ナショナルバイオリソースプロジェクト
-Barley Genetic Resources Database-
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| Clone Name | FLbaf62n06 |
|---|---|
| Clone Library Name | barley_pub |
>Q5QN75:M2K1_ORYSJ Mitogen-activated protein kinase kinase 1 - Oryza sativa subsp.| japonica (Rice) Length = 355 Score = 665 bits (1717), Expect = 0.0 Identities = 332/355 (93%), Positives = 340/355 (95%) Frame = +1 Query: 94 MRGKKPLKELTLSVPAQETPVDKFLTASGTFKDGELRLNQRGLQLISEENGDEHQSTKMK 273 MRGKKP KEL LSVPAQETPVDKFLTASGTFKDGELRLNQRGLQLISEE DE QST +K Sbjct: 1 MRGKKPHKELKLSVPAQETPVDKFLTASGTFKDGELRLNQRGLQLISEETADEPQSTNLK 60 Query: 274 VEDVQLSMDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQIVQELKI 453 VEDVQLSMDDLEMIQVIGKGSGG+VQLVRHKWVGT YALKGIQMNIQE+VRKQIVQELKI Sbjct: 61 VEDVQLSMDDLEMIQVIGKGSGGIVQLVRHKWVGTLYALKGIQMNIQEAVRKQIVQELKI 120 Query: 454 NQATQSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGL 633 NQATQ+ HIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGL Sbjct: 121 NQATQNAHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGL 180 Query: 634 LYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERI 813 LYLHHERHVIHRDIKPSNLLVN KGEVKITDFGVSAVLASS+GQRDTFVGTYNYMAPERI Sbjct: 181 LYLHHERHVIHRDIKPSNLLVNRKGEVKITDFGVSAVLASSMGQRDTFVGTYNYMAPERI 240 Query: 814 SGSSYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAPADQFS 993 SGSSYDYKSD+WSLGLVILECAIGRFPY P EGEGWLSFYELLEAIVDQPPPSAPADQFS Sbjct: 241 SGSSYDYKSDIWSLGLVILECAIGRFPYIPSEGEGWLSFYELLEAIVDQPPPSAPADQFS 300 Query: 994 PEFCSFISSCIQKDPAERKSASELLNHAFIKKFEDKDLDLRILVESLEQPMNVPE 1158 PEFC+FISSCIQKDPAER SASELLNH FIKKFEDKDLDLRILVESLE PMN+ E Sbjct: 301 PEFCAFISSCIQKDPAERMSASELLNHPFIKKFEDKDLDLRILVESLEPPMNISE 355
>Q9FJV0:M2K6_ARATH Mitogen-activated protein kinase kinase 6 - Arabidopsis thaliana| (Mouse-ear cress) Length = 356 Score = 509 bits (1312), Expect = e-144 Identities = 252/351 (71%), Positives = 299/351 (85%), Gaps = 2/351 (0%) Frame = +1 Query: 103 KKPLKELTLSVPAQETPVDKFLTASGTFKDGELRLNQRGLQLISEENGDEHQSTKMKVED 282 K LK+L LSVPAQE+P+ FLTASGTF DG+ LNQ+GL+L S+E + + + K D Sbjct: 5 KSNLKQLKLSVPAQESPISSFLTASGTFHDGDFLLNQKGLRLTSDEK--QSRQSDSKELD 62 Query: 283 VQLSMDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQIVQELKINQA 462 +++ +DLE ++VIGKGSGGVVQLVRHKWVG F+A+K IQMNIQE +RKQIVQELKINQA Sbjct: 63 FEITAEDLETVKVIGKGSGGVVQLVRHKWVGKFFAMKVIQMNIQEEIRKQIVQELKINQA 122 Query: 463 T-QSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLY 639 + Q PH+V+C+ SFYHNG LVLEYMDRGSLAD+I+QVKTILEPYLAV+CKQVL GL+Y Sbjct: 123 SSQCPHVVVCYHSFYHNGAFSLVLEYMDRGSLADVIRQVKTILEPYLAVVCKQVLLGLVY 182 Query: 640 LHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISG 819 LH+ERHVIHRDIKPSNLLVNHKGEVKI+DFGVSA LASS+GQRDTFVGTYNYM+PERISG Sbjct: 183 LHNERHVIHRDIKPSNLLVNHKGEVKISDFGVSASLASSMGQRDTFVGTYNYMSPERISG 242 Query: 820 SSYDYKSDVWSLGLVILECAIGRFPYTPPEG-EGWLSFYELLEAIVDQPPPSAPADQFSP 996 S+YDY SD+WSLG+ +LECAIGRFPY E + SFYELL AIV+ PPP+AP+DQFSP Sbjct: 243 STYDYSSDIWSLGMSVLECAIGRFPYLESEDQQNPPSFYELLAAIVENPPPTAPSDQFSP 302 Query: 997 EFCSFISSCIQKDPAERKSASELLNHAFIKKFEDKDLDLRILVESLEQPMN 1149 EFCSF+S+CIQKDP R S+ +LL+H FIKKFEDKD+DL ILV +LE P+N Sbjct: 303 EFCSFVSACIQKDPPARASSLDLLSHPFIKKFEDKDIDLGILVGTLEPPVN 353
>Q9S7U9:M2K2_ARATH Mitogen-activated protein kinase kinase 2 - Arabidopsis thaliana| (Mouse-ear cress) Length = 363 Score = 414 bits (1064), Expect = e-115 Identities = 199/333 (59%), Positives = 261/333 (78%), Gaps = 2/333 (0%) Frame = +1 Query: 121 LTLSVP-AQETPVDKFLTASGTFKDGELRLNQRGLQLISEENGDEHQSTKMKVEDVQLSM 297 L L++P A E + KFLT SGTFKDG+LR+N+ G+++IS+ + + +K D QLS+ Sbjct: 10 LKLAIPVAGEQSITKFLTQSGTFKDGDLRVNKDGVRIISQL--EPEVLSPIKPADDQLSL 67 Query: 298 DDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQIVQELKINQATQSPH 477 DL+M++VIGKGS GVVQLV+HKW G F+ALK IQ+NI E++RK I QELKINQ++Q P+ Sbjct: 68 SDLDMVKVIGKGSSGVVQLVQHKWTGQFFALKVIQLNIDEAIRKAIAQELKINQSSQCPN 127 Query: 478 IVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLYLHHERH 657 +V +QSFY NG I L+LEYMD GSLAD +K VK I + YL+ + +QVL+GL+YLHH+RH Sbjct: 128 LVTSYQSFYDNGAISLILEYMDGGSLADFLKSVKAIPDSYLSAIFRQVLQGLIYLHHDRH 187 Query: 658 VIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISGSSYDYK 837 +IHRD+KPSNLL+NH+GEVKITDFGVS V+ ++ G +TFVGTYNYM+PERI G+ Y K Sbjct: 188 IIHRDLKPSNLLINHRGEVKITDFGVSTVMTNTAGLANTFVGTYNYMSPERIVGNKYGNK 247 Query: 838 SDVWSLGLVILECAIGRFPYTPP-EGEGWLSFYELLEAIVDQPPPSAPADQFSPEFCSFI 1014 SD+WSLGLV+LECA G+FPY PP + E W S +EL+EAIVDQPPP+ P+ FSPE SFI Sbjct: 248 SDIWSLGLVVLECATGKFPYAPPNQEETWTSVFELMEAIVDQPPPALPSGNFSPELSSFI 307 Query: 1015 SSCIQKDPAERKSASELLNHAFIKKFEDKDLDL 1113 S+C+QKDP R SA EL+ H F+ K++ ++L Sbjct: 308 STCLQKDPNSRSSAKELMEHPFLNKYDYSGINL 340
>Q94A06:M2K1_ARATH Mitogen-activated protein kinase kinase 1 - Arabidopsis thaliana| (Mouse-ear cress) Length = 354 Score = 404 bits (1039), Expect = e-112 Identities = 195/330 (59%), Positives = 255/330 (77%), Gaps = 1/330 (0%) Frame = +1 Query: 127 LSVPAQETPVDKFLTASGTFKDGELRLNQRGLQLISEENGDEHQSTKMKVEDVQLSMDDL 306 + +P E + KFLT SGTFKDG+LR+N+ G+Q +S + ++ D QLS+ DL Sbjct: 11 ICLPPLEQSISKFLTQSGTFKDGDLRVNKDGIQTVSLS--EPGAPPPIEPLDNQLSLADL 68 Query: 307 EMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQIVQELKINQATQSPHIVL 486 E+I+VIGKGS G VQLV+HK F+ALK IQ+N +ES + I QEL+IN ++Q P++V Sbjct: 69 EVIKVIGKGSSGNVQLVKHKLTQQFFALKVIQLNTEESTCRAISQELRINLSSQCPYLVS 128 Query: 487 CHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLYLHHERHVIH 666 C+QSFYHNG++ ++LE+MD GSLAD++K+V + E L+ +CK+VL GL Y+HHER +IH Sbjct: 129 CYQSFYHNGLVSIILEFMDGGSLADLLKKVGKVPENMLSAICKRVLRGLCYIHHERRIIH 188 Query: 667 RDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISGSSYDYKSDV 846 RD+KPSNLL+NH+GEVKITDFGVS +L S+ ++FVGTY YM+PERISGS Y KSD+ Sbjct: 189 RDLKPSNLLINHRGEVKITDFGVSKILTSTSSLANSFVGTYPYMSPERISGSLYSNKSDI 248 Query: 847 WSLGLVILECAIGRFPYTPPE-GEGWLSFYELLEAIVDQPPPSAPADQFSPEFCSFISSC 1023 WSLGLV+LECA G+FPYTPPE +GW S YEL++AIV+ PPP AP++ FSPEFCSFIS C Sbjct: 249 WSLGLVLLECATGKFPYTPPEHKKGWSSVYELVDAIVENPPPCAPSNLFSPEFCSFISQC 308 Query: 1024 IQKDPAERKSASELLNHAFIKKFEDKDLDL 1113 +QKDP +RKSA ELL H F+K FED D +L Sbjct: 309 VQKDPRDRKSAKELLEHKFVKMFEDSDTNL 338
>Q90891:MP2K2_CHICK Dual specificity mitogen-activated protein kinase kinase 2 - Gallus| gallus (Chicken) Length = 398 Score = 234 bits (598), Expect = 5e-61 Identities = 141/378 (37%), Positives = 208/378 (55%), Gaps = 52/378 (13%) Frame = +1 Query: 133 VPAQETPVDKFLT-----ASGTFKDGELRLNQRGLQLISEE-NGDEHQSTKM------KV 276 +PA+ PV LT A G G N LQ EE DE Q ++ K Sbjct: 1 MPAKRKPVLPALTITPSPAEGPGPGGSAEANLVDLQKKLEELELDEQQKKRLEAFLTQKA 60 Query: 277 EDVQLSMDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQIVQELKIN 456 + +L DD E I +G G+GGVV V+HK G A K I + I+ ++R QI++EL++ Sbjct: 61 KVGELKDDDFERISELGAGNGGVVTKVQHKPSGLIMARKLIHLEIKPAIRNQIIRELQVL 120 Query: 457 QATQSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLL 636 SP+IV + +FY +G I + +E+MD GSL ++K+ K I E L + VL GL Sbjct: 121 HECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRGLA 180 Query: 637 YLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERIS 816 YL + ++HRD+KPSN+LVN +GE+K+ DFGVS L S+ ++FVGT +YM+PER+ Sbjct: 181 YLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA--NSFVGTRSYMSPERLQ 238 Query: 817 GSSYDYKSDVWSLGLVILECAIGRFPYTPP-----------------EGEG-----W--- 921 G+ Y +SD+WS+GL ++E +IGR+P PP EGE W Sbjct: 239 GTHYSVQSDIWSMGLSLVELSIGRYPIPPPDSKELEAIFGRPVVDGAEGESHSVSPWARP 298 Query: 922 ---------------LSFYELLEAIVDQPPPSAPADQFSPEFCSFISSCIQKDPAERKSA 1056 ++ +ELL+ IV++PPP P F+ +F F++ C+ K+PAER Sbjct: 299 PGRPISGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTQDFQEFVNKCLIKNPAERADL 358 Query: 1057 SELLNHAFIKKFEDKDLD 1110 L+NH FIK+ E +++D Sbjct: 359 KMLMNHTFIKRSEVEEVD 376
>P36506:MP2K2_RAT Dual specificity mitogen-activated protein kinase kinase 2 - Rattus| norvegicus (Rat) Length = 400 Score = 234 bits (597), Expect = 7e-61 Identities = 137/378 (36%), Positives = 207/378 (54%), Gaps = 54/378 (14%) Frame = +1 Query: 139 AQETPVDKFLTASGTFKDGELRLNQRGLQL--------ISEENGDEHQSTKM------KV 276 A+ PV LT + T +G ++ + + E + DE Q ++ K Sbjct: 3 ARRKPVLPALTINPTIAEGPSPTSEGASEAHLVDLQKKLEELDLDEQQRKRLEAFLTQKA 62 Query: 277 EDVQLSMDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQIVQELKIN 456 + +L DD E I +G G+GGVV RH+ G A K I + I+ +VR QI++EL++ Sbjct: 63 KVGELKDDDFERISELGAGNGGVVTKARHRPSGLIMARKLIHLEIKPAVRNQIIRELQVL 122 Query: 457 QATQSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLL 636 SP+IV + +FY +G I + +E+MD GSL ++K+ K I E L + VL GL Sbjct: 123 HECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEDILGKVSIAVLRGLA 182 Query: 637 YLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERIS 816 YL + ++HRD+KPSN+LVN +GE+K+ DFGVS L S+ ++FVGT +YM+PER+ Sbjct: 183 YLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA--NSFVGTRSYMSPERLQ 240 Query: 817 GSSYDYKSDVWSLGLVILECAIGRFPYTPPE----------------------------- 909 G+ Y +SD+WS+GL ++E AIGR+P PP+ Sbjct: 241 GTHYSVQSDIWSMGLSLVELAIGRYPIPPPDAKELEASFGRPVVDGADGEPHSVSPRPRP 300 Query: 910 ------GEGW-----LSFYELLEAIVDQPPPSAPADQFSPEFCSFISSCIQKDPAERKSA 1056 G G ++ +ELL+ IV++PPP P+ FS +F F++ C+ K+PAER Sbjct: 301 PGRPISGHGMDSRPAMAIFELLDYIVNEPPPKLPSGVFSSDFQEFVNKCLIKNPAERADL 360 Query: 1057 SELLNHAFIKKFEDKDLD 1110 L NHAFIK+ E +D+D Sbjct: 361 KLLTNHAFIKRSEGEDVD 378
>Q63932:MP2K2_MOUSE Dual specificity mitogen-activated protein kinase kinase 2 - Mus| musculus (Mouse) Length = 401 Score = 234 bits (596), Expect = 9e-61 Identities = 139/385 (36%), Positives = 212/385 (55%), Gaps = 47/385 (12%) Frame = +1 Query: 97 RGKKPLKELTLSVPAQETPVDKFLTASGTFKDGELRLNQRGLQLISEENGDEHQSTKM-- 270 R K L LT++ E P T+ G + + L ++ + E + DE Q ++ Sbjct: 4 RRKPVLPALTINPTIAEGPSP---TSEGASEANLVDLQKK----LEELDLDEQQRKRLEA 56 Query: 271 ----KVEDVQLSMDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQIV 438 K + +L DD E I +G G+GGVV RH+ G A K I + I+ +VR QI+ Sbjct: 57 FLTQKAKVGELKDDDFERISELGAGNGGVVTKARHRPSGFIMARKLIHLEIKPAVRNQII 116 Query: 439 QELKINQATQSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQ 618 +EL++ SP+IV + +FY +G I + +E+MD GSL ++K+ K I E L + Sbjct: 117 RELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEDILGKVSIA 176 Query: 619 VLEGLLYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYM 798 VL GL YL + ++HRD+KPSN+LVN +GE+K+ DFGVS L S+ ++FVGT +YM Sbjct: 177 VLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA--NSFVGTRSYM 234 Query: 799 APERISGSSYDYKSDVWSLGLVILECAIGRFPYTPPE----------------------- 909 +PER+ G+ Y +SD+WS+GL ++E AIGR+P PP+ Sbjct: 235 SPERLQGTHYSVQSDIWSMGLSLVELAIGRYPIPPPDAKELEASFGRPVVDGADGEPHSV 294 Query: 910 -------------GEGW-----LSFYELLEAIVDQPPPSAPADQFSPEFCSFISSCIQKD 1035 G G ++ +ELL+ IV++PPP P+ FS +F F++ C+ K+ Sbjct: 295 SPRPRPPGRPISVGHGMDSRPAMAIFELLDYIVNEPPPKLPSGVFSSDFQEFVNKCLIKN 354 Query: 1036 PAERKSASELLNHAFIKKFEDKDLD 1110 PAER L+NHAFIK+ E +++D Sbjct: 355 PAERADLKLLMNHAFIKRSEGEEVD 379
>P36507:MP2K2_HUMAN Dual specificity mitogen-activated protein kinase kinase 2 - Homo| sapiens (Human) Length = 400 Score = 233 bits (593), Expect = 2e-60 Identities = 137/384 (35%), Positives = 210/384 (54%), Gaps = 46/384 (11%) Frame = +1 Query: 97 RGKKPLKELTLSVPAQETPVDKFLTASGTFKDGELRLNQRGLQLISEENGDEHQSTKM-- 270 R K L LT++ E P T+ G + + L ++ + E DE Q ++ Sbjct: 4 RRKPVLPALTINPTIAEGPSP---TSEGASEANLVDLQKK----LEELELDEQQKKRLEA 56 Query: 271 ----KVEDVQLSMDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQIV 438 K + +L DD E I +G G+GGVV V+H+ G A K I + I+ ++R QI+ Sbjct: 57 FLTQKAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQII 116 Query: 439 QELKINQATQSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQ 618 +EL++ SP+IV + +FY +G I + +E+MD GSL ++K+ K I E L + Sbjct: 117 RELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIA 176 Query: 619 VLEGLLYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYM 798 VL GL YL + ++HRD+KPSN+LVN +GE+K+ DFGVS L S+ ++FVGT +YM Sbjct: 177 VLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA--NSFVGTRSYM 234 Query: 799 APERISGSSYDYKSDVWSLGLVILECAIGRFPYTPPE----------------------- 909 APER+ G+ Y +SD+WS+GL ++E A+GR+P PP+ Sbjct: 235 APERLQGTHYSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDGEEGEPHSI 294 Query: 910 ------------GEGW-----LSFYELLEAIVDQPPPSAPADQFSPEFCSFISSCIQKDP 1038 G G ++ +ELL+ IV++PPP P F+P+F F++ C+ K+P Sbjct: 295 SPRPRPPGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKNP 354 Query: 1039 AERKSASELLNHAFIKKFEDKDLD 1110 AER L NH FIK+ E +++D Sbjct: 355 AERADLKMLTNHTFIKRSEVEEVD 378
>Q24324:DSOR1_DROME Dual specificity mitogen-activated protein kinase kinase dSOR1 -| Drosophila melanogaster (Fruit fly) Length = 396 Score = 228 bits (582), Expect = 4e-59 Identities = 141/371 (38%), Positives = 209/371 (56%), Gaps = 31/371 (8%) Frame = +1 Query: 139 AQETPVDKFLTASGTFKDGELRLNQRGLQLISE-----ENGD-EHQSTKM----KVEDVQ 288 A P F T SGT L + + ++E + GD E + KM K + + Sbjct: 22 ATVAPTPPFKTPSGTDTHSLLGKPKTSIDALTETLEGLDMGDTERKRIKMFLSQKEKIGE 81 Query: 289 LSMDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQIVQELKINQATQ 468 LS +DLE + +G G+GGVV VRH A K I + ++ +++KQI++ELK+ Sbjct: 82 LSDEDLEKLGELGSGNGGVVMKVRHTHTHLIMARKLIHLEVKPAIKKQILRELKVLHECN 141 Query: 469 SPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLYLHH 648 PHIV + +FY +G I + +EYMD GSL I+K+ I E L + VL+GL YL Sbjct: 142 FPHIVGFYGAFYSDGEISICMEYMDGGSLDLILKRAGRIPESILGRITLAVLKGLSYLRD 201 Query: 649 ERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISGSSY 828 +IHRD+KPSN+LVN GE+KI DFGVS L S+ ++FVGT +YM+PER+ G+ Y Sbjct: 202 NHAIIHRDVKPSNILVNSSGEIKICDFGVSGQLIDSMA--NSFVGTRSYMSPERLQGTHY 259 Query: 829 DYKSDVWSLGLVILECAIGRFPYTPP-------------EGEGW-------LSFYELLEA 948 +SD+WSLGL ++E AIG +P PP E G ++ +ELL+ Sbjct: 260 SVQSDIWSLGLSLVEMAIGMYPIPPPNTATLESIFADNAEESGQPTDEPRAMAIFELLDY 319 Query: 949 IVDQPPPSAPADQFSPEFCSFISSCIQKDPAERKSASELLNHAFIKKFEDKDLDLRILV- 1125 IV++PPP FS EF F+ C++K P ER LL+H +I+K E +++D+ V Sbjct: 320 IVNEPPPKLEHKIFSTEFKDFVDICLKKQPDERADLKTLLSHPWIRKAELEEVDISGWVC 379 Query: 1126 ESLEQPMNVPE 1158 ++++ P + P+ Sbjct: 380 KTMDLPPSTPK 390
>Q1HG70:MP2K2_CANFA Dual specificity mitogen-activated protein kinase kinase 2 - Canis| familiaris (Dog) Length = 400 Score = 227 bits (578), Expect = 1e-58 Identities = 135/384 (35%), Positives = 211/384 (54%), Gaps = 46/384 (11%) Frame = +1 Query: 97 RGKKPLKELTLSVPAQETPVDKFLTASGTFKDGELRLNQRGLQLISEENGDEHQSTKM-- 270 R K L LT++ E P T+ G + + L ++ ++E DE Q ++ Sbjct: 4 RRKPVLPALTINPAIAEGPSP---TSEGASEANLVDLQKK----LAELELDEQQKKRLEA 56 Query: 271 ----KVEDVQLSMDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQIV 438 K + +L DD E I +G G+GGVV V+H+ G A K I + I+ ++R QI+ Sbjct: 57 FLTQKAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQII 116 Query: 439 QELKINQATQSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQ 618 +EL++ SP+IV + +FY +G I + +E+MD GSL ++K+ K I E L + Sbjct: 117 RELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIA 176 Query: 619 VLEGLLYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYM 798 VL GL YL + ++HRD+KPSN+LVN +GE+K+ DFGVS L S+ ++FVGT +YM Sbjct: 177 VLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA--NSFVGTRSYM 234 Query: 799 APERISGSSYDYKSDVWSLGLVILECAIGRFPYTPP-----------------EGEGW-- 921 +PER+ G+ Y +SD+WS+GL ++E +IGR+P PP EGE Sbjct: 235 SPERLQGTHYSVQSDIWSMGLSLVELSIGRYPIPPPDAKELEAIFGRPMVDGIEGEPHSI 294 Query: 922 ---------------------LSFYELLEAIVDQPPPSAPADQFSPEFCSFISSCIQKDP 1038 ++ +ELL+ IV++PPP P F+ +F F++ C+ K+P Sbjct: 295 SPRPRPPGRPISGHGTDSRPAMAIFELLDYIVNEPPPKLPNGVFTQDFQEFVNKCLIKNP 354 Query: 1039 AERKSASELLNHAFIKKFEDKDLD 1110 AER L++H FIK+ E +++D Sbjct: 355 AERADLKMLMSHTFIKRSEVEEVD 378
>Q01986:MP2K1_RAT Dual specificity mitogen-activated protein kinase kinase 1 - Rattus| norvegicus (Rat) Length = 393 Score = 226 bits (575), Expect = 2e-58 Identities = 132/368 (35%), Positives = 202/368 (54%), Gaps = 43/368 (11%) Frame = +1 Query: 136 PAQETPVDKFLTASGTFKDGELRLNQRGLQLISEE-NGDEHQSTKM------KVEDVQLS 294 P Q P +GT N LQ EE DE Q ++ K + +L Sbjct: 8 PIQLNPAPDGSAVNGT---SSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKVGELK 64 Query: 295 MDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQIVQELKINQATQSP 474 DD E I +G G+GGVV V HK G A K I + I+ ++R QI++EL++ SP Sbjct: 65 DDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSP 124 Query: 475 HIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLYLHHER 654 +IV + +FY +G I + +E+MD GSL ++K+ I E L + V++GL YL + Sbjct: 125 YIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKH 184 Query: 655 HVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISGSSYDY 834 ++HRD+KPSN+LVN +GE+K+ DFGVS L S+ ++FVGT +YM+PER+ G+ Y Sbjct: 185 KIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA--NSFVGTRSYMSPERLQGTHYSV 242 Query: 835 KSDVWSLGLVILECAIGRFPYTPPEGEGW------------------------------- 921 +SD+WS+GL ++E A+GR+P PP+ + Sbjct: 243 QSDIWSMGLSLVEMAVGRYPIPPPDAKELELLFGCQVEGDAAETPPRPRTPGRPLSSYGM 302 Query: 922 -----LSFYELLEAIVDQPPPSAPADQFSPEFCSFISSCIQKDPAERKSASELLNHAFIK 1086 ++ +ELL+ IV++PPP P+ FS EF F++ C+ K+PAER +L+ HAFIK Sbjct: 303 DSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIK 362 Query: 1087 KFEDKDLD 1110 + + +++D Sbjct: 363 RSDAEEVD 370
>P31938:MP2K1_MOUSE Dual specificity mitogen-activated protein kinase kinase 1 - Mus| musculus (Mouse) Length = 393 Score = 226 bits (575), Expect = 2e-58 Identities = 132/368 (35%), Positives = 202/368 (54%), Gaps = 43/368 (11%) Frame = +1 Query: 136 PAQETPVDKFLTASGTFKDGELRLNQRGLQLISEE-NGDEHQSTKM------KVEDVQLS 294 P Q P +GT N LQ EE DE Q ++ K + +L Sbjct: 8 PIQLNPAPDGSAVNGT---SSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKVGELK 64 Query: 295 MDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQIVQELKINQATQSP 474 DD E I +G G+GGVV V HK G A K I + I+ ++R QI++EL++ SP Sbjct: 65 DDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSP 124 Query: 475 HIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLYLHHER 654 +IV + +FY +G I + +E+MD GSL ++K+ I E L + V++GL YL + Sbjct: 125 YIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKH 184 Query: 655 HVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISGSSYDY 834 ++HRD+KPSN+LVN +GE+K+ DFGVS L S+ ++FVGT +YM+PER+ G+ Y Sbjct: 185 KIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA--NSFVGTRSYMSPERLQGTHYSV 242 Query: 835 KSDVWSLGLVILECAIGRFPYTPPEGEGW------------------------------- 921 +SD+WS+GL ++E A+GR+P PP+ + Sbjct: 243 QSDIWSMGLSLVEMAVGRYPIPPPDAKELELLFGCHVEGDAAETPPRPRTPGRPLSSYGM 302 Query: 922 -----LSFYELLEAIVDQPPPSAPADQFSPEFCSFISSCIQKDPAERKSASELLNHAFIK 1086 ++ +ELL+ IV++PPP P+ FS EF F++ C+ K+PAER +L+ HAFIK Sbjct: 303 DSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIK 362 Query: 1087 KFEDKDLD 1110 + + +++D Sbjct: 363 RSDAEEVD 370
>Q02750:MP2K1_HUMAN Dual specificity mitogen-activated protein kinase kinase 1 - Homo| sapiens (Human) Length = 393 Score = 226 bits (575), Expect = 2e-58 Identities = 132/368 (35%), Positives = 202/368 (54%), Gaps = 43/368 (11%) Frame = +1 Query: 136 PAQETPVDKFLTASGTFKDGELRLNQRGLQLISEE-NGDEHQSTKM------KVEDVQLS 294 P Q P +GT N LQ EE DE Q ++ K + +L Sbjct: 8 PIQLNPAPDGSAVNGT---SSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKVGELK 64 Query: 295 MDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQIVQELKINQATQSP 474 DD E I +G G+GGVV V HK G A K I + I+ ++R QI++EL++ SP Sbjct: 65 DDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSP 124 Query: 475 HIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLYLHHER 654 +IV + +FY +G I + +E+MD GSL ++K+ I E L + V++GL YL + Sbjct: 125 YIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKH 184 Query: 655 HVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISGSSYDY 834 ++HRD+KPSN+LVN +GE+K+ DFGVS L S+ ++FVGT +YM+PER+ G+ Y Sbjct: 185 KIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA--NSFVGTRSYMSPERLQGTHYSV 242 Query: 835 KSDVWSLGLVILECAIGRFPYTPPEGEGW------------------------------- 921 +SD+WS+GL ++E A+GR+P PP+ + Sbjct: 243 QSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGM 302 Query: 922 -----LSFYELLEAIVDQPPPSAPADQFSPEFCSFISSCIQKDPAERKSASELLNHAFIK 1086 ++ +ELL+ IV++PPP P+ FS EF F++ C+ K+PAER +L+ HAFIK Sbjct: 303 DSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIK 362 Query: 1087 KFEDKDLD 1110 + + +++D Sbjct: 363 RSDAEEVD 370
>P29678:MP2K1_RABIT Dual specificity mitogen-activated protein kinase kinase 1 -| Oryctolagus cuniculus (Rabbit) Length = 393 Score = 225 bits (574), Expect = 3e-58 Identities = 132/368 (35%), Positives = 202/368 (54%), Gaps = 43/368 (11%) Frame = +1 Query: 136 PAQETPVDKFLTASGTFKDGELRLNQRGLQLISEE-NGDEHQSTKM------KVEDVQLS 294 P Q P +GT N LQ EE DE Q ++ K + +L Sbjct: 8 PIQLNPAPDGSAVNGT---SSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKVGELK 64 Query: 295 MDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQIVQELKINQATQSP 474 DD E I +G G+GGVV V HK G A K I + I+ ++R QI++EL++ SP Sbjct: 65 DDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSP 124 Query: 475 HIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLYLHHER 654 +IV + +FY +G I + +E+MD GSL ++K+ I E L + V++GL YL + Sbjct: 125 YIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKH 184 Query: 655 HVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISGSSYDY 834 ++HRD+KPSN+LVN +GE+K+ DFGVS L S+ ++FVGT +YM+PER+ G+ Y Sbjct: 185 KIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA--NSFVGTRSYMSPERLQGTHYSV 242 Query: 835 KSDVWSLGLVILECAIGRFPYTPPEGEGW------------------------------- 921 +SD+WS+GL ++E A+GR+P PP+ + Sbjct: 243 QSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGM 302 Query: 922 -----LSFYELLEAIVDQPPPSAPADQFSPEFCSFISSCIQKDPAERKSASELLNHAFIK 1086 ++ +ELL+ IV++PPP P+ FS EF F++ C+ K+PAER +L+ HAFIK Sbjct: 303 DSRPPMAIFELLDYIVNEPPPKLPSAVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIK 362 Query: 1087 KFEDKDLD 1110 + + +++D Sbjct: 363 RSDAEEVD 370
>Q91447:MP2K1_SERCA Dual specificity mitogen-activated protein kinase kinase 1 - Serinus| canaria (Canary) Length = 388 Score = 225 bits (573), Expect = 4e-58 Identities = 133/370 (35%), Positives = 200/370 (54%), Gaps = 45/370 (12%) Frame = +1 Query: 136 PAQETPVDKFLTASGTFKDGELRLNQRGLQLISEE-NGDEHQSTKM------KVEDVQLS 294 P Q P +GT N LQ EE DE Q ++ K + +L Sbjct: 1 PIQLNPAPDGSAVNGT---SSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKVGELK 57 Query: 295 MDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQIVQELKINQATQSP 474 DD E I +G G+GGVV V HK G A K I + I+ ++R QI++EL++ SP Sbjct: 58 DDDFEKISELGAGNGGVVFKVSHKPSGLIMARKLIHLEIKPAIRNQIIRELQVLHECNSP 117 Query: 475 HIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLYLHHER 654 +IV + +FY +G I + +E+MD GSL ++K+ I E L + V++GL YL + Sbjct: 118 YIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKH 177 Query: 655 HVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISGSSYDY 834 ++HRD+KPSN+LVN +GE+K+ DFGVS L S+ ++FVGT +YM+PER+ G+ Y Sbjct: 178 KIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA--NSFVGTRSYMSPERLQGTHYSV 235 Query: 835 KSDVWSLGLVILECAIGRFPYTPPEGEGW------------------------------- 921 +SD+WS+GL ++E AIGR+P PP+ + Sbjct: 236 QSDIWSMGLSLVEMAIGRYPIPPPDSKELELMFGCPVEGDSPVTETSPRQRAPGRPMSSY 295 Query: 922 -------LSFYELLEAIVDQPPPSAPADQFSPEFCSFISSCIQKDPAERKSASELLNHAF 1080 ++ +ELL+ IV++PPP P F EF F++ C+ K+PAER +L+ HAF Sbjct: 296 GSDSRPPMAIFELLDYIVNEPPPKLPNGVFGSEFQDFVNKCLIKNPAERADLKQLMIHAF 355 Query: 1081 IKKFEDKDLD 1110 IK+ E +++D Sbjct: 356 IKRSEAEEVD 365
>Q05116:MP2K1_XENLA Dual specificity mitogen-activated protein kinase kinase 1 - Xenopus| laevis (African clawed frog) Length = 395 Score = 223 bits (568), Expect = 2e-57 Identities = 128/374 (34%), Positives = 205/374 (54%), Gaps = 38/374 (10%) Frame = +1 Query: 103 KKPLKELTLSVPAQETPVDKFLTASGTFKDGELRLNQRGLQLISEENGDEHQSTKMKVED 282 KK + L+ + T V+ TA + + +L + L + + + K KV + Sbjct: 3 KKKPTPIQLNPNPEGTAVNGTPTAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKVGE 62 Query: 283 VQLSMDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQIVQELKINQA 462 L DD E + +G G+GGVV V HK A K I + I+ ++R QI++EL++ Sbjct: 63 --LKDDDFEKVSELGAGNGGVVFKVSHKPTSLIMARKLIHLEIKPAIRNQIIRELQVLHE 120 Query: 463 TQSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLYL 642 SP+IV + +FY +G I + +E+MD GSL ++K+ I E L + V++GL YL Sbjct: 121 CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGKIPEKILGKVSIAVIKGLTYL 180 Query: 643 HHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISGS 822 + ++HRD+KPSN+LVN +GE+K+ DFGVS L S+ ++FVGT +YM+PER+ G+ Sbjct: 181 REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA--NSFVGTRSYMSPERLQGT 238 Query: 823 SYDYKSDVWSLGLVILECAIGRFPYTPPEGEGW--------------------------- 921 Y +SD+WS+GL ++E AIGR+P PP+ + Sbjct: 239 HYSVQSDIWSMGLSLVEMAIGRYPIPPPDAKELELIFGCSVERDPASSELAPRPRPPGRP 298 Query: 922 -----------LSFYELLEAIVDQPPPSAPADQFSPEFCSFISSCIQKDPAERKSASELL 1068 ++ +ELL+ IV++PPP P+ F EF F++ C+ K+PAER +L+ Sbjct: 299 ISSYGPDSRPPMAIFELLDYIVNEPPPKLPSGVFGAEFQDFVNKCLVKNPAERADLKQLM 358 Query: 1069 NHAFIKKFEDKDLD 1110 H+FIK+ E +++D Sbjct: 359 VHSFIKQSELEEVD 372
>Q90321:MP2K2_CYPCA Dual specificity mitogen-activated protein kinase kinase 2 - Cyprinus| carpio (Common carp) Length = 397 Score = 222 bits (566), Expect = 3e-57 Identities = 128/354 (36%), Positives = 196/354 (55%), Gaps = 47/354 (13%) Frame = +1 Query: 190 DGELRLNQRGLQL-ISEENGDEHQSTKM------KVEDVQLSMDDLEMIQVIGKGSGGVV 348 D N LQ + E + DE Q ++ K + +L +D + I +G G+GGVV Sbjct: 24 DAASEANLEALQRKLGELDLDEQQRKRLEAFLTQKAQVGELKDEDFDPICELGAGNGGVV 83 Query: 349 QLVRHKWVGTFYALKGIQMNIQESVRKQIVQELKINQATQSPHIVLCHQSFYHNGVIYLV 528 VRHK A K I + I+ ++R QI++EL++ SP+IV + +FY +G I + Sbjct: 84 HKVRHKPSRLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISIC 143 Query: 529 LEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLYLHHERHVIHRDIKPSNLLVNHKG 708 +E+MD GSL ++K+ + I E L + VL GL+YL + ++HRD+KPSN+LVN +G Sbjct: 144 MEHMDGGSLDQVLKEARRIPEEILGKVSIAVLRGLVYLREKHQIMHRDVKPSNILVNSRG 203 Query: 709 EVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISGSSYDYKSDVWSLGLVILECAIGR 888 E+K+ DFGVS L S+ ++FVGT +YM+PER+ G+ Y +SDVWS+GL ++E AIGR Sbjct: 204 EIKLCDFGVSGQLIDSMA--NSFVGTRSYMSPERLQGTHYSVQSDVWSMGLSLVELAIGR 261 Query: 889 FPYTPPE-----------------------------------GEGW-----LSFYELLEA 948 FP PP+ G G ++ +ELL+ Sbjct: 262 FPIPPPDAKELEAIFGRPVLDKGGAEGHSMSPRQRPPGRPVSGHGMDSRPAMAIFELLDY 321 Query: 949 IVDQPPPSAPADQFSPEFCSFISSCIQKDPAERKSASELLNHAFIKKFEDKDLD 1110 IV++PPP P F+ +F F+ C+ K+PA+R L+ H FIK+ E +++D Sbjct: 322 IVNEPPPKLPHGVFTTDFEEFVMKCLMKNPADRADLKMLMGHTFIKRAEVEEVD 375
>Q63980:MP2K1_CRIGR Dual specificity mitogen-activated protein kinase kinase 1 -| Cricetulus griseus (Chinese hamster) Length = 393 Score = 222 bits (565), Expect = 3e-57 Identities = 131/366 (35%), Positives = 199/366 (54%), Gaps = 45/366 (12%) Frame = +1 Query: 148 TPVDKFLTASGTFKDG--ELRLNQRGLQLISEENGDEHQSTK-------MKVEDVQLSMD 300 TP+ T G+ +G N LQ EE E Q K + +L D Sbjct: 7 TPIQLNPTPDGSAVNGTSSAETNLEALQKKLEELELEEQQRNRLEAFLTQKQKVGELKDD 66 Query: 301 DLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQIVQELKINQATQSPHI 480 D E I +G G+GGVV V HK G A K I + I+ ++R QI++EL++ SP+I Sbjct: 67 DFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYI 126 Query: 481 VLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLYLHHERHV 660 V + FY +G I + +E+MD GSL ++K+ I E L + V++GL YL + + Sbjct: 127 VGFYGVFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKI 186 Query: 661 IHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISGSSYDYKS 840 +HRD+KPSN+LVN +GE+K+ DFGVS L S+ ++FVGT +YM+PER+ G+ Y +S Sbjct: 187 MHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA--NSFVGTRSYMSPERLQGTHYSVQS 244 Query: 841 DVWSLGLVILECAIGRFPYTPPEGEGW--------------------------------- 921 D+WS+GL ++E A+GR+P PP+ + Sbjct: 245 DIWSMGLSLVEMAVGRYPIPPPDAKELELLFGCQVEGDAAETPPRPRTPGRPLSSYGMDS 304 Query: 922 ---LSFYELLEAIVDQPPPSAPADQFSPEFCSFISSCIQKDPAERKSASELLNHAFIKKF 1092 ++ +ELL+ IV++PP P+ FS EF F++ C+ K+PAER +LL HAFIK+ Sbjct: 305 RPPMAIFELLDYIVNEPPAKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLLVHAFIKRS 364 Query: 1093 EDKDLD 1110 + +++D Sbjct: 365 DAEEVD 370
>Q9XT09:MP2K1_PANTR Dual specificity mitogen-activated protein kinase kinase 1 - Pan| troglodytes (Chimpanzee) Length = 393 Score = 218 bits (556), Expect = 4e-56 Identities = 132/368 (35%), Positives = 200/368 (54%), Gaps = 43/368 (11%) Frame = +1 Query: 136 PAQETPVDKFLTASGTFKDGELRLNQRGLQLISEE-NGDEHQSTKM------KVEDVQLS 294 P Q P +GT N LQ EE DE Q ++ K + +L Sbjct: 8 PIQLNPAPDGSAVNGT---SSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKVGELK 64 Query: 295 MDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQIVQELKINQATQSP 474 DD E I +G G+GGVV V HK G A K I + I+ ++R QI++EL++ SP Sbjct: 65 DDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSP 124 Query: 475 HIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLYLHHER 654 +IV + +FY +G I + +E+MD GSL ++K+ I E L + V++GL YL + Sbjct: 125 YIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKH 184 Query: 655 HVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISGSSYDY 834 ++HRD++PSN+LVN +GE+K+ DFGVS L S+ ++FVGT +YM+PER G+ Y Sbjct: 185 KIMHRDVQPSNILVNSRGEIKLCDFGVSGQLIDSMA--NSFVGTRSYMSPERFQGTHYSV 242 Query: 835 KSDVWSLGLVILECAIGRFPY----------------------TPP-------------- 906 +SD+WS+GL +E A+GR+P TPP Sbjct: 243 QSDIWSMGLSPVEMAVGRYPIPSPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGM 302 Query: 907 EGEGWLSFYELLEAIVDQPPPSAPADQFSPEFCSFISSCIQKDPAERKSASELLNHAFIK 1086 + ++ +ELL+ IV++PPP P+ FS EF F++ C+ K+PAER +L+ HAFIK Sbjct: 303 DSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIK 362 Query: 1087 KFEDKDLD 1110 + + +++D Sbjct: 363 RSDAEEVD 370
>Q8RXG3:M2K5_ARATH Mitogen-activated protein kinase kinase 5 - Arabidopsis thaliana| (Mouse-ear cress) Length = 348 Score = 212 bits (540), Expect = 3e-54 Identities = 124/271 (45%), Positives = 165/271 (60%), Gaps = 5/271 (1%) Frame = +1 Query: 292 SMDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQIVQELKINQATQS 471 S+ +LE + IG G+GG V V H +ALK I N +++VR+QI +E++I ++ Sbjct: 66 SLSELERVNRIGSGAGGTVYKVIHTPTSRPFALKVIYGNHEDTVRRQICREIEILRSVDH 125 Query: 472 PHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLYLHHE 651 P++V CH F HNG I ++LE+MD+GSL + E LA L +Q+L GL YL H Sbjct: 126 PNVVKCHDMFDHNGEIQVLLEFMDQGSL----EGAHIWQEQELADLSRQILSGLAYL-HR 180 Query: 652 RHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERIS----- 816 RH++HRDIKPSNLL+N VKI DFGVS +LA ++ ++ VGT YM+PERI+ Sbjct: 181 RHIVHRDIKPSNLLINSAKNVKIADFGVSRILAQTMDPCNSSVGTIAYMSPERINTDLNH 240 Query: 817 GSSYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAPADQFSP 996 G Y DVWSLG+ ILE +GRFP+ W S L+ AI PP APA S Sbjct: 241 GRYDGYAGDVWSLGVSILEFYLGRFPFAVSRQGDWAS---LMCAICMSQPPEAPATA-SQ 296 Query: 997 EFCSFISSCIQKDPAERKSASELLNHAFIKK 1089 EF F+S C+Q DP +R SA +LL H FI K Sbjct: 297 EFRHFVSCCLQSDPPKRWSAQQLLQHPFILK 327
>O80397:M2K4_ARATH Mitogen-activated protein kinase kinase 4 - Arabidopsis thaliana| (Mouse-ear cress) Length = 366 Score = 212 bits (540), Expect = 3e-54 Identities = 126/286 (44%), Positives = 168/286 (58%), Gaps = 5/286 (1%) Frame = +1 Query: 241 NGDEHQSTKMKVEDVQLSMDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQES 420 +G ST + DL IG G+GG V V H+ YALK I N +E+ Sbjct: 58 SGGSASSTNTNSSIEAKNYSDLVRGNRIGSGAGGTVYKVIHRPSSRLYALKVIYGNHEET 117 Query: 421 VRKQIVQELKINQATQSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYL 600 VR+QI +E++I + P++V CH+ F NG I ++LE+MD+GSL + E L Sbjct: 118 VRRQICREIEILRDVNHPNVVKCHEMFDQNGEIQVLLEFMDKGSL----EGAHVWKEQQL 173 Query: 601 AVLCKQVLEGLLYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFV 780 A L +Q+L GL YL H RH++HRDIKPSNLL+N VKI DFGVS +LA ++ ++ V Sbjct: 174 ADLSRQILSGLAYL-HSRHIVHRDIKPSNLLINSAKNVKIADFGVSRILAQTMDPCNSSV 232 Query: 781 GTYNYMAPERIS-----GSSYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLE 945 GT YM+PERI+ G Y D+WSLG+ ILE +GRFP+ W S L+ Sbjct: 233 GTIAYMSPERINTDLNQGKYDGYAGDIWSLGVSILEFYLGRFPFPVSRQGDWAS---LMC 289 Query: 946 AIVDQPPPSAPADQFSPEFCSFISSCIQKDPAERKSASELLNHAFI 1083 AI PP APA SPEF FIS C+Q++P +R+SA +LL H FI Sbjct: 290 AICMSQPPEAPATA-SPEFRHFISCCLQREPGKRRSAMQLLQHPFI 334
>Q10664:MEK2_CAEEL Dual specificity mitogen-activated protein kinase kinase mek-2 -| Caenorhabditis elegans Length = 387 Score = 205 bits (522), Expect = 3e-52 Identities = 126/375 (33%), Positives = 191/375 (50%), Gaps = 30/375 (8%) Frame = +1 Query: 70 PSHSKEEAMRGKKPLKELTLSVPAQETPVDKFLTASGTFKDGELRLNQRGLQLISEENGD 249 P E++ G+ +E T +VP +E LT T + E + G++ +SE Sbjct: 15 PPTVNEQSESGEATAEEATATVPLEEQLKKLGLTEPQTQRLSEFLQVKEGIKELSE---- 70 Query: 250 EHQSTKMKVEDVQLSMDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRK 429 D L+ +G G+GGVV H+ G A K + + I+ SVR+ Sbjct: 71 ----------------DMLQTEGELGHGNGGVVNKCVHRKTGVIMARKLVHLEIKPSVRQ 114 Query: 430 QIVQELKINQATQSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVL 609 QIV+EL + SP IV + +F N I + +EYMD SL ++K+V + E ++ + Sbjct: 115 QIVKELAVLHKCNSPFIVGFYGAFVDNNDISICMEYMDGLSLDIVLKKVGRLPEKFVGRI 174 Query: 610 CKQVLEGLLYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTY 789 V+ GL YL E ++HRD+KPSN+LVN GE+K+ DFGVS +L S+ ++FVGT Sbjct: 175 SVAVVRGLTYLKDEIKILHRDVKPSNMLVNSNGEIKLCDFGVSGMLIDSMA--NSFVGTR 232 Query: 790 NYMAPERISGSSYDYKSDVWSLGLVILECAIGRFP------------------------- 894 +YMAPER++GS Y SD+WS GL ++E IGR+P Sbjct: 233 SYMAPERLTGSHYTISSDIWSFGLSLVELLIGRYPVPAPSQAEYATMFNVAENEIELADS 292 Query: 895 -----YTPPEGEGWLSFYELLEAIVDQPPPSAPADQFSPEFCSFISSCIQKDPAERKSAS 1059 Y PP ++ +E+L+ IV+ PPP+ P F+ E F+S C++K P+ER + Sbjct: 293 LEEPNYHPPSNPASMAIFEMLDYIVNGPPPTLPKRFFTDEVIGFVSKCLRKLPSERATLK 352 Query: 1060 ELLNHAFIKKFEDKD 1104 L F ++ D D Sbjct: 353 SLTADVFFTQYADHD 367
>P08018:PBS2_YEAST MAP kinase kinase PBS2 - Saccharomyces cerevisiae (Baker's yeast)| Length = 668 Score = 203 bits (516), Expect = 2e-51 Identities = 119/326 (36%), Positives = 189/326 (57%), Gaps = 10/326 (3%) Frame = +1 Query: 193 GELRLNQRGLQLISEENGDEHQSTKMKVEDVQLSMDDLEMIQVIGKGSGGVVQLVRHKWV 372 G+L L+ +G+ NG + T +D+LE + +G G+ G V V HK Sbjct: 336 GKLSLSSKGIDF---SNGSSSRIT----------LDELEFLDELGHGNYGNVSKVLHKPT 382 Query: 373 GTFYALKGIQMNIQESVRKQIVQELKINQATQSPHIVLCHQSFYHNGVIYLVLEYMDRGS 552 A K +++ + E+ +QI+ EL++ SP+IV + +F+ G +Y+ +EYMD GS Sbjct: 383 NVIMATKEVRLELDEAKFRQILMELEVLHKCNSPYIVDFYGAFFIEGAVYMCMEYMDGGS 442 Query: 553 LADII---KQVKTILEPYLAVLCKQVLEGLLYLHHERHVIHRDIKPSNLLVN-HKGEVKI 720 L I ++ I EP LA + V+ GL L + ++IHRD+KP+N+L + ++G VK+ Sbjct: 443 LDKIYDESSEIGGIDEPQLAFIANAVIHGLKELKEQHNIIHRDVKPTNILCSANQGTVKL 502 Query: 721 TDFGVSAVLASSIGQRDTFVGTYNYMAPERISG-----SSYDYKSDVWSLGLVILECAIG 885 DFGVS L +S+ + T +G +YMAPERI ++Y +SD+WSLGL ILE A+G Sbjct: 503 CDFGVSGNLVASLAK--TNIGCQSYMAPERIKSLNPDRATYTVQSDIWSLGLSILEMALG 560 Query: 886 RFPYTPPEGEGWLSFYELLEAIVDQPPPSAPADQFSPEFCSFISSCIQKDPAERKSASEL 1065 R+PY P E + + + L AIVD PPP P+D+FS + F+S C+QK P R + + L Sbjct: 561 RYPYPP---ETYDNIFSQLSAIVDGPPPRLPSDKFSSDAQDFVSLCLQKIPERRPTYAAL 617 Query: 1066 LNHAFIKKFEDKDLDL-RILVESLEQ 1140 H ++ K+ ++D+ + + E LE+ Sbjct: 618 TEHPWLVKYRNQDVHMSEYITERLER 643
>P33886:WIS1_SCHPO Protein kinase wis1 - Schizosaccharomyces pombe (Fission yeast)| Length = 605 Score = 201 bits (511), Expect = 6e-51 Identities = 124/337 (36%), Positives = 189/337 (56%), Gaps = 7/337 (2%) Frame = +1 Query: 124 TLSVPAQETPVDKFLTASGTFKDGELRLNQRGLQLISEENGDEHQSTKMKVEDVQLSMDD 303 TL ETP F T S LN + +++ E + + ++ +M + Sbjct: 268 TLKQAVSETP---FSTFSDILDAKSGTLNFKNKAVLNSEGVNFSSGSSFRI-----NMSE 319 Query: 304 LEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQIVQELKINQATQSPHIV 483 + ++ +GKG+ GVV H+ G ALK I+++++E+ QI+ EL I SP+IV Sbjct: 320 IIKLEELGKGNYGVVYKALHQPTGVTMALKEIRLSLEEATFNQIIMELDILHKAVSPYIV 379 Query: 484 LCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLYLHHERHVI 663 + +F+ G +++ +EYMD GS+ D + E LA V++GL L E ++I Sbjct: 380 DFYGAFFVEGSVFICMEYMDAGSM-DKLYAGGIKDEGVLARTAYAVVQGLKTLKEEHNII 438 Query: 664 HRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISGS------- 822 HRD+KP+N+LVN G+VK+ DFGVS L +SI + T +G +YMAPERI Sbjct: 439 HRDVKPTNVLVNSNGQVKLCDFGVSGNLVASISK--TNIGCQSYMAPERIRVGGPTNGVL 496 Query: 823 SYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAPADQFSPEF 1002 +Y ++DVWSLGL ILE A+G +PY P E + S + L AI D PPS P D FSPE Sbjct: 497 TYTVQADVWSLGLTILEMALGAYPYPP---ESYTSIFAQLSAICDGDPPSLP-DSFSPEA 552 Query: 1003 CSFISSCIQKDPAERKSASELLNHAFIKKFEDKDLDL 1113 F++ C+ K+P+ R EL NH ++ K+++ D+D+ Sbjct: 553 RDFVNKCLNKNPSLRPDYHELANHPWLLKYQNADVDM 589
>Q13163:MP2K5_HUMAN Dual specificity mitogen-activated protein kinase kinase 5 - Homo| sapiens (Human) Length = 448 Score = 195 bits (496), Expect = 3e-49 Identities = 112/272 (41%), Positives = 164/272 (60%), Gaps = 1/272 (0%) Frame = +1 Query: 286 QLSMDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQIVQELKINQAT 465 Q++ D+ +G G+GG V H G A+K I ++I ++KQI+ EL+I Sbjct: 160 QMNEQDIRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKC 219 Query: 466 QSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLYLH 645 S +I+ + +F+ I + E+MD GSL D+ +++ E L + V++GL YL Sbjct: 220 DSSYIIGFYGAFFVENRISICTEFMDGGSL-DVYRKMP---EHVLGRIAVAVVKGLTYLW 275 Query: 646 HERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISGSS 825 + ++HRD+KPSN+LVN +G+VK+ DFGVS L +SI + T+VGT YMAPERISG Sbjct: 276 SLK-ILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAK--TYVGTNAYMAPERISGEQ 332 Query: 826 YDYKSDVWSLGLVILECAIGRFPYTP-PEGEGWLSFYELLEAIVDQPPPSAPADQFSPEF 1002 Y SDVWSLG+ +E A+GRFPY + +G L +LL+ IVD+ P P +FS F Sbjct: 333 YGIHSDVWSLGISFMELALGRFPYPQIQKNQGSLMPLQLLQCIVDEDSPVLPVGEFSEPF 392 Query: 1003 CSFISSCIQKDPAERKSASELLNHAFIKKFED 1098 FI+ C++K P ER + EL+ H FI +F D Sbjct: 393 VHFITQCMRKQPKERPAPEELMGHPFIVQFND 424
>Q62862:MP2K5_RAT Dual specificity mitogen-activated protein kinase kinase 5 - Rattus| norvegicus (Rat) Length = 448 Score = 195 bits (495), Expect = 4e-49 Identities = 112/272 (41%), Positives = 163/272 (59%), Gaps = 1/272 (0%) Frame = +1 Query: 286 QLSMDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQIVQELKINQAT 465 Q++ D+ +G G+GG V H G A+K I ++I ++KQI+ EL+I Sbjct: 160 QMNEQDIRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKC 219 Query: 466 QSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLYLH 645 S +I+ + +F+ I + E+MD GSL D+ +++ E L + V++GL YL Sbjct: 220 DSSYIIGFYGAFFVENRISICTEFMDGGSL-DVYRKIP---EHVLGRIAVAVVKGLTYLW 275 Query: 646 HERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISGSS 825 + ++HRD+KPSN+LVN G+VK+ DFGVS L +SI + T+VGT YMAPERISG Sbjct: 276 SLK-ILHRDVKPSNMLVNTSGQVKLCDFGVSTQLVNSIAK--TYVGTNAYMAPERISGEQ 332 Query: 826 YDYKSDVWSLGLVILECAIGRFPYTP-PEGEGWLSFYELLEAIVDQPPPSAPADQFSPEF 1002 Y SDVWSLG+ +E A+GRFPY + +G L +LL+ IVD+ P P +FS F Sbjct: 333 YGIHSDVWSLGISFMELALGRFPYPQIQKNQGSLMPLQLLQCIVDEDSPVLPLGEFSEPF 392 Query: 1003 CSFISSCIQKDPAERKSASELLNHAFIKKFED 1098 FI+ C++K P ER + EL+ H FI +F D Sbjct: 393 VHFITQCMRKQPKERPAPEELMGHPFIVQFND 424
>Q9WVS7:MP2K5_MOUSE Dual specificity mitogen-activated protein kinase kinase 5 - Mus| musculus (Mouse) Length = 448 Score = 195 bits (495), Expect = 4e-49 Identities = 112/272 (41%), Positives = 163/272 (59%), Gaps = 1/272 (0%) Frame = +1 Query: 286 QLSMDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQIVQELKINQAT 465 Q++ D+ +G G+GG V H G A+K I ++I ++KQI+ EL+I Sbjct: 160 QMNEQDIRYRDTLGHGNGGTVYKAHHVPSGKILAVKVILLDITLELQKQIMSELEILYKC 219 Query: 466 QSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLYLH 645 S +I+ + +F+ I + E+MD GSL D+ +++ E L + V++GL YL Sbjct: 220 DSSYIIGFYGAFFVENRISICTEFMDGGSL-DVYRKIP---EHVLGRIAVAVVKGLTYLW 275 Query: 646 HERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISGSS 825 + ++HRD+KPSN+LVN G+VK+ DFGVS L +SI + T+VGT YMAPERISG Sbjct: 276 SLK-ILHRDVKPSNMLVNTGGQVKLCDFGVSTQLVNSIAK--TYVGTNAYMAPERISGEQ 332 Query: 826 YDYKSDVWSLGLVILECAIGRFPYTP-PEGEGWLSFYELLEAIVDQPPPSAPADQFSPEF 1002 Y SDVWSLG+ +E A+GRFPY + +G L +LL+ IVD+ P P +FS F Sbjct: 333 YGIHSDVWSLGISFMELALGRFPYPQIQKNQGSLMPLQLLQCIVDEDSPVLPLGEFSEPF 392 Query: 1003 CSFISSCIQKDPAERKSASELLNHAFIKKFED 1098 FI+ C++K P ER + EL+ H FI +F D Sbjct: 393 VHFITQCMRKQPKERPAPEELMGHPFIVQFND 424
>O09110:MP2K3_MOUSE Dual specificity mitogen-activated protein kinase kinase 3 - Mus| musculus (Mouse) Length = 347 Score = 194 bits (494), Expect = 6e-49 Identities = 108/291 (37%), Positives = 167/291 (57%), Gaps = 8/291 (2%) Frame = +1 Query: 286 QLSMDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQIVQELKINQAT 465 ++ DDL I +G+G+ GVV+ VRH GT A+K I+ + +K+++ +L IN T Sbjct: 58 EVEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNTQEQKRLLMDLDINMRT 117 Query: 466 QSP-HIVLCHQSFYHNGVIYLVLEYMDRGS---LADIIKQVKTILEPYLAVLCKQVLEGL 633 + V + + + G +++ +E MD ++++ I E L + ++ L Sbjct: 118 VDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLEKNMKIPEDILGEIAVSIVRAL 177 Query: 634 LYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERI 813 +LH + VIHRD+KPSN+L+N +G VK+ DFG+S L S+ + G YMAPERI Sbjct: 178 EHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVA-KTMDAGCKPYMAPERI 236 Query: 814 SGS----SYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAPA 981 + Y+ KSDVWSLG+ ++E AI RFPY E W + ++ L+ +V++P P PA Sbjct: 237 NPELNQKGYNVKSDVWSLGITMIEMAILRFPY-----ESWGTPFQQLKQVVEEPSPQLPA 291 Query: 982 DQFSPEFCSFISSCIQKDPAERKSASELLNHAFIKKFEDKDLDLRILVESL 1134 DQFSPEF F S C++K+PAER S EL+ H F + K D+ V+ + Sbjct: 292 DQFSPEFVDFTSQCLRKNPAERMSYLELMEHPFFTLHKTKKTDIAAFVKEI 342
>P46734:MP2K3_HUMAN Dual specificity mitogen-activated protein kinase kinase 3 - Homo| sapiens (Human) Length = 347 Score = 194 bits (493), Expect = 8e-49 Identities = 110/292 (37%), Positives = 169/292 (57%), Gaps = 9/292 (3%) Frame = +1 Query: 286 QLSMDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQIVQELKINQAT 465 ++ DDL I +G+G+ GVV+ VRH GT A+K I+ + +K+++ +L IN T Sbjct: 58 EVEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLLMDLDINMRT 117 Query: 466 QSP-HIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQV----KTILEPYLAVLCKQVLEG 630 + V + + + G +++ +E MD SL ++V TI E L + ++ Sbjct: 118 VDCFYTVTFYGALFREGDVWICMELMDT-SLDKFYRKVLDKNMTIPEDILGEIAVSIVRA 176 Query: 631 LLYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPER 810 L +LH + VIHRD+KPSN+L+N +G VK+ DFG+S L S+ + G YMAPER Sbjct: 177 LEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVA-KTMDAGCKPYMAPER 235 Query: 811 ISGS----SYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAP 978 I+ Y+ KSDVWSLG+ ++E AI RFPY E W + ++ L+ +V++P P P Sbjct: 236 INPELNQKGYNVKSDVWSLGITMIEMAILRFPY-----ESWGTPFQQLKQVVEEPSPQLP 290 Query: 979 ADQFSPEFCSFISSCIQKDPAERKSASELLNHAFIKKFEDKDLDLRILVESL 1134 AD+FSPEF F + C++K+PAER S EL+ H F + K D+ V+ + Sbjct: 291 ADRFSPEFVDFTAQCLRKNPAERMSYLELMEHPFFTLHKTKKTDIAAFVKEI 342
>P10506:BYR1_SCHPO Protein kinase byr1 - Schizosaccharomyces pombe (Fission yeast)| Length = 340 Score = 192 bits (488), Expect = 3e-48 Identities = 102/259 (39%), Positives = 159/259 (61%) Frame = +1 Query: 289 LSMDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQIVQELKINQATQ 468 L LE+++ +G+G+GG V LV+H+ + F A K + + ++KQI++EL + + Sbjct: 61 LDNSSLEVVRHLGEGNGGAVSLVKHRNI--FMARKTVYVGSDSKLQKQILRELGVLHHCR 118 Query: 469 SPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLYLHH 648 SP+IV + +F + I L +EYMD GSL I+++ I L + +++GL+YL++ Sbjct: 119 SPYIVGFYGAFQYKNNISLCMEYMDCGSLDAILREGGPIPLDILGKIINSMVKGLIYLYN 178 Query: 649 ERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISGSSY 828 H+IHRD+KPSN++VN +GE+K+ DFGVS L +S+ Q TFVGT YM+PERI G Y Sbjct: 179 VLHIIHRDLKPSNVVVNSRGEIKLCDFGVSGELVNSVAQ--TFVGTSTYMSPERIRGGKY 236 Query: 829 DYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAPADQFSPEFCS 1008 KSD+WSLG+ I+E A P++ + + +LL IV + PP P+ F + Sbjct: 237 TVKSDIWSLGISIIELATQELPWSFSNIDDSIGILDLLHCIVQEEPPRLPS-SFPEDLRL 295 Query: 1009 FISSCIQKDPAERKSASEL 1065 F+ +C+ KDP R S +L Sbjct: 296 FVDACLHKDPTLRASPQQL 314
>Q99078:FUZ7_USTMA Dual specificity protein kinase FUZ7 - Ustilago maydis (Smut fungus)| Length = 435 Score = 191 bits (486), Expect = 5e-48 Identities = 122/361 (33%), Positives = 182/361 (50%), Gaps = 51/361 (14%) Frame = +1 Query: 208 NQRGLQLISEENGDEHQSTKMKVEDVQLSMDDLEMIQVIGKGSGGVVQLVRHKWVGTFYA 387 N+ QL + E G E++ + L +DL+ + +G G+GG V V H+ GT A Sbjct: 85 NKLTQQLANLELGVEYK--------LDLKNEDLKTLSELGAGNGGTVTKVLHEKSGTVMA 136 Query: 388 LKGIQMNIQESVRKQIVQELKINQATQSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADII 567 K + ++ + SVRKQI++EL+I SP+IV + ++ + I + +E+M + SL I Sbjct: 137 KKVVFIDAKPSVRKQILRELQILHECNSPYIVSFYGAYLNEPHICMCMEFMQKDSLDGIY 196 Query: 568 KQVKTILEPYLAVLCKQVLEGLLYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVL 747 K+ I + V GL YL+ +IHRD+KPSN+LVN G++KI DFGVS L Sbjct: 197 KKYGPISPEICGKIAVAVSHGLTYLYDVHRIIHRDVKPSNILVNGAGQIKICDFGVSGEL 256 Query: 748 ASSIGQRDTFVGTYNYMAPERISGSSYDYKSDVWSLGLVILECAIGRFP----------- 894 +SI DTFVGT YM+PERI G Y KSDVWSLG+ I+E A+GRFP Sbjct: 257 INSIA--DTFVGTSTYMSPERIQGDQYSVKSDVWSLGVSIIELALGRFPFAENEEDDDSD 314 Query: 895 ----YTPPEGEGWL------------------------------------SFYELLEAIV 954 YT + G L S +LL+ IV Sbjct: 315 ADNNYTNEDLAGTLSPTKPAPMISLGQNEKQRRRKSKPAGVSLEGSSHQMSILDLLQHIV 374 Query: 955 DQPPPSAPADQFSPEFCSFISSCIQKDPAERKSASELLNHAFIKKFEDKDLDLRILVESL 1134 ++PPP P +F F++ C+ KDPA+R + +L H ++ + +DL+ + + Sbjct: 375 NEPPPKLPEGRFPKHMEEFVNLCLLKDPAKRPTPKDLTKHQYVIDADAAKVDLQAWADGM 434 Query: 1135 E 1137 + Sbjct: 435 K 435
>Q9Y884:SKH1_SCHPO MAP kinase kinase skh1/pek1 - Schizosaccharomyces pombe (Fission| yeast) Length = 363 Score = 189 bits (481), Expect = 2e-47 Identities = 112/273 (41%), Positives = 162/273 (59%), Gaps = 9/273 (3%) Frame = +1 Query: 322 IGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQIVQELKINQATQSPHIVLCHQSF 501 +G+G G V+ R + +A+K + +++KQ+++ELKIN++ SP+IV + + Sbjct: 85 LGEGVSGSVRKCRIRGTQMIFAMKTVLAAPNTALQKQLLRELKINRSCTSPYIVKYYGAC 144 Query: 502 YHNGVIYL--VLEYMDRGSLADIIKQVKT----ILEPYLAVLCKQVLEGLLYLHHERHVI 663 Y+N L +EY GSL I K+V++ E L + VL GL YLH +R +I Sbjct: 145 YNNAECQLNIAMEYCGAGSLDAIYKRVRSQGGRTGERPLGKIAFGVLSGLSYLH-DRKII 203 Query: 664 HRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISGSSYDYKSD 843 HRDIKPSN+L+ KG+VK+ DFGVS L +S+ TF GT YMAPERISG SY SD Sbjct: 204 HRDIKPSNILLTSKGQVKLCDFGVSGELVNSLA--GTFTGTSYYMAPERISGGSYTISSD 261 Query: 844 VWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAPAD---QFSPEFCSFI 1014 +WSLGL ++E A+ RFP+ PPEG ELL I++ PPP P + ++S F F+ Sbjct: 262 IWSLGLTLMEVALNRFPF-PPEGSPPPMPIELLSYIINMPPPLLPQEPGIKWSKSFQHFL 320 Query: 1015 SSCIQKDPAERKSASELLNHAFIKKFEDKDLDL 1113 C+ KD R ++L H ++K FE +D+ Sbjct: 321 CVCLDKDKTRRPGPQKMLTHPWVKAFERIHVDM 353
>P52564:MP2K6_HUMAN Dual specificity mitogen-activated protein kinase kinase 6 - Homo| sapiens (Human) Length = 334 Score = 187 bits (476), Expect = 7e-47 Identities = 107/293 (36%), Positives = 168/293 (57%), Gaps = 9/293 (3%) Frame = +1 Query: 277 EDVQLSMDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQIVQELKIN 456 ++ ++ DDLE I +G+G+ GVV+ +RH G A+K I+ + +K+++ +L I+ Sbjct: 44 QNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDIS 103 Query: 457 QAT-QSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQV----KTILEPYLAVLCKQV 621 T P V + + + G +++ +E MD SL KQV +TI E L + + Sbjct: 104 MRTVDCPFTVTFYGALFREGDVWICMELMDT-SLDKFYKQVIDKGQTIPEDILGKIAVSI 162 Query: 622 LEGLLYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMA 801 ++ L +LH + VIHRD+KPSN+L+N G+VK+ DFG+S L S+ + G YMA Sbjct: 163 VKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVA-KTIDAGCKPYMA 221 Query: 802 PERI----SGSSYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPP 969 PERI + Y KSD+WSLG+ ++E AI RFPY + W + ++ L+ +V++P P Sbjct: 222 PERINPELNQKGYSVKSDIWSLGITMIELAILRFPY-----DSWGTPFQQLKQVVEEPSP 276 Query: 970 SAPADQFSPEFCSFISSCIQKDPAERKSASELLNHAFIKKFEDKDLDLRILVE 1128 PAD+FS EF F S C++K+ ER + EL+ H F E K D+ V+ Sbjct: 277 QLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKGTDVASFVK 329
>Q5E9X2:MP2K6_BOVIN Dual specificity mitogen-activated protein kinase kinase 6 - Bos| taurus (Bovine) Length = 334 Score = 186 bits (471), Expect = 3e-46 Identities = 107/295 (36%), Positives = 169/295 (57%), Gaps = 9/295 (3%) Frame = +1 Query: 277 EDVQLSMDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQIVQELKIN 456 ++ ++ DDLE I +G+G+ GVV+ +RH A+K I+ + +K+++ +L I+ Sbjct: 44 QNFEVKADDLEPIVELGRGAYGVVEKMRHVPSEQIMAVKRIRATVNSQEQKRLLMDLDIS 103 Query: 457 QAT-QSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQV----KTILEPYLAVLCKQV 621 T P V + + + G +++ +E MD SL KQV +TI E L + + Sbjct: 104 MRTVDCPFTVTFYGALFREGDVWICMELMDT-SLDKFYKQVIDKGQTIPEDILGKIAVSI 162 Query: 622 LEGLLYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMA 801 ++ L +LH + VIHRD+KPSN+L+N G+VK+ DFG+S L S+ + G YMA Sbjct: 163 VKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVA-KTIDAGCKPYMA 221 Query: 802 PERI----SGSSYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPP 969 PERI + Y KSD+WSLG+ ++E AI RFPY + W + ++ L+ +V++P P Sbjct: 222 PERINPELNQKGYSVKSDIWSLGITMIELAILRFPY-----DSWGTPFQQLKQVVEEPSP 276 Query: 970 SAPADQFSPEFCSFISSCIQKDPAERKSASELLNHAFIKKFEDKDLDLRILVESL 1134 PAD+FS EF F S C++K+ ER + EL+ H F E K D+ V+S+ Sbjct: 277 QLPADKFSEEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKATDVASFVKSI 331
>P70236:MP2K6_MOUSE Dual specificity mitogen-activated protein kinase kinase 6 - Mus| musculus (Mouse) Length = 334 Score = 185 bits (469), Expect = 5e-46 Identities = 105/293 (35%), Positives = 168/293 (57%), Gaps = 9/293 (3%) Frame = +1 Query: 277 EDVQLSMDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQIVQELKIN 456 ++ ++ DDLE I +G+G+ GVV+ +RH G A+K I+ + +K+++ +L ++ Sbjct: 44 QNFEVKADDLEPIVELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDVS 103 Query: 457 QAT-QSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQV----KTILEPYLAVLCKQV 621 T P V + + + G +++ +E MD SL KQV +TI E L + + Sbjct: 104 MRTVDCPFTVTFYGALFREGDVWICMELMDT-SLDKFYKQVIDKGQTIPEDILGKIAVSI 162 Query: 622 LEGLLYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMA 801 ++ L +LH + VIHRD+KPSN+L+N G+VK+ DFG+S L S+ + G YMA Sbjct: 163 VKALEHLHSKLSVIHRDVKPSNVLINTLGQVKMCDFGISGYLVDSVA-KTIDAGCKPYMA 221 Query: 802 PERI----SGSSYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPP 969 PERI + Y KSD+WSLG+ ++E AI RFPY + W + ++ L+ +V++P P Sbjct: 222 PERINPELNQKGYSVKSDIWSLGITMIELAILRFPY-----DSWGTPFQQLKQVVEEPSP 276 Query: 970 SAPADQFSPEFCSFISSCIQKDPAERKSASELLNHAFIKKFEDKDLDLRILVE 1128 PAD+FS +F F S C++K+ ER + EL+ H F E K D+ V+ Sbjct: 277 QLPADKFSADFVDFTSQCLKKNSKERPTYPELMQHPFFTVHESKAADVASFVK 329
>P32490:MKK1_YEAST MAP kinase kinase MKK1/SSP32 - Saccharomyces cerevisiae (Baker's| yeast) Length = 508 Score = 182 bits (461), Expect = 4e-45 Identities = 120/308 (38%), Positives = 171/308 (55%), Gaps = 11/308 (3%) Frame = +1 Query: 235 EENGDEHQSTKMKVEDVQLSMDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQ-MNI 411 +ENG ++ + K D +E + ++G+G+GG V + K +ALK I +N Sbjct: 208 DENGWKYANLK----------DRIETLGILGEGAGGSVSKCKLKNGSKIFALKVINTLNT 257 Query: 412 QESVRKQIVQELKINQATQSPHIVLCHQSFY--HNGVIYLVLEYMDRGSLADIIKQVKT- 582 +KQI +EL+ N++ QS +IV + F N IY+ +EYM SL I K + Sbjct: 258 DPEYQKQIFRELQFNRSFQSEYIVRYYGMFTDDENSSIYIAMEYMGGRSLDAIYKNLLER 317 Query: 583 ---ILEPYLAVLCKQVLEGLLYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLAS 753 I E L + + VL GL YLH E+ VIHRDIKP N+L+N G+VK+ DFGVS + Sbjct: 318 GGRISEKVLGKIAEAVLRGLSYLH-EKKVIHRDIKPQNILLNENGQVKLCDFGVSGEAVN 376 Query: 754 SIGQRDTFVGTYNYMAPERISGSSYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFY 933 S+ TF GT YMAPERI G Y SDVWSLGL ILE A G+FP + + ++ + Sbjct: 377 SLAT--TFTGTSFYMAPERIQGQPYSVTSDVWSLGLTILEVANGKFPCSSEKMAANIAPF 434 Query: 934 ELLEAIVDQPPPSAPADQ----FSPEFCSFISSCIQKDPAERKSASELLNHAFIKKFEDK 1101 ELL I+ P + +SP F SFI C++KD ER S +++NH +IK K Sbjct: 435 ELLMWILTFTPELKDEPESNIIWSPSFKSFIDYCLKKDSRERPSPRQMINHPWIKGQMKK 494 Query: 1102 DLDLRILV 1125 ++++ V Sbjct: 495 NVNMEKFV 502
>P32491:MKK2_YEAST MAP kinase kinase MKK2/SSP33 - Saccharomyces cerevisiae (Baker's| yeast) Length = 506 Score = 172 bits (435), Expect = 4e-42 Identities = 110/273 (40%), Positives = 155/273 (56%), Gaps = 11/273 (4%) Frame = +1 Query: 298 DDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQ-MNIQESVRKQIVQELKINQATQSP 474 D++ + ++G+G+GG V R K +ALK I MN +KQI +EL+ N++ +S Sbjct: 212 DEITTLGILGEGAGGSVAKCRLKNGKKVFALKTINTMNTDPEYQKQIFRELQFNKSFKSD 271 Query: 475 HIVLCHQSFY--HNGVIYLVLEYMDRGSLA----DIIKQVKTILEPYLAVLCKQVLEGLL 636 +IV + F + IY+ +EYM SL +++K+ I E + + + VL GL Sbjct: 272 YIVQYYGMFTDEQSSSIYIAMEYMGGKSLEATYKNLLKRGGRISERVIGKIAESVLRGLS 331 Query: 637 YLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERIS 816 YLH ER VIHRDIKP N+L+N KGE+K+ DFGVS +S+ TF GT YMAPERI Sbjct: 332 YLH-ERKVIHRDIKPQNILLNEKGEIKLCDFGVSGEAVNSLAM--TFTGTSFYMAPERIQ 388 Query: 817 GSSYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAPADQ--- 987 G Y DVWSLGL +LE A GRFP+ + ++ ELL I+ P + Sbjct: 389 GQPYSVTCDVWSLGLTLLEVAGGRFPFESDKITQNVAPIELLTMILTFSPQLKDEPELDI 448 Query: 988 -FSPEFCSFISSCIQKDPAERKSASELLNHAFI 1083 +S F SFI C++KD ER S ++L H +I Sbjct: 449 SWSKTFRSFIDYCLKKDARERPSPRQMLKHPWI 481
>A4K2M3:STK4_PAPAN Serine/threonine-protein kinase 4 - Papio anubis (Olive baboon)| Length = 487 Score = 171 bits (433), Expect = 7e-42 Identities = 98/309 (31%), Positives = 175/309 (56%), Gaps = 3/309 (0%) Frame = +1 Query: 220 LQLISEENGDEHQSTKMKVEDVQLSMDDL-EMIQVIGKGSGGVVQLVRHKWVGTFYALKG 396 ++ + N Q K+ + + +++ ++++ +G+GS G V HK G A+K Sbjct: 1 METVQLRNPPRRQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQ 60 Query: 397 IQMNIQESVRKQIVQELKINQATQSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIK-Q 573 + + ES ++I++E+ I Q SPH+V + S++ N +++V+EY GS++DII+ + Sbjct: 61 VPV---ESDLQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLR 117 Query: 574 VKTILEPYLAVLCKQVLEGLLYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLAS 753 KT+ E +A + + L+GL YLH R IHRDIK N+L+N +G+ K+ DFGV+ L Sbjct: 118 NKTLTEDEIATILQSTLKGLEYLHFMRK-IHRDIKAGNILLNTEGQAKLADFGVAGQLTD 176 Query: 754 SIGQRDTFVGTYNYMAPERISGSSYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFY 933 ++ +R+T +GT +MAPE I Y+ +D+WSLG+ +E A G+ PY + Sbjct: 177 TMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYAD------IHPM 230 Query: 934 ELLEAIVDQPPPS-APADQFSPEFCSFISSCIQKDPAERKSASELLNHAFIKKFEDKDLD 1110 + I PPP+ + +S F F+ C+ K P +R +A++LL H F+K + + Sbjct: 231 RAIFMIPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFVKSAKGVSIL 290 Query: 1111 LRILVESLE 1137 ++ E+++ Sbjct: 291 RDLINEAMD 299
>Q13188:STK3_HUMAN Serine/threonine-protein kinase 3 - Homo sapiens (Human)| Length = 491 Score = 171 bits (433), Expect = 7e-42 Identities = 97/279 (34%), Positives = 165/279 (59%), Gaps = 2/279 (0%) Frame = +1 Query: 307 EMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQIVQELKINQATQSPHIVL 486 ++++ +G+GS G V HK G A+K + + ES ++I++E+ I Q SP++V Sbjct: 28 DVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPV---ESDLQEIIKEISIMQQCDSPYVVK 84 Query: 487 CHQSFYHNGVIYLVLEYMDRGSLADIIK-QVKTILEPYLAVLCKQVLEGLLYLHHERHVI 663 + S++ N +++V+EY GS++DII+ + KT++E +A + K L+GL YLH R I Sbjct: 85 YYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHFMRK-I 143 Query: 664 HRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISGSSYDYKSD 843 HRDIK N+L+N +G K+ DFGV+ L ++ +R+T +GT +MAPE I Y+ +D Sbjct: 144 HRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVAD 203 Query: 844 VWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPS-APADQFSPEFCSFISS 1020 +WSLG+ +E A G+ PY + + I PPP+ + +S +F F+ Sbjct: 204 IWSLGITSIEMAEGKPPYAD------IHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKK 257 Query: 1021 CIQKDPAERKSASELLNHAFIKKFEDKDLDLRILVESLE 1137 C+ K+P +R +A++LL H FIK + + ++ E++E Sbjct: 258 CLVKNPEQRATATQLLQHPFIKNAKPVSILRDLITEAME 296
>Q8T0S6:HIPPO_DROME Serine/threonine-protein kinase hippo - Drosophila melanogaster| (Fruit fly) Length = 669 Score = 171 bits (433), Expect = 7e-42 Identities = 99/277 (35%), Positives = 164/277 (59%), Gaps = 2/277 (0%) Frame = +1 Query: 307 EMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQIVQELKINQATQSPHIVL 486 +++ +G+GS G V HK + A+K + + ES +I++E+ I Q SP++V Sbjct: 43 DIMYKLGEGSYGSVYKAVHKESSSIVAIKLVPV---ESDLHEIIKEISIMQQCDSPYVVR 99 Query: 487 CHQSFYHNGVIYLVLEYMDRGSLADIIK-QVKTILEPYLAVLCKQVLEGLLYLHHERHVI 663 + S++ +++ +EY GS++DI++ + KT+ E +A + L+GL+YLH R I Sbjct: 100 YYGSYFKQYDLWICMEYCGAGSVSDIMRLRKKTLTEDEIATILSDTLQGLVYLHLRRK-I 158 Query: 664 HRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISGSSYDYKSD 843 HRDIK +N+L+N +G K+ DFGV+ L ++ +R+T +GT +MAPE I YD +D Sbjct: 159 HRDIKAANILLNTEGYAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIEEIGYDCVAD 218 Query: 844 VWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPS-APADQFSPEFCSFISS 1020 +WSLG+ LE A G+ PY G + + I +PPPS D++S EF F+S Sbjct: 219 IWSLGITALEMAEGKPPY------GEIHPMRAIFMIPQKPPPSFREPDRWSTEFIDFVSK 272 Query: 1021 CIQKDPAERKSASELLNHAFIKKFEDKDLDLRILVES 1131 C+ K+P +R +A+ELL H FI+ + + + +L E+ Sbjct: 273 CLVKEPDDRATATELLEHEFIRNAKHRSILKPMLEET 309
>Q9JI11:STK4_MOUSE Serine/threonine-protein kinase 4 - Mus musculus (Mouse)| Length = 487 Score = 170 bits (431), Expect = 1e-41 Identities = 98/309 (31%), Positives = 174/309 (56%), Gaps = 3/309 (0%) Frame = +1 Query: 220 LQLISEENGDEHQSTKMKVEDVQLSMDDL-EMIQVIGKGSGGVVQLVRHKWVGTFYALKG 396 ++ + N Q K+ + + +++ ++++ +G+GS G V HK G A+K Sbjct: 1 METVQLRNPPRRQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQ 60 Query: 397 IQMNIQESVRKQIVQELKINQATQSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIK-Q 573 + + ES ++I++E+ I Q SPH+V + S++ N +++V+EY GS++DII+ + Sbjct: 61 VPV---ESDLQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLR 117 Query: 574 VKTILEPYLAVLCKQVLEGLLYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLAS 753 KT+ E +A + + L+GL YLH R IHRDIK N+L+N +G K+ DFGV+ L Sbjct: 118 NKTLTEDEIATILQSTLKGLEYLHFMRK-IHRDIKAGNILLNTEGHAKLADFGVAGQLTD 176 Query: 754 SIGQRDTFVGTYNYMAPERISGSSYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFY 933 ++ +R+T +GT +MAPE I Y+ +D+WSLG+ +E A G+ PY + Sbjct: 177 TMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYAD------IHPM 230 Query: 934 ELLEAIVDQPPPS-APADQFSPEFCSFISSCIQKDPAERKSASELLNHAFIKKFEDKDLD 1110 + I PPP+ + +S F F+ C+ K P +R +A++LL H F+K + + Sbjct: 231 RAIFMIPTNPPPTFRKPELWSDNFMDFVKQCLVKSPEQRATATQLLQHPFVKSAKGVSIL 290 Query: 1111 LRILVESLE 1137 ++ E+++ Sbjct: 291 RDLINEAMD 299
>A4K2T0:STK4_MACMU Serine/threonine-protein kinase 4 - Macaca mulatta (Rhesus macaque)| Length = 487 Score = 170 bits (431), Expect = 1e-41 Identities = 98/309 (31%), Positives = 174/309 (56%), Gaps = 3/309 (0%) Frame = +1 Query: 220 LQLISEENGDEHQSTKMKVEDVQLSMDDL-EMIQVIGKGSGGVVQLVRHKWVGTFYALKG 396 ++ + N Q K+ + + +++ ++++ +G+GS G V HK G A+K Sbjct: 1 METVQLRNPPRRQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQ 60 Query: 397 IQMNIQESVRKQIVQELKINQATQSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIK-Q 573 + + ES ++I++E+ I Q SPH+V + S++ N +++V+EY GS++DII+ + Sbjct: 61 VPV---ESDLQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLR 117 Query: 574 VKTILEPYLAVLCKQVLEGLLYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLAS 753 KT+ E +A + + L+GL YLH R IHRDIK N+L+N +G K+ DFGV+ L Sbjct: 118 NKTLTEDEIATILQSTLKGLEYLHFMRK-IHRDIKAGNILLNTEGHAKLADFGVAGQLTD 176 Query: 754 SIGQRDTFVGTYNYMAPERISGSSYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFY 933 ++ +R+T +GT +MAPE I Y+ +D+WSLG+ +E A G+ PY + Sbjct: 177 TMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYAD------IHPM 230 Query: 934 ELLEAIVDQPPPS-APADQFSPEFCSFISSCIQKDPAERKSASELLNHAFIKKFEDKDLD 1110 + I PPP+ + +S F F+ C+ K P +R +A++LL H F+K + + Sbjct: 231 RAIFMIPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFVKSAKGVSIL 290 Query: 1111 LRILVESLE 1137 ++ E+++ Sbjct: 291 RDLINEAMD 299
>A4K2Y1:STK4_CERAE Serine/threonine-protein kinase 4 - Cercopithecus aethiops (Green| monkey) (Grivet) Length = 487 Score = 170 bits (431), Expect = 1e-41 Identities = 98/309 (31%), Positives = 174/309 (56%), Gaps = 3/309 (0%) Frame = +1 Query: 220 LQLISEENGDEHQSTKMKVEDVQLSMDDL-EMIQVIGKGSGGVVQLVRHKWVGTFYALKG 396 ++ + N Q K+ + + +++ ++++ +G+GS G V HK G A+K Sbjct: 1 METVQLRNPPRRQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQ 60 Query: 397 IQMNIQESVRKQIVQELKINQATQSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIK-Q 573 + + ES ++I++E+ I Q SPH+V + S++ N +++V+EY GS++DII+ + Sbjct: 61 VPV---ESDLQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLR 117 Query: 574 VKTILEPYLAVLCKQVLEGLLYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLAS 753 KT+ E +A + + L+GL YLH R IHRDIK N+L+N +G K+ DFGV+ L Sbjct: 118 NKTLTEDEIATILQSTLKGLEYLHFMRK-IHRDIKAGNILLNTEGHAKLADFGVAGQLTD 176 Query: 754 SIGQRDTFVGTYNYMAPERISGSSYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFY 933 ++ +R+T +GT +MAPE I Y+ +D+WSLG+ +E A G+ PY + Sbjct: 177 TMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYAD------IHPM 230 Query: 934 ELLEAIVDQPPPS-APADQFSPEFCSFISSCIQKDPAERKSASELLNHAFIKKFEDKDLD 1110 + I PPP+ + +S F F+ C+ K P +R +A++LL H F+K + + Sbjct: 231 RAIFMIPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFVKSAKGVSIL 290 Query: 1111 LRILVESLE 1137 ++ E+++ Sbjct: 291 RDLINEAMD 299
>Q5E9L6:STK4_BOVIN Serine/threonine-protein kinase 4 - Bos taurus (Bovine)| Length = 487 Score = 170 bits (431), Expect = 1e-41 Identities = 98/309 (31%), Positives = 174/309 (56%), Gaps = 3/309 (0%) Frame = +1 Query: 220 LQLISEENGDEHQSTKMKVEDVQLSMDDL-EMIQVIGKGSGGVVQLVRHKWVGTFYALKG 396 ++ + N Q K+ + + +++ ++++ +G+GS G V HK G A+K Sbjct: 1 METVQLRNPPRRQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQ 60 Query: 397 IQMNIQESVRKQIVQELKINQATQSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIK-Q 573 + + ES ++I++E+ I Q SPH+V + S++ N +++V+EY GS++DII+ + Sbjct: 61 VPV---ESDLQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLR 117 Query: 574 VKTILEPYLAVLCKQVLEGLLYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLAS 753 KT+ E +A + + L+GL YLH R IHRDIK N+L+N +G K+ DFGV+ L Sbjct: 118 NKTLTEDEIATILQSTLKGLEYLHFMRK-IHRDIKAGNILLNTEGHAKLADFGVAGQLTD 176 Query: 754 SIGQRDTFVGTYNYMAPERISGSSYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFY 933 ++ +R+T +GT +MAPE I Y+ +D+WSLG+ +E A G+ PY + Sbjct: 177 TMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYAD------IHPM 230 Query: 934 ELLEAIVDQPPPS-APADQFSPEFCSFISSCIQKDPAERKSASELLNHAFIKKFEDKDLD 1110 + I PPP+ + +S F F+ C+ K P +R +A++LL H F+K + + Sbjct: 231 RAIFMIPTNPPPTFRKPELWSDSFMDFVKQCLVKSPEQRATATQLLQHPFVKSAKGVSIL 290 Query: 1111 LRILVESLE 1137 ++ E+++ Sbjct: 291 RDLINEAMD 299
>A4K2P5:STK4_COLGU Serine/threonine-protein kinase 4 - Colobus guereza (Black-and-white| colobus monkey) Length = 487 Score = 170 bits (430), Expect = 2e-41 Identities = 98/309 (31%), Positives = 174/309 (56%), Gaps = 3/309 (0%) Frame = +1 Query: 220 LQLISEENGDEHQSTKMKVEDVQLSMDDL-EMIQVIGKGSGGVVQLVRHKWVGTFYALKG 396 ++ + N Q K+ + + +++ ++++ +G+GS G V HK G A+K Sbjct: 1 METVQLRNPPRRQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQ 60 Query: 397 IQMNIQESVRKQIVQELKINQATQSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIK-Q 573 + + ES ++I++E+ I Q SPH+V + S++ N +++V+EY GS++DII+ + Sbjct: 61 VPV---ESDLQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLR 117 Query: 574 VKTILEPYLAVLCKQVLEGLLYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLAS 753 KT+ E +A + + L+GL YLH R IHRDIK N+L+N +G K+ DFGV+ L Sbjct: 118 NKTLTEDEIATVLQSTLKGLEYLHFMRK-IHRDIKAGNILLNTEGHAKLADFGVAGQLTD 176 Query: 754 SIGQRDTFVGTYNYMAPERISGSSYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFY 933 ++ +R+T +GT +MAPE I Y+ +D+WSLG+ +E A G+ PY + Sbjct: 177 TMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYAD------IHPM 230 Query: 934 ELLEAIVDQPPPS-APADQFSPEFCSFISSCIQKDPAERKSASELLNHAFIKKFEDKDLD 1110 + I PPP+ + +S F F+ C+ K P +R +A++LL H F+K + + Sbjct: 231 RAIFMIPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFVKSAKGVSIL 290 Query: 1111 LRILVESLE 1137 ++ E+++ Sbjct: 291 RDLINEAMD 299
>A4K2Q5:STK4_OTOGA Serine/threonine-protein kinase 4 - Otolemur garnettii (Small-eared| galago) (Garnett's greater bushbaby) Length = 487 Score = 169 bits (429), Expect = 2e-41 Identities = 98/309 (31%), Positives = 174/309 (56%), Gaps = 3/309 (0%) Frame = +1 Query: 220 LQLISEENGDEHQSTKMKVEDVQLSMDDL-EMIQVIGKGSGGVVQLVRHKWVGTFYALKG 396 ++ + N Q K+ + + +++ ++++ +G+GS G V HK G A+K Sbjct: 1 METVQLRNPPRRQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQ 60 Query: 397 IQMNIQESVRKQIVQELKINQATQSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIK-Q 573 + + ES ++I++E+ I Q SPH+V + S++ N +++V+EY GS++DII+ + Sbjct: 61 VPV---ESDLQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLR 117 Query: 574 VKTILEPYLAVLCKQVLEGLLYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLAS 753 KT+ E +A + + L+GL YLH R IHRDIK N+L+N +G K+ DFGV+ L Sbjct: 118 NKTLTEDEIATILQSTLKGLEYLHFMRK-IHRDIKAGNILLNTEGHAKLADFGVAGQLTD 176 Query: 754 SIGQRDTFVGTYNYMAPERISGSSYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFY 933 ++ +R+T +GT +MAPE I Y+ +D+WSLG+ +E A G+ PY + Sbjct: 177 TMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYAD------IHPM 230 Query: 934 ELLEAIVDQPPPS-APADQFSPEFCSFISSCIQKDPAERKSASELLNHAFIKKFEDKDLD 1110 + I PPP+ + +S F F+ C+ K P +R +A++LL H F+K + + Sbjct: 231 RAIFMIPTNPPPTFRKPELWSDNFTDFVRQCLVKSPDQRATATQLLQHPFVKSAKGVSIL 290 Query: 1111 LRILVESLE 1137 ++ E+++ Sbjct: 291 RDLINEAMD 299
>A4K2S1:STK4_LEMCA Serine/threonine-protein kinase 4 - Lemur catta (Ring-tailed lemur)| Length = 487 Score = 169 bits (429), Expect = 2e-41 Identities = 98/309 (31%), Positives = 174/309 (56%), Gaps = 3/309 (0%) Frame = +1 Query: 220 LQLISEENGDEHQSTKMKVEDVQLSMDDL-EMIQVIGKGSGGVVQLVRHKWVGTFYALKG 396 ++ + N Q K+ + + +++ ++++ +G+GS G V HK G A+K Sbjct: 1 METVQLRNPPRRQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQ 60 Query: 397 IQMNIQESVRKQIVQELKINQATQSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIK-Q 573 + + ES ++I++E+ I Q SPH+V + S++ N +++V+EY GS++DII+ + Sbjct: 61 VPV---ESDLQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLR 117 Query: 574 VKTILEPYLAVLCKQVLEGLLYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLAS 753 KT+ E +A + + L+GL YLH R IHRDIK N+L+N +G K+ DFGV+ L Sbjct: 118 NKTLTEDEIATILQSTLKGLEYLHFMRK-IHRDIKAGNILLNTEGHAKLADFGVAGQLTD 176 Query: 754 SIGQRDTFVGTYNYMAPERISGSSYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFY 933 ++ +R+T +GT +MAPE I Y+ +D+WSLG+ +E A G+ PY + Sbjct: 177 TMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYAD------IHPM 230 Query: 934 ELLEAIVDQPPPS-APADQFSPEFCSFISSCIQKDPAERKSASELLNHAFIKKFEDKDLD 1110 + I PPP+ + +S F F+ C+ K P +R +A++LL H F+K + + Sbjct: 231 RAIFMIPTNPPPTFRKPELWSDNFMDFVRQCLVKSPDQRATATQLLQHPFVKSAKGVSIL 290 Query: 1111 LRILVESLE 1137 ++ E+++ Sbjct: 291 RDLINEAMD 299
>O54748:STK3_RAT Serine/threonine-protein kinase 3 - Rattus norvegicus (Rat)| Length = 491 Score = 169 bits (429), Expect = 2e-41 Identities = 97/279 (34%), Positives = 162/279 (58%), Gaps = 2/279 (0%) Frame = +1 Query: 307 EMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQIVQELKINQATQSPHIVL 486 ++++ +G+GS G V HK G A+K + + ES ++I++E+ I Q SP++V Sbjct: 28 DVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPV---ESDVQEIIKEISIMQQCDSPYVVK 84 Query: 487 CHQSFYHNGVIYLVLEYMDRGSLADIIK-QVKTILEPYLAVLCKQVLEGLLYLHHERHVI 663 + S++ N +++V+EY GS++DII+ + KT+ E +A + K L+GL YLH R I Sbjct: 85 YYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILKSTLKGLEYLHFMRK-I 143 Query: 664 HRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISGSSYDYKSD 843 HRDIK N+L+N +G K+ DFGV+ L ++ +R+T +GT +MAPE I Y+ +D Sbjct: 144 HRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVAD 203 Query: 844 VWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPS-APADQFSPEFCSFISS 1020 +WSLG+ +E A G+ PY + + I PPP+ + +S +F F+ Sbjct: 204 IWSLGITSIEMAEGKPPYAD------IHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKK 257 Query: 1021 CIQKDPAERKSASELLNHAFIKKFEDKDLDLRILVESLE 1137 C+ K P +R +A++LL H FIK + + ++ E +E Sbjct: 258 CLVKSPEQRATATQLLQHPFIKNAKPVSILRELITEGME 296
>Q9JI10:STK3_MOUSE Serine/threonine-protein kinase 3 - Mus musculus (Mouse)| Length = 497 Score = 169 bits (429), Expect = 2e-41 Identities = 97/279 (34%), Positives = 163/279 (58%), Gaps = 2/279 (0%) Frame = +1 Query: 307 EMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQIVQELKINQATQSPHIVL 486 ++++ +G+GS G V HK G A+K + + ES ++I++E+ I Q SP++V Sbjct: 28 DVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPV---ESDLQEIIKEISIMQQCDSPYVVK 84 Query: 487 CHQSFYHNGVIYLVLEYMDRGSLADIIK-QVKTILEPYLAVLCKQVLEGLLYLHHERHVI 663 + S++ N +++V+EY GS++DII+ + KT+ E +A + K L+GL YLH R I Sbjct: 85 YYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILKSTLKGLEYLHFMRK-I 143 Query: 664 HRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISGSSYDYKSD 843 HRDIK N+L+N +G K+ DFGV+ L ++ +R+T +GT +MAPE I Y+ +D Sbjct: 144 HRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVAD 203 Query: 844 VWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPS-APADQFSPEFCSFISS 1020 +WSLG+ +E A G+ PY + + I PPP+ + +S +F F+ Sbjct: 204 IWSLGITSIEMAEGKPPYAD------IHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKK 257 Query: 1021 CIQKDPAERKSASELLNHAFIKKFEDKDLDLRILVESLE 1137 C+ K P +R +A++LL H FIK + + ++ E++E Sbjct: 258 CLVKSPEQRATATQLLQHPFIKNAKPVSILRDLIAEAME 296
>Q13043:STK4_HUMAN Serine/threonine-protein kinase 4 - Homo sapiens (Human)| Length = 487 Score = 169 bits (428), Expect = 3e-41 Identities = 97/309 (31%), Positives = 174/309 (56%), Gaps = 3/309 (0%) Frame = +1 Query: 220 LQLISEENGDEHQSTKMKVEDVQLSMDDL-EMIQVIGKGSGGVVQLVRHKWVGTFYALKG 396 ++ + N Q K+ + + +++ ++++ +G+GS G V HK G A+K Sbjct: 1 METVQLRNPPRRQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQ 60 Query: 397 IQMNIQESVRKQIVQELKINQATQSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIK-Q 573 + + ES ++I++E+ I Q SPH+V + S++ N +++V+EY GS++DII+ + Sbjct: 61 VPV---ESDLQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLR 117 Query: 574 VKTILEPYLAVLCKQVLEGLLYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLAS 753 KT+ E +A + + L+GL YLH R IHRDIK N+L+N +G K+ DFGV+ L Sbjct: 118 NKTLTEDEIATILQSTLKGLEYLHFMRK-IHRDIKAGNILLNTEGHAKLADFGVAGQLTD 176 Query: 754 SIGQRDTFVGTYNYMAPERISGSSYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFY 933 ++ +R+T +GT +MAPE I Y+ +D+WSLG+ +E A G+ PY + Sbjct: 177 TMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYAD------IHPM 230 Query: 934 ELLEAIVDQPPPS-APADQFSPEFCSFISSCIQKDPAERKSASELLNHAFIKKFEDKDLD 1110 + I PPP+ + +S F F+ C+ K P +R +A++LL H F++ + + Sbjct: 231 RAIFMIPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFVRSAKGVSIL 290 Query: 1111 LRILVESLE 1137 ++ E+++ Sbjct: 291 RDLINEAMD 299
>Q802A6:STK4_SQUAC Serine/threonine-protein kinase 3/4 - Squalus acanthias (Spiny| dogfish) Length = 491 Score = 169 bits (427), Expect = 3e-41 Identities = 95/279 (34%), Positives = 164/279 (58%), Gaps = 2/279 (0%) Frame = +1 Query: 307 EMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQIVQELKINQATQSPHIVL 486 ++++ +G+GS G V HK G A+K + + ES ++I++E+ I Q SPH+V Sbjct: 33 DVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPV---ESDLQEIIKEISIMQQCDSPHVVK 89 Query: 487 CHQSFYHNGVIYLVLEYMDRGSLADIIK-QVKTILEPYLAVLCKQVLEGLLYLHHERHVI 663 + S++ N +++V+EY GS++D+I+ + KT+ E +A + + L+GL YLH R I Sbjct: 90 YYGSYFKNTDLWIVMEYCGAGSVSDLIRIRNKTLTEDEIATILQSTLKGLEYLHFMRK-I 148 Query: 664 HRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISGSSYDYKSD 843 HRDIK N+L+N++G K+ DFGV+ L ++ +R+T +GT +MAPE I Y+ +D Sbjct: 149 HRDIKAGNILLNNEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVAD 208 Query: 844 VWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPS-APADQFSPEFCSFISS 1020 +WSLG+ +E A G+ PY + + I PPP+ + ++ EF F+ Sbjct: 209 IWSLGISAIEMAEGKPPYAD------IHPMRAIFMIPTNPPPTFRKPELWTDEFTDFVKQ 262 Query: 1021 CIQKDPAERKSASELLNHAFIKKFEDKDLDLRILVESLE 1137 C+ K+P +R +A++LL H FIK + + ++ + +E Sbjct: 263 CLVKNPEQRAAATQLLQHPFIKNAKPVSILRDLITDMME 301
>Q9NB31:CST1_CAEEL Serine/threonine-protein kinase cst-1 - Caenorhabditis elegans| Length = 497 Score = 168 bits (425), Expect = 6e-41 Identities = 101/308 (32%), Positives = 174/308 (56%), Gaps = 5/308 (1%) Frame = +1 Query: 232 SEENGDEHQSTKMKVEDVQLSMDDLEMIQVIGK---GSGGVVQLVRHKWVGTFYALKGIQ 402 S N +E S K++ L+ E+ ++GK GS G V H+ G A+K + Sbjct: 8 SRRNSEEGSSDGFKLDSSALNKPPEEVFDIVGKLGEGSYGSVHKAIHRESGHVLAIKKVP 67 Query: 403 MNIQESVRKQIVQELKINQATQSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIK-QVK 579 ++ ++I++E+ I Q +S ++V + S++ + +++V+EY GS++DI++ + K Sbjct: 68 VDTD---LQEIIKEISIMQQCKSKYVVKYYGSYFKHSDLWIVMEYCGAGSISDIMRARRK 124 Query: 580 TILEPYLAVLCKQVLEGLLYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSI 759 + E ++ + + L+GL YLH + IHRDIK N+L+N G K+ DFGV+ L ++ Sbjct: 125 PLSEQEISAVLRDTLKGLQYLHDLKK-IHRDIKAGNILLNTDGIAKLADFGVAGQLTDTM 183 Query: 760 GQRDTFVGTYNYMAPERISGSSYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYEL 939 +R+T +GT +MAPE I YD K+D+WSLG+ +E A GR PY+ + Sbjct: 184 AKRNTVIGTPFWMAPEVIEEIGYDTKADIWSLGITAIEMAEGRPPYSD------IHPMRA 237 Query: 940 LEAIVDQPPPS-APADQFSPEFCSFISSCIQKDPAERKSASELLNHAFIKKFEDKDLDLR 1116 + I +PPP+ +++S EF FI SC+ K P ERK+A L H FIK D+ ++ Sbjct: 238 IFMIPTKPPPTFKKPEEWSSEFNDFIRSCLIKKPEERKTALRLCEHTFIKNAPGCDI-MQ 296 Query: 1117 ILVESLEQ 1140 ++++ ++ Sbjct: 297 LMIQDAQE 304
>Q7ZUQ3:STK3_DANRE Serine/threonine-protein kinase 3 - Danio rerio (Zebrafish)| (Brachydanio rerio) Length = 492 Score = 167 bits (424), Expect = 8e-41 Identities = 102/288 (35%), Positives = 166/288 (57%), Gaps = 10/288 (3%) Frame = +1 Query: 250 EHQSTKMKVEDVQLSMDDL--------EMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQM 405 EH K K++ +LS D L ++++ +G+GS G V HK G A+K + + Sbjct: 2 EHSVPKNKLK--KLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPV 59 Query: 406 NIQESVRKQIVQELKINQATQSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIK-QVKT 582 ES ++I++E+ I Q SP++V + S++ N +++V+EY GS++DII+ + KT Sbjct: 60 ---ESDLQEIIKEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKT 116 Query: 583 ILEPYLAVLCKQVLEGLLYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIG 762 + E +A + K L+GL YLH R IHRDIK N+L+N +G K+ DFGV+ L ++ Sbjct: 117 LTEDEIATVLKSTLKGLEYLHFMRK-IHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMA 175 Query: 763 QRDTFVGTYNYMAPERISGSSYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELL 942 +R+T +GT +MAPE I Y+ +D+WSLG+ +E A G+ PY + + Sbjct: 176 KRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITSIEMAEGKPPYAD------IHPMRAI 229 Query: 943 EAIVDQPPPS-APADQFSPEFCSFISSCIQKDPAERKSASELLNHAFI 1083 I PPP+ + +S +F F+ C+ K+P +R +A++LL H FI Sbjct: 230 FMIPTNPPPTFRKPEHWSDDFTDFVKKCLVKNPEQRATATQLLQHPFI 277
>P45985:MP2K4_HUMAN Dual specificity mitogen-activated protein kinase kinase 4 - Homo| sapiens (Human) Length = 399 Score = 167 bits (424), Expect = 8e-41 Identities = 120/372 (32%), Positives = 191/372 (51%), Gaps = 20/372 (5%) Frame = +1 Query: 70 PSHSKEEAMRGKKPLKELTLSVPAQETPVDKFLTASGTFKDGELRLNQRGLQLISEENGD 249 P H +M+GK+ +L + P ++ TA T L N G+Q E Sbjct: 29 PGHPAVSSMQGKRKALKLNFANPPFKS------TARFT-----LNPNPTGVQNPHIERLR 77 Query: 250 EHQ---STKMKVEDVQ---LSMDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNI 411 H S K+K+ Q + +DL+ + IG+G+ G V + HK G A+K I+ + Sbjct: 78 THSIESSGKLKISPEQHWDFTAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTV 137 Query: 412 QESVRKQIVQELKI-NQATQSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTIL 588 E +KQ++ +L + +++ P+IV + + + G ++ +E M S K V ++L Sbjct: 138 DEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMST-SFDKFYKYVYSVL 196 Query: 589 -----EPYLAVLCKQVLEGLLYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLAS 753 E L + ++ L +L +IHRDIKPSN+L++ G +K+ DFG+S L Sbjct: 197 DDVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVD 256 Query: 754 SIGQ-RDTFVGTYNYMAPERISGSS----YDYKSDVWSLGLVILECAIGRFPYTPPEGEG 918 SI + RD G YMAPERI S+ YD +SDVWSLG+ + E A GRFPY Sbjct: 257 SIAKTRD--AGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPK----- 309 Query: 919 WLSFYELLEAIVDQPPP---SAPADQFSPEFCSFISSCIQKDPAERKSASELLNHAFIKK 1089 W S ++ L +V PP ++ +FSP F +F++ C+ KD ++R ELL H FI Sbjct: 310 WNSVFDQLTQVVKGDPPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFILM 369 Query: 1090 FEDKDLDLRILV 1125 +E++ +++ V Sbjct: 370 YEERAVEVACYV 381
>P06784:STE7_YEAST Serine/threonine-protein kinase STE7 - Saccharomyces cerevisiae| (Baker's yeast) Length = 515 Score = 167 bits (423), Expect = 1e-40 Identities = 111/298 (37%), Positives = 160/298 (53%), Gaps = 24/298 (8%) Frame = +1 Query: 289 LSMDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQES-VRKQIVQELKINQAT 465 + + DL + IG G+ G V H A K I + S + Q+V+EL I + Sbjct: 186 IQLQDLVQLGKIGAGNSGTVVKALHVPDSKIVAKKTIPVEQNNSTIINQLVRELSIVKNV 245 Query: 466 QSPH--IVLCHQSFYH---NGVIYLVLEYMDRGSLADIIKQVKTIL-------------E 591 + PH I+ + ++Y+ N I +++EY D GSL I+ K + E Sbjct: 246 K-PHENIITFYGAYYNQHINNEIIILMEYSDCGSLDKILSVYKRFVQRGTVSSKKTWFNE 304 Query: 592 PYLAVLCKQVLEGLLYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRD 771 ++ + VL GL +L+ + +IHRDIKPSN+L+N KG++K+ DFGVS L +SI D Sbjct: 305 LTISKIAYGVLNGLDHLYRQYKIIHRDIKPSNVLINSKGQIKLCDFGVSKKLINSIA--D 362 Query: 772 TFVGTYNYMAPERISGSSYDYKSDVWSLGLVILECAIGRFPY----TPPEGEGWLSFYEL 939 TFVGT YM+PERI G+ Y K DVWSLGL+I+E G FP P+G +L Sbjct: 363 TFVGTSTYMSPERIQGNVYSIKGDVWSLGLMIIELVTGEFPLGGHNDTPDG-----ILDL 417 Query: 940 LEAIVDQPPPSAPADQ-FSPEFCSFISSCIQKDPAERKSASELLNHAFIKKFEDKDLD 1110 L+ IV++P P P D+ +S E F++ C K+ ER S ELL+H I K+ D Sbjct: 418 LQRIVNEPSPRLPKDRIYSKEMTDFVNRCCIKNERERSSIHELLHHDLIMKYVSPSKD 475
>A4K2W5:STK4_AOTNA Serine/threonine-protein kinase 4 - Aotus nancymaae (Ma's night| monkey) Length = 487 Score = 167 bits (422), Expect = 1e-40 Identities = 97/309 (31%), Positives = 173/309 (55%), Gaps = 3/309 (0%) Frame = +1 Query: 220 LQLISEENGDEHQSTKMKVEDVQLSMDDL-EMIQVIGKGSGGVVQLVRHKWVGTFYALKG 396 ++ + N Q K+ + + +++ ++++ +G+GS G V HK G A+K Sbjct: 1 METVQLRNPPRRQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQ 60 Query: 397 IQMNIQESVRKQIVQELKINQATQSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIK-Q 573 + + ES ++I++E+ I Q S H+V + S++ N +++V+EY GS++DII+ + Sbjct: 61 VPV---ESDLQEIIKEISIMQQCDSHHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLR 117 Query: 574 VKTILEPYLAVLCKQVLEGLLYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLAS 753 KT+ E +A + + L+GL YLH R IHRDIK N+L+N +G K+ DFGV+ L Sbjct: 118 NKTLTEDEIATILQSTLKGLEYLHFMRK-IHRDIKAGNILLNTEGHAKLADFGVAGQLTD 176 Query: 754 SIGQRDTFVGTYNYMAPERISGSSYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFY 933 ++ +R+T +GT +MAPE I Y+ +D+WSLG+ +E A G+ PY + Sbjct: 177 TMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYAD------IHPM 230 Query: 934 ELLEAIVDQPPPS-APADQFSPEFCSFISSCIQKDPAERKSASELLNHAFIKKFEDKDLD 1110 + I PPP+ + +S F F+ C+ K P +R +A++LL H F+K + + Sbjct: 231 RAIFMIPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFVKSAKGVSIL 290 Query: 1111 LRILVESLE 1137 ++ E+++ Sbjct: 291 RDLINEAMD 299
>Q6PA14:STK4_XENLA Serine/threonine-protein kinase 4 - Xenopus laevis (African clawed| frog) Length = 485 Score = 166 bits (420), Expect = 2e-40 Identities = 102/309 (33%), Positives = 174/309 (56%), Gaps = 3/309 (0%) Frame = +1 Query: 220 LQLISEENGDEHQSTKMKVEDVQLSMDDL-EMIQVIGKGSGGVVQLVRHKWVGTFYALKG 396 ++ + N K+ E + +++ ++++ +G+GS G V HK A+K Sbjct: 1 METVQLRNNPRRHLKKLSEESLNKQPEEVFDVLEKLGEGSYGSVYKASHKETSQIVAIKQ 60 Query: 397 IQMNIQESVRKQIVQELKINQATQSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQV 576 I + ES ++I++E+ I Q SPH+V + S++ N +++V+E+ GS++DII+ Sbjct: 61 IPV---ESDLQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEFCGGGSVSDIIRLR 117 Query: 577 K-TILEPYLAVLCKQVLEGLLYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLAS 753 K T+ E +A + + L+GL YLH R IHRDIK N+L++ +G K+ DFGV+ L Sbjct: 118 KQTLNEDEIATILQSTLKGLEYLHFMRK-IHRDIKAGNILLSCEGTAKLADFGVAGQLTD 176 Query: 754 SIGQRDTFVGTYNYMAPERISGSSYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFY 933 ++ +R+T +GT +MAPE I Y+ +D+WSLG+ +E A G+ PY + Sbjct: 177 TMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYAE------IHPM 230 Query: 934 ELLEAIVDQPPPS-APADQFSPEFCSFISSCIQKDPAERKSASELLNHAFIKKFEDKDLD 1110 + I PPP+ + +S +F FI+ C+ K+P R SA+ELL H FIK + + + Sbjct: 231 RAIFMIPSNPPPTFRKPELWSKDFVDFINLCLVKNPELRSSATELLQHPFIKAAKGESI- 289 Query: 1111 LRILVESLE 1137 LR L+ + + Sbjct: 290 LRHLLNAAQ 298
>O14047:PPK11_SCHPO Serine/threonine-protein kinase ppk11 - Schizosaccharomyces pombe| (Fission yeast) Length = 312 Score = 166 bits (420), Expect = 2e-40 Identities = 96/260 (36%), Positives = 144/260 (55%) Frame = +1 Query: 313 IQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQIVQELKINQATQSPHIVLCH 492 +Q+IG+GS G V + ALK + ++ + + + QE+ S HI + Sbjct: 9 LQLIGQGSFGSVFRAQDVESSKIVALKVVDLDATKDQIETLTQEINFLIDLNSVHITKYY 68 Query: 493 QSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLYLHHERHVIHRD 672 SF +++ +EY D GS D++K T E +A + +QVLE L+YLH + + HRD Sbjct: 69 ASFVDGFRLWITMEYCDGGSCLDLLKLSGTFSERVIAEVMRQVLEALVYLHGQGKM-HRD 127 Query: 673 IKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISGSSYDYKSDVWS 852 IK +N+L G VK+ DFGVS L S + D FVGT +MAPE + + Y+YK+D+WS Sbjct: 128 IKAANILTMKDGLVKLADFGVSGQLESLRDKNDDFVGTPFWMAPEVVKQTGYNYKADIWS 187 Query: 853 LGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAPADQFSPEFCSFISSCIQK 1032 LG+ E A G PY+ + ++L I PPS +FS FC F+S+C++K Sbjct: 188 LGITAYELATGEPPYS------GIHPMKVLLLIPKHSPPSLERSKFSRAFCDFVSNCLKK 241 Query: 1033 DPAERKSASELLNHAFIKKF 1092 +P +R +A L H FIKK+ Sbjct: 242 NPKDRATAEYLSKHKFIKKY 261
>P47809:MP2K4_MOUSE Dual specificity mitogen-activated protein kinase kinase 4 - Mus| musculus (Mouse) Length = 397 Score = 166 bits (419), Expect = 3e-40 Identities = 119/370 (32%), Positives = 190/370 (51%), Gaps = 20/370 (5%) Frame = +1 Query: 76 HSKEEAMRGKKPLKELTLSVPAQETPVDKFLTASGTFKDGELRLNQRGLQLISEENGDEH 255 H +M+GK+ +L + P ++ TA T L N G+Q E H Sbjct: 29 HPAVSSMQGKRKALKLNFANPPVKS------TARFT-----LNPNTTGVQNPHIERLRTH 77 Query: 256 Q---STKMKVEDVQ---LSMDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQE 417 S K+K+ Q + +DL+ + IG+G+ G V + HK G A+K I+ + E Sbjct: 78 SIESSGKLKISPEQHWDFTAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDE 137 Query: 418 SVRKQIVQELKI-NQATQSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTIL-- 588 +KQ++ +L + +++ P+IV + + + G ++ +E M S K V ++L Sbjct: 138 KEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMST-SFDKFYKYVYSVLDD 196 Query: 589 ---EPYLAVLCKQVLEGLLYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSI 759 E L + ++ L +L +IHRDIKPSN+L++ G +K+ DFG+S L SI Sbjct: 197 VIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSI 256 Query: 760 GQ-RDTFVGTYNYMAPERISGSS----YDYKSDVWSLGLVILECAIGRFPYTPPEGEGWL 924 + RD G YMAPERI S+ YD +SDVWSLG+ + E A GRFPY W Sbjct: 257 AKTRD--AGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPK-----WN 309 Query: 925 SFYELLEAIVDQPPP---SAPADQFSPEFCSFISSCIQKDPAERKSASELLNHAFIKKFE 1095 S ++ L +V PP ++ +FSP F +F++ C+ KD ++R ELL H FI +E Sbjct: 310 SVFDQLTQVVKGDPPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFILMYE 369 Query: 1096 DKDLDLRILV 1125 ++ +++ V Sbjct: 370 ERTVEVACYV 379
>Q9Z2W1:STK25_MOUSE Serine/threonine-protein kinase 25 - Mus musculus (Mouse)| Length = 426 Score = 165 bits (418), Expect = 4e-40 Identities = 104/295 (35%), Positives = 162/295 (54%) Frame = +1 Query: 244 GDEHQSTKMKVEDVQLSMDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESV 423 G HQ +++ E++ +D IGKGS G V A+K I + E Sbjct: 6 GFAHQHSRVDPEELFTKLDR------IGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDE 59 Query: 424 RKQIVQELKINQATQSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLA 603 + I QE+ + SP+I S+ + +++++EY+ GS D++K + E Y+A Sbjct: 60 IEDIQQEITVLSQCDSPYITRYFGSYLKSTKLWIIMEYLGGGSALDLLKP-GPLEETYIA 118 Query: 604 VLCKQVLEGLLYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVG 783 + +++L+GL YLH ER IHRDIK +N+L++ +G+VK+ DFGV+ L + +R+TFVG Sbjct: 119 TILREILKGLDYLHSERK-IHRDIKAANVLLSEQGDVKMADFGVAGQLTDTQIKRNTFVG 177 Query: 784 TYNYMAPERISGSSYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQP 963 T +MAPE I S+YD+K+D+WSLG+ +E A G PP + L +L I Sbjct: 178 TPFWMAPEVIKQSAYDFKADIWSLGITAIELAKGE----PPNSD--LHPMRVLFLIPKNN 231 Query: 964 PPSAPADQFSPEFCSFISSCIQKDPAERKSASELLNHAFIKKFEDKDLDLRILVE 1128 PP+ P F F+ +C+ KDP R +A ELL H FI ++ K L L++ Sbjct: 232 PPTLEGHHSKP-FKEFVEACLNKDPRFRPTAKELLKHKFITRYTKKTSFLTELID 285
>Q6P3Q4:STK4_XENTR Serine/threonine-protein kinase 4 - Xenopus tropicalis (Western| clawed frog) (Silurana tropicalis) Length = 485 Score = 164 bits (416), Expect = 6e-40 Identities = 102/309 (33%), Positives = 171/309 (55%), Gaps = 3/309 (0%) Frame = +1 Query: 220 LQLISEENGDEHQSTKMKVEDVQLSMDDL-EMIQVIGKGSGGVVQLVRHKWVGTFYALKG 396 ++ + N K+ E + +++ ++++ +G+GS G V HK A+K Sbjct: 1 METVQLRNNPRRHLKKLSEESLNKQPEEVFDVLEKLGEGSYGSVYKASHKETSQIVAIKQ 60 Query: 397 IQMNIQESVRKQIVQELKINQATQSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQV 576 I + ES ++I++E+ I Q S H+V + S++ N +++V+E+ GS++DII+ Sbjct: 61 IPV---ESDLQEIIKEIAIMQQCDSLHVVKYYGSYFKNTDLWIVMEFCGGGSISDIIRLR 117 Query: 577 K-TILEPYLAVLCKQVLEGLLYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLAS 753 K T+ E A + + L+GL YLH R IHRDIK N+L+N +G K+ DFGV+ L Sbjct: 118 KQTLKEDETATILQSTLKGLEYLHFMRK-IHRDIKAGNILLNSEGTAKLADFGVAGQLTD 176 Query: 754 SIGQRDTFVGTYNYMAPERISGSSYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFY 933 ++ +R+T +GT +MAPE I Y+ +D+WSLG+ +E A G+ PY + Sbjct: 177 TMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYAE------IHPM 230 Query: 934 ELLEAIVDQPPPS-APADQFSPEFCSFISSCIQKDPAERKSASELLNHAFIKKFEDKDLD 1110 + I PPP+ + +S +F FI+ C+ K+P R SA+ELL H FIK + + + Sbjct: 231 RAIFMIPSNPPPTFRKPELWSKDFVDFINLCLVKNPELRSSATELLQHPFIKTAKGESI- 289 Query: 1111 LRILVESLE 1137 LR L+ + Sbjct: 290 LRHLINEAQ 298
>Q5ZJK4:STK4_CHICK Serine/threonine-protein kinase 4 - Gallus gallus (Chicken)| Length = 486 Score = 164 bits (415), Expect = 8e-40 Identities = 94/279 (33%), Positives = 160/279 (57%), Gaps = 2/279 (0%) Frame = +1 Query: 307 EMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQIVQELKINQATQSPHIVL 486 ++++ +G+GS G V HK G A+K + + ES ++I++E+ I Q SPH+V Sbjct: 30 DVLEKLGEGSYGSVFKAIHKETGQVVAIKQVPV---ESDLQEIIKEISIMQQCDSPHVVK 86 Query: 487 CHQSFYHNGVIYLVLEYMDRGSLADIIK-QVKTILEPYLAVLCKQVLEGLLYLHHERHVI 663 + S++ N +++V+EY GS++DII+ + KT+ E +A + + L+GL YLH R I Sbjct: 87 YYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEEEIATIVQSTLKGLEYLHFMRK-I 145 Query: 664 HRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISGSSYDYKSD 843 HRDIK N+L+N +G K+ DFGV+ L ++ +R+T +GT +MAP I Y+ +D Sbjct: 146 HRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPGVIQEIGYNCVAD 205 Query: 844 VWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPS-APADQFSPEFCSFISS 1020 +WSLG+ +E A G+ PY + + I PPP+ + +S F F+ Sbjct: 206 IWSLGITAIEMAEGKPPYAD------IHPMRAIFMIPTNPPPTFRKPELWSDAFTDFVKQ 259 Query: 1021 CIQKDPAERKSASELLNHAFIKKFEDKDLDLRILVESLE 1137 C+ K P +R +A +LL H F+K + + ++ E+++ Sbjct: 260 CLVKSPEQRATAIQLLQHPFVKSAKGASILRDLINEAMD 298
>Q6IP06:STK3_XENLA Serine/threonine-protein kinase 3 - Xenopus laevis (African clawed| frog) Length = 493 Score = 164 bits (415), Expect = 8e-40 Identities = 94/279 (33%), Positives = 163/279 (58%), Gaps = 2/279 (0%) Frame = +1 Query: 307 EMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQIVQELKINQATQSPHIVL 486 ++++ +G+GS G V HK G A+K + + ES ++I++E+ I Q S ++V Sbjct: 27 DVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPV---ESDLQEIIKEISIMQQCDSHYVVK 83 Query: 487 CHQSFYHNGVIYLVLEYMDRGSLADIIK-QVKTILEPYLAVLCKQVLEGLLYLHHERHVI 663 + S++ N +++V+EY GS++DII+ + KT+ E +A + + L+GL YLH R I Sbjct: 84 YYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILRSTLKGLEYLHFMRK-I 142 Query: 664 HRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISGSSYDYKSD 843 HRDIK N+L+N +G K+ DFGV+ L ++ +R+T +GT +MAPE I Y+ +D Sbjct: 143 HRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVAD 202 Query: 844 VWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPS-APADQFSPEFCSFISS 1020 +WSLG+ +E A G+ PY + + I PPP+ + ++ EF F+ Sbjct: 203 IWSLGITSIEMAEGKPPYAD------IHPMRAIFMIPTNPPPTFRKPELWTDEFTDFVKK 256 Query: 1021 CIQKDPAERKSASELLNHAFIKKFEDKDLDLRILVESLE 1137 C+ K+P +R +A++LL H FIK + + ++ E+++ Sbjct: 257 CLVKNPEQRATATQLLQHPFIKNAKPVSILRDLITEAMD 295
>O00506:STK25_HUMAN Serine/threonine-protein kinase 25 - Homo sapiens (Human)| Length = 426 Score = 164 bits (415), Expect = 8e-40 Identities = 104/295 (35%), Positives = 163/295 (55%) Frame = +1 Query: 244 GDEHQSTKMKVEDVQLSMDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESV 423 G +Q +++ E++ +D IGKGS G V A+K I + E Sbjct: 6 GFANQHSRVDPEELFTKLDR------IGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDE 59 Query: 424 RKQIVQELKINQATQSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLA 603 + I QE+ + SP+I S+ + +++++EY+ GS D++K + E Y+A Sbjct: 60 IEDIQQEITVLSQCDSPYITRYFGSYLKSTKLWIIMEYLGGGSALDLLKP-GPLEETYIA 118 Query: 604 VLCKQVLEGLLYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVG 783 + +++L+GL YLH ER IHRDIK +N+L++ +G+VK+ DFGV+ L + +R+TFVG Sbjct: 119 TILREILKGLDYLHSERK-IHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVG 177 Query: 784 TYNYMAPERISGSSYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQP 963 T +MAPE I S+YD+K+D+WSLG+ +E A G PP + L +L I Sbjct: 178 TPFWMAPEVIKQSAYDFKADIWSLGITAIELAKGE----PPNSD--LHPMRVLFLIPKNS 231 Query: 964 PPSAPADQFSPEFCSFISSCIQKDPAERKSASELLNHAFIKKFEDKDLDLRILVE 1128 PP+ Q S F F+ +C+ KDP R +A ELL H FI ++ K L L++ Sbjct: 232 PPTLEG-QHSKPFKEFVEACLNKDPRFRPTAKELLKHKFITRYTKKTSFLTELID 285
>Q3SWY6:STK25_BOVIN Serine/threonine-protein kinase 25 - Bos taurus (Bovine)| Length = 426 Score = 163 bits (412), Expect = 2e-39 Identities = 103/295 (34%), Positives = 162/295 (54%) Frame = +1 Query: 244 GDEHQSTKMKVEDVQLSMDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESV 423 G +Q +++ E++ +D IGKGS G V A+K I + E Sbjct: 6 GFANQHSRVDPEELFTKLDR------IGKGSFGEVYKGIDNRTKEVVAIKIIDLEEAEDE 59 Query: 424 RKQIVQELKINQATQSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLA 603 + I QE+ + SP+I S+ + +++++EY+ GS D++K + E Y+A Sbjct: 60 IEDIQQEITVLSQCDSPYITRYFGSYLKSTKLWIIMEYLGGGSALDLLKP-GPLEETYIA 118 Query: 604 VLCKQVLEGLLYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVG 783 + +++L+GL YLH ER IHRDIK +N+L++ +G+VK+ DFGV+ L + +R+TFVG Sbjct: 119 TILREILKGLDYLHSERK-IHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVG 177 Query: 784 TYNYMAPERISGSSYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQP 963 T +MAPE I S+YD+K+D+WSLG+ +E A G PP + L +L I Sbjct: 178 TPFWMAPEVIKQSAYDFKADIWSLGITAIELAKGE----PPNSD--LHPMRVLFLIPKNS 231 Query: 964 PPSAPADQFSPEFCSFISSCIQKDPAERKSASELLNHAFIKKFEDKDLDLRILVE 1128 PP+ P F F+ +C+ KDP R +A ELL H FI ++ K L L++ Sbjct: 232 PPTLEGHHSKP-FKEFVEACLNKDPRFRPTAKELLKHKFITRYTKKTSFLTELID 285
>O94804:STK10_HUMAN Serine/threonine-protein kinase 10 - Homo sapiens (Human)| Length = 968 Score = 163 bits (412), Expect = 2e-39 Identities = 103/341 (30%), Positives = 180/341 (52%), Gaps = 9/341 (2%) Frame = +1 Query: 277 EDVQLSMDDLEMIQVIGK---GSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQIVQEL 447 E V+ +D E+ +++G+ G+ G V ++K G A K I+ +E + IV E+ Sbjct: 24 EHVRRDLDPNEVWEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIV-EI 82 Query: 448 KINQATQSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQV-KTILEPYLAVLCKQVL 624 +I P+IV ++YH+G +++++E+ G++ I+ ++ + + EP + V+C+Q+L Sbjct: 83 EILATCDHPYIVKLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQML 142 Query: 625 EGLLYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAP 804 E L +LH +R +IHRD+K N+L+ +G++++ DFGVSA ++ +RD+F+GT +MAP Sbjct: 143 EALNFLHSKR-IIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAP 201 Query: 805 -----ERISGSSYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPP 969 E + + YDYK+D+WSLG+ ++E A PP E LL+ PP Sbjct: 202 EVVMCETMKDTPYDYKADIWSLGITLIEMA----QIEPPHHE-LNPMRVLLKIAKSDPPT 256 Query: 970 SAPADQFSPEFCSFISSCIQKDPAERKSASELLNHAFIKKFEDKDLDLRILVESLEQPMN 1149 ++S EF F+ + K+P R SA++LL H F+ ++ E+ + M Sbjct: 257 LLTPSKWSVEFRDFLKIALDKNPETRPSAAQLLEHPFVSSITSNKALRELVAEAKAEVME 316 Query: 1150 VPE*GLPLGEARLCGDSLPGPPSRRQSCNCCEPGGFTDDAP 1272 E G GE D+ + Q+ + P D P Sbjct: 317 EIEDGRDEGEEEDAVDAASTLENHTQNSSEVSPPSLNADKP 357
>Q07192:MP2K2_XENLA Dual specificity mitogen-activated protein kinase kinase 2 - Xenopus| laevis (African clawed frog) Length = 446 Score = 163 bits (412), Expect = 2e-39 Identities = 107/315 (33%), Positives = 169/315 (53%), Gaps = 17/315 (5%) Frame = +1 Query: 259 STKMKVEDVQ---LSMDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRK 429 S K+K+ Q + +DL+ + IG+G+ G V + H G A+K I+ + E +K Sbjct: 131 SGKLKLSPEQHWDFTAEDLKDLGEIGRGAYGSVNKMSHTPSGQIMAVKRIRSTVDEKEQK 190 Query: 430 QIVQELKI-NQATQSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTIL-----E 591 Q++ +L + +++ P+IV + + + G ++ +E M S K V + L E Sbjct: 191 QLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMAT-SFDKFYKYVYSFLDDVIPE 249 Query: 592 PYLAVLCKQVLEGLLYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQ-R 768 L + ++ L +L +IHRDIKPSN+L++ G +K+ DFG+S L SI + R Sbjct: 250 EILGKITLATVKALNHLKENLKIIHRDIKPSNILLDTNGNIKLCDFGISGQLVDSIAKTR 309 Query: 769 DTFVGTYNYMAPERISGSS----YDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYE 936 D G YMAPERI S+ YD +SDVWSLG+ + E A GRFPY W S ++ Sbjct: 310 D--AGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPK-----WNSVFD 362 Query: 937 LLEAIVDQPPP---SAPADQFSPEFCSFISSCIQKDPAERKSASELLNHAFIKKFEDKDL 1107 L +V PP ++ +FSP F SF++ C+ KD ++R ELL H FI +E++ + Sbjct: 363 QLTQVVKGDPPQLSNSEEREFSPSFTSFVNQCLTKDESKRPKYKELLKHPFILMYEERTV 422 Query: 1108 DLRILVESLEQPMNV 1152 D+ V + + M V Sbjct: 423 DVAGYVGKILEQMPV 437
>O55098:STK10_MOUSE Serine/threonine-protein kinase 10 - Mus musculus (Mouse)| Length = 966 Score = 160 bits (406), Expect = 9e-39 Identities = 101/324 (31%), Positives = 176/324 (54%), Gaps = 7/324 (2%) Frame = +1 Query: 298 DDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQIVQELKINQATQSPH 477 D E++ +G G+ G V ++K G A K I+ +E + IV E++I P+ Sbjct: 34 DVWEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIV-EIEILATCDHPY 92 Query: 478 IVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQV-KTILEPYLAVLCKQVLEGLLYLHHER 654 IV ++Y++G +++++E+ G++ I+ ++ + + EP + V+C+Q+LE L +LH +R Sbjct: 93 IVKLLGAYYYDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLHGKR 152 Query: 655 HVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAP-----ERISG 819 +IHRD+K N+L+ +G++++ DFGVSA ++ +RD+F+GT +MAP E + Sbjct: 153 -IIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVLCETMKD 211 Query: 820 SSYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAPADQFSPE 999 + YDYK+D+WSLG+ ++E A PP E LL+ PP ++S E Sbjct: 212 APYDYKADIWSLGITLIEMA----QIEPPHHE-LNPMRVLLKIAKSDPPTLLTPSKWSVE 266 Query: 1000 FCSFISSCIQKDPAERKSASELLNHAFIKKFEDKDLDLRILVESLEQPMNVPE*GLPLGE 1179 F F+ + K+P R SA++LL H F+ + ++ E+ + M E G GE Sbjct: 267 FRDFLKIALDKNPETRPSAAQLLQHPFVSRVTSNKALRELVAEAKAEVMEEIEDGREDGE 326 Query: 1180 ARLCGDSLPGPPSRRQ-SCNCCEP 1248 D++P + Q S N +P Sbjct: 327 EEDAVDAVPPLVNHTQDSANVTQP 350
>O95819:M4K4_HUMAN Mitogen-activated protein kinase kinase kinase kinase 4 - Homo| sapiens (Human) Length = 1239 Score = 159 bits (402), Expect = 3e-38 Identities = 99/276 (35%), Positives = 156/276 (56%), Gaps = 16/276 (5%) Frame = +1 Query: 307 EMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQIVQELKINQATQSPH--- 477 E+++V+G G+ G V RH G A+K M++ E ++I +L+IN + H Sbjct: 26 ELVEVVGNGTYGQVYKGRHVKTGQLAAIK--VMDVTEDEEEEI--KLEINMLKKYSHHRN 81 Query: 478 IVLCHQSFY------HNGVIYLVLEYMDRGSLADIIKQVK--TILEPYLAVLCKQVLEGL 633 I + +F H+ ++LV+E+ GS+ D++K K T+ E ++A + +++L GL Sbjct: 82 IATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGL 141 Query: 634 LYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERI 813 +LH HVIHRDIK N+L+ EVK+ DFGVSA L ++G+R+TF+GT +MAPE I Sbjct: 142 AHLHIH-HVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVI 200 Query: 814 S-----GSSYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAP 978 + ++YDY+SD+WS G+ +E A G P + L I PPP Sbjct: 201 ACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCD------MHPMRALFLIPRNPPPRLK 254 Query: 979 ADQFSPEFCSFISSCIQKDPAERKSASELLNHAFIK 1086 + ++S +F SFI C+ K+ +R S +LL H FI+ Sbjct: 255 SKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIR 290
>O14733:MP2K7_HUMAN Dual specificity mitogen-activated protein kinase kinase 7 - Homo| sapiens (Human) Length = 419 Score = 156 bits (395), Expect = 2e-37 Identities = 94/285 (32%), Positives = 164/285 (57%), Gaps = 9/285 (3%) Frame = +1 Query: 286 QLSMDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQIVQELKIN-QA 462 Q ++DLE + +G G+ G V +R + G A+K ++ + + K+I+ +L + ++ Sbjct: 114 QAEINDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKS 173 Query: 463 TQSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKT--ILEPYLAVLCKQVLEGLL 636 P+IV C +F N +++ +E M G+ A+ +K+ I E L + +++ L Sbjct: 174 HDCPYIVQCFGTFITNTDVFIAMELM--GTCAEKLKKRMQGPIPERILGKMTVAIVKALY 231 Query: 637 YLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERI- 813 YL + VIHRD+KPSN+L++ +G++K+ DFG+S L S + + G YMAPERI Sbjct: 232 YLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRS-AGCAAYMAPERID 290 Query: 814 ----SGSSYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAPA 981 + YD ++DVWSLG+ ++E A G+FPY + + +E+L ++ + PP P Sbjct: 291 PPDPTKPDYDIRADVWSLGISLVELATGQFPY-----KNCKTDFEVLTKVLQEEPPLLPG 345 Query: 982 DQ-FSPEFCSFISSCIQKDPAERKSASELLNHAFIKKFEDKDLDL 1113 FS +F SF+ C+ KD +R ++LL H+FIK++E ++D+ Sbjct: 346 HMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKRYETLEVDV 390
>Q9P289:MST4_HUMAN Serine/threonine-protein kinase MST4 - Homo sapiens (Human)| Length = 416 Score = 156 bits (394), Expect = 2e-37 Identities = 102/300 (34%), Positives = 163/300 (54%), Gaps = 4/300 (1%) Frame = +1 Query: 253 HQSTKMKVEDVQLSMDDLE----MIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQES 420 H ++V +Q ++ D E ++ IGKGS G V A+K I + E Sbjct: 3 HSPVAVQVPGMQNNIADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAED 62 Query: 421 VRKQIVQELKINQATQSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYL 600 + I QE+ + S ++ + S+ +++++EY+ GS D+++ E + Sbjct: 63 EIEDIQQEITVLSQCDSSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLR-AGPFDEFQI 121 Query: 601 AVLCKQVLEGLLYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFV 780 A + K++L+GL YLH E+ IHRDIK +N+L++ +G+VK+ DFGV+ L + +R+TFV Sbjct: 122 ATMLKEILKGLDYLHSEKK-IHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFV 180 Query: 781 GTYNYMAPERISGSSYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQ 960 GT +MAPE I S+YD K+D+WSLG+ +E A G PP + + +L I Sbjct: 181 GTPFWMAPEVIQQSAYDSKADIWSLGITAIELAKGE----PPNSD--MHPMRVLFLIPKN 234 Query: 961 PPPSAPADQFSPEFCSFISSCIQKDPAERKSASELLNHAFIKKFEDKDLDLRILVESLEQ 1140 PP+ D F+ F FI +C+ KDP+ R +A ELL H FI K K L L++ ++ Sbjct: 235 NPPTLVGD-FTKSFKEFIDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFKR 293
>Q99JT2:MST4_MOUSE Serine/threonine-protein kinase MST4 - Mus musculus (Mouse)| Length = 416 Score = 155 bits (393), Expect = 3e-37 Identities = 102/300 (34%), Positives = 163/300 (54%), Gaps = 4/300 (1%) Frame = +1 Query: 253 HQSTKMKVEDVQLSMDDLE----MIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQES 420 H ++V +Q ++ D E ++ IGKGS G V A+K I + E Sbjct: 3 HSPVAVQVPGMQNNIADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAED 62 Query: 421 VRKQIVQELKINQATQSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYL 600 + I QE+ + S ++ + S+ +++++EY+ GS D+++ E + Sbjct: 63 EIEDIQQEITVLSQCDSSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLR-AGPFDEFQI 121 Query: 601 AVLCKQVLEGLLYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFV 780 A + K++L+GL YLH E+ IHRDIK +N+L++ +G+VK+ DFGV+ L + +R+TFV Sbjct: 122 ATMLKEILKGLDYLHSEKK-IHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFV 180 Query: 781 GTYNYMAPERISGSSYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQ 960 GT +MAPE I S+YD K+D+WSLG+ +E A G PP + + +L I Sbjct: 181 GTPFWMAPEVIQQSAYDSKADIWSLGITAIELAKGE----PPNSD--MHPMRVLFLIPKN 234 Query: 961 PPPSAPADQFSPEFCSFISSCIQKDPAERKSASELLNHAFIKKFEDKDLDLRILVESLEQ 1140 PP+ D F+ F FI +C+ KDP+ R +A ELL H FI K K L L++ ++ Sbjct: 235 NPPTLIGD-FTKSFKEFIDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFKR 293
>Q4KSH7:MP2K7_RAT Dual specificity mitogen-activated protein kinase kinase 7 - Rattus| norvegicus (Rat) Length = 419 Score = 155 bits (393), Expect = 3e-37 Identities = 94/285 (32%), Positives = 163/285 (57%), Gaps = 9/285 (3%) Frame = +1 Query: 286 QLSMDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQIVQELKIN-QA 462 Q ++DLE + +G G+ G V +R + G A+K ++ + + K+I+ +L + ++ Sbjct: 114 QAEINDLENLGEMGSGTCGQVWKMRFRKTGHIIAVKQMRRSGNKEENKRILMDLDVVLKS 173 Query: 463 TQSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKT--ILEPYLAVLCKQVLEGLL 636 P+IV C +F N +++ +E M G+ A+ +K+ I E L + +++ L Sbjct: 174 HDCPYIVQCFGTFITNTDVFIAMELM--GTCAEKLKKRMQGPIPERILGKMTVAIVKALY 231 Query: 637 YLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERI- 813 YL + VIHRD+KPSN+L++ +G++K+ DFG+S L S + + G YMAPERI Sbjct: 232 YLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRS-AGCAAYMAPERID 290 Query: 814 ----SGSSYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAPA 981 + YD ++DVWSLG+ ++E A G+FPY + + +E+L ++ + PP P Sbjct: 291 PPDPTKPDYDIRADVWSLGISLVELATGQFPY-----KNCKTDFEVLTKVLQEEPPLLPG 345 Query: 982 DQ-FSPEFCSFISSCIQKDPAERKSASELLNHAFIKKFEDKDLDL 1113 FS +F SF+ C+ KD +R ++LL H+FIK +E ++D+ Sbjct: 346 HMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKHYETLEVDV 390
>P83510:TNIK_MOUSE Traf2 and NCK-interacting protein kinase - Mus musculus (Mouse)| Length = 916 Score = 155 bits (391), Expect = 5e-37 Identities = 94/274 (34%), Positives = 156/274 (56%), Gaps = 14/274 (5%) Frame = +1 Query: 307 EMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQIVQELK-INQATQSPHIV 483 E+++++G G+ G V RH G A+K M++ ++I QE+ + + + +I Sbjct: 26 ELVELVGNGTYGQVYKGRHVKTGQLAAIK--VMDVTGDEEEEIKQEINMLKKYSHHRNIA 83 Query: 484 LCHQSFYHNGV------IYLVLEYMDRGSLADIIKQVK--TILEPYLAVLCKQVLEGLLY 639 + +F ++LV+E+ GS+ D+IK K T+ E ++A +C+++L GL + Sbjct: 84 TYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSH 143 Query: 640 LHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERIS- 816 LH + VIHRDIK N+L+ EVK+ DFGVSA L ++G+R+TF+GT +MAPE I+ Sbjct: 144 LHQHK-VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIAC 202 Query: 817 ----GSSYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAPAD 984 ++YD+KSD+WSLG+ +E A G P + L I P P + Sbjct: 203 DENPDATYDFKSDLWSLGITAIEMAEGAPPLCD------MHPMRALFLIPRNPAPRLKSK 256 Query: 985 QFSPEFCSFISSCIQKDPAERKSASELLNHAFIK 1086 ++S +F SFI SC+ K+ ++R + +L+ H FI+ Sbjct: 257 KWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIR 290
>Q9UKE5:TNIK_HUMAN TRAF2 and NCK-interacting protein kinase - Homo sapiens (Human)| Length = 1360 Score = 155 bits (391), Expect = 5e-37 Identities = 94/274 (34%), Positives = 156/274 (56%), Gaps = 14/274 (5%) Frame = +1 Query: 307 EMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQIVQELK-INQATQSPHIV 483 E+++++G G+ G V RH G A+K M++ ++I QE+ + + + +I Sbjct: 26 ELVELVGNGTYGQVYKGRHVKTGQLAAIK--VMDVTGDEEEEIKQEINMLKKYSHHRNIA 83 Query: 484 LCHQSFYHNGV------IYLVLEYMDRGSLADIIKQVK--TILEPYLAVLCKQVLEGLLY 639 + +F ++LV+E+ GS+ D+IK K T+ E ++A +C+++L GL + Sbjct: 84 TYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSH 143 Query: 640 LHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERIS- 816 LH + VIHRDIK N+L+ EVK+ DFGVSA L ++G+R+TF+GT +MAPE I+ Sbjct: 144 LHQHK-VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIAC 202 Query: 817 ----GSSYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAPAD 984 ++YD+KSD+WSLG+ +E A G P + L I P P + Sbjct: 203 DENPDATYDFKSDLWSLGITAIEMAEGAPPLCD------MHPMRALFLIPRNPAPRLKSK 256 Query: 985 QFSPEFCSFISSCIQKDPAERKSASELLNHAFIK 1086 ++S +F SFI SC+ K+ ++R + +L+ H FI+ Sbjct: 257 KWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIR 290
>P50527:STE20_SCHPO Serine/threonine-protein kinase shk1/pak1 - Schizosaccharomyces pombe| (Fission yeast) Length = 658 Score = 155 bits (391), Expect = 5e-37 Identities = 94/257 (36%), Positives = 152/257 (59%), Gaps = 1/257 (0%) Frame = +1 Query: 322 IGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQ-IVQELKINQATQSPHIVLCHQS 498 IG+G+ G V R VGT ++ +MNI + +K+ IV E+ + ++ +IV + Sbjct: 392 IGQGASGDVYSARQ--VGTNLSVAIKKMNINQQPKKEFIVNEILVMKSHHHKNIVNFIDT 449 Query: 499 FYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLYLHHERHVIHRDIK 678 F++ +++V+EYM GSL +++ T+ E +A +CK+ LEGL +LH E ++HRDIK Sbjct: 450 FFYKSELWMVMEYMRGGSLTEVVTN-NTLSEGQIAAICKETLEGLQHLH-ENGIVHRDIK 507 Query: 679 PSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISGSSYDYKSDVWSLG 858 N+L++ +G++K+TDFG A + S++ +R T VGT +MAPE ++ Y +K DVWSLG Sbjct: 508 SDNILLSLQGDIKLTDFGFCAQIDSNMTKRTTMVGTPYWMAPEVVTRKEYGFKVDVWSLG 567 Query: 859 LVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAPADQFSPEFCSFISSCIQKDP 1038 ++ +E G PY E L L+ A + P S P + S F F+S + +P Sbjct: 568 IMAIEMVEGEPPYL---NENPLRALYLI-ATIGTPKISRP-ELLSSVFHDFLSKSLTVNP 622 Query: 1039 AERKSASELLNHAFIKK 1089 +R S+ ELL H F+K+ Sbjct: 623 KQRPSSGELLRHPFLKQ 639
>Q8CE90:MP2K7_MOUSE Dual specificity mitogen-activated protein kinase kinase 7 - Mus| musculus (Mouse) Length = 535 Score = 155 bits (391), Expect = 5e-37 Identities = 94/285 (32%), Positives = 163/285 (57%), Gaps = 9/285 (3%) Frame = +1 Query: 286 QLSMDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQIVQELKIN-QA 462 Q ++DLE + +G G+ G V +R + G A+K ++ + + K+I+ +L + ++ Sbjct: 130 QAEINDLENLGEMGSGTCGQVWKMRFRKTGHIIAVKQMRRSGNKEENKRILMDLDVVLKS 189 Query: 463 TQSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKT--ILEPYLAVLCKQVLEGLL 636 P+IV C +F N +++ +E M G+ A+ +K+ I E L + +++ L Sbjct: 190 HDCPYIVQCFGTFITNTDVFIAMELM--GTCAEKLKKRMQGPIPERILGKMTVAIVKALY 247 Query: 637 YLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERI- 813 YL + VIHRD+KPSN+L++ +G++K+ DFG+S L S + + G YMAPERI Sbjct: 248 YLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRS-AGCAAYMAPERID 306 Query: 814 ----SGSSYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAPA 981 + YD ++DVWSLG+ ++E A G+FPY + + +E+L ++ + PP P Sbjct: 307 PPDPTKPDYDIRADVWSLGISLVELATGQFPY-----KNCKTDFEVLTKVLQEEPPLLPG 361 Query: 982 DQ-FSPEFCSFISSCIQKDPAERKSASELLNHAFIKKFEDKDLDL 1113 FS +F SF+ C+ KD +R ++LL H+FIK +E ++D+ Sbjct: 362 HMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKHYEILEVDV 406
>Q9Y6E0:STK24_HUMAN Serine/threonine-protein kinase 24 - Homo sapiens (Human)| Length = 443 Score = 153 bits (387), Expect = 1e-36 Identities = 99/290 (34%), Positives = 160/290 (55%) Frame = +1 Query: 259 STKMKVEDVQLSMDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQIV 438 ST +K + +L ++ IGKGS G V A+K I + E + I Sbjct: 25 STNLKADPEEL----FTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQ 80 Query: 439 QELKINQATQSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQ 618 QE+ + SP++ + S+ + +++++EY+ GS D+++ + E +A + ++ Sbjct: 81 QEITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEP-GPLDETQIATILRE 139 Query: 619 VLEGLLYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYM 798 +L+GL YLH E+ IHRDIK +N+L++ GEVK+ DFGV+ L + +R+TFVGT +M Sbjct: 140 ILKGLDYLHSEKK-IHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWM 198 Query: 799 APERISGSSYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAP 978 APE I S+YD K+D+WSLG+ +E A G PP E L ++L I PP+ Sbjct: 199 APEVIKQSAYDSKADIWSLGITAIELARGE----PPHSE--LHPMKVLFLIPKNNPPTLE 252 Query: 979 ADQFSPEFCSFISSCIQKDPAERKSASELLNHAFIKKFEDKDLDLRILVE 1128 + +S F+ +C+ K+P+ R +A ELL H FI + K L L++ Sbjct: 253 GN-YSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELID 301
>P97820:M4K4_MOUSE Mitogen-activated protein kinase kinase kinase kinase 4 - Mus| musculus (Mouse) Length = 1233 Score = 153 bits (387), Expect = 1e-36 Identities = 96/274 (35%), Positives = 155/274 (56%), Gaps = 14/274 (5%) Frame = +1 Query: 307 EMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQIVQELK-INQATQSPHIV 483 E+++V+G G+ G V RH V T A + M++ E ++I E+ + + + +I Sbjct: 26 ELVEVVGNGTYGQVYKGRH--VKTVTAAIKV-MDVTEDEEEEITLEINMLKKYSHHRNIA 82 Query: 484 LCHQSFY------HNGVIYLVLEYMDRGSLADIIKQVK--TILEPYLAVLCKQVLEGLLY 639 + +F H+ ++LV+E+ GS+ D++K K T+ E ++A + +++L GL + Sbjct: 83 TYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGLAH 142 Query: 640 LHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERIS- 816 LH HVIHRDIK N+L+ EVK+ DFGVSA L ++G+R+TF+GT +MAPE I+ Sbjct: 143 LHIH-HVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIAC 201 Query: 817 ----GSSYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAPAD 984 ++YDY+SD+WS G+ +E A G P + L I PPP + Sbjct: 202 DENPDATYDYRSDLWSCGITAIEMAEGGPPLCD------MHPMRALFLIPRNPPPRLKSK 255 Query: 985 QFSPEFCSFISSCIQKDPAERKSASELLNHAFIK 1086 ++S +F SFI C+ K+ +R S +LL H FI+ Sbjct: 256 KWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIR 289
>Q6P9R2:OXSR1_MOUSE Serine/threonine-protein kinase OSR1 - Mus musculus (Mouse)| Length = 527 Score = 152 bits (384), Expect = 3e-36 Identities = 101/296 (34%), Positives = 155/296 (52%), Gaps = 24/296 (8%) Frame = +1 Query: 289 LSMDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQIVQELKINQATQ 468 ++ DD E+ +VIG G+ VVQ A+K I + ++ ++++E++ Sbjct: 12 INRDDYELQEVIGSGATAVVQAAYCAPKKERVAIKRINLEKCQTSMDELLKEIQAMSQCH 71 Query: 469 SPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKT--------ILEPYLAVLCKQVL 624 P+IV + SF ++LV++ + GS+ DIIK + + EP +A + ++VL Sbjct: 72 HPNIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDEPTIATILREVL 131 Query: 625 EGLLYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASS-----IGQRDTFVGTY 789 EGL YLH IHRD+K N+L+ G V+I DFGVSA LA+ R TFVGT Sbjct: 132 EGLEYLHKNGQ-IHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGTP 190 Query: 790 NYMAPERISG-SSYDYKSDVWSLGLVILECAIGRFPY--TPPEGEGWLSFYELLEAIVDQ 960 +MAPE + YD+K+D+WS G+ +E A G PY PP ++L + Sbjct: 191 CWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPP--------MKVLMLTLQN 242 Query: 961 PPPSAPA--------DQFSPEFCSFISSCIQKDPAERKSASELLNHAFIKKFEDKD 1104 PPS ++ F IS C+QKDP +R +A+ELL H F +K ++K+ Sbjct: 243 DPPSLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTAAELLRHKFFQKAKNKE 298
>Q9H2G2:SLK_HUMAN STE20-like serine/threonine-protein kinase - Homo sapiens (Human)| Length = 1235 Score = 151 bits (382), Expect = 6e-36 Identities = 100/317 (31%), Positives = 166/317 (52%), Gaps = 6/317 (1%) Frame = +1 Query: 298 DDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQIVQELKINQATQSPH 477 D E+I +G G+ G V ++K A K I +E + +V E+ I + P+ Sbjct: 32 DFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMV-EIDILASCDHPN 90 Query: 478 IVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQV-KTILEPYLAVLCKQVLEGLLYLHHER 654 IV +FY+ +++++E+ G++ ++ ++ + + E + V+CKQ L+ L YLH + Sbjct: 91 IVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNYLHDNK 150 Query: 655 HVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERI-----SG 819 +IHRD+K N+L G++K+ DFGVSA +I +RD+F+GT +MAPE + Sbjct: 151 -IIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSKD 209 Query: 820 SSYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAPADQFSPE 999 YDYK+DVWSLG+ ++E A PP E LL+ +PP A ++S Sbjct: 210 RPYDYKADVWSLGITLIEMA----EIEPPHHE-LNPMRVLLKIAKSEPPTLAQPSRWSSN 264 Query: 1000 FCSFISSCIQKDPAERKSASELLNHAFIKKFEDKDLDLRILVESLEQPMNVPE*GLPLGE 1179 F F+ C++K+ R + S+LL H F+ +K + ++ E+ + E G E Sbjct: 265 FKDFLKKCLEKNVDARWTTSQLLQHPFVTVDSNKPI-RELIAEAKAEVTEEVEDGKEEDE 323 Query: 1180 ARLCGDSLPGPPSRRQS 1230 +SLP P S+R S Sbjct: 324 EEETENSLPIPASKRAS 340
>Q9JM52:MINK1_MOUSE Misshapen-like kinase 1 - Mus musculus (Mouse)| Length = 1308 Score = 151 bits (381), Expect = 7e-36 Identities = 93/274 (33%), Positives = 152/274 (55%), Gaps = 14/274 (5%) Frame = +1 Query: 307 EMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQIVQELK-INQATQSPHIV 483 E+++V+G G+ G V RH G A+K M++ E ++I QE+ + + + +I Sbjct: 26 ELVEVVGNGTYGQVYKGRHVKTGQLAAIK--VMDVTEDEEEEIKQEINMLKKYSHHRNIA 83 Query: 484 LCHQSFY------HNGVIYLVLEYMDRGSLADIIKQVK--TILEPYLAVLCKQVLEGLLY 639 + +F ++ ++LV+E+ GS+ D++K K + E +A +C+++L GL + Sbjct: 84 TYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREILRGLAH 143 Query: 640 LHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERIS- 816 LH + VIHRDIK N+L+ EVK+ DFGVSA L ++G+R+TF+GT +MAPE I+ Sbjct: 144 LHAHK-VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIAC 202 Query: 817 ----GSSYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAPAD 984 ++YDY+SD+WSLG+ +E A G P + L I PPP + Sbjct: 203 DENPDATYDYRSDIWSLGITAIEMAEGAPPLCD------MHPMRALFLIPRNPPPRLKSK 256 Query: 985 QFSPEFCSFISSCIQKDPAERKSASELLNHAFIK 1086 ++S +F FI +C+ K R +LL FI+ Sbjct: 257 KWSKKFTDFIDTCLIKTYLSRPPTEQLLKFPFIR 290
>Q8N4C8:MINK1_HUMAN Misshapen-like kinase 1 - Homo sapiens (Human)| Length = 1332 Score = 151 bits (381), Expect = 7e-36 Identities = 93/274 (33%), Positives = 152/274 (55%), Gaps = 14/274 (5%) Frame = +1 Query: 307 EMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQIVQELK-INQATQSPHIV 483 E+++V+G G+ G V RH G A+K M++ E ++I QE+ + + + +I Sbjct: 26 ELVEVVGNGTYGQVYKGRHVKTGQLAAIK--VMDVTEDEEEEIKQEINMLKKYSHHRNIA 83 Query: 484 LCHQSFY------HNGVIYLVLEYMDRGSLADIIKQVK--TILEPYLAVLCKQVLEGLLY 639 + +F ++ ++LV+E+ GS+ D++K K + E +A +C+++L GL + Sbjct: 84 TYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREILRGLAH 143 Query: 640 LHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERIS- 816 LH + VIHRDIK N+L+ EVK+ DFGVSA L ++G+R+TF+GT +MAPE I+ Sbjct: 144 LHAHK-VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIAC 202 Query: 817 ----GSSYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAPAD 984 ++YDY+SD+WSLG+ +E A G P + L I PPP + Sbjct: 203 DENPDATYDYRSDIWSLGITAIEMAEGAPPLCD------MHPMRALFLIPRNPPPRLKSK 256 Query: 985 QFSPEFCSFISSCIQKDPAERKSASELLNHAFIK 1086 ++S +F FI +C+ K R +LL FI+ Sbjct: 257 KWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIR 290
>Q99KH8:STK24_MOUSE Serine/threonine-protein kinase 24 - Mus musculus (Mouse)| Length = 431 Score = 150 bits (380), Expect = 1e-35 Identities = 95/272 (34%), Positives = 153/272 (56%) Frame = +1 Query: 313 IQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQIVQELKINQATQSPHIVLCH 492 ++ IGKGS G V A+K I + E + I QE+ + SP++ + Sbjct: 27 LEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVTKYY 86 Query: 493 QSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLYLHHERHVIHRD 672 S+ + +++++EY+ GS D+++ + E +A + +++L+GL YLH E+ IHRD Sbjct: 87 GSYLKDTKLWIIMEYLGGGSALDLLEP-GPLDEIQIATILREILKGLDYLHSEKK-IHRD 144 Query: 673 IKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISGSSYDYKSDVWS 852 IK +N+L++ GEVK+ DFGV+ L + +R+TFVGT +MAPE I S+YD K+D+WS Sbjct: 145 IKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKADIWS 204 Query: 853 LGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAPADQFSPEFCSFISSCIQK 1032 LG+ +E A G PP E L ++L I PP+ + +S F+ +C+ K Sbjct: 205 LGITAIELAKGE----PPHSE--LHPMKVLFLIPKNNPPTLEGN-YSKPLKEFVEACLNK 257 Query: 1033 DPAERKSASELLNHAFIKKFEDKDLDLRILVE 1128 +P+ R +A ELL H FI + K L L++ Sbjct: 258 EPSFRPTAKELLKHKFIIRNAKKTSYLTELID 289
>Q9VXE5:PAKM_DROME Serine/threonine-protein kinase PAK mbt - Drosophila melanogaster| (Fruit fly) Length = 639 Score = 150 bits (380), Expect = 1e-35 Identities = 93/267 (34%), Positives = 153/267 (57%), Gaps = 3/267 (1%) Frame = +1 Query: 298 DDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQIVQELKINQATQSPH 477 ++L+ IG+GS G V + K G A+K + + Q+ R+ + E+ I + P+ Sbjct: 366 ENLDHFNKIGEGSTGTVCIATDKSTGRQVAVKKMDLRKQQR-RELLFNEVVIMRDYHHPN 424 Query: 478 IVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLYLHHERH 657 IV + SF N +++V+EY++ G+L DI+ + + E +A +CKQ L+ L YLH + Sbjct: 425 IVETYSSFLVNDELWVVMEYLEGGALTDIVTHSR-MDEEQIATVCKQCLKALAYLHSQG- 482 Query: 658 VIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISGSSYDYK 837 VIHRDIK ++L+ G VK++DFG A ++ + +R + VGT +M+PE IS Y + Sbjct: 483 VIHRDIKSDSILLAADGRVKLSDFGFCAQVSQELPKRKSLVGTPYWMSPEVISRLPYGPE 542 Query: 838 SDVWSLGLVILECAIGRFPY--TPPEGEGWLSFYELLEAIVD-QPPPSAPADQFSPEFCS 1008 D+WSLG++++E G P+ PP + + I D QPP A + SP S Sbjct: 543 VDIWSLGIMVIEMVDGEPPFFNEPP--------LQAMRRIRDMQPPNLKNAHKVSPRLQS 594 Query: 1009 FISSCIQKDPAERKSASELLNHAFIKK 1089 F+ + +DPA+R +A+ELL H F+++ Sbjct: 595 FLDRMLVRDPAQRATAAELLAHPFLRQ 621
>O54988:SLK_MOUSE STE20-like serine/threonine-protein kinase - Mus musculus (Mouse)| Length = 1233 Score = 150 bits (379), Expect = 1e-35 Identities = 101/334 (30%), Positives = 174/334 (52%), Gaps = 9/334 (2%) Frame = +1 Query: 256 QSTKMKVEDVQLSMDDLEMIQVIGK---GSGGVVQLVRHKWVGTFYALKGIQMNIQESVR 426 + K + E V+ ++ E ++IG+ G+ G V ++K A K I +E + Sbjct: 15 EKKKKQYEHVKRDLNPEEFWEIIGELGDGAFGKVYKAQNKETNVLAAAKVIDTKSEEELE 74 Query: 427 KQIVQELKINQATQSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQV-KTILEPYLA 603 +V E+ I + P+IV +FY+ +++++E+ G++ ++ ++ + + E + Sbjct: 75 DYMV-EIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQ 133 Query: 604 VLCKQVLEGLLYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVG 783 V+CKQ LE L YLH + +IHRD+K N+L G++K+ DFGVSA +I +RD+F+G Sbjct: 134 VVCKQTLEALNYLHDNK-IIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIG 192 Query: 784 TYNYMAPERI-----SGSSYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEA 948 T +MAPE + YDYK+DVWSLG+ ++E A PP E LL+ Sbjct: 193 TPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMA----EIEPPHHE-LNPMRVLLKI 247 Query: 949 IVDQPPPSAPADQFSPEFCSFISSCIQKDPAERKSASELLNHAFIKKFEDKDLDLRILVE 1128 +PP A ++S F F+ C++K+ R + S+LL H F+ +K + ++ E Sbjct: 248 AKSEPPTLAQPSKWSSNFKDFLRKCLEKNVDARWTTSQLLQHPFVTVDSNKPV-RELIAE 306 Query: 1129 SLEQPMNVPE*GLPLGEARLCGDSLPGPPSRRQS 1230 + + E G E ++LP P ++R S Sbjct: 307 AKAEVTEEVEDGKEEDEEEEAENALPIPANKRAS 340
>Q5R8Z4:PAK6_PONPY Serine/threonine-protein kinase PAK 6 - Pongo pygmaeus (Orangutan)| Length = 681 Score = 149 bits (376), Expect = 3e-35 Identities = 89/255 (34%), Positives = 149/255 (58%), Gaps = 1/255 (0%) Frame = +1 Query: 322 IGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQIVQELKINQATQSPHIVLCHQSF 501 IG+GS G+V L R K G A+K + + Q+ R+ + E+ I + Q ++V ++S+ Sbjct: 413 IGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQR-RELLFNEVVIMRDYQHFNVVEMYKSY 471 Query: 502 YHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLYLHHERHVIHRDIKP 681 +++++E++ G+L DI+ QV+ + E +A +C+ VL+ L YLH + VIHRDIK Sbjct: 472 LVGEELWVLMEFLQGGALTDIVSQVR-LNEEQIATVCEAVLQALAYLHAQG-VIHRDIKS 529 Query: 682 SNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISGSSYDYKSDVWSLGL 861 ++L+ G VK++DFG A ++ + +R + VGT +MAPE IS S Y + D+WSLG+ Sbjct: 530 DSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEVDIWSLGI 589 Query: 862 VILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAP-ADQFSPEFCSFISSCIQKDP 1038 +++E G PY S + ++ + D PPP + + SP F+ + +DP Sbjct: 590 MVIEMVDGEPPYFSD------SPVQAMKRLRDSPPPKLKNSHKVSPVLRDFLERMLVRDP 643 Query: 1039 AERKSASELLNHAFI 1083 ER +A ELL+H F+ Sbjct: 644 QERATAQELLDHPFL 658
>Q9NQU5:PAK6_HUMAN Serine/threonine-protein kinase PAK 6 - Homo sapiens (Human)| Length = 681 Score = 149 bits (376), Expect = 3e-35 Identities = 89/255 (34%), Positives = 149/255 (58%), Gaps = 1/255 (0%) Frame = +1 Query: 322 IGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQIVQELKINQATQSPHIVLCHQSF 501 IG+GS G+V L R K G A+K + + Q+ R+ + E+ I + Q ++V ++S+ Sbjct: 413 IGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQR-RELLFNEVVIMRDYQHFNVVEMYKSY 471 Query: 502 YHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLYLHHERHVIHRDIKP 681 +++++E++ G+L DI+ QV+ + E +A +C+ VL+ L YLH + VIHRDIK Sbjct: 472 LVGEELWVLMEFLQGGALTDIVSQVR-LNEEQIATVCEAVLQALAYLHAQG-VIHRDIKS 529 Query: 682 SNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISGSSYDYKSDVWSLGL 861 ++L+ G VK++DFG A ++ + +R + VGT +MAPE IS S Y + D+WSLG+ Sbjct: 530 DSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEVDIWSLGI 589 Query: 862 VILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAP-ADQFSPEFCSFISSCIQKDP 1038 +++E G PY S + ++ + D PPP + + SP F+ + +DP Sbjct: 590 MVIEMVDGEPPYFSD------SPVQAMKRLRDSPPPKLKNSHKVSPVLRDFLERMLVRDP 643 Query: 1039 AERKSASELLNHAFI 1083 ER +A ELL+H F+ Sbjct: 644 QERATAQELLDHPFL 658
>Q5R495:OXSR1_PONPY Serine/threonine-protein kinase OSR1 - Pongo pygmaeus (Orangutan)| Length = 527 Score = 149 bits (376), Expect = 3e-35 Identities = 100/296 (33%), Positives = 154/296 (52%), Gaps = 24/296 (8%) Frame = +1 Query: 289 LSMDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQIVQELKINQATQ 468 ++ DD E+ +VIG G+ VVQ A+K I + ++ ++++E++ Sbjct: 12 INRDDYELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAMSQCH 71 Query: 469 SPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKT--------ILEPYLAVLCKQVL 624 P+IV + SF ++LV++ + GS+ DIIK + + E +A + ++VL Sbjct: 72 HPNIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILREVL 131 Query: 625 EGLLYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASS-----IGQRDTFVGTY 789 EGL YLH IHRD+K N+L+ G V+I DFGVSA LA+ R TFVGT Sbjct: 132 EGLEYLHKNGQ-IHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGTP 190 Query: 790 NYMAPERISG-SSYDYKSDVWSLGLVILECAIGRFPY--TPPEGEGWLSFYELLEAIVDQ 960 +MAPE + YD+K+D+WS G+ +E A G PY PP ++L + Sbjct: 191 CWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPP--------MKVLMLTLQN 242 Query: 961 PPPSAPA--------DQFSPEFCSFISSCIQKDPAERKSASELLNHAFIKKFEDKD 1104 PPS ++ F IS C+QKDP +R +A+ELL H F +K ++K+ Sbjct: 243 DPPSLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTAAELLRHKFFQKAKNKE 298
>Q863I2:OXSR1_PIG Serine/threonine-protein kinase OSR1 - Sus scrofa (Pig)| Length = 529 Score = 149 bits (376), Expect = 3e-35 Identities = 100/296 (33%), Positives = 154/296 (52%), Gaps = 24/296 (8%) Frame = +1 Query: 289 LSMDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQIVQELKINQATQ 468 ++ DD E+ +VIG G+ VVQ A+K I + ++ ++++E++ Sbjct: 12 INKDDYELQEVIGSGATAVVQAAYCTPKKEKVAIKRINLEKCQTSMDELLKEIQAMSQCH 71 Query: 469 SPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKT--------ILEPYLAVLCKQVL 624 P+IV + SF ++LV++ + GS+ DIIK + + E +A + ++VL Sbjct: 72 HPNIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDEATIATILREVL 131 Query: 625 EGLLYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASS-----IGQRDTFVGTY 789 EGL YLH IHRD+K N+L+ G V+I DFGVSA LA+ R TFVGT Sbjct: 132 EGLEYLHKNGQ-IHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGTP 190 Query: 790 NYMAPERISG-SSYDYKSDVWSLGLVILECAIGRFPY--TPPEGEGWLSFYELLEAIVDQ 960 +MAPE + YD+K+D+WS G+ +E A G PY PP ++L + Sbjct: 191 CWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPP--------MKVLMLTLQN 242 Query: 961 PPPSAPA--------DQFSPEFCSFISSCIQKDPAERKSASELLNHAFIKKFEDKD 1104 PPS ++ F IS C+QKDP +R +A+ELL H F +K ++K+ Sbjct: 243 DPPSLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTAAELLRHKFFQKAKNKE 298
>O95747:OXSR1_HUMAN Serine/threonine-protein kinase OSR1 - Homo sapiens (Human)| Length = 527 Score = 149 bits (376), Expect = 3e-35 Identities = 100/296 (33%), Positives = 154/296 (52%), Gaps = 24/296 (8%) Frame = +1 Query: 289 LSMDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQIVQELKINQATQ 468 ++ DD E+ +VIG G+ VVQ A+K I + ++ ++++E++ Sbjct: 12 INRDDYELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAMSQCH 71 Query: 469 SPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKT--------ILEPYLAVLCKQVL 624 P+IV + SF ++LV++ + GS+ DIIK + + E +A + ++VL Sbjct: 72 HPNIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILREVL 131 Query: 625 EGLLYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASS-----IGQRDTFVGTY 789 EGL YLH IHRD+K N+L+ G V+I DFGVSA LA+ R TFVGT Sbjct: 132 EGLEYLHKNGQ-IHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGTP 190 Query: 790 NYMAPERISG-SSYDYKSDVWSLGLVILECAIGRFPY--TPPEGEGWLSFYELLEAIVDQ 960 +MAPE + YD+K+D+WS G+ +E A G PY PP ++L + Sbjct: 191 CWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPP--------MKVLMLTLQN 242 Query: 961 PPPSAPA--------DQFSPEFCSFISSCIQKDPAERKSASELLNHAFIKKFEDKD 1104 PPS ++ F IS C+QKDP +R +A+ELL H F +K ++K+ Sbjct: 243 DPPSLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTAAELLRHKFFQKAKNKE 298
>O55092:SLK_CAVPO STE20-like serine/threonine-protein kinase - Cavia porcellus (Guinea| pig) Length = 1231 Score = 149 bits (375), Expect = 4e-35 Identities = 101/334 (30%), Positives = 173/334 (51%), Gaps = 9/334 (2%) Frame = +1 Query: 256 QSTKMKVEDVQLSMDDLEMIQVIGK---GSGGVVQLVRHKWVGTFYALKGIQMNIQESVR 426 + K + E V+ ++ E + IG+ G+ G V ++K A K I +E + Sbjct: 15 EKKKKQYEHVKRDLNPEEFWETIGELGDGAFGKVYKAQNKETNVLAAAKVIDTKSEEELE 74 Query: 427 KQIVQELKINQATQSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQV-KTILEPYLA 603 +V E+ I + P+IV +FY+ +++++E+ G++ ++ ++ + + E + Sbjct: 75 DYMV-EIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQ 133 Query: 604 VLCKQVLEGLLYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVG 783 V+CKQ LE L YLH + +IHRD+K N+L G++K+ DFGVSA +I +RD+F+G Sbjct: 134 VVCKQTLEALNYLHDNK-IIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIG 192 Query: 784 TYNYMAPERI-----SGSSYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEA 948 T +MAPE + YDYK+DVWSLG+ ++E A PP E LL+ Sbjct: 193 TPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMA----EIEPPHHE-LNPMRVLLKI 247 Query: 949 IVDQPPPSAPADQFSPEFCSFISSCIQKDPAERKSASELLNHAFIKKFEDKDLDLRILVE 1128 +PP A ++S F F+ C++K+ R + S+LL H F+ +K + ++ E Sbjct: 248 AKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVTIDSNKPI-RELIAE 306 Query: 1129 SLEQPMNVPE*GLPLGEARLCGDSLPGPPSRRQS 1230 + + E G + +SLP P ++R S Sbjct: 307 AKAEVTEEVEDGKEEDDDEEIENSLPIPTNKRAS 340
>O14305:SID1_SCHPO Serine/threonine-protein kinase sid1 - Schizosaccharomyces pombe| (Fission yeast) Length = 471 Score = 148 bits (373), Expect = 6e-35 Identities = 93/267 (34%), Positives = 148/267 (55%), Gaps = 1/267 (0%) Frame = +1 Query: 289 LSMDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQIVQELKINQATQ 468 L+ + +++ +G GS GVV R G A+K I + I QE+ + Sbjct: 4 LNANSYTLLRKLGSGSFGVVWKARENVSGDIIAIKQIDLETGIDDITDIEQEVFMLSNCN 63 Query: 469 SPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLYLHH 648 S +++ + F +++++E+MD GS++ ++K + + E ++++ ++VL GL YLH Sbjct: 64 SSNVIQYYGCFVDGYTLWILMEHMDGGSVSGLLKMGR-LNEQVISIILREVLYGLNYLHG 122 Query: 649 ERHVIHRDIKPSNLLVNHK-GEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISGSS 825 + IHRDIK +N+L++ G VK+ DFGV+A L+++ +R TFVGT +MAPE I +S Sbjct: 123 QNK-IHRDIKAANILLSSSTGNVKLADFGVAAQLSNAASRRHTFVGTPFWMAPEVIQQTS 181 Query: 826 YDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAPADQFSPEFC 1005 Y +D+WSLG+ +E A G PP + ++ I PP D FSP F Sbjct: 182 YGLAADIWSLGITAIEMANG----IPPRAT--MHPMRVIFEIPQSEPPKLD-DHFSPTFR 234 Query: 1006 SFISSCIQKDPAERKSASELLNHAFIK 1086 F+S C+ +P R SA ELL H FIK Sbjct: 235 DFVSCCLDLNPNMRWSAKELLQHPFIK 261
>O08815:SLK_RAT STE20-like serine/threonine-protein kinase - Rattus norvegicus (Rat)| Length = 1206 Score = 147 bits (372), Expect = 8e-35 Identities = 100/334 (29%), Positives = 173/334 (51%), Gaps = 9/334 (2%) Frame = +1 Query: 256 QSTKMKVEDVQLSMDDLEMIQVIGK---GSGGVVQLVRHKWVGTFYALKGIQMNIQESVR 426 + K + E V+ ++ E ++IG+ G+ G V ++K A K I +E + Sbjct: 15 EKKKKQYEHVKRDLNPEEFWEIIGELGDGAFGKVYKAQNKETNVLAAAKVIDTKSEEELE 74 Query: 427 KQIVQELKINQATQSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQV-KTILEPYLA 603 +V E+ I + P+IV +FY+ +++++E+ G++ ++ ++ + + E + Sbjct: 75 DYMV-EIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQ 133 Query: 604 VLCKQVLEGLLYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVG 783 V+CKQ LE L YLH + +IHRD+K N+L G++K+ DFGVSA +I +RD+F+G Sbjct: 134 VVCKQTLEALNYLHDNK-IIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIG 192 Query: 784 TYNYMAPERI-----SGSSYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEA 948 T +MAPE + YDYK+DVWSLG+ ++E A PP E LL+ Sbjct: 193 TPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMA----EIEPPHHE-LNPMRVLLKI 247 Query: 949 IVDQPPPSAPADQFSPEFCSFISSCIQKDPAERKSASELLNHAFIKKFEDKDLDLRILVE 1128 +PP A ++S F F+ C++K+ R + S+LL H F+ +K + ++ E Sbjct: 248 AKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVTVDSNKPV-RELIAE 306 Query: 1129 SLEQPMNVPE*GLPLGEARLCGDSLPGPPSRRQS 1230 + + E G + +LP P ++R S Sbjct: 307 AKAEVTEEVEDGKEEDDDDETESALPIPANKRAS 340
>P46599:STE7_CANAL Serine/threonine-protein kinase STE7 homolog - Candida albicans| (Yeast) Length = 589 Score = 145 bits (367), Expect = 3e-34 Identities = 106/332 (31%), Positives = 159/332 (47%), Gaps = 61/332 (18%) Frame = +1 Query: 256 QSTKMKVEDVQLSMDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQI 435 QS ++L+ DL ++ +G G+ G V + H A K I ++ + ++ QI Sbjct: 233 QSPIATTSSLKLNNKDLLTLKQLGSGNSGSVSKILHIPTQKTMAKKIIHIDSKSVIQTQI 292 Query: 436 VQELKINQATQSPHIVLCHQS-FYHNGVIYLVLEYMDRGSLADII-----KQVKTILEPY 597 ++EL+I SP+I+ + + +N I + +EY + GSL I+ KQ T + Sbjct: 293 IRELRILHECHSPYIIEFYGACLNNNNTIVICMEYCNCGSLDKILPLCENKQFPTFV--- 349 Query: 598 LAVLCKQVLEGLLYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTF 777 L L +L GL YL+ +IHRDIKP+N+L+ HKGE K+ DFGVS L +S+ DTF Sbjct: 350 LKKLSFAILSGLTYLYTTHKIIHRDIKPNNVLMTHKGEFKLCDFGVSRELTNSLAMADTF 409 Query: 778 VGTYNYMAPERISGSSYDYKSDVWSLGLVILECAIG------------------------ 885 VGT YM+PERI G Y KSDVWS GL+++E A G Sbjct: 410 VGTSMYMSPERIQGLDYGVKSDVWSTGLMLIELASGVPVWSEDDNNNDDDEDDEDDAYVR 469 Query: 886 ---------------RFPYTPPEGEGWLSF------YELLEAIVDQPPPS---------- 972 R +G G+ S+ +LL+ IV++ P+ Sbjct: 470 QGSIAAERNGQNSPSRSRKNKQKGNGYNSYNGPEGILDLLQRIVNEDAPTLTNKINPVTK 529 Query: 973 APADQFSPEFCSFISSCIQKDPAERKSASELL 1068 P D++ C FI C+ KD + RK+ +LL Sbjct: 530 LPYDKY---LCQFIDLCLIKDDSVRKTPWQLL 558
>Q29502:PAK2_RABIT Serine/threonine-protein kinase PAK 2 - Oryctolagus cuniculus| (Rabbit) Length = 524 Score = 145 bits (365), Expect = 5e-34 Identities = 93/296 (31%), Positives = 160/296 (54%), Gaps = 11/296 (3%) Frame = +1 Query: 232 SEENGDEHQSTKMKVEDVQLSMDDLEMI----------QVIGKGSGGVVQLVRHKWVGTF 381 ++ + + + TKM E++ + + I + IG+G+ G V +G Sbjct: 215 AKSSDKQKKKTKMTDEEIMEKLRTIVSIGDPKKKYTRYEKIGQGASGTVFTATDVALGQE 274 Query: 382 YALKGIQMNIQESVRKQ-IVQELKINQATQSPHIVLCHQSFYHNGVIYLVLEYMDRGSLA 558 A+K Q+N+Q+ +K+ I+ E+ + + ++P+IV S+ +++V+EY+ GSL Sbjct: 275 VAIK--QINLQKQPKKELIINEILVMKELKNPNIVNFLDSYLVGDELFVVMEYLAGGSLT 332 Query: 559 DIIKQVKTILEPYLAVLCKQVLEGLLYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVS 738 D++ + + E +A +C++ L+ L +LH + VIHRDIK N+L+ +G VK+TDFG Sbjct: 333 DVVTET-CMDEAQIAAVCRECLQALEFLHANQ-VIHRDIKSDNVLLGMEGSVKLTDFGFC 390 Query: 739 AVLASSIGQRDTFVGTYNYMAPERISGSSYDYKSDVWSLGLVILECAIGRFPYTPPEGEG 918 A + +R T VGT +MAPE ++ +Y K D+WSLG++ +E G PY E Sbjct: 391 AQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYL---NEN 447 Query: 919 WLSFYELLEAIVDQPPPSAPADQFSPEFCSFISSCIQKDPAERKSASELLNHAFIK 1086 L L+ + P ++ SP F F++ C++ D +R SA ELL H F+K Sbjct: 448 PLRALYLI--ATNGTPELQNPEKLSPIFRDFLNRCLEMDVEKRGSAKELLQHPFLK 501
>Q7RZD3:STE20_NEUCR Serine/threonine-protein kinase ste-20 - Neurospora crassa| Length = 954 Score = 144 bits (364), Expect = 7e-34 Identities = 89/262 (33%), Positives = 141/262 (53%), Gaps = 3/262 (1%) Frame = +1 Query: 322 IGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQ-IVQELKINQATQSPHIVLCHQS 498 IG+G+ G V + A+K QMN+++ +K I+ E+ + + + P+IV S Sbjct: 680 IGQGASGGVYTGHERGSNRLVAIK--QMNLEQQPKKDLIINEILVMKESSHPNIVNFIDS 737 Query: 499 FYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLYLHHERHVIHRDIK 678 + G +++V+EYM+ GSL D++ + E +A +C++ L GL +LH + VIHRDIK Sbjct: 738 YLCAGELWVVMEYMEGGSLTDVVT-FNIMTEGQIASVCRETLRGLQHLH-SKGVIHRDIK 795 Query: 679 PSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISGSSYDYKSDVWSLG 858 N+L++ +G +K+TDFG A + + +R T VGT +MAPE ++ Y K D+WSLG Sbjct: 796 SDNILLSMEGNIKLTDFGFCATINEAQSKRTTMVGTPYWMAPEVVTRKEYGRKVDIWSLG 855 Query: 859 LVILECAIGRFPY--TPPEGEGWLSFYELLEAIVDQPPPSAPADQFSPEFCSFISSCIQK 1032 ++ +E G PY P WL + P SP F F+ ++ Sbjct: 856 IMAIEMIEGEPPYLTESPLRALWL-------IATNGTPHIKDEQSLSPVFRDFLYFALKV 908 Query: 1033 DPAERKSASELLNHAFIKKFED 1098 DP +R SA +LL H F+ K D Sbjct: 909 DPEKRASAHDLLRHDFMNKCVD 930
>Q3ULB5:PAK6_MOUSE Serine/threonine-protein kinase PAK 6 - Mus musculus (Mouse)| Length = 682 Score = 144 bits (364), Expect = 7e-34 Identities = 88/255 (34%), Positives = 148/255 (58%), Gaps = 1/255 (0%) Frame = +1 Query: 322 IGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQIVQELKINQATQSPHIVLCHQSF 501 IG+GS G+V L R K G A+K + + Q+ R+ + E+ I + Q ++V ++S+ Sbjct: 414 IGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQR-RELLFNEVVIMRDYQHLNVVEMYKSY 472 Query: 502 YHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLYLHHERHVIHRDIKP 681 +++++E++ G+L DII QV+ + E +A +C+ VL+ L YLH + VIHRDIK Sbjct: 473 LVGEELWVLMEFLQGGALTDIISQVR-LNEEQIATVCEAVLQALAYLHAQG-VIHRDIKS 530 Query: 682 SNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISGSSYDYKSDVWSLGL 861 ++L+ G VK++DFG A ++ + +R + VGT +MAPE IS S Y + D+WSLG+ Sbjct: 531 DSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEVDIWSLGI 590 Query: 862 VILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAP-ADQFSPEFCSFISSCIQKDP 1038 +++E G PY S + ++ + D PP + + SP F+ + ++P Sbjct: 591 MVIEMVDGEPPYFSD------SPVQAMKRLRDSAPPKLKNSYKVSPVLRDFLDRMLVREP 644 Query: 1039 AERKSASELLNHAFI 1083 ER +A ELL+H F+ Sbjct: 645 QERATAQELLDHPFL 659
>Q13177:PAK2_HUMAN Serine/threonine-protein kinase PAK 2 - Homo sapiens (Human)| Length = 524 Score = 144 bits (364), Expect = 7e-34 Identities = 93/290 (32%), Positives = 157/290 (54%), Gaps = 11/290 (3%) Frame = +1 Query: 250 EHQSTKMKVEDVQLSMDDLEMI----------QVIGKGSGGVVQLVRHKWVGTFYALKGI 399 + + TKM E++ + + I + IG+G+ G V +G A+K Sbjct: 221 QKKKTKMTDEEIMEKLRTIVSIGDPKKKYTRYEKIGQGASGTVFTATDVALGQEVAIK-- 278 Query: 400 QMNIQESVRKQ-IVQELKINQATQSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQV 576 Q+N+Q+ +K+ I+ E+ + + ++P+IV S+ +++V+EY+ GSL D++ + Sbjct: 279 QINLQKQPKKELIINEILVMKELKNPNIVNFLDSYLVGDELFVVMEYLAGGSLTDVVTET 338 Query: 577 KTILEPYLAVLCKQVLEGLLYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASS 756 + E +A +C++ L+ L +LH + VIHRDIK N+L+ +G VK+TDFG A + Sbjct: 339 -CMDEAQIAAVCRECLQALEFLHANQ-VIHRDIKSDNVLLGMEGSVKLTDFGFCAQITPE 396 Query: 757 IGQRDTFVGTYNYMAPERISGSSYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYE 936 +R T VGT +MAPE ++ +Y K D+WSLG++ +E G PY E L Sbjct: 397 QSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYL---NENPLRALY 453 Query: 937 LLEAIVDQPPPSAPADQFSPEFCSFISSCIQKDPAERKSASELLNHAFIK 1086 L+ + P ++ SP F F++ C++ D +R SA ELL H F+K Sbjct: 454 LI--ATNGTPELQNPEKLSPIFRDFLNRCLEMDVEKRGSAKELLQHPFLK 501
>Q64303:PAK2_RAT Serine/threonine-protein kinase PAK 2 - Rattus norvegicus (Rat)| Length = 524 Score = 144 bits (363), Expect = 9e-34 Identities = 88/256 (34%), Positives = 145/256 (56%), Gaps = 1/256 (0%) Frame = +1 Query: 322 IGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQ-IVQELKINQATQSPHIVLCHQS 498 IG+G+ G V +G A+K Q+N+Q+ +K+ I+ E+ + + ++P+IV S Sbjct: 255 IGQGASGTVFTATDVALGQEVAIK--QINLQKQPKKELIINEILVMKELKNPNIVNFLDS 312 Query: 499 FYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLYLHHERHVIHRDIK 678 + +++V+EY+ GSL D++ + + E +A +C++ L+ L +LH + VIHRDIK Sbjct: 313 YLVGDELFVVMEYLAGGSLTDVVTET-CMDEAQIAAVCRECLQALEFLHANQ-VIHRDIK 370 Query: 679 PSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISGSSYDYKSDVWSLG 858 N+L+ +G VK+TDFG A + +R T VGT +MAPE ++ +Y K D+WSLG Sbjct: 371 SDNVLLGMEGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLG 430 Query: 859 LVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAPADQFSPEFCSFISSCIQKDP 1038 ++ +E G PY E L L+ + P ++ SP F F++ C++ D Sbjct: 431 IMAIEMVEGEPPYL---NENPLRALYLI--ATNGTPELQNPEKLSPIFRDFLNRCLEMDV 485 Query: 1039 AERKSASELLNHAFIK 1086 +R SA ELL H F+K Sbjct: 486 EKRGSAKELLQHPFLK 501
>Q8CIN4:PAK2_MOUSE Serine/threonine-protein kinase PAK 2 - Mus musculus (Mouse)| Length = 524 Score = 144 bits (363), Expect = 9e-34 Identities = 88/256 (34%), Positives = 145/256 (56%), Gaps = 1/256 (0%) Frame = +1 Query: 322 IGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQ-IVQELKINQATQSPHIVLCHQS 498 IG+G+ G V +G A+K Q+N+Q+ +K+ I+ E+ + + ++P+IV S Sbjct: 255 IGQGASGTVFTATDVALGQEVAIK--QINLQKQPKKELIINEILVMKELKNPNIVNFLDS 312 Query: 499 FYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLYLHHERHVIHRDIK 678 + +++V+EY+ GSL D++ + + E +A +C++ L+ L +LH + VIHRDIK Sbjct: 313 YLVGDELFVVMEYLAGGSLTDVVTET-CMDEAQIAAVCRECLQALEFLHANQ-VIHRDIK 370 Query: 679 PSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISGSSYDYKSDVWSLG 858 N+L+ +G VK+TDFG A + +R T VGT +MAPE ++ +Y K D+WSLG Sbjct: 371 SDNVLLGMEGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLG 430 Query: 859 LVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAPADQFSPEFCSFISSCIQKDP 1038 ++ +E G PY E L L+ + P ++ SP F F++ C++ D Sbjct: 431 IMAIEMVEGEPPYL---NENPLRALYLI--ATNGTPELQNPEKLSPIFRDFLNRCLEMDV 485 Query: 1039 AERKSASELLNHAFIK 1086 +R SA ELL H F+K Sbjct: 486 EKRGSAKELLQHPFLK 501
>Q23356:MIG15_CAEEL Serine/threonine-protein kinase mig-15 - Caenorhabditis elegans| Length = 1096 Score = 144 bits (363), Expect = 9e-34 Identities = 98/280 (35%), Positives = 151/280 (53%), Gaps = 19/280 (6%) Frame = +1 Query: 307 EMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQIVQELKINQATQSPH--- 477 E+I+V+G G+ G V RH A+K MNI E +I +L+IN + H Sbjct: 22 ELIEVVGNGTYGQVYKGRHVKTAQLAAIK--IMNINEDEEDEI--KLEINMLKKHSHHRN 77 Query: 478 --------IVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVK--TILEPYLAVLCKQVLE 627 I S + ++LV+E+ GS+ D++K K ++ E ++A +C+++L Sbjct: 78 VATYYGAFIKKLPSSTGKHDQLWLVMEFCGSGSITDLVKNTKGGSLKEEWIAYICREILR 137 Query: 628 GLLYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPE 807 GL +LH + VIHRDIK N+L+ EVK+ DFGVSA L ++G+R+TF+GT +MAPE Sbjct: 138 GLYHLHQSK-VIHRDIKGQNVLLTDSAEVKLVDFGVSAQLDKTVGRRNTFIGTPYWMAPE 196 Query: 808 RIS-----GSSYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPS 972 I+ ++YD +SD+WSLG+ LE A G P + L I PPP Sbjct: 197 VIACDESPEATYDSRSDLWSLGITALEMAEGHPPLCD------MHPMRALFLIPRNPPPK 250 Query: 973 APAD-QFSPEFCSFISSCIQKDPAERKSASELLNHAFIKK 1089 + +++ +F +FI + + KD +R LL H FIK+ Sbjct: 251 LKRNKKWTKKFETFIETVLVKDYHQRPYTGALLRHPFIKE 290
>Q6FN53:STE20_CANGA Serine/threonine-protein kinase STE20 - Candida glabrata (Yeast)| (Torulopsis glabrata) Length = 915 Score = 143 bits (361), Expect = 2e-33 Identities = 89/273 (32%), Positives = 150/273 (54%), Gaps = 4/273 (1%) Frame = +1 Query: 322 IGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQIV-QELKINQATQSPHIVLCHQS 498 IG+G+ G V + A+K QMN+++ +K+++ E+ + + ++ +IV S Sbjct: 626 IGQGASGGVYIAHDTESEDSVAIK--QMNLEKQPKKELILNEILVMRESKHSNIVNFIDS 683 Query: 499 FYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLYLHHERHVIHRDIK 678 + G +++V+EYM+ GSL D++ + E + +C++ L+GL +LH + V+HRDIK Sbjct: 684 YLAKGDLWIVMEYMEGGSLTDVVTHC-LLSEGQIGAVCRETLKGLQFLH-SKGVLHRDIK 741 Query: 679 PSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISGSSYDYKSDVWSLG 858 N+L++ KG +K+TDFG A + + +R T VGT +MAPE +S Y K D+WSLG Sbjct: 742 SDNILLSLKGNIKLTDFGFCAQINENNLKRTTMVGTPYWMAPEVVSRKEYGPKVDIWSLG 801 Query: 859 LVILECAIGRFPY---TPPEGEGWLSFYELLEAIVDQPPPSAPADQFSPEFCSFISSCIQ 1029 ++I+E G PY TP L + P + S F+ C++ Sbjct: 802 IMIIEMIEGEPPYLNETP--------LRALYLIATNGTPKLKEPEALSDTLTKFLDWCLK 853 Query: 1030 KDPAERKSASELLNHAFIKKFEDKDLDLRILVE 1128 DP+ER +A+ELL+ FI + + + L LV+ Sbjct: 854 VDPSERATATELLDDPFITEIAEDNSSLSPLVK 886
>Q92212:STE20_CANAL Serine/threonine-protein kinase CST20 - Candida albicans (Yeast)| Length = 1228 Score = 143 bits (360), Expect = 2e-33 Identities = 96/266 (36%), Positives = 146/266 (54%), Gaps = 7/266 (2%) Frame = +1 Query: 322 IGKGSGGVVQL---VRHKWVGTFYALKGIQMNIQESVRKQ-IVQELKINQATQSPHIVLC 489 IG+G+ G V L VR K A+K QMN+++ +K+ I+ E+ + + + P+IV Sbjct: 957 IGQGASGGVFLAHDVRDK--SNIVAIK--QMNLEQQPKKELIINEILVMKGSSHPNIVNF 1012 Query: 490 HQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLYLHHERHVIHR 669 S+ G +++++EYM+ GSL DI+ + E + V+C++ L+GL +LH + VIHR Sbjct: 1013 IDSYLLKGDLWVIMEYMEGGSLTDIVTH-SVMTEGQIGVVCRETLKGLKFLH-SKGVIHR 1070 Query: 670 DIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISGSSYDYKSDVW 849 DIK N+L+N G +KITDFG A + +R T VGT +MAPE +S Y K DVW Sbjct: 1071 DIKSDNILLNMDGNIKITDFGFCAQINEINSKRITMVGTPYWMAPEIVSRKEYGPKVDVW 1130 Query: 850 SLGLVILECAIGRFPY---TPPEGEGWLSFYELLEAIVDQPPPSAPADQFSPEFCSFISS 1020 SLG++I+E G PY TP L + P + S + F++ Sbjct: 1131 SLGIMIIEMLEGEPPYLNETP--------LRALYLIATNGTPKLKDPESLSYDIRKFLAW 1182 Query: 1021 CIQKDPAERKSASELLNHAFIKKFED 1098 C+Q D +R A ELL+ FI + +D Sbjct: 1183 CLQVDFNKRADADELLHDNFITECDD 1208
>O59790:ARK1_SCHPO Serine/threonine-protein kinase ark1 - Schizosaccharomyces pombe| (Fission yeast) Length = 355 Score = 143 bits (360), Expect = 2e-33 Identities = 95/320 (29%), Positives = 160/320 (50%), Gaps = 23/320 (7%) Frame = +1 Query: 208 NQRGLQLISEENGDEHQSTK--------MKVEDV-------------QLSMDDLEMIQVI 324 NQR + +S NG E++ T K+E+ + + E+ + + Sbjct: 36 NQRQVNNVSLANGKENKRTSNSKFNSSLRKIEEPIAGVPSSAGPQWREFHIGMFEIGKPL 95 Query: 325 GKGSGGVVQLVRHKWVGTFYALKGIQMN--IQESVRKQIVQELKINQATQSPHIVLCHQS 498 GKG G V L + K G ALK + + +Q + KQ+ +E++I + +I+ + Sbjct: 96 GKGKFGRVYLAKEKKTGFIVALKTLHKSELVQSKIEKQVRREIEIQSNLRHKNILRLYGH 155 Query: 499 FYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLYLHHERHVIHRDIK 678 F+ IYL+LE+ RG L +++ K E + Q+ L YLH ++HVIHRDIK Sbjct: 156 FHDEKRIYLILEFAGRGELYQHLRRAKRFSEEVASKYIFQMANALSYLH-KKHVIHRDIK 214 Query: 679 PSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISGSSYDYKSDVWSLG 858 P N+L+ GE+K++DFG S S+ +R T GT +Y+ PE + G + K D+WSLG Sbjct: 215 PENILLGIDGEIKLSDFGWSVHAPSN--RRTTLCGTLDYLPPEMVEGKEHTEKVDLWSLG 272 Query: 859 LVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAPADQFSPEFCSFISSCIQKDP 1038 ++ E +G P+ G + Y+ + + + P P P+ IS +Q +P Sbjct: 273 VLTYEFLVGAPPFEDMSGHS--ATYKRIAKVDLKIPSFVP-----PDARDLISRLLQHNP 325 Query: 1039 AERKSASELLNHAFIKKFED 1098 +R S +++ H +I K++D Sbjct: 326 EKRMSLEQVMRHPWIVKYKD 345
>Q2ULU3:STE20_ASPOR Serine/threonine-protein kinase ste20 - Aspergillus oryzae| Length = 848 Score = 142 bits (359), Expect = 3e-33 Identities = 86/255 (33%), Positives = 141/255 (55%), Gaps = 1/255 (0%) Frame = +1 Query: 322 IGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQIVQELKINQATQSPHIVLCHQSF 501 IG+G+ G V H G+ A+K + +++Q + I+ E+ + + ++ +IV S+ Sbjct: 573 IGQGASGGVFTAYHNGTGSCVAIKQMNLDLQPK-KDLIINEIIVMKDSKHKNIVNFLDSY 631 Query: 502 YHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLYLHHERHVIHRDIKP 681 H +++V+EYM+ GSL D++ + E +A +C++ L GL +LH + VIHRDIK Sbjct: 632 LHGLDLWVVMEYMEGGSLTDVVT-FNIMSEGQIAAVCRETLNGLQHLH-SKGVIHRDIKS 689 Query: 682 SNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISGSSYDYKSDVWSLGL 861 N+L++ G +K+TDFG A + S +R+T VGT +MAPE ++ Y K D+WSLG+ Sbjct: 690 DNILLSLDGNIKLTDFGFCAQINDSHNKRNTMVGTPYWMAPEVVTRKEYGRKVDIWSLGI 749 Query: 862 VILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAPADQ-FSPEFCSFISSCIQKDP 1038 + +E G PY S L I P+ +Q +P F F+ ++ DP Sbjct: 750 MAIEMIEGEPPYLTE------SPLRALYLIATNGTPTIKDEQSLTPVFRDFLHLALKVDP 803 Query: 1039 AERKSASELLNHAFI 1083 +R SA +LL H F+ Sbjct: 804 EKRASAHDLLKHPFM 818
>P35465:PAK1_RAT Serine/threonine-protein kinase PAK 1 - Rattus norvegicus (Rat)| Length = 544 Score = 142 bits (359), Expect = 3e-33 Identities = 88/256 (34%), Positives = 142/256 (55%), Gaps = 1/256 (0%) Frame = +1 Query: 322 IGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQ-IVQELKINQATQSPHIVLCHQS 498 IG+G+ G V G A+K QMN+Q+ +K+ I+ E+ + + ++P+IV S Sbjct: 275 IGQGASGTVYTAMDVATGQEVAIK--QMNLQQQPKKELIINEILVMRENKNPNIVNYLDS 332 Query: 499 FYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLYLHHERHVIHRDIK 678 + +++V+EY+ GSL D++ + + E +A +C++ L+ L +LH + VIHRDIK Sbjct: 333 YLVGDELWVVMEYLAGGSLTDVVTET-CMDEGQIAAVCRECLQALEFLHSNQ-VIHRDIK 390 Query: 679 PSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISGSSYDYKSDVWSLG 858 N+L+ G VK+TDFG A + +R T VGT +MAPE ++ +Y K D+WSLG Sbjct: 391 SDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLG 450 Query: 859 LVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAPADQFSPEFCSFISSCIQKDP 1038 ++ +E G PY E L L+ + P ++ S F F++ C++ D Sbjct: 451 IMAIEMIEGEPPYL---NENPLRALYLI--ATNGTPELQNPEKLSAIFRDFLNRCLEMDV 505 Query: 1039 AERKSASELLNHAFIK 1086 +R SA ELL H F+K Sbjct: 506 EKRGSAKELLQHQFLK 521
>Q13153:PAK1_HUMAN Serine/threonine-protein kinase PAK 1 - Homo sapiens (Human)| Length = 545 Score = 142 bits (359), Expect = 3e-33 Identities = 88/256 (34%), Positives = 142/256 (55%), Gaps = 1/256 (0%) Frame = +1 Query: 322 IGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQ-IVQELKINQATQSPHIVLCHQS 498 IG+G+ G V G A+K QMN+Q+ +K+ I+ E+ + + ++P+IV S Sbjct: 276 IGQGASGTVYTAMDVATGQEVAIK--QMNLQQQPKKELIINEILVMRENKNPNIVNYLDS 333 Query: 499 FYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLYLHHERHVIHRDIK 678 + +++V+EY+ GSL D++ + + E +A +C++ L+ L +LH + VIHRDIK Sbjct: 334 YLVGDELWVVMEYLAGGSLTDVVTET-CMDEGQIAAVCRECLQALEFLHSNQ-VIHRDIK 391 Query: 679 PSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISGSSYDYKSDVWSLG 858 N+L+ G VK+TDFG A + +R T VGT +MAPE ++ +Y K D+WSLG Sbjct: 392 SDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLG 451 Query: 859 LVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAPADQFSPEFCSFISSCIQKDP 1038 ++ +E G PY E L L+ + P ++ S F F++ C++ D Sbjct: 452 IMAIEMIEGEPPYL---NENPLRALYLI--ATNGTPELQNPEKLSAIFRDFLNRCLEMDV 506 Query: 1039 AERKSASELLNHAFIK 1086 +R SA ELL H F+K Sbjct: 507 EKRGSAKELLQHQFLK 522
>Q08E52:PAK1_BOVIN Serine/threonine-protein kinase PAK 1 - Bos taurus (Bovine)| Length = 544 Score = 142 bits (359), Expect = 3e-33 Identities = 88/256 (34%), Positives = 142/256 (55%), Gaps = 1/256 (0%) Frame = +1 Query: 322 IGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQ-IVQELKINQATQSPHIVLCHQS 498 IG+G+ G V G A+K QMN+Q+ +K+ I+ E+ + + ++P+IV S Sbjct: 275 IGQGASGTVYTAMDVATGQEVAIK--QMNLQQQPKKELIINEILVMRENKNPNIVNYLDS 332 Query: 499 FYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLYLHHERHVIHRDIK 678 + +++V+EY+ GSL D++ + + E +A +C++ L+ L +LH + VIHRDIK Sbjct: 333 YLVGDELWVVMEYLAGGSLTDVVTET-CMDEGQIAAVCRECLQALEFLHSNQ-VIHRDIK 390 Query: 679 PSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISGSSYDYKSDVWSLG 858 N+L+ G VK+TDFG A + +R T VGT +MAPE ++ +Y K D+WSLG Sbjct: 391 SDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLG 450 Query: 859 LVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAPADQFSPEFCSFISSCIQKDP 1038 ++ +E G PY E L L+ + P ++ S F F++ C++ D Sbjct: 451 IMAIEMIEGEPPYL---NENPLRALYLI--ATNGTPELQNPEKLSAIFRDFLNRCLEMDV 505 Query: 1039 AERKSASELLNHAFIK 1086 +R SA ELL H F+K Sbjct: 506 EKRGSAKELLQHQFLK 521
>O88643:PAK1_MOUSE Serine/threonine-protein kinase PAK 1 - Mus musculus (Mouse)| Length = 545 Score = 142 bits (358), Expect = 3e-33 Identities = 88/256 (34%), Positives = 141/256 (55%), Gaps = 1/256 (0%) Frame = +1 Query: 322 IGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQ-IVQELKINQATQSPHIVLCHQS 498 IG+G+ G V G A+K QMN+Q+ +K+ I+ E+ + + ++P+IV S Sbjct: 276 IGQGASGTVYTAMDVATGQEVAIK--QMNLQQQPKKELIINEILVMRENKNPNIVNYLDS 333 Query: 499 FYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLYLHHERHVIHRDIK 678 + +++V+EY+ GSL D++ + + E +A +C++ L+ L +LH + VIHRDIK Sbjct: 334 YLVGDELWVVMEYLAGGSLTDVVTET-CMDEGQIAAVCRECLQALEFLHSNQ-VIHRDIK 391 Query: 679 PSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISGSSYDYKSDVWSLG 858 N+L+ G VK+TDFG A + +R T VGT +MAPE ++ +Y K D+WSLG Sbjct: 392 SDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLG 451 Query: 859 LVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAPADQFSPEFCSFISSCIQKDP 1038 ++ +E G PY E L L+ + P ++ S F F+ C++ D Sbjct: 452 IMAIEMIEGEPPYL---NENPLRALYLI--ATNGTPELQNPEKLSAIFRDFLQCCLEMDV 506 Query: 1039 AERKSASELLNHAFIK 1086 +R SA ELL H F+K Sbjct: 507 EKRGSAKELLQHQFLK 522
>Q6C3D7:STE20_YARLI Serine/threonine-protein kinase STE20 - Yarrowia lipolytica (Candida| lipolytica) Length = 1125 Score = 142 bits (357), Expect = 4e-33 Identities = 93/261 (35%), Positives = 146/261 (55%), Gaps = 2/261 (0%) Frame = +1 Query: 322 IGKG-SGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQ-IVQELKINQATQSPHIVLCHQ 495 IG+G SGGV VG+ ++ QMN++ +K+ I+ E+ + + ++ +IV Sbjct: 850 IGQGASGGVFTAYE---VGSNLSVAIKQMNLEHQPKKELIINEILVMKDSKHKNIVNFID 906 Query: 496 SFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLYLHHERHVIHRDI 675 S+ H G +++V+EYM+ GSL D++ + E + +C++ L GL +LH + VIHRDI Sbjct: 907 SYLHGGDLWVVMEYMEGGSLTDVVTY-NMMTESQIGAVCRETLLGLQHLH-SKGVIHRDI 964 Query: 676 KPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISGSSYDYKSDVWSL 855 K N+L++ +GE+K+TDFG A + S +R T VGT +MAPE +S Y K D+WSL Sbjct: 965 KSDNVLLSMRGEIKLTDFGFCAQINESNLKRTTMVGTPYWMAPEVVSRKEYGSKVDIWSL 1024 Query: 856 GLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAPADQFSPEFCSFISSCIQKD 1035 G++ +E G PY E L L+ + P D S F +F++ +Q Sbjct: 1025 GIMSIEMIEGEPPYL---NESPLRALYLI--ATNGTPQLKEPDALSTIFKAFLAWALQVS 1079 Query: 1036 PAERKSASELLNHAFIKKFED 1098 +R SASELL H F+ +D Sbjct: 1080 ADQRASASELLKHEFLLTADD 1100
>O88506:STK39_RAT STE20/SPS1-related proline-alanine-rich protein kinase - Rattus| norvegicus (Rat) Length = 553 Score = 141 bits (356), Expect = 6e-33 Identities = 96/293 (32%), Positives = 152/293 (51%), Gaps = 24/293 (8%) Frame = +1 Query: 298 DDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQIVQELKINQATQSPH 477 D E+ +VIG G+ VVQ K A+K I + ++ ++++E++ P+ Sbjct: 70 DAYELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDELLKEIQAMSQCSHPN 129 Query: 478 IVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQV--------KTILEPYLAVLCKQVLEGL 633 +V + SF ++LV++ + GS+ DIIK + + E +A + K+VLEGL Sbjct: 130 VVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEVLEGL 189 Query: 634 LYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASS-----IGQRDTFVGTYNYM 798 YLH IHRD+K N+L+ G V+I DFGVSA LA+ R TFVGT +M Sbjct: 190 DYLHRNGQ-IHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKTFVGTPCWM 248 Query: 799 APERISG-SSYDYKSDVWSLGLVILECAIGRFPY--TPPEGEGWLSFYELLEAIVDQPPP 969 APE + YD+K+D+WS G+ +E A G PY PP ++L + PP Sbjct: 249 APEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPP--------MKVLMLTLQNDPP 300 Query: 970 SAPA--------DQFSPEFCSFISSCIQKDPAERKSASELLNHAFIKKFEDKD 1104 + ++ F +S C+QKDP++R +A+ELL F +K ++++ Sbjct: 301 TLETGVEDKEMMKKYGKSFRKLLSLCLQKDPSKRPTAAELLKCKFFQKAKNRE 353
>Q9Z1W9:STK39_MOUSE STE20/SPS1-related proline-alanine-rich protein kinase - Mus musculus| (Mouse) Length = 556 Score = 141 bits (356), Expect = 6e-33 Identities = 96/293 (32%), Positives = 152/293 (51%), Gaps = 24/293 (8%) Frame = +1 Query: 298 DDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQIVQELKINQATQSPH 477 D E+ +VIG G+ VVQ K A+K I + ++ ++++E++ P+ Sbjct: 73 DAYELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDELLKEIQAMSQCSHPN 132 Query: 478 IVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQV--------KTILEPYLAVLCKQVLEGL 633 +V + SF ++LV++ + GS+ DIIK + + E +A + K+VLEGL Sbjct: 133 VVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEVLEGL 192 Query: 634 LYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASS-----IGQRDTFVGTYNYM 798 YLH IHRD+K N+L+ G V+I DFGVSA LA+ R TFVGT +M Sbjct: 193 DYLHRNGQ-IHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKTFVGTPCWM 251 Query: 799 APERISG-SSYDYKSDVWSLGLVILECAIGRFPY--TPPEGEGWLSFYELLEAIVDQPPP 969 APE + YD+K+D+WS G+ +E A G PY PP ++L + PP Sbjct: 252 APEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPP--------MKVLMLTLQNDPP 303 Query: 970 SAPA--------DQFSPEFCSFISSCIQKDPAERKSASELLNHAFIKKFEDKD 1104 + ++ F +S C+QKDP++R +A+ELL F +K ++++ Sbjct: 304 TLETGVEDKEMMKKYGKSFRKLLSLCLQKDPSKRPTAAELLKCKFFQKAKNRE 356
>Q9UEW8:STK39_HUMAN STE20/SPS1-related proline-alanine-rich protein kinase - Homo sapiens| (Human) Length = 547 Score = 141 bits (356), Expect = 6e-33 Identities = 96/293 (32%), Positives = 152/293 (51%), Gaps = 24/293 (8%) Frame = +1 Query: 298 DDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQIVQELKINQATQSPH 477 D E+ +VIG G+ VVQ K A+K I + ++ ++++E++ P+ Sbjct: 63 DAYELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDELLKEIQAMSQCSHPN 122 Query: 478 IVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQV--------KTILEPYLAVLCKQVLEGL 633 +V + SF ++LV++ + GS+ DIIK + + E +A + K+VLEGL Sbjct: 123 VVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEVLEGL 182 Query: 634 LYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASS-----IGQRDTFVGTYNYM 798 YLH IHRD+K N+L+ G V+I DFGVSA LA+ R TFVGT +M Sbjct: 183 DYLHRNGQ-IHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKTFVGTPCWM 241 Query: 799 APERISG-SSYDYKSDVWSLGLVILECAIGRFPY--TPPEGEGWLSFYELLEAIVDQPPP 969 APE + YD+K+D+WS G+ +E A G PY PP ++L + PP Sbjct: 242 APEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPP--------MKVLMLTLQNDPP 293 Query: 970 SAPA--------DQFSPEFCSFISSCIQKDPAERKSASELLNHAFIKKFEDKD 1104 + ++ F +S C+QKDP++R +A+ELL F +K ++++ Sbjct: 294 TLETGVEDKEMMKKYGKSFRKLLSLCLQKDPSKRPTAAELLKCKFFQKAKNRE 346
>Q62829:PAK3_RAT Serine/threonine-protein kinase PAK 3 - Rattus norvegicus (Rat)| Length = 544 Score = 141 bits (356), Expect = 6e-33 Identities = 88/256 (34%), Positives = 141/256 (55%), Gaps = 1/256 (0%) Frame = +1 Query: 322 IGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQ-IVQELKINQATQSPHIVLCHQS 498 IG+G+ G V G A+K QMN+Q+ +K+ I+ E+ + + ++P+IV S Sbjct: 274 IGQGASGTVYTALDIATGQEVAIK--QMNLQQQPKKELIINEILVMRENKNPNIVNYLDS 331 Query: 499 FYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLYLHHERHVIHRDIK 678 + +++V+EY+ GSL D++ + + E +A +C++ L+ L +LH + VIHRDIK Sbjct: 332 YLVGDELWVVMEYLAGGSLTDVVTET-CMDEGQIAAVCRECLQALDFLHSNQ-VIHRDIK 389 Query: 679 PSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISGSSYDYKSDVWSLG 858 N+L+ G VK+TDFG A + +R T VGT +MAPE ++ +Y K D+WSLG Sbjct: 390 SDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLG 449 Query: 859 LVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAPADQFSPEFCSFISSCIQKDP 1038 ++ +E G PY E L L+ + P ++ S F F++ C++ D Sbjct: 450 IMAIEMVEGEPPYL---NENPLRALYLI--ATNGTPELQNPERLSAVFRDFLNRCLEMDV 504 Query: 1039 AERKSASELLNHAFIK 1086 R SA ELL H F+K Sbjct: 505 DRRGSAKELLQHPFLK 520
>Q7YQL3:PAK3_PONPY Serine/threonine-protein kinase PAK 3 - Pongo pygmaeus (Orangutan)| Length = 559 Score = 141 bits (356), Expect = 6e-33 Identities = 88/256 (34%), Positives = 141/256 (55%), Gaps = 1/256 (0%) Frame = +1 Query: 322 IGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQ-IVQELKINQATQSPHIVLCHQS 498 IG+G+ G V G A+K QMN+Q+ +K+ I+ E+ + + ++P+IV S Sbjct: 289 IGQGASGTVYTALDIATGQEVAIK--QMNLQQQPKKELIINEILVMRENKNPNIVNYLDS 346 Query: 499 FYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLYLHHERHVIHRDIK 678 + +++V+EY+ GSL D++ + + E +A +C++ L+ L +LH + VIHRDIK Sbjct: 347 YLVGDELWVVMEYLAGGSLTDVVTET-CMDEGQIAAVCRECLQALDFLHSNQ-VIHRDIK 404 Query: 679 PSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISGSSYDYKSDVWSLG 858 N+L+ G VK+TDFG A + +R T VGT +MAPE ++ +Y K D+WSLG Sbjct: 405 SDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLG 464 Query: 859 LVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAPADQFSPEFCSFISSCIQKDP 1038 ++ +E G PY E L L+ + P ++ S F F++ C++ D Sbjct: 465 IMAIEMVEGEPPYL---NENPLRALYLI--ATNGTPELQNPERLSAVFRDFLNRCLEMDV 519 Query: 1039 AERKSASELLNHAFIK 1086 R SA ELL H F+K Sbjct: 520 DRRGSAKELLQHPFLK 535
>Q7YQL4:PAK3_PANTR Serine/threonine-protein kinase PAK 3 - Pan troglodytes (Chimpanzee)| Length = 559 Score = 141 bits (356), Expect = 6e-33 Identities = 88/256 (34%), Positives = 141/256 (55%), Gaps = 1/256 (0%) Frame = +1 Query: 322 IGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQ-IVQELKINQATQSPHIVLCHQS 498 IG+G+ G V G A+K QMN+Q+ +K+ I+ E+ + + ++P+IV S Sbjct: 289 IGQGASGTVYTALDIATGQEVAIK--QMNLQQQPKKELIINEILVMRENKNPNIVNYLDS 346 Query: 499 FYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLYLHHERHVIHRDIK 678 + +++V+EY+ GSL D++ + + E +A +C++ L+ L +LH + VIHRDIK Sbjct: 347 YLVGDELWVVMEYLAGGSLTDVVTET-CMDEGQIAAVCRECLQALDFLHSNQ-VIHRDIK 404 Query: 679 PSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISGSSYDYKSDVWSLG 858 N+L+ G VK+TDFG A + +R T VGT +MAPE ++ +Y K D+WSLG Sbjct: 405 SDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLG 464 Query: 859 LVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAPADQFSPEFCSFISSCIQKDP 1038 ++ +E G PY E L L+ + P ++ S F F++ C++ D Sbjct: 465 IMAIEMVEGEPPYL---NENPLRALYLI--ATNGTPELQNPERLSAVFRDFLNRCLEMDV 519 Query: 1039 AERKSASELLNHAFIK 1086 R SA ELL H F+K Sbjct: 520 DRRGSAKELLQHPFLK 535
>Q61036:PAK3_MOUSE Serine/threonine-protein kinase PAK 3 - Mus musculus (Mouse)| Length = 559 Score = 141 bits (356), Expect = 6e-33 Identities = 88/256 (34%), Positives = 141/256 (55%), Gaps = 1/256 (0%) Frame = +1 Query: 322 IGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQ-IVQELKINQATQSPHIVLCHQS 498 IG+G+ G V G A+K QMN+Q+ +K+ I+ E+ + + ++P+IV S Sbjct: 289 IGQGASGTVYTALDIATGQEVAIK--QMNLQQQPKKELIINEILVMRENKNPNIVNYLDS 346 Query: 499 FYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLYLHHERHVIHRDIK 678 + +++V+EY+ GSL D++ + + E +A +C++ L+ L +LH + VIHRDIK Sbjct: 347 YLVGDELWVVMEYLAGGSLTDVVTET-CMDEGQIAAVCRECLQALDFLHSNQ-VIHRDIK 404 Query: 679 PSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISGSSYDYKSDVWSLG 858 N+L+ G VK+TDFG A + +R T VGT +MAPE ++ +Y K D+WSLG Sbjct: 405 SDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLG 464 Query: 859 LVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAPADQFSPEFCSFISSCIQKDP 1038 ++ +E G PY E L L+ + P ++ S F F++ C++ D Sbjct: 465 IMAIEMVEGEPPYL---NENPLRALYLI--ATNGTPELQNPERLSAVFRDFLNRCLEMDV 519 Query: 1039 AERKSASELLNHAFIK 1086 R SA ELL H F+K Sbjct: 520 DRRGSAKELLQHPFLK 535
>O75914:PAK3_HUMAN Serine/threonine-protein kinase PAK 3 - Homo sapiens (Human)| Length = 559 Score = 141 bits (356), Expect = 6e-33 Identities = 88/256 (34%), Positives = 141/256 (55%), Gaps = 1/256 (0%) Frame = +1 Query: 322 IGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQ-IVQELKINQATQSPHIVLCHQS 498 IG+G+ G V G A+K QMN+Q+ +K+ I+ E+ + + ++P+IV S Sbjct: 289 IGQGASGTVYTALDIATGQEVAIK--QMNLQQQPKKELIINEILVMRENKNPNIVNYLDS 346 Query: 499 FYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLYLHHERHVIHRDIK 678 + +++V+EY+ GSL D++ + + E +A +C++ L+ L +LH + VIHRDIK Sbjct: 347 YLVGDELWVVMEYLAGGSLTDVVTET-CMDEGQIAAVCRECLQALDFLHSNQ-VIHRDIK 404 Query: 679 PSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISGSSYDYKSDVWSLG 858 N+L+ G VK+TDFG A + +R T VGT +MAPE ++ +Y K D+WSLG Sbjct: 405 SDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLG 464 Query: 859 LVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAPADQFSPEFCSFISSCIQKDP 1038 ++ +E G PY E L L+ + P ++ S F F++ C++ D Sbjct: 465 IMAIEMVEGEPPYL---NENPLRALYLI--ATNGTPELQNPERLSAVFRDFLNRCLEMDV 519 Query: 1039 AERKSASELLNHAFIK 1086 R SA ELL H F+K Sbjct: 520 DRRGSAKELLQHPFLK 535
>Q03497:STE20_YEAST Serine/threonine-protein kinase STE20 - Saccharomyces cerevisiae| (Baker's yeast) Length = 939 Score = 140 bits (354), Expect = 1e-32 Identities = 103/359 (28%), Positives = 180/359 (50%), Gaps = 7/359 (1%) Frame = +1 Query: 73 SHSKEEAMRGKKPLKELTLSVPAQETPVDKFLTASGTFKDGELRLNQRGLQLISEEN--- 243 +H+ ++ + K + T++ P + + L+ K E R +R QL ++ N Sbjct: 553 AHTPQQVAQSPKAPAQETVTTPTSKPAQARSLSKELNEKKREER-ERRKKQLYAKLNEIC 611 Query: 244 GDEHQSTKMKVEDVQLSMDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESV 423 D STK + IG+G+ G V +GT ++ QMN+++ Sbjct: 612 SDGDPSTKYA------------NLVKIGQGASGGVYTAYE--IGTNVSVAIKQMNLEKQP 657 Query: 424 RKQ-IVQELKINQATQSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYL 600 +K+ I+ E+ + + ++ P+IV S+ G +++++EYM+ GSL D++ + E + Sbjct: 658 KKELIINEILVMKGSKHPNIVNFIDSYVLKGDLWVIMEYMEGGSLTDVVTHC-ILTEGQI 716 Query: 601 AVLCKQVLEGLLYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFV 780 +C++ L GL +LH + V+HRDIK N+L++ +G++K+TDFG A + +R T V Sbjct: 717 GAVCRETLSGLEFLH-SKGVLHRDIKSDNILLSMEGDIKLTDFGFCAQINELNLKRTTMV 775 Query: 781 GTYNYMAPERISGSSYDYKSDVWSLGLVILECAIGRFPY---TPPEGEGWLSFYELLEAI 951 GT +MAPE +S Y K D+WSLG++I+E G PY TP L Sbjct: 776 GTPYWMAPEVVSRKEYGPKVDIWSLGIMIIEMIEGEPPYLNETP--------LRALYLIA 827 Query: 952 VDQPPPSAPADQFSPEFCSFISSCIQKDPAERKSASELLNHAFIKKFEDKDLDLRILVE 1128 + P + S F+ C+ +P +R SA+ELL+ +I + + + L LV+ Sbjct: 828 TNGTPKLKEPENLSSSLKKFLDWCLCVEPEDRASATELLHDEYITEIAEANSSLAPLVK 886
>O96013:PAK4_HUMAN Serine/threonine-protein kinase PAK 4 - Homo sapiens (Human)| Length = 591 Score = 140 bits (354), Expect = 1e-32 Identities = 86/259 (33%), Positives = 145/259 (55%), Gaps = 3/259 (1%) Frame = +1 Query: 322 IGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQIVQELKINQATQSPHIVLCHQSF 501 IG+GS G+V + + G A+K + + Q+ R+ + E+ I + Q ++V + S+ Sbjct: 327 IGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQR-RELLFNEVVIMRDYQHENVVEMYNSY 385 Query: 502 YHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLYLHHERHVIHRDIKP 681 +++V+E+++ G+L DI+ + + E +A +C VL+ L LH + VIHRDIK Sbjct: 386 LVGDELWVVMEFLEGGALTDIVTHTR-MNEEQIAAVCLAVLQALSVLHAQG-VIHRDIKS 443 Query: 682 SNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISGSSYDYKSDVWSLGL 861 ++L+ H G VK++DFG A ++ + +R + VGT +MAPE IS Y + D+WSLG+ Sbjct: 444 DSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGI 503 Query: 862 VILECAIGRFPY--TPPEGEGWLSFYELLEAIVDQPPPSAP-ADQFSPEFCSFISSCIQK 1032 +++E G PY PP + ++ I D PP + SP F+ + + Sbjct: 504 MVIEMVDGEPPYFNEPP--------LKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVR 555 Query: 1033 DPAERKSASELLNHAFIKK 1089 DPA+R +A+ELL H F+ K Sbjct: 556 DPAQRATAAELLKHPFLAK 574
>Q5BBL3:STE20_EMENI Serine/threonine-protein kinase ste20 - Emericella nidulans| (Aspergillus nidulans) Length = 848 Score = 140 bits (353), Expect = 1e-32 Identities = 83/254 (32%), Positives = 136/254 (53%) Frame = +1 Query: 322 IGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQIVQELKINQATQSPHIVLCHQSF 501 IG+G+ G V + A+K + +++Q + I+ E+ + + ++ +IV S+ Sbjct: 573 IGQGASGGVFTAYEQHTNNCVAIKQMNLDLQPK-KDLIINEILVMKDSKHKNIVNFLDSY 631 Query: 502 YHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLYLHHERHVIHRDIKP 681 H +++V+EYM+ GSL D++ + EP +A +C++ L GL +LH + VIHRDIK Sbjct: 632 LHGLDLWVVMEYMEGGSLTDVVT-FNIMSEPQIAAVCRETLNGLQHLH-SKGVIHRDIKS 689 Query: 682 SNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISGSSYDYKSDVWSLGL 861 N+L++ G +K+TDFG A + S +R+T VGT +MAPE ++ Y K D+WSLG+ Sbjct: 690 DNILLSLDGNIKLTDFGFCAQINDSQNKRNTMVGTPYWMAPEVVTRKEYGRKVDIWSLGI 749 Query: 862 VILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAPADQFSPEFCSFISSCIQKDPA 1041 + +E G PY L + P SP F F+ ++ DP Sbjct: 750 MAIEMIEGEPPYLTES-----PLRALYLIATNGTPKIKDEHNLSPVFKDFLHFALRVDPE 804 Query: 1042 ERKSASELLNHAFI 1083 +R SA +LL H F+ Sbjct: 805 KRASAHDLLKHPFM 818
>Q7Z8E9:STE20_MAGGR Serine/threonine-protein kinase MST20 - Magnaporthe grisea (Rice| blast fungus) (Pyricularia grisea) Length = 914 Score = 139 bits (351), Expect = 2e-32 Identities = 86/257 (33%), Positives = 139/257 (54%), Gaps = 3/257 (1%) Frame = +1 Query: 322 IGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQ-IVQELKINQATQSPHIVLCHQS 498 IG+G+ G V + A+K QMN+++ +K I+ E+ + + + P+IV S Sbjct: 640 IGQGASGGVYTGHERGSNRLVAIK--QMNLEQQPKKDLIINEILVMKDSSHPNIVNFIDS 697 Query: 499 FYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLYLHHERHVIHRDIK 678 + G +++V+E+M+ GSL D++ + E +A +C++ L GL +LH + VIHRDIK Sbjct: 698 YLCGGELWVVMEFMEGGSLTDVVT-FNIMTEGQIASVCRETLLGLQHLH-SKGVIHRDIK 755 Query: 679 PSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISGSSYDYKSDVWSLG 858 N+L++ +G +K+TDFG A + + +R T VGT +MAPE ++ Y K D+WSLG Sbjct: 756 SDNILLSMEGNIKLTDFGFCATINEAQNKRTTMVGTPYWMAPEVVTRKEYGRKVDIWSLG 815 Query: 859 LVILECAIGRFPY--TPPEGEGWLSFYELLEAIVDQPPPSAPADQFSPEFCSFISSCIQK 1032 ++ +E G PY P WL + P SP F F+ ++ Sbjct: 816 IMAIEMIEGEPPYLTESPLRALWL-------IATNGTPQIKDEGNMSPVFRDFLYFALKV 868 Query: 1033 DPAERKSASELLNHAFI 1083 DP +R SA +LL H F+ Sbjct: 869 DPDKRASAHDLLRHEFM 885
>Q6CVA2:STE20_KLULA Serine/threonine-protein kinase STE20 - Kluyveromyces lactis (Yeast)| (Candida sphaerica) Length = 989 Score = 139 bits (351), Expect = 2e-32 Identities = 93/305 (30%), Positives = 161/305 (52%), Gaps = 7/305 (2%) Frame = +1 Query: 235 EENGDEHQSTKMKVEDVQLSMDDLEMIQ---VIGKGSGGVVQLVRHKWVGTFYALKGIQM 405 EE ++Q + K+ ++ + D ++ + IG+G+ G V A+K QM Sbjct: 672 EERKRKNQQIQSKLTEICTTGDPSKLYKNLIKIGQGASGGVYTAYELGTNASVAIK--QM 729 Query: 406 NIQESVRKQ-IVQELKINQATQSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKT 582 N+++ +K+ IV E+ + + ++ +IV S+ G +++V+EYM+ GSL D++ Sbjct: 730 NLEKQPKKELIVNEILVMKGSKHNNIVNFIDSYLFRGDLWVVMEYMEGGSLTDVVTHC-I 788 Query: 583 ILEPYLAVLCKQVLEGLLYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIG 762 + E + + ++ L+GL +LH + VIHRDIK N+L++ G++K+TDFG A + Sbjct: 789 LTEGQIGAVSRETLKGLQFLH-SKGVIHRDIKSDNILLSMNGDIKLTDFGFCAQINEVNL 847 Query: 763 QRDTFVGTYNYMAPERISGSSYDYKSDVWSLGLVILECAIGRFPY---TPPEGEGWLSFY 933 +R T VGT +MAPE +S Y K D+WSLG++I+E G PY TP Sbjct: 848 KRTTMVGTPYWMAPEVVSRKEYGPKVDIWSLGIMIIEMIEGEPPYLNETP--------LR 899 Query: 934 ELLEAIVDQPPPSAPADQFSPEFCSFISSCIQKDPAERKSASELLNHAFIKKFEDKDLDL 1113 L + P S + F++ C+ DP +R +A++LL FI + +++ L Sbjct: 900 ALYLIATNGTPKLKDPGNLSHKMAMFLNWCLMVDPEDRGTAADLLEDPFITEIAEENTSL 959 Query: 1114 RILVE 1128 LV+ Sbjct: 960 APLVK 964
>P38692:KIC1_YEAST Serine/threonine-protein kinase KIC1 - Saccharomyces cerevisiae| (Baker's yeast) Length = 1080 Score = 139 bits (351), Expect = 2e-32 Identities = 88/280 (31%), Positives = 152/280 (54%), Gaps = 3/280 (1%) Frame = +1 Query: 256 QSTKMKVEDVQLSMDDL-EMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQ 432 Q++K + + ++ + L + +VIG+G GVV + G YA+K + ++ + Sbjct: 6 QNSKQGLAEGEMDVSSLFKRTEVIGRGKFGVVYKGYNVKTGRVYAIKVLNLDSDSDEVED 65 Query: 433 IVQELK-INQATQSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVL 609 + +E++ + Q +I + S+ + +++++E+ GSL +++ K I E Y+ V+ Sbjct: 66 VQREIQFLASLKQISNITRYYGSYLKDTSLWIIMEHCAGGSLRSLLRPGK-IDEKYIGVI 124 Query: 610 CKQVLEGLLYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTY 789 +++L L +H + +VIHRDIK +N+L+ ++G VK+ DFGV+A + + +R T GT Sbjct: 125 MRELLVALKCIHKD-NVIHRDIKAANVLITNEGNVKLCDFGVAAQVNQTSLRRQTMAGTP 183 Query: 790 NYMAPERI-SGSSYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPP 966 +MAPE I G YD K D+WSLG+ E A G PY E ++ I+ P Sbjct: 184 YWMAPEVIMEGVYYDTKVDIWSLGITTYEIATGNPPYCDVEA------LRAMQLIIKSKP 237 Query: 967 PSAPADQFSPEFCSFISSCIQKDPAERKSASELLNHAFIK 1086 P +S FI+ C+ +DP ER SA +LL FI+ Sbjct: 238 PRLEDRSYSTSLKEFIALCLDEDPKERLSADDLLKSKFIR 277
>Q9N0X0:AURKB_PIG Serine/threonine-protein kinase 12 - Sus scrofa (Pig)| Length = 344 Score = 139 bits (350), Expect = 3e-32 Identities = 93/292 (31%), Positives = 157/292 (53%), Gaps = 2/292 (0%) Frame = +1 Query: 217 GLQLISEENGDEHQSTKMKVEDVQLSMDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKG 396 G +++ +G + ST+ ++DD E+ + +GKG G V L R K ALK Sbjct: 54 GQKVVENSSGTPNFSTR------SFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKV 107 Query: 397 IQMNI--QESVRKQIVQELKINQATQSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIK 570 + + +E V Q+ +E++I Q P+I+ + FY IYL+LEY RG L ++ Sbjct: 108 LFKSQIEKEGVEHQLRREIEIQAHLQHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQ 167 Query: 571 QVKTILEPYLAVLCKQVLEGLLYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLA 750 + +T E A + +++ + L+Y H ++ VIHRDIKP NLL+ +GE+KI DFG S V A Sbjct: 168 KCRTFDEQRTATIMEELADALIYCHGKK-VIHRDIKPENLLLGLQGELKIADFGWS-VHA 225 Query: 751 SSIGQRDTFVGTYNYMAPERISGSSYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSF 930 S+ +R T GT +Y+ PE I G +++ K D+W +G++ E +G P+ E Sbjct: 226 PSL-RRKTMCGTLDYLPPEMIEGRTHNEKVDLWCIGVLCYELLVGNPPF---ESASHNET 281 Query: 931 YELLEAIVDQPPPSAPADQFSPEFCSFISSCIQKDPAERKSASELLNHAFIK 1086 Y + + + PPS PA IS ++ +P++R +++ H +++ Sbjct: 282 YRRIGKVDLKFPPSVPAGA-----QDLISKLLKHNPSDRLPLAQVSAHPWVR 328
>Q4P5N0:STE20_USTMA Serine/threonine-protein kinase SMU1 - Ustilago maydis (Smut fungus)| Length = 746 Score = 139 bits (349), Expect = 4e-32 Identities = 91/263 (34%), Positives = 147/263 (55%), Gaps = 2/263 (0%) Frame = +1 Query: 313 IQVIGKG-SGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQ-IVQELKINQATQSPHIVL 486 +Q IG+G SGGV + VGT ++ QMN+++ +K I+ E+ + + ++ +IV Sbjct: 475 LQKIGQGASGGVFTAYQ---VGTNVSVAIKQMNLEQQPKKDLIINEILVMKESRHRNIVN 531 Query: 487 CHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLYLHHERHVIH 666 SF G +++V+EYM+ GSL D++ + E +A + ++VLEGL +LH + VIH Sbjct: 532 FIDSFLFKGDLWVVMEYMEGGSLTDVVT-CNIMTEGQIAAVSREVLEGLRHLH-QHGVIH 589 Query: 667 RDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISGSSYDYKSDV 846 RDIK N+L++ +G++K+TDFG A + S +R T VGT +MAPE ++ Y K D+ Sbjct: 590 RDIKSDNVLLSLQGDIKLTDFGFCAQIGESQAKRTTMVGTPYWMAPEVVTRKEYGPKVDI 649 Query: 847 WSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAPADQFSPEFCSFISSCI 1026 WSLG++ +E G PY E L L+ + P + S F F+++ + Sbjct: 650 WSLGIMCIEMVEGEPPYL---NENPLRALYLI--ATNGTPKINNPENLSNTFKDFLTTSL 704 Query: 1027 QKDPAERKSASELLNHAFIKKFE 1095 D R A +L H F+K+ E Sbjct: 705 DVDAERRPDALGMLAHPFLKRSE 727
>Q2VWQ3:STE20_PENMA Serine/threonine-protein kinase pakA - Penicillium marneffei| Length = 642 Score = 139 bits (349), Expect = 4e-32 Identities = 86/255 (33%), Positives = 138/255 (54%), Gaps = 1/255 (0%) Frame = +1 Query: 322 IGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQIVQELKINQATQSPHIVLCHQSF 501 IG+G+ G V A+K + +++Q + I+ E+ + + ++ +IV S+ Sbjct: 367 IGQGASGGVFTAYETNTNKCVAIKQMNLDLQPK-KDLIINEILVMKDSKHKNIVNFLDSY 425 Query: 502 YHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLYLHHERHVIHRDIKP 681 H +++V+EYM+ GSL D++ + E +A +C++ L GL +LH + VIHRDIK Sbjct: 426 LHGLDLWVVMEYMEGGSLTDVVT-FNIMSEGQIAAVCRETLSGLQHLH-SKGVIHRDIKS 483 Query: 682 SNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISGSSYDYKSDVWSLGL 861 N+L++ GE+K+TDFG A + S +R+T VGT +MAPE ++ Y K D+WSLG+ Sbjct: 484 DNILLSMDGEIKLTDFGFCAQINDSQNKRNTMVGTPYWMAPEVVTRKEYGRKVDIWSLGI 543 Query: 862 VILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAPADQ-FSPEFCSFISSCIQKDP 1038 + +E G PY S L I P +Q SP F F+ ++ DP Sbjct: 544 MAIEMIEGEPPYLTE------SPLRALYLIATNGTPKIKDEQNLSPVFRDFLHLALRVDP 597 Query: 1039 AERKSASELLNHAFI 1083 +R SA +LL H F+ Sbjct: 598 EKRASAHDLLKHPFM 612
>Q10056:SHK2_SCHPO Serine/threonine-protein kinase shk2 - Schizosaccharomyces pombe| (Fission yeast) Length = 589 Score = 139 bits (349), Expect = 4e-32 Identities = 92/280 (32%), Positives = 155/280 (55%), Gaps = 8/280 (2%) Frame = +1 Query: 274 VEDVQLSMDDLEMIQV---IGKGSGGVVQLVR---HKWVGTFYALKGIQMNIQESVRKQI 435 ++D S D +E V +G+G+ G V L + K +G F ++ +++Q RK++ Sbjct: 296 LKDSVTSHDPVEYFNVKHKLGQGASGSVYLAKVVGGKQLGIFDSVAIKSIDLQCQTRKEL 355 Query: 436 V-QELKINQATQSPHIVLCHQSFY-HNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVL 609 + E+ + + + P+IV SF +++V+EYM+ GSL DII++ K + E +A + Sbjct: 356 ILNEITVMRESIHPNIVTYLDSFLVRERHLWVVMEYMNAGSLTDIIEKSK-LTEAQIARI 414 Query: 610 CKQVLEGLLYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTY 789 C + +G+ +LH R++IHRDIK N+L+++ G +KITDFG A L++ +R T VGT Sbjct: 415 CLETCKGIQHLH-ARNIIHRDIKSDNVLLDNSGNIKITDFGFCARLSNRTNKRVTMVGTP 473 Query: 790 NYMAPERISGSSYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPP 969 +MAPE + + Y K D+WSLG++I+E PY + L + P Sbjct: 474 YWMAPEVVKQNEYGTKVDIWSLGIMIIEMIENEPPYLRED-----PIRALYLIAKNGTPT 528 Query: 970 SAPADQFSPEFCSFISSCIQKDPAERKSASELLNHAFIKK 1089 + S SF++SC+ D R +A+ELL H+F+ + Sbjct: 529 LKKPNLVSKNLKSFLNSCLTIDTIFRATAAELLTHSFLNQ 568
>Q8BTW9:PAK4_MOUSE Serine/threonine-protein kinase PAK 4 - Mus musculus (Mouse)| Length = 593 Score = 139 bits (349), Expect = 4e-32 Identities = 85/259 (32%), Positives = 145/259 (55%), Gaps = 3/259 (1%) Frame = +1 Query: 322 IGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQIVQELKINQATQSPHIVLCHQSF 501 IG+GS G+V + + G A+K + + Q+ R+ + E+ I + + ++V + S+ Sbjct: 329 IGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQR-RELLFNEVVIMRDYRHENVVEMYNSY 387 Query: 502 YHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLYLHHERHVIHRDIKP 681 +++V+E+++ G+L DI+ + + E +A +C VL+ L LH + VIHRDIK Sbjct: 388 LVGDELWVVMEFLEGGALTDIVTHTR-MNEEQIAAVCLAVLQALAVLHAQG-VIHRDIKS 445 Query: 682 SNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISGSSYDYKSDVWSLGL 861 ++L+ H G VK++DFG A ++ + +R + VGT +MAPE IS Y + D+WSLG+ Sbjct: 446 DSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGV 505 Query: 862 VILECAIGRFPY--TPPEGEGWLSFYELLEAIVDQPPPSAP-ADQFSPEFCSFISSCIQK 1032 +++E G PY PP + ++ I D PP + SP F+ + + Sbjct: 506 MVIEMVDGEPPYFNEPP--------LKAMKMIRDNLPPRLKNLHKASPSLKGFLDRLLVR 557 Query: 1033 DPAERKSASELLNHAFIKK 1089 DPA+R +A+ELL H F+ K Sbjct: 558 DPAQRATAAELLKHPFLTK 576
>Q92918:M4K1_HUMAN Mitogen-activated protein kinase kinase kinase kinase 1 - Homo| sapiens (Human) Length = 833 Score = 138 bits (348), Expect = 5e-32 Identities = 95/312 (30%), Positives = 167/312 (53%), Gaps = 3/312 (0%) Frame = +1 Query: 298 DDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQIVQELKINQATQSPH 477 D +++Q +G G+ G V R K G ALK ++M + V + +E+ I + + + Sbjct: 15 DHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDV-STLQKEILILKTCRHAN 73 Query: 478 IVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLYLHHERH 657 IV H S+ +++ +E+ GSL DI + ++ E ++ +C++VL+GL YLH ++ Sbjct: 74 IVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYLHSQKK 133 Query: 658 VIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERIS---GSSY 828 IHRDIK +N+L+N GEV++ DFG+SA + +++ +R +F+GT +MAPE + Y Sbjct: 134 -IHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPEVAAVALKGGY 192 Query: 829 DYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAPADQFSPEFCS 1008 + D+WSLG+ +E A + P L L+ QPP ++S F + Sbjct: 193 NELCDIWSLGITAIELAELQPPLFDVHP---LRVLFLMTKSGYQPPRLKEKGKWSAAFHN 249 Query: 1009 FISSCIQKDPAERKSASELLNHAFIKKFEDKDLDLRILVESLEQPMNVPE*GLPLGEARL 1188 FI + K P +R SA+++L+H + + L+ ++++ L++ N P G +G+ Sbjct: 250 FIKVTLTKSPKKRPSATKMLSHQLVSQ---PGLNRGLILDLLDKLKN-PGKGPSIGDIED 305 Query: 1189 CGDSLPGPPSRR 1224 LP RR Sbjct: 306 EEPELPPAIPRR 317
>Q4WHP3:STE20_ASPFU Serine/threonine-protein kinase ste20 - Aspergillus fumigatus| (Sartorya fumigata) Length = 815 Score = 138 bits (347), Expect = 6e-32 Identities = 88/256 (34%), Positives = 138/256 (53%), Gaps = 2/256 (0%) Frame = +1 Query: 322 IGKG-SGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQ-IVQELKINQATQSPHIVLCHQ 495 IG+G SGGV +H GT + QMN+ +K+ I+ E+ + + ++ +IV Sbjct: 540 IGQGASGGVYTAYQH---GTNNCVAIKQMNLDLQPKKELIINEILVMKDSKHKNIVNFLD 596 Query: 496 SFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLYLHHERHVIHRDI 675 S+ H +++V+EYM+ GSL D++ + E +A +C++ L GL +LH + VIHRDI Sbjct: 597 SYLHGLDLWVVMEYMEGGSLTDVVT-FNIMTEGQIAAVCRETLNGLQHLH-SKGVIHRDI 654 Query: 676 KPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISGSSYDYKSDVWSL 855 K N+L++ G +K+TDFG A + S +R+T VGT +MAPE ++ Y K D+WSL Sbjct: 655 KSDNILLSLDGNIKLTDFGFCAQINDSQNKRNTMVGTPYWMAPEVVTRKEYGRKVDIWSL 714 Query: 856 GLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAPADQFSPEFCSFISSCIQKD 1035 G++ +E G PY L + P SP F F+ ++ D Sbjct: 715 GIMAIEMIEGEPPYLTES-----PLRALYLIATNGTPTIKDEHNLSPVFRDFLHLALKVD 769 Query: 1036 PAERKSASELLNHAFI 1083 P +R SA +LL H F+ Sbjct: 770 PEKRASAHDLLMHPFM 785
>Q7Z2Y5:NRK_HUMAN Nik-related protein kinase - Homo sapiens (Human)| Length = 1582 Score = 138 bits (347), Expect = 6e-32 Identities = 93/311 (29%), Positives = 165/311 (53%), Gaps = 38/311 (12%) Frame = +1 Query: 316 QVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQIVQELKINQATQS-------- 471 + IG G+ G + L H+ G F A+K MN +++ +I + +++N+ +S Sbjct: 29 KTIGLGTYGRIYLGLHEKTGAFTAVK--VMNARKTPLPEIGRRVRVNKYQKSVGWRYSDE 86 Query: 472 -----PHIVLCHQSFYHNGVI------------------YLVLEYMDRGSLADIIKQV-- 576 + L + +H ++ ++V+E GS+ D+++ Sbjct: 87 EEDLRTELNLLRKYSFHKNIVSFYGAFFKLSPPGQRHQLWMVMELCAAGSVTDVVRMTSN 146 Query: 577 KTILEPYLAVLCKQVLEGLLYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASS 756 +++ E ++A +C+++L+GL +LH R VIHRDIK N+L+ H EVK+ DFGVSA ++ + Sbjct: 147 QSLKEDWIAYICREILQGLAHLHAHR-VIHRDIKGQNVLLTHNAEVKLVDFGVSAQVSRT 205 Query: 757 IGQRDTFVGTYNYMAPERIS-----GSSYDYKSDVWSLGLVILECAIGRFPYTPPEGEGW 921 G+R++F+GT +MAPE I SYDY+SDVWS+G+ +E A G P Sbjct: 206 NGRRNSFIGTPYWMAPEVIDCDEDPRRSYDYRSDVWSVGITAIEMAEGAPPLCN------ 259 Query: 922 LSFYELLEAIVDQPPPSAPADQFSPEFCSFISSCIQKDPAERKSASELLNHAFIKKFEDK 1101 L E L I+ + P+ + +S +F +F+ C K+ R +++ +L H F++ +++ Sbjct: 260 LQPLEALFVILRESAPTVKSSGWSRKFHNFMEKCTIKNFLFRPTSANMLQHPFVRDIKNE 319 Query: 1102 DLDLRILVESL 1134 R +VESL Sbjct: 320 ----RHVVESL 326
>Q6BNF3:STE20_DEBHA Serine/threonine-protein kinase STE20 - Debaryomyces hansenii (Yeast)| (Torulaspora hansenii) Length = 1079 Score = 137 bits (345), Expect = 1e-31 Identities = 97/298 (32%), Positives = 159/298 (53%), Gaps = 10/298 (3%) Frame = +1 Query: 235 EENGDEHQSTKMKVEDVQLSMDDLEM---IQVIGKGSGGVVQL---VRHKWVGTFYALKG 396 E+ ++Q K++ + D E+ + IG+G+ G V + V H+ A+K Sbjct: 775 EDKKRKNQQIISKLQQICSEGDPNELYKDLMKIGQGASGGVYIAHDVNHR--SQTVAIK- 831 Query: 397 IQMNIQESVRKQ-IVQELKINQATQSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQ 573 QMN+++ +K+ I+ E+ + + ++ +IV S+ G +++V+EYM+ GSL +I+ Sbjct: 832 -QMNLEQQPKKELIINEILVMKGSKHENIVNFIDSYLLRGDLWVVMEYMEGGSLTEIVTH 890 Query: 574 VKTILEPYLAVLCKQVLEGLLYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLAS 753 + E + +C++ L+GL +LH + VIHRDIK N+L+N G +K+TDFG A + Sbjct: 891 -SVMTEGQIGAVCRETLKGLRFLH-SKGVIHRDIKSDNILLNIDGNIKMTDFGFCAQINE 948 Query: 754 SIGQRDTFVGTYNYMAPERISGSSYDYKSDVWSLGLVILECAIGRFPY---TPPEGEGWL 924 +R T VGT +MAPE +S Y K DVWSLG++I+E G PY TP Sbjct: 949 INLKRTTMVGTPYWMAPEVVSRKEYGPKVDVWSLGIMIIEMIEGEPPYLNETP------- 1001 Query: 925 SFYELLEAIVDQPPPSAPADQFSPEFCSFISSCIQKDPAERKSASELLNHAFIKKFED 1098 L + P + S + F+S C+Q D +R +A +LLN FI + +D Sbjct: 1002 -LRALYLIATNGTPKLKEPEALSYDIRKFLSWCLQVDFNKRGNADQLLNDKFILEADD 1058
>P51957:NEK4_HUMAN Serine/threonine-protein kinase Nek4 - Homo sapiens (Human)| Length = 841 Score = 137 bits (345), Expect = 1e-31 Identities = 84/263 (31%), Positives = 139/263 (52%), Gaps = 4/263 (1%) Frame = +1 Query: 313 IQVIGKGSGGVVQLVRHKWVGTFYALKGIQM-NIQESVRKQIVQELKINQATQSPHIVLC 489 ++V+GKGS G V LV+H+ G Y +K + + N R+ QE ++ + P+IV Sbjct: 9 LRVVGKGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQLKHPNIVTY 68 Query: 490 HQSFYH-NGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVL--CKQVLEGLLYLHHERHV 660 +S+ +G++Y+V+ + + G L +K+ K L P V+ Q+ L YLH E+H+ Sbjct: 69 KESWEGGDGLLYIVMGFCEGGDLYRKLKEQKGQLLPENQVVEWFVQIAMALQYLH-EKHI 127 Query: 661 IHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISGSSYDYKS 840 +HRD+K N+ + +K+ D G++ VL + T +GT YM+PE S Y+YKS Sbjct: 128 LHRDLKTQNVFLTRTNIIKVGDLGIARVLENHCDMASTLIGTPYYMSPELFSNKPYNYKS 187 Query: 841 DVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAPADQFSPEFCSFISS 1020 DVW+LG + E A + + + L+ I++ P+ P D +SPE I + Sbjct: 188 DVWALGCCVYEMATLKHAFNAKD------MNSLVYRIIEGKLPAMPRD-YSPELAELIRT 240 Query: 1021 CIQKDPAERKSASELLNHAFIKK 1089 + K P ER S +L +IK+ Sbjct: 241 MLSKRPEERPSVRSILRQPYIKR 263
>Q23977:HEP_DROME Dual specificity mitogen-activated protein kinase kinase hemipterous| - Drosophila melanogaster (Fruit fly) Length = 1178 Score = 137 bits (344), Expect = 1e-31 Identities = 92/312 (29%), Positives = 157/312 (50%), Gaps = 6/312 (1%) Frame = +1 Query: 220 LQLISEENGDEHQSTKMKVEDVQLSMDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGI 399 L++I E+ G + + + D+ +DL+ + +G G+ G V + H T A+K + Sbjct: 173 LKIIMEQTGKLNINGRQYPTDI----NDLKHLGDLGNGTSGNVVKMMHLSSNTIIAVKQM 228 Query: 400 QMNIQESVRKQIVQELKIN-QATQSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQV 576 + K+I+ +L + ++ +IV C F + +++ +E M + Sbjct: 229 RRTGNAEENKRILMDLDVVLKSHDCKYIVKCLGCFVRDPDVWICMELMSMCFDKLLKLSK 288 Query: 577 KTILEPYLAVLCKQVLEGLLYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASS 756 K + E L + + L YL + VIHRD+KPSN+L++ +G +K+ DFG+S L S Sbjct: 289 KPVPEQILGKVTVATVNALSYLKDKHGVIHRDVKPSNILIDERGNIKLCDFGISGRLVDS 348 Query: 757 IGQRDTFVGTYNYMAPERISGS--SYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSF 930 + G YMAPERI YD ++DVWSLG+ ++E A R PY EG + Sbjct: 349 KANTRS-AGCAAYMAPERIDPKKPKYDIRADVWSLGITLVELATARSPY-----EGCNTD 402 Query: 931 YELLEAIVDQPPPSAPADQ---FSPEFCSFISSCIQKDPAERKSASELLNHAFIKKFEDK 1101 +E+L ++D PP P + FS +F F+ C+ K+ +R ELL FI+ +E Sbjct: 403 FEVLTKVLDSEPPCLPYGEGYNFSQQFRDFVIKCLTKNHQDRPKYPELLAQPFIRIYESA 462 Query: 1102 DLDLRILVESLE 1137 +D+ +S++ Sbjct: 463 KVDVPNWFQSIK 474
>Q8NEV4:MYO3A_HUMAN Myosin IIIA - Homo sapiens (Human)| Length = 1616 Score = 136 bits (343), Expect = 2e-31 Identities = 103/289 (35%), Positives = 159/289 (55%), Gaps = 16/289 (5%) Frame = +1 Query: 298 DDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQIVQELKINQA-TQSP 474 D E+ + IGKG+ G V V +K G A+K ++ + ++I E I +A + P Sbjct: 19 DTWEITETIGKGTYGKVFKVLNKKNGQKAAVK--ILDPIHDIDEEIEAEYNILKALSDHP 76 Query: 475 HIVLCHQSFYH----NG-VIYLVLEYMDRGSLADIIK----QVKTILEPYLAVLCKQVLE 627 ++V + ++ NG ++LVLE GS+ D++K + + + EP +A + + L Sbjct: 77 NVVRFYGIYFKKDKVNGDKLWLVLELCSGGSVTDLVKGFLKRGERMSEPLIAYILHEALM 136 Query: 628 GLLYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPE 807 GL +LH+ + IHRD+K +N+L+ +G VK+ DFGVSA L S+ +R+T VGT +MAPE Sbjct: 137 GLQHLHNNK-TIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRHRRNTSVGTPFWMAPE 195 Query: 808 RIS-----GSSYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPS 972 I+ ++YD + D WSLG+ +E G PP + L L I PPP Sbjct: 196 VIACEQQLDTTYDARCDTWSLGITAIELGDG----DPPLAD--LHPMRALFKIPRNPPPK 249 Query: 973 -APADQFSPEFCSFISSCIQKDPAERKSASELLNHAFIKKFEDKDLDLR 1116 + +S EF FIS C+ KD +R + SELL H FI + E KD+ L+ Sbjct: 250 LRQPELWSAEFNDFISKCLTKDYEKRPTVSELLQHKFITQIEGKDVMLQ 298
>Q7YRC6:AURKB_BOVIN Serine/threonine-protein kinase 12 - Bos taurus (Bovine)| Length = 344 Score = 136 bits (342), Expect = 2e-31 Identities = 91/281 (32%), Positives = 149/281 (53%), Gaps = 2/281 (0%) Frame = +1 Query: 250 EHQSTKMKVEDVQLSMDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNI--QESV 423 E+ S + ++DD E+ + +GKG G V L R K ALK + + +E V Sbjct: 59 ENSSGTPNIPKRSFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGV 118 Query: 424 RKQIVQELKINQATQSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLA 603 Q+ +E++I Q P+I+ + FY IYL+LEY RG L +++ +T E A Sbjct: 119 EHQLRREIEIQAHLQHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSRTFDEQRTA 178 Query: 604 VLCKQVLEGLLYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVG 783 + +++ + L Y H ++ VIHRDIKP NLL+ +GE+KI DFG S V A S+ +R T G Sbjct: 179 TIMEELADALTYCHAKK-VIHRDIKPENLLLGLRGELKIADFGWS-VHAPSL-RRKTMCG 235 Query: 784 TYNYMAPERISGSSYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQP 963 T +Y+ PE I G +++ K D+W +G++ E +G P+ E Y + + + Sbjct: 236 TLDYLPPEMIEGRTHNEKVDLWCIGVLCYELLVGNPPF---ESASHNETYRRIVKVDLKF 292 Query: 964 PPSAPADQFSPEFCSFISSCIQKDPAERKSASELLNHAFIK 1086 PPS P FI ++ +P+ER +++ H +++ Sbjct: 293 PPSVPLGA-----QDFIYKLLKHNPSERLPLAQVSAHPWVR 328
>Q1EG27:MYO3B_MOUSE Myosin-IIIB - Mus musculus (Mouse)| Length = 1305 Score = 135 bits (341), Expect = 3e-31 Identities = 106/297 (35%), Positives = 162/297 (54%), Gaps = 16/297 (5%) Frame = +1 Query: 274 VEDVQLSMDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQIVQELKI 453 +E + M+ E+I+ IGKG+ G V V +K G+ A+K ++ + ++I E I Sbjct: 5 LESLPDPMETWEIIETIGKGTYGKVYKVANKRDGSLAAVK--VLDPVSDMDEEIEAEYNI 62 Query: 454 NQATQS-PHIVLCHQSFYH-----NGVIYLVLEYMDRGSLADIIKQV----KTILEPYLA 603 Q S P++V + FY G ++LVLE + GS+ +++K + K + E ++ Sbjct: 63 LQFLPSHPNVVKFYGMFYKADRCVGGQLWLVLELCNGGSVTELVKGLLRCGKRLDEAVIS 122 Query: 604 VLCKQVLEGLLYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVG 783 + L GL +LH R +IHRD+K +N+ + +G K+ DFGVSA L S+ +R+T VG Sbjct: 123 YILYGALLGLQHLHCHR-IIHRDVKGNNIPLTTEGGAKLVDFGVSAQLTSTRLRRNTSVG 181 Query: 784 TYNYMAPERIS-----GSSYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEA 948 T +MAPE I+ SSYD + DVWSLG+ +E G PP E + ++L Sbjct: 182 TPFWMAPEVIACEQQYDSSYDARCDVWSLGITAIELGDG----DPPLFE--MHPVKMLFK 235 Query: 949 IVDQPPPS-APADQFSPEFCSFISSCIQKDPAERKSASELLNHAFIKKFEDKDLDLR 1116 I PPP+ D + EF FIS C+ KD +R S + LL+H FIK + K L L+ Sbjct: 236 IPRNPPPTLLHPDSWCEEFNHFISQCLIKDFEKRPSVTHLLDHPFIKGTQGKVLCLQ 292
>Q6C3J2:IPL1_YARLI Spindle assembly checkpoint kinase - Yarrowia lipolytica (Candida| lipolytica) Length = 371 Score = 135 bits (341), Expect = 3e-31 Identities = 86/266 (32%), Positives = 138/266 (51%), Gaps = 2/266 (0%) Frame = +1 Query: 292 SMDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMN--IQESVRKQIVQELKINQAT 465 S+DD E+ + +GKG G V LV+ K G ALK ++ ++ +V KQ +E++I Sbjct: 95 SLDDFEIGKALGKGKFGKVYLVKDKKTGFVSALKCMEKKELVEGNVEKQFRREVEIQSNL 154 Query: 466 QSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLYLH 645 + +++ F+ +YL+LEY+ G L +++ K E + Q+ E LLYLH Sbjct: 155 RHTNVLRLFGHFHDKDRVYLILEYVVHGELYKLLRNQKRFTESTASSYIYQMSEALLYLH 214 Query: 646 HERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISGSS 825 +++IHRDIKP N+L++ +KI+DFG S S+ +R T GT +Y+ PE + Sbjct: 215 G-KNIIHRDIKPENILLHFNDTIKISDFGWSVHAPSN--RRSTLCGTMDYLPPEIVQSRP 271 Query: 826 YDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAPADQFSPEFC 1005 YD DVWSLG+++ E G P+ P G + Y + + + PP AD Sbjct: 272 YDKNVDVWSLGILMYEFLCGAPPFEEPGGA--QATYRRIVKLDLRIPPYVSADA-----A 324 Query: 1006 SFISSCIQKDPAERKSASELLNHAFI 1083 I + DPA+R ++ H +I Sbjct: 325 DLIKRMLTLDPAKRFKLKDMHKHPWI 350
>O14427:CLA4_CANAL Serine/threonine-protein kinase CLA4 - Candida albicans (Yeast)| Length = 971 Score = 135 bits (341), Expect = 3e-31 Identities = 112/356 (31%), Positives = 173/356 (48%), Gaps = 5/356 (1%) Frame = +1 Query: 88 EAMRGKKPLKELTLSVPAQETPVDKFLTASGTFKDGELRLNQRGLQLISEENGDEHQSTK 267 ++ + K+ L E T V +P DK + + + L+ E D K Sbjct: 608 KSSKSKEALNE-TSGVSKTPSPTDKSNKPTAPASGPAVTKTAKQLKKERERLNDLQIIAK 666 Query: 268 MK-VEDVQLSMDDLEMIQVIGKGSGGVVQLVRH-KWVGTFYALKGIQMNIQESVRKQ-IV 438 +K V + Q +++ G+G+ G V L K A+K QM++ RK+ I+ Sbjct: 667 LKTVVNNQDPKPLFRIVEKAGQGASGNVYLAEMIKDNNRKIAIK--QMDLDAQPRKELII 724 Query: 439 QELKINQATQSPHIVLCHQSFY-HNGVIYLVLEYMDRGSLADIIKQVKTIL-EPYLAVLC 612 E+ + + +Q +IV S+ + +++++EYM GSL +II+ L E +A +C Sbjct: 725 NEILVMKDSQHKNIVNFLDSYLIGDNELWVIMEYMQGGSLTEIIENNDFKLNEKQIATIC 784 Query: 613 KQVLEGLLYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYN 792 + L+GL +LH ++H+IHRDIK N+L++ G VKITDFG A L +R T VGT Sbjct: 785 FETLKGLQHLH-KKHIIHRDIKSDNVLLDAYGNVKITDFGFCAKLTDQRNKRATMVGTPY 843 Query: 793 YMAPERISGSSYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPS 972 +MAPE + YD K DVWSLG++ +E G PY E L + P Sbjct: 844 WMAPEVVKQKEYDEKVDVWSLGIMTIEMIEGEPPYLNEE-----PLKALYLIATNGTPKL 898 Query: 973 APADQFSPEFCSFISSCIQKDPAERKSASELLNHAFIKKFEDKDLDLRILVESLEQ 1140 + S F+S C+ D R S ELL H+FI+ K +L L+E +Q Sbjct: 899 KKPELLSNSIKKFLSICLCVDVRYRASTDELLEHSFIQHKSGKIEELAPLLEWKKQ 954
>Q6BVA0:IPL1_DEBHA Spindle assembly checkpoint kinase - Debaryomyces hansenii (Yeast)| (Torulaspora hansenii) Length = 412 Score = 135 bits (339), Expect = 5e-31 Identities = 95/287 (33%), Positives = 149/287 (51%), Gaps = 8/287 (2%) Frame = +1 Query: 247 DEHQSTKMKVEDV-----QLSMDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMN- 408 +E TK+ ++ + +++DD E+ +V+GKG G V V+HK G ALK + Sbjct: 124 NERMDTKLLLQKLPSASRHMTLDDFEIGKVLGKGKLGKVYCVKHKTSGYIAALKVMAKKD 183 Query: 409 -IQESVRKQIVQELKINQATQSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTI 585 I + K +E++I P I + FY + +YL+LEY G L +K + Sbjct: 184 LIDLKLEKNFRREIEIQSNLIHPKISRLYGFFYDHKNVYLILEYSIHGELYHHLKVQRRF 243 Query: 586 LEPYLAVLCKQVLEGLLYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAV-LASSIG 762 + + QV L YLH +H+IHRDIKP N+L++ +K++DFG S L SS Sbjct: 244 NDATASHYIYQVALALDYLH-TKHIIHRDIKPENILLSTDNCIKLSDFGWSVKSLPSSST 302 Query: 763 QRDTFVGTYNYMAPERISGSSYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELL 942 +R T GT +Y+ PE I + +DY D+WSLG++ E +G+ P+ + S Y+ + Sbjct: 303 KRLTICGTLDYLPPEMIESNEHDYTVDIWSLGILCYEFLVGKPPFEEIDKN---STYKRI 359 Query: 943 EAIVDQPPPSAPADQFSPEFCSFISSCIQKDPAERKSASELLNHAFI 1083 A VD PS S E I +QK P +R + +E++NH +I Sbjct: 360 -AKVDLKIPSF----LSSEATDLILRLLQKSPKKRITLAEVMNHPWI 401
>Q6NW76:AURKB_DANRE Serine/threonine-protein kinase 12 - Danio rerio (Zebrafish)| (Brachydanio rerio) Length = 320 Score = 135 bits (339), Expect = 5e-31 Identities = 92/291 (31%), Positives = 151/291 (51%), Gaps = 7/291 (2%) Frame = +1 Query: 235 EENGDEHQST-----KMKVEDVQLSMDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGI 399 E N D H + +K LS+DD ++ + +GKG G V L R + + ALK + Sbjct: 25 EMNPDTHAVSGPGRVPVKSNSKVLSIDDFDIGRPLGKGKFGNVYLARERKLKVVIALKVL 84 Query: 400 --QMNIQESVRKQIVQELKINQATQSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQ 573 ++E V Q+ +E++I + P+I+ + F+ + ++L+LEY RG + +++ Sbjct: 85 FKSQMVKEGVEHQLRREIEIQSHLRHPNILRFYNYFHDDTRVFLILEYAPRGEMYKELQR 144 Query: 574 VKTILEPYLAVLCKQVLEGLLYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLAS 753 + A ++V + L Y H E+ VIHRDIKP NLL+ ++GE+KI DFG S V A Sbjct: 145 YGRFDDQRTATYMEEVSDALQYCH-EKKVIHRDIKPENLLLGYRGELKIADFGWS-VHAP 202 Query: 754 SIGQRDTFVGTYNYMAPERISGSSYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFY 933 S+ +R T GT +Y+ PE I G S+D K D+WS+G++ EC +G P+ E Y Sbjct: 203 SLRRR-TMCGTLDYLPPEMIEGHSHDEKVDLWSIGVLCYECLVGNPPF---ETASHAETY 258 Query: 934 ELLEAIVDQPPPSAPADQFSPEFCSFISSCIQKDPAERKSASELLNHAFIK 1086 + + + Q P S IS ++ P+ R ++ H ++K Sbjct: 259 KRITKVDLQFPKLV-----SEGARDLISKLLRHSPSMRLPLRSVMEHPWVK 304
>Q8K3H5:MYO3A_MOUSE Myosin IIIA - Mus musculus (Mouse)| Length = 1613 Score = 134 bits (338), Expect = 7e-31 Identities = 101/289 (34%), Positives = 157/289 (54%), Gaps = 16/289 (5%) Frame = +1 Query: 298 DDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQIVQELKINQA-TQSP 474 D E+I+ IGKG+ G V V +K G A+K ++ + ++I E I + + P Sbjct: 19 DTWEIIETIGKGTYGKVFKVLNKKSGQKAAVK--ILDPIHDIDEEIEAEYNILRTLSDHP 76 Query: 475 HIVLCHQSFYHNGVI-----YLVLEYMDRGSLADIIK----QVKTILEPYLAVLCKQVLE 627 ++V + ++ I +LVLE + GS+ D++K + + + EP +A + + L Sbjct: 77 NVVRFYGIYFKKDKINGDKLWLVLELCNGGSVTDLVKGFLKRGERMSEPVIAYILHEALM 136 Query: 628 GLLYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPE 807 GL +LH + IHRD+K +N+L+ +G VK+ DFGVSA L+S+ + +T VGT +MAPE Sbjct: 137 GLQHLHSNK-TIHRDVKGNNILLTTEGGVKLVDFGVSAQLSSTRHRLNTSVGTPFWMAPE 195 Query: 808 RIS-----GSSYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPS 972 I+ ++YD + D WSLG+ +E G PP E L L I PPP Sbjct: 196 VIACEQQLDTTYDARCDTWSLGITAIELGDG----DPPLAE--LHPMRALFKIPRNPPPK 249 Query: 973 -APADQFSPEFCSFISSCIQKDPAERKSASELLNHAFIKKFEDKDLDLR 1116 + +S EF FIS C+ KD +R + S+LL H FI + E KD+ L+ Sbjct: 250 LRQPELWSAEFNDFISKCLTKDYEKRPTVSDLLKHKFITQIEGKDVILQ 298
>P70218:M4K1_MOUSE Mitogen-activated protein kinase kinase kinase kinase 1 - Mus| musculus (Mouse) Length = 827 Score = 134 bits (338), Expect = 7e-31 Identities = 93/306 (30%), Positives = 165/306 (53%), Gaps = 3/306 (0%) Frame = +1 Query: 307 EMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQIVQELKINQATQSPHIVL 486 +++Q +G G+ G V R K ALK ++M + V + +E+ + + + +IV Sbjct: 18 DLLQRLGGGTYGEVFKARDKVSKDLVALKMVKMEPDDDVAT-LQKEILMLKTCRHANIVA 76 Query: 487 CHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLYLHHERHVIH 666 H S+ +++ +E+ GSL DI + ++ E ++ +C++VL+GL YLH E+ IH Sbjct: 77 YHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYLHSEKK-IH 135 Query: 667 RDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERIS---GSSYDYK 837 RDIK +N+L+N GEVK+ DFG+SA + +++ +R +F+GT +MAPE + Y+ Sbjct: 136 RDIKGANILINDCGEVKLADFGISAQIGATLARRLSFIGTPYWMAPEVAAVALKGGYNEL 195 Query: 838 SDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAPADQFSPEFCSFIS 1017 D+WSLG+ +E A + P L L+ QPP ++S F +F+ Sbjct: 196 CDIWSLGITAIELAELQPPLFDVHP---LRVLFLMTKSGYQPPRLKEKSRWSSSFHNFVK 252 Query: 1018 SCIQKDPAERKSASELLNHAFIKKFEDKDLDLRILVESLEQPMNVPE*GLPLGEARLCGD 1197 + K+ +R SA+++L+H + + L+ ++++ L++ N P GLP+ D Sbjct: 253 VTLTKNSKKRPSATKMLSHQLVSQ---PGLNRGLILDLLDKMKN-PGKGLPVD----IED 304 Query: 1198 SLPGPP 1215 P PP Sbjct: 305 EEPEPP 310
>Q8C015:PAK7_MOUSE Serine/threonine-protein kinase PAK 7 - Mus musculus (Mouse)| Length = 719 Score = 134 bits (337), Expect = 9e-31 Identities = 82/258 (31%), Positives = 142/258 (55%), Gaps = 3/258 (1%) Frame = +1 Query: 322 IGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQIVQELKINQATQSPHIVLCHQSF 501 IG+GS G+V + K G A+K + + Q+ R+ + E+ I + ++V + S+ Sbjct: 455 IGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQR-RELLFNEVVIMRDYHHDNVVDMYNSY 513 Query: 502 YHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLYLHHERHVIHRDIKP 681 +++V+E+++ G+L DI+ + + E +A +C VL+ L YLH++ VIHRDIK Sbjct: 514 LVGDELWVVMEFLEGGALTDIVTHTR-MNEEQIATVCLSVLKALSYLHNQG-VIHRDIKS 571 Query: 682 SNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISGSSYDYKSDVWSLGL 861 ++L+ G +K++DFG A ++ + +R + VGT +MAPE IS Y + D+WSLG+ Sbjct: 572 DSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGI 631 Query: 862 VILECAIGRFPY--TPPEGEGWLSFYELLEAIVDQPPPSA-PADQFSPEFCSFISSCIQK 1032 +++E G PY PP + + I D PP + S F+ + + Sbjct: 632 MVIEMIDGEPPYFNEPP--------LQAMRRIRDSLPPRVKDLHKVSSMLRGFLDLMLVR 683 Query: 1033 DPAERKSASELLNHAFIK 1086 +P++R +A ELL H F+K Sbjct: 684 EPSQRATAQELLGHPFLK 701
>Q755C4:IPL1_ASHGO Spindle assembly checkpoint kinase - Ashbya gossypii (Yeast)| (Eremothecium gossypii) Length = 367 Score = 134 bits (337), Expect = 9e-31 Identities = 88/287 (30%), Positives = 148/287 (51%), Gaps = 8/287 (2%) Frame = +1 Query: 253 HQSTKMKVEDVQLS------MDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMN-- 408 H++ K + V LS + D E+ +V+GKG G V VRH G ALK ++ Sbjct: 86 HKTGKARAGGVPLSKLQNLKLADFEIGKVLGKGKFGRVYCVRHIESGFVCALKAMEKKDI 145 Query: 409 IQESVRKQIVQELKINQATQSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTIL 588 IQ ++ KQ +E++I + + P++ + F+ +YL++EY+ G L +K Sbjct: 146 IQYNIEKQFRREVEIQSSLRHPNLTQLYGYFHDEKRVYLLMEYLVNGELYKHLKGRSHFN 205 Query: 589 EPYLAVLCKQVLEGLLYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQR 768 + + Q+ + L Y+H ER+++HRDIKP N+++ +K+TDFG S V+ +R Sbjct: 206 DVVASYYVYQMADALDYMH-ERNILHRDIKPENIIIGFNNTIKLTDFGWS-VITPKGSKR 263 Query: 769 DTFVGTYNYMAPERISGSSYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEA 948 T GT +Y++PE I Y+ K DVW+LG++ E +G P+ E L++ +L+ Sbjct: 264 KTLCGTVDYLSPELIRSREYNEKVDVWALGVLTYELLVGSPPFEEESKE--LTYKRILKR 321 Query: 949 IVDQPPPSAPADQFSPEFCSFISSCIQKDPAERKSASELLNHAFIKK 1089 + P D E IS ++ DP +R E+ H +I+K Sbjct: 322 NLIFP------DHVDTEARHLISRLLEYDPGDRIPLKEVKKHPWIEK 362
>Q9P286:PAK7_HUMAN Serine/threonine-protein kinase PAK 7 - Homo sapiens (Human)| Length = 719 Score = 134 bits (336), Expect = 1e-30 Identities = 82/258 (31%), Positives = 141/258 (54%), Gaps = 3/258 (1%) Frame = +1 Query: 322 IGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQIVQELKINQATQSPHIVLCHQSF 501 IG+GS G+V + K G A+K + + Q+ R+ + E+ I + ++V + S+ Sbjct: 455 IGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQR-RELLFNEVVIMRDYHHDNVVDMYSSY 513 Query: 502 YHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLYLHHERHVIHRDIKP 681 +++V+E+++ G+L DI+ + + E +A +C VL L YLH++ VIHRDIK Sbjct: 514 LVGDELWVVMEFLEGGALTDIVTHTR-MNEEQIATVCLSVLRALSYLHNQG-VIHRDIKS 571 Query: 682 SNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISGSSYDYKSDVWSLGL 861 ++L+ G +K++DFG A ++ + +R + VGT +MAPE IS Y + D+WSLG+ Sbjct: 572 DSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGI 631 Query: 862 VILECAIGRFPY--TPPEGEGWLSFYELLEAIVDQPPPSA-PADQFSPEFCSFISSCIQK 1032 +++E G PY PP + + I D PP + S F+ + + Sbjct: 632 MVIEMIDGEPPYFNEPP--------LQAMRRIRDSLPPRVKDLHKVSSVLRGFLDLMLVR 683 Query: 1033 DPAERKSASELLNHAFIK 1086 +P++R +A ELL H F+K Sbjct: 684 EPSQRATAQELLGHPFLK 701
>Q9UQB9:AURKC_HUMAN Serine/threonine-protein kinase 13 - Homo sapiens (Human)| Length = 309 Score = 134 bits (336), Expect = 1e-30 Identities = 88/269 (32%), Positives = 142/269 (52%), Gaps = 2/269 (0%) Frame = +1 Query: 286 QLSMDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNI--QESVRKQIVQELKINQ 459 +L++DD E+ + +GKG G V L R K ALK + + +E + Q+ +E++I Sbjct: 37 RLTVDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQA 96 Query: 460 ATQSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLY 639 Q P+I+ + F+ +YL+LEY RG L +++ + + E A + +++ + L Y Sbjct: 97 HLQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTY 156 Query: 640 LHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISG 819 H ++ VIHRDIKP NLL+ +GEVKI DFG S S +R T GT +Y+ PE I G Sbjct: 157 CH-DKKVIHRDIKPENLLLGFRGEVKIADFGWSVHTPSL--RRKTMCGTLDYLPPEMIEG 213 Query: 820 SSYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAPADQFSPE 999 +YD K D+W +G++ E +G Y P E Y + + + P S P Sbjct: 214 RTYDEKVDLWCIGVLCYELLVG---YPPFESASHSETYRRILKVDVRFPLSMPLGA---- 266 Query: 1000 FCSFISSCIQKDPAERKSASELLNHAFIK 1086 IS ++ P ER +++L H +++ Sbjct: 267 -RDLISRLLRYQPLERLPLAQILKHPWVQ 294
>O64629:AUR3_ARATH Serine/threonine-protein kinase Aurora-3 - Arabidopsis thaliana| (Mouse-ear cress) Length = 288 Score = 134 bits (336), Expect = 1e-30 Identities = 92/273 (33%), Positives = 140/273 (51%), Gaps = 2/273 (0%) Frame = +1 Query: 286 QLSMDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQES--VRKQIVQELKINQ 459 Q S+ D E+ + +GKG G V L R ALK I E + Q+ +E++I Sbjct: 16 QWSLADFEIGRPLGKGKFGRVYLAREAKSKYIVALKVIFKEQIEKYKIHHQLRREMEIQT 75 Query: 460 ATQSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLY 639 + + P+I+ F+ N I+L+LEY G L ++KQ + E A + + L Y Sbjct: 76 SLRHPNILRLFGWFHDNERIFLILEYAHGGELYGVLKQNGHLTEQQAATYIASLSQALAY 135 Query: 640 LHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISG 819 H + VIHRDIKP NLL++H+G +KI DFG S S +R T GT +Y+APE + Sbjct: 136 CHG-KCVIHRDIKPENLLLDHEGRLKIADFGWS---VQSSNKRKTMCGTLDYLAPEMVEN 191 Query: 820 SSYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAPADQFSPE 999 +DY D W+LG++ E G P+ + +F +L+ +D P P S E Sbjct: 192 RDHDYAVDNWTLGILCYEFLYGNPPFEAESQKD--TFKRILK--IDLSFPLTP--NVSEE 245 Query: 1000 FCSFISSCIQKDPAERKSASELLNHAFIKKFED 1098 + IS + KDP++R S +++ H +I K D Sbjct: 246 AKNLISQLLVKDPSKRLSIEKIMQHPWIVKNAD 278
>Q01314:AKT1_BOVIN RAC-alpha serine/threonine-protein kinase - Bos taurus (Bovine)| Length = 480 Score = 134 bits (336), Expect = 1e-30 Identities = 93/335 (27%), Positives = 163/335 (48%), Gaps = 14/335 (4%) Frame = +1 Query: 145 ETPVDK--FLTASGTFKDGELRLNQRGLQLIS----EENGDEHQSTKMKVEDVQLSMDDL 306 ETP ++ + TA T DG R + + S E +G E + +++M+D Sbjct: 91 ETPEEREEWTTAIQTVADGLKRQEEETMDFRSGSPGENSGAEEMEVSLAKPKHRVTMNDF 150 Query: 307 EMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNI---QESVRKQIVQELKINQATQSPH 477 E ++++GKG+ G V LV+ K G +YA+K ++ + ++ V + + ++ Q ++ P Sbjct: 151 EYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTEN-RVLQNSRHPF 209 Query: 478 IVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLYLHHERH 657 + SF + + V+EY + G L + + + E +++ L YLH E+ Sbjct: 210 LTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKE 269 Query: 658 VIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISGSSYDYK 837 V++RD+K NL+++ G +KITDFG+ TF GT Y+APE + + Y Sbjct: 270 VVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRA 329 Query: 838 SDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAPADQFSPEFCSFIS 1017 D W LG+V+ E GR P+ + E +EL+ + P + SPE S +S Sbjct: 330 VDWWGLGVVMYEMMCGRLPFYNQDHE---KLFELILMEEIRFPRT-----LSPEAKSLLS 381 Query: 1018 SCIQKDPAER-----KSASELLNHAFIKKFEDKDL 1107 ++KDP +R + A E++ H F +D+ Sbjct: 382 GLLKKDPKQRLGGGSEDAKEIMQHRFFASIVWQDV 416
>Q8WXR4:MYO3B_HUMAN Myosin-IIIB - Homo sapiens (Human)| Length = 1341 Score = 133 bits (335), Expect = 2e-30 Identities = 103/289 (35%), Positives = 159/289 (55%), Gaps = 16/289 (5%) Frame = +1 Query: 298 DDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQIVQELKINQATQS-P 474 D E+I+ IGKG+ G V V +K G+ A+K ++ + ++I E I Q + P Sbjct: 25 DTWEIIETIGKGTYGKVYKVTNKRDGSLAAVK--ILDPVSDMDEEIEAEYNILQFLPNHP 82 Query: 475 HIVLCHQSFYH-----NGVIYLVLEYMDRGSLADIIKQV----KTILEPYLAVLCKQVLE 627 ++V + FY G ++LVLE + GS+ +++K + + + E ++ + L Sbjct: 83 NVVKFYGMFYKADHCVGGQLWLVLELCNGGSVTELVKGLLRCGQRLDEAMISYILYGALL 142 Query: 628 GLLYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPE 807 GL +LH+ R +IHRD+K +N+L+ +G VK+ DFGVSA L S+ +R+T VGT +MAPE Sbjct: 143 GLQHLHNNR-IIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRLRRNTSVGTPFWMAPE 201 Query: 808 RIS-----GSSYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPS 972 I+ SSYD + DVWSLG+ +E G PP + + + L I PPP+ Sbjct: 202 VIACEQQYDSSYDARCDVWSLGITAIELGDG----DPPLFD--MHPVKTLFKIPRNPPPT 255 Query: 973 -APADQFSPEFCSFISSCIQKDPAERKSASELLNHAFIKKFEDKDLDLR 1116 +++ EF FIS C+ KD R S + LL+H FIK K L L+ Sbjct: 256 LLHPEKWCEEFNHFISQCLIKDFERRPSVTHLLDHPFIKGVHGKVLFLQ 304
>Q9R0G8:NRK_MOUSE Nik-related protein kinase - Mus musculus (Mouse)| Length = 1455 Score = 132 bits (333), Expect = 3e-30 Identities = 93/311 (29%), Positives = 166/311 (53%), Gaps = 38/311 (12%) Frame = +1 Query: 316 QVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQIVQELKINQATQS-------- 471 + IG G+ G + L H+ G+ A+K M+ +++ +I + +++N+ +S Sbjct: 29 KAIGLGTYGRIFLGIHEKTGSLVAVK--VMSARKTPLPEIGRRVRVNKYQKSVGWRYSDE 86 Query: 472 -----------------PHIVLCHQSFY------HNGVIYLVLEYMDRGSLADIIKQVK- 579 +IV + +F+ H +++V+E GS+ D+++ + Sbjct: 87 EEDLRTELNLLRKYSFHKNIVTFYGAFFKLNPPGHQHQLWMVMELCAAGSVTDVVRMTRN 146 Query: 580 -TILEPYLAVLCKQVLEGLLYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASS 756 ++ E ++A +C+++L+GL +LH + VIHRDIK N+L+ H EVKI DFGVSA ++ + Sbjct: 147 QSLKEDWIAYICREILQGLAHLHAHQ-VIHRDIKGQNVLLTHDAEVKIVDFGVSAQVSRT 205 Query: 757 IGQRDTFVGTYNYMAPERI-----SGSSYDYKSDVWSLGLVILECAIGRFPYTPPEGEGW 921 G+R++F+GT +MAPE I SYDY+SDVWS+G+ +E A G P Sbjct: 206 NGRRNSFIGTPYWMAPEVIHCDEDPRCSYDYRSDVWSVGITAIEMAEGAPPLCK------ 259 Query: 922 LSFYELLEAIVDQPPPSAPADQFSPEFCSFISSCIQKDPAERKSASELLNHAFIKKFEDK 1101 L E L I+ + P + +S +F +F+ +C+ K+ R ++ +L H F+ +++ Sbjct: 260 LQPLEALCVILREAAPKVKSSGWSRKFQNFMENCMIKNFLFRPTSGNMLLHPFVHDIKNE 319 Query: 1102 DLDLRILVESL 1134 R +VESL Sbjct: 320 ----RRVVESL 326
>Q17850:PAK1_CAEEL Serine/threonine-protein kinase pak-1 - Caenorhabditis elegans| Length = 572 Score = 132 bits (332), Expect = 4e-30 Identities = 87/259 (33%), Positives = 139/259 (53%), Gaps = 1/259 (0%) Frame = +1 Query: 313 IQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQ-IVQELKINQATQSPHIVLC 489 + IG G+ G V A+K QMN+++ +K+ I+ E+ + + + +IV Sbjct: 298 VDKIGSGASGSVYTAIEISTEAEVAIK--QMNLKDQPKKELIINEILVMRENKHANIVNY 355 Query: 490 HQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLYLHHERHVIHR 669 S+ +++V+EY+ GSL D++ + + + + +A +C++VL+ L +LH RHVIHR Sbjct: 356 LDSYLVCDELWVVMEYLAGGSLTDVVTECQ-MEDGIIAAVCREVLQALEFLH-SRHVIHR 413 Query: 670 DIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISGSSYDYKSDVW 849 DIK N+L+ G VK+TDFG A L+ +R T VGT +MAPE ++ Y K DVW Sbjct: 414 DIKSDNILLGMDGSVKLTDFGFCAQLSPEQRKRTTMVGTPYWMAPEVVTRKQYGPKVDVW 473 Query: 850 SLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAPADQFSPEFCSFISSCIQ 1029 SLG++ +E G PY E L L+ + P D + F F+ S ++ Sbjct: 474 SLGIMAIEMVEGEPPYL---NENPLRAIYLI--ATNGKPDFPGRDSMTLLFKDFVDSALE 528 Query: 1030 KDPAERKSASELLNHAFIK 1086 R SAS+LL H F++ Sbjct: 529 VQVENRWSASQLLTHPFLR 547
>P51956:NEK3_HUMAN Serine/threonine-protein kinase Nek3 - Homo sapiens (Human)| Length = 506 Score = 132 bits (332), Expect = 4e-30 Identities = 88/284 (30%), Positives = 148/284 (52%), Gaps = 2/284 (0%) Frame = +1 Query: 295 MDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQIVQELKINQATQSP 474 MDD ++++IG+GS G LV+H+ +A+K I++ S + +E + + P Sbjct: 1 MDDYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRKEAVLLAKMKHP 60 Query: 475 HIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVL--CKQVLEGLLYLHH 648 +IV +SF G +Y+V+EY D G L IKQ K L P +L Q+ G+ ++H Sbjct: 61 NIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIHK 120 Query: 649 ERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISGSSY 828 +R V+HRDIK N+ + G+VK+ DFG + +L++ + T+VGT Y+ PE Y Sbjct: 121 KR-VLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPY 179 Query: 829 DYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAPADQFSPEFCS 1008 + KSD+WSLG ++ E + P+ + W + + P PS +S E Sbjct: 180 NNKSDIWSLGCILYELCTLKHPF---QANSWKNLILKVCQGCISPLPS----HYSYELQF 232 Query: 1009 FISSCIQKDPAERKSASELLNHAFIKKFEDKDLDLRILVESLEQ 1140 + +++P+ R SA+ LL+ + + K L I++E E+ Sbjct: 233 LVKQMFKRNPSHRPSATTLLSRGIVARLVQKCLPPEIIMEYGEE 276
>Q9HFW2:CLA4_ASHGO Serine/threonine-protein kinase CLA4 - Ashbya gossypii (Yeast)| (Eremothecium gossypii) Length = 793 Score = 132 bits (332), Expect = 4e-30 Identities = 91/285 (31%), Positives = 143/285 (50%), Gaps = 25/285 (8%) Frame = +1 Query: 307 EMIQVIGKGSGGVVQLVRHKWVGTFYALKGI----------------QMNIQESVRKQ-I 435 +MI+ G+G+ G V L + + + G+ QM + + RK+ I Sbjct: 499 QMIEKAGQGASGSVYLAQRLKIPPYDENSGVSQHELNDNIGDKVAIKQMILSKQPRKELI 558 Query: 436 VQELKINQATQSPHIVLCHQSFYHN-GVIYLVLEYMDRGSLADIIKQV-------KTILE 591 V E+ + + +Q +IV +++ +++V+EYM+ GSL D+I+ + E Sbjct: 559 VNEILVMKDSQHKNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDVIENSIGSDASESPMTE 618 Query: 592 PYLAVLCKQVLEGLLYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRD 771 P +A + ++ +GL +LH ++H+IHRDIK N+L++ G VKITDFG A L +R Sbjct: 619 PQIAYIVRETCQGLKFLH-DKHIIHRDIKSDNVLLDTHGRVKITDFGFCAKLTDKRSKRA 677 Query: 772 TFVGTYNYMAPERISGSSYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAI 951 T VGT +MAPE + YD K DVWSLG++ +E G PY E L Sbjct: 678 TMVGTPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLEGEPPYLNEE-----PLKALYLIA 732 Query: 952 VDQPPPSAPADQFSPEFCSFISSCIQKDPAERKSASELLNHAFIK 1086 + P + S E F+S C+ D R S ELL+H+F + Sbjct: 733 TNGTPKLKHPELLSLEIKRFLSVCLCVDVRYRASTEELLHHSFFE 777
>P59241:STK6_RAT Serine/threonine-protein kinase 6 - Rattus norvegicus (Rat)| Length = 397 Score = 132 bits (331), Expect = 5e-30 Identities = 107/353 (30%), Positives = 175/353 (49%), Gaps = 9/353 (2%) Frame = +1 Query: 70 PSHSKEEAMRGKKPLKELTLSVPAQETPVDKFL-TASGTFKDGELRLNQRGLQ---LISE 237 PS+S+ + +KP+ A + PV K L ASG L Q+ Q S Sbjct: 49 PSNSQRVPPQAQKPV--------AGQKPVLKQLPAASGPRPASRLSNPQKSEQPQPAASG 100 Query: 238 ENGDEHQSTKMKVEDV---QLSMDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGI-QM 405 N ++ Q++ K ED Q +++D ++ + +GKG G V L R K ALK + ++ Sbjct: 101 NNSEKEQTSIQKTEDSKKRQWTLEDFDIGRPLGKGKFGNVYLAREKQSKFILALKVLFKV 160 Query: 406 NIQES-VRKQIVQELKINQATQSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKT 582 ++++ V Q+ +E++I + P+I+ + F+ +YL+LEY G++ ++++ Sbjct: 161 QLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSK 220 Query: 583 ILEPYLAVLCKQVLEGLLYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIG 762 E A ++ L Y H +R VIHRDIKP NLL+ GE+KI DFG S SS Sbjct: 221 FDEQRTATYITELANALSYCHSKR-VIHRDIKPENLLLGSNGELKIADFGWSVHAPSS-- 277 Query: 763 QRDTFVGTYNYMAPERISGSSYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELL 942 +R T GT +Y PE I G +D K D+WSLG++ E +G P+ E + Y + Sbjct: 278 RRTTLCGTLDYQPPEMIEGRMHDEKVDLWSLGVLCYEFLVGMPPF---EAHTYQETYRRI 334 Query: 943 EAIVDQPPPSAPADQFSPEFCSFISSCIQKDPAERKSASELLNHAFIKKFEDK 1101 + P D + IS ++ + ++R + +E+L H +IK K Sbjct: 335 SRVEFTFP-----DFVTEGARDLISRLLKHNSSQRLTLAEVLEHPWIKANSSK 382
>Q59S66:IPL1_CANAL Spindle assembly checkpoint kinase - Candida albicans (Yeast)| Length = 530 Score = 132 bits (331), Expect = 5e-30 Identities = 98/354 (27%), Positives = 163/354 (46%), Gaps = 25/354 (7%) Frame = +1 Query: 115 KELTLSVPAQETPVDKFLTASGTFKDGELRLNQRGLQLISEENGDEHQSTKMKVEDVQLS 294 K T + Q T +K L S +R + S S QL+ Sbjct: 183 KRRTTTTATQNTNNNKILNPS--LSSSTIRFSTVSSSTSSSTTSSSSSSHTSPKPQQQLT 240 Query: 295 MDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQ----MNIQESVRKQIVQELKINQA 462 +DD E +++GKG G V V+HK G +ALK + MN++ + K + +E++I Sbjct: 241 LDDFEFGKILGKGKLGRVYCVKHKQSGLIFALKVMSKSEIMNLK--LEKSLRREIEIQSN 298 Query: 463 TQSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLYL 642 +I + F+ + IYL+LEY G L +K++K + Q+ + L++L Sbjct: 299 LYHINITRLYSWFHDSINIYLLLEYSIEGELYTHLKKLKRFDNIMASNYIFQITQALIFL 358 Query: 643 HHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQ------------------- 765 H +R +IHRD+KP N++++ ++K++DFG S + + Q Sbjct: 359 H-QRGIIHRDLKPENIMISLDNQLKLSDFGWSVQINQNQNQNQIHNQTQTQKTPHQKKQK 417 Query: 766 --RDTFVGTYNYMAPERISGSSYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYEL 939 R T GT +Y+ PE I S+D+ D+W+LG++ E +G+ P+ E YE Sbjct: 418 QKRLTICGTLDYLPPEMIESKSHDFSVDIWALGILCYELLVGKPPF---EAINRNITYEK 474 Query: 940 LEAIVDQPPPSAPADQFSPEFCSFISSCIQKDPAERKSASELLNHAFIKKFEDK 1101 + + + P + D IS + KDP +R S E+LNH +I K + K Sbjct: 475 IAKVDIKYPSNLDVDAI-----DLISKLVVKDPNKRLSLKEVLNHNWIIKNKPK 523
>Q6CWQ4:IPL1_KLULA Spindle assembly checkpoint kinase - Kluyveromyces lactis (Yeast)| (Candida sphaerica) Length = 361 Score = 130 bits (328), Expect = 1e-29 Identities = 79/267 (29%), Positives = 142/267 (53%), Gaps = 2/267 (0%) Frame = +1 Query: 289 LSMDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMN--IQESVRKQIVQELKINQA 462 +++ D E+ +++GKG G V V+H+ G ALK ++ +Q +++KQ +E++I + Sbjct: 95 MTLQDFEIGKILGKGKFGKVYCVKHRETGLICALKAMEKKEIVQYTIQKQFRREVEIQGS 154 Query: 463 TQSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLYL 642 + ++ + FY +YL++EY+ G L +K + E + Q+ L Y+ Sbjct: 155 FKHKNLTQLYGFFYDEKRVYLLMEYVYYGELYKFLKNNGPLNETLASYFVYQMANALDYM 214 Query: 643 HHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISGS 822 H ++++HRDIKP N+L+ +K+TDFG S V +R T GT +Y++PE I Sbjct: 215 H-SKNILHRDIKPENILIGFNNTIKLTDFGWS-VYNEDGQKRKTLCGTIDYLSPELIKSR 272 Query: 823 SYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAPADQFSPEF 1002 Y+ K DVW+LG++ E +G P+ E +++ +L + P SP+ Sbjct: 273 EYNNKVDVWALGVLTYELLVGSPPFEEDTKE--MTYRRILRCDLKFPL------NVSPQA 324 Query: 1003 CSFISSCIQKDPAERKSASELLNHAFI 1083 I +Q +P++R SE+ +HA+I Sbjct: 325 RDLIVRLLQFEPSKRIPLSEVKSHAWI 351
>P31750:AKT1_MOUSE RAC-alpha serine/threonine-protein kinase - Mus musculus (Mouse)| Length = 480 Score = 130 bits (328), Expect = 1e-29 Identities = 92/335 (27%), Positives = 164/335 (48%), Gaps = 14/335 (4%) Frame = +1 Query: 145 ETPVDK--FLTASGTFKDGELRLNQRGLQLISEENGDEHQSTKMKVEDVQ----LSMDDL 306 ETP ++ + TA T DG R + + S D + +M+V + ++M++ Sbjct: 91 ETPEEREEWATAIQTVADGLKRQEEETMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEF 150 Query: 307 EMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNI---QESVRKQIVQELKINQATQSPH 477 E ++++GKG+ G V LV+ K G +YA+K ++ + ++ V + + ++ Q ++ P Sbjct: 151 EYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTEN-RVLQNSRHPF 209 Query: 478 IVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLYLHHERH 657 + SF + + V+EY + G L + + + E +++ L YLH E++ Sbjct: 210 LTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKN 269 Query: 658 VIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISGSSYDYK 837 V++RD+K NL+++ G +KITDFG+ TF GT Y+APE + + Y Sbjct: 270 VVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRA 329 Query: 838 SDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAPADQFSPEFCSFIS 1017 D W LG+V+ E GR P+ + E +L E I+ + A PE S +S Sbjct: 330 VDWWGLGVVMYEMMCGRLPFYNQDHE------KLFELILME--EIAFPRTLGPEAKSLLS 381 Query: 1018 SCIQKDPAER-----KSASELLNHAFIKKFEDKDL 1107 ++KDP +R + A E++ H F +D+ Sbjct: 382 GLLKKDPTQRLGGGSEDAKEIMQHRFFANIVWQDV 416
>Q91819:STK6L_XENLA Serine/threonine-protein kinase Eg2-like - Xenopus laevis (African| clawed frog) Length = 408 Score = 130 bits (327), Expect = 1e-29 Identities = 92/288 (31%), Positives = 144/288 (50%), Gaps = 2/288 (0%) Frame = +1 Query: 232 SEENGDEHQSTKMKVEDVQLSMDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNI 411 S + G K + + Q ++D E+ + +GKG G V L R + ALK + + Sbjct: 116 STDQGKTLAVPKEEGKKKQWCLEDFEIGRPLGKGKFGNVYLARERESKFILALKVLFKSQ 175 Query: 412 QES--VRKQIVQELKINQATQSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTI 585 E V Q+ +E++I + P+I+ + F+ +YL+L+Y G L +++ Sbjct: 176 LEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDASRVYLILDYAPGGELFRELQKCTRF 235 Query: 586 LEPYLAVLCKQVLEGLLYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQ 765 + A+ KQ+ E LLY H ++ VIHRDIKP NLL+ GE+KI DFG S SS + Sbjct: 236 DDQRSALYIKQLAEALLYCHSKK-VIHRDIKPENLLLGSNGELKIADFGWSVHAPSS--R 292 Query: 766 RDTFVGTYNYMAPERISGSSYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLE 945 R T GT +Y+ PE I G +D K D+WSLG++ E +G+ P+ E + Y + Sbjct: 293 RTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPF---ETDTHQETYRRIS 349 Query: 946 AIVDQPPPSAPADQFSPEFCSFISSCIQKDPAERKSASELLNHAFIKK 1089 + Q PP S E +S ++ +P R +L H +I K Sbjct: 350 KVEFQYPP-----YVSEEAKDLVSKLLKHNPNHRLPLKGVLEHPWIVK 392
>Q6FV07:IPL1_CANGA Spindle assembly checkpoint kinase - Candida glabrata (Yeast)| (Torulopsis glabrata) Length = 358 Score = 130 bits (327), Expect = 1e-29 Identities = 84/270 (31%), Positives = 141/270 (52%), Gaps = 2/270 (0%) Frame = +1 Query: 286 QLSMDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMN--IQESVRKQIVQELKINQ 459 +LS+ D E+ + +GKG G V VRHK G ALK I+ N +Q ++ KQ+ +E+ I Sbjct: 94 KLSLKDFEVGRKLGKGKFGKVYCVRHKKSGFICALKAIEKNEILQFNLLKQLKREVDIQL 153 Query: 460 ATQSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLY 639 P+I+ + F+ +YL++E+ G L +K + + Q+ + L Y Sbjct: 154 GMDHPNIIKLYAHFHDEKRVYLLMEHSINGELYKSLKNNGPFNDVLASHYIYQIADALHY 213 Query: 640 LHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISG 819 +H +R +IHRD+KP N+L+ VK+ DFG S +L +R T GT +Y++PE I+ Sbjct: 214 MHKKR-IIHRDVKPENVLIGFDNVVKLADFGWS-ILNPEGSKRKTLCGTIDYLSPEMITP 271 Query: 820 SSYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAPADQFSPE 999 YD + DVW+LG++ E +G P+ E L++ +L+ ++ P + S + Sbjct: 272 REYDEQVDVWALGVLAYELVVGVPPF--EENSKELTYKRILKCDLNFP------ESISKD 323 Query: 1000 FCSFISSCIQKDPAERKSASELLNHAFIKK 1089 IS + D +R S + + H +I K Sbjct: 324 AKDLISKLLVTDTTQRLSLTGVKTHPWILK 353
>P31748:AKT_MLVAT AKT kinase-transforming protein - AKT8 murine leukemia virus| Length = 501 Score = 130 bits (327), Expect = 1e-29 Identities = 91/335 (27%), Positives = 164/335 (48%), Gaps = 14/335 (4%) Frame = +1 Query: 145 ETPVDK--FLTASGTFKDGELRLNQRGLQLISEENGDEHQSTKMKVEDVQ----LSMDDL 306 ETP ++ + TA T DG R + + S D + +M+V + ++M++ Sbjct: 112 ETPEEREEWATAIQTVADGLKRQEEETMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEF 171 Query: 307 EMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNI---QESVRKQIVQELKINQATQSPH 477 E ++++GKG+ G V LV+ K G +YA+K ++ + ++ V + + ++ Q ++ P Sbjct: 172 EYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTEN-RVLQNSRHPF 230 Query: 478 IVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLYLHHERH 657 + SF + + V+EY + G L + + + E +++ L YLH E++ Sbjct: 231 LTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKN 290 Query: 658 VIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISGSSYDYK 837 V++RD+K NL+++ G +KITDFG+ TF GT Y+APE + + Y Sbjct: 291 VVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRA 350 Query: 838 SDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAPADQFSPEFCSFIS 1017 D W LG+V+ E GR P+ + E +EL+ + P + PE S +S Sbjct: 351 VDWWGLGVVMYEMMCGRLPFYNQDHE---KLFELILMEEIRFPRT-----LGPEAKSLLS 402 Query: 1018 SCIQKDPAER-----KSASELLNHAFIKKFEDKDL 1107 ++KDP +R + A E++ H F +D+ Sbjct: 403 GLLKKDPTQRLGGGSEDAKEIMQHRFFANIVWQDV 437
>Q96GD4:AURKB_HUMAN Serine/threonine-protein kinase 12 - Homo sapiens (Human)| Length = 344 Score = 130 bits (326), Expect = 2e-29 Identities = 88/267 (32%), Positives = 142/267 (53%), Gaps = 2/267 (0%) Frame = +1 Query: 292 SMDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNI--QESVRKQIVQELKINQAT 465 ++DD E+ + +GKG G V L R K ALK + + +E V Q+ +E++I Sbjct: 73 TIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHL 132 Query: 466 QSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLYLH 645 P+I+ + FY IYL+LEY RG L +++ T E A + +++ + L+Y H Sbjct: 133 HHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCH 192 Query: 646 HERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISGSS 825 ++ VIHRDIKP NLL+ KGE+KI DFG S V A S+ +R T GT +Y+ PE I G Sbjct: 193 GKK-VIHRDIKPENLLLGLKGELKIADFGWS-VHAPSL-RRKTMCGTLDYLPPEMIEGRM 249 Query: 826 YDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAPADQFSPEFC 1005 ++ K D+W +G++ E +G P+ E Y + + + P S P Sbjct: 250 HNEKVDLWCIGVLCYELLVGNPPF---ESASHNETYRRIVKVDLKFPASVPTGA-----Q 301 Query: 1006 SFISSCIQKDPAERKSASELLNHAFIK 1086 IS ++ +P+ER +++ H +++ Sbjct: 302 DLISKLLRHNPSERLPLAQVSAHPWVR 328
>P47196:AKT1_RAT RAC-alpha serine/threonine-protein kinase - Rattus norvegicus (Rat)| Length = 480 Score = 130 bits (326), Expect = 2e-29 Identities = 91/335 (27%), Positives = 164/335 (48%), Gaps = 14/335 (4%) Frame = +1 Query: 145 ETPVDK--FLTASGTFKDGELRLNQRGLQLISEENGDEHQSTKMKVEDVQ----LSMDDL 306 ETP ++ + TA T DG R + + S D + +M+V + ++M++ Sbjct: 91 ETPEEREEWTTAIQTVADGLKRQEEETMDFRSGSPSDNSGAEEMEVALAKPKHRVTMNEF 150 Query: 307 EMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNI---QESVRKQIVQELKINQATQSPH 477 E ++++GKG+ G V LV+ K G +YA+K ++ + ++ V + + ++ Q ++ P Sbjct: 151 EYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTEN-RVLQNSRHPF 209 Query: 478 IVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLYLHHERH 657 + SF + + V+EY + G L + + + E +++ L YLH E++ Sbjct: 210 LTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKN 269 Query: 658 VIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISGSSYDYK 837 V++RD+K NL+++ G +KITDFG+ TF GT Y+APE + + Y Sbjct: 270 VVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRA 329 Query: 838 SDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAPADQFSPEFCSFIS 1017 D W LG+V+ E GR P+ + E +EL+ + P + PE S +S Sbjct: 330 VDWWGLGVVMYEMMCGRLPFYNQDHE---KLFELILMEEIRFPRT-----LGPEAKSLLS 381 Query: 1018 SCIQKDPAER-----KSASELLNHAFIKKFEDKDL 1107 ++KDP +R + A E++ H F +D+ Sbjct: 382 GLLKKDPTQRLGGGSEDAKEIMQHRFFANIVWQDV 416
>O14965:STK6_HUMAN Serine/threonine-protein kinase 6 - Homo sapiens (Human)| Length = 403 Score = 129 bits (325), Expect = 2e-29 Identities = 91/288 (31%), Positives = 151/288 (52%), Gaps = 5/288 (1%) Frame = +1 Query: 235 EENGDEHQSTKMKVEDV---QLSMDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGI-Q 402 E N +E ++K K E+ Q +++D E+ + +GKG G V L R K ALK + + Sbjct: 107 ENNPEEELASKQKNEESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFK 166 Query: 403 MNIQES-VRKQIVQELKINQATQSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVK 579 ++++ V Q+ +E++I + P+I+ + F+ +YL+LEY G++ ++++ Sbjct: 167 AQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLS 226 Query: 580 TILEPYLAVLCKQVLEGLLYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSI 759 E A ++ L Y H +R VIHRDIKP NLL+ GE+KI DFG S SS Sbjct: 227 KFDEQRTATYITELANALSYCHSKR-VIHRDIKPENLLLGSAGELKIADFGWSVHAPSS- 284 Query: 760 GQRDTFVGTYNYMAPERISGSSYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYEL 939 +R T GT +Y+ PE I G +D K D+WSLG++ E +G+ P+ E + Y+ Sbjct: 285 -RRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPF---EANTYQETYKR 340 Query: 940 LEAIVDQPPPSAPADQFSPEFCSFISSCIQKDPAERKSASELLNHAFI 1083 + + P D + IS ++ +P++R E+L H +I Sbjct: 341 ISRVEFTFP-----DFVTEGARDLISRLLKHNPSQRPMLREVLEHPWI 383
>Q75DK7:STE20_ASHGO Serine/threonine-protein kinase STE20 - Ashbya gossypii (Yeast)| (Eremothecium gossypii) Length = 971 Score = 129 bits (325), Expect = 2e-29 Identities = 97/325 (29%), Positives = 158/325 (48%), Gaps = 15/325 (4%) Frame = +1 Query: 109 PLKELTLSVPAQETPVDKF--------LTASGTFKDGELRLNQRGLQLISEENGDEHQST 264 P K + S+PA TP L + + Q L+ EE +Q Sbjct: 607 PSKSIPPSLPAVPTPPPPIEKDPPLRDLEREREREHSSAKQGQLALERKREEKRRRNQKL 666 Query: 265 KMKVEDVQLSMDDLEMIQ---VIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQ- 432 + K+ ++ D ++ + IG+G+ G V A+K QMN+++ +K+ Sbjct: 667 QAKLAEICSPGDPSKIYRNLVKIGQGASGGVYTAYEIGTNASVAIK--QMNLEKQPKKEL 724 Query: 433 IVQELKINQATQSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLC 612 I+ E+ + + ++ +IV S+ G +++++EYM+ GSL D++ + E +A + Sbjct: 725 IINEILVMKGSRHNNIVNFIDSYLLKGDLWVIMEYMEGGSLTDVVTHC-ILTEGQIAAVS 783 Query: 613 KQVLEGLLYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYN 792 ++ L GL +LH + VIHRDIK N+L++ G +K+TDFG A + + +R T VGT Sbjct: 784 RETLRGLHFLH-SKGVIHRDIKSDNILLSMDGNIKLTDFGFCAQINETNLKRTTMVGTPY 842 Query: 793 YMAPERISGSSYDYKSDVWSLGLVILECAIGRFPY---TPPEGEGWLSFYELLEAIVDQP 963 +MAPE +S Y K D+WSLG++I+E G PY TP L + Sbjct: 843 WMAPEVVSRKEYGPKVDIWSLGIMIIEMIEGEPPYLNETP--------LRALYLIATNGT 894 Query: 964 PPSAPADQFSPEFCSFISSCIQKDP 1038 P AD SP F F+S +Q P Sbjct: 895 PKLKDADSLSPVFKRFLSWGLQSQP 919
>Q2TA06:STK6_BOVIN Serine/threonine-protein kinase 6 - Bos taurus (Bovine)| Length = 402 Score = 129 bits (324), Expect = 3e-29 Identities = 89/286 (31%), Positives = 150/286 (52%), Gaps = 5/286 (1%) Frame = +1 Query: 241 NGDEHQSTKMKVEDV---QLSMDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGI-QMN 408 N ++ ++K K E+ Q +++D E+ + +GKG G V L R K ALK + + Sbjct: 109 NPEKEVASKQKNEESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQ 168 Query: 409 IQES-VRKQIVQELKINQATQSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTI 585 ++++ V Q+ +E++I + P+I+ + F+ +YL+LEY G++ ++++ Sbjct: 169 LEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGAVYRELQKLSKF 228 Query: 586 LEPYLAVLCKQVLEGLLYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQ 765 E A ++ L Y H +R VIHRDIKP NLL+ GE+KI DFG S SS + Sbjct: 229 DEQRTATYITELANALSYCHSKR-VIHRDIKPENLLLGSAGELKIADFGWSVHAPSS--R 285 Query: 766 RDTFVGTYNYMAPERISGSSYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLE 945 R T GT +Y+ PE I G +D K D+WSLG++ E +G+ P+ E + + Y + Sbjct: 286 RTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPF---EADTYQETYRRIS 342 Query: 946 AIVDQPPPSAPADQFSPEFCSFISSCIQKDPAERKSASELLNHAFI 1083 + P P IS ++ +P++R + E+L H +I Sbjct: 343 RVEFTFPDCVPEGA-----RDLISRLLKHNPSQRPTLKEVLEHPWI 383
>P48562:CLA4_YEAST Serine/threonine-protein kinase CLA4 - Saccharomyces cerevisiae| (Baker's yeast) Length = 842 Score = 129 bits (324), Expect = 3e-29 Identities = 99/311 (31%), Positives = 155/311 (49%), Gaps = 32/311 (10%) Frame = +1 Query: 271 KVEDVQLSMDDLEMIQVI---GKGSGGVVQL-------------------VRHKWVGTFY 384 K++ V ++ D + +VI G+G+ G V L + VG Sbjct: 532 KLKKVTVNADPSQCFKVIEKAGQGASGSVYLAERTHIPTESNMIELINNDIDEPHVGDKV 591 Query: 385 ALKGIQMNIQESVRKQ-IVQELKINQATQSPHIVLCHQSFYH-NGVIYLVLEYMDRGSLA 558 A+K QM + + RK+ IV E+ + + ++ +IV +++ + +++V+E+M+ GSL Sbjct: 592 AIK--QMVLSKQPRKELIVNEILVMKDSRHKNIVNFLEAYLRTDDDLWVVMEFMEGGSLT 649 Query: 559 DIIKQVKT-------ILEPYLAVLCKQVLEGLLYLHHERHVIHRDIKPSNLLVNHKGEVK 717 DII+ T + EP +A + ++ +GL +LH ++H+IHRDIK N+L++ + VK Sbjct: 650 DIIENSPTNDNSHSPLTEPQIAYIVRETCQGLKFLH-DKHIIHRDIKSDNVLLDTRARVK 708 Query: 718 ITDFGVSAVLASSIGQRDTFVGTYNYMAPERISGSSYDYKSDVWSLGLVILECAIGRFPY 897 ITDFG A L +R T VGT +MAPE + YD K DVWSLG++ +E G PY Sbjct: 709 ITDFGFCARLTDKRSKRATMVGTPYWMAPEVVKQREYDEKIDVWSLGIMTIEMLEGEPPY 768 Query: 898 TPPEGEGWLSFYELLEAIVDQPPPSAPADQFSPEFCSFISSCIQKDPAERKSASELLNHA 1077 + L + P + S E F+S C+ D R S ELL+H Sbjct: 769 LNED-----PLKALYLIATNGTPKLKHPESLSLEIKRFLSVCLCVDVRYRASTEELLHHG 823 Query: 1078 FIKKFED-KDL 1107 F D KDL Sbjct: 824 FFNMACDPKDL 834
>O14299:WIS4_SCHPO MAP kinase kinase kinase wis4 - Schizosaccharomyces pombe (Fission| yeast) Length = 1401 Score = 129 bits (323), Expect = 4e-29 Identities = 87/261 (33%), Positives = 133/261 (50%), Gaps = 16/261 (6%) Frame = +1 Query: 373 GTFYALKGIQMNIQESVRK---QIVQELKINQATQSPHIVLCHQSFYHNGVIYLVLEYMD 543 G A+K I++ + R QI E+ + + P++V + H +Y+ +E+ Sbjct: 1060 GDLLAVKEIKLQDSRTFRSTVDQIHNEMTVLERLNHPNVVTYYGVEVHREKVYIFMEFCQ 1119 Query: 544 RGSLADIIKQVKTILEPYLAVLCKQVLEGLLYLHHERHVIHRDIKPSNLLVNHKGEVKIT 723 GSLAD++ + E L V Q+LEGL Y+H + H++HRDIKP+N+L++H+G +K + Sbjct: 1120 GGSLADLLAHGRIEDENVLKVYVVQLLEGLAYIHSQ-HILHRDIKPANILLDHRGMIKYS 1178 Query: 724 DFG----VSAVLASSIGQRDT------FVGTYNYMAPERISGSSY-DYKS-DVWSLGLVI 867 DFG VS + D GT YMAPE I G+ D+ + D+WSLG VI Sbjct: 1179 DFGSALYVSPPTDPEVRYEDIQPELQHLAGTPMYMAPEIILGTKKGDFGAMDIWSLGCVI 1238 Query: 868 LECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAPA-DQFSPEFCSFISSCIQKDPAE 1044 LE G P++ + E W Y + PS P ++ S FI C ++DP + Sbjct: 1239 LEMMTGSTPWSEMDNE-WAIMYH----VAAMHTPSIPQNEKISSLARDFIEQCFERDPEQ 1293 Query: 1045 RKSASELLNHAFIKKFEDKDL 1107 R A +LL H +I F K + Sbjct: 1294 RPRAVDLLTHPWITDFRKKTI 1314
>Q12469:SKM1_YEAST Serine/threonine-protein kinase SKM1 - Saccharomyces cerevisiae| (Baker's yeast) Length = 655 Score = 129 bits (323), Expect = 4e-29 Identities = 91/317 (28%), Positives = 155/317 (48%), Gaps = 31/317 (9%) Frame = +1 Query: 226 LISEENGDEHQSTKMKVEDVQLSMDD---LEMIQVIGKGSGGVVQLVR------------ 360 L+ +N D+ MK++ V + ++ ++++ G+G+ G V L + Sbjct: 331 LLELKNNDDSNEIIMKMKTVAIDVNPRPYFQLVEKAGQGASGAVYLSKRIKLPQENDPRF 390 Query: 361 -----HKWVGTFYALKGIQMNIQESVRKQIVQE--LKINQATQSPHIVLCHQSFYHNGVI 519 H+ VG A+K Q+ + E +KQ++ L +N + Q + + + Sbjct: 391 LKSHCHRVVGERVAIK--QIRLSEQPKKQLIMNELLVMNDSRQENIVNFLEAYIIDDEEL 448 Query: 520 YLVLEYMDRGSLADIIKQV---------KTILEPYLAVLCKQVLEGLLYLHHERHVIHRD 672 ++++EYM+ G L DI+ V + E +A + K+ +GL +LH+++ +IHRD Sbjct: 449 WVIMEYMEGGCLTDILDAVARSNTGEHSSPLNENQMAYIVKETCQGLKFLHNKK-IIHRD 507 Query: 673 IKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISGSSYDYKSDVWS 852 IK N+L+N +G VKITDFG L +R T VGT +MAPE ++ YD K DVWS Sbjct: 508 IKSDNILLNSQGLVKITDFGFCVELTEKRSKRATMVGTPYWMAPEIVNQKGYDEKVDVWS 567 Query: 853 LGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAPADQFSPEFCSFISSCIQK 1032 LG++++E G PY E L L+ + P + S + F+ +C+Q Sbjct: 568 LGIMLIEMIEGEPPYL---NEDPLKALYLIAN--NGSPKLRHPESVSKQTKQFLDACLQV 622 Query: 1033 DPAERKSASELLNHAFI 1083 + R S +LL F+ Sbjct: 623 NVESRASVRKLLTFEFL 639
>Q9R0A5:NEK3_MOUSE Serine/threonine-protein kinase Nek3 - Mus musculus (Mouse)| Length = 511 Score = 129 bits (323), Expect = 4e-29 Identities = 93/286 (32%), Positives = 151/286 (52%), Gaps = 4/286 (1%) Frame = +1 Query: 295 MDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQM--NIQESVRKQIVQELKINQATQ 468 MD+ +++VIG+GS G LV + +A+K I++ + ++ RK+ V K+ Sbjct: 1 MDNYTVLRVIGQGSFGRALLVLQESSNQTFAMKEIRLLKSDTQTSRKEAVLLAKMKH--- 57 Query: 469 SPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVL--CKQVLEGLLYL 642 P+IV +SF G +Y+V+EY D G L IKQ K L P +L Q+ G+ ++ Sbjct: 58 -PNIVAFKESFEAEGYLYIVMEYCDGGDLMQRIKQQKGNLFPEDTILNWFIQICLGVNHI 116 Query: 643 HHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISGS 822 H +R V+HRDIK N+ + H G+VK+ DFG + +L+S + T+VGT Y+ PE Sbjct: 117 H-KRRVLHRDIKSKNVFLTHNGKVKLGDFGSARLLSSPMAFACTYVGTPYYVPPEIWENL 175 Query: 823 SYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAPADQFSPEF 1002 Y+ KSD+WSLG ++ E + P+ + W + L+ I P PA +S + Sbjct: 176 PYNNKSDIWSLGCILYELCALKHPF---QANSWKN---LILKICQGPIHPLPA-LYSCKL 228 Query: 1003 CSFISSCIQKDPAERKSASELLNHAFIKKFEDKDLDLRILVESLEQ 1140 + ++++P+ R SA+ LL + K L +I+ E EQ Sbjct: 229 QGLVKQMLKRNPSHRPSATTLLCRGSLAPLVPKCLPPQIIREYGEQ 274
>Q91820:STK6_XENLA Serine/threonine-protein kinase 6 - Xenopus laevis (African clawed| frog) Length = 407 Score = 128 bits (322), Expect = 5e-29 Identities = 91/288 (31%), Positives = 143/288 (49%), Gaps = 2/288 (0%) Frame = +1 Query: 232 SEENGDEHQSTKMKVEDVQLSMDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNI 411 S + G K + + Q ++D E+ + +GKG G V L R + ALK + + Sbjct: 116 STDQGKTSAVPKEEGKKKQWCLEDFEIGRPLGKGKFGNVYLARERESKFILALKVLFKSQ 175 Query: 412 QES--VRKQIVQELKINQATQSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTI 585 E V Q+ +E++I + P+I+ + F+ +YL+L+Y G L +++ Sbjct: 176 LEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDASRVYLILDYAPGGELFRELQKCTRF 235 Query: 586 LEPYLAVLCKQVLEGLLYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQ 765 + A+ KQ+ E LLY H ++ VIHRDIKP NLL+ GE+KI DFG S SS + Sbjct: 236 DDQRSAMYIKQLAEALLYCHSKK-VIHRDIKPENLLLGSNGELKIADFGWSVHAPSS--R 292 Query: 766 RDTFVGTYNYMAPERISGSSYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLE 945 R T GT +Y+ PE I G +D D+WSLG++ E +G+ P+ E + Y + Sbjct: 293 RTTLCGTLDYLPPEMIEGRMHDETVDLWSLGVLCYEFLVGKPPF---ETDTHQETYRRIS 349 Query: 946 AIVDQPPPSAPADQFSPEFCSFISSCIQKDPAERKSASELLNHAFIKK 1089 + Q PP S E +S ++ +P R +L H +I K Sbjct: 350 KVEFQYPP-----YVSEEARDLVSKLLKHNPNHRLPLKGVLEHPWIIK 392
>Q8IVH8:M4K3_HUMAN Mitogen-activated protein kinase kinase kinase kinase 3 - Homo| sapiens (Human) Length = 894 Score = 128 bits (322), Expect = 5e-29 Identities = 85/279 (30%), Positives = 146/279 (52%), Gaps = 4/279 (1%) Frame = +1 Query: 298 DDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQIVQELKINQATQSPH 477 +D E+IQ IG G+ G V R+ G A+K I++ E + QE+ + + + P+ Sbjct: 14 EDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAV-VQQEIIMMKDCKHPN 72 Query: 478 IVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLYLHHERH 657 IV S+ +++ +E+ GSL DI + E +A + ++ L+GL YLH + Sbjct: 73 IVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYYLH-SKG 131 Query: 658 VIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERIS---GSSY 828 +HRDIK +N+L+ G VK+ DFGVSA + ++I +R +F+GT +MAPE + Y Sbjct: 132 KMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGY 191 Query: 829 DYKSDVWSLGLVILECAIGRFPYTPPEGE-GWLSFYELLEAIVDQPPPSAPADQFSPEFC 1005 + D+W++G+ +E A PP + + L+ QPP ++S F Sbjct: 192 NQLCDLWAVGITAIELA----ELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSNSFH 247 Query: 1006 SFISSCIQKDPAERKSASELLNHAFIKKFEDKDLDLRIL 1122 F+ + K+P +R +A +LL H F+ + + L + +L Sbjct: 248 HFVKMALTKNPKKRPTAEKLLQHPFVTQHLTRSLAIELL 286
>Q6GPL3:AUKBB_XENLA Serine/threonine-protein kinase 12-B - Xenopus laevis (African clawed| frog) Length = 368 Score = 128 bits (322), Expect = 5e-29 Identities = 93/285 (32%), Positives = 145/285 (50%), Gaps = 7/285 (2%) Frame = +1 Query: 253 HQSTKMKVEDVQLSMDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNI--QESVR 426 H + + + ++DD ++ + +GKG G V L R K ALK + + +E V Sbjct: 83 HNTALAEAPKRKFTIDDFDIGRPLGKGKFGNVYLAREKQNKFIMALKVLFKSQLEKEGVE 142 Query: 427 KQIVQELKINQATQSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAV 606 Q+ +E++I + P+I+ + F+ IYL+LE+ RG L +++ E A Sbjct: 143 HQLRREIEIQSHLRHPNILRMYNYFHDRKRIYLMLEFAPRGELYKELQKHGRFDEQRSAT 202 Query: 607 LCKQVLEGLLYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGT 786 +++ + L Y H ER VIHRDIKP NLL+ +KGE+KI DFG S V A S+ +R T GT Sbjct: 203 FMEELADALQYCH-ERKVIHRDIKPENLLMGYKGELKIADFGWS-VHAPSL-RRRTMCGT 259 Query: 787 YNYMAPERISGSSYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPP 966 +Y+ PE I G ++D K D+W G++ E +G P+ P S E IV+ Sbjct: 260 LDYLPPEMIEGKTHDEKVDLWCAGVLCYEFLVGMPPFDSP------SHSETHRRIVN--- 310 Query: 967 PSAPADQFSPEFCS-----FISSCIQKDPAERKSASELLNHAFIK 1086 D P F S IS ++ PA+R ++ H ++K Sbjct: 311 ----VDLKFPPFLSEGSKDLISKLLRYHPAQRLPLKGVMEHPWVK 351
>P31749:AKT1_HUMAN RAC-alpha serine/threonine-protein kinase - Homo sapiens (Human)| Length = 480 Score = 128 bits (322), Expect = 5e-29 Identities = 89/326 (27%), Positives = 161/326 (49%), Gaps = 14/326 (4%) Frame = +1 Query: 145 ETPVDK--FLTASGTFKDGELRLNQRGLQLISEENGDEHQSTKMKVEDVQ----LSMDDL 306 ETP ++ + TA T DG + + + S D + +M+V + ++M++ Sbjct: 91 ETPEEREEWTTAIQTVADGLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEF 150 Query: 307 EMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNI---QESVRKQIVQELKINQATQSPH 477 E ++++GKG+ G V LV+ K G +YA+K ++ + ++ V + + ++ Q ++ P Sbjct: 151 EYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTEN-RVLQNSRHPF 209 Query: 478 IVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLYLHHERH 657 + SF + + V+EY + G L + + + E +++ L YLH E++ Sbjct: 210 LTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKN 269 Query: 658 VIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISGSSYDYK 837 V++RD+K NL+++ G +KITDFG+ TF GT Y+APE + + Y Sbjct: 270 VVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRA 329 Query: 838 SDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAPADQFSPEFCSFIS 1017 D W LG+V+ E GR P+ + E +EL+ + P + PE S +S Sbjct: 330 VDWWGLGVVMYEMMCGRLPFYNQDHE---KLFELILMEEIRFPRT-----LGPEAKSLLS 381 Query: 1018 SCIQKDPAER-----KSASELLNHAF 1080 ++KDP +R + A E++ H F Sbjct: 382 GLLKKDPKQRLGGGSEDAKEIMQHRF 407
>P08458:SPS1_YEAST Sporulation-specific protein 1 - Saccharomyces cerevisiae (Baker's| yeast) Length = 490 Score = 127 bits (320), Expect = 9e-29 Identities = 94/289 (32%), Positives = 151/289 (52%), Gaps = 10/289 (3%) Frame = +1 Query: 322 IGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQIVQELKINQATQSPHIVLCHQSF 501 IG+G+ G V + A+K + + + + + QE+ +SP I + Sbjct: 24 IGRGNFGDVYKAVDRVTQEIVAIKVVNLEHSDEDIELLAQEIFFLAELKSPLITNYIATM 83 Query: 502 YHNGVIYLVLEYMDRGSLADIIKQ--VKTILEPYLAVLCKQVLEGLLYLHHERHVIHRDI 675 + +++V+EY GS +D++K+ V + E ++ + +V GL YLH +R IHRDI Sbjct: 84 LEDVSMWIVMEYCGGGSCSDLLKRSYVNGLPEEKVSFIIHEVTLGLKYLHEQRK-IHRDI 142 Query: 676 KPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERI--SGSSYDYKSDVW 849 K +N+L+N +G VK+ DFGVS + S++ +RDTFVGT +MAPE + Y+ K+D+W Sbjct: 143 KAANILLNEEGMVKLGDFGVSGHIRSTL-KRDTFVGTPYWMAPEVVCCEVDGYNEKADIW 201 Query: 850 SLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAPADQ--FSPEFCSFISSC 1023 SLG+ E G PP LS Y+ ++ + + P P Q FS F++ C Sbjct: 202 SLGITTYELLKG----LPP-----LSKYDPMKVMTNLPKRKPPKLQGPFSDAAKDFVAGC 252 Query: 1024 IQKDPAERKSASELLNHAFIKKFE----DKDLDLRILVESLEQPMNVPE 1158 + K PA+R SA LL+ F+K D+DL + E+ VP+ Sbjct: 253 LVKTPADRPSAYNLLSFEFVKNITITNLKSDVDLIKQKKVQERYTKVPK 301
>Q20347:MKK4_CAEEL MAP kinase kinase mkk-4 - Caenorhabditis elegans| Length = 363 Score = 127 bits (320), Expect = 9e-29 Identities = 93/293 (31%), Positives = 146/293 (49%), Gaps = 13/293 (4%) Frame = +1 Query: 247 DEHQSTKMKVEDVQLSMDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNI---QE 417 DEH T S +L+ + IG G+ G V +RHK G A+K I+ N +E Sbjct: 55 DEHLYT--------FSSANLQDLGAIGNGNFGTVYKMRHKETGKLIAVKRIRCNNIGHRE 106 Query: 418 SVRKQIVQELKINQATQSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTIL--- 588 +R + + I ++ + P+IV + + + G ++ +E MD S+ + K+V + Sbjct: 107 QIRL-LREHDTIVKSEKGPNIVKFYGAIFSEGDCWICMELMDI-SMDLLYKRVYMVKNSR 164 Query: 589 --EPYLAVLCKQVLEGLLYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIG 762 E + + ++ L YL E +IHRD+KPSN+LV+ G VK+ DFG+ L S Sbjct: 165 LNENVVGHITVCTVDALDYLKKELKIIHRDVKPSNILVDGTGAVKLCDFGICGQLEESFA 224 Query: 763 QRDTFVGTYNYMAPERISGS-SYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYEL 939 + G Y+APERI+ S YD +SDVWSLG+ + E A G+FPY + W S ++ Sbjct: 225 KTHD-AGCQPYLAPERITSSDKYDVRSDVWSLGITLYEIATGKFPY-----QEWNSLFDQ 278 Query: 940 LEAIVDQPPPSAPAD----QFSPEFCSFISSCIQKDPAERKSASELLNHAFIK 1086 + +V PP D +S FI++C+ KD R L + F + Sbjct: 279 IATVVSGDPPILHPDSDDFHYSLPLVKFINTCLTKDRRHRPKYDTLKSFDFYR 331
>Q5RAJ5:STK36_PONPY Serine/threonine-protein kinase 36 - Pongo pygmaeus (Orangutan)| Length = 1315 Score = 127 bits (319), Expect = 1e-28 Identities = 81/266 (30%), Positives = 142/266 (53%), Gaps = 3/266 (1%) Frame = +1 Query: 295 MDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGI-QMNIQESVRKQIVQELKINQATQS 471 M+ ++++IG+GS G V R K+ ALK I ++ E + + +E++I + + Sbjct: 1 MEKYHVLEMIGEGSFGRVYKGRRKYSAQVVALKFIPKLGRSEKELRNLQREIEIMRGLRH 60 Query: 472 PHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLYLHHE 651 P+IV SF + + +V +Y + G L I++ + E + + Q++ L YLH Sbjct: 61 PNIVHMLDSFETDKEVVVVTDYAE-GELLQILEDDGKLPEDQVQAIAAQLVSALYYLHSH 119 Query: 652 RHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISGSSYD 831 R ++HRD+KP N+L+ G +K+ DFG + ++++ + GT YM+PE + YD Sbjct: 120 R-ILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTSIKGTPLYMSPELVEERPYD 178 Query: 832 YKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPP--PSAPADQFSPEFC 1005 + +D+WS+G ++ E A+G P+ S ++L+ I+ P PS SP F Sbjct: 179 HTADLWSVGCILYELAVGTPPFYA------TSIFQLVSLILKDPVRWPST----ISPCFK 228 Query: 1006 SFISSCIQKDPAERKSASELLNHAFI 1083 +F+ + KDP +R S +LL H FI Sbjct: 229 NFLQGLLTKDPRQRLSWPDLLYHPFI 254
>P97477:STK6_MOUSE Serine/threonine-protein kinase 6 - Mus musculus (Mouse)| Length = 395 Score = 127 bits (318), Expect = 1e-28 Identities = 90/295 (30%), Positives = 149/295 (50%), Gaps = 5/295 (1%) Frame = +1 Query: 232 SEENGDEHQSTKMKVEDV---QLSMDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQ 402 S + ++ Q++ K ED Q +++D ++ + +GKG G V L R + ALK + Sbjct: 97 SGNDSEKEQASLQKTEDTKKRQWTLEDFDIGRPLGKGKFGNVYLARERQSKFILALKVLF 156 Query: 403 MNIQE--SVRKQIVQELKINQATQSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQV 576 E +V Q+ +E++I + P+I+ + F+ +YL+LEY G++ ++++ Sbjct: 157 KTQLEKANVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKL 216 Query: 577 KTILEPYLAVLCKQVLEGLLYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASS 756 E A ++ L Y H +R VIHRDIKP NLL+ GE+KI DFG S SS Sbjct: 217 SKFDEQRTATYITELANALSYCHSKR-VIHRDIKPENLLLGSNGELKIADFGWSVHAPSS 275 Query: 757 IGQRDTFVGTYNYMAPERISGSSYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYE 936 +R T GT +Y+ PE I G +D K D+WSLG++ E +G P+ E + Y Sbjct: 276 --RRTTMCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGMPPF---EAHTYQETYR 330 Query: 937 LLEAIVDQPPPSAPADQFSPEFCSFISSCIQKDPAERKSASELLNHAFIKKFEDK 1101 + + P D + IS ++ + ++R + +E+L H +IK K Sbjct: 331 RISRVEFTFP-----DFVTEGARDLISRLLKHNASQRLTLAEVLEHPWIKANSSK 380
>Q9NRP7:STK36_HUMAN Serine/threonine-protein kinase 36 - Homo sapiens (Human)| Length = 1315 Score = 127 bits (318), Expect = 1e-28 Identities = 81/266 (30%), Positives = 142/266 (53%), Gaps = 3/266 (1%) Frame = +1 Query: 295 MDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGI-QMNIQESVRKQIVQELKINQATQS 471 M+ ++++IG+GS G V R K+ ALK I ++ E + + +E++I + + Sbjct: 1 MEKYHVLEMIGEGSFGRVYKGRRKYSAQVVALKFIPKLGRSEKELRNLQREIEIMRGLRH 60 Query: 472 PHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLYLHHE 651 P+IV SF + + +V +Y + G L I++ + E + + Q++ L YLH Sbjct: 61 PNIVHMLDSFETDKEVVVVTDYAE-GELFQILEDDGKLPEDQVQAIAAQLVSALYYLHSH 119 Query: 652 RHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISGSSYD 831 R ++HRD+KP N+L+ G +K+ DFG + ++++ + GT YM+PE + YD Sbjct: 120 R-ILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTSIKGTPLYMSPELVEERPYD 178 Query: 832 YKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPP--PSAPADQFSPEFC 1005 + +D+WS+G ++ E A+G P+ S ++L+ I+ P PS SP F Sbjct: 179 HTADLWSVGCILYELAVGTPPFYA------TSIFQLVSLILKDPVRWPST----ISPCFK 228 Query: 1006 SFISSCIQKDPAERKSASELLNHAFI 1083 +F+ + KDP +R S +LL H FI Sbjct: 229 NFLQGLLTKDPRQRLSWPDLLYHPFI 254
>O75011:NAK1_SCHPO Serine/threonine-protein kinase nak1 - Schizosaccharomyces pombe| (Fission yeast) Length = 652 Score = 127 bits (318), Expect = 1e-28 Identities = 83/264 (31%), Positives = 143/264 (54%), Gaps = 4/264 (1%) Frame = +1 Query: 313 IQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQIVQELKI-NQATQSP--HIV 483 ++++G+GS G V A+K + ++ E I +E+ + ++ QS +I+ Sbjct: 13 LELVGRGSYGAVYRGICNLTKETVAIKILNLDTDEDEVSDIQKEVAVLSELKQSDVENII 72 Query: 484 LCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLYLHHERHVI 663 H S+ ++++++Y GS+ ++ + I EP ++++ ++ L+ L ++HH +I Sbjct: 73 KYHGSYLVGTNLWIIMDYCHGGSVRTLM-EAGPISEPCISLILRETLQALKFIHHAG-II 130 Query: 664 HRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERI-SGSSYDYKS 840 HRDIK +N+LV+ G VK+ DFGV+A L + +R TF+GT +MAPE I G Y+ + Sbjct: 131 HRDIKAANILVSMSGNVKLCDFGVAAELNINRRKRITFIGTPYWMAPEVIRDGQEYNVMA 190 Query: 841 DVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAPADQFSPEFCSFISS 1020 D+WSLG+ E A G P+ + + + I PP + FS FI+S Sbjct: 191 DIWSLGITAYEIATGSPPHAKEDP------FRAVYLIAHTAPPRLNGN-FSALLKEFIAS 243 Query: 1021 CIQKDPAERKSASELLNHAFIKKF 1092 C+Q P R +SELL FIK++ Sbjct: 244 CLQDVPQRRLDSSELLKSKFIKQY 267
>Q99JP0:M4K3_MOUSE Mitogen-activated protein kinase kinase kinase kinase 3 - Mus| musculus (Mouse) Length = 894 Score = 127 bits (318), Expect = 1e-28 Identities = 85/279 (30%), Positives = 146/279 (52%), Gaps = 4/279 (1%) Frame = +1 Query: 298 DDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQIVQELKINQATQSPH 477 +D E+IQ IG G+ G V R+ G A+K I++ E + QE+ + + + P+ Sbjct: 14 EDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAV-VQQEIIMMKDCKHPN 72 Query: 478 IVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLYLHHERH 657 IV S+ +++ +E+ GSL DI + E +A + ++ L+GL YLH + Sbjct: 73 IVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYYLH-SKG 131 Query: 658 VIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERIS---GSSY 828 +HRDIK +N+L+ G VK+ DFGVSA + ++I +R +F+GT +MAPE + Y Sbjct: 132 KMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGY 191 Query: 829 DYKSDVWSLGLVILECAIGRFPYTPPEGE-GWLSFYELLEAIVDQPPPSAPADQFSPEFC 1005 + D+W++G+ +E A PP + + L+ QPP ++S F Sbjct: 192 NQLCDLWAVGITAIELA----ELQPPMFDLHPMRALFLMTKSNFQPPKLKDKLKWSNSFH 247 Query: 1006 SFISSCIQKDPAERKSASELLNHAFIKKFEDKDLDLRIL 1122 F+ + K+P +R +A +LL H F+ + + L + +L Sbjct: 248 HFVKMALTKNPKKRPNAEKLLQHPFVTQPLTRSLAIELL 286
>Q12851:M4K2_HUMAN Mitogen-activated protein kinase kinase kinase kinase 2 - Homo| sapiens (Human) Length = 819 Score = 127 bits (318), Expect = 1e-28 Identities = 87/303 (28%), Positives = 158/303 (52%), Gaps = 7/303 (2%) Frame = +1 Query: 268 MKVEDVQLS--MDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQIVQ 441 M++ DV L D E++Q +G G+ G V R A+K ++++ + + + Q Sbjct: 1 MELRDVSLQDPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDI-SSLQQ 59 Query: 442 ELKINQATQSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQV 621 E+ I + + P++V S+ N +++ +E+ GSL +I + E +A +C++ Sbjct: 60 EITILRECRHPNVVAYIGSYLRNDRLWICMEFCGGGSLQEIYHATGPLEERQIAYVCRER 119 Query: 622 LEGLLYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMA 801 L+GL +LH + IHRDIK +NLL+ +G+VK+ DFGVS L +S+ +R +F+GT +MA Sbjct: 120 LKGLHHLHSQGK-IHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWMA 178 Query: 802 PERIS---GSSYDYKSDVWSLGLVILECAIGRFP--YTPPEGEGWLSFYELLEAIVDQPP 966 PE + Y+ DVW+LG+ +E + P + P + L+ QPP Sbjct: 179 PEVAAVERKGGYNELCDVWALGITAIELGELQPPLFHLHP-----MRALMLMSKSSFQPP 233 Query: 967 PSAPADQFSPEFCSFISSCIQKDPAERKSASELLNHAFIKKFEDKDLDLRILVESLEQPM 1146 +++ F F+ + K+P +R +A +LL H F + + L ++L ++ + + Sbjct: 234 KLRDKTRWTQNFHHFLKLALTKNPKKRPTAEKLLQHPFTTQQLPRALLTQLLDKASDPHL 293 Query: 1147 NVP 1155 P Sbjct: 294 GTP 296
>Q9XTG7:AKT2_CAEEL Serine/threonine-protein kinase akt-2 - Caenorhabditis elegans| Length = 528 Score = 127 bits (318), Expect = 1e-28 Identities = 85/284 (29%), Positives = 144/284 (50%), Gaps = 9/284 (3%) Frame = +1 Query: 232 SEENGDEHQSTKMKVEDVQ-------LSMDDLEMIQVIGKGSGGVVQLVRHKWVGTFYAL 390 S + ++ +ST M +++ + ++MDD + ++V+G+G+ G V L R K YA+ Sbjct: 149 STRSDNDFESTVMNIDEPEEVPRKNTVTMDDFDFLKVLGQGTFGKVILCREKSSDKLYAI 208 Query: 391 KGI--QMNIQESVRKQIVQELKINQATQSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADI 564 K I +M + S + E ++ A P + L SF I V+E+ + G L Sbjct: 209 KIIRKEMVVDRSEVAHTLTENRVLYACVHPFLTLLKYSFQAQYHICFVMEFANGGELFTH 268 Query: 565 IKQVKTILEPYLAVLCKQVLEGLLYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAV 744 +++ KT E +++ L YLHH R++++RD+K NLL++ G +KITDFG+ Sbjct: 269 LQRCKTFSEARTRFYGSEIILALGYLHH-RNIVYRDMKLENLLLDRDGHIKITDFGLCKE 327 Query: 745 LASSIGQRDTFVGTYNYMAPERISGSSYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWL 924 + TF GT Y+APE I YD D W +G+V+ E GR P++ E Sbjct: 328 EIKYGDKTSTFCGTPEYLAPEVIEDIDYDRSVDWWGVGVVMYEMMCGRLPFSAKENG--- 384 Query: 925 SFYELLEAIVDQPPPSAPADQFSPEFCSFISSCIQKDPAERKSA 1056 +EL+ + P ++ SPE + +S +++ PA+R A Sbjct: 385 KLFELITTCDLKFP-----NRLSPEAVTLLSGLLERVPAKRLGA 423
>Q9Z1J2:NEK4_MOUSE Serine/threonine-protein kinase Nek4 - Mus musculus (Mouse)| Length = 792 Score = 126 bits (316), Expect = 3e-28 Identities = 80/262 (30%), Positives = 135/262 (51%), Gaps = 4/262 (1%) Frame = +1 Query: 313 IQVIGKGSGGVVQLVRHKWVGTFYALKGIQM-NIQESVRKQIVQELKINQATQSPHIVLC 489 ++V+G+GS G V LV+H+ G Y +K + + N R+ QE ++ + P+IV Sbjct: 9 MRVVGRGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQLKHPNIVTY 68 Query: 490 HQSFYH-NGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVL--CKQVLEGLLYLHHERHV 660 +S+ +G++Y+V+ + + G L +K+ K L P V+ Q+ L YLH E+H+ Sbjct: 69 KESWEGGDGLLYIVMGFCEGGDLYRKLKEQKGQLLPESQVVEWFVQIAMALQYLH-EKHI 127 Query: 661 IHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISGSSYDYKS 840 +HRD+K N+ + +K+ D G++ VL + T +GT YM+PE S Y+YKS Sbjct: 128 LHRDLKTQNVFLTRTNIIKVGDLGIARVLENHGDMASTLIGTPYYMSPELFSNKPYNYKS 187 Query: 841 DVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAPADQFSPEFCSFISS 1020 DVW+LG + E A + + + L+ I++ P P +S E I + Sbjct: 188 DVWALGCCVYEMATLKHAFNAKD------MNSLVYRIIEGKLPPMP-KVYSTELAELIRT 240 Query: 1021 CIQKDPAERKSASELLNHAFIK 1086 + + P ER S +L +IK Sbjct: 241 MLSRRPEERPSVRSILRQPYIK 262
>Q8BPM2:M4K5_MOUSE Mitogen-activated protein kinase kinase kinase kinase 5 - Mus| musculus (Mouse) Length = 847 Score = 126 bits (316), Expect = 3e-28 Identities = 88/297 (29%), Positives = 152/297 (51%), Gaps = 4/297 (1%) Frame = +1 Query: 301 DLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQIVQELKINQATQSPHI 480 D E++Q +G G+ G V R+ G A+K I++ + I QE+ + + + +I Sbjct: 19 DYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDF-SLIQQEIFMVKECKHCNI 77 Query: 481 VLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLYLHHERHV 660 V S+ +++ +EY GSL DI + E +A +C++ L+GL YLH + Sbjct: 78 VAYFGSYLSREKLWICMEYCGGGSLQDIYHVTGPLSEMQIAYVCRETLQGLAYLH-TKGK 136 Query: 661 IHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERIS---GSSYD 831 +HRDIK +N+L+ G+VK+ DFGV+A + ++I +R +F+GT +MAPE + Y+ Sbjct: 137 MHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAVEKNGGYN 196 Query: 832 YKSDVWSLGLVILECAIGRFPYTPPEGE-GWLSFYELLEAIVDQPPPSAPADQFSPEFCS 1008 D+W++G+ +E PP + + L+ QPP ++S F + Sbjct: 197 QLCDIWAVGITAIELG----ELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSSTFHN 252 Query: 1009 FISSCIQKDPAERKSASELLNHAFIKKFEDKDLDLRILVESLEQPMNVPE*GLPLGE 1179 F+ + K+P +R +A LL H F+ + L + VE L++ N P+ P E Sbjct: 253 FVKIALTKNPKKRPTAERLLTHTFVGQ---PGLSRALAVELLDKVSN-PDNHAPYSE 305
>Q05513:KPCZ_HUMAN Protein kinase C zeta type - Homo sapiens (Human)| Length = 592 Score = 126 bits (316), Expect = 3e-28 Identities = 95/351 (27%), Positives = 166/351 (47%), Gaps = 24/351 (6%) Frame = +1 Query: 115 KELTLSVPAQETPVDKFLTASGTFKDGELRLNQR-GLQLISEENGDEHQSTKMKVEDVQ- 288 K + +P+QE PVD +D +L + G+ IS +H S K ED++ Sbjct: 182 KHMDSVMPSQEPPVDD------KNEDADLPSEETDGIAYISSSR--KHDSIKDDSEDLKP 233 Query: 289 -------------LSMDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNI---QES 420 L + D ++I+VIG+GS V LVR K YA+K ++ + E Sbjct: 234 VIDGMDGIKISQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDED 293 Query: 421 VRKQIVQELKINQATQSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYL 600 + ++ QA+ +P +V H F ++LV+EY++ G L +++ + + E + Sbjct: 294 IDWVQTEKHVFEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHA 353 Query: 601 AVLCKQVLEGLLYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFV 780 ++ L +LH ER +I+RD+K N+L++ G +K+TD+G+ TF Sbjct: 354 RFYAAEICIALNFLH-ERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFC 412 Query: 781 GTYNYMAPERISGSSYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQ 960 GT NY+APE + G Y + D W+LG+++ E GR P+ ++ + L ++ + Sbjct: 413 GTPNYIAPEILRGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILE 472 Query: 961 PPPSAPADQFSPEFCSFISSCIQKDPAERKSA------SELLNHAFIKKFE 1095 P P S + + + KDP ER S++ +HAF + + Sbjct: 473 KPIRIPR-FLSVKASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSID 522
>O70126:AURKB_MOUSE Serine/threonine-protein kinase 12 - Mus musculus (Mouse)| Length = 345 Score = 126 bits (316), Expect = 3e-28 Identities = 87/290 (30%), Positives = 149/290 (51%), Gaps = 2/290 (0%) Frame = +1 Query: 223 QLISEENGDEHQSTKMKVEDVQLSMDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQ 402 Q ++E +++ ++D+ E+ + +GKG G V L R K ALK + Sbjct: 55 QKLAENKSQGSTASQGSQNKQPFTIDNFEIGRPLGKGKFGNVYLAREKKSRFIVALKILF 114 Query: 403 MNI--QESVRKQIVQELKINQATQSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQV 576 + +E V Q+ +E++I + P+I+ + FY IYL+LEY RG L +++ Sbjct: 115 KSQIEKEGVEHQLRREIEIQAHLKHPNILQLYNYFYDQQRIYLILEYAPRGELYKELQKS 174 Query: 577 KTILEPYLAVLCKQVLEGLLYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASS 756 +T E A + +++ + L Y H++ VIHRDIKP NLL+ +GE+KI DFG S V A S Sbjct: 175 RTFDEQRTATIMEELSDALTYC-HKKKVIHRDIKPENLLLGLQGELKIADFGWS-VHAPS 232 Query: 757 IGQRDTFVGTYNYMAPERISGSSYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYE 936 + +R T GT +Y+ PE I G ++ D+W +G++ E +G P+ P Y Sbjct: 233 L-RRKTMCGTLDYLPPEMIEGRMHNEMVDLWCIGVLCYELMVGNPPFESPSHS---ETYR 288 Query: 937 LLEAIVDQPPPSAPADQFSPEFCSFISSCIQKDPAERKSASELLNHAFIK 1086 + + + P S P+ IS ++ +P +R +E+ H +++ Sbjct: 289 RIVKVDLKFPSSVPSGA-----QDLISKLLKHNPWQRLPLAEVAAHPWVR 333
>Q6DE08:AUKBA_XENLA Serine/threonine-protein kinase 12-A - Xenopus laevis (African clawed| frog) Length = 361 Score = 126 bits (316), Expect = 3e-28 Identities = 103/330 (31%), Positives = 159/330 (48%), Gaps = 15/330 (4%) Frame = +1 Query: 142 QETPVDKFLTASGTFKDGELRLNQRGLQLISEENGDEHQSTKMKVEDVQLS--------M 297 +E V F T S +L++ S G ST+M ++ L+ + Sbjct: 31 KEPYVSTFTTPSDNLLAQRTQLSRITPSASSSVPGRVAVSTEMPSQNTALAEMPKRKFTI 90 Query: 298 DDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNI--QESVRKQIVQELKINQATQS 471 DD ++ + +GKG G V L R K ALK + + +E V Q+ +E++I + Sbjct: 91 DDFDIGRPLGKGKFGNVYLAREKQNKFIMALKVLFKSQLEKEGVEHQLRREIEIQSHLRH 150 Query: 472 PHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLYLHHE 651 P+I+ + F+ IYL+LE+ RG L +++ E A +++ + L Y H E Sbjct: 151 PNILRMYNYFHDRKRIYLMLEFAPRGELYKELQKHGRFDEQRSATFMEELADALHYCH-E 209 Query: 652 RHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISGSSYD 831 R VIHRDIKP NLL+ +KGE+KI DFG S V A S+ +R T GT +Y+ PE I G ++D Sbjct: 210 RKVIHRDIKPENLLMGYKGELKIADFGWS-VHAPSL-RRRTMCGTLDYLPPEMIEGKTHD 267 Query: 832 YKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAPADQFSPEFCS- 1008 K D+W G++ E +G P+ P S E IV+ D P F S Sbjct: 268 EKVDLWCAGVLCYEFLVGMPPFDSP------SHTETHRRIVN-------VDLKFPPFLSD 314 Query: 1009 ----FISSCIQKDPAERKSASELLNHAFIK 1086 IS ++ P +R ++ H ++K Sbjct: 315 GSKDLISKLLRYHPPQRLPLKGVMEHPWVK 344
>O08648:M3K4_MOUSE Mitogen-activated protein kinase kinase kinase 4 - Mus musculus| (Mouse) Length = 1597 Score = 125 bits (315), Expect = 3e-28 Identities = 96/335 (28%), Positives = 165/335 (49%), Gaps = 23/335 (6%) Frame = +1 Query: 169 TASGTFKDGELRLNQRGLQLISEENGDEHQSTKM--KVEDVQLSMDDLEMIQV------- 321 T K G + Q+ ++L E E + + +V D S D++ + + Sbjct: 1273 TKDSASKQGPIEAIQKSVRLFEERRYREMRRKNIIGQVCDTPKSYDNVMHVGLRKVTFKW 1332 Query: 322 -----IGKGSGGVVQLVRHKWVGTFYALKGI--QMNIQESVRKQIVQELKINQATQSPHI 480 IG+G G V G A+K I Q N +++ K+ ELKI + + P++ Sbjct: 1333 QRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTI-KETADELKIFEGIKHPNL 1391 Query: 481 VLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLYLHHERHV 660 V H +Y+ +EY D G+L ++ + + E + + KQ+ + LH E + Sbjct: 1392 VRYFGVELHREEMYIFMEYCDEGTLEEVSRL--GLQEHVIRLYTKQITVAINVLH-EHGI 1448 Query: 661 IHRDIKPSNLLVNHKGEVKITDFGVSAVLASSI----GQRDTFVGTYNYMAPE---RISG 819 +HRDIK +N+ + G +K+ DFG S L ++ G+ ++ +GT YMAPE R G Sbjct: 1449 VHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVITRAKG 1508 Query: 820 SSYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAPADQFSPE 999 + +D+WSLG V++E G+ P+ E +F + + + PP ++ SPE Sbjct: 1509 EGHGRAADIWSLGCVVIEMVTGKRPWHEYEH----NFQIMYKVGMGHKPPIP--ERLSPE 1562 Query: 1000 FCSFISSCIQKDPAERKSASELLNHAFIKKFEDKD 1104 +F+S C++ DP R +AS+LL+HAF+K D++ Sbjct: 1563 GKAFLSHCLESDPKIRWTASQLLDHAFVKVCTDEE 1597
>O22042:M3K3_ARATH Mitogen-activated protein kinase kinase kinase 3 - Arabidopsis| thaliana (Mouse-ear cress) Length = 651 Score = 125 bits (315), Expect = 3e-28 Identities = 77/265 (29%), Positives = 147/265 (55%), Gaps = 9/265 (3%) Frame = +1 Query: 316 QVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVR-------KQIVQELKINQATQSP 474 ++IG G+ G V + + G A+K + + + + +++ +E+++ + P Sbjct: 72 ELIGCGAFGRVYMGMNLDSGELLAIKQVLIAPSSASKEKTQGHIRELEEEVQLLKNLSHP 131 Query: 475 HIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLYLHHER 654 +IV + + + +++E++ GS++ ++++ + EP + + KQ+L GL YLH+ Sbjct: 132 NIVRYLGTVRESDSLNILMEFVPGGSISSLLEKFGSFPEPVIIMYTKQLLLGLEYLHNNG 191 Query: 655 HVIHRDIKPSNLLVNHKGEVKITDFGVS--AVLASSIGQRDTFVGTYNYMAPERISGSSY 828 ++HRDIK +N+LV++KG +++ DFG S V +++ + GT +MAPE I + + Sbjct: 192 -IMHRDIKGANILVDNKGCIRLADFGASKKVVELATVNGAKSMKGTPYWMAPEVILQTGH 250 Query: 829 DYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAPADQFSPEFCS 1008 + +D+WS+G ++E A G+ PP E + F +L + P P D SPE Sbjct: 251 SFSADIWSVGCTVIEMATGK----PPWSEQYQQFAAVLHIGRTKAHPPIPED-LSPEAKD 305 Query: 1009 FISSCIQKDPAERKSASELLNHAFI 1083 F+ C+ K+P+ R SA+ELL H F+ Sbjct: 306 FLMKCLHKEPSLRLSATELLQHPFV 330
>Q9Y4K4:M4K5_HUMAN Mitogen-activated protein kinase kinase kinase kinase 5 - Homo| sapiens (Human) Length = 846 Score = 125 bits (314), Expect = 4e-28 Identities = 85/287 (29%), Positives = 148/287 (51%), Gaps = 4/287 (1%) Frame = +1 Query: 301 DLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQIVQELKINQATQSPHI 480 D E++Q +G G+ G V R+ G A+K I++ + I QE+ + + + +I Sbjct: 19 DYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDF-SLIQQEIFMVKECKHCNI 77 Query: 481 VLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLYLHHERHV 660 V S+ +++ +EY GSL DI + E +A +C++ L+GL YLH + Sbjct: 78 VAYFGSYLSREKLWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLH-TKGK 136 Query: 661 IHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERIS---GSSYD 831 +HRDIK +N+L+ G+VK+ DFGV+A + ++I +R +F+GT +MAPE + Y+ Sbjct: 137 MHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAVEKNGGYN 196 Query: 832 YKSDVWSLGLVILECAIGRFPYTPPEGE-GWLSFYELLEAIVDQPPPSAPADQFSPEFCS 1008 D+W++G+ +E PP + + L+ QPP ++S F + Sbjct: 197 QLCDIWAVGITAIELG----ELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSSTFHN 252 Query: 1009 FISSCIQKDPAERKSASELLNHAFIKKFEDKDLDLRILVESLEQPMN 1149 F+ + K+P +R +A LL H F+ + L + VE L++ N Sbjct: 253 FVKIALTKNPKKRPTAERLLTHTFVAQ---PGLSRALAVELLDKVNN 296
>P22612:KAPCG_HUMAN cAMP-dependent protein kinase, gamma-catalytic subunit - Homo| sapiens (Human) Length = 351 Score = 125 bits (314), Expect = 4e-28 Identities = 76/206 (36%), Positives = 116/206 (56%), Gaps = 4/206 (1%) Frame = +1 Query: 292 SMDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVR----KQIVQELKINQ 459 S D E ++ +G GS G V LVRH+ G YA+K +N Q+ V+ + I+ E +I Q Sbjct: 40 SSDQFERLRTLGMGSFGRVMLVRHQETGGHYAMK--ILNKQKVVKMKQVEHILNEKRILQ 97 Query: 460 ATQSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLY 639 A P +V SF N +YLV+EY+ G + +++V EP+ QV+ + Y Sbjct: 98 AIDFPFLVKLQFSFKDNSYLYLVMEYVPGGEMFSRLQRVGRFSEPHACFYAAQVVLAVQY 157 Query: 640 LHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISG 819 L H +IHRD+KP NLL++ +G +++TDFG + + G+ T GT Y+APE I Sbjct: 158 L-HSLDLIHRDLKPENLLIDQQGYLQVTDFGFAKRVK---GRTWTLCGTPEYLAPEIILS 213 Query: 820 SSYDYKSDVWSLGLVILECAIGRFPY 897 Y+ D W+LG++I E A+G P+ Sbjct: 214 KGYNKAVDWWALGVLIYEMAVGFPPF 239
>Q9M077:AUR1_ARATH Serine/threonine-protein kinase Aurora-1 - Arabidopsis thaliana| (Mouse-ear cress) Length = 294 Score = 125 bits (314), Expect = 4e-28 Identities = 84/271 (30%), Positives = 137/271 (50%), Gaps = 2/271 (0%) Frame = +1 Query: 292 SMDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGI-QMNIQES-VRKQIVQELKINQAT 465 ++ D ++ + +G+G G V L R K ALK + + +Q+S V Q+ +E++I Sbjct: 27 TLSDFDIGKPLGRGKFGHVYLAREKRSNHVVALKVLFKSQLQQSQVEHQLRREVEIQSHL 86 Query: 466 QSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLYLH 645 + P+I+ + FY +YL+LEY RG L +++ K E A + L+Y H Sbjct: 87 RHPNILRLYGYFYDQKRVYLILEYAARGELYKDLQKCKYFSERRAATYVASLARALIYCH 146 Query: 646 HERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISGSS 825 +HVIHRDIKP NLL+ +GE+KI DFG S + +R T GT +Y+ PE + Sbjct: 147 G-KHVIHRDIKPENLLIGAQGELKIADFGWS---VHTFNRRRTMCGTLDYLPPEMVESVE 202 Query: 826 YDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAPADQFSPEFC 1005 +D D+WSLG++ E G P+ E ++ +++ + PP S Sbjct: 203 HDASVDIWSLGILCYEFLYGVPPFEAMEHSD--TYRRIVQVDLKFPPKPI----ISASAK 256 Query: 1006 SFISSCIQKDPAERKSASELLNHAFIKKFED 1098 IS + K+ ++R +LL H +I + D Sbjct: 257 DLISQMLVKESSQRLPLHKLLEHPWIVQNAD 287
>P31751:AKT2_HUMAN RAC-beta serine/threonine-protein kinase - Homo sapiens (Human)| Length = 481 Score = 125 bits (314), Expect = 4e-28 Identities = 85/299 (28%), Positives = 145/299 (48%), Gaps = 7/299 (2%) Frame = +1 Query: 232 SEENGDEHQSTKMKVEDVQLSMDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMN- 408 S+ + E + +++M+D + ++++GKG+ G V LVR K G +YA+K ++ Sbjct: 128 SDSSTTEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEV 187 Query: 409 -IQESVRKQIVQELKINQATQSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTI 585 I + V E ++ Q T+ P + +F + + V+EY + G L + + + Sbjct: 188 IIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVF 247 Query: 586 LEPYLAVLCKQVLEGLLYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQ 765 E +++ L YLH R V++RDIK NL+++ G +KITDFG+ S Sbjct: 248 TEERARFYGAEIVSALEYLH-SRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGAT 306 Query: 766 RDTFVGTYNYMAPERISGSSYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLE 945 TF GT Y+APE + + Y D W LG+V+ E GR P+ + E +EL+ Sbjct: 307 MKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHE---RLFELIL 363 Query: 946 AIVDQPPPSAPADQFSPEFCSFISSCIQKDPAER-----KSASELLNHAFIKKFEDKDL 1107 + P + SPE S ++ ++KDP +R A E++ H F +D+ Sbjct: 364 MEEIRFPRT-----LSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDV 417
>Q7ZX15:AKT2A_XENLA RAC-beta serine/threonine-protein kinase-A - Xenopus laevis (African| clawed frog) Length = 486 Score = 125 bits (314), Expect = 4e-28 Identities = 87/304 (28%), Positives = 149/304 (49%), Gaps = 7/304 (2%) Frame = +1 Query: 232 SEENGDEHQSTKMKVEDVQLSMDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMN- 408 S+ + E M +++M+D + ++++GKG+ G V LVR K G +YA+K ++ Sbjct: 133 SDVSSAEQMDVAMSKGHPKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEV 192 Query: 409 -IQESVRKQIVQELKINQATQSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTI 585 I + + E ++ Q T+ P + +F + + V+EY + G L + + + Sbjct: 193 IIAKDEVAHTLTESRVLQNTKHPFLTALKYAFQTSDRLCFVMEYANGGELFFHLSRERVF 252 Query: 586 LEPYLAVLCKQVLEGLLYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQ 765 E +++ L YLH R+V++RDIK NL+++ G VKITDFG+ + Sbjct: 253 TEDRARFYGAEIVSALEYLH-SRNVVYRDIKLENLMLDKDGHVKITDFGLCKEGITDGAT 311 Query: 766 RDTFVGTYNYMAPERISGSSYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLE 945 TF GT Y+APE + + Y D W LG+V+ E GR P+ + E +EL+ Sbjct: 312 MRTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHE---RLFELIL 368 Query: 946 AIVDQPPPSAPADQFSPEFCSFISSCIQKDPAER-----KSASELLNHAFIKKFEDKDLD 1110 + P + SPE S ++ ++KDP +R A E+++H F +D+ Sbjct: 369 MEEIRFPRT-----LSPEAKSLLAGLLKKDPKQRLGGGPNDAQEVMSHRFFVSINWQDVT 423 Query: 1111 LRIL 1122 R L Sbjct: 424 ERKL 427
>O88664:TAOK1_RAT Serine/threonine-protein kinase TAO1 - Rattus norvegicus (Rat)| Length = 1001 Score = 125 bits (313), Expect = 6e-28 Identities = 88/263 (33%), Positives = 138/263 (52%), Gaps = 6/263 (2%) Frame = +1 Query: 313 IQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRK--QIVQELKINQATQSPHIVL 486 ++ IG GS G V R A+K + + ++S K I++E+K Q + P+ + Sbjct: 31 LREIGHGSFGAVYFARDVRTNEVVAIKKMSYSGKQSTEKWQDIIKEVKFLQRIKHPNSIE 90 Query: 487 CHQSFYHNGVIYLVLEYMDRGSLADIIK-QVKTILEPYLAVLCKQVLEGLLYLHHERHVI 663 + +LV+EY GS +D+++ K + E +A + L+GL YLH +I Sbjct: 91 YKGCYLREHTAWLVMEYC-LGSASDLLEVHKKPLQEVEIAAITHGALQGLAYLHSHT-MI 148 Query: 664 HRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISG---SSYDY 834 HRDIK N+L+ G+VK+ DFG SA +AS ++FVGT +MAPE I YD Sbjct: 149 HRDIKAGNILLTEPGQVKLADFG-SASMASPA---NSFVGTPYWMAPEVILAMDEGQYDG 204 Query: 835 KSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAPADQFSPEFCSFI 1014 K DVWSLG+ +E A + P ++ L I P+ ++++S F +F+ Sbjct: 205 KVDVWSLGITCIELAERKPPLFN------MNAMSALYHIAQNESPTLQSNEWSDYFRNFV 258 Query: 1015 SSCIQKDPAERKSASELLNHAFI 1083 SC+QK P +R ++ ELL H F+ Sbjct: 259 DSCLQKIPQDRPTSEELLKHMFV 281
>Q5F2E8:TAOK1_MOUSE Serine/threonine-protein kinase TAO1 - Mus musculus (Mouse)| Length = 1001 Score = 125 bits (313), Expect = 6e-28 Identities = 88/263 (33%), Positives = 138/263 (52%), Gaps = 6/263 (2%) Frame = +1 Query: 313 IQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRK--QIVQELKINQATQSPHIVL 486 ++ IG GS G V R A+K + + ++S K I++E+K Q + P+ + Sbjct: 31 LREIGHGSFGAVYFARDVRTNEVVAIKKMSYSGKQSTEKWQDIIKEVKFLQRIKHPNSIE 90 Query: 487 CHQSFYHNGVIYLVLEYMDRGSLADIIK-QVKTILEPYLAVLCKQVLEGLLYLHHERHVI 663 + +LV+EY GS +D+++ K + E +A + L+GL YLH +I Sbjct: 91 YKGCYLREHTAWLVMEYC-LGSASDLLEVHKKPLQEVEIAAITHGALQGLAYLHSHT-MI 148 Query: 664 HRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISG---SSYDY 834 HRDIK N+L+ G+VK+ DFG SA +AS ++FVGT +MAPE I YD Sbjct: 149 HRDIKAGNILLTEPGQVKLADFG-SASMASPA---NSFVGTPYWMAPEVILAMDEGQYDG 204 Query: 835 KSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAPADQFSPEFCSFI 1014 K DVWSLG+ +E A + P ++ L I P+ ++++S F +F+ Sbjct: 205 KVDVWSLGITCIELAERKPPLFN------MNAMSALYHIAQNESPTLQSNEWSDYFRNFV 258 Query: 1015 SSCIQKDPAERKSASELLNHAFI 1083 SC+QK P +R ++ ELL H F+ Sbjct: 259 DSCLQKIPQDRPTSEELLKHMFV 281
>Q7L7X3:TAOK1_HUMAN Serine/threonine-protein kinase TAO1 - Homo sapiens (Human)| Length = 1001 Score = 125 bits (313), Expect = 6e-28 Identities = 88/263 (33%), Positives = 138/263 (52%), Gaps = 6/263 (2%) Frame = +1 Query: 313 IQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRK--QIVQELKINQATQSPHIVL 486 ++ IG GS G V R A+K + + ++S K I++E+K Q + P+ + Sbjct: 31 LREIGHGSFGAVYFARDVRTNEVVAIKKMSYSGKQSTEKWQDIIKEVKFLQRIKHPNSIE 90 Query: 487 CHQSFYHNGVIYLVLEYMDRGSLADIIK-QVKTILEPYLAVLCKQVLEGLLYLHHERHVI 663 + +LV+EY GS +D+++ K + E +A + L+GL YLH +I Sbjct: 91 YKGCYLREHTAWLVMEYC-LGSASDLLEVHKKPLQEVEIAAITHGALQGLAYLHSHT-MI 148 Query: 664 HRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISG---SSYDY 834 HRDIK N+L+ G+VK+ DFG SA +AS ++FVGT +MAPE I YD Sbjct: 149 HRDIKAGNILLTEPGQVKLADFG-SASMASPA---NSFVGTPYWMAPEVILAMDEGQYDG 204 Query: 835 KSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAPADQFSPEFCSFI 1014 K DVWSLG+ +E A + P ++ L I P+ ++++S F +F+ Sbjct: 205 KVDVWSLGITCIELAERKPPLFN------MNAMSALYHIAQNESPTLQSNEWSDYFRNFV 258 Query: 1015 SSCIQKDPAERKSASELLNHAFI 1083 SC+QK P +R ++ ELL H F+ Sbjct: 259 DSCLQKIPQDRPTSEELLKHIFV 281
>Q683C9:AUR2_ARATH Serine/threonine-protein kinase Aurora-2 - Arabidopsis thaliana| (Mouse-ear cress) Length = 282 Score = 125 bits (313), Expect = 6e-28 Identities = 86/268 (32%), Positives = 132/268 (49%), Gaps = 2/268 (0%) Frame = +1 Query: 301 DLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGI-QMNIQES-VRKQIVQELKINQATQSP 474 D ++ + +G+G G V L R K ALK + + +Q+S V Q+ +E++I + P Sbjct: 18 DFDIGKPLGRGKFGHVYLAREKRSDHIVALKVLFKAQLQQSQVEHQLRREVEIQSHLRHP 77 Query: 475 HIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLYLHHER 654 +I+ + FY +YL+LEY RG L +++ K E A + L+Y H + Sbjct: 78 NILRLYGYFYDQKRVYLILEYAVRGELYKELQKCKYFSERRAATYVASLARALIYCHG-K 136 Query: 655 HVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISGSSYDY 834 HVIHRDIKP NLL+ +GE+KI DFG S + +R T GT +Y+ PE + +D Sbjct: 137 HVIHRDIKPENLLIGAQGELKIADFGWS---VHTFNRRRTMCGTLDYLPPEMVESVEHDA 193 Query: 835 KSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAPADQFSPEFCSFI 1014 D+WSLG++ E G P+ E E + IV P S I Sbjct: 194 SVDIWSLGILCYEFLYGVPPFEAREHS------ETYKRIVQVDLKFPPKPIVSSSAKDLI 247 Query: 1015 SSCIQKDPAERKSASELLNHAFIKKFED 1098 S + K+ +R + +LL H +I + D Sbjct: 248 SQMLVKESTQRLALHKLLEHPWIVQNAD 275
>Q6IP76:AKT2B_XENLA RAC-beta serine/threonine-protein kinase-B - Xenopus laevis (African| clawed frog) Length = 485 Score = 125 bits (313), Expect = 6e-28 Identities = 87/304 (28%), Positives = 149/304 (49%), Gaps = 7/304 (2%) Frame = +1 Query: 232 SEENGDEHQSTKMKVEDVQLSMDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMN- 408 S+ + E M +++M+D + ++++GKG+ G V LVR K G +YA+K ++ Sbjct: 132 SDVSSAEQMDVAMSKGRPKVTMNDFDYLKLLGKGTFGKVILVREKATGLYYAMKILRKEV 191 Query: 409 -IQESVRKQIVQELKINQATQSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTI 585 I + + E ++ Q T+ P + +F + + V+EY + G L + + + Sbjct: 192 IIAKDEVAHTLTESRVLQNTKHPFLTGLKYAFQTSDRLCFVMEYANGGELFFHLSRERVF 251 Query: 586 LEPYLAVLCKQVLEGLLYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQ 765 E +++ L YLH R+V++RDIK NL+++ G VKITDFG+ + Sbjct: 252 TEDRARFYGAEIVSALEYLH-SRNVVYRDIKLENLMLDKDGHVKITDFGLCKEGITDGAT 310 Query: 766 RDTFVGTYNYMAPERISGSSYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLE 945 TF GT Y+APE + + Y D W LG+V+ E GR P+ + E +EL+ Sbjct: 311 MRTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHE---RLFELIL 367 Query: 946 AIVDQPPPSAPADQFSPEFCSFISSCIQKDPAER-----KSASELLNHAFIKKFEDKDLD 1110 + P + SPE S ++ ++KDP +R A E+++H F +D+ Sbjct: 368 MEETRFPRT-----LSPEAKSLLAGLLKKDPKQRLGGGPDDAQEVMSHGFFASINWQDVT 422 Query: 1111 LRIL 1122 R L Sbjct: 423 ERKL 426
>Q09170:CDS1_SCHPO Serine/threonine-protein kinase cds1 - Schizosaccharomyces pombe| (Fission yeast) Length = 460 Score = 124 bits (312), Expect = 7e-28 Identities = 84/270 (31%), Positives = 140/270 (51%), Gaps = 14/270 (5%) Frame = +1 Query: 307 EMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQM------NIQESVRKQIVQELKINQATQ 468 E+I+ +G G+ VV+L G +YA+K I + ++ + +E+ I ++ Sbjct: 168 EIIRTLGSGTFAVVKLAVEVNSGKWYAIKIINKRKILLTSSEKRATEMFQREIDILKSLH 227 Query: 469 SPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLYLHH 648 P +V CH+ F ++ +++V+EY++ G L D + +I E L KQ+LE LL+LH Sbjct: 228 HPGVVQCHEIFENDDELFIVMEYVEGGDLMDFLIANGSIDEQDCKPLLKQLLETLLHLH- 286 Query: 649 ERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISGSS- 825 ++ V HRDIKP N+L+ + +KI+DFG++ V+ + +TF GT Y+APE + + Sbjct: 287 KQGVTHRDIKPENILITNDFHLKISDFGLAKVIHGTGTFLETFCGTMGYLAPEVLKSKNV 346 Query: 826 -----YDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAP--AD 984 YD K D+WSLG V+ P+ S + +E I P P + Sbjct: 347 NLDGGYDDKVDIWSLGCVLYVMLTASIPFASS------SQAKCIELISKGAYPIEPLLEN 400 Query: 985 QFSPEFCSFISSCIQKDPAERKSASELLNH 1074 + S E I+ ++ +P +R S SE L H Sbjct: 401 EISEEGIDLINRMLEINPEKRISESEALQH 430
>Q61161:M4K2_MOUSE Mitogen-activated protein kinase kinase kinase kinase 2 - Mus| musculus (Mouse) Length = 821 Score = 124 bits (311), Expect = 1e-27 Identities = 83/276 (30%), Positives = 144/276 (52%), Gaps = 7/276 (2%) Frame = +1 Query: 274 VEDVQLS--MDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQIVQEL 447 + DV L D E++Q +G G+ G V R A+K ++++ + + + QE+ Sbjct: 4 LRDVSLQDPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDI-SSLQQEI 62 Query: 448 KINQATQSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLE 627 I + + P++V S+ N +++ +E+ GSL +I + E +A +C++ L+ Sbjct: 63 TILRECRHPNVVAYIGSYLRNDRLWICMEFCGGGSLQEIYHATGPLEERQIAYVCREALK 122 Query: 628 GLLYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPE 807 GL +LH + IHRDIK +NLL+ +G+VK+ DFGVS L +S+ +R +F+GT +MAPE Sbjct: 123 GLHHLHSQGK-IHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWMAPE 181 Query: 808 RIS---GSSYDYKSDVWSLGLVILECAIGRFP--YTPPEGEGWLSFYELLEAIVDQPPPS 972 + Y+ DVW+LG+ +E + P + P + L+ QPP Sbjct: 182 VAAVERKGGYNELCDVWALGITAIELGELQPPLFHLHP-----MRALMLMSKSSFQPPKL 236 Query: 973 APADQFSPEFCSFISSCIQKDPAERKSASELLNHAF 1080 +++ F F+ + K+P +R +A LL H F Sbjct: 237 RDKTRWTQNFHHFLKLALTKNPKKRPTAERLLQHPF 272
>Q9I9E0:TAOK3_CHICK Serine/threonine-protein kinase TAO3 - Gallus gallus (Chicken)| Length = 898 Score = 124 bits (310), Expect = 1e-27 Identities = 90/291 (30%), Positives = 151/291 (51%), Gaps = 10/291 (3%) Frame = +1 Query: 298 DDLEMIQV----IGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRK--QIVQELKINQ 459 DD E I V IG GS G V + A+K + + +++ K I++E+K Q Sbjct: 18 DDPEEIFVGLHEIGHGSFGAVYFATNSHTNEVVAVKKMSYSGKQTNEKWQDIIKEVKFLQ 77 Query: 460 ATQSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIK-QVKTILEPYLAVLCKQVLEGLL 636 + P+ + + +LV+EY GS +D+++ K + E +A + L+GL Sbjct: 78 QLKHPNTIEYKGCYLKEHTAWLVMEYC-LGSASDMLEVHKKPLQEVEIAAITHGALQGLA 136 Query: 637 YLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERIS 816 YLH IHRDIK N+L+ G+VK+ DFG +++++ + ++FVGT +MAPE I Sbjct: 137 YLHSHCK-IHRDIKAGNILLTEPGQVKLADFGSASIVSPA----NSFVGTPYWMAPEVIL 191 Query: 817 G---SSYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAPADQ 987 YD K DVWSLG+ +E A + P ++ L I P+ +++ Sbjct: 192 AMDEGQYDGKVDVWSLGITCIELAERKPPLFN------MNAMSALYHIAQNDSPTLQSNE 245 Query: 988 FSPEFCSFISSCIQKDPAERKSASELLNHAFIKKFEDKDLDLRILVESLEQ 1140 +S F F+ C+QK P ER S+++LL H F++ +D R+L++ +++ Sbjct: 246 WSDSFRGFVDYCLQKIPQERPSSADLLRHDFVR----RDRPPRVLIDLIQR 292
>Q924I2:M4K3_RAT Mitogen-activated protein kinase kinase kinase kinase 3 - Rattus| norvegicus (Rat) Length = 873 Score = 124 bits (310), Expect = 1e-27 Identities = 84/279 (30%), Positives = 145/279 (51%), Gaps = 4/279 (1%) Frame = +1 Query: 298 DDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQIVQELKINQATQSPH 477 +D E+IQ IG G+ G V R+ G A+K I++ E + QE+ + + + + Sbjct: 14 EDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAV-VQQEIIMMKDCKHAN 72 Query: 478 IVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLYLHHERH 657 IV S+ +++ +E+ GSL DI + E +A + ++ L+GL YLH + Sbjct: 73 IVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYYLH-SKG 131 Query: 658 VIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERIS---GSSY 828 +HRDIK +N+L+ G VK+ DFGVSA + ++I +R +F+GT +MAPE + Y Sbjct: 132 KMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGY 191 Query: 829 DYKSDVWSLGLVILECAIGRFPYTPPEGE-GWLSFYELLEAIVDQPPPSAPADQFSPEFC 1005 + D+W++G+ +E A PP + + L+ QPP ++S F Sbjct: 192 NQLCDLWAVGITAIELA----ELQPPMFDLHPMRALFLMTKSNFQPPKLKDKLKWSNSFH 247 Query: 1006 SFISSCIQKDPAERKSASELLNHAFIKKFEDKDLDLRIL 1122 F+ + K+P +R +A +LL H F+ + + L + +L Sbjct: 248 HFVKMALTKNPKKRPTAEKLLQHPFVTQPLTRSLAIELL 286
>O19111:KPCZ_RABIT Protein kinase C zeta type - Oryctolagus cuniculus (Rabbit)| Length = 591 Score = 124 bits (310), Expect = 1e-27 Identities = 93/339 (27%), Positives = 168/339 (49%), Gaps = 18/339 (5%) Frame = +1 Query: 133 VPAQETPV-----DKFLTASGTFKDGELRLNQRGLQLISEENGDEHQSTKMKVEDVQLS- 294 +P+QE PV D L + T DG ++ R Q +E+ ++ + V+ +++S Sbjct: 188 MPSQEPPVADKSDDADLPSQET--DGIAFISTRK-QDSGQEDAEDLKPVIDGVDGIKISQ 244 Query: 295 ---MDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNI---QESVRKQIVQELKIN 456 + D ++I+VIG+GS V LVR K G YA+K ++ + E + ++ Sbjct: 245 GLGLQDFDLIRVIGRGSYAKVLLVRLKKNGQVYAMKVVKKELVHDDEDIDWVQTEKHVFE 304 Query: 457 QATQSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLL 636 QA+ +P +V H F ++LV+EY++ G L +++ + + E + ++ L Sbjct: 305 QASGNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALN 364 Query: 637 YLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERIS 816 +LH ER +I+RD+K N+L++ G +K+TD+G+ TF GT NY+APE + Sbjct: 365 FLH-ERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILR 423 Query: 817 GSSYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAPADQFSP 996 G Y + D W+LG+++ E GR P+ ++ + L ++ + P P S Sbjct: 424 GEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPR-FLSV 482 Query: 997 EFCSFISSCIQKDPAERKSA------SELLNHAFIKKFE 1095 + + + KDP ER S++ +HAF + + Sbjct: 483 KASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSID 521
>O55099:AURKB_RAT Serine/threonine-protein kinase 12 - Rattus norvegicus (Rat)| Length = 343 Score = 124 bits (310), Expect = 1e-27 Identities = 84/267 (31%), Positives = 141/267 (52%), Gaps = 2/267 (0%) Frame = +1 Query: 292 SMDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNI--QESVRKQIVQELKINQAT 465 ++D+ E+ + +GKG G V L R K ALK + + +E V Q+ +E++I Sbjct: 76 TIDNFEIGRPLGKGKFGNVYLAREKKSRFIVALKILFKSQIEKEGVEHQLRREIEIQAHL 135 Query: 466 QSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLYLH 645 + P+I+ + FY IYL+LEY RG L +++ T E A + +++ + L+Y Sbjct: 136 KHPNILQLYNYFYDQQRIYLILEYAPRGELYKELQKSGTFDEQRTATIMEELSDALMYC- 194 Query: 646 HERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISGSS 825 H++ VIHRDIKP NLL+ +GE+KI DFG S V A S+ +R T GT +Y+ PE I G Sbjct: 195 HKKKVIHRDIKPENLLLGLQGELKIADFGWS-VHAPSL-RRKTMCGTLDYLPPEMIEGRM 252 Query: 826 YDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAPADQFSPEFC 1005 ++ D+W +G++ E +G P+ P Y + + + P S P Sbjct: 253 HNEMVDLWCIGVLCYELMVGNPPFESPSHS---ETYRRIVKVDLKFPSSMPLGA-----K 304 Query: 1006 SFISSCIQKDPAERKSASELLNHAFIK 1086 IS ++ +P++R ++ H +++ Sbjct: 305 DLISKLLKHNPSQRLPLEQVSAHPWVR 331
>P46549:SULU_CAEEL Serine/threonine-protein kinase SULU - Caenorhabditis elegans| Length = 982 Score = 123 bits (309), Expect = 2e-27 Identities = 93/275 (33%), Positives = 136/275 (49%), Gaps = 11/275 (4%) Frame = +1 Query: 313 IQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRK--QIVQELKINQATQSPHIVL 486 ++ IG GS G V K A+K + + +++V K I++E+ PHIV Sbjct: 33 LREIGHGSFGAVYFAYDKKNEQTVAIKKMNFSGKQAVEKWNDILKEVSFLNTVVHPHIVD 92 Query: 487 CHQSFYHNGVIYLVLEYMDRGSLADIIKQV-KTILEPYLAVLCKQVLEGLLYLHHERHVI 663 F + +LV+EY GS ADI+ + K + E +A +C Q L+ L YLH + I Sbjct: 93 YKACFLKDTTCWLVMEYCI-GSAADIVDVLRKGMREVEIAAICSQTLDALRYLHSLKR-I 150 Query: 664 HRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISGSS---YDY 834 HRDIK N+L++ VK+ DFG AS + TF+GT +MAPE I Y Sbjct: 151 HRDIKAGNILLSDHAIVKLADFGS----ASLVDPAQTFIGTPFFMAPEVILAMDEGHYTD 206 Query: 835 KSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAPAD-----QFSPE 999 ++D+WSLG+ +E A R P L Y + + + PP +P D ++S E Sbjct: 207 RADIWSLGITCIELAERRPPLFSMNAMSAL--YHIAQ---NDPPTLSPIDTSEQPEWSLE 261 Query: 1000 FCSFISSCIQKDPAERKSASELLNHAFIKKFEDKD 1104 F FI C++K ER SA E H FI++ D Sbjct: 262 FVQFIDKCLRKPAEERMSAEECFRHPFIQRSRPSD 296
>P51954:NEK1_MOUSE Serine/threonine-protein kinase Nek1 - Mus musculus (Mouse)| Length = 1203 Score = 123 bits (309), Expect = 2e-27 Identities = 83/280 (29%), Positives = 143/280 (51%), Gaps = 2/280 (0%) Frame = +1 Query: 295 MDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMN-IQESVRKQIVQELKINQATQS 471 M+ +Q IG+GS G LV+ G Y +K I ++ + + R++ +E+ + + Sbjct: 1 MEKYVRLQKIGEGSFGKAVLVKSTEDGRHYVIKEINISRMSDKERQESRREVAVLANMKH 60 Query: 472 PHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLYLH-H 648 P+IV +SF NG +Y+V++Y + G L I K L +L V L H H Sbjct: 61 PNIVQYKESFEENGSLYIVMDYCEGGDLFKRINAQKGALFQEDQILDWFVQICLALKHVH 120 Query: 649 ERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISGSSY 828 +R ++HRDIK N+ + G V++ DFG++ VL S++ T +GT Y++PE Y Sbjct: 121 DRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPY 180 Query: 829 DYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAPADQFSPEFCS 1008 + KSD+W+LG V+ E + + + +L+ I PP +P +S + S Sbjct: 181 NNKSDIWALGCVLYELCTLKHAFEAGNMKNL-----VLKIISGSFPPVSP--HYSYDLRS 233 Query: 1009 FISSCIQKDPAERKSASELLNHAFIKKFEDKDLDLRILVE 1128 +S +++P +R S + +L FI K +K L +++ E Sbjct: 234 LLSQLFKRNPRDRPSVNSILEKGFIAKRIEKFLSPQLIAE 273
>Q6ZN16:M3K15_HUMAN Mitogen-activated protein kinase kinase kinase 15 - Homo sapiens| (Human) Length = 1313 Score = 123 bits (309), Expect = 2e-27 Identities = 95/282 (33%), Positives = 144/282 (51%), Gaps = 4/282 (1%) Frame = +1 Query: 319 VIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQIVQELKINQATQSPHIVLCHQS 498 V+GKG+ G+V R A+K I + + +E+ +++ + +IV S Sbjct: 657 VLGKGTYGIVYAGRDLSNQVRIAIKEIPER-DSRYSQPLHEEIALHKYLKHRNIVQYLGS 715 Query: 499 FYHNGVIYLVLEYMDRGSLADIIKQV-KTILEPYLAVLCKQVLEGLLYLHHERHVIHRDI 675 NG I + +E + GSL+ +++ + EP + KQ+LEGL YLH E ++HRDI Sbjct: 716 VSENGYIKIFMEQVPGGSLSALLRSKWGPMKEPTIKFYTKQILEGLKYLH-ENQIVHRDI 774 Query: 676 KPSNLLVN-HKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISGS--SYDYKSDV 846 K N+LVN + G VKI+DFG S LA +TF GT YMAPE I Y +D+ Sbjct: 775 KGDNVLVNTYSGVVKISDFGTSKRLAGVNPCTETFTGTLQYMAPEIIDQGPRGYGAPADI 834 Query: 847 WSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAPADQFSPEFCSFISSCI 1026 WSLG I+E A + P+ GE + +++ + P A S E +FI SC Sbjct: 835 WSLGCTIIEMATSKPPF-HELGEPQAAMFKVGMFKIHPEIPEA----LSAEARAFILSCF 889 Query: 1027 QKDPAERKSASELLNHAFIKKFEDKDLDLRILVESLEQPMNV 1152 + DP +R + +ELL F+++ +K RI + E P V Sbjct: 890 EPDPHKRATTAELLREGFLRQV-NKGKKNRIAFKPSEGPRGV 930
>Q60823:AKT2_MOUSE RAC-beta serine/threonine-protein kinase - Mus musculus (Mouse)| Length = 481 Score = 123 bits (309), Expect = 2e-27 Identities = 84/299 (28%), Positives = 144/299 (48%), Gaps = 7/299 (2%) Frame = +1 Query: 232 SEENGDEHQSTKMKVEDVQLSMDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMN- 408 S+ + E + +++M+D + ++++GKG+ G V LVR K G +YA+K ++ Sbjct: 128 SDSSTSEMMEVAVNKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEV 187 Query: 409 -IQESVRKQIVQELKINQATQSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTI 585 I + V E ++ Q T+ P + +F + + V+EY + G L + + + Sbjct: 188 IIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVF 247 Query: 586 LEPYLAVLCKQVLEGLLYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQ 765 E +++ L YLH R V++RDIK NL+++ G +KITDFG+ S Sbjct: 248 TEDRARFYGAEIVSALEYLH-SRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGAT 306 Query: 766 RDTFVGTYNYMAPERISGSSYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLE 945 TF GT Y+APE + + Y D W LG+V+ E GR P+ + E +EL+ Sbjct: 307 MKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHE---RLFELIL 363 Query: 946 AIVDQPPPSAPADQFSPEFCSFISSCIQKDPAER-----KSASELLNHAFIKKFEDKDL 1107 + P + PE S ++ ++KDP +R A E++ H F +D+ Sbjct: 364 MEEIRFPRT-----LGPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDV 417
>Q98TY9:AKT1_XENLA RAC-alpha serine/threonine-protein kinase - Xenopus laevis (African| clawed frog) Length = 481 Score = 123 bits (309), Expect = 2e-27 Identities = 80/291 (27%), Positives = 144/291 (49%), Gaps = 8/291 (2%) Frame = +1 Query: 232 SEENGDEHQSTKMKVEDVQLSMDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNI 411 S+ +G E +++M++ E ++++GKG+ G V LV+ K G +YA+K ++ + Sbjct: 127 SDNSGAEEMEVSHSKPKHKVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEV 186 Query: 412 ---QESVRKQIVQELKINQATQSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKT 582 ++ V + + ++ Q ++ P + SF + + V+EY + G L + + + Sbjct: 187 IVAKDEVAHTLTEN-RVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERI 245 Query: 583 ILEPYLAVLCKQVLEGLLYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIG 762 E +++ L YLH E++V++RD+K NL+++ G +KITDFG+ Sbjct: 246 FSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGA 305 Query: 763 QRDTFVGTYNYMAPERISGSSYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELL 942 TF GT Y+APE + + Y D W LG+V+ E GR P+ + E +EL+ Sbjct: 306 TMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHE---KLFELI 362 Query: 943 EAIVDQPPPSAPADQFSPEFCSFISSCIQKDPAER-----KSASELLNHAF 1080 + P + PE S +S ++KDP +R A E++ H F Sbjct: 363 LMEEIRFPRT-----LLPEAKSLLSGLLKKDPKQRLGGGPDDAKEIMQHKF 408
>Q9Y6R4:M3K4_HUMAN Mitogen-activated protein kinase kinase kinase 4 - Homo sapiens| (Human) Length = 1607 Score = 123 bits (308), Expect = 2e-27 Identities = 84/270 (31%), Positives = 142/270 (52%), Gaps = 9/270 (3%) Frame = +1 Query: 322 IGKGSGGVVQLVRHKWVGTFYALKGI--QMNIQESVRKQIVQELKINQATQSPHIVLCHQ 495 IG+G G V G A+K I Q N +++ K+ ELKI + + P++V Sbjct: 1348 IGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTI-KETADELKIFEGIKHPNLVRYFG 1406 Query: 496 SFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLYLHHERHVIHRDI 675 H +Y+ +EY D G+L ++ + + E + + KQ+ + LH E ++HRDI Sbjct: 1407 VELHREEMYIFMEYCDEGTLEEVSRL--GLQEHVIRLYSKQITIAINVLH-EHGIVHRDI 1463 Query: 676 KPSNLLVNHKGEVKITDFGVSAVLASSI----GQRDTFVGTYNYMAPE---RISGSSYDY 834 K +N+ + G +K+ DFG S L ++ G+ ++ +GT YMAPE R G + Sbjct: 1464 KGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVITRAKGEGHGR 1523 Query: 835 KSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAPADQFSPEFCSFI 1014 +D+WSLG V++E G+ P+ E +F + + + PP ++ SPE F+ Sbjct: 1524 AADIWSLGCVVIEMVTGKRPWHEYEH----NFQIMYKVGMGHKPPIP--ERLSPEGKDFL 1577 Query: 1015 SSCIQKDPAERKSASELLNHAFIKKFEDKD 1104 S C++ DP R +AS+LL+H+F+K D++ Sbjct: 1578 SHCLESDPKMRWTASQLLDHSFVKVCTDEE 1607
>P47197:AKT2_RAT RAC-beta serine/threonine-protein kinase - Rattus norvegicus (Rat)| Length = 481 Score = 123 bits (308), Expect = 2e-27 Identities = 84/299 (28%), Positives = 144/299 (48%), Gaps = 7/299 (2%) Frame = +1 Query: 232 SEENGDEHQSTKMKVEDVQLSMDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMN- 408 S+ + E + +++M+D + ++++GKG+ G V LVR K G +YA+K ++ Sbjct: 128 SDSSTSEMMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEV 187 Query: 409 -IQESVRKQIVQELKINQATQSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTI 585 I + V E ++ Q T+ P + +F + + V+EY + G L + + + Sbjct: 188 IIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGDLFFHLSRERVF 247 Query: 586 LEPYLAVLCKQVLEGLLYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQ 765 E +++ L YLH V++RDIK NL+++ G +KITDFG+S S Sbjct: 248 TEDRARFYGAEIVSALEYLH-STDVVYRDIKLENLMLDKDGHIKITDFGLSKEGISDGAT 306 Query: 766 RDTFVGTYNYMAPERISGSSYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLE 945 TF GT Y+APE + + Y D W LG+V+ E GR P+ + E +EL+ Sbjct: 307 MKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHE---RLFELIL 363 Query: 946 AIVDQPPPSAPADQFSPEFCSFISSCIQKDPAER-----KSASELLNHAFIKKFEDKDL 1107 + P + PE S ++ ++KDP +R A E++ H F +D+ Sbjct: 364 MEEIRFPRT-----LGPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDV 417
>P09217:KPCZ_RAT Protein kinase C zeta type - Rattus norvegicus (Rat)| Length = 592 Score = 122 bits (307), Expect = 3e-27 Identities = 93/352 (26%), Positives = 162/352 (46%), Gaps = 31/352 (8%) Frame = +1 Query: 133 VPAQETPVDKFLTASGTFKDGELRLNQRGLQLISEE--------NGDEHQSTKMKVEDVQ 288 +P+QE PVD G+ L SEE + +H + K ED++ Sbjct: 188 MPSQEPPVDD---------------KNDGVDLPSEETDGIAYISSSRKHDNIKDDSEDLK 232 Query: 289 --------------LSMDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNI---QE 417 L + D ++I+VIG+GS V LVR K YA+K ++ + E Sbjct: 233 PVIDGVDGIKISQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDE 292 Query: 418 SVRKQIVQELKINQATQSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPY 597 + ++ QA+ +P +V H F ++LV+EY++ G L +++ + + E + Sbjct: 293 DIDWVQTEKHVFEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEH 352 Query: 598 LAVLCKQVLEGLLYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTF 777 ++ L +LH ER +I+RD+K N+L++ G +K+TD+G+ TF Sbjct: 353 ARFYAAEICIALNFLH-ERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTF 411 Query: 778 VGTYNYMAPERISGSSYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVD 957 GT NY+APE + G Y + D W+LG+++ E GR P+ ++ + L ++ Sbjct: 412 CGTPNYIAPEILRGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVIL 471 Query: 958 QPPPSAPADQFSPEFCSFISSCIQKDPAERKSA------SELLNHAFIKKFE 1095 + P P S + + + KDP ER S++ +HAF + + Sbjct: 472 EKPIRIPR-FLSVKASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSID 522
>P38991:IPL1_YEAST Spindle assembly checkpoint kinase - Saccharomyces cerevisiae| (Baker's yeast) Length = 367 Score = 122 bits (307), Expect = 3e-27 Identities = 76/267 (28%), Positives = 139/267 (52%), Gaps = 2/267 (0%) Frame = +1 Query: 289 LSMDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMN--IQESVRKQIVQELKINQA 462 LS+DD E+ + +GKG G V VRH+ G ALK ++ I+ +++KQ +E++I + Sbjct: 99 LSLDDFELGKKLGKGKFGKVYCVRHRSTGYICALKVMEKEEIIKYNLQKQFRREVEIQTS 158 Query: 463 TQSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLYL 642 P++ + F+ +YL++EY+ G + +++ + + Q+ L Y+ Sbjct: 159 LNHPNLTKSYGYFHDEKRVYLLMEYLVNGEMYKLLRLHGPFNDILASDYIYQIANALDYM 218 Query: 643 HHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISGS 822 H ++++IHRDIKP N+L+ +K+TDFG S ++ +R T GT +Y++PE + Sbjct: 219 H-KKNIIHRDIKPENILIGFNNVIKLTDFGWS-IINPPENRRKTVCGTIDYLSPEMVESR 276 Query: 823 SYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAPADQFSPEF 1002 YD+ D W+LG++ E G P+ E E + Y+ + A+ + P S + Sbjct: 277 EYDHTIDAWALGVLAFELLTGAPPF---EEEMKDTTYKRIAALDIKMP-----SNISQDA 328 Query: 1003 CSFISSCIQKDPAERKSASELLNHAFI 1083 I ++ DP +R ++ H +I Sbjct: 329 QDLILKLLKYDPKDRMRLGDVKMHPWI 355
>Q7ZYJ0:TAO1B_XENLA Serine/threonine-protein kinase TAO1-B - Xenopus laevis (African| clawed frog) Length = 1001 Score = 122 bits (306), Expect = 4e-27 Identities = 85/263 (32%), Positives = 134/263 (50%), Gaps = 6/263 (2%) Frame = +1 Query: 313 IQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRK--QIVQELKINQATQSPHIVL 486 ++ IG GS G V A+K + + ++S K I++E+K Q Q P+ + Sbjct: 31 LREIGHGSFGAVYFAHDARTSEVVAIKKMSYSGKQSNEKWQDIIKEVKFLQRIQHPNSIE 90 Query: 487 CHQSFYHNGVIYLVLEYMDRGSLADIIK-QVKTILEPYLAVLCKQVLEGLLYLHHERHVI 663 + +LV+EY GS +D+++ K + E +A + L+GL YLH ++I Sbjct: 91 YKGCYLREHTAWLVMEYC-LGSASDLLEVHKKPLQEIEIAAITHGALQGLAYLH-SHNLI 148 Query: 664 HRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERI---SGSSYDY 834 HRDIK N+L+ G+VK+ DFG AS + ++FVGT +MAPE I YD Sbjct: 149 HRDIKAGNILLTEPGQVKLADFG----SASIVSPANSFVGTPYWMAPEVILAMDEGQYDG 204 Query: 835 KSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAPADQFSPEFCSFI 1014 K DVWSLG+ +E A + P ++ L I P+ + ++S F +F+ Sbjct: 205 KVDVWSLGITCVELAERKPPLFN------MNAMSALYHIAQNESPTLQSTEWSDYFRNFV 258 Query: 1015 SSCIQKDPAERKSASELLNHAFI 1083 SC+ K P +R ++ ELL H F+ Sbjct: 259 DSCLHKIPQDRPTSDELLKHMFV 281
>Q02956:KPCZ_MOUSE Protein kinase C zeta type - Mus musculus (Mouse)| Length = 592 Score = 122 bits (306), Expect = 4e-27 Identities = 93/352 (26%), Positives = 162/352 (46%), Gaps = 31/352 (8%) Frame = +1 Query: 133 VPAQETPVDKFLTASGTFKDGELRLNQRGLQLISEE--------NGDEHQSTKMKVEDVQ 288 +P+QE PVD G+ L SEE + +H + K ED++ Sbjct: 188 MPSQEPPVDG---------------KNDGVDLPSEETDGIAYISSSRKHDNIKDDSEDLK 232 Query: 289 --------------LSMDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNI---QE 417 L + D ++I+VIG+GS V LVR K YA+K ++ + E Sbjct: 233 PVIDGVDGIKISQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDE 292 Query: 418 SVRKQIVQELKINQATQSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPY 597 + ++ QA+ +P +V H F ++LV+EY++ G L +++ + + E + Sbjct: 293 DIDWVQTEKHVFEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEH 352 Query: 598 LAVLCKQVLEGLLYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTF 777 ++ L +LH ER +I+RD+K N+L++ G +K+TD+G+ TF Sbjct: 353 ARFYAAEICIALNFLH-ERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTF 411 Query: 778 VGTYNYMAPERISGSSYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVD 957 GT NY+APE + G Y + D W+LG+++ E GR P+ ++ + L ++ Sbjct: 412 CGTPNYIAPEILRGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVIL 471 Query: 958 QPPPSAPADQFSPEFCSFISSCIQKDPAERKSA------SELLNHAFIKKFE 1095 + P P S + + + KDP ER S++ +HAF + + Sbjct: 472 EKPIRIPR-FLSVKASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSID 522
>P32562:CDC5_YEAST Cell cycle serine/threonine-protein kinase CDC5/MSD2 - Saccharomyces| cerevisiae (Baker's yeast) Length = 705 Score = 122 bits (306), Expect = 4e-27 Identities = 96/340 (28%), Positives = 167/340 (49%), Gaps = 16/340 (4%) Frame = +1 Query: 115 KELTLSVPAQETPVDKFLTASGTFKDGELRLNQRGLQLISEENGDEHQSTKMKVEDVQLS 294 K+L TP+ K TA K+ + +R + N D H K + +LS Sbjct: 12 KQLNTRSKLVHTPI-KGNTADLVGKENHFKQTKR-----LDPNNDHHHQPAQKKKREKLS 65 Query: 295 M---DDLEMIQVIGK--------GSGGVVQLVRHKW-VGTFYALKGI-QMNIQ-ESVRKQ 432 +I+ GK G GG + + K G +A K + + +I+ E RK+ Sbjct: 66 ALCKTPPSLIKTRGKDYHRGHFLGEGGFARCFQIKDDSGEIFAAKTVAKASIKSEKTRKK 125 Query: 433 IVQELKINQATQSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLC 612 ++ E++I+++ P+IV F + +Y++LE GSL +++K+ K + EP + Sbjct: 126 LLSEIQIHKSMSHPNIVQFIDCFEDDSNVYILLEICPNGSLMELLKRRKVLTEPEVRFFT 185 Query: 613 KQVLEGLLYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYN 792 Q+ + Y+H R VIHRD+K N+ + +KI DFG++AVLA+ ++ T GT N Sbjct: 186 TQICGAIKYMH-SRRVIHRDLKLGNIFFDSNYNLKIGDFGLAAVLANESERKYTICGTPN 244 Query: 793 YMAPERISG--SSYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPP 966 Y+APE + G S + ++ D+WSLG+++ IG+ P+ + + YE ++ P Sbjct: 245 YIAPEVLMGKHSGHSFEVDIWSLGVMLYALLIGKPPF---QARDVNTIYERIKCRDFSFP 301 Query: 967 PSAPADQFSPEFCSFISSCIQKDPAERKSASELLNHAFIK 1086 P S E I + DP ER S +E++++ + + Sbjct: 302 RDKP---ISDEGKILIRDILSLDPIERPSLTEIMDYVWFR 338
>O88445:AURKC_MOUSE Serine/threonine-protein kinase 13 - Mus musculus (Mouse)| Length = 282 Score = 122 bits (306), Expect = 4e-27 Identities = 83/268 (30%), Positives = 142/268 (52%), Gaps = 2/268 (0%) Frame = +1 Query: 292 SMDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNI--QESVRKQIVQELKINQAT 465 +++D E+ + +G+G G V L R K ALK + + +E + Q+ +E++I Sbjct: 12 TINDFEIGRPLGRGKFGRVYLARLKENHFIVALKVLFKSEIEKEGLEHQLRREVEIQAHL 71 Query: 466 QSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLYLH 645 Q +I+ + FY + IYL+LEY G L +++ + + + A + +++ + L Y H Sbjct: 72 QHRNILRLYNYFYDDTRIYLILEYAPGGELYKELQRHQKLDQQRTATIIQELSDALTYCH 131 Query: 646 HERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISGSS 825 E+ VIHRDIKP NLL+ GEVKI+DFG S S +R T GT +Y+ PE I+ Sbjct: 132 -EKKVIHRDIKPENLLLGLNGEVKISDFGWSVHTPSL--RRKTMCGTLDYLPPEMIAQKP 188 Query: 826 YDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAPADQFSPEFC 1005 Y+ D+W +G++ E +G+ P+ E Y + + + P S PA Sbjct: 189 YNEMVDLWCIGVLCYELLVGKPPF---ESSTSSETYRRIRQVDFKFPSSVPAGA-----Q 240 Query: 1006 SFISSCIQKDPAERKSASELLNHAFIKK 1089 IS ++ P+ER S +++L H ++++ Sbjct: 241 DLISKLLRYHPSERLSLAQVLKHPWVRE 268
>Q9H2K8:TAOK3_HUMAN Serine/threonine-protein kinase TAO3 - Homo sapiens (Human)| Length = 898 Score = 122 bits (305), Expect = 5e-27 Identities = 87/279 (31%), Positives = 146/279 (52%), Gaps = 6/279 (2%) Frame = +1 Query: 322 IGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRK--QIVQELKINQATQSPHIVLCHQ 495 IG GS G V + A+K + + +++ K I++E+K + + P+ + Sbjct: 30 IGHGSFGAVYFATNAHTSEVVAIKKMSYSGKQTHEKWQDILKEVKFLRQLKHPNTIEYKG 89 Query: 496 SFYHNGVIYLVLEYMDRGSLADIIK-QVKTILEPYLAVLCKQVLEGLLYLHHERHVIHRD 672 + +LV+EY GS +D+++ K + E +A + L GL YLH +IHRD Sbjct: 90 CYLKEHTAWLVMEYC-LGSASDLLEVHKKPLQEVEIAAITHGALHGLAYLHSHA-LIHRD 147 Query: 673 IKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISG---SSYDYKSD 843 IK N+L+ G+VK+ DFG SA +AS ++FVGT +MAPE I YD K D Sbjct: 148 IKAGNILLTEPGQVKLADFG-SASMASPA---NSFVGTPYWMAPEVILAMDEGQYDGKVD 203 Query: 844 VWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAPADQFSPEFCSFISSC 1023 +WSLG+ +E A + P ++ L I P+ +++++ F F+ C Sbjct: 204 IWSLGITCIELAERKPPLFN------MNAMSALYHIAQNDSPTLQSNEWTDSFRRFVDYC 257 Query: 1024 IQKDPAERKSASELLNHAFIKKFEDKDLDLRILVESLEQ 1140 +QK P ER +++ELL H F++ +D LR+L++ +++ Sbjct: 258 LQKIPQERPTSAELLRHDFVR----RDRPLRVLIDLIQR 292
>Q9XT18:SGK1_RABIT Serine/threonine-protein kinase Sgk1 - Oryctolagus cuniculus (Rabbit)| Length = 431 Score = 122 bits (305), Expect = 5e-27 Identities = 84/276 (30%), Positives = 133/276 (48%), Gaps = 7/276 (2%) Frame = +1 Query: 301 DLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMN--IQESVRKQIVQELKIN-QATQS 471 D ++VIGKGS G V L RHK FYA+K +Q +++ K I+ E + + + Sbjct: 97 DFHFLKVIGKGSFGKVLLARHKAEEAFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKH 156 Query: 472 PHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLYLHHE 651 P +V H SF +Y VL+Y++ G L +++ + LEP ++ L YLH Sbjct: 157 PFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLH-S 215 Query: 652 RHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISGSSYD 831 ++++RD+KP N+L++ +G + +TDFG+ G TF GT Y+APE + YD Sbjct: 216 LNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNGTTSTFCGTPEYLAPEVLHKQPYD 275 Query: 832 YKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAPADQFSPEFCSF 1011 D W LG V+ E G P+ + E+ + I+++P P + Sbjct: 276 RTVDWWCLGAVLYEMLYGLPPFYS------RNTAEMYDNILNKPLQLKP--NITNSARHL 327 Query: 1012 ISSCIQKDPAERKSAS----ELLNHAFIKKFEDKDL 1107 + +QKD +R A E+ NH F DL Sbjct: 328 LEGLLQKDRTKRLGAKDDFMEIRNHVFFSLINWDDL 363
>P50528:PLO1_SCHPO Serine/threonine-protein kinase plo1 - Schizosaccharomyces pombe| (Fission yeast) Length = 683 Score = 121 bits (304), Expect = 6e-27 Identities = 83/255 (32%), Positives = 138/255 (54%), Gaps = 5/255 (1%) Frame = +1 Query: 331 GSGGVVQLVRHKW-VGTFYALKGI-QMNIQESVRK-QIVQELKINQATQSPHIVLCHQSF 501 G GG + R K G YA K I + ++Q K ++ E+K++Q+ P+IV F Sbjct: 48 GEGGFARCFRVKDNYGNIYAAKVIAKRSLQNDKTKLKLFGEIKVHQSMSHPNIVGFIDCF 107 Query: 502 YHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLYLHHERHVIHRDIKP 681 + IYL+LE + SL +++++ K + EP + L Q+L L Y+H +R VIHRD+K Sbjct: 108 EDSTNIYLILELCEHKSLMELLRKRKQLTEPEVRYLMMQILGALKYMHKKR-VIHRDLKL 166 Query: 682 SNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERI--SGSSYDYKSDVWSL 855 N++++ VKI DFG++A+L ++ T GT NY+APE + S + ++ D+WS Sbjct: 167 GNIMLDESNNVKIGDFGLAALLMDDEERKMTICGTPNYIAPEILFNSKEGHSFEVDLWSA 226 Query: 856 GLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAPADQFSPEFCSFISSCIQKD 1035 G+V+ IG+ P+ E + + Y ++A P + S E ISS + D Sbjct: 227 GVVMYALLIGKPPFQDKEVK---TIYRKIKANSYSFPSNV---DISAEAKDLISSLLTHD 280 Query: 1036 PAERKSASELLNHAF 1080 P+ R S ++++H F Sbjct: 281 PSIRPSIDDIVDHEF 295
>O22040:ANP1_ARATH Mitogen-activated protein kinase kinase kinase ANP1 - Arabidopsis| thaliana (Mouse-ear cress) Length = 666 Score = 121 bits (304), Expect = 6e-27 Identities = 87/294 (29%), Positives = 153/294 (52%), Gaps = 17/294 (5%) Frame = +1 Query: 316 QVIGKGSGGVVQLVRHKWVGTFYALKGI------------QMNIQESVRKQIVQELKINQ 459 Q+IG+G+ G V + + G A+K + Q +IQE + +E+K+ + Sbjct: 73 QLIGRGAFGTVYMGMNLDSGELLAVKQVLIAANFASKEKTQAHIQE-----LEEEVKLLK 127 Query: 460 ATQSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLY 639 P+IV + + + ++LE++ GS++ ++++ E + +Q+L GL Y Sbjct: 128 NLSHPNIVRYLGTVREDDTLNILLEFVPGGSISSLLEKFGPFPESVVRTYTRQLLLGLEY 187 Query: 640 LHHERHVIHRDIKPSNLLVNHKGEVKITDFGVS---AVLASSIGQRDTFVGTYNYMAPER 810 LH+ ++HRDIK +N+LV++KG +K+ DFG S A LA+ G + + GT +MAPE Sbjct: 188 LHNHA-IMHRDIKGANILVDNKGCIKLADFGASKQVAELATMTGAK-SMKGTPYWMAPEV 245 Query: 811 ISGSSYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAPADQF 990 I + + + +D+WS+G ++E G+ P++ E F+ + PP D Sbjct: 246 ILQTGHSFSADIWSVGCTVIEMVTGKAPWSQQYKEVAAIFF--IGTTKSHPP---IPDTL 300 Query: 991 SPEFCSFISSCIQKDPAERKSASELLNHAFI--KKFEDKDLDLRILVESLEQPM 1146 S + F+ C+Q+ P R +ASELL H F+ K E DL ++ +L P+ Sbjct: 301 SSDAKDFLLKCLQEVPNLRPTASELLKHPFVMGKHKESASTDLGSVLNNLSTPL 354
>Q9R012:PLK2_RAT Serine/threonine-protein kinase PLK2 - Rattus norvegicus (Rat)| Length = 682 Score = 121 bits (303), Expect = 8e-27 Identities = 71/221 (32%), Positives = 119/221 (53%), Gaps = 2/221 (0%) Frame = +1 Query: 424 RKQIVQELKINQATQSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLA 603 R++I +E+++++ H+V + F IY++LEY R S+A I+K K + EP + Sbjct: 121 REKIDKEIELHRILHHKHVVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVR 180 Query: 604 VLCKQVLEGLLYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVG 783 +Q++ GL YLH E+ ++HRD+K N +N E+K+ DFG++A L +R T G Sbjct: 181 YYLRQIVSGLKYLH-EQEILHRDLKLGNFFINEAMELKVGDFGLAARLEPLEHRRRTICG 239 Query: 784 TYNYMAPERISGSSYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQP 963 T NY++PE ++ + +SD+W+LG V+ +GR P+ E Y + Sbjct: 240 TPNYLSPEVLNKQGHGCESDIWALGCVMYTMLLGRPPF---ETTNLKETYRCIREARYTM 296 Query: 964 PPS--APADQFSPEFCSFISSCIQKDPAERKSASELLNHAF 1080 P S APA I+S + K+P +R S +++ H F Sbjct: 297 PSSLLAPAKH-------LIASMLSKNPEDRPSLDDIIRHDF 330
>Q5R4L1:PLK2_PONPY Serine/threonine-protein kinase PLK2 - Pongo pygmaeus (Orangutan)| Length = 685 Score = 121 bits (303), Expect = 8e-27 Identities = 71/221 (32%), Positives = 119/221 (53%), Gaps = 2/221 (0%) Frame = +1 Query: 424 RKQIVQELKINQATQSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLA 603 R++I +E+++++ H+V + F IY++LEY R S+A I+K K + EP + Sbjct: 124 REKIDKEIELHRILHHKHVVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVR 183 Query: 604 VLCKQVLEGLLYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVG 783 +Q++ GL YLH E+ ++HRD+K N +N E+K+ DFG++A L +R T G Sbjct: 184 YYLRQIVSGLKYLH-EQEILHRDLKLGNFFINEAMELKVGDFGLAARLEPLEHRRRTICG 242 Query: 784 TYNYMAPERISGSSYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQP 963 T NY++PE ++ + +SD+W+LG V+ +GR P+ E Y + Sbjct: 243 TPNYLSPEVLNKQGHGCESDIWALGCVMYTMLLGRPPF---ETTNLKETYRCIREARYTM 299 Query: 964 PPS--APADQFSPEFCSFISSCIQKDPAERKSASELLNHAF 1080 P S APA I+S + K+P +R S +++ H F Sbjct: 300 PSSLLAPAKH-------LIASMLSKNPEDRPSLDDIIRHDF 333
>P53351:PLK2_MOUSE Serine/threonine-protein kinase PLK2 - Mus musculus (Mouse)| Length = 682 Score = 121 bits (303), Expect = 8e-27 Identities = 71/221 (32%), Positives = 119/221 (53%), Gaps = 2/221 (0%) Frame = +1 Query: 424 RKQIVQELKINQATQSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLA 603 R++I +E+++++ H+V + F IY++LEY R S+A I+K K + EP + Sbjct: 121 REKIDKEIELHRLLHHKHVVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVR 180 Query: 604 VLCKQVLEGLLYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVG 783 +Q++ GL YLH E+ ++HRD+K N +N E+K+ DFG++A L +R T G Sbjct: 181 YYLRQIVSGLKYLH-EQEILHRDLKLGNFFINEAMELKVGDFGLAARLEPLEHRRRTICG 239 Query: 784 TYNYMAPERISGSSYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQP 963 T NY++PE ++ + +SD+W+LG V+ +GR P+ E Y + Sbjct: 240 TPNYLSPEVLNKQGHGCESDIWALGCVMYTMLLGRPPF---ETTNLKETYRCIREARYTM 296 Query: 964 PPS--APADQFSPEFCSFISSCIQKDPAERKSASELLNHAF 1080 P S APA I+S + K+P +R S +++ H F Sbjct: 297 PSSLLAPAKH-------LIASMLSKNPEDRPSLDDIIRHDF 330
>Q9NYY3:PLK2_HUMAN Serine/threonine-protein kinase PLK2 - Homo sapiens (Human)| Length = 685 Score = 121 bits (303), Expect = 8e-27 Identities = 71/221 (32%), Positives = 119/221 (53%), Gaps = 2/221 (0%) Frame = +1 Query: 424 RKQIVQELKINQATQSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLA 603 R++I +E+++++ H+V + F IY++LEY R S+A I+K K + EP + Sbjct: 124 REKIDKEIELHRILHHKHVVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVR 183 Query: 604 VLCKQVLEGLLYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVG 783 +Q++ GL YLH E+ ++HRD+K N +N E+K+ DFG++A L +R T G Sbjct: 184 YYLRQIVSGLKYLH-EQEILHRDLKLGNFFINEAMELKVGDFGLAARLEPLEHRRRTICG 242 Query: 784 TYNYMAPERISGSSYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQP 963 T NY++PE ++ + +SD+W+LG V+ +GR P+ E Y + Sbjct: 243 TPNYLSPEVLNKQGHGCESDIWALGCVMYTMLLGRPPF---ETTNLKETYRCIREARYTM 299 Query: 964 PPS--APADQFSPEFCSFISSCIQKDPAERKSASELLNHAF 1080 P S APA I+S + K+P +R S +++ H F Sbjct: 300 PSSLLAPAKH-------LIASMLSKNPEDRPSLDDIIRHDF 333
>Q61XD3:AIR2_CAEBR Aurora/Ipl1-related protein kinase 2 - Caenorhabditis briggsae| Length = 302 Score = 121 bits (303), Expect = 8e-27 Identities = 84/273 (30%), Positives = 135/273 (49%), Gaps = 2/273 (0%) Frame = +1 Query: 286 QLSMDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMN--IQESVRKQIVQELKINQ 459 +LS++D E+ + +GKG G V L R K A+K + + I V Q+ +E++I Sbjct: 21 KLSINDFEIGRPLGKGKFGSVYLARTKTGHFHCAIKVLFKSQLISGGVEHQLEREIEIQS 80 Query: 460 ATQSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLY 639 Q P+I+ + F+ IYL+LEY G + + K E ++ + L Y Sbjct: 81 HLQHPNIIRLYNYFWDAKKIYLILEYAPGGEMYKQLTTQKRFTEAMAGKYMYEIADALSY 140 Query: 640 LHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISG 819 H ++VIHRDIKP NLL+ +GE+KI DFG S S+ +R T GT +Y+ PE ++G Sbjct: 141 CHR-KNVIHRDIKPENLLIGAQGELKIGDFGWSVHAPSN--KRQTMCGTMDYLPPEMVNG 197 Query: 820 SSYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAPADQFSPE 999 +S+ D+W++G++ E +G+ P+ E E Y ++A P D Sbjct: 198 NSHSDAVDLWAIGVLCYEFLVGKPPF---EHENQADTYSAIKAGRFTYP-----DFVKKG 249 Query: 1000 FCSFISSCIQKDPAERKSASELLNHAFIKKFED 1098 I + DP R S E+ +H ++ D Sbjct: 250 ARDLIGKLLVVDPRRRCSLQEVKDHYWVTSMLD 282
>P28178:PK2_DICDI Protein kinase 2 - Dictyostelium discoideum (Slime mold)| Length = 479 Score = 120 bits (302), Expect = 1e-26 Identities = 93/363 (25%), Positives = 172/363 (47%), Gaps = 23/363 (6%) Frame = +1 Query: 91 AMRGKKPLKELTLSVPAQETPVDKFLTASGTFKDGELRLNQRGLQLISEE---------- 240 ++ K+ ++ + PA +TP+ + T + T ++ + + + S E Sbjct: 67 SLDNKEQQQQQNIPAPATQTPITQ--TGTPTIEESQKNTDNNNINGASNEASSSPDSPNG 124 Query: 241 ----NGDEHQSTKMKV---EDVQLSMDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGI 399 N DE + + + + DD E++ VIGKGS G V V+ K +A+K + Sbjct: 125 SGNGNDDEDEGPEEVIFSKNKQSATKDDFELLNVIGKGSFGKVMQVKKKGEDKIFAMKVL 184 Query: 400 QMNIQESVRKQI---VQELKINQATQSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIK 570 + + + RKQ+ E I Q P IV H +F +Y+VL++++ G L +K Sbjct: 185 RKDAIIA-RKQVNHTKSEKTILQCISHPFIVNLHYAFQTKDKLYMVLDFVNGGELFFHLK 243 Query: 571 QVKTILEPYLAVLCKQVLEGLLYLHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLA 750 + EP + + +++ L +LH ++ +++RD+KP N+L++ +G + ITDFG+S + Sbjct: 244 REGRFSEPRVKIYAAEIVSALDHLH-KQDIVYRDLKPENILLDSEGHICITDFGLSKKIE 302 Query: 751 SSIGQRDTFVGTYNYMAPERISGSSYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSF 930 ++ G TF GT Y+APE ++G + D WSLG ++ E G P+ + Sbjct: 303 TTDG-TFTFCGTPEYLAPEVLNGHGHGCAVDWWSLGTLLYEMLTGLPPFYSQNVS--TMY 359 Query: 931 YELLEAIVDQPPPSAPADQFSPEFCSFISSCIQKDPAER---KSASELLNHAFIKKFEDK 1101 ++L + P SPE S + + ++ +R K E+ H + K + + Sbjct: 360 QKILNGELKIP------TYISPEAKSLLEGLLTREVDKRLGTKGGGEVKQHPWFKNIDWE 413 Query: 1102 DLD 1110 LD Sbjct: 414 KLD 416
>Q5R4K9:KPCI_PONPY Protein kinase C iota type - Pongo pygmaeus (Orangutan)| Length = 587 Score = 120 bits (302), Expect = 1e-26 Identities = 87/305 (28%), Positives = 146/305 (47%), Gaps = 16/305 (5%) Frame = +1 Query: 289 LSMDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQ---MNIQESVRKQIVQELKINQ 459 L + D ++++VIG+GS V LVR K YA+K ++ +N E + ++ Q Sbjct: 240 LGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQ 299 Query: 460 ATQSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLY 639 A+ P +V H F ++ V+EY++ G L +++ + + E + ++ L Y Sbjct: 300 ASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNY 359 Query: 640 LHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISG 819 LH ER +I+RD+K N+L++ +G +K+TD+G+ TF GT NY+APE + G Sbjct: 360 LH-ERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRG 418 Query: 820 SSYDYKSDVWSLGLVILECAIGRFPY-------TPPEGEGWLSFYELLEAIVDQPPPSAP 978 Y + D W+LG+++ E GR P+ P + F +LE + P Sbjct: 419 EDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIP----- 473 Query: 979 ADQFSPEFCSFISSCIQKDPAERKSA------SELLNHAFIKKFEDKDLDLRILVESLEQ 1140 S + S + S + KDP ER +++ H F F + D D+ +EQ Sbjct: 474 -RSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPF---FRNVDWDM------MEQ 523 Query: 1141 PMNVP 1155 VP Sbjct: 524 KQVVP 528
>Q62074:KPCI_MOUSE Protein kinase C iota type - Mus musculus (Mouse)| Length = 586 Score = 120 bits (302), Expect = 1e-26 Identities = 87/305 (28%), Positives = 146/305 (47%), Gaps = 16/305 (5%) Frame = +1 Query: 289 LSMDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQ---MNIQESVRKQIVQELKINQ 459 L + D ++++VIG+GS V LVR K YA+K ++ +N E + ++ Q Sbjct: 239 LGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQ 298 Query: 460 ATQSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLY 639 A+ P +V H F ++ V+EY++ G L +++ + + E + ++ L Y Sbjct: 299 ASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNY 358 Query: 640 LHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISG 819 LH ER +I+RD+K N+L++ +G +K+TD+G+ TF GT NY+APE + G Sbjct: 359 LH-ERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRG 417 Query: 820 SSYDYKSDVWSLGLVILECAIGRFPY-------TPPEGEGWLSFYELLEAIVDQPPPSAP 978 Y + D W+LG+++ E GR P+ P + F +LE + P Sbjct: 418 EDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIP----- 472 Query: 979 ADQFSPEFCSFISSCIQKDPAERKSA------SELLNHAFIKKFEDKDLDLRILVESLEQ 1140 S + S + S + KDP ER +++ H F F + D D+ +EQ Sbjct: 473 -RSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPF---FRNVDWDM------MEQ 522 Query: 1141 PMNVP 1155 VP Sbjct: 523 KQVVP 527
>P41743:KPCI_HUMAN Protein kinase C iota type - Homo sapiens (Human)| Length = 587 Score = 120 bits (302), Expect = 1e-26 Identities = 87/305 (28%), Positives = 146/305 (47%), Gaps = 16/305 (5%) Frame = +1 Query: 289 LSMDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQ---MNIQESVRKQIVQELKINQ 459 L + D ++++VIG+GS V LVR K YA+K ++ +N E + ++ Q Sbjct: 240 LGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQ 299 Query: 460 ATQSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLY 639 A+ P +V H F ++ V+EY++ G L +++ + + E + ++ L Y Sbjct: 300 ASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNY 359 Query: 640 LHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISG 819 LH ER +I+RD+K N+L++ +G +K+TD+G+ TF GT NY+APE + G Sbjct: 360 LH-ERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRG 418 Query: 820 SSYDYKSDVWSLGLVILECAIGRFPY-------TPPEGEGWLSFYELLEAIVDQPPPSAP 978 Y + D W+LG+++ E GR P+ P + F +LE + P Sbjct: 419 EDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIP----- 473 Query: 979 ADQFSPEFCSFISSCIQKDPAERKSA------SELLNHAFIKKFEDKDLDLRILVESLEQ 1140 S + S + S + KDP ER +++ H F F + D D+ +EQ Sbjct: 474 -RSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPF---FRNVDWDM------MEQ 523 Query: 1141 PMNVP 1155 VP Sbjct: 524 KQVVP 528
>Q4FZD7:PLK5_MOUSE Serine/threonine-protein kinase PLK5 - Mus musculus (Mouse)| Length = 595 Score = 120 bits (301), Expect = 1e-26 Identities = 82/260 (31%), Positives = 130/260 (50%), Gaps = 2/260 (0%) Frame = +1 Query: 316 QVIGKGSGGVVQLVRHKWVGTFYALKGIQMNI--QESVRKQIVQELKINQATQSPHIVLC 489 ++IGKG+ + +ALK + + +R ++ +E+ ++ + +IV Sbjct: 31 KLIGKGAFSRCYKLTDMSTSAVFALKVVPRGGAGRLRLRGKVEREIALHSRLRHRNIVAF 90 Query: 490 HQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLYLHHERHVIHR 669 H F +Y+VLEY R SLA ++K +T+ EP + + ++ GL YLH +R ++HR Sbjct: 91 HAHFADRDHVYMVLEYCSRQSLAHVLKVRRTLTEPEVRYYLRGLVSGLRYLHQQR-IVHR 149 Query: 670 DIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISGSSYDYKSDVW 849 D+KPSN +N EVKI D G++A + + GT N+ APE +S + + KSD+W Sbjct: 150 DLKPSNFFLNKNMEVKIGDLGLAARVGPAGRCHRVLCGTPNFQAPEVVSRNGHSCKSDIW 209 Query: 850 SLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAPADQFSPEFCSFISSCIQ 1029 +LG ++ G TPP LS E+ + I D SP S I+ + Sbjct: 210 ALGCIMYTVLTG----TPPFAAAPLS--EMYQNIRD--GHYLEPTHLSPSARSLIARLLA 261 Query: 1030 KDPAERKSASELLNHAFIKK 1089 DPAER S LL F + Sbjct: 262 PDPAERPSLDHLLQDDFFSQ 281
>P27636:CDC15_YEAST Cell division control protein 15 - Saccharomyces cerevisiae (Baker's| yeast) Length = 974 Score = 120 bits (301), Expect = 1e-26 Identities = 91/266 (34%), Positives = 129/266 (48%), Gaps = 1/266 (0%) Frame = +1 Query: 316 QVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQIVQELKINQATQSPHIVLCHQ 495 QVIG+GS GVV +K A+K + E + I+ E+ + + +IV H Sbjct: 29 QVIGRGSYGVVYKAINKHTDQVVAIKEVVYENDEELN-DIMAEISLLKNLNHNNIVKYHG 87 Query: 496 SFYHNGVIYLVLEYMDRGSLADIIKQVKTIL-EPYLAVLCKQVLEGLLYLHHERHVIHRD 672 + +Y++LEY GSL +I + T L E Q L GL YLH E VIHRD Sbjct: 88 FIRKSYELYILLEYCANGSLRRLISRSSTGLSENESKTYVTQTLLGLKYLHGEG-VIHRD 146 Query: 673 IKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISGSSYDYKSDVWS 852 IK +N+L++ VK+ DFGVS ++ SS T GT N+MAPE + SD+WS Sbjct: 147 IKAANILLSADNTVKLADFGVSTIVNSS---ALTLAGTLNWMAPEILGNRGASTLSDIWS 203 Query: 853 LGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAPADQFSPEFCSFISSCIQK 1032 LG ++E PY + Y +E PP S FS F+S C K Sbjct: 204 LGATVVEMLTKNPPY---HNLTDANIYYAVENDTYYPPSS-----FSEPLKDFLSKCFVK 255 Query: 1033 DPAERKSASELLNHAFIKKFEDKDLD 1110 + +R +A +LL H +I E+ +D Sbjct: 256 NMYKRPTADQLLKHVWINSTENVKVD 281
>Q96PY6:NEK1_HUMAN Serine/threonine-protein kinase Nek1 - Homo sapiens (Human)| Length = 1258 Score = 120 bits (300), Expect = 2e-26 Identities = 85/282 (30%), Positives = 142/282 (50%), Gaps = 4/282 (1%) Frame = +1 Query: 295 MDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESV-RKQIVQELKINQATQS 471 M+ +Q IG+GS G LV+ G Y +K I ++ S R++ +E+ + + Sbjct: 1 MEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKH 60 Query: 472 PHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLYLH-H 648 P+IV +SF NG +Y+V++Y + G L I K +L +L V L H H Sbjct: 61 PNIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVH 120 Query: 649 ERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISGSSY 828 +R ++HRDIK N+ + G V++ DFG++ VL S++ T +GT Y++PE Y Sbjct: 121 DRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPY 180 Query: 829 DYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQ--PPPSAPADQFSPEF 1002 + KSD+W+LG V+ E + + S L+ I+ PP S +S + Sbjct: 181 NNKSDIWALGCVLYELCTLKHAFEAG------SMKNLVLKIISGSFPPVSL---HYSYDL 231 Query: 1003 CSFISSCIQKDPAERKSASELLNHAFIKKFEDKDLDLRILVE 1128 S +S +++P +R S + +L FI K +K L +++ E Sbjct: 232 RSLVSQLFKRNPRDRPSVNSILEKGFIAKRIEKFLSPQLIAE 273
>Q9FZ36:M3K2_ARATH Mitogen-activated protein kinase kinase kinase 2 - Arabidopsis| thaliana (Mouse-ear cress) Length = 651 Score = 120 bits (300), Expect = 2e-26 Identities = 85/297 (28%), Positives = 153/297 (51%), Gaps = 20/297 (6%) Frame = +1 Query: 316 QVIGKGSGGVVQLVRHKWVGTFYALKGI------------QMNIQESVRKQIVQELKINQ 459 Q+IG+G+ G V + + G A+K + Q +IQE + +E+K+ + Sbjct: 72 QLIGRGAFGTVYMGMNLDSGELLAVKQVLITSNCASKEKTQAHIQE-----LEEEVKLLK 126 Query: 460 ATQSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLY 639 P+IV + + + ++LE++ GS++ ++++ E + Q+L GL Y Sbjct: 127 NLSHPNIVRYLGTVREDETLNILLEFVPGGSISSLLEKFGAFPESVVRTYTNQLLLGLEY 186 Query: 640 LHHERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLA--SSIGQRDTFVGTYNYMAPERI 813 LH+ ++HRDIK +N+LV+++G +K+ DFG S +A ++I + GT +MAPE I Sbjct: 187 LHNHA-IMHRDIKGANILVDNQGCIKLADFGASKQVAELATISGAKSMKGTPYWMAPEVI 245 Query: 814 SGSSYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAI----VDQPPPSAPA 981 + + + +D+WS+G ++E G+ P W Y+ + AI + P P Sbjct: 246 LQTGHSFSADIWSVGCTVIEMVTGKAP--------WSQQYKEIAAIFHIGTTKSHPPIP- 296 Query: 982 DQFSPEFCSFISSCIQKDPAERKSASELLNHAFI--KKFEDKDLDLRILVESLEQPM 1146 D S + F+ C+Q++P R +ASELL H F+ K+ E DL +++ P+ Sbjct: 297 DNISSDANDFLLKCLQQEPNLRPTASELLKHPFVTGKQKESASKDLTSFMDNSCSPL 353
>Q39008:M3K1_ARATH Mitogen-activated protein kinase kinase kinase 1 - Arabidopsis| thaliana (Mouse-ear cress) Length = 608 Score = 120 bits (300), Expect = 2e-26 Identities = 86/266 (32%), Positives = 143/266 (53%), Gaps = 8/266 (3%) Frame = +1 Query: 316 QVIGKGS-GGVVQLVRHKWVGTFYALKGIQMNIQESVRKQIVQ----ELKINQATQSPHI 480 Q++G+GS G V + + G F+A+K + + Q S ++ +Q E+K+ Q +I Sbjct: 337 QLLGRGSFGSVYEGISGD--GDFFAVKEVSLLDQGSQAQECIQQLEGEIKLLSQLQHQNI 394 Query: 481 VLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLYLHHERHV 660 V + +Y+ LE + +GSL + ++ + + + +++ +Q+L+GL YLH ++ Sbjct: 395 VRYRGTAKDGSNLYIFLELVTQGSLLKLYQRYQ-LRDSVVSLYTRQILDGLKYLH-DKGF 452 Query: 661 IHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPE---RISGSSYD 831 IHRDIK +N+LV+ G VK+ DFG++ V S + GT +MAPE R Y Sbjct: 453 IHRDIKCANILVDANGAVKLADFGLAKV--SKFNDIKSCKGTPFWMAPEVINRKDSDGYG 510 Query: 832 YKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAPADQFSPEFCSF 1011 +D+WSLG +LE G+ PY+ L + L I P P D S + F Sbjct: 511 SPADIWSLGCTVLEMCTGQIPYSD------LEPVQALFRIGRGTLPEVP-DTLSLDARLF 563 Query: 1012 ISSCIQKDPAERKSASELLNHAFIKK 1089 I C++ +P ER +A+ELLNH F+++ Sbjct: 564 ILKCLKVNPEERPTAAELLNHPFVRR 589
>P12370:KAPC_DROME cAMP-dependent protein kinase catalytic subunit - Drosophila| melanogaster (Fruit fly) Length = 353 Score = 120 bits (300), Expect = 2e-26 Identities = 70/204 (34%), Positives = 114/204 (55%), Gaps = 2/204 (0%) Frame = +1 Query: 292 SMDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGI--QMNIQESVRKQIVQELKINQAT 465 ++DD E I+ +G GS G V +V+HK +YA+K + Q ++ + + E +I QA Sbjct: 42 ALDDFERIKTLGTGSFGRVMIVQHKPTKDYYAMKILDKQKVVKLKQVEHTLNEKRILQAI 101 Query: 466 QSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLYLH 645 Q P +V F N +Y+VLEY+ G + +++V EP+ Q++ YLH Sbjct: 102 QFPFLVSLRYHFKDNSNLYMVLEYVPGGEMFSHLRKVGRFSEPHSRFYAAQIVLAFEYLH 161 Query: 646 HERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISGSS 825 + +I+RD+KP NLL++ +G +K+TDFG + + G+ T GT Y+APE I Sbjct: 162 Y-LDLIYRDLKPENLLIDSQGYLKVTDFGFAKRVK---GRTWTLCGTPEYLAPEIILSKG 217 Query: 826 YDYKSDVWSLGLVILECAIGRFPY 897 Y+ D W+LG+++ E A G P+ Sbjct: 218 YNKAVDWWALGVLVYEMAAGYPPF 241
>P21137:KAPC_CAEEL cAMP-dependent protein kinase catalytic subunit - Caenorhabditis| elegans Length = 404 Score = 120 bits (300), Expect = 2e-26 Identities = 84/268 (31%), Positives = 135/268 (50%), Gaps = 8/268 (2%) Frame = +1 Query: 295 MDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGI--QMNIQESVRKQIVQELKINQATQ 468 +DD + I+ +G GS G V LV+HK G +YA+K + Q ++ + + E +I QA Sbjct: 78 LDDFDRIKTLGTGSFGRVMLVKHKQSGNYYAMKILDKQKVVKLKQVEHTLNEKRILQAID 137 Query: 469 SPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLYLHH 648 P +V SF N +Y+VLE++ G + ++++ EP+ Q++ YLH Sbjct: 138 FPFLVNMTFSFKDNSNLYMVLEFISGGEMFSHLRRIGRFSEPHSRFYAAQIVLAFEYLH- 196 Query: 649 ERHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISGSSY 828 +I+RD+KP NLL++ G +KITDFG + + G+ T GT Y+APE I Y Sbjct: 197 SLDLIYRDLKPENLLIDSTGYLKITDFGFAKRVK---GRTWTLCGTPEYLAPEIILSKGY 253 Query: 829 DYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYE-LLEAIVDQPPPSAPADQFSPEFC 1005 + D W+LG++I E A G Y P + + YE ++ V P FS E Sbjct: 254 NKAVDWWALGVLIYEMAAG---YPPFFADQPIQIYEKIVSGKVKFP------SHFSNELK 304 Query: 1006 SFISSCIQKDPAER-----KSASELLNH 1074 + + +Q D +R +++ NH Sbjct: 305 DLLKNLLQVDLTKRYGNLKNGVADIKNH 332
>Q5R4F3:TAOK3_PONPY Serine/threonine-protein kinase TAO3 - Pongo pygmaeus (Orangutan)| Length = 898 Score = 119 bits (299), Expect = 2e-26 Identities = 84/279 (30%), Positives = 145/279 (51%), Gaps = 6/279 (2%) Frame = +1 Query: 322 IGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRK--QIVQELKINQATQSPHIVLCHQ 495 IG GS G V + A+K + + +++ K I++E+K + + P+ + Sbjct: 30 IGHGSFGAVYFATNAHTNEVVAIKKMSYSGKQTHEKWQDILKEVKFLRQLKHPNTIEYKG 89 Query: 496 SFYHNGVIYLVLEYMDRGSLADIIK-QVKTILEPYLAVLCKQVLEGLLYLHHERHVIHRD 672 + +LV+EY GS +D+++ K + E +A + L GL YLH +IHRD Sbjct: 90 CYLKEHTAWLVMEYC-LGSASDLLEVHKKPLQEVEIAAITHGALHGLAYLHSHA-LIHRD 147 Query: 673 IKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERI---SGSSYDYKSD 843 IK N+L+ G+VK+ DFG ++V + + ++FVGT +MAPE I YD K D Sbjct: 148 IKAGNILLTEPGQVKLADFGSASVASPA----NSFVGTPYWMAPEVILAMDEGQYDGKVD 203 Query: 844 VWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAPADQFSPEFCSFISSC 1023 VWSLG+ +E A + ++ L I P+ +++++ F F+ C Sbjct: 204 VWSLGITCIELAERKPALFN------MNAMSALYHIAQNDSPTLQSNEWTDSFRRFVDYC 257 Query: 1024 IQKDPAERKSASELLNHAFIKKFEDKDLDLRILVESLEQ 1140 +QK P ER +++ELL H F++ +D LR+L++ +++ Sbjct: 258 LQKIPQERPTSAELLRHDFVR----RDRPLRVLIDLIQR 292
>Q6NU21:TAO1A_XENLA Serine/threonine-protein kinase TAO1-A - Xenopus laevis (African| clawed frog) Length = 1001 Score = 119 bits (299), Expect = 2e-26 Identities = 87/263 (33%), Positives = 138/263 (52%), Gaps = 6/263 (2%) Frame = +1 Query: 313 IQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRK--QIVQELKINQATQSPHIVL 486 ++ IG GS G V A+K + + ++S K IV+E+K Q + P+ + Sbjct: 31 LREIGHGSFGAVYFAHDASTREVVAIKKMSYSGKQSNEKWQDIVKEVKFLQRIKHPNSIE 90 Query: 487 CHQSFYHNGVIYLVLEYMDRGSLADIIK-QVKTILEPYLAVLCKQVLEGLLYLHHERHVI 663 + +LV+EY GS +D+++ K + E +A + L+GL YLH ++I Sbjct: 91 YKGCYLREHTAWLVMEYC-LGSASDLLEVHKKPLQEIEIAAITHGALQGLAYLH-SHNLI 148 Query: 664 HRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERI---SGSSYDY 834 HRDIK N+L+ G+VK+ DFG SA +AS ++FVGT +MAPE I YD Sbjct: 149 HRDIKAGNILLTEPGQVKLADFG-SASIAS---PANSFVGTPYWMAPEVILAMDEGQYDG 204 Query: 835 KSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAPADQFSPEFCSFI 1014 K DVWSLG+ +E A + P ++ L I P+ ++++S F +F+ Sbjct: 205 KVDVWSLGITCIELAERKPPLFN------MNAMSALYHIAQNESPTLQSNEWSDFFRNFV 258 Query: 1015 SSCIQKDPAERKSASELLNHAFI 1083 SC+QK P +R ++ ELL + F+ Sbjct: 259 DSCLQKIPQDRPTSDELLKNMFV 281
>Q9WVC6:SGK1_MOUSE Serine/threonine-protein kinase Sgk1 - Mus musculus (Mouse)| Length = 431 Score = 119 bits (299), Expect = 2e-26 Identities = 83/276 (30%), Positives = 133/276 (48%), Gaps = 7/276 (2%) Frame = +1 Query: 301 DLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMN--IQESVRKQIVQELKIN-QATQS 471 D ++VIGKGS G V L RHK FYA+K +Q +++ K I+ E + + + Sbjct: 97 DFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKH 156 Query: 472 PHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLYLHHE 651 P +V H SF +Y VL+Y++ G L +++ + LEP ++ L YLH Sbjct: 157 PFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLH-S 215 Query: 652 RHVIHRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERISGSSYD 831 ++++RD+KP N+L++ +G + +TDFG+ G TF GT Y+APE + YD Sbjct: 216 LNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNGTTSTFCGTPEYLAPEVLHKQPYD 275 Query: 832 YKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAPADQFSPEFCSF 1011 D W LG V+ E G P+ + E+ + I+++P P + Sbjct: 276 RTVDWWCLGAVLYEMLYGLPPFYS------RNTAEMYDNILNKPLQLKP--NITNSARHL 327 Query: 1012 ISSCIQKDPAERKSAS----ELLNHAFIKKFEDKDL 1107 + +QKD +R A E+ +H F DL Sbjct: 328 LEGLLQKDRTKRLGAKDDFMEIKSHIFFSLINWDDL 363
>Q6P3R8:NEK5_HUMAN Serine/threonine-protein kinase Nek5 - Homo sapiens (Human)| Length = 708 Score = 119 bits (299), Expect = 2e-26 Identities = 88/284 (30%), Positives = 144/284 (50%), Gaps = 6/284 (2%) Frame = +1 Query: 295 MDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGI---QMNIQESVRKQIVQELKINQAT 465 MD ++I+ IG+G+ G L + K +K I +M IQE + +E+ + + Sbjct: 1 MDKYDVIKAIGQGAFGKAYLAKGKSDSKHCVIKEINFEKMPIQEKEASK--KEVILLEKM 58 Query: 466 QSPHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTIL--EPYLAVLCKQVLEGLLY 639 + P+IV SF NG +++V+EY D G L I + + +L E + Q+ GL + Sbjct: 59 KHPNIVAFFNSFQENGRLFIVMEYCDGGDLMKRINRQRGVLFSEDQILGWFVQISLGLKH 118 Query: 640 LHHERHVIHRDIKPSNLLVNHKGEV-KITDFGVSAVLASSIGQRDTFVGTYNYMAPERIS 816 +H +R ++HRDIK N+ ++ G V K+ DFG++ VL +S+ T +GT Y++PE Sbjct: 119 IH-DRKILHRDIKAQNIFLSKNGMVAKLGDFGIARVLNNSMELARTCIGTPYYLSPEICQ 177 Query: 817 GSSYDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAPADQFSP 996 Y+ K+D+WSLG V+ E + P+ EG +L+ P +P FS Sbjct: 178 NKPYNNKTDIWSLGCVLYELCTLKHPF---EGNNLQQL--VLKICQAHFAPISPG--FSR 230 Query: 997 EFCSFISSCIQKDPAERKSASELLNHAFIKKFEDKDLDLRILVE 1128 E S IS Q P +R S + +L F++ K L ++ E Sbjct: 231 ELHSLISQLFQVSPRDRPSINSILKRPFLENLIPKYLTPEVIQE 274
>Q6DD27:TAOK3_XENLA Serine/threonine-protein kinase TAO3 - Xenopus laevis (African clawed| frog) Length = 896 Score = 119 bits (298), Expect = 3e-26 Identities = 84/279 (30%), Positives = 142/279 (50%), Gaps = 6/279 (2%) Frame = +1 Query: 322 IGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRK--QIVQELKINQATQSPHIVLCHQ 495 IG GS G V + A+K + + ++ K I++E+K Q + P+ + Sbjct: 30 IGHGSFGAVYFATNSTTNEIVAVKKMSYSGKQMNEKWQDIIKEVKFLQQLKHPNTIEYKG 89 Query: 496 SFYHNGVIYLVLEYMDRGSLADIIK-QVKTILEPYLAVLCKQVLEGLLYLHHERHVIHRD 672 + + +LV+EY GS +D+++ K + E +A + L+GL YLH ++IHRD Sbjct: 90 CYLKDHTAWLVMEYC-LGSASDLLEVHKKPLQEVEIAAITHGALQGLAYLH-SHNMIHRD 147 Query: 673 IKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERI---SGSSYDYKSD 843 IK N+L+ G+VK+ DFG AS ++FVGT +MAPE I YD K D Sbjct: 148 IKAGNILLTEPGQVKLADFG----SASKSSPANSFVGTPYWMAPEVILAMDEGQYDGKID 203 Query: 844 VWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAPADQFSPEFCSFISSC 1023 +WSLG+ +E A + P ++ L I P+ +++++ F F+ C Sbjct: 204 IWSLGITCIELAERKPPLFN------MNAMSALYHIAQNESPTLQSNEWTDSFKGFVDYC 257 Query: 1024 IQKDPAERKSASELLNHAFIKKFEDKDLDLRILVESLEQ 1140 +QK P ER ++ ELL H F+ ++ R+L++ +++ Sbjct: 258 LQKLPQERPASLELLRHDFVW----RERPARVLIDLIQR 292
>Q6GPK9:TAOK2_XENLA Serine/threonine-protein kinase TAO2 - Xenopus laevis (African clawed| frog) Length = 1025 Score = 119 bits (298), Expect = 3e-26 Identities = 83/265 (31%), Positives = 139/265 (52%), Gaps = 6/265 (2%) Frame = +1 Query: 313 IQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRK--QIVQELKINQATQSPHIVL 486 ++ IG GS G V R A+K + + ++S K I++E+K Q + P+ + Sbjct: 31 LREIGHGSFGAVYFARDIRNNEVVAIKKMSYSGKQSNEKWQDIIKEVKFLQKLRHPNTIE 90 Query: 487 CHQSFYHNGVIYLVLEYMDRGSLADIIK-QVKTILEPYLAVLCKQVLEGLLYLHHERHVI 663 + +LV+EY GS +D+++ K + E +A + L+GL YLH+ ++I Sbjct: 91 YKGCYLREHTAWLVMEYC-LGSASDLLEVHKKPLQEMEIAAITHGALQGLAYLHNH-NMI 148 Query: 664 HRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERI---SGSSYDY 834 HRD+K N+L+ G VK+ DFG ++++A + ++FVGT +MAPE I YD Sbjct: 149 HRDVKAGNILLTEPGLVKLGDFGSASIMAPA----NSFVGTPYWMAPEVILAMDEGQYDG 204 Query: 835 KSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAPADQFSPEFCSFI 1014 K DVWSLG+ +E A + P ++ L I P ++ +S F +F+ Sbjct: 205 KVDVWSLGITSIELAERKPPLFN------MNAMSALYHIAQNESPVLQSNHWSEYFRNFV 258 Query: 1015 SSCIQKDPAERKSASELLNHAFIKK 1089 SC+QK P +R ++ LL H F+++ Sbjct: 259 DSCLQKIPQDRPTSDMLLKHRFLQR 283
>Q7TSC3:NEK5_MOUSE Serine/threonine-protein kinase Nek5 - Mus musculus (Mouse)| Length = 627 Score = 119 bits (298), Expect = 3e-26 Identities = 80/268 (29%), Positives = 137/268 (51%), Gaps = 4/268 (1%) Frame = +1 Query: 295 MDDLEMIQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRKQIVQELKINQATQSP 474 MD+ +I++IG+G+ G V L + K + +K I + ++ K E+ + + P Sbjct: 1 MDNFHLIKIIGEGTFGKVYLAKDKSESSHCVIKEISLTKEKEASKN---EVILLARMEHP 57 Query: 475 HIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLC--KQVLEGLLYLHH 648 +IV SF NG +++V+EY D G L I++ + ++ +LC Q+ GL ++H Sbjct: 58 NIVTFFSSFQENGRLFIVMEYCDGGDLMQRIQRQRGVMFSEDQILCWFVQISLGLKHIH- 116 Query: 649 ERHVIHRDIKPSNLLVNHKGEV-KITDFGVSAVLASSIGQRDTFVGTYNYMAPERISGSS 825 +R ++HRDIK N+ ++ G V K+ DFG + L S+ T GT Y++PE Sbjct: 117 DRKILHRDIKSQNIFLSKNGMVAKLGDFGTARTLNDSMELAQTCAGTPYYLSPEICQNRP 176 Query: 826 YDYKSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYEL-LEAIVDQPPPSAPADQFSPEF 1002 Y+ K+D+WSLG V+ E + P+ +F+ L L+ + P +P FS + Sbjct: 177 YNNKTDIWSLGCVLYELCTLKHPFESN------NFHHLVLKICQGRVAPISP--HFSRDL 228 Query: 1003 CSFISSCIQKDPAERKSASELLNHAFIK 1086 S I + P +R S + LL F++ Sbjct: 229 QSLIPQLFRVSPQDRPSVTSLLKRPFLE 256
>Q9JLS3:TAOK2_RAT Serine/threonine-protein kinase TAO2 - Rattus norvegicus (Rat)| Length = 1235 Score = 119 bits (297), Expect = 4e-26 Identities = 82/263 (31%), Positives = 137/263 (52%), Gaps = 6/263 (2%) Frame = +1 Query: 313 IQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRK--QIVQELKINQATQSPHIVL 486 ++ IG GS G V R A+K + + ++S K I++E++ Q + P+ + Sbjct: 31 LREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPNTIQ 90 Query: 487 CHQSFYHNGVIYLVLEYMDRGSLADIIK-QVKTILEPYLAVLCKQVLEGLLYLHHERHVI 663 + +LV+EY GS +D+++ K + E +A + L+GL YLH ++I Sbjct: 91 YRGCYLREHTAWLVMEYC-LGSASDLLEVHKKPLQEVEIAAVTHGALQGLAYLH-SHNMI 148 Query: 664 HRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERI---SGSSYDY 834 HRD+K N+L++ G VK+ DFG ++++A + ++FVGT +MAPE I YD Sbjct: 149 HRDVKAGNILLSEPGLVKLGDFGSASIMAPA----NSFVGTPYWMAPEVILAMDEGQYDG 204 Query: 835 KSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAPADQFSPEFCSFI 1014 K DVWSLG+ +E A + P ++ L I P+ + +S F +F+ Sbjct: 205 KVDVWSLGITCIELAERKPPLFN------MNAMSALYHIAQNESPALQSGHWSEYFRNFV 258 Query: 1015 SSCIQKDPAERKSASELLNHAFI 1083 SC+QK P +R ++ LL H F+ Sbjct: 259 DSCLQKIPQDRPTSEVLLKHRFV 281
>Q6ZQ29:TAOK2_MOUSE Serine/threonine-protein kinase TAO2 - Mus musculus (Mouse)| Length = 1055 Score = 119 bits (297), Expect = 4e-26 Identities = 82/263 (31%), Positives = 137/263 (52%), Gaps = 6/263 (2%) Frame = +1 Query: 313 IQVIGKGSGGVVQLVRHKWVGTFYALKGIQMNIQESVRK--QIVQELKINQATQSPHIVL 486 ++ IG GS G V R A+K + + ++S K I++E++ Q + P+ + Sbjct: 31 LREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPNTIQ 90 Query: 487 CHQSFYHNGVIYLVLEYMDRGSLADIIK-QVKTILEPYLAVLCKQVLEGLLYLHHERHVI 663 + +LV+EY GS +D+++ K + E +A + L+GL YLH ++I Sbjct: 91 YRGCYLREHTAWLVMEYC-LGSASDLLEVHKKPLQEVEIAAVTHGALQGLAYLH-SHNMI 148 Query: 664 HRDIKPSNLLVNHKGEVKITDFGVSAVLASSIGQRDTFVGTYNYMAPERI---SGSSYDY 834 HRD+K N+L++ G VK+ DFG ++++A + ++FVGT +MAPE I YD Sbjct: 149 HRDVKAGNILLSEPGLVKLGDFGSASIMAPA----NSFVGTPYWMAPEVILAMDEGQYDG 204 Query: 835 KSDVWSLGLVILECAIGRFPYTPPEGEGWLSFYELLEAIVDQPPPSAPADQFSPEFCSFI 1014 K DVWSLG+ +E A + P ++ L I P+ + +S F +F+ Sbjct: 205 KVDVWSLGITCIELAERKPPLFN------MNAMSALYHIAQNESPALQSGHWSEYFRNFV 258 Query: 1015 SSCIQKDPAERKSASELLNHAFI 1083 SC+QK P +R ++ LL H F+ Sbjct: 259 DSCLQKIPQDRPTSEVLLKHRFV 281 Database: uniprot_sprot.fasta.out Posted date: Jul 19, 2007 5:58 PM Number of letters in database: 100,686,439 Number of sequences in database: 274,295 Lambda K H 0.318 0.134 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 274295 Number of Hits to DB: 235,647,350 Number of extensions: 5378967 Number of successful extensions: 22839 Number of sequences better than 10.0: 2620 Number of HSP's gapped: 18619 Number of HSP's successfully gapped: 2772 Length of query: 470 Length of database: 100,686,439 Length adjustment: 117 Effective length of query: 353 Effective length of database: 68,593,924 Effective search space: 24213655172 Effective search space used: 24213655172 Neighboring words threshold: 12 Window for multiple hits: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)
