Clone Name	FLbaf106j02
Clone Library Name	barley_pub

---

No.	Definition	Score (bits)	E Value
1	Q02158:PIPA_DICDI 1-phosphatidylinositol-4,5-bisphosphate phosph...	223	2e-57
2	Q8R3B1:PLCD1_MOUSE 1-phosphatidylinositol-4,5-bisphosphate phosp...	215	6e-55
3	P10688:PLCD1_RAT 1-phosphatidylinositol-4,5-bisphosphate phospho...	213	2e-54
4	P51178:PLCD1_HUMAN 1-phosphatidylinositol-4,5-bisphosphate phosp...	213	3e-54
5	P10895:PLCD1_BOVIN 1-phosphatidylinositol-4,5-bisphosphate phosp...	211	7e-54
6	Q15147:PLCB4_HUMAN 1-phosphatidylinositol-4,5-bisphosphate phosp...	209	3e-53
7	Q9QW07:PLCB4_RAT 1-phosphatidylinositol-4,5-bisphosphate phospho...	207	1e-52
8	Q07722:PLCB4_BOVIN 1-phosphatidylinositol-4,5-bisphosphate phosp...	206	3e-52
9	Q00722:PLCB2_HUMAN 1-phosphatidylinositol-4,5-bisphosphate phosp...	200	2e-50
10	P10687:PLCB1_RAT 1-phosphatidylinositol-4,5-bisphosphate phospho...	196	2e-49
11	Q9NQ66:PLCB1_HUMAN 1-phosphatidylinositol-4,5-bisphosphate phosp...	196	3e-49
12	P10894:PLCB1_BOVIN 1-phosphatidylinositol-4,5-bisphosphate phosp...	195	5e-49
13	P13217:PIPA_DROME 1-phosphatidylinositol-4,5-bisphosphate phosph...	195	5e-49
14	Q9Z1B3:PLCB1_MOUSE 1-phosphatidylinositol-4,5-bisphosphate phosp...	194	1e-48
15	O89040:PLCB2_RAT 1-phosphatidylinositol-4,5-bisphosphate phospho...	190	2e-47
16	Q8K394:PLCL2_MOUSE Inactive phospholipase C-like protein 2 - Mus...	187	2e-46
17	Q9UPR0:PLCL2_HUMAN Inactive phospholipase C-like protein 2 - Hom...	186	2e-46
18	Q01970:PLCB3_HUMAN 1-phosphatidylinositol-4,5-bisphosphate phosp...	186	4e-46
19	P51432:PLCB3_MOUSE 1-phosphatidylinositol-4,5-bisphosphate phosp...	184	2e-45
20	Q99JE6:PLCB3_RAT 1-phosphatidylinositol-4,5-bisphosphate phospho...	182	4e-45
21	P40977:PLC1_SCHPO 1-phosphatidylinositol-4,5-bisphosphate phosph...	153	3e-36
22	O13433:PLC1_CANAL 1-phosphatidylinositol-4,5-bisphosphate phosph...	138	7e-32
23	P25455:PIP1_DROME 1-phosphatidylinositol-4,5-bisphosphate phosph...	120	3e-26
24	P16885:PLCG2_HUMAN 1-phosphatidylinositol-4,5-bisphosphate phosp...	118	8e-26
25	O75038:PLCH2_HUMAN 1-phosphatidylinositol-4,5-bisphosphate phosp...	117	2e-25
26	P24135:PLCG2_RAT 1-phosphatidylinositol-4,5-bisphosphate phospho...	116	3e-25
27	P19174:PLCG1_HUMAN 1-phosphatidylinositol-4,5-bisphosphate phosp...	115	5e-25
28	P08487:PLCG1_BOVIN 1-phosphatidylinositol-4,5-bisphosphate phosp...	115	7e-25
29	Q62077:PLCG1_MOUSE 1-phosphatidylinositol-4,5-bisphosphate phosp...	115	9e-25
30	P32383:PLC1_YEAST 1-phosphatidylinositol-4,5-bisphosphate phosph...	114	1e-24
31	P10686:PLCG1_RAT 1-phosphatidylinositol-4,5-bisphosphate phospho...	112	6e-24
32	Q99P84:PLCE1_RAT 1-phosphatidylinositol-4,5-bisphosphate phospho...	103	3e-21
33	Q8K4S1:PLCE1_MOUSE 1-phosphatidylinositol-4,5-bisphosphate phosp...	101	1e-20
34	Q9P212:PLCE1_HUMAN 1-phosphatidylinositol-4,5-bisphosphate phosp...	100	2e-20
35	O43374:RASL2_HUMAN Ras GTPase-activating protein 4 - Homo sapien...	40	0.027
36	P28955:TEGU_EHV1B Large tegument protein - Equine herpesvirus 1 ...	38	0.18
37	Q62940:NEDD4_RAT E3 ubiquitin-protein ligase NEDD4 - Rattus norv...	38	0.18
38	Q5RBF2:NED4L_PONPY E3 ubiquitin-protein ligase NEDD4-like protei...	38	0.18
39	Q8CFI0:NED4L_MOUSE E3 ubiquitin-protein ligase NEDD4-like protei...	38	0.18
40	Q96PU5:NED4L_HUMAN E3 ubiquitin-protein ligase NEDD4-like protei...	38	0.18
41	P46935:NEDD4_MOUSE E3 ubiquitin-protein ligase NEDD4 - Mus muscu...	37	0.23
42	P46934:NEDD4_HUMAN E3 ubiquitin-protein ligase NEDD4 - Homo sapi...	37	0.40
43	O70556:SPR2E_MOUSE Small proline-rich protein 2E - Mus musculus ...	36	0.52
44	Q5RJH2:MCTP2_MOUSE Multiple C2 and transmembrane domain-containi...	36	0.52
45	O70558:SPR2G_MOUSE Small proline-rich protein 2G - Mus musculus ...	35	0.88
46	Q25378:KPC1_LYTPI Protein kinase C - Lytechinus pictus (Painted ...	35	0.88
47	Q9Z0R4:ITSN1_MOUSE Intersectin-1 - Mus musculus (Mouse)	35	0.88
48	Q15811:ITSN1_HUMAN Intersectin-1 - Homo sapiens (Human)	35	0.88
49	Q9SQV1:RH40_ARATH Probable DEAD-box ATP-dependent RNA helicase 4...	35	1.2
50	Q86XP0:PA24D_HUMAN Cytosolic phospholipase A2 delta - Homo sapie...	35	1.2
51	Q6DN12:MCTP2_HUMAN Multiple C2 and transmembrane domain-containi...	35	1.2
52	Q8NP40:IF2_CORGL Translation initiation factor IF-2 - Corynebact...	35	1.2
53	P40602:APG_ARATH Anter-specific proline-rich protein APG precurs...	35	1.5
54	P20444:KPCA_MOUSE Protein kinase C alpha type - Mus musculus (Mo...	35	1.5
55	O70557:SPR2F_MOUSE Small proline-rich protein 2F - Mus musculus ...	34	2.0
56	Q8TAI1:CR056_HUMAN Putative uncharacterized protein C18orf56 - H...	34	2.0
57	Q62746:SYT6_RAT Synaptotagmin-6 - Rattus norvegicus (Rat)	34	2.0
58	Q9R0N8:SYT6_MOUSE Synaptotagmin-6 - Mus musculus (Mouse)	34	2.0
59	Q5T7P8:SYT6_HUMAN Synaptotagmin-6 - Homo sapiens (Human)	34	2.0
60	P63319:KPCG_RAT Protein kinase C gamma type - Rattus norvegicus ...	34	2.0
61	P63318:KPCG_MOUSE Protein kinase C gamma type - Mus musculus (Mo...	34	2.0
62	O70555:SPR2D_MOUSE Small proline-rich protein 2D - Mus musculus ...	34	2.6
63	Q9ESD7:DYSF_MOUSE Dysferlin - Mus musculus (Mouse)	34	2.6
64	O14065:YC31_SCHPO Uncharacterized protein C962.01 - Schizosaccha...	33	3.4
65	Q8IV90:WASF4_HUMAN Wiskott-Aldrich syndrome protein family membe...	33	4.4
66	Q9UQ35:SRRM2_HUMAN Serine/arginine repetitive matrix protein 2 -...	33	4.4
67	P97868:RBBP6_MOUSE Retinoblastoma-binding protein 6 - Mus muscul...	33	4.4
68	Q7Z6E9:RBBP6_HUMAN Retinoblastoma-binding protein 6 - Homo sapie...	33	4.4
69	Q9M1G9:EXTN2_ARATH Extensin-2 precursor - Arabidopsis thaliana (...	33	4.4
70	P50764:VE1_HPV29 Replication protein E1 - Human papillomavirus t...	33	4.4
71	P10829:KPCG_RABIT Protein kinase C gamma type - Oryctolagus cuni...	33	4.4
72	Q4R4U2:KPCG_MACFA Protein kinase C gamma type - Macaca fascicula...	33	4.4
73	P05129:KPCG_HUMAN Protein kinase C gamma type - Homo sapiens (Hu...	33	4.4
74	P05128:KPCG_BOVIN Protein kinase C gamma type - Bos taurus (Bovine)	33	4.4
75	O75923:DYSF_HUMAN Dysferlin - Homo sapiens (Human)	33	4.4
76	O70554:SPR2B_MOUSE Small proline-rich protein 2B - Mus musculus ...	33	5.7
77	Q6PB44:PTN23_MOUSE Tyrosine-protein phosphatase non-receptor typ...	33	5.7
78	Q5T871:LELP1_HUMAN Late cornified envelope-like proline-rich pro...	33	5.7
79	P48733:UROM_BOVIN Uromodulin precursor - Bos taurus (Bovine)	33	5.7
80	Q62768:UN13A_RAT Unc-13 homolog A - Rattus norvegicus (Rat)	33	5.7
81	P49147:PA24A_CHICK Cytosolic phospholipase A2 - Gallus gallus (C...	33	5.7
82	Q9UMN6:WBP7_HUMAN WW domain-binding protein 7 - Homo sapiens (Hu...	32	7.5
83	Q1DS65:STU1_COCIM Protein STU1 - Coccidioides immitis	32	7.5
84	Q5ZMJ9:SRRM1_CHICK Serine/arginine repetitive matrix protein 1 -...	32	7.5
85	O88902:PTN23_RAT Tyrosine-protein phosphatase non-receptor type ...	32	7.5
86	P40603:APG_BRANA Anther-specific proline-rich protein APG - Bras...	32	7.5
87	O14795:UN13B_HUMAN Unc-13 homolog B - Homo sapiens (Human)	32	7.5
88	P05696:KPCA_RAT Protein kinase C alpha type - Rattus norvegicus ...	32	7.5
89	P10102:KPCA_RABIT Protein kinase C alpha type - Oryctolagus cuni...	32	7.5
90	P17252:KPCA_HUMAN Protein kinase C alpha type - Homo sapiens (Hu...	32	7.5
91	O70559:SPR2H_MOUSE Small proline-rich protein 2H - Mus musculus ...	32	9.7
92	Q38913:EXTN1_ARATH Extensin-1 precursor - Arabidopsis thaliana (...	32	9.7
93	Q62769:UN13B_RAT Unc-13 homolog B - Rattus norvegicus (Rat)	32	9.8
94	Q9Z1N9:UN13B_MOUSE Unc-13 homolog B - Mus musculus (Mouse)	32	9.8
95	Q9UPW8:UN13A_HUMAN Unc-13 homolog A - Homo sapiens (Human)	32	9.8
96	Q9Z268:RASL1_MOUSE RasGAP-activating-like protein 1 - Mus muscul...	32	9.8
97	Q9V427:INX2_DROME Innexin inx2 - Drosophila melanogaster (Fruit ...	32	9.8

---

>Q02158:PIPA_DICDI 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase -|
            Dictyostelium discoideum (Slime mold)
          Length = 801
 Score =  223 bits (568), Expect = 2e-57
 Identities = 153/509 (30%), Positives = 245/509 (48%), Gaps = 19/509 (3%)
 Frame = +2

Query: 335  FHRWLCSDANAALHPRRG-VHDDMGLPLSHYFIYTGHNSYLTGNQLSSGCSEVPIAKALR 511
            F  ++C +AN A +P    V+ D   PLS+YFI + HN+YL+G+QL    +       LR
Sbjct: 301  FEEFICGEANLAQYPHTSTVYQDTSKPLSYYFINSSHNTYLSGHQLKGLSTSEMYTNTLR 360

Query: 512  DGVRVIELDLWPNAAKDDVEVVHGRTWTSPVNLMKCLEAIKEHAFVSSPYPVILTLEDHL 691
             G + +ELD+W     D + + HG T TS +      E IK   F +SPYPVIL+LE H 
Sbjct: 361  QGCKCVELDVWDGNDGDPI-IFHGNTLTSQIKFSHVCETIKARGFETSPYPVILSLEVHC 419

Query: 692  TPHLQAKVAKMIKETFGDLLHLSDSEAMPVFPSPEDLRGKILISTKPPKEYLET------ 853
            +   Q  +A  +KE FG++L     E     P+ + L+ KIL+       ++        
Sbjct: 420  SVPQQIMMANHMKEIFGEMLPTPLPEGTKELPTLDSLKYKILLKGHTSHTHVSAVGNSSA 479

Query: 854  KTSKEEAQNGSTEEESVWG----DEIPDSKAQVSXXXXXXXXXXXXXXXXXGQLGVNEEY 1021
             +S+   Q    +++        DE+ D  A  S                  ++ +  E+
Sbjct: 480  SSSQSNIQTDDNDDDGAVDLTEYDEVDDRSASSSSSSFSLSFGSSGKKKKITKIKIAPEF 539

Query: 1022 KSLISIPLTRRKHDMDQDLKVDPEKVSRMSLGEAAYEKATITHGSEIIKFTQRNLLRIFP 1201
            + LI + ++      +   ++   K+   SL E   ++   +   E+++ +Q +LLR++P
Sbjct: 540  EELIYL-VSHGFKSGNTTKEIPSYKIH--SLVEEKVKQLVQSEPREVVEASQNHLLRVYP 596

Query: 1202 KTTRITSSNYNPLMGWTYGAQMVAANMQGHGRKLWLTQGMFRANGGCGYVKKPDFLMKTD 1381
            + TR  SSN++P+ GW+ G Q+ A N Q     +W+  GMF  NGGCGYV KP  L+  +
Sbjct: 597  RGTRFDSSNFDPMPGWSIGCQLAALNQQTSSEPMWINDGMFSDNGGCGYVLKPPCLLPGE 656

Query: 1382 -KMFDPRSELPVK----TRLKVTVYMGDGWRFDFRKTHFDKCSPPDFYARVGIAGVVADT 1546
             + +DP S   +K    +RL V V      R   + T   K    D Y  + I G   D 
Sbjct: 657  CETYDPTSPERIKSSKYSRLIVNVISA---RQLPKYTKSTKGEVIDPYVTLSIVGTHFDQ 713

Query: 1547 TMKETKVIKDN-WIPTWDQEFEFPLAVPELALLRVEVHESD--NHQKDDFAGQTCLPVWE 1717
             +++TKVI +N + P W +EFEFPL   +L++L + V + D   H +    G  C+ V  
Sbjct: 714  KVEKTKVIDNNGFNPHWGEEFEFPLYNSQLSMLLIRVDDKDKVGHNR---IGHHCIRVEN 770

Query: 1718 LRSGIRSVRLYARDGEVLRSVKLLMRFEF 1804
            +R G R ++L       +    LL +F F
Sbjct: 771  IRPGYRILKLKNNFNRTIPLANLLCKFTF 799

---

>Q8R3B1:PLCD1_MOUSE 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta 1 -|
            Mus musculus (Mouse)
          Length = 756

 Score =  215 bits (547), Expect = 6e-55
 Identities = 162/504 (32%), Positives = 248/504 (49%), Gaps = 21/504 (4%)
 Frame = +2

Query: 347  LCSDANAALHPRRGVHDDMGLPLSHYFIYTGHNSYLTGNQLSSGCSEVPIAKALRDGVRV 526
            L +D NA     R V+ DM  PLSHY + + HN+YL  +QL+   S     +AL  G R 
Sbjct: 280  LSADGNAFSLAHRRVYQDMNQPLSHYLVSSSHNTYLLEDQLTGPSSTEAYIRALCKGCRC 339

Query: 527  IELDLWPNAAKDDVEVVHGRTWTSPVNLMKCLEAIKEHAFVSSPYPVILTLEDHLTPHLQ 706
            +ELD W    ++ + + HG T+TS +     L AI+++AF +SPYPVIL+LE+H +   Q
Sbjct: 340  LELDCWDGPNQEPI-IYHGYTFTSKILFCDVLRAIRDYAFKASPYPVILSLENHCSLEQQ 398

Query: 707  AKVAKMIKETFGDLLHLSDSEAMPV-FPSPEDLRGKILISTKPPKEYLETKTSK-EEAQN 880
              +A  ++   G +L     + +    PSPE L+ KIL+  K     L        EA +
Sbjct: 399  RVMAHHLRAILGPMLLDQPLDGVTTSLPSPEQLKEKILLKGKKLGGLLPAGGENGPEATD 458

Query: 881  GSTEEESVWGDEIPDSKAQVSXXXXXXXXXXXXXXXXXGQLGVNEEYKSLISIPLTRRKH 1060
             S E+E+    E+ D   +                    Q+    +   L  +P      
Sbjct: 459  VSDEDEAA---EMEDEAVR-------------------SQVQHKPKEDKLKLVPEL---- 492

Query: 1061 DMDQDLKVDPEKV------SRMSLGEAAYEKATITH----------GSEIIKFTQRNLLR 1192
                D+ +  + V      S  + G+A YE A+ +           G+  ++    +L R
Sbjct: 493  ---SDMVIYCKSVHFGGFSSPSTSGQAFYEMASFSESRALRLLQESGNSFVRHNVGHLSR 549

Query: 1193 IFPKTTRITSSNYNPLMGWTYGAQMVAANMQGHGRKLWLTQGMFRANGGCGYVKKPDFLM 1372
            I+P   R  SSNY+P+  W  G Q+VA N Q  G ++ +  G F+ NGGCGYV KP FL 
Sbjct: 550  IYPAGWRTDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYLGCFQDNGGCGYVLKPAFLR 609

Query: 1373 KTDKMFDPR--SELPVKTRLKVTVYMGDGWRFDFRKTHFDKCSPPDFYARVGIAGVVADT 1546
              D  F+ R  ++ P     K+ V++  G +    K + +K S  D    V I GV  D 
Sbjct: 610  DPDTTFNSRALTQGPWWAPKKLRVWIISGQQLP--KVNKNKNSIVDPKVIVEIHGVGQDV 667

Query: 1547 TMKETKVIKDN-WIPTWDQEFEFPLAVPELALLRVEVHESDNHQKDDFAGQTCLPVWELR 1723
              ++T VI +N + P WD EFEF +AVP+LAL+R  V + D+  K+DF GQ+ +P   L+
Sbjct: 668  ASRQTAVITNNGFNPRWDTEFEFVVAVPDLALVRFMVEDYDSSSKNDFIGQSTIPWNSLK 727

Query: 1724 SGIRSVRLYARDGEVLRSVKLLMR 1795
             G R V L +++G++  S  L ++
Sbjct: 728  QGYRHVHLLSKNGDLHPSATLFVK 751

---

>P10688:PLCD1_RAT 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta 1 -|
            Rattus norvegicus (Rat)
          Length = 756

 Score =  213 bits (542), Expect = 2e-54
 Identities = 163/515 (31%), Positives = 248/515 (48%), Gaps = 32/515 (6%)
 Frame = +2

Query: 347  LCSDANAALHPRRGVHDDMGLPLSHYFIYTGHNSYLTGNQLSSGCSEVPIAKALRDGVRV 526
            L +D NA     R V+ DM  PLSHY + + HN+YL  +QL+   S     +AL  G R 
Sbjct: 280  LSADGNAFSLAHRRVYQDMDQPLSHYLVSSSHNTYLLEDQLTGPSSTEAYIRALCKGCRC 339

Query: 527  IELDLWPNAAKDDVEVVHGRTWTSPVNLMKCLEAIKEHAFVSSPYPVILTLEDHLTPHLQ 706
            +ELD W    ++ + + HG T+TS +     L AI+++AF +SPYPVIL+LE+H +   Q
Sbjct: 340  LELDCWDGPNQEPI-IYHGYTFTSKILFCDVLRAIRDYAFKASPYPVILSLENHCSLEQQ 398

Query: 707  AKVAKMIKETFGDLLHLSDSEAMPV-FPSPEDLRGKILISTKPPKEYLETKTSKEEAQNG 883
              +A+ ++   G +L     + +    PSPE L+GKIL+  K     L         +NG
Sbjct: 399  RVMARHLRAILGPILLDQPLDGVTTSLPSPEQLKGKILLKGKKLGGLLPAG-----GENG 453

Query: 884  STEEESVWGDEIPDSKAQVSXXXXXXXXXXXXXXXXXGQLGVNEEYKSLISIPLTRRKHD 1063
            S  E +   DE+  ++ +                        +E  +S +       +H 
Sbjct: 454  S--EATDVSDEVEAAEME------------------------DEAVRSQV-------QHK 480

Query: 1064 MDQD-LKVDPEKVSRM---------------SLGEAAYEKATITH----------GSEII 1165
              +D LK+ PE    +               + G+A YE A+ +           G+  +
Sbjct: 481  PKEDKLKLVPELSDMIIYCKSVHFGGFSSPGTSGQAFYEMASFSESRALRLLQESGNGFV 540

Query: 1166 KFTQRNLLRIFPKTTRITSSNYNPLMGWTYGAQMVAANMQGHGRKLWLTQGMFRANGGCG 1345
            +     L RI+P   R  SSNY+P+  W  G Q+VA N Q  G ++ +  G F+ NGGCG
Sbjct: 541  RHNVSCLSRIYPAGWRTDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYLGCFQDNGGCG 600

Query: 1346 YVKKPDFLMKTDKMFDPRSELP----VKTRLKVTVYMGDGWRFDFRKTHFDKCSPPDFYA 1513
            YV KP FL   +  F+ R+          RL+V +  G        K + +K S  D   
Sbjct: 601  YVLKPAFLRDPNTTFNSRALTQGPWWRPERLRVRIISGQ----QLPKVNKNKNSIVDPKV 656

Query: 1514 RVGIAGVVADTTMKETKVIKDN-WIPTWDQEFEFPLAVPELALLRVEVHESDNHQKDDFA 1690
             V I GV  DT  ++T VI +N + P WD EFEF + VP+LAL+R  V + D+  K+DF 
Sbjct: 657  IVEIHGVGRDTGSRQTAVITNNGFNPRWDMEFEFEVTVPDLALVRFMVEDYDSSSKNDFI 716

Query: 1691 GQTCLPVWELRSGIRSVRLYARDGEVLRSVKLLMR 1795
            GQ+ +P   L+ G R V L +++G+   S  L ++
Sbjct: 717  GQSTIPWNSLKQGYRHVHLLSKNGDQHPSATLFVK 751

---

>P51178:PLCD1_HUMAN 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta 1 -|
            Homo sapiens (Human)
          Length = 756

 Score =  213 bits (541), Expect = 3e-54
 Identities = 161/501 (32%), Positives = 241/501 (48%), Gaps = 18/501 (3%)
 Frame = +2

Query: 347  LCSDANAALHPRRGVHDDMGLPLSHYFIYTGHNSYLTGNQLSSGCSEVPIAKALRDGVRV 526
            L +D +A     R V+ DMG PLSHY + + HN+YL  +QL+   S     +AL  G R 
Sbjct: 280  LSADGSAFSLAHRRVYQDMGQPLSHYLVSSSHNTYLLEDQLAGPSSTEAYIRALCKGCRC 339

Query: 527  IELDLWPNAAKDDVEVVHGRTWTSPVNLMKCLEAIKEHAFVSSPYPVILTLEDHLTPHLQ 706
            +ELD W    ++ + + HG T+TS +     L AI+++AF +SPYPVIL+LE+H T   Q
Sbjct: 340  LELDCWDGPNQEPI-IYHGYTFTSKILFCDVLRAIRDYAFKASPYPVILSLENHCTLEQQ 398

Query: 707  AKVAKMIKETFGDLLHLSDSEAMP-VFPSPEDLRGKILISTKPPKEYLETK-TSKEEAQN 880
              +A+ +    G +L     + +    PSPE L+GKIL+  K     L        EA  
Sbjct: 399  RVMARHLHAILGPMLLNRPLDGVTNSLPSPEQLKGKILLKGKKLGGLLPPGGEGGPEATV 458

Query: 881  GSTEEESV-WGDEIPDSKAQVSXXXXXXXXXXXXXXXXXGQLGVNEEYKSLISIPLTRRK 1057
             S E+E+    DE   S+ Q                    +L + +E   ++     +  
Sbjct: 459  VSDEDEAAEMEDEAVRSRVQ--------------HKPKEDKLRLAQELSDMVIY--CKSV 502

Query: 1058 HDMDQDLKVDPEKVSRMSLGEAAYEKATITH----------GSEIIKFTQRNLLRIFPKT 1207
            H         P        G+A YE A+ +           G+  ++    +L RI+P  
Sbjct: 503  HFGGFSSPGTP--------GQAFYEMASFSENRALRLLQESGNGFVRHNVGHLSRIYPAG 554

Query: 1208 TRITSSNYNPLMGWTYGAQMVAANMQGHGRKLWLTQGMFRANGGCGYVKKPDFLMKTDKM 1387
             R  SSNY+P+  W  G Q+VA N Q  G ++ + Q  F+ NG CGYV KP FL   +  
Sbjct: 555  WRTDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYQDRFQDNGACGYVLKPAFLRDPNGT 614

Query: 1388 FDPRSELP----VKTRLKVTVYMGDGWRFDFRKTHFDKCSPPDFYARVGIAGVVADTTMK 1555
            F+PR+        + RL + V  G        K + +K S  D    V I GV  D   +
Sbjct: 615  FNPRALAQGPWWARKRLNIRVISGQ----QLPKVNKNKNSIVDPKVTVEIHGVSRDVASR 670

Query: 1556 ETKVIKDN-WIPTWDQEFEFPLAVPELALLRVEVHESDNHQKDDFAGQTCLPVWELRSGI 1732
            +T VI +N + P WD EF F + VP+LAL+R  V + D   K+DF GQ+ +P+  L+ G 
Sbjct: 671  QTAVITNNGFNPWWDTEFAFEVVVPDLALIRFLVEDYDASSKNDFIGQSTIPLNSLKQGY 730

Query: 1733 RSVRLYARDGEVLRSVKLLMR 1795
            R V L +++G+   S  L ++
Sbjct: 731  RHVHLMSKNGDQHPSATLFVK 751

---

>P10895:PLCD1_BOVIN 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta 1 -|
            Bos taurus (Bovine)
          Length = 695

 Score =  211 bits (538), Expect = 7e-54
 Identities = 157/507 (30%), Positives = 241/507 (47%), Gaps = 24/507 (4%)
 Frame = +2

Query: 347  LCSDANAALHPRRGVHDDMGLPLSHYFIYTGHNSYLTGNQLSSGCSEVPIAKALRDGVRV 526
            L +D +A     R V+ DM  PLSHY + + HN+YL  +QL+   S     +AL  G R 
Sbjct: 219  LSADGSAFDLADRRVYQDMDQPLSHYLVSSSHNTYLLEDQLTGPSSTEAYIRALCKGCRC 278

Query: 527  IELDLWPNAAKDDVEVVHGRTWTSPVNLMKCLEAIKEHAFVSSPYPVILTLEDHLTPHLQ 706
            +ELD W    ++ + + HG T+TS +     + AI+++AF +SPYPVIL+LE+H +   Q
Sbjct: 279  LELDCWDGPNQEPI-IYHGYTFTSKILFCDVVRAIRDYAFKASPYPVILSLENHCSLEQQ 337

Query: 707  AKVAKMIKETFGDLLHLSDSEAMPV-FPSPEDLRGKILISTK------PP--KEYLETKT 859
              +A+ ++   G +L     + +    PSPE LRGKIL+  K      PP  +   E   
Sbjct: 338  RVMARHLRTLLGPMLLDRPLDGVVTSLPSPEQLRGKILLKGKKLGGLFPPGGEGGPEATV 397

Query: 860  SKEEAQNGSTEEESVWGDEIPDSKAQVSXXXXXXXXXXXXXXXXXGQLGVNEEYKSLISI 1039
              +E +    E+E+V       SK                      +L + +E   ++  
Sbjct: 398  VSDEDEAAEMEDEAVRSQVQHKSKED--------------------KLRLAKELSDMVIY 437

Query: 1040 PLTRRKHDMDQDLKVDPEKVSRMSLGEAAYEKATITH----------GSEIIKFTQRNLL 1189
              +                 S  + G+A YE ++ +           G+  ++    +L 
Sbjct: 438  CKSVHFRGFP----------SSGTSGQAFYEMSSFSENRALRLLQESGNSFVRHNVNHLS 487

Query: 1190 RIFPKTTRITSSNYNPLMGWTYGAQMVAANMQGHGRKLWLTQGMFRANGGCGYVKKPDFL 1369
            RI+P   R  SSNY+P+  W  G Q+VA N Q  G ++ + QG F  NG CGYV KP FL
Sbjct: 488  RIYPAGWRTDSSNYSPVEMWNGGCQIVALNFQTPGSEMDVYQGRFLDNGACGYVLKPAFL 547

Query: 1370 MKTDKMFDPRSELP----VKTRLKVTVYMGDGWRFDFRKTHFDKCSPPDFYARVGIAGVV 1537
               +  F+ R+          RL V V  G        K + +K S  D    V I GV 
Sbjct: 548  RDPNSTFNSRALAHGPWWTPKRLNVRVISGQ----QLPKVNKNKNSIVDPKVTVEIHGVT 603

Query: 1538 ADTTMKETKVIKDN-WIPTWDQEFEFPLAVPELALLRVEVHESDNHQKDDFAGQTCLPVW 1714
             D   ++T V+ +N + P WD E EF +AVPELAL+R  V + D   K+DF GQ+ +P+ 
Sbjct: 604  GDVASRQTAVVTNNGFNPWWDTELEFEVAVPELALVRFVVEDYDASSKNDFIGQSTIPLK 663

Query: 1715 ELRSGIRSVRLYARDGEVLRSVKLLMR 1795
             L+ G R + L +++G+   S  L ++
Sbjct: 664  SLKQGYRHIHLLSKNGDQHPSATLFVK 690

---

>Q15147:PLCB4_HUMAN 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 -|
            Homo sapiens (Human)
          Length = 1175

 Score =  209 bits (532), Expect = 3e-53
 Identities = 160/522 (30%), Positives = 246/522 (47%), Gaps = 51/522 (9%)
 Frame = +2

Query: 335  FHRWLCSDANAALH-PRRGVHDDMGLPLSHYFIYTGHNSYLTGNQLSSGCSEVPIAKALR 511
            F R+L SD NA +   R  ++ +M  PL+HYFI + HN+YLTG Q     S     + L 
Sbjct: 292  FCRYLMSDENAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLL 351

Query: 512  DGVRVIELDLWPNAAKDDVEVV-HGRTWTSPVNLMKCLEAIKEHAFVSSPYPVILTLEDH 688
             G R +ELD W    +D   ++ HG+   + +     ++AIKE AFV+S YPVIL+ E+H
Sbjct: 352  AGCRCVELDCWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENH 411

Query: 689  LTPHLQAKVAKMIKETFGDLLHLSDSEAMPV-----FPSPEDLRGKILISTKPPKEYLET 853
             + + Q K++K  ++ FGDLL     E+ P+      PSP DL+ KILI  K  K  +E 
Sbjct: 412  CSKYQQYKMSKYCEDLFGDLLLKQALESHPLEPGRALPSPNDLKRKILIKNKRLKPEVEK 471

Query: 854  K-----------------------TSKEEAQNGSTEEES----VWGDEI-------PDSK 931
            K                        ++EE ++   EEE+     +G+E+        ++ 
Sbjct: 472  KQLEALRSMMEAGESASPANILEDDNEEEIESADQEEEAHPEFKFGNELSADDLGHKEAV 531

Query: 932  AQVSXXXXXXXXXXXXXXXXXGQLGVNEEYKSLISIPLTRRKHDMDQDLKVDPEK---VS 1102
            A                      +G        +S  +   +    Q   V  E+    +
Sbjct: 532  ANSVKKGLVTVEDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNIHYN 591

Query: 1103 RMSLGEAAYEKATITHGSEIIKFTQRNLLRIFPKTTRITSSNYNPLMGWTYGAQMVAANM 1282
              S  E+       TH  E + + +R + RI+PK  R+ SSNY P + W  G QMV+ N 
Sbjct: 592  MSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSLNY 651

Query: 1283 QGHGRKLWLTQGMFRANGGCGYVKKPDFLMKTDKMFDPRSELPVKTRLKVT--VYMGDGW 1456
            Q     + L QG F  NG CGY+ KPDF+ + D+ FDP SE PV   +  T  V +  G 
Sbjct: 652  QTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVISGQ 711

Query: 1457 RFDFRKTHFDKCSPPDFYARVGIAGVVADTTMKE--TKVIKDNWI-PTWDQE-FEF-PLA 1621
                +K           Y  V + G+  DT  KE  T+++ +N + P +++E F F  + 
Sbjct: 712  FLSDKKI--------GTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVI 763

Query: 1622 VPELALLRVEVHESDNHQKDDFAGQTCLPVWELRSGIRSVRL 1747
            +P+LA+LR+ V++ +N       GQ  LP+  L++G R + L
Sbjct: 764  LPDLAVLRIAVYDDNN----KLIGQRILPLDGLQAGYRHISL 801

---

>Q9QW07:PLCB4_RAT 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 -|
            Rattus norvegicus (Rat)
          Length = 1175

 Score =  207 bits (528), Expect = 1e-52
 Identities = 159/522 (30%), Positives = 246/522 (47%), Gaps = 51/522 (9%)
 Frame = +2

Query: 335  FHRWLCSDANAALH-PRRGVHDDMGLPLSHYFIYTGHNSYLTGNQLSSGCSEVPIAKALR 511
            F R+L SD NA +   R  ++ +M  PL+HYFI + HN+YLTG Q     S     + L 
Sbjct: 292  FCRYLMSDENAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLL 351

Query: 512  DGVRVIELDLWPNAAKDDVEVV-HGRTWTSPVNLMKCLEAIKEHAFVSSPYPVILTLEDH 688
             G R +ELD W    +D   ++ HG+   + +     ++AIKE AFV+S YPVIL+ E+H
Sbjct: 352  AGCRCVELDCWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENH 411

Query: 689  LTPHLQAKVAKMIKETFGDLLHLSDSEAMP-----VFPSPEDLRGKILISTKPPKEYLET 853
             + + Q +++K  ++ FGDLL     E+ P     + PSP DL+ KILI  K  K  +E 
Sbjct: 412  CSKYQQYQMSKYCEDLFGDLLLKQALESHPLEPGRLLPSPNDLKRKILIKNKRLKPEVEK 471

Query: 854  K-----------------------TSKEEAQNGSTEEES----VWGDEI-------PDSK 931
            K                        ++EE ++   EEE+     +G+E+        ++ 
Sbjct: 472  KQLEALKSMMEAGESAAPASILEDDNEEEIESADQEEEAHPEYKFGNELSADDFSHKEAV 531

Query: 932  AQVSXXXXXXXXXXXXXXXXXGQLGVNEEYKSLISIPLTRRKHDMDQDLKVDPEK---VS 1102
            A                      +G        +S  +   +    Q   V  E+    +
Sbjct: 532  ANSVKKGLVTVEDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNIHYN 591

Query: 1103 RMSLGEAAYEKATITHGSEIIKFTQRNLLRIFPKTTRITSSNYNPLMGWTYGAQMVAANM 1282
              S  E+       TH  E + + +R + RI+PK  R+ SSNY P + W  G QMV+ N 
Sbjct: 592  MSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSLNY 651

Query: 1283 QGHGRKLWLTQGMFRANGGCGYVKKPDFLMKTDKMFDPRSELPVKTRLKVT--VYMGDGW 1456
            Q     + L QG F  NG CGY+ KPDF+ + D+ FDP SE PV   +  T  V +  G 
Sbjct: 652  QTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVISGQ 711

Query: 1457 RFDFRKTHFDKCSPPDFYARVGIAGVVADTTMKE--TKVIKDNWI-PTWDQE-FEF-PLA 1621
                +K           Y  V + G+  DT  KE  T+++ +N + P +++E F F  + 
Sbjct: 712  FLSDKKI--------GTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVI 763

Query: 1622 VPELALLRVEVHESDNHQKDDFAGQTCLPVWELRSGIRSVRL 1747
            +P+LA+LR+ V++ +N       GQ  LP+  L++G R + L
Sbjct: 764  LPDLAVLRIAVYDDNN----KLIGQRILPLDGLQAGYRHISL 801

---

>Q07722:PLCB4_BOVIN 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 -|
            Bos taurus (Bovine)
          Length = 1023

 Score =  206 bits (524), Expect = 3e-52
 Identities = 165/534 (30%), Positives = 253/534 (47%), Gaps = 63/534 (11%)
 Frame = +2

Query: 335  FHRWLCSDANAALH-PRRGVHDDMGLPLSHYFIYTGHNSYLTGNQLSSGCSEVPIAKALR 511
            F R+L SD NA +   R  ++ +M  PL+HYFI + HN+YLTG Q     S     + L 
Sbjct: 128  FCRYLMSDENAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLL 187

Query: 512  DGVRVIELDLWPNAAKDDVEVV-HGRTWTSPVNLMKCLEAIKEHAFVSSPYPVILTLEDH 688
             G R +ELD W    +D   ++ HG+   + +     ++AIKE AFV+S YPVIL+ E+H
Sbjct: 188  AGCRCVELDCWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENH 247

Query: 689  LTPHLQAKVAKMIKETFGDLLHLSDSEAMPV-----FPSPEDLRGKILI-----STKPPK 838
             + + Q K++K  ++ FGDLL     E+ P+      PSP DL+ KILI      T+  K
Sbjct: 248  CSKYQQYKMSKYCEDLFGDLLLKQALESHPLEPGRPLPSPNDLKRKILIKKQTTETEVEK 307

Query: 839  EYLETKTS------------------KEEAQNGSTEEES----VWGDEIP----DSKAQV 940
            + LE   S                  +EE ++   EEE+     +G+E+       K  +
Sbjct: 308  KQLEALKSMMEAGESAAPVNMLEDDNEEEIESAEQEEEAHPEYKYGNELSADDLGHKEAI 367

Query: 941  SXXXXXXXXXXXXXXXXXGQLGVNEE------YKSL---------ISIPLTRRKHDMDQD 1075
            +                 G + V +E      YK +         +S  +   +    Q 
Sbjct: 368  ANSVKKASDDLEHENSKKGLVTVEDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQG 427

Query: 1076 LKVDPEK---VSRMSLGEAAYEKATITHGSEIIKFTQRNLLRIFPKTTRITSSNYNPLMG 1246
              V  E+    +  S  E+       TH  E + + +R + RI+PK  R+ SSNY P + 
Sbjct: 428  FHVAEERNIHYNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIF 487

Query: 1247 WTYGAQMVAANMQGHGRKLWLTQGMFRANGGCGYVKKPDFLMKTDKMFDPRSELPVKTRL 1426
            W  G QMV+ N Q     + L QG F  NG CGY+ KPDF+ + D+ FDP SE PV   +
Sbjct: 488  WNSGCQMVSLNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVI 547

Query: 1427 KVT--VYMGDGWRFDFRKTHFDKCSPPDFYARVGIAGVVADTTMKE--TKVIKDNWI-PT 1591
              T  V +  G     +K           Y  V + G+  DT  KE  T+++ +N + P 
Sbjct: 548  AATCSVQVISGQFLSDKKI--------GTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPV 599

Query: 1592 WDQE-FEF-PLAVPELALLRVEVHESDNHQKDDFAGQTCLPVWELRSGIRSVRL 1747
            +++E F F  + +P+LA+LR+ V++ +N       GQ  LP+  L++G R + L
Sbjct: 600  YNEESFVFRKVILPDLAVLRIAVYDDNN----KLIGQRILPLDGLQAGYRHISL 649

---

>Q00722:PLCB2_HUMAN 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 2 -|
            Homo sapiens (Human)
          Length = 1181

 Score =  200 bits (508), Expect = 2e-50
 Identities = 170/549 (30%), Positives = 251/549 (45%), Gaps = 35/549 (6%)
 Frame = +2

Query: 344  WLCSDANAAL-HPRRGVHDDMGLPLSHYFIYTGHNSYLTGNQLSSGCSEVPIAKALRDGV 520
            +LC   N+ L   +  +H DM  PL+HYFI + HN+YLT  Q S   S     + L  G 
Sbjct: 294  FLCGPENSVLAQDKLLLHHDMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLLSGC 353

Query: 521  RVIELDLWPNAAKDDVEVV-HGRTWTSPVNLMKCLEAIKEHAFVSSPYPVILTLEDHL-T 694
            R +ELD W     D+  ++ HG T T+ +   + +EAI E AF +SPYP+IL+ E+H+ +
Sbjct: 354  RCVELDCWKGKPPDEEPIITHGFTMTTDIFFKEAIEAIAESAFKTSPYPIILSFENHVDS 413

Query: 695  PHLQAKVAKMIKETFGDLLHLSDSEAMPV-----FPSPEDLRGKILISTKPPKEYLETKT 859
            P  QAK+A+  +  FGD+L     E  P+      PSPEDLRGKILI  K  +    T +
Sbjct: 414  PRQQAKMAEYCRTIFGDMLLTEPLEKFPLKPGVPLPSPEDLRGKILIKNKKNQFSGPTSS 473

Query: 860  SKE---EAQNGS-TEEESVWG---------DEIPDSKAQVSXXXXXXXXXXXXXXXXXGQ 1000
            SK+   EA+  S     +VW          +E+ + + + S                   
Sbjct: 474  SKDTGGEAEGSSPPSAPAVWAGEEGTELEEEEVEEEEEEESGNLDEEEIKKMQSDEGTAG 533

Query: 1001 LGVN--EEYKSLISIPLTRRKHDMDQDLKVDPEKVSRMSLGEAAYE---KATITHGSEII 1165
            L V   EE  SL++     +    +   + +   V        AY+   KA++    + +
Sbjct: 534  LEVTAYEEMSSLVNYIQPTKFVSFEFSAQKNRSYVISSFTELKAYDLLSKASV----QFV 589

Query: 1166 KFTQRNLLRIFPKTTRITSSNYNPLMGWTYGAQMVAANMQGHGRKLWLTQGMFRANGGCG 1345
             + +R + RI+PK TR+ SSNY P M W  G QMVA N Q     +     +F  NG  G
Sbjct: 590  DYNKRQMSRIYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMAVFEFNGQSG 649

Query: 1346 YVKKPDFLMKTDKMFDP----RSELPVKTRLKVTVYMGDGWRFDFRKTHFDKCSPPDFYA 1513
            Y+ K +F+ + DK F+P    R ++ V T L +TV  G        +T          Y 
Sbjct: 650  YLLKHEFMRRPDKQFNPFSVDRIDVVVATTLSITVISGQFLSERSVRT----------YV 699

Query: 1514 RVGIAGVVADTTMK-ETKV--IKDNWIPTWDQE-FEF-PLAVPELALLRVEVHESDNHQK 1678
             V + G+  D   +  TK+    ++  P W +E F F  + +PELA LRV V E  N   
Sbjct: 700  EVELFGLPGDPKRRYRTKLSPSTNSINPVWKEEPFVFEKILMPELASLRVAVMEEGN--- 756

Query: 1679 DDFAGQTCLPVWELRSGIRSVRLYARDGEVLRSVKLLMRFEFS*RMELAGVSLLILAMLV 1858
              F G   +P+  L SG   + L++     L    L +  E    +  A   L      V
Sbjct: 757  -KFLGHRIIPINALNSGYHHLCLHSESNMPLTMPALFIFLEMKDYIPGAWADL-----TV 810

Query: 1859 ACVKRLKFF 1885
            A    +KFF
Sbjct: 811  ALANPIKFF 819

---

>P10687:PLCB1_RAT 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 1 -|
            Rattus norvegicus (Rat)
          Length = 1216

 Score =  196 bits (499), Expect = 2e-49
 Identities = 151/498 (30%), Positives = 231/498 (46%), Gaps = 27/498 (5%)
 Frame = +2

Query: 335  FHRWLCSDANAALHPRR-GVHDDMGLPLSHYFIYTGHNSYLTGNQLSSGCSEVPIAKALR 511
            F R+L  + N  + P +  +++DM  PLSHYFI + HN+YLT  QL+   S     + L 
Sbjct: 295  FMRYLSGEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLL 354

Query: 512  DGVRVIELDLWPN-AAKDDVEVVHGRTWTSPVNLMKCLEAIKEHAFVSSPYPVILTLEDH 688
             G R +ELD W    A+++  + HG T T+ ++  + +EAI E AF +SP+P++L+ E+H
Sbjct: 355  SGCRCVELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENH 414

Query: 689  L-TPHLQAKVAKMIKETFGDLLHLSDSEAMPV-----FPSPEDLRGKILISTKPPKEYLE 850
            + +P  QAK+A+  +  FGD L +   E  P+      PSP DL  KIL+  K       
Sbjct: 415  VDSPKQQAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKKSHKSS 474

Query: 851  TKTSK----EEAQNGSTEEESVWGDEIPDS-KAQVSXXXXXXXXXXXXXXXXXGQLG--- 1006
              + K    E+A N  ++  SV+    P + +A                    G  G   
Sbjct: 475  EGSGKKKLSEQASNTYSDSSSVFEPSSPGAGEADTESDDDDDDDDCKKSSMDEGTAGSEA 534

Query: 1007 -VNEEYKSLISIPLTRRKHDMDQDLKVDPEKVSRMSLGEAAYEKATITHGSEIIKFTQRN 1183
               EE  +L++  +   K +  +  K   +     S  E    +       E +++ +  
Sbjct: 535  MATEEMSNLVNY-IQPVKFESFETSKKRNKSFEMSSFVETKGLEQLTKSPVEFVEYNKMQ 593

Query: 1184 LLRIFPKTTRITSSNYNPLMGWTYGAQMVAANMQGHGRKLWLTQGMFRANGGCGYVKKPD 1363
            L RI+PK TR+ SSNY P + W  G QMVA N Q     + +  GM+  NG  GY  KP+
Sbjct: 594  LSRIYPKGTRVDSSNYMPQLFWNAGCQMVALNFQTVDLAMQINMGMYEYNGKSGYRLKPE 653

Query: 1364 FLMKTDKMFDPRSE----LPVKTRLKVTVYMGDGWRFDFRKTHFDKCSPPDFYARVGIAG 1531
            F+ + DK FDP +E      V   L V +  G           F        Y  V + G
Sbjct: 654  FMRRPDKHFDPFTEGIVDGIVANTLSVKIISG----------QFLSDKKVGTYVEVDMFG 703

Query: 1532 VVADTTMK--ETKVIKDNWI-PTWDQE---FEFPLAVPELALLRVEVHESDNHQKDDFAG 1693
            +  DT  K  +TK  + N + P W++E   F+  + +P LA LR+  +E    +   F G
Sbjct: 704  LPVDTRRKAFKTKTSQGNAVNPVWEEEPIVFK-KVVLPSLACLRIAAYE----EGGKFIG 758

Query: 1694 QTCLPVWELRSGIRSVRL 1747
               LPV  +R G   + L
Sbjct: 759  HRILPVQAIRPGYHYICL 776

---

>Q9NQ66:PLCB1_HUMAN 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 1 -|
            Homo sapiens (Human)
          Length = 1216

 Score =  196 bits (498), Expect = 3e-49
 Identities = 151/498 (30%), Positives = 232/498 (46%), Gaps = 27/498 (5%)
 Frame = +2

Query: 335  FHRWLCSDANAALHPRR-GVHDDMGLPLSHYFIYTGHNSYLTGNQLSSGCSEVPIAKALR 511
            F R+L  + N  + P +  +++DM  PLSHYFI + HN+YLT  QL+   S     + L 
Sbjct: 295  FMRYLSGEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLL 354

Query: 512  DGVRVIELDLWPN-AAKDDVEVVHGRTWTSPVNLMKCLEAIKEHAFVSSPYPVILTLEDH 688
             G R +ELD W    A+++  + HG T T+ ++  + +EAI E AF +SP+P++L+ E+H
Sbjct: 355  SGCRCVELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENH 414

Query: 689  L-TPHLQAKVAKMIKETFGDLLHLSDSEAMPV-----FPSPEDLRGKILISTKPPKEYLE 850
            + +P  QAK+A+  +  FGD L +   E  P+      PSP DL  KIL+  K       
Sbjct: 415  VDSPKQQAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKKSHKSS 474

Query: 851  TKTSK----EEAQNGSTEEESVWGDEIPDS-KAQVSXXXXXXXXXXXXXXXXXGQLG--- 1006
              + K    E+A N  ++  S++    P + +A                    G  G   
Sbjct: 475  EGSGKKKLSEQASNTYSDSSSMFEPSSPGAGEADTESDDDDDDDDCKKSSMDEGTAGSEA 534

Query: 1007 -VNEEYKSLISIPLTRRKHDMDQDLKVDPEKVSRMSLGEAAYEKATITHGSEIIKFTQRN 1183
               EE  +L++  +   K +  +  K   +     S  E    +       E +++ +  
Sbjct: 535  MATEEMSNLVNY-IQPVKFESFEISKKRNKSFEMSSFVETKGLEQLTKSPVEFVEYNKMQ 593

Query: 1184 LLRIFPKTTRITSSNYNPLMGWTYGAQMVAANMQGHGRKLWLTQGMFRANGGCGYVKKPD 1363
            L RI+PK TR+ SSNY P + W  G QMVA N Q     + +  GM+  NG  GY  KP+
Sbjct: 594  LSRIYPKGTRVDSSNYMPQLFWNAGCQMVALNFQTMDLAMQINMGMYEYNGKSGYRLKPE 653

Query: 1364 FLMKTDKMFDPRSE----LPVKTRLKVTVYMGDGWRFDFRKTHFDKCSPPDFYARVGIAG 1531
            F+ + DK FDP +E      V   L V +  G           F        Y  V + G
Sbjct: 654  FMRRPDKHFDPFTEGIVDGIVANTLSVKIISG----------QFLSDKKVGTYVEVDMFG 703

Query: 1532 VVADTTMK--ETKVIKDNWI-PTWDQE---FEFPLAVPELALLRVEVHESDNHQKDDFAG 1693
            +  DT  K  +TK  + N + P W++E   F+  + +P LA LR+ V+E    +   F G
Sbjct: 704  LPVDTRRKAFKTKTSQGNAVNPVWEEEPIVFK-KVVLPTLACLRIAVYE----EGGKFIG 758

Query: 1694 QTCLPVWELRSGIRSVRL 1747
               LPV  +R G   + L
Sbjct: 759  HRILPVQAIRPGYHYICL 776

---

>P10894:PLCB1_BOVIN 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 1 -|
            Bos taurus (Bovine)
          Length = 1216

 Score =  195 bits (496), Expect = 5e-49
 Identities = 151/498 (30%), Positives = 231/498 (46%), Gaps = 27/498 (5%)
 Frame = +2

Query: 335  FHRWLCSDANAALHPRR-GVHDDMGLPLSHYFIYTGHNSYLTGNQLSSGCSEVPIAKALR 511
            F R+L  + N  + P +  +++DM  PLSHYFI + HN+YLT  QL+   S     + L 
Sbjct: 295  FMRYLSGEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLL 354

Query: 512  DGVRVIELDLWPN-AAKDDVEVVHGRTWTSPVNLMKCLEAIKEHAFVSSPYPVILTLEDH 688
             G R +ELD W    A+++  + HG T T+ ++  + +EAI E AF +SP+P++L+ E+H
Sbjct: 355  SGCRCVELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENH 414

Query: 689  L-TPHLQAKVAKMIKETFGDLLHLSDSEAMPV-----FPSPEDLRGKILISTKPPKEYLE 850
            + +P  QAK+A+  +  FGD L +   +  P+      PSP DL  KIL+  K       
Sbjct: 415  VDSPKQQAKMAEYCRLIFGDALLMEPLDKYPLESGVPLPSPMDLMYKILVKNKKKSHKSS 474

Query: 851  TKTSK----EEAQNGSTEEESVWGDEIPDS-KAQVSXXXXXXXXXXXXXXXXXGQLG--- 1006
              + K    E+A N  ++  SV+    P + +A                    G  G   
Sbjct: 475  EGSGKKKLSEQASNTYSDSSSVFEPSSPGAGEADTESDDDDDDDDCKKSSMDEGTAGSEA 534

Query: 1007 -VNEEYKSLISIPLTRRKHDMDQDLKVDPEKVSRMSLGEAAYEKATITHGSEIIKFTQRN 1183
               EE  +L++  +   K +  +  K         S  E    +       E +++ +  
Sbjct: 535  MATEEMSNLVNY-IQPVKFESFEISKKRNRSFEMSSFVETKGLEQLTKSPVEFVEYNKMQ 593

Query: 1184 LLRIFPKTTRITSSNYNPLMGWTYGAQMVAANMQGHGRKLWLTQGMFRANGGCGYVKKPD 1363
            L RI+PK TR+ SSNY P + W  G QMVA N Q     + +  GM+  NG  GY  KP+
Sbjct: 594  LSRIYPKGTRVDSSNYMPQLFWNAGCQMVALNFQTVDLAMQINMGMYEYNGKSGYRLKPE 653

Query: 1364 FLMKTDKMFDPRSE----LPVKTRLKVTVYMGDGWRFDFRKTHFDKCSPPDFYARVGIAG 1531
            F+ + DK FDP +E      V   L V +  G           F        Y  V + G
Sbjct: 654  FMRRPDKHFDPFTEGIVDGIVANTLSVKIISG----------QFLSDKKVGTYVEVDMFG 703

Query: 1532 VVADTTMK--ETKVIKDNWI-PTWDQE---FEFPLAVPELALLRVEVHESDNHQKDDFAG 1693
            +  DT  K  +TK  + N + P W++E   F+  + +P LA LR+ V+E    +   F G
Sbjct: 704  LPVDTRRKAFKTKTSQGNAVNPIWEEEPIVFK-KVVLPSLACLRIAVYE----EGGKFIG 758

Query: 1694 QTCLPVWELRSGIRSVRL 1747
               LPV  +R G   + L
Sbjct: 759  HRILPVQAIRPGYHYICL 776

---

>P13217:PIPA_DROME 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase -|
            Drosophila melanogaster (Fruit fly)
          Length = 1095

 Score =  195 bits (496), Expect = 5e-49
 Identities = 155/504 (30%), Positives = 235/504 (46%), Gaps = 33/504 (6%)
 Frame = +2

Query: 335  FHRWLCSDANAALH-PRRGVHDDMGLPLSHYFIYTGHNSYLTGNQLSSGCSEVPIAKALR 511
            F R+L SD NA +   R   + +M  PL+HY+I + HN+YL+G Q+    S     + L 
Sbjct: 298  FKRYLMSDENAPVFLDRLDFYMEMDQPLAHYYINSSHNTYLSGRQIGGKSSVEMYRQTLL 357

Query: 512  DGVRVIELDLWPNAAKDDVEVV-HGRTWTSPVNLMKCLEAIKEHAFVSSPYPVILTLEDH 688
             G R +ELD W    +D+  +V HG  + + +    C++AI + AFVSS YPVIL+ E+H
Sbjct: 358  AGCRCVELDCWNGKGEDEEPIVTHGHAYCTEILFKDCIQAIADCAFVSSEYPVILSFENH 417

Query: 689  LTPHLQAKVAKMIKETFGDLL---HLSDSEAMPVFPSPE--DLRGKILISTKPPKEYL-- 847
                 Q K+AK   + FGDLL    L D    P  P P    L+ KILI  K  K  +  
Sbjct: 418  CNRAQQYKLAKYCDDFFGDLLLKEPLPDHPLDPGLPLPPPCKLKRKILIKNKRMKPEVEK 477

Query: 848  ---------ETKTS---KEEAQNGSTEEESVWGDEIPDSKAQ---VSXXXXXXXXXXXXX 982
                     E KT    +E+A  G   E +      P++ A     +             
Sbjct: 478  VELELWLKGELKTDDDPEEDASAGKPPEAAAAPAPAPEAAAAAEGAAEGGGGAEAEAAAA 537

Query: 983  XXXXGQLGVNEEYKSLISIPLTRRKHDMDQDLKVDPEKVSRMSLGEAAYEKATITHGSEI 1162
                    V+    S+++     +    D+ ++ +    +  S  E+A          + 
Sbjct: 538  NYSGSTTNVHPWLSSMVNYAQPIKFQGFDKAIEKNIAH-NMSSFAESAGMNYLKQSSIDF 596

Query: 1163 IKFTQRNLLRIFPKTTRITSSNYNPLMGWTYGAQMVAANMQGHGRKLWLTQGMFRANGGC 1342
            + + +R + RI+PK TR  SSNY P + W  G QMV+ N Q     + L QG F  NGGC
Sbjct: 597  VNYNKRQMSRIYPKGTRADSSNYMPQVFWNAGCQMVSLNFQSSDLPMQLNQGKFEYNGGC 656

Query: 1343 GYVKKPDFLMKTDKMFDPRSELPV----KTRLKVTVYMGDGWRFDFRKTHFDKCSPPDFY 1510
            GY+ KPDF+ + DK FDP ++ PV      +  V V  G           F        Y
Sbjct: 657  GYLLKPDFMRRADKDFDPFADAPVDGVIAAQCSVKVIAG----------QFLSDKKVGTY 706

Query: 1511 ARVGIAGVVADTTMKE--TKVIKDNWI-PTWDQE-FEF-PLAVPELALLRVEVHESDNHQ 1675
              V + G+ +DT  KE  T+++ +N + P ++++ F F  + +P+LA+LR  V+E    +
Sbjct: 707  VEVDMFGLPSDTVKKEFRTRLVANNGLNPVYNEDPFVFRKVVLPDLAVLRFGVYE----E 762

Query: 1676 KDDFAGQTCLPVWELRSGIRSVRL 1747
                 GQ  LP+  L++G R V L
Sbjct: 763  SGKILGQRILPLDGLQAGYRHVSL 786

---

>Q9Z1B3:PLCB1_MOUSE 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 1 -|
            Mus musculus (Mouse)
          Length = 1216

 Score =  194 bits (492), Expect = 1e-48
 Identities = 150/498 (30%), Positives = 230/498 (46%), Gaps = 27/498 (5%)
 Frame = +2

Query: 335  FHRWLCSDANAALHPRR-GVHDDMGLPLSHYFIYTGHNSYLTGNQLSSGCSEVPIAKALR 511
            F R+L  + N  + P +  +++DM  PLSHYFI + HN+YLT  QL+   S     + L 
Sbjct: 295  FMRYLSGEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLL 354

Query: 512  DGVRVIELDLWPN-AAKDDVEVVHGRTWTSPVNLMKCLEAIKEHAFVSSPYPVILTLEDH 688
             G R +ELD W    A+++  + HG T T+ ++  + +EAI E AF +SP+P++L+ E+H
Sbjct: 355  SGCRCVELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENH 414

Query: 689  L-TPHLQAKVAKMIKETFGDLLHLSDSEAMPV-----FPSPEDLRGKILISTKPPKEYLE 850
            + +P  QAK+A+  +  FGD L +   E  P+      PSP DL  KIL+  K       
Sbjct: 415  VDSPKQQAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKKSHKSS 474

Query: 851  TKTSK----EEAQNGSTEEESVWGDEIPDS-KAQVSXXXXXXXXXXXXXXXXXGQLG--- 1006
              + K    E+A N  ++  SV+    P + +A                    G  G   
Sbjct: 475  EGSGKKKLSEQASNTYSDSSSVFEPSSPGAGEADTESDDDDDDDDCKKSSMDEGTAGSEA 534

Query: 1007 -VNEEYKSLISIPLTRRKHDMDQDLKVDPEKVSRMSLGEAAYEKATITHGSEIIKFTQRN 1183
               EE  +L++  +   K +  +  K   +     S  E    +       E +++ +  
Sbjct: 535  MATEEMSNLVNY-IQPVKFESFEISKKRNKSFEMSSFVETKGLEQLTKSPVEFVEYNKMQ 593

Query: 1184 LLRIFPKTTRITSSNYNPLMGWTYGAQMVAANMQGHGRKLWLTQGMFRANGGCGYVKKPD 1363
            L RI+PK TR+ SSNY P + W  G QM+A N Q     + +  GM+  NG  GY  KP+
Sbjct: 594  LSRIYPKGTRVDSSNYMPQLFWNAGCQMMALNFQTVDLAMQINMGMYEYNGKSGYRLKPE 653

Query: 1364 FLMKTDKMFDPRSE----LPVKTRLKVTVYMGDGWRFDFRKTHFDKCSPPDFYARVGIAG 1531
            F+ + DK FDP +E      V   L V +  G           F        Y  V + G
Sbjct: 654  FMRRPDKHFDPFTEGIVDGIVANTLSVKIISG----------QFLSDKKVGTYVEVDMFG 703

Query: 1532 VVADTTMK--ETKVIKDNWI-PTWDQE---FEFPLAVPELALLRVEVHESDNHQKDDFAG 1693
            +  DT  K   TK  + N + P W++E   F+  + +P LA LR+  +E    +   F G
Sbjct: 704  LPVDTRRKAFTTKTSQGNAVNPVWEEEPIVFK-KVVLPSLACLRIAAYE----EGGKFIG 758

Query: 1694 QTCLPVWELRSGIRSVRL 1747
               LPV  +R G   + L
Sbjct: 759  HRILPVQAIRPGYHYICL 776

---

>O89040:PLCB2_RAT 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 2 -|
            Rattus norvegicus (Rat)
          Length = 1183

 Score =  190 bits (482), Expect = 2e-47
 Identities = 158/529 (29%), Positives = 233/529 (44%), Gaps = 43/529 (8%)
 Frame = +2

Query: 344  WLCSDANAAL-HPRRGVHDDMGLPLSHYFIYTGHNSYLTGNQLSSGCSEVPIAKALRDGV 520
            +LC   N+ L H    +H DM  PL+HYFI + HN+YLT  Q S   S     + L  G 
Sbjct: 294  FLCGPENSVLAHDTLRIHQDMTQPLNHYFINSSHNTYLTAGQFSGPSSAEMYRQVLLSGC 353

Query: 521  RVIELDLWPNAAKDDVEVV-HGRTWTSPVNLMKCLEAIKEHAFVSSPYPVILTLEDHL-T 694
            R +ELD W     D+  ++ HG T T+ +   + +EAI E AF +SPYPVIL+ E+H+ +
Sbjct: 354  RCVELDCWKGKPPDEEPIITHGFTMTTDILFKEAVEAIAESAFKTSPYPVILSFENHVDS 413

Query: 695  PHLQAKVAKMIKETFGDLLHLSDSEAMPV-----FPSPEDLRGKILISTKPPKEYLETKT 859
            P  QAK+A+  +  FG+ L     E  P+      PSPEDLRGKILI  K  K       
Sbjct: 414  PRQQAKMAEYCRTMFGETLLTEPLENFPLKPGMPLPSPEDLRGKILIKNK--KNQFSGPA 471

Query: 860  SKEEAQNGSTE-----------------------EESVWGDEIPDSKAQVSXXXXXXXXX 970
            S  +  +G +E                       EE    +E+ + + + S         
Sbjct: 472  SPNKKPDGVSEGGFPSSVPVEEDTGWTAEDRTEVEEGEEEEEVEEEEEEESGNLDEEEIK 531

Query: 971  XXXXXXXXGQLGVN--EEYKSLISIPLTRRKHDMDQDLKVDPEKVSRMSLGEAAYEKATI 1144
                      L V   EE  SL++     +    +   + +   +        AYE  + 
Sbjct: 532  KMQSDEGTAGLEVTAYEEMSSLVNYIQPTKFISFEFSAQKNRSYLVSSFTELKAYELLS- 590

Query: 1145 THGSEIIKFTQRNLLRIFPKTTRITSSNYNPLMGWTYGAQMVAANMQGHGRKLWLTQGMF 1324
                + + + +R + R++PK TR+ SSNY P M W  G QMVA N Q     +     +F
Sbjct: 591  KASMQFVDYNKRQMSRVYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMALF 650

Query: 1325 RANGGCGYVKKPDFLMKTDKMFDP----RSELPVKTRLKVTVYMGDGWRFDFRKTHFDKC 1492
              NG  GY+ K +F+ + DK F+P    R ++ V T L +TV  G        +T     
Sbjct: 651  EFNGQSGYLLKHEFMRRQDKQFNPFSVDRIDVVVATTLSITVISGQFLSERSVRT----- 705

Query: 1493 SPPDFYARVGIAGVVADTTMK-ETKV--IKDNWIPTWDQE---FEFPLAVPELALLRVEV 1654
                 Y  V + G+  D   +  TK+    ++  P W +E   FE  + VPELA LR+ V
Sbjct: 706  -----YVEVELFGLPGDPKRRYRTKLSPTANSINPVWKEEPFIFE-KILVPELASLRIAV 759

Query: 1655 HESDNHQKDDFAGQTCLPVWELRSGIRSVRLYARDGEVLRSVKLLMRFE 1801
             E    +   F G   +P+  L SG   + L +     L    L +  E
Sbjct: 760  ME----EGGKFIGHRIIPINALHSGYHHLCLRSESNMPLTMPALFVFLE 804

---

>Q8K394:PLCL2_MOUSE Inactive phospholipase C-like protein 2 - Mus musculus (Mouse)|
          Length = 1128

 Score =  187 bits (474), Expect = 2e-46
 Identities = 140/472 (29%), Positives = 215/472 (45%), Gaps = 4/472 (0%)
 Frame = +2

Query: 389  VHDDMGLPLSHYFIYTGHNSYLTGNQLSSGCSEVPIAKALRDGVRVIELDLWPNAAKDDV 568
            V  DM  PLSHYFI + HN+YL  +Q           +AL+ G R +ELD+W     + V
Sbjct: 425  VCQDMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPV 484

Query: 569  EVVHGRTWTSPVNLMKCLEAIKEHAFVSSPYPVILTLEDHLTPHLQAKVAKMIKETFGDL 748
             +  G T TS +     ++ I ++AF +S YP+IL LE+H +   Q  + + +K+  GD 
Sbjct: 485  -IYTGHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKILGDK 543

Query: 749  LHLSDSEAMPVF-PSPEDLRGKILISTKPPKEYLETKTSKEEAQNGSTEEESVWGDEIPD 925
            L+ +       + PSP+ L+GKILI  K               ++   E     G E  +
Sbjct: 544  LYTTSPNMEESYLPSPDVLKGKILIKAKKLSSNCSGVEGDVTDEDEGAEMSQRMGKENVE 603

Query: 926  SKAQVSXXXXXXXXXXXXXXXXXGQLGVNEEYKSLISIPLTRRKHDMDQDLKVDPEKVSR 1105
                V                   +  + +E   L+SI  + +  +     +V  +    
Sbjct: 604  QPNHVPVK----------------RFQLCKELSELVSICKSVQFKEFQVSFQVQ-KYWEV 646

Query: 1106 MSLGEAAYEKATITHGSEIIKFTQRNLLRIFPKTTRITSSNYNPLMGWTYGAQMVAANMQ 1285
             S  E    K    +  + + + +R L R+FP   RI SSN NP   W  G Q+VA N Q
Sbjct: 647  CSFNEVLASKYANENPGDFVNYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQ 706

Query: 1286 GHGRKLWLTQGMFRANGGCGYVKKPDFLMKTDKMF--DPRSELPVKTRLKVTVYMGDGWR 1459
              G  + L  G FR NG CGYV +P  + +    F  + +  +P  +   + + +  G  
Sbjct: 707  TPGLMMDLNVGWFRQNGNCGYVLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQN 766

Query: 1460 FDFRKTHFDKCSPPDFYARVGIAGVVADTTMKETKVIKDNW-IPTWDQEFEFPLAVPELA 1636
            F   K    K    D Y  V I G+ AD   + TK +  N   P +D+ FEF + +PELA
Sbjct: 767  FPKPKGSGAKGDVVDPYVYVEIHGIPADCAEQRTKTVNQNGDAPIFDESFEFQINLPELA 826

Query: 1637 LLRVEVHESDNHQKDDFAGQTCLPVWELRSGIRSVRLYARDGEVLRSVKLLM 1792
            ++R  V + D++  D+F GQ  +P   L++G R V L +  GEVL    L +
Sbjct: 827  MVRFVVLD-DDYIGDEFIGQYTIPFECLQTGYRHVPLQSLTGEVLAHASLFV 877

---

>Q9UPR0:PLCL2_HUMAN Inactive phospholipase C-like protein 2 - Homo sapiens (Human)|
          Length = 1127

 Score =  186 bits (473), Expect = 2e-46
 Identities = 140/472 (29%), Positives = 215/472 (45%), Gaps = 4/472 (0%)
 Frame = +2

Query: 389  VHDDMGLPLSHYFIYTGHNSYLTGNQLSSGCSEVPIAKALRDGVRVIELDLWPNAAKDDV 568
            V  DM  PLSHYFI + HN+YL  +Q           +AL+ G R +ELD+W     + V
Sbjct: 424  VCQDMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPV 483

Query: 569  EVVHGRTWTSPVNLMKCLEAIKEHAFVSSPYPVILTLEDHLTPHLQAKVAKMIKETFGDL 748
             +  G T TS +     ++ I ++AF +S YP+IL LE+H +   Q  + + +K+  GD 
Sbjct: 484  -IYTGHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKLLGDK 542

Query: 749  LHLSDSEAMPVF-PSPEDLRGKILISTKPPKEYLETKTSKEEAQNGSTEEESVWGDEIPD 925
            L+ +       + PSP+ L+GKILI  K               ++   E     G E  +
Sbjct: 543  LYTTSPNVEESYLPSPDVLKGKILIKAKKLSSNCSGVEGDVTDEDEGAEMSQRMGKENME 602

Query: 926  SKAQVSXXXXXXXXXXXXXXXXXGQLGVNEEYKSLISIPLTRRKHDMDQDLKVDPEKVSR 1105
                V                   +  + +E   L+SI  + +  +     +V  +    
Sbjct: 603  QPNNVPVK----------------RFQLCKELSELVSICKSVQFKEFQVSFQVQ-KYWEV 645

Query: 1106 MSLGEAAYEKATITHGSEIIKFTQRNLLRIFPKTTRITSSNYNPLMGWTYGAQMVAANMQ 1285
             S  E    K    +  + + + +R L R+FP   RI SSN NP   W  G Q+VA N Q
Sbjct: 646  CSFNEVLASKYANENPGDFVNYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQ 705

Query: 1286 GHGRKLWLTQGMFRANGGCGYVKKPDFLMKTDKMF--DPRSELPVKTRLKVTVYMGDGWR 1459
              G  + L  G FR NG CGYV +P  + +    F  + +  +P  +   + + +  G  
Sbjct: 706  TPGLMMDLNIGWFRQNGNCGYVLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQN 765

Query: 1460 FDFRKTHFDKCSPPDFYARVGIAGVVADTTMKETKVIKDNW-IPTWDQEFEFPLAVPELA 1636
            F   K    K    D Y  V I G+ AD   + TK +  N   P +D+ FEF + +PELA
Sbjct: 766  FPKPKGSGAKGDVVDPYVYVEIHGIPADCAEQRTKTVHQNGDAPIFDESFEFQINLPELA 825

Query: 1637 LLRVEVHESDNHQKDDFAGQTCLPVWELRSGIRSVRLYARDGEVLRSVKLLM 1792
            ++R  V + D++  D+F GQ  +P   L++G R V L +  GEVL    L +
Sbjct: 826  MVRFVVLD-DDYIGDEFIGQYTIPFECLQTGYRHVPLQSLTGEVLAHASLFV 876

---

>Q01970:PLCB3_HUMAN 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 3 -|
            Homo sapiens (Human)
          Length = 1234

 Score =  186 bits (471), Expect = 4e-46
 Identities = 172/564 (30%), Positives = 244/564 (43%), Gaps = 73/564 (12%)
 Frame = +2

Query: 335  FHRWLCSDANAALHPRR-GVHDDMGLPLSHYFIYTGHNSYLTGNQLSSGCSEVPIAKALR 511
            F R+L  + N  L      +  DM  PLS YFI + HN+YLT  QL+   S     +AL 
Sbjct: 296  FSRYLGGEENGILPLEALDLSTDMTQPLSAYFINSSHNTYLTAGQLAGTSSVEMYRQALL 355

Query: 512  DGVRVIELDLWP-NAAKDDVEVVHGRTWTSPVNLMKCLEAIKEHAFVSSPYPVILTLEDH 688
             G R +ELD+W     +++  + HG T T+ V L   LEAI E AF +SPYPVIL+ E+H
Sbjct: 356  WGCRCVELDVWKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAETAFKTSPYPVILSFENH 415

Query: 689  L-TPHLQAKVAKMIKETFGDLLHLSDSEAMPV-----FPSPEDLRGKILISTKP------ 832
            + +   QAK+A+  +  FGD L +   +  P+      PSP+DL G+IL+  K       
Sbjct: 416  VDSAKQQAKMAEYCRSIFGDALLIEPLDKYPLAPGVPLPSPQDLMGRILVKNKKRHRPSA 475

Query: 833  -------PKEYLETKTSKEEAQNGSTEEES-VWGDEIPDSKAQVS-XXXXXXXXXXXXXX 985
                    K  LE   S     + +TE  S   G    DS   +S               
Sbjct: 476  GGPDSAGRKRPLEQSNSALSESSAATEPSSPQLGSPSSDSCPGLSNGEEVGLEKPSLEPQ 535

Query: 986  XXXGQLGVNEEYKSLISIPLTRRKHDMDQDLKVDPEKV-----SRMSLGEAAYEKATITH 1150
               G  G+N     L        + D +++ + DP+K      +  S   A  E +T+ +
Sbjct: 536  KSLGDEGLNRGPYVLGPADREDEEEDEEEEEQTDPKKPTTDEGTASSEVNATEEMSTLVN 595

Query: 1151 GSEIIKF-------------------------------------TQRNLLRIFPKTTRIT 1219
              E +KF                                      ++ L RI+PK TR+ 
Sbjct: 596  YIEPVKFKSFEAARKRNKCFEMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYPKGTRVD 655

Query: 1220 SSNYNPLMGWTYGAQMVAANMQGHGRKLWLTQGMFRANGGCGYVKKPDFLMKTDKMFDPR 1399
            SSNY P + W  G Q+VA N Q     + L  G+F  NG  GY+ KP+F+ + DK FDP 
Sbjct: 656  SSNYMPQLFWNVGCQLVALNFQTLDVAMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFDPF 715

Query: 1400 SEL----PVKTRLKVTVYMGDGWRFDFRKTHFDKCSPPDFYARVGIAGVVADTTMK-ETK 1564
            +E+     V   L+V V  G           F        Y  V + G+  DT  K  T+
Sbjct: 716  TEVIVDGIVANALRVKVISG----------QFLSDRKVGIYVEVDMFGLPVDTRRKYRTR 765

Query: 1565 VIKDN-WIPTWDQE-FEFP-LAVPELALLRVEVHESDNHQKDDFAGQTCLPVWELRSGIR 1735
              + N + P WD+E F+FP + +P LA LR+   E    +   F G   LPV  +RSG  
Sbjct: 766  TSQGNSFNPVWDEEPFDFPKVVLPTLASLRIAAFE----EGGKFVGHRILPVSAIRSGYH 821

Query: 1736 SVRLYARDGEVLRSVKLLMRFEFS 1807
             V L     + L    LL+  E S
Sbjct: 822  YVCLRNEANQPLCLPALLIYTEAS 845

---

>P51432:PLCB3_MOUSE 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 3 -|
            Mus musculus (Mouse)
          Length = 1234

 Score =  184 bits (466), Expect = 2e-45
 Identities = 174/569 (30%), Positives = 248/569 (43%), Gaps = 78/569 (13%)
 Frame = +2

Query: 335  FHRWLCSDANAALHPRR-GVHDDMGLPLSHYFIYTGHNSYLTGNQLSSGCSEVPIAKALR 511
            F R+L  + N  L      +  DM  PLS YFI + HN+YLT  QL+   S     +AL 
Sbjct: 296  FSRYLGGEENGILPLEALDLSMDMTQPLSAYFINSSHNTYLTAGQLAGPSSVEMYRQALL 355

Query: 512  DGVRVIELDLWP-NAAKDDVEVVHGRTWTSPVNLMKCLEAIKEHAFVSSPYPVILTLEDH 688
             G R +ELD+W     +++  + HG T T+ V L   LEAI E AF +SPYPVIL+ E+H
Sbjct: 356  WGCRCVELDVWKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAEAAFKTSPYPVILSFENH 415

Query: 689  L-TPHLQAKVAKMIKETFGDLLHLSDSEAMPV-----FPSPEDLRGKILISTKP------ 832
            + +   QAK+A+  +  FGD L +   +  P+      PSP+DL G+IL+  K       
Sbjct: 416  VDSAKQQAKMAEYCRSIFGDALLIDPLDKYPLSAGIPLPSPQDLMGRILVKNKKRHRPST 475

Query: 833  -------PKEYLETKTSKEEAQNGSTEEES-VWGDEIPDSKAQVSXXXXXXXXXXXXXXX 988
                    K  LE   S     + +TE  S   G    DS   +S               
Sbjct: 476  GVPDSSVRKRPLEQSNSALSESSAATEPSSPQLGSPSSDSCPGLSNGEEVGLEKTSLEP- 534

Query: 989  XXGQLGVNEEYKSL-ISIPLTRR-----KHDMDQDLKVDPEKV-----SRMSLGEAAYEK 1135
               Q  + EE  S   ++P+  R     + D +++   DP+K      +  S   A  E 
Sbjct: 535  ---QKSLGEESLSREPNVPMPDRDREDEEEDEEEEETTDPKKPTTDEGTASSEVNATEEM 591

Query: 1136 ATITHGSEIIKF-------------------------------------TQRNLLRIFPK 1204
            +T+ +  E +KF                                      ++ L RI+PK
Sbjct: 592  STLVNYVEPVKFKSFEASRKRNKCFEMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYPK 651

Query: 1205 TTRITSSNYNPLMGWTYGAQMVAANMQGHGRKLWLTQGMFRANGGCGYVKKPDFLMKTDK 1384
             TR+ SSNY P + W  G Q+VA N Q     + L  G+F  NG  GY+ KP+F+ + DK
Sbjct: 652  GTRVDSSNYMPQLFWNVGCQLVALNFQTLDLPMQLNAGVFEYNGRSGYLLKPEFMRRPDK 711

Query: 1385 MFDPRSEL----PVKTRLKVTVYMGDGWRFDFRKTHFDKCSPPDFYARVGIAGVVADTTM 1552
             FDP +E+     V   L+V V  G           F        Y  V + G+  DT  
Sbjct: 712  SFDPFTEVIVDGIVANALRVKVISG----------QFLSDKKVGIYVEVDMFGLPVDTRR 761

Query: 1553 K-ETKVIKDN-WIPTWDQE-FEFP-LAVPELALLRVEVHESDNHQKDDFAGQTCLPVWEL 1720
            K  T+  + N + P WD+E F+FP + +P LA LR+   E    +   F G   LPV  +
Sbjct: 762  KYRTRTSQGNSFNPVWDEEPFDFPKVVLPTLASLRIAAFE----EGGKFVGHRILPVSAI 817

Query: 1721 RSGIRSVRLYARDGEVLRSVKLLMRFEFS 1807
            RSG   V L     + L    LL+  E S
Sbjct: 818  RSGYHYVCLRNEANQPLCLPALLIYTEAS 846

---

>Q99JE6:PLCB3_RAT 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 3 -|
            Rattus norvegicus (Rat)
          Length = 1234

 Score =  182 bits (462), Expect = 4e-45
 Identities = 171/565 (30%), Positives = 244/565 (43%), Gaps = 74/565 (13%)
 Frame = +2

Query: 335  FHRWLCSDANAALHPRR-GVHDDMGLPLSHYFIYTGHNSYLTGNQLSSGCSEVPIAKALR 511
            F R+L  + N  L      +  DM  PLS YFI + HN+YLT  QL+   S     +AL 
Sbjct: 294  FSRYLGGEENGILPLEALDLSMDMTQPLSAYFINSSHNTYLTAGQLAGTSSVEMYRQALL 353

Query: 512  DGVRVIELDLWP-NAAKDDVEVVHGRTWTSPVNLMKCLEAIKEHAFVSSPYPVILTLEDH 688
             G R +ELD+W     +++  + HG T T+ V L   LEAI E AF +SPYPVIL+ E+H
Sbjct: 354  WGCRCVELDVWKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAETAFKTSPYPVILSFENH 413

Query: 689  L-TPHLQAKVAKMIKETFGDLLHLSDSEAMPV-----FPSPEDLRGKILISTKP------ 832
            + +   QAK+A+  +  FG+ L +   +  P+      PSP+DL G+IL+  K       
Sbjct: 414  VDSAKQQAKMAEYCRSIFGEALLIDPLDKYPLSAGTPLPSPQDLMGRILVKNKKRHRPST 473

Query: 833  -------PKEYLETKTSKEEAQNGSTEEES-VWGDEIPDSKAQVS-XXXXXXXXXXXXXX 985
                    K  LE   S     + +TE  S   G    DS   +S               
Sbjct: 474  GVPDSSVAKRPLEQSNSALSESSAATEPSSPQLGSPSSDSCPGLSNGEEVGLEKTSLEPQ 533

Query: 986  XXXGQLGVNEEYKSLI-SIPLTRRKHDMDQDLKVDPEKV-----SRMSLGEAAYEKATIT 1147
               G+ G+N     L+        + D +++   DP+K      +  S   A  E +T+ 
Sbjct: 534  KSLGEEGLNRGPNVLMPDRDREDEEEDEEEEETTDPKKPTTDEGTASSEVNATEEMSTLV 593

Query: 1148 HGSEIIKF-------------------------------------TQRNLLRIFPKTTRI 1216
            +  E +KF                                      ++ L RI+PK TR+
Sbjct: 594  NYVEPVKFKSFEASRKRNKCFEMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYPKGTRV 653

Query: 1217 TSSNYNPLMGWTYGAQMVAANMQGHGRKLWLTQGMFRANGGCGYVKKPDFLMKTDKMFDP 1396
             SSNY P + W  G Q+VA N Q     + L  G+F  NG  GY+ KP+F+ + DK FDP
Sbjct: 654  DSSNYMPQLFWNVGCQLVALNFQTLDLPMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFDP 713

Query: 1397 RSEL----PVKTRLKVTVYMGDGWRFDFRKTHFDKCSPPDFYARVGIAGVVADTTMK-ET 1561
             +E+     V   L+V V  G           F        Y  V + G+  DT  K  T
Sbjct: 714  FTEVIVDGIVANALRVKVISG----------QFLSDRKVGIYVEVDMFGLPVDTRRKYRT 763

Query: 1562 KVIKDN-WIPTWDQE-FEFP-LAVPELALLRVEVHESDNHQKDDFAGQTCLPVWELRSGI 1732
            +  + N + P WD+E F+FP + +P LA LR+   E        F G   LPV  +RSG 
Sbjct: 764  RTSQGNSFNPVWDEEPFDFPKVVLPTLASLRIAAFEEGGR----FVGHRILPVSAIRSGY 819

Query: 1733 RSVRLYARDGEVLRSVKLLMRFEFS 1807
              V L     + L    LL+  E S
Sbjct: 820  HYVCLRNEANQPLCLPALLIYTEAS 844

---

>P40977:PLC1_SCHPO 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase 1 -|
            Schizosaccharomyces pombe (Fission yeast)
          Length = 899

 Score =  153 bits (386), Expect = 3e-36
 Identities = 136/502 (27%), Positives = 214/502 (42%), Gaps = 13/502 (2%)
 Frame = +2

Query: 335  FHRWLCSDANAALHPRRGVHDDMGLPLSHYFIYTGHNSYLTGNQLSSGCSEVPIAKALRD 514
            F  +L S  N+ + P   V  DM  PL+ Y I + HN+YL G Q     S     ++L+ 
Sbjct: 424  FTSFLLSPHNSPVVP---VIQDMSRPLNEYLISSSHNTYLLGKQFGGESSIEGYIRSLQR 480

Query: 515  GVRVIELDLW--PNAAKDDVEVVHGRTWTSPVNLMKCLEAIKEHAFVSSPYPVILTLEDH 688
            G + IE+D W  PN       V HG T+TS +     ++AI+++AFV SPYP+ ++LE H
Sbjct: 481  GCKCIEIDCWDGPNGPV----VCHGHTFTSMIKFNDVIDAIRKYAFVVSPYPLFISLEIH 536

Query: 689  LTPHLQAKVAKMIKETFGDLLHLSDSEA-MPVFPSPEDLRGKILISTK---PPKEYLET- 853
              P  Q ++   +K+ FGD L +    A   V PSPEDL  KIL+  K    P     T 
Sbjct: 537  CCPDQQRQMVSYMKQAFGDTLVMKPVTANESVLPSPEDLLNKILLKVKCSATPLHQFSTD 596

Query: 854  --KTSKEEAQNGSTEEESVWGDEIPDSKAQVSXXXXXXXXXXXXXXXXXGQLGVNEEYKS 1027
              K    ++   +TE   +   E+   +                         + +E + 
Sbjct: 597  ILKVGITDSSTDTTESSELENSELTGLRKGKRRMKNI----------------IVQELQQ 640

Query: 1028 LISIPLTRRKHDMDQDLKVDPEKVSRMSLGEAAYEKATITHGSEIIKFTQRNLLRIFPKT 1207
            L   P  R     +  L          S  E   +K        + K   R L R++P  
Sbjct: 641  L--APYARSLKFRNFSLPESKTYSHIFSFSERTIKKHGKAMVPRLSKHNLRYLCRVYPGP 698

Query: 1208 TRITSSNYNPLMGWTYGAQMVAANMQGHGRKLWLTQGMFRANGGCGYVKKPDFLMKTDKM 1387
             R+ S+N+NP + W  G QMVA N Q +   L +   +F A+   GY+ KP    +    
Sbjct: 699  LRVGSTNFNPQVYWRLGVQMVALNWQTYDTGLQINDALFIADPPTGYLLKPP-CQRIIGT 757

Query: 1388 FDPRSELPVKTRLKVTVYMGDGWRFDFRKTHFDKCSPPDFYARVGIAGVVADTTMKETKV 1567
                  LP K +L + V  G   R     ++ +  SP   Y  + +  +        +KV
Sbjct: 758  TVGEEGLPRKIKLTIDVISGQQLRRARELSNSETLSP---YVEIQVHSMEESPFRWCSKV 814

Query: 1568 IKDN-WIPTWDQEFEFPLAVPE--LALLRVEVHESDNHQKDD-FAGQTCLPVWELRSGIR 1735
            + +N + P W +   +   + +   +++R  VH   ++  D  FA  TC P+  L+ G R
Sbjct: 815  VHENGFRPFWGETMVYESIISDDFYSMIRFLVHHRGSNGNDSIFANFTC-PIDRLQQGYR 873

Query: 1736 SVRLYARDGEVLRSVKLLMRFE 1801
             +RL    GE L    L ++ +
Sbjct: 874  HIRLLDMQGENLLFSSLFLKIK 895

---

>O13433:PLC1_CANAL 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase 1 - Candida|
            albicans (Yeast)
          Length = 1099

 Score =  138 bits (348), Expect = 7e-32
 Identities = 109/380 (28%), Positives = 168/380 (44%), Gaps = 27/380 (7%)
 Frame = +2

Query: 410  PLSHYFIYTGHNSYLTGNQLSSGCSEVPIAKALRDGVRVIELDLWPN----------AAK 559
            PL+ YFI + HN+YLTG Q++   S     + L+ G R +E+D+W              K
Sbjct: 569  PLNEYFISSSHNTYLTGRQVAGDSSVEGYIRTLQRGCRCVEIDIWNGDSNTTTTTVIGTK 628

Query: 560  DDVE-------VVHGRTWTSPVNLMKCLEAIKEHAFVSSPYPVILTLEDHLTPHLQAKVA 718
            DD +       V HGRT+T P++    + AIK+ AF+ SP+P+IL+LE H +P  Q KV 
Sbjct: 629  DDDDKNEYEPIVNHGRTFTKPISFANVIRAIKKFAFIVSPWPLILSLEIHCSPECQIKVV 688

Query: 719  KMIKETFGDLLHLSDSEA-MPVFPSPEDLRGKILISTKPPKEYLETKTSKEEAQNGSTEE 895
             ++K+  G+ + ++  +    + PSP +L+ K +I  K    +     +  E +NGS   
Sbjct: 689  NILKDILGENMIIAPIDIDSVILPSPAELKHKFIIKVKKTTSF----QNLIETENGSFTT 744

Query: 896  ESVWGDEIPDSKAQVSXXXXXXXXXXXXXXXXXGQLGVNEEYKSLISIPLTRRKHDMDQD 1075
             +        +    +                   +    + KS   I          Q 
Sbjct: 745  STTTTTTTTTTTTTATSLSEDNENNKSNSSSTSSFIIRRRKNKSPKIINELSNLGIYTQG 804

Query: 1076 LKVD----PEKVS---RMSLGEAAYEKATITHGSEII--KFTQRNLLRIFPKTTRITSSN 1228
            +K      PE  +     SLGE +  +       +I   K  +R L+R++P  TR+ SSN
Sbjct: 805  IKFRNFSLPESKTFNHCFSLGEKSINRMIKDDDKKISLDKHNRRYLMRVYPSGTRLKSSN 864

Query: 1229 YNPLMGWTYGAQMVAANMQGHGRKLWLTQGMFRANGGCGYVKKPDFLMKTDKMFDPRSEL 1408
            +NPL  W++G QMVA N Q +     L + +F      GYV KP  L K        S  
Sbjct: 865  FNPLPYWSHGVQMVATNWQTYDLGQQLNEALFENKIFQGYVLKPSVLRKPTL---KSSSS 921

Query: 1409 PVKTRLKVTVYMGDGWRFDF 1468
             V TR  +T       RF+F
Sbjct: 922  NVDTRTSLTTTNSKTIRFNF 941

---

>P25455:PIP1_DROME 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase classes I|
           and II - Drosophila melanogaster (Fruit fly)
          Length = 1318

 Score =  120 bits (300), Expect = 3e-26
 Identities = 70/171 (40%), Positives = 96/171 (56%), Gaps = 6/171 (3%)
 Frame = +2

Query: 335 FHRWLCSDANAALHPRR-GVHDDMGLPLSHYFIYTGHNSYLTGNQLSSGCSEVPIAKALR 511
           F R+L  D N  + P +  + DDM  P+SHYFI + HN+YLTG+QL+   S     + L 
Sbjct: 297 FLRYLMGDDNPIMAPSKLDLCDDMDQPMSHYFINSSHNTYLTGHQLTGKSSVEIYRQCLL 356

Query: 512 DGVRVIELDLWPNAAKDDVEVVHGRTWTSPVNLMKCLEAIKEHAFVSSPYPVILTLEDHL 691
            G R +ELD W N   ++  +VHG T+   +     LEAI E AF +S YPVIL+ E+H 
Sbjct: 357 AGCRCVELDFW-NGRTEEPVIVHGYTFVPEIFAKDVLEAIAESAFKTSEYPVILSFENHC 415

Query: 692 TPHLQAKVAKMIKETFGDLLHLSDSEAMPV-----FPSPEDLRGKILISTK 829
            P  QAK+A   +E FGD+L     ++ P+      P P  LR KI+I  K
Sbjct: 416 NPRQQAKIANYCREIFGDMLLDKPLDSHPLEPNMDLPPPAMLRRKIIIKNK 466



 Score = 92.4 bits (228), Expect = 6e-18
 Identities = 66/217 (30%), Positives = 104/217 (47%), Gaps = 5/217 (2%)
 Frame = +2

Query: 1157 EIIKFTQRNLLRIFPKTTRITSSNYNPLMGWTYGAQMVAANMQGHGRKLWLTQGMFRANG 1336
            E + + +  L R++P  TR  SSN+ P + W  G Q+VA N Q     + L  G+F  N 
Sbjct: 644  EFVNYNKHQLSRVYPAGTRFDSSNFMPQLFWNAGCQLVALNFQTLDLAMQLNLGIFEYNA 703

Query: 1337 GCGYVKKPDFLMKTDKMFDPRSELPVKTRLKVTVYMGDGWRFDFRKTHFDKCSPPDFYAR 1516
              GY+ KP+F+ ++D+  DP +E  V   +  TV              F      + +  
Sbjct: 704  RSGYLLKPEFMRRSDRRLDPFAESTVDGIIAGTV------SITVLSGQFLTDKRANTFVE 757

Query: 1517 VGIAGVVADTTMKE--TKVIKDNWI-PTWDQE-FEF-PLAVPELALLRVEVHESDNHQKD 1681
            V + G+ ADT  K+  TK ++DN + P +D+E F F  + +PELA +R+  +E    +  
Sbjct: 758  VDMYGLPADTVRKKFRTKTVRDNGMNPLYDEEPFVFKKVVLPELASIRIAAYE----EGG 813

Query: 1682 DFAGQTCLPVWELRSGIRSVRLYARDGEVLRSVKLLM 1792
               G   LPV  L  G R V L +  G+ +    L +
Sbjct: 814  KLIGHRVLPVIGLCPGYRHVNLRSEVGQPIALASLFL 850

---

>P16885:PLCG2_HUMAN 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 -|
           Homo sapiens (Human)
          Length = 1265

 Score =  118 bits (296), Expect = 8e-26
 Identities = 70/173 (40%), Positives = 98/173 (56%), Gaps = 3/173 (1%)
 Frame = +2

Query: 398 DMGLPLSHYFIYTGHNSYLTGNQLSSGCSEVPIAKALRDGVRVIELDLWPNAAKDDVEVV 577
           DM  PLSHY+I + HN+YLTG+QL S  S     + LR G R IELD W       V + 
Sbjct: 313 DMNNPLSHYWISSSHNTYLTGDQLRSESSPEAYIRCLRMGCRCIELDCWDGPDGKPV-IY 371

Query: 578 HGRTWTSPVNLMKCLEAIKEHAFVSSPYPVILTLEDHLTPHLQAKVAKMIKETFGDLLHL 757
           HG T T+ +     ++AIK+HAFV+S +PVIL++E+H +   Q  +AK  KE FGDLL  
Sbjct: 372 HGWTRTTKIKFDDVVQAIKDHAFVTSSFPVILSIEEHCSVEQQRHMAKAFKEVFGDLLLT 431

Query: 758 SDSEA-MPVFPSPEDLRGKILISTKP--PKEYLETKTSKEEAQNGSTEEESVW 907
             +EA     PSP  LR KI+I  K   P+  ++     ++ ++    E  +W
Sbjct: 432 KPTEASADQLPSPSQLREKIIIKHKKLGPRGDVDVNMEDKKDEHKQQGELYMW 484



 Score = 97.1 bits (240), Expect = 2e-19
 Identities = 69/214 (32%), Positives = 103/214 (48%), Gaps = 10/214 (4%)
 Frame = +2

Query: 1157 EIIKFTQRNLLRIFPKTTRITSSNYNPLMGWTYGAQMVAANMQGHGRKLWLTQGMFRANG 1336
            +++K+ Q+ L R++PK  R+ SSNY+P   W  G+QMVA N Q   + + +   +F  NG
Sbjct: 973  DLLKYNQKGLTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKYMQMNHALFSLNG 1032

Query: 1337 GCGYVKKPDFLMKTDKM--FDPRSELPVKTRLKVTVYMGDGWRFDFRKTHFDKCSPPDFY 1510
              GYV +P+  M+T+K     P S+  +   L V V    G R   +      C     +
Sbjct: 1033 RTGYVLQPE-SMRTEKYDPMPPESQRKILMTLTVKVL---GARHLPKLGRSIACP----F 1084

Query: 1511 ARVGIAGVVADTTMKETKVIKDN-----WIPTWDQEFEFPLAVPELALLRVEVHESDNHQ 1675
              V I G   D    +T V+ DN     W PT  ++  F +  P LA LR  V+E D   
Sbjct: 1085 VEVEICGAEYDNNKFKTTVVNDNGLSPIWAPT-QEKVTFEIYDPNLAFLRFVVYEEDMFS 1143

Query: 1676 KDDFAGQTCLPVWELRSGIRSVRL---YARDGEV 1768
              +F      P+  ++SG RSV L   Y+ D E+
Sbjct: 1144 DPNFLAHATYPIKAVKSGFRSVPLKNGYSEDIEL 1177

---

>O75038:PLCH2_HUMAN 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase eta 2 -|
            Homo sapiens (Human)
          Length = 1182

 Score =  117 bits (293), Expect = 2e-25
 Identities = 74/203 (36%), Positives = 109/203 (53%), Gaps = 5/203 (2%)
 Frame = +2

Query: 1154 SEIIKFTQRNLLRIFPKTTRITSSNYNPLMGWTYGAQMVAANMQGHGRKLWLTQGMFRAN 1333
            ++ ++F Q+ L RI+P + R+ SSNYNP   W  G QMVA N Q  GR L L +  F AN
Sbjct: 694  AQYLRFNQQQLSRIYPSSYRVDSSNYNPQPFWNAGCQMVALNYQSEGRMLQLNRAKFSAN 753

Query: 1334 GGCGYVKKPDFLMKTDKMFDPRSELP----VKTRLKVTVYMGDGWRFDFRKTHFDKCSPP 1501
            GGCGYV KP  + +   +F+P SE P    +K +L + +  G            D+    
Sbjct: 754  GGCGYVLKPGCMCQ--GVFNPNSEDPLPGQLKKQLVLRIISGQQLPKPRDSMLGDRGEII 811

Query: 1502 DFYARVGIAGVVADTTMKETKVIKDN-WIPTWDQEFEFPLAVPELALLRVEVHESDNHQK 1678
            D +  V I G+  D + ++T+V+ DN + PTW++   F + +PE+AL+R  V + D   +
Sbjct: 812  DPFVEVEIIGLPVDCSREQTRVVDDNGFNPTWEETLVFMVHMPEIALVRFLVWDHDPIGR 871

Query: 1679 DDFAGQTCLPVWELRSGIRSVRL 1747
             DF GQ  L    +  G R V L
Sbjct: 872  -DFIGQRTLAFSSMMPGYRHVYL 893



 Score =  114 bits (286), Expect = 1e-24
 Identities = 70/181 (38%), Positives = 101/181 (55%), Gaps = 2/181 (1%)
 Frame = +2

Query: 389 VHDDMGLPLSHYFIYTGHNSYLTGNQLSSGCSEVPIAKALRDGVRVIELDLWPNAAKDDV 568
           VH DM  PLSHYFI + HN+YL G+QL S       A  L+ G R +E+D W     + +
Sbjct: 350 VHQDMTQPLSHYFITSSHNTYLVGDQLMSQSRVDMYAWVLQAGCRCVEVDCWDGPDGEPI 409

Query: 569 EVVHGRTWTSPVNLMKCLEAIKEHAFVSSPYPVILTLEDHLTPHLQAKVAKMIKETFGDL 748
            V HG T TS +     +E I ++AF+ + YPVIL++E+H +   Q K+A+ + +  GD 
Sbjct: 410 -VHHGYTLTSKILFKDVIETINKYAFIKNEYPVILSIENHCSVIQQKKMAQYLTDILGDK 468

Query: 749 LHLS--DSEAMPVFPSPEDLRGKILISTKPPKEYLETKTSKEEAQNGSTEEESVWGDEIP 922
           L LS   SE     PSP+ L+GKIL+  K     L    S++  +   ++E+S   DEI 
Sbjct: 469 LDLSSVSSEDATTLPSPQMLKGKILVKGKK----LPANISEDAEEGEVSDEDS--ADEID 522

Query: 923 D 925
           D
Sbjct: 523 D 523

---

>P24135:PLCG2_RAT 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 -|
           Rattus norvegicus (Rat)
          Length = 1265

 Score =  116 bits (291), Expect = 3e-25
 Identities = 67/173 (38%), Positives = 99/173 (57%), Gaps = 3/173 (1%)
 Frame = +2

Query: 398 DMGLPLSHYFIYTGHNSYLTGNQLSSGCSEVPIAKALRDGVRVIELDLWPNAAKDDVEVV 577
           DM  PLSHY+I + HN+YLTG+QL S  S     + LR G R IELD W       + + 
Sbjct: 313 DMNNPLSHYWISSSHNTYLTGDQLRSESSTEAYIRCLRAGCRCIELDCWDGPDGKPI-IY 371

Query: 578 HGRTWTSPVNLMKCLEAIKEHAFVSSPYPVILTLEDHLTPHLQAKVAKMIKETFGDLLHL 757
           HG T T+ +     ++AI++HAFV+S +PVIL++E+H +   Q  +AK+ KE  GDLL  
Sbjct: 372 HGWTRTTKIKFDDVVQAIRDHAFVTSSFPVILSIEEHCSVEQQRHMAKVFKEVLGDLLLT 431

Query: 758 SDSEA-MPVFPSPEDLRGKILISTKP--PKEYLETKTSKEEAQNGSTEEESVW 907
             +EA     PSP  LR KI+I  K   P+  ++     ++ ++ +  E  +W
Sbjct: 432 KPTEASADQLPSPSQLREKIIIKHKKLGPRGDVDVNVEDKKDEHKTQGELYMW 484



 Score = 94.4 bits (233), Expect = 2e-18
 Identities = 67/214 (31%), Positives = 104/214 (48%), Gaps = 10/214 (4%)
 Frame = +2

Query: 1157 EIIKFTQRNLLRIFPKTTRITSSNYNPLMGWTYGAQMVAANMQGHGRKLWLTQGMFRANG 1336
            +++++ Q+ L R++PK  R+ SSNY+P   W  G+QMVA N Q   + + +   +F  NG
Sbjct: 973  DLLRYNQKGLTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTPDKYMQMNHALFSLNG 1032

Query: 1337 GCGYVKKPDFLMKTDKM--FDPRSELPVKTRLKVTVYMGDGWRFDFRKTHFDKCSPPDFY 1510
              GYV +P+  M+++K     P S+  +   L V V    G R   +      C     +
Sbjct: 1033 RTGYVLQPE-SMRSEKYDPMPPESQRKILMTLTVKVL---GARHLPKLGRSIACP----F 1084

Query: 1511 ARVGIAGVVADTTMKETKVIKDN-----WIPTWDQEFEFPLAVPELALLRVEVHESDNHQ 1675
              V I G   D+   +T V+ DN     W PT  ++  F +  P LA LR  V+E D   
Sbjct: 1085 VEVEICGAEYDSNKFKTTVVNDNGLSPVWAPT-QEKVTFEIYDPNLAFLRFLVYEEDMFS 1143

Query: 1676 KDDFAGQTCLPVWELRSGIRSVRL---YARDGEV 1768
              +F      P+  ++SG RSV L   Y+ D E+
Sbjct: 1144 DPNFLAHATYPIKGIKSGFRSVPLKNGYSEDIEL 1177

---

>P19174:PLCG1_HUMAN 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 -|
           Homo sapiens (Human)
          Length = 1290

 Score =  115 bits (289), Expect = 5e-25
 Identities = 73/167 (43%), Positives = 93/167 (55%), Gaps = 5/167 (2%)
 Frame = +2

Query: 395 DDMGLPLSHYFIYTGHNSYLTGNQLSSGCSEVPIAKALRDGVRVIELDLWPNAAKDDVEV 574
           D M  PLSHY+I + HN+YLTG+Q SS  S    A+ LR G R IELD W     D + V
Sbjct: 320 DTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMGCRCIELDCWDGP--DGMPV 377

Query: 575 V-HGRTWTSPVNLMKCLEAIKEHAFVSSPYPVILTLEDHLTPHLQAKVAKMIKETFGDLL 751
           + HG T T+ +     L  IKEHAFV+S YPVIL++EDH +   Q  +A+  K+  GD L
Sbjct: 378 IYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIAQQRNMAQYFKKVLGDTL 437

Query: 752 HLSDSE-AMPVFPSPEDLRGKILISTKPPKE---YLETKTSKEEAQN 880
                E +    PSP  L+ KILI  K   E   Y E  TS   ++N
Sbjct: 438 LTKPVEISADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSMMYSEN 484



 Score =  101 bits (251), Expect = 1e-20
 Identities = 65/219 (29%), Positives = 107/219 (48%), Gaps = 2/219 (0%)
 Frame = +2

Query: 1151 GSEIIKFTQRNLLRIFPKTTRITSSNYNPLMGWTYGAQMVAANMQGHGRKLWLTQGMFRA 1330
            G + +++ +  L RI+PK  R+ SSNY+PL  W  G+Q+VA N Q   + + + Q +F  
Sbjct: 997  GKKFLQYNRLQLSRIYPKGQRLDSSNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMT 1056

Query: 1331 NGGCGYVKKPDFLMKTDKMFDPRSELPVKTRLKVTVYMGDGWRFDFRKTHFDKCSPPDFY 1510
               CGYV +P  +   D+ FDP  +  ++      + +         K       P   +
Sbjct: 1057 GRHCGYVLQPSTM--RDEAFDPFDKSSLRGLEPCAISIEVLGARHLPKNGRGIVCP---F 1111

Query: 1511 ARVGIAGVVADTTMKETKVIKDNWI-PTWD-QEFEFPLAVPELALLRVEVHESDNHQKDD 1684
              + +AG   D+T ++T+ + DN + P W  + F F ++ PE A LR  V+E D     +
Sbjct: 1112 VEIEVAGAEYDSTKQKTEFVVDNGLNPVWPAKPFHFQISNPEFAFLRFVVYEEDMFSDQN 1171

Query: 1685 FAGQTCLPVWELRSGIRSVRLYARDGEVLRSVKLLMRFE 1801
            F  Q   PV  L++G R+V L     E L    LL++ +
Sbjct: 1172 FLAQATFPVKGLKTGYRAVPLKNNYSEDLELASLLIKID 1210

---

>P08487:PLCG1_BOVIN 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 -|
           Bos taurus (Bovine)
          Length = 1291

 Score =  115 bits (288), Expect = 7e-25
 Identities = 73/167 (43%), Positives = 93/167 (55%), Gaps = 5/167 (2%)
 Frame = +2

Query: 395 DDMGLPLSHYFIYTGHNSYLTGNQLSSGCSEVPIAKALRDGVRVIELDLWPNAAKDDVEV 574
           D M  PLSHY+I + HN+YLTG+Q SS  S    A+ LR G R IELD W     D + V
Sbjct: 320 DTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMGCRCIELDCWDGP--DGMPV 377

Query: 575 V-HGRTWTSPVNLMKCLEAIKEHAFVSSPYPVILTLEDHLTPHLQAKVAKMIKETFGDLL 751
           + HG T T+ +     L  IKEHAFV+S YPVIL++EDH +   Q  +A+  K+  GD L
Sbjct: 378 IYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIAQQRNMAQYFKKVLGDTL 437

Query: 752 HLSDSE-AMPVFPSPEDLRGKILISTKPPKE---YLETKTSKEEAQN 880
                + A    PSP  L+ KILI  K   E   Y E  TS   ++N
Sbjct: 438 LTKPVDIAADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSVMYSEN 484



 Score =  103 bits (257), Expect = 3e-21
 Identities = 66/219 (30%), Positives = 108/219 (49%), Gaps = 2/219 (0%)
 Frame = +2

Query: 1151 GSEIIKFTQRNLLRIFPKTTRITSSNYNPLMGWTYGAQMVAANMQGHGRKLWLTQGMFRA 1330
            G + +++ +  L RI+PK  R+ SSNY+PL  W  G+Q+VA N Q   + + + Q +F A
Sbjct: 997  GKKFLQYNRLQLSRIYPKGQRLDSSNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFLA 1056

Query: 1331 NGGCGYVKKPDFLMKTDKMFDPRSELPVKTRLKVTVYMGDGWRFDFRKTHFDKCSPPDFY 1510
             G CGYV +P  +   D+ FDP  +  ++      + +         K       P   +
Sbjct: 1057 GGHCGYVLQPSVM--RDEAFDPFDKSSLRGLEPCAICIEVLGARHLPKNGRGIVCP---F 1111

Query: 1511 ARVGIAGVVADTTMKETKVIKDNWI-PTWD-QEFEFPLAVPELALLRVEVHESDNHQKDD 1684
              + +AG   D+  ++T+ + DN + P W  + F F ++ PE A LR  V+E D     +
Sbjct: 1112 VEIEVAGAEYDSIKQKTEFVVDNGLNPVWPAKPFHFQISNPEFAFLRFVVYEEDMFSDQN 1171

Query: 1685 FAGQTCLPVWELRSGIRSVRLYARDGEVLRSVKLLMRFE 1801
            F  Q   PV  L++G R+V L     E L    LL++ +
Sbjct: 1172 FLAQATFPVKGLKTGYRAVPLKNNYSEGLELASLLVKID 1210

---

>Q62077:PLCG1_MOUSE 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 -|
           Mus musculus (Mouse)
          Length = 1302

 Score =  115 bits (287), Expect = 9e-25
 Identities = 73/167 (43%), Positives = 93/167 (55%), Gaps = 5/167 (2%)
 Frame = +2

Query: 395 DDMGLPLSHYFIYTGHNSYLTGNQLSSGCSEVPIAKALRDGVRVIELDLWPNAAKDDVEV 574
           D M  PLSHY+I + HN+YLTG+Q SS  S    A+ LR G R IELD W     D + V
Sbjct: 320 DTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMGCRCIELDCWD--GPDGMPV 377

Query: 575 V-HGRTWTSPVNLMKCLEAIKEHAFVSSPYPVILTLEDHLTPHLQAKVAKMIKETFGDLL 751
           + HG T T+ +     L  IKEHAFV+S YPVIL++EDH +   Q  +A+  ++  GD L
Sbjct: 378 IYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIAQQRNMAQHFRKVLGDTL 437

Query: 752 HLSDSE-AMPVFPSPEDLRGKILISTKPPKE---YLETKTSKEEAQN 880
                + A    PSP  LR KILI  K   E   Y E  TS   ++N
Sbjct: 438 LTKPVDIAADGLPSPNQLRRKILIKHKKLAEGSAYEEVPTSVMYSEN 484



 Score =  105 bits (263), Expect = 5e-22
 Identities = 67/219 (30%), Positives = 109/219 (49%), Gaps = 2/219 (0%)
 Frame = +2

Query: 1151 GSEIIKFTQRNLLRIFPKTTRITSSNYNPLMGWTYGAQMVAANMQGHGRKLWLTQGMFRA 1330
            G + +++ +  L RI+PK  R+ SSNY+PL  W  G+Q+VA N Q   + + + Q +F A
Sbjct: 997  GKKFLQYNRLQLSRIYPKGQRLDSSNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMA 1056

Query: 1331 NGGCGYVKKPDFLMKTDKMFDPRSELPVKTRLKVTVYMGDGWRFDFRKTHFDKCSPPDFY 1510
             G CGYV +P  +   D+ FDP  +  ++      + +         K       P   +
Sbjct: 1057 GGHCGYVLQPSTM--RDEAFDPFDKSSLRGLEPCVICIEVLGARHLPKNGRGIVCP---F 1111

Query: 1511 ARVGIAGVVADTTMKETKVIKDNWI-PTWD-QEFEFPLAVPELALLRVEVHESDNHQKDD 1684
              + +AG   D+T ++T+ + DN + P W  + F F ++ PE A LR  V+E D     +
Sbjct: 1112 VEIEVAGAEYDSTKQKTEFVVDNGLNPVWPAKPFHFQISNPEFAFLRFVVYEEDMFSDQN 1171

Query: 1685 FAGQTCLPVWELRSGIRSVRLYARDGEVLRSVKLLMRFE 1801
            F  Q   PV  L++G R+V L     E L    LL++ +
Sbjct: 1172 FLAQATFPVKGLKTGYRAVPLKNNYSEDLELASLLIKID 1210

---

>P32383:PLC1_YEAST 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase 1 -|
            Saccharomyces cerevisiae (Baker's yeast)
          Length = 869

 Score =  114 bits (286), Expect = 1e-24
 Identities = 116/496 (23%), Positives = 197/496 (39%), Gaps = 44/496 (8%)
 Frame = +2

Query: 410  PLSHYFIYTGHNSYLTGNQLSSGCSEVPIAKALRDGVRVIELDLWPNAAKDDVEVVHGRT 589
            PL+HYFI + HN+YL G Q++   S     + L+ G R +E+D+W    ++   V HG  
Sbjct: 385  PLNHYFIASSHNTYLLGKQIAETPSVEGYIQVLQQGCRCVEIDIWD--GENGPVVCHG-F 441

Query: 590  WTSPVNLMKCLEAIKEHAFVSSPYPVILTLEDHLTPHLQAKVAKMIKETFGDLLHLSDSE 769
             TS + L   +  IK++AF++SPYP+I++LE +     Q   + +++E   + L+   + 
Sbjct: 442  LTSAIPLKTVIRVIKKYAFITSPYPLIISLEINCNKDNQKLASLIMREVLAEQLYFVGTR 501

Query: 770  AMPVFPSPEDLRGKILISTKPPKEYLETKTSKE-------EAQNGSTEEESVWGDEIPDS 928
                 PSP +L+ KIL+ +K   E     +  E        +   + E+E    D+  +S
Sbjct: 502  T-DKLPSPRELKHKILLKSKKTSEATRGLSVNEPFPSSFSSSYESANEQELRMKDDSTNS 560

Query: 929  KAQVSXXXXXXXXXXXXXXXXXGQLGVNEEYKSLISIPLTRRKHDMD-QDLKVDPEKVSR 1105
             +  +                  ++G+ +    +  +      H +  ++  +   K   
Sbjct: 561  SSATNSSSMQRIK----------RIGLKKHADIINDVSNISGIHGIKFRNFSLPESKTIA 610

Query: 1106 --MSLGEAAYEKATITHGSEII--KFTQRNLLRIFPKTTRITSSNYNPLMGWTYGAQMVA 1273
               SL E   E        ++   K  +R L+R++P   R  SSN+NP+  W  G QMVA
Sbjct: 611  HCFSLNERKVEYMIKDKHLKLSLDKHNRRYLMRVYPHVLRYKSSNFNPIPFWKAGVQMVA 670

Query: 1274 ANMQGHGRKLWLTQGMFRANGGCGYVKKPDFLMKTDKMFDPRSELPVKTRLKVTVYMGDG 1453
             N Q +     L   MF+         +PD   K+  +  P+  LPV T+ K+   + + 
Sbjct: 671  TNWQTNDIGQQLNLAMFQI-----LDHQPDGSFKSGYVLKPKKLLPVVTKAKMIPLIYEH 725

Query: 1454 WR-------------------------------FDFRKTHFDKCSPPDFYARVGIAGVVA 1540
            +                                  F K  F     P     +   G   
Sbjct: 726  FENGSDPVTVKIRILSTQLLPRLNDTSPSRNNTNSFVKVEFHTDDEPTMPISID-KGTRI 784

Query: 1541 DTTMKETKVIKDN-WIPTWDQEFEFPLAVPELALLRVEVHESDNHQKDDFAGQTCLPVWE 1717
              T   TK  + N + P WD E    L   +L  ++  V   +           CL +  
Sbjct: 785  SATEASTKSSQGNGFNPIWDAEVSITLKDTDLTFIKFMVISEETQ-----IASVCLKLNY 839

Query: 1718 LRSGIRSVRLYARDGE 1765
            LR G R + L+  +GE
Sbjct: 840  LRMGYRHIPLFNMEGE 855

---

>P10686:PLCG1_RAT 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 -|
           Rattus norvegicus (Rat)
          Length = 1290

 Score =  112 bits (280), Expect = 6e-24
 Identities = 71/167 (42%), Positives = 93/167 (55%), Gaps = 5/167 (2%)
 Frame = +2

Query: 395 DDMGLPLSHYFIYTGHNSYLTGNQLSSGCSEVPIAKALRDGVRVIELDLWPNAAKDDVEV 574
           + M  PLSHY+I + HN+YLTG+Q SS  S    A+ LR G R IELD W     D + V
Sbjct: 320 ETMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMGCRCIELDCWDGP--DGMPV 377

Query: 575 V-HGRTWTSPVNLMKCLEAIKEHAFVSSPYPVILTLEDHLTPHLQAKVAKMIKETFGDLL 751
           + HG T T+ +     L  IKEHAFV+S YPVIL++EDH +   Q  +A+  ++  GD L
Sbjct: 378 IYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIAQQRNMAQHFRKVLGDTL 437

Query: 752 HLSDSE-AMPVFPSPEDLRGKILISTKPPKE---YLETKTSKEEAQN 880
                + A    PSP  L+ KILI  K   E   Y E  TS   ++N
Sbjct: 438 LTKPVDIAADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSVMYSEN 484



 Score =  105 bits (263), Expect = 5e-22
 Identities = 67/219 (30%), Positives = 109/219 (49%), Gaps = 2/219 (0%)
 Frame = +2

Query: 1151 GSEIIKFTQRNLLRIFPKTTRITSSNYNPLMGWTYGAQMVAANMQGHGRKLWLTQGMFRA 1330
            G + +++ +  L RI+PK  R+ SSNY+PL  W  G+Q+VA N Q   + + + Q +F A
Sbjct: 997  GKKFLQYNRLQLSRIYPKGQRLDSSNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMA 1056

Query: 1331 NGGCGYVKKPDFLMKTDKMFDPRSELPVKTRLKVTVYMGDGWRFDFRKTHFDKCSPPDFY 1510
             G CGYV +P  +   D+ FDP  +  ++      + +         K       P   +
Sbjct: 1057 GGHCGYVLQPSTM--RDEAFDPFDKSSLRGLEPCVICIEVLGARHLPKNGRGIVCP---F 1111

Query: 1511 ARVGIAGVVADTTMKETKVIKDNWI-PTWD-QEFEFPLAVPELALLRVEVHESDNHQKDD 1684
              + +AG   D+T ++T+ + DN + P W  + F F ++ PE A LR  V+E D     +
Sbjct: 1112 VEIEVAGAEYDSTKQKTEFVVDNGLNPVWPAKPFHFQISNPEFAFLRFVVYEEDMFSDQN 1171

Query: 1685 FAGQTCLPVWELRSGIRSVRLYARDGEVLRSVKLLMRFE 1801
            F  Q   PV  L++G R+V L     E L    LL++ +
Sbjct: 1172 FLAQATFPVKGLKTGYRAVPLKNNYSEDLELASLLIKID 1210

---

>Q99P84:PLCE1_RAT 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase epsilon 1 -|
            Rattus norvegicus (Rat)
          Length = 2281

 Score =  103 bits (256), Expect = 3e-21
 Identities = 57/155 (36%), Positives = 90/155 (58%), Gaps = 6/155 (3%)
 Frame = +2

Query: 398  DMGLPLSHYFIYTGHNSYLTGNQLSSGCSEVPIAKALRDGVRVIELDLWPNAAKDDVEVV 577
            D+ LPLS+Y+I + HN+YLTG+QL    S    ++ L  G R IELD W     D + ++
Sbjct: 1374 DLQLPLSYYYIESSHNTYLTGHQLKGESSVELYSQVLLQGCRSIELDCWD--GDDGMPII 1431

Query: 578  -HGRTWTSPVNLMKCLEAIKEHAFVSSPYPVILTLEDHLTPHLQAKVAKMIKETFGD--- 745
             HG T T+ +   + +EAI   AF++S  P+I+++E+H +   Q K+A++ K  FG+   
Sbjct: 1432 YHGHTLTTKIPFKEVVEAIDRSAFITSDLPIIISIENHCSLPQQRKMAEIFKSVFGEKLV 1491

Query: 746  --LLHLSDSEAMPVFPSPEDLRGKILISTKPPKEY 844
               L  +D    P+ PSP+ LR K+L+  K  K +
Sbjct: 1492 AKFLFETDFSDDPMLPSPDQLRRKVLLKNKKLKAH 1526



 Score = 94.4 bits (233), Expect = 2e-18
 Identities = 76/243 (31%), Positives = 110/243 (45%), Gaps = 6/243 (2%)
 Frame = +2

Query: 1109 SLGEAAYEKATITHGSEIIKFTQRNLLRIFPKTTRITSSNYNPLMGWTYGAQMVAANMQG 1288
            SL E A ++    +  ++I+ T   LLR +P  TRI SSN NPLM W +G Q+VA N Q 
Sbjct: 1738 SLNENAAKRLCRRYSQKLIQHTACQLLRTYPAATRIDSSNPNPLMFWLHGIQLVALNYQT 1797

Query: 1289 HGRKLWLTQGMFRANGGCGYVKKPDFLMKTD----KMFDP-RSELPVKTRLKVTVYMGDG 1453
                L L   MF ANGGCGYV KP  L        + F P   +L        ++ +  G
Sbjct: 1798 DDLPLHLNAAMFEANGGCGYVLKPPVLWDKSCPMYQKFSPLERDLDAMDPATYSLTIISG 1857

Query: 1454 WRFDFRKTHFDKCSPPDFYARVGIAGVVADTTMKETKVIKDNWI-PTWDQEFEFPLAVPE 1630
                   +    C        V + G+  D+    TK I  N + P W+++F F +   +
Sbjct: 1858 QNVCPSNSTGSPC------IEVDVLGMPLDSCHFRTKPIHRNTLNPMWNEQFLFRVHFED 1911

Query: 1631 LALLRVEVHESDNHQKDDFAGQTCLPVWELRSGIRSVRLYARDGEVLRSVKLLMRFEFS* 1810
            L  LR  V E+++        Q  +P+  L+ G R ++L     E+L    L +    S 
Sbjct: 1912 LVFLRFAVVENNS---SAITAQRIIPLKALKRGYRHLQLRNLHNEILEISSLFIN---SR 1965

Query: 1811 RME 1819
            RME
Sbjct: 1966 RME 1968

---

>Q8K4S1:PLCE1_MOUSE 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase epsilon 1 -|
            Mus musculus (Mouse)
          Length = 2282

 Score =  101 bits (252), Expect = 1e-20
 Identities = 56/155 (36%), Positives = 90/155 (58%), Gaps = 6/155 (3%)
 Frame = +2

Query: 398  DMGLPLSHYFIYTGHNSYLTGNQLSSGCSEVPIAKALRDGVRVIELDLWPNAAKDDVEVV 577
            ++ LPLS+Y+I + HN+YLTG+QL    S    ++ L  G R IELD W     D + ++
Sbjct: 1374 ELQLPLSYYYIESSHNTYLTGHQLKGESSVELYSQVLLQGCRSIELDCWD--GDDGMPII 1431

Query: 578  -HGRTWTSPVNLMKCLEAIKEHAFVSSPYPVILTLEDHLTPHLQAKVAKMIKETFGD--- 745
             HG T T+ +   + +EAI   AF++S  P+I+++E+H +   Q K+A++ K  FG+   
Sbjct: 1432 YHGHTLTTKIPFKEVVEAIDRSAFITSDLPIIISIENHCSLPQQRKMAEIFKSVFGEKLV 1491

Query: 746  --LLHLSDSEAMPVFPSPEDLRGKILISTKPPKEY 844
               L  +D    P+ PSP+ LR K+L+  K  K +
Sbjct: 1492 AKFLFETDFSDDPMLPSPDQLRRKVLLKNKKLKAH 1526



 Score = 92.0 bits (227), Expect = 8e-18
 Identities = 78/243 (32%), Positives = 111/243 (45%), Gaps = 6/243 (2%)
 Frame = +2

Query: 1109 SLGEAAYEKATITHGSEIIKFTQRNLLRIFPKTTRITSSNYNPLMGWTYGAQMVAANMQG 1288
            SL E A ++       ++I+ T   LLR +P  TRI SSN NP+M W +G Q+VA N Q 
Sbjct: 1739 SLNENAAKRLCRRGSQKLIQHTAYQLLRTYPAATRIDSSNPNPIMFWLHGIQLVALNYQT 1798

Query: 1289 HGRKLWLTQGMFRANGGCGYVKKPDFLM-KTDKMFDPRSELPVK-TRLKVTVY---MGDG 1453
                L L   MF ANGGCGYV KP  L  K+  M+   S L      L   +Y   +  G
Sbjct: 1799 DDLPLHLNAAMFEANGGCGYVLKPPVLWDKSCPMYQKFSPLERDLDNLDPAIYSLTIISG 1858

Query: 1454 WRFDFRKTHFDKCSPPDFYARVGIAGVVADTTMKETKVIKDNWI-PTWDQEFEFPLAVPE 1630
                   +    C        V + G+  D+    TK I  N + P W+++F F +   +
Sbjct: 1859 QNVCPSNSTGSPC------IEVDVLGMPLDSCHFRTKPIHRNTLNPMWNEQFLFRVHFED 1912

Query: 1631 LALLRVEVHESDNHQKDDFAGQTCLPVWELRSGIRSVRLYARDGEVLRSVKLLMRFEFS* 1810
            L  LR  V E+++        Q  +P+  L+ G R ++L     E+L    L +    S 
Sbjct: 1913 LVFLRFAVVENNS---SAITAQRIIPLRALKRGYRHLQLRNLHNEILEISSLFIN---SR 1966

Query: 1811 RME 1819
            RME
Sbjct: 1967 RME 1969

---

>Q9P212:PLCE1_HUMAN 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase epsilon 1 -|
            Homo sapiens (Human)
          Length = 2302

 Score =  100 bits (250), Expect = 2e-20
 Identities = 55/155 (35%), Positives = 90/155 (58%), Gaps = 6/155 (3%)
 Frame = +2

Query: 398  DMGLPLSHYFIYTGHNSYLTGNQLSSGCSEVPIAKALRDGVRVIELDLWPNAAKDDVEVV 577
            ++ LPLS+Y+I + HN+YLTG+QL    S    ++ L  G R +ELD W     D + ++
Sbjct: 1393 ELQLPLSYYYIESSHNTYLTGHQLKGESSVELYSQVLLQGCRSVELDCWD--GDDGMPII 1450

Query: 578  -HGRTWTSPVNLMKCLEAIKEHAFVSSPYPVILTLEDHLTPHLQAKVAKMIKETFGD--- 745
             HG T T+ +   + +EAI   AF++S  P+I+++E+H +   Q K+A++ K  FG+   
Sbjct: 1451 YHGHTLTTKIPFKEVVEAIDRSAFINSDLPIIISIENHCSLPQQRKMAEIFKTVFGEKLV 1510

Query: 746  --LLHLSDSEAMPVFPSPEDLRGKILISTKPPKEY 844
               L  +D    P+ PSP+ LR K+L+  K  K +
Sbjct: 1511 TKFLFETDFSDDPMLPSPDQLRKKVLLKNKKLKAH 1545



 Score = 92.0 bits (227), Expect = 8e-18
 Identities = 76/243 (31%), Positives = 110/243 (45%), Gaps = 6/243 (2%)
 Frame = +2

Query: 1109 SLGEAAYEKATITHGSEIIKFTQRNLLRIFPKTTRITSSNYNPLMGWTYGAQMVAANMQG 1288
            SL E A ++    +  ++ + T   LLR +P  TRI SSN NPLM W +G Q+VA N Q 
Sbjct: 1759 SLNENAAKRLCRRYSQKLTQHTACQLLRTYPAATRIDSSNPNPLMFWLHGIQLVALNYQT 1818

Query: 1289 HGRKLWLTQGMFRANGGCGYVKKPDFLMKTD----KMFDP-RSELPVKTRLKVTVYMGDG 1453
                L L   MF ANGGCGYV KP  L   +    + F P   +L        ++ +  G
Sbjct: 1819 DDLPLHLNAAMFEANGGCGYVLKPPVLWDKNCPMYQKFSPLERDLDSMDPAVYSLTIVSG 1878

Query: 1454 WRFDFRKTHFDKCSPPDFYARVGIAGVVADTTMKETKVIKDNWI-PTWDQEFEFPLAVPE 1630
                   +    C        V + G+  D+    TK I  N + P W+++F F +   +
Sbjct: 1879 QNVCPSNSMGSPC------IEVDVLGMPLDSCHFRTKPIHRNTLNPMWNEQFLFHVHFED 1932

Query: 1631 LALLRVEVHESDNHQKDDFAGQTCLPVWELRSGIRSVRLYARDGEVLRSVKLLMRFEFS* 1810
            L  LR  V E+++        Q  +P+  L+ G R ++L     EVL    L +    S 
Sbjct: 1933 LVFLRFAVVENNS---SAVTAQRIIPLKALKRGYRHLQLRNLHNEVLEISSLFIN---SR 1986

Query: 1811 RME 1819
            RME
Sbjct: 1987 RME 1989

---

>O43374:RASL2_HUMAN Ras GTPase-activating protein 4 - Homo sapiens (Human)|
          Length = 803

 Score = 40.4 bits (93), Expect = 0.027
 Identities = 24/80 (30%), Positives = 38/80 (47%)
 Frame = +2

Query: 1484 DKCSPPDFYARVGIAGVVADTTMKETKVIKDNWIPTWDQEFEFPLAVPELALLRVEVHES 1663
            D+    D + RV   G       +ET ++K +  P W++ FEF L    +  L VE  + 
Sbjct: 149  DRNGTSDPFVRVRYKG-----RTRETSIVKKSCYPRWNETFEFELQEGAMEALCVEAWDW 203

Query: 1664 DNHQKDDFAGQTCLPVWELR 1723
            D   ++DF G+  + V  LR
Sbjct: 204  DLVSRNDFLGKVVIDVQRLR 223

---

>P28955:TEGU_EHV1B Large tegument protein - Equine herpesvirus 1 (strain Ab4p) (EHV-1)|
            (Equine abortion virus)
          Length = 3421

 Score = 37.7 bits (86), Expect = 0.18
 Identities = 23/65 (35%), Positives = 35/65 (53%)
 Frame = +2

Query: 1112 LGEAAYEKATITHGSEIIKFTQRNLLRIFPKTTRITSSNYNPLMGWTYGAQMVAANMQGH 1291
            +GE A  K  +   SE+IK TQ+ + R+      +TS + NPL  +TY  + + A M  H
Sbjct: 560  VGELAVIKLELV-ASEVIKSTQKLVARVEELERDVTSGSVNPLGLYTYLTERLVAEMTKH 618

Query: 1292 GRKLW 1306
            G  L+
Sbjct: 619  GGDLF 623

---

>Q62940:NEDD4_RAT E3 ubiquitin-protein ligase NEDD4 - Rattus norvegicus (Rat)|
          Length = 887

 Score = 37.7 bits (86), Expect = 0.18
 Identities = 23/74 (31%), Positives = 40/74 (54%), Gaps = 1/74 (1%)
 Frame = +2

Query: 1502 DFYARVGIAGVVADT-TMKETKVIKDNWIPTWDQEFEFPLAVPELALLRVEVHESDNHQK 1678
            D Y RV +   ++   T  +TK IK +  P W++E  F + +P+   +  EV + +   +
Sbjct: 97   DPYVRVTLYDPMSGVLTSVQTKTIKKSLNPKWNEEILFRV-LPQQHRILFEVFDENRLTR 155

Query: 1679 DDFAGQTCLPVWEL 1720
            DDF GQ  +P++ L
Sbjct: 156  DDFLGQVDVPLYPL 169

---

>Q5RBF2:NED4L_PONPY E3 ubiquitin-protein ligase NEDD4-like protein - Pongo pygmaeus|
            (Orangutan)
          Length = 959

 Score = 37.7 bits (86), Expect = 0.18
 Identities = 29/99 (29%), Positives = 43/99 (43%)
 Frame = +2

Query: 1424 LKVTVYMGDGWRFDFRKTHFDKCSPPDFYARVGIAGVVADTTMKETKVIKDNWIPTWDQE 1603
            L+V V  G     D  K      S P     + +A    +  + +TK IK    P W++E
Sbjct: 26   LRVKVVSG----IDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLNPKWNEE 81

Query: 1604 FEFPLAVPELALLRVEVHESDNHQKDDFAGQTCLPVWEL 1720
            F F +  P    L  EV + +   +DDF GQ  +P+  L
Sbjct: 82   FYFRVN-PSNHRLLFEVFDENRLTRDDFLGQVDVPLSHL 119

---

>Q8CFI0:NED4L_MOUSE E3 ubiquitin-protein ligase NEDD4-like protein - Mus musculus (Mouse)|
          Length = 1004

 Score = 37.7 bits (86), Expect = 0.18
 Identities = 29/99 (29%), Positives = 43/99 (43%)
 Frame = +2

Query: 1424 LKVTVYMGDGWRFDFRKTHFDKCSPPDFYARVGIAGVVADTTMKETKVIKDNWIPTWDQE 1603
            L+V V  G     D  K      S P     + +A    +  + +TK IK    P W++E
Sbjct: 50   LRVKVVSG----IDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLNPKWNEE 105

Query: 1604 FEFPLAVPELALLRVEVHESDNHQKDDFAGQTCLPVWEL 1720
            F F +  P    L  EV + +   +DDF GQ  +P+  L
Sbjct: 106  FYFRVN-PSNHRLLFEVFDENRLTRDDFLGQVDVPLSHL 143

---

>Q96PU5:NED4L_HUMAN E3 ubiquitin-protein ligase NEDD4-like protein - Homo sapiens (Human)|
          Length = 975

 Score = 37.7 bits (86), Expect = 0.18
 Identities = 29/99 (29%), Positives = 43/99 (43%)
 Frame = +2

Query: 1424 LKVTVYMGDGWRFDFRKTHFDKCSPPDFYARVGIAGVVADTTMKETKVIKDNWIPTWDQE 1603
            L+V V  G     D  K      S P     + +A    +  + +TK IK    P W++E
Sbjct: 22   LRVKVVSG----IDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLNPKWNEE 77

Query: 1604 FEFPLAVPELALLRVEVHESDNHQKDDFAGQTCLPVWEL 1720
            F F +  P    L  EV + +   +DDF GQ  +P+  L
Sbjct: 78   FYFRVN-PSNHRLLFEVFDENRLTRDDFLGQVDVPLSHL 115

---

>P46935:NEDD4_MOUSE E3 ubiquitin-protein ligase NEDD4 - Mus musculus (Mouse)|
          Length = 887

 Score = 37.4 bits (85), Expect = 0.23
 Identities = 23/74 (31%), Positives = 40/74 (54%), Gaps = 1/74 (1%)
 Frame = +2

Query: 1502 DFYARVGIAGVVADT-TMKETKVIKDNWIPTWDQEFEFPLAVPELALLRVEVHESDNHQK 1678
            D Y RV +   ++   T  +TK IK +  P W++E  F + +P+   +  EV + +   +
Sbjct: 100  DPYVRVTLYDPMSGILTSVQTKTIKKSLNPKWNEEILFRV-LPQRHRILFEVFDENRLTR 158

Query: 1679 DDFAGQTCLPVWEL 1720
            DDF GQ  +P++ L
Sbjct: 159  DDFLGQVDVPLYPL 172

---

>P46934:NEDD4_HUMAN E3 ubiquitin-protein ligase NEDD4 - Homo sapiens (Human)|
          Length = 1000

 Score = 36.6 bits (83), Expect = 0.40
 Identities = 20/58 (34%), Positives = 32/58 (55%)
 Frame = +2

Query: 1547 TMKETKVIKDNWIPTWDQEFEFPLAVPELALLRVEVHESDNHQKDDFAGQTCLPVWEL 1720
            T  +TK IK +  P W++E  F +  P+   L  EV + +   +DDF GQ  +P++ L
Sbjct: 157  TSVQTKTIKKSLNPKWNEEILFRVH-PQQHRLLFEVFDENRLTRDDFLGQVDVPLYPL 213

---

>O70556:SPR2E_MOUSE Small proline-rich protein 2E - Mus musculus (Mouse)|
          Length = 76

 Score = 36.2 bits (82), Expect = 0.52
 Identities = 20/59 (33%), Positives = 24/59 (40%), Gaps = 12/59 (20%)
 Frame = -3

Query: 1007 PPIVPASPSLHPLPHTA--------RCPSLKPEPCCRGSH----PPTRSPPLCYHFGPP 867
            PP+ P      P PH          +CP   PEPC   S+    PP + PP C    PP
Sbjct: 15   PPVCPPKKCPEPCPHPQCPEPCPPPKCPEPCPEPCPPPSYQQKCPPVQPPPPCQQKCPP 73

---

>Q5RJH2:MCTP2_MOUSE Multiple C2 and transmembrane domain-containing protein 2 - Mus|
            musculus (Mouse)
          Length = 878

 Score = 36.2 bits (82), Expect = 0.52
 Identities = 30/107 (28%), Positives = 50/107 (46%)
 Frame = +2

Query: 1400 SELPVKTRLKVTVYMGDGWRFDFRKTHFDKCSPPDFYARVGIAGVVADTTMKETKVIKDN 1579
            S LP      +T+++ +G     R    D+C   D Y +  + G     T+ ++KVI  N
Sbjct: 186  SHLPSPFAYLLTIHLKEGRNLVVR----DRCGTSDPYVKFKLNG----KTLYKSKVIYKN 237

Query: 1580 WIPTWDQEFEFPLAVPELALLRVEVHESDNHQKDDFAGQTCLPVWEL 1720
              P WD+    P+   +   LRV+V++ D   K DF G   + + +L
Sbjct: 238  LNPIWDEIVVLPIQSLD-QKLRVKVYDRD-LTKSDFMGSAFVVLRDL 282



 Score = 35.4 bits (80), Expect = 0.88
 Identities = 18/58 (31%), Positives = 29/58 (50%)
 Frame = +2

Query: 1556 ETKVIKDNWIPTWDQEFEFPLAVPELALLRVEVHESDNHQKDDFAGQTCLPVWELRSG 1729
            +T  I  N  P W++ F FP+      +L V V + D  +  DF G+  +P+  +R G
Sbjct: 544  QTHTIYKNLNPEWNKVFTFPIKDIH-DVLEVTVFDEDGDKAPDFLGKVAIPLLSIRDG 600

---

>O70558:SPR2G_MOUSE Small proline-rich protein 2G - Mus musculus (Mouse)|
          Length = 76

 Score = 35.4 bits (80), Expect = 0.88
 Identities = 21/59 (35%), Positives = 26/59 (44%), Gaps = 12/59 (20%)
 Frame = -3

Query: 1007 PPIVPAS--PSLHPLPHTA------RCPSLKPEPC----CRGSHPPTRSPPLCYHFGPP 867
            PP+ P    P   PLP         +CP   PEPC    C+   PP ++PP C    PP
Sbjct: 15   PPVCPPPKCPEPCPLPKCPEPCPPPKCPEPCPEPCLPSPCQQKCPPVQTPPPCQQKCPP 73

---

>Q25378:KPC1_LYTPI Protein kinase C - Lytechinus pictus (Painted sea urchin)|
          Length = 658

 Score = 35.4 bits (80), Expect = 0.88
 Identities = 21/59 (35%), Positives = 30/59 (50%), Gaps = 1/59 (1%)
 Frame = +2

Query: 1547 TMKETKVIKDNWIPTWDQEFEFPLA-VPELALLRVEVHESDNHQKDDFAGQTCLPVWEL 1720
            T K+T+ IK +  PTW + F+F L        L VEV + D   ++DF G     + EL
Sbjct: 199  TKKKTRTIKGSLNPTWGESFDFNLEDTDRNRRLLVEVWDWDRATRNDFMGALSFGISEL 257

---

>Q9Z0R4:ITSN1_MOUSE Intersectin-1 - Mus musculus (Mouse)|
          Length = 1714

 Score = 35.4 bits (80), Expect = 0.88
 Identities = 18/55 (32%), Positives = 29/55 (52%)
 Frame = +2

Query: 1559 TKVIKDNWIPTWDQEFEFPLAVPELALLRVEVHESDNHQKDDFAGQTCLPVWELR 1723
            TK I+D   P W+   +F +   E  +L + V E D    DDF G+T + V +++
Sbjct: 1625 TKTIQDTLNPKWNSNCQFFIRDLEQEVLCITVFERDQFSPDDFLGRTEIRVADIK 1679

---

>Q15811:ITSN1_HUMAN Intersectin-1 - Homo sapiens (Human)|
          Length = 1721

 Score = 35.4 bits (80), Expect = 0.88
 Identities = 18/55 (32%), Positives = 29/55 (52%)
 Frame = +2

Query: 1559 TKVIKDNWIPTWDQEFEFPLAVPELALLRVEVHESDNHQKDDFAGQTCLPVWELR 1723
            TK I+D   P W+   +F +   E  +L + V E D    DDF G+T + V +++
Sbjct: 1632 TKTIQDTLNPKWNSNCQFFIRDLEQEVLCITVFERDQFSPDDFLGRTEIRVADIK 1686

---

>Q9SQV1:RH40_ARATH Probable DEAD-box ATP-dependent RNA helicase 40 - Arabidopsis|
            thaliana (Mouse-ear cress)
          Length = 1088

 Score = 35.0 bits (79), Expect = 1.2
 Identities = 28/77 (36%), Positives = 35/77 (45%), Gaps = 2/77 (2%)
 Frame = +1

Query: 796  GPQGQDPHIDQTSQRVP*NQDQQGGGPKW*HRG--GERVGG*DPRQQGSGFREGHRAVCG 969
            G  G  P   Q  + +    D  GGG +W   G  G R GG   R+ G G REG     G
Sbjct: 816  GGGGGGPGYSQDRRGMVNRFDSGGGGTRWDSGGGFGGRGGGFSGREGGFGGREG-----G 870

Query: 970  RG*RDGDAGTIGGQ*GV 1020
             G R+G  G  GG+ G+
Sbjct: 871  FGGREGGFGGRGGRFGM 887

---

>Q86XP0:PA24D_HUMAN Cytosolic phospholipase A2 delta - Homo sapiens (Human)|
          Length = 818

 Score = 35.0 bits (79), Expect = 1.2
 Identities = 26/106 (24%), Positives = 50/106 (47%), Gaps = 2/106 (1%)
 Frame = +2

Query: 1556 ETKVIKDNWIPTWDQEFEFPLAVPELALLRVEVHESDNHQKDDFAGQTCLPVWELRSG-- 1729
            +TK + D   P W++ F F +      +L + +++ D+  +DD   +    + E+  G  
Sbjct: 60   KTKTLTDTSHPVWNEAFRFLIQSQVKNVLELSIYDEDSVTEDDICFKVLYDISEVLPGKL 119

Query: 1730 IRSVRLYARDGEVLRSVKLLMRFEFS*RMELAGVSLLILAMLVACV 1867
            +R     +  GE    V+ LM  E S R E    + +I+A  ++C+
Sbjct: 120  LRKTFSQSPQGEEELDVEFLME-ETSDRPENLITNKVIVARELSCL 164

---

>Q6DN12:MCTP2_HUMAN Multiple C2 and transmembrane domain-containing protein 2 - Homo|
            sapiens (Human)
          Length = 878

 Score = 35.0 bits (79), Expect = 1.2
 Identities = 17/58 (29%), Positives = 29/58 (50%)
 Frame = +2

Query: 1556 ETKVIKDNWIPTWDQEFEFPLAVPELALLRVEVHESDNHQKDDFAGQTCLPVWELRSG 1729
            +T  +  N  P W++ F FP+      +L V V + D  +  DF G+  +P+  +R G
Sbjct: 544  QTHTVYKNLNPEWNKVFTFPIKDIH-DVLEVTVFDEDGDKPPDFLGKVAIPLLSIRDG 600



 Score = 34.7 bits (78), Expect = 1.5
 Identities = 26/92 (28%), Positives = 43/92 (46%)
 Frame = +2

Query: 1391 DPRSELPVKTRLKVTVYMGDGWRFDFRKTHFDKCSPPDFYARVGIAGVVADTTMKETKVI 1570
            D  S LP      +T+++ +G     R    D+C   D Y +  + G     T+ ++KVI
Sbjct: 183  DGLSNLPSPFAYLLTIHLKEGRNLVVR----DRCGTSDPYVKFKLNG----KTLYKSKVI 234

Query: 1571 KDNWIPTWDQEFEFPLAVPELALLRVEVHESD 1666
              N  P WD+    P+   +   LRV+V++ D
Sbjct: 235  YKNLNPVWDEIVVLPIQSLD-QKLRVKVYDRD 265

---

>Q8NP40:IF2_CORGL Translation initiation factor IF-2 - Corynebacterium glutamicum|
            (Brevibacterium flavum)
          Length = 1004

 Score = 35.0 bits (79), Expect = 1.2
 Identities = 34/93 (36%), Positives = 38/93 (40%), Gaps = 4/93 (4%)
 Frame = +1

Query: 865  GGGPKW*HRGGERVGG*DPRQQGSGFREGHRAVCGRG*RDGDAGTIGGQ*GV*KSHLNPP 1044
            GGGP+    GG R GG  PR QG G   G R     G RDG     G + G       P 
Sbjct: 222  GGGPR--PGGGPRPGG-GPRPQGQGRPGGQRDGQRDGQRDGQGNRGGQRQGAGAGGPRPQ 278

Query: 1045 HPKKA*HGSGSQG*SRESV----SDELGGGGIR 1131
               +   GS  QG S +      S E  GGG R
Sbjct: 279  GGPRPQGGSRPQGGSAQGAQGAPSQERQGGGRR 311

---

>P40602:APG_ARATH Anter-specific proline-rich protein APG precursor - Arabidopsis|
            thaliana (Mouse-ear cress)
          Length = 534

 Score = 34.7 bits (78), Expect = 1.5
 Identities = 19/51 (37%), Positives = 22/51 (43%)
 Frame = -3

Query: 1016 PH*PPIVPASPSLHPLPHTARCPSLKPEPCCRGSHPPTRSPPLCYHFGPPP 864
            P  PP     P+  P P  A  P+ KP PC     PP  +P      GPPP
Sbjct: 126  PPTPPKPQPKPAPPPEPKPAPPPAPKPVPCPSPPKPPAPTPKPVPPHGPPP 176



 Score = 32.0 bits (71), Expect = 9.7
 Identities = 20/53 (37%), Positives = 25/53 (47%), Gaps = 2/53 (3%)
 Frame = -3

Query: 1016 PH*PPIVPASPSLHPL--PHTARCPSLKPEPCCRGSHPPTRSPPLCYHFGPPP 864
            P   P+ P  PS  P+  P  + CPS  P+P  +   PP  SP  C    PPP
Sbjct: 65   PSPKPVAPPGPSSKPVAPPGPSPCPSPPPKP--QPKPPPAPSPSPCP--SPPP 113

---

>P20444:KPCA_MOUSE Protein kinase C alpha type - Mus musculus (Mouse)|
          Length = 672

 Score = 34.7 bits (78), Expect = 1.5
 Identities = 21/74 (28%), Positives = 36/74 (48%), Gaps = 1/74 (1%)
 Frame = +2

Query: 1502 DFYARVGIAGVVADTTMKETKVIKDNWIPTWDQEFEFPLAVPEL-ALLRVEVHESDNHQK 1678
            D Y ++ +     + + ++TK I+ N  P W++ F F L   +    L VE+ + D   +
Sbjct: 193  DPYVKLKLIPDPKNESKQKTKTIRSNLNPQWNESFTFKLKPSDKDRRLSVEIWDWDRTTR 252

Query: 1679 DDFAGQTCLPVWEL 1720
            +DF G     V EL
Sbjct: 253  NDFMGSLSFGVSEL 266

---

>O70557:SPR2F_MOUSE Small proline-rich protein 2F - Mus musculus (Mouse)|
          Length = 76

 Score = 34.3 bits (77), Expect = 2.0
 Identities = 20/48 (41%), Positives = 23/48 (47%), Gaps = 5/48 (10%)
 Frame = -3

Query: 995 PASPSLHPLP-HTARCPSLKPEPCCRGSH----PPTRSPPLCYHFGPP 867
           P SPS+ P P    +CP   PEPC   S     PP + PP C    PP
Sbjct: 26  PCSPSVCPEPCPPPKCPEPCPEPCPPPSFQQKCPPVQPPPPCQQKCPP 73

---

>Q8TAI1:CR056_HUMAN Putative uncharacterized protein C18orf56 - Homo sapiens (Human)|
          Length = 123

 Score = 34.3 bits (77), Expect = 2.0
 Identities = 24/73 (32%), Positives = 32/73 (43%), Gaps = 1/73 (1%)
 Frame = +3

Query: 741 GTCSTFRTLRQCPCSLPLRTSGARSSYRPNLPKSTLKPR-PARRRPKMVAQRRRACGGMR 917
           G C   RT+R  P  + +RT   R   RP  P+ + +PR P  R P     RR    G  
Sbjct: 49  GVCKARRTMRPLPGRIEVRTK--RGPQRPAAPERSPQPRLPPSRHPSRRGPRRH-LSGCS 105

Query: 918 SPTARLRFQRRTP 956
           +P  R+    R P
Sbjct: 106 APACRIPTGCRCP 118

---

>Q62746:SYT6_RAT Synaptotagmin-6 - Rattus norvegicus (Rat)|
          Length = 511

 Score = 34.3 bits (77), Expect = 2.0
 Identities = 23/77 (29%), Positives = 37/77 (48%), Gaps = 3/77 (3%)
 Frame = +2

Query: 1484 DKCSPPDFYARVGIAGVVADTTMK-ETKVIKDNWIPTWDQEFEFPLAVPELA--LLRVEV 1654
            D C   D Y ++ +   + D   K +T+V +    PT+D+ F FP+   ELA   L + V
Sbjct: 261  DFCGSSDPYVKIYL---LPDRKCKLQTRVHRKTLNPTFDENFHFPVPYEELADRKLHLSV 317

Query: 1655 HESDNHQKDDFAGQTCL 1705
             + D   + D  G+  L
Sbjct: 318  FDFDRFSRHDMIGEVIL 334

---

>Q9R0N8:SYT6_MOUSE Synaptotagmin-6 - Mus musculus (Mouse)|
          Length = 511

 Score = 34.3 bits (77), Expect = 2.0
 Identities = 23/77 (29%), Positives = 37/77 (48%), Gaps = 3/77 (3%)
 Frame = +2

Query: 1484 DKCSPPDFYARVGIAGVVADTTMK-ETKVIKDNWIPTWDQEFEFPLAVPELA--LLRVEV 1654
            D C   D Y ++ +   + D   K +T+V +    PT+D+ F FP+   ELA   L + V
Sbjct: 261  DFCGSSDPYVKIYL---LPDRKCKLQTRVHRKTLNPTFDENFHFPVPYEELADRKLHLSV 317

Query: 1655 HESDNHQKDDFAGQTCL 1705
             + D   + D  G+  L
Sbjct: 318  FDFDRFSRHDMIGEVIL 334

---

>Q5T7P8:SYT6_HUMAN Synaptotagmin-6 - Homo sapiens (Human)|
          Length = 510

 Score = 34.3 bits (77), Expect = 2.0
 Identities = 23/77 (29%), Positives = 37/77 (48%), Gaps = 3/77 (3%)
 Frame = +2

Query: 1484 DKCSPPDFYARVGIAGVVADTTMK-ETKVIKDNWIPTWDQEFEFPLAVPELA--LLRVEV 1654
            D C   D Y ++ +   + D   K +T+V +    PT+D+ F FP+   ELA   L + V
Sbjct: 260  DFCGSSDPYVKIYL---LPDRKCKLQTRVHRKTLNPTFDENFHFPVPYEELADRKLHLSV 316

Query: 1655 HESDNHQKDDFAGQTCL 1705
             + D   + D  G+  L
Sbjct: 317  FDFDRFSRHDMIGEVIL 333

---

>P63319:KPCG_RAT Protein kinase C gamma type - Rattus norvegicus (Rat)|
          Length = 697

 Score = 34.3 bits (77), Expect = 2.0
 Identities = 22/74 (29%), Positives = 36/74 (48%), Gaps = 1/74 (1%)
 Frame = +2

Query: 1502 DFYARVGIAGVVADTTMKETKVIKDNWIPTWDQEFEFPLAVPELAL-LRVEVHESDNHQK 1678
            D Y ++ +     + T ++TK +K    P W++ F F L   ++   L VEV + D   +
Sbjct: 193  DPYVKLKLIPDPRNLTKQKTKTVKATLNPVWNETFVFNLKPGDVERRLSVEVWDWDRTSR 252

Query: 1679 DDFAGQTCLPVWEL 1720
            +DF G     V EL
Sbjct: 253  NDFMGAMSFGVSEL 266

---

>P63318:KPCG_MOUSE Protein kinase C gamma type - Mus musculus (Mouse)|
          Length = 697

 Score = 34.3 bits (77), Expect = 2.0
 Identities = 22/74 (29%), Positives = 36/74 (48%), Gaps = 1/74 (1%)
 Frame = +2

Query: 1502 DFYARVGIAGVVADTTMKETKVIKDNWIPTWDQEFEFPLAVPELAL-LRVEVHESDNHQK 1678
            D Y ++ +     + T ++TK +K    P W++ F F L   ++   L VEV + D   +
Sbjct: 193  DPYVKLKLIPDPRNLTKQKTKTVKATLNPVWNETFVFNLKPGDVERRLSVEVWDWDRTSR 252

Query: 1679 DDFAGQTCLPVWEL 1720
            +DF G     V EL
Sbjct: 253  NDFMGAMSFGVSEL 266

---

>O70555:SPR2D_MOUSE Small proline-rich protein 2D - Mus musculus (Mouse)|
          Length = 85

 Score = 33.9 bits (76), Expect = 2.6
 Identities = 17/48 (35%), Positives = 20/48 (41%)
 Frame = -3

Query: 1007 PPIVPASPSLHPLPHTARCPSLKPEPCCRGSHPPTRSPPLCYHFGPPP 864
            PP+ P      P P   +CP   P P C    PP + P  C    PPP
Sbjct: 15   PPVCPPKKCPEPCP-PLKCPEPCPPPKCPEPCPPPKCPEPCPEPCPPP 61



 Score = 33.5 bits (75), Expect = 3.3
 Identities = 20/51 (39%), Positives = 23/51 (45%), Gaps = 4/51 (7%)
 Frame = -3

Query: 1007 PPIVPASPSLHPLPHTARCPSLKPEPC----CRGSHPPTRSPPLCYHFGPP 867
            PP  P  P   P P   +CP   PEPC    C+   PP + PP C    PP
Sbjct: 37   PP--PKCPEPCPPP---KCPEPCPEPCPPPSCQQKCPPAQPPPPCQQKCPP 82

---

>Q9ESD7:DYSF_MOUSE Dysferlin - Mus musculus (Mouse)|
          Length = 2083

 Score = 33.9 bits (76), Expect = 2.6
 Identities = 19/69 (27%), Positives = 38/69 (55%), Gaps = 3/69 (4%)
 Frame = +2

Query: 1523 IAGVVADTTMKETKVIKDNWIPTWDQEFEFPL---AVPELALLRVEVHESDNHQKDDFAG 1693
            +A ++     K TKVIK++  P W++ FE+ L    + + + L V V + +   ++ F G
Sbjct: 24   VASLIFRGVKKRTKVIKNSVNPVWNEGFEWDLKGIPLDQSSELLVVVKDHETMGRNRFLG 83

Query: 1694 QTCLPVWEL 1720
            +  +P+ E+
Sbjct: 84   EAKIPLQEV 92

---

>O14065:YC31_SCHPO Uncharacterized protein C962.01 - Schizosaccharomyces pombe (Fission|
            yeast)
          Length = 1429

 Score = 33.5 bits (75), Expect = 3.4
 Identities = 19/81 (23%), Positives = 43/81 (53%), Gaps = 3/81 (3%)
 Frame = +2

Query: 1556 ETKVIKDNWIPTWDQEFEFPLAVPELALLRVEVHESDNHQKDDFAGQTCLPVWELRSGI- 1732
            ++KVIK N  P W++E +  +    L +L +  ++ D  +K D  G + + +  L   + 
Sbjct: 1113 KSKVIKKNLNPVWNEEADIVVQNRVLDVLELVCYDWDMGEKPDVLGTSNIDLLSLEPNVE 1172

Query: 1733 --RSVRLYARDGEVLRSVKLL 1789
              +S++L ++ G +  S++ +
Sbjct: 1173 SQQSIKLDSKTGTINASLRFV 1193

---

>Q8IV90:WASF4_HUMAN Wiskott-Aldrich syndrome protein family member 4 - Homo sapiens|
            (Human)
          Length = 625

 Score = 33.1 bits (74), Expect = 4.4
 Identities = 25/68 (36%), Positives = 28/68 (41%), Gaps = 14/68 (20%)
 Frame = -3

Query: 1025 FYTPH*PPIVPASPSLHPLPHTARCPSLKPEPCC--------------RGSHPPTRSPPL 888
            F +P  PP  P+SPS  P P  A  P L P P                RG+ PP   PP 
Sbjct: 469  FGSPGTPP-PPSSPSFPPHPDFAAPPPLPPPPAADYPTLPPPPLSQPTRGAPPPPPPPPP 527

Query: 887  CYHFGPPP 864
                GPPP
Sbjct: 528  ----GPPP 531

---

>Q9UQ35:SRRM2_HUMAN Serine/arginine repetitive matrix protein 2 - Homo sapiens (Human)|
          Length = 2752

 Score = 33.1 bits (74), Expect = 4.4
 Identities = 39/118 (33%), Positives = 51/118 (43%), Gaps = 4/118 (3%)
 Frame = +3

Query: 798  TSGARSSYRPNLPKSTLKPRPARR--RPKMVAQRRRACGGMRSPTARLRFQRRTPSSMWK 971
            TS  RS  R    KS     P+RR  R +  A  +R     R+PT R   + R+P   W+
Sbjct: 458  TSKNRSHGRAKRDKSH-SHTPSRRMGRSRSPATAKRGRSRSRTPTKRGHSRSRSPQ--WR 514

Query: 972  RMKRWRCRDNWGSMRSIKVSSQSPSPEESMTWIRISRLIPR--KCLG*AWGRRHTRRP 1139
            R    R    WG  RS +   +S SP+    W R SR   R  +      GR H+R P
Sbjct: 515  RS---RSAQRWGRSRSPQRRGRSRSPQRP-GWSR-SRNTQRRGRSRSARRGRSHSRSP 567

---

>P97868:RBBP6_MOUSE Retinoblastoma-binding protein 6 - Mus musculus (Mouse)|
          Length = 1790

 Score = 33.1 bits (74), Expect = 4.4
 Identities = 17/44 (38%), Positives = 18/44 (40%)
 Frame = -3

Query: 998 VPASPSLHPLPHTARCPSLKPEPCCRGSHPPTRSPPLCYHFGPP 867
           VP  P   P PHT   P   P P      PP + PP  Y   PP
Sbjct: 560 VPPPPLYPPPPHTLPLPPGVPPPQFSPQFPPGQPPPAGYSVPPP 603

---

>Q7Z6E9:RBBP6_HUMAN Retinoblastoma-binding protein 6 - Homo sapiens (Human)|
          Length = 1792

 Score = 33.1 bits (74), Expect = 4.4
 Identities = 17/44 (38%), Positives = 18/44 (40%)
 Frame = -3

Query: 998 VPASPSLHPLPHTARCPSLKPEPCCRGSHPPTRSPPLCYHFGPP 867
           VP  P   P PHT   P   P P      PP + PP  Y   PP
Sbjct: 559 VPPPPLYPPPPHTLPLPPGVPPPQFSPQFPPGQPPPAGYSVPPP 602

---

>Q9M1G9:EXTN2_ARATH Extensin-2 precursor - Arabidopsis thaliana (Mouse-ear cress)|
          Length = 743

 Score = 33.1 bits (74), Expect = 4.4
 Identities = 21/65 (32%), Positives = 27/65 (41%), Gaps = 8/65 (12%)
 Frame = -3

Query: 1025 FYTPH*PPIVPASPSLH----PLPHTARCPSLKPEPCCRGSHPP----TRSPPLCYHFGP 870
            +Y    PP    SP ++    P PH   CP   P P C    P     +  PP  Y+  P
Sbjct: 642  YYKSPPPPYYSPSPKVYYKSPPHPHVCVCP---PPPPCYSPSPKVVYKSPPPPYVYNSPP 698

Query: 869  PPCWS 855
            PP +S
Sbjct: 699  PPYYS 703

---

>P50764:VE1_HPV29 Replication protein E1 - Human papillomavirus type 29|
          Length = 660

 Score = 33.1 bits (74), Expect = 4.4
 Identities = 36/146 (24%), Positives = 58/146 (39%), Gaps = 8/146 (5%)
 Frame = +2

Query: 500 KALRDGVRVIELDLWPNAAKDDVEVVHGRTWTSPVNLMKCLEAIKEHAFVSSPY--PVIL 673
           + + DG  V +  L   AA DD E VH                  +  F  SPY  PV +
Sbjct: 58  RPIGDGQEVAQELLLQQAAADDDEAVH----------------TVKRKFAPSPYFSPVCV 101

Query: 674 -TLEDHLTPHLQA-KVAKMIKETFGDLLHLSDS----EAMPVFPSPEDLRGKILISTKPP 835
            ++E  L+P L A K+ +   +    L  L DS      +     P  ++       +  
Sbjct: 102 PSIEHELSPRLDAIKLGRQSSKAKRRLFQLPDSGYGQTQVDTDTGPSQVQDGCETGDQNG 161

Query: 836 KEYLETKTSKEEAQNGSTEEESVWGD 913
           ++  +  +  ++ +NGS EEE   GD
Sbjct: 162 RQQYKEGSGTKDGENGSQEEERAGGD 187

---

>P10829:KPCG_RABIT Protein kinase C gamma type - Oryctolagus cuniculus (Rabbit)|
          Length = 697

 Score = 33.1 bits (74), Expect = 4.4
 Identities = 21/74 (28%), Positives = 36/74 (48%), Gaps = 1/74 (1%)
 Frame = +2

Query: 1502 DFYARVGIAGVVADTTMKETKVIKDNWIPTWDQEFEFPLAVPELAL-LRVEVHESDNHQK 1678
            D Y ++ +     + T ++T+ +K    P W++ F F L   ++   L VEV + D   +
Sbjct: 193  DPYVKLKLIPDPRNLTKQKTRTVKATLNPVWNETFVFNLKPGDVERRLSVEVWDWDRTSR 252

Query: 1679 DDFAGQTCLPVWEL 1720
            +DF G     V EL
Sbjct: 253  NDFMGAMSFGVSEL 266

---

>Q4R4U2:KPCG_MACFA Protein kinase C gamma type - Macaca fascicularis (Crab eating|
            macaque) (Cynomolgus monkey)
          Length = 697

 Score = 33.1 bits (74), Expect = 4.4
 Identities = 21/74 (28%), Positives = 36/74 (48%), Gaps = 1/74 (1%)
 Frame = +2

Query: 1502 DFYARVGIAGVVADTTMKETKVIKDNWIPTWDQEFEFPLAVPELAL-LRVEVHESDNHQK 1678
            D Y ++ +     + T ++T+ +K    P W++ F F L   ++   L VEV + D   +
Sbjct: 193  DPYVKLKLIPDPRNLTKQKTRTVKATLNPVWNETFVFNLKPGDVERRLSVEVWDWDRTSR 252

Query: 1679 DDFAGQTCLPVWEL 1720
            +DF G     V EL
Sbjct: 253  NDFMGAMSFGVSEL 266

---

>P05129:KPCG_HUMAN Protein kinase C gamma type - Homo sapiens (Human)|
          Length = 697

 Score = 33.1 bits (74), Expect = 4.4
 Identities = 21/74 (28%), Positives = 36/74 (48%), Gaps = 1/74 (1%)
 Frame = +2

Query: 1502 DFYARVGIAGVVADTTMKETKVIKDNWIPTWDQEFEFPLAVPELAL-LRVEVHESDNHQK 1678
            D Y ++ +     + T ++T+ +K    P W++ F F L   ++   L VEV + D   +
Sbjct: 193  DPYVKLKLIPDPRNLTKQKTRTVKATLNPVWNETFVFNLKPGDVERRLSVEVWDWDRTSR 252

Query: 1679 DDFAGQTCLPVWEL 1720
            +DF G     V EL
Sbjct: 253  NDFMGAMSFGVSEL 266

---

>P05128:KPCG_BOVIN Protein kinase C gamma type - Bos taurus (Bovine)|
          Length = 682

 Score = 33.1 bits (74), Expect = 4.4
 Identities = 21/74 (28%), Positives = 36/74 (48%), Gaps = 1/74 (1%)
 Frame = +2

Query: 1502 DFYARVGIAGVVADTTMKETKVIKDNWIPTWDQEFEFPLAVPELAL-LRVEVHESDNHQK 1678
            D Y ++ +     + T ++T+ +K    P W++ F F L   ++   L VEV + D   +
Sbjct: 178  DPYVKLKLIPDPRNLTKQKTRTVKATLNPVWNETFVFNLKPGDVERRLSVEVWDWDRTSR 237

Query: 1679 DDFAGQTCLPVWEL 1720
            +DF G     V EL
Sbjct: 238  NDFMGAMSFGVSEL 251

---

>O75923:DYSF_HUMAN Dysferlin - Homo sapiens (Human)|
          Length = 2080

 Score = 33.1 bits (74), Expect = 4.4
 Identities = 23/76 (30%), Positives = 39/76 (51%), Gaps = 3/76 (3%)
 Frame = +2

Query: 1502 DFYARVGIAGVVADTTMKETKVIKDNWIPTWDQEFEFPL---AVPELALLRVEVHESDNH 1672
            D Y     AGV      K TKVIK++  P W++ FE+ L    + + + L V V + +  
Sbjct: 21   DAYCSAVFAGV-----KKRTKVIKNSVNPVWNEGFEWDLKGIPLDQGSELHVVVKDHETM 75

Query: 1673 QKDDFAGQTCLPVWEL 1720
             ++ F G+  +P+ E+
Sbjct: 76   GRNRFLGEAKVPLREV 91



 Score = 32.0 bits (71), Expect = 9.8
 Identities = 28/94 (29%), Positives = 43/94 (45%), Gaps = 13/94 (13%)
 Frame = +2

Query: 1553 KETKVIKDNWIPTWDQEFEF--------PLAVPEL-ALLRVEVHESDNHQKDDFAGQ-TC 1702
            ++T V+K+   PTWDQ   F        P  V E    + VE+++ D +  D+F G+  C
Sbjct: 1186 QKTVVVKNTLNPTWDQTLIFYEIEIFGEPATVAEQPPSIVVELYDHDTYGADEFMGRCIC 1245

Query: 1703 LPVWELRSGIR---SVRLYARDGEVLRSVKLLMR 1795
             P  E    +      R     GE+L S +L+ R
Sbjct: 1246 QPSLERMPRLAWFPLTRGSQPSGELLASFELIQR 1279

---

>O70554:SPR2B_MOUSE Small proline-rich protein 2B - Mus musculus (Mouse)|
          Length = 98

 Score = 32.7 bits (73), Expect = 5.7
 Identities = 18/53 (33%), Positives = 22/53 (41%), Gaps = 5/53 (9%)
 Frame = -3

Query: 1007 PPIVPASPSLHPLPHTARCPSLKPEPCCRGSHPPTR-----SPPLCYHFGPPP 864
            PP+ P      P P   +CP   P P C    PP +      PP+C    PPP
Sbjct: 15   PPVCPPPKCPEPCP-PPKCPEPCPPPVCCEPCPPPKCPEPCPPPVCCEPCPPP 66

---

>Q6PB44:PTN23_MOUSE Tyrosine-protein phosphatase non-receptor type 23 - Mus musculus|
            (Mouse)
          Length = 1692

 Score = 32.7 bits (73), Expect = 5.7
 Identities = 18/45 (40%), Positives = 20/45 (44%)
 Frame = -3

Query: 1007 PPIVPASPSLHPLPHTARCPSLKPEPCCRGSHPPTRSPPLCYHFG 873
            PP    +PS H +P  A  P   P P    S PPT  PP C   G
Sbjct: 1129 PPASQPTPSPHLVPSPAPSPGPGPVP----SRPPTAEPPPCLRRG 1169

---

>Q5T871:LELP1_HUMAN Late cornified envelope-like proline-rich protein 1 - Homo sapiens|
           (Human)
          Length = 98

 Score = 32.7 bits (73), Expect = 5.7
 Identities = 18/47 (38%), Positives = 22/47 (46%), Gaps = 2/47 (4%)
 Frame = -3

Query: 995 PASPSLHPLPHTA--RCPSLKPEPCCRGSHPPTRSPPLCYHFGPPPC 861
           PA P   P P  +   CP   P+PC +    P + P  C H  PPPC
Sbjct: 53  PAPPKCLPCPSQSPSSCP---PQPCTKPC--PPKCPSSCPHACPPPC 94

---

>P48733:UROM_BOVIN Uromodulin precursor - Bos taurus (Bovine)|
          Length = 643

 Score = 32.7 bits (73), Expect = 5.7
 Identities = 38/153 (24%), Positives = 56/153 (36%), Gaps = 8/153 (5%)
 Frame = -1

Query: 1543 VCNNSCYTHPCIEVWWRALIEMRLTEVESPSVSHVDSNLEPCLHW*FRSRVKHFIRLHKK 1364
            VC + C  H  ++ +WR+      TE  S  +  V       L   +R   +  +RL + 
Sbjct: 171  VCVDPCQVHRILDEYWRS------TEYGSGYICDVS------LGGWYRFVGQAGVRLPET 218

Query: 1363 -IRLFHITTTA---ICSEHPLSQP*FPSMTLHVCCNHLSSICPSHQWIVIG*SNARCLWE 1196
             + + H  T A   +   HP S      +   V C H S  C              CLW+
Sbjct: 219  CVPVLHCNTAAPMWLNGTHPSSD---EGIVNRVACAHWSGDC--------------CLWD 261

Query: 1195 NP*QVPLCK----LYNFRSMCNCGLLVCRLPQA 1109
             P QV  C     +YN  +   C L  C  P +
Sbjct: 262  APIQVKACAGGYYVYNLTAPPECHLAYCTDPSS 294

---

>Q62768:UN13A_RAT Unc-13 homolog A - Rattus norvegicus (Rat)|
          Length = 1735

 Score = 32.7 bits (73), Expect = 5.7
 Identities = 24/86 (27%), Positives = 33/86 (38%), Gaps = 10/86 (11%)
 Frame = +2

Query: 1484 DKCSPPDFYARVGIAGVVADTTMKETKVIKDNWIPTWDQEFEFPL----------AVPEL 1633
            DK    D Y  V +       T K TK I  N  P W++ F F             + E 
Sbjct: 705  DKTGSSDPYVTVQVG-----KTKKRTKTIYGNLNPVWEENFHFECHNSSDRIKVRVLDED 759

Query: 1634 ALLRVEVHESDNHQKDDFAGQTCLPV 1711
              ++  V +    + DDF GQT + V
Sbjct: 760  DDIKSRVKQRFKRESDDFLGQTIIEV 785

---

>P49147:PA24A_CHICK Cytosolic phospholipase A2 - Gallus gallus (Chicken)|
          Length = 748

 Score = 32.7 bits (73), Expect = 5.7
 Identities = 23/82 (28%), Positives = 37/82 (45%)
 Frame = +2

Query: 1484 DKCSPPDFYARVGIAGVVADTTMKETKVIKDNWIPTWDQEFEFPLAVPELALLRVEVHES 1663
            D    PD Y  + I    A    K TK   ++  P W++ FEF L   +  +L V + ++
Sbjct: 37   DMLDTPDPYVELFIPS--APDCRKRTKHFNNDVNPVWNETFEFILDPNQDNVLEVTLMDA 94

Query: 1664 DNHQKDDFAGQTCLPVWELRSG 1729
             N+  D+  G    P+  L+ G
Sbjct: 95   -NYVMDETLGMATFPISSLKLG 115

---

>Q9UMN6:WBP7_HUMAN WW domain-binding protein 7 - Homo sapiens (Human)|
          Length = 2715

 Score = 32.3 bits (72), Expect = 7.5
 Identities = 20/49 (40%), Positives = 23/49 (46%), Gaps = 1/49 (2%)
 Frame = -3

Query: 1007 PPIVPASPSLHP-LPHTARCPSLKPEPCCRGSHPPTRSPPLCYHFGPPP 864
            PP+ P +PS  P LP  +  P   P P C    PP   PPL     PPP
Sbjct: 404  PPLTPPAPSPPPPLPPPSTSP---PPPLCPPPPPPVSPPPLP---SPPP 446

---

>Q1DS65:STU1_COCIM Protein STU1 - Coccidioides immitis|
          Length = 1156

 Score = 32.3 bits (72), Expect = 7.5
 Identities = 41/132 (31%), Positives = 57/132 (43%), Gaps = 8/132 (6%)
 Frame = +3

Query: 783  SLPLRTSGARSSYRPNLPKSTLKPRPARRRPKMVAQRRRACGGMRSPTARLRFQRRTPSS 962
            ++P R   A+SS+    PKS    RPA RRP   +  R   G   S +A L      P+S
Sbjct: 610  NVPSRPESAQSSFPD--PKSG---RPAPRRPTGTSTIRVPTGEKLSQSASLSSAPMRPAS 664

Query: 963  MWKR--MKRWRCRDNWGSMRSI------KVSSQSPSPEESMTWIRISRLIPRKCLG*AWG 1118
              +R  + R    D + S RS       K SS S SP++S + +  +   PR        
Sbjct: 665  RPRRPELVRPATADPYSSRRSAAPTAQSKASSPSDSPQKSKSKLMTT---PR-------S 714

Query: 1119 RRHTRRPQLHMD 1154
            R    RP+  MD
Sbjct: 715  RNPLARPKSRMD 726

---

>Q5ZMJ9:SRRM1_CHICK Serine/arginine repetitive matrix protein 1 - Gallus gallus (Chicken)|
          Length = 888

 Score = 32.3 bits (72), Expect = 7.5
 Identities = 31/106 (29%), Positives = 41/106 (38%)
 Frame = +3

Query: 732  RHSGTCSTFRTLRQCPCSLPLRTSGARSSYRPNLPKSTLKPRPARRRPKMVAQRRRACGG 911
            R   + S  R     P + P+R    R S  P  PK T    P+ R  + V+  R A G 
Sbjct: 694  RRGASASPQRRQSPSPSTRPIR----RVSRTPE-PKKTKASTPSPRSARRVSSSRSASG- 747

Query: 912  MRSPTARLRFQRRTPSSMWKRMKRWRCRDNWGSMRSIKVSSQSPSP 1049
              SP    +  +  PS    R        NW   +  K  +QSPSP
Sbjct: 748  --SPEPAPKKHQGPPSPARSRSPS----ANWSPAKKAKSPTQSPSP 787

---

>O88902:PTN23_RAT Tyrosine-protein phosphatase non-receptor type 23 - Rattus norvegicus|
            (Rat)
          Length = 1499

 Score = 32.3 bits (72), Expect = 7.5
 Identities = 18/45 (40%), Positives = 20/45 (44%)
 Frame = -3

Query: 1007 PPIVPASPSLHPLPHTARCPSLKPEPCCRGSHPPTRSPPLCYHFG 873
            PP    +PS H +P  A  P   P P    S PPT  PP C   G
Sbjct: 936  PPANQPAPSPHLVPSPAPSPGPGPVP----SRPPTAEPPPCLRRG 976

---

>P40603:APG_BRANA Anther-specific proline-rich protein APG - Brassica napus (Rape)|
          Length = 449

 Score = 32.3 bits (72), Expect = 7.5
 Identities = 18/43 (41%), Positives = 20/43 (46%)
 Frame = -3

Query: 1019 TPH*PPIVPASPSLHPLPHTARCPSLKPEPCCRGSHPPTRSPP 891
            +P   P+ P SPS  P P     PS KP P      PP  SPP
Sbjct: 78   SPAPKPVPPPSPSPKPSPPKPPAPSPKPSP----PKPPAPSPP 116

---

>O14795:UN13B_HUMAN Unc-13 homolog B - Homo sapiens (Human)|
          Length = 1591

 Score = 32.3 bits (72), Expect = 7.5
 Identities = 25/87 (28%), Positives = 36/87 (41%), Gaps = 11/87 (12%)
 Frame = +2

Query: 1484 DKCSPPDFYARVGIAGVVADTTMKETKVIKDNWIPTWDQEFEFPLAVPELALLRVEVHES 1663
            DK    D Y  V ++      T K TK I  N  P W+++F F         ++V V + 
Sbjct: 616  DKTGSSDPYVTVQVS-----KTKKRTKTIFGNLNPVWEEKFHFE-CHNSSDRIKVRVWDE 669

Query: 1664 DN-----------HQKDDFAGQTCLPV 1711
            D+            + DDF GQT + V
Sbjct: 670  DDDIKSRVKQRLKRESDDFLGQTIIEV 696

---

>P05696:KPCA_RAT Protein kinase C alpha type - Rattus norvegicus (Rat)|
          Length = 672

 Score = 32.3 bits (72), Expect = 7.5
 Identities = 20/74 (27%), Positives = 35/74 (47%), Gaps = 1/74 (1%)
 Frame = +2

Query: 1502 DFYARVGIAGVVADTTMKETKVIKDNWIPTWDQEFEFPLAVPEL-ALLRVEVHESDNHQK 1678
            D Y ++ +     + + ++TK I+    P W++ F F L   +    L VE+ + D   +
Sbjct: 193  DPYVKLKLIPDPKNESKQKTKTIRSTLNPQWNESFTFKLKPSDKDRRLSVEIWDWDRTTR 252

Query: 1679 DDFAGQTCLPVWEL 1720
            +DF G     V EL
Sbjct: 253  NDFMGSLSFGVSEL 266

---

>P10102:KPCA_RABIT Protein kinase C alpha type - Oryctolagus cuniculus (Rabbit)|
          Length = 672

 Score = 32.3 bits (72), Expect = 7.5
 Identities = 20/74 (27%), Positives = 35/74 (47%), Gaps = 1/74 (1%)
 Frame = +2

Query: 1502 DFYARVGIAGVVADTTMKETKVIKDNWIPTWDQEFEFPLAVPEL-ALLRVEVHESDNHQK 1678
            D Y ++ +     + + ++TK I+    P W++ F F L   +    L VE+ + D   +
Sbjct: 193  DPYVKLKLIPDPKNESKQKTKTIRSTLNPQWNESFTFKLKPSDKDRRLSVEIWDWDRTTR 252

Query: 1679 DDFAGQTCLPVWEL 1720
            +DF G     V EL
Sbjct: 253  NDFMGSLSFGVSEL 266

---

>P17252:KPCA_HUMAN Protein kinase C alpha type - Homo sapiens (Human)|
          Length = 672

 Score = 32.3 bits (72), Expect = 7.5
 Identities = 20/74 (27%), Positives = 35/74 (47%), Gaps = 1/74 (1%)
 Frame = +2

Query: 1502 DFYARVGIAGVVADTTMKETKVIKDNWIPTWDQEFEFPLAVPEL-ALLRVEVHESDNHQK 1678
            D Y ++ +     + + ++TK I+    P W++ F F L   +    L VE+ + D   +
Sbjct: 193  DPYVKLKLIPDPKNESKQKTKTIRSTLNPQWNESFTFKLKPSDKDRRLSVEIWDWDRTTR 252

Query: 1679 DDFAGQTCLPVWEL 1720
            +DF G     V EL
Sbjct: 253  NDFMGSLSFGVSEL 266

---

>O70559:SPR2H_MOUSE Small proline-rich protein 2H - Mus musculus (Mouse)|
          Length = 108

 Score = 32.0 bits (71), Expect = 9.7
 Identities = 17/48 (35%), Positives = 20/48 (41%)
 Frame = -3

Query: 1007 PPIVPASPSLHPLPHTARCPSLKPEPCCRGSHPPTRSPPLCYHFGPPP 864
            PP+ P      P P   +CP   P P C    PP + P  C    PPP
Sbjct: 15   PPVCPPPQCPEPCP-PPKCPEPCPPPKCTEPCPPPKCPEPC----PPP 57

---

>Q38913:EXTN1_ARATH Extensin-1 precursor - Arabidopsis thaliana (Mouse-ear cress)|
          Length = 373

 Score = 32.0 bits (71), Expect = 9.7
 Identities = 21/57 (36%), Positives = 29/57 (50%), Gaps = 3/57 (5%)
 Frame = -3

Query: 1025 FYTPH*PPIVPASPSLHPLPHTARCPSLK--PEPCCRGSHPPT-RSPPLCYHFGPPP 864
            +Y+P  PP+  + P   P+ H +  P  K  P P    S PP  +SPP   H+ PPP
Sbjct: 200  YYSP--PPVYKSPPP--PVKHYSPPPVYKSPPPPVKYYSPPPVYKSPPPPVHYSPPP 252

---

>Q62769:UN13B_RAT Unc-13 homolog B - Rattus norvegicus (Rat)|
          Length = 1622

 Score = 32.0 bits (71), Expect = 9.8
 Identities = 25/87 (28%), Positives = 35/87 (40%), Gaps = 11/87 (12%)
 Frame = +2

Query: 1484 DKCSPPDFYARVGIAGVVADTTMKETKVIKDNWIPTWDQEFEFPLAVPELALLRVEVHES 1663
            DK    D Y  V +       T K TK I  N  P W+++F F         ++V V + 
Sbjct: 629  DKTGSSDPYVTVQVG-----KTKKRTKTIFGNLNPVWEEKFHFE-CHNSSDRIKVRVWDE 682

Query: 1664 DN-----------HQKDDFAGQTCLPV 1711
            D+            + DDF GQT + V
Sbjct: 683  DDDIKSRVKQRLKRESDDFLGQTIIEV 709

---

>Q9Z1N9:UN13B_MOUSE Unc-13 homolog B - Mus musculus (Mouse)|
          Length = 1591

 Score = 32.0 bits (71), Expect = 9.8
 Identities = 25/87 (28%), Positives = 35/87 (40%), Gaps = 11/87 (12%)
 Frame = +2

Query: 1484 DKCSPPDFYARVGIAGVVADTTMKETKVIKDNWIPTWDQEFEFPLAVPELALLRVEVHES 1663
            DK    D Y  V +       T K TK I  N  P W+++F F         ++V V + 
Sbjct: 616  DKTGSSDPYVTVQVG-----KTKKRTKTIFGNLNPVWEEKFHFE-CHNSSDRIKVRVWDE 669

Query: 1664 DN-----------HQKDDFAGQTCLPV 1711
            D+            + DDF GQT + V
Sbjct: 670  DDDIKSRVKQRLKRESDDFLGQTIIEV 696

---

>Q9UPW8:UN13A_HUMAN Unc-13 homolog A - Homo sapiens (Human)|
          Length = 1703

 Score = 32.0 bits (71), Expect = 9.8
 Identities = 25/87 (28%), Positives = 34/87 (39%), Gaps = 11/87 (12%)
 Frame = +2

Query: 1484 DKCSPPDFYARVGIAGVVADTTMKETKVIKDNWIPTWDQEFEFPLAVPELALLRVEVHES 1663
            DK    D Y  V +       T K TK I  N  P W++ F F         ++V V + 
Sbjct: 692  DKTGSSDPYVTVQVG-----KTKKRTKTIYGNLNPVWEENFHFE-CHNSSDRIKVRVWDE 745

Query: 1664 DN-----------HQKDDFAGQTCLPV 1711
            D+            + DDF GQT + V
Sbjct: 746  DDDIKSRVKQRFKRESDDFLGQTIIEV 772

---

>Q9Z268:RASL1_MOUSE RasGAP-activating-like protein 1 - Mus musculus (Mouse)|
          Length = 799

 Score = 32.0 bits (71), Expect = 9.8
 Identities = 18/46 (39%), Positives = 23/46 (50%)
 Frame = +2

Query: 1556 ETKVIKDNWIPTWDQEFEFPLAVPELALLRVEVHESDNHQKDDFAG 1693
            ET  IK    P WD+  E   A    + LRVE+ + D   K+DF G
Sbjct: 168  ETSTIKKTRFPHWDEVLELREAPGTTSPLRVELWDWDMVGKNDFLG 213

---

>Q9V427:INX2_DROME Innexin inx2 - Drosophila melanogaster (Fruit fly)|
          Length = 367

 Score = 32.0 bits (71), Expect = 9.8
 Identities = 14/38 (36%), Positives = 22/38 (57%), Gaps = 7/38 (18%)
 Frame = +2

Query: 1145 THGSEIIKFTQRN-------LLRIFPKTTRITSSNYNP 1237
            T+GS+++KFT+         + R+FPK T+ T   Y P
Sbjct: 208  TYGSDVLKFTELEPDERIDPMARVFPKVTKCTFHKYGP 245


  Database: uniprot_sprot.fasta.out
    Posted date:  Jul 19, 2007  5:58 PM
  Number of letters in database: 100,686,439
  Number of sequences in database:  274,295
  
Lambda     K      H
   0.318    0.134    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 274295
Number of Hits to DB: 323,847,912
Number of extensions: 7353114
Number of successful extensions: 24166
Number of sequences better than 10.0: 97
Number of HSP's gapped: 23790
Number of HSP's successfully gapped: 135
Length of query: 660
Length of database: 100,686,439
Length adjustment: 120
Effective length of query: 540
Effective length of database: 67,771,039
Effective search space: 36596361060
Effective search space used: 36596361060
Neighboring words threshold: 12
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)

---