>Q75HE6:MTHR_ORYSJ Probable methylenetetrahydrofolate reductase - Oryza sativa subsp.|
            japonica (Rice)
          Length = 594
 Score = 1127 bits (2915), Expect = 0.0
 Identities = 537/594 (90%), Positives = 573/594 (96%)
 Frame = +1

Query: 61   MKVIEKIQEAAANGRTVFSFEYFPPKTEEGFENLFERMDRMVAHGPNFCDITWGAGGSTA 240
            MKVIEKIQEAAA+GRTVFSFEYFPPKTEEG +NLFERMDRMVAHGPNFCDITWGAGGSTA
Sbjct: 1    MKVIEKIQEAAADGRTVFSFEYFPPKTEEGLDNLFERMDRMVAHGPNFCDITWGAGGSTA 60

Query: 241  DVTLDIANRMQNMVCVETMMHLTCTNMPVEKIDNALDTIKNNGIQNVLALRGDPPHGQDK 420
            D+TL+IANRMQNMVCVETMMHLTCTNMPVEKID+AL TIK+NGIQNVLALRGDPPHGQDK
Sbjct: 61   DLTLEIANRMQNMVCVETMMHLTCTNMPVEKIDDALTTIKSNGIQNVLALRGDPPHGQDK 120

Query: 421  FVQVAGGFSCALDLVQHIRAKYGDYFGITVAGYPEAHPEVILGEDGATEEAYSKDLAYLK 600
            FVQVAGGF+CALDLVQHIRAKYGDYFGITVAGYPEAHP+ I   +GAT EAYS DLAYLK
Sbjct: 121  FVQVAGGFACALDLVQHIRAKYGDYFGITVAGYPEAHPDAIQSTEGATPEAYSNDLAYLK 180

Query: 601  RKVDAGADVIVTQLFYDTDIFLKFVNDCRQIGITCPIVPGIMPINNYKGFVRMTGFCKTK 780
            +KVDAGAD+I+TQLFYDTDIFLKFVNDCRQIGITCPIVPGIMPINNYKGF+RMTGFCKTK
Sbjct: 181  QKVDAGADLIITQLFYDTDIFLKFVNDCRQIGITCPIVPGIMPINNYKGFLRMTGFCKTK 240

Query: 781  IPAEITAALDPIKDNEEAVKAYGIHLGTEMCKKILASGIKTLHLYTLNMEKTALAILMNL 960
            IPAEITAAL+PIKDNEEAVKAYGIHLGTEMCKKILA+GIKTLHLYTLNMEK+AL ILMNL
Sbjct: 241  IPAEITAALEPIKDNEEAVKAYGIHLGTEMCKKILATGIKTLHLYTLNMEKSALGILMNL 300

Query: 961  GLIEESKLSRTLPWRPPTNVFRVKEDVRPIFWANRPKSYISRTTGWDQYPQGRWGDSRNP 1140
            GLIEESK+SR+LPWRPPTNVFRVKEDVRPIFWANRPKSYISRT GWDQYP GRWGDSRNP
Sbjct: 301  GLIEESKISRSLPWRPPTNVFRVKEDVRPIFWANRPKSYISRTLGWDQYPHGRWGDSRNP 360

Query: 1141 SYGALNDHQFTRPRGRGKKLQEEWAVPLKSVQDINERFVNFCEGKLKSSPWSELDGLQPE 1320
            SYGAL D+QFTRPRGRGKKLQEEWAVP+KSV+DINERF+NFC+GKL SSPWSELDGLQPE
Sbjct: 361  SYGALTDYQFTRPRGRGKKLQEEWAVPVKSVEDINERFMNFCQGKLTSSPWSELDGLQPE 420

Query: 1321 TTIIDDQLVKMNSKGFLTINSQPAVNAEKSESPSVGWGGPGGYVYQKAYVEFFCAKEKLD 1500
            T IIDDQLVK+N KGFLTINSQPAVN E+S+S SVGWGGPGGYVYQKAY+EFFC+KEKLD
Sbjct: 421  TKIIDDQLVKINQKGFLTINSQPAVNGERSDSTSVGWGGPGGYVYQKAYLEFFCSKEKLD 480

Query: 1501 QLIEKSKAFPSLTYIAVNKEGESISNIPANAVNAVTWGVFPGKEIIQPTVVDSASFMVWK 1680
            QLIEKSKAFPSLTYIAVNK+GES SNIP NAVNAVTWGVFPGKEI+QPTVVDSASFMVWK
Sbjct: 481  QLIEKSKAFPSLTYIAVNKDGESFSNIPTNAVNAVTWGVFPGKEIVQPTVVDSASFMVWK 540

Query: 1681 DEAFEIWSRGWACLFPEGDSSRELLEQVQKTYCLVSLVDNDYISGDLFAAFKGI 1842
            DEAFEIWS+GWACLFPEGDSSRE+L++VQK+Y LVSLVDNDYI+GDLFAAFK I
Sbjct: 541  DEAFEIWSKGWACLFPEGDSSREILDKVQKSYFLVSLVDNDYINGDLFAAFKEI 594

>Q9SE94:MTHR1_MAIZE Methylenetetrahydrofolate reductase 1 - Zea mays (Maize)|
          Length = 593

 Score = 1107 bits (2864), Expect = 0.0
 Identities = 528/592 (89%), Positives = 560/592 (94%)
 Frame = +1

Query: 61   MKVIEKIQEAAANGRTVFSFEYFPPKTEEGFENLFERMDRMVAHGPNFCDITWGAGGSTA 240
            MKVIEKI EAA +GRT FSFEYFPPKTEEG ENLFERMDRMVAHGP+FCDITWGAGGSTA
Sbjct: 1    MKVIEKILEAAGDGRTAFSFEYFPPKTEEGVENLFERMDRMVAHGPSFCDITWGAGGSTA 60

Query: 241  DVTLDIANRMQNMVCVETMMHLTCTNMPVEKIDNALDTIKNNGIQNVLALRGDPPHGQDK 420
            D+TL+IANRMQNMVCVETMMHLTCTNMPVEKID+AL+TIK+NGIQNVLALRGDPPHGQDK
Sbjct: 61   DLTLEIANRMQNMVCVETMMHLTCTNMPVEKIDHALETIKSNGIQNVLALRGDPPHGQDK 120

Query: 421  FVQVAGGFSCALDLVQHIRAKYGDYFGITVAGYPEAHPEVILGEDGATEEAYSKDLAYLK 600
            FVQV GGF+CALDLVQHIRAKYGDYFGITVAGYPEAHP+ I GE GAT EAYS DLAYLK
Sbjct: 121  FVQVEGGFACALDLVQHIRAKYGDYFGITVAGYPEAHPDAIQGEGGATLEAYSNDLAYLK 180

Query: 601  RKVDAGADVIVTQLFYDTDIFLKFVNDCRQIGITCPIVPGIMPINNYKGFVRMTGFCKTK 780
            RKVDAGAD+IVTQLFYDTDIFLKFVNDCRQIGITCPIVPGIMPINNYKGF+RMTGFCKTK
Sbjct: 181  RKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGITCPIVPGIMPINNYKGFLRMTGFCKTK 240

Query: 781  IPAEITAALDPIKDNEEAVKAYGIHLGTEMCKKILASGIKTLHLYTLNMEKTALAILMNL 960
            IP+EITAALDPIKDNEEAV+ YGIHLGTEMCKKILA+GIKTLHLYTLNM+K+A+ ILMNL
Sbjct: 241  IPSEITAALDPIKDNEEAVRQYGIHLGTEMCKKILATGIKTLHLYTLNMDKSAIGILMNL 300

Query: 961  GLIEESKLSRTLPWRPPTNVFRVKEDVRPIFWANRPKSYISRTTGWDQYPQGRWGDSRNP 1140
            GLIEESK+SR LPWRP TNVFRVKEDVRPIFWANRPKSY+ RT GWDQYP GRWGDSRNP
Sbjct: 301  GLIEESKVSRPLPWRPATNVFRVKEDVRPIFWANRPKSYLKRTLGWDQYPHGRWGDSRNP 360

Query: 1141 SYGALNDHQFTRPRGRGKKLQEEWAVPLKSVQDINERFVNFCEGKLKSSPWSELDGLQPE 1320
            SYGAL DHQFTRPRGRGKKLQEEWAVPLKSV+DI+ERF NFC+GKL SSPWSELDGLQPE
Sbjct: 361  SYGALTDHQFTRPRGRGKKLQEEWAVPLKSVEDISERFTNFCQGKLTSSPWSELDGLQPE 420

Query: 1321 TTIIDDQLVKMNSKGFLTINSQPAVNAEKSESPSVGWGGPGGYVYQKAYVEFFCAKEKLD 1500
            T IIDDQLV +N KGFLTINSQPAVN EKS+SP+VGWGGPGGYVYQKAY+EFFCAKEKLD
Sbjct: 421  TKIIDDQLVNINQKGFLTINSQPAVNGEKSDSPTVGWGGPGGYVYQKAYLEFFCAKEKLD 480

Query: 1501 QLIEKSKAFPSLTYIAVNKEGESISNIPANAVNAVTWGVFPGKEIIQPTVVDSASFMVWK 1680
            QLIEK KAFPSLTYIAVNK+GE+ SNI  NAVNAVTWGVFPGKEIIQPTVVD ASFMVWK
Sbjct: 481  QLIEKIKAFPSLTYIAVNKDGETFSNISPNAVNAVTWGVFPGKEIIQPTVVDHASFMVWK 540

Query: 1681 DEAFEIWSRGWACLFPEGDSSRELLEQVQKTYCLVSLVDNDYISGDLFAAFK 1836
            DEAFEIW+RGW C+FPEGDSSRELLE+VQKTY LVSLVDNDY+ GDLFAAFK
Sbjct: 541  DEAFEIWTRGWGCMFPEGDSSRELLEKVQKTYYLVSLVDNDYVQGDLFAAFK 592

>O80585:MTHR2_ARATH Methylenetetrahydrofolate reductase 2 - Arabidopsis thaliana|
            (Mouse-ear cress)
          Length = 594

 Score =  989 bits (2558), Expect = 0.0
 Identities = 467/592 (78%), Positives = 533/592 (90%), Gaps = 1/592 (0%)
 Frame = +1

Query: 61   MKVIEKIQEAAANGRTVFSFEYFPPKTEEGFENLFERMDRMVAHGPNFCDITWGAGGSTA 240
            MKVI+KIQ  A  G+T FSFE+FPPKTE+G +NLFERMDRMVA+GP FCDITWGAGGSTA
Sbjct: 1    MKVIDKIQSLADEGKTAFSFEFFPPKTEDGVDNLFERMDRMVAYGPTFCDITWGAGGSTA 60

Query: 241  DVTLDIANRMQNMVCVETMMHLTCTNMPVEKIDNALDTIKNNGIQNVLALRGDPPHGQDK 420
            D+TLDIA+RMQN+VCVE+MMHLTCTNMPVEKID+AL+TI++NGIQNVLALRGDPPHGQDK
Sbjct: 61   DLTLDIASRMQNVVCVESMMHLTCTNMPVEKIDHALETIRSNGIQNVLALRGDPPHGQDK 120

Query: 421  FVQVAGGFSCALDLVQHIRAKYGDYFGITVAGYPEAHPEVILGEDG-ATEEAYSKDLAYL 597
            FVQV GGF CALDLV HIR+KYGDYFGITVAGYPEAHP+VI GE+G A+ EAY  DL YL
Sbjct: 121  FVQVEGGFDCALDLVNHIRSKYGDYFGITVAGYPEAHPDVI-GENGLASNEAYQSDLEYL 179

Query: 598  KRKVDAGADVIVTQLFYDTDIFLKFVNDCRQIGITCPIVPGIMPINNYKGFVRMTGFCKT 777
            K+K+DAGAD+IVTQLFYDTDIFLKFVNDCRQIGI+CPIVPGIMPINNY+GF+RMTGFCKT
Sbjct: 180  KKKIDAGADLIVTQLFYDTDIFLKFVNDCRQIGISCPIVPGIMPINNYRGFLRMTGFCKT 239

Query: 778  KIPAEITAALDPIKDNEEAVKAYGIHLGTEMCKKILASGIKTLHLYTLNMEKTALAILMN 957
            KIP E+ AAL+PIKDNEEAVKAYGIHLGTEMCKK+LA G+K+LHLYTLNMEK+ALAILMN
Sbjct: 240  KIPVEVMAALEPIKDNEEAVKAYGIHLGTEMCKKMLAHGVKSLHLYTLNMEKSALAILMN 299

Query: 958  LGLIEESKLSRTLPWRPPTNVFRVKEDVRPIFWANRPKSYISRTTGWDQYPQGRWGDSRN 1137
            LG+I+ESK+SR+LPWR P NVFR KEDVRPIFWANRPKSYISRT GW+ +PQGRWGDSR+
Sbjct: 300  LGMIDESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTKGWEDFPQGRWGDSRS 359

Query: 1138 PSYGALNDHQFTRPRGRGKKLQEEWAVPLKSVQDINERFVNFCEGKLKSSPWSELDGLQP 1317
             SYGAL+DHQF+RPR R KKLQ+EW VPLKSV+DI E+F   C G LKSSPWSELDGLQP
Sbjct: 360  ASYGALSDHQFSRPRARDKKLQQEWVVPLKSVEDIQEKFKELCLGNLKSSPWSELDGLQP 419

Query: 1318 ETTIIDDQLVKMNSKGFLTINSQPAVNAEKSESPSVGWGGPGGYVYQKAYVEFFCAKEKL 1497
            ET II++QL+K+NSKGFLTINSQP+VNAE+S+SP+VGWGGP GYVYQKAY+EFFC+KEKL
Sbjct: 420  ETRIINEQLIKVNSKGFLTINSQPSVNAERSDSPTVGWGGPVGYVYQKAYLEFFCSKEKL 479

Query: 1498 DQLIEKSKAFPSLTYIAVNKEGESISNIPANAVNAVTWGVFPGKEIIQPTVVDSASFMVW 1677
            D ++EK KA PS+TY+AVNK  + +SN     VNAVTWGVFP KEIIQPT+VD ASF VW
Sbjct: 480  DAVVEKCKALPSITYMAVNKGEQWVSNTAQADVNAVTWGVFPAKEIIQPTIVDPASFNVW 539

Query: 1678 KDEAFEIWSRGWACLFPEGDSSRELLEQVQKTYCLVSLVDNDYISGDLFAAF 1833
            KDEAFE WSR WA L+PE D SR LLE+V+ +Y LVSLV+NDYI+GD+FA F
Sbjct: 540  KDEAFETWSRSWANLYPEADPSRNLLEEVKNSYYLVSLVENDYINGDIFAVF 591

>Q9SE60:MTHR1_ARATH Methylenetetrahydrofolate reductase 1 - Arabidopsis thaliana|
            (Mouse-ear cress)
          Length = 592

 Score =  969 bits (2505), Expect = 0.0
 Identities = 448/591 (75%), Positives = 525/591 (88%)
 Frame = +1

Query: 61   MKVIEKIQEAAANGRTVFSFEYFPPKTEEGFENLFERMDRMVAHGPNFCDITWGAGGSTA 240
            MKV++KI+     G+T FSFE+FPPKTE+G ENLFERMDR+V++GP FCDITWGAGGSTA
Sbjct: 1    MKVVDKIKSVTEQGQTAFSFEFFPPKTEDGVENLFERMDRLVSYGPTFCDITWGAGGSTA 60

Query: 241  DVTLDIANRMQNMVCVETMMHLTCTNMPVEKIDNALDTIKNNGIQNVLALRGDPPHGQDK 420
            D+TL+IA+RMQN++CVETMMHLTCTNMP+EKID+AL+TI++NGIQNVLALRGDPPHGQDK
Sbjct: 61   DLTLEIASRMQNVICVETMMHLTCTNMPIEKIDHALETIRSNGIQNVLALRGDPPHGQDK 120

Query: 421  FVQVAGGFSCALDLVQHIRAKYGDYFGITVAGYPEAHPEVILGEDGATEEAYSKDLAYLK 600
            FVQV GGF+CALDLV HIR+KYGDYFGITVAGYPEAHP+VI  +  AT E+Y  DLAYLK
Sbjct: 121  FVQVEGGFACALDLVNHIRSKYGDYFGITVAGYPEAHPDVIEADGLATPESYQSDLAYLK 180

Query: 601  RKVDAGADVIVTQLFYDTDIFLKFVNDCRQIGITCPIVPGIMPINNYKGFVRMTGFCKTK 780
            +KVDAGAD+IVTQLFYDTDIFLKFVNDCRQIGI CPIVPGIMPI+NYKGF+RM GFCKTK
Sbjct: 181  KKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGINCPIVPGIMPISNYKGFLRMAGFCKTK 240

Query: 781  IPAEITAALDPIKDNEEAVKAYGIHLGTEMCKKILASGIKTLHLYTLNMEKTALAILMNL 960
            IPAE+TAAL+PIKDN+EAVKAYGIH  TEMCKKILA GI +LHLYTLN++K+A+ ILMNL
Sbjct: 241  IPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLYTLNVDKSAIGILMNL 300

Query: 961  GLIEESKLSRTLPWRPPTNVFRVKEDVRPIFWANRPKSYISRTTGWDQYPQGRWGDSRNP 1140
            GLI+ESK+SR+LPWR P NVFR KEDVRPIFWANRPKSYISRT GW+ +P GRWGDS + 
Sbjct: 301  GLIDESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTKGWNDFPHGRWGDSHSA 360

Query: 1141 SYGALNDHQFTRPRGRGKKLQEEWAVPLKSVQDINERFVNFCEGKLKSSPWSELDGLQPE 1320
            +Y  L+D+QF RP+GR KKLQ+EW VPLKS++D+ E+F   C G LKSSPWSELDGLQPE
Sbjct: 361  AYSTLSDYQFARPKGRDKKLQQEWVVPLKSIEDVQEKFKELCIGNLKSSPWSELDGLQPE 420

Query: 1321 TTIIDDQLVKMNSKGFLTINSQPAVNAEKSESPSVGWGGPGGYVYQKAYVEFFCAKEKLD 1500
            T II++QL K+NS GFLTINSQP+VNA KS+SP++GWGGPGGYVYQKAY+EFFC+K+KLD
Sbjct: 421  TKIINEQLGKINSNGFLTINSQPSVNAAKSDSPAIGWGGPGGYVYQKAYLEFFCSKDKLD 480

Query: 1501 QLIEKSKAFPSLTYIAVNKEGESISNIPANAVNAVTWGVFPGKEIIQPTVVDSASFMVWK 1680
             L+EKSKAFPS+TY+AVNK    +SN   + VNAVTWGVFP KE+IQPT+VD ASF VWK
Sbjct: 481  TLVEKSKAFPSITYMAVNKSENWVSNTGESDVNAVTWGVFPAKEVIQPTIVDPASFKVWK 540

Query: 1681 DEAFEIWSRGWACLFPEGDSSRELLEQVQKTYCLVSLVDNDYISGDLFAAF 1833
            DEAFEIWSR WA L+PE D SR+LLE+V+ +Y LVSLVDN+YI+GD+F+ F
Sbjct: 541  DEAFEIWSRSWANLYPEDDPSRKLLEEVKNSYYLVSLVDNNYINGDIFSVF 591

>P42898:MTHR_HUMAN Methylenetetrahydrofolate reductase - Homo sapiens (Human)|
          Length = 656

 Score =  512 bits (1319), Expect = e-144
 Identities = 263/600 (43%), Positives = 377/600 (62%), Gaps = 15/600 (2%)
 Frame = +1

Query: 52   QRKMKVIEKIQEAAANGRTVFSFEYFPPKTEEGFENLFERMDRMVAHGPNFCDITW---G 222
            +R  ++ EK++    +G   FS E+FPP+T EG  NL  R DRM A GP + D+TW   G
Sbjct: 40   ERHERLREKMRRRLESGDKWFSLEFFPPRTAEGAVNLISRFDRMAAGGPLYIDVTWHPAG 99

Query: 223  AGGSTADVT-LDIANRMQNMVCVETMMHLTCTNMPVEKIDNALDTIKNNGIQNVLALRGD 399
              GS  + + + IA+   N   +ET++H+TC    +E+I   L   K  G++N++ALRGD
Sbjct: 100  DPGSDKETSSMMIASTAVNYCGLETILHMTCCRQRLEEITGHLHKAKQLGLKNIMALRGD 159

Query: 400  PPHGQDKFVQVAGGFSCALDLVQHIRAKYGDYFGITVAGYPEAHPEVILGEDGATEEAYS 579
            P    D++ +  GGF+ A+DLV+HIR+++GDYF I VAGYP+ HPE           ++ 
Sbjct: 160  PIG--DQWEEEEGGFNYAVDLVKHIRSEFGDYFDICVAGYPKGHPEA---------GSFE 208

Query: 580  KDLAYLKRKVDAGADVIVTQLFYDTDIFLKFVNDCRQIGITCPIVPGIMPINNYKGFVRM 759
             DL +LK KV AGAD I+TQLF++ D F +FV  C  +GITCPIVPGI PI  Y    ++
Sbjct: 209  ADLKHLKEKVSAGADFIITQLFFEADTFFRFVKACTDMGITCPIVPGIFPIQGYHSLRQL 268

Query: 760  TGFCKTKIPAEITAALDPIKDNEEAVKAYGIHLGTEMCKKILASG-IKTLHLYTLNMEKT 936
                K ++P EI   ++PIKDN+ A++ YGI L   +C+++LASG +  LH YTLN E  
Sbjct: 269  VKLSKLEVPQEIKDVIEPIKDNDAAIRNYGIELAVSLCQELLASGLVPGLHFYTLNREMA 328

Query: 937  ALAILMNLGLIEESKLSRTLPWRPPTNVFRVKEDVRPIFWANRPKSYISRTTGWDQYPQG 1116
               +L  LG+  E    R LPW    +  R +EDVRPIFWA+RPKSYI RT  WD++P G
Sbjct: 329  TTEVLKRLGMWTEDP-RRPLPWALSAHPKRREEDVRPIFWASRPKSYIYRTQEWDEFPNG 387

Query: 1117 RWGDSRNPSYGALNDHQ--FTRPRGRGKKLQEEWAVPLKSVQDINERFVNFCEG------ 1272
            RWG+S +P++G L D+   + + +   ++L + W   L S + + E FV +  G      
Sbjct: 388  RWGNSSSPAFGELKDYYLFYLKSKSPKEELLKMWGEELTSEESVFEVFVLYLSGEPNRNG 447

Query: 1273 -KLKSSPWSELDGLQPETTIIDDQLVKMNSKGFLTINSQPAVNAEKSESPSVGWGGPGGY 1449
             K+   PW++ + L  ET+++ ++L+++N +G LTINSQP +N + S  P VGWG  GGY
Sbjct: 448  HKVTCLPWND-EPLAAETSLLKEELLRVNRQGILTINSQPNINGKPSSDPIVGWGPSGGY 506

Query: 1450 VYQKAYVEFFCAKEKLDQLIEKSKAFP-SLTYIAVNKEGESISNIPANAVNAVTWGVFPG 1626
            V+QKAY+EFF ++E  + L++  K +   + Y  VN +GE+I+N P    NAVTWG+FPG
Sbjct: 507  VFQKAYLEFFTSRETAEALLQVLKKYELRVNYHLVNVKGENITNAPELQPNAVTWGIFPG 566

Query: 1627 KEIIQPTVVDSASFMVWKDEAFEIWSRGWACLFPEGDSSRELLEQVQKTYCLVSLVDNDY 1806
            +EIIQPTVVD  SFM WKDEAF +W   W  L+ E   SR +++ +   Y LV+LVDND+
Sbjct: 567  REIIQPTVVDPVSFMFWKDEAFALWIERWGKLYEEESPSRTIIQYIHDNYFLVNLVDNDF 626

>Q60HE5:MTHR_MACFA Methylenetetrahydrofolate reductase - Macaca fascicularis (Crab|
            eating macaque) (Cynomolgus monkey)
          Length = 656

 Score =  507 bits (1305), Expect = e-143
 Identities = 262/600 (43%), Positives = 375/600 (62%), Gaps = 15/600 (2%)
 Frame = +1

Query: 52   QRKMKVIEKIQEAAANGRTVFSFEYFPPKTEEGFENLFERMDRMVAHGPNFCDITW---G 222
            +R  ++ +K++    +G   FS E+FPP+T EG  NL  R DRM A GP F D+TW   G
Sbjct: 40   ERHERLRDKMRRRMESGDKWFSLEFFPPRTAEGAVNLISRFDRMAAGGPLFIDVTWHPAG 99

Query: 223  AGGSTADVT-LDIANRMQNMVCVETMMHLTCTNMPVEKIDNALDTIKNNGIQNVLALRGD 399
              GS  + + + IA+   N   +ET++H+TC    +E+I   L   K  G++N++ALRGD
Sbjct: 100  DPGSDKETSSMMIASTAVNYCGLETILHMTCCCQRLEEITGHLHKAKQLGLKNIMALRGD 159

Query: 400  PPHGQDKFVQVAGGFSCALDLVQHIRAKYGDYFGITVAGYPEAHPEVILGEDGATEEAYS 579
            P    D++ +  GGF+ A+DLV+HIR+++GDYF + VAGYP+ HPE           ++ 
Sbjct: 160  PIG--DQWEEEEGGFNYAVDLVKHIRSEFGDYFDLCVAGYPKGHPEA---------GSFE 208

Query: 580  KDLAYLKRKVDAGADVIVTQLFYDTDIFLKFVNDCRQIGITCPIVPGIMPINNYKGFVRM 759
             DL +LK KV AGAD I+TQLF++ D F +FV  C  +GITCPIVPGI PI  Y    ++
Sbjct: 209  ADLKHLKEKVSAGADFIITQLFFEADTFFRFVKACTDMGITCPIVPGIFPIQGYHSLRQL 268

Query: 760  TGFCKTKIPAEITAALDPIKDNEEAVKAYGIHLGTEMCKKILASG-IKTLHLYTLNMEKT 936
                K ++P EI   ++PIKDN+ A++ YGI L   +C ++LASG +  LH YTLN E  
Sbjct: 269  VKQSKLEVPQEIKDVIEPIKDNDAAIRNYGIELAVSLCHELLASGLVPGLHFYTLNREMA 328

Query: 937  ALAILMNLGLIEESKLSRTLPWRPPTNVFRVKEDVRPIFWANRPKSYISRTTGWDQYPQG 1116
               +L  LG+  E    R LPW    +  R +EDVRPIFWA+RPKSYI RT  WD++P G
Sbjct: 329  TTEVLKRLGMWTEDP-RRPLPWALSAHPKRREEDVRPIFWASRPKSYIYRTQEWDEFPNG 387

Query: 1117 RWGDSRNPSYGALNDHQ--FTRPRGRGKKLQEEWAVPLKSVQDINERFVNFCEG------ 1272
            RWG+S +P++G L D+   + + +   + L + W   L S + + E FV +  G      
Sbjct: 388  RWGNSSSPAFGELKDYYLFYLKSKSPRELLLKMWGEELTSEESVFEVFVLYLSGEPNRNG 447

Query: 1273 -KLKSSPWSELDGLQPETTIIDDQLVKMNSKGFLTINSQPAVNAEKSESPSVGWGGPGGY 1449
             K+   PW++ + L  ET+++ ++L+++N +G LTINSQP +N + S  P VGWG  GGY
Sbjct: 448  HKVTCLPWND-EPLAAETSLLKEELLRVNRQGILTINSQPNINGKPSSDPVVGWGPSGGY 506

Query: 1450 VYQKAYVEFFCAKEKLDQLIEKSKAFP-SLTYIAVNKEGESISNIPANAVNAVTWGVFPG 1626
            V+QKAY+EFF ++E  + L++  K +   + Y  VN +GE+I+N P    NAVTWG+FPG
Sbjct: 507  VFQKAYLEFFTSRETAEALLQVLKKYELRVNYHLVNVKGENITNAPELQPNAVTWGIFPG 566

Query: 1627 KEIIQPTVVDSASFMVWKDEAFEIWSRGWACLFPEGDSSRELLEQVQKTYCLVSLVDNDY 1806
            +EIIQPTVVD  SFM WKDEAF +W   W  L+ E   SR +++ +   Y LV+LVDND+
Sbjct: 567  REIIQPTVVDPISFMFWKDEAFALWIEQWGKLYEEESPSRTIIQYIHDNYFLVNLVDNDF 626

>P53128:MTHR2_YEAST Methylenetetrahydrofolate reductase 2 - Saccharomyces cerevisiae|
            (Baker's yeast)
          Length = 600

 Score =  503 bits (1296), Expect = e-142
 Identities = 266/600 (44%), Positives = 376/600 (62%), Gaps = 14/600 (2%)
 Frame = +1

Query: 61   MKVIEKI-QEAAANGRTVFSFEYFPPKTEEGFENLFERMDRMV-AHGPNFCDITWGAGGS 234
            MK+ EK+ Q    +G+  +SFEYF PKT +G +NL++RMDRM  A  P F DITW AGG 
Sbjct: 1    MKITEKLEQHRQTSGKPTYSFEYFVPKTTQGVQNLYDRMDRMYEASLPQFIDITWNAGGG 60

Query: 235  T-ADVTLDIANRMQNMVCVETMMHLTCTNMPVEKIDNALDTIKNNGIQNVLALRGDPPHG 411
              + ++ D+    Q+++ +ET MHLTCTNMP+  ID+AL+   ++G QN+LALRGDPP  
Sbjct: 61   RLSHLSTDLVATAQSVLGLETCMHLTCTNMPISMIDDALENAYHSGCQNILALRGDPPRD 120

Query: 412  QDKFVQVAGGFSCALDLVQHIRAKYGDYFGITVAGYPEAHPEVILGEDGATEEAYSKDLA 591
             + +  V GGF  A DL+++I++KYGD+F I VAGYPE HPE+         +    DL 
Sbjct: 121  AENWTPVEGGFQYAKDLIKYIKSKYGDHFAIGVAGYPECHPEL-------PNKDVKLDLE 173

Query: 592  YLKRKVDAGADVIVTQLFYDTDIFLKFVNDCRQIGITCPIVPGIMPINNYKGFVRMTGFC 771
            YLK+K+DAG D I+TQ+FYD D F+ + +  R  G+  PI+PGIMPI  Y  F+R   + 
Sbjct: 174  YLKQKIDAGGDFIITQMFYDVDNFINWCSQVRAAGMDVPIIPGIMPITTYAAFLRRAQWG 233

Query: 772  KTKIPAEITAALDPIKDNEEAVKAYGIHLGTEMCKKILASG-IKTLHLYTLNMEKTALAI 948
            +  IP   ++ LDPIKD++E V+  G +L  EMC+K+L SG +  LH+YT+N+EK  L I
Sbjct: 234  QISIPQHFSSRLDPIKDDDELVRDIGTNLIVEMCQKLLDSGYVSHLHIYTMNLEKAPLMI 293

Query: 949  LMNLGLI-EESKLS----RTLPWRPPTNVFRVKEDVRPIFWANRPKSYISRTTGW--DQY 1107
            L  L ++  ES+ +      LPWR   N  R  E+VRPIFW  RP SY++RT+ W  D++
Sbjct: 294  LERLNILPTESEFNAHPLAVLPWRKSLNPKRKNEEVRPIFWKRRPYSYVARTSQWAVDEF 353

Query: 1108 PQGRWGDSRNPSYGALNDHQFTRPRGRGKKLQEEWAVPLKSVQDINERFVNFCEGKLKSS 1287
            P GR+GDS +P++G L+       R    K  E W+ P  S+ D+    +N+  G LK  
Sbjct: 354  PNGRFGDSSSPAFGDLDLCGSDLIRQSANKCLELWSTP-TSINDVAFLVINYLNGNLKCL 412

Query: 1288 PWSELDGLQPETTIIDDQLVKMNSKGFLTINSQPAVNAEKSESPSVGWGGPGGYVYQKAY 1467
            PWS++  +  E   I   L+++N    +TINSQP VN  +S     GWG   GYVYQK Y
Sbjct: 413  PWSDIP-INDEINPIKAHLIELNQHSIITINSQPQVNGIRSNDKIHGWGPKDGYVYQKQY 471

Query: 1468 VEFFCAKEKLDQLIEKSKAFPSLTYIAVNKEGESISNIPANA-VNAVTWGVFPGKEIIQP 1644
            +EF   K KL +LI+  K    LTY A++ +G+ +SN P N+  NAVTWG+FPG+EI+QP
Sbjct: 472  LEFMLPKTKLPKLIDTLKNNEFLTYFAIDSQGDLLSNHPDNSKSNAVTWGIFPGREILQP 531

Query: 1645 TVVDSASFMVWKDEAFEIWSRGWACLFPEGDS--SRELLEQVQKTYCLVSLVDNDYISGD 1818
            T+V+  SF+ WK+E + I +  W     + D   S + ++ +   YCLV++VDNDYIS D
Sbjct: 532  TIVEKISFLAWKEEFYHILNE-WKLNMNKYDKPHSAQFIQSLIDDYCLVNIVDNDYISPD 590

>Q5I598:MTHR_BOVIN Methylenetetrahydrofolate reductase - Bos taurus (Bovine)|
          Length = 655

 Score =  499 bits (1286), Expect = e-140
 Identities = 258/601 (42%), Positives = 380/601 (63%), Gaps = 16/601 (2%)
 Frame = +1

Query: 52   QRKMKVIEKIQEAAANGRTVFSFEYFPPKTEEGFENLFERMDRMVAHGPNFCDITW---G 222
            +R  ++ EK++    +G   FS E+FPP+T +G  NL  R DRM A GP F D+TW   G
Sbjct: 39   ERCERLREKMKRKMDSGDKWFSLEFFPPRTAQGAVNLISRFDRMGAGGPLFVDVTWHPAG 98

Query: 223  AGGSTADVT-LDIANRMQNMVCVETMMHLTCTNMPVEKIDNALDTIKNNGIQNVLALRGD 399
              GS  + + + IA+   N   +ET++H+TC +   E+I   L+  K  G++N+LALRGD
Sbjct: 99   DPGSDKETSSMVIASTAVNYCGLETILHMTCCHQSREEITGHLNKAKQLGLKNILALRGD 158

Query: 400  PPHGQDKFVQVAGGFSCALDLVQHIRAKYGDYFGITVAGYPEAHPEVILGEDGATEEAYS 579
            P    D++ +  GGF+ A DLV+HIR ++GDYF + VAGYP+ HPE          E++ 
Sbjct: 159  PIG--DQWEEEEGGFNYATDLVKHIRNEFGDYFDVCVAGYPKGHPE---------GESFE 207

Query: 580  KDLAYLKRKVDAGADVIVTQLFYDTDIFLKFVNDCRQIGITCPIVPGIMPINNYKGFVRM 759
             DL +LK KV AGAD I+TQLF++ + F +FV  C +IGITCP++PGI PI  Y    ++
Sbjct: 208  ADLKHLKEKVAAGADFIITQLFFEAETFFRFVKACSEIGITCPVLPGIFPIQGYHSLRQL 267

Query: 760  TGFCKTKIPAEITAALDPIKDNEEAVKAYGIHLGTEMCKKILASG-IKTLHLYTLNMEKT 936
                K ++P +I   ++PIKDN+ A++ YGI     +C+++LASG +  LH YTLN E  
Sbjct: 268  VKLSKLEVPQQIKDVIEPIKDNDAAIRNYGIEQAVSLCQELLASGLVPGLHFYTLNREVA 327

Query: 937  ALAILMNLGL-IEESKLSRTLPWRPPTNVFRVKEDVRPIFWANRPKSYISRTTGWDQYPQ 1113
             + +L  LGL IE+ +  R LPW    +  R  EDVRPIFWA+RPKSYI RT  WD++P 
Sbjct: 328  TIEVLKRLGLWIEDPR--RPLPWALSAHPKRRVEDVRPIFWASRPKSYIYRTQEWDEFPN 385

Query: 1114 GRWGDSRNPSYGALNDHQ--FTRPRGRGKKLQEEWAVPLKSVQDINERFVNFCEG----- 1272
            GRWG+S +P++G L D+   + + +   ++L + W   L S + + + F +   G     
Sbjct: 386  GRWGNSSSPAFGELKDYYLFYLKSKSPKEELLKMWGEELTSEESVFQVFAHHLSGEPNQN 445

Query: 1273 --KLKSSPWSELDGLQPETTIIDDQLVKMNSKGFLTINSQPAVNAEKSESPSVGWGGPGG 1446
              K+   PW++ + L  ET+++ ++L+++N +G LTINSQP +N + S  P VGWG  GG
Sbjct: 446  GYKVTCLPWND-EPLAAETSLMKEELLRVNRRGILTINSQPNINGKPSSDPIVGWGPSGG 504

Query: 1447 YVYQKAYVEFFCAKEKLDQLIEKSKAFP-SLTYIAVNKEGESISNIPANAVNAVTWGVFP 1623
            YV+QKAY+EFF ++E ++ L++  K +   + Y  V+ +GE+I+N P    NAVTWG+FP
Sbjct: 505  YVFQKAYLEFFTSRETVEALLQVLKKYELRVNYHIVDVKGENITNAPELQPNAVTWGIFP 564

Query: 1624 GKEIIQPTVVDSASFMVWKDEAFEIWSRGWACLFPEGDSSRELLEQVQKTYCLVSLVDND 1803
            G+EIIQPTVVD  SFM WKDEAF +W   W  L+ E   SR +++ +   Y LV+LVDN+
Sbjct: 565  GREIIQPTVVDPVSFMFWKDEAFALWIEQWGKLYEEESPSRMIIQYIHDNYFLVNLVDNE 624

Query: 1804 Y 1806
            +
Sbjct: 625  F 625

>Q9WU20:MTHR_MOUSE Methylenetetrahydrofolate reductase - Mus musculus (Mouse)|
          Length = 654

 Score =  498 bits (1282), Expect = e-140
 Identities = 257/600 (42%), Positives = 371/600 (61%), Gaps = 15/600 (2%)
 Frame = +1

Query: 52   QRKMKVIEKIQEAAANGRTVFSFEYFPPKTEEGFENLFERMDRMVAHGPNFCDITW---G 222
            +R  ++ EK++    +G   FS E+FPP+T EG  NL  R DRM A GP F D+TW   G
Sbjct: 39   ERHERLREKMRRRMDSGDKWFSLEFFPPRTAEGAVNLISRFDRMAAGGPLFVDVTWHPAG 98

Query: 223  AGGSTADVT-LDIANRMQNMVCVETMMHLTCTNMPVEKIDNALDTIKNNGIQNVLALRGD 399
              GS  + + + IA+   N   +ET++H+TC     E+I   L   K  G++N++ALRGD
Sbjct: 99   DPGSDKETSSMMIASTAVNYCGLETILHMTCCQQRPEEITGHLHRAKQLGLKNIMALRGD 158

Query: 400  PPHGQDKFVQVAGGFSCALDLVQHIRAKYGDYFGITVAGYPEAHPEVILGEDGATEEAYS 579
            P    D +    GGFS A DLV+HIR ++ DYF I VAGYP  HP+          E++ 
Sbjct: 159  PVG--DHWEAEEGGFSYATDLVKHIRTEFADYFDICVAGYPRGHPDA---------ESFE 207

Query: 580  KDLAYLKRKVDAGADVIVTQLFYDTDIFLKFVNDCRQIGITCPIVPGIMPINNYKGFVRM 759
             DL +LK KV AGAD I+TQLF++   F  FV  C +IGI+CPI+PGI PI  Y    ++
Sbjct: 208  DDLKHLKEKVSAGADFIITQLFFEASTFFSFVKACTEIGISCPILPGIFPIQGYTSLRQL 267

Query: 760  TGFCKTKIPAEITAALDPIKDNEEAVKAYGIHLGTEMCKKILASG-IKTLHLYTLNMEKT 936
                K ++P +I   ++PIKDN+ A++ YGI L   +C+++L SG +  LH YTLN E  
Sbjct: 268  VKLSKLEVPQKIKDVIEPIKDNDAAIRNYGIELAVRLCRELLDSGLVPGLHFYTLNREVA 327

Query: 937  ALAILMNLGLIEESKLSRTLPWRPPTNVFRVKEDVRPIFWANRPKSYISRTTGWDQYPQG 1116
             + +L  LG+  E    R LPW    +  R +EDVRPIFWA+RPKSYI RT  WD++P G
Sbjct: 328  TMEVLKQLGMWTEDP-RRPLPWALSAHPKRREEDVRPIFWASRPKSYIYRTQDWDEFPNG 386

Query: 1117 RWGDSRNPSYGALNDHQ--FTRPRGRGKKLQEEWAVPLKSVQDINERFVNFCEG------ 1272
            RWG+S +P++G L D+   + + +   ++L + W   L S + + E F ++  G      
Sbjct: 387  RWGNSSSPAFGELKDYYLFYLKSKSPREELLKMWGEELTSEESVFEVFEHYLSGEPNRHG 446

Query: 1273 -KLKSSPWSELDGLQPETTIIDDQLVKMNSKGFLTINSQPAVNAEKSESPSVGWGGPGGY 1449
             ++   PW++ + L  ET+++ ++L+++N  G LTINSQP +NA+ S  P VGWG  GGY
Sbjct: 447  YRVTCLPWND-EPLAAETSLMKEELLRVNRLGILTINSQPNINAKPSSDPVVGWGPSGGY 505

Query: 1450 VYQKAYVEFFCAKEKLDQLIEKSKAFP-SLTYIAVNKEGESISNIPANAVNAVTWGVFPG 1626
            V+QKAY+EFF ++E ++ L++  K +   + Y  V+ +GE+I+N P    NAVTWG+FPG
Sbjct: 506  VFQKAYLEFFTSRETVEALLQVLKTYELRVNYHIVDVKGENITNAPELQPNAVTWGIFPG 565

Query: 1627 KEIIQPTVVDSASFMVWKDEAFEIWSRGWACLFPEGDSSRELLEQVQKTYCLVSLVDNDY 1806
            +EIIQPTVVD  SFM WKDEAF +W   W  L+ E   SR +++ +   Y LV+LVDN++
Sbjct: 566  REIIQPTVVDPISFMFWKDEAFALWIEQWGKLYEEESPSRMIIQYIHDNYFLVNLVDNEF 625

>Q10258:MTHR1_SCHPO Methylenetetrahydrofolate reductase 1 - Schizosaccharomyces pombe|
            (Fission yeast)
          Length = 603

 Score =  491 bits (1263), Expect = e-138
 Identities = 266/602 (44%), Positives = 359/602 (59%), Gaps = 11/602 (1%)
 Frame = +1

Query: 61   MKVIEKIQEAAANGRTVFSFEYFPPKTEEGFENLFERMDRMVAHG-PNFCDITWGAGGST 237
            MK+ +K+       +  +S+E+FPPKT  G +NL+ R+DRM   G P F D+TWGAGG++
Sbjct: 1    MKISDKLLHPDWKEKVTYSYEFFPPKTSTGVQNLYNRIDRMKTWGRPMFVDVTWGAGGTS 60

Query: 238  ADVTLDIANRMQNMVCVETMMHLTCTNMPVEKIDNALDTIKNNGIQNVLALRGDPPHGQD 417
            +++T  I N +Q    V+T MHLTCTNM  E ID AL      G +N+LALRGDP    D
Sbjct: 61   SELTPGIVNVIQTDFEVDTCMHLTCTNMSTEMIDAALKRAHETGCRNILALRGDPVKDTD 120

Query: 418  KFVQVAGGFSCALDLVQHIRAKYGDYFGITVAGYPEAHPEVILGEDGATEEAYSKDLAYL 597
             + +   GF  A DLV++IR  Y D F I VAGYPE +         + ++   + + +L
Sbjct: 121  -WTEGESGFRYASDLVRYIRTHYNDEFCIGVAGYPEGY---------SPDDDIDESIKHL 170

Query: 598  KRKVDAGADVIVTQLFYDTDIFLKFVNDCRQIGITCPIVPGIMPINNYKGFVRMTGFCKT 777
            K KVD GAD IVTQ+FYD D F+ +V+  R  GI  PI PGIMPI  +  F+R   +   
Sbjct: 171  KLKVDEGADFIVTQMFYDVDNFIAWVDKVRAAGINIPIFPGIMPIQAWDSFIRRAKWSGV 230

Query: 778  KIPAEITAALDPIKDNEEAVKAYGIHLGTEMCKKILASGIKTLHLYTLNMEKTALAILMN 957
            KIP      L P+KD++E V+  G+ L  EMC+K++ASGI  LH YT+N+EK    I+  
Sbjct: 231  KIPQHFMDTLVPVKDDDEGVRERGVELIVEMCRKLIASGITRLHFYTMNLEKAVKMIIER 290

Query: 958  LGLIEESKLSRTLPWRPPTNVF---------RVKEDVRPIFWANRPKSYISRTTGWDQYP 1110
            LGL++E+      P     NV          R+ E VRPIFW  R +SY+SRT  WD+ P
Sbjct: 291  LGLLDEN----LAPIVDTNNVELTNASSQDRRINEGVRPIFWRTRNESYVSRTDQWDELP 346

Query: 1111 QGRWGDSRNPSYGALNDHQFTRPRGRGKKLQEEWAVPLKSVQDINERFVNFCEGKLKSSP 1290
             GRWGDSR+P++G  +  ++   R   K++   W  P KS  +I + F  +CE K+ S P
Sbjct: 347  HGRWGDSRSPAFGEFDAIRYGL-RMSPKEITTSWGSP-KSYSEIGDLFARYCEKKISSLP 404

Query: 1291 WSELDGLQPETTIIDDQLVKMNSKGFLTINSQPAVNAEKSESPSVGWGGPGGYVYQKAYV 1470
            WS+L  +  E  +I DQL+ MN   FLTINSQPA+N EKS  P  GWG P GYV+QK YV
Sbjct: 405  WSDLP-ISDEADLIRDQLLSMNRNAFLTINSQPALNGEKSSHPVFGWGPPNGYVFQKPYV 463

Query: 1471 EFFCAKEKLDQLIEKSKAFPSLTYIAVNKEGESISNIPANAVNAVTWGVFPGKEIIQPTV 1650
            EFF     L++L E  K   S++Y   NK G+  +N      NAVTWGVFP +EIIQPT+
Sbjct: 464  EFFVHPSLLNELKETVKKLNSVSYFVTNKNGDLDTNSQYEIPNAVTWGVFPNREIIQPTI 523

Query: 1651 VDSASFMVWKDEAFEIWSRGWACLFPEGDSSRELLEQVQKTYCLVSLVDNDYISG-DLFA 1827
            V+S SF+ WKDEA+ +    WA  +     SR+LL  + K + L  +VDND+ +G  LF 
Sbjct: 524  VESTSFLAWKDEAYSL-GMEWANAYSPDSISRKLLVSMMKEWFLCVIVDNDFQNGQSLFD 582

Query: 1828 AF 1833
             F
Sbjct: 583  VF 584

>Q17693:MTHR_CAEEL Probable methylenetetrahydrofolate reductase - Caenorhabditis elegans|
          Length = 663

 Score =  433 bits (1113), Expect = e-120
 Identities = 243/599 (40%), Positives = 354/599 (59%), Gaps = 21/599 (3%)
 Frame = +1

Query: 73   EKIQEAAANGRTVFSFEYFPPKTEEGFENLFERMDRMVAHGPNFCDITWGAGGSTADV-- 246
            E+I+      +  FS E+FPP+   G  N  ER++R+   G  F D+TW  G   A+V  
Sbjct: 60   ERIERLIDEKQQFFSLEFFPPRFVNGVPNFLERVERLSEGGSVFVDMTWHMGSDPANVDK 119

Query: 247  ---TLDIANRMQNMVCVETMMHLTCTNMPVEKIDNALDTIKNNGIQNVLALRGDPPHGQD 417
               +  IA  M +   V+TM+H+TC           L+  K  G++++LALRGD P G +
Sbjct: 120  VTSSSSIAASMLDYCGVDTMLHMTCVQYNKADTLKHLEQAKAMGLRSILALRGDLPPGTE 179

Query: 418  KFVQVAGGFSCALDLVQHIRAKYGDYFGITVAGYPEAHPEVILGEDGATEEAYSKDLAYL 597
              ++    F  ALD+++ IR +YG+YF I  AGYP  HP+           +Y  DL YL
Sbjct: 180  --LEDTHQFR-ALDMIRWIREEYGNYFSIGCAGYPLGHPQA---------PSYKADLMYL 227

Query: 598  KRKVDAGADVIVTQLFYDTDIFLKFVNDCRQIGITCPIVPGIMPINNYKGFVRMTGFCKT 777
            K K DAGA+ ++TQLF++ + F KFV DCR+IGIT PI+PGIMPI  Y+   R+    + 
Sbjct: 228  KAKCDAGANFVITQLFFEAETFEKFVRDCREIGITQPIIPGIMPIMGYESIKRIAKLSQL 287

Query: 778  KIPAEITAALDPIKDNEEAVKAYGIHLGTEMCKKILASG-IKTLHLYTLNMEKTALAILM 954
            +IP  I   L+PIK +++AV+ YG     EMC+++L +G   ++HLYT+N E +   IL 
Sbjct: 288  EIPQHILDDLEPIKHDDDAVQKYGTERCIEMCRRLLDNGTAPSIHLYTMNREGSIREILK 347

Query: 955  NLGLIEESKLSRTLPWRPPT-NVFRVKEDVRPIFWANRPKSYISRTTGWDQYPQGRWGDS 1131
            +LGL  + +  R  PW+  + +  R  E VRPI+W+ RP+SYI+RT  WDQ+P GRWG+S
Sbjct: 348  SLGL-WKLEGDRVFPWKNRSQHPIRCLESVRPIYWSFRPRSYITRTRDWDQFPNGRWGNS 406

Query: 1132 RNPSYGALNDH---QFTRPRGRGKKLQEEWAVPLKSVQDINERFVNF------CEG-KLK 1281
             +P++G ++ +     T  R    +L   +   ++S +D+   F+N+       +G K+ 
Sbjct: 407  SSPAFGDVSSYYLSNLTTVRNADDRL-AMFGANIESFEDVKRVFINYITQAPNADGVKVT 465

Query: 1282 SSPWSELD-GLQPETTIIDDQLVKMNSKGFLTINSQPAVNAEKSESPSVGWGGPGGYVYQ 1458
              PW+E + G+QPET++I +QLV  N  G LT+NSQP+VN   S  P VGWG PGGY YQ
Sbjct: 466  VLPWTEAETGVQPETSLISEQLVWCNENGILTVNSQPSVNGAPSTDPLVGWGKPGGYCYQ 525

Query: 1459 KAYVEFFCAKEKLDQLIE-KSKAFP-SLTYIAVNKEGE-SISNIPANAVNAVTWGVFPGK 1629
            KAY+E F   E  D+LI+   + FP  + Y A+NK+     +N       AVTWGVFPG 
Sbjct: 526  KAYLECFMTAELSDKLIQIIEREFPVRVNYHAINKDSTFDKTNSEETTPIAVTWGVFPGS 585

Query: 1630 EIIQPTVVDSASFMVWKDEAFEIWSRGWACLFPEGDSSRELLEQVQKTYCLVSLVDNDY 1806
            EI QPTVVD  SF  W+DEA+++W   W   +P+   S  +++ V   + LV+LVDND+
Sbjct: 586  EIAQPTVVDPLSFRAWRDEAYQMWMAQWGDFYPKESKSYGVIKAVHDEFRLVTLVDNDF 644

>O74927:MTHR2_SCHPO Methylenetetrahydrofolate reductase 2 - Schizosaccharomyces pombe|
            (Fission yeast)
          Length = 641

 Score =  375 bits (964), Expect = e-103
 Identities = 228/638 (35%), Positives = 332/638 (52%), Gaps = 55/638 (8%)
 Frame = +1

Query: 61   MKVIEKIQEAAANGRTVFSFEYFPPKTEEGFENLFERMDRMVAHG-PNFCDITWGAGGST 237
            MK+++ I +   NG   +SFEYFPPKT  G ENL  R+ RM  +  P F  +TWG  GST
Sbjct: 1    MKIVDLIDKIP-NGNAFYSFEYFPPKTTVGLENLSSRITRMSRNMMPLFSSVTWGTAGST 59

Query: 238  ADVTLDIANRMQNMVCVETMMHLTCTNMPVEKIDNALDTIKNNGIQNVLALRGDPPHGQD 417
            A+V++ +A  ++    +   +HLTCTN+    ID AL+T K  GI+N+LALRGDPP   D
Sbjct: 60   AEVSIYLAKMLEQHHKIPACLHLTCTNVDKAIIDKALETAKEYGIRNILALRGDPPLNSD 119

Query: 418  KFVQVAGGFSCALDLVQHIRAKYGDYFGITVAGYPEAHPEVILGEDGATEEAYSKDLAYL 597
             +      F  A+DLV++IR KYGDYF I VA YPE H +  + E     +   +D+ +L
Sbjct: 120  HWEGKVSEFEHAVDLVRYIREKYGDYFCIGVAAYPEGHVDSNVPE---LSKDPLRDIPFL 176

Query: 598  KRKVDAGADVIVTQLFYDTDIFLKFVNDCRQIGITC----PIVPGIMPINNYKGFVRMTG 765
              KV+AGAD I+TQ+FY+ + F+KF N  R          PI+P IMPI +Y    RMT 
Sbjct: 177  IEKVEAGADFIITQIFYEPEAFIKFENFVRNHSSNALRNIPIIPAIMPIQSYGSLKRMTR 236

Query: 766  FCKTKIPAEITAALDPIKDNEEAVKAYGIHLGTEMCKKIL---ASGIKTLHLYTLNMEKT 936
             C   +P+ +   L+  K ++EA+K  G+    +M KKI+      +   H  TLN+E++
Sbjct: 237  LCGCSVPSSLMQRLNAAKPDDEAIKNIGVEHIVDMIKKIMDNVQGRVHGFHFCTLNLERS 296

Query: 937  ALAILMNLGLI-----------EESKLSRT------------------LPWRPP-----T 1014
               IL N GL+           E+ KL RT                  +P + P     +
Sbjct: 297  VALILKNSGLLTKRWKQVESEMEDEKLLRTTRKRLSLDEPAELHNQVVVPSQQPVADKSS 356

Query: 1015 NVFRVKED-----------VRPIFWANRPKSYISRTTGWDQYPQGRWGDSRNPSYGALND 1161
            N+F   +                F  +     + R   WD +  GR+GD R+P+YG ++ 
Sbjct: 357  NLFVTSKQSSVSGHKDNLTEEAPFSVSEGSGVLGRQANWDDFTNGRFGDPRSPAYGEIDG 416

Query: 1162 HQFTR--PRGRGKKLQEEWAVPLKSVQDINERFVNFCEGKLKSSPWSELDGLQPETTIID 1335
            +  T   P     KL   W  P+    DI   F       + + PW + + ++ ET  I 
Sbjct: 417  YGPTLHFPPSEALKL---WGYPVDE-SDITSLFQKHIMSDISAIPWID-EPVEVETKTIA 471

Query: 1336 DQLVKMNSKGFLTINSQPAVNAEKSESPSVGWGGPGGYVYQKAYVEFFCAKEKLDQLIEK 1515
              L+K+N   + T+ SQPAVN   S  P  GWG  GG V+QKA+VE F   + L   I K
Sbjct: 472  KYLLKLNGNSWWTVGSQPAVNGAPSADPVFGWGPKGGRVFQKAFVECFVNGKDLKDFITK 531

Query: 1516 SKAFPSLTYIAVNKEGESISNIPANAVNAVTWGVFPGKEIIQPTVVDSASFMVWKDEAFE 1695
                P +TY A N + E ++N P +  +AVTWGV+PG+EIIQ T++   SF  W  E+F+
Sbjct: 532  WHDNPQVTYYAGNNKSEFLTNAPKDGASAVTWGVYPGREIIQSTIIAEVSFKAWLSESFQ 591

Query: 1696 IWSRGWACLFPEGDSSRELLEQVQKTYCLVSLVDNDYI 1809
            +W   WA L+ +   SR+LLE       LV+++ +D++
Sbjct: 592  VWGE-WANLYSKNTPSRKLLENCINDRWLVTVIHHDFM 628

>P46151:MTHR1_YEAST Methylenetetrahydrofolate reductase 1 - Saccharomyces cerevisiae|
           (Baker's yeast)
          Length = 657

 Score =  226 bits (575), Expect = 4e-58
 Identities = 132/293 (45%), Positives = 172/293 (58%), Gaps = 7/293 (2%)
 Frame = +1

Query: 94  ANGRTVFSFEYFPPKTEEGFENLFERMDRMVAHGPNFCDITWGAGGSTADVTLDIANRMQ 273
           A      S E+FPPKTE G  NL ERM RM A  P F  +TWGAGG+TA+ TL +A+  Q
Sbjct: 9   ARASPFISLEFFPPKTELGTRNLMERMHRMTALDPLFITVTWGAGGTTAEKTLTLASLAQ 68

Query: 274 NMVCVETMMHLTCTNMPVEKIDNALDTIKNNGIQNVLALRGDPPHGQDKFVQVA--GGFS 447
             + +   MHLTCTN     ID+ALD   N GI+N+LALRGDPP G+D     +    F 
Sbjct: 69  QTLNIPVCMHLTCTNTEKAIIDDALDRCYNAGIRNILALRGDPPIGEDWLDSQSNESPFK 128

Query: 448 CALDLVQHIRAKYGDYFGITVAGYPEAHPEVILGEDGATEEAYSKDLAYLKRKVDAGADV 627
            A+DLV++I+  YGD F + VA YPE H E   GE    E+   KDL YLK KV+AGAD 
Sbjct: 129 YAVDLVRYIKQSYGDKFCVGVAAYPEGHCE---GEAEGHEQDPLKDLVYLKEKVEAGADF 185

Query: 628 IVTQLFYDTDIFLKFVNDCRQ-IGITCPIVPGIMPINNYKGFVRMTGFCKTKIPAEITAA 804
           ++TQLFYD + FL F    R+ I    P+ PG+MPIN+Y  F R        IP  I + 
Sbjct: 186 VITQLFYDVEKFLTFEMLFRERISQDLPLFPGLMPINSYLLFHRAAKLSHASIPPAILSR 245

Query: 805 LDP-IKDNEEAVKAYGIHLGTEMCKKI---LASGIKTLHLYTLNMEKTALAIL 951
             P I+ ++ AVK+ G+ +  E+ ++I    +  IK  H YTLN+EK    I+
Sbjct: 246 FPPEIQSDDNAVKSIGVDILIELIQEIYQRTSGRIKGFHFYTLNLEKAIAQIV 298



 Score =  189 bits (479), Expect = 5e-47
 Identities = 95/250 (38%), Positives = 148/250 (59%), Gaps = 3/250 (1%)
 Frame = +1

Query: 1078 ISRTTGWDQYPQGRWGDSRNPSYGALNDHQFTRPRGRGKKLQEEWAVPLKSVQDINERFV 1257
            + R   WD++P GR+GDSR+P+YG ++ +  +    + K L E W +P K++ D+ + F+
Sbjct: 402  LGRDATWDEFPNGRFGDSRSPAYGEIDGYGPSIKVSKSKAL-ELWGIP-KTIGDLKDIFI 459

Query: 1258 NFCEGKLKSSPWSELDGLQPETTIIDDQLVKMNSKGFLTINSQPAVNAEKSESPSVGWGG 1437
             + EG   + PWS+L GL  ET +I ++L+++N +G+LT+ SQPA NA  S     GWG 
Sbjct: 460  KYLEGSTDAIPWSDL-GLSAETALIQEELIQLNYRGYLTLASQPATNATLSSDKIFGWGP 518

Query: 1438 PGGYVYQKAYVEFFCAKEKLDQLIEKS---KAFPSLTYIAVNKEGESISNIPANAVNAVT 1608
              G +YQKA+VE F  +++ +  ++           +Y A +  G   +N+  ++ + VT
Sbjct: 519  AKGRLYQKAFVEMFIHRQQWETTLKPKLDHYGRRKFSYYAGDSSGSFETNLDPHSSSVVT 578

Query: 1609 WGVFPGKEIIQPTVVDSASFMVWKDEAFEIWSRGWACLFPEGDSSRELLEQVQKTYCLVS 1788
            WGVFP   + Q T+++  SF  W+DEAF IWS  WA LFP    +  LL  V K YCLVS
Sbjct: 579  WGVFPNSPVKQTTIIEEESFKAWRDEAFSIWSE-WAKLFPRNTPANILLRLVHKDYCLVS 637

Query: 1789 LVDNDYISGD 1818
            +V +D+   D
Sbjct: 638  IVHHDFKETD 647

>O67422:METF_AQUAE 5,10-methylenetetrahydrofolate reductase - Aquifex aeolicus|
          Length = 296

 Score =  211 bits (537), Expect = 9e-54
 Identities = 112/291 (38%), Positives = 154/291 (52%)
 Frame = +1

Query: 76  KIQEAAANGRTVFSFEYFPPKTEEGFENLFERMDRMVAHGPNFCDITWGAGGSTADVTLD 255
           KI +    G    SFE+FPPKTEEG   LFE + ++    P F  +T+GAGGST D T +
Sbjct: 2   KIGDILRKGVFSISFEFFPPKTEEGERQLFETIRKLEKLNPTFVSVTYGAGGSTRDRTRN 61

Query: 256 IANRMQNMVCVETMMHLTCTNMPVEKIDNALDTIKNNGIQNVLALRGDPPHGQDKFVQVA 435
           I  ++     +  M HLTC     E++ + L   KN GI+N+LALRGD P  +  +    
Sbjct: 62  IVQKIHEETNLTVMAHLTCIAHTREELIDILQDYKNIGIENILALRGDVPRDKPDWRPPK 121

Query: 436 GGFSCALDLVQHIRAKYGDYFGITVAGYPEAHPEVILGEDGATEEAYSKDLAYLKRKVDA 615
           G    A +LV+ IR ++GD+F I VA YPE HPE               ++ Y K KV+A
Sbjct: 122 GACKYAKELVELIRKEFGDWFSIGVASYPEGHPE---------SPNLEWEVKYFKEKVEA 172

Query: 616 GADVIVTQLFYDTDIFLKFVNDCRQIGITCPIVPGIMPINNYKGFVRMTGFCKTKIPAEI 795
           GAD  +TQ+F+  D + +FV  C+  GI   I+PGIMPI N+K   +    C   IP  +
Sbjct: 173 GADFSITQMFFVNDYYYRFVEMCKNAGIDISIIPGIMPITNFKQIRKFASLCGATIPQSL 232

Query: 796 TAALDPIKDNEEAVKAYGIHLGTEMCKKILASGIKTLHLYTLNMEKTALAI 948
              L+ ++D  E VK  GI      C  ++  G+  LH YTLN     L I
Sbjct: 233 IEKLEKVEDKPEEVKKIGIEFAINQCLDLIEHGVPGLHFYTLNKSDATLKI 283

>P0AEZ2:METF_SHIFL 5,10-methylenetetrahydrofolate reductase - Shigella flexneri|
          Length = 296

 Score =  172 bits (437), Expect = 4e-42
 Identities = 101/293 (34%), Positives = 154/293 (52%)
 Frame = +1

Query: 88  AAANGRTVFSFEYFPPKTEEGFENLFERMDRMVAHGPNFCDITWGAGGSTADVTLDIANR 267
           A   G+   SFE+FPP+T E  + L+  +DR+ +  P F  +T+GA     D T  I   
Sbjct: 17  AEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKG 76

Query: 268 MQNMVCVETMMHLTCTNMPVEKIDNALDTIKNNGIQNVLALRGDPPHGQDKFVQVAGGFS 447
           +++   +E   HLTC +   +++        NNGI++++ALRGD P G  K    A    
Sbjct: 77  IKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMYAS--- 133

Query: 448 CALDLVQHIRAKYGDYFGITVAGYPEAHPEVILGEDGATEEAYSKDLAYLKRKVDAGADV 627
              DLV  ++ +  D F I+VA YPE HPE          ++   DL  LKRKVDAGA+ 
Sbjct: 134 ---DLVTLLK-EVAD-FDISVAAYPEVHPEA---------KSAQADLLNLKRKVDAGANR 179

Query: 628 IVTQLFYDTDIFLKFVNDCRQIGITCPIVPGIMPINNYKGFVRMTGFCKTKIPAEITAAL 807
            +TQ F+D + +L+F + C   GI   I+PGI+P++N+K   +       +IPA +    
Sbjct: 180 AITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMF 239

Query: 808 DPIKDNEEAVKAYGIHLGTEMCKKILASGIKTLHLYTLNMEKTALAILMNLGL 966
           D + D+ E  K  G ++  +M K +   G+K  H YTLN  + + AI   LG+
Sbjct: 240 DGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGV 292

>P0AEZ1:METF_ECOLI 5,10-methylenetetrahydrofolate reductase - Escherichia coli|
          Length = 296

 Score =  172 bits (437), Expect = 4e-42
 Identities = 101/293 (34%), Positives = 154/293 (52%)
 Frame = +1

Query: 88  AAANGRTVFSFEYFPPKTEEGFENLFERMDRMVAHGPNFCDITWGAGGSTADVTLDIANR 267
           A   G+   SFE+FPP+T E  + L+  +DR+ +  P F  +T+GA     D T  I   
Sbjct: 17  AEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKG 76

Query: 268 MQNMVCVETMMHLTCTNMPVEKIDNALDTIKNNGIQNVLALRGDPPHGQDKFVQVAGGFS 447
           +++   +E   HLTC +   +++        NNGI++++ALRGD P G  K    A    
Sbjct: 77  IKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMYAS--- 133

Query: 448 CALDLVQHIRAKYGDYFGITVAGYPEAHPEVILGEDGATEEAYSKDLAYLKRKVDAGADV 627
              DLV  ++ +  D F I+VA YPE HPE          ++   DL  LKRKVDAGA+ 
Sbjct: 134 ---DLVTLLK-EVAD-FDISVAAYPEVHPEA---------KSAQADLLNLKRKVDAGANR 179

Query: 628 IVTQLFYDTDIFLKFVNDCRQIGITCPIVPGIMPINNYKGFVRMTGFCKTKIPAEITAAL 807
            +TQ F+D + +L+F + C   GI   I+PGI+P++N+K   +       +IPA +    
Sbjct: 180 AITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPAWMAQMF 239

Query: 808 DPIKDNEEAVKAYGIHLGTEMCKKILASGIKTLHLYTLNMEKTALAILMNLGL 966
           D + D+ E  K  G ++  +M K +   G+K  H YTLN  + + AI   LG+
Sbjct: 240 DGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGV 292

>P11003:METF_SALTY 5,10-methylenetetrahydrofolate reductase - Salmonella typhimurium|
          Length = 296

 Score =  167 bits (422), Expect = 2e-40
 Identities = 97/293 (33%), Positives = 154/293 (52%)
 Frame = +1

Query: 88  AAANGRTVFSFEYFPPKTEEGFENLFERMDRMVAHGPNFCDITWGAGGSTADVTLDIANR 267
           A   G+   SFE+FPP+T E  + L+  +DR+ +  P F  +T+GA     D T  +   
Sbjct: 17  AEVQGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSVIKG 76

Query: 268 MQNMVCVETMMHLTCTNMPVEKIDNALDTIKNNGIQNVLALRGDPPHGQDKFVQVAGGFS 447
           ++    +E   HLTC +   +++        NNGI++++ALRGD P G  K    A    
Sbjct: 77  IKERTGLEAAPHLTCIDATRDELRTIARDYWNNGIRHIVALRGDLPPGSGKPEMYAA--- 133

Query: 448 CALDLVQHIRAKYGDYFGITVAGYPEAHPEVILGEDGATEEAYSKDLAYLKRKVDAGADV 627
              DLV  ++ +  D F I+VA YPE HPE          ++   DL  LKRKVDAGA+ 
Sbjct: 134 ---DLVGLLK-EVAD-FDISVAAYPEVHPEA---------KSAQADLLNLKRKVDAGANR 179

Query: 628 IVTQLFYDTDIFLKFVNDCRQIGITCPIVPGIMPINNYKGFVRMTGFCKTKIPAEITAAL 807
            +TQ F+D + +L+F + C   GI   I+PGI+P++N+K   +       +IP+ ++   
Sbjct: 180 AITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADMTNVRIPSWMSLMF 239

Query: 808 DPIKDNEEAVKAYGIHLGTEMCKKILASGIKTLHLYTLNMEKTALAILMNLGL 966
           + + ++ E  K  G ++  +M K +   G+K  H YTLN  + + AI   LG+
Sbjct: 240 EGLDNDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLGV 292

>O54235:METF_STRLI 5,10-methylenetetrahydrofolate reductase - Streptomyces lividans|
          Length = 307

 Score =  166 bits (421), Expect = 3e-40
 Identities = 97/297 (32%), Positives = 155/297 (52%), Gaps = 1/297 (0%)
 Frame = +1

Query: 79  IQEAAANGRTVFSFEYFPPKTEEGFENLFERMDRMVAHGPNFCDITWGAGGSTADVTLDI 258
           +++  A G+T +SFE+  PKT +G +NL+  + R+ A  P+F  +T+GAGGST   T+  
Sbjct: 16  VRDILATGKTTYSFEFSAPKTPKGEKNLWSALRRVEAVAPDFVSVTYGAGGSTRAGTVRE 75

Query: 259 ANRMQNMVCVETMMHLTCTNMPVEKIDNALDTIKNNGIQNVLALRGDPPHGQDK-FVQVA 435
             ++     +  + HLT  +  V ++ N +    + GI+N+LA+RGDPP   +  ++   
Sbjct: 76  TQQIVADTTLTPVAHLTAVDHSVAELRNIIGQYADAGIRNMLAVRGDPPGDPNADWIAHP 135

Query: 436 GGFSCALDLVQHIRAKYGDYFGITVAGYPEAHPEVILGEDGATEEAYSKDLAYLKRKVDA 615
            G + A +LV+ I+   GD F + VA +PE HP             +  D+     K  A
Sbjct: 136 EGLTYAAELVRLIKES-GD-FCVGVAAFPEMHPR---------SADWDTDVTNFVDKCRA 184

Query: 616 GADVIVTQLFYDTDIFLKFVNDCRQIGITCPIVPGIMPINNYKGFVRMTGFCKTKIPAEI 795
           GAD  +TQ+F+  D +L+  +     G   P++P +MP+ + K   R+        PAE+
Sbjct: 185 GADYAITQMFFQPDSYLRLRDRVAAAGCATPVIPEVMPVTSVKMLERLPKLSNASFPAEL 244

Query: 796 TAALDPIKDNEEAVKAYGIHLGTEMCKKILASGIKTLHLYTLNMEKTALAILMNLGL 966
              +   KD+  AV++ GI   TE C ++LA G+  LH  TLN     L I  NLGL
Sbjct: 245 KERILTAKDDPAAVRSIGIEFATEFCARLLAEGVPGLHFITLNNSTATLEIYENLGL 301

>P71319:METF_PECCC 5,10-methylenetetrahydrofolate reductase - Pectobacterium|
           carotovorum subsp. carotovorum (Erwinia carotovora
           subsp. carotovora)
          Length = 298

 Score =  165 bits (418), Expect = 6e-40
 Identities = 98/293 (33%), Positives = 150/293 (51%)
 Frame = +1

Query: 88  AAANGRTVFSFEYFPPKTEEGFENLFERMDRMVAHGPNFCDITWGAGGSTADVTLDIANR 267
           A   GR   SFE+FPP+T +  E L+  +DR+ +  P F  +T+GA     D T  I   
Sbjct: 17  AELQGRINVSFEFFPPRTSDMEETLWSSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKT 76

Query: 268 MQNMVCVETMMHLTCTNMPVEKIDNALDTIKNNGIQNVLALRGDPPHGQDKFVQVAGGFS 447
           ++    +E   HLTC +   E++         +GI++++ALRGD P    K    A    
Sbjct: 77  IKERTGLEAAPHLTCIDASREQLREIAQDYWESGIRHIVALRGDLPQEGGKPDMYAA--- 133

Query: 448 CALDLVQHIRAKYGDYFGITVAGYPEAHPEVILGEDGATEEAYSKDLAYLKRKVDAGADV 627
              DLV  ++ + GD F I+VA YPE HPE          ++   DL  LK K+DAGA+ 
Sbjct: 134 ---DLVSLLK-EVGD-FDISVAAYPEVHPEA---------KSAQADLINLKHKIDAGANR 179

Query: 628 IVTQLFYDTDIFLKFVNDCRQIGITCPIVPGIMPINNYKGFVRMTGFCKTKIPAEITAAL 807
            +TQ F+D + +L+F + C   GI   IVPGI+P++N+K   +       ++P  +T   
Sbjct: 180 AITQFFFDVESYLRFRDRCVATGIDVEIVPGILPVSNFKQLQKFATMTNVRVPNWMTTMF 239

Query: 808 DPIKDNEEAVKAYGIHLGTEMCKKILASGIKTLHLYTLNMEKTALAILMNLGL 966
           D + ++ E  K  G  +  +M K +   G+K  H YTLN  + + AI   LG+
Sbjct: 240 DGLDNDPETRKMVGASIAMDMVKILSREGVKDFHFYTLNRAELSYAICHTLGV 292

>P45208:METF_HAEIN 5,10-methylenetetrahydrofolate reductase - Haemophilus influenzae|
          Length = 292

 Score =  160 bits (404), Expect = 2e-38
 Identities = 97/290 (33%), Positives = 146/290 (50%)
 Frame = +1

Query: 97  NGRTVFSFEYFPPKTEEGFENLFERMDRMVAHGPNFCDITWGAGGSTADVTLDIANRMQN 276
           N +   SFE+FPPK E+    L++ + R+    P F  +T+GA     D T  I   ++ 
Sbjct: 18  NKKINVSFEFFPPKNEKMETLLWDSIHRLKVLKPKFVSVTYGANSGERDRTHGIVKAIKQ 77

Query: 277 MVCVETMMHLTCTNMPVEKIDNALDTIKNNGIQNVLALRGDPPHGQDKFVQVAGGFSCAL 456
              +E   HLT  +   E++        ++GI+ ++ALRGD P G  K    A       
Sbjct: 78  ETGLEAAPHLTGIDATPEELKQIARDYWDSGIRRIVALRGDEPKGYAKKPFYAS------ 131

Query: 457 DLVQHIRAKYGDYFGITVAGYPEAHPEVILGEDGATEEAYSKDLAYLKRKVDAGADVIVT 636
           DLV+ +R+     F I+VA YPE HPE          ++   DL  LKRK+DAGA+ ++T
Sbjct: 132 DLVELLRSVAD--FDISVAAYPEVHPEA---------KSAQADLINLKRKIDAGANHVIT 180

Query: 637 QLFYDTDIFLKFVNDCRQIGITCPIVPGIMPINNYKGFVRMTGFCKTKIPAEITAALDPI 816
           Q F+D + +L+F + C  IGI   IVPGI+P+ N+K   +M  F   KIPA +  A D +
Sbjct: 181 QFFFDIENYLRFRDRCASIGIDTEIVPGILPVTNFKQLQKMASFTNVKIPAWLVKAYDGL 240

Query: 817 KDNEEAVKAYGIHLGTEMCKKILASGIKTLHLYTLNMEKTALAILMNLGL 966
            ++          +  +M K +   G+   H YTLN  +   AI   LG+
Sbjct: 241 DNDPTTRNLVAASVAMDMVKILSREGVNDFHFYTLNRSELTYAICHMLGV 290

>P57154:METF_BUCAI 5,10-methylenetetrahydrofolate reductase - Buchnera aphidicola|
           subsp. Acyrthosiphon pisum (Acyrthosiphon pisum
           symbiotic bacterium)
          Length = 292

 Score =  149 bits (375), Expect = 5e-35
 Identities = 91/284 (32%), Positives = 141/284 (49%)
 Frame = +1

Query: 115 SFEYFPPKTEEGFENLFERMDRMVAHGPNFCDITWGAGGSTADVTLDIANRMQNMVCVET 294
           SFE+FPPK     ENL+  ++R+    P F  +T+GA     + T D   ++     + T
Sbjct: 26  SFEFFPPKNSFLEENLWSTVNRLSLLKPKFFSVTYGANTGEREKTYDTVQKIYKKTGIIT 85

Query: 295 MMHLTCTNMPVEKIDNALDTIKNNGIQNVLALRGDPPHGQDKFVQVAGGFSCALDLVQHI 474
             HLTC +    K+        N+GI++++ALRGD      +    A      +DLV  +
Sbjct: 86  AAHLTCIDSTPHKLKEIAYNYWNSGIKSIVALRGDTLEKDYRHTMYA------VDLVLLL 139

Query: 475 RAKYGDYFGITVAGYPEAHPEVILGEDGATEEAYSKDLAYLKRKVDAGADVIVTQLFYDT 654
           + K  D F I+VA YPE HPE          +    D+  LK+KVDAGA   +TQ F++ 
Sbjct: 140 K-KIAD-FDISVAAYPELHPE---------SKNVKSDILNLKKKVDAGASRAITQFFFNI 188

Query: 655 DIFLKFVNDCRQIGITCPIVPGIMPINNYKGFVRMTGFCKTKIPAEITAALDPIKDNEEA 834
           + +L+F ++C +  I   I+PGI+P+ N++   R +     KIP  +    + + D+   
Sbjct: 189 ESYLRFRDNCIKNKINIDIIPGILPVCNFQKLKRFSSMTNVKIPKWMLDMFNGLDDDIFT 248

Query: 835 VKAYGIHLGTEMCKKILASGIKTLHLYTLNMEKTALAILMNLGL 966
            K  G  +  +M KK+   G+K  H YTLN      +I   LGL
Sbjct: 249 QKIIGSSIAIDMVKKLSCEGVKNFHFYTLNQSDITYSICHILGL 292

>Q89B13:METF_BUCBP 5,10-methylenetetrahydrofolate reductase - Buchnera aphidicola|
           subsp. Baizongia pistaciae
          Length = 295

 Score =  145 bits (367), Expect = 5e-34
 Identities = 93/300 (31%), Positives = 152/300 (50%), Gaps = 1/300 (0%)
 Frame = +1

Query: 52  QRKMKVIEKIQEAAANGRTVFSFEYFPPKTEEGFENLFERMDRMVAHGPNFCDITWGAGG 231
           Q  M + EK+           SFE+FPP      +NL++ +D++    P F  +T G   
Sbjct: 14  QHLMNICEKVN---------ISFEFFPPNNILSEKNLWQVIDKLKLLTPKFFSVTHGTNS 64

Query: 232 ST-ADVTLDIANRMQNMVCVETMMHLTCTNMPVEKIDNALDTIKNNGIQNVLALRGDPPH 408
              A  T +I  +++    +ET+ HLTC N   E++     T  ++GI+++LALRGD  +
Sbjct: 65  KIRATCTSNIVKKIKKYTGIETVPHLTCINSTEEELKVIAKTYWDSGIRHILALRGDIFN 124

Query: 409 GQDKFVQVAGGFSCALDLVQHIRAKYGDYFGITVAGYPEAHPEVILGEDGATEEAYSKDL 588
              K          A+DL++ +++     F I+VA YPE HPE +  +          D+
Sbjct: 125 TNCK------PKIYAVDLIKLLKSIAN--FEISVAAYPEVHPEAVNAK---------YDI 167

Query: 589 AYLKRKVDAGADVIVTQLFYDTDIFLKFVNDCRQIGITCPIVPGIMPINNYKGFVRMTGF 768
             LKRKV+AGA   +TQ F++ D FL+F + C +  IT  IVPGI PI+N+K  ++ +  
Sbjct: 168 INLKRKVEAGATRAITQFFFNIDCFLRFRDLCVKNNITIDIVPGIFPISNFKQLLKFSSV 227

Query: 769 CKTKIPAEITAALDPIKDNEEAVKAYGIHLGTEMCKKILASGIKTLHLYTLNMEKTALAI 948
               IP  +      + ++    +  G  +  +M K + + GI++ H YTLN  + + AI
Sbjct: 228 SNVSIPKWLCCMFHGLDNDLNTSRIIGSSIAIDMVKVLYSEGIRSFHFYTLNKSEISFAI 287

>Q8KA62:METF_BUCAP 5,10-methylenetetrahydrofolate reductase - Buchnera aphidicola|
           subsp. Schizaphis graminum
          Length = 292

 Score =  141 bits (356), Expect = 9e-33
 Identities = 91/292 (31%), Positives = 145/292 (49%), Gaps = 2/292 (0%)
 Frame = +1

Query: 97  NGRTVFSFEYFPPKTEEGFENLFERMDRMVAHGPNFCDITWGAGGSTADVTLDIANRMQN 276
           N +   SFE+FPPK  +  + LF  + ++    P    +T+GA       T  I  R+  
Sbjct: 20  NDKIQCSFEFFPPKNLDTEKKLFSSVVKLSLLKPFLFSVTYGANSGERKKTYSIVQRIHK 79

Query: 277 MVCVETMMHLTCTNMPVEKIDNALDTIKNNGIQNVLALRGDPPHG--QDKFVQVAGGFSC 450
              + T  HLTC +  + ++         NGI++++ALRGD P+   Q K          
Sbjct: 80  KTGITTAPHLTCVDASLSELKEIAKFYWENGIRSIVALRGDVPNKSYQHKIY-------- 131

Query: 451 ALDLVQHIRAKYGDYFGITVAGYPEAHPEVILGEDGATEEAYSKDLAYLKRKVDAGADVI 630
           ALDLV  ++ K  D F I+VA YPE HPE        ++ A S D+  LK+K DAGA+  
Sbjct: 132 ALDLVVLLK-KIAD-FDISVAAYPEIHPE--------SKNAQS-DILNLKKKADAGANRA 180

Query: 631 VTQLFYDTDIFLKFVNDCRQIGITCPIVPGIMPINNYKGFVRMTGFCKTKIPAEITAALD 810
           +TQ F++ + +L+F ++C +  I   I+PGI+PI N++   + +      IP  +    +
Sbjct: 181 ITQFFFNVESYLRFRDNCIKNNINIEIIPGILPIYNFEQLKKFSSMTNVSIPKWMFEMFN 240

Query: 811 PIKDNEEAVKAYGIHLGTEMCKKILASGIKTLHLYTLNMEKTALAILMNLGL 966
            + ++ E  K  G ++   + K +L  G+K  H YTLN      +I    GL
Sbjct: 241 GLDEDLETQKIIGSNIVINIVKTLLYEGVKNFHFYTLNKSDVIYSICHMFGL 292

>Q8K0Z7:CCD44_MOUSE Coiled-coil domain-containing protein 44 - Mus musculus (Mouse)|
          Length = 294

 Score = 36.2 bits (82), Expect = 0.52
 Identities = 33/128 (25%), Positives = 57/128 (44%), Gaps = 2/128 (1%)
 Frame = +1

Query: 316 NMPVEKIDNALDTIKNNGIQNVLALRGDPPHGQDKFVQVA--GGFSCALDLVQHIRAKYG 489
           NMP   I++AL T KN GI   L   G  P G    ++     G  C LD +++I  K G
Sbjct: 113 NMPKSTIESALKTEKNKGI--YLLYEGRGPGGSSLLIEALSNSGPKCHLD-IKYILNKNG 169

Query: 490 DYFGITVAGYPEAHPEVILGEDGATEEAYSKDLAYLKRKVDAGADVIVTQLFYDTDIFLK 669
                    + +    V++G +   ++A + + A L+  ++AGA+ +      +     K
Sbjct: 170 GMMAEGARHFFDKKGVVVVGVEDREKKAVNLERA-LELAIEAGAEDVKEAEDEEEKNLFK 228

Query: 670 FVNDCRQI 693
           F+ D   +
Sbjct: 229 FICDASSL 236

>Q9Y746:INV_KLULA Invertase precursor - Kluyveromyces lactis (Yeast) (Candida|
            sphaerica)
          Length = 609

 Score = 34.3 bits (77), Expect = 2.0
 Identities = 29/140 (20%), Positives = 51/140 (36%), Gaps = 8/140 (5%)
 Frame = +1

Query: 1060 NRPKSYISRTTGWDQYPQGRWGDSRNPSYGALNDHQFTRPRGRGKKLQEEWAVPLKSVQD 1239
            NRP  + S   GW   P G W D++   +     +    P          W +PL     
Sbjct: 44   NRPAVHYSPEEGWMNDPNGLWYDAKEEDWHIYYQYYPDAP---------HWGLPLTWGHA 94

Query: 1240 INERFVNFCEGKLKSSPWSELDGLQPETTIIDDQLVKMNSKGFLTINSQP--------AV 1395
            +++    + E  +   P  E  G    + +ID      N+ GF   ++ P         +
Sbjct: 95   VSKDLTVWDEQGVAFGPEFETAGAFSGSMVIDYN----NTSGFFNSSTDPRQRVVAIWTL 150

Query: 1396 NAEKSESPSVGWGGPGGYVY 1455
            +   SE+  + +   GGY +
Sbjct: 151  DYSGSETQQLSYSHDGGYTF 170

>P55849:DSC1_MOUSE Desmocollin-1 precursor - Mus musculus (Mouse)|
          Length = 886

 Score = 34.3 bits (77), Expect = 2.0
 Identities = 33/119 (27%), Positives = 53/119 (44%), Gaps = 8/119 (6%)
 Frame = +1

Query: 781  IPAEITAALDPIKDN-EEAVKAYGIHLGTEMCKKILASG-IKTLHLYTLNMEKTALAILM 954
            +P+ + A     K N EE +K+  + L ++   +IL  G I T H   L+ EK   +IL+
Sbjct: 37   VPSHLKAETPVGKVNLEECLKSPSLILSSDPAFRILEDGTIYTTHDLLLSSEKRGFSILL 96

Query: 955  NLGLIEESKLSRTLPWRPPTNVFRVKEDVRPIF------WANRPKSYISRTTGWDQYPQ 1113
            + G  +E K    +       VFR +    P+       WA  P S +  + G   +PQ
Sbjct: 97   SDGQGQEQKKLEVVLSAREKKVFRKRHTKEPVHNRSKRRWAPIPCSLMENSLG--PFPQ 153

>Q9V4C8:HCF_DROME Host cell factor - Drosophila melanogaster (Fruit fly)|
          Length = 1500

 Score = 33.9 bits (76), Expect = 2.6
 Identities = 19/60 (31%), Positives = 31/60 (51%), Gaps = 4/60 (6%)
 Frame = -3

Query: 1090 WSLKCNSLVCW--PRI*GEHPL*HGKH*--LVASKVMFLKAWIPLLIQDSSELLKRSFPC 923
            W L+ +S+  W  P+  GE PL    H   ++ +K+     W+PL+I DS    +R + C
Sbjct: 275  WLLETDSMT-WSKPKTSGEAPLPRSLHSSTMIGNKMYVFGGWVPLVINDSKSTTEREWKC 333

>Q3Z062:CDD_SHISS Cytidine deaminase - Shigella sonnei (strain Ss046)|
          Length = 294

 Score = 33.1 bits (74), Expect = 4.4
 Identities = 16/55 (29%), Positives = 30/55 (54%)
 Frame = +1

Query: 1267 EGKLKSSPWSELDGLQPETTIIDDQLVKMNSKGFLTINSQPAVNAEKSESPSVGW 1431
            +G++ S  ++E     P    +   L+ +N KG+   + Q AV AEK+++P + W
Sbjct: 219  DGRIFSGSYAENAAFNPTLPPLQGALILLNLKGYDYPDIQRAVLAEKADAPLIQW 273

>P0ABF7:CDD_SHIFL Cytidine deaminase - Shigella flexneri|
          Length = 294

 Score = 33.1 bits (74), Expect = 4.4
 Identities = 16/55 (29%), Positives = 30/55 (54%)
 Frame = +1

Query: 1267 EGKLKSSPWSELDGLQPETTIIDDQLVKMNSKGFLTINSQPAVNAEKSESPSVGW 1431
            +G++ S  ++E     P    +   L+ +N KG+   + Q AV AEK+++P + W
Sbjct: 219  DGRIFSGSYAENAAFNPTLPPLQGALILLNLKGYDYPDIQRAVLAEKADAPLIQW 273

>Q32EM3:CDD_SHIDS Cytidine deaminase - Shigella dysenteriae serotype 1 (strain Sd197)|
          Length = 294

 Score = 33.1 bits (74), Expect = 4.4
 Identities = 16/55 (29%), Positives = 30/55 (54%)
 Frame = +1

Query: 1267 EGKLKSSPWSELDGLQPETTIIDDQLVKMNSKGFLTINSQPAVNAEKSESPSVGW 1431
            +G++ S  ++E     P    +   L+ +N KG+   + Q AV AEK+++P + W
Sbjct: 219  DGRIFSGSYAENAAFNPTLPPLQGALILLNLKGYDYPDIQRAVLAEKADAPLIQW 273

>Q322V3:CDD_SHIBS Cytidine deaminase - Shigella boydii serotype 4 (strain Sb227)|
          Length = 294

 Score = 33.1 bits (74), Expect = 4.4
 Identities = 16/55 (29%), Positives = 30/55 (54%)
 Frame = +1

Query: 1267 EGKLKSSPWSELDGLQPETTIIDDQLVKMNSKGFLTINSQPAVNAEKSESPSVGW 1431
            +G++ S  ++E     P    +   L+ +N KG+   + Q AV AEK+++P + W
Sbjct: 219  DGRIFSGSYAENAAFNPTLPPLQGALILLNLKGYDYPDIQRAVLAEKADAPLIQW 273

>P0ABF6:CDD_ECOLI Cytidine deaminase - Escherichia coli|
          Length = 294

 Score = 33.1 bits (74), Expect = 4.4
 Identities = 16/55 (29%), Positives = 30/55 (54%)
 Frame = +1

Query: 1267 EGKLKSSPWSELDGLQPETTIIDDQLVKMNSKGFLTINSQPAVNAEKSESPSVGW 1431
            +G++ S  ++E     P    +   L+ +N KG+   + Q AV AEK+++P + W
Sbjct: 219  DGRIFSGSYAENAAFNPTLPPLQGALILLNLKGYDYPDIQRAVLAEKADAPLIQW 273

>Q8FFV3:CDD_ECOL6 Cytidine deaminase - Escherichia coli O6|
          Length = 294

 Score = 33.1 bits (74), Expect = 4.4
 Identities = 16/55 (29%), Positives = 30/55 (54%)
 Frame = +1

Query: 1267 EGKLKSSPWSELDGLQPETTIIDDQLVKMNSKGFLTINSQPAVNAEKSESPSVGW 1431
            +G++ S  ++E     P    +   L+ +N KG+   + Q AV AEK+++P + W
Sbjct: 219  DGRIFSGSYAENAAFNPTLPPLQGALILLNLKGYDYPDIQRAVLAEKADAPLIQW 273

>Q8X648:CDD_ECO57 Cytidine deaminase - Escherichia coli O157:H7|
          Length = 294

 Score = 33.1 bits (74), Expect = 4.4
 Identities = 16/55 (29%), Positives = 30/55 (54%)
 Frame = +1

Query: 1267 EGKLKSSPWSELDGLQPETTIIDDQLVKMNSKGFLTINSQPAVNAEKSESPSVGW 1431
            +G++ S  ++E     P    +   L+ +N KG+   + Q AV AEK+++P + W
Sbjct: 219  DGRIFSGSYAENAAFNPTLPPLQGALILLNLKGYDYPDIQRAVLAEKADAPLIQW 273

>P98118:PROS_RABIT Vitamin K-dependent protein S precursor - Oryctolagus cuniculus|
            (Rabbit)
          Length = 646

 Score = 32.3 bits (72), Expect = 7.5
 Identities = 14/43 (32%), Positives = 22/43 (51%)
 Frame = +1

Query: 1705 RGWACLFPEGDSSRELLEQVQKTYCLVSLVDNDYISGDLFAAF 1833
            RGW  +       +E+++Q QK +CLV++    Y  G   A F
Sbjct: 422  RGWNLMKQGASGVKEIIQQKQKKHCLVTVEKGSYYPGSGIAQF 464

>Q6MNG0:DNAJ_BDEBA Chaperone protein dnaJ - Bdellovibrio bacteriovorus|
          Length = 371

 Score = 32.0 bits (71), Expect = 9.8
 Identities = 35/136 (25%), Positives = 51/136 (37%), Gaps = 13/136 (9%)
 Frame = +1

Query: 409 GQDKFVQVAGG--FSCALDLVQHIRAKYGDYFGITVAGYPEAHPEVILGEDGATEEAYSK 582
           G D F +  GG  F+ A D+  H    +GD+FG  + G                E     
Sbjct: 71  GHDAFTRGGGGGGFTDAEDIFSHFGDIFGDFFGGGMGGQQRQ-------RRNRNEPRRGS 123

Query: 583 DLAYLK----RKVDAGADVIVTQLFYDTDIFLKFVNDCRQIGI-------TCPIVPGIMP 729
           DL Y+     + V  G   I  ++ +DTD   K  ++C+  G        TC    G   
Sbjct: 124 DLRYVTEITLKDVITG---IEKEIEFDTD---KNCDECKGTGAEKGSQVSTCGTCGGSGQ 177

Query: 730 INNYKGFVRMTGFCKT 777
           +   +GF  M   C T
Sbjct: 178 VVRQQGFFAMASTCPT 193


  Database: uniprot_sprot.fasta.out
    Posted date:  Jul 19, 2007  5:58 PM
  Number of letters in database: 100,686,439
  Number of sequences in database:  274,295
  
Lambda     K      H
   0.318    0.134    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 274295
Number of Hits to DB: 361,444,554
Number of extensions: 8541499
Number of successful extensions: 22453
Number of sequences better than 10.0: 36
Number of HSP's gapped: 22349
Number of HSP's successfully gapped: 38
Length of query: 660
Length of database: 100,686,439
Length adjustment: 120
Effective length of query: 540
Effective length of database: 67,771,039
Effective search space: 36596361060
Effective search space used: 36596361060
Neighboring words threshold: 12
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)