>O12947:ICMT_XENLA Protein-S-isoprenylcysteine O-methyltransferase - Xenopus laevis|
           (African clawed frog)
          Length = 288
 Score =  167 bits (424), Expect = 5e-41
 Identities = 83/179 (46%), Positives = 118/179 (65%), Gaps = 2/179 (1%)
 Frame = +2

Query: 128 LVLFHGSEYILAAFFHGHRNVTATSLLI--SKQYVLAMSFAMAEHLTESLFFPEIKGYLF 301
           L  FH SEY++ A  +  R+++  S L+  S +Y LA   +  E   E+  +P++K   +
Sbjct: 104 LSFFHYSEYLVTAM-NNPRSLSIDSFLLNHSLEYTLAALSSWVEFTIETTIYPDLKQITW 162

Query: 302 VSNIGLLMVLFGEIIRKIAVVTAGRAFTHVIRIQYEDQHQLVTHGIYRFMRHPGYSGFLL 481
           +S IGL+MVLFGE++RK A++TAG  F H+++ +  D H LVT G+Y + RHP Y G+  
Sbjct: 163 LSVIGLIMVLFGEVLRKCAMLTAGSNFNHIVQNEKSDSHTLVTSGVYSWFRHPSYVGWFY 222

Query: 482 WAVGTQVMLCNPVSTVLFALVLWRFFSKRIPYEEFFLRQFFGSQYEEYARKVHSGLPFI 658
           W++GTQV+LCNP+  V + L  WRFFS+RI  EEF L  FFG  Y EY +KV +GLPFI
Sbjct: 223 WSIGTQVLLCNPLCLVGYTLASWRFFSERIEEEEFSLIHFFGENYLEYKKKVPTGLPFI 281

>Q9WVM4:ICMT_RAT Protein-S-isoprenylcysteine O-methyltransferase - Rattus norvegicus|
           (Rat)
          Length = 232

 Score =  164 bits (414), Expect = 7e-40
 Identities = 80/179 (44%), Positives = 118/179 (65%), Gaps = 2/179 (1%)
 Frame = +2

Query: 128 LVLFHGSEYILAAFFHGHRNVTATSLLI--SKQYVLAMSFAMAEHLTESLFFPEIKGYLF 301
           L LFH SEY++    +  ++++  S L+  S +Y +A   +  E   E++F+PE+K   +
Sbjct: 48  LSLFHYSEYLVTTV-NNPKSLSLDSFLLNHSLEYTVAALSSWIEFTLENIFWPELKQITW 106

Query: 302 VSNIGLLMVLFGEIIRKIAVVTAGRAFTHVIRIQYEDQHQLVTHGIYRFMRHPGYSGFLL 481
           +S  GLLMV+FGE +RK+A+ TAG  F HV++ +  D H LVT G+Y + RHP Y G+  
Sbjct: 107 LSAAGLLMVIFGECLRKVAMFTAGSNFNHVVQSEKSDTHTLVTSGVYAWCRHPSYVGWFY 166

Query: 482 WAVGTQVMLCNPVSTVLFALVLWRFFSKRIPYEEFFLRQFFGSQYEEYARKVHSGLPFI 658
           W++GTQVMLCNP+  V++AL +WRFF  R   EE  L  FFG +Y +Y ++V +GLPFI
Sbjct: 167 WSIGTQVMLCNPICGVVYALTVWRFFRDRTEEEEISLIHFFGEEYLDYKKRVPTGLPFI 225

>Q9EQK7:ICMT_MOUSE Protein-S-isoprenylcysteine O-methyltransferase - Mus musculus|
           (Mouse)
          Length = 283

 Score =  163 bits (413), Expect = 1e-39
 Identities = 81/179 (45%), Positives = 118/179 (65%), Gaps = 2/179 (1%)
 Frame = +2

Query: 128 LVLFHGSEYILAAFFHGHRNVTATSLLI--SKQYVLAMSFAMAEHLTESLFFPEIKGYLF 301
           L LFH SEY++ A  +  ++++  S L+  S +Y +A   +  E   E++F+PE+K   +
Sbjct: 99  LSLFHYSEYLVTAV-NNPKSLSLDSFLLNHSLEYTVAALSSWIEFTLENIFWPELKQITW 157

Query: 302 VSNIGLLMVLFGEIIRKIAVVTAGRAFTHVIRIQYEDQHQLVTHGIYRFMRHPGYSGFLL 481
           +S  GLLMV+FGE +RK A+ TAG  F HV++ +  D H LVT G+Y + RHP Y G+  
Sbjct: 158 LSATGLLMVVFGECLRKAAMFTAGSNFNHVVQSEKSDTHTLVTSGVYAWCRHPSYVGWFY 217

Query: 482 WAVGTQVMLCNPVSTVLFALVLWRFFSKRIPYEEFFLRQFFGSQYEEYARKVHSGLPFI 658
           W++GTQVMLCNP+  V++AL +WRFF  R   EE  L  FFG +Y +Y ++V +GLPFI
Sbjct: 218 WSIGTQVMLCNPICGVVYALTVWRFFRDRTEEEEISLIHFFGEEYLDYKKRVPTGLPFI 276

>O60725:ICMT_HUMAN Protein-S-isoprenylcysteine O-methyltransferase - Homo sapiens|
           (Human)
          Length = 284

 Score =  163 bits (412), Expect = 1e-39
 Identities = 82/179 (45%), Positives = 117/179 (65%), Gaps = 2/179 (1%)
 Frame = +2

Query: 128 LVLFHGSEYILAAFFHGHRNVTATSLLI--SKQYVLAMSFAMAEHLTESLFFPEIKGYLF 301
           L LFH SEY++ A  +  ++++  S L+  S +Y +A   +  E   E++F+PE+K   +
Sbjct: 100 LSLFHYSEYLVTAV-NNPKSLSLDSFLLNHSLEYTVAALSSWLEFTLENIFWPELKQITW 158

Query: 302 VSNIGLLMVLFGEIIRKIAVVTAGRAFTHVIRIQYEDQHQLVTHGIYRFMRHPGYSGFLL 481
           +S  GLLMV+FGE +RK A+ TAG  F HV++ +  D H LVT G+Y + RHP Y G+  
Sbjct: 159 LSVTGLLMVVFGECLRKAAMFTAGSNFNHVVQNEKSDTHTLVTSGVYAWFRHPSYVGWFY 218

Query: 482 WAVGTQVMLCNPVSTVLFALVLWRFFSKRIPYEEFFLRQFFGSQYEEYARKVHSGLPFI 658
           W++GTQVMLCNP+  V +AL +WRFF  R   EE  L  FFG +Y EY ++V +GLPFI
Sbjct: 219 WSIGTQVMLCNPICGVSYALTVWRFFRDRTEEEEISLIHFFGEEYLEYKKRVPTGLPFI 277

>P32584:STE14_YEAST Protein-S-isoprenylcysteine O-methyltransferase - Saccharomyces|
           cerevisiae (Baker's yeast)
          Length = 239

 Score =  152 bits (384), Expect = 2e-36
 Identities = 80/185 (43%), Positives = 118/185 (63%), Gaps = 8/185 (4%)
 Frame = +2

Query: 128 LVLFHGSEYILAAFFHGHRNVTATSLLIS--KQYVLAMSFAMAEHLTESLFFPEIKGYLF 301
           L LFH  EY + A ++  + V + S L++  K Y+ A SFA+ E L ES  FP++K + +
Sbjct: 56  LSLFHFLEYYITAKYNPLK-VHSESFLLNNGKSYMAAHSFAILECLVESFLFPDLKIFSY 114

Query: 302 ------VSNIGLLMVLFGEIIRKIAVVTAGRAFTHVIRIQYEDQHQLVTHGIYRFMRHPG 463
                  + +G L+V+ G+  R IA+ TAG +F+H+++ + E  H LV  G+Y + RHP 
Sbjct: 115 SLATKLCTVLGCLLVILGQYTRTIAMHTAGHSFSHIVKTKKESDHVLVKTGVYSWSRHPS 174

Query: 464 YSGFLLWAVGTQVMLCNPVSTVLFALVLWRFFSKRIPYEEFFLRQFFGSQYEEYARKVHS 643
           Y GF  WA+GTQ++L NP+S V+F  VLW+FFS RI  EE +L +FF ++Y EY  KV  
Sbjct: 175 YLGFFWWAIGTQLLLLNPLSLVIFIFVLWKFFSDRIRVEEKYLIEFFSAEYIEYKNKVGV 234

Query: 644 GLPFI 658
           G+PFI
Sbjct: 235 GIPFI 239

>P87014:MAM4_SCHPO Protein-S-isoprenylcysteine O-methyltransferase -|
           Schizosaccharomyces pombe (Fission yeast)
          Length = 236

 Score =  134 bits (337), Expect = 6e-31
 Identities = 80/193 (41%), Positives = 115/193 (59%), Gaps = 16/193 (8%)
 Frame = +2

Query: 128 LVLFHGSEYILAAFFHGHRNVTATSLLIS-KQYVLAMSFAMAEHLTES----------LF 274
           L LFH  E+ + A F G +    + +L + K Y LAM   + E L             L 
Sbjct: 45  LSLFHLLEFYITARFQGSQLSWDSFILNNGKAYWLAMLVGLLECLLSGGKSFAKVINCLR 104

Query: 275 FPE-IKGYLF----VSNIGLLMVLFGEIIRKIAVVTAGRAFTHVIRIQYEDQHQLVTHGI 439
           FP  +  ++F     S +G L +  G+ +R  A+V AG++F+H++  +    H LVT GI
Sbjct: 105 FPSFLINFIFSVYQTSALGFLCL--GQYLRSSAMVQAGQSFSHIVASKRNKDHLLVTDGI 162

Query: 440 YRFMRHPGYSGFLLWAVGTQVMLCNPVSTVLFALVLWRFFSKRIPYEEFFLRQFFGSQYE 619
           Y ++RHP Y GF +WA+GTQ++L N VST+LF+LVLW+FFS+RI  EE +L  FFG  YE
Sbjct: 163 YAYVRHPSYVGFFIWALGTQMLLGNFVSTLLFSLVLWKFFSQRITTEEAYLVSFFGDSYE 222

Query: 620 EYARKVHSGLPFI 658
           +Y +KV SG+P I
Sbjct: 223 QYRKKVPSGIPLI 235

>P29940:YCB7_PSEDE Uncharacterized protein in cobO 3'region - Pseudomonas|
           denitrificans
          Length = 197

 Score = 50.4 bits (119), Expect = 1e-05
 Identities = 31/82 (37%), Positives = 42/82 (51%)
 Frame = +2

Query: 392 IRIQYEDQHQLVTHGIYRFMRHPGYSGFLLWAVGTQVMLCNPVSTVLFALVLWRFFSKRI 571
           I I  +    LVT G+Y F R+P Y G +   +GT + + N +S  L AL  W   S +I
Sbjct: 113 IGIPEKQDAPLVTSGLYAFSRNPIYVGMVTALIGTVMAVPNVISVAL-ALSAWISISYQI 171

Query: 572 PYEEFFLRQFFGSQYEEYARKV 637
             EE  L + FG  Y  Y R+V
Sbjct: 172 RMEETHLAKVFGDAYGAYCRRV 193

>P94139:CZCN_RALME Cobalt-zinc-cadmium resistance protein czcN - Ralstonia|
           metallidurans (strain CH34 / ATCC 43123 / DSM 2839)
          Length = 216

 Score = 38.9 bits (89), Expect = 0.036
 Identities = 30/100 (30%), Positives = 45/100 (45%)
 Frame = +2

Query: 353 IAVVTAGRAFTHVIRIQYEDQHQLVTHGIYRFMRHPGYSGFLLWAVGTQVMLCNPVSTVL 532
           +++ T GR +   + I     + LVT G Y   RHP Y   LL  +G   M  +   T +
Sbjct: 65  VSLATVGRLWC-ALYISGRKNNTLVTSGPYSLCRHPLYVCNLLGILGLGAMTESLAVTAV 123

Query: 533 FALVLWRFFSKRIPYEEFFLRQFFGSQYEEYARKVHSGLP 652
            AL     +   I  E+ FL   F  ++ EYAR+  +  P
Sbjct: 124 LALAFALMYPAVIRTEDRFLASAF-PEFAEYARRTPAFFP 162

>Q44587:NCCN_ALCXX Nickel-cobalt-cadmium resistance protein nccN - Alcaligenes|
           xylosoxydans xylosoxydans (Achromobacter xylosoxidans)
          Length = 213

 Score = 33.5 bits (75), Expect = 1.5
 Identities = 26/100 (26%), Positives = 43/100 (43%)
 Frame = +2

Query: 353 IAVVTAGRAFTHVIRIQYEDQHQLVTHGIYRFMRHPGYSGFLLWAVGTQVMLCNPVSTVL 532
           + + T GR +   + I      +LVT G Y   RHP Y    +  VG   M  +     +
Sbjct: 62  VTMATVGRLWC-ALYISGRKSTELVTTGPYSMCRHPLYVCNFVGIVGLGAMTESITLAAI 120

Query: 533 FALVLWRFFSKRIPYEEFFLRQFFGSQYEEYARKVHSGLP 652
            AL     +   I  E+  L + F  ++++YAR+  +  P
Sbjct: 121 LALAFALMYPAVIRSEDHLLSRNF-PEFDDYARRTPAFFP 159

>P70398:USP9X_MOUSE Probable ubiquitin carboxyl-terminal hydrolase FAF-X - Mus musculus|
           (Mouse)
          Length = 2559

 Score = 33.1 bits (74), Expect = 2.0
 Identities = 16/31 (51%), Positives = 18/31 (58%)
 Frame = +1

Query: 1   GTSPTPSISSRCPSPEPQRKLRSPDPRSAHG 93
           GT P  S+SS    PE +   RSPDPRS  G
Sbjct: 189 GTRPCESVSSSVQLPEDELFARSPDPRSPKG 219

>Q93008:USP9X_HUMAN Probable ubiquitin carboxyl-terminal hydrolase FAF-X - Homo sapiens|
           (Human)
          Length = 2547

 Score = 33.1 bits (74), Expect = 2.0
 Identities = 16/31 (51%), Positives = 18/31 (58%)
 Frame = +1

Query: 1   GTSPTPSISSRCPSPEPQRKLRSPDPRSAHG 93
           GT P  S+SS    PE +   RSPDPRS  G
Sbjct: 182 GTRPCESVSSSVQLPEDELFARSPDPRSPKG 212

>Q14739:LBR_HUMAN Lamin-B receptor - Homo sapiens (Human)|
          Length = 615

 Score = 32.3 bits (72), Expect = 3.4
 Identities = 19/85 (22%), Positives = 38/85 (44%), Gaps = 1/85 (1%)
 Frame = +2

Query: 386 HVIRIQYEDQHQLVTHGIYRFMRHPGYSGFLLWAVGTQVML-CNPVSTVLFALVLWRFFS 562
           H+  I       L+  G + F+RHP Y G L+ A+   +    N +    + +       
Sbjct: 522 HLKTIHTSTGKNLLVSGWWGFVRHPNYLGDLIMALAWSLPCGFNHILPYFYIIYFTMLLV 581

Query: 563 KRIPYEEFFLRQFFGSQYEEYARKV 637
            R   +E+  ++ +G  +E+Y ++V
Sbjct: 582 HREARDEYHCKKKYGVAWEKYCQRV 606

>P43984:Y318_HAEIN Uncharacterized protein HI0318 - Haemophilus influenzae|
          Length = 172

 Score = 32.0 bits (71), Expect = 4.4
 Identities = 32/148 (21%), Positives = 62/148 (41%), Gaps = 1/148 (0%)
 Frame = +2

Query: 164 AFFHGHRNVTATSLLISKQYVLAMSFAMAEHLTESLFFPEIKGYLFVSNIGLLMVLFGEI 343
           A  +G RN T  S+     Y  A+  A  ++L+          +   S IGL +++F   
Sbjct: 34  AIQYGKRNSTLLSIAHVAFYFAAIIEANKQNLS----------FNSTSQIGLAILIFAIA 83

Query: 344 IRKIAVVTAGRAFTHVIRIQYEDQHQLVTHGIYRFMRHPGYSGFLLWAVGTQVMLCNPVS 523
           +    +      +T  ++I    +HQ+    +++++RHP Y   ++  +    + C    
Sbjct: 84  MLFYVIYELKEIWT--VKIYILPEHQINRSFLFKYVRHPNYFLNIIPELIGLSLFCQAKY 141

Query: 524 TVLFALVLW-RFFSKRIPYEEFFLRQFF 604
           T L  L ++    + RI  EE  +   F
Sbjct: 142 TALVGLPIYLLILAVRIKQEESAMSHLF 169

>Q5R7H4:LBR_PONPY Lamin-B receptor - Pongo pygmaeus (Orangutan)|
          Length = 615

 Score = 32.0 bits (71), Expect = 4.4
 Identities = 19/85 (22%), Positives = 37/85 (43%), Gaps = 1/85 (1%)
 Frame = +2

Query: 386 HVIRIQYEDQHQLVTHGIYRFMRHPGYSGFLLWAVGTQVML-CNPVSTVLFALVLWRFFS 562
           H+  I       L+  G + F RHP Y G L+ A+   +    N +    + +       
Sbjct: 522 HLKTIHTSTGKNLLVSGWWGFARHPNYLGDLIMALAWSLACGFNHILPYFYIIYFTMLLV 581

Query: 563 KRIPYEEFFLRQFFGSQYEEYARKV 637
            R   +E+  ++ +G  +E+Y ++V
Sbjct: 582 HREARDEYHCKKKYGVAWEKYCQRV 606

>Q3UHU5:K0802_MOUSE Uncharacterized protein KIAA0802 - Mus musculus (Mouse)|
          Length = 1945

 Score = 32.0 bits (71), Expect = 4.4
 Identities = 22/48 (45%), Positives = 25/48 (52%), Gaps = 5/48 (10%)
 Frame = +1

Query: 7   SPTPSISSRCP---SPEPQRKLRSPDPRSA--HGGAGTGVAVCGRPGP 135
           +PTPS  SR P   SPEP   L +P   SA   G +  G A  G PGP
Sbjct: 241 APTPSSGSRGPPPGSPEPPILLAAPPVASACLGGRSSPGGASTGSPGP 288

>P05374:PEM1_YEAST Phosphatidylethanolamine N-methyltransferase - Saccharomyces|
           cerevisiae (Baker's yeast)
          Length = 869

 Score = 31.6 bits (70), Expect = 5.7
 Identities = 24/92 (26%), Positives = 41/92 (44%), Gaps = 10/92 (10%)
 Frame = +2

Query: 305 SNIGLLMVLFGEII----------RKIAVVTAGRAFTHVIRIQYEDQHQLVTHGIYRFMR 454
           SNI    ++FG I+           ++A+   G  +       Y    +L + GIYR++ 
Sbjct: 465 SNINNSQLIFGLILVALQTWCDKETRLAISDFGWFYGDFFLSNYISTRKLTSQGIYRYLN 524

Query: 455 HPGYSGFLLWAVGTQVMLCNPVSTVLFALVLW 550
           HP     ++   GT +M    V+ ++ A VLW
Sbjct: 525 HPEAVLGVVGVWGTVLMTNFAVTNIILA-VLW 555

>Q80TC6:ZSWM5_MOUSE Zinc finger SWIM domain-containing protein 5 - Mus musculus (Mouse)|
          Length = 1188

 Score = 31.2 bits (69), Expect = 7.5
 Identities = 19/50 (38%), Positives = 23/50 (46%), Gaps = 2/50 (4%)
 Frame = +1

Query: 7   SPTPSISSR--CPSPEPQRKLRSPDPRSAHGGAGTGVAVCGRPGPLPRLR 150
           SP P   ++  C  P PQ       P +A GGAG G   C  PG  P L+
Sbjct: 12  SPPPISPAKRLCSWPSPQAHHPRGTPGAAGGGAGGGGGGCLAPGARPHLQ 61

>Q99PV3:MKLN1_RAT Muskelin - Rattus norvegicus (Rat)|
          Length = 735

 Score = 31.2 bits (69), Expect = 7.5
 Identities = 15/36 (41%), Positives = 19/36 (52%)
 Frame = -3

Query: 1041 WWSIYV*AHLIQLCYKGFHTANLLEMFDVLHKKRKL 934
            W+S Y     I+LC K F   N  E F+ L KK K+
Sbjct: 167  WYSKYREQEAIRLCLKHFRQHNYTEAFESLQKKTKI 202

>Q5RB35:MKLN1_PONPY Muskelin - Pongo pygmaeus (Orangutan)|
          Length = 735

 Score = 31.2 bits (69), Expect = 7.5
 Identities = 15/36 (41%), Positives = 19/36 (52%)
 Frame = -3

Query: 1041 WWSIYV*AHLIQLCYKGFHTANLLEMFDVLHKKRKL 934
            W+S Y     I+LC K F   N  E F+ L KK K+
Sbjct: 167  WYSKYREQEAIRLCLKHFRQHNYTEAFESLQKKTKI 202

>O89050:MKLN1_MOUSE Muskelin - Mus musculus (Mouse)|
          Length = 735

 Score = 31.2 bits (69), Expect = 7.5
 Identities = 15/36 (41%), Positives = 19/36 (52%)
 Frame = -3

Query: 1041 WWSIYV*AHLIQLCYKGFHTANLLEMFDVLHKKRKL 934
            W+S Y     I+LC K F   N  E F+ L KK K+
Sbjct: 167  WYSKYREQEAIRLCLKHFRQHNYTEAFESLQKKTKI 202

>Q9UL63:MKLN1_HUMAN Muskelin - Homo sapiens (Human)|
          Length = 735

 Score = 31.2 bits (69), Expect = 7.5
 Identities = 15/36 (41%), Positives = 19/36 (52%)
 Frame = -3

Query: 1041 WWSIYV*AHLIQLCYKGFHTANLLEMFDVLHKKRKL 934
            W+S Y     I+LC K F   N  E F+ L KK K+
Sbjct: 167  WYSKYREQEAIRLCLKHFRQHNYTEAFESLQKKTKI 202

>O08984:LBR_RAT Lamin-B receptor - Rattus norvegicus (Rat)|
          Length = 620

 Score = 31.2 bits (69), Expect = 7.5
 Identities = 20/85 (23%), Positives = 37/85 (43%), Gaps = 1/85 (1%)
 Frame = +2

Query: 386 HVIRIQYEDQHQLVTHGIYRFMRHPGYSGFLLWAVGTQVML-CNPVSTVLFALVLWRFFS 562
           H+  I       L+  G + F+RHP Y G L+ A+   +    N +    + +       
Sbjct: 527 HLKTIPTSTWKSLLVSGWWGFVRHPNYLGDLIMALAWSLPCGFNHILPYFYVIYFTALLI 586

Query: 563 KRIPYEEFFLRQFFGSQYEEYARKV 637
            R   +E   R+ +G  +E+Y ++V
Sbjct: 587 HREARDEHQCRRKYGLAWEKYCQRV 611


  Database: uniprot_sprot.fasta.out
    Posted date:  Jul 19, 2007  5:58 PM
  Number of letters in database: 100,686,439
  Number of sequences in database:  274,295
  
Lambda     K      H
   0.318    0.134    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 274295
Number of Hits to DB: 194,955,276
Number of extensions: 4482624
Number of successful extensions: 12690
Number of sequences better than 10.0: 22
Number of HSP's gapped: 12636
Number of HSP's successfully gapped: 22
Length of query: 351
Length of database: 100,686,439
Length adjustment: 114
Effective length of query: 237
Effective length of database: 69,416,809
Effective search space: 16451783733
Effective search space used: 16451783733
Neighboring words threshold: 12
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)