCNVT--DSLAAWAAEPAIEVKDAVANMVFDLTAKKLI 633 + +LRD+ + AE C V +P++ + A +N+V L Sbjct: 132 MLALRDLGMGKREGEELIQAEARCLVETFQGTEGRPFDPSLLLAQATSNVVCSLLFGLRF 191 Query: 634 GFSPEKSRKLRKNFDAFFQGLVSF--PLYFPGTTFYRCIQG-RKNVQKVLKDLLKERLGA 804 + ++ + + + G+ S Y + F R + G K + + L + Sbjct: 192 SYEDKEFQAVVRAAGGTLLGVSSQGGQTYEMFSWFLRPLPGPHKQLLHHVSTLAAFTVRQ 251 Query: 805 PEKRHGD-------------FLDEVVDELQSGRGVIDEKFAVDLMAALLFASFATVSSSL 945 ++ G+ FL ++ E Q+ K + + LLFA TVS+++ Sbjct: 252 VQQHQGNLDASGPARDLVDAFLLKMAQEEQNPGTEFTNKNMLMTVIYLLFAGTMTVSTTV 311 Query: 946 TIAMKFLSGHPNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNV 1125 + L +P+V + ++EE RE GA + + + +T V +E R+ + Sbjct: 312 GYTLLLLMKYPHVQKWVREE-----LNRELGAGQAPSLGDRTRLPYTDAVLHEAQRLLAL 366 Query: 1126 AP-GIFRKTLTDVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTM 1302 P GI R + + +GYT+P G V ++ +P +F+ P FNP R+ D + Sbjct: 367 VPMGIPRTLMRTTRFRGYTLPQGTEVFPLLGSILHDPNIFKHPEEFNPDRFLDADGRFRK 426 Query: 1303 LKNFMPFGGGIRLCVGAEFSRIQIALFLHTLVTKY 1407 + F+PF G R+C+G ++ ++ LF T++ + Sbjct: 427 HEAFLPFSLGKRVCLGEGLAKAELFLFFTTILQAF 461
>P51581:CP2E1_MESAU Cytochrome P450 2E1 - Mesocricetus auratus (Golden hamster)| Length = 493 Score = 86.3 bits (212), Expect = 4e-16 Identities = 103/477 (21%), Positives = 199/477 (41%), Gaps = 31/477 (6%) Frame = +1 Query: 157 STGRLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDA 336 S+ LPPG LP++G FQ ++P + +R+GPVF L + +VV Sbjct: 28 SSWNLPPGPFPLPILGNIFQL----DLKNIPKSLTKLAERFGPVFTLHLGSKRIVVLHGY 83 Query: 337 EVNRFIFQQEGKLFRSWYPDTANNIFGKESIASYDGSFHKYVRSFA---SRLFGLDSLRD 507 + + + F + + I +G K VR F+ R +G+ + Sbjct: 84 KAVKEVLLNHKNEFSGRGDIPVFQEYMNKGIIFNNGPTWKDVRRFSLSILRDYGMGKQGN 143 Query: 508 VLLAEMDCNV----TDSLAAWAAEPAIEVKDAVANMVFDLTAKKLIGFSPEKSRKLRKNF 675 + + + +P V A N++ D+ K ++ + +L F Sbjct: 144 EARIQREAHFLMEELKKTNGQPFDPTFLVGCAPFNVISDILFHKRFDYNDKTCLRLMSLF 203 Query: 676 DAFFQGLVSFP---LYFPGTTFYRCIQGRKNVQKVLKDL--LKERLGAPEKRHGDFLD-- 834 + F L+S P Y + R + G + +K++K+ +++ A K H LD Sbjct: 204 NENFY-LLSTPWIQAYNNFENYLRYLPG--SHRKIMKNASEIRQYTLAKAKEHLQSLDSS 260 Query: 835 ---EVVD----ELQSGRGVIDEKFAVD----LMAALLFASFATVSSSLTIAMKFLSGHPN 981 +V D E++ + + + ++ +A L FA T S++L + L +P Sbjct: 261 CPRDVTDCLLIEMEKEKDSQEPMYTMENISVTLADLFFAGTETTSTTLRYGLLILMKYPE 320 Query: 982 VVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISR-VSNVAPGIFRKTLTD 1158 V E L EE + ++ G +++ M + V +EI R +S + + + D Sbjct: 321 VEEKLHEEIDRVI-----GPSRVPVFKDRLEMPYMDAVVHEIQRFISLIPSNLPHEATRD 375 Query: 1159 VQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGIR 1338 +GY IP G +V+ + ++ + + F DP F P + +E+ K +F F G R Sbjct: 376 TMFRGYVIPKGTVVIPTLDSLLYDSQEFPDPEKFKPEHFLNENGKFKYSDHFKAFSAGKR 435 Query: 1339 LCVGAEFSRIQIALFLHTLVTKYRWKEIKGGEVQRISEIVF-----PEGYHIQIIPR 1494 +CVG +R+++ L L ++ + K + + ++ + P + + +IPR Sbjct: 436 VCVGEGLARMELFLLLTAILQHFNLKSLVDPKDIDLNPVTIGFGCVPPEFKLCVIPR 492
>P11714:CP2D9_MOUSE Cytochrome P450 2D9 - Mus musculus (Mouse)| Length = 504 Score = 86.3 bits (212), Expect = 4e-16 Identities = 104/493 (21%), Positives = 206/493 (41%), Gaps = 33/493 (6%) Frame = +1 Query: 118 LAHCVYKWTNPACSTGRLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKT 297 L H +WT+ R PPG + P++G Q + +P + RYG VF Sbjct: 25 LTHQRQRWTS------RYPPGPVPWPVLGNLLQVDLGN----MPYSLYKLQNRYGDVFSL 74 Query: 298 SLVGQPVVVSMDAEVNRFIFQQEGKLFRSWYPDTANNIFGKES------IASYDGSFHKY 459 + +P+VV + + + G+ P G + +A Y + + Sbjct: 75 QMAWKPMVVINGLKAMKEMLLTCGEDTADRPPVPIFEYLGVKPGSQGVVLAPYGPEWREQ 134 Query: 460 VRSFASRL--FGLD--SLRDVLLAEMD--CNVTDSLAAWAAEPAIEVKDAVANMVFDLTA 621 R S L FGL SL D + E + C+ + A P + + N++ L Sbjct: 135 RRFSVSTLRNFGLGKKSLEDWVTKEANHLCDAFTAQAGQPINPNPMLNKSTCNVIASLIF 194 Query: 622 KKLIGFSPEKSRKLRKNFDAFF---QGLV-----SFPLYFPGTTFY-RCIQGRKNVQKVL 774 + + ++ K + GL+ +FP+ + +QG+K+ +L Sbjct: 195 ARRFEYEDPFLIRMLKVLEQSLTEVSGLIPEVLNAFPILLRIPRLADKALQGQKSFIAIL 254 Query: 775 KDLLKER------LGAPEKRHGDFLDEVVDELQSGRGVIDEKFAVDLMAALLFASFATVS 936 +LL E + AP FL ++ + +++ + ++ L A T S Sbjct: 255 DNLLTENRTTWDPVQAPRNLTDAFLAQIEKAKGNPESSFNDENLLMVVRDLFGAGMLTTS 314 Query: 937 SSLTIAMKFLSGHPNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRV 1116 ++L+ A+ + HP+V +++E + ++ G + M +T V +E+ R Sbjct: 315 TTLSWALMLMILHPDVQRRVQQEIDEVI-----GQVRHPEMADQAHMPYTNAVIHEVQRF 369 Query: 1117 SNVAP-GIFRKTLTDVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKK 1293 ++ P + R T D++V+ + IP G +++ + ++ + ++E PL F+P + D Sbjct: 370 GDIVPVNLPRITSHDIEVQDFLIPKGTILLPNMSSMLKDESVWEKPLRFHPEHFLDAQGH 429 Query: 1294 STMLKNFMPFGGGIRLCVGAEFSRIQIALFLHTLVTKYRWKEIKGGEVQRISE-----IV 1458 + FMPF G R C+G +R+++ LF L+ ++ + + G+ Q + +V Sbjct: 430 FVKPEAFMPFSAGRRSCLGEALARMELFLFFTCLLQRFSF-SVPDGQPQPSNSGVYGILV 488 Query: 1459 FPEGYHIQIIPRE 1497 P Y + + R+ Sbjct: 489 APSPYQLCAVVRD 501
>Q9V774:C6A21_DROME Probable cytochrome P450 6a21 - Drosophila melanogaster (Fruit fly)| Length = 504 Score = 86.3 bits (212), Expect = 4e-16 Identities = 61/235 (25%), Positives = 117/235 (49%), Gaps = 17/235 (7%) Frame = +1 Query: 760 VQKVLKDLLKERLGAPEK---RHGDFLDEVVD-------ELQSGRGVIDEKFAVDLMAAL 909 +++ +++E + E+ R DF+D+++D QSG V ++ +AA Sbjct: 245 IERFFMRIVRETVAFREQNNIRRNDFMDQLIDLKNKPLMVSQSGESV---NLTIEEIAAQ 301 Query: 910 LF----ASFATVSSSLTIAMKFLSGHPNVVESLKEEHEAILKKREEGAKSGITWEEYKSM 1077 F A F T S+++ A+ L+ + ++ +++E + +++K + +E K + Sbjct: 302 AFVFFAAGFETSSTTMGFALYELAQNQDIQNRVRKECQEVIEK----CNGELNYESMKDL 357 Query: 1078 TFTAQVTNEISRVSNVAPGIFRKTLTDVQVKG---YTIPAGWLVMISPMAVHLNPELFED 1248 + QV +E R+ V P + R+ L D +V G Y I G V+I A+H + +L+ + Sbjct: 358 VYLDQVVSETLRLYTVLPVLNRECLEDYEVPGHPKYVIKKGMPVLIPCGAMHRDEKLYAN 417 Query: 1249 PLTFNPWRWQDESKKSTMLKNFMPFGGGIRLCVGAEFSRIQIALFLHTLVTKYRW 1413 P TFNP + E K ++PFG G R C+G F ++Q + L L+ +++ Sbjct: 418 PNTFNPDNFSPERVKERDSVEWLPFGDGPRNCIGMRFGQMQARIGLALLIKDFKF 472
>O61387:CP6B7_HELAM Cytochrome P450 6B7 - Helicoverpa armigera (Cotton bollworm)| (Heliothis armigera) Length = 504 Score = 85.9 bits (211), Expect = 5e-16 Identities = 60/260 (23%), Positives = 126/260 (48%), Gaps = 15/260 (5%) Frame = +1 Query: 763 QKVLKDLLKERLGAPEKRHGDFLDEVVDELQSGR--------GVIDEKFAVDLMAALLFA 918 + ++ +++ +R G P R+ DF+D +++ Q G GV + +++ A F Sbjct: 243 KSLVDNIISQRNGKPAGRN-DFMDLILELRQMGEVTSNKYLDGVTSLEITDEVICAQAFV 301 Query: 919 SFATVSSSLTIAMKFLSGHPNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVT 1098 + + M +L ++ + ++ + A + + + + +T++ K M + +V Sbjct: 302 FYVAGYETSATTMSYLIYQLSLNQDVQNKLIAEVDEAIKASDGKVTYDTVKEMKYLNKVF 361 Query: 1099 NEISRVSNVAPGIFRKTLTDVQVKG--YTIPAGWLVMISPMAVHLNPELFEDPLTFNPWR 1272 +E R+ ++ + RK D Q+ G I +V+ISP +H +P+ +++P FNP R Sbjct: 362 DETLRMYSIVEPLQRKATRDYQIPGTDVVIEKDTMVLISPRGIHYDPKYYDNPKQFNPDR 421 Query: 1273 WQDESKKSTMLKNFMPFGGGIRLCVGAEFSRIQIALFLHTLVTKYRWKEIKGG----EVQ 1440 + E ++PFG G R C+G F R+Q L + +++K+R + K +V+ Sbjct: 422 FDAEEVGKRHPCAYLPFGLGQRNCIGMRFGRLQSLLCITKILSKFRIEPSKNTDRNLQVE 481 Query: 1441 RISEIVFPE-GYHIQIIPRE 1497 + P+ G + I+PR+ Sbjct: 482 PRRVTIGPKGGIRVNIVPRK 501
>Q4PJW3:CP51A_BOVIN Cytochrome P450 51A1 - Bos taurus (Bovine)| Length = 502 Score = 85.9 bits (211), Expect = 5e-16 Identities = 103/483 (21%), Positives = 199/483 (41%), Gaps = 25/483 (5%) Frame = +1 Query: 55 EGYSQVAFASLCGLAAVVAGWLAHCVYKWT------NPACSTG-RLPPGSMG-LPLVGET 210 + QV +L + + + VY + P TG + PP + +P +G Sbjct: 14 QAMEQVTGGNLASMLLIACAFTLSLVYLFRLAVGHLAPPLPTGAKSPPYIVSPIPFLGHA 73 Query: 211 FQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEVNRFIFQQEGKLFRSW- 387 F K SP F + ++YGPVF ++VG+ + +E +F + + + Sbjct: 74 IAFGK-SPI----EFLEDAYEKYGPVFSFTMVGKTFTYLLGSEAAALLFNSKNEDLNAEE 128 Query: 388 -YPDTANNIFGKESIASYDGSFHKYVRSFASRLFGLDSL---RDVLLAEMDCNVTDSLAA 555 Y +FGK +YD ++ GL+ + V + E + + + Sbjct: 129 VYSRLTTPVFGKG--VAYDVPNTVFLEQKKMLKSGLNIAHFRQHVSIIEKETK--EYFKS 184 Query: 556 WAAEPAIEVKDAVANMVFDLTA------KKLIGFSPEKSRKLRKNFDAFFQGLV-SFPLY 714 W + +A++ ++ LTA K++ EK +L + D F P + Sbjct: 185 WGESGEKNLFEALSELII-LTASHCLHGKEIRSQLNEKVAQLYADLDGGFSHAAWLLPGW 243 Query: 715 FPGTTFYRCIQGRKNVQKVLKDLLKERLGAPEKRHGDFLDEVVDEL-----QSGRGVIDE 879 P +F R + + ++ + +++R + G+ +D+++ L + GR + D+ Sbjct: 244 LPLPSFRRRDRAHREIKNIFYKAIQKR-----RESGEKIDDILQTLLESTYKDGRPLTDD 298 Query: 880 KFAVDLMAALLFASFATVSSSLTIAMKFLSGHPNVVESLKEEHEAILKKREEGAKSGITW 1059 + A L+ LL + ++S + FL+ + E E + + + +T+ Sbjct: 299 EVAGMLIGLLLAGQHTSSTTSAWMGF-FLARDKTLQEKCFLEQKTVCGEN----LPPLTY 353 Query: 1060 EEYKSMTFTAQVTNEISRVSNVAPGIFRKTLTDVQVKGYTIPAGWLVMISPMAVHLNPEL 1239 ++ K + + E R+ + R T + V GYTIP G V +SP + Sbjct: 354 DQLKDLNLLDRCIKETLRLRPPIMTMMRLAKTPLTVAGYTIPPGHQVCVSPTVNQRLKDS 413 Query: 1240 FEDPLTFNPWRWQDESKKSTMLKNFMPFGGGIRLCVGAEFSRIQIALFLHTLVTKYRWKE 1419 + + L FNP R+ ++S S ++PFG G C+G F+ +QI T++ Y + Sbjct: 414 WVERLDFNPDRYLEDSPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEFDL 473 Query: 1420 IKG 1428 I G Sbjct: 474 IDG 476
>Q02928:CP4AB_HUMAN Cytochrome P450 4A11 precursor - Homo sapiens (Human)| Length = 519 Score = 85.9 bits (211), Expect = 5e-16 Identities = 54/185 (29%), Positives = 92/185 (49%), Gaps = 1/185 (0%) Frame = +1 Query: 811 KRHGDFLDEVVDELQSGRGVIDEKFAVDLMAALLFASFATVSSSLTIAMKFLSGHPNVVE 990 KRH DFLD ++ ++ +K + +F T +S ++ + L+ HP E Sbjct: 286 KRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQE 345 Query: 991 SLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAPGIFRKTLTDVQVK 1170 +EE ++L G + ITW M +T E R+ PGI R+ T V Sbjct: 346 RCREEIHSLL-----GDGASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFP 400 Query: 1171 -GYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGIRLCV 1347 G ++P G +V++S +H NP+++ +P F+P+R+ S + + F+PF GG R C+ Sbjct: 401 DGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAPGSAQHS--HAFLPFSGGSRNCI 458 Query: 1348 GAEFS 1362 G +F+ Sbjct: 459 GKQFA 463
>P12791:CP2BA_MOUSE Cytochrome P450 2B10 - Mus musculus (Mouse)| Length = 500 Score = 85.9 bits (211), Expect = 5e-16 Identities = 111/474 (23%), Positives = 201/474 (42%), Gaps = 57/474 (12%) Frame = +1 Query: 157 STGRLPPGSMGLPLVGETFQFFKPSPSLDVPAFYK---QRLKRYGPVFKTSLVGQPVVVS 327 S G PPG LPL+G Q +D K Q ++YG VF L +PVV+ Sbjct: 26 SRGNFPPGPRPLPLLGNLLQ-------MDRGGLLKSLIQLREKYGDVFTVHLGPRPVVML 78 Query: 328 MDAEVNRFIFQQEGKLFRSWYPDTANNIFGKESIASYDGSFHKYVRSFAS-------RLF 486 + R + + F G+ ++A + +F +Y FA+ R F Sbjct: 79 CGTDTIREALVGQAEAFS-----------GRGTVAVVEPTFKEYGVIFANGERWKTLRRF 127 Query: 487 GLDSLRDV----------LLAEMDCNVTDSLAAWAA--EPAIEVKDAVANMVFDLTAKKL 630 L ++RD + E C V + + A +P + AN++ + + Sbjct: 128 SLATMRDFGMGKRSVEERIQEEAQCLVEELRKSQGAPLDPTFLFQCITANVICSIVFGER 187 Query: 631 IGFSPEKSRKLRKNFDAFFQGLVSFPL-----------YFPGTTFYRCIQGRKNVQKVLK 777 ++ + +L + F F + SF YFPG + + K L+ Sbjct: 188 FEYTDRQFLRLLELFYQTFSLISSFSSQMFELFSGFLKYFPGA--------HRQISKNLQ 239 Query: 778 DLLKERLGAPEKRHG---------DFLDEVVDELQSGRGVIDEKFA-VDLMAALLFASFA 927 +LL + +G +RH DF+D + ++ + + +F +LM ++L F Sbjct: 240 ELL-DYIGHSVERHKATLDPSVPRDFIDIYLLRMEKEKSNQNAEFHHQNLMMSVLSLFFV 298 Query: 928 -TVSSSLTIAMKFLS--GHPNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVT 1098 T +SS T+ FL +P+V E +++E + ++ G+ T ++ M ++ V Sbjct: 299 GTETSSTTLHYGFLLMLKYPHVTEKVQKEIDQVI-----GSHRLPTLDDRTKMPYSDAVI 353 Query: 1099 NEISRVSNVAP-GIFRKTLTDVQVKGYTIPAGWLVM-ISPMAVHLNPELFEDPLTFNPWR 1272 +EI R S++ P G+ + D +GY +P V I A+H +P+ FE P +FNP + Sbjct: 354 HEIQRFSDLIPIGVPHRVTKDTLFRGYLLPKNTEVYPILSSALH-DPQYFEQPDSFNPDQ 412 Query: 1273 WQDESKKSTMLKNFMPFGG---------GIRLCVGAEFSRIQIALFLHTLVTKY 1407 + D + + F+PF G R+C+G +R ++ LF +++ + Sbjct: 413 FLDANGALKKSEAFLPFSTGQIFDQKSVGKRICLGESIARSELFLFFTSILQNF 466
>P58049:C71BB_ARATH Cytochrome P450 71B11 - Arabidopsis thaliana (Mouse-ear cress)| Length = 496 Score = 85.5 bits (210), Expect = 6e-16 Identities = 60/235 (25%), Positives = 111/235 (47%), Gaps = 15/235 (6%) Frame = +1 Query: 832 DEVVD--------ELQSGRGVIDEKFAVDLMAALLFASFATVSSSLTIAMKFLSGHPNVV 987 D+++D E++ G + ++ +L A T + +T M +L +P V+ Sbjct: 261 DDIIDLLLKMERGEIELGEFQLTRDNTKGILFNILNAGIDTSAQVMTWVMTYLISNPRVM 320 Query: 988 ESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAPGIF-RKTLTDVQ 1164 + + E ++K +++ I E+ + + + V E RV + P + R+ DV+ Sbjct: 321 KKAQAEVREVIKNKDD-----IIEEDIERLEYLKMVVKETFRVLPLVPLLIPREASKDVK 375 Query: 1165 VKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLK-NFMPFGGGIRL 1341 + GY IP + ++ A+H NP +++DP F P R+ D L F+PFG G R+ Sbjct: 376 IGGYDIPKKTWIHVNIWAIHRNPNVWKDPEAFIPERFMDNQIDYKGLNFEFLPFGSGRRM 435 Query: 1342 CVGAEFSRIQIALFLHTLVTKYRWKEIKGGEVQRIS-----EIVFPEGYHIQIIP 1491 C G + L L L+ ++ WK +G EV+ + +V P+ +Q+IP Sbjct: 436 CPGIGMGMALVHLTLINLLYRFDWKLPEGMEVEDVDLEESYGLVCPKKVPLQLIP 490
>Q8SPK0:CP4AP_PIG Cytochrome P450 4A25 - Sus scrofa (Pig)| Length = 504 Score = 85.1 bits (209), Expect = 8e-16 Identities = 78/339 (23%), Positives = 146/339 (43%), Gaps = 30/339 (8%) Frame = +1 Query: 559 AAEPAIEVKDAVANMVFDLTAKKLIGFSPEKSRKLRKNFDAFFQGLVSFPLYFPGTT--- 729 A +P +E+ V+ M D K FS + S + + ++ Q + F T Sbjct: 172 AQDPRLEIVGPVSLMTLDTIMK--CAFSHQGSAQTDGDSHSYIQAIWDLKNLFSIRTKSA 229 Query: 730 ------FYRCI-QGRKN----------------VQKVLKDLLKERLGAPEKRHGDFLDEV 840 YR +GRKN ++K E +KRH DFLD + Sbjct: 230 FLQNDIIYRLSPEGRKNHRAARIAHQHTDRVIQLRKAQLQKQGEMENVRKKRHLDFLDIL 289 Query: 841 V-DELQSGRGVIDEKFAVDLMAALLFASFATVSSSLTIAMKFLSGHPNVVESLKEEHEAI 1017 + ++ G + D ++ +F T +S ++ + L+ HP + +EE + + Sbjct: 290 LLARMEKGNSLSDTDLRAEV-DTFMFEGHDTTASGISWILYALASHPEHQQRCREEIQGL 348 Query: 1018 LKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAPGIFRKTLTDVQVK-GYTIPAGW 1194 L G + ITW+ M +T E R+ PG+ R+ + G ++PAG Sbjct: 349 L-----GDGTSITWDHLDQMPYTTMCIKEALRLYPPVPGVSRELSKPITFPDGRSLPAGI 403 Query: 1195 LVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGIRLCVGAEFSRIQI 1374 ++ +S ++H NP+++ +P F+P R+ S + + FMPF GG R C+G +F+ ++ Sbjct: 404 ILSLSVYSLHHNPQVWPNPEEFDPSRFAPGSARHS--HAFMPFSGGSRNCIGKQFAMNEM 461 Query: 1375 ALFLHTLVTKYRWKEIKGGEVQRISEIVF--PEGYHIQI 1485 + + + ++ + I E+V G H+++ Sbjct: 462 KVAVALTLLRFELAPDPSRKPTVIPEVVLHSKNGIHLKL 500
>Q9VW43:CP305_DROME Probable cytochrome P450 305a1 - Drosophila melanogaster (Fruit fly)| Length = 504 Score = 85.1 bits (209), Expect = 8e-16 Identities = 116/481 (24%), Positives = 196/481 (40%), Gaps = 38/481 (7%) Frame = +1 Query: 79 ASLCGLAAVVAGWLAHCVYKWTNPACSTGRLPPGSMGLPLVGETFQFFKPSPSLDVPAFY 258 ++L L A++ G++ +Y + A PPG +P +G T QF K + ++ Sbjct: 2 SALIFLCAILIGFV---IYSLISSARRPKNFPPGPRFVPWLGNTLQFRKEASAVGGQHIL 58 Query: 259 KQRLKRYGPVFKTSLVG-----QPVVVSMDAEVNRFIFQQEGKLFRSWYPDT----ANNI 411 +R+ F++ LVG + VVV++ E+ + + QE +F PD + Sbjct: 59 ---FERWAKDFRSDLVGLKLGREYVVVALGHEMVKEVQLQE--VFEG-RPDNFFLRLRTM 112 Query: 412 FGKESIASYDGSFHKYVRSFASRL-----FGLDSLRD--VLLAEMDCNVTDSLAAWAAEP 570 ++ I DG R FA + +G + L AE + EP Sbjct: 113 GTRKGITCTDGQLWYEHRHFAMKQMRNVGYGRSQMEHHIELEAEELLGQLERTEEQPIEP 172 Query: 571 AIEVKDAVANMVFDLTAKKLIGFSPEKS--------RKLRKNFDAFFQGLVSFPLY---F 717 + +V N+++ L A K I + + + K FD L FP Sbjct: 173 VTWLAQSVLNVLWCLIAGKRIARQEDGTLRRLLDLMNRRSKLFDICGGLLAQFPWLRHVA 232 Query: 718 PGTTFYRCIQGRKN---------VQKVLKDLLKERLGAPEKRHGDFLDEVVDELQSGRG- 867 P T Y IQ +++ + L K+ A +L E+ D G Sbjct: 233 PDRTGYNLIQQLNTELYGFFMDTIEEHRRQLAKDPSPAESDLIYAYLQEMKDRSAGGESS 292 Query: 868 VIDEKFAVDLMAALLFASFATVSSSLTIAMKFLSGHPNVVESLKEEHEAILKKREEGAKS 1047 +E V + A T S+++ +A+ L+ P+V E L + A + A Sbjct: 293 TFNETQLVMTILDFFIAGSQTTSNTINLALMVLAMRPDVQEKLFSQVTASVAAASTDAFP 352 Query: 1048 GITWEEYKSMTFTAQVTNEISRVSNVAPGIF-RKTLTDVQVKGYTIPAGWLVMISPMAVH 1224 ++ E + + E+ R ++ P R+ L ++ GY IP ++IS +VH Sbjct: 353 HLSRRE--AFDYMDAFIMEVQRFFHITPITGPRRALWATKLGGYDIPKNATILISLRSVH 410 Query: 1225 LNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGIRLCVGAEFSRIQIALFLHTLVTK 1404 L+ E ++DPL F P R+ D + K + FMPFG G R C+G +R I FL +V Sbjct: 411 LDKEHWKDPLEFRPERFIDSAGKCFKDEYFMPFGMGRRRCLGDALARACIFSFLVRIVQH 470 Query: 1405 Y 1407 + Sbjct: 471 F 471
>P56594:CP2CL_CANFA Cytochrome P450 2C21 - Canis familiaris (Dog)| Length = 487 Score = 85.1 bits (209), Expect = 8e-16 Identities = 100/448 (22%), Positives = 184/448 (41%), Gaps = 28/448 (6%) Frame = +1 Query: 163 GRLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVV--SMDA 336 G+LPPG LP++G Q + S + + + YGPVF +P VV +A Sbjct: 24 GKLPPGPTPLPIIGNILQINTKNVSKSL----SKLAENYGPVFTVYFGMKPTVVLYGYEA 79 Query: 337 EVNRFIFQQEGKLFRSWYPDTANNIFGKESIASYDGSFHKYVRSFASRLF-----GLDSL 501 I + E R +P I G + S +G K R F+ + G ++ Sbjct: 80 VKEALIDRSEEFSGRGHFPLLDWTIQGLGIVFS-NGEKWKQTRRFSLTVLRNMGMGKKTV 138 Query: 502 RDVL----------LAEMDCNVTDSLAAWAAEPAIEVKDAVANMVFDLTAKKLIGFSPEK 651 D + L + + + D P + + F+ K + Sbjct: 139 EDRIQEEALYLVEALKKTNASPCDPTFLLGCAPCNVICSIIFQNRFEYDDKDFLTLLEYF 198 Query: 652 SRKLRKNFDAFFQGLVSFPL---YFPGTTFYRCIQGRKNVQKVLKDLLKER---LGAPEK 813 L + ++ Q +FPL Y PG+ + + N K + + +KE L Sbjct: 199 HENLLISSTSWIQLYNAFPLLIHYLPGS-HHVLFKNIANQFKFISEKIKEHEESLNFSNP 257 Query: 814 RHGDFLDEVVDELQSGRGVIDEKFAVDLMAALLFASFA----TVSSSLTIAMKFLSGHPN 981 R DF+D + +++ + +F +D + ++ F+ T S++L + L HP+ Sbjct: 258 R--DFIDYFLIKIEKEKHNKQSEFTMDNLIITIWDVFSAGTETTSTTLRYGLLVLLKHPD 315 Query: 982 VVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAPGIFRKTLT-D 1158 V ++EE ++ G ++ M +T V +EI R ++ P ++T D Sbjct: 316 VTAKVQEEIHRVV-----GRHRSPCMQDRSCMPYTDAVVHEIQRYIDLVPNNLPHSVTQD 370 Query: 1159 VQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGIR 1338 ++ + Y IP G ++ S +V + + F +P F+P + DE+ FM F G R Sbjct: 371 IKFREYLIPKGTTILTSLTSVLHDEKGFPNPDQFDPGHFLDENGSFKKSDYFMAFSAGKR 430 Query: 1339 LCVGAEFSRIQIALFLHTLVTKYRWKEI 1422 +CVG +R+++ L L ++ + K + Sbjct: 431 VCVGEGLARMELFLLLTNILQHFTLKPL 458
>P37122:C76A2_SOLME Cytochrome P450 76A2 - Solanum melongena (Eggplant) (Aubergine)| Length = 505 Score = 85.1 bits (209), Expect = 8e-16 Identities = 110/492 (22%), Positives = 202/492 (41%), Gaps = 40/492 (8%) Frame = +1 Query: 61 YSQVAFASLCGLAAVVAGWLAHCVYKWTNPACSTGRLPPGSMGLPLVGETFQFFKPSPSL 240 +S V F+++ L A + + N S+ + PPG GLP+ G F+ L Sbjct: 5 WSYVFFSAIIILPAFIL------FFSQKNTTKSSYKFPPGPPGLPIFGNMFE-------L 51 Query: 241 DVPAFYKQRLKR--YGPVFKTSLVGQPVVVSMDAEVNRFIFQQEGKLFRSWYPDTANNIF 414 + K + R YGPV L +V A+ + +F+ F + N Sbjct: 52 GTEPYKKMAVLRQKYGPVLWLKLGSTYTMVVQTAQASEELFKNHDISFANRVIPDVNQAH 111 Query: 415 ----GKESIASYDGSFHKYVRSFAS-RLFGLDSLRDVLLAEMDCNVTDSLAAWAAEPA-- 573 G +IA Y G F ++ R + +F + + C D++ W + A Sbjct: 112 SYYQGSLAIAPY-GPFWRFQRRICTIEMFVHKKISETEPVRRKC--VDNMLKWIEKEANS 168 Query: 574 ------IEVKDAVANMVFDLTAKKLIG--FSPEKSRKLRKNFDAF-----FQGLVSFPLY 714 IEV V F++ ++ + +S + + F A + G+ + Sbjct: 169 AEKGSGIEVTRFVFLASFNMLGNLILSKDLADLESEEASEFFIAMKRINEWSGIANVSDI 228 Query: 715 FPGTTFYRCIQGRKNVQK-------VLKDLLKERLGAPEKRHG-----DFLDEVVDELQS 858 FP + RK + + ++ LKER E++ G DFLD +++ + Sbjct: 229 FPFLKKFDLQSLRKKMARDMGKAVEIMSMFLKER--EEERKKGTEKGKDFLDVLLEFQGT 286 Query: 859 GR---GVIDEKFAVDLMAALLFASFATVSSSLTIAMKFLSGHPNVVESLKEEHEAILKKR 1029 G+ + E + + A T SSS+ A+ L HP + +K E ++ Sbjct: 287 GKDEPAKLSEHEIKIFVLEMFLAGTETTSSSVEWALTELLRHPEAMAKVKTEISQAIEPN 346 Query: 1030 EEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAPGIF-RKTLTDVQVKGYTIPAGWLVMI 1206 + S I +++ + V E R+ P + R+T+ D + GY +P V++ Sbjct: 347 RKFEDSDI-----ENLPYMQAVLKESLRLHPPLPFLIPRETIQDTKFMGYDVPKDTQVLV 401 Query: 1207 SPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNF--MPFGGGIRLCVGAEFSRIQIAL 1380 + A+ +PE ++DP++F P R+ SK +++ +PFG G R+CVG + Sbjct: 402 NAWAIGRDPECWDDPMSFKPERFLG-SKIDVKGQHYGLIPFGAGRRMCVGLPLGHRMMHF 460 Query: 1381 FLHTLVTKYRWK 1416 L +L+ ++ W+ Sbjct: 461 ALGSLLREFEWE 472
>Q9LXM3:C71BZ_ARATH Cytochrome P450 71B38 - Arabidopsis thaliana (Mouse-ear cress)| Length = 500 Score = 85.1 bits (209), Expect = 8e-16 Identities = 111/477 (23%), Positives = 195/477 (40%), Gaps = 36/477 (7%) Frame = +1 Query: 157 STGRLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDA 336 S G+LPPG +GLP++G Q K L +F+K + YGPV L PV+V Sbjct: 24 SKGKLPPGPIGLPIIGNLHQLGK----LLYKSFHKIS-QEYGPVVLLRLGVVPVIVVSSK 78 Query: 337 EVNRFIFQQEGKLFRSWYPDTANN-----IFGKESIASYDGSFHKYVRSFASRLFGLDSL 501 E + + L P TA F A + + + + LF + L Sbjct: 79 EGAEEVLKTHD-LETCTRPKTAATGLFTYNFKDIGFAPFGDDWREMRKITTLELFSVKKL 137 Query: 502 RDV-LLAEMDCNVTDSLAAWAAEPAIEVKDAVANMVFDLTAKKLIGFS------------ 642 + + E + + + + + + ++F TA + + Sbjct: 138 KSFRYIREEESELLVKKISKSVDETQNSSVDLRKVLFSFTASIICRLAFGQNFHQCDFVD 197 Query: 643 PEKSRKLRKNFDAFFQGLVSFPLYFPGTTFYRCIQGRKN------------VQKVLKDLL 786 EK +L +A G +F +FPG I G+ + + V+ D L Sbjct: 198 MEKVEELVLESEANL-GTFAFADFFPGGWLIDRISGQHSRVNKAFYKLTNFYKHVIDDHL 256 Query: 787 KERLGAPEKRHGDFLDEVVDELQSGRGVIDEKFAVD----LMAALLFASFATVSSSLTIA 954 K G P+ H D + ++D + K D +M+ + A ++++ Sbjct: 257 KT--GQPQD-HSDIVSVMLDMINKPTKADSFKVTYDHLKGVMSDIFLAGVNGGANTMIWT 313 Query: 955 MKFLSGHPNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAPG 1134 + LS HP V++ L+EE A+L +E IT E+ + + + V E R+ AP Sbjct: 314 LTELSRHPRVMKKLQEEIRAMLGPNKER----ITEEDLEKVEYLKLVMVETFRLHPPAPL 369 Query: 1135 IF-RKTLTDVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDES-KKSTMLK 1308 + R T++D++++GY IP ++ I+ A+ +P+ ++ P F P R+ D Sbjct: 370 LLPRLTMSDIKIQGYNIPKNTMIQINTYAIGRDPKYWKQPGEFIPERFLDSPIDYKGQHF 429 Query: 1309 NFMPFGGGIRLCVGAEFSRIQIALFLHTLVTKYRWKEIKGGEVQRISEIVFPEGYHI 1479 +PFG G R+C G + L L L+ + W G ++ I ++ EG+ I Sbjct: 430 ELLPFGAGRRICPGMATGITMVELGLLNLLYFFDWSLPNGMTIEDI-DMEEDEGFAI 485
>Q27664:CP6B2_HELAM Cytochrome P450 6B2 - Helicoverpa armigera (Cotton bollworm)| (Heliothis armigera) Length = 504 Score = 84.7 bits (208), Expect = 1e-15 Identities = 68/268 (25%), Positives = 132/268 (49%), Gaps = 20/268 (7%) Frame = +1 Query: 754 KNVQKVLKDLLKERLGAPEKRHGDFLDEVVDELQSGRGVIDEKFAVDL---------MAA 906 K + ++ ++ +R G P R+ DF+D +++ Q G + K+ ++ M A Sbjct: 240 KFFKNLVNTIVTQRNGKPSGRN-DFMDLILELRQMGE-ITSNKYGNNMSTLEITESVMCA 297 Query: 907 LLF----ASFATVSSSLTIAMKFLSGHPNVVESLKEEHEAILKKREEGAKSGITWEEYKS 1074 F A + T ++++ L+ +P++ L E + +K G K +T++ K Sbjct: 298 QAFVFYIAGYETSATTMAYLTYQLALNPDIQNKLIAEIDEAIKAN--GGK--VTYDTVKD 353 Query: 1075 MTFTAQVTNEISRVSNVAPGIFRKTLTDVQVKG--YTIPAGWLVMISPMAVHLNPELFED 1248 M + +V +E R+ ++ + RK + D ++ G I +V+ISP +H +P+ +++ Sbjct: 354 MKYLNKVFDETLRMYSIVEPLQRKAIRDYKLPGTDVVIEKDTVVLISPRGIHYDPKYYDN 413 Query: 1249 PLTFNPWRWQDESKKSTMLKNFMPFGGGIRLCVGAEFSRIQIALFLHTLVTKYRWKEIKG 1428 P FNP R+ E ++PFG G R C+G F R+Q L + L++K+R + K Sbjct: 414 PKQFNPERFFAEEVGKRHPCAYLPFGLGQRNCIGMRFGRLQSLLCITKLLSKFRLEPSKN 473 Query: 1429 G----EVQRISEIVFPE-GYHIQIIPRE 1497 +V+ I+ P+ G + I+PR+ Sbjct: 474 TDRNLQVEPYRFIIGPKGGIRLNIVPRK 501
>P20816:CP4A2_RAT Cytochrome P450 4A2 precursor - Rattus norvegicus (Rat)| Length = 504 Score = 84.7 bits (208), Expect = 1e-15 Identities = 57/201 (28%), Positives = 101/201 (50%), Gaps = 6/201 (2%) Frame = +1 Query: 802 APEKRHGDFLDEVV-DELQSGRGVIDEKFAVDLMAALLFASFATVSSSLTIAMKFLSGHP 978 A +KRH DFLD ++ +++ G+ + DE ++ +F T +S ++ L+ HP Sbjct: 277 ARKKRHLDFLDILLFAKMEDGKSLSDEDLRAEV-DTFMFEGHDTTASGISWVFYALATHP 335 Query: 979 NVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAPGIFRKTLTD 1158 E +EE ++IL G + +TW+ M +T E R+ + P + R+ + Sbjct: 336 EHQERCREEVQSIL-----GDGTSVTWDHLDQMPYTTMCIKEALRLYSPVPSVSRELSSP 390 Query: 1159 VQVK-GYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGI 1335 V G +IP G V I +H NP + +P F+P R+ +S + + ++PF GG Sbjct: 391 VTFPDGRSIPKGIRVTILIYGLHHNPSYWPNPKVFDPSRFSPDSPRHS--HAYLPFSGGA 448 Query: 1336 RLCVGAEFS----RIQIALFL 1386 R C+G +F+ ++ +AL L Sbjct: 449 RNCIGKQFAMNELKVAVALTL 469
>P20853:CP2A7_HUMAN Cytochrome P450 2A7 - Homo sapiens (Human)| Length = 494 Score = 84.7 bits (208), Expect = 1e-15 Identities = 106/482 (21%), Positives = 193/482 (40%), Gaps = 36/482 (7%) Frame = +1 Query: 157 STGRLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDA 336 S G+LPPG LP +G Q + F + YGPVF L + VVV Sbjct: 29 SRGKLPPGPTPLPFIGNYLQLNTEHICDSIMKFSEC----YGPVFTIHLGPRRVVVLCGH 84 Query: 337 EVNRFIFQQEGKLFRSWYPD-TANNIFGKESIASYDGSFHKYVRSFAS---RLFGLDS-- 498 + R + + F T + +F +A +G K + FA R FG+ Sbjct: 85 DAVREALVDQAEEFSGRGEQATFDWVFKGYGVAFSNGERAKQLLRFAIATLRDFGVGKRG 144 Query: 499 LRDVLLAEMDCNVTDSLAAWAA--EPAIEVKDAVANMV--------FDLTAKKLIG---- 636 + + + E + ++ A +P + V+N++ FD K+ + Sbjct: 145 IEERIQEESGFLIEAIRSSHGANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLSM 204 Query: 637 ------FSPEKSRKLRKNFDAFFQGLVSFPLYFPGTTFYRCIQGRKNVQKVLKDLLKERL 798 F+ + +L + F + + L P ++ +QG ++ + K + + Sbjct: 205 MLGIFQFTSTSTGQLYEMFSSVMKHLPG-----PQQQAFKLLQGLEDF--IAKKVEHNQR 257 Query: 799 GAPEKRHGDFLDEVVDELQSGRGVIDEKFAV-DLMAA---LLFASFATVSSSLTIAMKFL 966 DF+D + +Q + +F + +LM + L A TVS++L L Sbjct: 258 TLDPNSPQDFIDSFLIHMQEEEKNPNTEFYLKNLMMSTLNLFIAGTETVSTTLRYGFLLL 317 Query: 967 SGHPNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAP-GIFR 1143 HP V + EE + ++ K + +E+ M + V +EI R +V P + R Sbjct: 318 MKHPEVEAKVHEEIDRVIGKNRQPK-----FEDRTKMPYMEAVIHEIQRFGDVIPMSLAR 372 Query: 1144 KTLTDVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPF 1323 + D + + + +P G V +V +P F +P FNP + D+ + F+PF Sbjct: 373 RVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDDKGQFKKSDAFVPF 432 Query: 1324 GGGIRLCVGAEFSRIQIALFLHTLVTKYRWKEIKGGE-----VQRISEIVFPEGYHIQII 1488 G R C G +R+++ LF T++ +R K + + + + P Y + + Sbjct: 433 SIGKRYCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSSKHVGFATIPRNYTMSFL 492 Query: 1489 PR 1494 PR Sbjct: 493 PR 494
>O65782:C83B1_ARATH Cytochrome P450 83B1 - Arabidopsis thaliana (Mouse-ear cress)| Length = 499 Score = 84.7 bits (208), Expect = 1e-15 Identities = 104/484 (21%), Positives = 199/484 (41%), Gaps = 39/484 (8%) Frame = +1 Query: 94 LAAVVAGWLAHCVYKWTNPACSTG-RLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRL 270 L ++AG +A + + RLPPG GLP++G Q K +P F + Sbjct: 3 LLLIIAGLVAAAAFFFLRSTTKKSLRLPPGPKGLPIIGNLHQMEKFNPQ----HFLFRLS 58 Query: 271 KRYGPVFKTSLVGQPVVVSMDAEVNRFIFQQEGKLFRSWYPDTANNIFGKESIASYDG-- 444 K YGP+F + G+ + V AE+ + + + + F TA + + SY G Sbjct: 59 KLYGPIFTMKIGGRRLAVISSAELAKELLKTQDLNF------TARPLLKGQQTMSYQGRE 112 Query: 445 -------SFHKYVRSFAS-RLFG---LDSLRDVLLAEMDCNVTDSLAAWAAEPAIEVKDA 591 ++++ +R LF + S R V E + A +++ + Sbjct: 113 LGFGQYTAYYREMRKMCMVNLFSPNRVASFRPVREEECQRMMDKIYKAADQSGTVDLSEL 172 Query: 592 VANMVFDLTAKKLIGFS-PEKSRKLRKNFDAFFQ-----GLVSFPLYFPGTTFYRCIQGR 753 + + + ++ G E ++++ D ++ G + F FP F + G Sbjct: 173 LLSFTNCVVCRQAFGKRYNEYGTEMKRFIDILYETQALLGTLFFSDLFPYFGFLDNLTGL 232 Query: 754 --------KNVQKVLKDLLKERL--GAPEKRHGDFLDEVVDELQSGRGVIDEKFAVDLMA 903 K + L++LL E L P++ F+D ++ + I KF + + Sbjct: 233 SARLKKAFKELDTYLQELLDETLDPNRPKQETESFIDLLMQIYKDQPFSI--KFTHENVK 290 Query: 904 ALLFASFA----TVSSSLTIAMKFLSGHPNVVESLKEEHEAILKKREEGAKSGITWEEYK 1071 A++ T ++ + AM +L +P ++ ++E +++ G K ++ E+ Sbjct: 291 AMILDIVVPGTDTAAAVVVWAMTYLIKYPEAMKKAQDEVRSVI-----GDKGYVSEEDIP 345 Query: 1072 SMTFTAQVTNEISRVSNVAPGIF-RKTLTDVQVKGYTIPAGWLVMISPMAVHLNPELFED 1248 ++ + V E R+ V P + R+T+ D ++ GY IPA ++ ++ AV + + D Sbjct: 346 NLPYLKAVIKESLRLEPVIPILLHRETIADAKIGGYDIPAKTIIQVNAWAVSRDTAAWGD 405 Query: 1249 -PLTFNPWRWQDESKKSTMLK---NFMPFGGGIRLCVGAEFSRIQIALFLHTLVTKYRWK 1416 P F P R+ +E K +PFG G R+C + + L+ K+ W Sbjct: 406 NPNEFIPERFMNEHKGVDFKGQDFELLPFGSGRRMCPAMHLGIAMVEIPFANLLYKFDWS 465 Query: 1417 EIKG 1428 KG Sbjct: 466 LPKG 469
>P37117:C71A4_SOLME Cytochrome P450 71A4 - Solanum melongena (Eggplant) (Aubergine)| Length = 507 Score = 84.7 bits (208), Expect = 1e-15 Identities = 114/457 (24%), Positives = 200/457 (43%), Gaps = 37/457 (8%) Frame = +1 Query: 169 LPPGSMGLPLVGETFQFFK-PSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEVN 345 LPP LP++G Q P SL ++ ++YGPV L +PV+V+ + Sbjct: 36 LPPSPRKLPIIGNLHQLGSHPHRSL------RKLSQKYGPVMLLHLGSKPVIVASSVDAA 89 Query: 346 RFIFQQEGKLF--RSWYPDTANNIFGKESIA-SYDGSFHKYVRSFASRLF----GLDSLR 504 R I + ++ R Y + ++G + + S G + VRS + S R Sbjct: 90 RDILKTHDHVWATRPKYSIADSLLYGSKDVGFSPFGEYWWQVRSIVVLHLLSNKRVQSYR 149 Query: 505 DVLLAEMDCNVTDSLAAWAAEPAIEVKDAVANMVFDLTAKKLIGFSPEKSRK---LRKNF 675 DV E N+ + + I + + + + ++T++ +G + ++ + Sbjct: 150 DVR-EEETANMIEKIRQGCDASVINLGEHLCFLTNNITSRVALGRTYDERESGIDAKDIL 208 Query: 676 DAFFQGLVSFPL--YFPGTTFYRCIQGRKN-VQKVLKDL-------LKERLGAPEKRHGD 825 + F Q L +F + Y P + I G V+K+ K L ++E + +K Sbjct: 209 EQFLQLLDTFNVGDYIPWLKWVNKITGLDTKVEKIAKKLDTFLDSVIEEHIIRNKKEEYA 268 Query: 826 FLDEVVD------ELQSGRGVIDEKFAVDLMAALLFASFA----TVSSSLTIAMKFLSGH 975 DE D E+Q+G+ D D + A+L +FA T+ ++L M + Sbjct: 269 ITDEAKDFVDVLLEIQNGKET-DFPLQRDSLKAILLDAFAAGTDTIYTNLDWTMADVLRQ 327 Query: 976 PNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRV----SNVAPGIFR 1143 P +++L+ E + + KS IT ++ K+M + V E R+ S + P R Sbjct: 328 PRAMKTLQNEVRGLAQ-----GKSEITEDDLKNMQYLRAVIKESLRLHPPNSLLVP---R 379 Query: 1144 KTLTDVQVKGYT-IPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLK-NFM 1317 +++ DV++ GY IPA +I+ A+ +P +E+P F P R+ + LK + Sbjct: 380 ESMEDVKLLGYYHIPARTQALINVWAIGRDPLSWENPEEFCPERFLNNDIDMKGLKFELL 439 Query: 1318 PFGGGIRLCVGAEFSRIQIALFLHTLVTKYRWKEIKG 1428 PFG G R C G+ F+ I L L LV K+ + KG Sbjct: 440 PFGSGRRGCPGSSFAIAVIELALARLVHKFNFALPKG 476
>Q27902:CP6B4_PAPGL Cytochrome P450 6B4 - Papilio glaucus (Tiger swallowtail butterfly)| Length = 500 Score = 84.3 bits (207), Expect = 1e-15 Identities = 70/266 (26%), Positives = 130/266 (48%), Gaps = 26/266 (9%) Frame = +1 Query: 775 KDLLKERLGAPEKRHGDFLDEVVDELQSGRGVIDEKFAVD-----------LMAALLF-- 915 K ++++R G P R D +D ++ EL+ + + K D ++AA F Sbjct: 243 KTIIEQRGGKPTNRK-DLMDLIL-ELRQKKAIEPMKKTHDEQVTTLELTDSVIAAQTFIF 300 Query: 916 --ASFATVSSSLTIAMKFLSGHPNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTA 1089 A + T +S+++ + L+ +P++ E + E + LK+ IT++ MT+ Sbjct: 301 YAAGYETSASTMSFLLFELAENPDIQEKVIAEVDETLKRHN----GEITYDTLSEMTYLT 356 Query: 1090 QVTNEISRVSNVAPGIFRKTLTDVQVKG--YTIPAGWLVMISPMAVHLNPELFEDPLTFN 1263 QV +E R VA + R D V G T+ G V++S +H +P+ + DP F+ Sbjct: 357 QVFHETLRKYPVADILLRNAKADYAVPGTNVTLKKGQTVVVSGFGIHYDPKYYPDPEKFD 416 Query: 1264 PWRWQDESKKSTMLKNFMPFGGGIRLCVGAEFSRIQIALFLHTLVTKYRWKEIKGGEVQR 1443 P R+ E+ ++ ++PFG G R C+G F + Q+ + + L++K+R++ + Sbjct: 417 PERFSPENVRNRHPCAYIPFGAGQRKCLGMRFGQWQVQVCIIKLLSKFRFEP----STKT 472 Query: 1444 ISE--------IVFPE-GYHIQIIPR 1494 +SE +V+P+ G + IIPR Sbjct: 473 MSEFNYDPKRLLVYPKSGIFLNIIPR 498
>P24903:CP2F1_HUMAN Cytochrome P450 2F1 - Homo sapiens (Human)| Length = 491 Score = 84.3 bits (207), Expect = 1e-15 Identities = 102/441 (23%), Positives = 184/441 (41%), Gaps = 26/441 (5%) Frame = +1 Query: 163 GRLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEV 342 G+LPPG L ++G S D+ + K YG ++ L + VVV + Sbjct: 28 GKLPPGPRPLSILGNLLLLC----SQDMLTSLTKLSKEYGSMYTVHLGPRRVVVLSGYQA 83 Query: 343 NRFIFQQEGKLF--RSWYPDTANNIFGKESIASYDGSFHKYVRSFASRLF-----GLDSL 501 + +G+ F R YP N G IA G K +R F+ ++ G S+ Sbjct: 84 VKEALVDQGEEFSGRGDYPAFFNFTKGN-GIAFSSGDRWKVLRQFSIQILRNFGMGKRSI 142 Query: 502 RDVLLAEMDCNVTD--SLAAWAAEPAIEVKDAVANMVFDLTAKKLIGFSPEKSRKLRKNF 675 + +L E + D +P + +V+N++ + + E+ + + Sbjct: 143 EERILEEGSFLLADVRKTEGEPFDPTFVLSRSVSNIICSVLFGSRFDYDDERLLTIIRLI 202 Query: 676 DAFFQGLVSFP---LY------FPGTTFYRCIQGRKNVQ--KVLKDLLKERL-----GAP 807 + FQ ++S P LY FP + ++ Q K L+DL+ + +P Sbjct: 203 NDNFQ-IMSSPWGELYDILDPRFPSLLDWVPGPHQRIFQNFKCLRDLIAHSVHDHQASSP 261 Query: 808 EKRHGDFLDEVVDELQSGRGVIDEKFAVDLMAALLFASFATVSSSLTIAMKFLSGHPNVV 987 FL ++ +E + + LLF TVS++L A L +P V Sbjct: 262 RDFIQCFLTKMAEEKEDPLSHFHMDTLLMTTHNLLFGGTKTVSTTLHHAFLALMKYPKVQ 321 Query: 988 ESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAP-GIFRKTLTDVQ 1164 ++EE + ++ + A ++ +M +T V +E+ R +++ P + + D Sbjct: 322 ARVQEEIDLVVGRARLPAL-----KDRAAMPYTDAVIHEVQRFADIIPMNLPHRVTRDTA 376 Query: 1165 VKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGIRLC 1344 +G+ IP G V+ VH +P F P FNP + D ++ FMPF G RLC Sbjct: 377 FRGFLIPKGTDVITLLNTVHYDPSQFLTPQEFNPEHFLDANQSFKKSPAFMPFSAGRRLC 436 Query: 1345 VGAEFSRIQIALFLHTLVTKY 1407 +G +R+++ L+L ++ + Sbjct: 437 LGELLARMELFLYLTAILQSF 457
>Q92100:CP1A1_PLEPL Cytochrome P450 1A1 - Pleuronectes platessa (Plaice)| Length = 521 Score = 84.3 bits (207), Expect = 1e-15 Identities = 125/499 (25%), Positives = 204/499 (40%), Gaps = 46/499 (9%) Frame = +1 Query: 94 LAAVVAGWLAHCVYKWTNPACSTG-RLPPGSMGLPLVGETFQF-FKPSPSLDVPAFYKQR 267 L A+ L + + K+ G R PG LP++G KP SL + Sbjct: 18 LVAMTTMCLVYLILKFFQTEIPEGLRRLPGPKPLPIIGNVLGLGSKPYLSLTAMS----- 72 Query: 268 LKRYGPVFKTSLVGQPVVVSMDAEVNRFIFQQEGKLFRSWYPDTANNIF---GKESIASY 438 KRYG VF+ + +PVVV R ++G F PD + F GK S Sbjct: 73 -KRYGHVFQIQIGMRPVVVLSGTGTVRQALIKQGDEFAG-RPDLYSFRFINAGKSLAFST 130 Query: 439 DGS---------FHKYVRSFASRLFGLDSLRDVLLAEMDCNVTDSL---------AAWAA 564 D + + +RSF S L G +L E C + L A + Sbjct: 131 DQAGVWRARRKLAYSALRSF-STLEGTTPEYSCVLEEHICKEGEYLIKQLNTVMKADGSF 189 Query: 565 EPAIEVKDAVANMVF-----------DLTAKKLIGFSPEKSRKLRKNFDAFFQGLVSFPL 711 +P + +VAN++ D L+ S E R + A F ++ Sbjct: 190 DPFRHIVVSVANVICGMCFGRRYDHDDQELVSLVTLSDEFGRVVGSGNPADFIPILQ--- 246 Query: 712 YFPGTTFYRCIQGRKNVQKVLKDLLKERLGAPEKRH-GDFLDEVVDELQ-------SGRG 867 Y P ++ ++ + ++ ++ E K + D D ++D + S Sbjct: 247 YLPSAEMKNFLRINEHFTEFVQKIVTEHYTTFNKDNIRDITDSLIDHCEDRKLDENSNVQ 306 Query: 868 VIDEKFAVDLMAALLFASFATVSSSLTIAMKFLSGHPNVVESLKEEHEAILKKREEGAKS 1047 + DEK V ++ L A F TVS++L+ ++ +L HP + E L +E E + G Sbjct: 307 MSDEKI-VGIVNDLFGAGFDTVSTALSWSVMYLVAHPEIQERLYQEIED-----KVGLDR 360 Query: 1048 GITWEEYKSMTFTAQVTNEISRVSNVAP-GIFRKTLTDVQVKGYTIPAGWLVMISPMAVH 1224 + ++ F EI R S+ P I T D + GY IP V I+ ++ Sbjct: 361 MPLLSDKPNLPFLEAFILEILRHSSFLPFTIPHCTTKDTSLNGYFIPKDTCVFINQWQIN 420 Query: 1225 LNPELFEDPLTFNPWRW--QDESKKSTM-LKNFMPFGGGIRLCVGAEFSRIQIALFLHTL 1395 +PEL++DP +FNP R+ D S+ + + + M FG G R C+G +R ++ LFL + Sbjct: 421 HDPELWKDPSSFNPDRFLSADGSEVNKLDGEKVMAFGMGKRRCIGEVIARNEVYLFLAII 480 Query: 1396 VTKYRWKEIKGGEVQRISE 1452 + K + I G ++ E Sbjct: 481 IQKLHFLPIPGEKLDMTPE 499
>Q92113:CP17A_SQUAC Cytochrome P450 17A1 - Squalus acanthias (Spiny dogfish)| Length = 509 Score = 84.3 bits (207), Expect = 1e-15 Identities = 111/469 (23%), Positives = 198/469 (42%), Gaps = 46/469 (9%) Frame = +1 Query: 139 WTNPACSTGRLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRL-KRYGPVFKTSLVGQP 315 +T S GRLP PL+G P P Q+L K YG +F + Sbjct: 22 FTQRKLSGGRLPKCLPSFPLIGSLLSLRSDLP----PHLLFQKLQKTYGNLFSLMMGPHY 77 Query: 316 VVVSMDAEVNRFIFQQEGKLFRSWYPDTANNIF---GKESIASYDG---SFHKYVRSFAS 477 VV + + + + ++GK+F ++ GK+ G FH+ + A Sbjct: 78 AVVINNHQHAKEVLLKKGKIFAGRPSMVTTDLLSRGGKDIAFGKYGPAWKFHRKLVLSAL 137 Query: 478 RLFGLDS--LRDVLLAEMD--CNVTDSLAAWAAEPAIEVKDAVANMVFDLTAKKLIGFSP 645 LFG S + ++ E C+ + L A + +V AV N++ L Sbjct: 138 HLFGDGSAGIEKMICQEATSMCSTFERLNNAAHDMMPDVTRAVTNVICLLCFNSTYEKED 197 Query: 646 EKSRKLRKNFDAFFQGLVS----------FPL--YFPGT---TFYRCIQGRKNV-QKVLK 777 + + +RK + QG+V+ FP +FP T +CI R ++ QK + Sbjct: 198 PEFQTMRK----YSQGIVNTVAKDSLIDIFPWLQFFPNENLHTLKQCIATRDSILQKKFE 253 Query: 778 D----------------LLKERLGAPEKRHGDFLDEVVDELQSGRGVIDEKFAVDLMAAL 909 D LLK ++ A V E G+ D+ + + A + Sbjct: 254 DHKANYSSDSANDLFNILLKAKMNAENNNSS------VHEA----GLTDDHMVMTV-ADI 302 Query: 910 LFASFATVSSSLTIAMKFLSGHPNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTA 1089 A T S++ + +L HP V + ++EE ++ + G + + +M F Sbjct: 303 FGAGVETSSTAFAWMIIYLIHHPEVQKKIQEEIDSNI-----GFERTPKMSDKGNMNFLN 357 Query: 1090 QVTNEISRVSNVAPGIF-RKTLTDVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNP 1266 +EI R+ V+P + L D + YTIP G V+I+ A+H + + +++P F+P Sbjct: 358 ATIHEILRIQPVSPLLIPHVALADSSIGDYTIPKGTRVIINLWAIHHDEKEWKNPDAFDP 417 Query: 1267 WRWQDESKK--STMLKNFMPFGGGIRLCVGAEFSRIQIALFLHTLVTKY 1407 R+ DE K + ++++PFG G R+C+G +R+++ LF ++ ++ Sbjct: 418 GRFLDEDGKYVCSSSESYLPFGAGTRVCLGEMLARMELFLFTSWILQRF 466
>Q9V9L1:CP6W1_DROME Probable cytochrome P450 6w1 - Drosophila melanogaster (Fruit fly)| Length = 514 Score = 84.0 bits (206), Expect = 2e-15 Identities = 95/448 (21%), Positives = 189/448 (42%), Gaps = 41/448 (9%) Frame = +1 Query: 193 PLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTS------LVGQPVVVSMDAEVNRFI 354 P+VG T +F + VP F + + P F+ + +P +V D E+ + + Sbjct: 37 PVVGCTREFL----TAKVPFFEQIQKFHEAPGFENEPFVGVYMTHRPALVIRDLELIKTV 92 Query: 355 FQQEGKLF--RSWYPDTANNIFGKESIASYDGSFHKYVRSFASRLFGLDSLRDV--LLAE 522 ++ + F R D N+ G +++ + +R+ S +F ++ + L+ + Sbjct: 93 MIKKFQYFNNRVLQTDPHNDALGYKNLFFARSPGWRELRTKISPVFTSGKIKQMYPLMVK 152 Query: 523 MDCNVTDSLAAWAAEPAIEVKDAVANMVFDLTAKKLIGFSPEKSRKLRKNFDAFFQGLVS 702 + N+ DS + ++VKD + DL A G + + F F+ Sbjct: 153 IGKNLQDSAERLGSGTEVQVKDLCSRFTTDLIATIAFGVEANALQDAKSEF--FYHNRAI 210 Query: 703 FPLYFPGTTFYRCI-----------------QGRKNVQKVLKDLLKERLGAPEKRHG--D 825 F L + I + K ++ + +LKER EKR+ D Sbjct: 211 FSLTLSRGIDFAIIFMIPALASLARVKLFSRETTKFIRSSVNYVLKERERTGEKRNDLID 270 Query: 826 FLDEVVDELQSGRGVIDEKFAVDLMAA----LLFASFATVSSSLTIAMKFLSGHPNVVES 993 L + E + G + ++ +D + A A F T +S++T+ + L+ + + + Sbjct: 271 ILLALKREAAANPGKMSKEVDLDYLVAQAAVFQTAGFETSASTMTMTLYELAKNEALQDR 330 Query: 994 LKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAPGIFRKTLTDVQVKG 1173 L++E G + I++E + M + +QV NE R + I R+ + + Sbjct: 331 LRQEIVDFF-----GDEDHISYERIQEMPYLSQVVNETLRKYPIVGYIERECSQPAEGER 385 Query: 1174 YTI--------PAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGG 1329 +T+ P G + +S +AVH +P+ + DP ++P R+ ++ + + +MPFG Sbjct: 386 FTLEPFHNMELPHGMSIYMSTVAVHRDPQYWPDPEKYDPERFNSSNRDNLNMDAYMPFGV 445 Query: 1330 GIRLCVGAEFSRIQIALFLHTLVTKYRW 1413 G R C+G +Q L L ++ +R+ Sbjct: 446 GPRNCIGMRLGLLQSKLGLVHILRNHRF 473
>Q95031:CP6B6_HELAM Cytochrome P450 6B6 - Helicoverpa armigera (Cotton bollworm)| (Heliothis armigera) Length = 504 Score = 84.0 bits (206), Expect = 2e-15 Identities = 67/269 (24%), Positives = 131/269 (48%), Gaps = 21/269 (7%) Frame = +1 Query: 754 KNVQKVLKD-LLKERLGAPEKRHGDFLDEVVDELQSGRGVIDEKFAV---------DLMA 903 KN K L D ++ +R G P R+ DF+D +++ Q G V K+ +++ Sbjct: 239 KNFFKSLVDNIVAQRNGKPSGRN-DFMDLILELRQLGE-VTSNKYGSSASSLEITDEVIC 296 Query: 904 ALLF----ASFATVSSSLTIAMKFLSGHPNVVESLKEEHEAILKKREEGAKSGITWEEYK 1071 A F A + T ++++ + L+ P++ L E + +LK + +T++ K Sbjct: 297 AQAFVFYIAGYETSATTMAYMIYQLALSPDIQNKLIAEVDEVLKAND----GKVTYDTVK 352 Query: 1072 SMTFTAQVTNEISRVSNVAPGIFRKTLTDVQVKG--YTIPAGWLVMISPMAVHLNPELFE 1245 M + + +E R+ ++ + RK D ++ G I +V+ISP +H +P+ ++ Sbjct: 353 EMKYMNKAFDETLRMYSIVEPLQRKATRDYKIPGTDVVIEKDTIVLISPRGIHYDPKYYD 412 Query: 1246 DPLTFNPWRWQDESKKSTMLKNFMPFGGGIRLCVGAEFSRIQIALFLHTLVTKYRWKEIK 1425 +P FNP R+ E ++PFG G R C+G F R+Q L + +++K+R + K Sbjct: 413 NPKQFNPDRFDAEEVGKRHPCAYLPFGLGQRNCIGMRFGRLQSLLCITKILSKFRIEPSK 472 Query: 1426 GG----EVQRISEIVFPE-GYHIQIIPRE 1497 +V+ ++ P+ G + ++PR+ Sbjct: 473 NTDRNLQVEPHRGLIGPKGGIRVNVVPRK 501
>P11372:CP2CF_RABIT Cytochrome P450 2C15 - Oryctolagus cuniculus (Rabbit)| Length = 378 Score = 84.0 bits (206), Expect = 2e-15 Identities = 79/329 (24%), Positives = 146/329 (44%), Gaps = 17/329 (5%) Frame = +1 Query: 487 GLDSLRDVLLAEMDCNVTD--SLAAWAAEPAIEVKDAVANMVFDLTAKKLIGFSPEKSRK 660 G S+ D + E C V + A +P + A N++ + + E K Sbjct: 28 GKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICSIIFHNRFDYKDEHFLK 87 Query: 661 LRKNFDAFFQGLVS--------FPL---YFPG--TTFYRCIQGRKNVQKVLKDLLKERLG 801 L + F+ + L S FP+ Y PG T + I+ KN +++ + + + Sbjct: 88 LMEKFNENVRILSSPWLQICNNFPVLTDYLPGIHNTLVKNIEYTKNF--IMEKVKEHQKS 145 Query: 802 APEKRHGDFLDEVVDEL-QSGRGVIDEKFAVDLMAALLFASFATVSSSLTIAMKFLSGHP 978 DF+D + ++ Q + V ++ L A T S++L+I++ L HP Sbjct: 146 LDVNNPRDFIDCFLIKMDQENHLEFTLESLVTTVSDLFGAGTETTSTTLSISLLLLLKHP 205 Query: 979 NVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAPGIFRKTLT- 1155 V ++EE E ++ G ++ M +T V +EI R ++ P +T Sbjct: 206 EVAAKVQEEIERVI-----GRHRSPCMQDRSRMPYTDAVIHEIQRYIDLIPINLPHAVTR 260 Query: 1156 DVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGI 1335 D++ + Y IP G ++ S +V + + F +P F+P + DES FMPF G Sbjct: 261 DIKFRNYFIPKGMNIITSLTSVLHDEKEFPNPKVFDPGHFLDESGNFKKSDYFMPFSAGK 320 Query: 1336 RLCVGAEFSRIQIALFLHTLVTKYRWKEI 1422 R+CVG +R+++ LFL +++ ++ + + Sbjct: 321 RMCVGEGLARMELFLFLTSILQNFKLQSL 349
>P79402:CP242_PIG Cytochrome P450 2C42 - Sus scrofa (Pig)| Length = 327 Score = 84.0 bits (206), Expect = 2e-15 Identities = 55/223 (24%), Positives = 107/223 (47%), Gaps = 5/223 (2%) Frame = +1 Query: 769 VLKDLLKERLGAPEKRHGDFLDEVVDELQSGRGVIDEKFAVDLMAALLFASFA----TVS 936 VLK + + + DF+D + +++ + ++ ++ + A + F+ T S Sbjct: 81 VLKKVKEHQESLDINNPRDFIDCFLIKMEQEKHNQQSEYTIENLIATVSDMFSAGTETTS 140 Query: 937 SSLTIAMKFLSGHPNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRV 1116 +++ + L HP V ++EE + ++ G ++ M +T V +EI R Sbjct: 141 TTMRYGLLLLLKHPEVTAKVQEEIDRVI-----GRHRSACMQDRSHMPYTDAVVHEIQRY 195 Query: 1117 SNVAPGIFRKTLT-DVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKK 1293 ++ P +T D++ + Y IP G ++ S +V + + F +P F+P + DES Sbjct: 196 IDLVPTNLPHAVTCDIKFRNYLIPKGTTILTSLTSVLYDCKAFPNPEVFDPGHFLDESGN 255 Query: 1294 STMLKNFMPFGGGIRLCVGAEFSRIQIALFLHTLVTKYRWKEI 1422 FMPF G R+CVG +R+++ LFL T++ K+ K + Sbjct: 256 FKKSDYFMPFSTGKRICVGEGLARMELFLFLTTILQKFNLKSV 298
>O42457:CP1A1_SPAAU Cytochrome P450 1A1 - Sparus aurata (Gilthead sea bream)| Length = 521 Score = 84.0 bits (206), Expect = 2e-15 Identities = 117/488 (23%), Positives = 199/488 (40%), Gaps = 41/488 (8%) Frame = +1 Query: 94 LAAVVAGWLAHCVYKWTNPACSTGRLP-PGSMGLPLVGETFQFFKPSPSLDVPAFYKQRL 270 L A++ L + + K+ G PG LP++G + + +P L + A K Sbjct: 18 LVAIITMCLVYMILKFFRTEIPEGLCQLPGPKPLPIIGNVLEVGR-NPYLSLTAMSK--- 73 Query: 271 KRYGPVFKTSLVGQPVVVSMDAEVNRFIFQQEGKLFRSWYPDTANNIF---GKESIASYD 441 RYG VF+ + +PVVV +E R ++G F PD + F GK S D Sbjct: 74 -RYGDVFQIQIGMRPVVVLSGSETVRQALIKQGDDFAG-RPDLYSFRFINDGKSLAFSTD 131 Query: 442 -GSFHKYVRSFASRLFGLDSLRDVLLAEMDCNVTDSLAAWAA----------------EP 570 + R A S + E C + + ++ A +P Sbjct: 132 QAGVWRARRKLAYSALRSFSTLEGTTPEYSCALEEHVSKEAEYLVKQLNTVMETDGSFDP 191 Query: 571 AIEVKDAVANMVFDLTAKKLIGFSPEKSRKLRKNFDAFFQGLVS------FPL--YFPGT 726 + +VAN++ + + + ++ L D F Q + S P+ Y P T Sbjct: 192 FRHIVVSVANVICGMCFGRRYDHNNQELLNLVNLSDEFGQVVASGNPADFIPILQYLPST 251 Query: 727 TFYRCIQGRKNVQKVLKDLLKERLGAPEKRH-GDFLDEVVDELQ-------SGRGVIDEK 882 + + + ++ ++ E +K + D D ++D + S + DEK Sbjct: 252 SMKKFVSINDRFNAFVQKIVSEHYTTFDKDNIRDITDSLIDHCEDRKLDENSNVQMSDEK 311 Query: 883 FAVDLMAALLFASFATVSSSLTIAMKFLSGHPNVVESLKEEHEAILKKREEGAKSGITWE 1062 V ++ L A F T+S++L+ ++ +L +P + E L +E K G Sbjct: 312 -VVGIVNDLFGAGFDTISTALSWSVMYLVAYPEIQERLYQE-----MKESVGLDRTPCLS 365 Query: 1063 EYKSMTFTAQVTNEISRVSNVAP-GIFRKTLTDVQVKGYTIPAGWLVMISPMAVHLNPEL 1239 + + F EI R S+ P I + D + GY IP V I+ ++ +PEL Sbjct: 366 DKPKLPFLEAFILEIFRHSSFLPFTIPHCSSKDTSLNGYFIPKDTCVFINQWQINHDPEL 425 Query: 1240 FEDPLTFNPWRW-QDESKKSTML--KNFMPFGGGIRLCVGAEFSRIQIALFLHTLVTKYR 1410 ++DP +FNP R+ + + L + M FG G R C+G +R ++ LFL LV R Sbjct: 426 WKDPSSFNPDRFLNTDGTELNKLEGEKMMVFGLGKRRCIGEVIARNEVFLFLAILVQNLR 485 Query: 1411 WKEIKGGE 1434 + K GE Sbjct: 486 F-HAKPGE 492
>P63719:CP139_MYCTU Putative cytochrome P450 139 - Mycobacterium tuberculosis| Length = 430 Score = 84.0 bits (206), Expect = 2e-15 Identities = 91/406 (22%), Positives = 164/406 (40%), Gaps = 21/406 (5%) Frame = +1 Query: 250 AFYKQRLKRYGPVFKTSLVGQPVVVSMDAEVNRFIFQQEGKLFRSWYPDTANNIFGKESI 429 A Y+ R GP+ + G + AE NRF+F S ++ + G ++ Sbjct: 11 ALYRWR----GPLINAGVGGHGYTYLLGAEANRFVFANADAFSWSQTFESLVPVDGPTAL 66 Query: 430 ASYDGSFHKYVRSFASRLFGLDSLRDVLLAEMDCNVTDSLAAWAAEPAIEVKDAVANMVF 609 DG+ H+ RS + ++ + A M N+ + W +++ + + V Sbjct: 67 IVSDGADHRRRRSVVAPGLRHHHVQRYV-ATMVSNIDTVIDGWQPGQRLDIYQELRSAVR 125 Query: 610 DLTAKKLIGFSPEKSRKLRKNFDAFFQGLVSFPLY-----------------FPGTTFYR 738 TA+ L G ++L + D F G PL PG + R Sbjct: 126 RSTAESLFG------QRLAVHSD--FLGEQLQPLLDLTRRPPQVMRLQQRVNSPG--WRR 175 Query: 739 CIQGRKNVQKVLKDLLKERLGAPEKRHGDFLDEVVDELQSGRGVIDEKFAVDLMAALLFA 918 + RK + ++ + + AP + L ++ + + D + +L+ A Sbjct: 176 AMAARKRIDDLIDAQIADARTAP-RPDDHMLTTLISGCSEEGTTLSDNEIRDSIVSLITA 234 Query: 919 SFATVSSSLTIAMKFLSGHPNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVT 1098 + T S +L A+ L P ES E +L R A ++ ++T+ V Sbjct: 235 GYETTSGALAWAIYALLTVPGTWESAASEVARVLGGRVPAA------DDLSALTYLNGVV 288 Query: 1099 NEISRVSNVAPGIF--RKTLTDVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWR 1272 +E R+ +PG+ R+ L D+ G+ I AG L++ S H PE++ +P F P R Sbjct: 289 HETLRL--YSPGVISARRVLRDLWFDGHRIRAGRLLIFSAYVTHRLPEIWPEPTEFRPLR 346 Query: 1273 WQDESK--KSTMLKNFMPFGGGIRLCVGAEFSRIQIALFLHTLVTK 1404 W + + F+PF GG+ C+GA + ++ + L LV + Sbjct: 347 WDPNAADYRKPAPHEFIPFSGGLHRCIGAVMATTEMTVILARLVAR 392
>P63720:CP139_MYCBO Putative cytochrome P450 139 - Mycobacterium bovis| Length = 430 Score = 84.0 bits (206), Expect = 2e-15 Identities = 91/406 (22%), Positives = 164/406 (40%), Gaps = 21/406 (5%) Frame = +1 Query: 250 AFYKQRLKRYGPVFKTSLVGQPVVVSMDAEVNRFIFQQEGKLFRSWYPDTANNIFGKESI 429 A Y+ R GP+ + G + AE NRF+F S ++ + G ++ Sbjct: 11 ALYRWR----GPLINAGVGGHGYTYLLGAEANRFVFANADAFSWSQTFESLVPVDGPTAL 66 Query: 430 ASYDGSFHKYVRSFASRLFGLDSLRDVLLAEMDCNVTDSLAAWAAEPAIEVKDAVANMVF 609 DG+ H+ RS + ++ + A M N+ + W +++ + + V Sbjct: 67 IVSDGADHRRRRSVVAPGLRHHHVQRYV-ATMVSNIDTVIDGWQPGQRLDIYQELRSAVR 125 Query: 610 DLTAKKLIGFSPEKSRKLRKNFDAFFQGLVSFPLY-----------------FPGTTFYR 738 TA+ L G ++L + D F G PL PG + R Sbjct: 126 RSTAESLFG------QRLAVHSD--FLGEQLQPLLDLTRRPPQVMRLQQRVNSPG--WRR 175 Query: 739 CIQGRKNVQKVLKDLLKERLGAPEKRHGDFLDEVVDELQSGRGVIDEKFAVDLMAALLFA 918 + RK + ++ + + AP + L ++ + + D + +L+ A Sbjct: 176 AMAARKRIDDLIDAQIADARTAP-RPDDHMLTTLISGCSEEGTTLSDNEIRDSIVSLITA 234 Query: 919 SFATVSSSLTIAMKFLSGHPNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVT 1098 + T S +L A+ L P ES E +L R A ++ ++T+ V Sbjct: 235 GYETTSGALAWAIYALLTVPGTWESAASEVARVLGGRVPAA------DDLSALTYLNGVV 288 Query: 1099 NEISRVSNVAPGIF--RKTLTDVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWR 1272 +E R+ +PG+ R+ L D+ G+ I AG L++ S H PE++ +P F P R Sbjct: 289 HETLRL--YSPGVISARRVLRDLWFDGHRIRAGRLLIFSAYVTHRLPEIWPEPTEFRPLR 346 Query: 1273 WQDESK--KSTMLKNFMPFGGGIRLCVGAEFSRIQIALFLHTLVTK 1404 W + + F+PF GG+ C+GA + ++ + L LV + Sbjct: 347 WDPNAADYRKPAPHEFIPFSGGLHRCIGAVMATTEMTVILARLVAR 392
>Q9HCS2:CP4FC_HUMAN Cytochrome P450 4F12 - Homo sapiens (Human)| Length = 524 Score = 83.6 bits (205), Expect = 2e-15 Identities = 53/199 (26%), Positives = 96/199 (48%), Gaps = 2/199 (1%) Frame = +1 Query: 823 DFLDEVV-DELQSGRGVIDEKFAVDLMAALLFASFATVSSSLTIAMKFLSGHPNVVESLK 999 DF+D ++ + + G+ + DE + +F T +S L+ + L+ HP E + Sbjct: 297 DFIDVLLLSKDEDGKALSDEDIRAEA-DTFMFGGHDTTASGLSWVLYNLARHPEYQERCR 355 Query: 1000 EEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAPGIFRKTLTDVQVK-GY 1176 +E + +LK R+ I W++ + F E R+ AP I R D+ + G Sbjct: 356 QEVQELLKDRDP---KEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGR 412 Query: 1177 TIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGIRLCVGAE 1356 IP G +I + VH NP ++ DP ++P+R+ E+ K F+PF G R C+G Sbjct: 413 VIPKGITCLIDIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQA 472 Query: 1357 FSRIQIALFLHTLVTKYRW 1413 F+ ++ + L ++ +R+ Sbjct: 473 FAMAEMKVVLALMLLHFRF 491
>P08516:CP4AA_RAT Cytochrome P450 4A10 - Rattus norvegicus (Rat)| Length = 509 Score = 83.6 bits (205), Expect = 2e-15 Identities = 59/221 (26%), Positives = 111/221 (50%), Gaps = 5/221 (2%) Frame = +1 Query: 760 VQKVLKDLLK---ERLGAPEKRHGDFLDEVV-DELQSGRGVIDEKFAVDLMAALLFASFA 927 V K+ KD L+ E +KR DFLD ++ +++G + D+ ++ +F Sbjct: 265 VIKLRKDQLQNAGELEKVKKKRRLDFLDILLLARMENGDSLSDKDLRAEV-DTFMFEGHD 323 Query: 928 TVSSSLTIAMKFLSGHPNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEI 1107 T +S ++ L+ HP + +EE +++L G S ITW+ + +T E Sbjct: 324 TTASGVSWIFYALATHPEHQQRCREEVQSVL-----GDGSSITWDHLDQIPYTTMCIKEA 378 Query: 1108 SRVSNVAPGIFRKTLTDVQVK-GYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDE 1284 R+ PGI R+ T V G ++P G V +S +H NP+++ +P F+P R+ + Sbjct: 379 LRLYPPVPGIVRELSTSVTFPDGRSLPKGIQVTLSIYGLHHNPKVWPNPEVFDPSRFAPD 438 Query: 1285 SKKSTMLKNFMPFGGGIRLCVGAEFSRIQIALFLHTLVTKY 1407 S + + +F+PF GG R C+G +F+ ++ + + + ++ Sbjct: 439 SPRHS--HSFLPFSGGARNCIGKQFAMSEMKVIVALTLLRF 477
>O88833:CP4AA_MOUSE Cytochrome P450 4A10 - Mus musculus (Mouse)| Length = 509 Score = 83.6 bits (205), Expect = 2e-15 Identities = 59/221 (26%), Positives = 112/221 (50%), Gaps = 5/221 (2%) Frame = +1 Query: 760 VQKVLKDLLK---ERLGAPEKRHGDFLDEVV-DELQSGRGVIDEKFAVDLMAALLFASFA 927 V K+ KD L+ E +KR DFLD ++ +++G + D+ ++ +F Sbjct: 265 VIKLRKDQLQDEGELEKIKKKRRLDFLDILLFARMENGDSMSDKDLRAEV-DTFMFEGHD 323 Query: 928 TVSSSLTIAMKFLSGHPNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEI 1107 T +S ++ L+ HP+ + +EE +++L G S ITW+ + +T E Sbjct: 324 TTASGVSWIFYALATHPDHQQRCREEVQSLL-----GDGSSITWDHLDQIPYTTMCIKEA 378 Query: 1108 SRVSNVAPGIFRKTLTDVQVK-GYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDE 1284 R+ PGI R+ T V G ++P G V +S +H NP+++ +P F+P R+ + Sbjct: 379 LRLYPPVPGIVRELSTSVTFPDGRSLPKGVQVTLSIYGLHHNPKVWPNPEVFDPSRFAPD 438 Query: 1285 SKKSTMLKNFMPFGGGIRLCVGAEFSRIQIALFLHTLVTKY 1407 S + + +F+PF GG R C+G +F+ ++ + + + ++ Sbjct: 439 SPRHS--HSFLPFSGGARNCIGKQFAMSELKVIVALTLLRF 477
>O93297:CP2K4_ONCMY Cytochrome P450 2K4 - Oncorhynchus mykiss (Rainbow trout) (Salmo| gairdneri) Length = 504 Score = 83.6 bits (205), Expect = 2e-15 Identities = 101/447 (22%), Positives = 184/447 (41%), Gaps = 25/447 (5%) Frame = +1 Query: 163 GRLPPGSMGLPLVGETFQFFKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEV 342 G+ PPG LPL+G Q P + + K+YG +F + VVV + Sbjct: 39 GKEPPGPRPLPLLGNMLQLDLKKPYCTLC----ELSKKYGSIFTVHFGSKKVVVLAGYKT 94 Query: 343 NRFIFQQEGKLFRSWYPDTANNIFGK-ESIASYDGSFHKYVRSFAS---RLFGLDSL--R 504 + + + F A F + I +G K +R FA R FG+ Sbjct: 95 VKQALVNQAEDFGERDITPAFYDFNQGHGILFTNGDSWKEMRRFALTNLRDFGMGKKGSE 154 Query: 505 DVLLAEMD--CNVTDSLAAWAAEPAIEVKDAVANMVFDLTAKKLIGFSPEKSRKL--RKN 672 + +L E+ V + A + V AV+N++ + ++ + R N Sbjct: 155 EKILEEIPYLIEVLEKHEGKAFDTTQSVHHAVSNIISAIVYGSRFEYTDPLFTGMVDRVN 214 Query: 673 FDAFFQGLVSFPLY--FP--GTTFYRCIQGRKNVQKVLKDLLKERLGAPEKRHGDFLDEV 840 + G S +Y FP G + +KNV + ++++ G E + Sbjct: 215 ENVHLIGSASIQMYNMFPWLGPWINNLTRLKKNVADLKMEVIELVRGLKETLNPHMCRGF 274 Query: 841 VDELQSGRGVIDEKFAVDL----------MAALLFASFATVSSSLTIAMKFLSGHPNVVE 990 VD + ++E +D + L A T ++L + ++ +P++ + Sbjct: 275 VDSFLVRKQTLEESGKMDSFYHDDNLLFSIGNLFGAGTDTTGTTLRWGLLLMAKYPHIQD 334 Query: 991 SLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAP-GIFRKTLTDVQV 1167 ++EE ++ R+ E+ K++ +T V +E R++N++P + T DV Sbjct: 335 QVQEEISRVIGSRQTLV------EDRKNLPYTDAVIHETQRLANISPMAVPHTTSRDVTF 388 Query: 1168 KGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTMLKNFMPFGGGIRLCV 1347 +GY I G V+ M+V + +E P TFNP + DE FM F G R+C+ Sbjct: 389 QGYFIKKGTSVIPLLMSVLQDDNEWESPNTFNPSHFLDEQGGFVKRDAFMAFSAGRRVCL 448 Query: 1348 GAEFSRIQIALFLHTLVTKYRWKEIKG 1428 G +R+++ LF +L+ ++R+ G Sbjct: 449 GEGLARMELFLFFTSLLQRFRFSPPPG 475
>O69653:CP137_MYCTU Putative cytochrome P450 137 - Mycobacterium tuberculosis| Length = 476 Score = 83.6 bits (205), Expect = 2e-15 Identities = 102/426 (23%), Positives = 174/426 (40%), Gaps = 15/426 (3%) Frame = +1 Query: 268 LKRYGPVFKTSLV--GQPVVVSMDAEVNRFIFQQEGKLFRSWYPDTANNIFGKESIASYD 441 ++RYGP+ ++ G +VS A L A I+G S+ + Sbjct: 74 IRRYGPIMTMPILSLGDVAIVSDSALAKEVFTAPTDVLLGGEGVGPAAAIYGSGSMFVQE 133 Query: 442 GSFHKYVRSFASR-LFGLDSLRDVLLAEMDCNVTDSLAAWAAEPAIEVKDAVANMVFDLT 618 H R + L G R V + E ++ W + + +++ D+ Sbjct: 134 EPEHLRRRKLLTPPLHGAALDRYVPIIENSTRA--AMHTWPVDRPFAMLTVARSLMLDVI 191 Query: 619 AKKLIGFS-PEKSRKLRKNFDAFF------QGLVSFPLYFPGTTFYRCIQGRKN--VQKV 771 K + G PE+ R+L + F+ Q V + L G + R N + V Sbjct: 192 VKVIFGVDDPEEVRRLGRPFERLLNLGVSEQLTVRYALRRLGALRVWPARARANTEIDDV 251 Query: 772 LKDLLKERLGAPE--KRHGDFLDEVVDEL-QSGRGVIDEKFAVDLMAALLFASFATVSSS 942 + L+ +R P +RH D L +V +SG + D + DL+ L+ A T +++ Sbjct: 252 VMALIAQRRADPRLGERH-DVLSLLVSARGESGEQLSDSEIRDDLIT-LVLAGHETTATT 309 Query: 943 LTIAMKFLSGHPNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSN 1122 L A L HP +A+ + R E G FT V NE RV Sbjct: 310 LAWAFDLLLHHP----------DALRRVRAEAVGGG--------EAFTTAVINETLRVRP 351 Query: 1123 VAPGIFRKTLTDVQVKGYTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDESKKSTM 1302 AP R + + GY + AG +++ +A++ + E++E P F P R+ ++ Sbjct: 352 PAPLTARVAAQPLTIGGYRVEAGTRIVVHIIAINRSAEVYEHPHEFRPERFLGTRPQTYA 411 Query: 1303 LKNFMPFGGGIRLCVGAEFSRIQIALFLHTLVTKYRWKEIKGGEVQRISEIVFPEGYHIQ 1482 ++PFGGG++ C+GA FS ++ LH L+ + + + E +RI I Sbjct: 412 ---WVPFGGGVKRCLGANFSMRELITVLHVLLREGEFTAV-DDEPERIVR------RSIM 461 Query: 1483 IIPREG 1500 ++PR G Sbjct: 462 LVPRRG 467
>Q9V773:C6A20_DROME Probable cytochrome P450 6a20 - Drosophila melanogaster (Fruit fly)| Length = 501 Score = 83.6 bits (205), Expect = 2e-15 Identities = 56/223 (25%), Positives = 111/223 (49%), Gaps = 7/223 (3%) Frame = +1 Query: 769 VLKDLLKERLGAPEKRHGDFLDEVVD-ELQSGRGVIDEKFAVDLMAALLF----ASFATV 933 +++D + R+ KRH DF+D +++ +L+ G + + +AA F A F T Sbjct: 252 IIRDTVDYRVKNNVKRH-DFVDMLIEMKLKFDNGDKENGLTFNEIAAQAFIFFLAGFETS 310 Query: 934 SSSLTIAMKFLSGHPNVVESLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISR 1113 S+++ A+ L+ H ++ + L+ E +LK+ + ++ + MT+ +V +E R Sbjct: 311 STTMGFALYELACHQDIQDKLRTEINTVLKQHN----GKLDYDSMREMTYLEKVIDETMR 366 Query: 1114 VSNVAPGIFRKTLTDVQVKG--YTIPAGWLVMISPMAVHLNPELFEDPLTFNPWRWQDES 1287 V + R Q Y I G V++ +A+H +PE + +P F P R+ ++ Sbjct: 367 KRPVVGHLIRVATQHYQHTNPKYNIEKGTGVIVPTLAIHHDPEFYPEPEKFIPERFDEDQ 426 Query: 1288 KKSTMLKNFMPFGGGIRLCVGAEFSRIQIALFLHTLVTKYRWK 1416 + F+PFG G R C+G F R+Q+ + + L+ ++++ Sbjct: 427 VQQRPACTFLPFGDGPRNCIGLRFGRMQVIVGMALLIHNFKFE 469
>O49340:C71AC_ARATH Cytochrome P450 71A12 - Arabidopsis thaliana (Mouse-ear cress)| Length = 497 Score = 83.2 bits (204), Expect = 3e-15 Identities = 106/449 (23%), Positives = 192/449 (42%), Gaps = 29/449 (6%) Frame = +1 Query: 169 LPPGSMGLPLVGETFQF-FKPSPSLDVPAFYKQRLKRYGPVFKTSLVGQPVVVSMDAEVN 345 LPP LPL+G Q P SL + RYGP+ P++V E Sbjct: 33 LPPSPWRLPLIGNLHQLSLHPHRSLHSLSL------RYGPLMLLHFGRVPILVVSSGEAA 86 Query: 346 RFIFQQEGKLFRSWYPDTANNIF---GKESIASYDGSFHKYVRSFA-------SRLFGLD 495 + + + F + A + G++ + G + + ++S + + Sbjct: 87 QEVLKTHDLKFANRPRSKAVHGLMNGGRDVVFGPYGEYWRQMKSVCILNLLTNKMVASFE 146 Query: 496 SLRDVLLAEMDCNVTDSLAAWAAEPAIEVKDAVANMVFDLTAKKLIG---FSPEKSRKLR 666 +R+ L EM + + ++ ++E + + + D+T++ +G E +R L+ Sbjct: 147 KIREEELNEMIKKLEKASSSSSSE---NLSELFVTLPSDVTSRIALGRKHSEDETARDLK 203 Query: 667 KNFDAFFQGLVSFPL--YFPGTTFYRCIQGR----KNVQKVLKDLL----KERLGAPEKR 816 K + L FP+ Y P + I G K V + DL+ +E L A + Sbjct: 204 KRVRQIMELLGEFPIGDYVPALAWIDRINGFNARIKEVSQGFSDLMDKVVQEHLEAGNHK 263 Query: 817 HGDFLDEVVD-ELQSGRGVIDEKFAVDLMAALLFASFATVSSSLTI-AMKFLSGHPNVVE 990 DF+D ++ E + G ++ + M +F + SS+L M L +PNV++ Sbjct: 264 E-DFVDILLSIESEKSIGFQAQRDDIKFMILDMFIGGTSTSSTLLEWIMTELIRNPNVMK 322 Query: 991 SLKEEHEAILKKREEGAKSGITWEEYKSMTFTAQVTNEISRVSNVAPGIFRKTLT-DVQV 1167 L++E + ++ K ++ ++M + V E+ RV P I + L+ DV+V Sbjct: 323 KLQDEIRSTIRPHGSYIKE----KDVENMKYLKAVIKEVFRVHPPLPLILPRLLSEDVKV 378 Query: 1168 KGYTIPAGWLVMISPMAVHLNPELF-EDPLTFNPWRWQDESKKSTMLK-NFMPFGGGIRL 1341 KGY I AG V+I+ A+ +P ++ D F P R D + NF+PFG G R+ Sbjct: 379 KGYNIAAGTEVIINAWAIQRDPAIWGPDAEEFKPERHLDSTLDYHGKDLNFIPFGSGRRI 438 Query: 1342 CVGAEFSRIQIALFLHTLVTKYRWKEIKG 1428 C G + + + + LV ++ W+ G Sbjct: 439 CPGINLALGLVEVTVANLVGRFDWRAEAG 467 Database: uniprot_sprot.fasta.out Posted date: Jul 19, 2007 5:58 PM Number of letters in database: 100,686,439 Number of sequences in database: 274,295 Lambda K H 0.318 0.134 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 274295 Number of Hits to DB: 328,255,332 Number of extensions: 7892063 Number of successful extensions: 25303 Number of sequences better than 10.0: 767 Number of HSP's gapped: 24501 Number of HSP's successfully gapped: 815 Length of query: 587 Length of database: 100,686,439 Length adjustment: 119 Effective length of query: 468 Effective length of database: 68,045,334 Effective search space: 31845216312 Effective search space used: 31845216312 Neighboring words threshold: 12 Window for multiple hits: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)
