ナショナルバイオリソースプロジェクト
-Barley Genetic Resources Database-
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| Clone Name | FLbaf48j16 |
|---|---|
| Clone Library Name | barley_pub |
>Q05047:C72A1_CATRO Cytochrome P450 72A1 - Catharanthus roseus (Rosy periwinkle)| (Madagascar periwinkle) Length = 524 Score = 367 bits (941), Expect = e-100 Identities = 200/506 (39%), Positives = 294/506 (58%), Gaps = 3/506 (0%) Frame = +3 Query: 120 SWAWERLLVRLVWRPYAVARRHRAQGIHGPPYRFLRGSNEEVRRMKAETAHVVLHVRDHD 299 +WAW R+L + P + +R R QG G PYRFL G +E +M E + ++D Sbjct: 22 AWAW-RVLDWAWFTPKRIEKRLRQQGFRGNPYRFLVGDVKESGKMHQEALSKPMEF-NND 79 Query: 300 YLHRVAPHFLKWRAQYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHFPKNDAHPNXXX 479 + R+ PH YG W G PRI V + EL++++L+ S + D H Sbjct: 80 IVPRLMPHINHTINTYGRNSFTWMGRIPRIHVMEPELIKEVLTHSSKYQKNFDVHNPLVK 139 Query: 480 XXXXXXXXXXXXDWVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEI 659 W +HRR+I PAF ++K+K+M C +E+ A K + E+ Sbjct: 140 FLLTGVGSFEGAKWSKHRRIISPAFTLEKLKSMLPAFAICYHDMLTKWEKIAEKQGSHEV 199 Query: 660 QVEFDKSVQELTADIISHTAFGSSYKLGMEAFYAQKELQAIAISSLLNVQIPGFSYLPTK 839 + + LT+D+IS AFGS+Y+ G + F KEL + I + +V IPG+SYLPTK Sbjct: 200 DIF--PTFDVLTSDVISKVAFGSTYEEGGKIFRLLKELMDLTIDCMRDVYIPGWSYLPTK 257 Query: 840 RNRRKWMLEKKLRSTLMRIINSRLASQGSGYG--NDLLGLMLEG-CTETEQGGKQEQLSL 1010 RN+R + K++ L IIN R+ + +G +DLLG++LE E ++ G ++ + Sbjct: 258 RNKRMKEINKEITDMLRFIINKRMKALKAGEPGEDDLLGVLLESNIQEIQKQGNKKDGGM 317 Query: 1011 SMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGKGDPSGDNLG 1190 S+ +++ ECK F+FAG ETT +LLTWT LLS +PEWQER R EVL+ GK P + L Sbjct: 318 SINDVIEECKLFYFAGQETTGVLLTWTTILLSKHPEWQERAREEVLQAFGKNKPEFERLN 377 Query: 1191 KLKEMTMVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGED 1370 LK ++M+L+E LRLY P + + + D +G+ TIP +++ +HR+K +WGED Sbjct: 378 HLKYVSMILYEVLRLYPPVIDLTKIVHKDTKLGSYTIPAGTQVMLPTVMLHREKSIWGED 437 Query: 1371 ADQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSP 1550 A +FNPMRF +GVA A K L FS GPR C+GQNFA+L+AK +A +LQ+F F ++P Sbjct: 438 AMEFNPMRFVDGVANATKNNVTYLPFSWGPRVCLGQNFALLQAKLGLAMILQRFKFDVAP 497 Query: 1551 SYVHAPADFLTLRPKFGLPVVMKLLD 1628 SYVHAP LT++P+FG V+ K L+ Sbjct: 498 SYVHAPFTILTVQPQFGSHVIYKKLE 523
>Q27516:C13A8_CAEEL Putative cytochrome P450 CYP13A8 - Caenorhabditis elegans| Length = 509 Score = 139 bits (349), Expect = 5e-32 Identities = 109/433 (25%), Positives = 190/433 (43%), Gaps = 30/433 (6%) Frame = +3 Query: 330 KWRAQYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHF---PKNDAHPNXXXXXXXXXX 500 KW +YG+ + F G + + + D +LV++IL + +F N + Sbjct: 54 KWTKEYGKIYGFTEGMQKVMVISDPDLVQEILVKQYDNFYGRKHNPVQGDPDKDKDIHIV 113 Query: 501 XXXXXDWVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKS 680 W R R + PAF+ IK + TM Q E++ + + + Sbjct: 114 GAQGFRWKRLRTITAPAFSNGSIKKVLTTMEDSTQELMKKLREESENGKAVNMHLFY--- 170 Query: 681 VQELTADIISHTAFG--------SSYKLGMEAFYAQKELQAIAISSLLNVQIPGFSYLPT 836 QE T D+IS A G + ++ F+ Q S + +L Sbjct: 171 -QEYTFDVISRVAMGQPDSQMFKNPLLKDVKGFFEHNRWQIWMFSGGFPFAVSFLKWLFI 229 Query: 837 KRNRRKW----MLEKKLRSTLMRIINSRLASQGSGY----GNDLLGLMLEGCTETEQGGK 992 K + +++K + +M I R A + G D + + L E E G+ Sbjct: 230 KVGKFGAGPFIVVQKSVTDAVMSRIAQREADKKHGVEPGEAADYIDMFLNARAEVEHFGE 289 Query: 993 QEQ----------LSLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAE 1142 L+ +EI+ +C F AG++TT++ L++ + L++ P+ Q +L+ E Sbjct: 290 SNDEFHKSSSYNNRQLTTQEIISQCFVFLVAGFDTTAISLSYVTYFLALNPKIQSKLQDE 349 Query: 1143 VLREVGKGDPSGDNLGKLKEMTMVLHETLRLYGPALFM-QRKTTTDMVVGAITIPKEHAI 1319 V +E + + D L KLK M V+ E+LRL+ A F R+ + V+G + + Sbjct: 350 VDKECPNDEITFDQLSKLKYMDNVIKESLRLFPFASFANSRRCMRNTVIGEQIVEAGVDV 409 Query: 1320 VIGAPFMHRDKKVWGEDADQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEA 1499 +I +H DK VWG D ++F P R+ + + A L+F GPR C+G FA+LE Sbjct: 410 MIDTWTLHHDKNVWGNDVEEFKPERWDSPLT----PQQAYLSFGAGPRVCLGMRFALLEQ 465 Query: 1500 KSVMATVLQKFSF 1538 K +++ +L+K++F Sbjct: 466 KGLLSHILKKYTF 478
>Q09653:C13AA_CAEEL Putative cytochrome P450 CYP13A10 - Caenorhabditis elegans| Length = 519 Score = 137 bits (344), Expect = 2e-31 Identities = 112/442 (25%), Positives = 198/442 (44%), Gaps = 35/442 (7%) Frame = +3 Query: 318 PHFLK---WRAQYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHFPKNDAHP---NXXX 479 P +L+ W YG + + G + V D ++VRQI + +F +P + Sbjct: 52 PQYLQIRDWTKLYGPIYGYTEGTIKTLIVSDIDIVRQIFVEQYDNFYGRKLNPIQGDPEK 111 Query: 480 XXXXXXXXXXXXDWVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEI 659 W R R + P F+ + ++ + T+ A EEQ S+ Sbjct: 112 DERTNLFSAQGFRWKRLRAISSPTFSNNSLRKINVTVEDSAMELLRHIEEQTSEGQ---- 167 Query: 660 QVEFDKSVQELTADIISHTAFGSSYKLGMEAFYAQKELQAIAISSLLNVQIPGFSYLPTK 839 Q++ + QE T D I A G + M K ++AI + ++ + G + Sbjct: 168 QIDMLQFYQEFTMDTIGRIAMGQTDSQ-MFKNPLLKFVRAIFGDNRKHIPLIGGVFPTLA 226 Query: 840 RNRRKWMLEKKL---------RSTLMRIINSRLASQGS--------GYGNDLLGLMLEGC 968 + R +ML+ L T++ + +R+ + + G D + L LE Sbjct: 227 QVFRFFMLKFPLLGAANFIHVNKTVVTAVQNRIDQRENDRKNGIEIGEPQDFIDLFLEAR 286 Query: 969 TET-----EQGGKQEQLS------LSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYP 1115 + E G + S L+ +EI+ +C F AG++TT+L L++T FLL+ +P Sbjct: 287 ADDVEHFQENNGDFSKTSSYGNRQLTTQEIVGQCLVFLIAGFDTTALSLSYTTFLLATHP 346 Query: 1116 EWQERLRAEVLREVGKGDPSGDNLGKLKEMTMVLHETLRLYG-PALFMQRKTTTDMVVGA 1292 E Q++L+ E+ RE + S D+L KLK M ++ ETLRLY + R+ +G Sbjct: 347 EVQKKLQEEIERECIEPSISFDHLSKLKYMDCIIKETLRLYPLGTMANSRRCMRATKLGN 406 Query: 1293 ITIPKEHAIVIGAPFMHRDKKVWGEDADQFNPMRFANGVARAAKVPHALLAFSIGPRACI 1472 + + + + +H D K+WG+DA +F P R+ + ++F +GPR C+ Sbjct: 407 VEVEVGTMVQVDTWSLHTDTKIWGDDAKEFKPERWLDPNCDQVFQKGGYISFGLGPRQCV 466 Query: 1473 GQNFAMLEAKSVMATVLQKFSF 1538 G A +E K ++A +L+K++F Sbjct: 467 GMRLAYMEEKMLLAHILRKYTF 488
>Q27517:C13A3_CAEEL Putative cytochrome P450 CYP13A3 - Caenorhabditis elegans| Length = 520 Score = 134 bits (338), Expect = 1e-30 Identities = 115/432 (26%), Positives = 187/432 (43%), Gaps = 31/432 (7%) Frame = +3 Query: 333 WRAQYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHFPKNDAHP---NXXXXXXXXXXX 503 W +YG + F G + + V D E V ++ + +F +P + Sbjct: 60 WTKEYGPMYGFTDGVEKTLVVSDPEFVHEVFVKQFDNFYARKQNPLQGDPDKDPRIHLVT 119 Query: 504 XXXXDWVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSV 683 W R R + P F+ ++ + T+ + + K T ++ + Sbjct: 120 SQGHRWKRLRTLASPTFSNKSLRKIFSTV----EESVAEMMRHLEKGTAGGKTIDILEYY 175 Query: 684 QELTADIISHTAFGSSYKLGMEAFYAQKELQAIAISSLLNVQIPG------------FSY 827 QE T DII A G S + E + K + I G FS Sbjct: 176 QEFTMDIIGKIAMGQSGSMMFENPWLDKIRAIFNTRGNIIFIICGIVPFTGSIFRWFFSK 235 Query: 828 LPTKRNRRKWMLEKKLRSTL---MRIINSRLASQGSGYGNDLLGLMLEGCT-------ET 977 +PT + M ++ T R + + + SG D + L L+ ET Sbjct: 236 VPTAQTVTSLMHTLEIALTKRVEQRAADEKAGIESSGEPQDFIDLFLDVQADTDFLEDET 295 Query: 978 EQGGKQEQL-----SLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAE 1142 + G + Q+ L+ +EI+ + F AGY+TT+L L+++ +LL+ +PE Q++L+ E Sbjct: 296 KNGFARSQIVKVDKHLTFDEIIGQLFVFLLAGYDTTALSLSYSSYLLARHPEIQKKLQEE 355 Query: 1143 VLREVGKGDPSGDNLGKLKEMTMVLHETLRLYGPA-LFMQRKTTTDMVVGAITIPKEHAI 1319 V RE + + D L KLK M V+ ETLRLY A + RK V + I + + Sbjct: 356 VDRECPDPEVTFDQLSKLKYMECVIKETLRLYPLASIVHNRKCMKSTTVLGMKIEEGTNV 415 Query: 1320 VIGAPFMHRDKKVWGEDADQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEA 1499 +H D K WGE+A++F P R+ +G +A A L F +GPR CIG A +E Sbjct: 416 QADTWTLHYDPKFWGENANEFKPERWESGDEQAV-AKGAYLPFGLGPRICIGMRLAYMEE 474 Query: 1500 KSVMATVLQKFS 1535 K ++A +L+K+S Sbjct: 475 KMLLAQILKKYS 486
>Q27515:C13A6_CAEEL Putative cytochrome P450 CYP13A6 - Caenorhabditis elegans| Length = 518 Score = 132 bits (332), Expect = 5e-30 Identities = 109/443 (24%), Positives = 191/443 (43%), Gaps = 36/443 (8%) Frame = +3 Query: 318 PHFLK---WRAQYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHFPKNDAHP---NXXX 479 P FLK W QYG + F G + + + + E+V +I + +F P + Sbjct: 50 PPFLKYRDWTKQYGPVYGFTEGPQQTMIISEPEMVNEIFKKQFDNFYGRKLRPIIGDPEK 109 Query: 480 XXXXXXXXXXXXDWVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEI 659 W R R + P+F+ + ++ + ++ C E++ KN + ++ Sbjct: 110 DKRVNIFSTQGKRWKRLRTLSSPSFSNNSLRKVRNSVQECGTEILWNIEQKVRKNEDIDM 169 Query: 660 QVEFDKSVQELTADIISHTAFGSSYKLGMEAFYAQKELQAIAISSLLNVQIPGFSYLPTK 839 + + QE T +IS A G S + M ++QAI S I G + P Sbjct: 170 LIVY----QEYTLGVISRIALGQS-ESNMFKNPLLPKVQAIFNGSWHVFLITGI-FPPLA 223 Query: 840 RNRRKW----------------MLEKKLRSTLMRIINSRLASQGSGYGNDLLGLMLEGCT 971 RK ++E +++ + + + G D + L L+ Sbjct: 224 GVFRKMSKMLPASFIPAFKIFDLIEVAVQARIDQRAKDEIKGVEPGEPQDFIDLFLDARV 283 Query: 972 ETEQ---GGKQEQLS----------LSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVY 1112 + G E + L+ +EI+ +C F AG++TT+L L++ +LL+ + Sbjct: 284 PDVKILSGEANEDFAKSSVVKINKELTFDEIIAQCFVFLAAGFDTTALSLSYATYLLATH 343 Query: 1113 PEWQERLRAEVLREVGKGDPSGDNLGKLKEMTMVLHETLRLYGPALFMQ-RKTTTDMVVG 1289 PE Q +L+ EV RE + D+L KLK + V+ ETLRLY RK + + Sbjct: 344 PEIQTKLQEEVDRECPDPEIFFDHLSKLKYLECVMKETLRLYPLGTTANTRKCMRETTIN 403 Query: 1290 AITIPKEHAIVIGAPFMHRDKKVWGEDADQFNPMRFANGVARAAKVPHALLAFSIGPRAC 1469 + + I + +H + ++WGED + F P R+ NG + + + F GPR C Sbjct: 404 GVNFDEGMNIQVDTWTLHHNPRIWGEDVEDFKPERWENGACEHLEHNGSYIPFGSGPRQC 463 Query: 1470 IGQNFAMLEAKSVMATVLQKFSF 1538 IG A +E K ++A +L+++SF Sbjct: 464 IGMRLAQMEQKILLAQILKEYSF 486
>P24463:CP3AC_CANFA Cytochrome P450 3A12 - Canis familiaris (Dog)| Length = 503 Score = 131 bits (329), Expect = 1e-29 Identities = 110/414 (26%), Positives = 189/414 (45%), Gaps = 10/414 (2%) Frame = +3 Query: 327 LKWRAQYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHFPKNDAHPNXXXXXXXXXXXX 506 +K ++YG + F+ G +P + + D ++++ +L + N Sbjct: 62 MKCFSKYGRMWGFYDGRQPVLAITDPDMIKTVLVKECYSVFTNRRTLGPVGFMKSAISLS 121 Query: 507 XXXDWVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQ 686 +W R R ++ P F K+K M + ++A K ++ F Sbjct: 122 EDEEWKRMRTLLSPTFTTGKLKEMFPIIGQYGDVLVNNLRKEAEKGKAINLKDVFGA--- 178 Query: 687 ELTADIISHTAFG---SSYKLGMEAFYAQ-KELQAIAISSLLNVQIPGFSYL-PTKRNRR 851 + D+I+ T+FG S + F K+L I F +L P Sbjct: 179 -YSMDVITSTSFGVNIDSLNHPQDPFVENTKKLLKFDFLDPFFFSILLFPFLTPVFEILN 237 Query: 852 KWMLEKKL----RSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGGKQEQLSLSME 1019 W+ KK+ R ++ R+ SRL + + D L LM+ E + +LS Sbjct: 238 IWLFPKKVTDFFRKSVERMKESRLKDKQK-HRVDFLQLMINSQNSKEMDTHK---ALSDL 293 Query: 1020 EILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREV-GKGDPSGDNLGKL 1196 E++ + F FAGYETTS L++ ++ L+ +P+ Q++L+ E+ K P+ D L ++ Sbjct: 294 ELVAQSIIFIFAGYETTSTSLSFLMYELATHPDVQQKLQEEIDATFPNKALPTYDALVQM 353 Query: 1197 KEMTMVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDAD 1376 + + MVL+ETLRLY A ++R D+ + + IPK +++ +HRD+ +W E + Sbjct: 354 EYLDMVLNETLRLYPIAGRLERVCKKDVEISGVFIPKGTVVMVPTFTLHRDQSLWPE-PE 412 Query: 1377 QFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSF 1538 +F P RF+ + P+ L F GPR CIG FA++ K + VLQ FSF Sbjct: 413 EFRPERFSRKNKDSIN-PYTYLPFGTGPRNCIGMRFAIMNMKLALVRVLQNFSF 465
>P14581:CP4A7_RABIT Cytochrome P450 4A7 precursor - Oryctolagus cuniculus (Rabbit)| Length = 511 Score = 130 bits (328), Expect = 1e-29 Identities = 114/387 (29%), Positives = 178/387 (45%), Gaps = 18/387 (4%) Frame = +3 Query: 519 WVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQELTA 698 W +HRR++ PAF D +K MV Q V ++ K K+ +E + V +T Sbjct: 139 WFQHRRMLTPAFHYDILKPYVGLMVDSVQ----VMLDKLEKLARKDAPLEIYEHVSLMTL 194 Query: 699 DIISHTAFGSSYKLGMEA------FYAQKELQAIAISSLLNV-QIPGFSYLPTKRNRRKW 857 + I AF + +E+ A +EL +A+ + NV F Y + R Sbjct: 195 ETIMKCAFSHQGSVQLESRTSKSYIQAVRELSDLALQRVRNVFHQSDFLYRLSPEGRLSH 254 Query: 858 MLEKKLRSTLMRIINSRLAS-QGSGYGN--------DLLGLMLEGCTETEQGGKQEQLSL 1010 + R+I R A Q G D L ++L + E G SL Sbjct: 255 RACQLAHEHTDRVIQQRKAQLQQEGELEKVRRKRRLDFLDVLL--FAKMENGS-----SL 307 Query: 1011 SMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGKGDP-SGDNL 1187 S +++ E TF F G++TT+ ++W + L+ +PE Q R R E+ +G G + ++L Sbjct: 308 SDQDLRAEVDTFMFEGHDTTASGISWIFYALATHPEHQHRCREEIQGLLGDGASITWEHL 367 Query: 1188 GKLKEMTMVLHETLRLYGPALFMQRKTTTDMVV-GAITIPKEHAIVIGAPFMHRDKKVWG 1364 K+ TM + E LRLY P + K ++ + ++PK I + +H + KVW Sbjct: 368 DKMPYTTMCIKEALRLYPPVPGVGSKLSSPVTFPDGRSLPKGIIITLSIYGLHHNPKVW- 426 Query: 1365 EDADQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFAL 1544 + + F+P RFA G AR + HA L FS G R CIG+ FAM E K +A L +F Sbjct: 427 PNPEVFDPSRFAPGSARHS---HAFLPFSGGSRNCIGKQFAMNELKVAVALTLVRFELLP 483 Query: 1545 SPSYVHAPADFLTLRPKFGLPVVMKLL 1625 P+ V P L L+ K G+ + ++ L Sbjct: 484 DPTRVPIPITRLVLKSKNGIHLRLRKL 510
>O88833:CP4AA_MOUSE Cytochrome P450 4A10 - Mus musculus (Mouse)| Length = 509 Score = 129 bits (324), Expect = 4e-29 Identities = 120/450 (26%), Positives = 204/450 (45%), Gaps = 26/450 (5%) Frame = +3 Query: 354 PFLFWFGAKPRICVFDYELVRQILSSKSGHFPK-NDAHPNXXXXXXXXXXXXXXXDWVRH 530 P FW G+K + V+D + ++ IL PK N A+ W +H Sbjct: 86 PRWFW-GSKAYLTVYDPDYMKVILGRSD---PKANGAYRLLAPWIGYGLLLLNGQPWFQH 141 Query: 531 RRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQELTADIIS 710 RR++ PAF D +K K M + +E A ++++ +E + + +T D + Sbjct: 142 RRMLTPAFHYDILKPYVKNMADSIRLMLDKWERLADQDSS----IEIFQHISLMTLDTVM 197 Query: 711 HTAFGSSYKLGMEAFYAQKELQAIA-ISSLLNVQIPGFSYLPTKRNRRKWMLEKKLRSTL 887 AF + ++ Y + LQAI +++L + ++ + +N + L Sbjct: 198 KCAFSHKGSVQVDGNY-RTYLQAIGDLNNLFHSRVRNIFH----QNDTIYKLSS------ 246 Query: 888 MRIINSRLASQGSGYGND-------LLGLMLEGCTETEQGGKQEQL-------------- 1004 N RLA Q +D L L+ E E+ K+ +L Sbjct: 247 ----NGRLAKQACQLAHDHTDGVIKLRKDQLQDEGELEKIKKKRRLDFLDILLFARMENG 302 Query: 1005 -SLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGKGDP-SG 1178 S+S +++ E TF F G++TT+ ++W + L+ +P+ Q+R R EV +G G + Sbjct: 303 DSMSDKDLRAEVDTFMFEGHDTTASGVSWIFYALATHPDHQQRCREEVQSLLGDGSSITW 362 Query: 1179 DNLGKLKEMTMVLHETLRLYGPALFMQRKTTTDMVV-GAITIPKEHAIVIGAPFMHRDKK 1355 D+L ++ TM + E LRLY P + R+ +T + ++PK + + +H + K Sbjct: 363 DHLDQIPYTTMCIKEALRLYPPVPGIVRELSTSVTFPDGRSLPKGVQVTLSIYGLHHNPK 422 Query: 1356 VWGEDADQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFS 1535 VW + + F+P RFA R + H+ L FS G R CIG+ FAM E K ++A L +F Sbjct: 423 VW-PNPEVFDPSRFAPDSPRHS---HSFLPFSGGARNCIGKQFAMSELKVIVALTLLRFE 478 Query: 1536 FALSPSYVHAPADFLTLRPKFGLPVVMKLL 1625 P+ V P L L+ K G+ + +K L Sbjct: 479 LLPDPTRVPMPLARLVLKSKNGIYLHLKKL 508
>Q27514:C13A5_CAEEL Putative cytochrome P450 CYP13A5 - Caenorhabditis elegans| Length = 520 Score = 129 bits (323), Expect = 6e-29 Identities = 115/454 (25%), Positives = 191/454 (42%), Gaps = 36/454 (7%) Frame = +3 Query: 294 HDYLHRVAPHFLK---WRAQYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHFPKNDAH 464 H++ P LK W +YG + G + + V + E V ++ + +F + Sbjct: 44 HEFQDYENPGLLKLGEWTKEYGPIYGITEGVEKTLIVSNPEFVHEVFVKQFDNFYGRKTN 103 Query: 465 P---NXXXXXXXXXXXXXXXDWVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQA 635 P + W R R + P F+ ++ + T+ ++ + Sbjct: 104 PIQGDPNKNKRAHLVSAQGHRWKRLRTLSSPTFSNKNLRKIMSTVEETVVELMRHLDDAS 163 Query: 636 SKNTNKEIQVEFDKSVQELTADIISHTAFGSSYKLGMEAFYAQKELQAIAISSLLNVQIP 815 +K V+ QE T DII A G + L K L + Sbjct: 164 AKGK----AVDLLDYYQEFTLDIIGRIAMGQTESLMFRNPMLPKVKGIFKDGRKLPFLVS 219 Query: 816 GFSYLPTKRNRRKWMLEKKLR------STLMRIINSRLASQG---------SGYGNDLLG 950 G + R +M ++ ST+ + +N RL + SG D + Sbjct: 220 GIFPIAGTMFREFFMRFPSIQPAFDIMSTVEKALNKRLEQRAADEKAGIEPSGEPQDFID 279 Query: 951 LMLE--------------GCTETEQGGKQEQLSLSMEEILHECKTFFFAGYETTSLLLTW 1088 L L+ G +TE +QL+ +EI+ + F AGY+TT+L L++ Sbjct: 280 LFLDARANVDFFEEESALGFAKTEIAKVDKQLTF--DEIIGQLFVFLLAGYDTTALSLSY 337 Query: 1089 TVFLLSVYPEWQERLRAEVLREVGKGDPSGDNLGKLKEMTMVLHETLRLYGPA-LFMQRK 1265 + +LL+ +PE Q++L+ EV RE + + D + KLK M V+ E LR+Y A + RK Sbjct: 338 SSYLLARHPEIQKKLQEEVDRECPNPEVTFDQISKLKYMECVVKEALRMYPLASIVHNRK 397 Query: 1266 TTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDADQFNPMRFANGVARAAKVPHALLA 1445 + V + I K + + +H D KVWGEDA++F P R+ +G L Sbjct: 398 CMKETNVLGVQIEKGTNVQVDTWTLHYDPKVWGEDANEFRPERWESG-DELFYAKGGYLP 456 Query: 1446 FSIGPRACIGQNFAMLEAKSVMATVLQKFSFALS 1547 F +GPR CIG AM+E K ++ +L+K++F S Sbjct: 457 FGMGPRICIGMRLAMMEKKMLLTHILKKYTFETS 490
>Q27520:C13A1_CAEEL Putative cytochrome P450 CYP13A1 - Caenorhabditis elegans| Length = 519 Score = 129 bits (323), Expect = 6e-29 Identities = 105/433 (24%), Positives = 187/433 (43%), Gaps = 30/433 (6%) Frame = +3 Query: 330 KWRAQYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHF---PKNDAHPNXXXXXXXXXX 500 +W ++G+ + F G + + D ELV ++ ++ +F +N + Sbjct: 60 EWTKKFGKIYGFTEGTLKTLVISDPELVHEVFVTQYDNFYGRKRNPIQGDSEKEKRTNLF 119 Query: 501 XXXXXDWVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKS 680 W R R + P F+ ++ + +T+ A E+Q++ Q++ K Sbjct: 120 AAQGFRWKRLRAISSPTFSNSSLRKLYQTVEDSALELLRHIEKQSAGGK----QIDMLKF 175 Query: 681 VQELTADIISHTAFGSS----YKLGMEAFYAQKELQAIAISSLLNVQIPGFSYLPTKRNR 848 QE T D+I A G + +K + ++ A L+ P F ++ Sbjct: 176 YQEFTLDVIGRIAMGQTDSQMFKNPIMPIVSKLFQGNFAKLFLIGGIFPTFLVEIIRQIL 235 Query: 849 RKWMLE---KKLRSTLMRIINSRLASQGSGYGN--------DLLGLMLEGCTE-TEQGGK 992 K + +K+ + I++R+ + N D + L L+ E E G+ Sbjct: 236 LKNLKVGSFRKINEITLDAIHNRIKQREEDQKNGIEIGEPADFIDLFLDAKAEDVEHFGE 295 Query: 993 QE----------QLSLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAE 1142 L+ EEI+ +C F AG++TT+L L++ +LL+ +PE Q++L+ E Sbjct: 296 NNGDFSKSTTYTNRQLTTEEIVGQCTVFLIAGFDTTALSLSYATYLLATHPEIQKKLQEE 355 Query: 1143 VLREVGKGDPSGDNLGKLKEMTMVLHETLRLYGPALFM-QRKTTTDMVVGAITIPKEHAI 1319 V RE + + D L KLK M V E LRLY F R+ + +G + + I Sbjct: 356 VNRECPNPEVTIDQLSKLKYMECVFKEALRLYPLGAFANSRRCMRNTKLGNMKVEVGTMI 415 Query: 1320 VIGAPFMHRDKKVWGEDADQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEA 1499 + +H D +WG+DA+ F P R+ + + F +GPR CIG A +E Sbjct: 416 QVDTWTLHTDPNIWGDDAEDFKPERWQTPNSDQIYQKSGYIPFGLGPRQCIGMRLAYMEE 475 Query: 1500 KSVMATVLQKFSF 1538 K ++ +L+KF+F Sbjct: 476 KILLVHILRKFTF 488
>O08336:CYPE_BACSU Probable bifunctional P-450:NADPH-P450 reductase 2 [Includes:| Cytochrome P450 102 - Bacillus subtilis Length = 1054 Score = 128 bits (322), Expect = 7e-29 Identities = 111/371 (29%), Positives = 175/371 (47%), Gaps = 12/371 (3%) Frame = +3 Query: 516 DWVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQELT 695 +W + R++ P+F+ +K M+ A + ++ + N N+EI V D + LT Sbjct: 97 NWQKAHRILLPSFSQKAMKGYHSMMLDIATQ---LIQKWSRLNPNEEIDVADDMT--RLT 151 Query: 696 ADIISHTAFGSSYKLGMEAFYAQKELQAIAISSLLNVQIPGFSYLPTKRNRRKWMLEKKL 875 D I F + +FY ++ Q I+S+L + + K M++ KL Sbjct: 152 LDTIGLCGFNYRFN----SFY--RDSQHPFITSMLRALKEAMNQSKRLGLQDKMMVKTKL 205 Query: 876 R---------STLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGGKQEQLSLSMEEIL 1028 + S + R+I R A+ DLL LML + G+ +L E I Sbjct: 206 QFQKDIEVMNSLVDRMIAERKANPDENI-KDLLSLMLYA--KDPVTGE----TLDDENIR 258 Query: 1029 HECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGKGDPSGDNLGKLKEMT 1208 ++ TF AG+ETTS LL++ ++ L +PE ++ + E R + P + +LK + Sbjct: 259 YQIITFLIAGHETTSGLLSFAIYCLLTHPEKLKKAQEEADRVLTDDTPEYKQIQQLKYIR 318 Query: 1209 MVLHETLRLY--GPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDADQF 1382 MVL+ETLRLY PA + K T ++ G I K + + P +HRD+ WG DA+ F Sbjct: 319 MVLNETLRLYPTAPAFSLYAKEDT-VLGGEYPISKGQPVTVLIPKLHRDQNAWGPDAEDF 377 Query: 1383 NPMRFANGVARAAKVP-HALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSPSYV 1559 P RF + + +P HA F G RACIG FA+ EA V+ VL+ F Y Sbjct: 378 RPERFED----PSSIPHHAYKPFGNGQRACIGMQFALQEATMVLGLVLKHFELINHTGYE 433 Query: 1560 HAPADFLTLRP 1592 + LT++P Sbjct: 434 LKIKEALTIKP 444
>P51870:CP4F5_RAT Cytochrome P450 4F5 - Rattus norvegicus (Rat)| Length = 526 Score = 128 bits (322), Expect = 7e-29 Identities = 108/360 (30%), Positives = 176/360 (48%), Gaps = 22/360 (6%) Frame = +3 Query: 519 WVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQELTA 698 W RHRR++ PAF D +K K ++ + + + +E +++ +T Sbjct: 144 WSRHRRLLTPAFHFDILKPYVKIFNQSVNIMHAKWKHLCLEGSAR---LEMFENISLMTL 200 Query: 699 DIISHTAFG---SSYKLGMEAFYAQKELQAIAISSLLNVQIP-GFSYLPT---KRNRRKW 857 D + FG + + E A EL ++ I + + F Y T +R R+ Sbjct: 201 DSLQKCLFGFDSNCQESPSEYISAILELSSLIIKRSQQLFLYLDFLYYRTADGRRFRKAC 260 Query: 858 MLEKKLRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTET-----------EQGGKQEQL 1004 L ++R L+SQG+ ++ L + ++T ++ GK+ Sbjct: 261 DLVHNFTDAVIRERRRLLSSQGT---DEFLESKTKSKSKTLDFIDVLLLAKDEHGKE--- 314 Query: 1005 SLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEV---LREVGKGDPS 1175 LS E+I E TF F G++TT+ L+W ++ L+ +PE+QER R EV LR+ + Sbjct: 315 -LSDEDIRAEADTFMFGGHDTTASALSWILYNLARHPEYQERCRQEVWELLRDREPEEIE 373 Query: 1176 GDNLGKLKEMTMVLHETLRLYGPALFMQRKTTTDMVV-GAITIPKEHAIVIGAPFMHRDK 1352 D+L +L +TM + E+LRL+ PA+ + R+ T D+V+ IPK + VI +H + Sbjct: 374 WDDLAQLPFLTMCIKESLRLHPPAIDLLRRCTQDIVLPDGRVIPKGNICVISIFGIHHNP 433 Query: 1353 KVWGEDADQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKF 1532 VW D + F+P RF + R + P + + FS GPR CIGQ FAM E K V+A L +F Sbjct: 434 SVW-PDPEVFDPFRF-DSENRQKRSPLSFIPFSAGPRNCIGQTFAMNEMKVVVALTLLRF 491
>P08516:CP4AA_RAT Cytochrome P450 4A10 - Rattus norvegicus (Rat)| Length = 509 Score = 128 bits (322), Expect = 7e-29 Identities = 118/443 (26%), Positives = 202/443 (45%), Gaps = 19/443 (4%) Frame = +3 Query: 354 PFLFWFGAKPRICVFDYELVRQILSSKSGHFPK-NDAHPNXXXXXXXXXXXXXXXDWVRH 530 P FW G+K + V+D + ++ IL PK N + W +H Sbjct: 86 PRWFW-GSKAYLIVYDPDYMKVILGRSD---PKANGVYRLLAPWIGYGLLLLNGQPWFQH 141 Query: 531 RRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQELTADIIS 710 RR++ PAF D +K K M + +E+ A ++++ +E + + +T D + Sbjct: 142 RRMLTPAFHYDILKPYVKNMADSIRLMLDKWEQLAGQDSS----IEIFQHISLMTLDTVM 197 Query: 711 HTAFGSSYKLGMEAFYAQKELQAIA-ISSLLNVQIPG-FSYLPTKRN--------RRKWM 860 AF + + ++ Y + +QAI ++ L + ++ F T N R Sbjct: 198 KCAFSHNGSVQVDGNY-KSYIQAIGNLNDLFHSRVRNIFHQNDTIYNFSSNGHLFNRACQ 256 Query: 861 LEKKLRSTLMRIINSRLASQGS------GYGNDLLGLMLEGCTETEQGGKQEQLSLSMEE 1022 L ++++ +L + G D L ++L E G SLS ++ Sbjct: 257 LAHDHTDGVIKLRKDQLQNAGELEKVKKKRRLDFLDILL--LARMENGD-----SLSDKD 309 Query: 1023 ILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGKGDP-SGDNLGKLK 1199 + E TF F G++TT+ ++W + L+ +PE Q+R R EV +G G + D+L ++ Sbjct: 310 LRAEVDTFMFEGHDTTASGVSWIFYALATHPEHQQRCREEVQSVLGDGSSITWDHLDQIP 369 Query: 1200 EMTMVLHETLRLYGPALFMQRKTTTDMVV-GAITIPKEHAIVIGAPFMHRDKKVWGEDAD 1376 TM + E LRLY P + R+ +T + ++PK + + +H + KVW + + Sbjct: 370 YTTMCIKEALRLYPPVPGIVRELSTSVTFPDGRSLPKGIQVTLSIYGLHHNPKVW-PNPE 428 Query: 1377 QFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSPSY 1556 F+P RFA R + H+ L FS G R CIG+ FAM E K ++A L +F P+ Sbjct: 429 VFDPSRFAPDSPRHS---HSFLPFSGGARNCIGKQFAMSEMKVIVALTLLRFELLPDPTK 485 Query: 1557 VHAPADFLTLRPKFGLPVVMKLL 1625 V P L L+ K G+ + +K L Sbjct: 486 VPIPLPRLVLKSKNGIYLYLKKL 508
>P79401:CP3AT_PIG Cytochrome P450 3A29 - Sus scrofa (Pig)| Length = 503 Score = 128 bits (322), Expect = 7e-29 Identities = 112/421 (26%), Positives = 181/421 (42%), Gaps = 22/421 (5%) Frame = +3 Query: 342 QYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHFPKNDAHPNXXXXXXXXXXXXXXXDW 521 QYG+ + + G +P + V D +++ +L + N +W Sbjct: 67 QYGKMWGVYDGRQPLLAVTDPNMIKSVLVKECYSVFTNRRSFGPLGAMRNALSLAEDEEW 126 Query: 522 VRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQELTAD 701 R R ++ P F K+K M + ++A K ++ F + D Sbjct: 127 KRIRTLLSPTFTSGKLKEMFPIISHYGDLLVSNLRKEAEKGKPVTMKDIFGA----YSMD 182 Query: 702 IISHTAFG---------------SSYKLGMEAFYAQKELQAI------AISSLLNVQIPG 818 +I+ TAFG +S KL +F+ L I I +LN+ + Sbjct: 183 VITSTAFGVNIDSLNNPQDPFVENSKKLLKFSFFDPFLLSLIFFPFLTPIFEVLNITLFP 242 Query: 819 FSYLPTKRNRRKWMLEKKLRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGGKQE 998 S + K M E +L R + DLL LM+ E + Sbjct: 243 KSSVNFFTKSVKRMKESRLTDQQKRRV-------------DLLQLMINSQNSKEMDPHK- 288 Query: 999 QLSLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREV-GKGDPS 1175 SLS EE++ + F FAGYETTS L+ + L+ +P+ Q++L+ E+ K P+ Sbjct: 289 --SLSNEELVAQGIIFIFAGYETTSSALSLLAYELATHPDVQQKLQEEIEATFPNKAPPT 346 Query: 1176 GDNLGKLKEMTMVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKK 1355 D L +++ + MV++ETLRLY A ++R D+ + + +PK +V+ +HRD Sbjct: 347 YDALAQMEYLDMVVNETLRLYPIAARLERACKKDVEIHGVFVPKGTVVVVPVFVLHRDPD 406 Query: 1356 VWGEDADQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFS 1535 +W E ++F P RF+ P+ L F GPR CIG FA++ K + VLQ FS Sbjct: 407 LWPE-PEEFRPERFSKKHKDTIN-PYTYLPFGTGPRNCIGMRFALMNMKLALVRVLQNFS 464 Query: 1536 F 1538 F Sbjct: 465 F 465
>Q27513:C13A4_CAEEL Putative cytochrome P450 CYP13A4 - Caenorhabditis elegans| Length = 520 Score = 128 bits (322), Expect = 7e-29 Identities = 111/449 (24%), Positives = 187/449 (41%), Gaps = 31/449 (6%) Frame = +3 Query: 294 HDYLHRVAPHFLKWRAQYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHFPKNDAHP-- 467 HDY + +W +YG + G + + V + E V ++ + +F +P Sbjct: 47 HDYENPGLLKLGEWTKKYGSIYGITEGVEKTLVVSNPEFVHEVFVKQFDNFYGRKTNPIQ 106 Query: 468 -NXXXXXXXXXXXXXXXDWVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKN 644 + W R R + P F+ ++ + T+ +E ++K Sbjct: 107 GDPNKNKRAHLVLAQGHRWKRLRTLASPTFSNKSLRKIMSTVEETVVELMRHLDEASAKG 166 Query: 645 TNKEIQVEFDKSVQELTADIISHTAFGSSYKLGMEAFYAQKELQAIAISSLLNVQIPGFS 824 V+ QE T DII A G + L K + + I G Sbjct: 167 K----AVDLLDYYQEFTLDIIGRIAMGQTESLMFRNPMLPKVKEIFKKGGKMPFLIAGVF 222 Query: 825 YLPTKRNRRKWMLEKK------LRSTLMRIINSRLASQG---------SGYGNDLLGLML 959 + R+ +M K + +T+ + +N RL + SG D + L L Sbjct: 223 PIAGTLMRQLFMKFPKFSPAFGIMNTMEKALNKRLEQRAADKKAGIEPSGEPQDFIDLFL 282 Query: 960 EGCTETEQGGKQEQLS------------LSMEEILHECKTFFFAGYETTSLLLTWTVFLL 1103 + + ++ L L+ +EI+ + F AGY+TT+L L+++ +LL Sbjct: 283 DARANVDFIEEESTLGFAKSEVLKVDKHLTFDEIIGQLFVFLLAGYDTTALSLSYSSYLL 342 Query: 1104 SVYPEWQERLRAEVLREVGKGDPSGDNLGKLKEMTMVLHETLRLYGPA-LFMQRKTTTDM 1280 + +PE Q++L+ EV RE + + D + KLK M V+ E LR+Y A L RK Sbjct: 343 ATHPEIQKKLQEEVDRECPDPEVTFDQISKLKYMECVVKEALRMYPLASLVHNRKCMKKT 402 Query: 1281 VVGAITIPKEHAIVIGAPFMHRDKKVWGEDADQFNPMRFANGVARAAKVPHALLAFSIGP 1460 V + I + + + +H D KVWG+DA +F P R+ G L F +GP Sbjct: 403 NVLGVEIDEGTNVQVDTWTLHYDPKVWGDDASEFKPERWETG-DELFYAKGGYLPFGMGP 461 Query: 1461 RACIGQNFAMLEAKSVMATVLQKFSFALS 1547 R CIG AM+E K ++ +L+K++F S Sbjct: 462 RICIGMRLAMMEEKLLLTHILKKYTFDTS 490
>P15129:CP4B1_RAT Cytochrome P450 4B1 - Rattus norvegicus (Rat)| Length = 511 Score = 127 bits (319), Expect = 2e-28 Identities = 131/524 (25%), Positives = 217/524 (41%), Gaps = 23/524 (4%) Frame = +3 Query: 123 WAWERLLVRLVWRPYAVARRHRA-----QGIHGPPYRFLRGSNEEVRRMKAETAHVVLHV 287 WA +L+ +V + +++ R + GPP +L G E++++ + Sbjct: 16 WASVVILMVIVLKLFSLLLRRQKLARAMDSFPGPPTHWLFGHALEIQKLGS--------- 66 Query: 288 RDHDYLHRVAPHFLKWRAQYGEPFLFWFGAKPRIC-VFDYELVRQILSSKSGHFPKNDAH 464 L +V + W Q+ WFG +++ + + + S G D + Sbjct: 67 -----LDKV----VSWAQQFPHAHPLWFGQFVGFLNIYEPDYAKAVYSR--GDPKAADVY 115 Query: 465 PNXXXXXXXXXXXXXXXDWVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKN 644 W +HR+++ P F D +K + +E++AS+N Sbjct: 116 DFFLQWIGKGLLVLDGPKWFQHRKLLTPGFHYDVLKPYVAIFAESTRMMLDKWEKKASEN 175 Query: 645 TNKEIQVEFDKSVQELTADIISHTAFGSSYKLGMEAFYAQKELQAIAISSLLNVQIPGFS 824 + +I + V + D + FG G+ L ++ L+ +I F Sbjct: 176 KSFDIFCD----VGHMALDTLMKCTFGKGDS-GLGHRDNSYYLAVSDLTLLMQQRIDSFQ 230 Query: 825 YLP------TKRNRRKWMLEKKLRSTLMRIINSRLASQGSGYGN---------DLLGLML 959 Y T RR K +I R A+ D L ++L Sbjct: 231 YHNDFIYWLTPHGRRFLRACKIAHDHTDEVIRQRKAALQDEKERKKIQQRRHLDFLDILL 290 Query: 960 EGCTETEQGGKQEQLSLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRA 1139 E G + LS E+ E TF F G++TT+ ++W ++ +++YPE Q+ R Sbjct: 291 G--VRDESG-----IKLSDAELRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQQLCRE 343 Query: 1140 EVLREVGKGDP-SGDNLGKLKEMTMVLHETLRLYGPALFMQRKTTTDMV-VGAITIPKEH 1313 EV +G D D+L K+ +TM + E RLY P + R+ + V ++P Sbjct: 344 EVRGILGDQDSFQWDDLAKMTYLTMCMKECFRLYPPVPQVYRQLNKPVTFVDGRSLPAGS 403 Query: 1314 AIVIGAPFMHRDKKVWGEDADQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAML 1493 I + +HR+ VW D + F+P+RF+ A A + P A + FS GPR CIGQ FAM Sbjct: 404 LISLHIYALHRNSTVW-PDPEVFDPLRFSPENA-AGRHPFAFMPFSAGPRNCIGQQFAMN 461 Query: 1494 EAKSVMATVLQKFSFALSPSYVHAPADFLTLRPKFGLPVVMKLL 1625 E K V A L +F F+L PS + L LR K G+ + +K L Sbjct: 462 EMKVVTALCLLRFEFSLDPSKMPIKVPQLILRSKNGIHLYLKPL 505
>Q9WVK8:CP46A_MOUSE Cytochrome P450 46A1 - Mus musculus (Mouse)| Length = 500 Score = 127 bits (319), Expect = 2e-28 Identities = 113/371 (30%), Positives = 174/371 (46%), Gaps = 13/371 (3%) Frame = +3 Query: 519 WVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQELTA 698 W + R+V+D AF+ + ++ +T A+ + E +A T V + T Sbjct: 134 WYKQRKVMDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQT----PVSMQDMLTCATI 189 Query: 699 DIISHTAFG--SSYKLGMEAFYAQKELQAIAISSLLNVQIPGFS--------YLPTKRNR 848 DI++ AFG +S LG AQK L S + V + G S ++P KR + Sbjct: 190 DILAKAAFGMETSMLLG-----AQKPL-----SQAVKVMLEGISASRNTLAKFMPGKRKQ 239 Query: 849 RKWMLE--KKLRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGGKQEQLSLSMEE 1022 + + E + LR + R + G D+ +L + E+G + +++ Sbjct: 240 LREIRESIRLLRQVGKDWVQRR--REALKRGEDMPADILTQILKAEEGAQDDEV------ 291 Query: 1023 ILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVG-KGDPSGDNLGKLK 1199 +L TFF AG+ET++ L +TV LS PE RL+AEV VG K ++LG+L+ Sbjct: 292 LLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVVGSKRHLDYEDLGRLQ 351 Query: 1200 EMTMVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDADQ 1379 ++ VL E+LRLY PA R + ++ + +P ++ M R + ED Sbjct: 352 YLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGR-MDTYFEDPLT 410 Query: 1380 FNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSPSYV 1559 FNP RF G A K FS+G R+CIGQ FA +E K VMA +LQ+ F L P Sbjct: 411 FNPDRFGPG---APKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRIEFRLVPGQR 467 Query: 1560 HAPADFLTLRP 1592 + TL+P Sbjct: 468 FGLQEQATLKP 478
>Q27518:C13A2_CAEEL Putative cytochrome P450 CYP13A2 - Caenorhabditis elegans| Length = 515 Score = 127 bits (319), Expect = 2e-28 Identities = 115/460 (25%), Positives = 199/460 (43%), Gaps = 38/460 (8%) Frame = +3 Query: 330 KWRAQYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHFPKNDAHP---NXXXXXXXXXX 500 +W +YG+ + + G + + V D +V +I + +F +P N Sbjct: 61 EWTKKYGKVYGYTDGTQRTLVVADPAMVHEIFVKQFDNFYGRKLNPIQGNPEKEQRVHLL 120 Query: 501 XXXXXDWVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKS 680 W R R + +F+ +K M +T+ A E+Q + Q++ + Sbjct: 121 AAQGYRWKRLRTISSQSFSNASLKKMKRTVEDSALELLRHIEKQTAGGE----QIDMLRF 176 Query: 681 VQELTADIISHTAFGSSYKLGMEAFYAQKELQAIAISSLLNVQIPGFSYLPTKRNRRKWM 860 QE T D+I A G + + M ++ I S N+ + + P + R Sbjct: 177 YQEYTMDVIGRFAMGQTDSM-MFKNPIVNVVREIFCGSRKNLMLICQVFPPIGQFIRDLT 235 Query: 861 LEK------KLRSTLMRIINSRLASQG------SGYGNDLLGLMLEG-------CTETEQ 983 + KL S + ++ +R+A + SG D + L L+ E + Sbjct: 236 FKFPRIPAFKLYSIMQDVVAARIAQREREKGAESGEPQDFIDLFLDARSDDVDFSAEARE 295 Query: 984 GGKQEQLS----LSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLR 1151 + L LS +E++ +C F G++TT+L L++ +LL+V P+ QE++ E+ R Sbjct: 296 DFSKRNLKITKELSADEVVGQCFLFLIGGFDTTALSLSYVTYLLAVNPKIQEKVIEEIAR 355 Query: 1152 EVGKGDPSGDNLGKLKEMTMVLHETLRLYGPA-LFMQRKTTTDMVVGAITIPKEHAIVIG 1328 E G + + LG+LK M V+ E LRLY A + RK V + I + + Sbjct: 356 EFGTSEVEFEKLGRLKYMDCVIKEALRLYPLASISNSRKCMKTTTVNGVKIEAGVYVQMD 415 Query: 1329 APFMHRDKKVWGEDADQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSV 1508 +H D ++WGED +F P R++ K A L F +GPR CIG A++E K + Sbjct: 416 TWSLHYDPELWGEDVKEFKPERWSTDEPLEHK--GAYLPFGLGPRQCIGMRLAIMEQKIL 473 Query: 1509 MATVLQKFSF----------ALSPSYVHAPAD-FLTLRPK 1595 + +L+ ++F L S +P D F+ LRP+ Sbjct: 474 LTHLLKNYTFETGNKTRIPLKLVGSATTSPEDVFVHLRPR 513
>P33274:CP4F1_RAT Cytochrome P450 4F1 - Rattus norvegicus (Rat)| Length = 524 Score = 126 bits (317), Expect = 3e-28 Identities = 118/422 (27%), Positives = 196/422 (46%), Gaps = 26/422 (6%) Frame = +3 Query: 345 YGEPFLFWFGAK-PRICVFDYELVRQILSSKSGHFPKNDAHPNXXXXXXXXXXXXXXXD- 518 Y + FL W G P I + ++VR IL++ + K+ D Sbjct: 84 YPQGFLMWIGPMVPVITLCHSDIVRSILNASAAVALKDVIFYTILKPWLGDGLLVSAGDK 143 Query: 519 WVRHRRVIDPAFAMDKIK--------------AMTKTMVSCAQSTFGVFEEQA--SKNTN 650 W RHRR++ PAF + +K A K ++S S +FE + + ++ Sbjct: 144 WSRHRRMLTPAFHFNILKPYVKIFNDSTNIMHAKWKRLISEGSSRLDMFEHVSLMTLDSL 203 Query: 651 KEIQVEFDKSVQELTADIISHTAFGSSYKLGMEAFYAQKELQAIAISSLL-NVQIPGFSY 827 ++ FD + QE +++ I+ L + A A++ Q + LL N+ G + Sbjct: 204 QKCVFSFDSNCQEKSSEYIAAI-------LELSALVAKRHQQPLLFMDLLYNLTPDGMRF 256 Query: 828 LPTKRNRRKW---MLEKKLRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGGKQE 998 ++ ++ ++ R+ + ++ L S+ D + ++L T+ E G + Sbjct: 257 HKACNLVHEFTDAVIRERRRTLPDQGLDEFLKSKAKSKTLDFIDVLL--LTKDEDGKE-- 312 Query: 999 QLSLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGKGDP-- 1172 LS E+I E TF F G++TT+ L+W ++ L+ PE+QER R EV + DP Sbjct: 313 ---LSDEDIRAEADTFMFEGHDTTASGLSWILYNLANDPEYQERCRQEVQELLRDRDPEE 369 Query: 1173 -SGDNLGKLKEMTMVLHETLRLYGPALFMQRKTTTDMVV-GAITIPKEHAIVIGAPFMHR 1346 D+L +L +TM + E+LRL+ P + R T D+++ TIPK +I +H Sbjct: 370 IEWDDLAQLPFLTMCIKESLRLHPPVTVISRCCTQDILLPDGRTIPKGIICLISIFGIHH 429 Query: 1347 DKKVWGEDADQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQ 1526 + VW D + +NP RF + + P A + FS GPR CIGQ FAM E K +A L Sbjct: 430 NPSVW-PDPEVYNPFRFDPENIKDSS-PLAFIPFSAGPRNCIGQTFAMSEMKVALALTLL 487 Query: 1527 KF 1532 +F Sbjct: 488 RF 489
>Q64481:CP3AG_MOUSE Cytochrome P450 3A16 - Mus musculus (Mouse)| Length = 504 Score = 126 bits (316), Expect = 4e-28 Identities = 109/409 (26%), Positives = 186/409 (45%), Gaps = 10/409 (2%) Frame = +3 Query: 342 QYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHFPKNDAHPNXXXXXXXXXXXXXXXDW 521 +YG+ + + G P + D E ++ +L + N +W Sbjct: 67 KYGKTWGLFDGQIPLFVITDPETIKNVLVKECFSVFTNRQDFFPVGIMSKSISLAKDEEW 126 Query: 522 VRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQELTAD 701 R+R ++ P F +K M + ++A K K + V+ + + D Sbjct: 127 KRYRALLSPTFTSGNLKEMFPVIEQYGDILVKYLRQEAEKG--KPVAVK--DVLGAYSMD 182 Query: 702 IISHTAFG---SSYKLGMEAFYAQ-KELQAIAISSLLNVQIPGFSYL-PTKRNRRKWMLE 866 +I T FG S + F K++ L++ + F +L P M Sbjct: 183 VIISTTFGVNIDSLNNPEDPFVENAKKVLRFDYFDPLSLSVALFPFLTPIYEMLNICMFP 242 Query: 867 KK----LRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGGKQEQLSLSMEEILHE 1034 K + + R+ +RL S+ + D + LM+E +++ K +LS EI + Sbjct: 243 KDSIEFFKKFVDRMTENRLDSKQK-HRVDFIYLMMEAYNKSKD--KDSHKALSEIEITAQ 299 Query: 1035 CKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREV-GKGDPSGDNLGKLKEMTM 1211 F FAGYETTS +L++TV+ L+ +P+ Q++L+ E+ + K P+ D + ++ + M Sbjct: 300 SIIFIFAGYETTSSILSFTVYSLATHPDIQKKLQEEIDEALPNKAPPTYDTVMAMEYLDM 359 Query: 1212 VLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDADQFNPM 1391 VL+ETLRLY +QR D+ + I IPK ++I + +H D + W E ++F P Sbjct: 360 VLNETLRLYPITNRLQRVCKKDVEINGIYIPKGSTVIIPSYVLHHDPQHWPE-PEEFQPE 418 Query: 1392 RFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSF 1538 RF+ + + P+ L F GPR CIG FA++ K + VLQ FSF Sbjct: 419 RFSK-ENKGSIDPYVYLPFGNGPRNCIGMRFALMNMKLALIKVLQNFSF 466
>Q9JMA7:CP341_MOUSE Cytochrome P450 3A41 - Mus musculus (Mouse)| Length = 504 Score = 126 bits (316), Expect = 4e-28 Identities = 106/409 (25%), Positives = 183/409 (44%), Gaps = 10/409 (2%) Frame = +3 Query: 342 QYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHFPKNDAHPNXXXXXXXXXXXXXXXDW 521 +YG+ + + G P + D E+++ +L + N +W Sbjct: 67 KYGKTWGLFDGQMPLFVITDPEMIKNVLVKECFSVFTNRREFGPVGIMSKAISISKDEEW 126 Query: 522 VRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQELTAD 701 R+R ++ P F K+K M + ++A K V + + D Sbjct: 127 KRYRALLSPTFTSGKLKEMFPVIEQYGDILVKYLMQEAEKGK----PVTMKDVLGAYSID 182 Query: 702 IISHTAFG---SSYKLGMEAFYAQ-KELQAIAISSLLNVQIPGFSYL-PTKRNRRKWMLE 866 +I+ T+FG S + F + K + + L + F +L P M Sbjct: 183 VITSTSFGVNVDSLNNPEDPFVEKAKGILRVDFFDPLVFSVVLFPFLTPVYEMLNICMFP 242 Query: 867 KKLRSTLMRIIN----SRLASQGSGYGNDLLGLMLEGCTETEQGGKQEQLSLSMEEILHE 1034 K + +N SRL S+ + D L LM+ ++ K +LS EI + Sbjct: 243 KDSIEFFKKFVNRMKESRLDSK-QKHRVDFLQLMMNAHNNSKD--KDSHKALSDMEITAQ 299 Query: 1035 CKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREV-GKGDPSGDNLGKLKEMTM 1211 F FAGYETTS L++T++ L+ +P+ Q++L+ E+ + K P+ D + +++ + M Sbjct: 300 SIVFIFAGYETTSSTLSFTLYCLATHPDIQKKLQEEIDETLPNKAPPTYDTVMEMEYLDM 359 Query: 1212 VLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDADQFNPM 1391 VL+ETLRLY ++R D+ + + IPK ++I + +H D + W E ++F P Sbjct: 360 VLNETLRLYPIGNRLERFCKKDVELNGVYIPKGSTVMIPSYALHHDPQHWPE-PEEFQPE 418 Query: 1392 RFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSF 1538 RF+ + + P+ + F IGPR CIG FA + K + V+Q FSF Sbjct: 419 RFSK-ENKGSIDPYLYMPFGIGPRNCIGMRFAFMTMKLALTKVMQNFSF 466
>Q8AXY5:C356_FUNHE Cytochrome P450 3A56 - Fundulus heteroclitus (Killifish) (Mummichog)| Length = 496 Score = 125 bits (315), Expect = 5e-28 Identities = 105/413 (25%), Positives = 196/413 (47%), Gaps = 10/413 (2%) Frame = +3 Query: 336 RAQYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHFPKNDAHPNXXXXXXXXXXXXXXX 515 + +YG+ + + G +P +CV D E+++ +L + F N + + Sbjct: 64 KKKYGKVWGIYDGRQPVLCVTDPEIIKAVLVKECLSFFTNRRNFHLNGPLYDALSVAEDD 123 Query: 516 DWVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQELT 695 W R R V+ P+F ++K M + M + + + +++A K+ +++ F + Sbjct: 124 QWKRIRSVLSPSFTSGRLKEMFEIMKNHSANLIRSMKKKADKDEPLDLKEFFGS----YS 179 Query: 696 ADIISHTAFG---SSYKLGMEAFYAQ-KELQAIAISSLLNVQIPGFSYL-PTKRNRRKWM 860 D+++ TAF S + F K++ + L + + F +L P Sbjct: 180 MDVVTSTAFSVDIDSLNNPSDPFVTNIKKMLKFDFLNPLFLAVAFFPFLGPILEKFELSF 239 Query: 861 LEKKLR----STLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGGKQEQLSLSMEEIL 1028 K + ++L +I ++R ASQ D L LM++ + G Q+ SL+ EIL Sbjct: 240 FPKSVTDFFYASLEKIKSNREASQQKSRV-DFLQLMIDS---QKNSGAQQDKSLTDHEIL 295 Query: 1029 HECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEV-LREVGKGDPSGDNLGKLKEM 1205 + F FAGYET+S LT+ + L+ PE ++L+ E+ K L +++ + Sbjct: 296 SQSMIFIFAGYETSSSSLTFLAYNLATNPEVMKKLQEEIDATFPNKAPVHYQPLMEMEYL 355 Query: 1206 TMVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDADQFN 1385 V++E+LRL+ A ++R + + I IPK+ ++I +HRD ++W E + F Sbjct: 356 DCVINESLRLFPIAARLERVAKAAVEINGIVIPKDMVVMIPTWPLHRDPEIWPE-PEAFK 414 Query: 1386 PMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFAL 1544 P RF+ + P+ + F GPR CIG FA++ K + +LQ++SF++ Sbjct: 415 PERFSK-KNKDNIDPYIYMPFGSGPRNCIGMRFALVLIKLAVVEILQQYSFSV 466
>Q29496:CP3AO_SHEEP Cytochrome P450 3A24 - Ovis aries (Sheep)| Length = 503 Score = 125 bits (314), Expect = 6e-28 Identities = 108/413 (26%), Positives = 193/413 (46%), Gaps = 14/413 (3%) Frame = +3 Query: 342 QYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHFPKNDAHPNXXXXXXXXXXXXXXXDW 521 +YG+ + + G +P + + D ++++ +L + N W Sbjct: 67 KYGKMWGVFEGKQPLLVITDPDVIKTVLVKECYSVFTNRRVFGPMGIMKNAVSVAEDEQW 126 Query: 522 VRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQEL--- 692 R R ++ P F K+K M + G + + +N KE + +++++ Sbjct: 127 KRIRTLLSPTFTSGKLKDMFPII--------GKYGDVLVRNLRKEAEKGKSVNMKDIFGA 178 Query: 693 -TADIISHTAFGSSY-KLG--MEAFYAQ-KELQAIAISSLLNVQIPGFSYL-PTKRNRRK 854 + D+I+ T+FG + LG + F K+L I + + F +L P Sbjct: 179 YSMDVITSTSFGVNIDSLGNPQDPFVENAKKLLRFNILDPFLLSVVLFPFLVPIFEVLNI 238 Query: 855 WMLEKK----LRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGGKQEQLSLSMEE 1022 M K L ++ RI SRL D L LM+ E + +LS +E Sbjct: 239 TMFPKSAVDFLTKSVKRIKESRLKDNQKPRV-DFLQLMINSQNSKETDNHK---ALSDQE 294 Query: 1023 ILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREV-GKGDPSGDNLGKLK 1199 ++ + F FAGYETTS L++ +++L+ +P+ Q++L+ E+ K P+ D L +++ Sbjct: 295 LMAQSVIFIFAGYETTSNTLSFLLYILATHPDVQQKLQEEIDATFPNKAPPTYDVLAQME 354 Query: 1200 EMTMVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDADQ 1379 + MV++ETLR++ A+ + R D+ + ++IPK A+ + +HRD ++W E ++ Sbjct: 355 YLDMVVNETLRMFPIAVRLDRLCKKDVEIHGVSIPKGTAVTVPIFVLHRDPQLWPE-PEE 413 Query: 1380 FNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSF 1538 F P RF+ + P+ L F GPR CIG FA++ K + VLQ FSF Sbjct: 414 FRPERFSKKNKDSIN-PYVYLPFGTGPRNCIGMRFAIMNMKLAIVRVLQNFSF 465
>Q9HCS2:CP4FC_HUMAN Cytochrome P450 4F12 - Homo sapiens (Human)| Length = 524 Score = 125 bits (313), Expect = 8e-28 Identities = 114/422 (27%), Positives = 193/422 (45%), Gaps = 22/422 (5%) Frame = +3 Query: 339 AQYGEPFLFWFGAK-PRICVFDYELVRQILSSKSGHFPKNDAHPNXXXXXXXXXXXXXXX 515 A Y + F W G P I + + +R I ++ + PK++ Sbjct: 82 ATYSQGFTVWLGPIIPFIVLCHPDTIRSITNASAAIAPKDNLFIRFLKPWLGEGILLSGG 141 Query: 516 D-WVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQEL 692 D W RHRR++ PAF + +K+ A ++ AS+ +++ ++ + + + Sbjct: 142 DKWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQHLASEGSSR---LDMFEHISLM 198 Query: 693 TADIISHTAFG-SSYKLGMEAFYAQKELQAIAISSLLN---VQIPGFSYLPTKRNRR--- 851 T D + F S+ + Y L+ A+ + +Q F Y + RR Sbjct: 199 TLDSLQKCIFSFDSHCQERPSEYIATILELSALVEKRSQHILQHMDFLYYLSHDGRRFHR 258 Query: 852 ---------KWMLEKKLRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGGKQEQL 1004 ++ ++ R+ + I+ + D + ++L ++ GK Sbjct: 259 ACRLVHDFTDAVIRERRRTLPTQGIDDFFKDKAKSKTLDFIDVLL---LSKDEDGK---- 311 Query: 1005 SLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGKGDP---S 1175 +LS E+I E TF F G++TT+ L+W ++ L+ +PE+QER R EV + DP Sbjct: 312 ALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDRDPKEIE 371 Query: 1176 GDNLGKLKEMTMVLHETLRLYGPALFMQRKTTTDMVV-GAITIPKEHAIVIGAPFMHRDK 1352 D+L +L +TM + E+LRL+ PA F+ R T D+V+ IPK +I +H + Sbjct: 372 WDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRVIPKGITCLIDIIGVHHNP 431 Query: 1353 KVWGEDADQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKF 1532 VW D + ++P RF ++ + P A + FS GPR CIGQ FAM E K V+A +L F Sbjct: 432 TVW-PDPEVYDPFRFDPENSK-GRSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALMLLHF 489 Query: 1533 SF 1538 F Sbjct: 490 RF 491
>P13584:CP4B1_HUMAN Cytochrome P450 4B1 - Homo sapiens (Human)| Length = 511 Score = 125 bits (313), Expect = 8e-28 Identities = 108/384 (28%), Positives = 175/384 (45%), Gaps = 15/384 (3%) Frame = +3 Query: 519 WVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQELTA 698 W++HR+++ P F D +K + +EE+A + + +I + V + Sbjct: 134 WLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDIFCD----VGHMAL 189 Query: 699 DIISHTAFG----------SSYKLGMEAFYAQKELQAIAISSLLNVQIPG-FSYLPTKRN 845 + + FG SSY L A +L + L++ Q F Y T Sbjct: 190 NTLMKCTFGRGDTGLGHRDSSYYL------AVSDLTLLMQQRLVSFQYHNDFIYWLTPHG 243 Query: 846 RRKWMLEKKLRSTLMRIINSRLAS-QGSGYGNDLLGLMLEGCTETEQGGKQEQ-LSLSME 1019 RR + ++I R A+ Q + + G + E + LS Sbjct: 244 RRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIKLSDA 303 Query: 1020 EILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGKGDP-SGDNLGKL 1196 ++ E TF F G++TT+ ++W ++ +++YPE Q R R EV +G D D+LGK+ Sbjct: 304 DLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDDLGKM 363 Query: 1197 KEMTMVLHETLRLYGPALFMQRKTTTDMV-VGAITIPKEHAIVIGAPFMHRDKKVWGEDA 1373 +TM + E+ RLY P + R+ + + V ++P I + +HR+ VW D Sbjct: 364 TYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVW-PDP 422 Query: 1374 DQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSPS 1553 + F+ +RF+ A + + P A + FS GPR CIGQ FAM E K V A L +F F+L PS Sbjct: 423 EVFDSLRFSTENA-SKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLDPS 481 Query: 1554 YVHAPADFLTLRPKFGLPVVMKLL 1625 + L LR K G + +K L Sbjct: 482 RLPIKMPQLVLRSKNGFHLHLKPL 505
>P14579:CP4A5_RABIT Cytochrome P450 4A5 precursor - Oryctolagus cuniculus (Rabbit)| Length = 511 Score = 125 bits (313), Expect = 8e-28 Identities = 117/493 (23%), Positives = 218/493 (44%), Gaps = 20/493 (4%) Frame = +3 Query: 207 PPYRFLRGSNEEVRRMKAETAHVVLHVRDHDYLHRVAPHFLKWRAQYGEPFLFWFGA-KP 383 PP+ +L G + E + +++ LKW ++ W G K Sbjct: 54 PPFHWLLGHSREFQ------------------MNQELQQILKWVEKFPRACPHWIGGNKV 95 Query: 384 RICVFDYELVRQILSSKSGHFPKN-DAHPNXXXXXXXXXXXXXXXDWVRHRRVIDPAFAM 560 R+ ++D + ++ IL PK+ ++ W +HRR++ PAF Sbjct: 96 RVQLYDPDYMKVILGRSD---PKSRGSYTFVAPWIGYGLLLLNGQPWFQHRRMLTPAFHY 152 Query: 561 DKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQELTADIISHTAFGSSYKL 740 D +K MV Q +E+ S++++ E+ + + +T D I AF + Sbjct: 153 DILKPYVGLMVDSVQIMLDKWEQLVSQDSSLEVF----QDISLMTLDTIMKCAFSYQGSV 208 Query: 741 GMEAFYAQKELQAIA-ISSLLNVQIPG--------FSYLPTKR-NRRKWMLEKKLRSTLM 890 +++ +Q +QA+ +++L+ ++ + P R + R L + ++ Sbjct: 209 QLDSRNSQSYIQAVGDLNNLVFARVRNIFHQSDTIYRLSPEGRLSHRACQLAHEHTDRVI 268 Query: 891 RIINSRLASQGS------GYGNDLLGLMLEGCTETEQGGKQEQLSLSMEEILHECKTFFF 1052 + ++L +G D L ++L + E G SLS +++ E TF F Sbjct: 269 QQRKAQLQQEGELEKVRRKRRLDFLDVLL--FAKMENGS-----SLSDQDLRAEVDTFMF 321 Query: 1053 AGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGKGDP-SGDNLGKLKEMTMVLHETL 1229 G++TT+ ++W + L+ +PE Q R R E+ +G G + ++L ++ TM + E + Sbjct: 322 EGHDTTASGVSWIFYALATHPEHQHRCREEIQGLLGDGASITWEHLDQMPYTTMCIKEAM 381 Query: 1230 RLYGPALFMQRKTTTDMVV-GAITIPKEHAIVIGAPFMHRDKKVWGEDADQFNPMRFANG 1406 RLY P + R ++ + ++PK + + +H + VW + + F+P RF G Sbjct: 382 RLYPPVPAISRDLSSPVTFPDGRSLPKGFTVTLSIYGLHHNPNVW-PNPEVFDPGRFTPG 440 Query: 1407 VARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSPSYVHAPADFLTL 1586 AR + HA L FS G R CIG+ FAM E K +A L +F P+ + P L L Sbjct: 441 SARHS---HAFLPFSGGARNCIGKQFAMNELKVAVALTLVRFELLPDPTRIPKPTARLVL 497 Query: 1587 RPKFGLPVVMKLL 1625 + G+ + ++ L Sbjct: 498 KSNNGIHLRLRKL 510
>O70537:CP3AV_MESAU Cytochrome P450 3A31 - Mesocricetus auratus (Golden hamster)| Length = 501 Score = 125 bits (313), Expect = 8e-28 Identities = 103/409 (25%), Positives = 181/409 (44%), Gaps = 11/409 (2%) Frame = +3 Query: 342 QYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHFPKNDAHPNXXXXXXXXXXXXXXXDW 521 +YG+ + + G +P V D E+++ +L + N +W Sbjct: 67 KYGKIWGLFEGQRPLFTVTDTEMIKNVLVKECYSIFTNRRDFGPVGIMSKAVSISKDEEW 126 Query: 522 VRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKN---TNKEIQVEFDKSVQEL 692 R R ++ P F K+K M + +A K T KE+ + Sbjct: 127 KRIRALLSPTFTSGKLKEMFPIIEQYGDILVKFLRREAEKGNPVTTKEVFGAY------- 179 Query: 693 TADIISHTAFG---SSYKLGMEAFYAQKELQAIAISSLLNVQIPGFSYL-PTKRNRRKWM 860 + D+I+ TAFG S + + ++L L + + F +L P M Sbjct: 180 SMDVITSTAFGVSVDSLNNPKDLLWKGRKLLRFDFFDPLFLSVVLFPFLIPIYEKLNVSM 239 Query: 861 LEKKLRSTLMRIINSRLASQ---GSGYGNDLLGLMLEGCTETEQGGKQEQLSLSMEEILH 1031 K S + ++ ++ + D L LM+ + K +LS EI+ Sbjct: 240 FPKDSISFFRKFVDKTKENRLDYNQKHRVDFLQLMMN----SHDNSKDSHKALSDMEIIA 295 Query: 1032 ECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEV-LREVGKGDPSGDNLGKLKEMT 1208 + F FAGY+TTS L++ ++LL+ +P+ Q++L+ E+ + K PS D + +++ + Sbjct: 296 QSIIFIFAGYDTTSSTLSFALYLLATHPDVQKKLQEEIDIALPNKARPSYDKVMEMEYLD 355 Query: 1209 MVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDADQFNP 1388 MVL+ETLRLY ++R D+ + + +PK +++ +H D + W E ++F P Sbjct: 356 MVLNETLRLYPIGSRLERVCKQDVEMDGVFVPKGSIVMVPVFALHYDPQYWPE-PEKFRP 414 Query: 1389 MRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFS 1535 RF+ + + P+ L F GPR CIG FA++ K + VLQ FS Sbjct: 415 ERFSK-ENKGSIDPYIFLPFGNGPRNCIGMRFALMNMKLALTKVLQNFS 462
>P04800:CP3A1_RAT Cytochrome P450 3A1 - Rattus norvegicus (Rat)| Length = 504 Score = 125 bits (313), Expect = 8e-28 Identities = 106/409 (25%), Positives = 189/409 (46%), Gaps = 10/409 (2%) Frame = +3 Query: 342 QYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHFPKNDAHPNXXXXXXXXXXXXXXXDW 521 +YG+ + + G P + D E+++ +L + N +W Sbjct: 67 KYGKIWGLFDGQMPLFAITDTEMIKNVLVKECFSVFTNRRDFGPVGIMGKAVSVAKDEEW 126 Query: 522 VRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQELTAD 701 R+R ++ P F ++K M + +++A T K + ++ K + D Sbjct: 127 KRYRALLSPTFTSGRLKEMFPIIEQYGDILVKYLKQEAE--TGKPVTMK--KVFGAYSMD 182 Query: 702 IISHTAFG---SSYKLGMEAFYAQ-KELQAIAISSLLNVQIPGFSYL-PTKRNRRKWMLE 866 +I+ T+FG S + F + K+L L + + F +L P M Sbjct: 183 VITSTSFGVNVDSLNNPKDPFVEKTKKLLRFDFFDPLFLSVVLFPFLTPIYEMLNICMFP 242 Query: 867 KK----LRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGGKQEQLSLSMEEILHE 1034 K + + R+ +RL S + D L LM+ +++ K+ +LS EI + Sbjct: 243 KDSIEFFKKFVYRMKETRLDSVQK-HRVDFLQLMMNAHNDSKD--KESHTALSDMEITAQ 299 Query: 1035 CKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREV-GKGDPSGDNLGKLKEMTM 1211 F FAGYE TS L++ + L+ +P+ Q++L+ E+ R + K P+ D + +++ + M Sbjct: 300 SIIFIFAGYEPTSSTLSFVLHSLATHPDTQKKLQEEIDRALPNKAPPTYDTVMEMEYLDM 359 Query: 1212 VLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDADQFNPM 1391 VL+ETLRLY ++R D+ + + +PK ++I + +HRD + W E ++F P Sbjct: 360 VLNETLRLYPIGNRLERVCKKDVEINGVFMPKGSVVMIPSYALHRDPQHWPE-PEEFRPE 418 Query: 1392 RFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSF 1538 RF+ + + P+ L F GPR CIG FA++ K + VLQ FSF Sbjct: 419 RFSK-ENKGSIDPYVYLPFGNGPRNCIGMRFALMNMKLALTKVLQNFSF 466
>Q9PVE8:C330_FUNHE Cytochrome P450 3A30 - Fundulus heteroclitus (Killifish) (Mummichog)| Length = 496 Score = 125 bits (313), Expect = 8e-28 Identities = 104/413 (25%), Positives = 195/413 (47%), Gaps = 10/413 (2%) Frame = +3 Query: 336 RAQYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHFPKNDAHPNXXXXXXXXXXXXXXX 515 + +YG+ + + G +P +CV D E+++ +L + F N + Sbjct: 64 KKKYGKVWGIYDGRQPVLCVTDPEIIKAVLVKECLSFFTNRRNFRLNGPLYDAVSIAEDD 123 Query: 516 DWVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQELT 695 W R R V+ P+F ++K M + M + + + +++A K+ +++ F + Sbjct: 124 QWKRIRSVLSPSFTSGRLKEMFEIMKNHSANLIRSMKKKADKDEPLDLKEFFGS----YS 179 Query: 696 ADIISHTAFG---SSYKLGMEAFYAQ-KELQAIAISSLLNVQIPGFSYL-PTKRNRRKWM 860 D+++ TAF S + F K++ + L + + F +L P Sbjct: 180 MDVVTSTAFSVDIDSLNNPSDPFVTNIKKMLKFDFLNPLFLAVAFFPFLGPILEKFELSF 239 Query: 861 LEKKLR----STLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGGKQEQLSLSMEEIL 1028 K + ++L +I ++R ASQ D L LM++ + G Q+ SL+ EIL Sbjct: 240 FPKSVTDFFYASLEKIKSNREASQQKSRV-DFLQLMIDS---QKNSGAQQDKSLTDHEIL 295 Query: 1029 HECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEV-LREVGKGDPSGDNLGKLKEM 1205 + F FAGYET+S LT+ + L+ PE ++L+ E+ K L +++ + Sbjct: 296 SQSMIFIFAGYETSSSSLTFLAYNLATNPEVMKKLQEEIDATFPNKAPVHYQPLMEMEYL 355 Query: 1206 TMVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDADQFN 1385 V++E+LRL+ A ++R + + + IPK+ ++I +HRD ++W E + F Sbjct: 356 DCVINESLRLFPIAARLERVAKAAVEINGVVIPKDMVVMIPTWPLHRDPEIWPE-PEAFK 414 Query: 1386 PMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFAL 1544 P RF+ + P+ + F GPR CIG FA++ K + +LQ++SF++ Sbjct: 415 PERFSK-KNKDNIDPYIYMPFGSGPRNCIGMRFALVLIKLAVVEILQQYSFSV 466
>Q27519:C13A7_CAEEL Putative cytochrome P450 CYP13A7 - Caenorhabditis elegans| Length = 518 Score = 125 bits (313), Expect = 8e-28 Identities = 117/458 (25%), Positives = 199/458 (43%), Gaps = 37/458 (8%) Frame = +3 Query: 297 DYLHRVAPHFLKWRAQYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHFPKN-----DA 461 +Y + A F +W +YG + G + + + D E V ++ + +F Sbjct: 48 NYENPGALKFSEWTKKYGPVYGITEGVEKTLVISDPEFVHEVFVKQFDNFYGRKLTAIQG 107 Query: 462 HPNXXXXXXXXXXXXXXXDWVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASK 641 PN W R R + P F+ ++ + T+ E+ +++ Sbjct: 108 DPNKNKRVPLVAAQGHR--WKRLRTLASPTFSNKSLRKIMGTVEESVTELVRSLEKASAE 165 Query: 642 NTNKEIQVEFDKSVQELTADIISHTAFGSSYKL--------GMEAFYAQKELQAIAISSL 797 ++ + QE T DII A G L ++ + + IS + Sbjct: 166 GKTLDMLEYY----QEFTMDIIGKMAMGQEKSLMFRNPMLDKVKTIFKEGRNNVFMISGI 221 Query: 798 ---LNVQIPG-FSYLPTKRNRR--KWMLEKKLRSTL-MRIINSRLASQGSGYGNDLLGLM 956 + + + F+ P+ + + +LEK L L R + + + SG D + L Sbjct: 222 FPFVGIALRNIFAKFPSLQMATDIQSILEKALNKRLEQREADEKAGIEPSGEPQDFIDLF 281 Query: 957 LEGCT-------ETEQG-GKQEQLS----LSMEEILHECKTFFFAGYETTSLLLTWTVFL 1100 L+ + E EQ K E L L+ +EI+ + F AGY+TT+L L+++ +L Sbjct: 282 LDARSTVDFFEGEAEQDFAKSEVLKVDKHLTFDEIIGQLFVFLLAGYDTTALSLSYSSYL 341 Query: 1101 LSVYPEWQERLRAEVLREVGKGDPSGDNLGKLKEMTMVLHETLRLYGPA-LFMQRKTTTD 1277 L+ +PE Q++L+ EV RE + + D L KLK + V+ E LRLY A L RK Sbjct: 342 LATHPEIQKKLQEEVDRECPDPEVTFDQLSKLKYLECVVKEALRLYPLASLVHNRKCLKT 401 Query: 1278 MVVGAITIPKEHAIVIGAPFMHRDKKVWGEDADQFNPMRFANG----VARAAKVPHALLA 1445 V + I I + +H D KVWG+D ++F P R+ +G A+ +P Sbjct: 402 TNVLGMEIEAGTNINVDTWSLHHDPKVWGDDVNEFKPERWESGDELFFAKGGYLP----- 456 Query: 1446 FSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSPSYV 1559 F +GPR CIG AM+E K ++ +L+ ++F +P V Sbjct: 457 FGMGPRICIGMRLAMMEMKMLLTNILKNYTFETTPETV 494
>Q86W10:CP4Z1_HUMAN Cytochrome P450 4Z1 - Homo sapiens (Human)| Length = 505 Score = 124 bits (312), Expect = 1e-27 Identities = 97/384 (25%), Positives = 173/384 (45%), Gaps = 17/384 (4%) Frame = +3 Query: 519 WVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQELTA 698 W +HR+++ P F + +K M + +EE ++N+ ++E + V +T Sbjct: 133 WKKHRQIVKPGFNISILKIFITMMSESVRMMLNKWEEHIAQNS----RLELFQHVSLMTL 188 Query: 699 DIISHTAFGSSYKLGMEAFYAQKELQAIAISSLLNVQIPGFSY-------------LPTK 839 D I AF + +++ +S + N ++ F + + +K Sbjct: 189 DSIMKCAFSHQGSIQLDSTLDSYLKAVFNLSKISNQRMNNFLHHNDLVFKFSSQGQIFSK 248 Query: 840 RNRRKWMLEKKLRSTLMRIINSRLASQGSGYGN-DLLGLMLEGCTETEQGGKQEQLSLSM 1016 N+ +K+ + +L + D L ++L +E + S Sbjct: 249 FNQELHQFTEKVIQDRKESLKDKLKQDTTQKRRWDFLDILLSAKSENTK-------DFSE 301 Query: 1017 EEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGKGDP-SGDNLGK 1193 ++ E KTF FAG++TTS ++W ++ L+ YPE Q+R R E+ +G G + ++L + Sbjct: 302 ADLQAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELLGDGSSITWEHLSQ 361 Query: 1194 LKEMTMVLHETLRLYGPALFMQRKTTTDMVV-GAITIPKEHAIVIGAPFMHRDKKVWGED 1370 + TM + E LRLY P + + R + ++P + I +H + W ED Sbjct: 362 MPYTTMCIKECLRLYAPVVNISRLLDKPITFPDGRSLPAGITVFINIWALHHNPYFW-ED 420 Query: 1371 ADQFNPMRFANGVARAAKV-PHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALS 1547 FNP+RF+ + K+ P+A + FS G R CIGQ+FA++E K +A L +F A Sbjct: 421 PQVFNPLRFSR--ENSEKIHPYAFIPFSAGLRNCIGQHFAIIECKVAVALTLLRFKLAPD 478 Query: 1548 PSYVHAPADFLTLRPKFGLPVVMK 1619 S P + L+ K G+ V K Sbjct: 479 HSRPPQPVRQVVLKSKNGIHVFAK 502
>P20815:CP3A5_HUMAN Cytochrome P450 3A5 - Homo sapiens (Human)| Length = 502 Score = 124 bits (312), Expect = 1e-27 Identities = 108/411 (26%), Positives = 185/411 (45%), Gaps = 12/411 (2%) Frame = +3 Query: 342 QYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHFPKNDAHPNXXXXXXXXXXXXXXXDW 521 +YG+ + + G P + + D +++R +L + N +W Sbjct: 67 KYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLAEDEEW 126 Query: 522 VRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQELTAD 701 R R ++ P F K+K M + +A K ++ F + D Sbjct: 127 KRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGA----YSMD 182 Query: 702 IISHTAFG---SSYKLGMEAFY-AQKELQAIAISSLLNVQIPGFSYLPTKRNRRKWMLEK 869 +I+ T+FG S + F + K+ L + I F +L L Sbjct: 183 VITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFP 242 Query: 870 K-----LRSTLMRIINSRLASQGSGYGNDLLGLMLEG--CTETEQGGKQEQLSLSMEEIL 1028 K L ++ R+ SRL + + D L LM++ ETE L L+ + I+ Sbjct: 243 KDTINFLSKSVNRMKKSRLNDKQK-HRLDFLQLMIDSQNSKETESHKALSDLELAAQSII 301 Query: 1029 HECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREV-GKGDPSGDNLGKLKEM 1205 F FAGYETTS +L++T++ L+ +P+ Q++L+ E+ + K P+ D + +++ + Sbjct: 302 -----FIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYL 356 Query: 1206 TMVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDADQFN 1385 MV++ETLRL+ A+ ++R D+ + + IPK +VI +H D K W E ++F Sbjct: 357 DMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTE-PEEFR 415 Query: 1386 PMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSF 1538 P RF+ + + P+ F GPR CIG FA++ K + VLQ FSF Sbjct: 416 PERFSK--KKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSF 464
>Q64459:CP3AB_MOUSE Cytochrome P450 3A11 - Mus musculus (Mouse)| Length = 504 Score = 124 bits (311), Expect = 1e-27 Identities = 107/409 (26%), Positives = 184/409 (44%), Gaps = 10/409 (2%) Frame = +3 Query: 342 QYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHFPKNDAHPNXXXXXXXXXXXXXXXDW 521 +YG+ + + G P + V D E ++ +L + N +W Sbjct: 67 KYGKTWGLFDGQTPLLAVTDPETIKNVLVKECFSVFTNRRDFGPVGIMSKAISISKDDEW 126 Query: 522 VRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQELTAD 701 R+R ++ P F K+K M + ++A K V + + D Sbjct: 127 KRYRALLSPTFTSGKLKEMFPVIEQYGDILVKYLRQKAKKGK----PVTMKDVLGAYSMD 182 Query: 702 IISHTAFG---SSYKLGMEAFYAQ-KELQAIAISSLLNVQIPGFSYL-PTKRNRRKWMLE 866 +I+ T+FG S + F + K+L L + F +L P M Sbjct: 183 VITSTSFGVNVDSLNNPEDPFVEKAKKLLRFDFFDPLLFSVVLFPFLTPVYEMLNICMFP 242 Query: 867 KK----LRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGGKQEQLSLSMEEILHE 1034 K + + R+ SRL S+ + D L LM+ ++ K +LS EI + Sbjct: 243 KDSIEFFKKFVDRMKESRLDSKQK-HRVDFLQLMMNSHNNSKD--KVSHKALSDMEITAQ 299 Query: 1035 CKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREV-GKGDPSGDNLGKLKEMTM 1211 F FAGYETTS L++T+ L+ +P+ Q++L+ E+ + K P+ D + +++ + M Sbjct: 300 SIIFIFAGYETTSSTLSFTLHSLATHPDIQKKLQDEIDEALPNKAPPTYDTVMEMEYLDM 359 Query: 1212 VLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDADQFNPM 1391 VL+ETLRLY A ++R D+ + + IPK ++I + +H D + W E ++F P Sbjct: 360 VLNETLRLYPIANRLERVCKKDVELNGVYIPKGSTVMIPSYALHHDPQHWSE-PEEFQPE 418 Query: 1392 RFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSF 1538 RF+ + + P+ L F GPR C+G FA++ K + ++Q FSF Sbjct: 419 RFSK-ENKGSIDPYVYLPFGNGPRNCLGMRFALMNMKLALTKIMQNFSF 466
>P14779:CPXB_BACME Bifunctional P-450:NADPH-P450 reductase - Bacillus megaterium| Length = 1049 Score = 123 bits (309), Expect = 2e-27 Identities = 109/369 (29%), Positives = 173/369 (46%), Gaps = 9/369 (2%) Frame = +3 Query: 516 DWVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQELT 695 +W + ++ P+F+ +K MV A +E N + +E + + LT Sbjct: 96 NWKKAHNILLPSFSQQAMKGYHAMMVDIAVQLVQKWER-----LNADEHIEVPEDMTRLT 150 Query: 696 ADIISHTAFGSSYKLGMEAFYAQKELQAI-----AISSLLN-VQIPGFSYLPTKRNRRKW 857 D I F + +FY + I A+ +N +Q N+R++ Sbjct: 151 LDTIGLCGFNYRFN----SFYRDQPHPFITSMVRALDEAMNKLQRANPDDPAYDENKRQF 206 Query: 858 MLEKKLRSTLM-RIINSRLASQGSGYGNDLLGLMLEGCTETEQGGKQEQLSLSMEEILHE 1034 + K+ + L+ +II R AS +DLL ML G + E G L E I ++ Sbjct: 207 QEDIKVMNDLVDKIIADRKAS--GEQSDDLLTHMLNG-KDPETGEP-----LDDENIRYQ 258 Query: 1035 CKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGKGDPSGDNLGKLKEMTMV 1214 TF AG+ETTS LL++ ++ L P ++ E R + PS + +LK + MV Sbjct: 259 IITFLIAGHETTSGLLSFALYFLVKNPHVLQKAAEEAARVLVDPVPSYKQVKQLKYVGMV 318 Query: 1215 LHETLRLY--GPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDADQFNP 1388 L+E LRL+ PA + K T ++ G + K +++ P +HRDK +WG+D ++F P Sbjct: 319 LNEALRLWPTAPAFSLYAKEDT-VLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRP 377 Query: 1389 MRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSPSYVHAP 1568 RF N +A HA F G RACIGQ FA+ EA V+ +L+ F F +Y Sbjct: 378 ERFEN---PSAIPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTNYELDI 434 Query: 1569 ADFLTLRPK 1595 + LTL+P+ Sbjct: 435 KETLTLKPE 443
>Q9EP75:CP4FE_MOUSE Cytochrome P450 4F14 - Mus musculus (Mouse)| Length = 524 Score = 123 bits (309), Expect = 2e-27 Identities = 130/499 (26%), Positives = 223/499 (44%), Gaps = 28/499 (5%) Frame = +3 Query: 120 SWAWERLLVRLVWRPYAVARRHR-AQGIHGPPYR-FLRGSNEEVRRMKAETAHVVLHVRD 293 SW R+L+++ YA R +R G PP R +L G HV + Sbjct: 28 SWILARILIQI----YAAYRNYRHLHGFPQPPKRNWLMG-------------HVGMVTPT 70 Query: 294 HDYLHRVAPHFLKWRAQYGEPFLFWFGAK-PRICVFDYELVRQILSSKSGHFPKNDAHPN 470 L + + Y + FL W G P I + ++VR IL++ + K+ + Sbjct: 71 EQGLKELT----RLVGTYPQGFLMWIGPMVPVITLCHSDIVRSILNASAAVALKDVIFYS 126 Query: 471 XXXXXXXXXXXXXXXD-WVRHRRVIDPAFAMDKIKAMTKT--------------MVSCAQ 605 D W RHRR++ PAF + +K K ++S Sbjct: 127 ILKPWLGDGLLVSAGDKWSRHRRMLTPAFHFNILKPYVKIFNDSTNIMHAKWQRLISDGS 186 Query: 606 STFGVFEEQA--SKNTNKEIQVEFDKSVQELTADIISHTAFGSSYKLGMEAFYAQKELQA 779 + +FE + + ++ ++ FD + QE +++ I+ L + A A++ Q Sbjct: 187 ARLDMFEHVSLMTLDSLQKCVFSFDSNCQEKSSEYIAAI-------LELSALVAKRHQQP 239 Query: 780 IAISSLL-NVQIPGFSYLPTKRNRRKW---MLEKKLRSTLMRIINSRLASQGSGYGNDLL 947 + LL N+ G + ++ ++ ++ R+ + ++ L S+ D + Sbjct: 240 LMFMDLLYNLTPDGMRFRKACNVVHEFTDAVIRERHRTLPDQGLDDFLKSKAKSKTLDFI 299 Query: 948 GLMLEGCTETEQGGKQEQLSLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQE 1127 ++L ++ GK+ LS E+I E TF F G++TT+ L+W ++ L+ +PE+QE Sbjct: 300 DVLL---LSKDEDGKE----LSDEDIRAEADTFMFEGHDTTASGLSWILYNLARHPEYQE 352 Query: 1128 RLRAEVLREVGKGDP---SGDNLGKLKEMTMVLHETLRLYGPALFMQRKTTTDMVV-GAI 1295 R R EV + +P D+L +L +TM + E+LRL+ P + R T D+++ Sbjct: 353 RCRQEVQELLRGREPEEIEWDDLAQLPFLTMCIKESLRLHPPVTVISRCCTQDILLPDGR 412 Query: 1296 TIPKEHAIVIGAPFMHRDKKVWGEDADQFNPMRFANGVARAAKVPHALLAFSIGPRACIG 1475 TIPK +I +H + VW D + ++P RF + + P A + FS GPR CIG Sbjct: 413 TIPKGIICLISIFGIHHNPSVW-PDPEVYDPFRFDPENIKDSS-PLAFIPFSAGPRNCIG 470 Query: 1476 QNFAMLEAKSVMATVLQKF 1532 Q FAM E K +A L +F Sbjct: 471 QTFAMSEMKVALALTLLRF 489
>Q9Y6A2:CP46A_HUMAN Cytochrome P450 46A1 - Homo sapiens (Human)| Length = 500 Score = 123 bits (309), Expect = 2e-27 Identities = 104/361 (28%), Positives = 166/361 (45%), Gaps = 3/361 (0%) Frame = +3 Query: 519 WVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQELTA 698 W + RRVID AF+ + ++ +T A+ + E +A T V + Sbjct: 134 WHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQT----PVSMQDMLTYTAM 189 Query: 699 DIISHTAFGSSYKLGMEAFYAQKELQAIAISSLLNVQIPGFSYLPTKRNRRKWMLE--KK 872 DI++ AFG + + A + + + + + +LP KR + + + E + Sbjct: 190 DILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRF 249 Query: 873 LRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGGKQEQLSLSMEEILHECKTFFF 1052 LR + R + G ++ +L + E+G + + E +L TFF Sbjct: 250 LRQVGRDWVQRR--REALKRGEEVPADILTQILKAEEGAQDD------EGLLDNFVTFFI 301 Query: 1053 AGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVG-KGDPSGDNLGKLKEMTMVLHETL 1229 AG+ET++ L +TV LS PE RL+AEV +G K ++LG+L+ ++ VL E+L Sbjct: 302 AGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESL 361 Query: 1230 RLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDADQFNPMRFANGV 1409 RLY PA R + ++ + +P ++ M R + ED FNP RF G Sbjct: 362 RLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGR-MDTYFEDPLTFNPDRFGPG- 419 Query: 1410 ARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSPSYVHAPADFLTLR 1589 A K FS+G R+CIGQ FA +E K VMA +LQ+ F L P + TL+ Sbjct: 420 --APKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQATLK 477 Query: 1590 P 1592 P Sbjct: 478 P 478
>P51869:CP4F4_RAT Cytochrome P450 4F4 - Rattus norvegicus (Rat)| Length = 522 Score = 123 bits (308), Expect = 3e-27 Identities = 114/417 (27%), Positives = 186/417 (44%), Gaps = 19/417 (4%) Frame = +3 Query: 339 AQYGEPFLFWFGA-KPRICVFDYELVRQILSSKSGHFPKNDAHPNXXXXXXXXXXXXXXX 515 A Y + F+ W G P I + +++R +LS+ + K + Sbjct: 82 ATYPQGFMTWLGPILPIITLCHPDVIRSVLSASASVALKEVIFYSFLKPWLGDGLLLSDG 141 Query: 516 D-WVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQEL 692 D W HRR++ PAF + +K K +++ AS + + ++ K++ + Sbjct: 142 DKWSCHRRMLTPAFHFNILKPYVKIFNDSTNIMHAKWQDLASGGSAR---LDMFKNISLM 198 Query: 693 TADIISHTAFG---SSYKLGMEAFYAQKELQAIAISSLLNVQIPGFS-YLPTKRNRRKWM 860 T D + F + + E A EL A+ + + S Y T RR Sbjct: 199 TLDSLQKCVFSFDSNCQEKPSEYISAILELSALVAKRYQQLLLHTDSLYQLTHNGRRFHK 258 Query: 861 LEKKLRSTLMRIINSRLASQGSGYGNDLLGLMLEGCT---------ETEQGGKQEQLSLS 1013 K + + +I R + S + +D+L T ++ GK+ LS Sbjct: 259 ACKLVHNFTDAVIQGRRRALPSQHEDDILKAKARSKTLDFIDVLLLTKDEDGKE----LS 314 Query: 1014 MEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEV---LREVGKGDPSGDN 1184 E+I E TF F G++TT+ L+W ++ L+ +PE+QER R EV LR+ + D+ Sbjct: 315 DEDIRAEADTFMFEGHDTTASGLSWILYNLARHPEYQERCRQEVRELLRDRESTEIEWDD 374 Query: 1185 LGKLKEMTMVLHETLRLYGPALFMQRKTTTDMVV-GAITIPKEHAIVIGAPFMHRDKKVW 1361 L +L +TM + E+LRL+ P + R+ T D+V+ IPK +I H + VW Sbjct: 375 LAQLPFLTMCIKESLRLHPPVTVISRRCTQDIVLPDGRVIPKGVICIINIFATHHNPTVW 434 Query: 1362 GEDADQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKF 1532 D + ++P RF + + P A + FS GPR CIGQ FAM E K +A L +F Sbjct: 435 -PDPEVYDPFRFDPENIK-DRSPLAFIPFSAGPRNCIGQTFAMNEMKVALALTLLRF 489
>Q91WL5:CP4AC_MOUSE Cytochrome P450 4A12 - Mus musculus (Mouse)| Length = 508 Score = 122 bits (305), Expect = 7e-27 Identities = 116/437 (26%), Positives = 196/437 (44%), Gaps = 18/437 (4%) Frame = +3 Query: 369 FGAKPRICVFDYELVRQILSSKSGHFPK-NDAHPNXXXXXXXXXXXXXXXDWVRHRRVID 545 +G+K RI V+D + ++ IL PK N ++ W +HRR++ Sbjct: 89 WGSKVRIQVYDPDYMKLILGRSD---PKANGSYRFLAPWIGRGLLLLDGQTWFQHRRMLT 145 Query: 546 PAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQELTADIISHTAFG 725 PAF D +K T+ M + +E+ +++ EI + + +T D I AF Sbjct: 146 PAFHYDILKPYTEIMADSVRVMLDKWEQIVGQDSTLEIF----RHITLMTLDTIMKCAFS 201 Query: 726 SSYKLGMEAFY-----AQKELQAIAISSLLNVQIPGFSYLPTKRNRRKWMLEKKL-RSTL 887 + ++ Y A ++L + S + N+ N K KL Sbjct: 202 HEGSVQLDRKYKSYIQAVEDLNDLVFSRVRNIFHQNDIIYRVSSNGCKANSACKLAHDHT 261 Query: 888 MRIINSR---------LASQGSGYGNDLLGLMLEGCTETEQGGKQEQLSLSMEEILHECK 1040 ++I SR L D L ++L E GK SLS +++ E Sbjct: 262 DQVIKSRRIQLQDEEELEKLKKKRRLDFLDILLFARMEN---GK----SLSDKDLRAEVD 314 Query: 1041 TFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGKGDP-SGDNLGKLKEMTMVL 1217 TF F G++TT+ ++W + L+ PE Q+R R E+ +G G + ++L K+ TM + Sbjct: 315 TFMFEGHDTTASGISWIFYALATNPEHQQRCRKEIQSLLGDGTSITWNDLDKMPYTTMCI 374 Query: 1218 HETLRLYGPALFMQRKTTTDMVV-GAITIPKEHAIVIGAPFMHRDKKVWGEDADQFNPMR 1394 E LR+Y P + R+ ++ + ++PK +++ +H + VW + + F+P R Sbjct: 375 KEALRIYPPVPSVSRELSSPVTFPDGRSLPKGIHVMLSFYGLHHNPTVW-PNPEVFDPSR 433 Query: 1395 FANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSPSYVHAPAD 1574 FA G +R + H+ L FS G R CIG+ FAM E K +A L +F P+ V P Sbjct: 434 FAPGSSRHS---HSFLPFSGGARNCIGKQFAMNELKVAVALTLLRFELLPDPTRVPIPIP 490 Query: 1575 FLTLRPKFGLPVVMKLL 1625 + L+ K G+ + +K L Sbjct: 491 RIVLKSKNGIHLHLKKL 507
>Q9VA27:CP4C3_DROME Cytochrome P450 4c3 - Drosophila melanogaster (Fruit fly)| Length = 535 Score = 121 bits (304), Expect = 9e-27 Identities = 132/472 (27%), Positives = 206/472 (43%), Gaps = 32/472 (6%) Frame = +3 Query: 291 DHDYL-HRVAPHFLKWRAQYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHFPKNDAHP 467 DHD L +RV W + G + W G PR+ +F+ E V IL+S+ N +H Sbjct: 76 DHDELFNRVIGMQKLWGTRIGINRV-WQGTAPRVLLFEPETVEPILNSQKF---VNKSHD 131 Query: 468 NXXXXXXXXXXXXXXXD--WVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASK 641 D W R+++ PAF + VF EQ++ Sbjct: 132 YDYLHPWLGEGLLTSTDRKWHSRRKILTPAFHFKIL-----------DDFIDVFNEQSAV 180 Query: 642 NTNKEIQVEFDKSVQEL-------TADIISHTAFG---------------SSYKLG--ME 749 K + VE L T DI+ TA G + Y +G ++ Sbjct: 181 LARK-LAVEVGSEAFNLFPYVTLCTLDIVCETAMGRRIYAQSNSESEYVKAVYGIGSIVQ 239 Query: 750 AFYAQKELQAIAISSLLNVQIPGFSYLPTKRNRRKWML-EKKLRSTLMRIINSRLASQGS 926 + A+ LQ+ I SL SY+ T ++ E+K +++ N+ + Sbjct: 240 SRQAKIWLQSDFIFSLTAEYKLHQSYINTLHGFSNMVIRERKAELAILQENNNNNNNNAP 299 Query: 927 GYGNDLLGLMLEGCTETEQGGKQEQLSLSMEEILHECKTFFFAGYETTSLLLTWTVFLLS 1106 +D+ + +E LS E+I E TF F G++TTS ++WT+FLL Sbjct: 300 DAYDDVGKKKRLAFLDLLIDASKEGTVLSNEDIREEVDTFMFEGHDTTSAAISWTLFLLG 359 Query: 1107 VYPEWQERLRAEVLREVG--KGDPSG-DNLGKLKEMTMVLHETLRLYGPALFMQRKTTTD 1277 +PE+QER+ E+ G K P+ NL ++ + + ++LRL+ M R D Sbjct: 360 CHPEYQERVVEELDSIFGDDKETPATMKNLMDMRYLECCIKDSLRLFPSVPMMARMVGED 419 Query: 1278 MVVGAITIPKEHAIVIGAPFMHRDKKVWGEDADQFNPMRFANGVARAAKVPHALLAFSIG 1457 + +G +P +I +HR+ +V+ + +QFNP F A + P A + FS G Sbjct: 420 VNIGGKIVPAGTQAIIMTYALHRNPRVFPK-PEQFNPDNFLPENC-AGRHPFAYIPFSAG 477 Query: 1458 PRACIGQNFAMLEAKSVMATVLQKFSF-ALSPSYVHAPADFLTLRPKFGLPV 1610 PR CIGQ FA+LE K+V++TVL+K+ A+ L LRPK GL V Sbjct: 478 PRNCIGQKFAILEEKAVISTVLRKYKIEAVDRREDLTLLGELILRPKDGLRV 529
>P15128:CP4B1_RABIT Cytochrome P450 4B1 - Oryctolagus cuniculus (Rabbit)| Length = 506 Score = 121 bits (304), Expect = 9e-27 Identities = 105/385 (27%), Positives = 176/385 (45%), Gaps = 16/385 (4%) Frame = +3 Query: 519 WVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQELTA 698 W +HR+++ P F D +K + +E++A + + +I + V + Sbjct: 129 WFQHRKLLTPGFHYDVLKPYVAIFADSTRIMLEKWEKKACEGKSFDIFSD----VGHMAL 184 Query: 699 DIISHTAFG---SSYKLGMEAFY-AQKELQAIAISSLLNVQIPG-FSYLPTKRNRRKWML 863 D + FG S ++Y A EL + + + Q F Y T RR Sbjct: 185 DTLMKCTFGKGDSGLNHRDSSYYVAVSELTLLMQQRIDSFQYHNDFIYWLTPHGRRFLRA 244 Query: 864 EKKLRSTLMRIINSRLASQGSGYGN---------DLLGLMLEGCTETEQGGKQEQLSLSM 1016 + R+I R A+ D L ++L+ E G + LS Sbjct: 245 CRAAHDHTDRVIRQRKAALQDEKEREKIQNRRHLDFLDILLD--VRGESG-----VQLSD 297 Query: 1017 EEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGKGDP-SGDNLGK 1193 ++ E TF F G++TT+ ++W ++ +++YPE Q+R R EV +G D ++L K Sbjct: 298 TDLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQQRCREEVREILGDQDSFQWEDLAK 357 Query: 1194 LKEMTMVLHETLRLYGPALFMQRKTTTDM-VVGAITIPKEHAIVIGAPFMHRDKKVWGED 1370 + +TM + E RLY P + R+ + + V ++P I + +HR+ VW D Sbjct: 358 MTYLTMCMKECFRLYPPVPQVYRQLSKPVSFVDGRSLPAGSLISLHIYALHRNSDVW-PD 416 Query: 1371 ADQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSP 1550 + F+P+RF+ + + + P+A + FS GPR CIGQ FAM E K V A L +F F++ P Sbjct: 417 PEVFDPLRFSPENS-SGRHPYAFIPFSAGPRNCIGQQFAMNEMKVVTALCLLRFEFSVDP 475 Query: 1551 SYVHAPADFLTLRPKFGLPVVMKLL 1625 + L LR K G+ + +K L Sbjct: 476 LRLPIKLPQLVLRSKNGIHLYLKPL 500
>P08684:CP3A4_HUMAN Cytochrome P450 3A4 - Homo sapiens (Human)| Length = 503 Score = 121 bits (303), Expect = 1e-26 Identities = 104/413 (25%), Positives = 194/413 (46%), Gaps = 14/413 (3%) Frame = +3 Query: 342 QYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHFPKNDAHPNXXXXXXXXXXXXXXXDW 521 +YG+ + F+ G +P + + D ++++ +L + N +W Sbjct: 67 KYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEEW 126 Query: 522 VRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQEL--- 692 R R ++ P F K+K M + + + +N +E + +++++ Sbjct: 127 KRLRSLLSPTFTSGKLKEMVPIIAQ--------YGDVLVRNLRREAETGKPVTLKDVFGA 178 Query: 693 -TADIISHTAFG---SSYKLGMEAFYAQ-KELQAIAISSLLNVQIPGFSYL-PTKRNRRK 854 + D+I+ T+FG S + F K+L + I F +L P Sbjct: 179 YSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNI 238 Query: 855 WMLEKK----LRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGGKQEQLSLSMEE 1022 + ++ LR ++ R+ SRL + D L LM++ E + +LS E Sbjct: 239 CVFPREVTNFLRKSVKRMKESRLEDTQK-HRVDFLQLMIDSQNSKET---ESHKALSDLE 294 Query: 1023 ILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREV-GKGDPSGDNLGKLK 1199 ++ + F FAGYETTS +L++ ++ L+ +P+ Q++L+ E+ + K P+ D + +++ Sbjct: 295 LVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQME 354 Query: 1200 EMTMVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDADQ 1379 + MV++ETLRL+ A+ ++R D+ + + IPK ++I + +HRD K W E ++ Sbjct: 355 YLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTE-PEK 413 Query: 1380 FNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSF 1538 F P RF+ + P+ F GPR CIG FA++ K + VLQ FSF Sbjct: 414 FLPERFSK-KNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSF 465
>P05183:CP3A2_RAT Cytochrome P450 3A2 - Rattus norvegicus (Rat)| Length = 504 Score = 121 bits (303), Expect = 1e-26 Identities = 106/409 (25%), Positives = 188/409 (45%), Gaps = 10/409 (2%) Frame = +3 Query: 342 QYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHFPKNDAHPNXXXXXXXXXXXXXXXDW 521 +YG+ + + G P + D E+++ +L + N +W Sbjct: 67 KYGKIWGLFDGQTPVFAIMDTEMIKNVLVKECFSVFTNRRDFGPVGIMGKAVSVAKDEEW 126 Query: 522 VRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQELTAD 701 R+R ++ P F ++K M + +++A T K + ++ K + D Sbjct: 127 KRYRALLSPTFTSGRLKEMFPIIEQYGDILVKYLKQEAE--TGKPVTMK--KVFGAYSMD 182 Query: 702 IISHTAFG---SSYKLGMEAFYAQ-KELQAIAISSLLNVQIPGFSYL-PTKRNRRKWMLE 866 +I+ T+FG S + F + K+L L + + F +L P M Sbjct: 183 VITSTSFGVNVDSLNNPKDPFVEKTKKLLRFDFFDPLFLSVVLFPFLTPIYEMLNICMFP 242 Query: 867 KK----LRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGGKQEQLSLSMEEILHE 1034 K + + RI +RL S+ + D L LML ++ + +LS EI+ + Sbjct: 243 KDSIAFFQKFVHRIKETRLDSKHK-HRVDFLQLMLNAHNNSKD--EVSHKALSDVEIIAQ 299 Query: 1035 CKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREV-GKGDPSGDNLGKLKEMTM 1211 F FAGYETTS L++ ++ L+ +P+ Q++L+ E+ + K P+ D + +++ + M Sbjct: 300 SVIFIFAGYETTSSTLSFVLYFLATHPDIQKKLQEEIDGALPSKAPPTYDIVMEMEYLDM 359 Query: 1212 VLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDADQFNPM 1391 VL+ETLRLY ++R D+ + + IPK + I +H D + W + ++F+P Sbjct: 360 VLNETLRLYPIGNRLERVCKKDIELDGLFIPKGSVVTIPTYALHHDPQHWPK-PEEFHPE 418 Query: 1392 RFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSF 1538 RF+ + + P+ L F GPR CIG FA++ K + VLQ FSF Sbjct: 419 RFSK-ENKGSIDPYVYLPFGNGPRNCIGMRFALMNMKLALTKVLQNFSF 466
>Q64462:CP4B1_MOUSE Cytochrome P450 4B1 - Mus musculus (Mouse)| Length = 511 Score = 120 bits (302), Expect = 2e-26 Identities = 104/387 (26%), Positives = 171/387 (44%), Gaps = 18/387 (4%) Frame = +3 Query: 519 WVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQELTA 698 W +HR+++ P F D +K + +E++AS+N + +I + V + Sbjct: 134 WFQHRKLLTPGFHYDVLKPYVAIFAESTRVMLDKWEKKASENKSFDIFCD----VGHMAL 189 Query: 699 DIISHTAFGSSYKLGMEAFYAQKELQAIAISSLLNVQIPGFSYLP------TKRNRRKWM 860 D + FG G+ L ++ L+ +I F Y T RR Sbjct: 190 DTLMKCTFGKGDS-GLSHSDNSYYLAVSDLTLLMQQRIDSFQYHNDFIYWLTPHGRRFLR 248 Query: 861 LEKKLRSTLMRIINSRLASQGSGYGN---------DLLGLMLEGCTETEQGGKQEQ-LSL 1010 + +I R A+ D L ++L G + E + L Sbjct: 249 ACQIAHDHTDHVIRQRKAALQDEKEQKKLQERRHLDFLDILL--------GARDESGIKL 300 Query: 1011 SMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGKGDP-SGDNL 1187 S ++ E TF F G++TT+ ++W ++ +++YP Q+R R EV +G D D+L Sbjct: 301 SDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPMHQQRCREEVREILGDRDSFQWDDL 360 Query: 1188 GKLKEMTMVLHETLRLYGPALFMQRKTTTDMV-VGAITIPKEHAIVIGAPFMHRDKKVWG 1364 ++ +TM + E RLY P + R+ + + V ++P I + +HR+ VW Sbjct: 361 AQMTYLTMCMKECFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISLHIYALHRNSAVW- 419 Query: 1365 EDADQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFAL 1544 D + F+P+RF+ + P A + FS GPR CIGQ FAM E K V A L +F F+ Sbjct: 420 PDPEVFDPLRFSPE-NMTGRHPFAFMPFSAGPRNCIGQQFAMNEMKVVTALCLLRFEFSP 478 Query: 1545 SPSYVHAPADFLTLRPKFGLPVVMKLL 1625 PS + L LR K G+ + +K L Sbjct: 479 DPSKIPIKVPQLILRSKNGIHLYLKPL 505
>O17624:C13B1_CAEEL Putative cytochrome P450 cyp-13B1 - Caenorhabditis elegans| Length = 527 Score = 120 bits (302), Expect = 2e-26 Identities = 105/428 (24%), Positives = 182/428 (42%), Gaps = 27/428 (6%) Frame = +3 Query: 330 KWRAQYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHF----PKNDAHPNXXXXXXXXX 497 KW ++G+ F ++ GA P + V D ++++++ K +F N H N Sbjct: 58 KWTQKFGKVFGYYEGAVPVLVVSDMDMLQELFLKKFDNFYARKSTNHIHGNLECSKSEPR 117 Query: 498 XXXXXXD---WVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVE 668 W R R + P F++ +K + M S + + A K + Sbjct: 118 INLFTSRGARWKRLRALASPGFSVKALKQVHDVM---EDSAINMVDLMAKHEDGKPFNIH 174 Query: 669 FDKSVQELTADIISHTAFGSSYK-----LGMEAFYAQKELQAIAISSLLNVQIPGFSYLP 833 QE T D+IS A G G+E + + V P F +L Sbjct: 175 --AYFQEFTYDVISRLAMGQPNSELFNNSGVEIVKSIFMRTHRVLPWYFTVLFPQFEHLV 232 Query: 834 TKRNRRKWMLE----KKLRSTLMRIINSRLASQGSGYG-------NDLLGLMLEGCTETE 980 + ++ +KL + + SR+ + ND + + L +E Sbjct: 233 KRMFYNHAAVQGGDIEKLLLICKKTVESRIQEREENAKLGFENAENDFIDMFLNYYSEQV 292 Query: 981 QG---GKQEQLSLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLR 1151 + G + ++ E+++ C F AG++TT+ L + +LL+ +PE + + EV Sbjct: 293 EDIEFGSTVEKKVTAEDVIGACFVFLLAGFDTTANSLAYASYLLAKHPEKMKLAQEEVDT 352 Query: 1152 EVGKGDPSGDNLGKLKEMTMVLHETLRLYGPALF-MQRKTTTDMVVGAITIPKEHAIVIG 1328 VG + S D++ KLK + V+ E+LRLY A F R+ +G I I K I Sbjct: 353 VVGSENVSYDDMTKLKYLDAVVRESLRLYPVAWFACSRECVKPTTLGDIYIDKGVKIEAD 412 Query: 1329 APFMHRDKKVWGEDADQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSV 1508 +HR K++WGE+AD F P R+ +R + + F GPR C+G + EAK+ Sbjct: 413 VMSLHRSKEIWGENADDFVPERWLEPSSRHTM---SWIPFGAGPRQCVGMRLGLSEAKTA 469 Query: 1509 MATVLQKF 1532 +A +L+++ Sbjct: 470 LAHLLRRY 477
>Q8K4D6:CP4X1_RAT Cytochrome P450 4X1 - Rattus norvegicus (Rat)| Length = 507 Score = 120 bits (301), Expect = 2e-26 Identities = 99/384 (25%), Positives = 173/384 (45%), Gaps = 15/384 (3%) Frame = +3 Query: 519 WVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQELTA 698 W +HR ++ PAF D +K M A S + ++ T +E +E + + +T Sbjct: 133 WFQHRCLLTPAFHQDILKPCVDMM---AHSVNMMLDKWEKTWTTQETTIEVFEHINLMTL 189 Query: 699 DIISHTAFGSSYKLGMEAFYAQKELQAIAISSLLNVQIPGF------SYLPTKRNRRKWM 860 DII AFG + Y + +++ ++ F + + + Sbjct: 190 DIIMKCAFGQETNCQINGTYESYVKATFELGEIISSRLYNFWHHHDIIFKLSPKGHCFQE 249 Query: 861 LEKKLRSTLMRIINSRLASQGSGYGND-------LLGLMLEGCTETEQGGKQEQLSLSME 1019 L K + +II R + D L ++L Q G ++ + S Sbjct: 250 LGKVIHQCTEKIIQDRKKTLKDQVNQDDTQTSQNFLDIVLSA-----QAGDEK--AFSDA 302 Query: 1020 EILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGKGDP-SGDNLGKL 1196 ++ E TF +AG++ ++ ++W ++ L++ PE Q+R R E+ +G G + + L ++ Sbjct: 303 DLRSEVNTFMWAGHDASAASISWLLYCLALNPEHQDRCRTEIRSILGDGSSITWEQLDEI 362 Query: 1197 KEMTMVLHETLRLYGPALFMQRKTTTDMVV-GAITIPKEHAIVIGAPFMHRDKKVWGEDA 1373 TM + ETLRL P + R+ + + + ++P +V+ +H + VW +D Sbjct: 363 PYTTMCIKETLRLIPPIPSISRELSKPLTLPDGHSLPAGMTVVLSIWGLHHNPAVW-KDP 421 Query: 1374 DQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSPS 1553 F+P+RF + + P A L FS GPR CIGQ FAMLE K +A L +F A + Sbjct: 422 KVFDPLRFTKENSEQ-RHPCAFLPFSSGPRNCIGQQFAMLELKVAIALTLLRFRVAADLT 480 Query: 1554 YVHAPADFLTLRPKFGLPVVMKLL 1625 A + LRPK G+ + +K L Sbjct: 481 RPPAFSSHTVLRPKHGIYLHLKKL 504
>Q9V4T5:CP4E1_DROME Probable cytochrome P450 4e1 - Drosophila melanogaster (Fruit fly)| Length = 531 Score = 120 bits (301), Expect = 2e-26 Identities = 110/422 (26%), Positives = 185/422 (43%), Gaps = 19/422 (4%) Frame = +3 Query: 324 FLKWRAQYGEP-FLFWFGAKPRICVFDYELVRQILSSKSGHFPKNDAHPNXXXXXXXXXX 500 F W +YG+ F +W G I V + + + ILSS++ K+D + Sbjct: 59 FFGWWHEYGKDNFRYWIGYYSNIMVTNPKYMEFILSSQT-LISKSDVYDLTHPWLGLGLL 117 Query: 501 XXXXXDWVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKS 680 W +HR++I PAF + ++ + M + F +Q K + +F + Sbjct: 118 TSTGSKWHKHRKMITPAFHFNILQDFHEVMNENSTK----FIDQLKKVADGGNIFDFQEE 173 Query: 681 VQELTADIISHTAFGSSYKLGMEAFYAQKELQAIAISSLLNVQIPGFSYLPTKRNRRKWM 860 LT D+I TA G S ME + + + I ++ P KRN+ + Sbjct: 174 AHYLTLDVICDTAMGVSIN-AME----NRSSSVVQAFKDITYTIKMRAFSPWKRNKYLFH 228 Query: 861 LE----------KKLRSTLMRIINSRLASQGSGYG----NDLLGLMLEGCTETEQGGKQE 998 K L+ II R+ + SG D +T K + Sbjct: 229 FAPEYPEYSKTLKTLQDFTNEIIAKRIEVRKSGLEVGIKADEFSRKKMAFLDTLLSSKVD 288 Query: 999 QLSLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERL---RAEVLREVGKG- 1166 L+ +E+ E TF F G++TT+ + + V+LLS +P+ QE+L + +V+ G G Sbjct: 289 GRPLTSQELYEEVSTFMFEGHDTTTSGVGFAVYLLSRHPDEQEKLFNEQCDVMGASGLGR 348 Query: 1167 DPSGDNLGKLKEMTMVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHR 1346 D + + +K + + + E RLY F+ R T D V+ +PK + +G + Sbjct: 349 DATFQEISTMKHLDLFIKEAQRLYPSVPFIGRFTEKDYVIDGDIVPKGTTLNLGLLMLGY 408 Query: 1347 DKKVWGEDADQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQ 1526 + +V+ +D +F P RF R P + FS GPR CIGQ FA+LE K+V++ +++ Sbjct: 409 NDRVF-KDPHKFQPERFD----REKPGPFEYVPFSAGPRNCIGQKFALLEIKTVVSKIIR 463 Query: 1527 KF 1532 F Sbjct: 464 NF 465
>Q8SPK1:CP4AO_PIG Cytochrome P450 4A24 - Sus scrofa (Pig)| Length = 504 Score = 120 bits (301), Expect = 2e-26 Identities = 120/460 (26%), Positives = 201/460 (43%), Gaps = 24/460 (5%) Frame = +3 Query: 318 PHFLKWRAQYGEPFLFW-FGAKPRICVFDYELVRQILSSKSGHFPKNDA-HPNXXXXXXX 491 P LK +Y W +G + + V+D + ++ +L+ PKN + Sbjct: 67 PPLLKRVEKYPSACALWRWGTRAMVLVYDPDYMKVVLARSD---PKNSVVYRLLIPWIGC 123 Query: 492 XXXXXXXXDWVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEF 671 W + RR++ PAF D +K M Q +E+ +++ EI Sbjct: 124 GLLLLNGQTWFQRRRMLTPAFHYDILKPYVGLMAKSVQVMLDKWEQLVAQDPRLEIV--- 180 Query: 672 DKSVQELTADIISHTAF---GSSYKLG-----MEAFYAQKELQAIAISSLLNVQIPGFSY 827 V +T D I AF GS+ G ++A + K L +I S + Sbjct: 181 -GPVSLMTLDTIMKCAFSHQGSAQTDGDSHSYIQAIWDLKNLFSIRTKSAFLQNDIIYRL 239 Query: 828 LPT-KRNRRKWMLEKKLRSTLMRIINSRLASQGSGYGN------DLLGLMLEGCTETEQG 986 P ++N R + + ++++ ++L QG D L ++L E+G Sbjct: 240 SPEGRKNHRAARIAHQHTDRVIQLRKAQLQKQGEMENVRKKRHLDFLDILL--LARMEKG 297 Query: 987 GKQEQLSLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGKG 1166 SLS ++ E TF F G++TT+ ++W ++ L+ +PE Q+R R E+ +G G Sbjct: 298 N-----SLSDTDLRAEVDTFMFEGHDTTASGISWILYALASHPEHQQRCREEIQGLLGDG 352 Query: 1167 DP-SGDNLGKLKEMTMVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPF-- 1337 + D+L ++ TM + E LRLY P + R+ + IT P ++ G Sbjct: 353 TSITWDHLDQMPYTTMCIKEALRLYPPVPGVSRELSK-----PITFPDGRSLPAGITLSL 407 Query: 1338 ----MHRDKKVWGEDADQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKS 1505 +H + +VW + ++F+P RFA G AR + HA + FS G R CIG+ FAM E K Sbjct: 408 SIYGLHHNPQVW-PNPEEFDPSRFAPGSARHS---HAFMPFSGGSRNCIGKQFAMNEMKV 463 Query: 1506 VMATVLQKFSFALSPSYVHAPADFLTLRPKFGLPVVMKLL 1625 +A L +F A PS + L K G+ + ++ L Sbjct: 464 AVALTLLRFELAPDPSRKPIATPEVVLNSKNGIHLKLRKL 503
>P10611:CP4A4_RABIT Cytochrome P450 4A4 precursor - Oryctolagus cuniculus (Rabbit)| Length = 510 Score = 120 bits (301), Expect = 2e-26 Identities = 118/450 (26%), Positives = 196/450 (43%), Gaps = 18/450 (4%) Frame = +3 Query: 330 KWRAQYGEPFLFWF-GAKPRICVFDYELVRQILSSKSGHFPKNDAHPNXXXXXXXXXXXX 506 KW ++ +W G K R+ V+D + ++ IL P+N + Sbjct: 77 KWVEKFPGACPWWLSGNKARLLVYDPDYLKVILGRSDPKAPRN--YKLMTPWIGYGLLLL 134 Query: 507 XXXDWVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQ 686 W +HRR++ PAF D +K MV Q +E+ S++++ EI + V Sbjct: 135 DGQTWFQHRRMLTPAFHYDILKPYVGLMVDSVQIMLDRWEQLISQDSSLEIF----QHVS 190 Query: 687 ELTADIISHTAFGSSYKLGMEA-----FYAQKELQAIAISSLLNV-QIPGFSYLPTKRNR 848 +T D I AF + ++ A +L + NV F Y + R Sbjct: 191 LMTLDTIMKCAFSYQGSVQLDRNSHSYIQAINDLNNLVFYRARNVFHQSDFLYRLSPEGR 250 Query: 849 RKWMLEKKLRSTLMRIINSRLAS-QGSGYGN--------DLLGLMLEGCTETEQGGKQEQ 1001 + R+I R A Q G D L ++L + E G Sbjct: 251 LFHRACQLAHEHTDRVIQQRKAQLQQEGELEKVRRKRRLDFLDVLL--FAKMENGS---- 304 Query: 1002 LSLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGKGDP-SG 1178 SLS +++ E TF F G++TT+ ++W + L+ +PE Q R R E+ +G G + Sbjct: 305 -SLSDQDLRAEVDTFMFEGHDTTASGVSWIFYALATHPEHQHRCREEIQGLLGDGASITW 363 Query: 1179 DNLGKLKEMTMVLHETLRLYGPALFMQRKTTTDMVV-GAITIPKEHAIVIGAPFMHRDKK 1355 ++L ++ TM + E LRLY P + R+ + + ++PK + + +H + K Sbjct: 364 EHLDQMPYTTMCIKEALRLYPPVPSVTRQLSKPVTFPDGRSLPKGVILFLSIYGLHYNPK 423 Query: 1356 VWGEDADQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFS 1535 VW ++ + F+P RFA A + HA L FS G R CIG+ FAM E K +A L +F Sbjct: 424 VW-QNPEVFDPFRFAPDSAYHS---HAFLPFSGGARNCIGKQFAMRELKVAVALTLVRFE 479 Query: 1536 FALSPSYVHAPADFLTLRPKFGLPVVMKLL 1625 P+ + P + L+ K G+ + ++ L Sbjct: 480 LLPDPTRIPIPIARVVLKSKNGIHLRLRKL 509
>Q6NT55:CP4FN_HUMAN Cytochrome P450 4F22 - Homo sapiens (Human)| Length = 531 Score = 120 bits (300), Expect = 3e-26 Identities = 121/438 (27%), Positives = 195/438 (44%), Gaps = 23/438 (5%) Frame = +3 Query: 360 LFWFG-AKPRICVFDYELVRQILSSKSGHFPKNDAHPNXXXXXXXXXXXXXXXD-WVRHR 533 L W G P + + + ++ +L + + PK+D D W RHR Sbjct: 97 LVWMGPVLPLLVLVHPDYIKPLLGASAAIAPKDDLFYGFLKPWLGDGLLLSKGDKWSRHR 156 Query: 534 RVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQELTADIISH 713 R++ PAF D +K K A + A + + ++ + + +T D + Sbjct: 157 RLLTPAFHFDILKPYMKIFNQSADIMHAKWRHLAEGSA---VSLDMFEHISLMTLDSLQK 213 Query: 714 TAFG--SSYKLGMEAFY-AQKELQAIAISSLLNVQ-IPGFSYLPTKRNRRKWMLEKKLRS 881 F S+ + M + A EL A+++ + F Y + RR + Sbjct: 214 CVFSYNSNCQEKMSDYISAIIELSALSVRRQYRLHHYLDFIYYRSADGRRFRQACDMVHH 273 Query: 882 TLMRIINSR---LASQGS--------GYGNDLLGLMLEGCTETEQGGKQEQLSLSMEEIL 1028 +I R L QG+ G D + ++L ++ GK+ LS E+I Sbjct: 274 FTTEVIQERRRALRQQGAEAWLKAKQGKTLDFIDVLL---LARDEDGKE----LSDEDIR 326 Query: 1029 HECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGKG----DPSGDNLGKL 1196 E TF F G++TTS ++W +F L+ YPE+QE+ R E+ +EV KG + D+L +L Sbjct: 327 AEADTFMFEGHDTTSSGISWMLFNLAKYPEYQEKCREEI-QEVMKGRELEELEWDDLTQL 385 Query: 1197 KEMTMVLHETLRLYGPALFMQRKTTTDMVV--GAITIPKEHAIVIGAPFMHRDKKVWGED 1370 TM + E+LR Y P + R+ T D+ + G I IPK ++ H + VW D Sbjct: 386 PFTTMCIKESLRQYPPVTLVSRQCTEDIKLPDGRI-IPKGIICLVSIYGTHHNPTVW-PD 443 Query: 1371 ADQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSP 1550 + +NP RF + + P A + FS GPR CIGQ+FAM E + V+A L +F ++ Sbjct: 444 SKVYNPYRFDPDNPQ-QRSPLAYVPFSAGPRNCIGQSFAMAELRVVVALTLLRFRLSVDR 502 Query: 1551 SYVHAPADFLTLRPKFGL 1604 + L LR + GL Sbjct: 503 TRKVRRKPELILRTENGL 520
>P78329:CP4F2_HUMAN Cytochrome P450 4F2 - Homo sapiens (Human)| Length = 520 Score = 120 bits (300), Expect = 3e-26 Identities = 113/420 (26%), Positives = 186/420 (44%), Gaps = 22/420 (5%) Frame = +3 Query: 339 AQYGEPFLFWFGA-KPRICVFDYELVRQILSSKSGHFPKNDAHPNXXXXXXXXXXXXXXX 515 A Y + F W G P + + +++R ++++ + PK+ + Sbjct: 82 ATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAG 141 Query: 516 D-WVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQEL 692 D W RHRR++ PAF + +K K ++ AS+ + ++ + + + Sbjct: 142 DKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGS---ACLDMFEHISLM 198 Query: 693 TADIISHTAFG-SSYKLGMEAFYAQKELQAIAISS------LLNVQIPGFSYLPTKRNRR 851 T D + F S+ + Y L+ A+ S LL++ + +R RR Sbjct: 199 TLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRR 258 Query: 852 KWMLEKKLRSTLMRIINSRLASQGSGYGNDLLGLMLEGCT---------ETEQGGKQEQL 1004 L +++ L SQG +D L + T ++ GK+ Sbjct: 259 ACRLVHDFTDAVIQERRRTLPSQGV---DDFLQAKAKSKTLDFIDVLLLSKDEDGKK--- 312 Query: 1005 SLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGKGDP---S 1175 LS E+I E TF F G++TT+ L+W ++ L+ +PE+QER R EV + +P Sbjct: 313 -LSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIE 371 Query: 1176 GDNLGKLKEMTMVLHETLRLYGPALFMQRKTTTDMVV-GAITIPKEHAIVIGAPFMHRDK 1352 D+L L +TM + E+LRL+ P + R T D+V+ IPK +I H + Sbjct: 372 WDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNP 431 Query: 1353 KVWGEDADQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKF 1532 VW D + ++P RF + + P A + FS GPR CIGQ FAM E K V+A L +F Sbjct: 432 AVW-PDPEVYDPFRFDPENIK-ERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRF 489
>Q3MID2:CP4F3_RAT Cytochrome P450 4F3 - Rattus norvegicus (Rat)| Length = 524 Score = 119 bits (299), Expect = 3e-26 Identities = 117/414 (28%), Positives = 182/414 (43%), Gaps = 24/414 (5%) Frame = +3 Query: 363 FWFGA-KPRICVFDYELVRQILSSKSGHFPKNDAHPNXXXXXXXXXXXXXXXD-WVRHRR 536 +W G P I +F ++ ++ + + PK+ D W RHRR Sbjct: 90 WWVGPWHPVIRIFHPAFIKPVILAPASVAPKDRVFYRFLRPWLGDGLLLSTGDKWSRHRR 149 Query: 537 VIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQELTADIISHT 716 ++ PAF + +K K ++ AS+ + + ++ + + +T D + Sbjct: 150 MLTPAFHFNILKPYVKIFNDSTNIMHAKWQRLASQGSAR---LDMFEHISLMTLDSLQKC 206 Query: 717 AFG---SSYKLGMEAFYAQKELQAIAI----SSLLNVQIPGFSYLPTKRNRRKWMLEKKL 875 F + + E A EL A+ S LL+V + R R+ L Sbjct: 207 VFSFDSNCQEKPSEYITAILELSALVARRHQSLLLHVDLFYHLTRDGMRFRKACRLVHDF 266 Query: 876 RSTLMRIINSRLASQGSGYGNDLLGLMLEGCT---------ETEQGGKQEQLSLSMEEIL 1028 ++R L QG G+D L + T ++ G+ +LS E+I Sbjct: 267 TDAVIRERRCTLPDQG---GDDALKAKAKAKTLDFIDVLLLSKDEHGE----ALSDEDIR 319 Query: 1029 HECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEV---LREVGKGDPSGDNLGKLK 1199 E TF F G++TT+ L+W ++ L+ +PE+QER R EV LR+ + D+L +L Sbjct: 320 AEADTFMFGGHDTTASGLSWILYNLAKHPEYQERCRQEVRELLRDREPEEIEWDDLAQLP 379 Query: 1200 EMTMVLHETLRLYGPALFMQRKTTTD-MVVGAITIPKEHAIVIGAPFMHRDKKVWGEDAD 1376 +TM + E+LRL+ PA + R T D M+ IPK I H + VW D + Sbjct: 380 FLTMCIKESLRLHPPATAISRCCTQDIMLPDGRVIPKGVICRISIFGTHHNPAVW-PDPE 438 Query: 1377 QFNPMRF--ANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKF 1532 +NP RF NG R+ P A + FS GPR CIGQ FAM E K +A L +F Sbjct: 439 VYNPFRFDADNGKGRS---PLAFIPFSAGPRNCIGQTFAMSEMKVALALTLLRF 489
>P98187:CP4F8_HUMAN Cytochrome P450 4F8 - Homo sapiens (Human)| Length = 520 Score = 119 bits (298), Expect = 4e-26 Identities = 111/420 (26%), Positives = 188/420 (44%), Gaps = 22/420 (5%) Frame = +3 Query: 339 AQYGEPFLFWFGA-KPRICVFDYELVRQILSSKSGHFPKNDAHPNXXXXXXXXXXXXXXX 515 A Y + F+ W G P I + ++VR ++++ K+ Sbjct: 82 ATYPQGFVRWLGPITPIINLCHPDIVRSVINTSDAITDKDIVFYKTLKPWLGDGLLLSVG 141 Query: 516 D-WVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQEL 692 D W HRR++ PAF + +K K A ++ A + + ++ + + + Sbjct: 142 DKWRHHRRLLTPAFHFNILKPYIKIFSKSANIMHAKWQRLAMEGSTC---LDVFEHISLM 198 Query: 693 TADIISHTAFG---SSYKLGMEAFYAQKELQAIAISSLLNV-QIPGFSYLPTKRNRR--- 851 T D + F + + E A EL A+ + + F Y T RR Sbjct: 199 TLDSLQKCIFSFDSNCQEKPSEYITAIMELSALVVKRNNQFFRYKDFLYFLTPCGRRFHR 258 Query: 852 ---------KWMLEKKLRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGGKQEQL 1004 +++++ R+ + ++ L ++ D + ++L ++ GK+ Sbjct: 259 ACRLVHDFTDAVIQERRRTLTSQGVDDFLQAKAKSKTLDFIDVLL---LSEDKNGKE--- 312 Query: 1005 SLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGKGDP---S 1175 LS E+I E TF F G++TT+ L+W ++ L+ +PE+QER R EV + +P Sbjct: 313 -LSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDREPKEIE 371 Query: 1176 GDNLGKLKEMTMVLHETLRLYGPALFMQRKTTTDMVV-GAITIPKEHAIVIGAPFMHRDK 1352 D+L +L +TM L E+LRL+ P R T D+V+ + IPK + I +H + Sbjct: 372 WDDLAQLPFLTMCLKESLRLHPPIPTFARGCTQDVVLPDSRVIPKGNVCNINIFAIHHNP 431 Query: 1353 KVWGEDADQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKF 1532 VW D + ++P RF A+ + P A + FS GPR CIGQ FAM E K V+A L +F Sbjct: 432 SVW-PDPEVYDPFRFDPENAQ-KRSPMAFIPFSAGPRNCIGQKFAMAEMKVVLALTLLRF 489
>Q02928:CP4AB_HUMAN Cytochrome P450 4A11 precursor - Homo sapiens (Human)| Length = 519 Score = 118 bits (296), Expect = 7e-26 Identities = 115/452 (25%), Positives = 207/452 (45%), Gaps = 20/452 (4%) Frame = +3 Query: 330 KWRAQYGEPFLFW-FGAKPRICVFDYELVRQILSSKSGHFPKND-AHPNXXXXXXXXXXX 503 KW + W +G K R+ ++D + ++ IL PK+ ++ Sbjct: 77 KWVETFPSACPHWLWGGKVRVQLYDPDYMKVILGRSD---PKSHGSYRFLAPWIGYGLLL 133 Query: 504 XXXXDWVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSV 683 W +HRR++ PAF D +K M + +EE +++ E+ + V Sbjct: 134 LNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVF----QHV 189 Query: 684 QELTADIISHTAFGSSYKLGMEAFYAQKELQAIA-ISSLLNVQIPGFS------YLPTKR 842 +T D I AF + ++ +Q +QAI+ +++L+ ++ Y T Sbjct: 190 SLMTLDTIMKCAFSHQGSIQVDR-NSQSYIQAISDLNNLVFSRVRNAFHQNDTIYSLTSA 248 Query: 843 NR---RKWMLEKKLRSTLMRIINSRLASQGS------GYGNDLLGLMLEGCTETEQGGKQ 995 R R L + ++++ ++L +G D L ++L + E G Sbjct: 249 GRWTHRACQLAHQHTDQVIQLRKAQLQKEGELEKIKRKRHLDFLDILL--LAKMENGS-- 304 Query: 996 EQLSLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGKGDP- 1172 LS +++ E TF F G++TT+ ++W ++ L+ +P+ QER R E+ +G G Sbjct: 305 ---ILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHSLLGDGASI 361 Query: 1173 SGDNLGKLKEMTMVLHETLRLYGPALFMQRKTTTDMVV-GAITIPKEHAIVIGAPFMHRD 1349 + ++L ++ TM + E LRLY P + R+ +T + ++PK +++ +H + Sbjct: 362 TWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHN 421 Query: 1350 KKVWGEDADQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQK 1529 KVW + + F+P RFA G A+ + HA L FS G R CIG+ FAM E K A L + Sbjct: 422 PKVW-PNPEVFDPFRFAPGSAQHS---HAFLPFSGGSRNCIGKQFAMNELKVATALTLLR 477 Query: 1530 FSFALSPSYVHAPADFLTLRPKFGLPVVMKLL 1625 F P+ + P L L+ K G+ + ++ L Sbjct: 478 FELLPDPTRIPIPIARLVLKSKNGIHLRLRRL 509
>P33268:CP3A8_MACFA Cytochrome P450 3A8 - Macaca fascicularis (Crab eating macaque)| (Cynomolgus monkey) Length = 503 Score = 118 bits (296), Expect = 7e-26 Identities = 103/413 (24%), Positives = 191/413 (46%), Gaps = 14/413 (3%) Frame = +3 Query: 342 QYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHFPKNDAHPNXXXXXXXXXXXXXXXDW 521 +YG+ + F+ G +P + + D +++ +L + N +W Sbjct: 67 KYGKVWGFYDGRQPVLAITDPNMIKTVLVKECYSVFTNRRPFGPVGFMKNAISIAEDEEW 126 Query: 522 VRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQEL--- 692 R R ++ P F K+K M + + + +N +E + +++++ Sbjct: 127 KRIRSLLSPTFTSGKLKEMVPIIAK--------YGDVLVRNLRREAETGKPVTLKDVFGA 178 Query: 693 -TADIISHTAFG---SSYKLGMEAFYAQ-KELQAIAISSLLNVQIPGFSYL-PTKRNRRK 854 + D+I+ T+FG S + F K+L + I F ++ P Sbjct: 179 YSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITIFPFIIPILEVLNI 238 Query: 855 WMLEKK----LRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGGKQEQLSLSMEE 1022 + ++ LR ++ RI SRL + D L LM++ E + +LS E Sbjct: 239 SIFPREVTSFLRKSVKRIKESRLKDTQK-HRVDFLQLMIDSQNSKET---ESHKALSDLE 294 Query: 1023 ILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREV-GKGDPSGDNLGKLK 1199 ++ + F FAGYETTS +L++ ++ L+ +P+ Q++L+ E+ + K P+ D + +++ Sbjct: 295 LVAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKLQEEIDTVLPNKAPPTYDTVLQME 354 Query: 1200 EMTMVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDADQ 1379 + MV++ETLR++ A+ ++R D+ + I IPK ++I + +H D K W E ++ Sbjct: 355 YLDMVVNETLRIFPIAMRLERVCKKDVEINGIFIPKGVVVMIPSYALHHDPKYWPE-PEK 413 Query: 1380 FNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSF 1538 F P RF+ P+ F GPR CIG FA++ K + VLQ FSF Sbjct: 414 FLPERFSKKNNDNID-PYIYTPFGSGPRNCIGMRFALMNMKLAIIRVLQNFSF 465
>O42563:CP3AR_ONCMY Cytochrome P450 3A27 - Oncorhynchus mykiss (Rainbow trout) (Salmo| gairdneri) Length = 518 Score = 118 bits (295), Expect = 1e-25 Identities = 96/412 (23%), Positives = 188/412 (45%), Gaps = 11/412 (2%) Frame = +3 Query: 342 QYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHFPKNDAHPNXXXXXXXXXXXXXXXDW 521 +YG + + G +P +C+ D +++ +L + + N + + W Sbjct: 68 KYGRIWGIYDGRQPVLCIMDKSMIKTVLIKECYNIFTNRRNFHLNGELFDALSVAEDDTW 127 Query: 522 VRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQELTAD 701 R R V+ P+F ++K M M + + ++QA K+ E++ F + D Sbjct: 128 RRIRSVLSPSFTSGRLKEMFGIMKQHSSTLLSGMKKQADKDQTIEVKEFFGP----YSMD 183 Query: 702 IISHTAFG---SSYKLGMEAFYAQ-KELQAIAISSLLNVQIPGFSYLPTKRNRRKWMLEK 869 +++ TAF S + F + K++ + + L + + F + + K+ Sbjct: 184 VVTSTAFSVDIDSLNNPSDPFVSNVKKMLKFDLFNPLFLLVALFPFTGPILEKMKFSFFP 243 Query: 870 KLRSTLMRIINSRLASQGSGYGN-----DLLGLMLEGCTETE-QGGKQEQLSLSMEEILH 1031 + +++ S G GN D L LM++ ++ + G+++ L+ EIL Sbjct: 244 TAVTDFFYASLAKIKS-GRDTGNSTNRVDFLQLMIDSQKGSDTKTGEEQTKGLTDHEILS 302 Query: 1032 ECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGKGDP-SGDNLGKLKEMT 1208 + F FAGYET+S +++ + L+ +L+ E+ P + L ++ + Sbjct: 303 QAMIFIFAGYETSSSTMSFLAYNLATNHHVMTKLQEEIDTVFPNKAPIQYEALMQMDYLD 362 Query: 1209 MVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDADQFNP 1388 VL+E+LRLY A ++R + + I IPK+ +++ +HRD ++W D ++F P Sbjct: 363 CVLNESLRLYPIAPRLERVAKKTVEINGIVIPKDCIVLVPTWTLHRDPEIWS-DPEEFKP 421 Query: 1389 MRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFAL 1544 RF+ + P+ + F GPR CIG FA++ K M +LQ F+F++ Sbjct: 422 ERFSKENKESID-PYTYMPFGAGPRNCIGMRFALIMIKLAMVEILQSFTFSV 472
>Q9V7G5:C4AA1_DROME Probable cytochrome P450 4aa1 - Drosophila melanogaster (Fruit fly)| Length = 514 Score = 118 bits (295), Expect = 1e-25 Identities = 119/458 (25%), Positives = 198/458 (43%), Gaps = 10/458 (2%) Frame = +3 Query: 285 VRDHDYLHRVAPHFLKWRAQYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHFPKNDAH 464 V D D + R A K YG W P V + E ++ ILSSK H K + Sbjct: 67 VTDKDLMRRCAG---KAFDLYGSLVRIWVLLFPFFAVLEPEDLQVILSSKK-HTNKVFFY 122 Query: 465 PNXXXXXXXXXXXXXXXDWVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKN 644 W HRR+I PAF + ++ T V +QS ++E ++ Sbjct: 123 RLMHNFLGDGLITSSGSKWSNHRRLIQPAFHHNLLEKFIDTFVDASQS---LYENLDAEA 179 Query: 645 TNKEIQVEFDKSVQELTADIISHTAFGSSYK-------LGMEAFYAQKELQAIAISSLLN 803 EI + K V DI++ G K + ++ + Q ++ A + Sbjct: 180 VGTEINIA--KYVNNCVLDILNEAVLGVPIKKRGQDVAMMEDSPFRQGKIMMPARFTQPW 237 Query: 804 VQIPGFSYLPTKRNRRKWMLEKKLRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQ 983 + + G Y TK + +K+L ++I R Q + GN +L+ E + Sbjct: 238 LLLDGI-YHWTKMANDELNQKKRLNDFTRKMIQRRRQIQNNNNGNSERKCLLDHMIEISE 296 Query: 984 GGKQEQLSLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQER--LRAEVLREV 1157 + + E+I++E TF AG ++ + +T+FLL+ PE Q+R L + E Sbjct: 297 SNRD----FTEEDIVNEACTFMLAGQDSVGAAVAFTLFLLTQNPECQDRCVLELATIFED 352 Query: 1158 GKGDPSGDNLGKLKEMTMVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPF 1337 P+ +L +++ M M + E LRLY + RK ++ + T+P + I Sbjct: 353 SNRAPTMTDLHEMRYMEMCIKEALRLYPSVPLIARKLGEEVRLAKHTLPAGSNVFICPYA 412 Query: 1338 MHRDKKVWGEDADQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMAT 1517 HR ++ D ++F P RF+ + + P+A L FS GPR CIG FA++E K++++ Sbjct: 413 THRLAHIY-PDPEKFQPERFSPENSEN-RHPYAFLPFSAGPRYCIGNRFAIMEIKTIVSR 470 Query: 1518 VLQKFSFALSPSYVHAPADF-LTLRPKFGLPVVMKLLD 1628 +L+ + A F +TLR GL V +K D Sbjct: 471 LLRSYQLLPVTGKTTIAATFRITLRASGGLWVRLKERD 508
>Q98T91:C340_ORYLA Cytochrome P450 3A40 - Oryzias latipes (Medaka fish) (Japanese| ricefish) Length = 502 Score = 118 bits (295), Expect = 1e-25 Identities = 101/415 (24%), Positives = 187/415 (45%), Gaps = 12/415 (2%) Frame = +3 Query: 336 RAQYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHFPKNDAHPNXXXXXXXXXXXXXXX 515 R +YG+ + + G +P +C+ D ++ +L + N + Sbjct: 65 RKKYGKTWGIYDGRQPVLCITDPATIKAVLVKECYSLFTNRRNFRLNGPLYDAVSIAEDD 124 Query: 516 DWVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQELT 695 W R R V+ P+F ++K M M + + + K +K+ +E + + Sbjct: 125 QWKRIRSVLSPSFTSGRLKEMFDIMKHHSANLI----QSMKKKVDKDEPLEMKEYFGPYS 180 Query: 696 ADIISHTAFG---SSYKLGMEAFYAQ-KELQAIAISSLLNVQIPGFSYLPTKRNRRKWML 863 D+++ TAF S + F K++ + L + + F +L + ++ L Sbjct: 181 MDVVTSTAFSVDIDSLNNPSDPFVTNIKKMLKFDFLNPLFLAVAFFPFLGPILEKFEFSL 240 Query: 864 EKKLRSTLMRIINSRLASQGSGYGN-------DLLGLMLEGCTETEQGGKQEQLSLSMEE 1022 S++M + L + + N D L LM++ + Q G Q++ LS E Sbjct: 241 ---FPSSVMDFFFAALRKIKANHENNKQKSRIDFLQLMIDS-QKNNQNGLQDK-GLSDHE 295 Query: 1023 ILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEV-LREVGKGDPSGDNLGKLK 1199 IL + F FAGYETTS LT+ + L+ PE ++L+ E+ K L +++ Sbjct: 296 ILSQAMIFIFAGYETTSSSLTFLAYNLATNPEVMKKLQKEIDATFPNKAPVQYVPLMEME 355 Query: 1200 EMTMVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDADQ 1379 + V++E+LRLY A ++R + V + IPK+ +++ +HRD ++W E ++ Sbjct: 356 YLDCVVNESLRLYPIAARLERVAKATVEVNGLVIPKDMVVMVPTWPLHRDPELWPE-PEK 414 Query: 1380 FNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFAL 1544 F P RF+ + P+ + F GPR CIG FA++ K + +LQ + F++ Sbjct: 415 FKPERFSK-ENKDTFDPYTYMPFGAGPRNCIGMRFALVMMKLAVVEILQTYDFSV 468
>P33270:CP6A2_DROME Cytochrome P450 6a2 - Drosophila melanogaster (Fruit fly)| Length = 506 Score = 117 bits (294), Expect = 1e-25 Identities = 108/431 (25%), Positives = 198/431 (45%), Gaps = 18/431 (4%) Frame = +3 Query: 294 HDYLHRVAPHFLKWRAQYGEPFL-FWFGAKPRICVFDYELVRQILSSKSGHFP-KNDAHP 467 HD+ + ++ K+R G PF+ F+F KP + D +L + IL +F + H Sbjct: 53 HDFFY---DYYNKYRKS-GFPFVGFYFLHKPAAFIVDTQLAKNILIKDFSNFADRGQFHN 108 Query: 468 NXXXXXXXXXXXXXXXDWVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNT 647 W R+ + P F K+K M T++ ++ V EQ Sbjct: 109 GRDDPLTQHLFNLDGKKWKDMRQRLTPTFTSGKMKFMFPTVIKVSEEFVKVITEQVPAAQ 168 Query: 648 NKEIQVEFDKSVQELTADIISHTAFG---SSYKLGMEAF--YAQKELQAIAISSLLNVQI 812 N + +E + + T D+I AFG ++ + + F QK + LL + + Sbjct: 169 NGAV-LEIKELMARFTTDVIGTCAFGIECNTLRTPVSDFRTMGQKVFTDMRHGKLLTMFV 227 Query: 813 PGFSYLPTKRNRRKWMLEKKLRSTLMRIINSRLA--SQGSGYGNDLLGLMLE----GCTE 974 F L ++ R M+ + + MR++N +A + + ND + L++E G Sbjct: 228 FSFPKLASRLRMR--MMPEDVHQFFMRLVNDTIALRERENFKRNDFMNLLIELKQKGRVT 285 Query: 975 TEQGGKQEQLSLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEV--L 1148 + G E + + E+ + F+ AG+ET+S +++ ++ L+ + Q+RLR E+ + Sbjct: 286 LDNGEVIEGMDIG--ELAAQVFVFYVAGFETSSSTMSYCLYELAQNQDIQDRLRNEIQTV 343 Query: 1149 REVGKGDPSGDNLGKLKEMTMVLHETLRLYGPALFMQRKTTTDMVVGA---ITIPKEHAI 1319 E +G + +++ + + V+ ETLRLY ++RK D VV + I K + Sbjct: 344 LEEQEGQLTYESIKAMTYLNQVISETLRLYTLVPHLERKALNDYVVPGHEKLVIEKGTQV 403 Query: 1320 VIGAPFMHRDKKVWGEDADQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEA 1499 +I A HRD+ ++ + + F+P RF+ AA+ L F GPR CIG F ++A Sbjct: 404 IIPACAYHRDEDLY-PNPETFDPERFSPEKV-AARESVEWLPFGDGPRNCIGMRFGQMQA 461 Query: 1500 KSVMATVLQKF 1532 + +A ++ +F Sbjct: 462 RIGLAQIISRF 472
>Q8N118:CP4X1_HUMAN Cytochrome P450 4X1 - Homo sapiens (Human)| Length = 509 Score = 117 bits (294), Expect = 1e-25 Identities = 114/449 (25%), Positives = 191/449 (42%), Gaps = 21/449 (4%) Frame = +3 Query: 342 QYGEPFLFWFGA-KPRICVFDYELVRQILSSKSGHFPKND-AHPNXXXXXXXXXXXXXXX 515 +Y F FW G + C++D + + +LS PK+ Sbjct: 75 KYPRAFPFWIGPFQAFFCIYDPDYAKTLLSRTD---PKSQYLQKFSPPLLGKGLAALDGP 131 Query: 516 DWVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQELT 695 W +HRR++ P F + +KA + M + +E+ S ++ VE + + ++ Sbjct: 132 KWFQHRRLLTPGFHFNILKAYIEVMAHSVKMMLDKWEKICS---TQDTSVEVYEHINSMS 188 Query: 696 ADIISHTAFG--------SSYKLGMEAFYAQKELQAIAISSLLNVQIPGFSYLPTKRNRR 851 DII AF S++ +A + ++ + SLL F P + Sbjct: 189 LDIIMKCAFSKETNCQTNSTHDPYAKAIFELSKIIFHRLYSLLYHSDIIFKLSPQGYRFQ 248 Query: 852 KWMLEKKLRSTLMRIINSRLASQGSGYGND---------LLGLMLEGCTETEQGGKQEQL 1004 K L + L II R S +G D L ++L E+ Sbjct: 249 K--LSRVLNQYTDTIIQERKKSLQAGVKQDNTPKRKYQDFLDIVLSAKDESGS------- 299 Query: 1005 SLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGKGDP-SGD 1181 S S ++ E TF AG++T + ++W ++ L++ PE QER R EV +G G + D Sbjct: 300 SFSDIDVHSEVSTFLLAGHDTLAASISWILYCLALNPEHQERCREEVRGILGDGSSITWD 359 Query: 1182 NLGKLKEMTMVLHETLRLYGPALFMQRKTTTDMVV-GAITIPKEHAIVIGAPFMHRDKKV 1358 LG++ TM + ET RL + R + + T+P +V+ +H + V Sbjct: 360 QLGEMSYTTMCIKETCRLIPAVPSISRDLSKPLTFPDGCTLPAGITVVLSIWGLHHNPAV 419 Query: 1359 WGEDADQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSF 1538 W ++ F+P+RF+ + + P+A L FS G R CIGQ FAM+E K +A +L F Sbjct: 420 W-KNPKVFDPLRFSQENSDQ-RHPYAYLPFSAGSRNCIGQEFAMIELKVTIALILLHFRV 477 Query: 1539 ALSPSYVHAPADFLTLRPKFGLPVVMKLL 1625 P+ + L+PK G+ + +K L Sbjct: 478 TPDPTRPLTFPNHFILKPKNGMYLHLKKL 506
>Q9HBI6:CP4FB_HUMAN Cytochrome P450 4F11 - Homo sapiens (Human)| Length = 524 Score = 117 bits (294), Expect = 1e-25 Identities = 112/423 (26%), Positives = 188/423 (44%), Gaps = 27/423 (6%) Frame = +3 Query: 345 YGEPFLFWFGAK-PRICVFDYELVRQILSSKSGHFPKNDAHPNXXXXXXXXXXXXXXXD- 518 Y + F W G P + + +++R I S+ + PK+ D Sbjct: 84 YPQGFKLWLGPTFPLLILCHPDIIRPITSASAAVAPKDMIFYGFLKPWLGDGLLLSGGDK 143 Query: 519 WVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQELTA 698 W RHRR++ PAF + +K K ++ AS+ + + ++ + + +T Sbjct: 144 WSRHRRMLTPAFHFNILKPYMKIFNKSVNIMHDKWQRLASEGSAR---LDMFEHISLMTL 200 Query: 699 DIISHTAFG---------SSYK---LGMEAFYAQKELQAIAISSLLNVQIPGFSYLPTKR 842 D + F S Y L + AF ++ Q + + L P +R Sbjct: 201 DSLQKCVFSFESNCQEKPSEYIAAILELSAFVEKRNQQILLHTDFLYYLTPD-----GQR 255 Query: 843 NRRKW---------MLEKKLRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGGKQ 995 RR +++++ R+ + I+ L ++ D + ++L ++ GK+ Sbjct: 256 FRRACHLVHDFTDAVIQERRRTLPTQGIDDFLKNKAKSKTLDFIDVLL---LSKDEDGKE 312 Query: 996 EQLSLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGKGDP- 1172 LS E+I E TF F G++TT+ L+W ++ L+ +PE+QE+ R EV + +P Sbjct: 313 ----LSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQEQCRQEVQELLKDREPI 368 Query: 1173 --SGDNLGKLKEMTMVLHETLRLYGPALFMQRKTTTDMVV-GAITIPKEHAIVIGAPFMH 1343 D+L +L +TM + E+LRL+ P + R T D V+ IPK +I +H Sbjct: 369 EIEWDDLAQLPFLTMCIKESLRLHPPVPVISRCCTQDFVLPDGRVIPKGIVCLINIIGIH 428 Query: 1344 RDKKVWGEDADQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVL 1523 + VW D + ++P RF N + P A + FS GPR CIGQ FAM E K V+A L Sbjct: 429 YNPTVW-PDPEVYDPFRF-NQENIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALTL 486 Query: 1524 QKF 1532 F Sbjct: 487 LHF 489
>P51871:CP4F6_RAT Cytochrome P450 4F6 - Rattus norvegicus (Rat)| Length = 537 Score = 117 bits (294), Expect = 1e-25 Identities = 102/360 (28%), Positives = 167/360 (46%), Gaps = 22/360 (6%) Frame = +3 Query: 519 WVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQELTA 698 W HRR++ PAF D +K+ K + ++ +K + + ++ + + +T Sbjct: 144 WNHHRRLLTPAFHFDILKSYVKIFNKSVNTMHAKWQRLTAKGSAR---LDMFEHISLMTL 200 Query: 699 DIISHTAFGSSYKLGMEAFYAQKELQAIAISSLL-NVQIPGFSYLPT--------KRNRR 851 D + F S+ + ++ + +SSL+ Q F YL +R R+ Sbjct: 201 DSLQKCIF--SFDSNCQESNSEYIAAILELSSLIVKRQRQPFLYLDFLYYLTADGRRFRK 258 Query: 852 KWMLEKKLRSTLMRIINSRLASQG---------SGYGNDLLGLMLEGCTETEQGGKQEQL 1004 + ++R S L +QG D + ++L E +G Sbjct: 259 ACDVVHNFTDAVIRERRSTLNTQGVDEFLKARAKTKTLDFIDVLLLAKDEHGKG------ 312 Query: 1005 SLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEV---LREVGKGDPS 1175 LS +I E TF F G++TT+ L+W ++ L+ +PE+QER R EV LR+ + Sbjct: 313 -LSDVDIRAEADTFMFGGHDTTASALSWILYNLARHPEYQERCRQEVRELLRDREPEEIE 371 Query: 1176 GDNLGKLKEMTMVLHETLRLYGPALFMQRKTTTDMVV-GAITIPKEHAIVIGAPFMHRDK 1352 D+L +L +TM + E+LRL+ P L + R + D+V+ IPK + VI +H + Sbjct: 372 WDDLAQLPFLTMCIKESLRLHPPVLLISRCCSQDIVLPDGRVIPKGNICVISIFGVHHNP 431 Query: 1353 KVWGEDADQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKF 1532 VW D + +NP RF + + P A + FS GPR CIGQ FAM E K +A L +F Sbjct: 432 SVW-PDPEVYNPFRF-DPENPQKRSPLAFIPFSAGPRNCIGQTFAMSEIKVALALTLLRF 489
>P79102:CP3AS_BOVIN Cytochrome P450 3A28 - Bos taurus (Bovine)| Length = 507 Score = 117 bits (294), Expect = 1e-25 Identities = 103/413 (24%), Positives = 187/413 (45%), Gaps = 14/413 (3%) Frame = +3 Query: 342 QYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHFPKNDAHPNXXXXXXXXXXXXXXXDW 521 +YG+ + F+ G +P + + D ++++ +L + N W Sbjct: 67 KYGKMWGFYEGRQPMLAITDPDIIKTVLVKECYSVFTNRRIFGPMGIMKYAISLAWDEQW 126 Query: 522 VRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQEL--- 692 R R ++ PAF K+K M + G + + +N KE + +++++ Sbjct: 127 KRIRTLLSPAFTSGKLKEMFPII--------GQYGDMLVRNLRKEAEKGNPVNMKDMFGA 178 Query: 693 -TADIISHTAFG---SSYKLGMEAFYAQ-KELQAIAISSLLNVQIPGFSYL-PTKRNRRK 854 + D+I+ TAFG S + F K L + I F +L P Sbjct: 179 YSMDVITGTAFGVNIDSLNNPHDPFVEHSKNLLRFRPFDPFILSIILFPFLNPVFEILNI 238 Query: 855 WMLEKK----LRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGGKQEQLSLSMEE 1022 + K ++ +I SRL + DLL LM+ E + +LS E Sbjct: 239 TLFPKSTVDFFTKSVKKIKESRLTDKQMNRV-DLLQLMINSQNSKEIDNHK---ALSDIE 294 Query: 1023 ILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREV-GKGDPSGDNLGKLK 1199 ++ + F F GYETTS L++ ++ L+ +P Q++L+ E+ K P+ D L +++ Sbjct: 295 LVAQSTIFIFGGYETTSSTLSFIIYELTTHPHVQQKLQEEIDATFPNKAPPTYDALVQME 354 Query: 1200 EMTMVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDADQ 1379 + MV++ETLR++ A ++R D+ + +TIPK +++ +H + ++W E ++ Sbjct: 355 YLDMVVNETLRMFPIAGRLERVCKKDVEIHGVTIPKGTTVLVPLFVLHNNPELWPE-PEE 413 Query: 1380 FNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSF 1538 F P RF+ + P+ L F GPR C+G FA++ K + +LQ FSF Sbjct: 414 FRPERFSKNNKDSIN-PYVYLPFGTGPRNCLGMRFAIMNIKLALVRILQNFSF 465
>P51538:CP3A9_RAT Cytochrome P450 3A9 - Rattus norvegicus (Rat)| Length = 503 Score = 117 bits (294), Expect = 1e-25 Identities = 104/413 (25%), Positives = 192/413 (46%), Gaps = 14/413 (3%) Frame = +3 Query: 342 QYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHFPKNDAHPNXXXXXXXXXXXXXXXDW 521 +YG+ + + G +P + + D ++++ +L + N + +W Sbjct: 67 KYGKLWGLYDGRQPVLAITDPDIIKTVLVKECYSTFTNRRNFGPVGILKKAISISEDEEW 126 Query: 522 VRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQEL--- 692 R R ++ P F K+K M + + + +N + + S++++ Sbjct: 127 KRIRALLSPTFTSGKLKEMFPII--------NQYTDMLVRNMRQGSEEGKPTSMKDIFGA 178 Query: 693 -TADIISHTAFG---SSYKLGMEAFYAQ-KELQAIAISSLLNVQIPGFSYL-PTKRNRRK 854 + D+I+ T+FG S + F + K+L I L + + F +L P Sbjct: 179 YSMDVITATSFGVNVDSLNNPQDPFVEKVKKLLKFDIFDPLFLSVTLFPFLTPLFEALNV 238 Query: 855 WMLEKKL----RSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGGKQEQLSLSMEE 1022 M + + ++++ R+ +R+ + D L LM+ K +LS E Sbjct: 239 SMFPRDVIDFFKTSVERMKENRMKEKEK-QRMDFLQLMINSQNSKV---KDSHKALSDVE 294 Query: 1023 ILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREV-GKGDPSGDNLGKLK 1199 I+ + F FAGYETTS L++ ++LL+++P+ Q++L+ E+ + K + D L +++ Sbjct: 295 IVAQSVIFIFAGYETTSSALSFVLYLLAIHPDIQKKLQDEIDAALPNKAHATYDTLLQME 354 Query: 1200 EMTMVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDADQ 1379 + MV++ETLRLY A ++R TD+ + + IPK ++I +H+D W E ++ Sbjct: 355 YLDMVVNETLRLYPIAGRLERVCKTDVEINGVFIPKGTVVMIPTFALHKDPHYWPE-PEE 413 Query: 1380 FNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSF 1538 F P RF+ P+ L F GPR CIG FA++ K + VLQ FSF Sbjct: 414 FRPERFSKKNQDNIN-PYMYLPFGNGPRNCIGMRFALMNMKVALFRVLQNFSF 465
>O35728:CP4AE_MOUSE Cytochrome P450 4A14 precursor - Mus musculus (Mouse)| Length = 507 Score = 117 bits (293), Expect = 2e-25 Identities = 104/393 (26%), Positives = 176/393 (44%), Gaps = 24/393 (6%) Frame = +3 Query: 519 WVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQELTA 698 W +HRR++ PAF D +K K M + + ++ K ++ +E V +T Sbjct: 136 WFQHRRMLTPAFHYDILKPYVKIMAD----SVNIMLDKWEKLDGQDHPLEIFHCVSLMTL 191 Query: 699 DIISHTAFGSSYKLGMEAFYAQKELQAIAISSLLNVQIPGFSYLPTKRNRRKWMLEKKLR 878 D + AF SY+ G +L A+ L N+ ++ + K+ + + Sbjct: 192 DTVMKCAF--SYQ-GSVQLDENSKLYTKAVEDLNNL-----TFFRLRNAFYKYNIIYNMS 243 Query: 879 STLMRIINSRLASQGSGYGND-------LLGLMLEGCTETEQGGKQEQL----------- 1004 S + RL+ ++ + L+ E ++ K+ L Sbjct: 244 S------DGRLSHHACQIAHEHTDGVIKMRKSQLQNEEELQKARKKRHLDFLDILLFARM 297 Query: 1005 ----SLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGKG-D 1169 SLS E++ E TF F G++TT+ ++W + L+ +PE Q+R R EV +G G Sbjct: 298 EDRNSLSDEDLRAEVDTFMFEGHDTTASGISWIFYALATHPEHQQRCREEVQSILGDGTS 357 Query: 1170 PSGDNLGKLKEMTMVLHETLRLYGPALFMQRKTTTDMVV-GAITIPKEHAIVIGAPFMHR 1346 + D+LG++ TM + E LRLY P + + R+ ++ + +IPK I +H Sbjct: 358 VTWDHLGQMPYTTMCIKEALRLYPPVISVSRELSSPVTFPDGRSIPKGITATISIYGLHH 417 Query: 1347 DKKVWGEDADQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQ 1526 + + W + F+P RFA + + HA L FS G R CIG+ FAM E K +A L Sbjct: 418 NPRFW-PNPKVFDPSRFAPDSSHHS---HAYLPFSGGSRNCIGKQFAMNELKVAVALTLL 473 Query: 1527 KFSFALSPSYVHAPADFLTLRPKFGLPVVMKLL 1625 +F P+ + P L L+ K G+ + +K L Sbjct: 474 RFELLPDPTRIPVPIARLVLKSKNGIHLCLKKL 506
>P24464:CP4AC_RAT Cytochrome P450 4A12 - Rattus norvegicus (Rat)| Length = 508 Score = 117 bits (293), Expect = 2e-25 Identities = 100/386 (25%), Positives = 174/386 (45%), Gaps = 17/386 (4%) Frame = +3 Query: 519 WVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQELTA 698 W +HRR++ PAF D +K M + +E+ +++ EI + + +T Sbjct: 137 WFQHRRMLTPAFHYDTLKPYVGIMADSVRIMLDKWEQIVGQDSTLEIF----QHITLMTL 192 Query: 699 DIISHTAFGSSYKLGMEAFY-----AQKELQAIAISSLLNVQIPGFSYLPTKRNRRK--- 854 D I AF + ++ Y A ++L ++ + N+ N RK Sbjct: 193 DTIMKCAFSQEGSVQLDRKYKSYIKAVEDLNNLSFFRIRNIFHQNDIIYSLSSNGRKARS 252 Query: 855 -WMLEKKLRSTLMRIINSRLASQGS------GYGNDLLGLMLEGCTETEQGGKQEQLSLS 1013 W L + +++ ++L + D L ++L E G SLS Sbjct: 253 AWQLAHEHTDQVIKSRKAQLQDEEELQKVKQKRRLDFLDILL--FARIENGS-----SLS 305 Query: 1014 MEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGKGDP-SGDNLG 1190 +++ E TF F G++TT+ ++W + L+ PE Q+ R E+ +G G + D+L Sbjct: 306 DKDLRAEVDTFMFEGHDTTASGISWIFYALATNPEHQQGCRKEIQSLLGDGASITWDDLD 365 Query: 1191 KLKEMTMVLHETLRLYGPALFMQRKTTTDMVV-GAITIPKEHAIVIGAPFMHRDKKVWGE 1367 K+ TM + E LR+Y P + R +T + ++PK +++ +H + VW Sbjct: 366 KMPYTTMCIKEALRIYPPVTAVSRMLSTPVTFPDGRSLPKGITVMLSFYGLHHNPTVW-P 424 Query: 1368 DADQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALS 1547 + + F+P RFA +R + H+ L FS G R CIG+ FAM E K +A L +F Sbjct: 425 NPEVFDPYRFAPESSRHS---HSFLPFSGGARNCIGKQFAMNELKVAVALTLLRFELLPD 481 Query: 1548 PSYVHAPADFLTLRPKFGLPVVMKLL 1625 P+ + P L L+ K G+ + +K L Sbjct: 482 PTRIPIPIPRLVLKSKNGIYLRLKKL 507
>P14580:CP4A6_RABIT Cytochrome P450 4A6 precursor - Oryctolagus cuniculus (Rabbit)| Length = 510 Score = 117 bits (293), Expect = 2e-25 Identities = 111/453 (24%), Positives = 202/453 (44%), Gaps = 20/453 (4%) Frame = +3 Query: 327 LKWRAQYGEPFLFW-FGAKPRICVFDYELVRQILSSKSGHFPK-NDAHPNXXXXXXXXXX 500 LKW ++ W +G++ + ++D + ++ IL PK ++ Sbjct: 76 LKWVEKFPSACPRWLWGSRAHLLIYDPDYMKVILGRSD---PKAQGSYRFLAPWIGYGLL 132 Query: 501 XXXXXDWVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKS 680 W +HRR++ PAF D +K M Q +E+ S++++ E+ + Sbjct: 133 LLNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVQIMLDKWEQLVSQDSSLEVF----QD 188 Query: 681 VQELTADIISHTAFGSSYKLGMEAFYAQKELQAIA---------ISSLLNVQIPGFSYLP 833 + +T D I AF + ++ +Q +QA+ + ++ + + P Sbjct: 189 ISLMTLDTIMKCAFSHQGSVQLDR-NSQSYIQAVGDLNNLFFSRVRNVFHQSDTIYRLSP 247 Query: 834 TKR-NRRKWMLEKKLRSTLMRIINSRLASQGS------GYGNDLLGLMLEGCTETEQGGK 992 R + R L + +++ ++L +G D L ++L + E G Sbjct: 248 EGRLSHRACQLAHEHTDRVIQQRKAQLQQEGELEKVRRKRRLDFLDVLL--FAKMENGS- 304 Query: 993 QEQLSLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGKGDP 1172 SLS +++ E TF F G++TT+ ++W + L+ +PE Q R R E+ +G G Sbjct: 305 ----SLSDQDLRAEVDTFMFEGHDTTASGISWIFYALATHPEHQHRCREEIQGLLGDGAS 360 Query: 1173 -SGDNLGKLKEMTMVLHETLRLYGPALFMQRKTTTDMVV-GAITIPKEHAIVIGAPFMHR 1346 + ++L ++ TM + E LRLY P + R+ ++ + ++PK + + +H Sbjct: 361 ITWEHLDQMPYTTMCIKEALRLYPPVPGVGRQLSSPVTFPDGRSLPKGVIVTLSIYALHH 420 Query: 1347 DKKVWGEDADQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQ 1526 + KVW + + F+P FA G AR + HA L FS GPR CIG+ FAM E K +A L Sbjct: 421 NPKVW-PNPEVFDPFPFAPGSARHS---HAFLPFSGGPRNCIGKQFAMNELKVAVALTLV 476 Query: 1527 KFSFALSPSYVHAPADFLTLRPKFGLPVVMKLL 1625 +F P V L L+ G+ + ++ L Sbjct: 477 RFELLPDPKRVPDQKPRLVLKSSNGIHLRLRKL 509
>P20816:CP4A2_RAT Cytochrome P450 4A2 precursor - Rattus norvegicus (Rat)| Length = 504 Score = 117 bits (293), Expect = 2e-25 Identities = 113/462 (24%), Positives = 200/462 (43%), Gaps = 18/462 (3%) Frame = +3 Query: 294 HDYLHRVAPHFLKWRAQYGEPFLFWF-GAKPRICVFDYELVRQILSSKSGHFPKNDAHPN 470 H+ R L W ++ L W G+ R+ ++D + V+ +L PK + + Sbjct: 62 HNLKDREFQQVLTWVEKFPGACLQWLSGSTARVLLYDPDYVKVVLGRSD---PK--PYQS 116 Query: 471 XXXXXXXXXXXXXXXDWVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTN 650 W +HRR++ PAF D +K K M + + ++ K + Sbjct: 117 LAPWIGYGLLLLNGKKWFQHRRMLTPAFHYDILKPYVKIMAD----SVSIMLDKWEKLDD 172 Query: 651 KEIQVEFDKSVQELTADIISHTAFGSSYKLGMEAFYAQKELQAIAISSLLNVQIPGFSYL 830 ++ +E V +T D + AF + ++ +++L+ ++ Y Sbjct: 173 QDHPLEIFHYVSLMTLDTVMKCAFSHQGSVQLDVNSRSYTKAVEDLNNLIFFRVRSAFYG 232 Query: 831 PT---------KRNRRKWMLEKKLRSTLMRIINSRLASQGSGYGN------DLLGLMLEG 965 + + +RR + + +++ ++L ++ D L ++L Sbjct: 233 NSIIYNMSSDGRLSRRACQIAHEHTDGVIKTRKAQLQNEEELQKARKKRHLDFLDILLFA 292 Query: 966 CTETEQGGKQEQLSLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEV 1145 E GK SLS E++ E TF F G++TT+ ++W + L+ +PE QER R EV Sbjct: 293 KMED---GK----SLSDEDLRAEVDTFMFEGHDTTASGISWVFYALATHPEHQERCREEV 345 Query: 1146 LREVGKG-DPSGDNLGKLKEMTMVLHETLRLYGPALFMQRKTTTDMVV-GAITIPKEHAI 1319 +G G + D+L ++ TM + E LRLY P + R+ ++ + +IPK + Sbjct: 346 QSILGDGTSVTWDHLDQMPYTTMCIKEALRLYSPVPSVSRELSSPVTFPDGRSIPKGIRV 405 Query: 1320 VIGAPFMHRDKKVWGEDADQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEA 1499 I +H + W + F+P RF+ R + HA L FS G R CIG+ FAM E Sbjct: 406 TILIYGLHHNPSYW-PNPKVFDPSRFSPDSPRHS---HAYLPFSGGARNCIGKQFAMNEL 461 Query: 1500 KSVMATVLQKFSFALSPSYVHAPADFLTLRPKFGLPVVMKLL 1625 K +A L +F P+ + P L L+ K G+ + +K L Sbjct: 462 KVAVALTLLRFELLPDPTRIPVPMPRLVLKSKNGIHLRLKKL 503
>Q64464:CP3AD_MOUSE Cytochrome P450 3A13 - Mus musculus (Mouse)| Length = 503 Score = 117 bits (292), Expect = 2e-25 Identities = 102/412 (24%), Positives = 191/412 (46%), Gaps = 14/412 (3%) Frame = +3 Query: 342 QYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHFPKNDAHPNXXXXXXXXXXXXXXXDW 521 +YG+ + + G +P + + D ++++ +L + N +W Sbjct: 67 KYGKMWGLYDGRQPVLAITDPDIIKTVLVKECYSTFTNRRRFGPVGILKKAISISENEEW 126 Query: 522 VRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQEL--- 692 R R ++ P F ++K M + F + +N + + S++++ Sbjct: 127 KRIRALLSPTFTSGRLKEMFPII--------NQFTDVLVRNMRQGLGEGKPTSMKDIFGA 178 Query: 693 -TADIISHTAFG---SSYKLGMEAFYAQ-KELQAIAISSLLNVQIPGFSYLPTKRNRRKW 857 + D+I+ T+FG S + F + K+L I L + + F +L + Sbjct: 179 YSMDVITATSFGVNIDSLNNPQDPFVEKIKKLLKFDIFDPLFLSVTLFPFLTPVFDALNV 238 Query: 858 MLEKK-----LRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGGKQEQLSLSMEE 1022 L + +++ R+ +R+ + D L LM+ K+ +LS E Sbjct: 239 SLFPRDVISFFTTSVERMKENRMKEKEK-QRVDFLQLMINS---QNYKTKESHKALSDVE 294 Query: 1023 ILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREV-GKGDPSGDNLGKLK 1199 I+ + F FAGYETTS L++ ++LL+++P+ Q++L+ E+ + K + D L +++ Sbjct: 295 IVAQSVIFIFAGYETTSSALSFALYLLAIHPDVQKKLQDEIDAALPNKAPATYDTLLQME 354 Query: 1200 EMTMVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDADQ 1379 + MV++ETLRLY A ++R TD+ + + IPK ++I +H+D K W E ++ Sbjct: 355 YLDMVVNETLRLYPIAGRLERVCKTDVEINGLFIPKGTVVMIPTFALHKDPKYWPE-PEE 413 Query: 1380 FNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFS 1535 F P RF+ + P+ L F GPR CIG FA++ K + VLQ F+ Sbjct: 414 FRPERFSKKNQDSIN-PYMYLPFGSGPRNCIGMRFALINMKVALVRVLQNFT 464
>Q99N16:CP4F3_MOUSE Cytochrome P450 4F3 - Mus musculus (Mouse)| Length = 524 Score = 116 bits (291), Expect = 3e-25 Identities = 107/359 (29%), Positives = 164/359 (45%), Gaps = 21/359 (5%) Frame = +3 Query: 519 WVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQELTA 698 W RHRR++ PAF + +K K ++ ASK + + + + +T Sbjct: 144 WSRHRRMLTPAFHFNILKPYVKVFNDSTNIMHAKWQRLASKGS---AYLNMFEHISLMTL 200 Query: 699 DIISHTAFG---SSYKLGMEAFYAQKELQAIAISS----LLNVQIPGFSYLPTKRNRRKW 857 D + F + + E A EL A+ LL+V + + R R+ Sbjct: 201 DSLQKCVFSFDSNCQEKPSEYITAILELSALVARRHQRLLLHVDLFYYLTHDGMRFRKAC 260 Query: 858 MLEKKLRSTLMRIINSRLASQGSGYGNDLLGLMLEGCT---------ETEQGGKQEQLSL 1010 L ++R L QG G+D+L + T ++ GK +L Sbjct: 261 RLVHDFTDAVIRERRRTLLDQG---GDDVLKAKAKAKTLDFIDVLLLSKDEHGK----AL 313 Query: 1011 SMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEV---LREVGKGDPSGD 1181 S E+I E TF F G++TT+ L+W ++ L+ +PE+QER R EV LR+ + D Sbjct: 314 SDEDIRAEADTFMFGGHDTTASGLSWILYNLARHPEYQERCRQEVRELLRDREPEEIEWD 373 Query: 1182 NLGKLKEMTMVLHETLRLYGPALFMQRKTTTDMVV-GAITIPKEHAIVIGAPFMHRDKKV 1358 +L +L +TM + E+LRL+ P + R T D+V+ IPK I H + V Sbjct: 374 DLAQLPFLTMCIKESLRLHPPVTAISRCCTQDIVLPDGRVIPKGVISRISIFGTHHNPAV 433 Query: 1359 WGEDADQFNPMRF-ANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKF 1532 W D + ++P RF A+ V + P A + FS GPR CIGQ FAM E K +A L +F Sbjct: 434 W-PDPEVYDPFRFDADNV--KGRSPLAFIPFSAGPRNCIGQTFAMSEMKVALALTLLRF 489
>Q8SPK0:CP4AP_PIG Cytochrome P450 4A25 - Sus scrofa (Pig)| Length = 504 Score = 116 bits (291), Expect = 3e-25 Identities = 105/386 (27%), Positives = 178/386 (46%), Gaps = 17/386 (4%) Frame = +3 Query: 519 WVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQELTA 698 W + RR++ PAF D +K M Q +E+ +++ EI V +T Sbjct: 133 WFQRRRMLTPAFHYDILKPYVGLMAKSVQVMLDKWEQLVAQDPRLEIV----GPVSLMTL 188 Query: 699 DIISHTAF---GSSYKLG-----MEAFYAQKELQAIAISSLLNVQIPGFSYLPT-KRNRR 851 D I AF GS+ G ++A + K L +I S + P ++N R Sbjct: 189 DTIMKCAFSHQGSAQTDGDSHSYIQAIWDLKNLFSIRTKSAFLQNDIIYRLSPEGRKNHR 248 Query: 852 KWMLEKKLRSTLMRIINSRLASQGSGYGN------DLLGLMLEGCTETEQGGKQEQLSLS 1013 + + ++++ ++L QG D L ++L E+G SLS Sbjct: 249 AARIAHQHTDRVIQLRKAQLQKQGEMENVRKKRHLDFLDILL--LARMEKGN-----SLS 301 Query: 1014 MEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGKGDP-SGDNLG 1190 ++ E TF F G++TT+ ++W ++ L+ +PE Q+R R E+ +G G + D+L Sbjct: 302 DTDLRAEVDTFMFEGHDTTASGISWILYALASHPEHQQRCREEIQGLLGDGTSITWDHLD 361 Query: 1191 KLKEMTMVLHETLRLYGPALFMQRKTTTDMVV-GAITIPKEHAIVIGAPFMHRDKKVWGE 1367 ++ TM + E LRLY P + R+ + + ++P + + +H + +VW Sbjct: 362 QMPYTTMCIKEALRLYPPVPGVSRELSKPITFPDGRSLPAGIILSLSVYSLHHNPQVW-P 420 Query: 1368 DADQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALS 1547 + ++F+P RFA G AR + HA + FS G R CIG+ FAM E K +A L +F A Sbjct: 421 NPEEFDPSRFAPGSARHS---HAFMPFSGGSRNCIGKQFAMNEMKVAVALTLLRFELAPD 477 Query: 1548 PSYVHAPADFLTLRPKFGLPVVMKLL 1625 PS + L K G+ + ++ L Sbjct: 478 PSRKPTVIPEVVLHSKNGIHLKLRKL 503
>O18993:CP3AL_CALJA Cytochrome P450 3A21 - Callithrix jacchus (Common marmoset)| Length = 503 Score = 116 bits (291), Expect = 3e-25 Identities = 104/409 (25%), Positives = 184/409 (44%), Gaps = 10/409 (2%) Frame = +3 Query: 342 QYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHFPKNDAHPNXXXXXXXXXXXXXXXDW 521 +YG+ + + G +P + + D +++ +L + N +W Sbjct: 67 KYGKMWGIYDGRQPVLAITDPNIIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAQDDEW 126 Query: 522 VRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQELTAD 701 R R ++ P F K+K M + + +A K ++ F + D Sbjct: 127 KRIRSLLSPTFTSGKLKEMVPIIAQYGEVLVRNLRREAEKGKPINMKDIFGA----YSMD 182 Query: 702 IISHTAFG---SSYKLGMEAFY-AQKELQAIAISSLLNVQIPGFSYL-PTKRNRRKWMLE 866 +I+ T+FG S + F + K+L + I F +L P M Sbjct: 183 VITGTSFGVNIDSLNNPQDPFVESTKKLLRFDFLDPFFLSITIFPFLTPILEALNISMFP 242 Query: 867 KK----LRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGGKQEQLSLSMEEILHE 1034 + LR ++ RI SRL + D L LM++ E + +LS E++ + Sbjct: 243 RDSTSFLRKSIKRIKESRLKDTHK-HRVDFLQLMIDSQNSKET---ESDKALSDLELVAQ 298 Query: 1035 CKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREV-GKGDPSGDNLGKLKEMTM 1211 F FAGYETTS L++ ++ L+ +P+ Q++L+ E+ + K + D + +++ + M Sbjct: 299 SIIFIFAGYETTSSTLSFIMYELATHPDVQQKLQEEIDAVLPNKAPATYDTVLQMEYLDM 358 Query: 1212 VLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDADQFNPM 1391 V++ETLRL+ A+ ++R D+ + + IPK ++I + +H D K W E ++F P Sbjct: 359 VVNETLRLFPLAMRLERVCKKDVEINGVFIPKGVVVMIPSYALHYDPKYWTE-PEKFLPE 417 Query: 1392 RFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSF 1538 RF+ + P+ F GPR CIG FA++ K + VLQ FSF Sbjct: 418 RFSKN-NKDNIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSF 465
>P47787:THAS_PIG Thromboxane-A synthase - Sus scrofa (Pig)| Length = 534 Score = 116 bits (290), Expect = 4e-25 Identities = 107/447 (23%), Positives = 184/447 (41%), Gaps = 39/447 (8%) Frame = +3 Query: 327 LKWRAQYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHFPKNDAHPNXXXXXXXXXXXX 506 ++ R QYG ++ G + + + D ++++Q+L+ K +F A Sbjct: 68 MELRKQYGPLSGYYLGRRMIVVISDPDMIKQVLAEKFSNFTNRMATGLESKPVADSILFL 127 Query: 507 XXXDWVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQ 686 W R V+ AF+ K+ +T + E A +IQ + Sbjct: 128 RDKRWEEVRSVLTSAFSPKKLNKLTPLISQACDLLLAHLERYAESGDAFDIQ----RCYC 183 Query: 687 ELTADIISHTAFGSSYKLGMEA------------FYAQKELQAIAISSLLNVQIPGFSYL 830 T D+++ AFG+ E ++ L + I S ++ +P L Sbjct: 184 CYTTDVVASVAFGTQVNSSEEPEHPFVKHCRRFFAFSVPRLILVLILSFPSIMVPLARIL 243 Query: 831 PTKRN-----------------RRKWMLEKKLRSTLMRIINSRLASQGSGYGN-DLLGLM 956 P K+ R + E++ + L +++ R ++ G N D++ Sbjct: 244 PNKKRDEVNGFFNKLIRNVIALRDQQAAEERRQDFLQMVLDLRHSAPSVGVENFDIVRQA 303 Query: 957 L---EGC-TETEQGGKQEQLS--LSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPE 1118 +GC + Q LS L+++E++ + F AGYE + L++ +LL+ P+ Sbjct: 304 FSSAKGCPADPSQPHLPRPLSKPLTVDEVVGQAFLFLIAGYEIITNTLSFVTYLLATNPD 363 Query: 1119 WQERLRAEVLREVGKGDPSGDNLGK---LKEMTMVLHETLRLYGPALFMQRKTTTDMVVG 1289 QE+L EV + K PS ++ L + MVL ETLR+Y PA R+ D V Sbjct: 364 CQEKLLREV-DDFSKKHPSPEHCSLQQGLPYLDMVLSETLRMYPPAFRFTREAARDCEVL 422 Query: 1290 AITIPKEHAIVIGAPFMHRDKKVWGEDADQFNPMRFANGVARAAKVPHALLAFSIGPRAC 1469 IP + + +H D K W + F+P RF A+ + P L F GPR+C Sbjct: 423 GQRIPAGTVLEVAVGALHHDPKHWPHP-ETFDPERFT-AEAQRLQQPFTYLPFGAGPRSC 480 Query: 1470 IGQNFAMLEAKSVMATVLQKFSFALSP 1550 +G +LE K + +L+KF F P Sbjct: 481 LGVQLGLLEIKLTLLHILRKFRFEACP 507
>Q9GJX5:CP4AL_PIG Cytochrome P450 4A21 - Sus scrofa (Pig)| Length = 504 Score = 116 bits (290), Expect = 4e-25 Identities = 107/379 (28%), Positives = 174/379 (45%), Gaps = 17/379 (4%) Frame = +3 Query: 519 WVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQELTA 698 W + RR++ PAF D +K M Q +E+ +++ EI V +T Sbjct: 133 WFQRRRMLTPAFHYDILKPYVGLMAKSVQVMLDKWEQLVAQDPRLEIV----GPVSLMTL 188 Query: 699 DIISHTAF---GSSYKLGMEAFYAQK--ELQAIAISSLLNVQIPG-FSYLPTKRNRRKWM 860 D I AF GS+ G Y Q +L+ + S L + + Y + R+ Sbjct: 189 DTIMKCAFSHQGSAQTDGDSQSYIQAIWDLKNLIFSRLRSAFLQNDIIYRLSPEGRQCQR 248 Query: 861 LEKKLRSTLMRIINSR---LASQGSGYGN------DLLGLMLEGCTETEQGGKQEQLSLS 1013 +K+ R+I R L +G D L ++L E G SLS Sbjct: 249 ACQKVHQHTDRVIQLRKTHLQKEGEMENVKKKRHLDFLDILL--FARMENGN-----SLS 301 Query: 1014 MEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGKGDP-SGDNLG 1190 ++ E TF AG+++T+ ++W ++ L+ PE Q+R R E+ +G G + D+L Sbjct: 302 DTDVRAEVDTFMAAGHDSTASGISWVLYALASNPEHQQRCREEIQGLLGDGTSITWDHLD 361 Query: 1191 KLKEMTMVLHETLRLYGPALFMQRKTTTDMVV-GAITIPKEHAIVIGAPFMHRDKKVWGE 1367 ++ TM + E LRLY P + R+ + + ++P + + +H + +VW Sbjct: 362 QMPYTTMCIKEALRLYPPVPSVGRELSKPITFPDGRSLPAGIILSLSIYGLHHNPQVW-P 420 Query: 1368 DADQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALS 1547 + ++F+P RFA G AR + HA + FS G R CIG+ FAM E K V+A L +F A Sbjct: 421 NPEEFDPSRFAPGSARHS---HAFMPFSGGSRNCIGKQFAMNEMKVVVALTLLRFELAPD 477 Query: 1548 PSYVHAPADFLTLRPKFGL 1604 PS + P + L+ K G+ Sbjct: 478 PSRIPVPIQGIVLKSKNGI 496
>P05184:CP3A3_HUMAN Cytochrome P450 3A3 - Homo sapiens (Human)| Length = 504 Score = 116 bits (290), Expect = 4e-25 Identities = 101/413 (24%), Positives = 194/413 (46%), Gaps = 14/413 (3%) Frame = +3 Query: 342 QYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHFPKNDAHPNXXXXXXXXXXXXXXXDW 521 +YG+ + F+ G +P + + D ++++ +L + N +W Sbjct: 67 KYGKVWGFYDGQQPVLAITDPDMIKLVLVKECYSVFTNREPFGPVGFMKSAISIAEDEEW 126 Query: 522 VRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQEL--- 692 R R ++ P F K+K M + + + +N +E + +++++ Sbjct: 127 KRLRSLLSPTFTSGKLKEMVPIIAQ--------YGDVLVRNLRRERETGKPVTLKDVFGA 178 Query: 693 -TADIISHTAFG---SSYKLGMEAFYAQ-KELQAIAISSLLNVQIPGFSYL-PTKRNRRK 854 + D+I+ ++FG S + K+L + I F +L P Sbjct: 179 YSMDVITSSSFGVNVDSLNNPQDPLVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNI 238 Query: 855 WMLEKK----LRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGGKQEQLSLSMEE 1022 + ++ LR + R+ SRL + D L LM++ +++ + +LS E Sbjct: 239 CVFPREVTNFLRKAVKRMKESRLEDTQK-HRVDFLQLMIDSHKNSKE--TESHKALSDLE 295 Query: 1023 ILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREV-GKGDPSGDNLGKLK 1199 ++ + F FAGYETTS +L++ ++ L+ +P+ Q++L+ E+ + K P+ D + +++ Sbjct: 296 LVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQME 355 Query: 1200 EMTMVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDADQ 1379 + MV++ETLRL+ A+ ++R D+ + + IPK ++I + +HRD K W E ++ Sbjct: 356 YLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGWVVMIPSYALHRDPKYWTE-PEK 414 Query: 1380 FNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSF 1538 F P RF+ + P+ F GPR CIG FA++ K + VLQ FSF Sbjct: 415 FLPERFSK-KNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSF 466
>P20817:CP4AE_RAT Cytochrome P450 4A14 precursor - Rattus norvegicus (Rat)| Length = 507 Score = 115 bits (289), Expect = 5e-25 Identities = 118/463 (25%), Positives = 203/463 (43%), Gaps = 19/463 (4%) Frame = +3 Query: 294 HDYLHRVAPHFLKWRAQYGEPFLFWF-GAKPRICVFDYELVRQILSSKSGHFPK-NDAHP 467 HD R L W ++ L W G+K R+ ++D + V+ +L PK + + Sbjct: 62 HDLKDREFQQVLTWVEKFPGACLQWLSGSKTRVLLYDPDYVKVVLGRSD---PKASGIYQ 118 Query: 468 NXXXXXXXXXXXXXXXDWVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNT 647 W +HRR++ PAF +K K M + + ++ K Sbjct: 119 FLAPWIGYGLLLLNGKKWFQHRRMLTPAFHYGILKPYVKIMAD----SVNIMLDKWEKLD 174 Query: 648 NKEIQVEFDKSVQELTADIISHTAFG--SSYKLGMEAFYAQKELQAIAISSLLNVQIP-- 815 +++ +E V +T D + AF S +L + + K ++ + + V+ Sbjct: 175 DQDHPLEIFHYVSLMTLDTVMKCAFSHQGSVQLDVNSRSYTKAVEDLNNLTFFRVRSAFY 234 Query: 816 GFSYLPT-----KRNRRKWMLEKKLRSTLMRIINSRLASQGSGYGN------DLLGLMLE 962 G S + + +RR + + ++++ ++L ++ D L ++L Sbjct: 235 GNSIIYNMSSDGRLSRRACQIAHEHTDGVIKMRKAQLQNEEELQKARKKRHLDFLDILLF 294 Query: 963 GCTETEQGGKQEQLSLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAE 1142 E GK SLS E++ E TF F G++TT+ ++W + L+ +PE QER R E Sbjct: 295 AKMED---GK----SLSDEDLRAEVDTFMFEGHDTTASGISWVFYALATHPEHQERCREE 347 Query: 1143 VLREVGKG-DPSGDNLGKLKEMTMVLHETLRLYGPALFMQRKTTTDMVV-GAITIPKEHA 1316 V +G G + D+L ++ TM + E LRLY P + R+ ++ + +IPK Sbjct: 348 VQSILGDGTSVTWDHLDQIPYTTMCIKEALRLYPPVPSVSRELSSPVTFPDGRSIPKGIT 407 Query: 1317 IVIGAPFMHRDKKVWGEDADQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLE 1496 I +H + W + F+P RF+ R + HA L FS G R CIG+ FAM E Sbjct: 408 TTILIYGLHHNPSYW-PNPKVFDPSRFSPDSPRHS---HAYLPFSGGARNCIGKQFAMNE 463 Query: 1497 AKSVMATVLQKFSFALSPSYVHAPADFLTLRPKFGLPVVMKLL 1625 K +A L +F P+ + P L L+ K G+ + +K L Sbjct: 464 LKVAVALTLLRFELLPDPTRIPVPMARLVLKSKNGIHLRLKKL 506
>P70085:CP17A_ORYLA Cytochrome P450 17A1 - Oryzias latipes (Medaka fish) (Japanese| ricefish) Length = 517 Score = 115 bits (289), Expect = 5e-25 Identities = 126/510 (24%), Positives = 208/510 (40%), Gaps = 22/510 (4%) Frame = +3 Query: 141 LVRLVWRPYAVARRHRAQGIHGPPYRFLRGSNEEVRRMKAETAHVVLHVRDHDYLHRVAP 320 L L+WR V R R Q PY + GS +R HV+ Sbjct: 17 LAALLWR---VRTRDRPQEAPSLPYLPVLGSLLSLR--SPHPPHVL-------------- 57 Query: 321 HFLKWRAQYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHF---PKNDAHPNXXXXXXX 491 F + + +YG+ + G+ I V + R++L + F P+ Sbjct: 58 -FKELQQKYGQTYSLKMGSHQVIIVNHHAHAREVLLKRGRTFAGRPRTVTTDVLTRDGKD 116 Query: 492 XXXXXXXXDWVRHRRVIDPAFAMDKIKAMTKTMVSC--AQSTFGVFEEQASKNTNKEIQV 665 W HR+++ A M + + + C AQS E A+ ++ Sbjct: 117 IAFGDYSATWRFHRKIVHGALCMFGEGSASLQRIICTEAQSLCSTLSEAAATGLALDLSP 176 Query: 666 EFDKSVQELTADIISHTAFGSSYKLGMEAF-----YAQKELQAIAISSLLNVQIPGFSYL 830 E ++V ++I F SSY G F Y+Q + +A SL+++ P Sbjct: 177 ELTRAV----TNVICSLCFNSSYSRGDPEFEAMLRYSQGIVDTVAKDSLVDI-FPWLQIF 231 Query: 831 PTKRNRRKWMLEKKLRSTLMRIINSRLASQGSGYGN----DLLGLMLEGCTETEQGG--- 989 P K R L K+ + +++ + S Y + DLL +L E Sbjct: 232 PNKDLR----LLKQCVAVRDQLLQKKFEEHKSDYSDHVQRDLLDALLRAKRSAENNNTAA 287 Query: 990 --KQEQLSLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVG- 1160 E + LS + +L F AG ETT+ +L W + L YPE Q++++ E+ R+VG Sbjct: 288 EFSAEAVGLSDDHLLMTVGDIFGAGVETTTTVLKWAITYLIHYPEVQKQIQEELDRKVGV 347 Query: 1161 KGDPSGDNLGKLKEMTMVLHETLRLYGPA-LFMQRKTTTDMVVGAITIPKEHAIVIGAPF 1337 P + G L + + E LR+ A L + +D +G T+ K +VI Sbjct: 348 DRPPQLSDRGSLPFLEATIREVLRIRPVAPLLIPHVALSDTSLGDFTVRKGTRVVINLWS 407 Query: 1338 MHRDKKVWGEDADQFNPMRFANGVARAAKVP-HALLAFSIGPRACIGQNFAMLEAKSVMA 1514 +H D+K W + D FNP RF + + +P + L F G R C+G+ A +E ++ Sbjct: 408 LHHDEKEW-TNPDLFNPGRFLSADGSSLTLPSSSYLPFGAGLRVCLGEALAKMELFLFLS 466 Query: 1515 TVLQKFSFALSPSYVHAPADFLTLRPKFGL 1604 +LQ+F+ ++ PS +L KFG+ Sbjct: 467 WILQRFTLSVPPS-----QSLPSLEGKFGV 491
>Q27593:CP6A8_DROME Cytochrome P450 6a8 - Drosophila melanogaster (Fruit fly)| Length = 506 Score = 114 bits (284), Expect = 2e-24 Identities = 119/470 (25%), Positives = 200/470 (42%), Gaps = 18/470 (3%) Frame = +3 Query: 186 RAQGIHGPPYRFLRGSNEEVRRMKAETAHVVLHVRDHDYLHRV-APHFLKWRAQYGEPFL 362 + +GI +RG+ EE+++ K +H + H+ K+R Sbjct: 30 KRRGIPFVAPHLIRGNMEELQKTKN--------------IHEIFQDHYNKFRESKAPFVG 75 Query: 363 FWFGAKPRICVFDYELVRQILSSKSGHFPKNDAHPNXXXXXXXXXXXXXXX-DWVRHRRV 539 F+F P V D EL +QIL +F N W R Sbjct: 76 FFFFQSPAAFVIDLELAKQILIKDFSNFSNKGIFYNEKDDPISAHLFNLDGAQWRLLRNK 135 Query: 540 IDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQELTADIISHTA 719 + F K+K M T+VS A V E+ KN+ EI+ V T D+I A Sbjct: 136 LSSTFTSGKMKLMYPTVVSVANEFMTVMHEKVPKNSVLEIR----DLVARFTVDVIGTCA 191 Query: 720 FGSSYKLGMEA-----FYAQKELQAIAISSLLNVQIPGFSYLPTKRNRRKWMLEKK--LR 878 FG + ++ ++ L +LLN GF K R+ M+ ++ Sbjct: 192 FGIQCNSLRDEKAEFLYFGKRSLVDKRHGTLLN----GFMRSYPKLARKLGMVRTAPHIQ 247 Query: 879 STLMRIINSRLASQGSGY--GNDLLGLMLEGCTETEQGGKQEQL--SLSMEEILHECKTF 1046 RI+ +A + + ND + +++E + E + + L+MEE+L + F Sbjct: 248 EFYSRIVTETVAVREKEHIKRNDFMDMLIELKNQKEMTLENGDVVRGLTMEEVLAQAFVF 307 Query: 1047 FFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGKGDP--SGDNLGKLKEMTMVLH 1220 F AG+ET+S + + ++ L+ P+ Q+++RAEV + + D + + LK + VL Sbjct: 308 FIAGFETSSSTMGFALYELAKNPDIQDKVRAEVEEVIEQHDQNFTYECTKDLKYLNQVLD 367 Query: 1221 ETLRLYGPALFMQRKTTTDMVVGA---ITIPKEHAIVIGAPFMHRDKKVWGEDADQFNPM 1391 ETLRLY + R VV I +++I + +H D ++ E +F P Sbjct: 368 ETLRLYTIVPNLDRMAAKRYVVPGHPNFVIEAGQSVIIPSSAIHHDPSIYPEPF-EFRPE 426 Query: 1392 RFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFA 1541 RF+ + A + A L F GPR CIG F ++A+ +A +++ F F+ Sbjct: 427 RFSPEES-AGRPSVAWLPFGDGPRNCIGLRFGQMQARIGLALLIRNFKFS 475
>Q9VXY0:CP4S3_DROME Probable cytochrome P450 4s3 - Drosophila melanogaster (Fruit fly)| Length = 495 Score = 113 bits (283), Expect = 2e-24 Identities = 119/454 (26%), Positives = 181/454 (39%), Gaps = 24/454 (5%) Frame = +3 Query: 336 RAQYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHFPKNDAHPNXXXXXXXXXXXXXXX 515 R ++G F WFG + D E ++Q+L + K+ + Sbjct: 60 REKHGPVFRIWFGKDLMVMFTDPEDIKQLLGNNQ-LLTKSRNYELLEPWLGKGLLTNGGE 118 Query: 516 DWVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQELT 695 W R R+++ P F + + M + + + N E + + Sbjct: 119 SWHRRRKLLTPGFHFRILSEFKEPM----EENCRILVRRLRTKANGE-SFDIYPYITLFA 173 Query: 696 ADIISHTAFG----------SSYKLGMEAFYAQKELQAIAISSLLNVQIPGFSYLPTKRN 845 D I TA G S Y +++ Q+ + LNV + TK Sbjct: 174 LDAICETAMGIKKHAQLQSDSEYVQAVQSICRVMHKQSFSFWQRLNV-----FFKHTKPG 228 Query: 846 RRKWMLEKKLRSTLMRIINSRL-------------ASQGS-GYGNDLLGLMLEGCTETEQ 983 + + K L R+I R A Q G L L + T+ E Sbjct: 229 KEREAALKVLHDETNRVIRLRREQLIQERNEWKPEAEQDDVGAKRRLAFLDMLLLTQMEG 288 Query: 984 GGKQEQLSLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGK 1163 G + LS +I E TF F G++TTS + + + LLS P+ Q+R E G+ Sbjct: 289 GAE-----LSDTDIREEVDTFMFEGHDTTSSAIAFALSLLSKNPDVQQRAFEEASELEGR 343 Query: 1164 GDPSGDNLGKLKEMTMVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMH 1343 S + + V+ ETLR+Y F RK D+ VG +T+PK +I +H Sbjct: 344 EKES------MPYLEAVIKETLRIYPSVPFFSRKVLEDLEVGKLTVPKGASISCLIYMLH 397 Query: 1344 RDKKVWGEDADQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVL 1523 RD K + D ++F+P RF V P A AFS GPR CIGQ FAMLE K+ +A +L Sbjct: 398 RDPKNF-PDPERFDPDRFL--VNEKQMHPFAFAAFSAGPRNCIGQKFAMLELKTSLAMLL 454 Query: 1524 QKFSFALSPSYVHAPADFLTLRPKFGLPVVMKLL 1625 + + F P H P L K G + +++L Sbjct: 455 RSYRFL--PDKDHQPKPLAELVTKSGNGIRLRIL 486
>P11707:CP3A6_RABIT Cytochrome P450 3A6 - Oryctolagus cuniculus (Rabbit)| Length = 501 Score = 113 bits (282), Expect = 3e-24 Identities = 104/416 (25%), Positives = 186/416 (44%), Gaps = 10/416 (2%) Frame = +3 Query: 327 LKWRAQYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHFPKNDAHPNXXXXXXXXXXXX 506 ++ R +YG+ + + G +P + + D ++++ +L + N Sbjct: 60 IECRKKYGKMWGLFDGRQPLMVITDPDMIKTVLVKECYSVFTNRRSFGPVGFMKKAVSIS 119 Query: 507 XXXDWVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQ 686 DW R R ++ P F K+K M + ++A K +++ F Sbjct: 120 EDEDWKRVRTLLSPTFTSGKLKEMLPIIAQYGDVLVKNLRQEAEKGKPVDLKEIFGA--- 176 Query: 687 ELTADIISHTAFG---SSYKLGMEAFYAQ-KELQAIAISSLLNVQIPGFSYL-PTKRNRR 851 + D+I+ T+FG S + + F + L + L + I F +L P Sbjct: 177 -YSMDVITGTSFGVNIDSLRNPQDPFVKNVRRLLKFSFFDPLLLSITLFPFLTPIFEALH 235 Query: 852 KWMLEKK----LRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGGKQEQLSLSME 1019 M K L++++ +I + RL + D L LM+ E + +L Sbjct: 236 ISMFPKDVMDFLKTSVEKIKDDRLKDKQKRRV-DFLQLMINSQNSKEIDSHK---ALDDI 291 Query: 1020 EILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREV-GKGDPSGDNLGKL 1196 E++ + FAGYETTS L++ + LL+ +P+ Q++L+ E+ + K + D L K+ Sbjct: 292 EVVAQSIIILFAGYETTSSTLSFIMHLLATHPDVQQKLQEEIDTLLPNKELATYDTLVKM 351 Query: 1197 KEMTMVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDAD 1376 + + MV++ETLRLY A ++R D+ + IPK +++ +HRD + W E D Sbjct: 352 EYLDMVVNETLRLYPIAGRLERVCKKDVDINGTFIPKGTIVMMPTYALHRDPQHWTE-PD 410 Query: 1377 QFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFAL 1544 +F P RF+ P+ F GPR C+G FA++ K + ++Q FSF L Sbjct: 411 EFRPERFSKKNKDNIN-PYIYHPFGAGPRNCLGMRFALMNIKLALVRLMQNFSFKL 465
>P63719:CP139_MYCTU Putative cytochrome P450 139 - Mycobacterium tuberculosis| Length = 430 Score = 113 bits (282), Expect = 3e-24 Identities = 100/373 (26%), Positives = 160/373 (42%), Gaps = 5/373 (1%) Frame = +3 Query: 516 DWVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQELT 695 D R R V+ P ++ TMVS + ++ +I E +V+ T Sbjct: 73 DHRRRRSVVAPGLRHHHVQRYVATMVSNIDTVIDGWQP----GQRLDIYQELRSAVRRST 128 Query: 696 ADIISHTAFGSSYKLGMEAFYAQKELQAIAISSLLNVQIPGFSYLPTKRNRRKWMLEKKL 875 A+ + FG +L + + + ++LQ + L + P L + N W Sbjct: 129 AESL----FGQ--RLAVHSDFLGEQLQPLLD---LTRRPPQVMRLQQRVNSPGWRRAMAA 179 Query: 876 RSTLMRIINSRLASQGSGYGND--LLGLMLEGCTETEQGGKQEQLSLSMEEILHECKTFF 1049 R + +I++++A + D +L ++ GC+E E +LS EI + Sbjct: 180 RKRIDDLIDAQIADARTAPRPDDHMLTTLISGCSE-------EGTTLSDNEIRDSIVSLI 232 Query: 1050 FAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGKGDPSGDNLGKLKEMTMVLHETL 1229 AGYETTS L W ++ L P E +EV R +G P+ D+L L + V+HETL Sbjct: 233 TAGYETTSGALAWAIYALLTVPGTWESAASEVARVLGGRVPAADDLSALTYLNGVVHETL 292 Query: 1230 RLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDADQFNPMRFANGV 1409 RLY P + R+ D+ I ++ A HR ++W E +F P+R+ Sbjct: 293 RLYSPGVISARRVLRDLWFDGHRIRAGRLLIFSAYVTHRLPEIWPEPT-EFRPLRWDPNA 351 Query: 1410 ARAAK-VPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSPSYVH--APADFL 1580 A K PH + FS G CIG A E ++A ++ + L H A+F Sbjct: 352 ADYRKPAPHEFIPFSGGLHRCIGAVMATTEMTVILARLVARAMLQLPAQRTHRIRAANFA 411 Query: 1581 TLRPKFGLPVVMK 1619 LRP GL V ++ Sbjct: 412 ALRPWPGLTVEIR 424
>P63720:CP139_MYCBO Putative cytochrome P450 139 - Mycobacterium bovis| Length = 430 Score = 113 bits (282), Expect = 3e-24 Identities = 100/373 (26%), Positives = 160/373 (42%), Gaps = 5/373 (1%) Frame = +3 Query: 516 DWVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQELT 695 D R R V+ P ++ TMVS + ++ +I E +V+ T Sbjct: 73 DHRRRRSVVAPGLRHHHVQRYVATMVSNIDTVIDGWQP----GQRLDIYQELRSAVRRST 128 Query: 696 ADIISHTAFGSSYKLGMEAFYAQKELQAIAISSLLNVQIPGFSYLPTKRNRRKWMLEKKL 875 A+ + FG +L + + + ++LQ + L + P L + N W Sbjct: 129 AESL----FGQ--RLAVHSDFLGEQLQPLLD---LTRRPPQVMRLQQRVNSPGWRRAMAA 179 Query: 876 RSTLMRIINSRLASQGSGYGND--LLGLMLEGCTETEQGGKQEQLSLSMEEILHECKTFF 1049 R + +I++++A + D +L ++ GC+E E +LS EI + Sbjct: 180 RKRIDDLIDAQIADARTAPRPDDHMLTTLISGCSE-------EGTTLSDNEIRDSIVSLI 232 Query: 1050 FAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGKGDPSGDNLGKLKEMTMVLHETL 1229 AGYETTS L W ++ L P E +EV R +G P+ D+L L + V+HETL Sbjct: 233 TAGYETTSGALAWAIYALLTVPGTWESAASEVARVLGGRVPAADDLSALTYLNGVVHETL 292 Query: 1230 RLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDADQFNPMRFANGV 1409 RLY P + R+ D+ I ++ A HR ++W E +F P+R+ Sbjct: 293 RLYSPGVISARRVLRDLWFDGHRIRAGRLLIFSAYVTHRLPEIWPEPT-EFRPLRWDPNA 351 Query: 1410 ARAAK-VPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSPSYVH--APADFL 1580 A K PH + FS G CIG A E ++A ++ + L H A+F Sbjct: 352 ADYRKPAPHEFIPFSGGLHRCIGAVMATTEMTVILARLVARAMLQLPAQRTHRIRAANFA 411 Query: 1581 TLRPKFGLPVVMK 1619 LRP GL V ++ Sbjct: 412 ALRPWPGLTVEIR 424
>P59954:CP132_MYCBO Putative cytochrome P450 132 - Mycobacterium bovis| Length = 461 Score = 113 bits (282), Expect = 3e-24 Identities = 96/382 (25%), Positives = 166/382 (43%), Gaps = 17/382 (4%) Frame = +3 Query: 519 WVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQELTA 698 W RHR ++ FA ++ + M+ A Q + +S+ E T Sbjct: 101 WARHRGALNSTFARRHLRGLVGLMIDPIADVTAALVPGA--------QFDMHQSMVETTL 152 Query: 699 DIISHTAFG--------SSYKLGMEAFYAQKELQAIAISSLLNVQI---------PGFSY 827 ++++ F S + L ++L+ + + L+ + G Sbjct: 153 RVVANALFSQDFGPLVQSMHDLATRGLRRAEKLERLGLWGLMPRTVYDTLIWCIYSGVHL 212 Query: 828 LPTKRNRRKWMLEKKLRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGGKQEQLS 1007 P R ++ L L + +I+ RLA + DLL ++L GG + Sbjct: 213 PPPLREMQEITLT--LDRAINSVIDRRLAEPTNSA--DLLNVLLSA-----DGGIWPR-- 261 Query: 1008 LSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGKGDPSGDNL 1187 + + E TF AG+ETT+ ++W +L+++ P+ ++ + E+ +G P+ D+L Sbjct: 262 ---QRVRDEALTFMLAGHETTANAMSWFWYLMALNPQARDHMLTELDDVLGMRRPTADDL 318 Query: 1188 GKLKEMTMVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGE 1367 GKL T L E+ R + + R+ D ++ I + +VI +H D + W Sbjct: 319 GKLAWTTACLQESQRYFSSVWIIAREAVDDDIIDGHRIRRGTTVVIPIHHIHHDPR-WWP 377 Query: 1368 DADQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALS 1547 D D+F+P RF + A L F G R CIGQ+FA++E + A + Q F+F L+ Sbjct: 378 DPDRFDPGRFLRCPTDRPRC--AYLPFGGGRRICIGQSFALMEMVLMAAIMSQHFTFDLA 435 Query: 1548 PSYVHAPADFLTLRPKFGLPVV 1613 P Y LTLRPK G+ V+ Sbjct: 436 PGYHVELEATLTLRPKHGVHVI 457
>O08394:CYPD_BACSU Probable bifunctional P-450:NADPH-P450 reductase 1 [Includes:| Cytochrome P450 102 - Bacillus subtilis Length = 1061 Score = 112 bits (280), Expect = 5e-24 Identities = 105/375 (28%), Positives = 170/375 (45%), Gaps = 16/375 (4%) Frame = +3 Query: 516 DWVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQELT 695 +W + ++ P F+ +K + MV A + ++ A N N+ + V D + LT Sbjct: 97 NWRKAHNILMPTFSQRAMKDYHEKMVDIAVQ---LIQKWARLNPNEAVDVPGDMT--RLT 151 Query: 696 ADIIS----HTAFGSSYKLGMEAFY---------AQKELQAIAISSLLNVQIPGFSYLPT 836 D I + F S Y+ F A ++Q + + L V Sbjct: 152 LDTIGLCGFNYRFNSYYRETPHPFINSMVRALDEAMHQMQRLDVQDKLMV---------- 201 Query: 837 KRNRRKWMLEKKLRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGGKQEQLSLSM 1016 R +R++ + + +L+ I + + G DLL ML + E G K L Sbjct: 202 -RTKRQFRYDIQTMFSLVDSIIAERRANGDQDEKDLLARMLN-VEDPETGEK-----LDD 254 Query: 1017 EEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGKGDPSGDNLGKL 1196 E I + TF AG+ETTS LL++ + L +P+ ++ EV R + P+ + +L Sbjct: 255 ENIRFQIITFLIAGHETTSGLLSFATYFLLKHPDKLKKAYEEVDRVLTDAAPTYKQVLEL 314 Query: 1197 KEMTMVLHETLRLY--GPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGED 1370 + M+L+E+LRL+ PA + K T ++ G I I + P +HRD+ WG+D Sbjct: 315 TYIRMILNESLRLWPTAPAFSLYPKEDT-VIGGKFPITTNDRISVLIPQLHRDRDAWGKD 373 Query: 1371 ADQFNPMRFANGVARAAKVP-HALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALS 1547 A++F P RF + +VP HA F G RACIG FA+ EA V+ +L+ F+ Sbjct: 374 AEEFRPERFEH----QDQVPHHAYKPFGNGQRACIGMQFALHEATLVLGMILKYFTLIDH 429 Query: 1548 PSYVHAPADFLTLRP 1592 +Y LTL+P Sbjct: 430 ENYELDIKQTLTLKP 444
>Q27606:CP4E2_DROME Cytochrome P450 4e2 - Drosophila melanogaster (Fruit fly)| Length = 526 Score = 112 bits (280), Expect = 5e-24 Identities = 110/430 (25%), Positives = 183/430 (42%), Gaps = 30/430 (6%) Frame = +3 Query: 333 WRAQYGEP-FLFWFGAKPRICVFDYELVRQILSSKSGHFPKNDAHPNXXXXXXXXXXXXX 509 W QYG+ F+FW G + V + + ILSS++ K+D + Sbjct: 62 WWHQYGKDNFVFWIGTYSNVLVTSSKYLEFILSSQT-LITKSDIYQLTHPWLGLGLLTST 120 Query: 510 XXDWVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQ--------- 662 W +HR++I PAF + ++ F E ++N+ K I+ Sbjct: 121 GSKWHKHRKMITPAFHFNILQD---------------FHEVMNENSTKFIKHLKTVAAGD 165 Query: 663 --VEFDKSVQELTADIISHTAFGSSYKLGMEAFYAQKELQAIAISSLLNVQIPGFSYLPT 836 +F + LT D+I TA G S ME + +QA N+ + F P Sbjct: 166 NIFDFQEQAHYLTLDVICDTAMGVSIN-AMEN-RSSSIVQAFK-DMCYNINMRAFH--PL 220 Query: 837 KRNRRKWMLE----------KKLRSTLMRIINSRLASQGSGY----GNDLLGLMLEGCTE 974 KRN + L K L+ II R+ + SG D + Sbjct: 221 KRNELLYRLAPDYPAYSRTLKTLQDFTNEIIAKRIEAHKSGAVSTNAGDEFTRKKMAFLD 280 Query: 975 TEQGGKQEQLSLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLRE 1154 T + L+ +E+ E TF F G++TT+ +++ V+LLS + + Q +L E Sbjct: 281 TLLSSTIDGRPLNSKELYEEVSTFMFEGHDTTTSGVSFAVYLLSRHQDEQRKLFKEQREV 340 Query: 1155 VGKGDPSGD----NLGKLKEMTMVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIV 1322 +G + D + ++K + + + E R+Y F+ R T D V+ +PK + Sbjct: 341 MGNSELGRDATFQEISQMKYLDLFIKEAQRVYPSVPFIGRFTEKDYVIDGDLVPKGTTLN 400 Query: 1323 IGAPFMHRDKKVWGEDADQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAK 1502 +G + ++KV+ +D +F P RF P + FS GPR CIGQ FA+LE K Sbjct: 401 LGLVMLGYNEKVF-KDPHKFRPERFE----LEKPGPFEYVPFSAGPRNCIGQKFALLEIK 455 Query: 1503 SVMATVLQKF 1532 +V++ +++ F Sbjct: 456 TVVSKIIRNF 465
>Q964T1:CP4CU_BLAGE Cytochrome P450 4c21 - Blattella germanica (German cockroach)| Length = 501 Score = 112 bits (280), Expect = 5e-24 Identities = 118/474 (24%), Positives = 197/474 (41%), Gaps = 37/474 (7%) Frame = +3 Query: 228 GSNEEVRRMKAE-----------TAHVVLHVRDHDYLHRVAPHFLKWRAQYGEPFLFW-F 371 G NEE +RM + TA +L+ R D + + K++ P + W F Sbjct: 22 GRNEERKRMLQKIPGAPSLPLIGTALPILYRRKEDRMTWIEEILEKYK-----PLILWYF 76 Query: 372 GAKPRICVFDYELVRQILSSKSGHFPKNDAHPNXXXXXXXXXXXXXXXDWVRHRRVIDPA 551 G +P + + EL+ +L + K + W +HR++I P Sbjct: 77 GNRPFVNISSPELIEVVLRNTQ-LIDKAFLYDLFHSWLGTGLLTSSGAKWHQHRKIITPT 135 Query: 552 FAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKS-------VQELTADIIS 710 F S + +F E+ S+ +++Q E + V DII Sbjct: 136 FHF-----------SILEGFITIFAEK-SEILVRKLQKEVGRGPFFIRQYVSNCALDIIC 183 Query: 711 HTAFGSSYKLGMEAFY----AQKELQAIAISSLLNVQI-PGFSYLPTKRNRRKWMLEKKL 875 TA G+S E F A ++ + + N + P F + T K L Sbjct: 184 ETAMGTSVNAQDEGFSEYVTAINKMTDVLSDRMANPLLYPEFIFKLTPYYWTHKKCLKVL 243 Query: 876 RSTLMRIINSRLASQG------SGYGNDLLGLMLEGCTETEQGGKQEQLSLSMEEILHEC 1037 + +II R + + D+ +T ++ L+ +IL E Sbjct: 244 NGFVNKIIQERKEERKKSKVTQTSEDADIGKKKRVPFLDTLLDASEDDNKLTDTDILEEV 303 Query: 1038 KTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGKGD---PSGDNLGKLKEMT 1208 TF F G++T S +TW +F L +PE QE EV +++ +G P+ +L + + Sbjct: 304 HTFMFEGHDTVSAAMTWLLFELGHHPEIQEEAYKEV-QDIFQGSDRVPTMADLNNMNYLE 362 Query: 1209 MVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGE----DAD 1376 V+ E+LRL+ ++ R+ D +G TIP I PF+HR+ +++ + D Sbjct: 363 RVIKESLRLHPSVIYFVREAHQDFELGGYTIPAGTNIDFSVPFIHRNPEIFPNPRCFNPD 422 Query: 1377 QFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSF 1538 F P R N + P+A + FS GPR CIGQ FA+LE K V++ +L+ + F Sbjct: 423 NFLPDRVVN------RHPYAYIPFSAGPRNCIGQRFALLEEKVVLSYLLRHYRF 470
>P77900:CP132_MYCTU Putative cytochrome P450 132 - Mycobacterium tuberculosis| Length = 461 Score = 112 bits (279), Expect = 7e-24 Identities = 96/382 (25%), Positives = 166/382 (43%), Gaps = 17/382 (4%) Frame = +3 Query: 519 WVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQELTA 698 W RHR ++ FA ++ + M+ A Q + +S+ E T Sbjct: 101 WARHRGALNSTFARRHLRGLVGLMIDPIADVTAARVPGA--------QFDMHQSMVETTL 152 Query: 699 DIISHTAFG--------SSYKLGMEAFYAQKELQAIAISSLLNVQI---------PGFSY 827 ++++ F S + L ++L+ + + L+ + G Sbjct: 153 RVVANALFSQDFGPLVQSMHDLATRGLRRAEKLERLGLWGLMPRTVYDTLIWCIYSGVHL 212 Query: 828 LPTKRNRRKWMLEKKLRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGGKQEQLS 1007 P R ++ L L + +I+ RLA + DLL ++L GG + Sbjct: 213 PPPLREMQEITLT--LDRAINSVIDRRLAEPTNSA--DLLNVLLSA-----DGGIWPR-- 261 Query: 1008 LSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGKGDPSGDNL 1187 + + E TF AG+ETT+ ++W +L+++ P+ ++ + E+ +G P+ D+L Sbjct: 262 ---QRVRDEALTFMLAGHETTANAMSWFWYLMALNPQARDHMLTELDDVLGMRRPTADDL 318 Query: 1188 GKLKEMTMVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGE 1367 GKL T L E+ R + + R+ D ++ I + +VI +H D + W Sbjct: 319 GKLAWTTACLQESQRYFSSVWIIAREAVDDDIIDGHRIRRGTTVVIPIHHIHHDPR-WWP 377 Query: 1368 DADQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALS 1547 D D+F+P RF + A L F G R CIGQ+FA++E + A + Q F+F L+ Sbjct: 378 DPDRFDPGRFLRCPTDRPRC--AYLPFGGGRRICIGQSFALMEMVLMAAIMSQHFTFDLA 435 Query: 1548 PSYVHAPADFLTLRPKFGLPVV 1613 P Y LTLRPK G+ V+ Sbjct: 436 PGYHVELEATLTLRPKHGVHVI 457
>Q08477:CP4F3_HUMAN Cytochrome P450 4F3 - Homo sapiens (Human)| Length = 520 Score = 111 bits (278), Expect = 9e-24 Identities = 104/358 (29%), Positives = 165/358 (46%), Gaps = 20/358 (5%) Frame = +3 Query: 519 WVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQELTA 698 W RHRR++ PAF + +K K ++ AS+ + + ++ + + +T Sbjct: 144 WSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSAR---LDMFEHISLMTL 200 Query: 699 DIISHTAFG-SSYKLGMEAFYAQKELQAIAISSLLNVQIP---GFSYLPT---KRNRRKW 857 D + F S+ + Y L+ A+ + + QI F Y T +R RR Sbjct: 201 DSLQKCVFSFDSHCQEKPSEYIAAILELSALVTKRHQQILLYIDFLYYLTPDGQRFRRAC 260 Query: 858 MLEKKLRSTLMRIINSRLASQGSGYGNDLLGLMLEGCT---------ETEQGGKQEQLSL 1010 L +++ L SQG +D L + T ++ GK+ L Sbjct: 261 RLVHDFTDAVIQERRRTLPSQGV---DDFLQAKAKSKTLDFIDVLLLSKDEDGKK----L 313 Query: 1011 SMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGKGDP---SGD 1181 S E+I E TF F G++TT+ L+W ++ L+ +PE+QER R EV + +P D Sbjct: 314 SDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWD 373 Query: 1182 NLGKLKEMTMVLHETLRLYGPALFMQRKTTTDMVV-GAITIPKEHAIVIGAPFMHRDKKV 1358 +L +L +TM + E+LRL+ P + R T D+V+ IPK +I H + V Sbjct: 374 DLAQLPFLTMCIKESLRLHPPVPAVSRCCTQDIVLPDGRVIPKGIICLISVFGTHHNPAV 433 Query: 1359 WGEDADQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKF 1532 W D + ++P RF + + P A + FS GPR CIGQ FAM E K V+ L +F Sbjct: 434 W-PDPEVYDPFRFDPKNIK-ERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLGLTLLRF 489
>Q9VL92:CP4E3_DROME Cytochrome P450 4e3 - Drosophila melanogaster (Fruit fly)| Length = 526 Score = 111 bits (278), Expect = 9e-24 Identities = 106/421 (25%), Positives = 178/421 (42%), Gaps = 18/421 (4%) Frame = +3 Query: 324 FLKWRAQYGEP-FLFWFGAKPRICVFDYELVRQILSSKSGHFPKNDAHPNXXXXXXXXXX 500 F W YG+ FLFW G I + + + + IL+S+ K+ + Sbjct: 59 FFDWWYDYGKDNFLFWIGYSSHIVMTNPKQLEYILNSQQ-LIQKSTIYDLLHPWLGHGLL 117 Query: 501 XXXXXDWVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKS 680 W +HR++I P+F + ++ + M F Q K + + ++F + Sbjct: 118 TSFGSKWHKHRKMITPSFHFNILQDFHEVM----NENSAKFMTQLKKASAGDTIIDFQEH 173 Query: 681 VQELTADIISHTAFGSSYKLGMEAFYAQKELQAIAISSLLNVQIPGFSYLPTKRNRRKWM 860 LT D+I TA G ME Q++ + + I ++ P KR+ R + Sbjct: 174 ANYLTLDVICDTAMGVPIN-AME----QRDSSIVQAFRDMCYNINMRAFHPFKRSNRVFS 228 Query: 861 LE----------KKLRSTLMRIINSRL-ASQGSGYGND---LLGLMLEGCTETEQGGKQE 998 L K L+ II R+ A Q G D L +T + Sbjct: 229 LTPEFSAYQKTLKTLQDFTYDIIEKRVYALQNGGSKEDHDPSLPRKKMAFLDTLLSSTID 288 Query: 999 QLSLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGKG---D 1169 L+ +EI E TF F G++TT+ ++++V+LLS +P+ Q +L E +G Sbjct: 289 GRPLTRQEIYEEVSTFMFEGHDTTTSGVSFSVYLLSRHPDVQRKLYREQCEVMGHDMNRS 348 Query: 1170 PSGDNLGKLKEMTMVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRD 1349 S + K+K + + + E R+Y F+ R D + +PK + + + + Sbjct: 349 VSFQEIAKMKYLDLFIKEAQRVYPSVPFIGRYCDKDYDINGSIVPKGTTLNLALILLGYN 408 Query: 1350 KKVWGEDADQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQK 1529 +++ +D F P RF P L FS GPR CIGQ FA+LE K+V++ V++ Sbjct: 409 DRIF-KDPHHFRPERFEE----EKPAPFEYLPFSAGPRNCIGQKFALLELKTVISKVVRS 463 Query: 1530 F 1532 F Sbjct: 464 F 464
>Q9VS79:CP4D8_DROME Cytochrome P450 4d8 - Drosophila melanogaster (Fruit fly)| Length = 463 Score = 111 bits (277), Expect = 1e-23 Identities = 114/431 (26%), Positives = 195/431 (45%), Gaps = 36/431 (8%) Frame = +3 Query: 348 GEPFLFWFGAKPRICVF--------DYELVRQILSSKSGHFPKNDAHPNXXXXXXXXXXX 503 G ++ FG R+ +F D EL Q+LSS+ H K+ + Sbjct: 16 GREYVLKFGHLQRVWIFNRLLIMSGDAELNEQLLSSQE-HLVKHPVYKVLGQWLGNGLLL 74 Query: 504 XXXXDWVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFD--K 677 W + R++I P F ++ + + ++A+ NT FD + Sbjct: 75 SDGKVWHQRRKIITPTFHFSILEQFVEVFDQQSNICVQRLAQKANGNT-------FDVYR 127 Query: 678 SVQELTADIISHTAFGSS-YKLGMEAF-YAQKELQAIAISS--LLNVQIPGFSYLPTKRN 845 S+ DII+ TA G+ Y E+ YA+ + A+ S ++V + Sbjct: 128 SICAAALDIIAETAMGTKIYAQANESTPYAEAVNECTALLSWRFMSVYLQVELLFTLTHP 187 Query: 846 RRKWMLEKKLRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGGKQEQLSL----- 1010 KW + +R+ M+ ++ + D +++ T E G + +++L Sbjct: 188 HLKWRQTQLIRT--MQEFTIKVIEKRRQALEDQQSKLMD--TADEDVGSKRRMALLDVLL 243 Query: 1011 ---------SMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVG- 1160 + +EI E TF F G++TT+ L++ + LS +PE Q ++ E+++ +G Sbjct: 244 MSTVDGRPLTNDEIREEVDTFMFEGHDTTTSALSFCLHELSRHPEVQAKMLEEIVQVLGT 303 Query: 1161 -KGDP-SGDNLGKLKEMTMVLHETLRLYGPALFMQRKTTTDM-----VVGAITIPKEHAI 1319 + P S +LG+LK M V+ E+LR+Y P + RK TD V G IP I Sbjct: 304 DRSRPVSIRDLGELKYMECVIKESLRMYPPVPIVGRKLQTDFKYTHSVHGDGVIPAGSEI 363 Query: 1320 VIGAPFMHRDKKVWGEDADQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEA 1499 +IG +HR + + + D+F P R NG +R A P ++ FS GPR CIGQ FA LE Sbjct: 364 IIGIFGVHRQPETF-PNPDEFIPERHENG-SRVA--PFKMIPFSAGPRNCIGQKFAQLEM 419 Query: 1500 KSVMATVLQKF 1532 K ++A +++++ Sbjct: 420 KMMLAKIVREY 430
>Q64581:CP3AI_RAT Cytochrome P450 3A18 - Rattus norvegicus (Rat)| Length = 497 Score = 111 bits (277), Expect = 1e-23 Identities = 108/415 (26%), Positives = 190/415 (45%), Gaps = 17/415 (4%) Frame = +3 Query: 342 QYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHFPKNDAHPNXXXXXXXXXXXXXXXDW 521 +YG+ + F+ G +P + + D E+++ +L + N +W Sbjct: 67 KYGKIWGFYEGPQPFLAIMDPEIIKMVLVKECYSVFTNRRCFGPMGFMKKAITMSEDEEW 126 Query: 522 VRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQELTAD 701 R R ++ P F K+K M M + + +K ++ F + D Sbjct: 127 KRLRTILSPTFTSGKLKEMFPLMRQYGDTLLKNLRREEAKGEPINMKDIFGA----YSMD 182 Query: 702 IISHTAFG---SSYKLGMEAFY--AQKELQ-AIAISSLLNV----------QIPGFSYLP 833 +I+ T+FG S + F A+K L+ I LL+V ++ FS P Sbjct: 183 VITGTSFGVNVDSLNNPQDPFVQKAKKILKFQIFDPFLLSVVLFPFLTPIYEMLNFSIFP 242 Query: 834 TKRNRRKWMLEKKLRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGGKQEQLSLS 1013 R+ KK T+ + +RL S D L LM+ T+ +G ++ Q +LS Sbjct: 243 ----RQSMNFFKKFVKTMKK---NRLDSNQKNRV-DFLQLMMN--TQNSKG-QESQKALS 291 Query: 1014 MEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREV-GKGDPSGDNLG 1190 E+ + F F GY+ TS +++ ++ L+ P Q++L+ E+ R + K + D L Sbjct: 292 DLEMAAQAIIFIFGGYDATSTSISFIMYELATRPNVQKKLQNEIDRALPNKAPVTYDALM 351 Query: 1191 KLKEMTMVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGED 1370 +++ + MV++E+LRLY A + R + D+ + + IPK + I +HR+ + W E Sbjct: 352 EMEYLDMVVNESLRLYPIATRLDRVSKKDVEINGVFIPKGTVVTIPIYPLHRNPEYWLE- 410 Query: 1371 ADQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFS 1535 ++FNP RF+ + + P+ L F GPR CIG FA++ K + VLQ F+ Sbjct: 411 PEEFNPERFSK-ENKGSIDPYVYLPFGNGPRNCIGMRFALISMKLAVIGVLQNFN 464
>Q64417:CP3AE_CAVPO Cytochrome P450 3A14 - Cavia porcellus (Guinea pig)| Length = 503 Score = 110 bits (276), Expect = 2e-23 Identities = 99/413 (23%), Positives = 179/413 (43%), Gaps = 9/413 (2%) Frame = +3 Query: 327 LKWRAQYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHFPKNDAHPNXXXXXXXXXXXX 506 ++ R +YG + + G +P + + + ++++ +L + N Sbjct: 62 IECRKKYGNMWGLYDGPQPVLAITEPDMIKAVLVKECYSVFTNRRSLVPVGFMKKAVSLS 121 Query: 507 XXXDWVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQ 686 +W R R + P F K+K M + ++A K +++ F Sbjct: 122 EDEEWKRIRTQLSPNFTSGKLKEMFPIIKQYGDVLVKNLRQEAEKGKPVQLKEIFGA--- 178 Query: 687 ELTADIISHTAFG---SSYKLGMEAFYAQ-KELQAIAISSLLNVQIPGFSYLPTKRNRRK 854 + DII TAFG S + F ++ ++L S + I F +L Sbjct: 179 -YSMDIIVATAFGVNVDSLNNPHDPFVSKARKLFRFDFLSPFLLSIVMFPFLTQLYEMLS 237 Query: 855 WML----EKKLRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGGKQEQLSLSMEE 1022 + K + ++ D L +ML + + +LS E Sbjct: 238 ISIFPRDSLKFFTKFVKKTKENHLESNKKQRVDFLQMMLNSQNFKDT---ESHKALSDVE 294 Query: 1023 ILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREV-GKGDPSGDNLGKLK 1199 IL + F FAGYETTS L++ ++ L+ +P+ Q++L+ E+ + + K P+ D + +++ Sbjct: 295 ILAQSIIFIFAGYETTSSTLSFIMYSLATHPDVQKKLQQEIDKTLPNKAFPTYDVMMEME 354 Query: 1200 EMTMVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDADQ 1379 + MV++ETLRLY ++R + D + ++ PK ++I + +HRD K W E D+ Sbjct: 355 YLDMVVNETLRLYPVTNRIERMSKKDFEINGMSFPKGTGVMIPSFALHRDSKYWPE-PDE 413 Query: 1380 FNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSF 1538 F P RF+ P+ + F GPR CIG A++ K + +LQ FSF Sbjct: 414 FRPERFSKKNKENID-PYIYMPFGNGPRNCIGMRMALMNLKLALIRLLQNFSF 465
>P24462:CP3A7_HUMAN Cytochrome P450 3A7 - Homo sapiens (Human)| Length = 503 Score = 110 bits (276), Expect = 2e-23 Identities = 93/350 (26%), Positives = 165/350 (47%), Gaps = 9/350 (2%) Frame = +3 Query: 516 DWVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQELT 695 +W R R ++ P F K+K M + +A T K + ++ + Sbjct: 125 EWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAE--TGKPVTLKHVFGAYSM- 181 Query: 696 ADIISHTAFG---SSYKLGMEAFYAQ-KELQAIAISSLLNVQIPGFSYL-PTKRNRRKWM 860 D+I+ T+FG S + F K+L + I F +L P + Sbjct: 182 -DVITSTSFGVSIDSLNNPQDPFVENTKKLLRFNPLDPFVLSIKVFPFLTPILEALNITV 240 Query: 861 LEKKLRSTL---MRIINSRLASQGSGYGNDLLGLMLEGCTETEQGGKQEQLSLSMEEILH 1031 +K+ S L ++ I + + D L LM++ + + +LS E++ Sbjct: 241 FPRKVISFLTKSVKQIKEGRLKETQKHRVDFLQLMIDSQNSKDS---ETHKALSDLELMA 297 Query: 1032 ECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREV-GKGDPSGDNLGKLKEMT 1208 + F FAGYETTS +L++ ++ L+ +P+ Q++++ E+ + K P+ D + +L+ + Sbjct: 298 QSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPTYDTVLQLEYLD 357 Query: 1209 MVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDADQFNP 1388 MV++ETLRL+ A+ ++R D+ + + IPK ++I + +H D K W E ++F P Sbjct: 358 MVVNETLRLFPVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWRE-PEKFLP 416 Query: 1389 MRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSF 1538 RF+ + P+ F GPR CIG FA++ K + VLQ FSF Sbjct: 417 ERFSK-KNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSF 465
>Q9VG40:CP134_DROME Probable cytochrome P450 313a4 - Drosophila melanogaster (Fruit fly)| Length = 478 Score = 110 bits (275), Expect = 2e-23 Identities = 100/411 (24%), Positives = 179/411 (43%), Gaps = 9/411 (2%) Frame = +3 Query: 342 QYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHFPKNDAHPNXXXXXXXXXXXXXXXDW 521 ++G W G P + V D ++V+ I +S K + W Sbjct: 63 KHGPTIFSWLGPIPFMIVSDPQVVQDIFTSPHC-VNKGIIYKAVDDGAGVGLFSLKDPRW 121 Query: 522 VRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQELTAD 701 HR++++PAF K + + + T + ++ + E + +Q T Sbjct: 122 SIHRKLLNPAFGH---KVLLSFLPIFNRETALLLDQLEPLQDDGE--KDLIPLLQSFTLG 176 Query: 702 IISHTAFGSSYKLGMEAFYAQKELQAIAISSLLNVQIPGFSYLPTKRNRRKWMLEKKLRS 881 I + T GS K + ++ +SLL F + + + ++R Sbjct: 177 IATQTTMGSDVK----------DEESFRSNSLLGRYQCRFCRQLAGKESHYYQAKTEIRQ 226 Query: 882 TLMRIINSRLASQGSG-----YGNDLLGLMLEGCTETEQGGKQEQLSLSMEEILHECKTF 1046 + +II +LA G ND L L T+ + G +++ + E Sbjct: 227 FIRKIIERKLAEDEMGALPSIQSNDK-NLFLNLVTDLMRRGV-----FTLKNVEDESNII 280 Query: 1047 FFAGYETTSLLLTWTVFLLSVYPEWQERLRAEV---LREVGKGDPSGDNLGKLKEMTMVL 1217 F +ETT+ + +T+ LL+++PE+QER E+ G D S + ++ + ++L Sbjct: 281 VFGAFETTANAVYYTLMLLAMFPEYQERAFEEIKTIFPNTGDFDVSYADTQQMVYLDLIL 340 Query: 1218 HETLRLYGPALFMQRKTTTDMVVG-AITIPKEHAIVIGAPFMHRDKKVWGEDADQFNPMR 1394 +E++R+ P + R+T+ D+ + I +PK I I MHR KK+WG DA+ FNP Sbjct: 341 NESMRVIPPVPVVSRQTSQDLKLSNGIVVPKGVQIAIDIYHMHRSKKIWGPDAETFNPDH 400 Query: 1395 FANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALS 1547 F + K P+A + F+ G R CIG +A++ AK +A +L+ + F S Sbjct: 401 FLPHNIQ-DKHPYAYIPFTKGIRNCIGWRYALISAKVTLAKLLRNYRFKTS 450
>Q5RCN6:CP4V2_PONPY Cytochrome P450 4V2 - Pongo pygmaeus (Orangutan)| Length = 525 Score = 108 bits (271), Expect = 6e-23 Identities = 122/492 (24%), Positives = 210/492 (42%), Gaps = 30/492 (6%) Frame = +3 Query: 243 VRRMKAETAHVVLHVRD-HDYLHRVAPHFLKWRAQYGEPFL-FWFGAKPRICVFDYELVR 416 V R H +L RD ++ ++ + ++R P L W G P + +++ E V Sbjct: 53 VARAYPLVGHALLMKRDGREFFQQIIEYTEEYRHM---PLLKLWVGPVPMVALYNAENVE 109 Query: 417 QILSSKSGHFPKNDAHPNXXXXXXXXXXXXXXXDWVRHRRVIDPAFAMDKIKAMTKTMVS 596 IL+S S K+ + W R+++ P F ++ M Sbjct: 110 VILTS-SRQIDKSSMYKFLEPWLGLGLLTSTGNKWRSRRKMLTPTFHFTILEDFLDIMNE 168 Query: 597 CAQSTFGVFEEQASKNTNKEIQVEFDKSVQELTADIISHTAFGSSYKLGMEAFYAQKELQ 776 A + ++ K+ N+E F + DII TA G + +G ++ + ++ Sbjct: 169 QAN----ILVKKLEKHVNQEAFNCFFY-ITLCALDIICETAMGKN--IGAQSNDDSEYVR 221 Query: 777 AIAISSLL---NVQIP----GFSYLPTKRNRRKWMLEKKLRSTLMRIINSRLASQGSGYG 935 A+ S + +++P YL K W EK L+ L N+ +A + + Sbjct: 222 AVYRMSQMIFQRIKMPWLWLDLWYLMFKEG---WEHEKGLK-ILHTFTNNVIAERANEMN 277 Query: 936 NDLLGLMLEGCTETEQGGK------------------QEQLSLSMEEILHECKTFFFAGY 1061 D E C +G E LS E+I E TF F G+ Sbjct: 278 AD------EDCRGVGRGSAPSKNKRRAFLDLLLSVTDDEGNRLSHEDIREEVDTFMFEGH 331 Query: 1062 ETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGKGD--PSGDNLGKLKEMTMVLHETLRL 1235 +TT+ + W+++LL PE Q+++ E+ GK D + ++L KL+ + V+ ETLRL Sbjct: 332 DTTAAAINWSLYLLGCNPEVQQKVDHELDDVFGKSDRPATVEDLKKLRYLECVIKETLRL 391 Query: 1236 YGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDADQFNPMRFANGVAR 1415 + R + D V + K VI +HRD + + + ++F P RF A+ Sbjct: 392 FPSVPLFARSVSEDCEVAGYRVLKGTEAVIIPYALHRDPRYF-PNPEEFQPERFFPENAQ 450 Query: 1416 AAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSPSYVHAPAD-FLTLRP 1592 + P+A + FS GPR CIGQ FA++E K++++ +L+ F + + L LRP Sbjct: 451 -GRHPYAYVPFSAGPRNCIGQKFAVMEEKTILSCILRHFWIESNQKREELGLEGQLILRP 509 Query: 1593 KFGLPVVMKLLD 1628 G+ + +K D Sbjct: 510 SNGIWIKLKRRD 521
>O23365:C97B3_ARATH Cytochrome P450 97B3 - Arabidopsis thaliana (Mouse-ear cress)| Length = 580 Score = 108 bits (271), Expect = 6e-23 Identities = 112/465 (24%), Positives = 184/465 (39%), Gaps = 61/465 (13%) Frame = +3 Query: 333 WRAQYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHFPKNDAHPNXXXXXXXXXXXXXX 512 W ++G + FG K + + D + R +L + + K Sbjct: 106 WFLEHGGIYKLAFGPKAFVVISDPIIARHVLRENAFSYDKGVLAEILEPIMGKGLIPADL 165 Query: 513 XDWVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTF----GVFEEQASKNTNKEIQVEFDKS 680 W RR I PAF ++AM K C++ + E+ + + I+++ + Sbjct: 166 DTWKLRRRAITPAFHKLYLEAMVKVFSDCSEKMILKSEKLIREKETSSGEDTIELDLEAE 225 Query: 681 VQELTADIISHTAFGSSYKLGMEAFYAQKELQAI--AISSLLNVQIPGFSYLPTKR-NRR 851 L DII + F +Y G KE I +L + Y P Sbjct: 226 FSSLALDIIGLSVF--NYDFGS----VTKESPVIKAVYGTLFEAEHRSTFYFPYWNFPPA 279 Query: 852 KWML--EKKLRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGGKQEQLS------ 1007 +W++ ++K +S L I ND L +++ ET Q E+L Sbjct: 280 RWIVPRQRKFQSDLKII-------------NDCLDGLIQNAKETRQETDVEKLQERDYTN 326 Query: 1008 -----------------LSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLR 1136 + ++ + T AG+ETT+ +LTW VFLLS PE + + Sbjct: 327 LKDASLLRFLVDMRGVDIDDRQLRDDLMTMLIAGHETTAAVLTWAVFLLSQNPEKIRKAQ 386 Query: 1137 AEVLREVGKGDPSGDNLGKLKEMTMVLHETLRLY-GPALFMQRKTTTDMVVG-------A 1292 AE+ +G+G P+ +++ KL+ + +++ E LRL+ P L ++R + + G Sbjct: 387 AEIDAVLGQGPPTYESMKKLEYIRLIVVEVLRLFPQPPLLIRRTLKPETLPGGHKGEKEG 446 Query: 1293 ITIPKEHAIVIGAPFMHRDKKVWGEDADQFNPMRF-----ANGV----------ARAAKV 1427 +PK I I +HR W D F P RF +NG+ + A Sbjct: 447 HKVPKGTDIFISVYNLHRSPYFWDNPHD-FEPERFLRTKESNGIEGWAGFDPSRSPGALY 505 Query: 1428 PH------ALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFAL 1544 P+ A L F GPR CIG FA++E+ +A + QKF L Sbjct: 506 PNEIIADFAFLPFGGGPRKCIGDQFALMESTVALAMLFQKFDVEL 550
>Q9V4U7:C6A14_DROME Probable cytochrome P450 6a14 - Drosophila melanogaster (Fruit fly)| Length = 509 Score = 108 bits (271), Expect = 6e-23 Identities = 101/410 (24%), Positives = 180/410 (43%), Gaps = 25/410 (6%) Frame = +3 Query: 393 VFDYELVRQILSSKSGHFPKNDAHPNXXXXXXXXXXXXXXXD-WVRHRRVIDPAFAMDKI 569 + D + ++Q++ +F A N + W R + P F KI Sbjct: 82 ITDLDFIKQVMIKDFSYFQDRGAFTNPRDDPLTGHLFALEGEEWRAMRHKLTPVFTSGKI 141 Query: 570 KAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQELTADIISHTAFGSSY----- 734 K M+K +V ++ + +E VE T D+I AFG Sbjct: 142 KQMSKVIVDVGLRLGDAMDKAVKEAKVEEGNVEIKDLCARFTTDVIGSCAFGLECNSLQD 201 Query: 735 ------KLGMEAFYAQKELQAIAISSLLNVQIPGFSYLPTKRNRRKWM---LEKKLRSTL 887 + G E F ++ + N ++ ++ R K + L + ST+ Sbjct: 202 PSAEFRQKGREIFTRRRHSTLVQSFIFTNARL-------ARKLRIKVLPDDLTQFFMSTV 254 Query: 888 MRIINSRLASQGSGYGNDLLGLMLEGCTETEQGGKQEQ-----LSLSMEEILHECKTFFF 1052 ++ RL + ND + M+E E ++ K+ Q L++E++ + FF Sbjct: 255 KNTVDYRL--KNGIKRNDFIEQMIELRAEDQEAAKKGQGIDLSHGLTLEQMAAQAFVFFV 312 Query: 1053 AGYETTSLLLTWTVFLLSVYPEWQERLRAE---VLREVGKGDPSGDNLGKLKEMTMVLHE 1223 AG+ET+S ++ ++ L++ P+ Q+RLR E VL V G+ + D L ++ + VL E Sbjct: 313 AGFETSSSTMSLCLYELALQPDIQQRLREEIESVLANVDGGELNYDVLAQMTYLDQVLSE 372 Query: 1224 TLRLYGPALFMQRKTTTDMVV--GAITIPKEHAIVIGAPFMHRDKKVWGEDADQFNPMRF 1397 TLR + + R+TT D + I + K +I +H D +++ E ++F+P RF Sbjct: 373 TLRKHPLLPHLIRETTKDYQIPNSDIVLDKGILALIPVHNIHHDPEIYPE-PEKFDPSRF 431 Query: 1398 ANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALS 1547 + + P A L F GPR CIG F ++AK + ++L++F F++S Sbjct: 432 DPEEVK-NRHPMAYLPFGDGPRNCIGLRFGKIQAKIGLVSLLRRFKFSVS 480
>Q64148:CP3AA_MESAU Cytochrome P450 3A10 - Mesocricetus auratus (Golden hamster)| Length = 503 Score = 108 bits (270), Expect = 8e-23 Identities = 106/419 (25%), Positives = 190/419 (45%), Gaps = 21/419 (5%) Frame = +3 Query: 342 QYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHFPKNDAHPNXXXXXXXXXXXXXXXDW 521 +YG+ + F+ G P + + D E+++ +L + N +W Sbjct: 67 KYGKIWGFYDGRVPVLAIADPEIIKTVLVKECYSNFTNRRSFGPVGFMKKSITISKDEEW 126 Query: 522 VRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQEL--- 692 R R ++ PAF K+K M + G + + KN +E + +++E+ Sbjct: 127 KRLRTLLSPAFTSGKLKEMFPII--------GQYGDTLVKNLRREEEKGKPVNMKEILGA 178 Query: 693 -TADIISHTAFG---------------SSYKLGMEAFYAQKELQAIAISSLLNV-QIPGF 821 + D+I+ T+FG + K+ F+ L I L + + F Sbjct: 179 YSMDVITGTSFGVNVDSLNNPEDPFVQKARKILKFNFFDPFILSIILFPFLTTIYDLLRF 238 Query: 822 SYLPTKRNRRKWMLEKKLRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGGKQEQ 1001 S P R+ KK +T+ + +RL S D LM+ T+ +G K+ Q Sbjct: 239 SIFP----RQSTNFFKKFITTMKK---NRLHSNQKTR-MDFFQLMMN--TQNSKG-KESQ 287 Query: 1002 LSLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREV-GKGDPSG 1178 +LS E+ + F FAGYE+TS + ++ L+ +P+ Q++L E+ + K + Sbjct: 288 KALSDLEMAAQAIIFIFAGYESTSTSICLVLYELATHPDVQKKLHDEIDSALPNKAPVTY 347 Query: 1179 DNLGKLKEMTMVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKV 1358 D L ++ + MV++E LRLY A ++R + + + + IPK +++ +HRD + Sbjct: 348 DVLMGMEYLDMVINEGLRLYPIANRLERISKKAVEINGLFIPKGITVMVPTYPLHRDPEY 407 Query: 1359 WGEDADQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFS 1535 W E ++F P RF+ + + P+ + F GPR CIG FA+L K + +VLQ F+ Sbjct: 408 WPE-PEEFRPERFSK-ENKGSIDPYVYMPFGNGPRNCIGMRFALLSMKLAVVSVLQNFT 464
>O09158:CP3AP_MOUSE Cytochrome P450 3A25 - Mus musculus (Mouse)| Length = 503 Score = 108 bits (269), Expect = 1e-22 Identities = 98/408 (24%), Positives = 182/408 (44%), Gaps = 10/408 (2%) Frame = +3 Query: 342 QYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHFPKNDAHPNXXXXXXXXXXXXXXXDW 521 +YG+ + F+ G +P + + D E+++ +L + N +W Sbjct: 67 KYGKIWGFYEGPQPILAIMDPEIIKIVLVKECYSVFTNRRFFGPVGFMKKAITISEDEEW 126 Query: 522 VRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQELTAD 701 R R ++ P F K+K M M + + K + + D Sbjct: 127 KRLRTLLSPTFTSGKLKEMFPIMRQYGD----ILVRNLRREEEKGEPISMKDIFGAYSMD 182 Query: 702 IISHTAFG---SSYKLGMEAFYAQ-KELQAIAISSLLNVQIPGFSYLPTKRNRRKWMLEK 869 +I+ T+FG S + F + K++ I + I F +L + + Sbjct: 183 VITGTSFGVNVDSLNNPQDPFVQKAKKILKFKIFDPFLLSIILFPFLTPIYEMLNFSIFP 242 Query: 870 K-----LRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGGKQEQLSLSMEEILHE 1034 + + + R+ RLAS D L LM+ T+ +G ++ Q +LS E+ + Sbjct: 243 RDSMNFFKKFVKRMKKERLASNQKNRV-DFLQLMMN--TQNSKG-QESQKALSDLEMAAQ 298 Query: 1035 CKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREV-GKGDPSGDNLGKLKEMTM 1211 F F GY+ TS ++ ++ L+ +P+ Q++L+ E+ R + K + D L ++ + M Sbjct: 299 AVIFIFGGYDATSTSISLIMYELATHPDVQKKLQDEIDRTLPNKAPVTYDALMDMEYLDM 358 Query: 1212 VLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDADQFNPM 1391 V++E+LRLY A+ ++R + D+ + + IPK ++I +HR+ + W E +F P Sbjct: 359 VVNESLRLYPIAIRLERVSKKDVEINGVFIPKGTVVMIPIYPLHRNPEYWPE-PQEFCPE 417 Query: 1392 RFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFS 1535 RF+ + P+ + F GPR CIG FA++ K + VLQ F+ Sbjct: 418 RFSK-ENKGNIDPYIYMPFGNGPRNCIGMRFALISIKLAVIGVLQNFT 464
>Q9V6H1:CP9H1_DROME Probable cytochrome P450 9h1 - Drosophila melanogaster (Fruit fly)| Length = 518 Score = 107 bits (268), Expect = 1e-22 Identities = 103/404 (25%), Positives = 180/404 (44%), Gaps = 24/404 (5%) Frame = +3 Query: 393 VFDYELVRQILSSKSGHFPKNDAHPNXXXXXXXXXXXXXXXD--WVRHRRVIDPAFAMDK 566 V D EL++ I + HF +++ N D W R ++ PAF K Sbjct: 86 VRDPELIKLIGIKEFDHFVNHNSMHNNIQESILSKSLISLRDGRWKEMRNILTPAFTGSK 145 Query: 567 IKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQELTADIISHTAFGSSY---- 734 ++ M + SC++ +EQ + + I++E D+I+ AFG S Sbjct: 146 MRIMYDLIQSCSEEGVIHIQEQLELSQDASIELEMKDYFTRFANDVIATVAFGISINSFR 205 Query: 735 KLGMEAFYAQKELQAIAISSLLNVQIPGFSYLP-TKRNRRKWMLEKKLRSTLMRIINS-- 905 + E F + + I+ S++ + ++ P + R +L+ K ++ + Sbjct: 206 RKDNEFFRIGQAMSRISAWSVVKAML--YALFPRLMKVLRIQVLDTKNIDYFSSLVTAAM 263 Query: 906 RLASQGSGYGNDLLGLMLEG----CTETEQGGKQE--QLSLSMEEILHECKTFFFAGYET 1067 R + D++ L++E + K E + +++L +C FFFAG+E Sbjct: 264 RYRQEHKVVRPDMIHLLMEAKQQRLADLSDKSKDELYYSEFTADDLLAQCLLFFFAGFEI 323 Query: 1068 TSLLLTWTVFLLSVYPEWQERLRAEVL--REVGKGDP-SGDNLGKLKEMTMVLHETLRLY 1238 S L + L + P Q+RL E++ E KG P + D L K+K + MV+ E LR + Sbjct: 324 ISSSLCFLTHELCLNPTVQDRLYEEIISVHEELKGQPLTYDKLTKMKYLDMVVLEALRKW 383 Query: 1239 GPALFMQRKTTTDMVV----GAITIPKEHAIVIGAPF--MHRDKKVWGEDADQFNPMRFA 1400 P++ R+ D+ + G V+ P +H D + + ED + FNP RFA Sbjct: 384 PPSISTDRECRQDIDLFDENGQKLFSARKGDVLQIPIFSLHHDPENF-EDPEFFNPERFA 442 Query: 1401 NGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKF 1532 +G A ++V + F +GPR CIG A++E KS++ +L F Sbjct: 443 DGHALESRV---YMPFGVGPRNCIGNRMALMELKSIVYQLLLNF 483
>Q9HB55:CP343_HUMAN Cytochrome P450 3A43 - Homo sapiens (Human)| Length = 503 Score = 107 bits (268), Expect = 1e-22 Identities = 98/409 (23%), Positives = 178/409 (43%), Gaps = 10/409 (2%) Frame = +3 Query: 342 QYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHFPKNDAHPNXXXXXXXXXXXXXXXDW 521 +YGE + + G +P + + D ++++ +L + N +W Sbjct: 67 KYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSFAEDEEW 126 Query: 522 VRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQELTAD 701 R R ++ PAF K K M + C ++A + + ++ F T D Sbjct: 127 KRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGA----YTMD 182 Query: 702 IISHTAFG---SSYKLGMEAFYAQ-KELQAIAISSLLNVQIPGFSYLPTKRNRRKWMLEK 869 +I+ T FG S + F K+L + + I F +L L Sbjct: 183 VITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGLFP 242 Query: 870 K-----LRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGGKQEQLSLSMEEILHE 1034 K L++++ R+ SRL + + D M++ E + +LS E++ + Sbjct: 243 KDVTHFLKNSIERMKESRLKDKQK-HRVDFFQQMIDSQNSKET---KSHKALSDLELVAQ 298 Query: 1035 CKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREV-GKGDPSGDNLGKLKEMTM 1211 FA Y+TTS L + ++ L+ +P+ Q++L+ E+ + K + D L +++ + M Sbjct: 299 SIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDM 358 Query: 1212 VLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDADQFNPM 1391 V++ETLRL+ + R D+ + + IPK A+++ +H D K W E ++F P Sbjct: 359 VVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTE-PEKFCPE 417 Query: 1392 RFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSF 1538 RF+ + + + + F GPR CIG FA+ K + LQ FSF Sbjct: 418 RFSKKNKDSIDL-YRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSF 465
>O48921:C97B2_SOYBN Cytochrome P450 97B2 - Glycine max (Soybean)| Length = 576 Score = 107 bits (268), Expect = 1e-22 Identities = 113/460 (24%), Positives = 188/460 (40%), Gaps = 56/460 (12%) Frame = +3 Query: 333 WRAQYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHFPKNDAHPNXXXXXXXXXXXXXX 512 W ++G + FG K + V D + R IL + + K Sbjct: 101 WFLEHGAVYKLAFGPKAFVVVSDPIVARHILRENAFSYDKGVLADILEPIMGKGLIPADL 160 Query: 513 XDWVRHRRVIDPAFAMDKIKAMTKTMVSCAQST---FGVFEEQASKNTNKEIQVEFDKSV 683 W + RRVI PAF ++AM K +C++ T F E + I+++ + Sbjct: 161 DTWKQRRRVIAPAFHNSYLEAMVKIFTTCSERTILKFNKLLEGEGYDGPDSIELDLEAEF 220 Query: 684 QELTADIISHTAFGSSYKLGMEAFYAQKELQAI--AISSLLNVQIPGFSYLPT-KRNRRK 854 L DII F +Y G KE I +L + Y+P K + Sbjct: 221 SSLALDIIGLGVF--NYDFGS----VTKESPVIKAVYGTLFEAEHRSTFYIPYWKIPLAR 274 Query: 855 WML--EKKLRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGGKQEQLSLSMEE-- 1022 W++ ++K + L ++IN+ L + L+ E ET+ Q++ L++++ Sbjct: 275 WIVPRQRKFQDDL-KVINTCL--------DGLIRNAKESRQETDVEKLQQRDYLNLKDAS 325 Query: 1023 -----------------ILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLR 1151 + + T AG+ETT+ +LTW VFLL+ P ++ +AEV Sbjct: 326 LLRFLVDMRGADVDDRQLRDDLMTMLIAGHETTAAVLTWAVFLLAQNPSKMKKAQAEVDL 385 Query: 1152 EVGKGDPSGDNLGKLKEMTMVLHETLRLY-GPALFMQRKTTTDMVVG-------AITIPK 1307 +G G P+ ++L +L+ + +++ E LRLY P L ++R +D++ G IP Sbjct: 386 VLGTGRPTFESLKELQYIRLIVVEALRLYPQPPLLIRRSLKSDVLPGGHKGEKDGYAIPA 445 Query: 1308 EHAIVIGAPFMHRDKKVWGEDADQFNPMRF-------------------ANGVARAAKV- 1427 + I +HR W + D F P RF + G +V Sbjct: 446 GTDVFISVYNLHRSPYFW-DRPDDFEPERFLVQNKNEEIEGWAGLDPSRSPGALYPNEVI 504 Query: 1428 -PHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFAL 1544 A L F GPR C+G FA++E+ + +LQ F L Sbjct: 505 SDFAFLPFGGGPRKCVGDQFALMESTVALTMLLQNFDVEL 544
>P49430:THAS_RAT Thromboxane-A synthase - Rattus norvegicus (Rat)| Length = 533 Score = 107 bits (266), Expect = 2e-22 Identities = 108/448 (24%), Positives = 181/448 (40%), Gaps = 40/448 (8%) Frame = +3 Query: 327 LKWRAQYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHFPKNDAHPNXXXXXXXXXXXX 506 L+ R +YG ++ G + I + D ++++++L +F A Sbjct: 68 LELRERYGPLCGYYLGRRMYIVISDPDMIKEVLVENFSNFSNRMASGLEPKLIADSVLML 127 Query: 507 XXXDWVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQ 686 W R + AF+ +K+ MT + + + A+ +IQ + Sbjct: 128 RDRRWEEVRGALMSAFSPEKLNEMTPLISQACELLLSHLKHSAASGDAFDIQ----RCYC 183 Query: 687 ELTADIISHTAFGSSYKLG-------------MEAFYAQKELQAIAISSLLNVQIPGFSY 827 T ++++ AFG + AF + L A+ I S ++ +P Sbjct: 184 CFTTNVVASVAFGIEVNSQDAPEDPFVQHCQRVFAFSTPRPLLAL-ILSFPSIMVPLARI 242 Query: 828 LPTKRN-----------------RRKWMLEKKLRSTLMRIINSRLASQGSGYGNDLLGLM 956 LP K R K E++ L +++++ + S G + ++ Sbjct: 243 LPNKNRDELNGFFNTLIRNVIALRDKQTAEERRGDFLQMVLDAQRSM--SSVGVEAFDMV 300 Query: 957 LEGCTETEQGGKQEQLS--------LSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVY 1112 E + E G Q L+++EI + F AG+E T+ L++ +LL+ + Sbjct: 301 TEALSSAECMGDPPQRCHPTSTAKPLTVDEIAGQAFLFLIAGHEITTNTLSFITYLLATH 360 Query: 1113 PEWQERLRAEVLREVGKGD-PSGDNLGK-LKEMTMVLHETLRLYGPALFMQRKTTTDMVV 1286 PE QERL EV + K P NL + L + MV+ ETLR+Y PA R+ D V Sbjct: 361 PECQERLLKEVDLFMEKHPAPEYCNLQEGLPYLDMVVAETLRMYPPAFRFTREAAQDCEV 420 Query: 1287 GAITIPKEHAIVIGAPFMHRDKKVWGEDADQFNPMRFANGVARAAKVPHALLAFSIGPRA 1466 IP + I +H D + W + + F+P RF AR + P L F GPR+ Sbjct: 421 LGQHIPAGSVLEIAVGALHHDPEHW-PNPETFDPERF-TAEARLQQKPFTYLPFGAGPRS 478 Query: 1467 CIGQNFAMLEAKSVMATVLQKFSFALSP 1550 C+G +L K + VL KF F P Sbjct: 479 CLGVRLGLLVVKLTLLQVLHKFRFEACP 506
>Q9DBW0:CP4V3_MOUSE Cytochrome P450 4V3 - Mus musculus (Mouse)| Length = 525 Score = 107 bits (266), Expect = 2e-22 Identities = 112/443 (25%), Positives = 194/443 (43%), Gaps = 25/443 (5%) Frame = +3 Query: 366 WFGAKPRICVFDYELVRQILSSKSGHFPKNDAHPNXXXXXXXXXXXXXXXDWVRHRRVID 545 W G P + ++ E V IL+S S K+ + W R+++ Sbjct: 93 WIGPVPLVALYKAENVEVILTS-SKQIDKSFLYKFLQPWLGLGLLTSTGSKWRTRRKMLT 151 Query: 546 PAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQELTADIISHTAFG 725 P F ++ M A + + K+ N+E F + DII TA G Sbjct: 152 PTFHFTILENFLDVMNEQAN----ILVNKLEKHVNQEAFNCFFY-ITLCALDIICETAMG 206 Query: 726 SSYKLGMEAFYAQKELQAI-AISSLL--NVQIP----GFSYLPTKRNRRKWMLEKKLRST 884 + +G ++ + ++ + +S ++ +++P YL K R K L + Sbjct: 207 KN--IGAQSNNDSEYVRTVYRMSDMIYRRMKMPWLWFDLWYLVFKEGRDHKRGLKCLHTF 264 Query: 885 LMRIINSRLASQ-------GSGYG--------NDLLGLMLEGCTETEQGGKQEQLSLSME 1019 +I R+ + G+G G L L+L E+G + LS E Sbjct: 265 TNNVIAERVKERKAEEDWTGAGRGPIPSKNKRKAFLDLLLS--VTDEEGNR-----LSQE 317 Query: 1020 EILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGKGDP--SGDNLGK 1193 +I E TF F G++TT+ + W+++LL PE Q ++ E+ G+ + ++L K Sbjct: 318 DIREEVDTFMFEGHDTTAAAINWSLYLLGTNPEVQRKVDQELDEVFGRSHRPVTLEDLKK 377 Query: 1194 LKEMTMVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDA 1373 LK + V+ ETLR++ R + D VG + K +I +HRD + + D Sbjct: 378 LKYLDCVIKETLRVFPSVPLFARSLSEDCEVGGYKVTKGTEAIIIPYALHRDPRYF-PDP 436 Query: 1374 DQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSPS 1553 ++F P RF ++ + P+A + FS GPR CIGQ FA++E K+++A +L++F + Sbjct: 437 EEFRPERFFPENSQG-RHPYAYVPFSAGPRNCIGQKFAVMEEKTILACILRQFWVESNQK 495 Query: 1554 YVH-APADFLTLRPKFGLPVVMK 1619 A L LRP G+ + +K Sbjct: 496 REELGLAGDLILRPNNGIWIKLK 518
>Q9V771:C6A23_DROME Probable cytochrome P450 6a23 - Drosophila melanogaster (Fruit fly)| Length = 502 Score = 107 bits (266), Expect = 2e-22 Identities = 116/409 (28%), Positives = 186/409 (45%), Gaps = 14/409 (3%) Frame = +3 Query: 363 FWFGAKPRICVFDYELVRQILSSKSGHFPKNDAHPNXXXXXXXXXXXXXXXDWVRH-RRV 539 F+F + D ELV+++L HF N RH R Sbjct: 73 FYFFFTRSAVITDLELVKRVLIKDFNHFENRGIFYNEIDDPLSATLFSIEGQKWRHLRHK 132 Query: 540 IDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQV-EFDKSVQELTADIISHT 716 + P F K+K M +V + +F ++K T E QV E V TAD+I + Sbjct: 133 LTPTFTSGKMKNMFPIIVKVGEEMEKIF---SAKTTTGEGQVLEIVDLVARYTADVIGNC 189 Query: 717 AFGSSYKL--GMEAFYAQKELQAIA---ISSLLNVQIPGFSYLPTKRNRRKWML---EKK 872 AFG + A + +AI LL+ I GF L ++R R K + E Sbjct: 190 AFGLNCNSLQNPNAEFVTIGKRAIIERRYGGLLDFLIFGFPKL-SRRLRLKLNVQDVEDF 248 Query: 873 LRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGGKQEQLSLSMEEILHECKTFFF 1052 S + I+ RL + + D + ++E E EQ G E LS EIL + FF Sbjct: 249 YTSIVRNTIDYRLRTNEKRH--DFMDSLIE-MYEKEQAGNTED-GLSFNEILAQAFIFFV 304 Query: 1053 AGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGK--GDPSGDNLGKLKEMTMVLHET 1226 AG+ET+S + + ++ L++ + Q++LRAE+ + K + + + + ++K + V+ ET Sbjct: 305 AGFETSSTTMGFALYELALDQDIQDQLRAEINNVLSKHNNEFTYEGIKEMKYLEQVVMET 364 Query: 1227 LRLYGPALFMQRKTTTDMVV--GAITIPKEHAIVIGAPFMHRDKKVWGEDADQFNPMRFA 1400 LR Y + R T TD I K +VI A +H D +++ E ++F P RF Sbjct: 365 LRKYPVLAHLTRMTQTDFSPEDPKYFIAKGTTVVIPALGIHYDPEIYPE-PEKFKPERFT 423 Query: 1401 NGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALS 1547 + A AA+ L F GPR CIG F +++A +A +++ + F++S Sbjct: 424 D-EAIAARPSCTWLPFGEGPRNCIGLRFGLMQACVGLAYLIRGYKFSVS 471
>Q27589:CP4D2_DROME Cytochrome P450 4d2 - Drosophila melanogaster (Fruit fly)| Length = 501 Score = 106 bits (264), Expect = 4e-22 Identities = 111/438 (25%), Positives = 181/438 (41%), Gaps = 26/438 (5%) Frame = +3 Query: 330 KWRAQYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHFPKNDAHPNXXXXXXXXXXXXX 509 K + +YG + W + + D + +LSS+ H KN+ + Sbjct: 60 KNQRKYGRLYRVWILHQLAVFSTDPRDIEFVLSSQQ-HITKNNLYKLLNCWLGDGLLMST 118 Query: 510 XXDWVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQE 689 W R++I P F + + V V EQ + + + + Sbjct: 119 GRKWHGRRKIITPTFHFK----ILEQFVEIFDQQSAVMVEQLQSRADGKTPINIFPVICL 174 Query: 690 LTADIISHTAFGSSYKLGMEAFYAQKELQ---AIAISSLLNVQIPGFSYL---------- 830 DII+ TA G+ AQK A++ + N+ I F + Sbjct: 175 TALDIIAETAMGTKIN-------AQKNPNLPYVQAVNDVTNILIKRFIHAWQRVDWIFRL 227 Query: 831 --PTKRNRRKWML-------EKKLRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQ 983 PT+ R+ + E +R ++N+ + N L + Sbjct: 228 TQPTEAKRQDKAIKVMHDFTENIIRERRETLVNNSKETTPEEEVNFLGQKRRMALLDVLL 287 Query: 984 GGKQEQLSLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAE---VLRE 1154 + LS E+I E TF F G++TT+ +++ ++ +S +PE Q+RL+ E VL E Sbjct: 288 QSTIDGAPLSDEDIREEVDTFMFEGHDTTTSAISFCLYEISRHPEVQQRLQQEIRDVLGE 347 Query: 1155 VGKGDPSGDNLGKLKEMTMVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAP 1334 K + +LG+LK M V+ E+LRL+ P + R D+ + IP +G Sbjct: 348 DRKSPVTLRDLGELKFMENVIKESLRLHPPVPMIGRWFAEDVEIRGKHIPAGTNFTMGIF 407 Query: 1335 FMHRDKKVWGEDADQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMA 1514 + RD + + E D+F P RF V + P+A + FS GPR CIGQ FAMLE KS ++ Sbjct: 408 VLLRDPEYF-ESPDEFRPERFDADVPQIH--PYAYIPFSAGPRNCIGQKFAMLEMKSTVS 464 Query: 1515 TVLQKFS-FALSPSYVHA 1565 +L+ F L P H+ Sbjct: 465 KLLRHFELLPLGPEPRHS 482
>Q64406:CP3AF_CAVPO Cytochrome P450 3A15 - Cavia porcellus (Guinea pig)| Length = 503 Score = 106 bits (264), Expect = 4e-22 Identities = 102/421 (24%), Positives = 183/421 (43%), Gaps = 17/421 (4%) Frame = +3 Query: 327 LKWRAQYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHFPKNDAHPNXXXXXXXXXXXX 506 ++ R +YG + + G +P + + + ++++ +L + N Sbjct: 62 IECRKKYGNMWGLYDGPQPVLAITEPDMIKAVLVKECYSVFTNRRSLVPVGFMKKSVSLS 121 Query: 507 XXXDWVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQ 686 +W R R + P F K+K M + ++A K +++ F Sbjct: 122 EDEEWKRIRTQLSPNFTSGKLKEMFPIIKQYGDVLVKNLRQEAEKGKPVQLKEIFGA--- 178 Query: 687 ELTADIISHTAFG---------------SSYKLGMEAFYAQKELQAIAISSLLNV-QIPG 818 DII TAFG + KL F + L + L + ++ Sbjct: 179 -YGMDIIIATAFGVNVDSLNNPHDPFVSKANKLFRFDFLSPFLLSTVMFPFLTQLYEMLS 237 Query: 819 FSYLPTKRNRRKWMLEKKLRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGGKQE 998 S P R+ K+ K ++ T + S + + L +ML + + Sbjct: 238 ISIFP--RDSLKFFT-KFVKKTKENHLESNKKQRVN-----FLQMMLNSQNFKDT---ES 286 Query: 999 QLSLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREV-GKGDPS 1175 +LS EIL + F FAGYET+S L+ ++ L+ +P+ Q++L E+ + + K P+ Sbjct: 287 HKALSDVEILAQSIIFIFAGYETSSSTLSCIMYSLATHPDVQKKLHQEIDKTLPNKAFPT 346 Query: 1176 GDNLGKLKEMTMVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKK 1355 D + +++ + MV++ETLRLY A ++R + D + ++ PK ++I + +HRD K Sbjct: 347 YDVMMEMEYLDMVVNETLRLYPVANRIERMSKKDFEINGMSFPKGTLVMIPSFALHRDSK 406 Query: 1356 VWGEDADQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFS 1535 W E D+F P RF+ P+ + F GPR CIG+ A++ K + +LQ FS Sbjct: 407 YWPE-PDEFRPERFSKKNKENID-PYIYMPFGNGPRNCIGRRMALMNLKLALIRLLQNFS 464 Query: 1536 F 1538 F Sbjct: 465 F 465
>P30437:CP17A_ONCMY Cytochrome P450 17A1 - Oncorhynchus mykiss (Rainbow trout) (Salmo| gairdneri) Length = 514 Score = 105 bits (263), Expect = 5e-22 Identities = 105/434 (24%), Positives = 181/434 (41%), Gaps = 22/434 (5%) Frame = +3 Query: 315 APH--FLKWRAQYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHF---PKNDAHPNXXX 479 APH F K + +YG + G I V ++ +++L K F P+ Sbjct: 54 APHVLFQKLQQKYGHTYSLMMGPHTVILVNHHQHAKEVLLKKGKIFAGRPRTVTTDLLTR 113 Query: 480 XXXXXXXXXXXXDWVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEI 659 W HR+ + A M + + + C ++ + S + + ++ Sbjct: 114 DGKDIAFADYGATWRFHRKTVHGALCMFGEGSASIEKIICREALSLCDTLRESGSASLDL 173 Query: 660 QVEFDKSVQELTADIISHTAFGSSYKLGMEAF-----YAQKELQAIAISSLLNVQIPGFS 824 E ++V +++ F SSY G F ++Q + +A SL+++ P Sbjct: 174 SPELTRAV----TNVVCSLCFSSSYCRGDPEFEAMLQFSQGIVDTVAKDSLVDI-FPWLQ 228 Query: 825 YLPTKRNRRKWMLEKKLRSTLMRIINSRLASQGSGYGN----DLLGLMLEGCTETEQGGK 992 P R L K+ S +++ + S Y + DLL +L E Sbjct: 229 VFPNADLR----LLKQCVSIRDKLLQKKYEEHKSDYSDHEQRDLLDALLRAKRSAENNNT 284 Query: 993 ----QEQLSLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVG 1160 E + LS + +L F AG ETTS +L W + L +P+ Q+R++ E+ VG Sbjct: 285 AEITMETVGLSEDHLLMTVGDIFGAGVETTSTVLKWAIAYLIHHPQVQQRIQEELDSVVG 344 Query: 1161 KGD--PSGDNLGKLKEMTMVLHETLRLYGPA-LFMQRKTTTDMVVGAITIPKEHAIVIGA 1331 GD P + G L + + E LR+ A L + TD +G T+ K I+I Sbjct: 345 -GDRTPQLSDRGSLPYLEATIREVLRIRPVAPLLIPHVAQTDTSIGKFTVRKGARIIINL 403 Query: 1332 PFMHRDKKVWGEDADQFNPMRFANGVARAAKVPH-ALLAFSIGPRACIGQNFAMLEAKSV 1508 +H D+K W ++ + F+P RF N +P + L F G R C+G+ A +E Sbjct: 404 WSLHHDEKEW-KNPEMFDPGRFLNEEGTGLCIPSPSYLPFGAGVRVCLGEALAKMEIFLF 462 Query: 1509 MATVLQKFSFALSP 1550 ++ +LQ+ + +SP Sbjct: 463 LSWILQRLTMTVSP 476
>Q6ZWL3:CP4V2_HUMAN Cytochrome P450 4V2 - Homo sapiens (Human)| Length = 525 Score = 105 bits (262), Expect = 7e-22 Identities = 115/447 (25%), Positives = 198/447 (44%), Gaps = 29/447 (6%) Frame = +3 Query: 366 WFGAKPRICVFDYELVRQILSSKSGHFPKNDAHPNXXXXXXXXXXXXXXXDWVRHRRVID 545 W G P + +++ E V IL+S S K+ + W R+++ Sbjct: 93 WVGPVPMVALYNAENVEVILTS-SKQIDKSSMYKFLEPWLGLGLLTSTGNKWRSRRKMLT 151 Query: 546 PAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQELTADIISHTAFG 725 P F ++ M A + ++ K+ N+E F + DII TA G Sbjct: 152 PTFHFTILEDFLDIMNEQAN----ILVKKLEKHINQEAFNCFFY-ITLCALDIICETAMG 206 Query: 726 SSYKLGMEAFYAQKELQAIAISSLL---NVQIP----GFSYLPTKRNRRKWMLEKKLRST 884 + +G ++ + ++A+ S + +++P YL K W +K L+ Sbjct: 207 KN--IGAQSNDDSEYVRAVYRMSEMIFRRIKMPWLWLDLWYLMFKEG---WEHKKSLK-I 260 Query: 885 LMRIINSRLASQ-----------GSGYGND--------LLGLMLEGCTETEQGGKQEQLS 1007 L NS +A + G G G+ L L+L + T+ G + Sbjct: 261 LHTFTNSVIAERANEMNANEDCRGDGRGSAPSKNKRRAFLDLLL---SVTDDEGNR---- 313 Query: 1008 LSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGKGD--PSGD 1181 LS E+I E TF F G++TT+ + W+++LL PE Q+++ E+ GK D + + Sbjct: 314 LSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHELDDVFGKSDRPATVE 373 Query: 1182 NLGKLKEMTMVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVW 1361 +L KL+ + V+ ETLRL+ R + D V + K VI +HRD + + Sbjct: 374 DLKKLRYLECVIKETLRLFPSVPLFARSVSEDCEVAGYRVLKGTEAVIIPYALHRDPRYF 433 Query: 1362 GEDADQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFA 1541 + ++F P RF A+ + P+A + FS GPR CIGQ FA++E K++++ +L+ F Sbjct: 434 -PNPEEFQPERFFPENAQ-GRHPYAYVPFSAGPRNCIGQKFAVMEEKTILSCILRHFWIE 491 Query: 1542 LSPSYVHAPAD-FLTLRPKFGLPVVMK 1619 + + L LRP G+ + +K Sbjct: 492 SNQKREELGLEGQLILRPSNGIWIKLK 518
>Q6VVX0:CP2R1_HUMAN Cytochrome P450 2R1 - Homo sapiens (Human)| Length = 501 Score = 105 bits (262), Expect = 7e-22 Identities = 111/449 (24%), Positives = 190/449 (42%), Gaps = 20/449 (4%) Frame = +3 Query: 318 PH-FLKWRAQ-YGEPFLFWFGAKPRICVFDYELVRQILSSKSGHFPKNDAHP--NXXXXX 485 PH +++ ++Q YGE F G + + Y++V++ L +S F P Sbjct: 62 PHVYMRKQSQVYGEIFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKM 121 Query: 486 XXXXXXXXXXDWVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFG--VFEEQASKN----T 647 WV HRR+ +F Q +F + EE N T Sbjct: 122 GGLLNSRYGRGWVDHRRLAVNSFRY----------FGYGQKSFESKILEETKFFNDAIET 171 Query: 648 NKEIQVEFDKSVQELTADIISHTAFG-------SSYKLGMEAFYAQKELQAIAISSLLNV 806 K +F + + ++I + FG + ++ +E F EL A A L N Sbjct: 172 YKGRPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNA 231 Query: 807 QIPGFSYLPTKRNRRKWMLEKKLRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQG 986 P LP ++++ + + L R+I ++ + L+ E +QG Sbjct: 232 -FPWIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLD---EMDQG 287 Query: 987 GKQEQLSLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVG-K 1163 + S E ++ AG ETT+ +L W + +++YP Q +++ E+ +G Sbjct: 288 KNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPN 347 Query: 1164 GDPSGDNLGKLKEMTMVLHETLRLYG-PALFMQRKTTTDMVVGAITIPKEHAIVIGAPFM 1340 G PS D+ K+ VLHE LR L + T+ D VV +IPK ++ + Sbjct: 348 GKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSV 407 Query: 1341 HRDKKVWGEDADQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATV 1520 H D+K W D + F+P RF + AK AL+ FS+G R C+G++ A +E + Sbjct: 408 HFDEKYW-RDPEVFHPERFLDSSGYFAK-KEALVPFSLGRRHCLGEHLARMEMFLFFTAL 465 Query: 1521 LQKFSFALSPSYVHAPADFL-TLRPKFGL 1604 LQ+F ++H P + + L+P+ G+ Sbjct: 466 LQRF-------HLHFPHELVPDLKPRLGM 487
>Q8HYN1:CP17A_PANTR Cytochrome P450 17A1 - Pan troglodytes (Chimpanzee)| Length = 508 Score = 105 bits (262), Expect = 7e-22 Identities = 112/463 (24%), Positives = 190/463 (41%), Gaps = 18/463 (3%) Frame = +3 Query: 294 HDYLHRVAPHFLKWRAQYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHF---PKNDAH 464 H ++H +F K + +YG + G K + V ++L +++L K F P+ Sbjct: 46 HGHMHN---NFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATL 102 Query: 465 PNXXXXXXXXXXXXXXXDWVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKN 644 W HRR+ FA+ K + C + + + + Sbjct: 103 DIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIICQE--ISTLCDMLATH 160 Query: 645 TNKEIQVEFDKSVQELTADIISHTAFGSSYKLGMEAF-----YAQKELQAIAISSLLNVQ 809 + I + F V ++IS F +SYK G Y + + ++ SL+++ Sbjct: 161 NGQSIDISFPVFVA--VTNVISLICFNTSYKNGDPELNIIQNYNEGIIDNLSKDSLVDL- 217 Query: 810 IPGFSYLPTKRNRRKWMLEKKLRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQ-- 983 +P P K K K+R+ L+ N L + + +D + ML+ + + Sbjct: 218 VPWLKIFPNK-TLEKLKSHVKIRNDLL---NKILENYKEKFRSDSITNMLDTLMQAKMNS 273 Query: 984 -----GGKQEQLSLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVL 1148 G Q+ LS IL F AG ETT+ ++ WT+ L P+ +++L E+ Sbjct: 274 DNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEID 333 Query: 1149 REVG-KGDPSGDNLGKLKEMTMVLHETLRLYGPA-LFMQRKTTTDMVVGAITIPKEHAIV 1322 + VG P+ + +L + + E LRL A + + K D +G + K ++ Sbjct: 334 QNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTQVI 393 Query: 1323 IGAPFMHRDKKVWGEDADQFNPMRFANGVARAAKVPH-ALLAFSIGPRACIGQNFAMLEA 1499 I +H ++K W DQF P RF N P + L F GPR+CIG+ A E Sbjct: 394 INLWALHHNEKEW-HQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQEL 452 Query: 1500 KSVMATVLQKFSFALSPSYVHAPADFLTLRPKFGLPVVMKLLD 1628 +MA +LQ+F + D L G+P V+ L+D Sbjct: 453 FLIMAWLLQRFDLEV--------PDDGQLPSLEGIPKVVFLID 487
>P05093:CP17A_HUMAN Cytochrome P450 17A1 - Homo sapiens (Human)| Length = 508 Score = 105 bits (262), Expect = 7e-22 Identities = 112/463 (24%), Positives = 190/463 (41%), Gaps = 18/463 (3%) Frame = +3 Query: 294 HDYLHRVAPHFLKWRAQYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHF---PKNDAH 464 H ++H +F K + +YG + G K + V ++L +++L K F P+ Sbjct: 46 HGHMHN---NFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATL 102 Query: 465 PNXXXXXXXXXXXXXXXDWVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKN 644 W HRR+ FA+ K + C + + + + Sbjct: 103 DIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIICQE--ISTLCDMLATH 160 Query: 645 TNKEIQVEFDKSVQELTADIISHTAFGSSYKLGMEAF-----YAQKELQAIAISSLLNVQ 809 + I + F V ++IS F +SYK G Y + + ++ SL+++ Sbjct: 161 NGQSIDISFPVFVA--VTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDL- 217 Query: 810 IPGFSYLPTKRNRRKWMLEKKLRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQ-- 983 +P P K K K+R+ L+ N L + + +D + ML+ + + Sbjct: 218 VPWLKIFPNK-TLEKLKSHVKIRNDLL---NKILENYKEKFRSDSITNMLDTLMQAKMNS 273 Query: 984 -----GGKQEQLSLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVL 1148 G Q+ LS IL F AG ETT+ ++ WT+ L P+ +++L E+ Sbjct: 274 DNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEID 333 Query: 1149 REVG-KGDPSGDNLGKLKEMTMVLHETLRLYGPA-LFMQRKTTTDMVVGAITIPKEHAIV 1322 + VG P+ + +L + + E LRL A + + K D +G + K ++ Sbjct: 334 QNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVI 393 Query: 1323 IGAPFMHRDKKVWGEDADQFNPMRFANGVARAAKVPH-ALLAFSIGPRACIGQNFAMLEA 1499 I +H ++K W DQF P RF N P + L F GPR+CIG+ A E Sbjct: 394 INLWALHHNEKEW-HQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQEL 452 Query: 1500 KSVMATVLQKFSFALSPSYVHAPADFLTLRPKFGLPVVMKLLD 1628 +MA +LQ+F + D L G+P V+ L+D Sbjct: 453 FLIMAWLLQRFDLEV--------PDDGQLPSLEGIPKVVFLID 487
>Q9VFJ0:CP131_DROME Probable cytochrome P450 313a1 - Drosophila melanogaster (Fruit fly)| Length = 492 Score = 104 bits (259), Expect = 1e-21 Identities = 99/423 (23%), Positives = 171/423 (40%), Gaps = 14/423 (3%) Frame = +3 Query: 330 KWRAQYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHFPKNDAHPNXXXXXXXXXXXXX 509 K+ +YG L W G P I D ++V I SS H Sbjct: 60 KYLNKYGSTILTWMGPVPFIVTRDPKVVEDIFSSPDCHNKSQHIVNAITSCMGNGLLGKQ 119 Query: 510 XXDWVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQE 689 W+ R+ +P+F D + + + + + + K +++ + Sbjct: 120 DPHWLDRRKHFNPSFKQDLLLSFFHIFDAETKVLMNLLDTYVDKG-----EIDVVPEMLR 174 Query: 690 LTADIISHTAFGSSYKLG--MEAFYAQKELQAIAISSLLNVQIPGFSYLPTKRNRRKWML 863 + I + T GS K + + +++ S LN+ +P L R K Sbjct: 175 WSFKIAAQTTMGSEVKHDEHFKNGSLVESFESLISHSTLNILMP----LVQNRMISKICG 230 Query: 864 EKKLRS--------TLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGGKQEQLSLSME 1019 KLR+ L ++N ++ + +++ E + G ++ Sbjct: 231 YDKLRADNFSRIQKMLDNVVNKKVNPLPKTDSDPESNIVINRAMELYRKG-----DITYM 285 Query: 1020 EILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAE---VLREVGKGDPSGDNLG 1190 ++ EC AGY+T++L + +FLL+ +PE QE + E V + G + ++ Sbjct: 286 DVKSECCIMIAAGYDTSALTVYHALFLLANHPEHQEAVFEELNGVFPDAGHFGITYPDMQ 345 Query: 1191 KLKEMTMVLHETLRLYGPALFMQRKTTTDM-VVGAITIPKEHAIVIGAPFMHRDKKVWGE 1367 KL + V+ ETLRL R+T D+ + + IPK I I HR+ +VWG Sbjct: 346 KLDYLERVIKETLRLIPAIPITARETKNDVRLSNGVLIPKGVVIGIDMFHTHRNPEVWGP 405 Query: 1368 DADQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALS 1547 DAD FNP F K P+A + F+ G R CIG +AM+ +K + +L+ + + S Sbjct: 406 DADNFNPDNFL-AENMEQKHPYAYIPFARGKRNCIGSKYAMMSSKFALCRILRNYKISTS 464 Query: 1548 PSY 1556 Y Sbjct: 465 TLY 467
>P36423:THAS_MOUSE Thromboxane-A synthase - Mus musculus (Mouse)| Length = 533 Score = 103 bits (258), Expect = 2e-21 Identities = 103/445 (23%), Positives = 184/445 (41%), Gaps = 37/445 (8%) Frame = +3 Query: 327 LKWRAQYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHFPKNDAHPNXXXXXXXXXXXX 506 L+ R +YG ++ G + + + + ++++Q+L +F A Sbjct: 68 LELRERYGPLCGYYLGRRMHVVISEPDMIKQVLVENFSNFSNRMASGLEPKMVADSVLLL 127 Query: 507 XXXDWVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQ 686 W R + +F+ +K+ MT + + + A+ IQ + Sbjct: 128 RDRRWEEVRGALMSSFSPEKLDEMTPLISQACELLVAHLKRYAASRDAFNIQ----RCYC 183 Query: 687 ELTADIISHTAFGSSY--KLGMEAFYAQKELQA----------IAISSLLNVQIPGFSYL 830 T D+++ AFG+ + E + Q +A + I S ++ +P L Sbjct: 184 CYTIDVVASVAFGTQVDSQNSPEDPFVQHCRRASTFCIPRPLLVLILSFPSIMVPLARIL 243 Query: 831 PTKRN-----------------RRKWMLEKKLRSTLMRIINSRLASQGSGY-GNDLLGLM 956 P K R + E++ R L +++++ + G G D++ Sbjct: 244 PNKNRDELNGFFNTLIRNVIALRDQQAAEERRRDFLQMVLDAQHSMNSVGVEGFDMVPES 303 Query: 957 LEGCTETEQGGKQ-----EQLSLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEW 1121 L T++ ++ +++EI+ + F AG+E + L++ +LL+ +P+ Sbjct: 304 LSSSECTKEPPQRCHPTSTSKPFTVDEIVGQAFLFLIAGHEVITNTLSFITYLLATHPDC 363 Query: 1122 QERLRAEVLREVGKGD-PSGDNLGK-LKEMTMVLHETLRLYGPALFMQRKTTTDMVVGAI 1295 QERL EV +GK P +L + L + MV+ ETLR+Y PA R+ D V Sbjct: 364 QERLLKEVDLFMGKHPAPEYHSLQEGLPYLDMVISETLRMYPPAFRFTREAAQDCEVLGQ 423 Query: 1296 TIPKEHAIVIGAPFMHRDKKVWGEDADQFNPMRFANGVARAAKVPHALLAFSIGPRACIG 1475 IP + I +H D + W + + F+P RF AR + P L F GPR+C+G Sbjct: 424 RIPAGTVLEIAVGALHHDPEHW-PNPETFDPERFT-AEARLQRRPFTYLPFGAGPRSCLG 481 Query: 1476 QNFAMLEAKSVMATVLQKFSFALSP 1550 +L K + VL KF F SP Sbjct: 482 VRLGLLVVKLTILQVLHKFRFEASP 506
>Q27594:CP6A9_DROME Cytochrome P450 6a9 - Drosophila melanogaster (Fruit fly)| Length = 504 Score = 103 bits (258), Expect = 2e-21 Identities = 105/419 (25%), Positives = 183/419 (43%), Gaps = 25/419 (5%) Frame = +3 Query: 363 FWFGAKPRICVFDYELVRQILSSKSGHFPKNDAHPNXXXXXXXXXXXXXXXD-WVRHRRV 539 +WF +P I V D L + IL + F + N W R Sbjct: 76 YWF-QRPGILVLDISLAKLILIKEFNKFTDRGFYHNTEDDPLSGQLFLLDGQKWKSMRSK 134 Query: 540 IDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQELTADIISHTA 719 + F K+K M T+V VF + K+ E++ + T D+I A Sbjct: 135 LSYTFTSGKMKYMFPTVVKVGHEFIEVFGQAMEKSPIVEVR----DILARFTTDVIGTCA 190 Query: 720 FG---SSYK--------LGMEAFYAQKE--LQAIAISSLLNVQIPGFSYLPTKRNRRKWM 860 FG SS K +G A + Q+ + I+S N+ +R K Sbjct: 191 FGIECSSLKDPEAEFRVMGRRAIFEQRHGPIGIAFINSFQNL---------ARRLHMKIT 241 Query: 861 LEKKLRSTLMRIINSRLASQGSG------YGNDLLGLMLEGCTETEQGGKQEQLSLSMEE 1022 LE+ +RI+ +A + + + L+ L T++E G E ++L++EE Sbjct: 242 LEEA-EHFFLRIVRETVAFREKNNIRRNDFMDQLIDLKNSPLTKSESG---ESVNLTIEE 297 Query: 1023 ILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGK--GDPSGDNLGKL 1196 + + FF AG+ET+S + + ++ L+ + + Q+R+R E +GK G+ + +++ + Sbjct: 298 MAAQAFVFFGAGFETSSTTMGFALYELAQHQDIQDRVRKECQEVIGKYNGEITYESMKDM 357 Query: 1197 KEMTMVLHETLRLYGPALFMQRKTTTDMVVGA---ITIPKEHAIVIGAPFMHRDKKVWGE 1367 + V+ ETLRLY + R+ D V I K ++I MHRD+K++ Sbjct: 358 VYLDQVISETLRLYTVLPVLNRECLEDYEVPGHPKYVIKKGMPVLIPCGAMHRDEKLYA- 416 Query: 1368 DADQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFAL 1544 + + FNP F+ + + L F GPR CIG F ++A+S +A ++ +F F++ Sbjct: 417 NPNTFNPDNFSPERVK-ERDSVEWLPFGDGPRNCIGMRFGQMQARSGLALLINRFKFSV 474
>Q9Y8G7:C505_FUSOX Bifunctional P-450:NADPH-P450 reductase - Fusarium oxysporum| Length = 1066 Score = 103 bits (258), Expect = 2e-21 Identities = 117/426 (27%), Positives = 177/426 (41%), Gaps = 10/426 (2%) Frame = +3 Query: 345 YGEPFLFWFGAKPRICVFDYELVRQILSSKSGHFPKND----AHPNXXXXXXXXXXXXXX 512 YG F GAK I V L+ ++ K F K + Sbjct: 37 YGPIFRLRLGAKAPIFVSSNSLINEVCDEK--RFKKTLKSVLSQVREGVHDGLFTAFEDE 94 Query: 513 XDWVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQEL 692 +W + R++ PAF I+ M M A F + T + F + + Sbjct: 95 PNWGKAHRILVPAFGPLSIRGMFPEMHDIATQLCMKFARHGPR-TPIDTSDNFTRLALDT 153 Query: 693 TADIISHTAFGSSYKLGMEAFYAQKELQAIAISSLLNVQIPGFS--YLPTKRNRRKWMLE 866 A F S YK + F + + S + P F+ +L N + + Sbjct: 154 LALCAMDFRFYSYYKEELHPFI--EAMGDFLTESGNRNRRPPFAPNFLYRAANEKFYGDI 211 Query: 867 KKLRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGGKQEQLSLSMEEILHECKTF 1046 ++S ++ +R AS DLL ML G + + G K LS E I ++ TF Sbjct: 212 ALMKSVADEVVAARKASPSDR--KDLLAAMLNG-VDPQTGEK-----LSDENITNQLITF 263 Query: 1047 FFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGKGDPSGDNLGKLKEMTMVLHET 1226 AG+ETTS L++ ++ L PE +++ EV VG+G ++L KL ++ VL ET Sbjct: 264 LIAGHETTSGTLSFAMYQLLKNPEAYSKVQKEVDEVVGRGPVLVEHLTKLPYISAVLRET 323 Query: 1227 LRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFM-HRDKKVWGEDADQFNPMRFAN 1403 LRL P + D +G + K+ IV H D V+G DAD+F P R + Sbjct: 324 LRLNSPITAFGLEAIDDTFLGGKYLVKKGEIVTALLSRGHVDPVVYGNDADKFIPERMLD 383 Query: 1404 G-VARAAK-VPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALS-PSYVHAPAD 1574 AR K P+ F G RACIG+ FA E+ M + Q F+F ++ P+Y Sbjct: 384 DEFARLNKEYPNCWKPFGNGKRACIGRPFAWQESLLAMVVLFQNFNFTMTDPNYALEIKQ 443 Query: 1575 FLTLRP 1592 LT++P Sbjct: 444 TLTIKP 449
>Q64409:CP3AH_CAVPO Cytochrome P450 3A17 - Cavia porcellus (Guinea pig)| Length = 503 Score = 103 bits (257), Expect = 2e-21 Identities = 61/179 (34%), Positives = 101/179 (56%), Gaps = 1/179 (0%) Frame = +3 Query: 1005 SLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREV-GKGDPSGD 1181 +LS EIL + F AGYETTS L + ++ L+ +P+ Q++L+ E+ + + K P+ D Sbjct: 289 ALSDVEILAQSIFFIVAGYETTSSTLCFIMYSLATHPDVQKKLQQEIDKTLPNKAFPTYD 348 Query: 1182 NLGKLKEMTMVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVW 1361 + +++ + MV++ETLRLY ++R + D + ++ PK ++I + +HRD K W Sbjct: 349 VMMEMEYLDMVVNETLRLYPVTNRIERMSKKDFEINGMSFPKGTGVMIPSFALHRDSKYW 408 Query: 1362 GEDADQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSF 1538 E D+F P RF+ P+ + F GPR CIG A++ K + +LQ FSF Sbjct: 409 PE-PDEFRPERFSKKNKENID-PYIYMPFGNGPRNCIGMRMALMNLKLALIRLLQNFSF 465
>Q964T2:CP9E2_BLAGE Cytochrome P450 9e2 - Blattella germanica (German cockroach)| Length = 533 Score = 103 bits (256), Expect = 3e-21 Identities = 97/370 (26%), Positives = 166/370 (44%), Gaps = 31/370 (8%) Frame = +3 Query: 519 WVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQ------------ 662 W R + PAF K+K M + C + G F + S++ NK+ + Sbjct: 132 WKEMRSTLSPAFTSSKMKNMFVLVSECGKQ-LGEFLMECSRDKNKKTEGCKIEREGDLLT 190 Query: 663 VEFDKSVQELTADIISHTAFG---SSYKLGMEAFYAQKELQAIAISSLLNVQIPGFSYLP 833 VE T D+I+ +AFG S K F+ Q + G+ + P Sbjct: 191 VELKDLYTRYTNDVIATSAFGIGCDSLKNPKNEFF-QMGKDVTNFGGIRQFIFLGYLFSP 249 Query: 834 T--KRNRRKWMLEKKLRSTLMRIINSRLASQGSGYGN-DLLGLML---EGCTETEQGGKQ 995 K K++ K + N+ + G D++ L++ EG ++E+ G+ Sbjct: 250 RLMKYLNLKFLSSKATEFFRFLVHNTMDTRKTKGIIRPDMIHLLMQAKEGTLKSEENGET 309 Query: 996 EQLSLSM-----EEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLR--E 1154 S +++ + FFFAG++T S LL + LL+ P+ Q RL+ E+ + E Sbjct: 310 NGKIASKPKWDDDDLTAQAVLFFFAGFDTASTLLCFMSHLLATNPDVQNRLQDEIDQSLE 369 Query: 1155 VGKGDPSGDNLGKLKEMTMVLHETLRLYGPALFMQRKTTTDM---VVGAITIPKEHAIVI 1325 G + + + +K + MV+ E+LRLY PA+F RK + + + T+ A+ I Sbjct: 370 ENDGKLTYEAIHSMKYLDMVVSESLRLYPPAIFTDRKCVKNYRLPMEPSYTLEPGDAVWI 429 Query: 1326 GAPFMHRDKKVWGEDADQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKS 1505 +H D K + + ++F+P RF++ K P L F GPR CIG FA++E+K Sbjct: 430 PIYAIHHDPKYY-PNPEKFDPERFSDENKDNIK-PFTYLPFGSGPRNCIGNRFALMESKI 487 Query: 1506 VMATVLQKFS 1535 + +L +F+ Sbjct: 488 ALVHLLCRFN 497
>P12394:CP17A_CHICK Cytochrome P450 17A1 - Gallus gallus (Chicken)| Length = 508 Score = 102 bits (255), Expect = 4e-21 Identities = 104/423 (24%), Positives = 185/423 (43%), Gaps = 18/423 (4%) Frame = +3 Query: 321 HFLKWRAQ--YGEPFLFWFGAKPRICVFDYELVRQILSSKSGHF---PKNDAHPNXXXXX 485 H WR Q YG + W G+ + V Y+ R++L K F P+ Sbjct: 55 HLRLWRLQGRYGSLYGLWMGSHYVVVVNSYQHAREVLLKKGKAFAGRPRTVTTDLLSRGG 114 Query: 486 XXXXXXXXXXDWVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQV 665 W R+++ A +M ++ + C ++ A+++ ++ Sbjct: 115 KDIAFASYGPLWKFQRKLVHAALSMFGEGSVALEKIICREAASLCETLGAAQDMALDMAP 174 Query: 666 EFDKSVQELTADIISHTAFGSSYKLGMEAF-----YAQKELQAIAISSLLNVQIPGFSYL 830 E ++V +++ F SSY+ G F Y+Q + +A SL+++ F +L Sbjct: 175 ELTRAV----TNVVCSLCFNSSYRRGDPEFEAMLEYSQGIVDTVAKESLVDI----FPWL 226 Query: 831 PTKRNRRKWMLEK--KLRSTLM--RIINSRLASQGSGYGNDLLGLMLEGCTETEQGGKQE 998 NR +L++ K+R L+ + + A G DL+ +L+ E E Sbjct: 227 QIFPNRDLALLKRCLKVRDQLLQQKFTEHKEAFCGDTV-RDLMDALLQVRLNAENNSPLE 285 Query: 999 Q-LSLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGKG-DP 1172 L L+ + +L F AG ETT+ +L W V L YPE Q++++ E+ +++G P Sbjct: 286 PGLELTDDHLLMTVGDIFGAGVETTTTVLKWAVLYLLHYPEVQKKIQEEMDQKIGLARHP 345 Query: 1173 SGDNLGKLKEMTMVLHETLRLYGPA-LFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRD 1349 + L + + E LR+ + L + + D +G +IPK +VI +H D Sbjct: 346 HLSDRPLLPYLEATISEGLRIRPVSPLLIPHVSLADTSIGEYSIPKGARVVINLWSVHHD 405 Query: 1350 KKVWGEDADQFNPMRFANGVARAAKVPH-ALLAFSIGPRACIGQNFAMLEAKSVMATVLQ 1526 +K W + ++FNP RF + + P + L F G R C+G+ A +E +A VLQ Sbjct: 406 EKEW-DKPEEFNPGRFLDEQGQHIHSPSPSYLPFGAGIRVCLGEVLAKMELFLFLAWVLQ 464 Query: 1527 KFS 1535 +F+ Sbjct: 465 RFT 467
>Q43078:C97B1_PEA Cytochrome P450 97B1 - Pisum sativum (Garden pea)| Length = 552 Score = 102 bits (255), Expect = 4e-21 Identities = 105/435 (24%), Positives = 179/435 (41%), Gaps = 46/435 (10%) Frame = +3 Query: 333 WRAQYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHFPKNDAHPNXXXXXXXXXXXXXX 512 W ++G + FG K + V D + R IL + + K Sbjct: 110 WFLEHGSVYKLAFGPKAFVVVSDPIVARHILRENAFSYDKGVLADILEPIMGKGLIPADL 169 Query: 513 XDWVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTF---GVFEEQASKNTNKEIQVEFDKSV 683 W + RRVI P F ++AM + SC++ T E ++ K ++++ + Sbjct: 170 ETWKQRRRVIAPGFHTSYLEAMVQLFTSCSERTVLKVNELLEGEGRDGQKSVELDLEAEF 229 Query: 684 QELTADIISHTAFGSSYKLGMEAFYAQKELQAIAISSLLNVQIPGFSYLPT-KRNRRKWM 860 L +II F +Y G + + + +L + Y+P K +W+ Sbjct: 230 SNLALEIIGLGVF--NYDFG--SVTNESPVIKAVYGTLFEAEHRSTFYIPYWKFPLARWI 285 Query: 861 L--EKKLRSTLMRIINSRLA-----SQGSGYGNDLLGLMLEGCTETEQGG------KQEQ 1001 + ++K + L ++IN+ L ++ S D+ L + + Sbjct: 286 VPRQRKFQDDL-KVINTCLDGLIRNAKESRQETDVEKLQQRDYSNLKDASLLRFLVDMRG 344 Query: 1002 LSLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGKGDPSGD 1181 + + ++ + T AG+ETT+ +LTW VFLL+ P+ ++ +AEV +G G P+ + Sbjct: 345 VDVDDRQLRDDLMTMLIAGHETTAAVLTWAVFLLAQNPDKMKKAQAEVDLVLGMGKPTFE 404 Query: 1182 NLGKLKEMTMVLHETLRLY-GPALFMQRKTTTDMVVG-------AITIPKEHAIVIGAPF 1337 L KL+ + +++ ETLRLY P L ++R D++ G TIP + I Sbjct: 405 LLKKLEYIRLIVVETLRLYPQPPLLIRRSLKPDVLPGGHKGDKDGYTIPAGTDVFISVYN 464 Query: 1338 MHRDKKVWGEDADQFNPMRF--------ANGVA-------RAAKVPH------ALLAFSI 1454 +HR W D F P RF G A A P+ A L F Sbjct: 465 LHRSPYFWDRPND-FEPERFLVQNNNEEVEGWAGFDPSRSPGALYPNEIISDFAFLPFGG 523 Query: 1455 GPRACIGQNFAMLEA 1499 GPR C+G FA++E+ Sbjct: 524 GPRKCVGDQFALMES 538
>Q9V770:C6A17_DROME Probable cytochrome P450 6a17 - Drosophila melanogaster (Fruit fly)| Length = 501 Score = 102 bits (255), Expect = 4e-21 Identities = 114/444 (25%), Positives = 196/444 (44%), Gaps = 21/444 (4%) Frame = +3 Query: 282 HVRDHDYLHRVAPHFLKWRAQYGE---PFL-FWFGAKPRICVFDYELVRQILSSKSGHFP 449 +++D +A F + +Y PF F+F V D EL++++L HF Sbjct: 41 NIKDWPNKRHIAEIFRDYYFKYKNSDYPFAGFFFFFTRTAVVTDMELLKRVLIKDFNHFE 100 Query: 450 KNDAHPNXXXXXXXXXXXXXXXDWVRH-RRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFE 626 N RH R + P F K+K M +V + VF Sbjct: 101 NRGVFYNEIDDPLSATLFSIEGQKWRHLRHKLTPTFTSGKMKNMFPIVVKVGEEMDKVFR 160 Query: 627 EQASKNTNKEIQVEFDKSVQELTADIISHTAFGSSYKLGMEAFYAQK-ELQAIA------ 785 + + + + ++V V TAD+I + AFG L + Y K E +I Sbjct: 161 SKTAADRGQVLEVV--DLVARYTADVIGNCAFG----LNCNSLYDPKAEFVSIGKRAITE 214 Query: 786 --ISSLLNVQIPGFSYLPTKRNRRKWMLEKK---LRSTLMRIINSRLASQGSGYGNDLLG 950 ++L++ + GF L ++R R K +++ + I+ RL ++ ND + Sbjct: 215 HRYGNMLDIFLFGFPKL-SRRLRLKLNIQEAEDFYTKIVRETIDYRLRTKEKR--NDFMD 271 Query: 951 LMLEGCTETEQGGKQEQLSLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQER 1130 ++E + EQ G E L+ E+L + FF AG+ET+S + + ++ L+ + Q++ Sbjct: 272 SLIE-MYKNEQSGNSED-GLTFNELLAQAFIFFVAGFETSSTTMGFALYELARNQDVQDK 329 Query: 1131 LRAEVLREVGKGDP--SGDNLGKLKEMTMVLHETLRLYGPALFMQRKTTTDMVVG--AIT 1298 LR E+ GK + + + + ++K + V+ ETLR Y + R T TD Sbjct: 330 LREEIGNVFGKHNKEFTYEGIKEMKYLEQVVMETLRKYPVLAHLTRMTDTDFSPEDPKYF 389 Query: 1299 IPKEHAIVIGAPFMHRDKKVWGEDADQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQ 1478 I K +VI A +H D ++ E + F P RF + AA+ L F GPR CIG Sbjct: 390 IAKGTIVVIPALGIHYDPDIYPEP-EIFKPERFTDEEI-AARPSCTWLPFGEGPRNCIGL 447 Query: 1479 NFAMLEAKSVMATVLQKFSFALSP 1550 F M++ +A +++ + F++SP Sbjct: 448 RFGMMQTCVGLAYLIRGYKFSVSP 471
>Q95031:CP6B6_HELAM Cytochrome P450 6B6 - Helicoverpa armigera (Cotton bollworm)| (Heliothis armigera) Length = 504 Score = 101 bits (252), Expect = 9e-21 Identities = 101/363 (27%), Positives = 158/363 (43%), Gaps = 25/363 (6%) Frame = +3 Query: 519 WVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQELTA 698 W R P F K K M M A + F + S K + E +Q T Sbjct: 125 WRALRNRFTPIFTSGKPKNMFYLMHEGADN----FIDHVSAECEKNQEFEVHSLLQTYTM 180 Query: 699 DIISHTAFGSSY--------------KLGMEAFYA-QKELQAIAISSLLNVQIPGFSYLP 833 I+ AFG SY K+ E YA + ++ + S LN+ I P Sbjct: 181 STIAACAFGISYDSIGDKVKALDIVDKIISEPSYAIELDMMYPGLLSKLNLSI-----FP 235 Query: 834 TKRNRRKWMLEKKLRSTLMRIINSRLASQGSGYGNDLLGLMLE-----GCTETEQGGKQE 998 T K +L+ I ++ + SG ND + L+LE T + G Sbjct: 236 TA--------VKNFFKSLVDNIVAQRNGKPSGR-NDFMDLILELRQLGEVTSNKYGSSAS 286 Query: 999 QLSLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEV--LREVGKGDP 1172 L ++ E I + F+ AGYET++ + + ++ L++ P+ Q +L AEV + + G Sbjct: 287 SLEITDEVICAQAFVFYIAGYETSATTMAYMIYQLALSPDIQNKLIAEVDEVLKANDGKV 346 Query: 1173 SGDNLGKLKEMTMVLHETLRLYGPALFMQRKTTTDMVVGA--ITIPKEHAIVIGAPFMHR 1346 + D + ++K M ETLR+Y +QRK T D + + I K+ ++I +H Sbjct: 347 TYDTVKEMKYMNKAFDETLRMYSIVEPLQRKATRDYKIPGTDVVIEKDTIVLISPRGIHY 406 Query: 1347 DKKVWGEDADQFNPMRF-ANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVL 1523 D K + ++ QFNP RF A V + + P A L F +G R CIG F L++ + +L Sbjct: 407 DPKYY-DNPKQFNPDRFDAEEVGK--RHPCAYLPFGLGQRNCIGMRFGRLQSLLCITKIL 463 Query: 1524 QKF 1532 KF Sbjct: 464 SKF 466
>Q27664:CP6B2_HELAM Cytochrome P450 6B2 - Helicoverpa armigera (Cotton bollworm)| (Heliothis armigera) Length = 504 Score = 101 bits (252), Expect = 9e-21 Identities = 101/360 (28%), Positives = 157/360 (43%), Gaps = 15/360 (4%) Frame = +3 Query: 519 WVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQELTA 698 W R P F K+K M M A + F + SK K + E +Q T Sbjct: 125 WRTLRNRFTPIFTSGKLKNMFYLMNEGADN----FIDHVSKECEKHQEFEIHTLLQTYTM 180 Query: 699 DIISHTAFGSSY-----KLGMEAFYAQKELQAIAISSLLNVQIPGFSYLPTKRNRRKWML 863 IS AFG SY KL A K + + + L++ PG LP + Sbjct: 181 STISSCAFGVSYDTISDKLDTLAI-VDKIISEPSYAIELDMMYPGL--LPKLNLSIFPSV 237 Query: 864 EKKLRSTLMRIINSRLASQGSGYGNDLLGLMLE-----GCTETEQGGKQEQLSLSMEEIL 1028 K L+ I ++ + SG ND + L+LE T + G L ++ + Sbjct: 238 VHKFFKNLVNTIVTQRNGKPSGR-NDFMDLILELRQMGEITSNKYGNNMSTLEITESVMC 296 Query: 1029 HECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREV--GKGDPSGDNLGKLKE 1202 + F+ AGYET++ + + + L++ P+ Q +L AE+ + G + D + +K Sbjct: 297 AQAFVFYIAGYETSATTMAYLTYQLALNPDIQNKLIAEIDEAIKANGGKVTYDTVKDMKY 356 Query: 1203 MTMVLHETLRLYGPALFMQRKTTTDMVVGA--ITIPKEHAIVIGAPFMHRDKKVWGEDAD 1376 + V ETLR+Y +QRK D + + I K+ ++I +H D K + ++ Sbjct: 357 LNKVFDETLRMYSIVEPLQRKAIRDYKLPGTDVVIEKDTVVLISPRGIHYDPKYY-DNPK 415 Query: 1377 QFNPMR-FANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSPS 1553 QFNP R FA V + + P A L F +G R CIG F L++ + +L K F L PS Sbjct: 416 QFNPERFFAEEVGK--RHPCAYLPFGLGQRNCIGMRFGRLQSLLCITKLLSK--FRLEPS 471
>Q9V774:C6A21_DROME Probable cytochrome P450 6a21 - Drosophila melanogaster (Fruit fly)| Length = 504 Score = 101 bits (252), Expect = 9e-21 Identities = 109/426 (25%), Positives = 185/426 (43%), Gaps = 22/426 (5%) Frame = +3 Query: 333 WRAQYGE-----PF--LFWFGAKPRICVFDYELVRQILSSKSGHFP-KNDAHPNXXXXXX 488 W + Y + PF +WF +P + V + L +QIL + F + H Sbjct: 59 WTSYYNKFRGSGPFAGFYWF-RRPAVFVLETSLAKQILIKEFNKFTDRGFFHNPEDDPLS 117 Query: 489 XXXXXXXXXDWVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVE 668 W R + F K+K M T+V A VF +N K VE Sbjct: 118 GQLFLLDGQKWRTMRNKLSSTFTSGKMKYMFPTVVKVANEFTDVF----GQNVAKSPVVE 173 Query: 669 FDKSVQELTADIISHTAFG---SSYKLGMEAFYAQKELQAIAISSLLNVQIPGFSYLPTK 839 + + T D+I AFG SS K +A + + +++ L V I + P Sbjct: 174 VRELLARFTTDVIGTCAFGIECSSLK-DPDAEFREMGRRSLTEQRLGPVGIGFVNSFPNL 232 Query: 840 RNRRKW-MLEKKLRSTLMRIINSRLA--SQGSGYGNDLLGLMLEGCTE---TEQGGKQEQ 1001 R M + + MRI+ +A Q + ND + +++ + Q G E Sbjct: 233 ARRLHMKMTAEPIERFFMRIVRETVAFREQNNIRRNDFMDQLIDLKNKPLMVSQSG--ES 290 Query: 1002 LSLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGK--GDPS 1175 ++L++EEI + FF AG+ET+S + + ++ L+ + Q R+R E + K G+ + Sbjct: 291 VNLTIEEIAAQAFVFFAAGFETSSTTMGFALYELAQNQDIQNRVRKECQEVIEKCNGELN 350 Query: 1176 GDNLGKLKEMTMVLHETLRLYGPALFMQRKTTTDMVVGA---ITIPKEHAIVIGAPFMHR 1346 +++ L + V+ ETLRLY + R+ D V I K ++I MHR Sbjct: 351 YESMKDLVYLDQVVSETLRLYTVLPVLNRECLEDYEVPGHPKYVIKKGMPVLIPCGAMHR 410 Query: 1347 DKKVWGEDADQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQ 1526 D+K++ + + FNP F+ + + L F GPR CIG F ++A+ +A +++ Sbjct: 411 DEKLYA-NPNTFNPDNFSPERVK-ERDSVEWLPFGDGPRNCIGMRFGQMQARIGLALLIK 468 Query: 1527 KFSFAL 1544 F F++ Sbjct: 469 DFKFSV 474
>Q92113:CP17A_SQUAC Cytochrome P450 17A1 - Squalus acanthias (Spiny dogfish)| Length = 509 Score = 101 bits (251), Expect = 1e-20 Identities = 95/429 (22%), Positives = 173/429 (40%), Gaps = 16/429 (3%) Frame = +3 Query: 318 PHFL--KWRAQYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHF---PKNDAHPNXXXX 482 PH L K + YG F G + + +++ +++L K F P Sbjct: 54 PHLLFQKLQKTYGNLFSLMMGPHYAVVINNHQHAKEVLLKKGKIFAGRPSMVTTDLLSRG 113 Query: 483 XXXXXXXXXXXDWVRHRRVIDPAFAM--DKIKAMTKTMVSCAQSTFGVFEEQASKNTNKE 656 W HR+++ A + D + K + A S FE N + Sbjct: 114 GKDIAFGKYGPAWKFHRKLVLSALHLFGDGSAGIEKMICQEATSMCSTFERL--NNAAHD 171 Query: 657 IQVEFDKSVQELTADIISHTAFGSSYKLGMEAF-----YAQKELQAIAISSLLNVQIPGF 821 + + ++V ++I F S+Y+ F Y+Q + +A SL+++ P Sbjct: 172 MMPDVTRAV----TNVICLLCFNSTYEKEDPEFQTMRKYSQGIVNTVAKDSLIDI-FPWL 226 Query: 822 SYLPTKRNRRKWMLEKKLRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGGKQ-E 998 + P + S L + A+ S NDL ++L+ E Sbjct: 227 QFFPNENLHTLKQCIATRDSILQKKFEDHKANYSSDSANDLFNILLKAKMNAENNNSSVH 286 Query: 999 QLSLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVG-KGDPS 1175 + L+ + ++ F AG ET+S W + L +PE Q++++ E+ +G + P Sbjct: 287 EAGLTDDHMVMTVADIFGAGVETSSTAFAWMIIYLIHHPEVQKKIQEEIDSNIGFERTPK 346 Query: 1176 GDNLGKLKEMTMVLHETLRLYGPA-LFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDK 1352 + G + + +HE LR+ + L + D +G TIPK ++I +H D+ Sbjct: 347 MSDKGNMNFLNATIHEILRIQPVSPLLIPHVALADSSIGDYTIPKGTRVIINLWAIHHDE 406 Query: 1353 KVWGEDADQFNPMRFANGVAR-AAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQK 1529 K W ++ D F+P RF + + + L F G R C+G+ A +E + +LQ+ Sbjct: 407 KEW-KNPDAFDPGRFLDEDGKYVCSSSESYLPFGAGTRVCLGEMLARMELFLFTSWILQR 465 Query: 1530 FSFALSPSY 1556 F+ + P Y Sbjct: 466 FTVQVPPGY 474
>P24557:THAS_HUMAN Thromboxane-A synthase - Homo sapiens (Human)| Length = 533 Score = 100 bits (250), Expect = 2e-20 Identities = 101/447 (22%), Positives = 176/447 (39%), Gaps = 39/447 (8%) Frame = +3 Query: 327 LKWRAQYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHFPKNDAHPNXXXXXXXXXXXX 506 ++ R YG ++ G + I + + ++++Q+L +F A Sbjct: 68 MELRKLYGPLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKSVADSVLFL 127 Query: 507 XXXDWVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQ 686 W R + AF+ +K+ M + + A +IQ + Sbjct: 128 RDKRWEEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQ----RCYC 183 Query: 687 ELTADIISHTAFGS---SYKLGMEAF---------YAQKELQAIAISSLLNVQIPGFSYL 830 T D+++ FG+ S++ + F + + + S ++ +P L Sbjct: 184 NYTTDVVASVPFGTPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPLARIL 243 Query: 831 PTKRN-----------------RRKWMLEKKLRSTLMRIINSRLASQGSGYGN-DLLGLM 956 P K R + E++ R L ++++R ++ G + D++ + Sbjct: 244 PNKNRDELNGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIVRDV 303 Query: 957 LEGCTETEQGGKQEQLS-----LSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEW 1121 +Q Q S L+++EI+ + F AGYE + L++ +LL+ P+ Sbjct: 304 FSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDC 363 Query: 1122 QERLRAEVLREVGKGDPSGDNLGKLKE----MTMVLHETLRLYGPALFMQRKTTTDMVVG 1289 QE+L EV +V K L+E + MV+ ETLR+Y PA R+ D V Sbjct: 364 QEKLLREV--DVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVL 421 Query: 1290 AITIPKEHAIVIGAPFMHRDKKVWGEDADQFNPMRFANGVARAAKVPHALLAFSIGPRAC 1469 IP + + +H D + W + FNP RF AR P L F GPR+C Sbjct: 422 GQRIPAGAVLEMAVGALHHDPEHW-PSPETFNPERFT-AEARQQHRPFTYLPFGAGPRSC 479 Query: 1470 IGQNFAMLEAKSVMATVLQKFSFALSP 1550 +G +LE K + VL KF F P Sbjct: 480 LGVRLGLLEVKLTLLHVLHKFRFQACP 506
>P79152:CP3AJ_CAPAE Cytochrome P450 3A19 - Capra aegagrus (Wild goat)| Length = 218 Score = 100 bits (250), Expect = 2e-20 Identities = 54/174 (31%), Positives = 98/174 (56%), Gaps = 1/174 (0%) Frame = +3 Query: 1020 EILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREV-GKGDPSGDNLGKL 1196 E++ + F F GYETTS L++ ++ L+ +P+ Q++L+ E+ K P+ D L ++ Sbjct: 5 ELVAQTTIFIFGGYETTSTSLSFIIYELATHPDVQQKLQEEIDATFPNKAPPTYDALVQM 64 Query: 1197 KEMTMVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDAD 1376 + + MV++ETLR++ A ++R D+ + ++IPK +++ +H + + W E + Sbjct: 65 EYLDMVVNETLRMFPIAGRLERLCKKDVEIHGVSIPKGTTVMVPLFVLHNNPEFWPEP-E 123 Query: 1377 QFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSF 1538 +F P RF+ P+ L F GPR C+G FA++ K + +LQ FSF Sbjct: 124 EFRPERFSKKNKDGIN-PYVYLPFGTGPRNCVGMRFALMNIKLALVRILQNFSF 176
>Q2KIG5:THAS_BOVIN Thromboxane-A synthase - Bos taurus (Bovine)| Length = 533 Score = 100 bits (249), Expect = 2e-20 Identities = 103/448 (22%), Positives = 175/448 (39%), Gaps = 40/448 (8%) Frame = +3 Query: 327 LKWRAQYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHFPKNDAHPNXXXXXXXXXXXX 506 ++ R QYG ++ G I + + +++ Q+L K +F A Sbjct: 68 MELRKQYGPLSGYYLGRLMFIVISEPDMIEQVLVEKFSNFTNRMATGLEPKPVADSVLFL 127 Query: 507 XXXDWVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQ 686 W R V+ AF+ +K+ MT + E A +IQ ++ Sbjct: 128 RDKRWEEVRSVLTVAFSPEKLSEMTPLISRACDVLLAHLERHAQSGEAFDIQ----RTYC 183 Query: 687 ELTADIISHTAFGSSYKLGMEA-----------FYAQK--ELQAIAISSLLNVQIPGFSY 827 T D+++ AFG+ EA F+A + + + S ++ +P Sbjct: 184 CYTTDVVASVAFGTEVN-SQEAPEHPFVEHCRRFFASSIPKPLLVLLLSFPSIMVPLARI 242 Query: 828 LPTKRN-----------------RRKWMLEKKLRSTLMRIINSRLASQGSGYGNDLLGLM 956 LP K R + E++ R L + + R ++ G + Sbjct: 243 LPNKNRDELNGFFNKLIRNVIALRDQQAAEERRRDFLQMVQDVRHSAATVGVEKFDIVRQ 302 Query: 957 LEGCTETEQGGKQEQLS------LSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPE 1118 + T+ + LS++E++ + F AGYE + L++ +LL+ PE Sbjct: 303 VFSATKCPANPPRRHSPRPLSKPLSVDEVVGQAFIFLIAGYEIVTNTLSFATYLLATNPE 362 Query: 1119 WQERLRAEVLREVGKGDPSGDNLGKLKE----MTMVLHETLRLYGPALFMQRKTTTDMVV 1286 QE+L EV + + L+E + MV+ ETLR+Y PA R D V Sbjct: 363 CQEKLLEEV--DCFSKEHLAPEYCSLQEGLPYLDMVIKETLRMYPPAFRFTRVAAQDCEV 420 Query: 1287 GAITIPKEHAIVIGAPFMHRDKKVWGEDADQFNPMRFANGVARAAKVPHALLAFSIGPRA 1466 IP + +H D + W + + FNP RF A+ + P+ L F GPR+ Sbjct: 421 LGQRIPAGAVLETAVGALHYDPEHW-PNPENFNPERFT-AEAQQRRRPYTYLPFGAGPRS 478 Query: 1467 CIGQNFAMLEAKSVMATVLQKFSFALSP 1550 C+G +LE K + +L+KF F P Sbjct: 479 CLGVRLGLLELKLTLLHILRKFRFEACP 506
>Q9VG82:CP9F2_DROME Probable cytochrome P450 9f2 - Drosophila melanogaster (Fruit fly)| Length = 516 Score = 100 bits (249), Expect = 2e-20 Identities = 95/412 (23%), Positives = 184/412 (44%), Gaps = 24/412 (5%) Frame = +3 Query: 378 KPRICVFDYELVRQILSSKSGHF---------PKNDAHPNXXXXXXXXXXXXXXXDWVRH 530 +P + V D +L++QI HF +D + W Sbjct: 78 QPLLMVRDPDLIKQITIKDFDHFINHRNVFATSSDDDPHDMSNLFGSSLFSMRDARWKDM 137 Query: 531 RRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQELTADIIS 710 R + PAF K++ M + M A+ ++ S+ E+ ++ T D+I+ Sbjct: 138 RSTLSPAFTGSKMRQMFQLMNQVAKEAVDCLKQDDSRVQENELDMK--DYCTRFTNDVIA 195 Query: 711 HTAFG---SSYKLGMEAFYAQ-KELQAIAISSLLNVQIPGFSYLPTKRNRRKWMLEKKLR 878 TAFG +S+K FY K+L + + F+ + + + ++K Sbjct: 196 STAFGLQVNSFKDRENTFYQMGKKLTTFTFLQSMKFML-FFALKGLNKILKVELFDRKST 254 Query: 879 STLMRIINSRLA--SQGSGYGNDLLGLMLE--GCTETEQGGKQEQLSLSMEEILHECKTF 1046 +R++ + + + D++ +++E G +TE+ S +I+ +C F Sbjct: 255 QYFVRLVLDAMKYRQEHNIVRPDMINMLMEARGIIQTEKTKASAVREWSDRDIVAQCFVF 314 Query: 1047 FFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVL---REVGKGDPSGDNLGKLKEMTMVL 1217 FFAG+ET+++L+ +T L + Q+RL EV +++ + + + + +K + V+ Sbjct: 315 FFAGFETSAVLMCFTAHELMENQDVQQRLYEEVQQVDQDLEGKELTYEAIMGMKYLDQVV 374 Query: 1218 HETLRLYGPALFMQRKTTTDMVVGA----ITIPKEHAIVIGAPFMHRDKKVWGEDADQFN 1385 +E LR + A+ + R+ D+ + + K I + HRD K + E+ +F+ Sbjct: 375 NEVLRKWPAAIAVDRECNKDITFDVDGQKVEVKKGDVIWLPTCGFHRDPKYF-ENPMKFD 433 Query: 1386 PMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFA 1541 P RF++ + + P F +G R CIG FA+LEAK+V+ +L+ + FA Sbjct: 434 PERFSDENKESIQ-PFTYFPFGLGQRNCIGSRFALLEAKAVIYYLLKDYRFA 484
>Q8HYN0:CP17A_PAPCY Cytochrome P450 17A1 - Papio cynocephalus (Yellow baboon)| Length = 508 Score = 100 bits (249), Expect = 2e-20 Identities = 100/427 (23%), Positives = 173/427 (40%), Gaps = 14/427 (3%) Frame = +3 Query: 294 HDYLHRVAPHFLKWRAQYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHF---PKNDAH 464 H ++H +F K + +YG + G K + V ++L +++L K F P+ Sbjct: 46 HGHMHN---NFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQVTTL 102 Query: 465 PNXXXXXXXXXXXXXXXDWVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKN 644 W HRR+ FA+ K + C + + + + Sbjct: 103 DILSNNRKGIAFADYGAHWQLHRRLAMATFALFKDGDQKLEKIICQE--ISTLCDMLATH 160 Query: 645 TNKEIQVEFDKSVQELTADIISHTAFGSSYKLGMEAF-----YAQKELQAIAISSLLNVQ 809 + I + F V ++IS F SYK G Y + + ++ SL+++ Sbjct: 161 NGQTIDISFPVFVA--ITNVISLICFNISYKNGDPELKIVHNYNEGIIDSLGKESLVDL- 217 Query: 810 IPGFSYLPTKRNRRKWMLEKKLRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGG 989 P P K + K L +I + S ++L ++++ ++ G Sbjct: 218 FPWLKVFPNKTLEKLKRHVKTRNDLLTKIFENYKEKFRSDSITNMLDVLMQAKMNSDNGN 277 Query: 990 K---QEQLSLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVG 1160 Q+ LS IL F AG ETT+ ++ W V L P+ +++L E+ + VG Sbjct: 278 AGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWIVAFLLHNPQVKKKLYEEIDQNVG 337 Query: 1161 -KGDPSGDNLGKLKEMTMVLHETLRLYGPA-LFMQRKTTTDMVVGAITIPKEHAIVIGAP 1334 P+ + +L + + E LR+ A + + K D +G + K ++I Sbjct: 338 FSRTPTISDRNRLLLLEATIREVLRIRPVAPMLIPHKANVDSSIGEFAVDKGTHVIINLW 397 Query: 1335 FMHRDKKVWGEDADQFNPMRFANGVARAAKVPH-ALLAFSIGPRACIGQNFAMLEAKSVM 1511 +H ++K W DQF P RF N P + L F GPR+CIG+ A E +M Sbjct: 398 ALHHNEKEW-HQPDQFMPERFLNPAGTQLISPSLSYLPFGAGPRSCIGEILARQELFLIM 456 Query: 1512 ATVLQKF 1532 A +LQ+F Sbjct: 457 AWLLQRF 463
>Q8HYM9:CP17A_MACMU Cytochrome P450 17A1 - Macaca mulatta (Rhesus macaque)| Length = 508 Score = 100 bits (249), Expect = 2e-20 Identities = 100/427 (23%), Positives = 173/427 (40%), Gaps = 14/427 (3%) Frame = +3 Query: 294 HDYLHRVAPHFLKWRAQYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHF---PKNDAH 464 H ++H +F K + +YG + G K + V ++L +++L K F P+ Sbjct: 46 HGHMHN---NFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQVTTL 102 Query: 465 PNXXXXXXXXXXXXXXXDWVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKN 644 W HRR+ FA+ K + C + + + + Sbjct: 103 DILSNNRKGIAFADYGAHWQLHRRLAMATFALFKDGDQKLEKIICQE--ISTLCDMLATH 160 Query: 645 TNKEIQVEFDKSVQELTADIISHTAFGSSYKLGMEAF-----YAQKELQAIAISSLLNVQ 809 + I + F V ++IS F SYK G Y + + ++ SL+++ Sbjct: 161 NGQTIDISFPVFVA--ITNVISLICFNISYKNGDPELKIVHNYNEGIIDSLGKESLVDL- 217 Query: 810 IPGFSYLPTKRNRRKWMLEKKLRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGG 989 P P K + K L +I + S ++L ++++ ++ G Sbjct: 218 FPWLKVFPNKTLEKLKRHVKTRNDLLTKIFENYKEKFHSDSITNMLDVLMQAKMNSDNGN 277 Query: 990 K---QEQLSLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVG 1160 Q+ LS IL F AG ETT+ ++ W V L P+ +++L E+ + VG Sbjct: 278 AGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWIVAFLLHNPQVKKKLYEEIDQNVG 337 Query: 1161 -KGDPSGDNLGKLKEMTMVLHETLRLYGPA-LFMQRKTTTDMVVGAITIPKEHAIVIGAP 1334 P+ + +L + + E LR+ A + + K D +G + K ++I Sbjct: 338 FSRTPTISDRNRLLLLEATIREVLRIRPVAPMLIPHKANVDSSIGEFAVDKGTHVIINLW 397 Query: 1335 FMHRDKKVWGEDADQFNPMRFANGVARAAKVPH-ALLAFSIGPRACIGQNFAMLEAKSVM 1511 +H ++K W DQF P RF N P + L F GPR+CIG+ A E +M Sbjct: 398 ALHHNEKEW-HQPDQFMPERFLNPAGTQLISPSLSYLPFGAGPRSCIGEILARQELFLIM 456 Query: 1512 ATVLQKF 1532 A +LQ+F Sbjct: 457 AWLLQRF 463
>Q2XVA1:CP17A_MACFA Cytochrome P450 17A1 - Macaca fascicularis (Crab eating macaque)| (Cynomolgus monkey) Length = 508 Score = 100 bits (249), Expect = 2e-20 Identities = 100/427 (23%), Positives = 173/427 (40%), Gaps = 14/427 (3%) Frame = +3 Query: 294 HDYLHRVAPHFLKWRAQYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHF---PKNDAH 464 H ++H +F K + +YG + G K + V ++L +++L K F P+ Sbjct: 46 HGHMHN---NFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQVTTL 102 Query: 465 PNXXXXXXXXXXXXXXXDWVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKN 644 W HRR+ FA+ K + C + + + + Sbjct: 103 DILSNNRKGIAFADYGAHWQLHRRLAMATFALFKDGDQKLEKIICQE--ISTLCDMLATH 160 Query: 645 TNKEIQVEFDKSVQELTADIISHTAFGSSYKLGMEAF-----YAQKELQAIAISSLLNVQ 809 + I + F V ++IS F SYK G Y + + ++ SL+++ Sbjct: 161 NGQTIDISFPVFVA--ITNVISLICFNISYKNGDPELKIVHNYNEGIIDSLGKESLVDL- 217 Query: 810 IPGFSYLPTKRNRRKWMLEKKLRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGG 989 P P K + K L +I + S ++L ++++ ++ G Sbjct: 218 FPWLKVFPNKTLEKLKRHVKTRNDLLTKIFENYKEKFHSDSITNMLDVLMQAKMNSDNGN 277 Query: 990 K---QEQLSLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVG 1160 Q+ LS IL F AG ETT+ ++ W V L P+ +++L E+ + VG Sbjct: 278 AGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWIVAFLLHNPQVKKKLYEEIDQNVG 337 Query: 1161 -KGDPSGDNLGKLKEMTMVLHETLRLYGPA-LFMQRKTTTDMVVGAITIPKEHAIVIGAP 1334 P+ + +L + + E LR+ A + + K D +G + K ++I Sbjct: 338 FSRTPTISDRNRLLLLEATIREVLRIRPVAPMLIPHKANVDSSIGEFAVDKGTHVIINLW 397 Query: 1335 FMHRDKKVWGEDADQFNPMRFANGVARAAKVPH-ALLAFSIGPRACIGQNFAMLEAKSVM 1511 +H ++K W DQF P RF N P + L F GPR+CIG+ A E +M Sbjct: 398 ALHHNEKEW-HQPDQFMPERFLNPAGTQLISPSLSYLPFGAGPRSCIGEILARQELFLIM 456 Query: 1512 ATVLQKF 1532 A +LQ+F Sbjct: 457 AWLLQRF 463
>O61387:CP6B7_HELAM Cytochrome P450 6B7 - Helicoverpa armigera (Cotton bollworm)| (Heliothis armigera) Length = 504 Score = 100 bits (248), Expect = 3e-20 Identities = 103/388 (26%), Positives = 167/388 (43%), Gaps = 24/388 (6%) Frame = +3 Query: 519 WVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQELTA 698 W R P F K+K M M A + F + SK K+ + E +Q T Sbjct: 125 WRALRNRFTPIFTSGKLKNMFYLMHEGADN----FIDHVSKECEKKQEFEVHSLLQTYTM 180 Query: 699 DIISHTAFGSSYKLGMEAFYAQKELQAIAISSLLNVQIP----------GFSYLPTKRNR 848 IS AFG SY + + + I +++ S +PT Sbjct: 181 STISSCAFGVSYNSISDKVQTLEIVDKIISEPSYAIELDYMYPKLLAKLNLSIIPTP--- 237 Query: 849 RKWMLEKKLRSTLMRIINSRLASQGSGYG-NDLLGLMLE-----GCTETEQGGKQEQLSL 1010 ++ +S + II+ R G G ND + L+LE T + L + Sbjct: 238 ----VQHFFKSLVDNIISQR---NGKPAGRNDFMDLILELRQMGEVTSNKYLDGVTSLEI 290 Query: 1011 SMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREV--GKGDPSGDN 1184 + E I + F+ AGYET++ +++ ++ LS+ + Q +L AEV + G + D Sbjct: 291 TDEVICAQAFVFYVAGYETSATTMSYLIYQLSLNQDVQNKLIAEVDEAIKASDGKVTYDT 350 Query: 1185 LGKLKEMTMVLHETLRLYGPALFMQRKTTTDMVVGA--ITIPKEHAIVIGAPFMHRDKKV 1358 + ++K + V ETLR+Y +QRK T D + + I K+ ++I +H D K Sbjct: 351 VKEMKYLNKVFDETLRMYSIVEPLQRKATRDYQIPGTDVVIEKDTMVLISPRGIHYDPKY 410 Query: 1359 WGEDADQFNPMRF-ANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFS 1535 + ++ QFNP RF A V + + P A L F +G R CIG F L++ + +L KF Sbjct: 411 Y-DNPKQFNPDRFDAEEVGK--RHPCAYLPFGLGQRNCIGMRFGRLQSLLCITKILSKFR 467 Query: 1536 FALSPS---YVHAPADFLTLRPKFGLPV 1610 S + + +T+ PK G+ V Sbjct: 468 IEPSKNTDRNLQVEPRRVTIGPKGGIRV 495
>O18596:C4D10_DROMT Cytochrome P450 4d10 - Drosophila mettleri (Fruit fly)| Length = 513 Score = 99.4 bits (246), Expect = 5e-20 Identities = 68/205 (33%), Positives = 104/205 (50%), Gaps = 4/205 (1%) Frame = +3 Query: 1020 EILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGKGDPSG---DNLG 1190 +I E TF F G++TTS +T+ + +++YPE Q + E++ +GK + D L Sbjct: 306 DIREEVDTFMFEGHDTTSSGITFFFYNIALYPECQRKCVEEIVSVLGKDTETPVTYDLLN 365 Query: 1191 KLKEMTMVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGED 1370 L M + + ETLR+Y + RK + + IP I I F+ R + + E Sbjct: 366 NLNYMDLCIKETLRMYPSVPLLGRKVLQECEINGKIIPAGTNIGISPLFLGRSEDISSEP 425 Query: 1371 ADQFNPMRFANGVARAAKV-PHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALS 1547 + F P RF + V A K+ PHA + FS GPR CIGQ FAMLE K++ A VL+ + Sbjct: 426 -NTFKPERF-DVVTSAEKLNPHAYIPFSAGPRNCIGQKFAMLEIKAIAANVLRHYEIEFV 483 Query: 1548 PSYVHAPADFLTLRPKFGLPVVMKL 1622 + +P L + P++ KL Sbjct: 484 GNAEESPVLIAELILRTKDPLMFKL 508
>P51590:CP2J3_RAT Cytochrome P450 2J3 - Rattus norvegicus (Rat)| Length = 502 Score = 98.6 bits (244), Expect = 8e-20 Identities = 80/299 (26%), Positives = 133/299 (44%), Gaps = 12/299 (4%) Frame = +3 Query: 678 SVQELTADIISHTAFGSSYKLGMEAFYAQKEL--QAIAISSLLNVQIPGF-----SYLPT 836 ++ + ++II FG ++ F L +A+ + S + Q+ YLP Sbjct: 183 NINKAVSNIICSVTFGERFEYHDSQFQEMLRLLDEAMCLESSMMCQLYNIFPRILQYLPG 242 Query: 837 KRNR--RKWMLEKKLRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGGKQEQLSL 1010 W +KL+ + II + D + L+ E + + S Sbjct: 243 SHQTLFSNW---RKLKLFISDIIKNHRRDWDPDEPRDFIDAFLK---EMAKYPDKTTTSF 296 Query: 1011 SMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGKG-DPSGDNL 1187 + E ++ FFAG ETTS L W + +++YPE QE+++AE+ R +G+G P+ + Sbjct: 297 NEENLICSTLDLFFAGTETTSTTLRWALLCMALYPEVQEKMQAEIDRVIGQGRQPNLADR 356 Query: 1188 GKLKEMTMVLHETLRLYGPALF-MQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWG 1364 + V+HE R+ F + R+ D + +PK I+ +HRD K W Sbjct: 357 DSMPYTNAVIHEVQRIGNIIPFNVPREVAVDTYLAGFNLPKGTMILTNLTALHRDPKEWA 416 Query: 1365 EDADQFNPMRF-ANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSF 1538 D FNP F NG K + L FS+G RAC+G+ A E + +++QKF+F Sbjct: 417 -TPDTFNPEHFLENG---QFKKRESFLPFSMGKRACLGEQLARSELFIFITSLIQKFTF 471
>Q91Z85:CP17A_PERLE Cytochrome P450 17A1 - Peromyscus leucopus (White-footed mouse)| Length = 509 Score = 98.6 bits (244), Expect = 8e-20 Identities = 102/431 (23%), Positives = 180/431 (41%), Gaps = 18/431 (4%) Frame = +3 Query: 294 HDYLHRVAPHFLKWRAQYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHF---PKNDAH 464 H ++H +F K + +YG + G P + + Y+L R++L K F P+ Sbjct: 46 HGHMH---VNFFKLQEKYGPIYSLRLGTIPTVIIGQYQLAREVLIKKGKEFSGRPQMVTL 102 Query: 465 PNXXXXXXXXXXXXXXXDWVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKN 644 W HR++ +FA+ + + C +++ Sbjct: 103 GLLSNQGKGIAFADSDDAWQLHRKLALSSFALFRDGDQRLETIICQEAS----SLCDLLL 158 Query: 645 TNKEIQVEFDKSVQELTADIISHTAFGSSYK-----LGMEAFYAQKELQAIAISSLLNVQ 809 T+ E V+ + + +II F +SY+ L + + L + +L+++ Sbjct: 159 THNEESVDLSQPIFMSVTNIICAICFSTSYENRDPILTTIQTFTEGILNCLDNENLVDI- 217 Query: 810 IPGFSYLPTKRNRRKWMLEKKLRSTLMR--IINSRLASQGSGYGND----LLGLMLEGCT 971 P + P K LEK R +R ++ L + ND L ++++ Sbjct: 218 FPWLTIFPNKT------LEKIKRHVKVRDEVLIDMLEKCKEKFNNDSISNLTDILIQAKM 271 Query: 972 ETEQGGKQE-QLSLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVL 1148 + + Q S S IL FF AG ETT+ +L W V L PE +++++ E+ Sbjct: 272 NADNNNTTDHQGSFSDSHILSTVGDFFGAGIETTTSVLCWIVAFLLHNPEVKKKIQKEID 331 Query: 1149 REVG-KGDPSGDNLGKLKEMTMVLHETLRLYGPA-LFMQRKTTTDMVVGAITIPKEHAIV 1322 + +G P+ ++ L + + E LR+ A + + K D +G TIPK+ +V Sbjct: 332 QNIGFSRTPTFNDRNHLLMLEATIREVLRIRPVAPMLIPHKANIDSSIGEFTIPKDTHVV 391 Query: 1323 IGAPFMHRDKKVWGEDADQFNPMRFANGVARAAKVPH-ALLAFSIGPRACIGQNFAMLEA 1499 I +H ++K W + D+F P RF + P + L F GPRACIG+ A Sbjct: 392 INLWALHHNEKEW-DQPDRFMPERFLDATGSHLITPSLSYLPFGAGPRACIGEVLARQVL 450 Query: 1500 KSVMATVLQKF 1532 +A +LQ+F Sbjct: 451 FLYVACLLQRF 461
>Q9GMC8:CP17A_FELCA Cytochrome P450 17A1 - Felis silvestris catus (Cat)| Length = 508 Score = 98.6 bits (244), Expect = 8e-20 Identities = 98/422 (23%), Positives = 174/422 (41%), Gaps = 17/422 (4%) Frame = +3 Query: 318 PH--FLKWRAQYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHFPKNDAHPNXXXXXXX 491 PH F K + +YG + F G K + V D++L +++L K F H Sbjct: 49 PHKNFFKLQKKYGPIYSFRLGTKTTVMVGDHQLAKEVLVKKGKEF-SGRPHVVTLDILSD 107 Query: 492 XXXXXXXXD----WVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEI 659 D W HR++ FA+ K + C + + + ++ Sbjct: 108 NQKGIAFADHGASWQMHRKLALATFALFKDGDQRLEKIICREISLLCDNLAMQDGQSIDL 167 Query: 660 QVEFDKSVQELTADIISHTAFGSSYKLGMEAF-----YAQKELQAIAISSLLNVQIPGFS 824 + +V +II F SS+K G A Y + L+ + +L+++ P Sbjct: 168 YLPLFLAV----TNIICLICFNSSFKNGDPALKIIQNYNEGILKTLGKDNLVDI-FPVLK 222 Query: 825 YLPTKRNRRKWMLEKKLRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGGK---Q 995 P K + K L I+ + + ++L ++++ ++ G Q Sbjct: 223 IFPNKTLEKMKNYVKNRDELLREILEKHKENFSNDSITNMLDVLIQARMNSDNNGAASDQ 282 Query: 996 EQLSLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVG-KGDP 1172 + LS + IL F AG ETT+ ++ WTV L +P+ ++L+ E+ + +G P Sbjct: 283 DSKLLSDKHILTTIGDIFGAGVETTTSVVRWTVAFLLHHPQLYKKLQEEIDQNIGFSRTP 342 Query: 1173 SGDNLGKLKEMTMVLHETLRLYGPA-LFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRD 1349 + + +L + + E LR+ A + K D +G + K ++I +H + Sbjct: 343 TMSDRNQLILLEATIREVLRIRPVAPTLIPHKAIMDSSIGEFAVDKGTNVIINLWALHHN 402 Query: 1350 KKVWGEDADQFNPMRFANGVARAAKVPH-ALLAFSIGPRACIGQNFAMLEAKSVMATVLQ 1526 +K W DQF P RF + P + L F GPR+C+G++ A E MA +LQ Sbjct: 403 EKEWYR-PDQFMPERFLDPTRSQLISPSLSYLPFGAGPRSCLGESLARQEVFLFMAWLLQ 461 Query: 1527 KF 1532 +F Sbjct: 462 RF 463
>Q6VVW9:CP2R1_MOUSE Cytochrome P450 2R1 - Mus musculus (Mouse)| Length = 501 Score = 98.2 bits (243), Expect = 1e-19 Identities = 104/430 (24%), Positives = 181/430 (42%), Gaps = 10/430 (2%) Frame = +3 Query: 345 YGEPFLFWFGAKPRICVFDYELVRQILSSKSGHFPKNDAHP--NXXXXXXXXXXXXXXXD 518 YGE F G + + Y++V++ L +S F P Sbjct: 73 YGEIFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRG 132 Query: 519 WVRHRRVIDPAFAMDKIKAMTKTMVS-CAQSTFGVFEE-QASKNTNKEIQVEFDKSVQEL 692 W+ HRR+ +F + K+ S + T+ + + + K +++ +V + Sbjct: 133 WIDHRRLAVNSFHY--FGSGQKSFESKILEETWSLIDAIETYKGGPFDLKQLITNAVSNI 190 Query: 693 TADIISHTAF---GSSYKLGMEAFYAQKELQAIAISSLLNVQIPGFSYLPTKRNRRKWML 863 T I+ F + ++ +E F EL A A L N P LP +++R + Sbjct: 191 TNLILFGERFTYEDTDFQHMIELFSENVELAASAPVFLYNA-FPWIGILPFGKHQRLFRN 249 Query: 864 EKKLRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGGKQEQLSLSMEEILHECKT 1043 + L R+I ++ + + L+ E +QG + S E ++ Sbjct: 250 ADVVYDFLSRLIEKAAVNRKPHLPHHFVDAYLD---EMDQGQNDPLSTFSKENLIFSVGE 306 Query: 1044 FFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGKG-DPSGDNLGKLKEMTMVLH 1220 AG ETT+ +L W + +++YP Q ++ E+ VG PS + K+ VLH Sbjct: 307 LIIAGTETTTNVLRWAILFMALYPNIQGQVHKEIDLIVGHNRRPSWEYKCKMPYTEAVLH 366 Query: 1221 ETLRLYG-PALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDADQFNPMRF 1397 E LR L + T+ D VV +IPK ++ +H D+K W +D D F P RF Sbjct: 367 EVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYW-KDPDMFYPERF 425 Query: 1398 ANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSPSYVHAPADF 1577 + K AL+ FS+G R C+G+ A +E ++LQ+F ++H P + Sbjct: 426 LDSNGYFTK-KEALIPFSLGRRHCLGEQLARMEMFLFFTSLLQQF-------HLHFPHEL 477 Query: 1578 L-TLRPKFGL 1604 + L+P+ G+ Sbjct: 478 VPNLKPRLGM 487
>Q9V9L1:CP6W1_DROME Probable cytochrome P450 6w1 - Drosophila melanogaster (Fruit fly)| Length = 514 Score = 97.8 bits (242), Expect = 1e-19 Identities = 92/417 (22%), Positives = 180/417 (43%), Gaps = 21/417 (5%) Frame = +3 Query: 351 EPFL-FWFGAKPRICVFDYELVRQILSSKSGHFPKN--DAHPNXXXXXXXXXXXXXXXDW 521 EPF+ + +P + + D EL++ ++ K +F P+ W Sbjct: 68 EPFVGVYMTHRPALVIRDLELIKTVMIKKFQYFNNRVLQTDPHNDALGYKNLFFARSPGW 127 Query: 522 VRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQELTAD 701 R I P F KIK M MV ++ + +++ +V+ T D Sbjct: 128 RELRTKISPVFTSGKIKQMYPLMVKIGKNL-----QDSAERLGSGTEVQVKDLCSRFTTD 182 Query: 702 IISHTAFGSSYKLGMEA----FYAQKELQAIAISSLLNVQIPGFSYLPTKRNRRKWML-- 863 +I+ AFG +A FY + + ++ +S ++ I +P + + L Sbjct: 183 LIATIAFGVEANALQDAKSEFFYHNRAIFSLTLSRGIDFAI--IFMIPALASLARVKLFS 240 Query: 864 ---EKKLRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGGKQEQLSLSMEEILHE 1034 K +RS++ ++ R + NDL+ ++L E + + ++ ++ + Sbjct: 241 RETTKFIRSSVNYVLKER--ERTGEKRNDLIDILLALKREAAANPGKMSKEVDLDYLVAQ 298 Query: 1035 CKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGKGDP-SGDNLGKLKEMTM 1211 F AG+ET++ +T T++ L+ Q+RLR E++ G D S + + ++ ++ Sbjct: 299 AAVFQTAGFETSASTMTMTLYELAKNEALQDRLRQEIVDFFGDEDHISYERIQEMPYLSQ 358 Query: 1212 VLHETLRLYGPALFMQRKTTTDMVVGAITIPKEH--------AIVIGAPFMHRDKKVWGE 1367 V++ETLR Y +++R+ + T+ H +I + +HRD + W Sbjct: 359 VVNETLRKYPIVGYIERECSQPAEGERFTLEPFHNMELPHGMSIYMSTVAVHRDPQYW-P 417 Query: 1368 DADQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSF 1538 D ++++P RF N R A + F +GPR CIG +L++K + +L+ F Sbjct: 418 DPEKYDPERF-NSSNRDNLNMDAYMPFGVGPRNCIGMRLGLLQSKLGLVHILRNHRF 473
>Q9GLD2:CP17A_PAPHU Cytochrome P450 17A1 - Papio hamadryas ursinus (Chacma baboon)| Length = 508 Score = 97.8 bits (242), Expect = 1e-19 Identities = 99/427 (23%), Positives = 173/427 (40%), Gaps = 14/427 (3%) Frame = +3 Query: 294 HDYLHRVAPHFLKWRAQYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHF---PKNDAH 464 H ++H +F K + +YG + G K + V ++L +++L K F P+ Sbjct: 46 HGHMHN---NFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQVTTL 102 Query: 465 PNXXXXXXXXXXXXXXXDWVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKN 644 W HRR+ FA+ K + C + + + + Sbjct: 103 DILSNNRKGIAFADYGAHWQLHRRLAMATFALFKDGDQKLEKIICQE--ISTLCDMLATH 160 Query: 645 TNKEIQVEFDKSVQELTADIISHTAFGSSYKLGMEAF-----YAQKELQAIAISSLLNVQ 809 + I + F V ++IS F SYK G Y + + ++ SL+++ Sbjct: 161 NGQTIDISFPVFVA--ITNVISLICFNISYKNGDPELKIVHNYNEGIIDSLGKESLVDL- 217 Query: 810 IPGFSYLPTKRNRRKWMLEKKLRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGG 989 P P K + K L +I + S ++L ++++ ++ G Sbjct: 218 FPWLKVFPNKTLEKLKRHVKTRNDLLTKIFENYKEKFRSDSITNMLDVLMQAKMNSDNGN 277 Query: 990 K---QEQLSLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVG 1160 Q+ LS IL F AG ETT+ ++ W V L P+ +++L + + VG Sbjct: 278 AGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWIVAFLLHNPQVKKKLYEGIDQNVG 337 Query: 1161 -KGDPSGDNLGKLKEMTMVLHETLRLYGPA-LFMQRKTTTDMVVGAITIPKEHAIVIGAP 1334 P+ + +L + + E LR+ A + + K D +G + K ++I Sbjct: 338 FSRTPTISDRNRLLLLEATIREVLRIRPVAPMLIPHKANVDSSIGEFAVDKGTHVIINLW 397 Query: 1335 FMHRDKKVWGEDADQFNPMRFANGVARAAKVPH-ALLAFSIGPRACIGQNFAMLEAKSVM 1511 +H ++K W + DQF P RF N P + L F GPR+CIG+ A E +M Sbjct: 398 ALHHNEKEWHQP-DQFMPERFLNPAGTQLISPSLSYLPFGAGPRSCIGEILARQELFLIM 456 Query: 1512 ATVLQKF 1532 A +LQ+F Sbjct: 457 AWLLQRF 463
>P29981:CP4C1_BLADI Cytochrome P450 4C1 - Blaberus discoidalis (Tropical cockroach)| Length = 511 Score = 97.4 bits (241), Expect = 2e-19 Identities = 109/455 (23%), Positives = 189/455 (41%), Gaps = 33/455 (7%) Frame = +3 Query: 345 YGEPFLFWFGAKPRICVFDYELVRQILSSKSGHFPKNDAHPNXXXXXXXXXXXXXXXDWV 524 YG + W G ++ + E V IL H K+ + W Sbjct: 70 YGPLYRIWAGPIAQVGLTRPEHVELILRDTK-HIDKSLVYSFIRPWLGEGLLTGTGAKWH 128 Query: 525 RHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQELTADI 704 HR++I P F + V ++ + ++ SK K+ + + DI Sbjct: 129 SHRKMITPTFHFKILDIFVDVFVEKSEI---LVKKLQSKVGGKDFDIY--PFITHCALDI 183 Query: 705 ISHTAFGSSYKLGMEAFYAQKELQAIAISSLLNVQIPGFSYLPTKRNRRKWMLEK----- 869 I TA G AQ+E ++ + ++ + S L +R+ R W+ K Sbjct: 184 ICETAMGIQMN-------AQEESESEYVKAVYEI-----SELTMQRSVRPWLHPKVIFDL 231 Query: 870 ----KLRSTLMRIIN----------------SRLASQGSGYGNDLLG-----LMLEGCTE 974 K + +RI++ + + S ++LLG L+ E Sbjct: 232 TTMGKRYAECLRILHGFTNKVIQERKSLRQMTGMKPTISNEEDELLGKKKRLAFLDLLLE 291 Query: 975 TEQGGKQEQLSLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLRE 1154 + G + +S +I E TF F G++TTS + W +FLL +PE Q+++ E+ Sbjct: 292 ASENGTK----MSDTDIREEVDTFMFEGHDTTSAGICWALFLLGSHPEIQDKVYEELDHI 347 Query: 1155 VGKGDPSGD--NLGKLKEMTMVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIG 1328 D S +L +K + V+ E+LRL+ F+ R D +G +P + + Sbjct: 348 FQGSDRSTTMRDLADMKYLERVIKESLRLFPSVPFIGRVLKEDTKIGDYLVPAGCMMNLQ 407 Query: 1329 APFMHRDKKVWGEDADQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSV 1508 +HR++ + + + FNP F A + P+A + FS GPR CIGQ FA LE K+V Sbjct: 408 IYHVHRNQDQY-PNPEAFNPDNFLPERV-AKRHPYAYVPFSAGPRNCIGQKFATLEEKTV 465 Query: 1509 MATVLQKFSF-ALSPSYVHAPADFLTLRPKFGLPV 1610 ++++L+ F ++ + L LRP+ G+ V Sbjct: 466 LSSILRNFKVRSIEKREDLTLMNELILRPESGIKV 500
>Q9VB31:C6A18_DROME Probable cytochrome P450 6a18 - Drosophila melanogaster (Fruit fly)| Length = 507 Score = 97.4 bits (241), Expect = 2e-19 Identities = 107/430 (24%), Positives = 192/430 (44%), Gaps = 17/430 (3%) Frame = +3 Query: 354 PFL-FWFGAKPRICVFDYELVRQILSSKSGHFPKNDAHPNXXXXXXXXXXXXXXX-DWVR 527 PF+ F+ KP V D EL +QIL +F + N W Sbjct: 72 PFVGFYLFQKPAAFVIDLELAKQILIKNFSNFTDKGIYYNEKDDPMSAHLFNLDGPQWRL 131 Query: 528 HRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQELTADII 707 R + F K+K M T+VS A+ V E+ S+N+ +++ V T D+I Sbjct: 132 LRSKLSSTFTSGKMKFMYPTVVSVAEEFMAVMHEKVSENSILDVR----DLVARFTVDVI 187 Query: 708 SHTAFG---SSYKLGMEAF--YAQKELQAIAISSLLNVQIPGFSYLPTKRN--RRKWMLE 866 AFG +S + F + ++ L +L++ + + L + R ++ Sbjct: 188 GTCAFGIKCNSLRDEKAEFLHFGRRALLDSRHGNLVSGLMRSYPNLARRLGLCRNTAQIQ 247 Query: 867 KKLRSTLMRIINSRLAS--QGSGYGNDLLGLMLEGCTETEQGGKQEQLSLSMEEILHECK 1040 + + + + R + + + + L+GL + E G + L+M+EI+ + Sbjct: 248 EFYQRIVKETVTLREKENIKRNDFMDMLIGLKNQKNMTLENG--EVVKGLTMDEIVAQAF 305 Query: 1041 TFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGKGDP--SGDNLGKLKEMTMV 1214 FF AG++T+S + + ++ L+ P Q+++RAE+ + + + D + + + LK + V Sbjct: 306 VFFIAGFDTSSSTMGFALYELAKNPSIQDKVRAELGQVLEQHDQKFTYECIKDLKYLDQV 365 Query: 1215 LHETLRLYGPALFMQRKTTTDMVVGA---ITIPKEHAIVIGAPFMHRDKKVWGEDADQFN 1385 ++ETLR Y + R VV I +++I + +H D ++ E ++F Sbjct: 366 INETLRHYTIVPNVDRVAAKRFVVPGNPKFVIEAGQSVIIPSSAIHHDPSIYPE-PNEFR 424 Query: 1386 PMRFANGVARAAKVPH-ALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSPSYVH 1562 P RF+ +AK P A L F GPR CIG F ++A+ +A +++ F+F S Sbjct: 425 PERFS--PEESAKRPSVAWLPFGEGPRNCIGLRFGQMQARIGLAMLIKNFTF----SPCS 478 Query: 1563 APADFLTLRP 1592 A D LT P Sbjct: 479 ATPDPLTFDP 488
>Q9V4U9:C6A13_DROME Probable cytochrome P450 6a13 - Drosophila melanogaster (Fruit fly)| Length = 493 Score = 97.4 bits (241), Expect = 2e-19 Identities = 96/401 (23%), Positives = 174/401 (43%), Gaps = 16/401 (3%) Frame = +3 Query: 393 VFDYELVRQILSSKSGHFPKNDAHPNXXXXXXXXXXXXXXX-DWVRHRRVIDPAFAMDKI 569 + D EL+R I+ F N +W R+ + F K+ Sbjct: 82 IMDLELIRDIMIRDFSSFADRGLFHNVRDDPLTGNLLFLDGPEWRWLRQNLTQVFTSGKM 141 Query: 570 KAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQELTADIISHTAFG-------- 725 K M MV + Q + K++ F T D+I AFG Sbjct: 142 KFMFPNMVEVGEKLTQACRLQVGEIEAKDLCARF-------TTDVIGSCAFGLECNSLQD 194 Query: 726 -SSYKLGMEAFYAQKELQAIAISSLLNVQIPGFSYLPTKRNRRKWMLEKKLRSTLMRIIN 902 S M Q+ L ++ + + + F+ R R + ++ + + Sbjct: 195 PESQFRRMGRSVTQEPLHSVLVQAFM------FAQPELARKLRFRLFRPEVSEFFLDTVR 248 Query: 903 SRL--ASQGSGYGNDLLGLMLEGCTETEQGGKQEQLSLSMEEILHECKTFFFAGYETTSL 1076 L + + + NDL+ L++E E+G K +LS E+I + FF AG++T+S Sbjct: 249 QTLDYRRRENIHRNDLIQLLME---LGEEGVKD---ALSFEQIAAQALVFFLAGFDTSST 302 Query: 1077 LLTWTVFLLSVYPEWQERLRAEVLREVGKGDP--SGDNLGKLKEMTMVLHETLRLYGPAL 1250 +++ ++ L++ P+ QERLR EVL + + + + D++ ++ + V+ ETLR Y Sbjct: 303 TMSFCLYELALNPDVQERLRVEVLAVLKRNNQKLTYDSVQEMPYLDQVVAETLRKYPILP 362 Query: 1251 FMQRKTTTDMVV--GAITIPKEHAIVIGAPFMHRDKKVWGEDADQFNPMRFANGVARAAK 1424 + R++T + + + + I+I +H D +++ D ++F+P RF + A+ Sbjct: 363 HLLRRSTKEYQIPNSNLILEPGSKIIIPVHSIHHDPELY-PDPEKFDPSRFEPEEIK-AR 420 Query: 1425 VPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALS 1547 P A L F GPR CIG+ F L+ K + +L+ F F+ S Sbjct: 421 HPFAYLPFGEGPRNCIGERFGKLQVKVGLVYLLRDFKFSRS 461
>P13527:CP6A1_MUSDO Cytochrome P450 6A1 - Musca domestica (House fly)| Length = 509 Score = 97.1 bits (240), Expect = 2e-19 Identities = 103/427 (24%), Positives = 185/427 (43%), Gaps = 16/427 (3%) Frame = +3 Query: 312 VAPHFLKWRAQYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHFPKNDAHPNXXXXXXX 491 +A ++ K++ P +F G KP V D EL +++L +F + N Sbjct: 59 IADYYRKFKGSDPLPGIF-LGHKPAAVVLDKELRKRVLIKDFSNFANRGLYYNEKDDPLT 117 Query: 492 XXXXXXXXD-WVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVE 668 + W R + P F K+K M T++ Q V E+ ++ +++ Sbjct: 118 GHLVMVEGEKWRSLRTKLSPTFTAGKMKYMYNTVLEVGQRLLEVMYEKLEVSS----ELD 173 Query: 669 FDKSVQELTADIISHTAFG---SSYKLGMEAFYA--QKELQAIAISSLLNVQIPGFSYLP 833 + D+I AFG +S + + F A +K ++ ++L+ I F L Sbjct: 174 MRDILARFNTDVIGSVAFGIECNSLRNPHDRFLAMGRKSIEVPRHNALIMAFIDSFPELS 233 Query: 834 TKRNRRKWMLEKKLRSTLMRIINSRL--ASQGSGYGNDLLGLMLEGCTETEQGGKQEQLS 1007 K R +L + + M I + + + ND L L+L+ E K Sbjct: 234 RKLGMR--VLPEDVHQFFMSSIKETVDYREKNNIRRNDFLDLVLDLKNNPESISKLG--G 289 Query: 1008 LSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEV---LREVGKGDPSG 1178 L+ E+ + FF G+ET+S + + ++ L+ + Q+RLR EV + + + S Sbjct: 290 LTFNELAAQVFVFFLGGFETSSSTMGFALYELAQNQQLQDRLREEVNEVFDQFKEDNISY 349 Query: 1179 DNLGKLKEMTMVLHETLRLY--GPALFMQRKTTTDMVVG---AITIPKEHAIVIGAPFMH 1343 D L + + VL+ETLR Y G + R+T D VV +PK + I +H Sbjct: 350 DALMNIPYLDQVLNETLRKYPVGVGSALTRQTLNDYVVPHNPKYVLPKGTLVFIPVLGIH 409 Query: 1344 RDKKVWGEDADQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVL 1523 D +++ + ++F+P RF+ + + L F GPR CIG F ++++ +A V+ Sbjct: 410 YDPELY-PNPEEFDPERFSPEMVKQRDSVD-WLGFGDGPRNCIGMRFGKMQSRLGLALVI 467 Query: 1524 QKFSFAL 1544 + F F + Sbjct: 468 RHFRFTV 474
>Q29497:CP17A_SHEEP Cytochrome P450 17A1 - Ovis aries (Sheep)| Length = 509 Score = 97.1 bits (240), Expect = 2e-19 Identities = 100/443 (22%), Positives = 185/443 (41%), Gaps = 19/443 (4%) Frame = +3 Query: 321 HFLKWRAQYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHF---PKNDAHPNXXXXXXX 491 +F K + +YG + F G+K + + ++L R++L K F PK Sbjct: 52 NFFKLQEKYGPIYSFRLGSKTTVMIGHHQLAREVLLKKGKEFSGRPKVATLDILSDNQKG 111 Query: 492 XXXXXXXXDWVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEF 671 W HR+++ AFA+ K K Q + + A+++ ++ Sbjct: 112 IAFADHGAHWQLHRKLVLNAFALFK-DGNLKLEKIINQEANVLCDFLATQHGQS---IDL 167 Query: 672 DKSVQELTADIISHTAFGSSYKLGMEAFYAQKE-----LQAIAISSLLNVQIPGFSYLPT 836 + + +IIS F S+K A A + L+ + LL++ P P+ Sbjct: 168 SEPLSLAVTNIISFICFNFSFKNEDPALKAIQNVNDGILEVLGKEVLLDI-FPALKIFPS 226 Query: 837 KRNRRKWMLEKKLRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQ---GGKQEQLS 1007 K + + L I+ + S +LL ++++ + G +Q+ Sbjct: 227 KAMEKMKGCVETRNELLSEILEKCQENFTSDSITNLLHILMQAKVNADNNNTGPEQDSKL 286 Query: 1008 LSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVG-KGDPSGDN 1184 LS +L F AG ETT+ ++ W V L +P ++R++ + + +G P+ + Sbjct: 287 LSNRHMLATIADIFGAGVETTTSVIKWIVAYLLHHPSLKKRIQDSIDQNIGFNRTPTISD 346 Query: 1185 LGKLKEMTMVLHETLRLYGPA-LFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVW 1361 +L + + E LR+ A + + K D +G +TI K +V+ +H ++K W Sbjct: 347 RNRLVLLEATIREVLRIRPVAPMLIPHKAIIDSSIGDLTIDKGTDVVVNLWALHHNEKEW 406 Query: 1362 GEDADQFNPMRFANGVARAAKVPH-ALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSF 1538 + D F P RF + P + L F GPR+C+G+ A E M+ +LQ+F+ Sbjct: 407 -QQPDLFMPERFLDPTGTQLISPSLSYLPFGAGPRSCVGEMLARQELFLFMSRLLQRFNL 465 Query: 1539 ALS-----PSYVHAPADFLTLRP 1592 + PS P+ L ++P Sbjct: 466 EIPDDGKLPSLEGNPSLVLQIKP 488
>P19100:CP17A_PIG Cytochrome P450 17A1 - Sus scrofa (Pig)| Length = 509 Score = 96.7 bits (239), Expect = 3e-19 Identities = 106/444 (23%), Positives = 179/444 (40%), Gaps = 20/444 (4%) Frame = +3 Query: 321 HFLKWRAQYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHF---PKNDAHPNXXXXXXX 491 +F K + +YG F F G+K + + D++L +++L K F P+ Sbjct: 52 NFFKLQDKYGPIFSFRLGSKTTVVIGDHQLAKEVLLKKGKEFSGRPRVMTLDILSDNQKG 111 Query: 492 XXXXXXXXDWVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEF 671 W HR++ F++ K K Q + + A++N ++ Sbjct: 112 IAFADHGTSWQLHRKLALSTFSLFK-GGNLKLENIINQEIKVLCDFLATRNGE---SIDL 167 Query: 672 DKSVQELTADIISHTAFGSSYKLGMEAFYA-----QKELQAIAISSLLNVQIPGFSYLPT 836 + + +I+S F S+K G A A L A+ +L PG LP+ Sbjct: 168 AQPLSLAMTNIVSFICFNFSFKKGDPALQAIVNFNDGILDAVG-KEILYDMFPGIRILPS 226 Query: 837 KRNRRKWMLEKKLRSTLMRIINSRLASQGSGYGNDLLGLMLEGCT--ETEQGGKQEQLS- 1007 + + L I+ +R + +LL +M++ T E+ GG L Sbjct: 227 QTLENMKQCVRMRNELLREILENRKENYSRNSITNLLDIMIQAKTNAESNTGGPDHNLKL 286 Query: 1008 LSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVG-KGDPSGDN 1184 LS +L F AG ET++ ++ W V L YP +++++ + + +G PS + Sbjct: 287 LSDRHMLATVADIFGAGVETSASVVKWIVAFLLHYPLLRKKIQDAIDQNIGFNRAPSISD 346 Query: 1185 LGKLKEMTMVLHETLRL--YGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKV 1358 +L + + E LR P L R D +G TI K+ +V+ +H ++K Sbjct: 347 RNQLVLLEATIREVLRFRPVSPTLIPHR-AIIDSSIGEFTIDKDTDVVVNLWALHHNEKE 405 Query: 1359 WGEDADQFNPMRFANGVARAAKVPH-ALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFS 1535 W D F P RF + P + L F GPR+C+G+ A E A +LQ+F Sbjct: 406 W-HRPDLFMPERFLDPTGTQLISPSLSYLPFGAGPRSCVGEMLARQELFLFTAGLLQRFD 464 Query: 1536 FALS-----PSYVHAPADFLTLRP 1592 L P V P+ L + P Sbjct: 465 LELPDDGQLPCLVGNPSLVLQIDP 488
>O73853:CP17A_ICTPU Cytochrome P450 17A1 - Ictalurus punctatus (Channel catfish)| Length = 514 Score = 96.7 bits (239), Expect = 3e-19 Identities = 91/420 (21%), Positives = 175/420 (41%), Gaps = 14/420 (3%) Frame = +3 Query: 318 PH--FLKWRAQYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHF---PKNDAHPNXXXX 482 PH F + + +YG+ + G+ I V ++ +++L K F P+ Sbjct: 54 PHIFFQQLQKKYGDIYSLDMGSNRVIIVNNHHHAKEVLLRKGKIFAGRPRTVTTDILTRD 113 Query: 483 XXXXXXXXXXXDWVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQ 662 W HR+++ A M + + C +++ +++ ++ Sbjct: 114 GKDIAFGDYSATWKFHRKIVHGALCMFGEGTASIEKIICREASSMCEILTNLQSSAADLA 173 Query: 663 VEFDKSVQELTADIISHTAFGSSYKLGMEAF-----YAQKELQAIAISSLLNVQIPGFSY 827 E ++V +++ F SSYK G F Y+Q + +A SL+++ P Sbjct: 174 PELTRAV----TNVVCTLCFSSSYKRGDPEFEAMLKYSQGIVDTVAKDSLVDI-FPWLQL 228 Query: 828 LPTKRNRRKWMLEKKLRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGGKQEQ-L 1004 P + R L + A DL +L +E Q + Sbjct: 229 FPNEDLRILRRCVSIRDKLLQKKYEEHKADFSDNIQRDLFDALLRAKNSSENNNTSTQDV 288 Query: 1005 SLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGKG-DPSGD 1181 L+ + +L F AG ETT+ +L W++ L +P+ Q +++ E+ ++G+ P + Sbjct: 289 GLTDDHLLMTVGDIFGAGVETTTTVLKWSILYLIHHPQVQRKIQEELDAKIGRDRHPQVN 348 Query: 1182 NLGKLKEMTMVLHETLRLYGPA-LFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKV 1358 + G L + + E LR+ + L + +D +G T+ K +++ +H D+K Sbjct: 349 DRGNLPYLEATIREVLRIRPVSPLLIPHVALSDANIGEYTVQKGTRVIVNLWSLHHDEKE 408 Query: 1359 WGEDADQFNPMRFANGVARAAKVPH-ALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFS 1535 W ++ + FNP RF N + P + L F G R C+G+ A LE ++ +LQ+F+ Sbjct: 409 W-KNPELFNPERFLNEEGNSLCCPSLSYLPFGAGVRVCLGEALAKLELFLFLSWILQRFT 467
>P27786:CP17A_MOUSE Cytochrome P450 17A1 - Mus musculus (Mouse)| Length = 507 Score = 96.3 bits (238), Expect = 4e-19 Identities = 100/422 (23%), Positives = 177/422 (41%), Gaps = 13/422 (3%) Frame = +3 Query: 321 HFLKWRAQYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHF---PKNDAHPNXXXXXXX 491 +F K + +YG + G + V Y+L R++L K F P+ Sbjct: 52 NFFKLQEKYGPIYSLRLGTTTAVIVGHYQLAREVLVKKGKEFSGRPQMVTLGLLSDQGKG 111 Query: 492 XXXXXXXXDWVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEF 671 W HR+++ F++ + + M+ C ++ ++++ Sbjct: 112 VAFADSSSSWQLHRKLVFSTFSLFRDDQKLEKMI-CQEANSLCDLILTYDGESRDLSTLI 170 Query: 672 DKSVQELTADIISHTAFGSSYK-LGMEAFYAQKELQAIAISSLLNVQIPGFSYLPTKRNR 848 KSV + I + +F + L + + + + S L+++ F +L N+ Sbjct: 171 FKSVINIICTICFNISFENKDPILTTIQTFTEGIVDVLGHSDLVDI----FPWLKIFPNK 226 Query: 849 RKWMLEK--KLRS-TLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQ---GGKQEQLSL 1010 M+++ K+R TL+ + S + L ++++ E G Q+ Sbjct: 227 NLEMIKEHTKIREKTLVEMFEKCKEKFNSESLSSLTDILIQAKMNAENNNTGEGQDPSVF 286 Query: 1011 SMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVG-KGDPSGDNL 1187 S + IL F AG ETTS +L W + L PE + +++ E+ + VG PS ++ Sbjct: 287 SDKHILVTVGDIFGAGIETTSSVLNWILAFLVHNPEVKRKIQKEIDQYVGFSRTPSFNDR 346 Query: 1188 GKLKEMTMVLHETLRLYGPA-LFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWG 1364 L + + E LR+ A L + K D +G IPK+ ++I +H DK W Sbjct: 347 THLLMLEATIREVLRIRPVAPLLIPHKANIDSSIGEFAIPKDTHVIINLWALHHDKNEW- 405 Query: 1365 EDADQFNPMRFANGVARAAKVPH-ALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFA 1541 + D+F P RF + P + L F GPR+CIG+ A E MA +LQ+F F Sbjct: 406 DQPDRFMPERFLDPTGSHLITPTPSYLPFGAGPRSCIGEALARQELFIFMALLLQRFDFD 465 Query: 1542 LS 1547 +S Sbjct: 466 VS 467
>Q9VLZ7:C4D21_DROME Probable cytochrome P450 4d21 - Drosophila melanogaster (Fruit fly)| Length = 511 Score = 95.9 bits (237), Expect = 5e-19 Identities = 107/448 (23%), Positives = 191/448 (42%), Gaps = 30/448 (6%) Frame = +3 Query: 279 LHVRDHDYLHRVAPHFLKWRAQYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHFPKND 458 L +R +++ R +F K YG+ F W + I D + ILSS S K Sbjct: 49 LTLRPENFIQRFGDYFNK----YGKTFRLWILGECLIYTKDLKYFESILSS-STLLKKAH 103 Query: 459 AHPNXXXXXXXXXXXXXXXDWVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQAS 638 + W R+V+ PAF ++ + M G+ E+ Sbjct: 104 LYRFLRDFLGDGLLLSTGNKWTSRRKVLAPAFHFKCLENFVEIM----DRNSGIMVEKLK 159 Query: 639 KNTNKEIQVEFDKSVQELTADIISHTAFGSSYKLGMEA-FYAQKELQAI---------AI 788 + + V+ K V D+ + TA G E F K L+++ ++ Sbjct: 160 NYADGKTCVDLFKFVSLEALDVTTETAMGVQVNAQNEPNFPYTKALKSVVYIESKRLASV 219 Query: 789 SSLLNVQIPGFSYLPTKRNRRKWMLEKKLRSTLMR---IINSRLASQGSG----YGND-- 941 S N P + L +R ++ + + ++R I R + G+ G+D Sbjct: 220 SMRYNWLFPLAAPLVYRRLQKDIAIMQDFTDKVIRERRAILERARADGTYKPLIMGDDDI 279 Query: 942 -------LLGLMLEGCTETEQGGKQEQLSLSMEEILHECKTFFFAGYETTSLLLTWTVFL 1100 LL ++L+ + + LS +I E F FAG +TT+ ++ + Sbjct: 280 GGKAKMTLLDILLQATIDNKP--------LSDVDIREEVDVFIFAGDDTTTSGVSHALHA 331 Query: 1101 LSVYPEWQERLRAEVLREVGKGDPSGD----NLGKLKEMTMVLHETLRLYGPALFMQRKT 1268 +S +P+ QE + E++ +G DP L +LK + V+ ET+RL+ P + R Sbjct: 332 ISRHPKVQECIYEELVSVLGP-DPDASVTQTKLLELKYLDCVIKETMRLHPPVPILGRYI 390 Query: 1269 TTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDADQFNPMRFANGVARAAKVPHALLAF 1448 D+ +G ITIP +I++ +++RD + + D F P R+ + + P A + F Sbjct: 391 PEDLKIGEITIPGNTSILLMPYYVYRDPEYF-PDPLVFKPERWMDMKTTSNTPPLAYIPF 449 Query: 1449 SIGPRACIGQNFAMLEAKSVMATVLQKF 1532 S GP+ CIGQ FA L+ K++++ V++ + Sbjct: 450 SSGPKNCIGQKFANLQMKALISKVIRHY 477
>Q9VCW1:CP6D4_DROME Probable cytochrome P450 6d4 - Drosophila melanogaster (Fruit fly)| Length = 515 Score = 95.5 bits (236), Expect = 7e-19 Identities = 101/441 (22%), Positives = 188/441 (42%), Gaps = 30/441 (6%) Frame = +3 Query: 378 KPRICVFDYELVRQILSSKSGHFPKNDAHPNXXXXXXXXXXXXXXXD-WVRHRRVIDPAF 554 +P + + D +L R++L+ F + + W R ++ P F Sbjct: 77 RPAVLIRDADLARRVLAQDFASFHDRGVYVDEERDPLSANIFSLRGQSWRSMRHMLSPCF 136 Query: 555 AMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQELTADIISHTAFG--- 725 K+K+M T +++ + KE+ ++ K +Q DII+ T FG Sbjct: 137 TSGKLKSMFSTSEDIGDKMVAHLQKELPEEGFKEVDIK--KVMQNYAIDIIASTIFGLDV 194 Query: 726 SSYKLGMEAF-----YAQKELQAIAISSLLNVQIP---------------GFSYLPTKRN 845 +S++ F A+ + A+ ++ +P G + L + Sbjct: 195 NSFENPDNKFRKLVSLARANNRFNAMFGMMIFLVPSIAQFLFRIGFKNPVGLAMLQIVKE 254 Query: 846 RRKWMLEKKL-RSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGGKQEQLSLSMEE 1022 ++ + + R L++++ +L + G ND ++ +T G + ++S+E Sbjct: 255 TVEYREKHGIVRKDLLQLL-IQLRNTGKIDENDEKSFSIQ---KTPDGHIK---TISLEA 307 Query: 1023 ILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGKGDP--SGDNLGKL 1196 I + F+ AG ETT +T++ L+ YPE +RL+ EV + K D + D+L K+ Sbjct: 308 ITAQAFIFYIAGQETTGSTAAFTIYELAQYPELLKRLQDEVDETLAKNDGKITYDSLNKM 367 Query: 1197 KEMTMVLHETLRLYGPALFMQRKTTTDMVVGAI--TIPKEHAIVIGAPFMHRDKKVWGED 1370 + + + + ET+R Y + R+ T D V IPK +VI +H D + + D Sbjct: 368 EFLDLCVQETIRKYPGLPILNRECTQDYTVPDTNHVIPKGTPVVISLYGIHHDAEYF-PD 426 Query: 1371 ADQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSF-ALS 1547 + ++P RF+ P A + F GPR CI Q + +K + +LQ F+ +S Sbjct: 427 PETYDPERFSEESRNYN--PTAFMPFGEGPRICIAQRMGRINSKLAIIKILQNFNVEVMS 484 Query: 1548 PSYVHAPADFLTLRPKFGLPV 1610 S + + L PK G+ V Sbjct: 485 RSEIEFENSGIALIPKHGVRV 505
>Q27698:CP6D1_MUSDO Cytochrome P450 6d1 - Musca domestica (House fly)| Length = 516 Score = 95.5 bits (236), Expect = 7e-19 Identities = 103/423 (24%), Positives = 174/423 (41%), Gaps = 32/423 (7%) Frame = +3 Query: 378 KPRICVFDYELVRQILSSKSGHFPKNDAHPNXXXXXXXXXXXXXXXD-WVRHRRVIDPAF 554 KP + V D EL RQIL++ F + + W R + P+F Sbjct: 74 KPALLVRDAELARQILTTDFNSFHDRGLYVDEKNDPMSANLFVMEGQSWRTLRMKLAPSF 133 Query: 555 AMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQELTADIISHTAFGSSY 734 + K+K M +T+ A E+ + ++++ + DII FG Sbjct: 134 SSGKLKGMFETVDDVAAKLLNHLNERLKDGQSHVLEIK--SILTTYAVDIIGSVIFGLEI 191 Query: 735 K-----------LGMEAFYAQKELQAIAISSLLNVQIPGFSYLPTKRNRRKWMLEKKLRS 881 L F +K +L N P + L R K + +LR Sbjct: 192 DSFTHPDNEFRVLSDRLFNPKKSTMLQRFRNLSNFICPPLAKL-LSRLGAKDPITYRLRD 250 Query: 882 TLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGGKQEQL------------SLSMEEI 1025 + R I R + DLL L ++ + ++L ++S++ I Sbjct: 251 IVKRTIEFR--EEKGVVRKDLLQLFIQLRNTGKISDDNDKLWHDVESTAENLKAMSIDMI 308 Query: 1026 LHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEV---LREVG---KGDPSGDNL 1187 F+ AG ETT+ ++T++ L++YPE ++ ++EV L+ G +G + + + Sbjct: 309 ASNSFLFYIAGSETTAATTSFTIYELAMYPEILKKAQSEVDECLQRHGLKPQGRLTYEAI 368 Query: 1188 GKLKEMTMVLHETLRLYGPALFMQRKTTTDMVV--GAITIPKEHAIVIGAPFMHRDKKVW 1361 +K + + + ET R Y F+ RK T D V +TIPKE I+I +HRD + + Sbjct: 369 QDMKYLDLCVMETTRKYPGLPFLNRKCTQDFQVPDTKLTIPKETGIIISLLGIHRDPQYF 428 Query: 1362 GEDADQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFA 1541 + D + P RFA+ P A + F GPR CI Q ++ +K +A +L F+ Sbjct: 429 PQPED-YRPERFAD--ESKDYDPAAYMPFGEGPRHCIAQRMGVMNSKVALAKILANFNIQ 485 Query: 1542 LSP 1550 P Sbjct: 486 PMP 488
>Q9VVN6:CP312_DROME Probable cytochrome P450 312a1 - Drosophila melanogaster (Fruit fly)| Length = 510 Score = 95.5 bits (236), Expect = 7e-19 Identities = 94/358 (26%), Positives = 154/358 (43%), Gaps = 18/358 (5%) Frame = +3 Query: 519 WVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQELTA 698 W R+++ PAF M K V+ + + +K Q++F + + T Sbjct: 127 WSHRRKIVMPAFNY----TMIKQFVAVFEKQSRILLTNVAKFAESGDQIDFLQLISCFTL 182 Query: 699 DIISHTAFG----SSYKLGMEAFYAQKELQAIAISSLLNVQIPG-FSYLPTKRNRRKWML 863 D I TA G S E A K + I L N+ F + T +R+ L Sbjct: 183 DTICETALGVSVGSQSSAKSEYLDAVKSILVIIDKRLKNIFYRNSFIFKRTSHYKREQEL 242 Query: 864 EKKLRSTLMRIINSRLASQGSGYGN--------DLLGLMLEGC-TETEQGGK-QEQLSLS 1013 K L II R+ N +L G+ C +T K + L+ Sbjct: 243 IKTLHGFTEGIIQKRIDEINQDAENRNYQSSDAELDGVKRTLCFLDTLLLSKGPDGKPLT 302 Query: 1014 MEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVG--KGDP-SGDN 1184 +++I E T F G++ T+ L + ++ ++++PE Q+R R EV G K +P S + Sbjct: 303 VKDIREEVDTIIFGGFDLTATTLNFFMYNMTLHPEHQQRCREEVWSVCGKDKSEPISIEQ 362 Query: 1185 LGKLKEMTMVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWG 1364 + +L+ + + ETLR+Y RK T + + IPK ++I +M R K + Sbjct: 363 VRQLEFLEACIKETLRMYPSGPLTARKATANCTINDFFIPKGSDVIISPIYMGRCKDFF- 421 Query: 1365 EDADQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSF 1538 D F P R+A G + + F G R+C+GQ +AM+ K V+A +L+ F F Sbjct: 422 PDPMVFKPDRWAIGAEPKIEAT-TFIPFMAGARSCMGQRYAMVMLKMVLAHLLRNFLF 478
>P79760:CP1A4_CHICK Cytochrome P450 1A4 - Gallus gallus (Chicken)| Length = 530 Score = 95.5 bits (236), Expect = 7e-19 Identities = 102/472 (21%), Positives = 183/472 (38%), Gaps = 35/472 (7%) Frame = +3 Query: 309 RVAPHFLKWRA--QYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHFPKNDAHPNXXXX 482 R PH + R +YG+ G++P + + E ++Q L ++ F P+ Sbjct: 67 RKDPHLVLTRLSRKYGDVMEVTIGSRPVVVLSGLETIKQALVRQAEDFMGRPDLPSWQYV 126 Query: 483 XXXXXXXXXXX---DWVRHRRVIDPAFAMDKIKAMTKTMVSC-------------AQSTF 614 W R++ A I A SC Sbjct: 127 SNGHSLAFSYECGDAWKARRKLAQNALKTFSIAASPTASSSCLLEEHVSTEASYLVTKFL 186 Query: 615 GVFEEQASKNTNKEIQVE-------------FDKSVQELTADIISHTAFGSSYKLGMEAF 755 + EE+ S N N + V +D QEL + + +T FG G A Sbjct: 187 QLMEEKQSFNPNSYLMVSVANVICAICFGKRYDHDDQELLSVVNMNTEFGDVAAAGNPAD 246 Query: 756 YAQKELQAIAISSLLNVQIPGFSYLPTKRNRRKWMLEKKLRSTLMRIINSRLASQGSGYG 935 + IP YLP + + + + + +I+ + ++ + Sbjct: 247 F-----------------IPLLRYLPNRAMAAFKDVNARFSAFVQKIVQNHYSTFDKEHI 289 Query: 936 NDLLGLMLEGCTETEQGGKQEQLSLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYP 1115 D+ ++ C E ++ G+ ++ S E I+ F AG++T + L+W + ++YP Sbjct: 290 RDVTDSLIGHCQE-KRTGEDVRVQPSDESIISIVNDLFGAGFDTVTTALSWCMMYAALYP 348 Query: 1116 EWQERLRAEVLREVGK-GDPSGDNLGKLKEMTMVLHETLRLYGPALF-MQRKTTTDMVVG 1289 Q++++AE+ + +G+ P + G L + E R F + TT D V+ Sbjct: 349 HIQKKIQAELDQTIGRERRPRLSDRGMLPYTEAFILEAFRHSSLLPFTIPHCTTKDTVLN 408 Query: 1290 AITIPKEHAIVIGAPFMHRDKKVWGEDADQFNPMRFAN--GVARAAKVPHALLAFSIGPR 1463 IPK+ + I + D+K+W +D F P RF N G + +L F +G R Sbjct: 409 GYYIPKDTCVFINQWQANHDEKIW-KDPPSFKPERFLNAAGTELSRTEADKVLIFGLGKR 467 Query: 1464 ACIGQNFAMLEAKSVMATVLQKFSFALSPSYVHAPADFLTLRPKFGLPVVMK 1619 CIG++ E + T+LQ+ +L AP + + P++GL + K Sbjct: 468 RCIGESIGRWEVFLFLTTILQQLEISL------APGQRVDITPQYGLTMKYK 513
>P95099:CP136_MYCTU Putative cytochrome P450 136 - Mycobacterium tuberculosis| Length = 492 Score = 95.5 bits (236), Expect = 7e-19 Identities = 85/370 (22%), Positives = 159/370 (42%), Gaps = 6/370 (1%) Frame = +3 Query: 528 HRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQELTADII 707 HRR++ AF ++ + M A + + +++ LT DI Sbjct: 148 HRRIMQEAFVRSRLAGYLEQMDRVVSRVV------ADDWVVNDARFLVYPAMKALTLDIA 201 Query: 708 SHTAFGSSYKLGMEAFYAQKELQAIAISS-----LLNVQIPGFSYLPTKRNRRKWMLEKK 872 S G ++ G + K +A I++ ++ +P F+ W + Sbjct: 202 SMVFMG--HEPGTDHELVTKVNKAFTITTRAGNAVIRTSVPPFT----------WWRGLR 249 Query: 873 LRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGGKQEQLSLSMEEILHECKTFFF 1052 R L +R+ + GNDLL ++ + TE + G + S +I++ Sbjct: 250 ARELLENYFTARVKERREASGNDLLTVLCQ--TEDDDGNR-----FSDADIVNHMIFLMM 302 Query: 1053 AGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGKGDPSGDNLGKLKEMTMVLHETLR 1232 A ++T++ T + L+ +PEWQ+R R E R G G ++L +L+ + +V++E++R Sbjct: 303 AAHDTSTSTATTMAYQLAAHPEWQQRCRDESDRH-GDGPLDIESLEQLESLDLVMNESIR 361 Query: 1233 LYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDADQFNPMRFANGVA 1412 L P + R+T D + +PK ++ HR ++W D F+P RF Sbjct: 362 LVTPVQWAMRQTVRDTELLGYYLPKGTNVIAYPGMNHRLPEIW-TDPLTFDPERFTEPRN 420 Query: 1413 RAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSPSYVHAPADFLTLR- 1589 + +A F G CIG F LE K+++ +L+++ LS D+ + Sbjct: 421 EHKRHRYAFTPFGGGVHKCIGMVFDQLEIKTILHRLLRRYRLELSRPDYQPRWDYSAMPI 480 Query: 1590 PKFGLPVVMK 1619 P G+P+V++ Sbjct: 481 PMDGMPIVLR 490
>Q964R0:CP6K1_BLAGE Cytochrome P450 6k1 - Blattella germanica (German cockroach)| Length = 524 Score = 95.1 bits (235), Expect = 9e-19 Identities = 103/430 (23%), Positives = 190/430 (44%), Gaps = 37/430 (8%) Frame = +3 Query: 354 PFL-FWFGAKPRICVFDYELVRQILSSKSGHFPKNDAHPNXXXXXXXXXXXXXXXD---W 521 PF+ F+ A+P I + D +++ +L F +D H + + W Sbjct: 75 PFVGFYIFARPAILIKDPNIIKHVLVKDFNAF--SDRHASAAESDTLGSQNLFTLNGAPW 132 Query: 522 VRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQELTAD 701 R + P F ++K M + SCA+ ++ +N N + +E ++ + D Sbjct: 133 KYLRVKLSPTFTSGRMKKMYPLVESCAKQ----LQDYLKENCNTKA-IEVKETTAKYATD 187 Query: 702 IISHTAFG---SSYK--------LGMEAF----YAQKELQAIAISSLLNVQIPGFSYLPT 836 +IS AFG +S K G + F Y E+ A+ S L + G + T Sbjct: 188 VISTCAFGIESNSLKDPNAEFREFGRKIFEFTRYRTFEVMALFFSPGLVKFLNGNFF--T 245 Query: 837 KRNRRKWMLEKKLRSTLMRIINSRLASQGSGYGNDLLGLMLE----GCTETEQGGKQEQL 1004 K + LR IN R +++ S +D + L+++ G + E G E++ Sbjct: 246 KETT------EFLRKVFWDTINFRESNKISR--DDFMDLLIQLKNKGTIDNEDGEVTEKV 297 Query: 1005 S----------LSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEV--L 1148 + + ++ + FF AG+ET + L++T++ LS+ P+ Q RLR+E+ + Sbjct: 298 DKIDKDSHLFEFTGDNLVSQPALFFTAGFETNATTLSFTLYELSLQPDLQNRLRSEIAGV 357 Query: 1149 REVGKGDPSGDNLGKLKEMTMVLHETLRLYGPALFMQRKTTTDMVVGA--ITIPKEHAIV 1322 + G P+ +++ + + MV+ ETLR Y P + R D V + I ++ + Sbjct: 358 MKTSNGKPTYEDVFGMPYLHMVVSETLRKYPPLPLLDRVCLQDYKVPGTDLIIERDTPVF 417 Query: 1323 IGAPFMHRDKKVWGEDADQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAK 1502 I +HRD + + + ++++P RF+ R K + L F GP CIG F + K Sbjct: 418 IALLGLHRDPQYY-PNPERYDPERFSEENKRQRKA-YTYLPFGEGPHNCIGLRFGYMAVK 475 Query: 1503 SVMATVLQKF 1532 + + +L +F Sbjct: 476 TALVHMLAEF 485
>P33269:CP4D1_DROME Cytochrome P450 4d1 - Drosophila melanogaster (Fruit fly)| Length = 512 Score = 95.1 bits (235), Expect = 9e-19 Identities = 95/357 (26%), Positives = 159/357 (44%), Gaps = 19/357 (5%) Frame = +3 Query: 519 WVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQELTA 698 W + R++I PAF + + ++ E+ K+ + +D + T Sbjct: 127 WHKRRKIITPAFHFKILDQFVEVFEKGSRDLLRNMEQDRLKHGESGFSL-YDW-INLCTM 184 Query: 699 DIISHTAFGSSYKLGMEAFYAQKELQAI-AISSLLNVQIPGFSY--------LPTKRNRR 851 D I TA G S A + +QA+ IS +L+ ++ Y P R + Sbjct: 185 DTICETAMGVSINAQSNA--DSEYVQAVKTISMVLHKRMFNILYRFDLTYMLTPLARAEK 242 Query: 852 KWM------LEKKLRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGGKQEQLSLS 1013 K + EK + +I + + S D+ + ++ LS Sbjct: 243 KALNVLHQFTEKIIVQRREELIREGSSQESSNDDADVGAKRKMAFLDILLQSTVDERPLS 302 Query: 1014 MEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVG--KGDP-SGDN 1184 +I E TF F G++TTS L + + ++ +PE Q++ E+ VG K P S + Sbjct: 303 NLDIREEVDTFMFEGHDTTSSALMFFFYNIATHPEAQKKCFEEIRSVVGNDKSTPVSYEL 362 Query: 1185 LGKLKEMTMVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWG 1364 L +L + + + ETLR+Y + RK D + IP I I ++ R ++++ Sbjct: 363 LNQLHYVDLCVKETLRMYPSVPLLGRKVLEDCEINGKLIPAGTNIGISPLYLGRREELFS 422 Query: 1365 EDADQFNPMRFANGVARAAKV-PHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKF 1532 E + F P RF + V A K+ P+A + FS GPR CIGQ FAMLE K+++A VL+ + Sbjct: 423 EP-NSFKPERF-DVVTTAEKLNPYAYIPFSAGPRNCIGQKFAMLEIKAIVANVLRHY 477
>P70687:CP17A_MESAU Cytochrome P450 17A1 - Mesocricetus auratus (Golden hamster)| Length = 511 Score = 95.1 bits (235), Expect = 9e-19 Identities = 99/423 (23%), Positives = 176/423 (41%), Gaps = 18/423 (4%) Frame = +3 Query: 318 PH--FLKWRAQYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHFPKNDAHPNXXXXXXX 491 PH F K + +YG + G+ + + Y+L +++L K F H Sbjct: 49 PHVNFFKLQEKYGPIYSLRLGSTTTVIIGQYQLAKEVLVKKGKEF-SGRPHMVTLGLLSD 107 Query: 492 XXXXXXXXD----WVRHRRVIDPAFAM--DKIKAMTKTMVSCAQSTFGVFEEQASKNTNK 653 D W HR++ +FA+ D + + K + A S T+ Sbjct: 108 QGKGIAFADSGGSWQLHRKLALSSFALFRDGNQKLEKIICQKASSLCDFLL------THN 161 Query: 654 EIQVEFDKSVQELTADIISHTAFGSSYKLGMEAFYAQKELQAIAISSLLNVQIPG-FSYL 830 E ++ + + +II FG SY+ K ++SL N + F +L Sbjct: 162 EESIDLSEPIFNSITNIICIICFGISYENRDPILATIKSFTEGILNSLGNDHLVDIFPWL 221 Query: 831 PTKRNRRKWMLEKKLR---STLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGGKQE- 998 N+ M++K ++ L I+ S + L+ L+++ T + E Sbjct: 222 TIFPNKTVDMIKKNVKIRDEVLSGILEKCKEKFNSDSISSLMDLLIQAKTNADNNNTSEG 281 Query: 999 --QLSLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVG-KGD 1169 + S IL F AG ETT+ +L+W + L PE +++++ E+ + +G Sbjct: 282 QGSNAFSDMHILATIADIFGAGIETTASVLSWIIAFLLHNPEVKKKIQKEIDQNIGFSRT 341 Query: 1170 PSGDNLGKLKEMTMVLHETLRLYGPA-LFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHR 1346 P+ ++ L + + E LR+ A + + + +DM +G +IPK ++I +H Sbjct: 342 PTFNDRNHLLMLEATIREVLRIRPVAPMLIPHRANSDMSIGEFSIPKFTPVIINLWALHH 401 Query: 1347 DKKVWGEDADQFNPMRFANGVARAAKVPH-ALLAFSIGPRACIGQNFAMLEAKSVMATVL 1523 +K W + D+F P RF + P + L F G R+CIG+ A E MA +L Sbjct: 402 SEKEW-DQPDRFMPERFLDPTGSHLITPSLSYLPFGAGARSCIGEVLARQELFLFMAHLL 460 Query: 1524 QKF 1532 Q+F Sbjct: 461 QRF 463
>Q9VMS9:C4AC1_DROME Probable cytochrome P450 4ac1 - Drosophila melanogaster (Fruit fly)| Length = 509 Score = 94.7 bits (234), Expect = 1e-18 Identities = 93/357 (26%), Positives = 155/357 (43%), Gaps = 19/357 (5%) Frame = +3 Query: 519 WVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASK-----NTNKEIQVEFDKSV 683 W R+ + PAF + + QS G+F+E+ K N + ++E ++ + Sbjct: 139 WHSRRKALTPAFHFNVL-----------QSFLGIFKEECKKFLNVLEKNLDAELELNQVI 187 Query: 684 QELTADIISHTAFGSSYKLGMEAFYAQKELQAIAISSLLNVQIP-------GFSYLPTKR 842 T + I TA G E +K + AI + V P F Y ++ Sbjct: 188 PPFTLNNICETALGVKLDDMSEGNEYRKAIHAIEEVLIQRVCNPLMYYNWYFFVYGDYRK 247 Query: 843 NRRKWMLEKKLRSTLMRIINSRLASQGSG----YGNDLLGLMLEGCTETEQGGKQEQLSL 1010 + + + S ++ + + G +G ML+ E G+ + Sbjct: 248 HLQNLRIVHDFSSRIIERKRQQFQQKQLGEVDEFGRKQRYAMLDTLLAAEADGQ-----I 302 Query: 1011 SMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLR-EVGKGDPSGDNL 1187 + I E TF F GY+TTS L +T+ +L+++ + Q++ EV D S Sbjct: 303 DHQGICDEVNTFMFEGYDTTSTCLIFTLLMLALHEDVQKKCYEEVENLPEDSDDISMFQF 362 Query: 1188 GKLKEMTMVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGE 1367 KL + V+ E+LR++ F+ R+ + VV + +PK+ I I + RD + + + Sbjct: 363 NKLVYLECVIKESLRMFPSVPFIGRQCVEETVVNGMVMPKDTQISIHIYDIMRDPRHFPK 422 Query: 1368 DADQFNPMRFA--NGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKF 1532 D F P RF N V R P A + FS G R CIGQ FA+LE K ++A V++ F Sbjct: 423 P-DLFQPDRFLPENTVNRH---PFAYVPFSAGQRNCIGQKFAILEMKVLLAAVIRNF 475
>Q9VHP4:CP313_DROME Probable cytochrome P450 313b1 - Drosophila melanogaster (Fruit fly)| Length = 502 Score = 94.4 bits (233), Expect = 2e-18 Identities = 96/417 (23%), Positives = 178/417 (42%), Gaps = 20/417 (4%) Frame = +3 Query: 342 QYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHFPKNDAHPNXXXXXXXXXXXXXXXDW 521 Q+ PF+ W G + + D V QIL+S + K D + W Sbjct: 63 QFKAPFISWMGTSCFLYINDPHSVEQILNS-THCTNKGDFYRFMSSAIGDGLFTSSSPRW 121 Query: 522 VRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQELTAD 701 +HRR+I+PAF + + A+ E + ++ + +E + ++++ + Sbjct: 122 HKHRRLINPAFGRQILSNFLPIFNAEAEVLLQKLELEGVQHGKR---LEIYQILKKIVLE 178 Query: 702 IISHTAFGSSYKLGMEA----FYAQKELQAIAISSLLNVQI-PGFSYLPTKRNRRKWMLE 866 T G + F A L + + +L+ + P Y R + L+ Sbjct: 179 AACQTTMGKKMNFQHDGSLCIFKAYNGLTEVCVKRMLSPWLYPDLIY----RRSGLFRLQ 234 Query: 867 KKLRSTLMRIINSRL------ASQGSGYGNDLLGLMLEGCTET---EQGGKQ-EQLSLSM 1016 +K+ L I L + S + + G ++ EQ + E+ LS Sbjct: 235 QKVVGILFGFIEQLLEPIVSVVAANSNPDQQRSEMEMRGKSKAIFIEQVREHVERGQLSW 294 Query: 1017 EEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREV-GKGDPSGDNLGK 1193 +++ E A +ETTS L +T+ L+++P +QE+L E++ E+ GD + + L + Sbjct: 295 QDVRDEANVTIAATFETTSTALYFTILCLAMHPCYQEKLHKELVTELPPSGDINLEQLQR 354 Query: 1194 LKEMTMVLHETLRLYGPALFMQRKTTTDMVV----GAITIPKEHAIVIGAPFMHRDKKVW 1361 L+ MV++E +RL+ P + R D+ + G IP+ I I M RD++VW Sbjct: 355 LEYTEMVINEAMRLFAPVPMVLRSADQDIQLKRGDGEFLIPRGTQIGIDIYNMQRDERVW 414 Query: 1362 GEDADQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKF 1532 G + +NP G+ + A + F+ G R CIG +A + K ++A + + + Sbjct: 415 GPLSRTYNPDAHF-GLDSPQRHAFAFVPFTKGLRMCIGYRYAQMLMKLLLARIFRSY 470
>P51589:CP2J2_HUMAN Cytochrome P450 2J2 - Homo sapiens (Human)| Length = 502 Score = 94.4 bits (233), Expect = 2e-18 Identities = 62/181 (34%), Positives = 90/181 (49%), Gaps = 3/181 (1%) Frame = +3 Query: 1005 SLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGKG-DPSGD 1181 S E ++ FFAG ETTS L W + +++YPE QE+++AE+ R +G+G PS Sbjct: 295 SFHEENLICSTLDLFFAGTETTSTTLRWALLYMALYPEIQEKVQAEIDRVIGQGQQPSTA 354 Query: 1182 NLGKLKEMTMVLHETLRLYG-PALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKV 1358 + V+HE R+ L + R+ T D + +PK I+ +HRD Sbjct: 355 ARESMPYTNAVIHEVQRMGNIIPLNVPREVTVDTTLAGYHLPKGTMILTNLTALHRDPTE 414 Query: 1359 WGEDADQFNPMRF-ANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFS 1535 W D FNP F NG K A + FSIG RAC+G+ A E +++QKF+ Sbjct: 415 WA-TPDTFNPDHFLENG---QFKKREAFMPFSIGKRACLGEQLARTELFIFFTSLMQKFT 470 Query: 1536 F 1538 F Sbjct: 471 F 471
>Q5KQT6:CP1A2_FELCA Cytochrome P450 1A2 - Felis silvestris catus (Cat)| Length = 512 Score = 94.4 bits (233), Expect = 2e-18 Identities = 104/464 (22%), Positives = 182/464 (39%), Gaps = 35/464 (7%) Frame = +3 Query: 318 PHFLKWRA--QYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHFPKNDAHPNXXXXXXX 491 PH + R +YG+ G+ P + + + +RQ L + F PN Sbjct: 57 PHLVLARLSQRYGDVLQIRIGSTPVLVLSGLDTIRQALVQQGDDFK---GRPNLYSFSLV 113 Query: 492 XXXXXXXXD------WVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNK 653 W RR+ A I + + SC E +A + + Sbjct: 114 TDGHSMSFSPDSGPVWAARRRLAQSALNTFSIASDPASSSSCYLEDHVSKEAEALLSRLQ 173 Query: 654 EIQVE---FDKSVQEL--TADIISHTAFGSSYKLGMEAFYAQKELQAIAISSLLNVQ--- 809 E E FD Q + A++I FG + E + I + + + Sbjct: 174 EQMAEVGSFDPHSQVVLSVANVIGAMCFGQHFPQDSEEKLSLIHSSNIFVENAYSGNPVD 233 Query: 810 -IPGFSYLPTKRNRRKWMLEKKLRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQG 986 P Y+PT +R +KL L +II D+ G +L+ C ++G Sbjct: 234 FFPILQYIPTPGLQRFKAFNQKLVQFLQKIIQEHYQDFDENNIQDITGALLKHC---KKG 290 Query: 987 GKQEQLSLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGKG 1166 + + E+I+ F AG++T + ++W++ L PE Q +++ E+ VG+ Sbjct: 291 SRANGGRIPHEKIVSLINDIFGAGFDTVTTAISWSLMYLVTNPEKQRKIQEELDTVVGRA 350 Query: 1167 DPSGDNLGKLKEMTMVLHETLRLYGPALF----MQRKTTTDMVVGAITIPKEHAIVIGAP 1334 L ++ + L ++ + F + TT D + IP++H + I Sbjct: 351 --RRPRLSDRLQLPYLEASILEIFRHSSFIPFTVPHSTTRDTTLNGFYIPEKHLVFINQW 408 Query: 1335 FMHRDKKVWGEDADQFNPMRF--ANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSV 1508 ++ D+KVWG D +F P RF A+G A + ++ F +G R CIG+ A E Sbjct: 409 QVNHDQKVWG-DPFEFRPERFLTADGTAINKILSEKVMIFGLGKRRCIGEVLAKWEVFLF 467 Query: 1509 MATVLQKFSFA--------LSPSY----VHAPADFLTLRPKFGL 1604 +A +LQ+ F+ L+P Y H + + RP+F + Sbjct: 468 LAILLQQLEFSVPAGVKVDLTPIYGLTMRHVRCEHVQARPRFSI 511
>Q9N0U7:CP17A_CAPHI Cytochrome P450 17A1 - Capra hircus (Goat)| Length = 509 Score = 94.4 bits (233), Expect = 2e-18 Identities = 100/443 (22%), Positives = 184/443 (41%), Gaps = 19/443 (4%) Frame = +3 Query: 321 HFLKWRAQYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHF---PKNDAHPNXXXXXXX 491 +F K + +YG + F G+K + + ++L R++L K F PK Sbjct: 52 NFFKLQEKYGPIYSFRLGSKTTVMIGHHQLAREVLLKKGKEFSGRPKVATLDILSDNQKG 111 Query: 492 XXXXXXXXDWVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEF 671 W HR+++ AFA+ K K Q + + A+++ ++ Sbjct: 112 IAFADHGAHWQLHRKLVLNAFALFK-DGNLKLEKIINQEANVLCDFLATQHGQS---IDL 167 Query: 672 DKSVQELTADIISHTAFGSSYKLGMEAFYAQKE-----LQAIAISSLLNVQIPGFSYLPT 836 + + +IIS F S+K A A + L+ ++ LL++ P P+ Sbjct: 168 SEPLSLAVTNIISFICFNFSFKNEDPALKAIQNVNDGILEVLSKEILLDI-FPALKIFPS 226 Query: 837 KRNRRKWMLEKKLRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQ---GGKQEQLS 1007 K + + L I+ + S +LL ++++ + G Q+ Sbjct: 227 KAMEKMKGCVETRNELLNEILEKCQENFTSDSITNLLHILMQAKVNADNNNAGPDQDSKL 286 Query: 1008 LSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVG-KGDPSGDN 1184 LS +L F AG ETT+ ++ W V L +P ++R++ + + +G P+ + Sbjct: 287 LSNRHMLATIADIFGAGVETTTSVIKWIVAYLLHHPSLKKRIQDSIDQNIGFNRTPTISD 346 Query: 1185 LGKLKEMTMVLHETLRLYGPA-LFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVW 1361 L + + E LR+ A + + K D +G +TI K +V+ +H ++K W Sbjct: 347 RNCLVLLEATIREVLRIRPVAPMLIPHKAIIDSSIGDLTIDKGTDVVVNLWALHHNEKEW 406 Query: 1362 GEDADQFNPMRFANGVARAAKVPH-ALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSF 1538 + D F P RF + P + L F GPR+C+G+ A E M+ +LQ+F+ Sbjct: 407 -QQPDLFMPERFLDPTGTQLISPSLSYLPFGAGPRSCVGEMLARQELFLFMSRLLQRFNL 465 Query: 1539 ALS-----PSYVHAPADFLTLRP 1592 + PS P+ L ++P Sbjct: 466 EIPDDGKLPSLEGNPSLVLQIKP 488
>O16805:CP4D1_DROSI Cytochrome P450 4d1 - Drosophila simulans (Fruit fly)| Length = 512 Score = 94.0 bits (232), Expect = 2e-18 Identities = 95/357 (26%), Positives = 159/357 (44%), Gaps = 19/357 (5%) Frame = +3 Query: 519 WVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQELTA 698 W + R++I PAF + ++ E+ K+ + + +D + T Sbjct: 127 WHKRRKIITPAFHFKILDQFVDVFEKGSRDLLRNMEQDRLKHGDSGFSL-YDW-INLCTM 184 Query: 699 DIISHTAFGSSYKLGMEAFYAQKELQAI-AISSLLNVQIPGFSY--------LPTKRNRR 851 D I TA G S A + +QA+ IS +L+ ++ Y P R + Sbjct: 185 DTICETAMGVSINAQSNA--DSEYVQAVKTISMVLHKRMFNILYRFDLTYMLTPLARAEK 242 Query: 852 KWM------LEKKLRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGGKQEQLSLS 1013 K + EK + +I + + S D+ + ++ LS Sbjct: 243 KALNVLHQFTEKIIVQRREELIREGSSQESSKDDADVGAKRKMAFLDILLQSTVDERPLS 302 Query: 1014 MEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVG--KGDP-SGDN 1184 +I E TF F G++TTS L + + ++ +PE Q++ E+ VG K P S + Sbjct: 303 NLDIREEVDTFMFEGHDTTSSALMFFFYNIATHPEAQKKCFEEIRSVVGNDKSTPVSYEL 362 Query: 1185 LGKLKEMTMVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWG 1364 L +L + + + ETLR+Y + RK D + IP I I ++ R ++++ Sbjct: 363 LNQLHYVDLCVKETLRMYPSVPLLGRKVLEDCEINGKLIPAGTNIGISPLYLGRREELFS 422 Query: 1365 EDADQFNPMRFANGVARAAKV-PHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKF 1532 E + F P RF + V A K+ P+A + FS GPR CIGQ FAMLE K+++A VL+ + Sbjct: 423 EP-NSFKPERF-DVVTTAEKLNPYAYIPFSAGPRNCIGQKFAMLEIKAIVANVLRHY 477
>Q27712:CP2L1_PANAR Cytochrome P450 2L1 - Panulirus argus (Spiny lobster)| Length = 492 Score = 93.6 bits (231), Expect = 3e-18 Identities = 97/423 (22%), Positives = 172/423 (40%), Gaps = 21/423 (4%) Frame = +3 Query: 336 RAQYGEPFLFWFGAKPRICVFDYELVRQILSS-KSGHFPKNDAHPNXXXXXXXXXXXXXX 512 R +YG+ + G + + + +++LV+ LS + P Sbjct: 53 RKKYGDIITWRIGTRVNVFLCNFKLVKTALSKFECSDRPDFYTFKLFGEGNDVGVVFSNG 112 Query: 513 XDWVRHRRVI-----DPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDK 677 W HRR I D +++A + +C ++ K+T++ + + K Sbjct: 113 VMWQTHRRFILRQLRDLGMGKSRLEAAIQHEAAC-------LVQELKKHTDQPMPLP--K 163 Query: 678 SVQELTADIISHTAFGSSYKLGMEAFYAQKELQAIAISSLLNVQIPGFSYLP-----TKR 842 S+ ++I Y L + +L ++ + F+YLP T Sbjct: 164 SINLAVLNVIWKLVADHRYSLQDQEGQYFTQLLTTTTDNMQGFALNLFNYLPWLLMITPD 223 Query: 843 NRRKWMLEKKLRSTLMRI-------INSRLASQGSGYGNDLLGLMLEGCTETEQGGKQEQ 1001 + WM + LR + + I A+ DLL L E K++ Sbjct: 224 FVKNWMGVRVLRDGVCELKDYMKTFIKEHQATLDPSNPKDLLDAYLIDLQER----KEDP 279 Query: 1002 LS-LSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGKGD-PS 1175 LS +++E + F AG ETTS ++ WT+ L YPE Q +++ E+ V +G PS Sbjct: 280 LSTMNIETVRAVIMDLFGAGTETTSTMIRWTILYLMKYPEVQAKIQREIDAAVPRGTLPS 339 Query: 1176 GDNLGKLKEMTMVLHETLRLYG-PALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDK 1352 ++ KL +HE R+ L + T D + +PK ++ HRD Sbjct: 340 LEHKDKLAYFEATIHEVHRIVSLVPLGVSHYTNQDTELAGYRLPKGTVVMSHLECCHRDP 399 Query: 1353 KVWGEDADQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKF 1532 W E ++F P F + + K H L+ FS+G R C+G++ A +E ++ +LQ F Sbjct: 400 SYW-EKPNEFYPEHFLDDQGKFVKREH-LVNFSVGRRVCVGESLARMELFVFLSAILQNF 457 Query: 1533 SFA 1541 +F+ Sbjct: 458 TFS 460
>Q9VGB5:CP135_DROME Probable cytochrome P450 313a5 - Drosophila melanogaster (Fruit fly)| Length = 487 Score = 93.6 bits (231), Expect = 3e-18 Identities = 93/429 (21%), Positives = 187/429 (43%), Gaps = 17/429 (3%) Frame = +3 Query: 345 YGEPFLFWFGAKPRICVFDYELVRQILSSKSGHFPKNDAHPNXXXXXXXXXXXXXXXDWV 524 YG+ L W G P + + +++ I +S + + W Sbjct: 64 YGKTVLTWIGLTPVLVTCEPKILEDIFTSPNCSNRSSVVDKAISSCLGLGLLTLKNNHWN 123 Query: 525 RHRRVIDPAFAMDKIKAMTKTMVSCAQ---STFGVFEEQASKNTNKEIQVEFDKSVQELT 695 R+++ P+F + + + + + A + F + N E+ K ++T Sbjct: 124 ERRKLLLPSFKNNAVLSFVPVLNNEANFLVTLLAEFVDGGDINLLPELNKWSFKIAAQIT 183 Query: 696 -ADIISHTAFGSSYKLG--MEAFYAQKELQAIAISSLLNVQIPGFSYLPTKRNRRKWMLE 866 D + + A +Y+ G +E++ A LN IP +P RN+ L Sbjct: 184 MGDEVRNQA---NYQNGNLLESYKA------------LNNLIPIGVVMPWLRNKYLGKLF 228 Query: 867 KKLRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGGKQEQL-------SLSMEEI 1025 + L A+Q + + D++ L + + +++ LS +++ Sbjct: 229 SYEKRRL------EAATQSNAFIKDIIDKKLSSTDNSSEPALIDRILNLVRIGELSYDDV 282 Query: 1026 LHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERL---RAEVLREVGKGDPSGDNLGKL 1196 + E FA +T S+ + + L++++P++Q+ + AEV G+ + S +L KL Sbjct: 283 MGEFSNIIFAASDTLSITVNNVLILMAMFPKYQDNVFEELAEVFPSGGEFEASHADLEKL 342 Query: 1197 KEMTMVLHETLRLYGPALFMQRKTTTDMVVG-AITIPKEHAIVIGAPFMHRDKKVWGEDA 1373 ++ VLHET+RL + R+T+ + + IP+ ++I HR+K +WG A Sbjct: 343 VKLDRVLHETMRLIPAVPLLIRQTSHSIQLSNGFYIPEGVTLMIDIFHTHRNKDIWGPQA 402 Query: 1374 DQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSPS 1553 + FNP F R A+ P++ L FS G + C+G +++ AK +A +L+ ++ LS + Sbjct: 403 NAFNPDNFLPENKR-ARPPYSYLPFSKGKKTCLGWKLSLISAKLALAKILR--NYMLSTT 459 Query: 1554 YVHAPADFL 1580 +++ F+ Sbjct: 460 FLYKDLRFI 468
>Q9VGB3:CP133_DROME Probable cytochrome P450 313a3 - Drosophila melanogaster (Fruit fly)| Length = 492 Score = 93.6 bits (231), Expect = 3e-18 Identities = 98/427 (22%), Positives = 178/427 (41%), Gaps = 18/427 (4%) Frame = +3 Query: 330 KWRAQYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHFPKNDAHPNXXXXXXXXXXXXX 509 K+ YG L W G P + D ++ +I S + Sbjct: 60 KYMDIYGSTCLVWVGPTPFVITRDPKIAEEIFLSPECLNRSSIFSKPVNSCTGDGLLSLE 119 Query: 510 XXDWVRHRRVIDPAFAMDKIKAM-------TKTMVSCAQSTFGVFEEQASKNTNKEIQVE 668 WV R+ ++PAF + + + KT+V+ S G E++ + ++ Sbjct: 120 ASKWVDRRKNLNPAFKQNVLLSFLPIFNSEAKTLVAFLDSLVGQGEKKVRDDI---VRWS 176 Query: 669 FDKSVQELTA-DIISHTAFGSSYKLGMEAFYAQKELQAIAISSLLNVQIPG-----FSYL 830 F + Q D+ +F + L K + ++NV +P FS L Sbjct: 177 FRIATQTTVGTDVKKDASFKNDSVL--------KSYETFMKIIVMNVLLPFTHNKIFSTL 228 Query: 831 PTKRNRRKWMLEKKLRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGGKQEQLSL 1010 + K + + + + I++ +L ++ + ++ E + G+ + Sbjct: 229 GGFETQ-KALAKSNVNKMIGTIVDKKLMTKPESGSQPEITSVINKAIELHRNGE-----M 282 Query: 1011 SMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREV----GKGDPSG 1178 S EE+ EC +F A +ETT + + LL+++PE Q+ + E L+E+ G + + Sbjct: 283 SREEVQSECCSFVVAAFETTGDTVYHALILLAMFPEHQDTVYQE-LKELFPVAGDFEVTY 341 Query: 1179 DNLGKLKEMTMVLHETLRLYGPALFMQRKTTTDM-VVGAITIPKEHAIVIGAPFMHRDKK 1355 D+L ++ + V++ETLRL F R+T D + + IPK I I HR++ Sbjct: 342 DDLQRMVFLERVVNETLRLIPSVPFTPRETIRDFRLSSGVVIPKGVGIGIDIFATHRNRD 401 Query: 1356 VWGEDADQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFS 1535 WG D FNP F R + P+A + FS G R CIG + ++ +K ++ +L+ Sbjct: 402 HWGTDPSSFNPDHFLPDNVR-DRHPYAYIPFSKGRRNCIGWKYGLMSSKLALSKILRNCK 460 Query: 1536 FALSPSY 1556 + S Y Sbjct: 461 VSTSFRY 467
>Q9VGB4:CP132_DROME Probable cytochrome P450 313a2 - Drosophila melanogaster (Fruit fly)| Length = 493 Score = 93.6 bits (231), Expect = 3e-18 Identities = 94/421 (22%), Positives = 178/421 (42%), Gaps = 16/421 (3%) Frame = +3 Query: 342 QYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHFPKNDAHPNXXXXXXXXXXXXXXXDW 521 ++G ++ W G P + D ++ ++L+S + W Sbjct: 64 KHGSTYMAWIGTTPIVITRDPKIAEKVLTSPFCINRSSQTTNALALSMGYGLLTLQGSKW 123 Query: 522 VRHRRVIDPAFAMDKI-------KAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKS 680 + R+ ++PAF + A T +VS S G E+ + I+ F + Sbjct: 124 MARRKHMNPAFKHSVLLSFLPIFNAETDLLVSVFDSFVGQGEKDVLSDL---IRWSFAIA 180 Query: 681 VQE-LTADIISHTAFGSSYKLGMEAFYAQKELQAIAISSLLNVQIPGF-SYLPTKRNRRK 854 Q L D+ F + L K Q++ +++N+ +P + + +K + Sbjct: 181 TQTTLGTDVTKDDNFENDAIL--------KTYQSMLRLTIINIFVPFVQNKIVSKLFGLE 232 Query: 855 WMLEKK---LRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGGKQEQLSLSMEEI 1025 W+ + + + I++ +L S Y L ++ E + + +S+ E+ Sbjct: 233 WLRRRDASAINKMINNILDKKLNSNPENYCESELKTVIHRAIELFRNDE-----MSLMEL 287 Query: 1026 LHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLRE--VGKG-DPSGDNLGKL 1196 EC + A +ET++ + + + LL+++PE QE + E+ + KG + + +L +L Sbjct: 288 GAECSSMVLAAFETSAHTVYYALVLLAMFPEHQEMVFNEIKEHFPLAKGIEVTHTDLQQL 347 Query: 1197 KEMTMVLHETLRLYGPALFMQRKTTTDM-VVGAITIPKEHAIVIGAPFMHRDKKVWGEDA 1373 + VL+ETLRL F R+T D+ + + IPK I I R+ WG +A Sbjct: 348 VYLDRVLNETLRLMPSVPFSSRETLEDLRLSNGVVIPKGMTISIDIFNTQRNTDYWGSEA 407 Query: 1374 DQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSPS 1553 QFNP F + P+A + FS G R CIG + ++ +K + +L+ + S Sbjct: 408 AQFNPENFLPEKIH-DRHPYAFIPFSKGKRNCIGWRYGLMSSKLALVKILRNYKLKTSFP 466 Query: 1554 Y 1556 Y Sbjct: 467 Y 467
>O46051:C4D14_DROME Probable cytochrome P450 4d14 - Drosophila melanogaster (Fruit fly)| Length = 507 Score = 93.6 bits (231), Expect = 3e-18 Identities = 104/407 (25%), Positives = 175/407 (42%), Gaps = 29/407 (7%) Frame = +3 Query: 399 DYELVRQILSSKSGHFPKNDAHPNXXXXXXXXXXXXXXXDWVRHRRVIDPAFAMDKIKAM 578 D +++ I+SS+ KN+ + W R R++I PAF ++ Sbjct: 85 DSKMIEAIMSSQQT-IQKNNLYSLLVNWLGDGLLISQGKKWFRRRKIITPAFHFKILEDF 143 Query: 579 TKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQEL-------TADIISHTAFGSSY- 734 + VF++Q++ K K+V + DII+ TA G Sbjct: 144 VE-----------VFDQQSATMVQKLYDRADGKTVINMFPVACLCAMDIIAETAMGVKIN 192 Query: 735 -KLGMEAFYAQKELQAIAI------SSLLNVQIPGFSYLPTKRNRRKWMLEKKLRSTLMR 893 +L + Y Q A A+ + L + + P ++ + K + Sbjct: 193 AQLQPQFTYVQSVTTASAMLAERFMNPLQRLDFTMKLFYPKLLDKLNDAV-KNMHDFTNS 251 Query: 894 IINSR--LASQGSGYGNDLLGLMLEGCTETEQGGKQEQL--------SLSMEEILHECKT 1043 +I R L + G D +L + + + L LS ++I E T Sbjct: 252 VITERRELLQKAIADGGDADAALLNDVGQKRRMALLDVLLKSTIDGAPLSNDDIREEVDT 311 Query: 1044 FFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVG--KGDP-SGDNLGKLKEMTMV 1214 F F G++TT+ + +T +LL+ +PE Q R+ EV +G K P + LG+LK + V Sbjct: 312 FMFEGHDTTTSSIAFTCYLLARHPEVQARVFQEVRDVIGDDKSAPVTMKLLGELKYLECV 371 Query: 1215 LHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDADQFNPMR 1394 + E+LRL+ + R + D V+ IP + ++I RD + D ++F P R Sbjct: 372 IKESLRLFPSVPIIGRYISQDTVLDGKLIPADSNVIILIYHAQRDPDYF-PDPEKFIPDR 430 Query: 1395 FANGVARAAKV-PHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKF 1532 F+ + R ++ P A FS GPR CIGQ FAMLE KS ++ +++ F Sbjct: 431 FS--MERKGEISPFAYTPFSAGPRNCIGQKFAMLEMKSTISKMVRHF 475
>Q95328:CP17A_HORSE Cytochrome P450 17A1 - Equus caballus (Horse)| Length = 508 Score = 93.2 bits (230), Expect = 3e-18 Identities = 94/422 (22%), Positives = 173/422 (40%), Gaps = 16/422 (3%) Frame = +3 Query: 318 PH--FLKWRAQYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHF---PKNDAHPNXXXX 482 PH F K + +YG + G K + V Y+L +++L K F P+ Sbjct: 49 PHVNFFKLQKKYGPIYSLRMGTKTTVMVGHYQLAKEVLIKKGKEFSGRPQVATLNILSDN 108 Query: 483 XXXXXXXXXXXDWVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQ 662 W HR+++ AFA+ K + C +++ + + A++N Sbjct: 109 QKGVAFADHGAPWQLHRKLVRAAFALFKDGNQKLEKIICHETSL-LCDLLATQNGQT--- 164 Query: 663 VEFDKSVQELTADIISHTAFGSSYKLGMEAF-----YAQKELQAIAISSLLNVQIPGFSY 827 ++ + ++I F SSY G A Y + L+ + +++++ P Sbjct: 165 IDLSSPLFLAVTNVICWICFNSSYMKGDPALETMQNYHKGILETLEKDNVVDI-FPALKI 223 Query: 828 LPTKRNRRKWMLEKKLRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQ---GGKQE 998 P K + L +I + S +L L+++ ++ G Q+ Sbjct: 224 FPNKSLEKMRHCVNIRNELLSKIFEKHKENFNSDSITSMLDLLIQAKKNSDNNNTGPDQD 283 Query: 999 QLSLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVG-KGDPS 1175 LS + IL F AG ETT+ ++ W V L P+ +++++ E+ + VG P+ Sbjct: 284 SKLLSDKHILATIGDIFGAGVETTTSVVKWIVAFLLHDPQLKKKIQEEIDQNVGFSRTPT 343 Query: 1176 GDNLGKLKEMTMVLHETLRLYGPA-LFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDK 1352 + +L + + E LR+ A + + K D +G + ++I +H ++ Sbjct: 344 LSDRNRLLLLEATIREVLRIRPVAPMLIPHKALVDSSIGEFAVDDGTNVIINLWALHHNE 403 Query: 1353 KVWGEDADQFNPMRFANGVARAAKVPH-ALLAFSIGPRACIGQNFAMLEAKSVMATVLQK 1529 K W D+F P RF + P + L F GPR+CIG+ A E A +LQ+ Sbjct: 404 KEW-HQPDRFMPERFLDPTGSQLISPSLSYLPFGAGPRSCIGELLARQELFLFTAWLLQR 462 Query: 1530 FS 1535 F+ Sbjct: 463 FN 464
>Q9V776:CP317_DROME Probable cytochrome P450 317a1 - Drosophila melanogaster (Fruit fly)| Length = 518 Score = 92.8 bits (229), Expect = 4e-18 Identities = 94/415 (22%), Positives = 177/415 (42%), Gaps = 20/415 (4%) Frame = +3 Query: 363 FWFGAKPRICVFDYELVRQILSSKSGHFPKNDAHPNXXXXXXXXXXXXXXXD-WVRHRRV 539 F+ +PR + D EL+RQI+ +F + N + W R+ Sbjct: 81 FYALLQPRALILDRELIRQIMIKDFWNFNDRGLYCNQKSDPLSGDLYALRGESWKEMRQK 140 Query: 540 IDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQELTADIISHTA 719 +DP+ D++ + + A+ + + ++ K ++ ++ Sbjct: 141 LDPSLEGDRMSLLYDCLYEEAEQLLLTVNSTLMSQPHSTVHIQ--KIMRRYVLSSLAKCV 198 Query: 720 FGSSYK----LGMEAFYAQKELQAIA-----ISSLLNVQIPGFSYLPTKRNRRKWMLEKK 872 FG + + +E F EL + + +L+ ++ P F + R K E+ Sbjct: 199 FGLNAEQRKTYPLEDFEQMTELALNSHKHGYLMNLMMIRFPNFCRMLRMRRTPK-QAEEY 257 Query: 873 LRSTLMRIINSRLASQGSGYGNDLLGLM-----LEGCTETEQGGKQEQLSLSMEEILHEC 1037 L I+ R S D L L+ LE T + K+ L E H Sbjct: 258 FIKLLTSIVEQRETSGKPQ--KDYLQLLIDVKALEFITYQYEADKELGAHLQNELAAH-A 314 Query: 1038 KTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGK--GDPSGDNLGKLKEMTM 1211 F AGYE T+ L++ ++ L+++PE Q R+R EV + + + G + + + L M Sbjct: 315 DVFLKAGYEQTANTLSYVLYELALHPELQVRVREEVKKAIERHDGHITHEGIKSLSFMGQ 374 Query: 1212 VLHETLRLYGPALFMQRKTTTDMVV---GAITIPKEHAIVIGAPFMHRDKKVWGEDADQF 1382 V++ETLR++ ++ R+T D V + KE ++I +H D ++ D ++F Sbjct: 375 VINETLRMHPITPYILRRTLNDYAVPDHPKYILVKELFLIIPTHAIHHDPDIY-PDPEEF 433 Query: 1383 NPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALS 1547 P R+ +G + + F +G R+CIG FA L+ + +A +L ++ F+L+ Sbjct: 434 KPDRW-SGPRDSLQEQGTWFGFGVGARSCIGIQFAQLQLRLALALLLSEYEFSLN 487
>Q9GQM9:CP6L1_BLAGE Cytochrome P450 6l1 - Blattella germanica (German cockroach)| Length = 503 Score = 92.4 bits (228), Expect = 6e-18 Identities = 98/415 (23%), Positives = 172/415 (41%), Gaps = 27/415 (6%) Frame = +3 Query: 363 FWFGAKPRICVFDYELVRQILSSKSGHFPKN--DAHPNXXXXXXXXXXXXXXXDWVRHRR 536 F+ +P + V D L++ IL +F ++ + W + R Sbjct: 75 FYIFGRPALLVRDPSLLQHILVKDFSNFTDRLTSSNKHKDPVGAANLFCIKGNRWRQIRA 134 Query: 537 VIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTN-KEIQVEFDKSVQELTADIISH 713 I F+ ++K M +++ A T E+ ++ N K++ V + D + Sbjct: 135 CITHTFSTARLKIMFSRVLNSASVTRDYILERGNQPINVKDLFVR-------TSLDSMCS 187 Query: 714 TAFGSSYKLGMEAFYAQKELQAIAISSLLNVQIPGFSYLPTKRNRRKWMLEKKLRST--- 884 T FG I S+L N + +L +W + L + Sbjct: 188 TLFG------------------IESSTLYNSEA---QFLHYGHKMMRWTPYRALEALAHF 226 Query: 885 ----LMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGG-------------KQEQLSLS 1013 L+ + ++RL S L+ E TE E+ G K++ + +S Sbjct: 227 FSPELLNVFDTRLFECEST--EFLINAFSEAITEREKTGLYCSDLVDSLIQLKKQLIDVS 284 Query: 1014 MEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEV--LREVGKGDPSGDNL 1187 E+L + FF AG+ETTS + + ++ L+++PE Q+RLR E+ + G + + + Sbjct: 285 EHEVLGQAMLFFAAGFETTSSAMAFAMYELALHPEIQDRLRTEIQEVTACHGGQVTYEGV 344 Query: 1188 GKLKEMTMVLHETLRLYGPALFMQRKTTTDMVVGA--ITIPKEHAIVIGAPFMHRDKKVW 1361 K+ + MV+ E LR Y P F+ R D + + I K I + +HRD ++ Sbjct: 345 KKMSYLDMVVSEVLRKYPPMSFIDRVCLHDYHIPGTDVVIEKGTPIFVSLLGLHRD-SIF 403 Query: 1362 GEDADQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQ 1526 D + FNP RF N ++ P + + F GPR CIG ++ K V+ +LQ Sbjct: 404 YPDPEDFNPERF-NKEKKSGVHPFSYIPFGDGPRNCIGLRLGLMSVKLVIIMLLQ 457
>Q964R1:CP6J1_BLAGE Cytochrome P450 6j1 - Blattella germanica (German cockroach)| Length = 501 Score = 92.4 bits (228), Expect = 6e-18 Identities = 99/398 (24%), Positives = 170/398 (42%), Gaps = 13/398 (3%) Frame = +3 Query: 378 KPRICVFDYELVRQILSSKSGHFPKN--DAHPNXXXXXXXXXXXXXXXDWVRHRRVIDPA 551 +P + V D E+V+ IL S +F + W R + P Sbjct: 84 QPALLVNDLEIVKNILVKDSRNFIDRMVKVDESLSPLNANAIFALRGQKWKHVRTSLTPT 143 Query: 552 FAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQELTADIISHTAFGSS 731 F K+K M + C Q +F E+ +K N V +V+ T D+ + AFG Sbjct: 144 FTTGKMKNMFYLVDKCGQQLV-LFIEKFAKAENP---VAVKDAVERFTMDVTAMCAFGIE 199 Query: 732 YKLGME--AFYAQKELQAIAISSLLNVQIPGFSYLPTKRN--RRKWM---LEKKLRSTLM 890 + A ++ + +S V + P +N R K M +E ++R + Sbjct: 200 CNSLQDPKAEFSNLLHRIFQLSFTSAVANLATFFAPWVQNFFRLKLMDSEIEDRIRDIVW 259 Query: 891 RIINSRLASQGSGYGNDLLGLMLEGCTETEQGGKQEQLSLSMEEILHECKTFFFAGYETT 1070 R ++ R + NDLL ++E T E L ++ + + F AG+ T+ Sbjct: 260 RAVHLR--EKTGEKRNDLLDYLMELRTS-------ETSKLDGDDFVAQAFGFLVAGFHTS 310 Query: 1071 SLLLTWTVFLLSVYPEWQERLRAEV--LREVGKGDPSGDNLGKLKEMTMVLHETLRLYGP 1244 S+ LT+ ++ LSV+ + Q R E+ + E K + ++ +K + MV++ETLR Y Sbjct: 311 SMTLTFALYELSVHQDIQTTARTEIKDVLEHHKKKVTYYSIKDMKYLDMVVNETLRKYPA 370 Query: 1245 ALFMQRKTTTDM-VVGAITIPKEHAIVIGAPFMHRDKKVWGEDADQFNPMRFANGVARAA 1421 F+ R+ D + + +P + I +H D K + A +F+P RF+ Sbjct: 371 IPFLDRRCQEDYPLTQDLMLPAGTGVYIPVYALHHDSKYFPSPA-KFDPERFSE--KNKQ 427 Query: 1422 KVPH-ALLAFSIGPRACIGQNFAMLEAKSVMATVLQKF 1532 +PH A + F GPR CIG F ++ K+ + +L F Sbjct: 428 NIPHFAYMPFGEGPRNCIGMRFGSMQVKAALIHILSNF 465
>Q9CX98:CP2U1_MOUSE Cytochrome P450 2U1 - Mus musculus (Mouse)| Length = 530 Score = 92.4 bits (228), Expect = 6e-18 Identities = 103/434 (23%), Positives = 176/434 (40%), Gaps = 14/434 (3%) Frame = +3 Query: 285 VRDHDYLHRVAPHFLKWRAQYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHFPKNDAH 464 V H YL R+A YG F F+ G + + + D+ VR+ L ++ F Sbjct: 87 VGQHVYLARMA-------RVYGNIFSFFIGHRLVVVLSDFHSVREALVQQAEVFSDRPRM 139 Query: 465 P--NXXXXXXXXXXXXXXXDWVRHRRVIDPA---FAMDKIKAMTKTMVSCAQSTFGVFEE 629 P + W + RR F + K+ + + F +E Sbjct: 140 PLISIMTKEKGIVFAHYGPIWKQQRRFSHSTLRHFGLGKLSLEPRII-----EEFAYVKE 194 Query: 630 QASKNTNKEIQVEFDKSVQELTADIISHTAFGSSYKLGMEAF-----YAQKELQAIAISS 794 K+ E + ++II FG + + F + + L+ S Sbjct: 195 AMQKHG--EAPFSPFPIISNAVSNIICSLCFGQRFDYTNKEFKKVLDFMSRGLEICLHSQ 252 Query: 795 LLNVQI-PGFSYLPTKRNRRKWMLEKKLRSTLMRIINSRLASQGSGYGNDLLGLMLEGCT 971 L + I P F YLP + +E+ + L II S + D + + L Sbjct: 253 LFLINICPWFYYLPFGPFKELRQIERDISCFLKNIIREHQESLDASNPQDFIDMYLLHME 312 Query: 972 ETEQGGKQEQLSLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLR 1151 E EQG + S + + + F AG +TT+ L W + +S+ P+ Q+++ E+ R Sbjct: 313 E-EQGASRRS-SFDEDYLFYIIGDLFIAGTDTTTNSLLWCLLYMSLNPDVQKKVHEEIER 370 Query: 1152 EVG-KGDPSGDNLGKL--KEMTMVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIV 1322 +G PS + ++ E T++ + L + P L + T+ V+ TIPK ++ Sbjct: 371 VIGCDRAPSLTDKAQMPYTEATIMEVQRLSMVVP-LAIPHMTSEKTVLQGFTIPKGTVVL 429 Query: 1323 IGAPFMHRDKKVWGEDADQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAK 1502 I +HRD +W E D F P RF + + K + F IG R C+G+ A +E Sbjct: 430 INLWSVHRDPAIW-EKPDDFCPHRFLDDQGQLLK-RETFIPFGIGKRVCMGEQLAKMELF 487 Query: 1503 SVMATVLQKFSFAL 1544 + +++Q F+FAL Sbjct: 488 LMFVSLMQTFTFAL 501
>O54750:CP2J6_MOUSE Cytochrome P450 2J6 - Mus musculus (Mouse)| Length = 501 Score = 92.4 bits (228), Expect = 6e-18 Identities = 87/325 (26%), Positives = 138/325 (42%), Gaps = 20/325 (6%) Frame = +3 Query: 678 SVQELTADIISHTAFGSSYKLGMEAFYAQKEL-------QAIAISSLLNVQIPGFSYLPT 836 S+ ++II FG + F L + IS L N+ Y+P Sbjct: 183 SINNAVSNIICSVTFGERFDYHDSRFQEMLRLLDEVMYLETTMISQLYNIFPWIMKYIPG 242 Query: 837 KRNR--RKWMLEKKLRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGGKQEQLSL 1010 + R W +KL+ + +I+ D + L+ T+ + + S Sbjct: 243 SHQKVFRNW---EKLKLFVSCMIDDHRKDWNPDEPRDFIDAFLKEMTKYPE----KTTSF 295 Query: 1011 SMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGKGDPSGDNLG 1190 + E ++ FFAG ETTS L W + +++YPE QE+++AE+ R +G+ L Sbjct: 296 NEENLICSTLDLFFAGTETTSTTLRWALLYMALYPEVQEKVQAEIDRVIGQ--KRAARLA 353 Query: 1191 KLKEM---TMVLHETLRLYG-PALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKV 1358 + M V+HE R+ L + R+ D + +PK ++ +HRD K Sbjct: 354 DRESMPYTNAVIHEVRRMGNIIPLNVPREVAMDTNLNGFHLPKGTMVLTNLTALHRDPKE 413 Query: 1359 WGEDADQFNPMRF-ANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFS 1535 W D FNP F NG K + L FS+G RAC+G+ A E +++QKF+ Sbjct: 414 WA-TPDVFNPEHFLENG---QFKKRESFLPFSMGKRACLGEQLARSELFIFFTSLMQKFT 469 Query: 1536 F------ALSPSYVHAPADFLTLRP 1592 F LSP + + LTL P Sbjct: 470 FNPPINEKLSPKFRNG----LTLSP 490
>Q9V3S0:CP4G1_DROME Cytochrome P450 4g1 - Drosophila melanogaster (Fruit fly)| Length = 556 Score = 92.0 bits (227), Expect = 8e-18 Identities = 101/445 (22%), Positives = 188/445 (42%), Gaps = 48/445 (10%) Frame = +3 Query: 342 QYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHFPKNDAHPNXXXXXXXXXXXXXXXDW 521 +YGE W G + + + + ILS H K + + W Sbjct: 90 KYGETMKAWLGNVLLVFLTNPSDIELILSGHQ-HLTKAEEYRYFKPWFGDGLLISNGHHW 148 Query: 522 VRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQELTAD 701 HR++I P F +K+ T V +++ +A K+ + + + T D Sbjct: 149 RHHRKMIAPTFHQSILKSFVPTFVDHSKAVVARMGLEAGKS------FDVHDYMSQTTVD 202 Query: 702 IISHTAFG-SSYKLGMEAF-YAQKELQAIAISSLLNVQ-------IPGFSYLPTKRNR-- 848 I+ TA G G ++F YAQ + I V+ I F+ L K +R Sbjct: 203 ILLSTAMGVKKLPEGNKSFEYAQAVVDMCDIIHKRQVKLLYRLDSIYKFTKLREKGDRMM 262 Query: 849 -------------RKWMLEKKLRSTLMRI---INSRLASQGSGYGNDLLGL--------- 953 RK +++ R+ + I + S AS+ G +DL + Sbjct: 263 NIILGMTSKVVKDRKENFQEESRAIVEEISTPVASTPASKKEGLRDDLDDIDENDVGAKR 322 Query: 954 ---MLEGCTETEQGGKQEQLSLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQ 1124 +L+ E K + + ++I+ E T F G++TTS ++ + ++ ++ + Q Sbjct: 323 RLALLDAMVEM---AKNPDIEWNEKDIMDEVNTIMFEGHDTTSAGSSFALCMMGIHKDIQ 379 Query: 1125 ERLRAEVLREVGKG---DPSGDNLGKLKEMTMVLHETLRLYGPALFMQRKTTTDMVV--G 1289 ++ AE G D + + ++K + V+ ETLRLY P + R+ D+ + G Sbjct: 380 AKVFAEQKAIFGDNMLRDCTFADTMEMKYLERVILETLRLYPPVPLIARRLDYDLKLASG 439 Query: 1290 AITIPKEHAIVIGAPFMHRDKKVWGE----DADQFNPMRFANGVARAAKVPHALLAFSIG 1457 T+PK +++ +HR ++ D D F P R AN + ++ + FS G Sbjct: 440 PYTVPKGTTVIVLQYCVHRRPDIYPNPTKFDPDNFLPERMAN------RHYYSFIPFSAG 493 Query: 1458 PRACIGQNFAMLEAKSVMATVLQKF 1532 PR+C+G+ +AML+ K +++T+++ + Sbjct: 494 PRSCVGRKYAMLKLKVLLSTIVRNY 518
>P79761:CP1A5_CHICK Cytochrome P450 1A5 - Gallus gallus (Chicken)| Length = 528 Score = 92.0 bits (227), Expect = 8e-18 Identities = 96/438 (21%), Positives = 174/438 (39%), Gaps = 26/438 (5%) Frame = +3 Query: 309 RVAPHFLKWRA--QYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHF---PKNDAHPNX 473 R PH + R +YG+ G++P + + E ++Q L ++ F P + + Sbjct: 65 RKDPHLVLTRLSRKYGDVMEVTIGSRPVVVLSGLETIKQALVRQAEDFMGRPDLYSFRHI 124 Query: 474 XXXXXXXXXXXXXXDWVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNK 653 W R++ A I A SC +AS K Sbjct: 125 TDGQSLTFSTDTGEMWKARRKLAQNALKNFSIAASPTASSSCLLEEH--VSTEASYLVTK 182 Query: 654 EIQVEFDKSVQE-------LTADIISHTAFGSSYKLGMEAFYAQKELQAIA--ISSLLNV 806 +Q+ +K + A++I FG Y + +EL ++ + ++V Sbjct: 183 FLQLMEEKQSFDPYRYMVVSVANVICAICFGKRYD------HDDQELLSVVNVVDEFVDV 236 Query: 807 Q--------IPGFSYLPTKRNRRKWMLEKKLRSTLMRIINSRLASQGSGYGNDLLGLMLE 962 IP YLP++ K+ L + + D+ ++E Sbjct: 237 TAAGNPADFIPLLRYLPSRNMDSFLDFNKRFMKLLQTAVEEHYQTFDKNNIRDVTDSLIE 296 Query: 963 GCTETEQGGKQEQLSLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAE 1142 C E ++ + E+I++ F AG++T + L+W++ L YP Q++++AE Sbjct: 297 QCVE-KKAEANGATQIPNEKIINLVNDIFGAGFDTVTTALSWSLMYLVTYPHMQKKIQAE 355 Query: 1143 VLREVGK-GDPSGDNLGKLKEMTMVLHETLRLYGPALF-MQRKTTTDMVVGAITIPKEHA 1316 + + +G+ P + G L + E R F + TT D V+ IPK+ Sbjct: 356 LDQTIGRERRPRLSDRGMLPYTEAFILEMFRHSSFMPFTIPHSTTRDTVLNGYYIPKDRC 415 Query: 1317 IVIGAPFMHRDKKVWGEDADQFNPMRFANGVARAAKVPHA--LLAFSIGPRACIGQNFAM 1490 + I ++ D+K+W +D FNP RF N A ++ F +G R CIG+N Sbjct: 416 VFINQWQVNHDEKLW-KDPQAFNPERFLNAEGTEVNKVDAEKVMTFGLGKRRCIGENIGK 474 Query: 1491 LEAKSVMATVLQKFSFAL 1544 E ++T+LQ+ F++ Sbjct: 475 WEVFLFLSTLLQQLEFSI 492
>Q9W130:CP9C1_DROME Cytochrome P450 9c1 - Drosophila melanogaster (Fruit fly)| Length = 522 Score = 91.7 bits (226), Expect = 1e-17 Identities = 91/387 (23%), Positives = 169/387 (43%), Gaps = 32/387 (8%) Frame = +3 Query: 519 WVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQELTA 698 W + R + P F KI+ M + + C + Q T+ ++E T Sbjct: 131 WKQMRSTLTPTFTSLKIRQMFELIHFCNVEAVDFVQRQLDAGTS---ELELKDFFTRYTN 187 Query: 699 DIISHTAFG---SSYKLGMEAFYA-QKELQAIAISSLLNVQIPGFSYLPTKRNRRKWMLE 866 D+I+ AFG +S+K F++ + + L V + + +P L Sbjct: 188 DVIATAAFGIQVNSFKDPNNEFFSIGQRISEFTFWGGLKVML--YILMPK--------LM 237 Query: 867 KKLRSTLMRIIN-----------SRLASQGSGYGNDLLGLMLEGCTE--------TEQGG 989 K LR +M + N + + S D++ L++E + E Sbjct: 238 KALRVPVMDMNNVDYFKKLVFGAMKYRKEQSIVRPDMIHLLMEAQRQFKAEQEGSAESAA 297 Query: 990 KQEQLSLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVL---REVG 1160 +Q++ + +++L +C FF AG+ET + L++T + L + PE QE+L AE+L ++G Sbjct: 298 QQDKAEFNDDDLLAQCLLFFSAGFETVATCLSFTSYELMMNPEVQEKLLAEILAVKEQLG 357 Query: 1161 KGDPSGDNLGKLKEMTMVLHETLRLYGPALFMQRKTTTDMVVG------AITIPKEHAIV 1322 + D L +K + V+ E+LR + PA + R +D + + + ++ + Sbjct: 358 EKPLDYDTLMGMKYLNCVVSESLRKWPPAFIVDRMCGSDFQLKDEEGEVVVNLREDDLVH 417 Query: 1323 IGAPFMHRDKKVWGEDADQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAK 1502 I +H D + E +QF P RF + L F +G R+CIG A++E K Sbjct: 418 INVGALHHDPDNFPE-PEQFRPERFDEEHKHEIR-QFTYLPFGVGQRSCIGNRLALMEVK 475 Query: 1503 SVMATVLQKFSFALSPSYVHAPADFLT 1583 S++ ++ ++ L P+ PAD ++ Sbjct: 476 SLIFQLVLRYH--LKPT-DRTPADMMS 499
>Q95036:CP6B5_PAPGL Cytochrome P450 6B5 - Papilio glaucus (Tiger swallowtail butterfly)| Length = 476 Score = 91.3 bits (225), Expect = 1e-17 Identities = 90/353 (25%), Positives = 157/353 (44%), Gaps = 13/353 (3%) Frame = +3 Query: 519 WVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQELTA 698 W R+ P F K+K M M F + K +KE + + V++ T Sbjct: 123 WRVLRQCFTPLFTSGKLKNMLNLMSDRGDK----FIKMVEKICDKEPEQQIIPLVRKFTM 178 Query: 699 DIISHTAFGSSYKLGMEAFYAQKELQAIAISSLLNVQIPGFSYLPTKRNRRKWMLEKKLR 878 I+ AFG +L E +L ++ ++ +I Y + + K + Sbjct: 179 ASITTCAFGM--ELDEEMIETLDKLDSLIFTTSYGNEID-MMYPGILKKLNSSLFSKMIA 235 Query: 879 STLMRIINSRLASQGSGYGN--DLLGLMLE----GCTETEQGGKQEQLS-LSMEEILHEC 1037 + + + +G N DL+ L+LE E + EQ++ L + + + Sbjct: 236 PFFDNLTKTIIEQRGGKPTNRKDLMDLILELRQKKAIEPMKKTHDEQVTTLELTDSVIAA 295 Query: 1038 KTFFF--AGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGK--GDPSGDNLGKLKEM 1205 +TF F AGYET++ +++ +F L+ P+ QE++ AEV + + G+ + D L ++ + Sbjct: 296 QTFIFYAAGYETSASTMSFLLFELAENPDIQEKVIAEVDETLKRHNGEITYDTLSEMTYL 355 Query: 1206 TMVLHETLRLYGPALFMQRKTTTDMVVGA--ITIPKEHAIVIGAPFMHRDKKVWGEDADQ 1379 T V HETLR Y A + R D V +T+ K +V+ +H D K + D ++ Sbjct: 356 TQVFHETLRKYPVADILLRNAKADYAVPGTNVTLKKGQTVVVSGFGIHYDPKYY-PDPEK 414 Query: 1380 FNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSF 1538 F+P RF+ R + P A + F G R C+G F + + + +L KF F Sbjct: 415 FDPERFSPENVR-NRHPCAYIPFGAGQRKCLGMRFGQWQVQVCIIKLLSKFRF 466
>O44221:CP4E5_DROMT Cytochrome P450 4e5, mitochondrial precursor - Drosophila mettleri| (Fruit fly) Length = 522 Score = 91.3 bits (225), Expect = 1e-17 Identities = 95/417 (22%), Positives = 171/417 (41%), Gaps = 17/417 (4%) Frame = +3 Query: 333 WRAQYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHFPKNDAHPNXXXXXXXXXXXXXX 512 W + F W G I V + + + I++S + K D + Sbjct: 62 WHKYNKDNFRIWIGYYANILVSNPKHLEVIMNSTT-LIEKLDIYDMLHPWLGEGLLTSKG 120 Query: 513 XDWVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQEL 692 W +HR++I P F + ++ + M F ++ + + + ++F L Sbjct: 121 SKWHKHRKMITPTFHFNILQDFHQVM----NENSAKFIKRLKEVSAGDNIIDFQDETHYL 176 Query: 693 TADIISHTAFGSSYKL-----GMEAFYAQKEL-QAIAISSLLNVQIPGFSYLPTKRNRRK 854 T D I TA G + ++ A K++ I + + +Q F Y R + Sbjct: 177 TLDAICDTAMGVTINAIEKRDTVDVVKAFKDMCHIINMRAFRPLQRSDFLY----RFSPE 232 Query: 855 WMLEKKLRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGGKQEQL--------SL 1010 + K TL N +A + + EG + + + L L Sbjct: 233 YATYAKTLKTLKDFTNDIIAKRIKVHRTAAAKTNQEGSEFSRKKMLPDTLLSATIDGRPL 292 Query: 1011 SMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGKG---DPSGD 1181 + +EI E TF F G++TT+ + + ++LS +PE Q +L E +G D + Sbjct: 293 NQQEIYEEVSTFMFEGHDTTTSGVAFAGYILSRFPEEQRKLYEEQQAVMGNELNRDATFQ 352 Query: 1182 NLGKLKEMTMVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVW 1361 + +K + + + E R+Y F+ R T D + +PK + +G + D +V+ Sbjct: 353 EISAMKYLDLFIKEAQRVYPSVPFIGRYTDKDYNIHGTIMPKGTTLNLGIIVLGYDDRVF 412 Query: 1362 GEDADQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKF 1532 E+ +F P RF + P + FS GPR CIGQ FA+LE K+V++ +++ F Sbjct: 413 -EEPHRFYPERFE----KQKPGPFEYVPFSAGPRNCIGQKFALLELKTVISKLVRTF 464
>Q9V674:CP6G1_DROME Cytochrome P450 6g1 - Drosophila melanogaster (Fruit fly)| Length = 524 Score = 90.9 bits (224), Expect = 2e-17 Identities = 94/417 (22%), Positives = 169/417 (40%), Gaps = 31/417 (7%) Frame = +3 Query: 378 KPRICVFDYELVRQILSSKSGHFPKNDAH--PNXXXXXXXXXXXXXXXDWVRHRRVIDPA 551 KP + + D EL++ IL F A P+ W R + P Sbjct: 81 KPGLIIRDIELIKSILIKDFNRFHNRYARCDPHGDPLGYNNLFFVRDAHWKGIRTKLTPV 140 Query: 552 FAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQELTADIISHTAFG-- 725 F K+K M M + + + KN+ I E + + + D I+ AFG Sbjct: 141 FTSGKVKQMYTLMQEIGKDLELALQRRGEKNSGSFI-TEIKEICAQFSTDSIATIAFGIR 199 Query: 726 -----------SSYKLGMEAFYAQKELQAIA------ISSLLNVQIPGFSYLPTKRNRRK 854 +Y M F + + SL+ +Q + R+ Sbjct: 200 ANSLENPNAEFRNYGRKMFTFTVARAKDFFVAFFLPKLVSLMRIQFFTADFSHFMRSTIG 259 Query: 855 WMLEKKLRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGGKQEQLSLSMEEILHE 1034 ++E++ RS L+R NDL+ +++ E + + + + ++ + Sbjct: 260 HVMEERERSGLLR--------------NDLIDVLVSLRKEAAAEPSKPHYAKNQDFLVAQ 305 Query: 1035 CKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREV--GKGDPSGDNLGKLKEMT 1208 FF AG+ET+S +++ ++ ++ +PE Q+RLR E+ + G G S + + L+ + Sbjct: 306 AGVFFTAGFETSSSTMSFALYEMAKHPEMQKRLRDEINEALVEGGGSLSYEKIQSLEYLA 365 Query: 1209 MVLHETLRLYGPALFMQRKTTT-----DMVVGAI---TIPKEHAIVIGAPFMHRDKKVWG 1364 MV+ E LR+Y F+ R+ + D+ + T+ + I +H D K W Sbjct: 366 MVVDEVLRMYPVLPFLDREYESVEGQPDLSLKPFYDYTLENGTPVFIPIYALHHDPKYW- 424 Query: 1365 EDADQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFS 1535 + QF+P RF + R V A F GP CIG +L++K + ++L+ S Sbjct: 425 TNPSQFDPERF-SPANRKNIVAMAYQPFGSGPHNCIGSRIGLLQSKLGLVSLLKNHS 480
>Q27902:CP6B4_PAPGL Cytochrome P450 6B4 - Papilio glaucus (Tiger swallowtail butterfly)| Length = 500 Score = 90.9 bits (224), Expect = 2e-17 Identities = 90/353 (25%), Positives = 157/353 (44%), Gaps = 13/353 (3%) Frame = +3 Query: 519 WVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQELTA 698 W R+ P F K+K M M F + K +KE + + V++ T Sbjct: 123 WRVLRQCFTPLFTSGKLKNMLNLMSDRGDK----FIKMVEKFCDKEPEQQIIPLVRKFTM 178 Query: 699 DIISHTAFGSSYKLGMEAFYAQKELQAIAISSLLNVQIPGFSYLPTKRNRRKWMLEKKLR 878 I+ AFG +L E +L ++ ++ +I Y + + K + Sbjct: 179 ASITTCAFGM--ELDEEMIETLDKLDSLIFTTSYGNEID-MMYPGILKKLNSSIFSKMIA 235 Query: 879 STLMRIINSRLASQGSGYGN--DLLGLMLE----GCTETEQGGKQEQLS-LSMEEILHEC 1037 + + + +G N DL+ L+LE E + EQ++ L + + + Sbjct: 236 PFFDNLTKTIIEQRGGKPTNRKDLMDLILELRQKKAIEPMKKTHDEQVTTLELTDSVIAA 295 Query: 1038 KTFFF--AGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGK--GDPSGDNLGKLKEM 1205 +TF F AGYET++ +++ +F L+ P+ QE++ AEV + + G+ + D L ++ + Sbjct: 296 QTFIFYAAGYETSASTMSFLLFELAENPDIQEKVIAEVDETLKRHNGEITYDTLSEMTYL 355 Query: 1206 TMVLHETLRLYGPALFMQRKTTTDMVVGA--ITIPKEHAIVIGAPFMHRDKKVWGEDADQ 1379 T V HETLR Y A + R D V +T+ K +V+ +H D K + D ++ Sbjct: 356 TQVFHETLRKYPVADILLRNAKADYAVPGTNVTLKKGQTVVVSGFGIHYDPKYY-PDPEK 414 Query: 1380 FNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSF 1538 F+P RF+ R + P A + F G R C+G F + + + +L KF F Sbjct: 415 FDPERFSPENVR-NRHPCAYIPFGAGQRKCLGMRFGQWQVQVCIIKLLSKFRF 466
>Q92116:CP1A1_STECH Cytochrome P450 1A1 - Stenotomus chrysops (Scup)| Length = 521 Score = 90.9 bits (224), Expect = 2e-17 Identities = 112/471 (23%), Positives = 183/471 (38%), Gaps = 23/471 (4%) Frame = +3 Query: 276 VLHVRDHDYLHRVAPHFLKWRAQYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHF--- 446 VL V + YL A +YG+ F G +P + + E VRQ L + F Sbjct: 57 VLEVGRNPYLSLTA-----MSKRYGDVFQIQIGMRPVVVLSGSETVRQALIKQGDXFAGR 111 Query: 447 PKNDAHPNXXXXXXXXXXXXXXXDWVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFE 626 P + W R++ A T SCA E Sbjct: 112 PDLYSFRFINDGKSLAFSTDQAGVWRARRKLAYSALRSFATLEGTTPEYSCA------LE 165 Query: 627 EQASK---------NTNKEIQVEFD--KSVQELTADIISHTAFGSSYKLGMEAFYAQKEL 773 E SK +T E FD + + A++I FG Y + L Sbjct: 166 EHVSKEAEYLVKQLHTVMEADGSFDPFRHIVVSVANVICGMCFGRRYDHNHQELLNLVNL 225 Query: 774 -----QAIAISSLLNVQIPGFSYLPTKRNRRKWMLEKKLRSTLMRIINSRLASQGSGYGN 938 Q +A + + IP YLP+ ++ + + + + +I++ + Sbjct: 226 SDEFGQVVASGNPADF-IPILQYLPSTTMKKFLNINDRFNTFVQKIVSEHYTTFDKDNIR 284 Query: 939 DLLGLMLEGCTETEQGGKQEQLSLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPE 1118 D+ +++ C E + + + +S E+I+ F AG++T S L+W+V L YPE Sbjct: 285 DITDSLIDHC-EDRKLDENSNVQMSDEKIVGIVNDLFGAGFDTISTALSWSVMYLVAYPE 343 Query: 1119 WQERLRAEVLREVGKG-DPSGDNLGKLKEMTMVLHETLRLYGPALF-MQRKTTTDMVVGA 1292 QERL E+ VG P + KL + + ET R F + T+ D + Sbjct: 344 IQERLYQEMNETVGPDRTPCLSDKPKLPFLEAFILETFRHSSFLPFTIPHCTSKDTSLNG 403 Query: 1293 ITIPKEHAIVIGAPFMHRDKKVWGEDADQFNPMRF--ANGVARAAKVPHALLAFSIGPRA 1466 IPK+ + I ++ D ++W +D FNP RF A+G ++ F +G R Sbjct: 404 YFIPKDTCVFINQWQINHDAELW-KDPSSFNPDRFLNADGTEVNKLEGEKMMVFGMGKRR 462 Query: 1467 CIGQNFAMLEAKSVMATVLQKFSFALSPSYVHAPADFLTLRPKFGLPVVMK 1619 CIG+ A E +A ++Q F P + L + P++GL + K Sbjct: 463 CIGEVIARSEVFLFLAILVQNLRFH------SMPGEPLDMTPEYGLTMKHK 507
>O42457:CP1A1_SPAAU Cytochrome P450 1A1 - Sparus aurata (Gilthead sea bream)| Length = 521 Score = 90.9 bits (224), Expect = 2e-17 Identities = 112/472 (23%), Positives = 183/472 (38%), Gaps = 24/472 (5%) Frame = +3 Query: 276 VLHVRDHDYLHRVAPHFLKWRAQYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHF--- 446 VL V + YL A +YG+ F G +P + + E VRQ L + F Sbjct: 57 VLEVGRNPYLSLTA-----MSKRYGDVFQIQIGMRPVVVLSGSETVRQALIKQGDDFAGR 111 Query: 447 PKNDAHPNXXXXXXXXXXXXXXXDWVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFE 626 P + W R++ A T SCA E Sbjct: 112 PDLYSFRFINDGKSLAFSTDQAGVWRARRKLAYSALRSFSTLEGTTPEYSCA------LE 165 Query: 627 EQASK---------NTNKEIQVEFD--KSVQELTADIISHTAFGSSYKLGMEAFYAQKEL 773 E SK NT E FD + + A++I FG Y + L Sbjct: 166 EHVSKEAEYLVKQLNTVMETDGSFDPFRHIVVSVANVICGMCFGRRYDHNNQELLNLVNL 225 Query: 774 -----QAIAISSLLNVQIPGFSYLPTKRNRRKWMLEKKLRSTLMRIINSRLASQGSGYGN 938 Q +A + + IP YLP+ ++ + + + + +I++ + Sbjct: 226 SDEFGQVVASGNPADF-IPILQYLPSTSMKKFVSINDRFNAFVQKIVSEHYTTFDKDNIR 284 Query: 939 DLLGLMLEGCTETEQGGKQEQLSLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPE 1118 D+ +++ C E + + + +S E+++ F AG++T S L+W+V L YPE Sbjct: 285 DITDSLIDHC-EDRKLDENSNVQMSDEKVVGIVNDLFGAGFDTISTALSWSVMYLVAYPE 343 Query: 1119 WQERLRAEVLREVG-KGDPSGDNLGKLKEMTMVLHETLRLYGPALF-MQRKTTTDMVVGA 1292 QERL E+ VG P + KL + + E R F + ++ D + Sbjct: 344 IQERLYQEMKESVGLDRTPCLSDKPKLPFLEAFILEIFRHSSFLPFTIPHCSSKDTSLNG 403 Query: 1293 ITIPKEHAIVIGAPFMHRDKKVWGEDADQFNPMRFAN--GVARAAKVPHALLAFSIGPRA 1466 IPK+ + I ++ D ++W +D FNP RF N G ++ F +G R Sbjct: 404 YFIPKDTCVFINQWQINHDPELW-KDPSSFNPDRFLNTDGTELNKLEGEKMMVFGLGKRR 462 Query: 1467 CIGQNFAMLEAKSVMATVLQKFSFALSPSYVHA-PADFLTLRPKFGLPVVMK 1619 CIG+ A E +A ++Q F HA P + L + P++GL + K Sbjct: 463 CIGEVIARNEVFLFLAILVQNLRF-------HAKPGEPLDMTPEYGLTMKHK 507
>Q64410:CP17A_CAVPO Cytochrome P450 17A1 - Cavia porcellus (Guinea pig)| Length = 508 Score = 90.9 bits (224), Expect = 2e-17 Identities = 92/417 (22%), Positives = 175/417 (41%), Gaps = 13/417 (3%) Frame = +3 Query: 321 HFLKWRAQYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHF---PKNDAHPNXXXXXXX 491 +F K + +YG + F G+ + + ++L R++L K F P Sbjct: 52 NFFKLQKKYGPIYSFRLGSTTTVVIGHHQLARELLIKKGKEFSGRPLTTTVALLSDNGKG 111 Query: 492 XXXXXXXXDWVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEF 671 W HRR++ +F++ + + C Q + + A+ + + + Sbjct: 112 IAFADSSATWQLHRRLVLSSFSLFRDGEQKLENIIC-QELSALCDFLATCDGQVK---DL 167 Query: 672 DKSVQELTADIISHTAFGSSYKLGMEAFYAQKELQAIAISSLLNVQIPG-FSYLPTKRNR 848 S+ +II F SYK G + ++SL + + F +L N+ Sbjct: 168 SSSIFMTVVNIICMICFSVSYKEGDMELVTIRRFTTGFVNSLSDDNLVDIFPWLKIFPNK 227 Query: 849 RKWMLEK--KLRSTLM-RIINSRLASQGSGYGNDLLGLMLEGCTETEQGGK---QEQLSL 1010 M+ K ++R ++ +I+ S ++L+ L+++ Q+ Sbjct: 228 TLEMIRKYTEIRGAMLSKILKECKEKFRSDSVSNLIDLLIQAKVNENNNNSSLDQDSNLF 287 Query: 1011 SMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVG-KGDPSGDNL 1187 S + IL F AG ET+S ++ W + L P+ +++++ E+ VG P+ + Sbjct: 288 SDKHILTTLGDIFGAGVETSSSVVLWVIAFLLHNPQVKKKIQEEIDHNVGFSRTPTFSDR 347 Query: 1188 GKLKEMTMVLHETLRLYGPA-LFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWG 1364 L + + E LR+ A + + K TD +G I K+ +++ +H +++ W Sbjct: 348 NHLLMLEATIREVLRIRPVAPILIPHKANTDSSIGEFAIDKDTNVLVNLWALHHNEQEW- 406 Query: 1365 EDADQFNPMRFANGVARAAKVPHA-LLAFSIGPRACIGQNFAMLEAKSVMATVLQKF 1532 + DQF P RF + VP + L F GPR+C+G+ A E + A +LQKF Sbjct: 407 DRPDQFMPERFLDPTGSQIIVPSSSYLPFGAGPRSCVGEALARQEIFLITAWLLQKF 463
>Q9V4I1:CP9B2_DROME Cytochrome P450 9b2 - Drosophila melanogaster (Fruit fly)| Length = 505 Score = 90.5 bits (223), Expect = 2e-17 Identities = 100/417 (23%), Positives = 175/417 (41%), Gaps = 27/417 (6%) Frame = +3 Query: 381 PRICVFDYELVRQILSSKSGHFPKNDAH-PNXXXXXXXXXXXXXXXDWVRHRRVIDPAFA 557 P I + D EL++++ HFP + + W R + P F Sbjct: 80 PMITLNDPELIKKVCVKDFDHFPNHQPFITSNDRLFNDMLSVMRDQRWKHMRNTLTPVFT 139 Query: 558 MDKIK----AMTKTMVSCAQSTFGVFEEQASKNT--NKEIQVEFDKSVQELTADIISHTA 719 K++ M ++ C Q + +SK K +V+ +L+ DII+ TA Sbjct: 140 AAKMRNMFTLMNESFAECLQHL-----DSSSKTLPGRKGFEVDMKVMCNKLSNDIIATTA 194 Query: 720 FG---SSYKLGMEAFYAQKELQAIAISSLLNVQIPGFSYLPTKRNRRKWMLEKKLRSTLM 890 FG +SY FY I S + + + F ++ + + + L K Sbjct: 195 FGLKVNSYDNPKNEFYE------IGQSLVFSRGLQFFKFMLSTLVPKLFSLLKLTIFDSA 248 Query: 891 RI-INSRLASQGSGYGN-------DLLGLMLEGCTETEQGGKQEQLSLSMEEILHECKTF 1046 ++ +RL + Y D++ L++E E+E + +EI+ +C F Sbjct: 249 KVDYFARLVVEAMQYREKHNITRPDMIQLLMEAKNESED-------KWTDDEIVAQCFIF 301 Query: 1047 FFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVL--REVGKGDP-SGDNLGKLKEMTMVL 1217 FFA +E S L+ T + L P+ QERL E++ ++ G P + D + K+ M MV+ Sbjct: 302 FFAAFENNSNLICTTTYELLYNPDVQERLYEEIVETKKALNGAPLTYDAVQKMTYMDMVI 361 Query: 1218 HETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPF------MHRDKKVWGEDADQ 1379 E+LR + A R + D + K +G +H D + + E + Sbjct: 362 SESLRKWTLAAATDRLCSKDYTLTDDDGTKLFDFKVGDRINIPISGLHLDDRYFPEPR-K 420 Query: 1380 FNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSP 1550 F+P RF+ + VP+ L F +GPR CIG +A+++ K ++ +L + SP Sbjct: 421 FDPDRFSEE-RKGDMVPYTYLPFGVGPRNCIGNRYALMQVKGMLFNLLLHYKIEASP 476
>Q9VFP1:CP6D5_DROME Probable cytochrome P450 6d5 - Drosophila melanogaster (Fruit fly)| Length = 508 Score = 90.5 bits (223), Expect = 2e-17 Identities = 104/399 (26%), Positives = 166/399 (41%), Gaps = 31/399 (7%) Frame = +3 Query: 519 WVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQELTA 698 W R + P+F K+KAM +T S +Q N KE++++ K + Sbjct: 123 WRALRNKLTPSFTSGKLKAMFETSDSVGDKLVDSIRKQLPANGAKELELK--KLMATYAI 180 Query: 699 DIISHTAFGSSYKLGMEAFY-AQKELQAIA-----------ISSLLNVQIPGFSYLPTKR 842 DII+ T FG L +++F E Q I+ I + PG K Sbjct: 181 DIIATTIFG----LDVDSFADPNNEFQIISKKVNRNNIEDIIRGTSSFLYPGLEKFFVKI 236 Query: 843 NRRKWMLEKKLRSTLMRIINSR---LASQGSGYGNDLLGLMLE----GCTETE------Q 983 ++ E+ MR +++R L Q + DLL L+L+ G T+ + Sbjct: 237 GWKQEATER------MRELSNRTVDLREQNNIVRKDLLQLLLQLRNQGKINTDDNIWSAE 290 Query: 984 GGKQEQLSLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGK 1163 K S+S + I + F+ AGYETT+ ++T++ L+ PE E+ + +V + K Sbjct: 291 STKNGVKSMSKDLIAGQLFLFYVAGYETTASTTSFTLYELTQNPEVMEKAKEDVRSAIEK 350 Query: 1164 --GDPSGDNLGKLKEMTMVLHETLRLYGPALFMQRKTTTDMVV--GAITIPKEHAIVIGA 1331 G + D + +K + + ET R Y + R T D V + I K I+I Sbjct: 351 HGGKLTYDAISDMKYLEACILETARKYPALPLLNRICTKDYPVPDSKLVIQKGTPIIISL 410 Query: 1332 PFMHRDKKVWGEDADQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVM 1511 MHRD++ + D + P R+ + A L F GPR CIG + K + Sbjct: 411 IGMHRDEEYF-PDPLAYKPERYLENGKDYTQA--AYLPFGEGPRMCIGARMGKVNVKIAI 467 Query: 1512 ATVLQKFSFAL--SPSYVHAPADFLTLRPKFGLPVVMKL 1622 A VL F + + + L PK G+PV + L Sbjct: 468 AKVLSNFDLEIRKEKCEIEFGVYGIPLMPKSGVPVRLSL 506
>Q9GMC7:CP17A_BISBI Cytochrome P450 17A1 - Bison bison (American bison)| Length = 509 Score = 90.5 bits (223), Expect = 2e-17 Identities = 95/422 (22%), Positives = 175/422 (41%), Gaps = 14/422 (3%) Frame = +3 Query: 321 HFLKWRAQYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHF---PKNDAHPNXXXXXXX 491 +F K + +YG + F G+K + + ++L R++L K F PK Sbjct: 52 NFFKLQEKYGPIYSFRLGSKTTVMIGHHQLAREVLLKKGKEFSGRPKVATLDILSDNQKG 111 Query: 492 XXXXXXXXDWVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEF 671 W HR++ AFA+ K K Q + + A+++ ++ Sbjct: 112 IAFADHGAHWQLHRKLALNAFALFK-DGNLKLEKIINQEANVLCDFLATQHGEA---IDL 167 Query: 672 DKSVQELTADIISHTAFGSSYKLGMEAFYAQKE-----LQAIAISSLLNVQIPGFSYLPT 836 + + +IIS F S+K A A + L+ ++ LL++ P P+ Sbjct: 168 SEPLSLAVTNIISFICFNFSFKNEDPALKAIQNVNDGILEVLSKEVLLDI-FPVLKIFPS 226 Query: 837 KRNRRKWMLEKKLRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQ---GGKQEQLS 1007 K + + L I+ + S +LL ++++ + G Q+ Sbjct: 227 KAMEKMKGYVQTRNELLNEILEKCQENFSSDSITNLLHILIQAKVNADNNNAGPDQDSKL 286 Query: 1008 LSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVG-KGDPSGDN 1184 LS +L F AG ETT+ ++ W V L +P ++R++ ++ + +G P+ + Sbjct: 287 LSSRHMLATIGDIFGAGVETTTSVIKWIVAYLLHHPSLKKRIQDDIDQIIGFNRTPAISD 346 Query: 1185 LGKLKEMTMVLHETLRLYGPA-LFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVW 1361 +L + + E LR+ A + K D +G +TI K +V+ +H +K W Sbjct: 347 RNRLVLLEATIREVLRIRPVAPTLIPHKAVIDSSIGDLTIDKGTDVVVNLWALHHSEKEW 406 Query: 1362 GEDADQFNPMRFANGVARAAKVPH-ALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSF 1538 + D F P RF + P + L F GPR+C+G+ A E M+ +LQ+F+ Sbjct: 407 -QHPDLFMPERFLDPTGTQLISPSLSYLPFGAGPRSCVGEMLARQELFLFMSRLLQRFNL 465 Query: 1539 AL 1544 + Sbjct: 466 EI 467
>P05185:CP17A_BOVIN Cytochrome P450 17A1 - Bos taurus (Bovine)| Length = 509 Score = 90.1 bits (222), Expect = 3e-17 Identities = 95/422 (22%), Positives = 175/422 (41%), Gaps = 14/422 (3%) Frame = +3 Query: 321 HFLKWRAQYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHF---PKNDAHPNXXXXXXX 491 +F K + +YG + F G+K + + ++L R++L K F PK Sbjct: 52 NFFKLQEKYGPIYSFRLGSKTTVMIGHHQLAREVLLKKGKEFSGRPKVATLDILSDNQKG 111 Query: 492 XXXXXXXXDWVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEF 671 W HR++ AFA+ K K Q + + A+++ ++ Sbjct: 112 IAFADHGAHWQLHRKLALNAFALFK-DGNLKLEKIINQEANVLCDFLATQHGEA---IDL 167 Query: 672 DKSVQELTADIISHTAFGSSYKLGMEAFYAQKE-----LQAIAISSLLNVQIPGFSYLPT 836 + + +IIS F S+K A A + L+ ++ LL++ P P+ Sbjct: 168 SEPLSLAVTNIISFICFNFSFKNEDPALKAIQNVNDGILEVLSKEVLLDI-FPVLKIFPS 226 Query: 837 KRNRRKWMLEKKLRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQ---GGKQEQLS 1007 K + + L I+ + S +LL ++++ + G Q+ Sbjct: 227 KAMEKMKGCVQTRNELLNEILEKCQENFSSDSITNLLHILIQAKVNADNNNAGPDQDSKL 286 Query: 1008 LSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVG-KGDPSGDN 1184 LS +L F AG ETT+ ++ W V L +P ++R++ ++ + +G P+ + Sbjct: 287 LSNRHMLATIGDIFGAGVETTTSVIKWIVAYLLHHPSLKKRIQDDIDQIIGFNRTPTISD 346 Query: 1185 LGKLKEMTMVLHETLRLYGPA-LFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVW 1361 +L + + E LR+ A + K D +G +TI K +V+ +H +K W Sbjct: 347 RNRLVLLEATIREVLRIRPVAPTLIPHKAVIDSSIGDLTIDKGTDVVVNLWALHHSEKEW 406 Query: 1362 GEDADQFNPMRFANGVARAAKVPH-ALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSF 1538 + D F P RF + P + L F GPR+C+G+ A E M+ +LQ+F+ Sbjct: 407 -QHPDLFMPERFLDPTGTQLISPSLSYLPFGAGPRSCVGEMLARQELFLFMSRLLQRFNL 465 Query: 1539 AL 1544 + Sbjct: 466 EI 467
>Q6JZS3:CP1A1_ORYLA Cytochrome P450 1A1 - Oryzias latipes (Medaka fish) (Japanese| ricefish) Length = 521 Score = 89.7 bits (221), Expect = 4e-17 Identities = 70/278 (25%), Positives = 125/278 (44%), Gaps = 4/278 (1%) Frame = +3 Query: 810 IPGFSYLPTKRNRRKWMLEKKLRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGG 989 IP YLP+K ++ + + +S + +I+N A+ D+ +++ C E + Sbjct: 242 IPALRYLPSKAMKKFVEINNRFQSFVQKIVNEHSATYDKDNIRDITDSLIDHC-EDRKLD 300 Query: 990 KQEQLSLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVG-KG 1166 + + +S E+++ F AG++T S L+W V L YP+ ++ L E+ +G Sbjct: 301 ENSNIQMSDEKVVGIVNDLFGAGFDTISTALSWAVGYLVAYPDIEKGLFEEIKENIGLNR 360 Query: 1167 DPSGDNLGKLKEMTMVLHETLRLYGPALF-MQRKTTTDMVVGAITIPKEHAIVIGAPFMH 1343 +P+ + L + E R F + TT D + IPK+ + I ++ Sbjct: 361 NPTISDRSNLPLTDAFILEIFRHSSFLPFTIPHCTTRDTSLNGYYIPKDTCVFINQWQIN 420 Query: 1344 RDKKVWGEDADQFNPMRF--ANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMAT 1517 D K+W +D FNP RF +G ++ F +G R CIG+ A E +A Sbjct: 421 HDPKLW-QDPSSFNPDRFLSEDGSEVNRLDGEKVMVFGLGKRRCIGEVIARNEVFLFLAI 479 Query: 1518 VLQKFSFALSPSYVHAPADFLTLRPKFGLPVVMKLLDV 1631 ++QK F P + L + P++GL + K +V Sbjct: 480 MIQKLCFE------EMPGEPLDMTPEYGLTMKHKRCNV 511
>Q9LTM1:C71BM_ARATH Cytochrome P450 71B22 - Arabidopsis thaliana (Mouse-ear cress)| Length = 500 Score = 89.7 bits (221), Expect = 4e-17 Identities = 97/435 (22%), Positives = 178/435 (40%), Gaps = 21/435 (4%) Frame = +3 Query: 303 LHRVAPHFLKWRAQYGEPFLFWFGAKPRICVFDYELVRQILSS---KSGHFPKNDAHPNX 473 LHR F K YG FG P + V E ++L + ++ PK A Sbjct: 48 LHR---SFHKLSQNYGPVMFLHFGVVPVVVVSTREAAEEVLKTHDLETCTRPKLTATKLF 104 Query: 474 XXXXXXXXXXXXXXDWVRHRRV-IDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTN 650 DW R++ + F+ K+KA ++ V + SK+ Sbjct: 105 SYNYKDIGFAQYGDDWREMRKLAMLELFSSKKLKAFRYIREEESE----VLVNKLSKSAE 160 Query: 651 KEIQVEFDKSVQELTADIISHTAFGSSYKLGMEAFYAQKELQAIAISSLLNVQIPGFS-Y 827 V+ K++ TA I+ AFG ++ F +++ + + S N+ F+ + Sbjct: 161 TRTMVDLRKALFSYTASIVCRLAFGQNFHEC--DFVDMDKVEDLVLESETNLGSFAFTDF 218 Query: 828 LPTKRNRRKWMLEK-------------KLRSTLMRIINSRLASQGSGYGNDLLGLMLEGC 968 P W++++ +L + +I+ L S +D++G+ML+ Sbjct: 219 FPAGLG---WVIDRISGQHSELHKAFARLSNFFQHVIDDHLKPGQSQDHSDIIGVMLDMI 275 Query: 969 TETEQGGKQEQLSLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVL 1148 + + G ++ + + F AG ++ + W + L+ +P ++L+ E+ Sbjct: 276 NKESKVGS---FQVTYDHLKGVMSDVFLAGVNAGAITMIWAMTELARHPRVMKKLQQEIR 332 Query: 1149 REVG--KGDPSGDNLGKLKEMTMVLHETLRLYGPA-LFMQRKTTTDMVVGAITIPKEHAI 1319 +G K + +L K+ + +V+ ET RL+ PA L + R+T +D+ + IPK I Sbjct: 333 EILGDNKEKITEQDLEKVHYLKLVIEETFRLHPPAPLLLPRETMSDLKIQGYNIPKNTMI 392 Query: 1320 VIGAPFMHRDKKVWGEDADQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEA 1499 I + RD W E+ + FNP RF + + LL F G R C G + Sbjct: 393 EINTYSIGRDPNCW-ENPNDFNPERFIDSPVEYKGQHYELLPFGAGRRICPGMATGITIV 451 Query: 1500 KSVMATVLQKFSFAL 1544 + + VL F ++L Sbjct: 452 ELGLLNVLYFFDWSL 466
>Q42716:C71A8_MENPI Cytochrome P450 71A8 - Mentha piperita (Peppermint)| Length = 502 Score = 89.7 bits (221), Expect = 4e-17 Identities = 77/294 (26%), Positives = 135/294 (45%), Gaps = 8/294 (2%) Frame = +3 Query: 687 ELTADIISHTAFGSSYKLGMEAFYAQKELQAIAISSLLNVQIPGF--SYLPTKR----NR 848 +LT D++ +A G Y G E E+ + L + I F S R +R Sbjct: 185 QLTNDVVCRSAIGRKYGAGDENGEKFLEILREFLELLGAISIGDFVPSLWWINRINGFDR 244 Query: 849 RKWMLEKKLRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGGKQEQLSLSMEEIL 1028 R + K++ L ++I+ RL + + + + ++LE G +S+ + I Sbjct: 245 RVDRIAKEMDEFLEKVIHERLENPAAKAEENFVDILLEIYRNNSAG-----VSIDRDSIK 299 Query: 1029 HECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREV-GKGDPSGDNLGKLKEM 1205 F AG +TT+++L W + L +PE ++L++EV + V K + + D++ K+ + Sbjct: 300 AIILDVFAAGTDTTAVVLEWAMTELLRHPEIMKKLQSEVRQVVKDKHNITDDDIEKMHYL 359 Query: 1206 TMVLHETLRLYGPA-LFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDADQF 1382 V+ ET+R + P L + R D+ V +P ++I A + RD W E ++F Sbjct: 360 KAVMKETMRFHTPIPLLVPRVARNDVEVMGYDVPVGTMVMINAWAIGRDPTSWDEP-EKF 418 Query: 1383 NPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFAL 1544 P RF N + L+ F G R C G F M + +A ++QKF + L Sbjct: 419 RPERFLNSSVDFKGLDFELIPFGAGRRGCPGTTFPMATLEFTLANLMQKFDWEL 472
>Q9V4T3:C4AD1_DROME Probable cytochrome P450 4ad1 - Drosophila melanogaster (Fruit fly)| Length = 516 Score = 89.7 bits (221), Expect = 4e-17 Identities = 89/359 (24%), Positives = 157/359 (43%), Gaps = 21/359 (5%) Frame = +3 Query: 519 WVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQELTA 698 W++H+++ PAF I+ + + T G F ++ ++ + + + V + T Sbjct: 126 WLKHQKLYAPAFERSAIEGYLRVV----HRTGGQFVQKLDVLSDTQEVFDAQELVAKCTL 181 Query: 699 DIISHTAFGS-SYKLGMEAFYAQKELQAIAISSLLNV-QIPGFSYLPTK----RNRRKWM 860 DI+ A G S L E +L AI L +V Q FS + R +M Sbjct: 182 DIVCENATGQDSSSLNGET----SDLHG-AIKDLCDVVQERTFSIVKRFDALFRLTSYYM 236 Query: 861 LEKK----LRSTLMRIINSR--------LASQGSGYGNDLLGLMLEGCTETEQGGKQEQL 1004 +++ LRS L RII+ R QG L ++L K + Sbjct: 237 KQRRALSLLRSELNRIISQRRHQLAAENTCQQGQPINKPFLDVLLTA--------KLDGK 288 Query: 1005 SLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGKGDPSGDN 1184 L EI+ E TF F G++ + +++T++ LS + E Q++ E R G+ + Sbjct: 289 VLKEREIIEEVSTFIFTGHDPIAAAISFTLYTLSRHSEIQQKAAEEQRRIFGENFAGEAD 348 Query: 1185 LGKLKEM---TMVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKK 1355 L +L +M +++ ETLRLY + R + + + K +++ M ++K Sbjct: 349 LARLDQMHYLELIIRETLRLYPSVPLIARTNRNPIDINGTKVAKCTTVIMCLIAMGYNEK 408 Query: 1356 VWGEDADQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKF 1532 + +D F P RF N + FS GPR CI + FAM + K++++ +L++F Sbjct: 409 YF-DDPCTFRPERFENPTGNVGIEAFKSVPFSAGPRRCIAEKFAMYQMKALLSQLLRRF 466
>O57525:CP17A_RANDY Cytochrome P450 17A1 - Rana dybowskii (Dybovsky's frog) (Korean brown| frog) Length = 519 Score = 89.4 bits (220), Expect = 5e-17 Identities = 108/459 (23%), Positives = 190/459 (41%), Gaps = 22/459 (4%) Frame = +3 Query: 309 RVAPH--FLKWRAQYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHF---PKNDAHPNX 473 ++ PH F + +YG + F G+ + V ++E R++L K F P+ Sbjct: 60 KLPPHILFCNLQKKYGSLYSFMMGSHYVVVVNNHEDAREVLLKKGKTFGGRPRTVTTDIL 119 Query: 474 XXXXXXXXXXXXXXDWVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASK---- 641 W HR+++ A M + V+ Q + E AS Sbjct: 120 TRDGKDIAFADYSPTWKFHRKMVHSALCM-----FGEGTVAIEQI---ISREAASLCQTL 171 Query: 642 NTNKEIQVEFDKSVQELTADIISHTAFGSSYKLGMEAF-----YAQKELQAIAISSLLNV 806 + + I ++ + +++ F + YK G F Y++ + +A SL+++ Sbjct: 172 TSFQRIPLDMAPELIRAVTNVVCSLCFNTRYKRGDAEFETMLKYSKGIVDTVAKDSLVDI 231 Query: 807 QIPGFSYLPTKRNRRKWMLEKKLRST---LMRIINSRLASQGSGYGNDLLGLMLEGCTET 977 F +L N+ +L + + + L + IN + DL+ +L+ Sbjct: 232 ----FPWLQIFPNKDLDILRQSVAARDQLLQKKINEHKDAFCGETVKDLVDALLKAKLNM 287 Query: 978 EQGGKQ--EQLSLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLR 1151 E + + L+ + IL F AG ETTS +L W V L YPE Q++++ E+ Sbjct: 288 ENNNSNVSQDVGLTEDHILMTVGDIFGAGVETTSTVLKWAVAYLLHYPEVQKKIQEELDV 347 Query: 1152 EVGKGD-PSGDNLGKLKEMTMVLHETLRLYGPA-LFMQRKTTTDMVVGAITIPKEHAIVI 1325 +VG G P + L + E LR+ + L + + +G TIPKE +VI Sbjct: 348 KVGFGRYPLLSDRKILHYTEAAISEVLRIRPVSPLLIPHVALKESSIGEYTIPKEARVVI 407 Query: 1326 GAPFMHRDKKVWGEDADQFNPMRFANGVARAAKVPH-ALLAFSIGPRACIGQNFAMLEAK 1502 +H D+K W + F+P RF + P + L F G R C+G+ A +E Sbjct: 408 NLWSLHHDEKEW-VNPHLFSPDRFLDENGNRVYSPSPSFLPFGAGIRVCLGEALAKMEVF 466 Query: 1503 SVMATVLQKFSFALSPSYVHAPADFLTLRPKFGLPVVMK 1619 ++ +LQ+F+ + P P L KFG+ + +K Sbjct: 467 LFLSWILQRFTLEV-PEGDPLP----DLEGKFGVVIQVK 500
>Q9STL1:C71AM_ARATH Cytochrome P450 71A22 - Arabidopsis thaliana (Mouse-ear cress)| Length = 490 Score = 89.4 bits (220), Expect = 5e-17 Identities = 93/421 (22%), Positives = 174/421 (41%), Gaps = 15/421 (3%) Frame = +3 Query: 342 QYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHF---PKNDAHPNXXXXXXXXXXXXXX 512 +YG L FG P + V ++ R IL + F P++ Sbjct: 62 RYGPLMLLRFGLVPVLVVSSADVARDILKTYDRVFASRPRSKIFEKIFYEARDVALAPYG 121 Query: 513 XDWVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQEL 692 W + + V +K M ++ + Q + E+ K+++ +QV + + L Sbjct: 122 EYWRQMKSVCVLHLLTNK---MVRSFRNVRQEEISLMMEKIQKSSS--LQVNLSELLGSL 176 Query: 693 TADIISHTAFGSSYKLGMEAFYAQKELQAIAISSLLNVQIPGFSYLPTKRNRRKWM--LE 866 T D+IS A G Y + K L + + +P +++ W+ L+ Sbjct: 177 TNDVISRVALGRKYSDETDFKELMKRLTKLLGEFCVGTYVPWLAWID-------WISGLD 229 Query: 867 KKLRST-------LMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGGKQEQLSLSMEEI 1025 +L+ T L +++ G D + ++L E G + ++LS+ + Sbjct: 230 GQLKKTGNDLDEFLEKVVQDH--EDGDAQRTDFVDVLLRIQREKSVGFEIDRLSIKAIIL 287 Query: 1026 LHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGKGDPS--GDNLGKLK 1199 G +T+ L+ W + L PE RL+ EV R + KG+ S D++ + Sbjct: 288 -----DVVVGGTDTSYALMEWAMTELLHRPECLNRLQEEV-RTICKGNSSVSEDDIKDMN 341 Query: 1200 EMTMVLHETLRLYGPA-LFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDAD 1376 + V+ ET+RL+ P L + ++T D+ +G IP ++I A + R+ WG DA+ Sbjct: 342 YLKAVIKETMRLHPPLPLMVPHESTQDVRLGDYHIPAGTQVMINAWAIGREAATWGPDAE 401 Query: 1377 QFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSPSY 1556 +F P R N L+ F G R C +FA++ + +A ++ ++ + L Y Sbjct: 402 KFRPERHLNSSVDFRGHNFELIPFGAGRRICPAISFAVILIEVTLANLVHRYDWRLPEEY 461 Query: 1557 V 1559 + Sbjct: 462 I 462
>P16496:CP52C_CANMA Cytochrome P450 52A3 - Candida maltosa (Yeast)| Length = 523 Score = 89.0 bits (219), Expect = 6e-17 Identities = 100/419 (23%), Positives = 162/419 (38%), Gaps = 29/419 (6%) Frame = +3 Query: 399 DYELVRQILSSKSGHFPKNDAHPNXXXXXXXXXXXXXXXDWVRHRRVIDPAFAMDKIKAM 578 D E ++ +L+++ F H + W R ++ P FA ++I Sbjct: 105 DPENIKAVLATQFNDFALGARHAHFDPLLGDGIFTLDGEGWKLSRAMLRPQFAREQI--- 161 Query: 579 TKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQELTADIISHTAFGSSYKLGMEAFY 758 V + + +Q N K ++ + T D + FG S + + Y Sbjct: 162 --AHVKALEPHVQILAKQIKLNKGKTFDLQ--ELFFRFTVDTATEFLFGES----VHSLY 213 Query: 759 AQKELQAIAISSLLNVQIPGFSYLPTKRNRRKWMLEKKLRSTLM---------RIINSRL 911 +K + IPG N + L + S + R N+++ Sbjct: 214 DEK------LGIPAPNDIPGRENFAEAFNTSQHYLATRTYSQIFYWLTNPKEFRDCNAKV 267 Query: 912 ASQGSGYGNDLLGLMLEGCTETEQGGKQEQLSLSMEE-----ILHECKTFFFAGYETTSL 1076 + N L + E +GG L + + + AG +TT+ Sbjct: 268 HKLAQYFVNTALNATEKEVEEKSKGGYVFLYELVKQTRDPKVLQDQLLNIMVAGRDTTAG 327 Query: 1077 LLTWTVFLLSVYPEWQERLRAEVLREVGKGDP------SGDNLGKLKEMTMVLHETLRLY 1238 LL++ +F L+ P+ +LR EV G GD S + L K + + VL+ETLR+Y Sbjct: 328 LLSFAMFELARNPKIWNKLREEVEVNFGLGDEARVDEISFETLKKCEYLKAVLNETLRMY 387 Query: 1239 GPALFMQRKTTTDMVV---------GAITIPKEHAIVIGAPFMHRDKKVWGEDADQFNPM 1391 R T D + I +PK ++V HR K+ +GEDA +F P Sbjct: 388 PSVPINFRTATRDTTLPRGGGKDGNSPIFVPKGSSVVYSVYKTHRLKQFYGEDAYEFRPE 447 Query: 1392 RFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSPSYVHAP 1568 R+ R K+ A L F+ GPR C+GQ FA+ EA V+A + Q F S + P Sbjct: 448 RWFEPSTR--KLGWAYLPFNGGPRICLGQQFALTEASYVIARLAQMFEHLESKDETYPP 504
>O42231:CP1A1_LIZAU Cytochrome P450 1A1 - Liza aurata (Golden grey mullet)| Length = 521 Score = 89.0 bits (219), Expect = 6e-17 Identities = 73/274 (26%), Positives = 123/274 (44%), Gaps = 4/274 (1%) Frame = +3 Query: 810 IPGFSYLPTKRNRRKWMLEKKLRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGG 989 IP YLP K ++ + + S + +I++ A+ D+ +++ C E + Sbjct: 242 IPILQYLPNKTMKKFVNINDRFISFVQKIVSEHYATFNKDNIRDITDSLIDHC-EDRKLD 300 Query: 990 KQEQLSLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVG-KG 1166 + + +S E+++ F AG +T S L+W+V L YPE QERL E+ VG Sbjct: 301 ENANVQMSDEKVVGIVNDLFGAGLDTISTALSWSVMYLVAYPEIQERLYQELKENVGLDR 360 Query: 1167 DPSGDNLGKLKEMTMVLHETLRLYGPALF-MQRKTTTDMVVGAITIPKEHAIVIGAPFMH 1343 P + L + + E R F + TT D + IPK+ + I ++ Sbjct: 361 TPVLSDRNNLPLLEAFILEIFRHSSFLPFTIPHCTTKDTSLNGYYIPKDTCVFINQWQIN 420 Query: 1344 RDKKVWGEDADQFNPMRF--ANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMAT 1517 D ++W E + FNP RF A+G ++ F +G R CIG+ A E +A Sbjct: 421 HDPELWKEPS-SFNPDRFLSADGTEVNKVDGEKVMVFGLGKRRCIGEVIARNEVYMFLAI 479 Query: 1518 VLQKFSFALSPSYVHAPADFLTLRPKFGLPVVMK 1619 ++QK F + P + L + P++GL + K Sbjct: 480 LIQKLHF------YNLPGEPLDMTPEYGLTMKHK 507
>P58048:C71B8_ARATH Cytochrome P450 71B8 - Arabidopsis thaliana (Mouse-ear cress)| Length = 506 Score = 89.0 bits (219), Expect = 6e-17 Identities = 92/427 (21%), Positives = 176/427 (41%), Gaps = 20/427 (4%) Frame = +3 Query: 324 FLKWRAQYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHF---PKNDAHPNXXXXXXXX 494 F K ++G L FG P + + E +Q+L S+ PK A+ Sbjct: 54 FHKLSLEHGPVMLLRFGVVPMVVISSKEAAKQVLKSRDLETCSRPKLVANGLFTRNFKDI 113 Query: 495 XXXXXXXDWVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFD 674 DW ++++ K + + + + ++ SK++ + V+ Sbjct: 114 AFAQYGEDWREMKKLVGLELFNPKKHKFFRYI---REEEGDLLVKKLSKSSQTQTLVDLR 170 Query: 675 KSVQELTADIISHTAFGSSYKLGMEAFYAQKELQAIAISSLLNVQIPGFS-YLPTKRNRR 851 K+ TA II +FG +++ F L+ + S NV F+ + PT Sbjct: 171 KAFFSFTAGIIFRVSFGQNFREC--DFIDMDRLEELVQESETNVFSFAFTDFFPTGLG-- 226 Query: 852 KWMLEK-------------KLRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGGK 992 W++++ KL +I+ L S ++L+ ML+ + + G Sbjct: 227 -WLVDRISGQHSRIEKAFSKLTKFFQHVIDEELKIGQSQDHSNLVSSMLDMINRSTEYGS 285 Query: 993 QEQLSLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVG--KG 1166 ++ + ++ G ++ + WT+ L+ +P ++LR E+ +G K Sbjct: 286 ---FKITSDHLIAMMTDIVLGGVNAGTITMIWTMTELTRHPRVMKKLREEIRATLGPNKE 342 Query: 1167 DPSGDNLGKLKEMTMVLHETLRLYGPALFM-QRKTTTDMVVGAITIPKEHAIVIGAPFMH 1343 + ++L K++ + +V+ ET RL+ P F+ R+ +D+ + IPK I I + Sbjct: 343 RITEEDLEKVEYLKLVIKETFRLHPPGPFLLPRQVMSDIEIQGYHIPKNAHIKISTYAIG 402 Query: 1344 RDKKVWGEDADQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVL 1523 RD K W + ++FNP RFAN + LL F G R+C G + + + +L Sbjct: 403 RDPKCW-TNPEEFNPERFANTSINYKGQHYELLPFGAGRRSCPGMTLGITILELGLLNIL 461 Query: 1524 QKFSFAL 1544 F ++L Sbjct: 462 YYFDWSL 468
>Q9VMS7:C4AC3_DROME Probable cytochrome P450 4ac3 - Drosophila melanogaster (Fruit fly)| Length = 509 Score = 89.0 bits (219), Expect = 6e-17 Identities = 98/373 (26%), Positives = 164/373 (43%), Gaps = 35/373 (9%) Frame = +3 Query: 519 WVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASK-----NTNKEIQVEFDKSV 683 W R+ + PAF + + QS +F+E++ K + N ++E ++ + Sbjct: 139 WHTRRKTLTPAFHFNIL-----------QSFLSIFKEESKKFIKILDKNVGFELELNQII 187 Query: 684 QELTADIISHTAFG---------SSYKLGMEAF---YAQKELQAIAI------------- 788 + T + I TA G + Y+ + F + Q+ + Sbjct: 188 PQFTLNNICETALGVKLDDMSEGNEYRKAIHDFEIVFNQRMCNPLMFFNWYFFLFGDYKK 247 Query: 789 -SSLLNVQIPGFSYLPTKRNRRKWMLEKKLRSTLMRIINSRLASQGSGYGNDLLGLMLEG 965 S +L I GFS +R R+++ +K+L Q +G ML+ Sbjct: 248 YSRILRT-IHGFSSGIIQRKRQQFK-QKQL-------------GQVDEFGKKQRYAMLDT 292 Query: 966 CTETEQGGKQEQLSLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEV 1145 E GK + + I E TF F GY+TTS L +T+ LL+++ + QER E Sbjct: 293 LLAAEAEGK-----IDHQGICDEVNTFMFGGYDTTSTSLIFTLLLLALHADVQERCYEE- 346 Query: 1146 LREVGKG--DPSGDNLGKLKEMTMVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAI 1319 L+++ + + S +L + V+ E+LRL+ A + R + V+ + +PK I Sbjct: 347 LQDLPEDIDEVSMFQFNELIHLECVIKESLRLFPSAPIIGRTCIEESVMNGLVLPKNAQI 406 Query: 1320 VIGAPFMHRDKKVWGEDADQFNPMRFA--NGVARAAKVPHALLAFSIGPRACIGQNFAML 1493 I + RD + + + +QF P RF N V R P A + FS GPR CIGQ F +L Sbjct: 407 SIHIYDIMRDARHFPKP-NQFLPERFLPENSVNRH---PFAFVPFSAGPRNCIGQKFGVL 462 Query: 1494 EAKSVMATVLQKF 1532 E K ++A V++ F Sbjct: 463 EIKVLLAAVIRNF 475
>P30608:CP52F_CANTR Cytochrome P450 52A6 - Candida tropicalis (Yeast)| Length = 524 Score = 88.6 bits (218), Expect = 8e-17 Identities = 98/428 (22%), Positives = 165/428 (38%), Gaps = 29/428 (6%) Frame = +3 Query: 372 GAKPRICVFDYELVRQILSSKSGHFPKNDAHPNXXXXXXXXXXXXXXXDWVRHRRVIDPA 551 GA + E ++ +L+++ F H + W R ++ P Sbjct: 97 GALKIVLTVIQENIKAVLATQFTDFSLGTRHAHFYPLLGDGIFTLDGEGWKHSRAMLRPQ 156 Query: 552 FAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQELTADIISHTAFGSS 731 FA D+I V + + +Q N K ++ + T D + FG S Sbjct: 157 FARDQIGH-----VKALEPHIQILAKQIKLNKGKTFDIQ--ELFFRFTVDTATEFLFGES 209 Query: 732 YKLGMEAFYAQKELQAIAISSLLNVQIPGFSYLPTKRNRRKWMLEKKLRSTLM------- 890 + + Y +K + +IPG T N + L + S Sbjct: 210 ----VHSLYDEK------LGIPTPNEIPGRDNFATAFNTSQHYLATRTYSQTFYFLTNPK 259 Query: 891 --RIINSRLASQGSGYGNDLLGLMLEGCTETEQGGKQEQLSLSMEE-----ILHECKTFF 1049 R N+++ + N L E E + G L + + + Sbjct: 260 EFRDCNAKVHYLAKYFVNKALNFTPEEIEEKSKSGYVFLYELVKQTRDPKVLQDQLLNIM 319 Query: 1050 FAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGKGDPSG------DNLGKLKEMTM 1211 AG +TT+ LL++ +F L+ +PE +LR E+ G G+ S ++L + + + Sbjct: 320 VAGRDTTAGLLSFAMFELARHPEIWSKLREEIEVNFGVGEESRVEEITFESLKRCEYLKA 379 Query: 1212 VLHETLRLYGPALFMQRKTTTDMVV---------GAITIPKEHAIVIGAPFMHRDKKVWG 1364 +L+ETLR+Y R T D + I IPK + HR ++ +G Sbjct: 380 ILNETLRMYPSVPVNSRTATRDTTLPRGGGPNGTDPIFIPKGSTVAYIVYKTHRLEEYYG 439 Query: 1365 EDADQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFAL 1544 +DAD F P R+ + K+ A + F+ GPR C+GQ FA+ EA V+ ++Q F Sbjct: 440 KDADDFRPERWFEPSTK--KLGWAYVPFNGGPRICLGQQFALTEASYVITRLVQMFETVS 497 Query: 1545 SPSYVHAP 1568 SP V P Sbjct: 498 SPPDVEYP 505
>Q7Z449:CP2U1_HUMAN Cytochrome P450 2U1 - Homo sapiens (Human)| Length = 544 Score = 88.6 bits (218), Expect = 8e-17 Identities = 74/296 (25%), Positives = 123/296 (41%), Gaps = 8/296 (2%) Frame = +3 Query: 681 VQELTADIISHTAFGSSYKLGMEAFYAQKELQAIAISSLLNVQI------PGFSYLPTKR 842 + ++II FG + F + + LN Q+ P YLP Sbjct: 224 ISNAVSNIICSLCFGQRFDYTNSEFKKMLGFMSRGLEICLNSQVLLVNICPWLYYLPFGP 283 Query: 843 NRRKWMLEKKLRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGGKQEQLSLSMEE 1022 + +EK + S L +II S D + + L E + S E Sbjct: 284 FKELRQIEKDITSFLKKIIKDHQESLDRENPQDFIDMYLLHMEEERKNNSNS--SFDEEY 341 Query: 1023 ILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGKG-DPSGDNLGKLK 1199 + + F AG +TT+ L W + +S+ P+ QE++ E+ R +G PS + ++ Sbjct: 342 LFYIIGDLFIAGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIGANRAPSLTDKAQMP 401 Query: 1200 EMTMVLHETLRL-YGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDAD 1376 + E RL L + T+ + V+ TIPK I+ +HRD +W E + Sbjct: 402 YTEATIMEVQRLTVVVPLAIPHMTSENTVLQGYTIPKGTLILPNLWSVHRDPAIW-EKPE 460 Query: 1377 QFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFAL 1544 F P RF + + K + F IG R C+G+ A +E + +++Q F+FAL Sbjct: 461 DFYPNRFLDDQGQLIK-KETFIPFGIGKRVCMGEQLAKMELFLMFVSLMQSFAFAL 515
>Q9W683:CP1A1_LIZSA Cytochrome P450 1A1 - Liza saliens (Leaping mullet)| Length = 521 Score = 88.6 bits (218), Expect = 8e-17 Identities = 107/453 (23%), Positives = 174/453 (38%), Gaps = 27/453 (5%) Frame = +3 Query: 342 QYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHF---PKNDAHPNXXXXXXXXXXXXXX 512 +YG F G +P + + E VRQ L + F P + Sbjct: 74 RYGNVFQIQIGMRPVVVLSGNETVRQALIKQGDEFAGRPDLYSFRFISEGKSLAFSTDQA 133 Query: 513 XDWVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQV--------- 665 W R++ A T SC V EE SK IQ Sbjct: 134 GVWRARRKLAYSALRSFSTLEGTTPEYSC------VLEEHISKEAKYLIQQLDTVMKADG 187 Query: 666 EFD--KSVQELTADIISHTAFGSSYKLGMEAFYAQKELQAIAISSLLNVQ---------I 812 FD + + A++I FG Y + Q+ L + +S I Sbjct: 188 SFDPFRYIVVSVANVICGMCFGRRYD-----HHDQELLSLVNLSDEFGQVVGSGNPADFI 242 Query: 813 PGFSYLPTKRNRRKWMLEKKLRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGGK 992 P YLP K ++ + + S + +I++ A+ D+ +++ C E + + Sbjct: 243 PILQYLPNKTMKKFVSINDRFISFVQKIVSEHYATFNKDNIRDITDSLIDHC-EDRKLDE 301 Query: 993 QEQLSLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVG-KGD 1169 + +S E+++ F AG++T S L+W+V L YPE QE L E+ VG Sbjct: 302 NANVQMSDEKVVGIVNDLFGAGFDTISTALSWSVMYLVAYPEIQEXLYQELKENVGLDRT 361 Query: 1170 PSGDNLGKLKEMTMVLHETLRLYGPALF-MQRKTTTDMVVGAITIPKEHAIVIGAPFMHR 1346 P + L + + E R F + TT D + IPK+ + I ++ Sbjct: 362 PVLSDRNNLPLLESFILEIFRHSSFLPFTIPHCTTKDTSLNGYYIPKDTCVFINQWQINH 421 Query: 1347 DKKVWGEDADQFNPMRF--ANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATV 1520 D ++W E + FNP RF A+G ++ F +G R CIG+ A E +A + Sbjct: 422 DPELWKEPS-SFNPDRFLSADGTEVNKVDGEKVMIFGMGKRRCIGEVIARNEVYLFLAIL 480 Query: 1521 LQKFSFALSPSYVHAPADFLTLRPKFGLPVVMK 1619 +QK F + P + L + P++GL + K Sbjct: 481 IQKLHFC------NLPGEPLDMTPEYGLTMKHK 507
>Q9VYQ7:CP311_DROME Probable cytochrome P450 311a1 - Drosophila melanogaster (Fruit fly)| Length = 483 Score = 88.2 bits (217), Expect = 1e-16 Identities = 99/415 (23%), Positives = 172/415 (41%), Gaps = 6/415 (1%) Frame = +3 Query: 324 FLKWRAQYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHFPKNDAHPNXXXXXXXXXXX 503 F + R ++G + G + + + E RQ L + K D Sbjct: 56 FTELRDRFGATYRLRLGPQLWVFLHSAEETRQALHDPT--LRKADTFMQLEPLIGNGLLI 113 Query: 504 XXXXDWVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSV 683 W R RR++ PAF +++ + + G + +E + + Sbjct: 114 SHGAHWTRQRRLLTPAFQPQLLRSFAPAIGGHVERLVGRL------GATRGAFLEVTEPL 167 Query: 684 QELTADIISHTAFGSSYKLGMEAFYAQKELQAIAISSLLNVQIPGFSYLPTKRNRRKWML 863 D I T+ G+ +L ++ +QA +SS L + L + ++ L Sbjct: 168 FACLLDAIVDTSMGA--QLDTQSVDHSPIIQAFHLSSKLLFKRMINPLLSSDWIFQRTQL 225 Query: 864 EKKLRSTLMRIINSRLASQGSGYGNDLLGL-----MLEGCTETEQGGKQEQLSLSMEEIL 1028 + L L ++I+S++ S +LL + +T K E SLS EI Sbjct: 226 WRDLDEQL-QVIHSQMESVIEKRAKELLDMGEPAGRAHNLLDTLLLAKFEGQSLSRREIR 284 Query: 1029 HECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGKGDPSG-DNLGKLKEM 1205 E TF FAG +TT+ +++ ++ L+ +PE Q RLR E L++V + + D L L + Sbjct: 285 DEINTFVFAGVDTTTAAMSFVLYALAKFPETQTRLRKE-LQDVALDETTDLDALNGLPYL 343 Query: 1206 TMVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDADQFN 1385 ++ E LRLY R+TT +G T + I + DK+ + D F Sbjct: 344 EALIKEVLRLYTIVPTTGRQTTQSTEIGGRTYCAGVTLWINMYGLAHDKEYY-PDPYAFK 402 Query: 1386 PMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSP 1550 P R+ A + + FS GP CIG+ +++L K + A ++++F LSP Sbjct: 403 PERWLPEDGAVAPPAFSYIPFSGGPHVCIGRRYSLLLMKLLTARLVREFQMELSP 457
>Q04552:CP6B1_PAPPO Cytochrome P450 6B1 - Papilio polyxenes (Black swallowtail butterfly)| Length = 498 Score = 87.8 bits (216), Expect = 1e-16 Identities = 89/354 (25%), Positives = 149/354 (42%), Gaps = 16/354 (4%) Frame = +3 Query: 519 WVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQELTA 698 W R P F K+K+M M +E + + I VQ+ T Sbjct: 123 WRSLRNRFTPLFTSGKLKSMLPLMSQVGDRFINSIDEVSQTQPEQSIH----NLVQKFTM 178 Query: 699 DIISHTAFGSSYKLGMEAFYAQ--KELQAIAISSLLNVQIPGFSYLPTKRNRRKWMLEKK 872 I+ FG + GM K + + S+ L++ PG + L K Sbjct: 179 TNIAACVFGLNLDEGMLKTLEDLDKHIFTVNYSAELDMMYPGIL------KKLNGSLFPK 232 Query: 873 LRSTLMRIINSRLASQGSG---YGNDLLGLMLE-------GCTETEQGGKQEQLSLSMEE 1022 + S + + G Y D++ L+ E + + + L L+ Sbjct: 233 VVSKFFDNLTKNVLEMRKGTPSYQKDMIDLIQELREKKTLELSRKHENEDVKALELTDGV 292 Query: 1023 ILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGK--GDPSGDNLGKL 1196 I + F+ AGYET++ +T+ + L+ P+ Q++L AE+ + + G+ + + L ++ Sbjct: 293 ISAQMFIFYMAGYETSATTMTYLFYELAKNPDIQDKLIAEIDEVLSRHDGNITYECLSEM 352 Query: 1197 KEMTMVLHETLRLYGPALFMQRKTTTDMVVGA--ITIPKEHAIVIGAPFMHRDKKVWGED 1370 ++ V ETLR Y A F QR TD V ITI K I++ + D K + + Sbjct: 353 TYLSKVFDETLRKYPVADFTQRNAKTDYVFPGTDITIKKGQTIIVSTWGIQNDPKYY-PN 411 Query: 1371 ADQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKF 1532 ++F+P RF N + P A L FS GPR C+G FA +++ + VL K+ Sbjct: 412 PEKFDPERF-NPENVKDRHPCAYLPFSAGPRNCLGMRFAKWQSEVCIMKVLSKY 464
>P00185:CP1A1_RAT Cytochrome P450 1A1 - Rattus norvegicus (Rat)| Length = 524 Score = 87.4 bits (215), Expect = 2e-16 Identities = 98/453 (21%), Positives = 172/453 (37%), Gaps = 24/453 (5%) Frame = +3 Query: 318 PHF--LKWRAQYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHF---PKNDAHPNXXXX 482 PH K QYG+ G+ P + + ++Q L + F P + Sbjct: 63 PHLSLTKLSQQYGDVLQIRIGSTPVVVLSGLNTIKQALVKQGDDFKGRPDLYSFTLIANG 122 Query: 483 XXXXXXXXXXXDWVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQ 662 W RR+ A I + SC EE SK I Sbjct: 123 QSMTFNPDSGPLWAARRRLAQNALKSFSIASDPTLASSC------YLEEHVSKEAEYLIS 176 Query: 663 VEFDKSVQEL------------TADIISHTAFGSSYKLGMEAFYA----QKELQAIAISS 794 +F K + E+ A++I FG Y + + E + S Sbjct: 177 -KFQKLMAEVGHFDPFKYLVVSVANVICAICFGRRYDHDDQELLSIVNLSNEFGEVTGSG 235 Query: 795 LLNVQIPGFSYLPTKRNRRKWMLEKKLRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTE 974 IP YLP L KK S + ++I + G+ D+ ++E C + Sbjct: 236 YPADFIPILRYLPNSSLDAFKDLNKKFYSFMKKLIKEHYRTFEKGHIRDITDSLIEHCQD 295 Query: 975 TEQGGKQEQLSLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLRE 1154 + + LS ++++ F AG++T + ++W++ L P Q +++ E+ Sbjct: 296 RRLD-ENANVQLSDDKVITIVFDLFGAGFDTITTAISWSLMYLVTNPRIQRKIQEELDTV 354 Query: 1155 VGKG-DPSGDNLGKLKEMTMVLHETLRLYGPALF-MQRKTTTDMVVGAITIPKEHAIVIG 1328 +G+ P + +L + + ET R F + T D + IPK H + + Sbjct: 355 IGRDRQPRLSDRPQLPYLEAFILETFRHSSFVPFTIPHSTIRDTSLNGFYIPKGHCVFVN 414 Query: 1329 APFMHRDKKVWGEDADQFNPMRFANGVARAAK-VPHALLAFSIGPRACIGQNFAMLEAKS 1505 ++ D+++WG D ++F P RF K + ++ F +G R CIG+ LE Sbjct: 415 QWQVNHDQELWG-DPNEFRPERFLTSSGTLDKHLSEKVILFGLGKRKCIGETIGRLEVFL 473 Query: 1506 VMATVLQKFSFALSPSYVHAPADFLTLRPKFGL 1604 +A +LQ+ F +S P + + + P +GL Sbjct: 474 FLAILLQQMEFNVS------PGEKVDMTPAYGL 500
>Q92100:CP1A1_PLEPL Cytochrome P450 1A1 - Pleuronectes platessa (Plaice)| Length = 521 Score = 87.4 bits (215), Expect = 2e-16 Identities = 72/274 (26%), Positives = 123/274 (44%), Gaps = 4/274 (1%) Frame = +3 Query: 810 IPGFSYLPTKRNRRKWMLEKKLRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGG 989 IP YLP+ + + + + +I+ + D+ +++ C E + Sbjct: 242 IPILQYLPSAEMKNFLRINEHFTEFVQKIVTEHYTTFNKDNIRDITDSLIDHC-EDRKLD 300 Query: 990 KQEQLSLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGKGD 1169 + + +S E+I+ F AG++T S L+W+V L +PE QERL E+ +VG Sbjct: 301 ENSNVQMSDEKIVGIVNDLFGAGFDTVSTALSWSVMYLVAHPEIQERLYQEIEDKVGLDR 360 Query: 1170 -PSGDNLGKLKEMTMVLHETLRLYGPALF-MQRKTTTDMVVGAITIPKEHAIVIGAPFMH 1343 P + L + + E LR F + TT D + IPK+ + I ++ Sbjct: 361 MPLLSDKPNLPFLEAFILEILRHSSFLPFTIPHCTTKDTSLNGYFIPKDTCVFINQWQIN 420 Query: 1344 RDKKVWGEDADQFNPMRF--ANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMAT 1517 D ++W +D FNP RF A+G ++AF +G R CIG+ A E +A Sbjct: 421 HDPELW-KDPSSFNPDRFLSADGSEVNKLDGEKVMAFGMGKRRCIGEVIARNEVYLFLAI 479 Query: 1518 VLQKFSFALSPSYVHAPADFLTLRPKFGLPVVMK 1619 ++QK F + P + L + P++GL + K Sbjct: 480 IIQKLHF------LPIPGEKLDMTPEYGLTMKHK 507
>Q9YH64:CP1A1_PLAFE Cytochrome P450 1A1 - Platichthys flesus (European flounder)| Length = 521 Score = 87.4 bits (215), Expect = 2e-16 Identities = 72/274 (26%), Positives = 123/274 (44%), Gaps = 4/274 (1%) Frame = +3 Query: 810 IPGFSYLPTKRNRRKWMLEKKLRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGG 989 IP YLP+ + + + + +I+ + D+ +++ C E + Sbjct: 242 IPILQYLPSAAMKNFLRINSRFTEFVQKIVTEHYTTFDKDNIRDITDSLIDHC-EDRKLD 300 Query: 990 KQEQLSLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGKGD 1169 + + +S E+I+ F AG++T S L+W+V L +PE QERL E+ +VG Sbjct: 301 ENSNVQMSDEKIVGIVNDLFGAGFDTVSTALSWSVMYLVAHPEIQERLYQEIEDKVGLDR 360 Query: 1170 -PSGDNLGKLKEMTMVLHETLRLYGPALF-MQRKTTTDMVVGAITIPKEHAIVIGAPFMH 1343 P + L + + E LR F + TT D + IPK+ + I ++ Sbjct: 361 MPLLSDKPNLPFLEAFILEILRHSSFLPFTIPHCTTKDTSLNGYFIPKDTCVFINQWQIN 420 Query: 1344 RDKKVWGEDADQFNPMRF--ANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMAT 1517 D ++W +D FNP RF A+G ++AF +G R CIG+ A E +A Sbjct: 421 HDPELW-KDPSSFNPDRFLSADGSEVNKLDGEKVMAFGMGKRRCIGEVIARNEVYLFLAI 479 Query: 1518 VLQKFSFALSPSYVHAPADFLTLRPKFGLPVVMK 1619 ++QK F + P + L + P++GL + K Sbjct: 480 IIQKLHF------LPIPGEKLDMTPEYGLTMKHK 507
>O77810:CP1A2_CALJA Cytochrome P450 1A2 - Callithrix jacchus (Common marmoset)| Length = 516 Score = 87.0 bits (214), Expect = 2e-16 Identities = 95/447 (21%), Positives = 169/447 (37%), Gaps = 18/447 (4%) Frame = +3 Query: 318 PHFL--KWRAQYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHF---PKNDAHPNXXXX 482 PH K +YG+ G+ P + + + +RQ L + F P + Sbjct: 61 PHLALTKMSQRYGDVLQIHIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYSFTLITDG 120 Query: 483 XXXXXXXXXXXDWVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQ 662 W RR+ A I + + SC E +A +E+ Sbjct: 121 QSMSFSPDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAEALIGRLQELM 180 Query: 663 V---EFD--KSVQELTADIISHTAFGSSYKLGMEAFYAQKELQAIAISSLLNVQ----IP 815 FD + E +I FG + + + + + + + + P Sbjct: 181 AGPGRFDPYNQIVESVVKVIGAMCFGQHFPESSDEMLSLMKNSHVFVENATSGNPVDFFP 240 Query: 816 GFSYLPTKRNRRKWMLEKKLRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGGKQ 995 YLP +R ++ L + D+ G + + C + + G Sbjct: 241 ILRYLPNPALQRFKAFNQRFLRFLRETVQEHYQDSDKNSVQDITGALFKHCEK--RSGAS 298 Query: 996 EQLSLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGKG-DP 1172 L + E+I++ F AG++T + ++W++ L PE Q +++ E+ +G+G P Sbjct: 299 GDL-IPQEKIVNLVNDIFGAGFDTITTAISWSLMYLVTKPEIQRKIQKELDTVIGRGRRP 357 Query: 1173 SGDNLGKLKEMTMVLHETLRLYGPALF-MQRKTTTDMVVGAITIPKEHAIVIGAPFMHRD 1349 + +L + + ET R F + TT D + IPKE + I ++ D Sbjct: 358 RLSDRPQLPYLEAFILETFRHSSFVPFTIPHSTTRDTTLKGFYIPKECCVFINQWQVNHD 417 Query: 1350 KKVWGEDADQFNPMRF--ANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVL 1523 ++WG D +F P RF A G A + +L F +G R CIG+ E +A +L Sbjct: 418 PQLWG-DPSEFRPERFLTAKGTALNKPLSEKILLFGLGKRRCIGEVLGKWEVFLFLAILL 476 Query: 1524 QKFSFALSPSYVHAPADFLTLRPKFGL 1604 Q+ F++ P + L P +GL Sbjct: 477 QQLEFSVPPGVQ------IDLTPTYGL 497
>P33616:CP1A1_MACFA Cytochrome P450 1A1 - Macaca fascicularis (Crab eating macaque)| (Cynomolgus monkey) Length = 512 Score = 87.0 bits (214), Expect = 2e-16 Identities = 65/250 (26%), Positives = 114/250 (45%), Gaps = 3/250 (1%) Frame = +3 Query: 810 IPGFSYLPTKRNRRKWMLEKKLRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGG 989 IP YLP + L +K S + ++I + GY D+ ++E C E +Q Sbjct: 237 IPILRYLPNRSLNGFKDLNEKFHSFMQKMIKEHYKTFEKGYIRDITDSLIEHCQE-KQLD 295 Query: 990 KQEQLSLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGKG- 1166 + + LS E+I++ F AG++T + ++W++ L P Q +++ E+ +G+ Sbjct: 296 ENANIQLSDEKIVNVVLDLFGAGFDTVTTAISWSLMYLVTNPRVQRKIQEELDTVIGRSR 355 Query: 1167 DPSGDNLGKLKEMTMVLHETLRLYGPALF-MQRKTTTDMVVGAITIPKEHAIVIGAPFMH 1343 P + L M + ET R F + TT D + IPK + + ++ Sbjct: 356 RPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQIN 415 Query: 1344 RDKKVWGEDADQFNPMRFANGVARAAKV-PHALLAFSIGPRACIGQNFAMLEAKSVMATV 1520 D+K+W + +F P RF KV ++ F +G R CIG+ A E +A + Sbjct: 416 HDQKLW-VNPSEFLPERFITPDGAIDKVLSEKVILFGLGKRKCIGETIARWEVFLFLAIL 474 Query: 1521 LQKFSFALSP 1550 LQ+ F++ P Sbjct: 475 LQRVEFSVPP 484
>Q9W011:C4D20_DROME Probable cytochrome P450 4d20 - Drosophila melanogaster (Fruit fly)| Length = 510 Score = 87.0 bits (214), Expect = 2e-16 Identities = 108/449 (24%), Positives = 174/449 (38%), Gaps = 41/449 (9%) Frame = +3 Query: 303 LHRVAPHFLKWRAQ----YGEPFLFWFGAKPRICVFDYELVRQILSSKSGHFPKNDAHPN 470 LH A + + W + YG+ F FW + I D + ILSS + K + Sbjct: 49 LHLGAENIIGWVGEKFDKYGKTFRFWILGESLIYTKDLQYFETILSSTT-LLEKGQLYEY 107 Query: 471 XXXXXXXXXXXXXXXDWVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTN 650 W R++ AF ++ + M V + K + Sbjct: 108 LRPFLNDGLLVSTGRKWHARRKIFTHAFHFKVLEHYVEIM----DRHSSVMVDNLRKVAD 163 Query: 651 KEIQVEFDKSVQELTADIISHTAFGSSYKLGMEAFYAQKELQAIAISSLLNVQIPGFSYL 830 + V+ K V D+I+ A G AQ + I +L +V + Sbjct: 164 GKTAVDMLKYVSLAALDVITEAAMGVQVN-------AQNDPDFPYIKALKSVVYIQPDRM 216 Query: 831 PTKRNRRKWM-------LEKKLRSTLM-------RIINSRL------------------- 911 R W+ L ++L S + ++I+ R Sbjct: 217 FRFSRRYNWLFPLAAPLLHRQLLSDIRVMHDFTDKVISERRETVRRAKADGTYRPLSLGD 276 Query: 912 ASQGSGYGNDLLGLMLEGCTETEQGGKQEQLSLSMEEILHECKTFFFAGYETTSLLLTWT 1091 A GS LL ++L+ + LS +I E TF F G +TTS ++ Sbjct: 277 AEIGSKSQMALLDILLQSSINNQP--------LSDADIREEVDTFMFEGDDTTSSGVSHA 328 Query: 1092 VFLLSVYPEWQERLRAEVLREVGKGDPSGD----NLGKLKEMTMVLHETLRLYGPALFMQ 1259 ++ ++ +PE Q+R+ E+ R +G D S L LK + V+ ET+RLY P + Sbjct: 329 LYAIARHPEVQQRIFEELQRVLGP-DASAPVTQAQLQDLKYLDCVIKETMRLYPPVPAIG 387 Query: 1260 RKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDADQFNPMRFANGVARAAKVPHAL 1439 R ++ +G TIP +I + + HRD + D F P RF + A Sbjct: 388 RHAQKELEIGDKTIPANTSIYLVLYYAHRDANYF-PDPLSFRPERFLEDQEQGHNT-FAY 445 Query: 1440 LAFSIGPRACIGQNFAMLEAKSVMATVLQ 1526 + FS GP+ CIGQ FA+LE K +++ VL+ Sbjct: 446 VPFSAGPKNCIGQKFAVLEMKVLISKVLR 474
>Q9V675:CP6G2_DROME Probable cytochrome P450 6g2 - Drosophila melanogaster (Fruit fly)| Length = 519 Score = 86.7 bits (213), Expect = 3e-16 Identities = 98/427 (22%), Positives = 173/427 (40%), Gaps = 32/427 (7%) Frame = +3 Query: 378 KPRICVFDYELVRQILSSKSGHFPK--NDAHPNXXXXXXXXXXXXXXXDWVRHRRVIDPA 551 KP + + D E+VR IL F + + P W R + P Sbjct: 80 KPALLLRDPEMVRNILVKDFAGFSNRYSSSDPKGDPLGSQNIFFLKNPAWKEVRLKLSPF 139 Query: 552 FAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQEL----TADIISHTA 719 F +++K M + S +Q N FD +EL T D+I+ A Sbjct: 140 FTGNRLKQMFPLIEEVGASLDAHLRQQPLHNERMRC---FDLEAKELCALYTTDVIATVA 196 Query: 720 FGSS----------YKLGMEAFYAQKELQAIAISSLLN----VQIPGFSYLPTKRNRRKW 857 +G S ++ + + L+A + + V F +P + R Sbjct: 197 YGVSANSFTDPKCEFRRHGRSVFEFNLLRAAEFTLVFFLPHLVPFVRFKVVPAEATRF-- 254 Query: 858 MLEKKLRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETE---QGGKQEQLSLSMEEIL 1028 LR T+ +++ R + NDL+ +++E T+ G ++Q + ++ Sbjct: 255 -----LRKTINYVMSER--EKSGQKRNDLIDILIEFRRSTQLAKASGIKDQFVFEGDILV 307 Query: 1029 HECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEV---LREVGKGDPSGDNLGKLK 1199 + FF AG+E++S + + ++ L+ + Q+RLR E+ L E G G + + L+ Sbjct: 308 AQAVLFFTAGFESSSSTMAFAMYELAKDTDVQQRLREEIKDALVESG-GQVTLKMIESLE 366 Query: 1200 EMTMVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPF------MHRDKKVW 1361 M M+L E LR+Y P F+ R+ T+ K+ + G P +H D + + Sbjct: 367 FMQMILLEVLRMYPPLPFLDRECTSGRDYSLAPFHKKFVVPKGMPVYIPCYALHMDPQYF 426 Query: 1362 GEDADQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFA 1541 + +F P RF+ R P+ + F +GP CIG+ F L+AK + +L+ Sbjct: 427 PQPR-KFLPERFSPE-NRKLHTPYTYMPFGLGPHGCIGERFGYLQAKVGLVNLLRNHMIT 484 Query: 1542 LSPSYVH 1562 S H Sbjct: 485 TSERTPH 491
>Q12588:CP52J_CANMA Cytochrome P450 52A10 - Candida maltosa (Yeast)| Length = 519 Score = 86.7 bits (213), Expect = 3e-16 Identities = 71/204 (34%), Positives = 103/204 (50%), Gaps = 18/204 (8%) Frame = +3 Query: 1053 AGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGKG------DPSGDNLGKLKEMTMV 1214 AG +TT+ LL++ VF L PE +LR E+ + G D S + L + + V Sbjct: 315 AGRDTTAGLLSFAVFELGRNPEVWSKLRQEIGHKFGLDSYSRVEDISFELLKLCEYLKAV 374 Query: 1215 LHETLRLYGP----ALFMQRKTTTDMVVGA-----ITIPKEHAIVIGAPFMHRDKKVWGE 1367 L+ETLRLY A F + TT G I + K ++ + RD+K +G+ Sbjct: 375 LNETLRLYPSVPRNARFAAKNTTLPHGGGPDGMSPILVRKGQTVMYSVYALQRDEKYYGK 434 Query: 1368 DADQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKF-SFAL 1544 DA++F P R+ R K+ A L F+ GPR C+GQ FA+ EA V+A ++Q F + L Sbjct: 435 DANEFRPERWFEPEVR--KLGWAFLPFNGGPRICLGQQFALTEASYVLARLIQSFETLEL 492 Query: 1545 SPSYVHAPA--DFLTLRPKFGLPV 1610 SP + PA LT+ G PV Sbjct: 493 SPEAAYPPAKLSHLTMCLFDGTPV 516
>Q92109:CP1A3_ONCMY Cytochrome P450 1A3 - Oncorhynchus mykiss (Rainbow trout) (Salmo| gairdneri) Length = 522 Score = 86.7 bits (213), Expect = 3e-16 Identities = 72/274 (26%), Positives = 120/274 (43%), Gaps = 4/274 (1%) Frame = +3 Query: 810 IPGFSYLPTKRNRRKWMLEKKLRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGG 989 IP YLP + +R + + + + +I++ S D+ +++ C E + Sbjct: 242 IPILRYLPNRTMKRFMDINDRFNNFVQKIVSEHYESYDKDNIRDITDSLIDHC-EDRKLD 300 Query: 990 KQEQLSLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGK-G 1166 + + +S E+I+ F AG++T S L+W V L YPE QERL E+ +VG Sbjct: 301 ENANIQVSDEKIVGIVNDLFGAGFDTISTALSWAVVYLVAYPETQERLHQELKEKVGMIR 360 Query: 1167 DPSGDNLGKLKEMTMVLHETLRLYGPALF-MQRKTTTDMVVGAITIPKEHAIVIGAPFMH 1343 P + L + + E R F + T D + IPK+ + I ++ Sbjct: 361 TPRLSDKINLPLLEAFILEIFRHSSFLPFTIPHCTIKDTSLNGYFIPKDTCVFINQWQVN 420 Query: 1344 RDKKVWGEDADQFNPMRF--ANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMAT 1517 D ++W E + FNP RF A+G +L F +G R CIG+ E +A Sbjct: 421 HDPELWKEPS-SFNPDRFLSADGTELNKLEGEKVLVFGMGKRRCIGEAIGRNEVYLFLAI 479 Query: 1518 VLQKFSFALSPSYVHAPADFLTLRPKFGLPVVMK 1619 +LQ+ F P + L + P++GL + K Sbjct: 480 LLQRLRFQEKPGHP------LDMTPEYGLTMKHK 507
>P11715:CP17A_RAT Cytochrome P450 17A1 - Rattus norvegicus (Rat)| Length = 507 Score = 86.7 bits (213), Expect = 3e-16 Identities = 94/423 (22%), Positives = 166/423 (39%), Gaps = 14/423 (3%) Frame = +3 Query: 321 HFLKWRAQYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHF---PKNDAHPNXXXXXXX 491 +F K + +YG + G + + Y+L R++L K F P+ Sbjct: 52 NFFKLQEKYGPIYSLRLGTTTTVIIGHYQLAREVLIKKGKEFSGRPQMVTQSLLSDQGKG 111 Query: 492 XXXXXXXXDWVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEF 671 W HR+++ F++ K + ++ C ++ A + ++ Sbjct: 112 VAFADAGSSWHLHRKLVFSTFSLFKDGQKLEKLI-CQEAKSLCDMMLAHDKESIDLSTPI 170 Query: 672 DKSVQELTADIISHTAFGSSY-----KLGMEAFYAQKELQAIAISSLLNVQIPGFSYLPT 836 SV +II F SY KL + + + A +L+++ P + P Sbjct: 171 FMSV----TNIICAICFNISYEKNDPKLTAIKTFTEGIVDATGDRNLVDI-FPWLTIFPN 225 Query: 837 KRNRRKWMLEKKLRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGGKQEQLS--- 1007 K K L I S + L ++++ ++ E Sbjct: 226 KGLEVIKGYAKVRNEVLTGIFEKCREKFDSQSISSLTDILIQAKMNSDNNNSCEGRDPDV 285 Query: 1008 LSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVG-KGDPSGDN 1184 S IL F AG ETT+ +L W + L PE +++++ E+ + VG P+ ++ Sbjct: 286 FSDRHILATVGDIFGAGIETTTTVLKWILAFLVHNPEVKKKIQKEIDQYVGFSRTPTFND 345 Query: 1185 LGKLKEMTMVLHETLRLYGPA-LFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVW 1361 L + + E LR+ A + + K D +G T+PK+ +V+ +H D+ W Sbjct: 346 RSHLLMLEATIREVLRIRPVAPMLIPHKANVDSSIGEFTVPKDTHVVVNLWALHHDENEW 405 Query: 1362 GEDADQFNPMRFANGVARAAKVP-HALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSF 1538 + DQF P RF + P + L F GPR+CIG+ A E A +LQ+F Sbjct: 406 -DQPDQFMPERFLDPTGSHLITPTQSYLPFGAGPRSCIGEALARQELFVFTALLLQRFDL 464 Query: 1539 ALS 1547 +S Sbjct: 465 DVS 467
>Q9V559:CP4P3_DROME Probable cytochrome P450 4p3 - Drosophila melanogaster (Fruit fly)| Length = 515 Score = 86.3 bits (212), Expect = 4e-16 Identities = 56/173 (32%), Positives = 91/173 (52%), Gaps = 3/173 (1%) Frame = +3 Query: 1023 ILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGK--GDPSGDNLGKL 1196 I E T F GY+TTS+ L + + +S+YPE QE+ E+ + + L KL Sbjct: 312 ICEEVDTLMFEGYDTTSIGLMFGLMNMSLYPEEQEKCYQEIQANIDDELNILNIGQLNKL 371 Query: 1197 KEMTMVLHETLRLYGPALFMQRKTTTDMVVG-AITIPKEHAIVIGAPFMHRDKKVWGEDA 1373 K + + ET+RL+ M R+TT + + + +PK I + +HR+ + W + Sbjct: 372 KNLEYFIKETMRLFPSVPAMGRETTRETELSNGLILPKGSQIFVHVFDIHRNPEYW-DSP 430 Query: 1374 DQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKF 1532 ++F P RF ++ +A + FS G R CIGQ FAM E K++M +L++F Sbjct: 431 EEFRPERFLPENSQNRHT-YAYIPFSAGQRNCIGQKFAMQEMKTLMVALLKQF 482
>Q9LTM3:C71BK_ARATH Cytochrome P450 71B20 - Arabidopsis thaliana (Mouse-ear cress)| Length = 502 Score = 86.3 bits (212), Expect = 4e-16 Identities = 79/331 (23%), Positives = 143/331 (43%), Gaps = 15/331 (4%) Frame = +3 Query: 627 EQASKNTNKEIQVEFDKSVQELTADIISHTAFGSSY---------KLGMEAFYAQKELQA 779 +Q S++ V+ KS+ LTA I A G ++ K+ F A+ L + Sbjct: 155 KQLSESAVNRSPVDLSKSLFWLTASIFFRVALGQNFHESNFIDKEKIEELVFEAETALAS 214 Query: 780 IAISSLLNVQIPGFSYLP---TKRNRRKWMLEKKLRSTLMRIINSRLASQGSGYGNDLLG 950 S V G +L + +++R + KL + +I+ L S D++ Sbjct: 215 FTCSDFFPVA--GLGWLVDWFSGQHKRLNDVFYKLDALFQHVIDDHLNPGRSKEHEDIID 272 Query: 951 LMLEGCTETEQGGKQEQLSLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQER 1130 ML+ + GK L L ++ I F AG +T +L + W + L P+ ++ Sbjct: 273 SMLDAI---HKEGKDSSLELIIDHIKGFLANIFLAGIDTGALTMIWAMTELVKNPKLIKK 329 Query: 1131 LRAEVLREVG--KGDPSGDNLGKLKEMTMVLHETLRLYGPA-LFMQRKTTTDMVVGAITI 1301 ++ E+ ++G K + +++ K+ + MV+ ET RL+ A L + R+T + V I Sbjct: 330 VQGEIREQLGSNKARITEEDIDKVPYLKMVIKETFRLHPAAPLILPRETMAHIKVQGYDI 389 Query: 1302 PKEHAIVIGAPFMHRDKKVWGEDADQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQN 1481 P + I++ + RD K+W + ++F+P RF + + LL F G R C G Sbjct: 390 PPKRRILVNVSAIGRDPKLW-TNPEEFDPERFMDSSVDYRGQHYELLPFGSGRRICPGMP 448 Query: 1482 FAMLEAKSVMATVLQKFSFALSPSYVHAPAD 1574 + + + +L F + L H D Sbjct: 449 MGIAAVELGLLNLLYFFDWKLPDGMTHKDID 479
>Q9V773:C6A20_DROME Probable cytochrome P450 6a20 - Drosophila melanogaster (Fruit fly)| Length = 501 Score = 86.3 bits (212), Expect = 4e-16 Identities = 97/431 (22%), Positives = 178/431 (41%), Gaps = 13/431 (3%) Frame = +3 Query: 330 KWRAQYGEPFL-FWFGAKPRICVFDYELVRQILSSKSGHFPKNDA-HPNXXXXXXXXXXX 503 K R + PF+ F+ K + V D + + +L + F H Sbjct: 62 KLRNKTDGPFVGFYMYFKRMVVVTDIDFAKTVLIREFDKFHDRGVFHNERDDPLSANLVN 121 Query: 504 XXXXDWVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSV 683 W R+ + P F K+K M T+++ VF E AS +++ +E V Sbjct: 122 IDGQKWKTLRQKLTPTFTSGKMKTMFPTILTVGDELIRVFGETASADSDS---MEITNVV 178 Query: 684 QELTADIISHTAFG-SSYKLG-MEAFYAQKELQAIAI---SSLLNVQIPGFSYLPTKRNR 848 TAD+I AFG + L +A + Q AI +++ + G L K Sbjct: 179 ARFTADVIGSCAFGLDCHSLSDPKAKFVQMGTTAITERRHGKSMDLLLFGAPELAAKLRM 238 Query: 849 RKWMLEKKLRSTLMRIINSRL--ASQGSGYGNDLLGLMLEGCTETEQGGKQEQLSLSMEE 1022 + + E + M II + + + +D + +++E + + G K+ L+ E Sbjct: 239 KATVQE--VEDFYMNIIRDTVDYRVKNNVKRHDFVDMLIEMKLKFDNGDKEN--GLTFNE 294 Query: 1023 ILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEV--LREVGKGDPSGDNLGKL 1196 I + FF AG+ET+S + + ++ L+ + + Q++LR E+ + + G D++ ++ Sbjct: 295 IAAQAFIFFLAGFETSSTTMGFALYELACHQDIQDKLRTEINTVLKQHNGKLDYDSMREM 354 Query: 1197 KEMTMVLHETLRLYGPALFMQRKTTT--DMVVGAITIPKEHAIVIGAPFMHRDKKVWGED 1370 + V+ ET+R + R T I K +++ +H D + + E Sbjct: 355 TYLEKVIDETMRKRPVVGHLIRVATQHYQHTNPKYNIEKGTGVIVPTLAIHHDPEFYPE- 413 Query: 1371 ADQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSP 1550 ++F P RF + + L F GPR CIG F ++ MA ++ F F P Sbjct: 414 PEKFIPERFDEDQVQ-QRPACTFLPFGDGPRNCIGLRFGRMQVIVGMALLIHNFKFEFHP 472 Query: 1551 SYVHAPADFLT 1583 + P ++ T Sbjct: 473 TKTVVPLEYRT 483
>Q9VMT6:C28D2_DROME Probable cytochrome P450 28d2 - Drosophila melanogaster (Fruit fly)| Length = 501 Score = 86.3 bits (212), Expect = 4e-16 Identities = 85/364 (23%), Positives = 150/364 (41%), Gaps = 19/364 (5%) Frame = +3 Query: 516 DWVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQELT 695 +W R I PA + +++KA+ S + Q T++ + D S+ T Sbjct: 131 EWKERRSEIMPALSPNRVKAVYPVSQSVCKKFVEYIRRQQQMATSEGLDA-MDLSLC-YT 188 Query: 696 ADIISHTAFGSS-----------YKLGMEAFYAQKELQAIAISSLLNVQIPGFSYLPTKR 842 +++S G S K+ F E ++ + L ++ F +P Sbjct: 189 TEVVSDCGLGVSAQSFTDTPTPLLKMIKRVFNTSFEFIFYSVVTNLWQKVRKFYSVPFFN 248 Query: 843 NRRKWMLEKKLRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGGKQEQLSLSMEE 1022 + +R R I RL + +D L ML+ QE+ L + Sbjct: 249 KETEVFFLDIIR----RCITLRL-EKPEQQRDDFLNYMLQ---------LQEKKGLHTDN 294 Query: 1023 ILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGKGDPSGDNLGKLKE 1202 IL TF G+ETT+L+L + +L PE Q+++R +E+G D + D + +L Sbjct: 295 ILINTMTFILDGFETTALVLAHIMLMLGRNPEEQDKVR----KEIGSADLTFDQMSELPH 350 Query: 1203 MTMVLHETLRLYGPALFMQRKTTTDMVVG-----AITIPKEHAIVIGAPFMHRDKKVWGE 1367 + ++ETLRL+ P + ++ T + + + I +H D + + E Sbjct: 351 LDACIYETLRLFSPQVAARKLVTEPFEFANKNGRTVHLKPGDVVTIPVKALHHDPQYY-E 409 Query: 1368 DADQFNPMRFAN---GVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSF 1538 D F P RF G ++ + LAF GPR C G FA+ + K+ + +L+ F Sbjct: 410 DPLTFKPERFLESNGGGMKSYRDRGVYLAFGDGPRHCPGMRFALTQLKAALVEILRNFEI 469 Query: 1539 ALSP 1550 ++P Sbjct: 470 KVNP 473
>O42430:CP1A1_LIMLI Cytochrome P450 1A1 - Limanda limanda (Dab)| Length = 521 Score = 85.9 bits (211), Expect = 5e-16 Identities = 72/274 (26%), Positives = 123/274 (44%), Gaps = 4/274 (1%) Frame = +3 Query: 810 IPGFSYLPTKRNRRKWMLEKKLRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGG 989 IP YLP+ + + + + +I+ + D+ +++ C E + Sbjct: 242 IPILQYLPSATMKNFLRINGRFTEFVQKIVTEHYTTFDKDNIRDITDSLIDHC-EDRKLD 300 Query: 990 KQEQLSLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGKGD 1169 + + +S E+I+ F AG++T S L+W+V L +PE QERL E+ +VG Sbjct: 301 ENSNVQMSDEKIVGIVNDLFGAGFDTVSTALSWSVMYLVAHPEIQERLYQEIEDKVGLDR 360 Query: 1170 -PSGDNLGKLKEMTMVLHETLRLYGPALF-MQRKTTTDMVVGAITIPKEHAIVIGAPFMH 1343 P + L + + E LR F + TT D + IPK+ + I ++ Sbjct: 361 MPLLSDKPNLPFLEAFILEILRHSSFLPFTIPHCTTKDTSLNGYFIPKDTCVFINQWQIN 420 Query: 1344 RDKKVWGEDADQFNPMRF--ANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMAT 1517 D ++W +D FNP RF A+G ++AF +G R CIG+ A E +A Sbjct: 421 HDPEMW-KDPSSFNPDRFLSADGSEVNKLDGEKVMAFGMGKRRCIGEVIARNEVYLFLAI 479 Query: 1518 VLQKFSFALSPSYVHAPADFLTLRPKFGLPVVMK 1619 ++QK F + P + L + P++GL + K Sbjct: 480 LIQKLHF------LPIPGEKLDMTPEYGLTMKHK 507
>P00187:CP1A2_RABIT Cytochrome P450 1A2 - Oryctolagus cuniculus (Rabbit)| Length = 516 Score = 85.5 bits (210), Expect = 7e-16 Identities = 98/444 (22%), Positives = 176/444 (39%), Gaps = 23/444 (5%) Frame = +3 Query: 342 QYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHFP-KNDAHPNXXXXXXXXXXXXXXXD 518 +YG+ F G+ P + + + ++Q L + F + D + + Sbjct: 71 RYGDVFQIRLGSTPVVVLSGLDTIKQALVRQGDDFKGRPDLYSSSFITEGQSMTFSPDSG 130 Query: 519 --WVRHRRVIDPAFAMDKIKAMTKTMVSC---------AQSTFGVFEEQASKNTNKEIQV 665 W RR+ + I + + SC A++ G F+E + Sbjct: 131 PVWAARRRLAQDSLKSFSIASNPASSSSCYLEEHVSQEAENLIGRFQELMAAVGR----- 185 Query: 666 EFDKSVQELT--ADIISHTAFGSSYKLGMEAFY-----AQKELQAIAISSLLNVQIPGFS 824 FD Q + A +I FG + G E + K ++ + S ++ P Sbjct: 186 -FDPYSQLVVSAARVIGAMCFGRRFPQGSEEMLDVVRNSSKFVETASSGSPVDF-FPILR 243 Query: 825 YLPTKRNRRKWMLEKKLRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGGKQEQL 1004 YLP + +R ++ L + + D+ G + + +E+ K Sbjct: 244 YLPNRPLQRFKDFNQRFLRFLQKTVREHYEDFDRNSIQDITGALFK---HSEKNSKANSG 300 Query: 1005 SLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGKG-DPSGD 1181 + E+I++ F AG++T + L+W++ L P Q +++ E+ VG+ P Sbjct: 301 LIPQEKIVNLVNDIFGAGFDTITTALSWSLMYLVTNPRRQRKIQEELDAVVGRARQPRLS 360 Query: 1182 NLGKLKEMTMVLHETLRLYGPALF-MQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKV 1358 + +L + + E R F + TT D + IPKE I I ++ D ++ Sbjct: 361 DRPQLPYLEAFILELFRHTSFVPFTIPHSTTRDTTLNGFHIPKECCIFINQWQINHDPQL 420 Query: 1359 WGEDADQFNPMRF--ANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKF 1532 WG D ++F P RF A+G A + + F +G R CIG+ A E +A +LQ+ Sbjct: 421 WG-DPEEFRPERFLTADGAAINKPLSEKVTLFGLGKRRCIGETLARWEVFLFLAILLQRL 479 Query: 1533 SFALSPSYVHAPADFLTLRPKFGL 1604 F++ P P D L P +GL Sbjct: 480 EFSVPPG---VPVD---LTPIYGL 497
>Q92095:CP1A1_OPSTA Cytochrome P450 1A1 - Opsanus tau (Oyster toadfish)| Length = 521 Score = 85.5 bits (210), Expect = 7e-16 Identities = 102/449 (22%), Positives = 177/449 (39%), Gaps = 23/449 (5%) Frame = +3 Query: 342 QYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHF---PKNDAHPNXXXXXXXXXXXXXX 512 +YG F G +P + + E VRQ L + F P Sbjct: 74 RYGPVFQIQIGMRPVVVLSGSETVRQALIKQGEDFSGRPDLYTFQFISDGKSLAFSTDKV 133 Query: 513 XDWVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASK---------NTNKEIQV 665 W R++ A T SC + EE K NT+ + Sbjct: 134 GVWRARRKLAYSALRSFSSLESTNQEYSC------MLEEHICKEGEYLVKQLNTSMKANG 187 Query: 666 EFD--KSVQELTADIISHTAFGSSYKLGMEAFYAQKEL-----QAIAISSLLNVQIPGFS 824 FD +++ A++I FG Y + + L Q + +L + IP Sbjct: 188 SFDPFRNIVVSVANVICGMCFGRRYDHYDQELVSLVNLSEEFGQVVGTGNLADF-IPVLR 246 Query: 825 YLPTKRNRRKWMLEKKLRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGGKQEQL 1004 +LP+ ++ + + + +I++ A+ D+ +++ C E + + + Sbjct: 247 FLPSTAMKKFLSINDRFDKFVKKIVSEHYATYNKDNIRDITDSLIDHC-EDRKLDENCNV 305 Query: 1005 SLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVG-KGDPSGD 1181 +S E+I+ F AG++T S L+W+V L YPE QERL E+ VG + P Sbjct: 306 QVSDEKIVGIVNDLFGAGFDTVSTGLSWSVMYLVAYPEIQERLYQEIKDSVGTERMPLLS 365 Query: 1182 NLGKLKEMTMVLHETLRLYGPALF-MQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKV 1358 + L + + E R F + TT + + IPK+ + I ++ D ++ Sbjct: 366 DRPSLPFLDAFILEIFRHSSFLPFTIPHCTTKNTSLNGYFIPKDTCVFINQWQINHDPEL 425 Query: 1359 WGEDADQFNPMRF--ANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKF 1532 W +D FNP RF A+G ++ F +G R CIG+ A E +A ++Q+ Sbjct: 426 W-KDPFSFNPERFLSADGTELNRLEGEKVMLFGLGKRRCIGEVIARNEVFLFLAIIIQRL 484 Query: 1533 SFALSPSYVHAPADFLTLRPKFGLPVVMK 1619 F + P + L + P++GL + K Sbjct: 485 QFHM------LPGEPLDMTPEYGLTMKHK 507
>Q12573:CP52W_CANAP Cytochrome P450 52E2 - Candida apicola (Yeast)| Length = 519 Score = 85.1 bits (209), Expect = 9e-16 Identities = 56/183 (30%), Positives = 85/183 (46%), Gaps = 12/183 (6%) Frame = +3 Query: 1023 ILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGKGD---PSGDNLGK 1193 I + AG +TT+ LL++T + L YPE + LR V+ + G D P+ + L + Sbjct: 302 IRDQALNILLAGRDTTAALLSFTTYYLGAYPEVYDELREAVIADFGSADAEPPTFEQLKQ 361 Query: 1194 LKEMTMVLHETLRLYG--PALFMQRKTTTDMVVGA-------ITIPKEHAIVIGAPFMHR 1346 K + V+ E LRL+ P F + T G I +PK + M R Sbjct: 362 CKVLQNVIREVLRLHPNVPLNFREAIADTTFPTGGGPNGDQPIFVPKGQKVFYATYVMQR 421 Query: 1347 DKKVWGEDADQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQ 1526 + +WG D+ F P R+ N A + F+ GPR C+GQ FA+ EA + + Q Sbjct: 422 NAGIWGPDSTSFRPDRW-NEPREALASGWDYIPFNGGPRICLGQQFALTEASYTLVRICQ 480 Query: 1527 KFS 1535 +FS Sbjct: 481 EFS 483
>Q00557:CP1A1_MESAU Cytochrome P450 1A1 - Mesocricetus auratus (Golden hamster)| Length = 524 Score = 85.1 bits (209), Expect = 9e-16 Identities = 90/428 (21%), Positives = 164/428 (38%), Gaps = 17/428 (3%) Frame = +3 Query: 318 PHF--LKWRAQYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHF---PKNDAHPNXXXX 482 PH K QYG+ G+ P + + + +RQ L + F P + Sbjct: 63 PHLSLTKLSKQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDFYSFTLITNG 122 Query: 483 XXXXXXXXXXXDWVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQ 662 W RR+ A I + SC + + E + +++ Sbjct: 123 KSMTFNPDCGPVWAARRRLAQDALKSFSIALDPASASSCYLEEYVIKEADYLISKFQKLM 182 Query: 663 VEF-----DKSVQELTADIISHTAFGSSYKLGMEAFYA----QKELQAIAISSLLNVQIP 815 E D+ + ++I FG Y + + E + S IP Sbjct: 183 AEVGHFDPDRYLVVSVTNVICAMCFGQRYDHDDQELLSIVNLSNEFGKVTGSGYPPDFIP 242 Query: 816 GFSYLPTKRNRRKWMLEKKLRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGGKQ 995 YLP L KK S + + + + G+ D+ ++E C + + Sbjct: 243 ILRYLPNSSLDAFKDLNKKFYSFMQKSVKEHYRTFEKGHIRDITDSLIEHCQDKSLD-EN 301 Query: 996 EQLSLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGKGD-P 1172 + LS + +++ F AG++T + ++W++ L P Q +++ E+ +G+ P Sbjct: 302 ANVQLSDDRVINIIVDLFGAGFDTVTTAISWSLMYLVTNPGVQRKIQEELDTVIGRSRRP 361 Query: 1173 SGDNLGKLKEMTMVLHETLRLYGPALF-MQRKTTTDMVVGAITIPKEHAIVIGAPFMHRD 1349 + +L + + ET R F + TT D + IPK H + + ++ + Sbjct: 362 RLCDRSQLPYLEAFILETFRHSSFLPFTIPHSTTRDTSLCGFYIPKGHCVFVNQWQINHN 421 Query: 1350 KKVWGEDADQFNPMRFANGVARAAKVPHALLA-FSIGPRACIGQNFAMLEAKSVMATVLQ 1526 +++WG D ++F P RF KV + F +G R CIG+ LE +A +LQ Sbjct: 422 QELWG-DPNKFRPERFLTSSGTLDKVLSGKVTLFGLGKRKCIGETIGRLEVFLFLAILLQ 480 Query: 1527 KFSFALSP 1550 + F +SP Sbjct: 481 QIEFTVSP 488
>Q6GUR1:CP1A1_MACMU Cytochrome P450 1A1 - Macaca mulatta (Rhesus macaque)| Length = 512 Score = 85.1 bits (209), Expect = 9e-16 Identities = 64/250 (25%), Positives = 114/250 (45%), Gaps = 3/250 (1%) Frame = +3 Query: 810 IPGFSYLPTKRNRRKWMLEKKLRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGG 989 IP YLP + L +K S + ++I + G+ D+ ++E C E +Q Sbjct: 237 IPILRYLPNRSLNGFKDLNEKFHSFMQKMIKEHYKTFEKGHIRDITDSLIEHCQE-KQLD 295 Query: 990 KQEQLSLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGKG- 1166 + + LS E+I++ F AG++T + ++W++ L P Q +++ E+ +G+ Sbjct: 296 ENANIQLSDEKIVNVVLDLFGAGFDTVTTAISWSLMYLVTNPRVQRKIQEELDTVIGRSR 355 Query: 1167 DPSGDNLGKLKEMTMVLHETLRLYGPALF-MQRKTTTDMVVGAITIPKEHAIVIGAPFMH 1343 P + L M + ET R F + TT D + IPK + + ++ Sbjct: 356 RPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQIN 415 Query: 1344 RDKKVWGEDADQFNPMRFANGVARAAKV-PHALLAFSIGPRACIGQNFAMLEAKSVMATV 1520 D+K+W + +F P RF KV ++ F +G R CIG+ A E +A + Sbjct: 416 HDQKLW-VNPSEFLPERFITPDGAIDKVLSEKVILFGLGKRKCIGETIARWEVFLFLAIL 474 Query: 1521 LQKFSFALSP 1550 LQ+ F++ P Sbjct: 475 LQRVEFSVPP 484
>Q964Q7:CP6D3_MUSDO Cytochrome P450 6d3 - Musca domestica (House fly)| Length = 520 Score = 84.7 bits (208), Expect = 1e-15 Identities = 105/449 (23%), Positives = 182/449 (40%), Gaps = 33/449 (7%) Frame = +3 Query: 330 KWRAQYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHFPKNDAHPNXXXXXXXXXXXXX 509 K++ Q +LF+ KP + + D EL RQIL+S F + + Sbjct: 61 KFQEQVVGIYLFF---KPALLIRDAELARQILTSDFNSFHDRGIYVDEKNDPMSANLFAL 117 Query: 510 XXD-WVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQ 686 W R + P+F+ K+K M +T+ Q + + KS+ Sbjct: 118 EGQSWRTLRMKLTPSFSSGKLKGMFETVDDVGNKLLEYLNNQLKDGQTHVLDI---KSIL 174 Query: 687 ELTA-DIISHTAFGSSYK-----------LGMEAFYAQKELQAIAISSLLNVQIPGFSYL 830 A DII FG L +F + + +L N P + L Sbjct: 175 TTYAIDIIGSVIFGLEIDSFTNPDNEFRVLSDRSFDNESRSFLSKLQNLTNFVCPPIAKL 234 Query: 831 PTKRNRRKWMLEKKLRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGGKQEQL-- 1004 T+ ++ ++ + LR + R I R + + DLL L+++ + + L Sbjct: 235 LTRLGTKEPVVYR-LRDIVKRTIEFR--EENNVVRKDLLHLLIQLRNTGKISDDNDNLWN 291 Query: 1005 ----------SLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEV--- 1145 ++S++ I F+ AG ETT+ ++T++ L++ PE ++ + EV Sbjct: 292 KVESTATNLKAMSIDMIASNSFLFYIAGSETTASSTSFTIYELAMNPEALKKAQNEVDEC 351 Query: 1146 LREVG---KGDPSGDNLGKLKEMTMVLHETLRLYGPALFMQRKTTTDMVV--GAITIPKE 1310 L++ G G + + + +K + + + ET R Y F+ R+ T D V TI K+ Sbjct: 352 LKKHGIKPDGRITYEAIQDMKYLDLCVKETTRKYPGLPFLNRQCTQDFKVPNSKFTIKKD 411 Query: 1311 HAIVIGAPFMHRDKKVWGEDADQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAM 1490 ++I +HRD K + E + P RFA+ A + F GPR CI Q + Sbjct: 412 TNVIISLLGLHRDAKYFPEPL-AYKPERFADETKDYDAA--AYMPFGEGPRHCIAQRMGV 468 Query: 1491 LEAKSVMATVLQKFSFALSPSYVHAPADF 1577 + K +A +L F+ P H A+F Sbjct: 469 MNTKVALAKILANFNIEPMP---HKEAEF 494
>P24465:C71A1_PERAE Cytochrome P450 71A1 - Persea americana (Avocado)| Length = 471 Score = 84.7 bits (208), Expect = 1e-15 Identities = 82/331 (24%), Positives = 153/331 (46%), Gaps = 14/331 (4%) Frame = +3 Query: 594 SCAQSTFGVFEEQASKNTNKEIQVEFDKSVQELTADIISHTAFGSSYKLGMEAFYAQKEL 773 S + G+ E+ S++ + V + + L++ I+ AFG Y+ E +L Sbjct: 145 SIREEEVGLMMERISQSCSTGEAVNLSELLLLLSSGTITRVAFGKKYEGEEERKNKFADL 204 Query: 774 QAIAISSLLNV-----QIPGFSYLP--TKRNRRKWMLEKKLRSTLMRIINSRLASQGSGY 932 A +++L+ P F+++ T + R +L + + +I+ L S+ + Sbjct: 205 -ATELTTLMGAFFVGDYFPSFAWVDVLTGMDARLKRNHGELDAFVDHVIDDHLLSRKANG 263 Query: 933 GN-----DLLGLMLEGCTETEQGGKQEQLSLSMEEILHECKTFFFAGYETTSLLLTWTVF 1097 + DL+ ++L ++ G + L+ + F G +TT++ L W + Sbjct: 264 SDGVEQKDLVDVLLHLQKDSSLG-----VHLNRNNLKAVILDMFSGGTDTTAVTLEWAMA 318 Query: 1098 LLSVYPEWQERLRAEVLREVGK-GDPSGDNLGKLKEMTMVLHETLRLYGPA-LFMQRKTT 1271 L +P+ E+ + EV R VGK ++L +L + +++ ETLRL+ A L + R++T Sbjct: 319 ELIKHPDVMEKAQQEVRRVVGKKAKVEEEDLHQLHYLKLIIKETLRLHPVAPLLVPREST 378 Query: 1272 TDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDADQFNPMRFANGVARAAKVPHALLAFS 1451 D+V+ IP + + I A + RD K W E+A++F P RF N L+ F Sbjct: 379 RDVVIRGYHIPAKTRVFINAWAIGRDPKSW-ENAEEFLPERFVNNSVDFKGQDFQLIPFG 437 Query: 1452 IGPRACIGQNFAMLEAKSVMATVLQKFSFAL 1544 G R C G F + + +A +L F++ L Sbjct: 438 AGRRGCPGIAFGISSVEISLANLLYWFNWEL 468
>P21595:CP56_YEAST Cytochrome P450-DIT2 - Saccharomyces cerevisiae (Baker's yeast)| Length = 489 Score = 84.3 bits (207), Expect = 2e-15 Identities = 62/177 (35%), Positives = 90/177 (50%), Gaps = 9/177 (5%) Frame = +3 Query: 1053 AGYETTSLLLTWTVFLLSVYP-EWQERLRAEVLREVGKGDPSGDNLGKLKEMTMVLHETL 1229 AG+E LL +++LL+ Y EWQE+LR EV G DP G L L + L E + Sbjct: 293 AGHENPQLLFNSSLYLLAKYSNEWQEKLRKEVN---GITDPKG--LADLPLLNAFLFEVV 347 Query: 1230 RLYGP-ALFMQRKTTTDMVVGA-ITIPKEHAIVIGAPFMHRDKKVWGEDADQFNPMRFAN 1403 R+Y P + + R TT +GA I IPK + D K WG AD F P R+ + Sbjct: 348 RMYPPLSTIINRCTTKTCKLGAEIVIPKGVYVGYNNFGTSHDPKTWGTTADDFKPERWGS 407 Query: 1404 GVA------RAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSPSY 1556 + R AK A+ F G RAC+G+ A+ E + +A +L++F ++L P + Sbjct: 408 DIETIRKNWRMAKNRCAVTGFHGGRRACLGEKLALTEMRISLAEMLKQFRWSLDPEW 464
>Q5RE72:CP51A_PONPY Cytochrome P450 51A1 - Pongo pygmaeus (Orangutan)| Length = 503 Score = 84.3 bits (207), Expect = 2e-15 Identities = 81/301 (26%), Positives = 128/301 (42%), Gaps = 6/301 (1%) Frame = +3 Query: 672 DKSVQELTADII----SHTAFGSSYKLGMEAFYAQKELQAIAISSLLNVQIPGFSYLPTK 839 +K+V E +++I SH G + + AQ S +PG+ LP+ Sbjct: 191 EKNVFEALSELIILTASHCLHGKEVRSQLNEKVAQLYADLDGGFSHAAWLLPGWLPLPSF 250 Query: 840 RNRRKWMLEKKLRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGGKQEQLSLSME 1019 R R + ++++ + I R SQ +D+L +L+ T + G+ L+ + Sbjct: 251 RRRDR--AHREIKDIFYKAIQKRRQSQEKI--DDILQTLLDA---TYKDGRP----LTDD 299 Query: 1020 EILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGKGDP--SGDNLGK 1193 E+ AG T+S W F L+ QE+ E G+ P + D L Sbjct: 300 EVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQEKCYLEQKTVCGENLPPLTYDQLKD 359 Query: 1194 LKEMTMVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDA 1373 L + + ETLRL P + M R T V TIP H + + R K W E Sbjct: 360 LNLLDRCIKETLRLRPPIMIMMRMARTPQTVAGYTIPPGHQVCVSPTVNQRLKDSWVERL 419 Query: 1374 DQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSPS 1553 D FNP R+ A+ A + F G CIG+NFA ++ K++ +T+L+ + F L Sbjct: 420 D-FNPDRYLQD-NPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEFDLIDG 477 Query: 1554 Y 1556 Y Sbjct: 478 Y 478
>O54749:CP2J5_MOUSE Cytochrome P450 2J5 - Mus musculus (Mouse)| Length = 501 Score = 84.3 bits (207), Expect = 2e-15 Identities = 59/181 (32%), Positives = 85/181 (46%), Gaps = 3/181 (1%) Frame = +3 Query: 1005 SLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVG-KGDPSGD 1181 S + E ++ F G ETTS L W + +S YPE QE ++AE+ R +G K S Sbjct: 294 SFNEENLISTTLDLFLGGTETTSSTLRWALLYMSSYPEIQENVQAEIDRVIGHKRQVSLS 353 Query: 1182 NLGKLKEMTMVLHETLRLYG-PALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKV 1358 + + V+HE R+ L R+ T D +PK I+ +HRD K Sbjct: 354 DRESMPYTNAVIHEVQRMGNIVPLNSSREVTVDTKFNGFHLPKGTMILTNLTALHRDPKE 413 Query: 1359 WGEDADQFNPMRF-ANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFS 1535 W + FNP F NG K + L FS+G RAC+G+ A E + ++QKF+ Sbjct: 414 WA-TPEVFNPEHFLENG---QFKKRESFLPFSMGKRACLGEQLAKSELFIFFSALMQKFT 469 Query: 1536 F 1538 F Sbjct: 470 F 470
>Q06367:CP1A1_CAVPO Cytochrome P450 1A1 - Cavia porcellus (Guinea pig)| Length = 516 Score = 84.3 bits (207), Expect = 2e-15 Identities = 93/428 (21%), Positives = 168/428 (39%), Gaps = 17/428 (3%) Frame = +3 Query: 318 PHFLKWR--AQYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHF---PKNDAHPNXXXX 482 PH R A+YG+ G+ P + + + +RQ L + F P + Sbjct: 55 PHLALTRLSARYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYSFTFISDG 114 Query: 483 XXXXXXXXXXXDWVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQ 662 W RR+ A + + ++ SC E + +E+ Sbjct: 115 QSMTFNPDSGPVWAARRRLAQSALKSFSVASDPASVSSCYLEEHVKKEAEYLIKKFQELM 174 Query: 663 V---EFD--KSVQELTADIISHTAFGSSYKLG----MEAFYAQKELQAIAISSLLNVQIP 815 FD + V A++IS FG Y +E E + S + IP Sbjct: 175 AGPGHFDPYRYVVVSVANVISAICFGQRYSHDDQQLLELIDLNNEFGEVTGSGNPSDFIP 234 Query: 816 GFSYLPTKRNRRKWMLEKKLRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGGKQ 995 YLP+ L ++ + ++I + G+ D+ ++E C + + K Sbjct: 235 ILRYLPSATMDTFKDLNRRFSVFIQKMIKEHYKTFEKGHIRDITDSLIEHCQDRKLD-KN 293 Query: 996 EQLSLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGK-GDP 1172 + +S ++I+ F AG++T + ++W++ L + P Q++++ E+ +G+ P Sbjct: 294 ANIQISDQKIIGIVLDLFGAGFDTITTAISWSLLYLVMNPRIQKKIQEELDTVIGRERQP 353 Query: 1173 SGDNLGKLKEMTMVLHETLRLYGPALF-MQRKTTTDMVVGAITIPKEHAIVIGAPFMHRD 1349 + KL M + E R F + TT D + IPK I + ++ D Sbjct: 354 QLADRPKLPYMEAFISEVFRYSSFMPFTIPHSTTKDTSLNGFYIPKGCCIFVNQWQINHD 413 Query: 1350 KKVWGEDADQFNPMRFANGVARAAK-VPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQ 1526 +K+WG D F P RF + K + + F +G R C+G+ E +A +LQ Sbjct: 414 QKLWG-DPSVFRPERFLSPDGTVDKALSEKVTIFGLGKRRCLGEVIGRWEVFLFLAILLQ 472 Query: 1527 KFSFALSP 1550 + F+ SP Sbjct: 473 QLEFSTSP 480
>Q4V8D1:CP2U1_RAT Cytochrome P450 2U1 - Rattus norvegicus (Rat)| Length = 530 Score = 84.0 bits (206), Expect = 2e-15 Identities = 94/431 (21%), Positives = 172/431 (39%), Gaps = 14/431 (3%) Frame = +3 Query: 294 HDYLHRVAPHFLKWRAQYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHFPKNDAHP-- 467 H YL R+A YG F F+ G + + + D++ VR+ L ++ F P Sbjct: 90 HVYLARLA-------RVYGNIFSFFIGHRLVVVLSDFQSVREALVQQAEVFSDRPRMPLI 142 Query: 468 NXXXXXXXXXXXXXXXDWVRHRRVIDPA---FAMDKIKAMTKTMVSCAQSTFGVFEEQAS 638 + W + RR F + K+ + + A +A Sbjct: 143 SILTKEKGIVFAHYGPIWKQQRRFSHSTLRHFGLGKLSLEPRIIEEFAYV-------KAE 195 Query: 639 KNTNKEIQVEFDKSVQELTADIISHTAFGSSYKLGMEAFYAQKELQAIAISSLLNVQI-- 812 + E + ++II FG + + F + + + L+ Q+ Sbjct: 196 MQKHGEAPFSPFPVISNAVSNIICSLCFGQRFDYTNKEFKKVLDFMSRGLEICLHSQLFL 255 Query: 813 ----PGFSYLPTKRNRRKWMLEKKLRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETE 980 P F YLP + +E+ + L II S + D + + L E Sbjct: 256 INLCPWFYYLPFGPFKELRQIERDITCFLKNIIKEHQESLDANNPQDFIDMYL--LHTQE 313 Query: 981 QGGKQEQLSLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVG 1160 + K + + + + + F AG +TT+ L W + +S+ P Q+++ E+ R +G Sbjct: 314 EKDKCKGTNFDEDYLFYIIGDLFIAGTDTTTNSLLWCLLYMSLNPGVQKKVHEEIERVIG 373 Query: 1161 KGD-PSGDNLGKLK--EMTMVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGA 1331 + PS + ++ E T++ + L + P L + T+ V+ +IPK ++ Sbjct: 374 RDRAPSLTDKAQMPYTEATIMEVQRLSMVVP-LAIPHMTSEKTVLQGYSIPKGTVVLPNL 432 Query: 1332 PFMHRDKKVWGEDADQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVM 1511 +HRD +W E D F P RF + + K + F IG R C+G+ A +E + Sbjct: 433 WSIHRDPVIW-EKPDDFCPHRFLDDQGQLLK-RETFIPFGIGKRVCMGEQLAKMELFLMF 490 Query: 1512 ATVLQKFSFAL 1544 +++Q F+FAL Sbjct: 491 VSLMQSFTFAL 501
>P56591:CP1A1_SHEEP Cytochrome P450 1A1 - Ovis aries (Sheep)| Length = 519 Score = 84.0 bits (206), Expect = 2e-15 Identities = 70/292 (23%), Positives = 128/292 (43%), Gaps = 7/292 (2%) Frame = +3 Query: 696 ADIISHTAFGSSYKLGMEAFYA----QKELQAIAISSLLNVQIPGFSYLPTKRNRRKWML 863 A++I FG Y + F + E I S IP YLP L Sbjct: 202 ANVICAICFGRRYDHDDQEFLSLINLSNEFGEITASGNPADFIPVLRYLPNTALDLFKDL 261 Query: 864 EKKLRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGGKQEQLSLSMEEILHECKT 1043 ++ + +I+ + G+ D+ ++E C + ++ + + LS E+I++ Sbjct: 262 NRRFYVFVQKIVKEHYKTFEKGHIRDITDSLIEHCQD-KRLDENANIQLSDEKIINVVMD 320 Query: 1044 FFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGKGD-PSGDNLGKLKEMTMVLH 1220 F AG++T + ++W++ L P Q++++ E+ +G+ P + +L + + Sbjct: 321 LFGAGFDTVTTAISWSLLYLVTSPRVQKKIQEELDTVIGRARWPQLSDRPQLPYLEAFIL 380 Query: 1221 ETLRLYGPALF-MQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDADQFNPMRF 1397 ET R F + TT D + IPK + + ++ D+K+W ED +F P RF Sbjct: 381 ETFRHSSFVPFTIPHSTTRDTNLNGFYIPKGXCVFVNQWQINHDQKLW-EDPSEFRPERF 439 Query: 1398 ANGVARAAKV-PHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSP 1550 KV ++ F +G R CIG+ A LE +A +L + F ++P Sbjct: 440 LTTDGTVNKVLSEKVIIFGLGKRQCIGEIIARLEVFLFLAILLHQVEFHVTP 491
>Q9LTM6:C71BH_ARATH Cytochrome P450 71B17 - Arabidopsis thaliana (Mouse-ear cress)| Length = 502 Score = 84.0 bits (206), Expect = 2e-15 Identities = 86/369 (23%), Positives = 159/369 (43%), Gaps = 16/369 (4%) Frame = +3 Query: 516 DWVRHRR-VIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQEL 692 +W RR ++ F K+++ + + F V ++ S++ + V+ K++ L Sbjct: 121 EWKERRRFLVGELFCSKKLQSFI--YIKEVECNFLV--KKLSESAVDQSPVDLSKTLFWL 176 Query: 693 TADIISHTAFGSSY---------KLGMEAFYAQKELQAIAISSLLNVQIPGFSYLP---T 836 A I+ AFG S+ K+ F + + S I G +L + Sbjct: 177 AASILFRVAFGQSFHESEFTDTDKIDELVFETETAQGSFTCSDFF--PIAGLGWLVDWIS 234 Query: 837 KRNRRKWMLEKKLRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGGKQEQLSLSM 1016 +++R + KL + L +I+ S D++ +ML+ + GK + L L++ Sbjct: 235 GQHKRLNDVFLKLDALLQHVIDDHSNPGRSKDHKDIVDVMLD---VMHKQGKDDSLRLTI 291 Query: 1017 EEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGKGDP--SGDNLG 1190 + I AG +T +L + WT+ L+ PE ++++ E+ +G + ++L Sbjct: 292 DHIKGLLTNIIIAGIDTGALTMIWTMTELARNPEIMKKVQGEIRDRLGNNRERITKEDLD 351 Query: 1191 KLKEMTMVLHETLRLYGPA-LFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGE 1367 K+ + +V+ ET RL+ A L + R+T + V IP + I++ A + RD K+W Sbjct: 352 KVPFLNLVIKETFRLHPVAPLLLPRETMAHVKVQGYDIPPKRRILVNAWAIGRDPKLW-T 410 Query: 1368 DADQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALS 1547 D ++F P RF + LL F G R C G M + + +L F + L Sbjct: 411 DPEEFKPERFIDSPVDYRGQHFELLPFGSGRRICPGMAMGMATLELGLLNLLYFFDWKLP 470 Query: 1548 PSYVHAPAD 1574 H D Sbjct: 471 DGMSHKDID 479
>Q9V769:C6A22_DROME Cytochrome P450 6a22 - Drosophila melanogaster (Fruit fly)| Length = 499 Score = 84.0 bits (206), Expect = 2e-15 Identities = 110/467 (23%), Positives = 195/467 (41%), Gaps = 14/467 (2%) Frame = +3 Query: 192 QGIHGPPYRFLRGSNEEVRRMKAETAHVVLHVRDHDYLHRVAPHFLKWRAQYGEPFL-FW 368 +GI P RF G+ E R+ K ++ V P + K++ G PF F+ Sbjct: 29 RGIGSEPARFPVGNMEGFRKNK-------------HFIDIVTPIYEKFKGN-GAPFAGFF 74 Query: 369 FGAKPRICVFDYELVRQILSSKSGHFPKNDAHPNXXXXXXXXXXXXXXXD-WVRHRRVID 545 +P + V D EL +QIL +F + N W R+ + Sbjct: 75 MMLRPVVLVTDLELAKQILIQDFANFEDRGMYHNERDDPLTGHLFRIDGPKWRPLRQKMS 134 Query: 546 PAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQELTADIISHTAFG 725 P F K+K M T+ + V E A N I +E + T+D+I AFG Sbjct: 135 PTFTSAKMKYMFPTVCEVGEELTQVCGELAD-NAMCGI-LEIGDLMARYTSDVIGRCAFG 192 Query: 726 SSYK--LGMEAFYAQKELQAIAISSLLNVQIPGF--SYLPTKRNRRKWMLEKKLRSTLMR 893 EA +A +A + + + GF S+ R R + + + + Sbjct: 193 VECNGLRNPEAEFAIMGRRAFSERRHCKL-VDGFIESFPEVARFLRMRQIHQDITDFYVG 251 Query: 894 IINSRLASQGSG--YGNDLLGLMLEGCTETEQGGKQEQLSLSMEEILHECKTFFFAGYET 1067 I+ + + +D + L++E +++ L++EE+ + FF AG++T Sbjct: 252 IVRETVKQREEQGIVRSDFMNLLIE---------MKQRGELTIEEMAAQAFIFFAAGFDT 302 Query: 1068 TSLLLTWTVFLLSVYPEWQERLRAEVLR--EVGKGDPSGDNLGKLKEMTMVLHETLRLYG 1241 ++ L + ++ L+ P Q +LR E+ + + G+ + D++ +L+ M +V+ ETLR Y Sbjct: 303 SASTLGFALYELAKQPALQAKLREEIDQALRLHNGEFTYDSMQELRYMELVIAETLRKY- 361 Query: 1242 PALFMQRKTTTDMVVGA----ITIPKEHAIVIGAPFMHRDKKVWGEDADQFNPMRFANGV 1409 P L + + + I ++I +H D ++ E +F P RF Sbjct: 362 PILPQLTRISRHLYAAKGDRHFYIEPGQMLLIPVYGIHHDPALYPEP-HKFIPERFLADQ 420 Query: 1410 ARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSP 1550 A + A L F GPR CIG F ++ + ++L+ F F++ P Sbjct: 421 L-AQRPTAAWLPFGDGPRNCIGMRFGKMQTTIGLVSLLRNFHFSVCP 466
>P82711:C6A19_DROME Probable cytochrome P450 6a19 - Drosophila melanogaster (Fruit fly)| Length = 503 Score = 84.0 bits (206), Expect = 2e-15 Identities = 96/422 (22%), Positives = 175/422 (41%), Gaps = 13/422 (3%) Frame = +3 Query: 324 FLKWRAQYGEPFL-FWFGAKPRICVFDYELVRQILSSKSGHFPKNDAHPNXXXXXXXXXX 500 +LK+R Q PF F+ A I + D + V+ +L F + N Sbjct: 60 YLKFRKQTDGPFAGFYLYAMKYIVITDVDFVKTVLIRDFDKFHDRGVYHNEKDDPLTNNL 119 Query: 501 XXXXXD-WVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDK 677 W R+ + F K+K+M T+++ V +E+ S ++ +E Sbjct: 120 ATIEGQKWKNLRQKLTHTFTSAKMKSMFSTVLNVGDEMIRVVDEKISSSSQT---LEVTD 176 Query: 678 SVQELTADIISHTAFGSSYKL--GMEAFYAQKELQAIAISS---LLNVQIPGFSYLPTKR 842 V T+D+I AFG +A + Q A+ L+++ I G L K Sbjct: 177 IVSRFTSDVIGICAFGLKCNSLRDPKAEFVQMGYSALRERRHGWLVDLLIFGMPKLAVKL 236 Query: 843 NRRKWMLEKKLRSTLMRIINSRL--ASQGSGYGNDLLGLMLEGCTETEQGGKQEQLSLSM 1016 + L ++ M+I+ + + ND + +++ + ++G K+ L+ Sbjct: 237 GFQ--FLLPSVQKFYMKIVQDTIDYRMKRKVTRNDFMDTLIDMKQQYDKGDKEN--GLAF 292 Query: 1017 EEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEV--LREVGKGDPSGDNLG 1190 E+ + FF AG+E S + +T++ L+ + Q++LRAE+ + E G D++ Sbjct: 293 NEVAAQAFVFFLAGFEAGSTTMGFTLYELACNQDVQDKLRAEIDSVLERYNGKLEYDSMQ 352 Query: 1191 KLKEMTMVLHETLRLYGPALFMQRKTTTDMVVG--AITIPKEHAIVIGAPFMHRDKKVWG 1364 L M V++E+LR + + R T I +++ +H D + + Sbjct: 353 DLFYMEKVINESLRKHPVVAHLARIATKPYQHSNPKYFIEAGTGVLVSTLGIHHDPEFYP 412 Query: 1365 EDADQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFAL 1544 E ++F P RF + + A L F GPR CIG F ++ +A ++ F F L Sbjct: 413 E-PEKFIPERFDEEQVK-KRPTCAFLPFGAGPRNCIGLRFGRMQVIIGLALLIHNFRFEL 470 Query: 1545 SP 1550 P Sbjct: 471 HP 472
>Q8W4T9:T13H_TAXCU Taxane 13-alpha-hydroxylase - Taxus cuspidata (Japanese yew)| Length = 485 Score = 83.6 bits (205), Expect = 3e-15 Identities = 92/346 (26%), Positives = 151/346 (43%), Gaps = 10/346 (2%) Frame = +3 Query: 603 QSTFGVFEEQASKNTNKEIQVEFDKSVQELTADIISHTAFGSSYKLGMEAFYAQKE--LQ 776 Q+ F ++ N++ + + + +V L D++ A + + E Q L+ Sbjct: 149 QNHFAKMSSGIQRHINEKWKGKDEATVLPLVKDLVFSVASRLFFGITEEHLQEQLHNLLE 208 Query: 777 AIAISSL-LNVQIPGFSYLPTKRNRRKWMLEKKLRSTLMRIINSR---LASQGSGYGNDL 944 I + S + + IPGFSY + R L + +I R L + + DL Sbjct: 209 VILVGSFSVPLNIPGFSYHKAIQARAT------LADIMTHLIEKRRNELRAGTASENQDL 262 Query: 945 LGLMLEGCTETEQGGKQEQLSLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQ 1124 L ++L T T++ G SL+ +EIL Y++T+ LT + +L+ +PE Sbjct: 263 LSVLL---TFTDERGN----SLADKEILDNFSMLLHGSYDSTNSPLTMLIKVLASHPESY 315 Query: 1125 ERLRAE---VLREVGKGDP-SGDNLGKLKEMTMVLHETLRLYGPALFMQRKTTTDMVVGA 1292 E++ E +L +G+ + +L ++K V+ ETLR+Y P RK TD+ Sbjct: 316 EKVAQEQFGILSTKMEGEEIAWKDLKEMKYSWQVVQETLRMYPPIFGTFRKAITDIHYNG 375 Query: 1293 ITIPKEHAIVIGAPFMHRDKKVWGEDADQFNPMRFANGVARAAKVPHALLAFSIGPRACI 1472 TIPK + + + + K+ + +DADQF P RF P+ L F G R C Sbjct: 376 YTIPKGWKL-LWTTYSTQTKEEYFKDADQFKPSRFEEEGKHV--TPYTYLPFGGGMRVCP 432 Query: 1473 GQNFAMLEAKSVMATVLQKFSFALSPSYVHAPADFLTLRPKFGLPV 1610 G FA +E L F A S P + L+ +P LPV Sbjct: 433 GWEFAKMET----LLFLHHFVKAFSGLKAIDPNEKLSGKPLPPLPV 474
>Q92110:CP1A1_ONCMY Cytochrome P450 1A1 - Oncorhynchus mykiss (Rainbow trout) (Salmo| gairdneri) Length = 522 Score = 83.6 bits (205), Expect = 3e-15 Identities = 71/274 (25%), Positives = 119/274 (43%), Gaps = 4/274 (1%) Frame = +3 Query: 810 IPGFSYLPTKRNRRKWMLEKKLRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGG 989 IP YLP + +R + + + + +I++ S D+ +++ C E + Sbjct: 242 IPILRYLPNRTMKRFMDINDRFNNFVQKIVSEHYESYDKDNIRDITDSLIDHC-EDRKLD 300 Query: 990 KQEQLSLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGK-G 1166 + + +S E+I+ F AG++T S L+W V L YPE QERL E+ +VG Sbjct: 301 ENANIQVSDEKIVGIVNDLFGAGFDTISTALSWAVVYLVAYPEIQERLHQELKEKVGMIR 360 Query: 1167 DPSGDNLGKLKEMTMVLHETLRLYGPALF-MQRKTTTDMVVGAITIPKEHAIVIGAPFMH 1343 P + L + + E R F + T D + IPK+ + I ++ Sbjct: 361 TPRLSDKINLPLLEAFILEIFRHSSFLPFTIPHCTIKDTSLNGYFIPKDTCVFINQWQVN 420 Query: 1344 RDKKVWGEDADQFNPMRF--ANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMAT 1517 D ++W E + FNP RF A+G +L F + R CIG+ E +A Sbjct: 421 HDPELWKEPS-SFNPDRFLSADGTELNKLEGEKVLVFGMDKRRCIGEAIGRNEVYLFLAI 479 Query: 1518 VLQKFSFALSPSYVHAPADFLTLRPKFGLPVVMK 1619 +LQ+ F P + L + P++GL + K Sbjct: 480 LLQRLRFQEKPGHP------LDMTPEYGLTMKHK 507
>Q92045:CP11A_DASAM Cytochrome P450 11A1, mitochondrial precursor - Dasyatis americana| (Southern stingray) Length = 514 Score = 83.6 bits (205), Expect = 3e-15 Identities = 80/365 (21%), Positives = 155/365 (42%), Gaps = 20/365 (5%) Frame = +3 Query: 516 DWVRHRRVIDPA-FAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQEL 692 +W R R +++ + FA I+ + + ++ K+ + + + + +L Sbjct: 147 NWKRTRLILNNSIFAQSSIQRLVPLFNEVVLDFVSMVHKEVEKSRSDYWKTDLTNDLFKL 206 Query: 693 TADIISHTAFGSSYKLGMEAFYAQKELQAIAISSLLNVQIPGFSYLPTKRNRRKWMLEKK 872 ++I + +G L + + +I+++ + P Y+P Sbjct: 207 ALEVICYILYGERLDLLQRKYNKAPQKFIDSIATMFH-STPIMLYVPP------------ 253 Query: 873 LRSTLMRIINSRLASQGSGYGNDLLG----LMLEGCTETEQGGKQE------------QL 1004 +L++ INS++ Q G +++ + + + +QG K E Q Sbjct: 254 ---SLLKSINSKIWQQHVGSWDNIFEHADTYLKKAYRQFQQGSKNEHAFPGVLTELLLQG 310 Query: 1005 SLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGKGDPSGDN 1184 +L E+I +TTS + W ++ L+ +P Q+ +R+E++ K + GD Sbjct: 311 ALPFEDIRASIIDVMSGAIDTTSTTVHWMMYELAKHPHIQKNVRSEIMEAHQKTE--GDP 368 Query: 1185 LGKLKEMTM---VLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKK 1355 + LK + + V+ ETLRLY A+ +QR D V+ IP + +G M R+ K Sbjct: 369 VKMLKSVPLLKCVVKETLRLYPVAISIQRYLNEDTVLQNYHIPAGTLVQLGLYAMGRNPK 428 Query: 1356 VWGEDADQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFS 1535 ++ ++ +Q+NP R+ G L F GPR CIG+ A + +M +LQ F Sbjct: 429 IF-KNPEQYNPERWLKG----EDTHFRHLGFGFGPRQCIGRRIAETQMVLLMIHMLQNFK 483 Query: 1536 FALSP 1550 P Sbjct: 484 IETDP 488
>Q0IIF9:CP2U1_BOVIN Cytochrome P450 2U1 - Bos taurus (Bovine)| Length = 543 Score = 83.2 bits (204), Expect = 3e-15 Identities = 72/296 (24%), Positives = 120/296 (40%), Gaps = 8/296 (2%) Frame = +3 Query: 681 VQELTADIISHTAFGSSYKLGMEAFYAQKELQAIAISSLLNVQI------PGFSYLPTKR 842 V ++II FG + F + A+ LN Q+ YLP Sbjct: 224 VNNAVSNIICSLCFGRRFDYTNSEFKQMLNFMSRALEVCLNTQLLLVNICSWLYYLPFGP 283 Query: 843 NRRKWMLEKKLRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGGKQEQLSLSMEE 1022 + +EK L L +II S D + + L E ++ + Sbjct: 284 FKELRQIEKDLTLFLKKIIKDHRESLDVENPQDFIDMYLLHVEEEKKNNSNS--GFDEDY 341 Query: 1023 ILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGKG-DPSGDNLGKLK 1199 + + F AG +TT+ L W + +S++P QE++ E+ R +G PS + ++ Sbjct: 342 LFYIIGDLFIAGTDTTTNSLLWCLLYMSLHPNIQEKIHEEIARVIGADRAPSLTDKAQMP 401 Query: 1200 EMTMVLHETLRLYGPA-LFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDAD 1376 + E RL L + T+ V+ TIPK I+ +HRD +W E + Sbjct: 402 YTEATIMEVQRLSTVVPLSIPHMTSEKTVLQGFTIPKGTIILPNLWSVHRDPAIW-EKPN 460 Query: 1377 QFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFAL 1544 F P RF + + K + F IG R C+G+ A +E + +++Q F+F L Sbjct: 461 DFYPDRFLDDQGQLIK-KETFIPFGIGKRVCMGEQLAKMELFLMFVSLMQSFTFVL 515
>P08686:CP21A_HUMAN Cytochrome P450 21 - Homo sapiens (Human)| Length = 494 Score = 83.2 bits (204), Expect = 3e-15 Identities = 102/380 (26%), Positives = 161/380 (42%), Gaps = 12/380 (3%) Frame = +3 Query: 519 WVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQELTA 698 W H+++ A + +M + Q F E+ + +E + S+ LT Sbjct: 116 WKAHKKLTRSALLLGIRDSMEPVVEQLTQE----FCERMRAQPGTPVAIEEEFSL--LTC 169 Query: 699 DIISHTAFGSSYKLG--MEAFYA--QKELQAIAISSLLNVQ-IPGFSYLPTKRNRR-KWM 860 II + FG K M A+Y Q+ L+ + S+ V IP + P RR K Sbjct: 170 SIICYLTFGDKIKDDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLRFFPNPGLRRLKQA 229 Query: 861 LEKKLRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGGKQEQLSLSMEEILHECK 1040 +EK+ M++ + S +G D++ ML+G + QL +E +H Sbjct: 230 IEKRDHIVEMQLRQHK-ESLVAGQWRDMMDYMLQGVAQPSMEEGSGQL---LEGHVHMAA 285 Query: 1041 T-FFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGKGDPSG----DNLGKLKEM 1205 G ETT+ L+W V L +PE Q+RL+ E+ E+G G S + +L + Sbjct: 286 VDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLL 345 Query: 1206 TMVLHETLRLYGPA-LFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDADQF 1382 + E LRL L + +TT + IP+ I+ H D+ VW E +F Sbjct: 346 NATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVW-ERPHEF 404 Query: 1383 NPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSPSYVH 1562 P RF + LAF G R C+G+ A LE V+ +LQ +F L PS Sbjct: 405 WPDRFLEPGKNS-----RALAFGCGARVCLGEPLARLELFVVLTRLLQ--AFTLLPSGDA 457 Query: 1563 APADFLTLRPKFGLPVVMKL 1622 P +L+P V++K+ Sbjct: 458 LP----SLQPLPHCSVILKM 473
>Q92039:CP1A1_CHACA Cytochrome P450 1A1 - Chaetodon capistratus (Four-eye butterflyfish)| Length = 521 Score = 83.2 bits (204), Expect = 3e-15 Identities = 66/269 (24%), Positives = 120/269 (44%), Gaps = 4/269 (1%) Frame = +3 Query: 825 YLPTKRNRRKWMLEKKLRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGGKQEQL 1004 +LP+ ++ + + + +I+ A+ D+ +++ C E + + + Sbjct: 247 FLPSTTMKKFMTINADFNTFVKKIVGEHYATFDKNNIRDITDSLIDHC-EDRKLDENCNV 305 Query: 1005 SLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVG-KGDPSGD 1181 +S E+I+ F AG++T S L+W+V L YP+ QERL E+ VG P Sbjct: 306 QMSDEKIVGIVNDLFGAGFDTVSTALSWSVMYLVAYPDIQERLFQEIKDNVGLDRTPLLS 365 Query: 1182 NLGKLKEMTMVLHETLRLYGPALF-MQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKV 1358 + K+ + + E R F + + D + IPK+ + I ++RD ++ Sbjct: 366 DRSKVPYLEAFILELFRHSSFLPFTIPHCSAKDTSLNGYFIPKDTCVFINQWQINRDPEL 425 Query: 1359 WGEDADQFNPMRF--ANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKF 1532 W +D FNP RF NG + ++ F +G R CIG+ A E +A ++Q+ Sbjct: 426 W-KDPSSFNPDRFLSCNGTEVNKQEGEKVMVFGMGKRRCIGEVIARNEVYRGLAILIQRL 484 Query: 1533 SFALSPSYVHAPADFLTLRPKFGLPVVMK 1619 F P + L + P++GL + K Sbjct: 485 QFH------EMPGELLDMTPEYGLTMKHK 507
>O65784:C71B5_ARATH Cytochrome P450 71B5 - Arabidopsis thaliana (Mouse-ear cress)| Length = 498 Score = 83.2 bits (204), Expect = 3e-15 Identities = 94/438 (21%), Positives = 179/438 (40%), Gaps = 21/438 (4%) Frame = +3 Query: 294 HDYLHRVAPHFLKWRAQYGEPFLFWFGAKPRICVFDYELVRQILSS---KSGHFPKNDAH 464 H LH+++ +YG L FG P I V E ++L + ++ PK Sbjct: 49 HKSLHKISQ-------EYGPVMLLHFGVVPVIIVSSKEGAEEVLKTHDLETCSRPKTVGS 101 Query: 465 PNXXXXXXXXXXXXXXXDWVRHRRV-IDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASK 641 +W R++ + F+ K+K+ +Q + A + Sbjct: 102 GLFTYNFKDIGFAPYGENWREMRKIAVSELFSQKKLKSFRYIREDESQLLVRKVSKSALE 161 Query: 642 NTNKEIQVEFDKSVQELTADIISHTAFGSSYKLGMEAFYAQKELQAIAISSLLNVQIPGF 821 + + K + A II +FG ++ F + ++ + + S N+ F Sbjct: 162 TPTSSVNLR--KVIFTFAASIICRLSFGQNFC----DFVDMETVEELVLESETNLGSLAF 215 Query: 822 S-YLPTKRNRRKWMLEK-------------KLRSTLMRIINSRLASQGSGYGNDLLGLML 959 + +LP W++++ KL + +I+ L S +D++ +ML Sbjct: 216 ADFLPAG-----WIIDRISGQHSTVMKAFSKLTNFFELVIDDHLKSGKIEDHSDIISVML 270 Query: 960 EGCTETEQGGKQEQLSLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRA 1139 + + + G + ++ ++ + F AG S+ + WT+ LS +P +L+ Sbjct: 271 DMINKPTEVGSYKVTDDHLKGLMSDV---FLAGVNAGSITMIWTMTELSRHPRVMRKLQE 327 Query: 1140 EVLREVG--KGDPSGDNLGKLKEMTMVLHETLRLYGPA-LFMQRKTTTDMVVGAITIPKE 1310 E+ +G K + ++L K++ + MV+ E RL+ PA L + R T +D+ + +IPK Sbjct: 328 EIRAALGPNKEKITEEDLEKVEYLKMVIEEAFRLHPPAPLLLPRLTMSDINIQGYSIPKN 387 Query: 1311 HAIVIGAPFMHRDKKVWGEDADQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAM 1490 I I + RD K W + D+F P RF + LL F G R C G + Sbjct: 388 TMIQINTYTIGRDPKNWTK-PDEFIPERFVDNPIEYKGQHFELLPFGAGRRVCPGMATGI 446 Query: 1491 LEAKSVMATVLQKFSFAL 1544 + + ++L F ++L Sbjct: 447 TIVELGLLSLLYFFDWSL 464
>Q16850:CP51A_HUMAN Cytochrome P450 51A1 - Homo sapiens (Human)| Length = 503 Score = 82.8 bits (203), Expect = 5e-15 Identities = 80/301 (26%), Positives = 128/301 (42%), Gaps = 6/301 (1%) Frame = +3 Query: 672 DKSVQELTADII----SHTAFGSSYKLGMEAFYAQKELQAIAISSLLNVQIPGFSYLPTK 839 +K+V E +++I SH G + + AQ S +PG+ LP+ Sbjct: 191 EKNVFEALSELIILTASHCLHGKEIRSQLNEKVAQLYADLDGGFSHAAWLLPGWLPLPSF 250 Query: 840 RNRRKWMLEKKLRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGGKQEQLSLSME 1019 R R + ++++ + I R SQ +D+L +L+ T + G+ L+ + Sbjct: 251 RRRDR--AHREIKDIFYKAIQKRRQSQEKI--DDILQTLLDA---TYKDGRP----LTDD 299 Query: 1020 EILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGKGDP--SGDNLGK 1193 E+ AG T+S W F L+ Q++ E G+ P + D L Sbjct: 300 EVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKTVCGENLPPLTYDQLKD 359 Query: 1194 LKEMTMVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDA 1373 L + + ETLRL P + M R T V TIP H + + R K W E Sbjct: 360 LNLLDRCIKETLRLRPPIMIMMRMARTPQTVAGYTIPPGHQVCVSPTVNQRLKDSWVERL 419 Query: 1374 DQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSPS 1553 D FNP R+ A+ A + F G CIG+NFA ++ K++ +T+L+ + F L Sbjct: 420 D-FNPDRYLQD-NPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEFDLIDG 477 Query: 1554 Y 1556 Y Sbjct: 478 Y 478
>Q4PJW3:CP51A_BOVIN Cytochrome P450 51A1 - Bos taurus (Bovine)| Length = 502 Score = 82.8 bits (203), Expect = 5e-15 Identities = 71/251 (28%), Positives = 113/251 (45%), Gaps = 2/251 (0%) Frame = +3 Query: 810 IPGFSYLPTKRNRRKWMLEKKLRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGG 989 +PG+ LP+ R R + +++++ + I R S +D+L +LE T + G Sbjct: 240 LPGWLPLPSFRRRDR--AHREIKNIFYKAIQKRRESGEKI--DDILQTLLES---TYKDG 292 Query: 990 KQEQLSLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGKGD 1169 + L+ +E+ AG T+S W F L+ QE+ E G+ Sbjct: 293 RP----LTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQEKCFLEQKTVCGENL 348 Query: 1170 P--SGDNLGKLKEMTMVLHETLRLYGPALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMH 1343 P + D L L + + ETLRL P + M R T + V TIP H + + Sbjct: 349 PPLTYDQLKDLNLLDRCIKETLRLRPPIMTMMRLAKTPLTVAGYTIPPGHQVCVSPTVNQ 408 Query: 1344 RDKKVWGEDADQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVL 1523 R K W E D FNP R+ + A+ A + F G CIG+NFA ++ K++ +T+L Sbjct: 409 RLKDSWVERLD-FNPDRYLED-SPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTML 466 Query: 1524 QKFSFALSPSY 1556 + + F L Y Sbjct: 467 RLYEFDLIDGY 477
>Q92090:CP2K1_ONCMY Cytochrome P450 2K1 - Oncorhynchus mykiss (Rainbow trout) (Salmo| gairdneri) Length = 504 Score = 82.8 bits (203), Expect = 5e-15 Identities = 106/436 (24%), Positives = 175/436 (40%), Gaps = 16/436 (3%) Frame = +3 Query: 342 QYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHFPKNDAHPNXXXXXXXXXXXXXXXD- 518 +YG F FG K + + Y+ V+Q L +++ F D P D Sbjct: 72 KYGSIFTVHFGPKKVVVLAGYKTVKQALVNQAEDFGDRDITPVFYDFNQGHGILFANGDS 131 Query: 519 WVRHRRVIDPA---FAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQVEFDKSVQE 689 W RR F M K K + ++ VFE+ K + +SV Sbjct: 132 WKEMRRFALTNLRDFGMGK-KGSEEKILEEIPYLIEVFEKHEGK------AFDTTQSVLY 184 Query: 690 LTADIISHTAFGSSYKLGMEAF--YAQKELQAIAISSLLNVQIPG-FSYL-PTKRNRRKW 857 ++IIS +GS ++ F A + ++I ++ ++Q+ F +L P N + Sbjct: 185 AVSNIISAIVYGSRFEYTDPLFTGMADRAKESIHLTGSASIQMYNMFPWLGPWINNLTR- 243 Query: 858 MLEKKLRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGGKQE-QLSLSMEEILHE 1034 L+K + M +I G L M G ++ KQ + S M+ H+ Sbjct: 244 -LKKNIADMKMEVIELV-----RGLKETLNPHMCRGFVDSFLVRKQTLEESGHMDSFYHD 297 Query: 1035 CK------TFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGKGDPSGDNLGKL 1196 F AG +TT L W + L++ YP Q++++ E+ R +G ++ L Sbjct: 298 DNLVFSVGNLFSAGTDTTGTTLRWGLLLMTKYPHIQDQVQEEISRVIGSRQTLVEDRKNL 357 Query: 1197 KEMTMVLHETLRLYG-PALFMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDA 1373 V+HET RL + + T+ D+ I K +++ + +D W E Sbjct: 358 PYTDAVIHETQRLANIVPMSVPHTTSRDVTFQGYFIKKGTSVIPLLTSVLQDDSEW-ESP 416 Query: 1374 DQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSPS 1553 + FNP F + K A +AFS G R C+G+ A +E ++LQ+F F+ P Sbjct: 417 NTFNPSHFLDEQGGFVK-RDAFMAFSAGRRVCLGEGLARMELFLFFTSLLQRFRFSPPPG 475 Query: 1554 YVHAPADFLTLRPKFG 1601 D L L P G Sbjct: 476 VTE---DDLDLTPLLG 488
>P52786:CP2J1_RABIT Cytochrome P450 2J1 - Oryctolagus cuniculus (Rabbit)| Length = 501 Score = 82.8 bits (203), Expect = 5e-15 Identities = 100/436 (22%), Positives = 165/436 (37%), Gaps = 16/436 (3%) Frame = +3 Query: 279 LHVRDHDYLHRVAPHFLKWRAQYGEPFLFWFGAKPRICVFDYELVRQILSSKSGHFPKND 458 L D + H F+K +YG F K + V L++++L +F Sbjct: 56 LFTLDMEKSHLQLQQFVK---KYGNLFCLDLAGKSIVIVTGLPLIKEVLVHMDQNFINRP 112 Query: 459 AHPNXXXXXXXXXXXXXXXD-WVRHRRVIDPAFAMDKIKAM---TKTMVSCAQSTFGVFE 626 P W RR FA+ ++ K++ Q Sbjct: 113 VPPIRERSFKKNGLIMSSGQLWKEQRR-----FALMTLRNFGLGKKSLEERIQEEARHLT 167 Query: 627 EQASKNTNKEIQVEFDKSVQELTADIISHTAFGSSYKLG-------MEAFYAQKELQAIA 785 E K + F + ++II FG ++ ++ F L+A Sbjct: 168 EAMEKEGGQPFDAHF--KINNAVSNIICSITFGERFEYHDGQFQELLKLFDEVMYLEASM 225 Query: 786 ISSLLNVQIPGFSYLPTKRNR--RKWMLEKKLRSTLMRIINSRLASQGSGYGNDLLGLML 959 + L N+ +LP W KKL + R++ + D + L Sbjct: 226 LCQLYNIFPWIMKFLPGAHQTLFSNW---KKLELFVSRMLENHKKDWNPAETRDFIDAYL 282 Query: 960 EGCTETEQGGKQEQLSLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRA 1139 + E + S + E ++ F AG ETTS + W + +++YPE QE++ A Sbjct: 283 K---EMSKYPGSATSSFNEENLICSTLDLFLAGTETTSDM-RWGLLFMALYPEIQEKVHA 338 Query: 1140 EVLREVGKGD-PSGDNLGKLKEMTMVLHETLRLYGPA-LFMQRKTTTDMVVGAITIPKEH 1313 E+ +G+ PS + L V+HE R+ L + R+ T D + +PK Sbjct: 339 EIDSVIGQWQQPSMASRESLPYTNAVIHEVQRMGNILPLNVPREVTVDTTLAGYHLPKGT 398 Query: 1314 AIVIGAPFMHRDKKVWGEDADQFNPMRFA-NGVARAAKVPHALLAFSIGPRACIGQNFAM 1490 ++ +H+D + W D FNP F NG K A + FSIG RAC+G+ A Sbjct: 399 VVLTNLTALHKDPEEWATP-DTFNPEHFLENG---QFKKKEAFIPFSIGKRACLGEQLAK 454 Query: 1491 LEAKSVMATVLQKFSF 1538 E +++QKF+F Sbjct: 455 SELFIFFTSLMQKFTF 470
>Q9LTM4:C71BJ_ARATH Cytochrome P450 71B19 - Arabidopsis thaliana (Mouse-ear cress)| Length = 502 Score = 82.8 bits (203), Expect = 5e-15 Identities = 76/331 (22%), Positives = 143/331 (43%), Gaps = 15/331 (4%) Frame = +3 Query: 627 EQASKNTNKEIQVEFDKSVQELTADIISHTAFGSSY---------KLGMEAFYAQKELQA 779 +Q S++ V+ KS+ LTA I+ A G ++ K+ F A+ L + Sbjct: 155 KQLSESAVDRSPVDLSKSLFWLTASILFRVALGQNFHESDFIDKEKIEELVFEAETALAS 214 Query: 780 IAISSLLNVQIPGFSYLP---TKRNRRKWMLEKKLRSTLMRIINSRLASQGSGYGNDLLG 950 S V G +L + +++R + KL + +I+ L S D++ Sbjct: 215 FTCSDFFPVA--GLGWLVDWFSGQHKRLNDVFYKLDALFQHVIDDHLNPGRSKEHEDIID 272 Query: 951 LMLEGCTETEQGGKQEQLSLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQER 1130 ML+ + G+ L L+++ I F AG +T ++ + W V L P+ ++ Sbjct: 273 SMLD---VIHKQGEDSSLELTIDHIKGFLANIFLAGIDTGAITMIWAVTELVKNPKLIKK 329 Query: 1131 LRAEVLREVGKGDP--SGDNLGKLKEMTMVLHETLRLYGPA-LFMQRKTTTDMVVGAITI 1301 ++ ++ ++G + +++ K+ + MV+ ET RL+ A L + R+T + V I Sbjct: 330 VQGDIREQLGSNKERITEEDIEKVPYLKMVIKETFRLHPAAPLILPRETMAHIKVQGYDI 389 Query: 1302 PKEHAIVIGAPFMHRDKKVWGEDADQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQN 1481 P + I++ + RD K+W + +F+P RF + + LL F G R C G Sbjct: 390 PPKRRILVNVSAIGRDPKLW-TNPKEFDPERFMDSFVDYRGQHYELLPFGSGRRICPGMP 448 Query: 1482 FAMLEAKSVMATVLQKFSFALSPSYVHAPAD 1574 + + + +L F + L H D Sbjct: 449 MGIAAVELGLLNLLYFFDWKLPDGMTHKDID 479
>P37118:C71A2_SOLME Cytochrome P450 71A2 - Solanum melongena (Eggplant) (Aubergine)| Length = 505 Score = 82.8 bits (203), Expect = 5e-15 Identities = 112/459 (24%), Positives = 185/459 (40%), Gaps = 31/459 (6%) Frame = +3 Query: 330 KWRAQYGEPFLFWFGAKPRICVFDYELVRQILSSKS---GHFPKNDAHPNXXXXXXXXXX 500 K +YG L FG+KP I + R I+ + PK+ Sbjct: 63 KLSQKYGPVMLLHFGSKPVIVASSVDAARDIMKTHDVVWASRPKSSIVDRLSYGSKDVGF 122 Query: 501 XXXXXDWVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTNKEIQ------ 662 W R A ++ + ++ T V QS V E+ + K Q Sbjct: 123 SPFGEYWRR-------AKSITVLHLLSNTRV---QSYRNVRAEETANMIGKIRQGCDSSV 172 Query: 663 VEFDKSVQELTADIISHTAFGSSY---KLGMEAFYAQKELQAIAISSLLNV--QIPGFSY 827 + + + LT +IIS A G +Y + G+E Q + + + NV IP + Sbjct: 173 INLGEHLCSLTNNIISRVALGRTYDEKESGIEHIIEQ----FVELLGIFNVGDYIPRLEW 228 Query: 828 LP--TKRNRRKWMLEKKLRSTLMRIINSRLASQ------GSGYGNDLLGLMLEGCTETEQ 983 + T + + + K+L L +I + + +G D + ++LE Q Sbjct: 229 VNKFTGLDAKVKKVAKELDMFLEIVIEEHIIRKKKEEYTSTGEAKDFVDVLLE-----IQ 283 Query: 984 GGKQEQLSLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREV-G 1160 G + L + + F AG +TT L WT+ L P + L+ EV G Sbjct: 284 NGNETDFPLQRDSLKAILLDSFAAGTDTTFATLDWTMAELLRQPRALKTLQDEVRGLAQG 343 Query: 1161 KGDPSGDNLGKLKEMTMVLHETLRLYGP--ALFMQRKTTTDM-VVGAITIPKEHAIVIGA 1331 K + + D+L ++ + V+ E+LRL+ +L + R++ D+ ++G IP +I A Sbjct: 344 KSEITEDDLKNMQYLRAVIKESLRLHPTQESLLVPRESMEDVNLLGYYHIPARTQAIINA 403 Query: 1332 PFMHRDKKVWGEDADQFNPMRFANGVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVM 1511 + RD W E+ +++ P RF N A + LL F G R C G +FA+ + + Sbjct: 404 WAIGRDPLSW-ENPEEYQPERFLNSDADVKGLNFKLLPFGAGRRGCPGSSFAIAVIELAL 462 Query: 1512 ATVLQKFSFALSPSYVHAPADF-----LTLRPKFGLPVV 1613 A ++ KF FAL D +T R K L VV Sbjct: 463 ARLVHKFDFALPEGIKPEDLDMTETIGITTRRKLPLLVV 501
>Q9VMS8:C4AC2_DROME Probable cytochrome P450 4ac2 - Drosophila melanogaster (Fruit fly)| Length = 497 Score = 82.8 bits (203), Expect = 5e-15 Identities = 66/216 (30%), Positives = 102/216 (47%), Gaps = 3/216 (1%) Frame = +3 Query: 894 IINSRLASQGSGYGNDLLGLMLEGCTETEQGGKQEQLSLSMEEILHECKTFFFAGYETTS 1073 + S Q +G ML+ E G+ + + I E TF F GY+TTS Sbjct: 256 LFKSNQLGQEDEFGKKQRYAMLDTLLAAEADGQ-----IDHQGICDEVNTFMFEGYDTTS 310 Query: 1074 LLLTWTVFLLSVYPEWQERLRAEVLREVGKGDP-SGDNLGKLKEMTMVLHETLRLYGPAL 1250 L +T+ +L+++ + Q++ E+ D S +L M V+ E+LRL+ Sbjct: 311 TCLIFTLLMLALHEDVQKKCYEEIKYLPDDSDDISVFQFNELVYMECVIKESLRLFPSVP 370 Query: 1251 FMQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDADQFNPMRF--ANGVARAAK 1424 F+ R+ + VV + +PK I I + RD + + + F P RF N V R Sbjct: 371 FIGRRCVEEGVVNGLIMPKNTQINIHLYEIMRDARHFS-NPKMFQPDRFFPENTVNRH-- 427 Query: 1425 VPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKF 1532 P A + FS G R CIGQ FA+LE K ++A V++ F Sbjct: 428 -PFAFVPFSAGQRNCIGQKFAILEIKVLLAAVIRNF 462
>Q9VMT5:C28D1_DROME Probable cytochrome P450 28d1 - Drosophila melanogaster (Fruit fly)| Length = 502 Score = 82.8 bits (203), Expect = 5e-15 Identities = 58/229 (25%), Positives = 106/229 (46%), Gaps = 7/229 (3%) Frame = +3 Query: 885 LMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGGKQEQLSLSMEEILHECKTFFFAGYE 1064 + + I R S + +D L ML+ QE+ L+ E+ TF G+E Sbjct: 259 MQKCIQVRRESPAAQQRDDFLNYMLQ---------LQEKKGLNAAELTSHTMTFLTDGFE 309 Query: 1065 TTSLLLTWTVFLLSVYPEWQERLRAEVLREVGKGDPSGDNLGKLKEMTMVLHETLRLYGP 1244 TT+ +LT T+ L+ P+ Q +LR E+G + + + + +L +HETLR++ P Sbjct: 310 TTAQVLTHTLLFLARNPKEQMKLR----EEIGTAELTFEQISELPFTEACIHETLRIFSP 365 Query: 1245 ALFMQRKTT-----TDMVVGAITIPKEHAIVIGAPFMHRDKKVWGEDADQFNPMRFAN-- 1403 L ++ T T+ ++ + ++I +H D + + E+ F P RF N Sbjct: 366 VLAARKVVTEPCELTNKNGVSVKLRPGDVVIIPVNALHHDPQYY-EEPQSFKPERFLNIN 424 Query: 1404 GVARAAKVPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFALSP 1550 G A+ + F GPR C G F++ + K+ + +++ F ++P Sbjct: 425 GGAKKYRDQGLFFGFGDGPRICPGMRFSLTQIKAALVEIVRNFDIKVNP 473
>P00184:CP1A1_MOUSE Cytochrome P450 1A1 - Mus musculus (Mouse)| Length = 524 Score = 82.4 bits (202), Expect = 6e-15 Identities = 85/380 (22%), Positives = 153/380 (40%), Gaps = 18/380 (4%) Frame = +3 Query: 519 WVRHRRVIDPAFAMDKIKAMTKTMVSCAQSTFGVFEEQASKNTN------KEIQVE---F 671 W RR+ A I + + SC EE SK N +++ E F Sbjct: 135 WAARRRLAQNALKSFSIASDPTSASSC------YLEEHVSKEANYLVSKLQKVMAEVGHF 188 Query: 672 D--KSVQELTADIISHTAFGSSYKLGMEAFYA----QKELQAIAISSLLNVQIPGFSYLP 833 D K + A++I FG Y + + E + S IP YLP Sbjct: 189 DPYKYLVVSVANVICAICFGQRYDHDDQELLSIVNLSNEFGEVTGSGYPADFIPVLRYLP 248 Query: 834 TKRNRRKWMLEKKLRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGGKQEQLSLS 1013 L K S + ++I + G+ D+ ++E C + + + + LS Sbjct: 249 NSSLDAFKDLNDKFYSFMKKLIKEHYRTFEKGHIRDITDSLIEHCQDRKLD-ENANVQLS 307 Query: 1014 MEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVGKG-DPSGDNLG 1190 ++++ F AG++T + ++W++ L P Q +++ E+ +G+ P + Sbjct: 308 DDKVITIVLDLFGAGFDTVTTAISWSLMYLVTNPRVQRKIQEELDTVIGRDRQPRLSDRP 367 Query: 1191 KLKEMTMVLHETLRLYGPALF-MQRKTTTDMVVGAITIPKEHAIVIGAPFMHRDKKVWGE 1367 +L + + ET R F + TT D + IPK + + ++ D+++WG Sbjct: 368 QLPYLEAFILETFRHSSFVPFTIPHSTTRDTSLNGFYIPKGCCVFVNQWQVNHDRELWG- 426 Query: 1368 DADQFNPMRFANGVARAAK-VPHALLAFSIGPRACIGQNFAMLEAKSVMATVLQKFSFAL 1544 D ++F P RF K + + F +G R CIG+ E +A +LQ+ F + Sbjct: 427 DPNEFRPERFLTPSGTLDKRLSEKVTLFGLGKRKCIGETIGRSEVFLFLAILLQQIEFKV 486 Query: 1545 SPSYVHAPADFLTLRPKFGL 1604 S P + + + P +GL Sbjct: 487 S------PGEKVDMTPTYGL 500
>Q92148:CP1A1_MICTO Cytochrome P450 1A1 - Microgadus tomcod (Atlantic tomcod)| Length = 515 Score = 82.4 bits (202), Expect = 6e-15 Identities = 69/275 (25%), Positives = 123/275 (44%), Gaps = 5/275 (1%) Frame = +3 Query: 810 IPGFSYLPTKRNRRKWMLEKKLRSTLMRIINSRLASQGSGYGNDLLGLMLEGCTETEQGG 989 IP +LP +R + ++ + + +I+ + D+ +++ C E + Sbjct: 238 IPLLRFLPNATMKRFMAINERFMTFVQKIVTEHYNTYDKDNIRDITDSLIDHC-EDRKLD 296 Query: 990 KQEQLSLSMEEILHECKTFFFAGYETTSLLLTWTVFLLSVYPEWQERLRAEVLREVG-KG 1166 + + +S E+I+ F AG++T S L+W+V L +PE QERL E+ +VG Sbjct: 297 ENSNIQMSDEKIVGIVNDLFGAGFDTVSTALSWSVMYLVAHPEIQERLHQEIKDKVGLSR 356 Query: 1167 DPSGDNLGKLKEMTMVLHETLRLYGPALF-MQRKTTTDMVVGAITIPKEHAIVIGAPFMH 1343 P + L + + E R F + T D + IPK+ + I ++ Sbjct: 357 SPVLTDRHNLPILEAFIFEIFRHSSFLPFTIPHCATKDTSLDGYFIPKDTCVFINQWQIN 416 Query: 1344 RDKKVWGEDADQFNPMRFANGVARAAK--VPHALLAFSIGPRACIGQNFAMLEAKSVMAT 1517 D ++W E + FNP RF + A ++ F +G R CIG+ A E +A Sbjct: 417 HDPELWKEPS-TFNPDRFLSADASELNKLAGEKVMLFGMGKRRCIGEMVARNEVFLFLAI 475 Query: 1518 VLQKFSFALSPSYVHA-PADFLTLRPKFGLPVVMK 1619 ++Q+ +F HA P + L + P++GL + K Sbjct: 476 LVQRLTF-------HAVPGEPLDMTPEYGLTMKHK 503 Database: uniprot_sprot.fasta.out Posted date: Jul 19, 2007 5:58 PM Number of letters in database: 100,686,439 Number of sequences in database: 274,295 Lambda K H 0.318 0.134 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 274295 Number of Hits to DB: 323,502,269 Number of extensions: 7401170 Number of successful extensions: 24845 Number of sequences better than 10.0: 754 Number of HSP's gapped: 23884 Number of HSP's successfully gapped: 790 Length of query: 629 Length of database: 100,686,439 Length adjustment: 119 Effective length of query: 510 Effective length of database: 68,045,334 Effective search space: 34703120340 Effective search space used: 34703120340 Neighboring words threshold: 12 Window for multiple hits: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)
