>Q304B9:NCASE_ARATH Neutral ceramidase precursor - Arabidopsis thaliana (Mouse-ear cress)|
          Length = 757
 Score = 1056 bits (2731), Expect = 0.0
 Identities = 522/746 (69%), Positives = 605/746 (81%), Gaps = 2/746 (0%)
 Frame = +1

Query: 697  YLVGMGSYDITGPAADVNMMGYANTEQIASGIHFRLKSRAFIVAEPNGERVVFVNLDACM 876
            YL+G+GSYDITGPAADVNMMGYAN++QIASGIHFRL++RAFIVAEP G RVVFVNLDACM
Sbjct: 26   YLIGVGSYDITGPAADVNMMGYANSDQIASGIHFRLRARAFIVAEPQGNRVVFVNLDACM 85

Query: 877  ASQLVNIKVLERLKARYGDLYNENNVAISGIHTHAGPGGYLQYVVYIVTSLGFVRQSFDV 1056
            ASQ+V IKVLERLKARYG+LY E NVAISGIHTHAGPGGYLQYV YIVTSLGFVRQSFDV
Sbjct: 86   ASQIVTIKVLERLKARYGELYTEKNVAISGIHTHAGPGGYLQYVTYIVTSLGFVRQSFDV 145

Query: 1057 IVDGIEQSIVEAHNNLHPGKIYVNKGDLIDAGVNRSPSAYLNNPAEERSKYKYNVDKEMT 1236
            +V+GIEQSIV+AH +L PG  +VNKGDL+DAGVNRSPS+YLNNPA ERSKYKY+VDKEMT
Sbjct: 146  VVNGIEQSIVQAHESLRPGSAFVNKGDLLDAGVNRSPSSYLNNPAAERSKYKYDVDKEMT 205

Query: 1237 LVKFVDDESGPVGSFNWFATHGTSMSRTNSLISGDNKGAAARFMEDWAEQNGLPKQTGVA 1416
            LVKFVD + GP GSFNWFATHGTSMSRTNSLISGDNKGAAARFMEDW E NG  ++  V+
Sbjct: 206  LVKFVDSQLGPTGSFNWFATHGTSMSRTNSLISGDNKGAAARFMEDWFE-NG--QKNSVS 262

Query: 1417 SSDDLGSLHMTSVLPRRVSTIIPEPDEITDDLMQLASSYEASGGRRLAGS-NITRRIRSS 1593
            S +          +PRRVSTI+ +     D L+ +A++Y++S G  +  S ++  R+R+ 
Sbjct: 263  SRN----------IPRRVSTIVSDFSRNRDRLLDIAATYKSSRGHSVDKSLDVKTRVRNG 312

Query: 1594 QENNAKFVSAFCQSNCGDVSPNVLGTFCIDTHLPCDFNHSTCNGKNELCYGRGPGYPNEF 1773
             +   KFVSAFCQSNCGDVSPN LGTFCIDT LPCDFNHSTCNG+NELCYGRGPGYP+EF
Sbjct: 313  SKR--KFVSAFCQSNCGDVSPNTLGTFCIDTGLPCDFNHSTCNGQNELCYGRGPGYPDEF 370

Query: 1774 ESTRIIGNRQFLKAVDLFNSASEEIQGKIDYRHTYLDFSQLKVSVSTSTGGPQVVKTCXX 1953
            ESTRIIG +QF  AV+LFN A+E++QGKI Y+H YLDFS L V+V  + GG + VKTC  
Sbjct: 371  ESTRIIGEKQFKMAVELFNKATEKLQGKIGYQHAYLDFSNLDVTVPKAGGGSETVKTCPA 430

Query: 1954 XXXXXXXXXXXXXXXXXXFKQGDDKGNPFWRLVRNLLKTPGKEQVECQAPKPILLDTGEM 2133
                              FKQGDD+GN FWRLVRN+L+TPG EQV+CQ PKPILLDTGEM
Sbjct: 431  AMGFGFAAGTTDGPGAFDFKQGDDQGNVFWRLVRNVLRTPGPEQVQCQKPKPILLDTGEM 490

Query: 2134 KEPYDWAPAILPIQIIRIGQLVILCVPGEFTTMAGRRLRDAVKNVLISGSNSEFGTNIHV 2313
            KEPYDWAP+ILPIQI+RIGQLVIL VPGEFTTMAGRRLRDA+K+ LIS    EF  N+HV
Sbjct: 491  KEPYDWAPSILPIQILRIGQLVILSVPGEFTTMAGRRLRDAIKSFLISSDPKEFSNNMHV 550

Query: 2314 VLAGLTNTYSQYVTTFEEYQIQRYEGASTLYGPHTLSAYIQEFQKLATAMIENKEVPTNI 2493
            V+AGLTNTYSQY+ TFEEY++QRYEGASTLYG HTL+AYIQEF+KLATA++    +P   
Sbjct: 551  VIAGLTNTYSQYIATFEEYEVQRYEGASTLYGRHTLTAYIQEFKKLATALVNGLTLPRGP 610

Query: 2494 QPPDMLEKQIGLLPGVMYDSTPRGVHFGDVSSDVAANSNFRKGSTVNATFYSACPRNDLL 2673
            QPPD+L+KQI LL  V+ DSTP GV FGDV +DV   S FR+G  VNATF+S CPRNDL+
Sbjct: 611  QPPDLLDKQISLLSPVVVDSTPLGVKFGDVKADVPPKSTFRRGQQVNATFWSGCPRNDLM 670

Query: 2674 TEGTFALVEKL-NGNNWIPVYDDDDWSLQFKWSRPSKFSPRSFATLEWTIPEDAASGVYR 2850
            TEG+FA+VE L  G  W PVYDDDD+SL+FKWSRP+K S  S AT+EW +PE A +GVYR
Sbjct: 671  TEGSFAVVETLREGGKWAPVYDDDDFSLKFKWSRPAKLSSESQATIEWRVPESAVAGVYR 730

Query: 2851 LRHSGASKPLIGSIKHFTGTSRAFAV 2928
            +RH GASK L GSI  F+G+S AF V
Sbjct: 731  IRHYGASKSLFGSISSFSGSSSAFVV 756

>Q5W7F1:ASAH2_DANRE Neutral ceramidase - Danio rerio (Zebrafish) (Brachydanio rerio)|
          Length = 743

 Score =  451 bits (1160), Expect = e-126
 Identities = 286/759 (37%), Positives = 400/759 (52%), Gaps = 12/759 (1%)
 Frame = +1

Query: 688  DSPYLVGMGSYDITGPAADVNMMGYANTEQIASGIHFRLKSRAFIVAEPNGERVVFVNLD 867
            + PYL+G+G  D TGP AD+ MMGYANT+Q A G+H RL SRAFIV + N +RVVFV  D
Sbjct: 58   EKPYLIGVGRADCTGPVADLPMMGYANTDQTARGLHTRLFSRAFIVDDGN-KRVVFVTSD 116

Query: 868  ACMASQLVNIKVLERLKARYGDLYNENNVAISGIHTHAGPGGYLQYVVYIVTSLGFVRQS 1047
              M SQ + ++V + LK +YGDLY ++NV +SG HTH+G GGY QY ++++TS G+++ S
Sbjct: 117  IGMVSQRLRLEVFQALKEKYGDLYRQDNVVLSGTHTHSGVGGYFQYTLFMITSKGYIKPS 176

Query: 1048 FDVIVDGIEQSIVEAHNNLHPGKIYVNKGDLIDAGVNRSPSAYLNNPAEERSKYKYNVDK 1227
               IV GI +SI  AH NL PG+I++NKG + D+  NRSP +           Y  N ++
Sbjct: 177  IQAIVSGIVKSIDIAHRNLRPGRIFINKGQVADSNFNRSPHS-----------YMNNPEE 225

Query: 1228 EMTLVKFVDDESGPVGSFNWFATHGTSMSRTNSLISGDNKGAAARFMEDWAEQNGLPKQT 1407
            E    +F  D+   V  F              + + GD  G  + F       N   +  
Sbjct: 226  ERNRYEFNTDKQIVVLKF--------------TDLDGDGIGLLSWFAVHPVSMNYTNR-- 269

Query: 1408 GVASSDDLGSLHMTSVLPRRVSTIIPEPDEITDDLMQLASSYEASGGRRLAGSNITRRIR 1587
             + SSD+LG         + +  +  E                                 
Sbjct: 270  -MVSSDNLGYASYIFEQEKNIGFLPGE--------------------------------- 295

Query: 1588 SSQENNAKFVSAFCQSNCGDVSPNVLGTFCIDTHLPCDFNHSTCN-GKNELCYGRGPGYP 1764
                    FV+ F  SN GD SPN+ G  C++T L CD+ +S+C  G  + C   GPG  
Sbjct: 296  -----KGPFVAGFSSSNLGDSSPNIRGPVCVNTGLKCDYINSSCPVGGKKACIAFGPG-E 349

Query: 1765 NEFESTRIIGNRQFLKAVDLFNSASEEIQGKIDYRHTYLDFSQLKVSV-STSTGGPQVVK 1941
            + FESTRIIG   F  A +L+ SA +E+ G +   H +++ +   V   ST TG     +
Sbjct: 350  DMFESTRIIGENMFKIAKELYGSAKQELHGPVYGAHQWVNMTDETVQFNSTHTG-----R 404

Query: 1942 TCXXXXXXXXXXXXXXXXXXXXFKQGDDKGNPFWRLVRN-LLKTPGKEQVECQAPKPILL 2118
            TC                    F QGD +G+PFW  +R+ +L  P  E   C  PKPIL 
Sbjct: 405  TCKPALGHSFAAGTTDGGGEFNFLQGDTEGDPFWDGIRDAVLGPPSNETKACHQPKPILF 464

Query: 2119 DTGEMKEPYDWAPAILPIQIIRIGQLVILCVPGEFTTMAGRRLRDAVKNVLISGSNSEFG 2298
             TGEM  P  W PAI+ +QII IG L ++ VPGEFTTM+GRR+R+AVK  L      E  
Sbjct: 465  STGEMDSPLPWHPAIVDVQIITIGSLAVVAVPGEFTTMSGRRIREAVKREL---EVKEPF 521

Query: 2299 TNIHVVLAGLTNTYSQYVTTFEEYQIQRYEGASTLYGPHTLSAYIQEFQKLATAMIENK- 2475
            TN  VV+AGL N Y+ Y+TT+EEYQIQRYEGAST++GPHTLSAYIQ ++ LA A+     
Sbjct: 522  TNAEVVVAGLCNIYTHYITTYEEYQIQRYEGASTIFGPHTLSAYIQRYRGLAKAIAHGTI 581

Query: 2476 -EVPTNIQPPDMLE-KQIGLLPGVMYDSTPRGVHFGDVSSDVAANSNFRKGSTVNATFYS 2649
             E+P   +PP   E K    +   + D  P G  FGDV  +V  N  ++ G   + TF S
Sbjct: 582  GELPKGPEPPFFDEDKLFNQVRDPVADVAPVGTTFGDVLQEV--NPVYKVGEIASVTFVS 639

Query: 2650 ACPRND-LLTEGTFALVEKLNGN--NWIPVYDDDDWSLQFKWSRPSKFSPRSFATLEWTI 2820
              PR+   + + T   VE+ + +  +W  +++D  W  +F W +    + RS A +EW I
Sbjct: 640  GNPRHSGDIRDTTLVTVERFHNDTGSWEIIHNDASWETRFHWIK--GLAGRSQAKVEWHI 697

Query: 2821 PEDAASGVYRLRHSGASKPLIGS---IKHFTGTSRAFAV 2928
            P+ A +G Y++++ G  K    +   I  + GTS AF V
Sbjct: 698  PQTAQAGTYQIQYFGHYKQTTENTTVITPYVGTSAAFKV 736

>Q55G11:NCSEB_DICDI Neutral ceramidase B precursor - Dictyostelium discoideum (Slime|
            mold)
          Length = 718

 Score =  364 bits (935), Expect = 1e-99
 Identities = 197/446 (44%), Positives = 269/446 (60%), Gaps = 6/446 (1%)
 Frame = +1

Query: 1612 FVSAFCQSNCGDVSPNVLGTFCIDTHLPCDFNHSTCNGKNELCYGRGPGYPNE-FESTRI 1788
            FV+AF QSN GDVSPN  G  C D   PCD+  STCNG+NE C+  GPG   + FEST+I
Sbjct: 285  FVAAFGQSNEGDVSPNTRGPTCRDGS-PCDYKTSTCNGRNEECWSLGPGKDGDMFESTQI 343

Query: 1789 IGNRQFLKAVDLFNSASEEIQGKIDYRHTYLDFSQLKVSVSTSTGGPQVVKTCXXXXXXX 1968
            IG  QF KA++LFN+AS ++ G + YRH+++ F+ + V    ++G      TC       
Sbjct: 344  IGGNQFNKALELFNNASIQVSGPVQYRHSWVQFTNVSVEPPYNSGVDNAT-TCRGAMGYS 402

Query: 1969 XXXXXXXXXXXXXFKQGDDK--GNPFWRLVRNLLKTPGKEQVECQAPKPILLDTGEMKEP 2142
                         F Q D+   GNPFW  + + +  P  +Q+ CQ+PKPILLD G M EP
Sbjct: 403  FAAGTTDGPGAFNFVQSDNNTSGNPFWNFIGDFIAKPTPDQIRCQSPKPILLDVG-MVEP 461

Query: 2143 YDWAPAILPIQIIRIGQLVILCVPGEFTTMAGRRLRDAVKNVLISGSNSEFGTNIHVVLA 2322
              W P ++PIQI+ IGQ+V++ VPGEFTTM+GRRLR++V+ ++  G + E   N  V++A
Sbjct: 462  IPWVPDVMPIQIVTIGQIVLVAVPGEFTTMSGRRLRNSVREII--GESIE---NPIVLIA 516

Query: 2323 GLTNTYSQYVTTFEEYQIQRYEGASTLYGPHTLSAYIQEFQKLATAMIENKEVPTNIQPP 2502
            GL+NTYS Y+ TFEEYQ+QRYEGAST++GPHTL +Y+QEF KLA ++++   VP    P 
Sbjct: 517  GLSNTYSGYIATFEEYQVQRYEGASTVFGPHTLGSYMQEFGKLAQSIVDGTTVPAGPTPR 576

Query: 2503 DMLEKQIGLLPGVMYDSTPRGVHFGDVSSDVAANSNFRKGSTVNATFYSACPRNDLLTEG 2682
            ++    +  LP V+ D+ P    FG+VS DV  N N+    TV+  FY   PRND + E 
Sbjct: 577  NLTGHTLFFLPPVIVDAAPDFDDFGEVSIDV--NLNYSVNETVSCVFYGGNPRNDFMIES 634

Query: 2683 TFALVEKLNG-NNWIPVYDDDDWSLQFKWSRPSKFSPRSFATLEWTIPEDAASGVYRLRH 2859
            +F  V+ L G + W  V DD DW  +FKW         S  T+EW I  D   G YR+ H
Sbjct: 635  SFLSVDLLTGTDQWTTVLDDGDWDTKFKWKMHD--LGFSLITIEWVIAPDTTPGTYRITH 692

Query: 2860 SGASK--PLIGSIKHFTGTSRAFAVR 2931
            SG +K  P   ++  + G SR F V+
Sbjct: 693  SGFAKKNPFSSNLTPYQGISRNFVVQ 718



 Score =  236 bits (603), Expect = 3e-61
 Identities = 116/242 (47%), Positives = 163/242 (67%), Gaps = 1/242 (0%)
 Frame = +1

Query: 688  DSPYLVGMGSYDITGPAADVNMMGYANTEQIASGIHFRLKSRAFIVAEPNGERVVFVNLD 867
            DS Y +G G YDITG +A+VN+MGYAN  Q+ +GIHFR ++RAF+  + NG R V+V+ D
Sbjct: 43   DSSYQIGAGIYDITGASAEVNLMGYANPLQVGAGIHFRQRARAFVFVDSNGNRAVYVSTD 102

Query: 868  ACMASQLVNIKVLERLKARYG-DLYNENNVAISGIHTHAGPGGYLQYVVYIVTSLGFVRQ 1044
            +CM  Q V I V+E L+  +G ++Y E NV +SG HTH+GP G+ QY +Y +TSLGF ++
Sbjct: 103  SCMIFQEVKIHVVELLQDIFGPNVYTEANVLLSGTHTHSGPAGFSQYALYGITSLGFYKK 162

Query: 1045 SFDVIVDGIEQSIVEAHNNLHPGKIYVNKGDLIDAGVNRSPSAYLNNPAEERSKYKYNVD 1224
            +FD I +GI Q+IV+AH ++ P  ++   G+L +  +NRSP AY NNP EE++ Y  NVD
Sbjct: 163  NFDTICNGIVQAIVKAHKSVQPANMFTETGELWNTNINRSPFAYDNNPEEEKAMYDSNVD 222

Query: 1225 KEMTLVKFVDDESGPVGSFNWFATHGTSMSRTNSLISGDNKGAAARFMEDWAEQNGLPKQ 1404
            K MT+++  D    P  + ++FA H TSM+ TN LISGDNKG A+     W +Q   P  
Sbjct: 223  KNMTVLRIEDMNGNPFAAISFFAVHCTSMNNTNHLISGDNKGYASYL---WEKQVNGPGT 279

Query: 1405 TG 1410
             G
Sbjct: 280  AG 281

>Q54BK2:NCSEA_DICDI Neutral ceramidase A precursor - Dictyostelium discoideum (Slime|
            mold)
          Length = 714

 Score =  340 bits (872), Expect = 2e-92
 Identities = 188/454 (41%), Positives = 262/454 (57%), Gaps = 5/454 (1%)
 Frame = +1

Query: 1585 RSSQENNAKFVSAFCQSNCGDVSPNVLGTFCIDTHLPCDFNHSTCNGKNELCYGRGPGYP 1764
            +SS      F++AF QSN GDVSPN  G  C D   PCD+  STCNGK E C+  GPG  
Sbjct: 271  QSSLPGTGPFIAAFGQSNEGDVSPNTRGPTCRDGK-PCDYKTSTCNGKVEECWALGPGTD 329

Query: 1765 NE-FESTRIIGNRQFLKAVDLFNSASEEIQGKIDYRHTYLDFSQLKVSVSTSTGGPQVVK 1941
             + FEST+IIG  QF KA++LFN+A+ ++ GKI YRHT+  F+ + V    ++G  +   
Sbjct: 330  GDMFESTQIIGGNQFNKALELFNNATIQVSGKIQYRHTWKPFTNVSVEAPYNSG-VEGAT 388

Query: 1942 TCXXXXXXXXXXXXXXXXXXXXFKQGDDKG-NPFWRLVRNLLKTPGKEQVECQAPKPILL 2118
            TC                    F QGD+   NPFW  +  ++  P  +Q  CQAPKPIL+
Sbjct: 389  TCRGAMGYSFAGGTTDGPGAFNFIQGDNSTTNPFWNFIGGIIAKPTPQQTACQAPKPILI 448

Query: 2119 DTGEMKEPYDWAPAILPIQIIRIGQLVILCVPGEFTTMAGRRLRDAVKNVLISGSNSEFG 2298
            D G M EP  W P ++P+QII +GQ+V++ VPGEFTTM+GRRLR+ V+ ++  G + E  
Sbjct: 449  DVG-MVEPIPWVPDVMPLQIITLGQIVLVAVPGEFTTMSGRRLRNTVREII--GQSIE-- 503

Query: 2299 TNIHVVLAGLTNTYSQYVTTFEEYQIQRYEGASTLYGPHTLSAYIQEFQKLATAMIENKE 2478
             N  V++AGL NTYS Y+ TFEE+Q+QRYEGAST++GPHTL AY QEF  LA ++++  +
Sbjct: 504  -NPIVLIAGLANTYSGYIATFEEFQVQRYEGASTVFGPHTLGAYQQEFANLAQSIVDGSQ 562

Query: 2479 VPTNIQPPDMLEKQIGLLPGVMYDSTPRGVHFGDVSSDVAANSNFRKGSTVNATFYSACP 2658
                  P +M       LP V+ D  P+   FGD+ +DV+  + +    TV   FY A  
Sbjct: 563  ADPGTFPRNMSGHTPFFLPPVIVDVAPKFDDFGDIYTDVSTTTPYSINQTVTVIFYGANL 622

Query: 2659 RNDLLTEGTFALVEKLNGN-NWIPVYDDDDWSLQFKWSRPSKFSPRSFATLEWTIPEDAA 2835
            RN+ +TE +F  V++L  N  W  + +D DW  +  W         S  T++WTI     
Sbjct: 623  RNNFMTESSFLTVDQLQSNGQWTTILNDGDWDTKLYWKMHD--LGFSLITVDWTISPITQ 680

Query: 2836 SGVYRLRHSGASK--PLIGSIKHFTGTSRAFAVR 2931
             G YR+ HSG +K  P   ++  + G S  F V+
Sbjct: 681  PGTYRITHSGYAKKNPFSDNLTFYQGISSNFNVQ 714



 Score =  235 bits (600), Expect = 7e-61
 Identities = 115/247 (46%), Positives = 164/247 (66%), Gaps = 2/247 (0%)
 Frame = +1

Query: 664  QNCTPVLSDSPYLVGMGSYDITGPAADVNMMGYANTEQIASGIHFRLKSRAFIVAEPNGE 843
            +N   +  DS Y +G G YDITGP A+ NMMGYA   QI  GIHFR ++RAF+  +  G 
Sbjct: 29   ENHIKLSDDSSYQIGTGIYDITGPGAETNMMGYAMPGQITGGIHFRQRARAFVFIDSEGN 88

Query: 844  RVVFVNLDACMASQLVNIKVLERLKARYGD-LYNENNVAISGIHTHAGPGGYLQYVVYIV 1020
            R V+V+ D+CM  Q V I+V++ L+  +G  LY  +NV +SG HTH+GP G+ +Y +Y +
Sbjct: 89   RAVYVSTDSCMIFQEVKIQVIQDLQEIFGPTLYTHDNVLLSGTHTHSGPAGFSEYALYGI 148

Query: 1021 TSLGFVRQSFDVIVDGIEQSIVEAHNNLHPGKIYVNKGDLIDAGVNRSPSAYLNNPAEER 1200
            T+LGF +++FD I DGI Q+IV+AH ++ P ++   +G+L ++ +NRSP AY NNP EE+
Sbjct: 149  TALGFYKKNFDTICDGIVQAIVKAHKSVQPARMLTQQGELWNSNINRSPYAYDNNPEEEK 208

Query: 1201 SKYKYNVDKEMTLVKFVDDESGPVGSFNWFATHGTSMSRTNSLISGDNKGAAARFMEDWA 1380
            + Y  NVDK MT+++  D    P  + ++F  H TSM+ TN LISGDNKG A+   E  A
Sbjct: 209  AMYDANVDKNMTVIRIEDMSGNPFAAISFFGVHCTSMNNTNHLISGDNKGYASYLWEKHA 268

Query: 1381 E-QNGLP 1398
              Q+ LP
Sbjct: 269  NGQSSLP 275

>Q9NR71:ASAH2_HUMAN Neutral ceramidase - Homo sapiens (Human)|
          Length = 780

 Score =  301 bits (770), Expect = 1e-80
 Identities = 182/453 (40%), Positives = 254/453 (56%), Gaps = 14/453 (3%)
 Frame = +1

Query: 1612 FVSAFCQSNCGDVSPNVLGTFCIDTHLPCDFNHSTCN-GKNELCYGRGPGYPNEFESTRI 1788
            FV+AF  SN GDVSPN+LG  CI+T   CD  +STC  G   +C  +GPG  + F+ST+I
Sbjct: 341  FVAAFASSNLGDVSPNILGPRCINTGESCDNANSTCPIGGPSMCIAKGPGQ-DMFDSTQI 399

Query: 1789 IGNRQFLKAVDLFNSASEEIQGKIDYRHTYLDFSQLKVSVSTSTGGPQVVKTCXXXXXXX 1968
            IG   + +A +L+ SAS+E+ G +   H ++D + + V ++++       KTC       
Sbjct: 400  IGRAMYQRAKELYASASQEVTGPLASAHQWVDMTDVTVWLNSTHAS----KTCKPALGYS 455

Query: 1969 XXXXXXXXXXXXXFKQGDDKGNPFWRLVRN-LLKTPGKEQVECQAPKPILLDTGEMKEPY 2145
                         F QG  +G+PFW  +R+ +L  P +E  EC  PKPILL TGE+ +P+
Sbjct: 456  FAAGTIDGVGGLNFTQGKTEGDPFWDTIRDQILGKPSEEIKECHKPKPILLHTGELSKPH 515

Query: 2146 DWAPAILPIQIIRIGQLVILCVPGEFTTMAGRRLRDAVKNVLISGSNSEFGTNIHVVLAG 2325
             W P I+ +QII +G L I  +PGEFTTM+GRRLR+AV+    S        N+ VV++G
Sbjct: 516  PWHPDIVDVQIITLGSLAITAIPGEFTTMSGRRLREAVQAEFASHGMQ----NMTVVISG 571

Query: 2326 LTNTYSQYVTTFEEYQIQRYEGASTLYGPHTLSAYIQEFQKLATAMIEN--KEVPTNIQP 2499
            L N Y+ Y+TT+EEYQ QRYE AST+YGPHTLSAYIQ F+ LA A+  +    +    +P
Sbjct: 572  LCNVYTHYITTYEEYQAQRYEAASTIYGPHTLSAYIQLFRNLAKAIATDTVANLSRGPEP 631

Query: 2500 PDMLEKQIGLLPGVMYDSTPRGVHFGDVSSDVAANSNFRKGSTVNATFYSACPRNDL--L 2673
            P   +  + L+P ++ D  P+G  FGDV     A   +R G      F  A P+N +   
Sbjct: 632  PFFKQLIVPLIPSIV-DRAPKGRTFGDVLQ--PAKPEYRVGEVAEVIFVGANPKNSVQNQ 688

Query: 2674 TEGTFALVEK--LNGNNWIPVYDDDDWSLQFKWSRPSKFSPRSFATLEWTIPEDAASGVY 2847
            T  TF  VEK      +W  V +D  W  +F W +       S AT+EW IP+ A  G+Y
Sbjct: 689  THQTFLTVEKYEATSTSWQIVCNDASWETRFYWHK--GLLGLSNATVEWHIPDTAQPGIY 746

Query: 2848 RLRHSGAS------KPLIGSIKHFTGTSRAFAV 2928
            R+R+ G +      KP +  I  F GTS AF V
Sbjct: 747  RIRYFGHNRKQDILKPAV--ILSFEGTSPAFEV 777



 Score =  235 bits (599), Expect = 1e-60
 Identities = 120/266 (45%), Positives = 170/266 (63%), Gaps = 4/266 (1%)
 Frame = +1

Query: 691  SPYLVGMGSYDITGPAADVNMMGYANTEQIASGIHFRLKSRAFIVAEPNGE-RVVFVNLD 867
            S Y +G+G  D TG  AD+N+MGY  + Q A GI  RL SRAFI+AEP+G  R VFV++D
Sbjct: 100  SGYHIGVGRADCTGQVADINLMGYGKSGQNAQGILTRLYSRAFIMAEPDGSNRTVFVSID 159

Query: 868  ACMASQLVNIKVLERLKARYGDLYNENNVAISGIHTHAGPGGYLQYVVYIVTSLGFVRQS 1047
              M SQ + ++VL RL+++YG LY  +NV +SG HTH+GP GY QY V+++ S GF  Q+
Sbjct: 160  IGMVSQRLRLEVLNRLQSKYGSLYRRDNVILSGTHTHSGPAGYFQYTVFVIASEGFSNQT 219

Query: 1048 FDVIVDGIEQSIVEAHNNLHPGKIYVNKGDLIDAGVNRSPSAYLNNPAEERSKYKYNVDK 1227
            F  +V GI +SI  AH N+ PGKI++NKG++    +NRSP +YL NP  ER++Y  N DK
Sbjct: 220  FQHMVTGILKSIDIAHTNMKPGKIFINKGNVDGVQINRSPYSYLQNPQSERARYSSNTDK 279

Query: 1228 EMTLVKFVDDESGPVGSFNWFATHGTSMSRTNSLISGDNKGAAARFMEDWAEQNGLPKQ- 1404
            EM ++K VD     +G  +WFA H  SM+ +N L++ DN G A+  +E    +  LP Q 
Sbjct: 280  EMIVLKMVDLNGDDLGLISWFAIHPVSMNNSNHLVNSDNVGYASYLLEQEKNKGYLPGQG 339

Query: 1405 --TGVASSDDLGSLHMTSVLPRRVST 1476
                  +S +LG +    + PR ++T
Sbjct: 340  PFVAAFASSNLGDVSPNILGPRCINT 365

>Q9JHE3:ASAH2_MOUSE Neutral ceramidase - Mus musculus (Mouse)|
          Length = 756

 Score =  294 bits (753), Expect = 1e-78
 Identities = 181/457 (39%), Positives = 250/457 (54%), Gaps = 18/457 (3%)
 Frame = +1

Query: 1612 FVSAFCQSNCGDVSPNVLGTFCIDTHLPCDFNHSTC-NGKNELCYGRGPGYPNEFESTRI 1788
            FV+ F  SN GDVSPN+LG  C++T   CD + STC NG   +C   GPG  + FEST I
Sbjct: 317  FVAGFASSNLGDVSPNILGPHCVNTGESCDNDKSTCPNGGPSMCMASGPGQ-DMFESTHI 375

Query: 1789 IGNRQFLKAVDLFNSASEEIQGKIDYRHTYLDFSQLKVSVSTSTGGPQVVKTCXXXXXXX 1968
            IG   + KA +L+ SAS+E+ G +   H +++ + + V ++ +      VKTC       
Sbjct: 376  IGRIIYQKAKELYASASQEVTGPVLAAHQWVNMTDVSVQLNAT----HTVKTCKPALGYS 431

Query: 1969 XXXXXXXXXXXXXFKQGDDKGNPFWRLVRN-LLKTPGKEQVECQAPKPILLDTGEMKEPY 2145
                           QG  +G+PFW  +R+ LL  P +E VECQ PKPILL +GE+  P+
Sbjct: 432  FAAGTIDGVSGLNITQGTTEGDPFWDTLRDQLLGKPSEEIVECQKPKPILLHSGELTIPH 491

Query: 2146 DWAPAILPIQIIRIGQLVILCVPGEFTTMAGRRLRDAVKNVLISGSNSEFG----TNIHV 2313
             W P I+ +QI+ +G L I  +PGE TTM+GRR R+A+K         EF      ++ V
Sbjct: 492  PWQPDIVDVQIVTVGSLAIAAIPGELTTMSGRRFREAIK--------KEFALYGMKDMTV 543

Query: 2314 VLAGLTNTYSQYVTTFEEYQIQRYEGASTLYGPHTLSAYIQEFQKLATAMIEN--KEVPT 2487
            V+AGL+N Y+ Y+TT+EEYQ QRYE AST+YGPHTLSAYIQ F+ LA A+  +    + +
Sbjct: 544  VIAGLSNVYTHYITTYEEYQAQRYEAASTIYGPHTLSAYIQLFRDLAKAIATDTVANMSS 603

Query: 2488 NIQPPDMLEKQIGLLPGVMYDSTPRGVHFGDVSSDVAANSNFRKGSTVNATFYSACPRN- 2664
              +PP        L+P +  D  P G HFGDV     A   +R G  V   F  A P+N 
Sbjct: 604  GPEPPFFKNLIASLIPNIA-DRAPIGKHFGDVLQ--PAKPEYRVGEVVEVIFVGANPKNS 660

Query: 2665 -DLLTEGTFALVEKLNGN--NWIPVYDDDDWSLQFKWSRPSKFSPRSFATLEWTIPEDAA 2835
             +  T  TF  VEK   +  +W  +Y+D  W  +F W +       S AT+ W IP+ A 
Sbjct: 661  AENQTHQTFLTVEKYEDSVADWQIMYNDASWETRFYWHK--GILGLSNATIYWHIPDTAY 718

Query: 2836 SGVYRLRHSGAS------KPLIGSIKHFTGTSRAFAV 2928
             G+YR+R+ G +      KP +  I  F G S  F V
Sbjct: 719  PGIYRIRYFGHNRKQELLKPAV--ILAFEGISSPFEV 753



 Score =  233 bits (595), Expect = 3e-60
 Identities = 121/267 (45%), Positives = 172/267 (64%), Gaps = 5/267 (1%)
 Frame = +1

Query: 691  SPYLVGMGSYDITGPAADVNMMGYANTEQIASGIHFRLKSRAFIVAEPNGE-RVVFVNLD 867
            S Y +G+G  D TG  +D+N+MGY    Q A G+  RL SRAFI+A+P+G  R+ FV+++
Sbjct: 76   SGYYIGVGRADCTGQVSDINLMGYGKNGQNARGLLTRLFSRAFILADPDGSNRMAFVSVE 135

Query: 868  ACMASQLVNIKVLERLKARYGDLYNENNVAISGIHTHAGPGGYLQYVVYIVTSLGFVRQS 1047
             CM SQ + ++VL+RL+++YG LY  +NV +S IHTH+GP G+ QY +YI+ S GF  ++
Sbjct: 136  LCMISQRLRLEVLKRLESKYGSLYRRDNVILSAIHTHSGPAGFFQYTLYILASEGFSNRT 195

Query: 1048 FDVIVDGIEQSIVEAHNNLHPGKIYVNKGDLIDAGVNRSPSAYLNNPAEERSKYKYNVDK 1227
            F  IV GI +SI  AH NL PGKI++NKG++ +  +NRSPS+YL NP  ER++Y  N DK
Sbjct: 196  FQYIVSGIMKSIDIAHTNLKPGKIFINKGNVANVQINRSPSSYLLNPQSERARYSSNTDK 255

Query: 1228 EMTLVKFVDDESGPVGSFNWFATHGTSMSRTNSLISGDNKGAAARFMEDWAEQNGLPKQ- 1404
            EM ++K VD     +G  +WFA H  SM+ +N  ++ DN G AA   E    +  LP Q 
Sbjct: 256  EMLVLKLVDLNGEDLGLISWFAIHPVSMNNSNHFVNSDNMGYAAYLFEQEKNKGYLPGQG 315

Query: 1405 ---TGVASSDDLGSLHMTSVLPRRVST 1476
                G ASS +LG +    + P  V+T
Sbjct: 316  PFVAGFASS-NLGDVSPNILGPHCVNT 341

>Q91XT9:ASAH2_RAT Neutral ceramidase - Rattus norvegicus (Rat)|
          Length = 761

 Score =  294 bits (752), Expect = 2e-78
 Identities = 183/456 (40%), Positives = 249/456 (54%), Gaps = 17/456 (3%)
 Frame = +1

Query: 1612 FVSAFCQSNCGDVSPNVLGTFCIDTHLPCDFNHSTC-NGKNELCYGRGPGYPNEFESTRI 1788
            FV+ F  SN GDVSPN+LG  C++T   CD + STC +G   +C   GPG  + FEST I
Sbjct: 322  FVAGFASSNLGDVSPNILGPHCVNTGESCDNDKSTCPSGGPSMCMASGPGQ-DMFESTHI 380

Query: 1789 IGNRQFLKAVDLFNSASEEIQGKIDYRHTYLDFSQLKVSVSTSTGGPQVVKTCXXXXXXX 1968
            IG   + KA +L  SAS+E+ G +   H +++ + + V ++ +      VKTC       
Sbjct: 381  IGRVIYQKAKELHASASQEVTGPVLTAHQWVNMTDVSVQLNAT----HTVKTCKAALGYS 436

Query: 1969 XXXXXXXXXXXXXFKQGDDKGNPFWRLVRN-LLKTPGKEQVECQAPKPILLDTGEMKEPY 2145
                           QG  +GN FW  +R+ LL  P +E +ECQ PKPIL+ TGE+ +P+
Sbjct: 437  FAAGTIDGVSGLNITQGTTEGNLFWDTLRDQLLGKPSEEIIECQKPKPILIHTGELTKPH 496

Query: 2146 DWAPAILPIQIIRIGQLVILCVPGEFTTMAGRRLRDAVKNVLISGSNSEFG----TNIHV 2313
             W P I+ IQI+ +G L I  +PGEFTTM+GRRLR+AVK         EF      ++ V
Sbjct: 497  PWQPDIVDIQIVTLGSLAIAAIPGEFTTMSGRRLREAVK--------KEFALYGMKDMTV 548

Query: 2314 VLAGLTNTYSQYVTTFEEYQIQRYEGASTLYGPHTLSAYIQEFQKLATAMIENKEVPTNI 2493
            V+AGL+N Y+ Y+TT+EEYQ QRYE AST+YGPHTLSAYIQ F+ LA A+  +     + 
Sbjct: 549  VIAGLSNVYTHYITTYEEYQAQRYEAASTIYGPHTLSAYIQLFRALAKAIATDTVANMSS 608

Query: 2494 QP-PDMLEKQIGLLPGVMYDSTPRGVHFGDVSSDVAANSNFRKGSTVNATFYSACPRN-- 2664
             P P   +  IG L   + D  P G  FGDV     A   +R G  V   F  A P+N  
Sbjct: 609  GPEPPFFKNLIGSLIPNIADRAPIGKQFGDVLQ--PAKPEYRVGEVVEVVFVGANPKNSA 666

Query: 2665 DLLTEGTFALVEKLNGN--NWIPVYDDDDWSLQFKWSRPSKFSPRSFATLEWTIPEDAAS 2838
            +  T  TF  VEK   +  NW  +++D  W  +F W +       S AT+ W IP+ A  
Sbjct: 667  ENQTHQTFLTVEKYEDSVANWQIMHNDASWETRFYWHK--GVLGLSNATIHWHIPDTALP 724

Query: 2839 GVYRLRHSGAS------KPLIGSIKHFTGTSRAFAV 2928
            GVYR+R+ G +      KP +  I  F G S  F +
Sbjct: 725  GVYRIRYFGHNRKQELLKPAV--ILAFEGISSPFEI 758



 Score =  232 bits (591), Expect = 8e-60
 Identities = 120/272 (44%), Positives = 173/272 (63%), Gaps = 5/272 (1%)
 Frame = +1

Query: 676  PVLSDSPYLVGMGSYDITGPAADVNMMGYANTEQIASGIHFRLKSRAFIVAEPNGE-RVV 852
            P  + S Y +G+G  D TG  +D+N+MGY    Q A G+  RL SRAFI+A+P+G  R+ 
Sbjct: 76   PSQNFSGYYIGVGRADCTGQVSDINLMGYGKNGQNAQGLLTRLFSRAFILADPDGSNRMA 135

Query: 853  FVNLDACMASQLVNIKVLERLKARYGDLYNENNVAISGIHTHAGPGGYLQYVVYIVTSLG 1032
            FV+++ CM SQ + ++VL+RL+++YG LY  +NV +S  HTH+GP G+ QY +YI+ S G
Sbjct: 136  FVSVELCMISQRLRLEVLKRLQSKYGSLYRRDNVILSATHTHSGPAGFFQYTLYILASEG 195

Query: 1033 FVRQSFDVIVDGIEQSIVEAHNNLHPGKIYVNKGDLIDAGVNRSPSAYLNNPAEERSKYK 1212
            F  ++F  IV GI +SI  AH NL PGK+ +NKG++ +  +NRSPS+YL NP  ER++Y 
Sbjct: 196  FSNRTFQYIVSGIVKSIDIAHTNLKPGKVLINKGNVANVQINRSPSSYLQNPPSERARYS 255

Query: 1213 YNVDKEMTLVKFVDDESGPVGSFNWFATHGTSMSRTNSLISGDNKGAAARFMEDWAEQNG 1392
             + DKEM ++K VD     +G  +WFA H  SM+ +N L++ DN G AA   E    +  
Sbjct: 256  SDTDKEMVVLKLVDLNGEDLGLISWFAVHPVSMNNSNHLVNSDNMGYAAYLFEQEKNRGY 315

Query: 1393 LPKQ----TGVASSDDLGSLHMTSVLPRRVST 1476
            LP Q     G ASS +LG +    + P  V+T
Sbjct: 316  LPGQGPFVAGFASS-NLGDVSPNILGPHCVNT 346

>Q9VA70:NCASE_DROME Neutral ceramidase precursor - Drosophila melanogaster (Fruit fly)|
          Length = 704

 Score =  291 bits (746), Expect = 9e-78
 Identities = 163/448 (36%), Positives = 231/448 (51%), Gaps = 7/448 (1%)
 Frame = +1

Query: 1609 KFVSAFCQSNCGDVSPNVLGTFCIDTHLPCDFNHSTCNGKNELCYGRGPGYPNEFESTRI 1788
            KFV AFC SN GDVSPN++G  C  +   CD   S C      C+  GPG  + FEST+I
Sbjct: 262  KFVGAFCSSNLGDVSPNIMGPKCSISGNECDLLTSRCPTGEGDCFASGPG-KDMFESTQI 320

Query: 1789 IGNRQFLKAVDLFNSASEE-----IQGKIDYRHTYLDFSQLKVSVSTSTGGP-QVVKTCX 1950
            +G R    A+ L N  S+E     + G + + H ++D      S           ++ C 
Sbjct: 321  LGQRLADAALGLLNEQSQESTAREVTGDVRFIHQFVDMPNYNGSTYNPLSRKVDKIRGCQ 380

Query: 1951 XXXXXXXXXXXXXXXXXXXFKQGDDKGNPFWRLVRNLLKTPGKEQVECQAPKPILLDTGE 2130
                               F+QG    NP W  VR+ +  P +E ++C  PKPILL TG 
Sbjct: 381  PAMGYSFAAGTTDGPGAFSFEQGTTTDNPMWNFVRDFIAAPTQEDIKCHEPKPILLATGR 440

Query: 2131 MKEPYDWAPAILPIQIIRIGQLVILCVPGEFTTMAGRRLRDAVKNVLISGSNSEFGTNIH 2310
               PY+W P I+  Q+++IG ++I  VP EFTTMAGRRLR+ ++    + +++  G +  
Sbjct: 441  ATFPYEWQPKIVSDQLLKIGDVIIAAVPCEFTTMAGRRLRNQIR----AAASAVGGIDTE 496

Query: 2311 VVLAGLTNTYSQYVTTFEEYQIQRYEGASTLYGPHTLSAYIQEFQKLATAMIENKEVPTN 2490
            V++AGLTN Y+ Y  T EEYQ QRYE AST++GPHT S Y+  F++L  AM+ N+ V   
Sbjct: 497  VIIAGLTNIYTSYTVTPEEYQAQRYEAASTIFGPHTHSIYMDVFERLTKAMMRNETVDAG 556

Query: 2491 IQPPDMLEKQIGLLPGVMYDSTPRGVHFGDVSSDVAANSNFRKGSTVNATFYSACPRNDL 2670
              PP M +  + L  GV++D  P    FG V S    N  +    TV  T+ S  PRN+L
Sbjct: 557  PSPPYMNDVMLSLNTGVLFDGHPINTDFGYVKSQ--PNKEYGINETVKVTYISGNPRNNL 614

Query: 2671 LTEGTFALVE-KLNGNNWIPVYDDDDWSLQFKWSRPSKFSPRSFATLEWTIPEDAASGVY 2847
             TE T+  +E K+N + W   Y D  W  +  W R +     S   + W I      G Y
Sbjct: 615  FTEKTYFTIERKINEDRWKVAYTDASWETKMVWHRTNTILGFSEMDIYWDISPQTLPGEY 674

Query: 2848 RLRHSGASKPLIGSIKHFTGTSRAFAVR 2931
            R+RHSG  K ++G    + G + +F V+
Sbjct: 675  RIRHSGEYKYILGGKYPYEGLTHSFTVK 702



 Score =  241 bits (614), Expect = 2e-62
 Identities = 132/328 (40%), Positives = 201/328 (61%), Gaps = 15/328 (4%)
 Frame = +1

Query: 682  LSDSPYLVGMGSYDITGPAADVNMMGYANTEQIASGIHFRLKSRAFIVAEPNGERVVFVN 861
            L  + Y VG+G  DITGP  ++N MGYAN +Q+  GIH R+ +RAF+V +  G RV FV+
Sbjct: 20   LVSATYKVGVGRADITGPPVEINFMGYANIKQVGRGIHTRVFARAFVVEDEKGNRVAFVS 79

Query: 862  LDACMASQLVNIKVLERLKARYGDLYNENNVAISGIHTHAGPGGYLQYVVYIVTSLGFVR 1041
             DA M    +  +V++RL+ARYG++Y+ +NVAISG HTH  PGG+L +++Y ++ LGFV 
Sbjct: 80   ADAGMMGYGLKREVIKRLQARYGNIYHNDNVAISGTHTHGAPGGFLMHLLYDISILGFVP 139

Query: 1042 QSFDVIVDGIEQSIVEAHNNLHPGKIYVNKGDLIDAGVNRSPSAYLNNPAEERSKYKYNV 1221
            Q+F+V+  G+   I  A +NL  G+I ++K  +++  +NRSPS+YL NPAEER++Y+++ 
Sbjct: 140  QTFEVMAQGLYLCIKRATDNLVDGRILLSKTTVLNVNINRSPSSYLRNPAEERAQYEHDT 199

Query: 1222 DKEMTLVKFVDDESGPVGSFNWFATHGTSMSRTNSLISGDNKGAAARFMEDWAEQNGLP- 1398
            DK +T ++FVD E+  +G+FNW+A H TSM+ TN L++ DN G AA  +E     N +P 
Sbjct: 200  DKTLTQLRFVDLENNLLGAFNWYAVHATSMNNTNRLVTSDNVGYAALLLEKEYNPNKMPG 259

Query: 1399 --KQTGVASSDDLGSLHMTSVLPRRVSTIIPEPDEITDDLMQLASSYEASG--------- 1545
              K  G   S +LG +   +++  + S    E D +T           ASG         
Sbjct: 260  KGKFVGAFCSSNLGDV-SPNIMGPKCSISGNECDLLTSRCPTGEGDCFASGPGKDMFEST 318

Query: 1546 ---GRRLAGSNITRRIRSSQENNAKFVS 1620
               G+RLA + +      SQE+ A+ V+
Sbjct: 319  QILGQRLADAALGLLNEQSQESTAREVT 346

>Q29C43:NCASE_DROPS Neutral ceramidase precursor - Drosophila pseudoobscura (Fruit fly)|
          Length = 704

 Score =  291 bits (744), Expect = 1e-77
 Identities = 163/448 (36%), Positives = 231/448 (51%), Gaps = 7/448 (1%)
 Frame = +1

Query: 1609 KFVSAFCQSNCGDVSPNVLGTFCIDTHLPCDFNHSTCNGKNELCYGRGPGYPNEFESTRI 1788
            KFV AFC SN GDVSPN++G  C  +   CD   S C      C+  GPG  +  EST+I
Sbjct: 262  KFVGAFCSSNLGDVSPNIMGPKCSISGNECDLLTSRCPAGEGECFASGPGR-DMVESTQI 320

Query: 1789 IGNRQFLKAVDLFNSASEE-----IQGKIDYRHTYLDFSQLKVSVSTSTGGP-QVVKTCX 1950
            +G R    A+ L N  S+E     + G + + H ++D      S           ++ C 
Sbjct: 321  LGQRLADAALGLLNEQSQESTAREVTGDVRFIHQFVDMPNYNGSAYNPLSRKIDKIRGCQ 380

Query: 1951 XXXXXXXXXXXXXXXXXXXFKQGDDKGNPFWRLVRNLLKTPGKEQVECQAPKPILLDTGE 2130
                               F+QG    NP W  VR+ + TP +E ++C  PKPILL TG 
Sbjct: 381  PAMGYSFAAGTTDGPGAFSFEQGTTTDNPMWNFVRDFIATPTQEDIKCHEPKPILLATGR 440

Query: 2131 MKEPYDWAPAILPIQIIRIGQLVILCVPGEFTTMAGRRLRDAVKNVLISGSNSEFGTNIH 2310
               PY+W P I+  Q+++IG ++I  VP EFTTMAGRRLR+ ++    + +++  G +  
Sbjct: 441  ATFPYEWQPKIVSDQLLKIGDVIIAAVPCEFTTMAGRRLRNQIR----AAASAAGGLDTE 496

Query: 2311 VVLAGLTNTYSQYVTTFEEYQIQRYEGASTLYGPHTLSAYIQEFQKLATAMIENKEVPTN 2490
            V++AGLTN Y+ Y  T EEYQ QRYE AST++GPHT S Y+  F++L  A++ N+ V   
Sbjct: 497  VIIAGLTNIYTSYTVTPEEYQAQRYEAASTIFGPHTHSIYMDVFERLTKALMRNETVEPG 556

Query: 2491 IQPPDMLEKQIGLLPGVMYDSTPRGVHFGDVSSDVAANSNFRKGSTVNATFYSACPRNDL 2670
              PP M +  + L  GV++D  P    FG V +       +    TV  T+ S  PRN+L
Sbjct: 557  PSPPYMNDVMLSLNTGVLFDGHPINTDFGYVKTQ--PEKEYGINDTVKVTYISGNPRNNL 614

Query: 2671 LTEGTFALVE-KLNGNNWIPVYDDDDWSLQFKWSRPSKFSPRSFATLEWTIPEDAASGVY 2847
             TE T+  VE K+N + W   Y D  W  +  W R +     S   + W I      GVY
Sbjct: 615  FTEKTYFTVERKINEDRWKVAYTDASWETKMIWHRTNTILGFSDLEIYWNISPQTLPGVY 674

Query: 2848 RLRHSGASKPLIGSIKHFTGTSRAFAVR 2931
            R+RHSG  K ++G    + G S +F V+
Sbjct: 675  RIRHSGEYKYILGGKYPYEGLSHSFTVK 702



 Score =  241 bits (614), Expect = 2e-62
 Identities = 131/328 (39%), Positives = 202/328 (61%), Gaps = 15/328 (4%)
 Frame = +1

Query: 682  LSDSPYLVGMGSYDITGPAADVNMMGYANTEQIASGIHFRLKSRAFIVAEPNGERVVFVN 861
            L+ + Y VG+G  DITGP  ++N MGYAN +Q+  GIH R+ +RAF+V +  G RV FV+
Sbjct: 20   LASATYKVGVGRADITGPPVEINFMGYANIKQVGRGIHTRVFARAFVVEDEKGNRVAFVS 79

Query: 862  LDACMASQLVNIKVLERLKARYGDLYNENNVAISGIHTHAGPGGYLQYVVYIVTSLGFVR 1041
             DA M    +  +V++RL+ARYG+LY+ +NVAISG HTH  PGG+L +++Y ++ LGFV 
Sbjct: 80   ADAGMMGYGLKREVIKRLQARYGNLYHTDNVAISGTHTHGAPGGFLMHLLYDISILGFVP 139

Query: 1042 QSFDVIVDGIEQSIVEAHNNLHPGKIYVNKGDLIDAGVNRSPSAYLNNPAEERSKYKYNV 1221
            Q+F+V+  G+   I  A +NL  G+I+++K  +++  +NRSP++YL NP EER++Y+++ 
Sbjct: 140  QTFEVMAQGLYLCIKRATDNLVDGRIFLSKTTVLNVNINRSPTSYLRNPEEERAQYEHDT 199

Query: 1222 DKEMTLVKFVDDESGPVGSFNWFATHGTSMSRTNSLISGDNKGAAARFMEDWAEQNGLP- 1398
            DK +T ++FVD E+  +G+FNW+A H TSM+ TN L++ DN G AA  +E     N +P 
Sbjct: 200  DKTLTQLRFVDLENNLLGAFNWYAVHATSMNNTNRLVTSDNVGYAALLLEKEYNPNKMPG 259

Query: 1399 --KQTGVASSDDLGSLHMTSVLPRRVSTIIPEPDEITDDLMQLASSYEASG--------- 1545
              K  G   S +LG +   +++  + S    E D +T           ASG         
Sbjct: 260  KGKFVGAFCSSNLGDV-SPNIMGPKCSISGNECDLLTSRCPAGEGECFASGPGRDMVEST 318

Query: 1546 ---GRRLAGSNITRRIRSSQENNAKFVS 1620
               G+RLA + +      SQE+ A+ V+
Sbjct: 319  QILGQRLADAALGLLNEQSQESTAREVT 346

>Q9I596:NCASE_PSEAE Neutral ceramidase precursor - Pseudomonas aeruginosa|
          Length = 670

 Score =  242 bits (617), Expect = 8e-63
 Identities = 197/621 (31%), Positives = 283/621 (45%), Gaps = 34/621 (5%)
 Frame = +1

Query: 1168 SAYLNNPAEERSKYKYNVDKEMTLVKFVDDESGPVGSFNWFATHGTSM-----SRTNSLI 1332
            + +L   A  ++KY    D+   ++      SGP G F+ +A +  S+        N+++
Sbjct: 93   AVHLKVLARLKAKYPGVYDENNVMLAATHTHSGP-GGFSHYAMYNLSVLGFQEKTFNAIV 151

Query: 1333 SGDNKGAAARFMEDWAEQNGLPKQTGVASSDDLGSLHMTSVLPRRVSTIIPEPDEITDDL 1512
             G       R +E  A+    P +    S +   +    S+L    +  I   ++  D  
Sbjct: 152  DG-----IVRSIER-AQARLQPGRLFYGSGELRNANRNRSLLSHLKNPDIVGYEDGIDPQ 205

Query: 1513 MQLASSYEASGGRRLAGSNITRRIRSSQENNAK------------------------FVS 1620
            M + S  +A+G   LAG+     + S+   NA                         FV+
Sbjct: 206  MSVLSFVDANG--ELAGAISWFPVHSTSMTNANHLISPDNKGYASYHWEHDVSRKSGFVA 263

Query: 1621 AFCQSNCGDVSPNVLGTFCIDTHLPCDFNHSTCNGKNELCYGRGPGYPNEFESTRIIGNR 1800
            AF Q+N G++SPN+                        L  G GP + NEF++TR IG R
Sbjct: 264  AFAQTNAGNLSPNL-----------------------NLKPGSGP-FDNEFDNTREIGLR 299

Query: 1801 QFLKAVDLFNSASEEIQGKIDYRHTYLDFSQLKVSVSTSTGGPQVVKTCXXXXXXXXXXX 1980
            QF KA ++   A EE+ G++D R  ++DF++L +    + G P+ + T            
Sbjct: 300  QFAKAYEIAGQAQEEVLGELDSRFRFVDFTRLPIRPEFTDGQPRQLCTAAIGTSLAAGST 359

Query: 1981 XXXXXXXXXFKQGDDKGNPFWRLVRNLLK-TPGKEQVECQAPKPILLDTGEMKEPYDWAP 2157
                         ++  NPF   +  LL   P +E V+CQA K IL DTG  K+PY W P
Sbjct: 360  EDGPGPLGL----EEGNNPFLSALGGLLTGVPPQELVQCQAEKTILADTGN-KKPYPWTP 414

Query: 2158 AILPIQIIRIGQLVILCVPGEFTTMAGRRLRDAVKNVLISGSNSEFGTNIHVVLAGLTNT 2337
             +LPIQ+ RIGQL +L  P EFT MAG R+R AV+      + SE     HVV  G  N 
Sbjct: 415  TVLPIQMFRIGQLELLGAPAEFTVMAGVRIRRAVQ------AASEAAGIRHVVFNGYANA 468

Query: 2338 YSQYVTTFEEYQIQRYEGASTLYGPHTLSAYIQEFQKLATAMIENKEVPTNIQPPDMLEK 2517
            Y+ YVTT EEY  Q YEG STLYGP T +AY Q F  +A A+ E   V T+   PD+   
Sbjct: 469  YASYVTTREEYAAQEYEGGSTLYGPWTQAAYQQLFVDMAVALRERLPVETSAIAPDLSCC 528

Query: 2518 QIGLLPGVMYDSTPRGVHFGDVSSDVAANSNFRKGSTVNATFYSACPRNDLLTEGTFALV 2697
            Q+    GV+ D    G  FGDV        ++R G  V   F +  P+NDL TE TF  V
Sbjct: 529  QMNFQTGVVADDPYIGKSFGDVLQQ--PRESYRIGDKVTVAFVTGHPKNDLRTEKTFLEV 586

Query: 2698 EKLNGNNW---IPVYDDDDWSLQFKWSRPSKFSPRSFATLEWTIPEDAASGVYRLRHSGA 2868
              +  +       V  D+DW  Q++W R       S AT+ W+IP     G Y +RH G 
Sbjct: 587  VNIGKDGKQTPETVATDNDWDTQYRWERVG--ISASKATISWSIPPGTEPGHYYIRHYGN 644

Query: 2869 SKPL-IGSIKHFTGTSRAFAV 2928
            +K      I    G++R+F V
Sbjct: 645  AKNFWTQKISEIGGSTRSFEV 665



 Score =  204 bits (519), Expect = 2e-51
 Identities = 117/289 (40%), Positives = 171/289 (59%), Gaps = 3/289 (1%)
 Frame = +1

Query: 688  DSPYLVGMGSYDITGPAADVNMMGYANTEQIASGIHFRLKSRAFIVAEP-NGERVVFVNL 864
            D PY  G+G  DITG AA+V MMGY++ EQ  +GIH R  +RAF++ E  +G R+V+VN 
Sbjct: 26   DLPYRFGLGKADITGEAAEVGMMGYSSLEQKTAGIHMRQWARAFVIEEAASGRRLVYVNT 85

Query: 865  DACMASQLVNIKVLERLKARYGDLYNENNVAISGIHTHAGPGGYLQYVVYIVTSLGFVRQ 1044
            D  M  Q V++KVL RLKA+Y  +Y+ENNV ++  HTH+GPGG+  Y +Y ++ LGF  +
Sbjct: 86   DLGMIFQAVHLKVLARLKAKYPGVYDENNVMLAATHTHSGPGGFSHYAMYNLSVLGFQEK 145

Query: 1045 SFDVIVDGIEQSIVEAHNNLHPGKIYVNKGDLIDAGVNRSPSAYLNNPAEERSKYKYNVD 1224
            +F+ IVDGI +SI  A   L PG+++   G+L +A  NRS  ++L NP  +   Y+  +D
Sbjct: 146  TFNAIVDGIVRSIERAQARLQPGRLFYGSGELRNANRNRSLLSHLKNP--DIVGYEDGID 203

Query: 1225 KEMTLVKFVDDESGPVGSFNWFATHGTSMSRTNSLISGDNKGAAARFME-DWAEQNGLPK 1401
             +M+++ FVD      G+ +WF  H TSM+  N LIS DNKG A+   E D + ++G   
Sbjct: 204  PQMSVLSFVDANGELAGAISWFPVHSTSMTNANHLISPDNKGYASYHWEHDVSRKSGF-- 261

Query: 1402 QTGVASSDDLGSLHMTSVLPRRVSTIIPEPDEITD-DLMQLASSYEASG 1545
                 +  + G+L     L         E D   +  L Q A +YE +G
Sbjct: 262  -VAAFAQTNAGNLSPNLNLKPGSGPFDNEFDNTREIGLRQFAKAYEIAG 309

>P80109:PHLD_BOVIN Phosphatidylinositol-glycan-specific phospholipase D precursor - Bos|
            taurus (Bovine)
          Length = 839

 Score = 33.5 bits (75), Expect = 5.6
 Identities = 22/66 (33%), Positives = 31/66 (46%), Gaps = 3/66 (4%)
 Frame = +1

Query: 973  THAGPGGYLQYVVYIVTSLGFVRQSFDVIVDGIEQSIVEAHNNLHPGKIYVNKGDLI--- 1143
            TH        Y+ +  T LG+   S D+  DG    +V A    HPG+I+V +  LI   
Sbjct: 362  THVSSPAASYYLSFPYTRLGWAMTSADLNQDGYGDLVVGAPGYSHPGRIHVGRVYLIYGN 421

Query: 1144 DAGVNR 1161
            D G+ R
Sbjct: 422  DLGLPR 427


  Database: uniprot_sprot.fasta.out
    Posted date:  Jul 19, 2007  5:58 PM
  Number of letters in database: 100,686,439
  Number of sequences in database:  274,295
  
Lambda     K      H
   0.318    0.134    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 274295
Number of Hits to DB: 573,931,184
Number of extensions: 13205165
Number of successful extensions: 36103
Number of sequences better than 10.0: 11
Number of HSP's gapped: 35959
Number of HSP's successfully gapped: 20
Length of query: 1043
Length of database: 100,686,439
Length adjustment: 124
Effective length of query: 919
Effective length of database: 66,673,859
Effective search space: 61273276421
Effective search space used: 61273276421
Neighboring words threshold: 12
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)