ナショナルバイオリソースプロジェクト
-Barley Genetic Resources Database-
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| Clone Name | FLbaf44d22 |
|---|---|
| Clone Library Name | barley_pub |
>Q2M2I8:AAK1_HUMAN AP2-associated protein kinase 1 - Homo sapiens (Human)| Length = 863 Score = 216 bits (549), Expect = 6e-55 Identities = 133/340 (39%), Positives = 189/340 (55%), Gaps = 5/340 (1%) Frame = +3 Query: 711 SGPSGGLEGRTIDVGNVKVHVREAIAEGGFSCVYLARDLTNPAKHYALKHVIVQDKESLD 890 SG G GR +G +V V E +AEGGF+ V+L R T+ ALK + V ++ L Sbjct: 28 SGLGSGYIGRVFGIGRQQVTVDEVLAEGGFAIVFLVR--TSNGMKCALKRMFVNNEHDLQ 85 Query: 891 LVHKEITVMRALKGHPNVVTLVAHTILDMGRGR--EALLLMEFCERS-LVSALDARGTAG 1061 + +EI +MR L GH N+V + +I ++ G E L+LM+FC +V+ ++ R G Sbjct: 86 VCKREIQIMRDLSGHKNIVGYIDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTG 145 Query: 1062 FYDDEQVALIFRDICNAVFAMHCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKC 1241 F ++E V IF D C AV +H P+ HRDLK EN+LL G + LCDFGS + Sbjct: 146 FTENE-VLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNK--- 201 Query: 1242 FDKPEERGIE--EDIIRKHTTPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSA 1415 F P+ G+ ED I+K+TT +YRAPEM +LY ++I+ K DIWALGCL+Y++CY Sbjct: 202 FQNPQTEGVNAVEDEIKKYTTLSYRAPEMVNLYSGKIITTKADIWALGCLLYKLCYFTLP 261 Query: 1416 FDGESKLQILNGNYRIPELPKYCSSITSLIEEMLQSSPDARPDITQVWFRVNELLPLELQ 1595 F GES++ I +GN+ IP+ +Y + LI ML+ PD RPDI QV + +LL E Sbjct: 262 F-GESQVAICDGNFTIPDNSRYSQDMHCLIRYMLEPDPDKRPDIYQVSYFSFKLLKKECP 320 Query: 1596 KDLPDGSPSGSAFELQITEHEGLASSILPV*RIEATADPL 1715 SP + + E A P R+ DP+ Sbjct: 321 IPNVQNSPIPAKLPEPVKASEAAAKKTQPKARL---TDPI 357
>Q3UHJ0:AAK1_MOUSE AP2-associated protein kinase 1 - Mus musculus (Mouse)| Length = 959 Score = 212 bits (540), Expect = 7e-54 Identities = 131/340 (38%), Positives = 188/340 (55%), Gaps = 5/340 (1%) Frame = +3 Query: 711 SGPSGGLEGRTIDVGNVKVHVREAIAEGGFSCVYLARDLTNPAKHYALKHVIVQDKESLD 890 SG G GR +G +V V E +AEGGF+ V+L R T+ ALK + V ++ L Sbjct: 28 SGLGSGYIGRVFGIGRQQVTVDEVLAEGGFALVFLVR--TSNGVKCALKRMFVNNEHDLQ 85 Query: 891 LVHKEITVMRALKGHPNVVTLVAHTILDMGRGR--EALLLMEFCERS-LVSALDARGTAG 1061 + +EI +MR L GH N+V + +I ++ G E L+LM+FC +V+ ++ R G Sbjct: 86 VCKREIQIMRDLSGHKNIVGYIDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTG 145 Query: 1062 FYDDEQVALIFRDICNAVFAMHCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKC 1241 F ++E V IF D C AV +H P+ HRDLK EN+LL G + LCDFGS + Sbjct: 146 FTENE-VLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNK--- 201 Query: 1242 FDKPEERGIE--EDIIRKHTTPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSA 1415 F P+ G+ ED I+K+TT +YRAPEM +LY ++I+ K DIWALGCL+Y++CY Sbjct: 202 FQNPQAEGVNAVEDEIKKYTTLSYRAPEMVNLYSGKIITTKADIWALGCLLYKLCYFTLP 261 Query: 1416 FDGESKLQILNGNYRIPELPKYCSSITSLIEEMLQSSPDARPDITQVWFRVNELLPLELQ 1595 F GES++ I +G++ IP+ +Y + LI ML+ PD RPDI QV + +LL E Sbjct: 262 F-GESQVAICDGSFTIPDNSRYSQDMHCLIRYMLEPDPDKRPDIYQVSYFSFKLLKKECP 320 Query: 1596 KDLPDGSPSGSAFELQITEHEGLASSILPV*RIEATADPL 1715 SP + + E P R+ DP+ Sbjct: 321 VPNVQNSPIPAKLPEPVKASEAAVKKTQPKARL---TDPI 357
>P0C1X8:AAK1_RAT AP2-associated protein kinase 1 - Rattus norvegicus (Rat)| Length = 962 Score = 207 bits (528), Expect = 2e-52 Identities = 131/340 (38%), Positives = 188/340 (55%), Gaps = 5/340 (1%) Frame = +3 Query: 711 SGPSGGLEGRTIDVGNVKVHVREAIAEGGFSCVYLARDLTNPAKHYALKHVIVQDKESLD 890 SG G GR +G +V V E +AEGGF+ V+L R T+ ALK + V ++ L Sbjct: 28 SGLGSGYIGRVFGIGRQQVTVDEVLAEGGFALVFLVR--TSNGVKCALKRMFVNNEHDLQ 85 Query: 891 LVHKEITVMRALKGHPNVVTLVAHTILDMGRGR--EALLLMEFCERS-LVSALDARGTAG 1061 + +EI +MR L GH N+V + +I ++ G E L+LM+FC +V+ ++ R G Sbjct: 86 VCKREIQIMRDLSGHKNIVGYIDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTG 145 Query: 1062 FYDDEQVALIFRDICNAVFAMHCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKC 1241 F ++E V IF D C AV +H P+ HRDLK EN+LL G + LCDFGS + Sbjct: 146 FTENE-VLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNK--- 201 Query: 1242 FDKPEERGIE--EDIIRKHTTPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSA 1415 F P+ G+ ED I+K+TT +YRAPEM +LY ++I+ K DIWALGCL+Y++CY Sbjct: 202 FQNPQAEGVNAVEDEIKKYTTLSYRAPEMVNLYSGKIITTKADIWALGCLLYKLCYFTLP 261 Query: 1416 FDGESKLQILNGNYRIPELPKYCSSITSLIEEMLQSSPDARPDITQVWFRVNELLPLELQ 1595 F GES++ I +G++ IP+ +Y + LI ML+ PD RPDI QV + +LL E Sbjct: 262 F-GESQVAICDGSFTIPDNSRYSQDMHCLI-YMLEPDPDKRPDIYQVSYFSFKLLKKECP 319 Query: 1596 KDLPDGSPSGSAFELQITEHEGLASSILPV*RIEATADPL 1715 SP + + E P R+ DP+ Sbjct: 320 VPNVQNSPIPTKLPEPVKASEAAVKKTQPKARL---TDPI 356
>O14976:GAK_HUMAN Cyclin G-associated kinase - Homo sapiens (Human)| Length = 1311 Score = 202 bits (514), Expect = 7e-51 Identities = 114/289 (39%), Positives = 167/289 (57%), Gaps = 8/289 (2%) Frame = +3 Query: 735 GRTIDVGNVKVHVREAIAEGGFSCVYLARDLTNPAKHYALKHVIVQDKESLDLVHKEITV 914 G+T+++G +++ VR +AEGGF+ VY A+D+ + + YALK ++ ++E + +E+ Sbjct: 30 GQTVELGELRLRVRRVLAEGGFAFVYEAQDVGS-GREYALKRLLSNEEEKNRAIIQEVCF 88 Query: 915 MRALKGHPNVVTLVAHTIL-----DMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQ 1079 M+ L GHPN+V + + D G+ E LLL E C+ LV L + G + Sbjct: 89 MKKLSGHPNIVQFCSAASIGKEESDTGQA-EFLLLTELCKGQLVEFLKKMESRGPLSCDT 147 Query: 1080 VALIFRDICNAVFAMHCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFD---K 1250 V IF C AV MH Q PP+ HRDLK EN+LL G KLCDFGS +T D Sbjct: 148 VLKIFYQTCRAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTISHYPDYSWS 207 Query: 1251 PEERGIEEDIIRKHTTPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGES 1430 + R + E+ I ++TTP YR PE+ DLY I EK DIWALGC++Y +C+ + F+ + Sbjct: 208 AQRRALVEEEITRNTTPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFRQHPFEDGA 267 Query: 1431 KLQILNGNYRIPELPKYCSSITSLIEEMLQSSPDARPDITQVWFRVNEL 1577 KL+I+NG Y IP + SLI MLQ +P+ R I +V ++ E+ Sbjct: 268 KLRIVNGKYSIPPHDTQYTVFHSLIRAMLQVNPEERLSIAEVVHQLQEI 316
>Q9NSY1:BMP2K_HUMAN BMP-2-inducible protein kinase - Homo sapiens (Human)| Length = 1161 Score = 196 bits (498), Expect = 5e-49 Identities = 121/312 (38%), Positives = 174/312 (55%), Gaps = 25/312 (8%) Frame = +3 Query: 696 MPKEHSGPSGGLEG---------------------RTIDVGNVKVHVREAIAEGGFSCVY 812 MPK G GG G R VG +V + E++AEGGFS V+ Sbjct: 7 MPKSEGGSGGGAAGGGAGGAGAGAGCGSGGSSVGVRVFAVGRHQVTLEESLAEGGFSTVF 66 Query: 813 LARDLTNPAKHYALKHVIVQDKESLDLVHKEITVMRALKGHPNVVTLVAHTILDMGRGR- 989 L R T+ ALK + V + L++ +EIT+M+ L GH N+V + + + Sbjct: 67 LVR--THGGIRCALKRMYVNNMPDLNVCKREITIMKELSGHKNIVGYLDCAVNSISDNVW 124 Query: 990 EALLLMEFCERS-LVSALDARGTAGFYDDEQVALIFRDICNAVFAMHCQTPPVAHRDLKA 1166 E L+LME+C +V+ ++ + GF + E V IF D C AV +H P+ HRDLK Sbjct: 125 EVLILMEYCRAGQVVNQMNKKLQTGFTEPE-VLQIFCDTCEAVARLHQCKTPIIHRDLKV 183 Query: 1167 ENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIE--EDIIRKHTTPAYRAPEMWDLYRR 1340 EN+LL G + LCDFGS + F P++ G+ E+ I+K+TT +YRAPEM +LY Sbjct: 184 ENILLNDGGNYVLCDFGSATNK---FLNPQKDGVNVVEEEIKKYTTLSYRAPEMINLYGG 240 Query: 1341 EVISEKVDIWALGCLMYRICYLKSAFDGESKLQILNGNYRIPELPKYCSSITSLIEEMLQ 1520 + I+ K DIWALGCL+Y++C+ F GES++ I +GN+ IP+ +Y +I LI ML+ Sbjct: 241 KPITTKADIWALGCLLYKLCFFTLPF-GESQVAICDGNFTIPDNSRYSRNIHCLIRFMLE 299 Query: 1521 SSPDARPDITQV 1556 P+ RPDI QV Sbjct: 300 PDPEHRPDIFQV 311
>P97874:GAK_RAT Cyclin G-associated kinase - Rattus norvegicus (Rat)| Length = 1305 Score = 195 bits (496), Expect = 8e-49 Identities = 111/289 (38%), Positives = 166/289 (57%), Gaps = 8/289 (2%) Frame = +3 Query: 735 GRTIDVGNVKVHVREAIAEGGFSCVYLARDLTNPAKHYALKHVIVQDKESLDLVHKEITV 914 G+T+++G +++ VR +AEGGF+ VY A+DL + + YALK ++ ++E + +E+ Sbjct: 30 GQTVELGELRLRVRRVLAEGGFAFVYEAQDLGS-GREYALKRLLSNEEEKNRAIIQEVCF 88 Query: 915 MRALKGHPNVVTLVAHTIL-----DMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQ 1079 ++ L GHPN+V + + D G+ E LLL E C+ LV L G + Sbjct: 89 LKKLSGHPNIVQFCSAASIGKEESDTGQA-EFLLLTELCKGQLVEFLRRVECKGPLSCDS 147 Query: 1080 VALIFRDICNAVFAMHCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFD---K 1250 + IF C AV MH Q PP+ HRDLK EN+LL G KLCDFGS +T D Sbjct: 148 ILKIFYQTCRAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTISHYPDYSWS 207 Query: 1251 PEERGIEEDIIRKHTTPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGES 1430 ++R + E+ I ++TTP YR PE+ DLY I EK DIWALGC++Y +C+ + F+ + Sbjct: 208 AQKRAMVEEEITRNTTPMYRTPEIVDLYSNFPIGEKQDIWALGCILYLLCFRQHPFEDGA 267 Query: 1431 KLQILNGNYRIPELPKYCSSITSLIEEMLQSSPDARPDITQVWFRVNEL 1577 KL+I+NG Y IP + LI ML+ +P+ R I +V ++ E+ Sbjct: 268 KLRIVNGKYSIPVNDTRYTVFHDLIRGMLKVNPEERLSIAEVVRQLQEI 316
>Q99KY4:GAK_MOUSE Cyclin G-associated kinase - Mus musculus (Mouse)| Length = 1305 Score = 194 bits (493), Expect = 2e-48 Identities = 111/289 (38%), Positives = 165/289 (57%), Gaps = 8/289 (2%) Frame = +3 Query: 735 GRTIDVGNVKVHVREAIAEGGFSCVYLARDLTNPAKHYALKHVIVQDKESLDLVHKEITV 914 G+T+++G +++ VR +AEGGF+ VY A+DL + + YALK ++ ++E + +E+ Sbjct: 30 GQTVELGELRLRVRRVLAEGGFAFVYEAQDLGS-GREYALKRLLSNEEEKNRAIIQEVCF 88 Query: 915 MRALKGHPNVVTLVAHTIL-----DMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQ 1079 ++ L GHPN+V + + D G+ E LLL E C+ LV L G + Sbjct: 89 LKKLSGHPNIVQFCSAASIGKEESDTGQA-EFLLLTELCKGQLVEFLKRVECKGPLSCDS 147 Query: 1080 VALIFRDICNAVFAMHCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFD---K 1250 + IF C AV MH Q PP+ HRDLK EN+LL G KLCDFGS +T D Sbjct: 148 ILKIFYQTCRAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTISHYPDYSWS 207 Query: 1251 PEERGIEEDIIRKHTTPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGES 1430 ++R + E+ I ++TTP YR PE+ DLY I EK DIWALGC++Y +C+ + F+ + Sbjct: 208 AQKRAMVEEEITRNTTPMYRTPEIVDLYSNFPIGEKQDIWALGCILYLLCFRQHPFEDGA 267 Query: 1431 KLQILNGNYRIPELPKYCSSITSLIEEMLQSSPDARPDITQVWFRVNEL 1577 KL+I+NG Y IP + LI ML+ +P R I +V ++ E+ Sbjct: 268 KLRIVNGKYSIPVNDTRYTVFHDLIRAMLKVNPVERLSIAEVVRQLQEI 316
>Q91Z96:BMP2K_MOUSE BMP-2-inducible protein kinase - Mus musculus (Mouse)| Length = 1138 Score = 194 bits (493), Expect = 2e-48 Identities = 113/283 (39%), Positives = 169/283 (59%), Gaps = 4/283 (1%) Frame = +3 Query: 720 SGGLEGRTIDVGNVKVHVREAIAEGGFSCVYLARDLTNPAKHYALKHVIVQDKESLDLVH 899 S + R VG +V + E++AEGGFS V+L R T+ ALK + V + L++ Sbjct: 33 SSSMGVRVFAVGRYQVTLEESLAEGGFSTVFLVR--THSGIRCALKRMYVNNTPDLNICK 90 Query: 900 KEITVMRALKGHPNVVTLVAHTILDMGRGR-EALLLMEFCERS-LVSALDARGTAGFYDD 1073 +EIT+M+ L GH N+V + + + E L+LME+C +V+ ++ + GF + Sbjct: 91 REITIMKELSGHKNIVGYLDCAVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTGFTES 150 Query: 1074 EQVALIFRDICNAVFAMHCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKP 1253 E V IF D C AV +H P+ HRDLK EN+LL G + LCDFGS + F P Sbjct: 151 E-VLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLNDAGNYVLCDFGSATNK---FLNP 206 Query: 1254 EERGIE--EDIIRKHTTPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGE 1427 ++ G+ E+ I+K+TT +YRAPEM +LY + I+ K DIWALGCL+Y++C+ F GE Sbjct: 207 QKDGVNVVEEEIKKYTTLSYRAPEMINLYGGKPITTKADIWALGCLLYKLCFFTLPF-GE 265 Query: 1428 SKLQILNGNYRIPELPKYCSSITSLIEEMLQSSPDARPDITQV 1556 S++ I +G++ IP+ +Y ++ LI ML+ P+ RPDI QV Sbjct: 266 SQVAICDGSFTIPDNSRYSHNVHCLIRFMLEPDPECRPDIFQV 308
>O43066:PPK30_SCHPO Serine/threonine-protein kinase ppk30 - Schizosaccharomyces pombe| (Fission yeast) Length = 953 Score = 192 bits (487), Expect = 9e-48 Identities = 119/295 (40%), Positives = 159/295 (53%), Gaps = 3/295 (1%) Frame = +3 Query: 735 GRTIDVGNVKVHVREAIAEGGFSCVYLARDLTNPAKHYALKHVIVQDKESLDLVHKEITV 914 G I VG+ V ++ ++EGGFS VYLA L K + LK + V DK +L LVH EI Sbjct: 47 GTKIQVGSHSVIIQRYLSEGGFSHVYLA--LLENEKPFVLKRIYVPDKTALQLVHGEIET 104 Query: 915 MRALKGHPNVVTLVAHTIL-DMGRGR-EALLLMEFCERS-LVSALDARGTAGFYDDEQVA 1085 M+ LKGH ++V + + L R E LLMEFC L+ ++ R + E + Sbjct: 105 MKRLKGHRHIVNYIDSSALYSKSENRYEVYLLMEFCAGGGLIDFMNTRLQHRLTEGE-IL 163 Query: 1086 LIFRDICNAVFAMHCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERG 1265 I D+C+AV AMH PP+ HRDLK ENVLL A ++KLCDFGS P+ Sbjct: 164 KILADVCDAVAAMHYLDPPLIHRDLKIENVLLVAPNSYKLCDFGSACEPLAPATTPDTIM 223 Query: 1266 IEEDIIRKHTTPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQIL 1445 E I +TTP YRAPEM D+ RR+ I EK DIWA+G L Y++CY + F+ IL Sbjct: 224 FLEQNIAAYTTPQYRAPEMIDINRRQGIDEKSDIWAIGVLAYKLCYYTTPFEQVGNSAIL 283 Query: 1446 NGNYRIPELPKYCSSITSLIEEMLQSSPDARPDITQVWFRVNELLPLELQKDLPD 1610 ++ P P+Y + I LQ P RP+I Q + E+ L+ LPD Sbjct: 284 KASFSFPPFPRYSDRMKRFIATCLQEQPSHRPNIYQTLKEIMEMQGTPLK--LPD 336
>P40494:PRK1_YEAST Actin-regulating kinase PRK1 - Saccharomyces cerevisiae (Baker's| yeast) Length = 810 Score = 172 bits (436), Expect = 8e-42 Identities = 104/288 (36%), Positives = 157/288 (54%), Gaps = 7/288 (2%) Frame = +3 Query: 735 GRTIDVGNVKVHVREAIAEGGFSCVYLAR----DLTNPAKHYALKHVIVQDKESLDLVHK 902 G + VG+ + + + GGF+ VY A D + A LK VIV K+ L+ + Sbjct: 12 GTILTVGSHHAKIIKYLTSGGFAQVYTAEISPPDPYSNANIACLKRVIVPHKQGLNTLRA 71 Query: 903 EITVMRALKGHPNVVTLV-AHTILDM-GRGREALLLMEFCERS-LVSALDARGTAGFYDD 1073 E+ M+ L+ + +VV+ + +H + G E +LMEFCER L+ ++ R + Sbjct: 72 EVDAMKLLRNNKHVVSYIDSHAARSVNGIAYEVFVLMEFCERGGLIDFMNTRLQNRLQES 131 Query: 1074 EQVALIFRDICNAVFAMHCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKP 1253 E + ++ + + + AMH PP+ HRD+K ENVL+ DG +K+CDFGSVS + Sbjct: 132 EILEIMSQTV-QGITAMHALQPPLIHRDIKIENVLISHDGLYKVCDFGSVSGVIRPPRNT 190 Query: 1254 EERGIEEDIIRKHTTPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESK 1433 +E + I +TT YR+PEM DLYR I EK DIWALG +Y+ICY + F+ + Sbjct: 191 QEFNYVQHDILTNTTAQYRSPEMIDLYRGLPIDEKSDIWALGVFLYKICYYTTPFEKSGE 250 Query: 1434 LQILNGNYRIPELPKYCSSITSLIEEMLQSSPDARPDITQVWFRVNEL 1577 IL+ Y+ P P+Y + +LI ML +P RP+I QV V+ L Sbjct: 251 AGILHARYQYPSFPQYSDRLKNLIRLMLMEAPSQRPNICQVLEEVSRL 298
>P53974:ARK1_YEAST Actin-regulating kinase 1 - Saccharomyces cerevisiae (Baker's yeast)| Length = 638 Score = 171 bits (432), Expect = 2e-41 Identities = 106/290 (36%), Positives = 157/290 (54%), Gaps = 11/290 (3%) Frame = +3 Query: 735 GRTIDVGNVKVHVREAIAEGGFSCVYLARDLTNPAKHYA------LKHVIVQDKESLDLV 896 G + VG+ +V + + + GGF+ VY A L NP ++ LK VIV DK SL+ + Sbjct: 12 GTQLTVGSHQVEIIKYLTSGGFAQVYSA--LINPPDPHSNSSVACLKRVIVPDKPSLNTL 69 Query: 897 HKEITVMRALKGHPNVVTLV----AHTILDMGRGREALLLMEFCERS-LVSALDARGTAG 1061 E+ MR LK + VV+ + A +L G E +LME+CER L+ ++ R Sbjct: 70 RAEVDAMRLLKNNRYVVSYIDSHAAKAMLHNG-SYEVFVLMEYCERGGLIDFMNTRLQNR 128 Query: 1062 FYDDEQVALIFRDICNAVFAMHCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKC 1241 ++ E + I + V AMH PP+ HRD+K ENVL+ A+ +KLCDFGSV + Sbjct: 129 LHEFE-ILQIMSQVTQGVAAMHALQPPLIHRDIKIENVLISANNEYKLCDFGSVCGIIRP 187 Query: 1242 FDKPEERGIEEDIIRKHTTPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFD 1421 +E + I K+TT YR+PEM D +R I EK DIWALG +Y++CY + F+ Sbjct: 188 PRNSQELSYVQQDILKNTTAQYRSPEMIDTFRGLPIDEKSDIWALGIFLYKLCYYTTPFE 247 Query: 1422 GESKLQILNGNYRIPELPKYCSSITSLIEEMLQSSPDARPDITQVWFRVN 1571 L IL+G + P P Y + LI ++L P RP++ Q+ R++ Sbjct: 248 KGGDLAILSGKFEFPLYPNYSEQLKGLIRDILVQDPRHRPNVYQLLKRIS 297
>P38080:AKL1_YEAST Serine/threonine-protein kinase AKL1 - Saccharomyces cerevisiae| (Baker's yeast) Length = 1108 Score = 169 bits (427), Expect = 8e-41 Identities = 111/303 (36%), Positives = 166/303 (54%), Gaps = 17/303 (5%) Frame = +3 Query: 735 GRTIDVGNVKVHVREAIAEGGFSCVYLARDLT--NPAKHYA-----------LKHVIVQD 875 G + VG KV V +AEGGF+ +Y+ + L N + A LK V+VQD Sbjct: 25 GHIVCVGTHKVEVVNYLAEGGFAQIYVVKFLEYLNEFDNTASVPLKIGDVACLKRVLVQD 84 Query: 876 KESLDLVHKEITVMRALKGHPNVVTLV---AHTILDMGRGREALLLMEFC-ERSLVSALD 1043 + L+ + E+ VM+ LKG PN+V A D +G E LLLME C +SL+ ++ Sbjct: 85 ENGLNEMRNEVEVMKKLKGAPNIVQYFDSNASRRRDGVQGFEVLLLMELCPNKSLLDYMN 144 Query: 1044 ARGTAGFYDDEQVALIFRDICNAVFAMHCQTPPVAHRDLKAENVLLGADGAWKLCDFGSV 1223 R + + E V +++ D+ ++ MH + HRD+K ENVL+ A +KL DFGS Sbjct: 145 QRLSTKLTEAEIVKIMY-DVALSISQMHYLPVSLIHRDIKIENVLVDAKNNFKLADFGST 203 Query: 1224 STNHKCFDKPEERGIEEDIIRKHTTPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICY 1403 ST ++ + I HTTP YR+PEM DLYR I+EK DIWALG +Y++ + Sbjct: 204 STCFPIVTTHQDIALLTQNIYVHTTPQYRSPEMIDLYRCLPINEKSDIWALGVFLYKLLF 263 Query: 1404 LKSAFDGESKLQILNGNYRIPELPKYCSSITSLIEEMLQSSPDARPDITQVWFRVNELLP 1583 + F+ + IL+ Y P + KY S + +LI ML +P+ RP+I QV + + E+L Sbjct: 264 FTTPFEMTGQFAILHSKYEFP-VNKYSSKLINLIIIMLAENPNLRPNIYQVLYHLCEILN 322 Query: 1584 LEL 1592 +E+ Sbjct: 323 VEV 325
>Q9USS2:PPK29_SCHPO Serine/threonine-protein kinase ppk29 - Schizosaccharomyces pombe| (Fission yeast) Length = 872 Score = 162 bits (410), Expect = 8e-39 Identities = 109/294 (37%), Positives = 152/294 (51%), Gaps = 11/294 (3%) Frame = +3 Query: 729 LEGRTIDVGNVKVHVREAIAEGGFSCVYLARDLTNPAKHYA-----LKHVIVQDKESLDL 893 L G +G V + + IAEGGFS VYL + TN + LK + D+ +L Sbjct: 13 LAGSKFVIGKYNVTIEKYIAEGGFSHVYLVQ--TNSKTDGSPITAVLKRMYSPDENALRF 70 Query: 894 VHKEITVMRALKGHPNVVTLVAHTILDMGR-----GREALLLMEFCERS-LVSALDARGT 1055 V EI M LK +P+VV+ + I + + G E LLLME+C L+ ++ R Sbjct: 71 VKTEIETMELLKSNPHVVSYIDSCIFPLEKAGVNTGFEILLLMEYCAGGGLIDFMNQRLQ 130 Query: 1056 AGFYDDEQVALIFRDICNAVFAMHCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNH 1235 + E V I DI V ++H PP+ HRDLK ENVLL + +KLCDFGSV+ Sbjct: 131 TRLSEHE-VLKIISDIVQGVASLHYLRPPLIHRDLKVENVLLSFN-TFKLCDFGSVTEPM 188 Query: 1236 KCFDKPEERGIEEDIIRKHTTPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSA 1415 + E E I TT YRAPEM +LY I EK D+WALG L+Y++CY + Sbjct: 189 HAAENSSEIQALEKSINTFTTYQYRAPEMINLYSGLGIDEKSDMWALGVLLYKLCYYTTP 248 Query: 1416 FDGESKLQILNGNYRIPELPKYCSSITSLIEEMLQSSPDARPDITQVWFRVNEL 1577 F+ + IL +Y P P Y S+ ++I +LQ +P RP+I Q+ + L Sbjct: 249 FETQGPNAILTASYSFPPFPPYSHSLKNVIIALLQPNPCLRPNIFQLMCEICRL 302
>Q9UU85:PPK38_SCHPO Protein kinase domain-containing protein ppk38 - Schizosaccharomyces| pombe (Fission yeast) Length = 650 Score = 160 bits (406), Expect = 2e-38 Identities = 112/325 (34%), Positives = 165/325 (50%), Gaps = 19/325 (5%) Frame = +3 Query: 717 PSGGLE-GRTIDVGNVKVHVREAIAEGGFSCVYLARDLTNPAK---HYALKHVIVQDKES 884 PSG L G + V V V+ +AEGGFS VYL + L P K LK + D + Sbjct: 16 PSGLLPVGFSCTVEKFSVTVKRYLAEGGFSHVYLVQ-LVFPGKPPFEAVLKRIFATDAMA 74 Query: 885 LDLVHKEITVMRALKGHPNVVTLVAHTILDMGRGR-EALLLMEFCE-RSLVSALDARGTA 1058 L VH+E+ M+ + V+ + + E L+L+E+C L+ L+ R Sbjct: 75 LRAVHEEVRTMKLVSNQKRCVSYYGSEFFRTSKNQFEVLVLLEYCPCGGLIDFLNTRLQV 134 Query: 1059 GFYDDEQVALIFRDICNAVFAMHCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHK 1238 ++++ I D+ AV MH PP+ HRDLK ENVLL A ++KLCDFGS Sbjct: 135 RL-SEQEILKIASDVTEAVAVMHYLKPPLIHRDLKIENVLLAAPNSYKLCDFGSA----- 188 Query: 1239 CFDKP------EERGIEEDIIRKHTTPAYRAPEMWDLYRREVISEKVDIWALGCLMYRIC 1400 C P E + +E DI K TT YR PEM ++++ I EK DIWALG L Y++C Sbjct: 189 CHPIPGAKTAAEAKQLEYDI-EKFTTWQYRCPEMINVHKGFGIDEKSDIWALGVLFYKLC 247 Query: 1401 YLKSAFDGESKLQILNGNYRIPELPKYCSSITSLIEEMLQSSPDARPDITQVWFRVNEL- 1577 Y + F+ + I+N +Y P P Y + LI +LQ P RP+I Q + + ++ Sbjct: 248 YYTTPFEHQGLAAIMNVSYAFPTFPPYSDRLKRLISTLLQQYPWQRPNIYQTFCEICKMR 307 Query: 1578 -LPLELQ-----KDLPDGSPSGSAF 1634 +P+ + K++ +PSGS + Sbjct: 308 NVPIHIYDIYNGKNVSSCNPSGSEY 332
>O75716:STK16_HUMAN Serine/threonine-protein kinase 16 - Homo sapiens (Human)| Length = 305 Score = 130 bits (328), Expect = 3e-29 Identities = 87/292 (29%), Positives = 147/292 (50%), Gaps = 11/292 (3%) Frame = +3 Query: 741 TIDVGNVKVHVREAIAEGGFSCVYLARDLTNPAKHYALKHVIVQDKESLDLVHKEITVMR 920 T+ + N + + + EGGFS V L L + YALK ++ +++ + +E + R Sbjct: 12 TVIIDNKRYLFIQKLGEGGFSYVDLVEGL-HDGHFYALKRILCHEQQDREEAQREADMHR 70 Query: 921 ALKGHPNVVTLVAHTILDMGRGREALLLMEFCERSL----VSALDARGTAGFYDDEQVAL 1088 L HPN++ LVA+ + + G EA LL+ F +R + L +G F ++Q+ Sbjct: 71 -LFNHPNILRLVAYCLRERGAKHEAWLLLPFFKRGTLWNEIERLKDKGN--FLTEDQILW 127 Query: 1089 IFRDICNAVFAMHCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGI 1268 + IC + A+H + AHRDLK N+LLG +G L D GS+ N C R Sbjct: 128 LLLGICRGLEAIHAKG--YAHRDLKPTNILLGDEGQPVLMDLGSM--NQACIHVEGSRQA 183 Query: 1269 E--EDIIRKHTTPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFD-----GE 1427 +D + T +YRAPE++ + VI E+ D+W+LGC++Y + + + +D G+ Sbjct: 184 LTLQDWAAQRCTISYRAPELFSVQSHCVIDERTDVWSLGCVLYAMMFGEGPYDMVFQKGD 243 Query: 1428 SKLQILNGNYRIPELPKYCSSITSLIEEMLQSSPDARPDITQVWFRVNELLP 1583 S + IP+ P++ S++ L+ M+ P RP I + ++ L P Sbjct: 244 SVALAVQNQLSIPQSPRHSSALRQLLNSMMTVDPHQRPHIPLLLSQLEALQP 295
>P57760:STK16_RAT Serine/threonine-protein kinase 16 - Rattus norvegicus (Rat)| Length = 305 Score = 130 bits (326), Expect = 4e-29 Identities = 85/292 (29%), Positives = 149/292 (51%), Gaps = 11/292 (3%) Frame = +3 Query: 741 TIDVGNVKVHVREAIAEGGFSCVYLARDLTNPAKHYALKHVIVQDKESLDLVHKEITVMR 920 T+ + N + + + EGGFS V L L + YALK ++ +++ + +E + R Sbjct: 12 TVIIDNKRYLFVQKLGEGGFSYVDLVEGL-HDGHFYALKRILCHEQQDQEEAQREADMHR 70 Query: 921 ALKGHPNVVTLVAHTILDMGRGREALLLMEFCERSL----VSALDARGTAGFYDDEQVAL 1088 + HPN++ L+A+++ + G EA LL+ F +R + L +G F ++Q+ Sbjct: 71 LFQ-HPNILRLMAYSLKERGAKHEAWLLLPFFKRGTLWNEIERLKDQGN--FLTEDQILP 127 Query: 1089 IFRDICNAVFAMHCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGI 1268 + IC + A+H + AHRDLK N+LLG +G L D GS+ N C R Sbjct: 128 LLLGICRGLEAIHAKG--YAHRDLKPTNILLGDEGQPVLMDLGSM--NQACIQVEGSRQA 183 Query: 1269 E--EDIIRKHTTPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFD-----GE 1427 +D + T +YRAPE++ + VI E+ D+W+LGC++Y + + + +D G+ Sbjct: 184 LALQDWAAQRCTISYRAPELFSVQSHCVIDERTDVWSLGCVLYAMMFGEGPYDMVFQKGD 243 Query: 1428 SKLQILNGNYRIPELPKYCSSITSLIEEMLQSSPDARPDITQVWFRVNELLP 1583 S + + IP+ P++ S++ L+ M+ P RP I + ++ L P Sbjct: 244 SVALAVQNDLSIPQSPRHSSALRQLLASMMTVDPQQRPHIPVLLSQLEALQP 295
>O88697:STK16_MOUSE Serine/threonine-protein kinase 16 - Mus musculus (Mouse)| Length = 305 Score = 125 bits (314), Expect = 1e-27 Identities = 83/292 (28%), Positives = 148/292 (50%), Gaps = 11/292 (3%) Frame = +3 Query: 741 TIDVGNVKVHVREAIAEGGFSCVYLARDLTNPAKHYALKHVIVQDKESLDLVHKEITVMR 920 T+ + N + + + EGGFS V L L + YALK ++ +++ + +E + R Sbjct: 12 TVIIDNKRYLFVQKLGEGGFSYVDLVEGL-HDGHFYALKRILCHEQQDQEEAQREAEMHR 70 Query: 921 ALKGHPNVVTLVAHTILDMGRGREALLLMEFCERSL----VSALDARGTAGFYDDEQVAL 1088 + HPN++ L+A+++ + G EA LL+ F ++ + L +G+ F ++Q+ Sbjct: 71 LFQ-HPNILRLMAYSLKERGAKHEAWLLLPFFKKGTLWNEIERLKDQGS--FLTEDQILP 127 Query: 1089 IFRDICNAVFAMHCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGI 1268 + I + A+H + AHRDLK N+LLG +G L D GS+ N C R Sbjct: 128 LLLGISRGLEAIHAKG--YAHRDLKPTNILLGDEGQPVLMDLGSM--NQACIQVEGSRQA 183 Query: 1269 E--EDIIRKHTTPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFD-----GE 1427 +D + T +YRAPE++ + VI E+ D+W+LGC++Y + + + +D G+ Sbjct: 184 LALQDWAAQRCTISYRAPELFSVQSHCVIDERTDVWSLGCVLYAMMFGEGPYDMVFQKGD 243 Query: 1428 SKLQILNGNYRIPELPKYCSSITSLIEEMLQSSPDARPDITQVWFRVNELLP 1583 S + IP+ P++ S++ L+ M+ P RP I + ++ L P Sbjct: 244 SVALAVQNELSIPQSPRHSSALRQLLSSMMTVDPQQRPHIPVLLSQLEALQP 295
>P51954:NEK1_MOUSE Serine/threonine-protein kinase Nek1 - Mus musculus (Mouse)| Length = 1203 Score = 99.0 bits (245), Expect = 1e-19 Identities = 79/271 (29%), Positives = 131/271 (48%), Gaps = 11/271 (4%) Frame = +3 Query: 777 EAIAEGGFSCVYLARDLTNPAKHYALKHVIVQ---DKESLDLVHKEITVMRALKGHPNVV 947 + I EG F L + T +HY +K + + DKE + +E+ V+ +K HPN+V Sbjct: 8 QKIGEGSFGKAVLVKS-TEDGRHYVIKEINISRMSDKERQES-RREVAVLANMK-HPNIV 64 Query: 948 TLVAHTILDMGRGREALLLMEFCERS-LVSALDARGTAGFYDDEQVALIFRDICNAVFAM 1124 ++M++CE L ++A+ A F +D Q+ F IC A+ Sbjct: 65 QYKE----SFEENGSLYIVMDYCEGGDLFKRINAQKGALFQED-QILDWFVQICLAL--K 117 Query: 1125 HCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHT--- 1295 H + HRD+K++N+ L DG +L DFG R + + T Sbjct: 118 HVHDRKILHRDIKSQNIFLTKDGTVQLGDFGIA------------RVLNSTVELARTCIG 165 Query: 1296 TPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFD-GESK---LQILNGNYRI 1463 TP Y +PE+ + + + K DIWALGC++Y +C LK AF+ G K L+I++G++ Sbjct: 166 TPYYLSPEICE---NKPYNNKSDIWALGCVLYELCTLKHAFEAGNMKNLVLKIISGSFP- 221 Query: 1464 PELPKYCSSITSLIEEMLQSSPDARPDITQV 1556 P P Y + SL+ ++ + +P RP + + Sbjct: 222 PVSPHYSYDLRSLLSQLFKRNPRDRPSVNSI 252
>Q7TSC3:NEK5_MOUSE Serine/threonine-protein kinase Nek5 - Mus musculus (Mouse)| Length = 627 Score = 98.6 bits (244), Expect = 1e-19 Identities = 74/269 (27%), Positives = 130/269 (48%), Gaps = 6/269 (2%) Frame = +3 Query: 768 HVREAIAEGGFSCVYLARDLTNPAKHYALKHV-IVQDKESLDLVHKEITVMRALKGHPNV 944 H+ + I EG F VYLA+D + + H +K + + ++KE+ K ++ A HPN+ Sbjct: 5 HLIKIIGEGTFGKVYLAKDKSE-SSHCVIKEISLTKEKEA----SKNEVILLARMEHPNI 59 Query: 945 VTLVAHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAM 1124 VT + + + GR ++ME+C+ + R + ++Q+ F I ++ Sbjct: 60 VTFFS-SFQENGR---LFIVMEYCDGGDLMQRIQRQRGVMFSEDQILCWFVQI--SLGLK 113 Query: 1125 HCQTPPVAHRDLKAENVLLGADG-AWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHTTP 1301 H + HRD+K++N+ L +G KL DFG+ T + + + TP Sbjct: 114 HIHDRKILHRDIKSQNIFLSKNGMVAKLGDFGTARTLNDSMELAQTCA---------GTP 164 Query: 1302 AYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGES----KLQILNGNYRIPE 1469 Y +PE + + + K DIW+LGC++Y +C LK F+ + L+I G P Sbjct: 165 YYLSPE---ICQNRPYNNKTDIWSLGCVLYELCTLKHPFESNNFHHLVLKICQGRV-API 220 Query: 1470 LPKYCSSITSLIEEMLQSSPDARPDITQV 1556 P + + SLI ++ + SP RP +T + Sbjct: 221 SPHFSRDLQSLIPQLFRVSPQDRPSVTSL 249
>Q6P3R8:NEK5_HUMAN Serine/threonine-protein kinase Nek5 - Homo sapiens (Human)| Length = 708 Score = 94.7 bits (234), Expect = 2e-18 Identities = 80/292 (27%), Positives = 141/292 (48%), Gaps = 11/292 (3%) Frame = +3 Query: 762 KVHVREAIAEGGFSCVYLARDLTNPAKHYALKHVI-----VQDKESLDLVHKEITVMRAL 926 K V +AI +G F YLA+ ++ +KH +K + +Q+KE+ KE+ ++ + Sbjct: 3 KYDVIKAIGQGAFGKAYLAKGKSD-SKHCVIKEINFEKMPIQEKEASK---KEVILLEKM 58 Query: 927 KGHPNVVTLVAHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDIC 1106 K HPN+V ++ + GR ++ME+C+ + R + ++Q+ F I Sbjct: 59 K-HPNIVAFF-NSFQENGR---LFIVMEYCDGGDLMKRINRQRGVLFSEDQILGWFVQI- 112 Query: 1107 NAVFAMHCQTPPVAHRDLKAENVLLGADG-AWKLCDFGSVSTNHKCFDKPEERGIEEDII 1283 ++ H + HRD+KA+N+ L +G KL DFG + + + I Sbjct: 113 -SLGLKHIHDRKILHRDIKAQNIFLSKNGMVAKLGDFGIARVLNNSME------LARTCI 165 Query: 1284 RKHTTPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQI---LNGN 1454 TP Y +PE + + + + K DIW+LGC++Y +C LK F+G + Q+ + Sbjct: 166 G---TPYYLSPE---ICQNKPYNNKTDIWSLGCVLYELCTLKHPFEGNNLQQLVLKICQA 219 Query: 1455 YRIPELPKYCSSITSLIEEMLQSSPDARPDITQVWFR--VNELLPLELQKDL 1604 + P P + + SLI ++ Q SP RP I + R + L+P L ++ Sbjct: 220 HFAPISPGFSRELHSLISQLFQVSPRDRPSINSILKRPFLENLIPKYLTPEV 271
>Q96PY6:NEK1_HUMAN Serine/threonine-protein kinase Nek1 - Homo sapiens (Human)| Length = 1258 Score = 90.1 bits (222), Expect = 5e-17 Identities = 73/270 (27%), Positives = 125/270 (46%), Gaps = 10/270 (3%) Frame = +3 Query: 777 EAIAEGGFSCVYLARDLTNPAKHYALKHVIVQDKESLDLVH--KEITVMRALKGHPNVVT 950 + I EG F L + T + Y +K + + S + +E+ V+ +K HPN+V Sbjct: 8 QKIGEGSFGKAILVKS-TEDGRQYVIKEINISRMSSKEREESRREVAVLANMK-HPNIVQ 65 Query: 951 LVAHTILDMGRGREALLLMEFCERS-LVSALDARGTAGFYDDEQVALIFRDICNAVFAMH 1127 ++M++CE L ++A+ F +D Q+ F IC A+ H Sbjct: 66 YRE----SFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQED-QILDWFVQICLAL--KH 118 Query: 1128 CQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHT---T 1298 + HRD+K++N+ L DG +L DFG R + + T T Sbjct: 119 VHDRKILHRDIKSQNIFLTKDGTVQLGDFGIA------------RVLNSTVELARTCIGT 166 Query: 1299 PAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESK----LQILNGNYRIP 1466 P Y +PE+ + + + K DIWALGC++Y +C LK AF+ S L+I++G++ P Sbjct: 167 PYYLSPEICE---NKPYNNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFP-P 222 Query: 1467 ELPKYCSSITSLIEEMLQSSPDARPDITQV 1556 Y + SL+ ++ + +P RP + + Sbjct: 223 VSLHYSYDLRSLVSQLFKRNPRDRPSVNSI 252
>Q5RAJ5:STK36_PONPY Serine/threonine-protein kinase 36 - Pongo pygmaeus (Orangutan)| Length = 1315 Score = 89.4 bits (220), Expect = 8e-17 Identities = 72/258 (27%), Positives = 123/258 (47%), Gaps = 5/258 (1%) Frame = +3 Query: 762 KVHVREAIAEGGFSCVYLARDLTNPAKHYALKHV--IVQDKESLDLVHKEITVMRALKGH 935 K HV E I EG F VY R + A+ ALK + + + ++ L + +EI +MR L+ H Sbjct: 3 KYHVLEMIGEGSFGRVYKGRRKYS-AQVVALKFIPKLGRSEKELRNLQREIEIMRGLR-H 60 Query: 936 PNVVTLVAHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAV 1115 PN+V H + +E +++ ++ E L+ L+ G ++QV I + +A+ Sbjct: 61 PNIV----HMLDSFETDKEVVVVTDYAEGELLQILEDDGKL---PEDQVQAIAAQLVSAL 113 Query: 1116 FAMHCQTPPVAHRDLKAENVLLGADGAWKLCDFG---SVSTNHKCFDKPEERGIEEDIIR 1286 + +H + HRD+K +N+LL G KLCDFG ++STN + Sbjct: 114 YYLHSHR--ILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTSIK---------- 161 Query: 1287 KHTTPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQILNGNYRIP 1466 TP Y +PE L D+W++GC++Y + F S Q+++ + P Sbjct: 162 --GTPLYMSPE---LVEERPYDHTADLWSVGCILYELAVGTPPFYATSIFQLVSLILKDP 216 Query: 1467 ELPKYCSSITSLIEEMLQ 1520 ++ S+I+ + LQ Sbjct: 217 --VRWPSTISPCFKNFLQ 232
>Q9NRP7:STK36_HUMAN Serine/threonine-protein kinase 36 - Homo sapiens (Human)| Length = 1315 Score = 88.6 bits (218), Expect = 1e-16 Identities = 72/258 (27%), Positives = 122/258 (47%), Gaps = 5/258 (1%) Frame = +3 Query: 762 KVHVREAIAEGGFSCVYLARDLTNPAKHYALKHV--IVQDKESLDLVHKEITVMRALKGH 935 K HV E I EG F VY R + A+ ALK + + + ++ L + +EI +MR L+ H Sbjct: 3 KYHVLEMIGEGSFGRVYKGRRKYS-AQVVALKFIPKLGRSEKELRNLQREIEIMRGLR-H 60 Query: 936 PNVVTLVAHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAV 1115 PN+V H + +E +++ ++ E L L+ G ++QV I + +A+ Sbjct: 61 PNIV----HMLDSFETDKEVVVVTDYAEGELFQILEDDGKL---PEDQVQAIAAQLVSAL 113 Query: 1116 FAMHCQTPPVAHRDLKAENVLLGADGAWKLCDFG---SVSTNHKCFDKPEERGIEEDIIR 1286 + +H + HRD+K +N+LL G KLCDFG ++STN + Sbjct: 114 YYLHSHR--ILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTSIK---------- 161 Query: 1287 KHTTPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQILNGNYRIP 1466 TP Y +PE L D+W++GC++Y + F S Q+++ + P Sbjct: 162 --GTPLYMSPE---LVEERPYDHTADLWSVGCILYELAVGTPPFYATSIFQLVSLILKDP 216 Query: 1467 ELPKYCSSITSLIEEMLQ 1520 ++ S+I+ + LQ Sbjct: 217 --VRWPSTISPCFKNFLQ 232
>Q05512:MARK2_MOUSE Serine/threonine-protein kinase MARK2 - Mus musculus (Mouse)| Length = 776 Score = 86.3 bits (212), Expect = 7e-16 Identities = 87/301 (28%), Positives = 141/301 (46%), Gaps = 14/301 (4%) Frame = +3 Query: 750 VGNVKVHVREAIAEGGFSCVYLARDLTNPAKHYALKHV--IVQDKESLDLVHKEITVMRA 923 +GN ++ + I +G F+ V LAR + K A+K + + SL + +E+ +M+ Sbjct: 50 IGNYRL--LKTIGKGNFAKVKLARHILT-GKEVAVKIIDKTQLNSSSLQKLFREVRIMKV 106 Query: 924 LKGHPNVVTLVAHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDI 1103 L HPN+V L + + L+ME+ V D G +++ FR I Sbjct: 107 LN-HPNIVKLFEVIETE----KTLYLVMEYASGGEV--FDYLVAHGRMKEKEARAKFRQI 159 Query: 1104 CNAVFAMHCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDII 1283 +AV +C + HRDLKAEN+LL AD K+ DFG F G + D Sbjct: 160 VSAV--QYCHQKFIVHRDLKAENLLLDADMNIKIADFG--------FSNEFTFGNKLDTF 209 Query: 1284 RKHTTPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDG----ESKLQILNG 1451 +P Y APE++ +++ +VD+W+LG ++Y + FDG E + ++L G Sbjct: 210 --CGSPPYAAPELFQ--GKKIDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRG 265 Query: 1452 NYRIPELPKYCSSITSLIEEMLQSSPDARPDITQV----WFRV----NELLPLELQKDLP 1607 YRIP + +L+++ L +P R + Q+ W V +EL P + LP Sbjct: 266 KYRIPFY--MSTDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKP--YVEPLP 321 Query: 1608 D 1610 D Sbjct: 322 D 322
>Q69ZM6:STK36_MOUSE Serine/threonine-protein kinase 36 - Mus musculus (Mouse)| Length = 1268 Score = 85.9 bits (211), Expect = 9e-16 Identities = 67/234 (28%), Positives = 110/234 (47%), Gaps = 5/234 (2%) Frame = +3 Query: 762 KVHVREAIAEGGFSCVYLARDLTNPAKHYALKHV--IVQDKESLDLVHKEITVMRALKGH 935 K HV E I EG F VY R + A+ ALK + + + ++ L + +EI +MR L H Sbjct: 3 KYHVLEMIGEGSFGRVYKGRKKYS-AQVVALKFIPKLGRSEKELRNLQREIEIMRGL-WH 60 Query: 936 PNVVTLVAHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAV 1115 PN+V H + +E +++ ++ E L L+ G ++QV I + +A+ Sbjct: 61 PNIV----HMLDSFETDKEVVVVTDYAEGELFQILEDDGKL---PEDQVQAIAAQLVSAL 113 Query: 1116 FAMHCQTPPVAHRDLKAENVLLGADGAWKLCDFG---SVSTNHKCFDKPEERGIEEDIIR 1286 + +H + HRD+K +N+LL G KLCDFG ++STN + Sbjct: 114 YYLHSHR--ILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTSIK---------- 161 Query: 1287 KHTTPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQILN 1448 TP Y +PE L D+W++GC++Y + F S Q+++ Sbjct: 162 --GTPLYMSPE---LVEERPYDHTADLWSVGCILYELAVGTPPFYTTSIFQLVS 210
>Q8TD08:MK15_HUMAN Mitogen-activated protein kinase 15 - Homo sapiens (Human)| Length = 544 Score = 85.5 bits (210), Expect = 1e-15 Identities = 67/227 (29%), Positives = 110/227 (48%), Gaps = 2/227 (0%) Frame = +3 Query: 771 VREAIAEGGFSCVYLARDLTNPAKHYALKHVI--VQDKESLDLVHKEITVMRALKGHPNV 944 +R + +G + V+ A D + A+K + +DK +EIT+++ HPN+ Sbjct: 15 LRRQLGQGAYGIVWKAVD-RRTGEVVAIKKIFDAFRDKTDAQRTFREITLLQEFGDHPNI 73 Query: 945 VTLVAHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAM 1124 ++L+ ++ R+ L+ EF + L +A+ +G G D V IF + A + Sbjct: 74 ISLL--DVIRAENDRDIYLVFEFMDTDL-NAVIRKG--GLLQDVHVRSIFYQLLRATRFL 128 Query: 1125 HCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHTTPA 1304 H + V HRD K NVLL A+ KLCDFG + + PE++ + E + T Sbjct: 129 H--SGHVVHRDQKPSNVLLDANCTVKLCDFGLARSLGDLPEGPEDQAVTEYV----ATRW 182 Query: 1305 YRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQIL 1445 YRAPE+ R + VD+W+LGC++ + + F G S L L Sbjct: 183 YRAPEVLLSSHRYTLG--VDMWSLGCILGEMLRGRPLFPGTSTLHQL 227
>O08679:MARK2_RAT Serine/threonine-protein kinase MARK2 - Rattus norvegicus (Rat)| Length = 722 Score = 84.7 bits (208), Expect = 2e-15 Identities = 87/301 (28%), Positives = 140/301 (46%), Gaps = 14/301 (4%) Frame = +3 Query: 750 VGNVKVHVREAIAEGGFSCVYLARDLTNPAKHYALKHV--IVQDKESLDLVHKEITVMRA 923 +GN ++ + I +G F+ V LAR + K A+K + + SL + +E+ +M+ Sbjct: 50 IGNYRL--LKTIGKGNFAKVKLARHILT-GKEVAVKIIDKTQLNSSSLQKLFREVRIMKV 106 Query: 924 LKGHPNVVTLVAHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDI 1103 L HPN+V L + + L+ME+ V D G +++ FR I Sbjct: 107 LN-HPNIVKLFEVIETE----KTLYLVMEYASGGEV--FDYLVAHGRMKEKEARAKFRQI 159 Query: 1104 CNAVFAMHCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDII 1283 +AV +C + HRDLKAEN+LL AD K+ DFG F G + D Sbjct: 160 VSAV--QYCHQKFIVHRDLKAENLLLDADMNIKIADFG--------FSNEFTFGNKLDTF 209 Query: 1284 RKHTTPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDG----ESKLQILNG 1451 +P Y APE++ ++ +VD+W+LG ++Y + FDG E + ++L G Sbjct: 210 --CGSPPYAAPELFQ--GKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRG 265 Query: 1452 NYRIPELPKYCSSITSLIEEMLQSSPDARPDITQV----WFRV----NELLPLELQKDLP 1607 YRIP + +L+++ L +P R + Q+ W V +EL P + LP Sbjct: 266 KYRIPFY--MSTDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKP--YVEPLP 321 Query: 1608 D 1610 D Sbjct: 322 D 322
>Q7KZI7:MARK2_HUMAN Serine/threonine-protein kinase MARK2 - Homo sapiens (Human)| Length = 788 Score = 84.7 bits (208), Expect = 2e-15 Identities = 87/301 (28%), Positives = 140/301 (46%), Gaps = 14/301 (4%) Frame = +3 Query: 750 VGNVKVHVREAIAEGGFSCVYLARDLTNPAKHYALKHV--IVQDKESLDLVHKEITVMRA 923 +GN ++ + I +G F+ V LAR + K A+K + + SL + +E+ +M+ Sbjct: 50 IGNYRL--LKTIGKGNFAKVKLARHILT-GKEVAVKIIDKTQLNSSSLQKLFREVRIMKV 106 Query: 924 LKGHPNVVTLVAHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDI 1103 L HPN+V L + + L+ME+ V D G +++ FR I Sbjct: 107 LN-HPNIVKLFEVIETE----KTLYLVMEYASGGEV--FDYLVAHGRMKEKEARAKFRQI 159 Query: 1104 CNAVFAMHCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDII 1283 +AV +C + HRDLKAEN+LL AD K+ DFG F G + D Sbjct: 160 VSAV--QYCHQKFIVHRDLKAENLLLDADMNIKIADFG--------FSNEFTFGNKLDTF 209 Query: 1284 RKHTTPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDG----ESKLQILNG 1451 +P Y APE++ ++ +VD+W+LG ++Y + FDG E + ++L G Sbjct: 210 --CGSPPYAAPELFQ--GKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRG 265 Query: 1452 NYRIPELPKYCSSITSLIEEMLQSSPDARPDITQV----WFRV----NELLPLELQKDLP 1607 YRIP + +L+++ L +P R + Q+ W V +EL P + LP Sbjct: 266 KYRIPFY--MSTDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKP--YVEPLP 321 Query: 1608 D 1610 D Sbjct: 322 D 322
>Q8BZN4:NUAK2_MOUSE NUAK family SNF1-like kinase 2 - Mus musculus (Mouse)| Length = 639 Score = 84.3 bits (207), Expect = 3e-15 Identities = 85/300 (28%), Positives = 136/300 (45%), Gaps = 17/300 (5%) Frame = +3 Query: 777 EAIAEGGFSCVYLARDLTNPAKHYALKHVI---VQDKESLDLVHKEITVMRALKGHPNVV 947 E + +G + V AR+ + + A+K + ++D++ L + +EI +M +L HP+++ Sbjct: 61 ETLGKGTYGKVKKARE--SSGRLVAIKSIRKDKIKDEQDLLHIRREIEIMSSLN-HPHII 117 Query: 948 TLVAHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICN----AV 1115 I ++GR R + + +V +RG Y E+ L RD + V Sbjct: 118 A-----IHEVGRSRLVTVFENSSKIVIVMEYASRGDLYDYISERPRLSERDARHFFRQIV 172 Query: 1116 FAMH-CQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKH 1292 A+H C + HRDLK EN+LL A+G K+ DFG + HK G Sbjct: 173 SALHYCHQNGIVHRDLKLENILLDANGNIKIADFGLSNLYHKGKFLQTFCG--------- 223 Query: 1293 TTPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESK----LQILNGNYR 1460 +P Y +PE+ + + + +VD W+LG L+Y + + FDG+ QI NG YR Sbjct: 224 -SPLYASPEI--VNGKPYVGPEVDSWSLGVLLYILVHGTMPFDGQDHKTLVKQISNGAYR 280 Query: 1461 IPELPKYCSSITSLIEEMLQSSPDARPDITQV----WFRVNELLPLELQKDLPDGS-PSG 1625 P P S LI +L +P R + V W + Q+ L +G PSG Sbjct: 281 EPPKP---SDACGLIRWLLMVNPTRRATLEDVASHWWVNWGYTTGVGEQEALREGGHPSG 337
>Q08942:NRKA_TRYBB Putative serine/threonine-protein kinase A - Trypanosoma brucei| brucei Length = 431 Score = 84.3 bits (207), Expect = 3e-15 Identities = 82/318 (25%), Positives = 144/318 (45%), Gaps = 11/318 (3%) Frame = +3 Query: 762 KVHVREAIAEGGFSCVYLARDLTNPAKHYALKHVIVQDKESLDLVHKEITVMRALKGHPN 941 + +V E++ +G CV DL+ ++ +DK EI + A HPN Sbjct: 33 EAYVAESVEDGSL-CVAKVMDLSKMSQ---------RDKR---YAQSEIKCL-ANCNHPN 78 Query: 942 VVTLVAHTILDMGRGREALLLMEFCERSLVSA---LDARGTAGFYDDEQVALIFRDICNA 1112 ++ + D L++MEF + + L G A ++ + + +F +C A Sbjct: 79 IIRYIE----DHEENDRLLIVMEFADSGNLDEQIKLRGSGDARYFQEHEALFLFLQLCLA 134 Query: 1113 VFAMHCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKH 1292 + +H + HRD+K+ NVLL + G KL DFG F E + + Sbjct: 135 LDYIHSHK--MLHRDIKSANVLLTSTGLVKLGDFG--------FSHQYEDTVSGVVASTF 184 Query: 1293 T-TPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGES----KLQILNGNY 1457 TP Y APE+W+ R ++K D+W+LG L+Y I +K F + ++L G Y Sbjct: 185 CGTPYYLAPELWNNKR---YNKKADVWSLGVLLYEIMGMKKPFSASNLKGLMSKVLAGTY 241 Query: 1458 RIPELPKYCSSITSLIEEMLQSSPDARPDITQVWF--RVNELLPLELQKDLPDGSPSGSA 1631 P + S +++ +L + P+ RP + +++ +N+ L L +Q + S S Sbjct: 242 -APLPDSFSSEFKRVVDGILVADPNDRPSVREIFQIPYINKGLKLFVQALKKNERISDSV 300 Query: 1632 FELQITE-HEGLASSILP 1682 E+ +T+ E L+S + P Sbjct: 301 KEVLVTQVSEILSSEVSP 318
>Q10078:PPK13_SCHPO Serine/threonine-protein kinase ppk13 - Schizosaccharomyces pombe| (Fission yeast) Length = 344 Score = 84.0 bits (206), Expect = 4e-15 Identities = 74/315 (23%), Positives = 133/315 (42%), Gaps = 41/315 (13%) Frame = +3 Query: 750 VGNVKVHVREAIAEGGFSCVYLARDLTNPAKHYALKHVIVQ-DKESLDLVHKEITVMRAL 926 + N + +++ + EGGF+ VYL ++++N K YALK + + + KE R Sbjct: 27 INNERYRIQKLLGEGGFAFVYLVQNVSNE-KLYALKKIKCSFGNKGIKKAMKEADYHRKF 85 Query: 927 KGHPNVVTLVAHTILDMGRGREALLLM--EFCERSLVSALDARGTAGFYDDEQVALIFRD 1100 K + ++ H ++ G E + ++ F + S+ + G Y E+ L++ Sbjct: 86 KSN-YLLKSYTHQLVKEADGSEFVYILFPYFAKGSVAQVIRNCDIEGSYISEKRILVWCS 144 Query: 1101 -ICNAVFAMH---------------------CQTPP---------VAHRDLKAENVLLGA 1187 +C A+ +H Q P H D+K +N+LL Sbjct: 145 CLCKALQYLHENVAGDSPKQPEVNDLIMFDEPQVPQNTSNNNLVSYIHGDIKPDNLLLHE 204 Query: 1188 DGAW-KLCDFGSVSTNHKCFDKPEERGIEEDIIRKHTTPAYRAPEMWDLYRREVISEKVD 1364 + L DFGS+ E +D ++ T +RAPE++ + I+EK D Sbjct: 205 NSREIVLTDFGSICLVPIFASNNSEAIAIQDKASENCTMPFRAPELFHVKAGSTITEKAD 264 Query: 1365 IWALGCLMYRICYLKSAFD------GESKLQILNGNYRIPELPKYCSSITSLIEEMLQSS 1526 IW+ GC +Y I + S F+ G L + N Y P Y + + ++E LQ Sbjct: 265 IWSFGCTLYTIMFHASPFEREVSQGGSLALAVCNAQYSFPRKHPYSTLLCEIVEACLQRE 324 Query: 1527 PDARPDITQVWFRVN 1571 P+ RP ++ +++ Sbjct: 325 PNKRPSARELLSKID 339
>O08678:MARK1_RAT Serine/threonine-protein kinase MARK1 - Rattus norvegicus (Rat)| Length = 793 Score = 84.0 bits (206), Expect = 4e-15 Identities = 86/302 (28%), Positives = 142/302 (47%), Gaps = 15/302 (4%) Frame = +3 Query: 750 VGNVKVHVREAIAEGGFSCVYLARDLTNPAKHYALKHV--IVQDKESLDLVHKEITVMRA 923 +GN ++ ++ I +G F+ V LAR + + A+K + + SL + +E+ +M+ Sbjct: 57 IGNYRL--QKTIGKGNFAKVKLARHVLT-GREVAVKIIDKTQLNPTSLQKLFREVRIMKI 113 Query: 924 LKGHPNVVTLVAHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDI 1103 L HPN+V L + + L+ME+ V D G +++ FR I Sbjct: 114 LN-HPNIVKLFEVIETE----KTLYLVMEYASGGEV--FDYLVAHGRMKEKEARAKFRQI 166 Query: 1104 CNAVFAMHCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDII 1283 +AV +C + HRDLKAEN+LL AD K+ DFG F G + D Sbjct: 167 VSAV--QYCHQKCIVHRDLKAENLLLDADMNIKIADFG--------FSNEFTVGNKLDTF 216 Query: 1284 RKHTTPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDG----ESKLQILNG 1451 +P Y APE++ ++ +VD+W+LG ++Y + FDG E + ++L G Sbjct: 217 --CGSPPYAAPELFQ--GKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRG 272 Query: 1452 NYRIPELPKYCSSITSLIEEMLQSSPDARPDITQV----WFRV----NELLPL-ELQKDL 1604 YR+P + +L++++L +P R + Q+ W V EL P E + DL Sbjct: 273 KYRVPFY--MSTDCENLLKKLLVLNPIKRGSLEQIMKDRWMNVGHEEEELKPYSEPELDL 330 Query: 1605 PD 1610 D Sbjct: 331 ND 332
>Q8VHJ5:MARK1_MOUSE Serine/threonine-protein kinase MARK1 - Mus musculus (Mouse)| Length = 795 Score = 84.0 bits (206), Expect = 4e-15 Identities = 86/302 (28%), Positives = 142/302 (47%), Gaps = 15/302 (4%) Frame = +3 Query: 750 VGNVKVHVREAIAEGGFSCVYLARDLTNPAKHYALKHV--IVQDKESLDLVHKEITVMRA 923 +GN ++ ++ I +G F+ V LAR + + A+K + + SL + +E+ +M+ Sbjct: 57 IGNYRL--QKTIGKGNFAKVKLARHVLT-GREVAVKIIDKTQLNPTSLQKLFREVRIMKI 113 Query: 924 LKGHPNVVTLVAHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDI 1103 L HPN+V L + + L+ME+ V D G +++ FR I Sbjct: 114 LN-HPNIVKLFEVIETE----KTLYLVMEYASGGEV--FDYLVAHGRMKEKEARAKFRQI 166 Query: 1104 CNAVFAMHCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDII 1283 +AV +C + HRDLKAEN+LL AD K+ DFG F G + D Sbjct: 167 VSAV--QYCHQKCIVHRDLKAENLLLDADMNIKIADFG--------FSNEFTVGNKLDTF 216 Query: 1284 RKHTTPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDG----ESKLQILNG 1451 +P Y APE++ ++ +VD+W+LG ++Y + FDG E + ++L G Sbjct: 217 --CGSPPYAAPELFQ--GKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRG 272 Query: 1452 NYRIPELPKYCSSITSLIEEMLQSSPDARPDITQV----WFRV----NELLPL-ELQKDL 1604 YR+P + +L++++L +P R + Q+ W V EL P E + DL Sbjct: 273 KYRVPFY--MSTDCENLLKKLLVLNPIKRGSLEQIMKDRWMNVGHEEEELKPYSEPELDL 330 Query: 1605 PD 1610 D Sbjct: 331 ND 332
>P97756:KKCC1_RAT Calcium/calmodulin-dependent protein kinase kinase 1 - Rattus| norvegicus (Rat) Length = 505 Score = 84.0 bits (206), Expect = 4e-15 Identities = 74/262 (28%), Positives = 119/262 (45%), Gaps = 4/262 (1%) Frame = +3 Query: 885 LDLVHKEITVMRALKGHPNVVTLVAHTILDMGRGREALLLMEFCERSLVSALDARGTAGF 1064 L+ V++EI +++ L H NVV L+ +LD L+ + + V + Sbjct: 193 LERVYQEIAILKKLD-HVNVVKLIE--VLDDPAEDNLYLVFDLLRKGPVMEVPCDKP--- 246 Query: 1065 YDDEQVALIFRDICNAVFAMHCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCF 1244 + +EQ L RDI + +HCQ + HRD+K N+LLG DG K+ DFG VS + Sbjct: 247 FPEEQARLYLRDIILGLEYLHCQK--IVHRDIKPSNLLLGDDGHVKIADFG-VSNQFE-- 301 Query: 1245 DKPEERGIEEDIIRKHTTPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDG 1424 G + + TPA+ APE + + +D+WA G +Y Y K F Sbjct: 302 ------GNDAQLSSTAGTPAFMAPEAISDTGQSFSGKALDVWATGVTLYCFVYGKCPFID 355 Query: 1425 ESKL----QILNGNYRIPELPKYCSSITSLIEEMLQSSPDARPDITQVWFRVNELLPLEL 1592 E L +I N PE P+ + LI +ML +P+ R ++ + +++ + Sbjct: 356 EYILALHRKIKNEAVVFPEEPEVSEELKDLILKMLDKNPETRIGVSDI--KLHPWVTKHG 413 Query: 1593 QKDLPDGSPSGSAFELQITEHE 1658 ++ LP S E +TE E Sbjct: 414 EEPLPSEEEHCSVVE--VTEEE 433
>Q6NSM8:QSK_DANRE Serine/threonine-protein kinase QSK homolog - Danio rerio (Zebrafish)| (Brachydanio rerio) Length = 1187 Score = 83.6 bits (205), Expect = 5e-15 Identities = 80/276 (28%), Positives = 129/276 (46%), Gaps = 11/276 (3%) Frame = +3 Query: 771 VREAIAEGGFSCVYLARDLTNPAKHYALKHV--IVQDKESLDLVHKEITVMRALKGHPNV 944 + I +G F+ V LA + AK A+K V D E+L + +E+ +M+ L+ HP++ Sbjct: 61 MERTIGKGNFAVVKLATHMITKAK-VAIKIVDKTQLDDENLKKIFREVQIMKMLR-HPHI 118 Query: 945 VTLVAHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAM 1124 + L M R L+ E+ + D G ++ F+ I AV+ Sbjct: 119 IRLYQV----METERMIYLVTEYASGGEI--FDHLVAHGRMAEKDARRKFKQIVAAVYFC 172 Query: 1125 HCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHT-TP 1301 HC++ + HRDLKAEN+LL + K+ DFG F RG +++ +P Sbjct: 173 HCRS--IVHRDLKAENLLLDHNLNIKIADFG--------FSNLFSRG---QLLKTWCGSP 219 Query: 1302 AYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGES----KLQILNGNYRIPE 1469 Y APE+++ +E KVDIW+LG ++Y + FDG + + ++L+G +RIP Sbjct: 220 PYAAPELFE--GKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPF 277 Query: 1470 LPKYCSSITSLIEEMLQSSPDARPDITQV----WFR 1565 + LI ML P R + Q+ W R Sbjct: 278 F--MSTDCEYLIRHMLILEPSRRLSMEQICKNKWMR 311
>Q8CIP4:MARK4_MOUSE MAP/microtubule affinity-regulating kinase 4 - Mus musculus (Mouse)| Length = 752 Score = 83.6 bits (205), Expect = 5e-15 Identities = 78/275 (28%), Positives = 128/275 (46%), Gaps = 6/275 (2%) Frame = +3 Query: 750 VGNVKVHVREAIAEGGFSCVYLARDLTNPAKHYALKHV--IVQDKESLDLVHKEITVMRA 923 VGN ++ I +G F+ V LAR + + A+K + + SL + +E+ +M+ Sbjct: 56 VGNYRL--LRTIGKGNFAKVKLARHILT-GREVAIKIIDKTQLNPSSLQKLFREVRIMKG 112 Query: 924 LKGHPNVVTLVAHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDI 1103 L HPN+V L + + L+ME+ V D + G +++ FR I Sbjct: 113 LN-HPNIVKLFEVIETE----KTLYLVMEYASAGEV--FDYLVSHGRMKEKEARAKFRQI 165 Query: 1104 CNAVFAMHCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDII 1283 +AV +C + HRDLKAEN+LL A+ K+ DFG F G + D Sbjct: 166 VSAVH--YCHQKNIVHRDLKAENLLLDAEANIKIADFG--------FSNEFTLGSKLDTF 215 Query: 1284 RKHTTPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDG----ESKLQILNG 1451 +P Y APE++ ++ +VDIW+LG ++Y + FDG E + ++L G Sbjct: 216 --CGSPPYAAPELFQ--GKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRG 271 Query: 1452 NYRIPELPKYCSSITSLIEEMLQSSPDARPDITQV 1556 YR+P + S++ L +P R + Q+ Sbjct: 272 KYRVPFY--MSTDCESILRRFLVLNPAKRCTLEQI 304
>Q96L34:MARK4_HUMAN MAP/microtubule affinity-regulating kinase 4 - Homo sapiens (Human)| Length = 752 Score = 83.6 bits (205), Expect = 5e-15 Identities = 78/275 (28%), Positives = 128/275 (46%), Gaps = 6/275 (2%) Frame = +3 Query: 750 VGNVKVHVREAIAEGGFSCVYLARDLTNPAKHYALKHV--IVQDKESLDLVHKEITVMRA 923 VGN ++ I +G F+ V LAR + + A+K + + SL + +E+ +M+ Sbjct: 56 VGNYRL--LRTIGKGNFAKVKLARHILT-GREVAIKIIDKTQLNPSSLQKLFREVRIMKG 112 Query: 924 LKGHPNVVTLVAHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDI 1103 L HPN+V L + + L+ME+ V D + G +++ FR I Sbjct: 113 LN-HPNIVKLFEVIETE----KTLYLVMEYASAGEV--FDYLVSHGRMKEKEARAKFRQI 165 Query: 1104 CNAVFAMHCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDII 1283 +AV +C + HRDLKAEN+LL A+ K+ DFG F G + D Sbjct: 166 VSAVH--YCHQKNIVHRDLKAENLLLDAEANIKIADFG--------FSNEFTLGSKLDTF 215 Query: 1284 RKHTTPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDG----ESKLQILNG 1451 +P Y APE++ ++ +VDIW+LG ++Y + FDG E + ++L G Sbjct: 216 --CGSPPYAAPELFQ--GKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRG 271 Query: 1452 NYRIPELPKYCSSITSLIEEMLQSSPDARPDITQV 1556 YR+P + S++ L +P R + Q+ Sbjct: 272 KYRVPFY--MSTDCESILRRFLVLNPAKRCTLEQI 304
>Q8N5S9:KKCC1_HUMAN Calcium/calmodulin-dependent protein kinase kinase 1 - Homo sapiens| (Human) Length = 505 Score = 83.6 bits (205), Expect = 5e-15 Identities = 72/247 (29%), Positives = 112/247 (45%), Gaps = 8/247 (3%) Frame = +3 Query: 885 LDLVHKEITVMRALKGHPNVVTLVAHTILDMGRGREALLLMEFCERSLVSALDARGTAGF 1064 L+ V++EI +++ L H NVV L+ +LD L+ + + V + Sbjct: 193 LERVYQEIAILKKLD-HVNVVKLIE--VLDDPAEDNLYLVFDLLRKGPVMEVPCDKP--- 246 Query: 1065 YDDEQVALIFRDICNAVFAMHCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCF 1244 + +EQ L RD+ + +HCQ + HRD+K N+LLG DG K+ DFG VS + Sbjct: 247 FSEEQARLYLRDVILGLEYLHCQK--IVHRDIKPSNLLLGDDGHVKIADFG-VSNQFE-- 301 Query: 1245 DKPEERGIEEDIIRKHTTPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDG 1424 G + + TPA+ APE + + +D+WA G +Y Y K F Sbjct: 302 ------GNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFID 355 Query: 1425 ESKL----QILNGNYRIPELPKYCSSITSLIEEMLQSSPDAR---PDI-TQVWFRVNELL 1580 + L +I N PE P+ + LI +ML +P+ R PDI W N Sbjct: 356 DFILALHRKIKNEPVVFPEEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWVTKNGEE 415 Query: 1581 PLELQKD 1601 PL +++ Sbjct: 416 PLPSEEE 422
>Q6P4S6:QSK_MOUSE Serine/threonine-protein kinase QSK - Mus musculus (Mouse)| Length = 1311 Score = 83.2 bits (204), Expect = 6e-15 Identities = 79/282 (28%), Positives = 132/282 (46%), Gaps = 11/282 (3%) Frame = +3 Query: 771 VREAIAEGGFSCVYLARDLTNPAKHYALKHVIVQ--DKESLDLVHKEITVMRALKGHPNV 944 + I +G F+ V A L AK A+K + D+E+L + +E+ +M+ L HP++ Sbjct: 10 IDRTIGKGNFAVVKRATHLVTKAK-VAIKIIDKSQLDEENLKKIFREVQIMKMLC-HPHI 67 Query: 945 VTLVAHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAM 1124 + L M R L+ E+ + D G +++ F+ I AV+ Sbjct: 68 IRLYQV----METERMIYLVTEYASGGEI--FDHLVAHGRMAEKEARRKFKQIVTAVYFC 121 Query: 1125 HCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHT-TP 1301 HC+ + HRDLKAEN+LL A+ K+ DFG F G +++ +P Sbjct: 122 HCRN--IVHRDLKAENLLLDANLNIKIADFG--------FSNLFTPG---QLLKTWCGSP 168 Query: 1302 AYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGES----KLQILNGNYRIPE 1469 Y APE+++ +E KVDIW+LG ++Y + FDG + + ++L+G +RIP Sbjct: 169 PYAAPELFE--GKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPF 226 Query: 1470 LPKYCSSITSLIEEMLQSSPDARPDITQV----WFRVNELLP 1583 + LI ML P+ R + Q+ W ++ + P Sbjct: 227 F--MSTECEHLIRHMLVLDPNKRLSMEQICRHKWMKLGDADP 266
>Q9Y2K2:QSK_HUMAN Serine/threonine-protein kinase QSK - Homo sapiens (Human)| Length = 1263 Score = 83.2 bits (204), Expect = 6e-15 Identities = 79/282 (28%), Positives = 132/282 (46%), Gaps = 11/282 (3%) Frame = +3 Query: 771 VREAIAEGGFSCVYLARDLTNPAKHYALKHV--IVQDKESLDLVHKEITVMRALKGHPNV 944 + I +G F+ V A L AK A+K + D+E+L + +E+ +M+ L HP++ Sbjct: 10 IDRTIGKGNFAVVKRATHLVTKAK-VAIKIIDKTQLDEENLKKIFREVQIMKMLC-HPHI 67 Query: 945 VTLVAHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAM 1124 + L M R L+ E+ + D G +++ F+ I AV+ Sbjct: 68 IRLYQV----METERMIYLVTEYASGGEI--FDHLVAHGRMAEKEARRKFKQIVTAVYFC 121 Query: 1125 HCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHT-TP 1301 HC+ + HRDLKAEN+LL A+ K+ DFG F G +++ +P Sbjct: 122 HCRN--IVHRDLKAENLLLDANLNIKIADFG--------FSNLFTPG---QLLKTWCGSP 168 Query: 1302 AYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGES----KLQILNGNYRIPE 1469 Y APE+++ +E KVDIW+LG ++Y + FDG + + ++L+G +RIP Sbjct: 169 PYAAPELFE--GKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPF 226 Query: 1470 LPKYCSSITSLIEEMLQSSPDARPDITQV----WFRVNELLP 1583 + LI ML P+ R + Q+ W ++ + P Sbjct: 227 F--MSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADP 266
>Q6C7U8:PHO85_YARLI Negative regulator of the PHO system - Yarrowia lipolytica (Candida| lipolytica) Length = 294 Score = 83.2 bits (204), Expect = 6e-15 Identities = 69/236 (29%), Positives = 108/236 (45%), Gaps = 3/236 (1%) Frame = +3 Query: 777 EAIAEGGFSCVYLARDLTNPAKHYALKHVIVQDKESL-DLVHKEITVMRALKGHPNVVTL 953 E + EG ++ VY R+ T + ALK + + +E +EI++M+ LK H N+VTL Sbjct: 11 EKLGEGTYATVYKGRNRTT-GQLVALKEINLDSEEGTPSTAIREISLMKELK-HENIVTL 68 Query: 954 --VAHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAMH 1127 V HT + L+ E+ ++ L +D G G + +QV + + + Sbjct: 69 YDVIHTENKLN------LVFEYMDKDLKKFMDTNGNKGALETKQVKWFMYQLLRGI--LF 120 Query: 1128 CQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHTTPAY 1307 C V HRDLK +N+L+ A G KL DFG + F P E + T Y Sbjct: 121 CHDNRVLHRDLKPQNLLINAKGQLKLADFGLA----RAFGIPVNTFSNEVV-----TLWY 171 Query: 1308 RAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQILNGNYRIPELP 1475 RAP++ L S +DIW+ GC+M + + F G S L +++ P Sbjct: 172 RAPDV--LLGSRTYSTSIDIWSAGCIMAEMFTGRPLFPGSSNDDQLQHIFKLMGTP 225
>Q03141:MARK3_MOUSE MAP/microtubule affinity-regulating kinase 3 - Mus musculus (Mouse)| Length = 753 Score = 82.8 bits (203), Expect = 8e-15 Identities = 78/275 (28%), Positives = 129/275 (46%), Gaps = 6/275 (2%) Frame = +3 Query: 750 VGNVKVHVREAIAEGGFSCVYLARDLTNPAKHYALKHV--IVQDKESLDLVHKEITVMRA 923 +GN ++ + I +G F+ V LAR + + A+K + + SL + +E+ +M+ Sbjct: 53 IGNYRL--LKTIGKGNFAKVKLARHILT-GREVAIKIIDKTQLNPTSLQKLFREVRIMKI 109 Query: 924 LKGHPNVVTLVAHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDI 1103 L HPN+V L + + L+ME+ V D G +++ FR I Sbjct: 110 LN-HPNIVKLFEVIETE----KTLYLIMEYASGGEV--FDYLVAHGRMKEKEARAKFRQI 162 Query: 1104 CNAVFAMHCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDII 1283 +AV +C + HRDLKAEN+LL AD K+ DFG F G + D Sbjct: 163 VSAV--QYCHQKRIVHRDLKAENLLLDADMNIKIADFG--------FSNEFTVGSKLDTF 212 Query: 1284 RKHTTPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDG----ESKLQILNG 1451 +P Y APE++ ++ +VD+W+LG ++Y + FDG E + ++L G Sbjct: 213 --CGSPPYAAPELFQ--GKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRG 268 Query: 1452 NYRIPELPKYCSSITSLIEEMLQSSPDARPDITQV 1556 YRIP + +L++ L +P R + Q+ Sbjct: 269 KYRIPFY--MSTDCENLLKRFLVLNPVKRGTLEQI 301
>Q8VHF0:MARK3_RAT MAP/microtubule affinity-regulating kinase 3 - Rattus norvegicus| (Rat) Length = 797 Score = 82.4 bits (202), Expect = 1e-14 Identities = 78/275 (28%), Positives = 129/275 (46%), Gaps = 6/275 (2%) Frame = +3 Query: 750 VGNVKVHVREAIAEGGFSCVYLARDLTNPAKHYALKHV--IVQDKESLDLVHKEITVMRA 923 +GN ++ + I +G F+ V LAR + + A+K + + SL + +E+ +M+ Sbjct: 53 IGNYRL--LKTIGKGNFAKVKLARHILT-GREVAIKIIDKTQLNPTSLQKLFREVRIMKI 109 Query: 924 LKGHPNVVTLVAHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDI 1103 L HPN+V L + + L+ME+ V D G +++ FR I Sbjct: 110 LN-HPNIVKLFEVIETE----KTLYLIMEYASGGEV--FDYLVAHGRMKEKEARAKFRQI 162 Query: 1104 CNAVFAMHCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDII 1283 +AV +C + HRDLKAEN+LL AD K+ DFG F G + D Sbjct: 163 VSAV--QYCHQKRIVHRDLKAENLLLDADMNIKITDFG--------FSNEFTVGSKLDTF 212 Query: 1284 RKHTTPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDG----ESKLQILNG 1451 +P Y APE++ ++ +VD+W+LG ++Y + FDG E + ++L G Sbjct: 213 --CGSPPYAAPELFQ--GKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRG 268 Query: 1452 NYRIPELPKYCSSITSLIEEMLQSSPDARPDITQV 1556 YRIP + +L++ L +P R + Q+ Sbjct: 269 KYRIPFY--MSTDCENLLKRFLVLNPVKRGTLEQI 301
>Q8VBY2:KKCC1_MOUSE Calcium/calmodulin-dependent protein kinase kinase 1 - Mus musculus| (Mouse) Length = 505 Score = 82.4 bits (202), Expect = 1e-14 Identities = 73/262 (27%), Positives = 118/262 (45%), Gaps = 4/262 (1%) Frame = +3 Query: 885 LDLVHKEITVMRALKGHPNVVTLVAHTILDMGRGREALLLMEFCERSLVSALDARGTAGF 1064 L+ V++EI +++ L H NVV L+ +LD L+ + + V + Sbjct: 193 LERVYQEIAILKKLD-HVNVVKLIE--VLDDPAEDNLYLVFDLLRKGPVMEVPCDKP--- 246 Query: 1065 YDDEQVALIFRDICNAVFAMHCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCF 1244 + +EQ L RDI + +HCQ + HRD+K N+LLG DG K+ DFG VS + Sbjct: 247 FPEEQARLYLRDIILGLEYLHCQK--IVHRDIKPSNLLLGDDGHVKIADFG-VSNQFE-- 301 Query: 1245 DKPEERGIEEDIIRKHTTPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDG 1424 G + + TPA+ APE + + +D+WA G +Y Y K F Sbjct: 302 ------GNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFID 355 Query: 1425 ESKL----QILNGNYRIPELPKYCSSITSLIEEMLQSSPDARPDITQVWFRVNELLPLEL 1592 + L +I N PE P+ + LI ML +P+ R ++ + +++ + Sbjct: 356 DYILTLHRKIKNEAVVFPEEPEVSEDLKDLILRMLDKNPETRIGVSDI--KLHPWVTKHG 413 Query: 1593 QKDLPDGSPSGSAFELQITEHE 1658 ++ LP S E +TE E Sbjct: 414 EEPLPSEEEHCSVVE--VTEEE 433
>Q9P0L2:MARK1_HUMAN Serine/threonine-protein kinase MARK1 - Homo sapiens (Human)| Length = 795 Score = 82.0 bits (201), Expect = 1e-14 Identities = 77/275 (28%), Positives = 131/275 (47%), Gaps = 6/275 (2%) Frame = +3 Query: 750 VGNVKVHVREAIAEGGFSCVYLARDLTNPAKHYALKHV--IVQDKESLDLVHKEITVMRA 923 +GN ++ ++ I +G F+ V LAR + + A+K + + SL + +E+ +M+ Sbjct: 57 IGNYRL--QKTIGKGNFAKVKLARHVLT-GREVAVKIIDKTQLNPTSLQKLFREVRIMKI 113 Query: 924 LKGHPNVVTLVAHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDI 1103 L HPN+V L + + L+ME+ V D G +++ FR I Sbjct: 114 LN-HPNIVKLFEVIETE----KTLYLVMEYASGGEV--FDYLVAHGRMKEKEARAKFRQI 166 Query: 1104 CNAVFAMHCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDII 1283 +AV +C + HRDLKAEN+LL D K+ DFG F G + D Sbjct: 167 VSAV--QYCHQKYIVHRDLKAENLLLDGDMNIKIADFG--------FSNEFTVGNKLDTF 216 Query: 1284 RKHTTPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDG----ESKLQILNG 1451 +P Y APE++ ++ +VD+W+LG ++Y + FDG E + ++L G Sbjct: 217 --CGSPPYAAPELFQ--GKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRG 272 Query: 1452 NYRIPELPKYCSSITSLIEEMLQSSPDARPDITQV 1556 YRIP + +L++++L +P R + Q+ Sbjct: 273 KYRIPFY--MSTDCENLLKKLLVLNPIKRGSLEQI 305
>O88831:KKCC2_RAT Calcium/calmodulin-dependent protein kinase kinase 2 - Rattus| norvegicus (Rat) Length = 587 Score = 82.0 bits (201), Expect = 1e-14 Identities = 60/234 (25%), Positives = 109/234 (46%), Gaps = 4/234 (1%) Frame = +3 Query: 867 VQDKESLDLVHKEITVMRALKGHPNVVTLVAHTILDMGRGREALLLMEFCERSLVSALDA 1046 +Q + ++ V++EI +++ L HPNVV LV +LD ++ E + V + Sbjct: 223 IQPRGPIEQVYQEIAILKKLD-HPNVVKLVE--VLDDPNEDHLYMVFELVNQGPVMEVP- 278 Query: 1047 RGTAGFYDDEQVALIFRDICNAVFAMHCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVS 1226 T ++Q F+D+ + +H Q + HRD+K N+L+G DG K+ DFG + Sbjct: 279 --TLKPLSEDQARFYFQDLIKGIEYLHYQK--IIHRDIKPSNLLVGEDGHIKIADFGVSN 334 Query: 1227 TNHKCFDKPEERGIEEDIIRKHTTPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYL 1406 E +G + + TPA+ APE R+ + +D+WA+G +Y + Sbjct: 335 ---------EFKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFG 385 Query: 1407 KSAFDGESKL----QILNGNYRIPELPKYCSSITSLIEEMLQSSPDARPDITQV 1556 + F E + +I + P+ P + LI ML +P++R + ++ Sbjct: 386 QCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEI 439
>Q8C078:KKCC2_MOUSE Calcium/calmodulin-dependent protein kinase kinase 2 - Mus musculus| (Mouse) Length = 588 Score = 82.0 bits (201), Expect = 1e-14 Identities = 60/234 (25%), Positives = 109/234 (46%), Gaps = 4/234 (1%) Frame = +3 Query: 867 VQDKESLDLVHKEITVMRALKGHPNVVTLVAHTILDMGRGREALLLMEFCERSLVSALDA 1046 +Q + ++ V++EI +++ L HPNVV LV +LD ++ E + V + Sbjct: 224 IQPRGPIEQVYQEIAILKKLD-HPNVVKLVE--VLDDPNEDHLYMVFELVNQGPVMEVP- 279 Query: 1047 RGTAGFYDDEQVALIFRDICNAVFAMHCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVS 1226 T ++Q F+D+ + +H Q + HRD+K N+L+G DG K+ DFG + Sbjct: 280 --TLKPLSEDQARFYFQDLIKGIEYLHYQK--IIHRDIKPSNLLVGEDGHIKIADFGVSN 335 Query: 1227 TNHKCFDKPEERGIEEDIIRKHTTPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYL 1406 E +G + + TPA+ APE R+ + +D+WA+G +Y + Sbjct: 336 ---------EFKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFG 386 Query: 1407 KSAFDGESKL----QILNGNYRIPELPKYCSSITSLIEEMLQSSPDARPDITQV 1556 + F E + +I + P+ P + LI ML +P++R + ++ Sbjct: 387 QCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEI 440
>Q96RR4:KKCC2_HUMAN Calcium/calmodulin-dependent protein kinase kinase 2 - Homo sapiens| (Human) Length = 588 Score = 82.0 bits (201), Expect = 1e-14 Identities = 60/234 (25%), Positives = 109/234 (46%), Gaps = 4/234 (1%) Frame = +3 Query: 867 VQDKESLDLVHKEITVMRALKGHPNVVTLVAHTILDMGRGREALLLMEFCERSLVSALDA 1046 +Q + ++ V++EI +++ L HPNVV LV +LD ++ E + V + Sbjct: 224 IQPRGPIEQVYQEIAILKKLD-HPNVVKLVE--VLDDPNEDHLYMVFELVNQGPVMEVP- 279 Query: 1047 RGTAGFYDDEQVALIFRDICNAVFAMHCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVS 1226 T ++Q F+D+ + +H Q + HRD+K N+L+G DG K+ DFG + Sbjct: 280 --TLKPLSEDQARFYFQDLIKGIEYLHYQK--IIHRDIKPSNLLVGEDGHIKIADFGVSN 335 Query: 1227 TNHKCFDKPEERGIEEDIIRKHTTPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYL 1406 E +G + + TPA+ APE R+ + +D+WA+G +Y + Sbjct: 336 ---------EFKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFG 386 Query: 1407 KSAFDGESKL----QILNGNYRIPELPKYCSSITSLIEEMLQSSPDARPDITQV 1556 + F E + +I + P+ P + LI ML +P++R + ++ Sbjct: 387 QCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEI 440
>Q12003:KP236_YEAST Serine/threonine-protein kinase YPL236C - Saccharomyces cerevisiae| (Baker's yeast) Length = 364 Score = 81.6 bits (200), Expect = 2e-14 Identities = 76/340 (22%), Positives = 133/340 (39%), Gaps = 63/340 (18%) Frame = +3 Query: 726 GLEGRTIDVGNVKVHVREAIAEGGFSCVYLARDLTNPA---------KHYALKHVIVQDK 878 G TI V + + ++ + EGG S VYL + N + YALK +I Sbjct: 17 GFSDATIRVNDKRYRIQRLLGEGGMSFVYLVQLSKNSLIIDNGIATPELYALKKIICPSV 76 Query: 879 ESLDLVHKEITVMRALKGHPNVVTLVAHTILDMGRGREAL--LLMEFCERSLVSALDARG 1052 ES+ +EI + + P V+ + ++ G + + +L + SL +++ R Sbjct: 77 ESISNGMREIENYKRFQS-PYVIKSIDSQVMQEKDGSKTIYIVLPYYSLGSLQDSINRRL 135 Query: 1053 TAG-FYDDEQVALIFRDICNAVFAMHC------------------------------QTP 1139 G F + + I + + +H TP Sbjct: 136 LEGTFVSEAECVRIMLGVTRGLLCLHDPASRQDNATSRVNVDAVSMTYSDETAMLLEDTP 195 Query: 1140 --------------PVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEED 1277 AHRD+ N+L +DG + D GS S + + ++ Sbjct: 196 LEMDMLSSNSAGSIAYAHRDITPSNILFSSDGLPVIGDLGSCSQADITIENRHQLSELQE 255 Query: 1278 IIRKHTTPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQ------ 1439 + + T Y PE+ +L +V+S KVDIW+LGC Y + + S F+ E ++ Sbjct: 256 WVNDNCTLPYTPPELLNLKLNQVLSSKVDIWSLGCTFYTLMFGISPFEREEQIHGASLTY 315 Query: 1440 -ILNGNYRIPELPKYCSSITSLIEEMLQSSPDARPDITQV 1556 I G Y P ++ + S+I++ +Q P RP +Q+ Sbjct: 316 AINTGKYSFPRNSRFSEGLLSVIKKCIQVDPIQRPTTSQL 355
>Q60670:SN1L1_MOUSE Serine/threonine-protein kinase SNF1-like kinase 1 - Mus musculus| (Mouse) Length = 779 Score = 81.3 bits (199), Expect = 2e-14 Identities = 87/328 (26%), Positives = 153/328 (46%), Gaps = 11/328 (3%) Frame = +3 Query: 693 LMPKEHSGPSGGLEGRTIDVGNVKVHVREAIAEGGFSCVYLARDLTNPAKHYALKHVIVQ 872 +M + + PSG +G+ + V + +G F+ V LAR + A+K + Sbjct: 3 IMSEFSAVPSGTGQGQQKPLRVGFYDVERTLGKGNFAVVKLARHRVTKTQ-VAIKIIDKT 61 Query: 873 --DKESLDLVHKEITVMRALKGHPNVVTLVAHTILDMGRGREALLLM-EFCERSLVSALD 1043 D +L+ +++E+ +M+ L HPN++ L + +++ ++ L ++ EF + D Sbjct: 62 RLDSSNLEKIYREVQLMKLLN-HPNIIKL--YQVMET---KDMLYIVTEFAKNG--EMFD 113 Query: 1044 ARGTAGFYDDEQVALIFRDICNAVFAMHCQTPPVAHRDLKAENVLLGADGAWKLCDFGSV 1223 + G + + F I +AV +C + HRDLK EN+LL ++ KL DFG Sbjct: 114 YLTSNGHLSENEARQKFWQILSAV--EYCHNHHIVHRDLKTENLLLDSNMDIKLADFGFG 171 Query: 1224 STNHKCFDKPEERGIEEDIIRKHTTPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICY 1403 + F KP E + +P Y APE+++ +E ++D+W+LG ++Y + Sbjct: 172 N-----FYKP-----GEPLSTCVGSPPYAAPEVFE--GKEYEGPQLDVWSLGVVLYVLVC 219 Query: 1404 LKSAFDGES----KLQILNGNYRIPELPKYCSSITSLIEEMLQSSPDARPDITQV----W 1559 FDG + + ++L G +RIP +LI ML P R I Q+ W Sbjct: 220 GSLPFDGPNLPTLRQRVLEGRFRIPFF--MSQDCETLIRRMLVVDPAKRITIAQIRQHRW 277 Query: 1560 FRVNELLPLELQKDLPDGSPSGSAFELQ 1643 + + P LQ+D P AF++Q Sbjct: 278 MQAD---PTLLQQDDP-------AFDMQ 295
>Q6BRY2:PHO85_DEBHA Negative regulator of the PHO system - Debaryomyces hansenii (Yeast)| (Torulaspora hansenii) Length = 330 Score = 81.3 bits (199), Expect = 2e-14 Identities = 71/236 (30%), Positives = 107/236 (45%), Gaps = 3/236 (1%) Frame = +3 Query: 777 EAIAEGGFSCVYLARDLTNPAKHYALKHVIVQDKESL-DLVHKEITVMRALKGHPNVVTL 953 E + EG ++ VY R+ TN + ALK + + +E +EI++M+ L H N+VTL Sbjct: 12 EKLGEGTYATVYKGRNRTN-GQLVALKEINLDSEEGTPSTAIREISLMKELD-HENIVTL 69 Query: 954 --VAHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAMH 1127 V HT + L+ EF ++ L ++A G G D + V + + M Sbjct: 70 YDVIHT------ENKLTLVFEFMDKDLKKYMEAHGNQGALDLKIVKSFIFQLLKGI--MF 121 Query: 1128 CQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHTTPAY 1307 C V HRDLK +N+L+ G KL DFG + F P E + T Y Sbjct: 122 CHDNRVLHRDLKPQNLLINNKGELKLGDFGLA----RAFGIPFNTFSNEVV-----TLWY 172 Query: 1308 RAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQILNGNYRIPELP 1475 RAP++ L + +DIW+ GC+ +C K F G S L +R+ P Sbjct: 173 RAPDV--LLGSRAYTASIDIWSAGCIFAEMCTGKPLFPGTSNDDQLIKIFRLMGTP 226
>Q90XC2:NEK8_DANRE Serine/threonine-protein kinase Nek8 - Danio rerio (Zebrafish)| (Brachydanio rerio) Length = 697 Score = 81.3 bits (199), Expect = 2e-14 Identities = 70/287 (24%), Positives = 127/287 (44%), Gaps = 12/287 (4%) Frame = +3 Query: 762 KVHVREAIAEGGFSCVYLARDLTNPAKHYALKHVIVQD--KESLDLVHKEITVMRALKGH 935 K + + G F V+L R T+ A LK + V+ ++ E V++ L H Sbjct: 3 KYEKTKVVGRGAFGIVHLCRRRTDSAL-VILKEIPVEQMTRDERLAAQNECQVLKLLS-H 60 Query: 936 PNVVTLVAHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAV 1115 PN++ + + D + ++ ME+ ++ + D++ + F I A+ Sbjct: 61 PNIIEYYENFLED----KALMIAMEYAPGGTLADYIQKRCNSLLDEDTILHSFVQILLAL 116 Query: 1116 FAMHCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHT 1295 + +H + + HRDLK +N+LL H+ K + GI + ++ K Sbjct: 117 YHVHNKL--ILHRDLKTQNILLD---------------KHQMIVKIGDFGISKILVSKSK 159 Query: 1296 ------TPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGES----KLQIL 1445 TP Y +PE+ + + ++K DIWALGC++Y + LK AF+ + L+I+ Sbjct: 160 AYTVVGTPCYISPELCE---GKPYNQKSDIWALGCVLYELASLKRAFEAANLPALVLKIM 216 Query: 1446 NGNYRIPELPKYCSSITSLIEEMLQSSPDARPDITQVWFRVNELLPL 1586 +G + P +Y + LI ML P RP + ++ + PL Sbjct: 217 SGTF-APISDRYSPELRQLILNMLNLDPSKRPQLNEIMAHAICIRPL 262
>Q9R1U5:SN1L1_RAT Serine/threonine-protein kinase SNF1-like kinase 1 - Rattus| norvegicus (Rat) Length = 776 Score = 80.9 bits (198), Expect = 3e-14 Identities = 86/322 (26%), Positives = 149/322 (46%), Gaps = 11/322 (3%) Frame = +3 Query: 693 LMPKEHSGPSGGLEGRTIDVGNVKVHVREAIAEGGFSCVYLARDLTNPAKHYALKHVIVQ 872 +M + + P+G +G+ + V + +G F+ V LAR + A+K + Sbjct: 3 IMSEFSAVPTGTGQGQQKPLRVGFYDVERTLGKGNFAVVKLARHRVTKTQ-VAIKIIDKT 61 Query: 873 --DKESLDLVHKEITVMRALKGHPNVVTLVAHTILDMGRGREALLLM-EFCERSLVSALD 1043 D +L+ +++E+ +M+ L HPN++ L + +++ ++ L ++ EF + D Sbjct: 62 RLDSSNLEKIYREVQLMKLLN-HPNIIKL--YQVMET---KDMLYIVTEFAKNG--EMFD 113 Query: 1044 ARGTAGFYDDEQVALIFRDICNAVFAMHCQTPPVAHRDLKAENVLLGADGAWKLCDFGSV 1223 + G + + F I +AV +C + HRDLK EN+LL + KL DFG Sbjct: 114 YLTSNGHLSENEARKKFWQILSAV--EYCHNHHIVHRDLKTENLLLDGNMDIKLADFGFG 171 Query: 1224 STNHKCFDKPEERGIEEDIIRKHTTPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICY 1403 + F KP E + +P Y APE+++ +E ++DIW+LG ++Y + Sbjct: 172 N-----FYKP-----GEPLSTWCGSPPYAAPEVFE--GKEYEGPQLDIWSLGVVLYVLVC 219 Query: 1404 LKSAFDGES----KLQILNGNYRIPELPKYCSSITSLIEEMLQSSPDARPDITQV----W 1559 FDG + + ++L G +RIP +LI ML P R I Q+ W Sbjct: 220 GSLPFDGPNLPTLRQRVLEGRFRIPFF--MSQDCETLIRRMLVVDPAKRITIAQIRQHRW 277 Query: 1560 FRVNELLPLELQKDLPDGSPSG 1625 + + P LQ+D P S G Sbjct: 278 MQAD---PTLLQQDDPAFSMQG 296
>Q62829:PAK3_RAT Serine/threonine-protein kinase PAK 3 - Rattus norvegicus (Rat)| Length = 544 Score = 80.5 bits (197), Expect = 4e-14 Identities = 70/259 (27%), Positives = 119/259 (45%), Gaps = 5/259 (1%) Frame = +3 Query: 777 EAIAEGGFSCVYLARDLTNPAKHYALKHVIVQDKESLDLVHKEITVMRALKGHPNVVTLV 956 E I +G VY A D+ + A+K + +Q + +L+ EI VMR K +PN+V + Sbjct: 272 EKIGQGASGTVYTALDIAT-GQEVAIKQMNLQQQPKKELIINEILVMRENK-NPNIVNYL 329 Query: 957 AHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAMHCQT 1136 ++ G E ++ME+ ++ + T D+ Q+A + R+ A+ +H Sbjct: 330 DSYLV----GDELWVVMEYLAGGSLTDVV---TETCMDEGQIAAVCRECLQALDFLHSNQ 382 Query: 1137 PPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHTTPAYRAP 1316 V HRD+K++N+LLG DG+ KL DFG C E+ ++ TP + AP Sbjct: 383 --VIHRDIKSDNILLGMDGSVKLTDFGF------CAQITPEQSKRSTMV---GTPYWMAP 431 Query: 1317 EMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQIL-----NGNYRIPELPKY 1481 E + R+ KVDIW+LG + + + + E+ L+ L NG + + Sbjct: 432 E---VVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERL 488 Query: 1482 CSSITSLIEEMLQSSPDAR 1538 + + L+ D R Sbjct: 489 SAVFRDFLNRCLEMDVDRR 507
>Q7YQL3:PAK3_PONPY Serine/threonine-protein kinase PAK 3 - Pongo pygmaeus (Orangutan)| Length = 559 Score = 80.5 bits (197), Expect = 4e-14 Identities = 70/259 (27%), Positives = 119/259 (45%), Gaps = 5/259 (1%) Frame = +3 Query: 777 EAIAEGGFSCVYLARDLTNPAKHYALKHVIVQDKESLDLVHKEITVMRALKGHPNVVTLV 956 E I +G VY A D+ + A+K + +Q + +L+ EI VMR K +PN+V + Sbjct: 287 EKIGQGASGTVYTALDIAT-GQEVAIKQMNLQQQPKKELIINEILVMRENK-NPNIVNYL 344 Query: 957 AHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAMHCQT 1136 ++ G E ++ME+ ++ + T D+ Q+A + R+ A+ +H Sbjct: 345 DSYLV----GDELWVVMEYLAGGSLTDVV---TETCMDEGQIAAVCRECLQALDFLHSNQ 397 Query: 1137 PPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHTTPAYRAP 1316 V HRD+K++N+LLG DG+ KL DFG C E+ ++ TP + AP Sbjct: 398 --VIHRDIKSDNILLGMDGSVKLTDFGF------CAQITPEQSKRSTMV---GTPYWMAP 446 Query: 1317 EMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQIL-----NGNYRIPELPKY 1481 E + R+ KVDIW+LG + + + + E+ L+ L NG + + Sbjct: 447 E---VVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERL 503 Query: 1482 CSSITSLIEEMLQSSPDAR 1538 + + L+ D R Sbjct: 504 SAVFRDFLNRCLEMDVDRR 522
>Q7YQL4:PAK3_PANTR Serine/threonine-protein kinase PAK 3 - Pan troglodytes (Chimpanzee)| Length = 559 Score = 80.5 bits (197), Expect = 4e-14 Identities = 70/259 (27%), Positives = 119/259 (45%), Gaps = 5/259 (1%) Frame = +3 Query: 777 EAIAEGGFSCVYLARDLTNPAKHYALKHVIVQDKESLDLVHKEITVMRALKGHPNVVTLV 956 E I +G VY A D+ + A+K + +Q + +L+ EI VMR K +PN+V + Sbjct: 287 EKIGQGASGTVYTALDIAT-GQEVAIKQMNLQQQPKKELIINEILVMRENK-NPNIVNYL 344 Query: 957 AHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAMHCQT 1136 ++ G E ++ME+ ++ + T D+ Q+A + R+ A+ +H Sbjct: 345 DSYLV----GDELWVVMEYLAGGSLTDVV---TETCMDEGQIAAVCRECLQALDFLHSNQ 397 Query: 1137 PPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHTTPAYRAP 1316 V HRD+K++N+LLG DG+ KL DFG C E+ ++ TP + AP Sbjct: 398 --VIHRDIKSDNILLGMDGSVKLTDFGF------CAQITPEQSKRSTMV---GTPYWMAP 446 Query: 1317 EMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQIL-----NGNYRIPELPKY 1481 E + R+ KVDIW+LG + + + + E+ L+ L NG + + Sbjct: 447 E---VVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERL 503 Query: 1482 CSSITSLIEEMLQSSPDAR 1538 + + L+ D R Sbjct: 504 SAVFRDFLNRCLEMDVDRR 522
>Q61036:PAK3_MOUSE Serine/threonine-protein kinase PAK 3 - Mus musculus (Mouse)| Length = 559 Score = 80.5 bits (197), Expect = 4e-14 Identities = 70/259 (27%), Positives = 119/259 (45%), Gaps = 5/259 (1%) Frame = +3 Query: 777 EAIAEGGFSCVYLARDLTNPAKHYALKHVIVQDKESLDLVHKEITVMRALKGHPNVVTLV 956 E I +G VY A D+ + A+K + +Q + +L+ EI VMR K +PN+V + Sbjct: 287 EKIGQGASGTVYTALDIAT-GQEVAIKQMNLQQQPKKELIINEILVMRENK-NPNIVNYL 344 Query: 957 AHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAMHCQT 1136 ++ G E ++ME+ ++ + T D+ Q+A + R+ A+ +H Sbjct: 345 DSYLV----GDELWVVMEYLAGGSLTDVV---TETCMDEGQIAAVCRECLQALDFLHSNQ 397 Query: 1137 PPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHTTPAYRAP 1316 V HRD+K++N+LLG DG+ KL DFG C E+ ++ TP + AP Sbjct: 398 --VIHRDIKSDNILLGMDGSVKLTDFGF------CAQITPEQSKRSTMV---GTPYWMAP 446 Query: 1317 EMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQIL-----NGNYRIPELPKY 1481 E + R+ KVDIW+LG + + + + E+ L+ L NG + + Sbjct: 447 E---VVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERL 503 Query: 1482 CSSITSLIEEMLQSSPDAR 1538 + + L+ D R Sbjct: 504 SAVFRDFLNRCLEMDVDRR 522
>O75914:PAK3_HUMAN Serine/threonine-protein kinase PAK 3 - Homo sapiens (Human)| Length = 559 Score = 80.5 bits (197), Expect = 4e-14 Identities = 70/259 (27%), Positives = 119/259 (45%), Gaps = 5/259 (1%) Frame = +3 Query: 777 EAIAEGGFSCVYLARDLTNPAKHYALKHVIVQDKESLDLVHKEITVMRALKGHPNVVTLV 956 E I +G VY A D+ + A+K + +Q + +L+ EI VMR K +PN+V + Sbjct: 287 EKIGQGASGTVYTALDIAT-GQEVAIKQMNLQQQPKKELIINEILVMRENK-NPNIVNYL 344 Query: 957 AHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAMHCQT 1136 ++ G E ++ME+ ++ + T D+ Q+A + R+ A+ +H Sbjct: 345 DSYLV----GDELWVVMEYLAGGSLTDVV---TETCMDEGQIAAVCRECLQALDFLHSNQ 397 Query: 1137 PPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHTTPAYRAP 1316 V HRD+K++N+LLG DG+ KL DFG C E+ ++ TP + AP Sbjct: 398 --VIHRDIKSDNILLGMDGSVKLTDFGF------CAQITPEQSKRSTMV---GTPYWMAP 446 Query: 1317 EMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQIL-----NGNYRIPELPKY 1481 E + R+ KVDIW+LG + + + + E+ L+ L NG + + Sbjct: 447 E---VVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERL 503 Query: 1482 CSSITSLIEEMLQSSPDAR 1538 + + L+ D R Sbjct: 504 SAVFRDFLNRCLEMDVDRR 522
>Q5R7G9:NUAK2_PONPY NUAK family SNF1-like kinase 2 - Pongo pygmaeus (Orangutan)| Length = 628 Score = 80.5 bits (197), Expect = 4e-14 Identities = 73/267 (27%), Positives = 122/267 (45%), Gaps = 7/267 (2%) Frame = +3 Query: 777 EAIAEGGFSCVYLARDLTNPAKHYALKHVI---VQDKESLDLVHKEITVMRALKGHPNVV 947 E + +G + V AR+ + + A+K + ++D++ L + +EI +M +L HP+++ Sbjct: 57 ETLGKGTYGKVKKARE--SSGRLVAIKSIRKDKIKDEQDLMHIRREIEIMSSLN-HPHII 113 Query: 948 TLVAHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAMH 1127 + H + + + +++ME+ R D + + FR I +AV + Sbjct: 114 AI--HEVFE--NSSKIVIVMEYASRG--DLYDYISERQQLSEREARHFFRQIVSAVH--Y 165 Query: 1128 CQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHTTPAY 1307 C V HRDLK EN+LL A+G K+ DFG + H+ G +P Y Sbjct: 166 CHQNRVVHRDLKLENILLDANGNIKIADFGLSNLYHQGKFLQTFCG----------SPLY 215 Query: 1308 RAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESK----LQILNGNYRIPELP 1475 +PE+ + + +VD W+LG L+Y + + FDG QI NG YR P P Sbjct: 216 ASPEI--VNGKPYTGPEVDSWSLGVLLYILVHGTMPFDGHDHKILVKQISNGAYREPPKP 273 Query: 1476 KYCSSITSLIEEMLQSSPDARPDITQV 1556 S LI +L +P R + V Sbjct: 274 ---SDACGLIRWLLMVNPTRRATLEDV 297
>Q9H093:NUAK2_HUMAN NUAK family SNF1-like kinase 2 - Homo sapiens (Human)| Length = 628 Score = 80.5 bits (197), Expect = 4e-14 Identities = 73/267 (27%), Positives = 122/267 (45%), Gaps = 7/267 (2%) Frame = +3 Query: 777 EAIAEGGFSCVYLARDLTNPAKHYALKHVI---VQDKESLDLVHKEITVMRALKGHPNVV 947 E + +G + V AR+ + + A+K + ++D++ L + +EI +M +L HP+++ Sbjct: 57 ETLGKGTYGKVKKARE--SSGRLVAIKSIRKDKIKDEQDLMHIRREIEIMSSLN-HPHII 113 Query: 948 TLVAHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAMH 1127 + H + + + +++ME+ R D + + FR I +AV + Sbjct: 114 AI--HEVFE--NSSKIVIVMEYASRG--DLYDYISERQQLSEREARHFFRQIVSAVH--Y 165 Query: 1128 CQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHTTPAY 1307 C V HRDLK EN+LL A+G K+ DFG + H+ G +P Y Sbjct: 166 CHQNRVVHRDLKLENILLDANGNIKIADFGLSNLYHQGKFLQTFCG----------SPLY 215 Query: 1308 RAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESK----LQILNGNYRIPELP 1475 +PE+ + + +VD W+LG L+Y + + FDG QI NG YR P P Sbjct: 216 ASPEI--VNGKPYTGPEVDSWSLGVLLYILVHGTMPFDGHDHKILVKQISNGAYREPPKP 273 Query: 1476 KYCSSITSLIEEMLQSSPDARPDITQV 1556 S LI +L +P R + V Sbjct: 274 ---SDACGLIRWLLMVNPTRRATLEDV 297
>P35465:PAK1_RAT Serine/threonine-protein kinase PAK 1 - Rattus norvegicus (Rat)| Length = 544 Score = 80.1 bits (196), Expect = 5e-14 Identities = 70/259 (27%), Positives = 119/259 (45%), Gaps = 5/259 (1%) Frame = +3 Query: 777 EAIAEGGFSCVYLARDLTNPAKHYALKHVIVQDKESLDLVHKEITVMRALKGHPNVVTLV 956 E I +G VY A D+ + A+K + +Q + +L+ EI VMR K +PN+V + Sbjct: 273 EKIGQGASGTVYTAMDVAT-GQEVAIKQMNLQQQPKKELIINEILVMRENK-NPNIVNYL 330 Query: 957 AHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAMHCQT 1136 ++ G E ++ME+ ++ + T D+ Q+A + R+ A+ +H Sbjct: 331 DSYLV----GDELWVVMEYLAGGSLTDVV---TETCMDEGQIAAVCRECLQALEFLHSNQ 383 Query: 1137 PPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHTTPAYRAP 1316 V HRD+K++N+LLG DG+ KL DFG C E+ ++ TP + AP Sbjct: 384 --VIHRDIKSDNILLGMDGSVKLTDFGF------CAQITPEQSKRSTMV---GTPYWMAP 432 Query: 1317 EMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQIL-----NGNYRIPELPKY 1481 E + R+ KVDIW+LG + + + + E+ L+ L NG + K Sbjct: 433 E---VVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKL 489 Query: 1482 CSSITSLIEEMLQSSPDAR 1538 + + L+ + R Sbjct: 490 SAIFRDFLNRCLEMDVEKR 508
>Q13153:PAK1_HUMAN Serine/threonine-protein kinase PAK 1 - Homo sapiens (Human)| Length = 545 Score = 80.1 bits (196), Expect = 5e-14 Identities = 70/259 (27%), Positives = 119/259 (45%), Gaps = 5/259 (1%) Frame = +3 Query: 777 EAIAEGGFSCVYLARDLTNPAKHYALKHVIVQDKESLDLVHKEITVMRALKGHPNVVTLV 956 E I +G VY A D+ + A+K + +Q + +L+ EI VMR K +PN+V + Sbjct: 274 EKIGQGASGTVYTAMDVAT-GQEVAIKQMNLQQQPKKELIINEILVMRENK-NPNIVNYL 331 Query: 957 AHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAMHCQT 1136 ++ G E ++ME+ ++ + T D+ Q+A + R+ A+ +H Sbjct: 332 DSYLV----GDELWVVMEYLAGGSLTDVV---TETCMDEGQIAAVCRECLQALEFLHSNQ 384 Query: 1137 PPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHTTPAYRAP 1316 V HRD+K++N+LLG DG+ KL DFG C E+ ++ TP + AP Sbjct: 385 --VIHRDIKSDNILLGMDGSVKLTDFGF------CAQITPEQSKRSTMV---GTPYWMAP 433 Query: 1317 EMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQIL-----NGNYRIPELPKY 1481 E + R+ KVDIW+LG + + + + E+ L+ L NG + K Sbjct: 434 E---VVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKL 490 Query: 1482 CSSITSLIEEMLQSSPDAR 1538 + + L+ + R Sbjct: 491 SAIFRDFLNRCLEMDVEKR 509
>Q08E52:PAK1_BOVIN Serine/threonine-protein kinase PAK 1 - Bos taurus (Bovine)| Length = 544 Score = 80.1 bits (196), Expect = 5e-14 Identities = 70/259 (27%), Positives = 119/259 (45%), Gaps = 5/259 (1%) Frame = +3 Query: 777 EAIAEGGFSCVYLARDLTNPAKHYALKHVIVQDKESLDLVHKEITVMRALKGHPNVVTLV 956 E I +G VY A D+ + A+K + +Q + +L+ EI VMR K +PN+V + Sbjct: 273 EKIGQGASGTVYTAMDVAT-GQEVAIKQMNLQQQPKKELIINEILVMRENK-NPNIVNYL 330 Query: 957 AHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAMHCQT 1136 ++ G E ++ME+ ++ + T D+ Q+A + R+ A+ +H Sbjct: 331 DSYLV----GDELWVVMEYLAGGSLTDVV---TETCMDEGQIAAVCRECLQALEFLHSNQ 383 Query: 1137 PPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHTTPAYRAP 1316 V HRD+K++N+LLG DG+ KL DFG C E+ ++ TP + AP Sbjct: 384 --VIHRDIKSDNILLGMDGSVKLTDFGF------CAQITPEQSKRSTMV---GTPYWMAP 432 Query: 1317 EMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQIL-----NGNYRIPELPKY 1481 E + R+ KVDIW+LG + + + + E+ L+ L NG + K Sbjct: 433 E---VVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKL 489 Query: 1482 CSSITSLIEEMLQSSPDAR 1538 + + L+ + R Sbjct: 490 SAIFRDFLNRCLEMDVEKR 508
>Q64303:PAK2_RAT Serine/threonine-protein kinase PAK 2 - Rattus norvegicus (Rat)| Length = 524 Score = 79.7 bits (195), Expect = 7e-14 Identities = 64/223 (28%), Positives = 110/223 (49%) Frame = +3 Query: 777 EAIAEGGFSCVYLARDLTNPAKHYALKHVIVQDKESLDLVHKEITVMRALKGHPNVVTLV 956 E I +G V+ A D+ + A+K + +Q + +L+ EI VM+ LK +PN+V + Sbjct: 253 EKIGQGASGTVFTATDVAL-GQEVAIKQINLQKQPKKELIINEILVMKELK-NPNIVNFL 310 Query: 957 AHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAMHCQT 1136 ++ G E ++ME+ ++ + T D+ Q+A + R+ A+ +H Sbjct: 311 DSYLV----GDELFVVMEYLAGGSLTDVV---TETCMDEAQIAAVCRECLQALEFLHANQ 363 Query: 1137 PPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHTTPAYRAP 1316 V HRD+K++NVLLG +G+ KL DFG C E+ ++ TP + AP Sbjct: 364 --VIHRDIKSDNVLLGMEGSVKLTDFGF------CAQITPEQSKRSTMV---GTPYWMAP 412 Query: 1317 EMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQIL 1445 E + R+ KVDIW+LG + + + + E+ L+ L Sbjct: 413 E---VVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRAL 452
>Q29502:PAK2_RABIT Serine/threonine-protein kinase PAK 2 - Oryctolagus cuniculus| (Rabbit) Length = 524 Score = 79.7 bits (195), Expect = 7e-14 Identities = 64/223 (28%), Positives = 110/223 (49%) Frame = +3 Query: 777 EAIAEGGFSCVYLARDLTNPAKHYALKHVIVQDKESLDLVHKEITVMRALKGHPNVVTLV 956 E I +G V+ A D+ + A+K + +Q + +L+ EI VM+ LK +PN+V + Sbjct: 253 EKIGQGASGTVFTATDVAL-GQEVAIKQINLQKQPKKELIINEILVMKELK-NPNIVNFL 310 Query: 957 AHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAMHCQT 1136 ++ G E ++ME+ ++ + T D+ Q+A + R+ A+ +H Sbjct: 311 DSYLV----GDELFVVMEYLAGGSLTDVV---TETCMDEAQIAAVCRECLQALEFLHANQ 363 Query: 1137 PPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHTTPAYRAP 1316 V HRD+K++NVLLG +G+ KL DFG C E+ ++ TP + AP Sbjct: 364 --VIHRDIKSDNVLLGMEGSVKLTDFGF------CAQITPEQSKRSTMV---GTPYWMAP 412 Query: 1317 EMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQIL 1445 E + R+ KVDIW+LG + + + + E+ L+ L Sbjct: 413 E---VVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRAL 452
>Q8CIN4:PAK2_MOUSE Serine/threonine-protein kinase PAK 2 - Mus musculus (Mouse)| Length = 524 Score = 79.7 bits (195), Expect = 7e-14 Identities = 64/223 (28%), Positives = 110/223 (49%) Frame = +3 Query: 777 EAIAEGGFSCVYLARDLTNPAKHYALKHVIVQDKESLDLVHKEITVMRALKGHPNVVTLV 956 E I +G V+ A D+ + A+K + +Q + +L+ EI VM+ LK +PN+V + Sbjct: 253 EKIGQGASGTVFTATDVAL-GQEVAIKQINLQKQPKKELIINEILVMKELK-NPNIVNFL 310 Query: 957 AHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAMHCQT 1136 ++ G E ++ME+ ++ + T D+ Q+A + R+ A+ +H Sbjct: 311 DSYLV----GDELFVVMEYLAGGSLTDVV---TETCMDEAQIAAVCRECLQALEFLHANQ 363 Query: 1137 PPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHTTPAYRAP 1316 V HRD+K++NVLLG +G+ KL DFG C E+ ++ TP + AP Sbjct: 364 --VIHRDIKSDNVLLGMEGSVKLTDFGF------CAQITPEQSKRSTMV---GTPYWMAP 412 Query: 1317 EMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQIL 1445 E + R+ KVDIW+LG + + + + E+ L+ L Sbjct: 413 E---VVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRAL 452
>Q13177:PAK2_HUMAN Serine/threonine-protein kinase PAK 2 - Homo sapiens (Human)| Length = 524 Score = 79.7 bits (195), Expect = 7e-14 Identities = 64/223 (28%), Positives = 110/223 (49%) Frame = +3 Query: 777 EAIAEGGFSCVYLARDLTNPAKHYALKHVIVQDKESLDLVHKEITVMRALKGHPNVVTLV 956 E I +G V+ A D+ + A+K + +Q + +L+ EI VM+ LK +PN+V + Sbjct: 253 EKIGQGASGTVFTATDVAL-GQEVAIKQINLQKQPKKELIINEILVMKELK-NPNIVNFL 310 Query: 957 AHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAMHCQT 1136 ++ G E ++ME+ ++ + T D+ Q+A + R+ A+ +H Sbjct: 311 DSYLV----GDELFVVMEYLAGGSLTDVV---TETCMDEAQIAAVCRECLQALEFLHANQ 363 Query: 1137 PPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHTTPAYRAP 1316 V HRD+K++NVLLG +G+ KL DFG C E+ ++ TP + AP Sbjct: 364 --VIHRDIKSDNVLLGMEGSVKLTDFGF------CAQITPEQSKRSTMV---GTPYWMAP 412 Query: 1317 EMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQIL 1445 E + R+ KVDIW+LG + + + + E+ L+ L Sbjct: 413 E---VVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRAL 452
>O88643:PAK1_MOUSE Serine/threonine-protein kinase PAK 1 - Mus musculus (Mouse)| Length = 545 Score = 79.7 bits (195), Expect = 7e-14 Identities = 65/223 (29%), Positives = 109/223 (48%) Frame = +3 Query: 777 EAIAEGGFSCVYLARDLTNPAKHYALKHVIVQDKESLDLVHKEITVMRALKGHPNVVTLV 956 E I +G VY A D+ + A+K + +Q + +L+ EI VMR K +PN+V + Sbjct: 274 EKIGQGASGTVYTAMDVAT-GQEVAIKQMNLQQQPKKELIINEILVMRENK-NPNIVNYL 331 Query: 957 AHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAMHCQT 1136 ++ G E ++ME+ ++ + T D+ Q+A + R+ A+ +H Sbjct: 332 DSYLV----GDELWVVMEYLAGGSLTDVV---TETCMDEGQIAAVCRECLQALEFLHSNQ 384 Query: 1137 PPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHTTPAYRAP 1316 V HRD+K++N+LLG DG+ KL DFG C E+ ++ TP + AP Sbjct: 385 --VIHRDIKSDNILLGMDGSVKLTDFGF------CAQITPEQSKRSTMV---GTPYWMAP 433 Query: 1317 EMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQIL 1445 E + R+ KVDIW+LG + + + + E+ L+ L Sbjct: 434 E---VVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRAL 473
>Q9R0A5:NEK3_MOUSE Serine/threonine-protein kinase Nek3 - Mus musculus (Mouse)| Length = 511 Score = 79.3 bits (194), Expect = 9e-14 Identities = 79/287 (27%), Positives = 128/287 (44%), Gaps = 8/287 (2%) Frame = +3 Query: 771 VREAIAEGGFSCVYLARDLTNPAKHYALKHVIVQDKESLDLVHKEITVMRALKGHPNVVT 950 V I +G F L ++ + +A+K + + K KE ++ +K HPN+V Sbjct: 6 VLRVIGQGSFGRALLVLQESSN-QTFAMKEIRLL-KSDTQTSRKEAVLLAKMK-HPNIVA 62 Query: 951 LVAHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAMHC 1130 + ++ME+C+ + + + ++ + F IC V +H Sbjct: 63 FKESFEAE----GYLYIVMEYCDGGDLMQRIKQQKGNLFPEDTILNWFIQICLGVNHIHK 118 Query: 1131 QTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHT---TP 1301 + V HRD+K++NV L +G KL DFGS R + + T TP Sbjct: 119 RR--VLHRDIKSKNVFLTHNGKVKLGDFGSA------------RLLSSPMAFACTYVGTP 164 Query: 1302 AYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGES----KLQILNGN-YRIP 1466 Y PE+W+ + K DIW+LGC++Y +C LK F S L+I G + +P Sbjct: 165 YYVPPEIWE---NLPYNNKSDIWSLGCILYELCALKHPFQANSWKNLILKICQGPIHPLP 221 Query: 1467 ELPKYCSSITSLIEEMLQSSPDARPDITQVWFRVNELLPLELQKDLP 1607 L Y + L+++ML+ +P RP T + R L PL + K LP Sbjct: 222 AL--YSCKLQGLVKQMLKRNPSHRPSATTLLCR-GSLAPL-VPKCLP 264
>P57059:SN1L1_HUMAN Serine/threonine-protein kinase SNF1-like kinase 1 - Homo sapiens| (Human) Length = 783 Score = 79.0 bits (193), Expect = 1e-13 Identities = 80/308 (25%), Positives = 141/308 (45%), Gaps = 11/308 (3%) Frame = +3 Query: 693 LMPKEHSGPSGGLEGRTIDVGNVKVHVREAIAEGGFSCVYLARDLTNPAKHYALKHVIVQ 872 +M + + P+G +G+ + + + +G F+ V LAR + A+K + Sbjct: 3 IMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQ-VAIKIIDKT 61 Query: 873 --DKESLDLVHKEITVMRALKGHPNVVTLVAHTILDMGRGREALLLM-EFCERSLVSALD 1043 D +L+ +++E+ +M+ L HP+++ L + +++ ++ L ++ EF + D Sbjct: 62 RLDSSNLEKIYREVQLMKLLN-HPHIIKL--YQVMET---KDMLYIVTEFAKNG--EMFD 113 Query: 1044 ARGTAGFYDDEQVALIFRDICNAVFAMHCQTPPVAHRDLKAENVLLGADGAWKLCDFGSV 1223 + G + + F I +AV +C + HRDLK EN+LL + KL DFG Sbjct: 114 YLTSNGHLSENEARKKFWQILSAV--EYCHDHHIVHRDLKTENLLLDGNMDIKLADFG-- 169 Query: 1224 STNHKCFDKPEERGIEEDIIRKHTTPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICY 1403 F + G E + +P Y APE+++ +E ++DIW+LG ++Y + Sbjct: 170 ------FGNFYKSG--EPLSTWCGSPPYAAPEVFE--GKEYEGPQLDIWSLGVVLYVLVC 219 Query: 1404 LKSAFDGES----KLQILNGNYRIPELPKYCSSITSLIEEMLQSSPDARPDITQV----W 1559 FDG + + ++L G +RIP SLI ML P R I Q+ W Sbjct: 220 GSLPFDGPNLPTLRQRVLEGRFRIPFF--MSQDCESLIRRMLVVDPARRITIAQIRQHRW 277 Query: 1560 FRVNELLP 1583 R LP Sbjct: 278 MRAEPCLP 285
>P43637:KGS9_YEAST Probable serine/threonine-protein kinase YGL179C - Saccharomyces| cerevisiae (Baker's yeast) Length = 560 Score = 79.0 bits (193), Expect = 1e-13 Identities = 82/293 (27%), Positives = 133/293 (45%), Gaps = 35/293 (11%) Frame = +3 Query: 783 IAEGGFSCVYLARDLTNPAKHYALKHVIVQDKES---LDL------VHKEITVMRALKGH 935 + G + V LARDL A A+K + +K S L L V++EI VM+ H Sbjct: 56 LGNGQYGKVKLARDLGTGAL-VAIKILNRFEKRSGYSLQLKVENPRVNQEIEVMKRCH-H 113 Query: 936 PNVVTLVAHTILDMGRGREALLLMEFCERSLVS-------ALDARGTAGFYDDEQVALIF 1094 NVV L + IL+ + L++E+C R V + A G + +Q + Sbjct: 114 ENVVEL--YEILNDPESTKVYLVLEYCSRGPVKWCPENKMEIKAVGPS-ILTFQQSRKVV 170 Query: 1095 RDICNAVFAMHCQTPPVAHRDLKAENVLLGADGAWKLCDFG---SVSTNHKCFDKPEERG 1265 D+ + + +H Q + HRD+K N+L+ ++G K+ DFG S +T E+ Sbjct: 171 LDVVSGLEYLHSQG--ITHRDIKPSNLLISSNGTVKISDFGVAMSTATGSTNIQSSHEQL 228 Query: 1266 IEEDIIRKHTTPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQIL 1445 ++ R TPA+ APE+ + S +DIW+LG +Y + + K F+ S L++ Sbjct: 229 LKS---RALGTPAFFAPELCSTEKEYSCSSAIDIWSLGVTIYCLLFGKLPFNANSGLELF 285 Query: 1446 NGNYRIP-ELPKY-------CSSIT--------SLIEEMLQSSPDARPDITQV 1556 + P E P Y S IT L++++LQ PD R + + Sbjct: 286 DSIINKPLEFPSYEEMLNGATSGITMEEYTDAKDLLKKLLQKDPDKRIKLADI 338
>Q5E9Y0:CDK2_BOVIN Cell division protein kinase 2 - Bos taurus (Bovine)| Length = 298 Score = 79.0 bits (193), Expect = 1e-13 Identities = 77/267 (28%), Positives = 121/267 (45%), Gaps = 4/267 (1%) Frame = +3 Query: 777 EAIAEGGFSCVYLARDLTNPAKHYALKHVIVQDKES--LDLVHKEITVMRALKGHPNVVT 950 E I EG + VY A++ + ALK + + + +EI++++ L HPN+V Sbjct: 8 EKIGEGTYGVVYKAKNKLT-GEVVALKKIRLDTETEGVPSTAIREISLLKELN-HPNIVK 65 Query: 951 L--VAHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAM 1124 L V HT + L+ EF + L +DA G + +F+ + F Sbjct: 66 LLDVIHT------ENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAF-- 117 Query: 1125 HCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHTTPA 1304 C + V HRDLK +N+L+ ADG+ KL DFG + F P E + T Sbjct: 118 -CHSHRVLHRDLKPQNLLINADGSIKLADFGLA----RAFGVPVRTYTHEVV-----TLW 167 Query: 1305 YRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQILNGNYRIPELPKYC 1484 YRAPE+ L + S VDIW+LGC+ + ++ F G+S++ L +R P Sbjct: 168 YRAPEI--LLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTP--- 222 Query: 1485 SSITSLIEEMLQSSPDARPDITQVWFR 1565 ++ + S PD +P + W R Sbjct: 223 ---DEVVWPGVTSMPDYKPSFPK-WAR 245
>Q66HE5:NUAK2_RAT NUAK family SNF1-like kinase 2 - Rattus norvegicus (Rat)| Length = 630 Score = 78.6 bits (192), Expect = 1e-13 Identities = 78/297 (26%), Positives = 134/297 (45%), Gaps = 12/297 (4%) Frame = +3 Query: 777 EAIAEGGFSCVYLARDLTNPAKHYALKHVI---VQDKESLDLVHKEITVMRALKGHPNVV 947 E + +G + V AR+ + + A+K + ++D++ L + +EI +M +L HP+++ Sbjct: 61 ETLGKGTYGKVKKARE--SSGRLVAIKSIRKDKIKDEQDLLHIRREIEIMSSLN-HPHII 117 Query: 948 TLVAHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAMH 1127 + H + + + +++ME+ R D ++ FR I +A+ + Sbjct: 118 AI--HEVFE--NSSKIVIVMEYASRG--DLYDYISERPRLNERDARHFFRQIVSALH--Y 169 Query: 1128 CQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHTTPAY 1307 C + HRDLK EN+LL A G K+ DFG + HK G +P Y Sbjct: 170 CHQNGIVHRDLKLENILLDASGNIKIADFGLSNLYHKGKFLQTFCG----------SPLY 219 Query: 1308 RAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESK----LQILNGNYRIPELP 1475 +PE+ + + + +VD W+LG L+Y + + FDG+ QI +G YR P P Sbjct: 220 ASPEI--VNGKPYVGPEVDSWSLGVLLYILVHGTMPFDGQDHKTLVKQISSGAYREPCKP 277 Query: 1476 KYCSSITSLIEEMLQSSPDARPDITQV----WFRVNELLPLELQKDLPDGS-PSGSA 1631 S LI +L +P R + V W + Q+ L +G PSG + Sbjct: 278 ---SDACGLIRWLLMVNPIRRATLEDVASHWWVNWGYSTRIGEQEALREGGHPSGDS 331
>Q5R8Z4:PAK6_PONPY Serine/threonine-protein kinase PAK 6 - Pongo pygmaeus (Orangutan)| Length = 681 Score = 78.2 bits (191), Expect = 2e-13 Identities = 77/284 (27%), Positives = 135/284 (47%), Gaps = 8/284 (2%) Frame = +3 Query: 783 IAEGGFSCVYLARDLTNPAKHYALKHVIVQDKESLDLVHKEITVMRALKGHPNVVTLVAH 962 I EG V LAR+ + + A+K + ++ ++ +L+ E+ +MR + H NVV + Sbjct: 413 IGEGSTGIVCLARE-KHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQ-HFNVVEMYKS 470 Query: 963 TILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAMHCQTPP 1142 ++ G E +LMEF + ++ + ++ ++EQ+A + + A+ +H Q Sbjct: 471 YLV----GEELWVLMEFLQGGALTDIVSQVRL---NEEQIATVCEAVLQALAYLHAQG-- 521 Query: 1143 VAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHTTPAYRAPEM 1322 V HRD+K++++LL DG KL DFG + K D P+ + + TP + APE Sbjct: 522 VIHRDIKSDSILLTLDGRVKLSDFGFCAQISK--DVPKRKSLV-------GTPYWMAPE- 571 Query: 1323 WDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQILNGNYRIPELPKYCSS---- 1490 + R + + +VDIW+LG ++ + + + +S +Q + R PK +S Sbjct: 572 --VISRSLYATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMK-RLRDSPPPKLKNSHKVS 628 Query: 1491 --ITSLIEEMLQSSPDARPDITQVWFRVNELL--PLELQKDLPD 1610 + +E ML P R ELL P LQ LP+ Sbjct: 629 PVLRDFLERMLVRDPQERA-------TAQELLDHPFLLQTGLPE 665
>Q9NQU5:PAK6_HUMAN Serine/threonine-protein kinase PAK 6 - Homo sapiens (Human)| Length = 681 Score = 78.2 bits (191), Expect = 2e-13 Identities = 77/284 (27%), Positives = 135/284 (47%), Gaps = 8/284 (2%) Frame = +3 Query: 783 IAEGGFSCVYLARDLTNPAKHYALKHVIVQDKESLDLVHKEITVMRALKGHPNVVTLVAH 962 I EG V LAR+ + + A+K + ++ ++ +L+ E+ +MR + H NVV + Sbjct: 413 IGEGSTGIVCLARE-KHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQ-HFNVVEMYKS 470 Query: 963 TILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAMHCQTPP 1142 ++ G E +LMEF + ++ + ++ ++EQ+A + + A+ +H Q Sbjct: 471 YLV----GEELWVLMEFLQGGALTDIVSQVRL---NEEQIATVCEAVLQALAYLHAQG-- 521 Query: 1143 VAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHTTPAYRAPEM 1322 V HRD+K++++LL DG KL DFG + K D P+ + + TP + APE Sbjct: 522 VIHRDIKSDSILLTLDGRVKLSDFGFCAQISK--DVPKRKSLV-------GTPYWMAPE- 571 Query: 1323 WDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQILNGNYRIPELPKYCSS---- 1490 + R + + +VDIW+LG ++ + + + +S +Q + R PK +S Sbjct: 572 --VISRSLYATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMK-RLRDSPPPKLKNSHKVS 628 Query: 1491 --ITSLIEEMLQSSPDARPDITQVWFRVNELL--PLELQKDLPD 1610 + +E ML P R ELL P LQ LP+ Sbjct: 629 PVLRDFLERMLVRDPQERA-------TAQELLDHPFLLQTGLPE 665
>P23437:CDK2_XENLA Cell division protein kinase 2 - Xenopus laevis (African clawed frog)| Length = 297 Score = 78.2 bits (191), Expect = 2e-13 Identities = 69/227 (30%), Positives = 107/227 (47%), Gaps = 4/227 (1%) Frame = +3 Query: 777 EAIAEGGFSCVYLARDLTNPAKHYALKHVIVQDKES--LDLVHKEITVMRALKGHPNVVT 950 E I EG + VY AR+ + ALK + + + +EI++++ L HPN+V Sbjct: 8 EKIGEGTYGVVYKARN-RETGEIVALKKIRLDTETEGVPSTAIREISLLKELN-HPNIVK 65 Query: 951 L--VAHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAM 1124 L V HT + L+ EF + L +D +G + +F+ + F Sbjct: 66 LLDVIHT------ENKLYLVFEFLNQDLKKFMDGSNISGISLALVKSYLFQLLQGLAF-- 117 Query: 1125 HCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHTTPA 1304 C + V HRDLK +N+L+ +DGA KL DFG + F P E + T Sbjct: 118 -CHSHRVLHRDLKPQNLLINSDGAIKLADFGLA----RAFGVPVRTFTHEVV-----TLW 167 Query: 1305 YRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQIL 1445 YRAPE+ L + S VDIW+LGC+ + ++ F G+S++ L Sbjct: 168 YRAPEI--LLGCKFYSTAVDIWSLGCIFAEMITRRALFPGDSEIDQL 212
>P24941:CDK2_HUMAN Cell division protein kinase 2 - Homo sapiens (Human)| Length = 298 Score = 78.2 bits (191), Expect = 2e-13 Identities = 77/267 (28%), Positives = 120/267 (44%), Gaps = 4/267 (1%) Frame = +3 Query: 777 EAIAEGGFSCVYLARDLTNPAKHYALKHVIVQDKES--LDLVHKEITVMRALKGHPNVVT 950 E I EG + VY AR+ + ALK + + + +EI++++ L HPN+V Sbjct: 8 EKIGEGTYGVVYKARNKLT-GEVVALKKIRLDTETEGVPSTAIREISLLKELN-HPNIVK 65 Query: 951 L--VAHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAM 1124 L V HT + L+ EF + L +DA G + +F+ + F Sbjct: 66 LLDVIHT------ENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAF-- 117 Query: 1125 HCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHTTPA 1304 C + V HRDLK +N+L+ +GA KL DFG + F P E + T Sbjct: 118 -CHSHRVLHRDLKPQNLLINTEGAIKLADFGLA----RAFGVPVRTYTHEVV-----TLW 167 Query: 1305 YRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQILNGNYRIPELPKYC 1484 YRAPE+ L + S VDIW+LGC+ + ++ F G+S++ L +R P Sbjct: 168 YRAPEI--LLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTP--- 222 Query: 1485 SSITSLIEEMLQSSPDARPDITQVWFR 1565 ++ + S PD +P + W R Sbjct: 223 ---DEVVWPGVTSMPDYKPSFPK-WAR 245
>P23573:CDC2C_DROME Cell division control protein 2 cognate - Drosophila melanogaster| (Fruit fly) Length = 314 Score = 78.2 bits (191), Expect = 2e-13 Identities = 69/235 (29%), Positives = 107/235 (45%), Gaps = 2/235 (0%) Frame = +3 Query: 777 EAIAEGGFSCVYLARDLTNPAKHYALKHVIVQDKES--LDLVHKEITVMRALKGHPNVVT 950 E I EG + VY AR + + ALK + ++ + +EI++++ LK HPNVV Sbjct: 12 EKIGEGTYGIVYKARS-NSTGQDVALKKIRLEGETEGVPSTAIREISLLKNLK-HPNVVQ 69 Query: 951 LVAHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAMHC 1130 L I G ++ E+ L +D + + + + I +AV C Sbjct: 70 LFDVVI----SGNNLYMIFEYLNMDLKKLMDKKKDV--FTPQLIKSYMHQILDAVG--FC 121 Query: 1131 QTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHTTPAYR 1310 T + HRDLK +N+L+ G KL DFG + F+ P E + T YR Sbjct: 122 HTNRILHRDLKPQNLLVDTAGKIKLADFGLA----RAFNVPMRAYTHEVV-----TLWYR 172 Query: 1311 APEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQILNGNYRIPELP 1475 APE+ L + S VDIW+LGC+ + +S F G+S++ L +R P Sbjct: 173 APEI--LLGTKFYSTGVDIWSLGCIFSEMIMRRSLFPGDSEIDQLYRIFRTLSTP 225
>Q03428:NRKB_TRYBB Putative serine/threonine-protein kinase B - Trypanosoma brucei| brucei Length = 431 Score = 77.8 bits (190), Expect = 3e-13 Identities = 59/215 (27%), Positives = 101/215 (46%), Gaps = 8/215 (3%) Frame = +3 Query: 933 HPNVVTLVAHTILDMGRGREALLLMEFCER-SLVSALDARGT--AGFYDDEQVALIFRDI 1103 HPN++ + D L++MEF + +L + GT A ++ + + +F + Sbjct: 76 HPNIIRYIE----DHEENDRLLIVMEFADSGNLDEQIKPWGTGDARYFQEHEALFLFLQL 131 Query: 1104 CNAVFAMHCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDII 1283 C A+ +H + HRD+K+ NVLL + G KL DFG F E + + Sbjct: 132 CLALDYIHSHK--MLHRDIKSANVLLTSTGLVKLGDFG--------FSHQYEDTVSGVVA 181 Query: 1284 RKHT-TPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGES----KLQILN 1448 TP Y APE+W+ R ++K D+W+LG L+Y I +K F + ++L Sbjct: 182 STFCGTPYYLAPELWNNLR---YNKKADVWSLGVLLYEIMGMKKPFSASNLKGLMSKVLA 238 Query: 1449 GNYRIPELPKYCSSITSLIEEMLQSSPDARPDITQ 1553 G Y P + S +++ +L + P+ RP + + Sbjct: 239 GTY-APLPDSFSSEFKRVVDGILVADPNDRPSVRE 272
>P11837:NIMA_EMENI G2-specific protein kinase nimA - Emericella nidulans (Aspergillus| nidulans) Length = 699 Score = 77.8 bits (190), Expect = 3e-13 Identities = 67/262 (25%), Positives = 113/262 (43%), Gaps = 31/262 (11%) Frame = +3 Query: 852 LKHVIVQDKESLDLVHKEITVMRALKGHPNVVTLVAHTILDMGRGREALLLMEFCERSLV 1031 + ++ + KE L E ++ +L+ HPN+V L + + L ME+C + Sbjct: 42 INYIKMSTKEREQLT-AEFNILSSLR-HPNIVAYYHREHLKASQ--DLYLYMEYCGGGDL 97 Query: 1032 SAL--DARGTAGFYDDEQVALIFRDICNAVFAMHCQTPP--------------------- 1142 S + + + T + +++ V I + A++ H T P Sbjct: 98 SMVIKNLKRTNKYAEEDFVWRILSQLVTALYRCHYGTDPAEVGSNLLGPAPKPSGLKGKQ 157 Query: 1143 ----VAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHT-TPAY 1307 + HRDLK EN+ LG+D KL DFG H D + TP Y Sbjct: 158 AQMTILHRDLKPENIFLGSDNTVKLGDFGLSKLMH-----------SHDFASTYVGTPFY 206 Query: 1308 RAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQILN--GNYRIPELPK- 1478 +PE + E + + DIWA+GC+MY +C + F+ + +Q++ + LP Sbjct: 207 MSPE---ICAAEKYTLRSDIWAVGCIMYELCQREPPFNARTHIQLVQKIREGKFAPLPDF 263 Query: 1479 YCSSITSLIEEMLQSSPDARPD 1544 Y S + ++I L+ +PD RPD Sbjct: 264 YSSELKNVIASCLRVNPDHRPD 285
>P51956:NEK3_HUMAN Serine/threonine-protein kinase Nek3 - Homo sapiens (Human)| Length = 506 Score = 77.8 bits (190), Expect = 3e-13 Identities = 74/287 (25%), Positives = 124/287 (43%), Gaps = 13/287 (4%) Frame = +3 Query: 771 VREAIAEGGFSCVYLARDLTNPAKHYALKHVIVQDKESLDLVHKEITVMRALKGHPNVVT 950 V I EG F L + ++ + +A+K + + S ++ V+ A HPN+V Sbjct: 6 VLRMIGEGSFGRALLVQHESSN-QMFAMKEIRLPKSFSNTQNSRKEAVLLAKMKHPNIVA 64 Query: 951 LVAHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAMHC 1130 + ++ME+C+ + + + ++ + F +C V +H Sbjct: 65 FKESFEAE----GHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIHK 120 Query: 1131 QTPPVAHRDLKAENVLLGADGAWKLCDFGSVS--TNHKCFDKPEERGIEEDIIRKHTTPA 1304 + V HRD+K++N+ L +G KL DFGS +N F TP Sbjct: 121 KR--VLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAF-----------ACTYVGTPY 167 Query: 1305 YRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGES----KLQILNGNYRIPEL 1472 Y PE+W+ + K DIW+LGC++Y +C LK F S L++ G I L Sbjct: 168 YVPPEIWE---NLPYNNKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQG--CISPL 222 Query: 1473 PK-YCSSITSLIEEMLQSSPDARPDITQVWFR------VNELLPLEL 1592 P Y + L+++M + +P RP T + R V + LP E+ Sbjct: 223 PSHYSYELQFLVKQMFKRNPSHRPSATTLLSRGIVARLVQKCLPPEI 269
>P84199:NEK1_CAEEL Serine/threonine-protein kinase D1044.8 - Caenorhabditis elegans| Length = 959 Score = 77.8 bits (190), Expect = 3e-13 Identities = 83/325 (25%), Positives = 141/325 (43%), Gaps = 24/325 (7%) Frame = +3 Query: 750 VGNV-KVHVREAIAEGGFSCVYLARDLT-----NPAKHYALKHVIV-------QDKESLD 890 VG V + + + + G F CVY R NPAK ALK + + DK D Sbjct: 425 VGEVGEYELLDQLGAGAFGCVYTVRKKAQSHSENPAKLLALKEIFMTNLNDRESDKSFGD 484 Query: 891 LVHKEITVMRALKGHPNVVTLVAHTILDMGRGREALLLMEFCE-RSLVSALDARGTAGFY 1067 ++ E+ +++ HPN+V ++ R + L++ C R L+ + + G + Sbjct: 485 MI-SEVKIIKQQLRHPNIVRY-RRIFVENHRLYIVMDLIQGCSLRDLIITMKEK--KGNF 540 Query: 1068 DDEQVALIFRDICNAVFAMHCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFD 1247 +++++ + + A+ +H + + HRDLK N+++ D + DFG Sbjct: 541 EEKKIWAMVVQMMLALRYLH-KEKQIVHRDLKPNNIMMTTDERVVITDFGLA-------- 591 Query: 1248 KPEERGIEEDIIRKHTTPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGE 1427 +++G E + T Y PE + + EK DIW+ GC +Y +C L+ F Sbjct: 592 --KQKG-PEYLKSAAGTIIYSCPE---IVQNLPYGEKADIWSFGCCIYEMCQLQPVFHST 645 Query: 1428 SKL----QILNGNYRIPELPKYCSSITSLIEEMLQSSPDARPDITQV----WFRVNELLP 1583 + L QI+ Y P + + LI L P ARPDI +V R+ E L Sbjct: 646 NMLTLAMQIVEAKYD-PLNEMWSDDLRFLITSCLAPDPSARPDILKVSGMCGVRLLEYLD 704 Query: 1584 --LELQKDLPDGSPSGSAFELQITE 1652 Q D + S S++ ++I E Sbjct: 705 DVARQQASTSDMTASQSSYNIKIDE 729
>O55076:CDK2_CRIGR Cell division protein kinase 2 - Cricetulus griseus (Chinese hamster)| Length = 298 Score = 77.8 bits (190), Expect = 3e-13 Identities = 76/267 (28%), Positives = 121/267 (45%), Gaps = 4/267 (1%) Frame = +3 Query: 777 EAIAEGGFSCVYLARDLTNPAKHYALKHVIVQDKES--LDLVHKEITVMRALKGHPNVVT 950 E I EG + VY A++ + ALK + + + +EI++++ L HPN+V Sbjct: 8 EKIGEGTYGVVYKAKNKLT-GEVVALKKIRLDTETEGVPSTAIREISLLKELN-HPNIVK 65 Query: 951 L--VAHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAM 1124 L V HT + L+ EF + L +DA G + +F+ + F Sbjct: 66 LLDVIHT------ENKLYLVFEFLHQDLKKFMDASAVTGIPLPLIKSYLFQLLQGLAF-- 117 Query: 1125 HCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHTTPA 1304 C + V HRDLK +N+L+ A+G+ KL DFG + F P E + T Sbjct: 118 -CHSHRVLHRDLKPQNLLINAEGSIKLADFGLA----RAFGVPVRTYTHEVV-----TLW 167 Query: 1305 YRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQILNGNYRIPELPKYC 1484 YRAPE+ L + S VDIW+LGC+ + ++ F G+S++ L +R P Sbjct: 168 YRAPEI--LLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTP--- 222 Query: 1485 SSITSLIEEMLQSSPDARPDITQVWFR 1565 ++ + S PD +P + W R Sbjct: 223 ---DEVVWPGVTSMPDYKPSFPK-WAR 245
>Q3ULB5:PAK6_MOUSE Serine/threonine-protein kinase PAK 6 - Mus musculus (Mouse)| Length = 682 Score = 77.4 bits (189), Expect = 3e-13 Identities = 76/284 (26%), Positives = 135/284 (47%), Gaps = 8/284 (2%) Frame = +3 Query: 783 IAEGGFSCVYLARDLTNPAKHYALKHVIVQDKESLDLVHKEITVMRALKGHPNVVTLVAH 962 I EG V LAR+ + + A+K + ++ ++ +L+ E+ +MR + H NVV + Sbjct: 414 IGEGSTGIVCLARE-KHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQ-HLNVVEMYKS 471 Query: 963 TILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAMHCQTPP 1142 ++ G E +LMEF + ++ + ++ ++EQ+A + + A+ +H Q Sbjct: 472 YLV----GEELWVLMEFLQGGALTDIISQVRL---NEEQIATVCEAVLQALAYLHAQG-- 522 Query: 1143 VAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHTTPAYRAPEM 1322 V HRD+K++++LL DG KL DFG + K D P+ + + TP + APE Sbjct: 523 VIHRDIKSDSILLTLDGRVKLSDFGFCAQISK--DVPKRKSLV-------GTPYWMAPE- 572 Query: 1323 WDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQILNGNYRIPELPKYCSS---- 1490 + R + + +VDIW+LG ++ + + + +S +Q + R PK +S Sbjct: 573 --VISRSLYATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMK-RLRDSAPPKLKNSYKVS 629 Query: 1491 --ITSLIEEMLQSSPDARPDITQVWFRVNELL--PLELQKDLPD 1610 + ++ ML P R ELL P LQ LP+ Sbjct: 630 PVLRDFLDRMLVREPQERA-------TAQELLDHPFLLQTGLPE 666
>Q8TDX7:NEK7_HUMAN Serine/threonine-protein kinase Nek7 - Homo sapiens (Human)| Length = 302 Score = 77.4 bits (189), Expect = 3e-13 Identities = 81/279 (29%), Positives = 122/279 (43%), Gaps = 16/279 (5%) Frame = +3 Query: 771 VREAIAEGGFSCVYLARDLTNPAKHYALKHVIVQD----KESLDLVHKEITVMRALKGHP 938 + + I G FS VY A L + ALK V + D K D + KEI +++ L HP Sbjct: 36 IEKKIGRGQFSEVYRAACLLDGVP-VALKKVQIFDLMDAKARADCI-KEIDLLKQLN-HP 92 Query: 939 NVVTLVAHTILDMGRGREALLLMEFCERSLVSAL--DARGTAGFYDDEQVALIFRDICNA 1112 NV+ A I D E +++E + +S + + + V F +C+A Sbjct: 93 NVIKYYASFIED----NELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSA 148 Query: 1113 VFAMHCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKH 1292 + MH + V HRD+K NV + A G KL D G R H Sbjct: 149 LEHMHSRR--VMHRDIKPANVFITATGVVKLGDLGL------------GRFFSSKTTAAH 194 Query: 1293 T---TPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQILNGNYRI 1463 + TP Y +PE + K DIW+LGCL+Y + L+S F G+ K+ + + +I Sbjct: 195 SLVGTPYYMSPER---IHENGYNFKSDIWSLGCLLYEMAALQSPFYGD-KMNLYSLCKKI 250 Query: 1464 -----PELPK--YCSSITSLIEEMLQSSPDARPDITQVW 1559 P LP Y + L+ + P+ RPD+T V+ Sbjct: 251 EQCDYPPLPSDHYSEELRQLVNMCINPDPEKRPDVTYVY 289
>O13839:FIN1_SCHPO G2-specific protein kinase fin1 - Schizosaccharomyces pombe (Fission| yeast) Length = 722 Score = 77.4 bits (189), Expect = 3e-13 Identities = 79/293 (26%), Positives = 125/293 (42%), Gaps = 28/293 (9%) Frame = +3 Query: 762 KVHVREAIAEGGFSCVYLARDLTNPA----KHYALKHVIVQDKESLDLVHKEITVMRALK 929 K + E I G F +Y + L + A K ++ Q+K+ + E+ ++R LK Sbjct: 3 KYKILECIGHGSFGRIYKVQRLKDGALLAQKEIHFGNITRQEKQ---YIADEVNILRNLK 59 Query: 930 GHPNVVTLVAHTILDMGRGREAL-LLMEFCERSLVSALDAR--GTAGFYDDEQVALIFRD 1100 HPN+V ++ R + + L ME+C ++ L R + +++V F Sbjct: 60 -HPNIVQYCGE---ELNRSAQVINLYMEYCGHGDLANLIQRYKEEKKRFTEQEVLKFFTQ 115 Query: 1101 ICNAVFAMH---------CQTP--------PVAHRDLKAENVLLGADGAWKLCDFGSVST 1229 + A++ H Q P V HRD+K N+ L + + KL DFG Sbjct: 116 LLLALYRCHYGENAPACDSQWPREIFHPKQSVLHRDIKPANIFLDENNSVKLGDFGL--- 172 Query: 1230 NHKCFDKPEERGIEEDIIRKHTTPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLK 1409 K D R + + TP Y +PE + R S K D+WALGC+++ IC L Sbjct: 173 -SKLLDNT--RVFTQSYVG---TPYYMSPE---IIRSSPYSAKSDVWALGCVIFEICMLT 223 Query: 1410 SAFDGESKLQ----ILNGNYRIPELPKYCSSITSLIEEMLQSSPDARPDITQV 1556 F+G S L+ I GN + Y + LI L+ + D RP Q+ Sbjct: 224 HPFEGRSYLELQRNICQGNLSCWD-HHYSDDVFLLIRHCLEVNSDLRPTTYQL 275
>Q63699:CDK2_RAT Cell division protein kinase 2 - Rattus norvegicus (Rat)| Length = 298 Score = 77.4 bits (189), Expect = 3e-13 Identities = 76/267 (28%), Positives = 121/267 (45%), Gaps = 4/267 (1%) Frame = +3 Query: 777 EAIAEGGFSCVYLARDLTNPAKHYALKHVIVQDKES--LDLVHKEITVMRALKGHPNVVT 950 E I EG + VY A++ + ALK + + + +EI++++ L HPN+V Sbjct: 8 EKIGEGTYGVVYKAKNKLT-GEVVALKKIRLDTETEGVPSTAIREISLLKELN-HPNIVK 65 Query: 951 L--VAHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAM 1124 L V HT + L+ EF + L +DA G + +F+ + F Sbjct: 66 LLDVIHT------ENKLYLVFEFLHQDLKKFMDASALTGLPLPLIKSYLFQLLQGLAF-- 117 Query: 1125 HCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHTTPA 1304 C + V HRDLK +N+L+ A+G+ KL DFG + F P E + T Sbjct: 118 -CHSHRVLHRDLKPQNLLINAEGSIKLADFGLA----RAFGVPVRTYTHEVV-----TLW 167 Query: 1305 YRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQILNGNYRIPELPKYC 1484 YRAPE+ L + S VDIW+LGC+ + ++ F G+S++ L +R P Sbjct: 168 YRAPEI--LLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTP--- 222 Query: 1485 SSITSLIEEMLQSSPDARPDITQVWFR 1565 ++ + S PD +P + W R Sbjct: 223 ---DEVVWPGVTSMPDYKPSFPK-WAR 245
>O13945:PPK9_SCHPO Protein kinase domain-containing protein ppk9 - Schizosaccharomyces| pombe (Fission yeast) Length = 532 Score = 77.0 bits (188), Expect = 4e-13 Identities = 87/321 (27%), Positives = 138/321 (42%), Gaps = 10/321 (3%) Frame = +3 Query: 717 PSGGLEGRTIDVGNVKVH---VREAIAEGGFSCVYLARDLTNPAKHYALKHVI---VQDK 878 PS D GN V + + +G + V L + K ALK V ++DK Sbjct: 4 PSSASAESEKDSGNTYVGPWLLGRTLGQGNLAKVKLGKHFQTNEK-VALKMVYNDELEDK 62 Query: 879 ESLDLVHKEITVMRALKGHPNVVTLVAHTILDMGRGREALLLMEFCERSLVSALDARGTA 1058 ++ + +E+T++R L HPN++TL + + +L +E+ + L S + Sbjct: 63 DTWKRLQREVTILRQLH-HPNIITLYQVFRVP----KYTVLALEYMDTDLHSMVVKHNRL 117 Query: 1059 GFYDDEQVALIFRDICNAVFAMHCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHK 1238 D+ IFR I +A+ +C VAHRDLK EN+LL D KL DFG ++ Sbjct: 118 ---DECTTRKIFRQIVHAID--YCHLHRVAHRDLKLENILLNKDLVVKLTDFG---LSNF 169 Query: 1239 CFDKPEERGIEEDIIRKHTTPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAF 1418 D + TP Y APE+ + R VD+W G L+Y + + F Sbjct: 170 MLD-------GSFLSTSCGTPHYAAPEV--IQGRYYDGCDVDVWGCGILLYLMLVGEFPF 220 Query: 1419 DGESKLQILN----GNYRIPELPKYCSSITSLIEEMLQSSPDARPDITQVWFRVNELLPL 1586 + + +L+ G Y IP SS + LI +ML P +R + ++ + L Sbjct: 221 EDVTISNVLSRVCKGIYTIPSF--VSSSASDLIRQMLMVLPTSRIKVAEIMQHPWFIADL 278 Query: 1587 ELQKDLPDGSPSGSAFELQIT 1649 LP + S S+ +T Sbjct: 279 PTHSRLPSRTSSFSSKHRSVT 299
>Q641K5:NUAK1_MOUSE NUAK family SNF1-like kinase 1 - Mus musculus (Mouse)| Length = 658 Score = 77.0 bits (188), Expect = 4e-13 Identities = 69/234 (29%), Positives = 108/234 (46%), Gaps = 7/234 (2%) Frame = +3 Query: 876 KESLDLVH--KEITVMRALKGHPNVVTLVAHTILDMGRGREAL-LLMEFCERSLVSALDA 1046 K+ LD+VH +EI +M +L HP++++ I ++ ++ + ++ME+ + D Sbjct: 93 KDELDMVHIRREIEIMSSLN-HPHIIS-----IYEVFENKDKIVIIMEYASKG--ELYDY 144 Query: 1047 RGTAGFYDDEQVALIFRDICNAVFAMHCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVS 1226 + + FR I +AV +C V HRDLK EN+LL + K+ DFG + Sbjct: 145 ISERRRLSERETRHFFRQIVSAVH--YCHKNGVVHRDLKLENILLDDNCNIKIADFGLSN 202 Query: 1227 TNHKCFDKPEERGIEEDIIRKHTTPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYL 1406 K ++ + +P Y +PE+ + R +VD WALG L+Y + Y Sbjct: 203 LYQK----------DKFLQTFCGSPLYASPEI--VNGRPYRGPEVDSWALGVLLYTLIYG 250 Query: 1407 KSAFDGESK----LQILNGNYRIPELPKYCSSITSLIEEMLQSSPDARPDITQV 1556 FDG QI +G YR P P S LI ML +PD R I + Sbjct: 251 TMPFDGFDHKNLIRQISSGEYREPTQP---SDARGLIRWMLMVNPDRRATIEDI 301
>P43450:CDK2_CARAU Cell division protein kinase 2 - Carassius auratus (Goldfish)| Length = 298 Score = 76.6 bits (187), Expect = 6e-13 Identities = 76/266 (28%), Positives = 120/266 (45%), Gaps = 6/266 (2%) Frame = +3 Query: 777 EAIAEGGFSCVYLARDLTNPAKHYALKHVIVQDKES--LDLVHKEITVMRALKGHPNVVT 950 E I EG + VY A++ + ALK + + + +EI++++ L HPN+V Sbjct: 8 EKIGEGTYGVVYKAKNKVT-GETVALKKIRLDTETEGVPSTAIREISLLKELN-HPNIVK 65 Query: 951 L--VAHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAM 1124 L V HT + L+ EF + L +D+ G + +F+ + F Sbjct: 66 LHDVIHT------ENKLYLVFEFLHQDLKRFMDSSTVTGISLPLVKSYLFQLLQGLAF-- 117 Query: 1125 HCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHTTPA 1304 C + V HRDLK +N+L+ A G KL DFG + F P E + T Sbjct: 118 -CHSHRVLHRDLKPQNLLINAQGEIKLADFGLA----RAFGVPVRTYTHEVV-----TLW 167 Query: 1305 YRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQILNGNYRIPELP--K 1478 YRAPE+ L + S VDIW+LGC+ + K+ F G+S++ L +R P Sbjct: 168 YRAPEI--LLGCKYYSTAVDIWSLGCIFAEMITRKALFPGDSEIDQLFRIFRTLGTPDES 225 Query: 1479 YCSSITSLIEEMLQSSPDARPDITQV 1556 +TS+ + AR D+++V Sbjct: 226 IWPGVTSMPDYKPSFPKWARQDLSKV 251
>Q9ES70:NEK6_MOUSE Serine/threonine-protein kinase Nek6 - Mus musculus (Mouse)| Length = 313 Score = 76.3 bits (186), Expect = 7e-13 Identities = 80/277 (28%), Positives = 121/277 (43%), Gaps = 15/277 (5%) Frame = +3 Query: 771 VREAIAEGGFSCVYLARDLTNPAKHYALKHVIV---QDKESLDLVHKEITVMRALKGHPN 941 + + I G FS VY A L + K ALK V + D ++ KEI +++ L HPN Sbjct: 47 IEKKIGRGQFSEVYKATCLLD-RKTVALKKVQIFEMMDAKARQDCVKEIGLLKQLN-HPN 104 Query: 942 VVTLVAHTILDMGRGREALLLMEFCERSLVSALDA--RGTAGFYDDEQVALIFRDICNAV 1115 ++ + I D E +++E + +S + + + V F +C+AV Sbjct: 105 IIKYLDSFIED----NELNIVLELADAGDLSQMIKYFKKQKRLIPERTVWKYFVQLCSAV 160 Query: 1116 FAMHCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHT 1295 MH + V HRD+K NV + A G KL D G R + H+ Sbjct: 161 EHMHSRR--VMHRDIKPANVFITATGIVKLGDLGL------------GRFFSSETTAAHS 206 Query: 1296 ---TPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQILNGNYRI- 1463 TP Y +PE + K DIW+LGCL+Y + L+S F G+ K+ + + +I Sbjct: 207 LVGTPYYMSPER---IHENGYNFKSDIWSLGCLLYEMAALQSPFYGD-KMNLFSLCQKIE 262 Query: 1464 ----PELP--KYCSSITSLIEEMLQSSPDARPDITQV 1556 P LP Y + L+ + PD RPDI V Sbjct: 263 QCDYPPLPGEHYSEKLRELVSMCIYPDPDHRPDIVYV 299
>O55099:AURKB_RAT Serine/threonine-protein kinase 12 - Rattus norvegicus (Rat)| Length = 343 Score = 76.3 bits (186), Expect = 7e-13 Identities = 79/278 (28%), Positives = 124/278 (44%), Gaps = 15/278 (5%) Frame = +3 Query: 783 IAEGGFSCVYLARDLTNPAKHYALKHVIVQDKESLDLVH---KEITVMRALKGHPNVVTL 953 + +G F VYLAR+ + ALK + E + H +EI + LK HPN++ L Sbjct: 86 LGKGKFGNVYLAREKKSRFI-VALKILFKSQIEKEGVEHQLRREIEIQAHLK-HPNILQL 143 Query: 954 VAHTILDMGRGREALLLMEFCERS-LVSALDARGTAGFYDDEQVALIFRDICNAVFAMHC 1130 + D R L++E+ R L L GT +D+++ A I ++ +A+ M+C Sbjct: 144 YNY-FYDQQR---IYLILEYAPRGELYKELQKSGT---FDEQRTATIMEELSDAL--MYC 194 Query: 1131 QTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHT---TP 1301 V HRD+K EN+LLG G K+ DFG + +R+ T T Sbjct: 195 HKKKVIHRDIKPENLLLGLQGELKIADFG--------------WSVHAPSLRRKTMCGTL 240 Query: 1302 AYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQILNGNYRIPELPKY 1481 Y PEM + +E VD+W +G L Y + F+ S + ++ K+ Sbjct: 241 DYLPPEM---IEGRMHNEMVDLWCIGVLCYELMVGNPPFESPSHSETYRRIVKVD--LKF 295 Query: 1482 CSSI----TSLIEEMLQSSPDARPDITQV----WFRVN 1571 SS+ LI ++L+ +P R + QV W R N Sbjct: 296 PSSMPLGAKDLISKLLKHNPSQRLPLEQVSAHPWVRAN 333
>Q9N0X0:AURKB_PIG Serine/threonine-protein kinase 12 - Sus scrofa (Pig)| Length = 344 Score = 76.3 bits (186), Expect = 7e-13 Identities = 85/328 (25%), Positives = 142/328 (43%), Gaps = 19/328 (5%) Frame = +3 Query: 681 PFRQLMPKEHSGPSGGLEGRTIDVGNVKVHVREAIAEGGFSCVYLARDLTNPAKHY--AL 854 P ++++ P+ TID + + +G F VYLAR+ + H+ AL Sbjct: 53 PGQKVVENSSGTPNFSTRSFTID----DFEIGRPLGKGKFGNVYLAREKKS---HFIVAL 105 Query: 855 KHVIVQDKESLDLVH---KEITVMRALKGHPNVVTLVAHTILDMGRGREALLLMEFCERS 1025 K + E + H +EI + L+ HPN++ L + R L++E+ R Sbjct: 106 KVLFKSQIEKEGVEHQLRREIEIQAHLQ-HPNILRLYNYFY----DRRRIYLILEYAPRG 160 Query: 1026 -LVSALDARGTAGFYDDEQVALIFRDICNAVFAMHCQTPPVAHRDLKAENVLLGADGAWK 1202 L L T +D+++ A I ++ +A+ ++C V HRD+K EN+LLG G K Sbjct: 161 ELYKELQKCRT---FDEQRTATIMEELADAL--IYCHGKKVIHRDIKPENLLLGLQGELK 215 Query: 1203 LCDFGSVSTNHKCFDKPEERGIEEDIIRKHT---TPAYRAPEMWDLYRREVISEKVDIWA 1373 + DFG + +R+ T T Y PEM +EKVD+W Sbjct: 216 IADFG--------------WSVHAPSLRRKTMCGTLDYLPPEM---IEGRTHNEKVDLWC 258 Query: 1374 LGCLMYRICY----LKSAFDGESKLQILNGNYRIPELPKYCSSITSLIEEMLQSSPDARP 1541 +G L Y + +SA E+ +I + + P P + LI ++L+ +P R Sbjct: 259 IGVLCYELLVGNPPFESASHNETYRRIGKVDLKFP--PSVPAGAQDLISKLLKHNPSDRL 316 Query: 1542 DITQV----WFRVN--ELLPLELQKDLP 1607 + QV W R + +LP + +P Sbjct: 317 PLAQVSAHPWVRAHSRRVLPPSAPQSVP 344
>Q96GD4:AURKB_HUMAN Serine/threonine-protein kinase 12 - Homo sapiens (Human)| Length = 344 Score = 76.3 bits (186), Expect = 7e-13 Identities = 78/280 (27%), Positives = 125/280 (44%), Gaps = 17/280 (6%) Frame = +3 Query: 783 IAEGGFSCVYLARDLTNPAKHY--ALKHVIVQDKESLDLVH---KEITVMRALKGHPNVV 947 + +G F VYLAR+ + H+ ALK + E + H +EI + L HPN++ Sbjct: 83 LGKGKFGNVYLAREKKS---HFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLH-HPNIL 138 Query: 948 TLVAHTILDMGRGREALLLMEFCERS-LVSALDARGTAGFYDDEQVALIFRDICNAVFAM 1124 L + R L++E+ R L L T +D+++ A I ++ +A+ M Sbjct: 139 RLYNYFY----DRRRIYLILEYAPRGELYKELQKSCT---FDEQRTATIMEELADAL--M 189 Query: 1125 HCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHT--- 1295 +C V HRD+K EN+LLG G K+ DFG + +R+ T Sbjct: 190 YCHGKKVIHRDIKPENLLLGLKGELKIADFG--------------WSVHAPSLRRKTMCG 235 Query: 1296 TPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICY----LKSAFDGESKLQILNGNYRI 1463 T Y PEM + +EKVD+W +G L Y + +SA E+ +I+ + + Sbjct: 236 TLDYLPPEM---IEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKF 292 Query: 1464 PELPKYCSSITSLIEEMLQSSPDARPDITQV----WFRVN 1571 P + LI ++L+ +P R + QV W R N Sbjct: 293 P--ASVPTGAQDLISKLLRHNPSERLPLAQVSAHPWVRAN 330
>O14299:WIS4_SCHPO MAP kinase kinase kinase wis4 - Schizosaccharomyces pombe (Fission| yeast) Length = 1401 Score = 75.9 bits (185), Expect = 1e-12 Identities = 71/244 (29%), Positives = 111/244 (45%), Gaps = 13/244 (5%) Frame = +3 Query: 849 ALKHVIVQD----KESLDLVHKEITVMRALKGHPNVVTLVAHTILDMGRGREALLLMEFC 1016 A+K + +QD + ++D +H E+TV+ L HPNVVT + + + MEFC Sbjct: 1064 AVKEIKLQDSRTFRSTVDQIHNEMTVLERLN-HPNVVTYYGVEV----HREKVYIFMEFC 1118 Query: 1017 ERSLVSALDARGTAGFYDDEQVALIFR-DICNAVFAMHCQTPPVAHRDLKAENVLLGADG 1193 + ++ L A G +DE V ++ + + +H Q + HRD+K N+LL G Sbjct: 1119 QGGSLADLLAHGRI---EDENVLKVYVVQLLEGLAYIHSQH--ILHRDIKPANILLDHRG 1173 Query: 1194 AWKLCDFGSVSTNHKCFDKPEER--GIEEDIIRKHTTPAYRAPEMWDLYRREVISEKVDI 1367 K DFGS D PE R I+ ++ TP Y APE+ L ++ +DI Sbjct: 1174 MIKYSDFGSALYVSPPTD-PEVRYEDIQPELQHLAGTPMYMAPEI-ILGTKKGDFGAMDI 1231 Query: 1368 WALGCLMYRICYLK---SAFDGESKLQILNGNYRIPELP---KYCSSITSLIEEMLQSSP 1529 W+LGC++ + S D E + P +P K S IE+ + P Sbjct: 1232 WSLGCVILEMMTGSTPWSEMDNEWAIMYHVAAMHTPSIPQNEKISSLARDFIEQCFERDP 1291 Query: 1530 DARP 1541 + RP Sbjct: 1292 EQRP 1295
>Q91819:STK6L_XENLA Serine/threonine-protein kinase Eg2-like - Xenopus laevis (African| clawed frog) Length = 408 Score = 75.9 bits (185), Expect = 1e-12 Identities = 71/268 (26%), Positives = 118/268 (44%), Gaps = 16/268 (5%) Frame = +3 Query: 783 IAEGGFSCVYLARDLTNPAKHYALKHVIVQDKESLDLVH---KEITVMRALKGHPNVVTL 953 + +G F VYLAR+ + ALK + E + H +E+ + L+ HPN++ L Sbjct: 146 LGKGKFGNVYLARERESKFI-LALKVLFKSQLEKAGVEHQLRREVEIQSHLR-HPNILRL 203 Query: 954 VAH--------TILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICN 1109 + ILD G E ++ C R +DD++ AL + + Sbjct: 204 YGYFHDASRVYLILDYAPGGELFRELQKCTR--------------FDDQRSALYIKQLAE 249 Query: 1110 AVFAMHCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRK 1289 A+ ++C + V HRD+K EN+LLG++G K+ DFG + R+ Sbjct: 250 AL--LYCHSKKVIHRDIKPENLLLGSNGELKIADFG--------------WSVHAPSSRR 293 Query: 1290 HT---TPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQILNGNYR 1460 T T Y PEM + EKVD+W+LG L Y K F+ ++ + + Sbjct: 294 TTLCGTLDYLPPEM---IEGRMHDEKVDLWSLGVLCYEFLVGKPPFETDTHQETYRRISK 350 Query: 1461 IP-ELPKYCS-SITSLIEEMLQSSPDAR 1538 + + P Y S L+ ++L+ +P+ R Sbjct: 351 VEFQYPPYVSEEAKDLVSKLLKHNPNHR 378
>Q92212:STE20_CANAL Serine/threonine-protein kinase CST20 - Candida albicans (Yeast)| Length = 1228 Score = 75.9 bits (185), Expect = 1e-12 Identities = 63/263 (23%), Positives = 121/263 (46%), Gaps = 5/263 (1%) Frame = +3 Query: 783 IAEGGFSCVYLARDLTNPAKHYALKHVIVQDKESLDLVHKEITVMRALKGHPNVVTLVAH 962 I +G V+LA D+ + + A+K + ++ + +L+ EI VM+ HPN+V + Sbjct: 957 IGQGASGGVFLAHDVRDKSNIVAIKQMNLEQQPKKELIINEILVMKG-SSHPNIVNFIDS 1015 Query: 963 TILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAMHCQTPP 1142 +L + ++ME+ E ++ + T + Q+ ++ R+ + +H + Sbjct: 1016 YLLK----GDLWVIMEYMEGGSLTDIV---THSVMTEGQIGVVCRETLKGLKFLHSKG-- 1066 Query: 1143 VAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHTTPAYRAPEM 1322 V HRD+K++N+LL DG K+ DFG + ++ I I TP + APE Sbjct: 1067 VIHRDIKSDNILLNMDGNIKITDFGFCAQINE---------INSKRITMVGTPYWMAPE- 1116 Query: 1323 WDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQIL-----NGNYRIPELPKYCS 1487 + R+ KVD+W+LG ++ + + + E+ L+ L NG ++ + Sbjct: 1117 --IVSRKEYGPKVDVWSLGIMIIEMLEGEPPYLNETPLRALYLIATNGTPKLKDPESLSY 1174 Query: 1488 SITSLIEEMLQSSPDARPDITQV 1556 I + LQ + R D ++ Sbjct: 1175 DIRKFLAWCLQVDFNKRADADEL 1197
>Q9IA88:SN1L2_CHICK Serine/threonine-protein kinase SNF1-like kinase 2 - Gallus gallus| (Chicken) Length = 798 Score = 75.9 bits (185), Expect = 1e-12 Identities = 72/269 (26%), Positives = 128/269 (47%), Gaps = 7/269 (2%) Frame = +3 Query: 771 VREAIAEGGFSCVYLARDLTNPAKHYALKHVIVQ--DKESLDLVHKEITVMRALKGHPNV 944 + + +G F+ V LAR + A+K + D +L+ +++E+ +M+ L HP++ Sbjct: 28 IERTLGKGNFAVVKLARHRVTKTQ-VAIKIIDKTRLDPSNLEKIYREVQIMKLLN-HPHI 85 Query: 945 VTLVAHTILDMGRGREALLLM-EFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFA 1121 + L + +++ ++ L ++ EF + D + G + + F I +AV Sbjct: 86 IKL--YQVMET---KDMLYIVTEFAKNG--EMFDHLTSNGHLSESEARKKFWQILSAV-- 136 Query: 1122 MHCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHTTP 1301 +C + + HRDLK EN+LL A+ KL DFG F + G E + +P Sbjct: 137 EYCHSHHIVHRDLKTENLLLDANMNIKLADFG--------FGNFYKSG--EPLSTWCGSP 186 Query: 1302 AYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGES----KLQILNGNYRIPE 1469 Y APE+++ +E +DIW+LG ++Y + FDG + + ++L G +RIP Sbjct: 187 PYAAPEVFE--GKEYEGPHLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPY 244 Query: 1470 LPKYCSSITSLIEEMLQSSPDARPDITQV 1556 +LI ML P R I+Q+ Sbjct: 245 F--MSEDCETLIRRMLVVDPTKRITISQI 271
>Q9ES74:NEK7_MOUSE Serine/threonine-protein kinase Nek7 - Mus musculus (Mouse)| Length = 302 Score = 75.9 bits (185), Expect = 1e-12 Identities = 87/309 (28%), Positives = 131/309 (42%), Gaps = 16/309 (5%) Frame = +3 Query: 681 PFRQLMPKEHSGPSGGLEGRTIDVGNVKVHVREAIAEGGFSCVYLARDLTNPAKHYALKH 860 P Q P++ P G + N ++ + I G FS VY A L + ALK Sbjct: 12 PVTQFQPQKALRPDMGYN----TLANFRIEKK--IGRGQFSEVYRASCLLDGVP-VALKK 64 Query: 861 VIVQD----KESLDLVHKEITVMRALKGHPNVVTLVAHTILDMGRGREALLLMEFCERSL 1028 V + D K D + KEI +++ L HPNV+ A I D E +++E + Sbjct: 65 VQIFDLMDAKARADCI-KEIDLLKQLN-HPNVIKYYASFIED----NELNIVLELADAGD 118 Query: 1029 VSAL--DARGTAGFYDDEQVALIFRDICNAVFAMHCQTPPVAHRDLKAENVLLGADGAWK 1202 +S + + + V F +C+A+ MH + V HRD+K NV + A G K Sbjct: 119 LSRMIKHFKKQKRLIPERTVWKYFVQLCSALDHMHSRR--VMHRDIKPANVFITATGVVK 176 Query: 1203 LCDFGSVSTNHKCFDKPEERGIEEDIIRKHT---TPAYRAPEMWDLYRREVISEKVDIWA 1373 L D G R H+ TP Y +PE + K DIW+ Sbjct: 177 LGDLGL------------GRFFSSKTTAAHSLVGTPYYMSPER---IHENGYNFKSDIWS 221 Query: 1374 LGCLMYRICYLKSAFDGESKLQILNGNYRI-----PELPK--YCSSITSLIEEMLQSSPD 1532 LGCL+Y + L+S F G+ K+ + + +I P LP Y + L+ + P+ Sbjct: 222 LGCLLYEMAALQSPFYGD-KMNLYSLCKKIEQCDYPPLPSDHYSEELRQLVNICINPDPE 280 Query: 1533 ARPDITQVW 1559 RPDI V+ Sbjct: 281 KRPDIAYVY 289
>P54119:CDC2_AJECA Cell division control protein 2 - Ajellomyces capsulata (Histoplasma| capsulatum) Length = 324 Score = 75.9 bits (185), Expect = 1e-12 Identities = 70/238 (29%), Positives = 114/238 (47%), Gaps = 18/238 (7%) Frame = +3 Query: 777 EAIAEGGFSCVYLARDLTNPAKHYALKHVIVQ--DKESLDLVHKEITVMRALKGHPNVVT 950 E I EG + VY ARDLT+P + ALK + ++ D+ +EI++++ + PN+V Sbjct: 8 EKIGEGTYGVVYKARDLTHPNRIVALKKIRLEAEDEGVPSTAIREISLLKEMHD-PNIVR 66 Query: 951 LVAHTILDMGRGREALLLMEFCERSLVSALDA-------RGTA----GFYDDEQV----A 1085 L+ D G + L+ EF + L ++A RG A D ++ A Sbjct: 67 LLNIVHAD---GHKLYLVFEFLDLDLKKYMEALPVSEGGRGKALPDGSTLDMNRLGLGEA 123 Query: 1086 LIFRDICNAVFAM-HCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEER 1262 ++ + + V + +C + V HRDLK +N+L+ +G KL DFG + F P Sbjct: 124 MVKKFMAQLVEGIRYCHSHRVLHRDLKPQNLLIDREGNLKLADFGLA----RAFGVPLRT 179 Query: 1263 GIEEDIIRKHTTPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKL 1436 E + T YRAPE+ L S VD+W++G + +C K F G+S++ Sbjct: 180 YTHEVV-----TLWYRAPEI--LLGGRQYSTGVDMWSVGAIFAEMCTRKPLFPGDSEI 230
>P50526:SSP1_SCHPO Serine/threonine-protein kinase ssp1 - Schizosaccharomyces pombe| (Fission yeast) Length = 652 Score = 75.5 bits (184), Expect = 1e-12 Identities = 68/233 (29%), Positives = 107/233 (45%), Gaps = 12/233 (5%) Frame = +3 Query: 894 VHKEITVMRALKGHPNVVTLVAHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDD 1073 V +EI +++ HPNVV L ++D + L++E+ V D Sbjct: 187 VRREIAILKKCV-HPNVVRL--REVIDDPSSTKVYLVLEYMSGGEVPWTDCDSPV--LSI 241 Query: 1074 EQVALIFRDICNAVFAMHCQTPPVAHRDLKAENVLLGADGAWKLCDFG-SVSTNHKCFDK 1250 + FRD+ + +H Q + HRD+K N+LL + K+ DFG S N Sbjct: 242 SEARQYFRDVVLGLEYLHYQG--IIHRDIKPANLLLNSSNCVKISDFGVSYIAN------ 293 Query: 1251 PEERGIEED----IIRKHTTPAYRAPEM-W-DLYR-REVISEKVDIWALG----CLMYRI 1397 G+ ED + + TPA+ APE+ W DL R R ISE +D+WALG CL++ Sbjct: 294 ---AGLNEDNDVELAKTVGTPAFFAPELCWTDLDRPRPKISEAIDVWALGVTLFCLLFGR 350 Query: 1398 CYLKSAFDGESKLQILNGNYRIPELPKYCSSITSLIEEMLQSSPDARPDITQV 1556 C ++ + E +I+N IP P L++ +L P+ R + +V Sbjct: 351 CPFNASMEYELFDKIVNERLNIPSTPDIGEEGRDLLKRLLCKDPEQRITLVEV 403
>Q9VXE5:PAKM_DROME Serine/threonine-protein kinase PAK mbt - Drosophila melanogaster| (Fruit fly) Length = 639 Score = 75.5 bits (184), Expect = 1e-12 Identities = 70/257 (27%), Positives = 121/257 (47%), Gaps = 5/257 (1%) Frame = +3 Query: 783 IAEGGFSCVYLARDLTNPAKHYALKHVIVQDKESLDLVHKEITVMRALKGHPNVVTLVAH 962 I EG V +A D + + A+K + ++ ++ +L+ E+ +MR HPN+V + Sbjct: 374 IGEGSTGTVCIATDKST-GRQVAVKKMDLRKQQRRELLFNEVVIMRDYH-HPNIVETYSS 431 Query: 963 TILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAMHCQTPP 1142 +++ E ++ME+ E AL T D+EQ+A + + A+ +H Q Sbjct: 432 FLVN----DELWVVMEYLEGG---ALTDIVTHSRMDEEQIATVCKQCLKALAYLHSQG-- 482 Query: 1143 VAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHTTPAYRAPEM 1322 V HRD+K++++LL ADG KL DFG C +E + ++ TP + +PE Sbjct: 483 VIHRDIKSDSILLAADGRVKLSDFGF------CAQVSQELPKRKSLV---GTPYWMSPE- 532 Query: 1323 WDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQILN--GNYRIPELP---KYCS 1487 + R +VDIW+LG ++ + + F E LQ + + + P L K Sbjct: 533 --VISRLPYGPEVDIWSLGIMVIEMVDGEPPFFNEPPLQAMRRIRDMQPPNLKNAHKVSP 590 Query: 1488 SITSLIEEMLQSSPDAR 1538 + S ++ ML P R Sbjct: 591 RLQSFLDRMLVRDPAQR 607
>Q91ZR4:NEK8_MOUSE Serine/threonine-protein kinase Nek8 - Mus musculus (Mouse)| Length = 698 Score = 75.5 bits (184), Expect = 1e-12 Identities = 67/270 (24%), Positives = 118/270 (43%), Gaps = 12/270 (4%) Frame = +3 Query: 783 IAEGGFSCVYLARDLTNPAKHYALKHVIVQD--KESLDLVHKEITVMRALKGHPNVVTLV 956 + G F V+L + K LK + V+ KE E V++ L HPNV+ Sbjct: 10 VGRGAFGIVHLCLRKADQ-KLVILKQIPVEQMTKEERQAAQNECQVLKLLN-HPNVIEYY 67 Query: 957 AHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAMHCQT 1136 + + D + ++ ME+ ++ + ++E + F I A+ +H T Sbjct: 68 ENFLED----KALMIAMEYAPGGTLAEFIQKRCNSLLEEETILHFFVQILLALHHVH--T 121 Query: 1137 PPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHT------T 1298 + HRDLK +N+LL H+ K + GI + + K T Sbjct: 122 HLILHRDLKTQNILLD---------------KHRMVVKIGDFGISKILSSKSKAYTVVGT 166 Query: 1299 PAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGES----KLQILNGNYRIP 1466 P Y +PE+ + + ++K DIWALGC++Y + LK AF+ + L+I++G + P Sbjct: 167 PCYISPELCE---GKPYNQKSDIWALGCVLYELASLKRAFEAANLPALVLKIMSGTF-AP 222 Query: 1467 ELPKYCSSITSLIEEMLQSSPDARPDITQV 1556 +Y + L+ +L P RP ++ + Sbjct: 223 ISDRYSPELRQLVLSLLSLEPAQRPPLSHI 252
>Q9Z1J2:NEK4_MOUSE Serine/threonine-protein kinase Nek4 - Mus musculus (Mouse)| Length = 792 Score = 75.5 bits (184), Expect = 1e-12 Identities = 74/269 (27%), Positives = 119/269 (44%), Gaps = 11/269 (4%) Frame = +3 Query: 783 IAEGGFSCVYLARDLTNPAKHYALKHVIVQDKESLD--LVHKEITVMRALKGHPNVVTLV 956 + G + V L + + K Y +K + +++ S + +E ++ LK HPN+VT Sbjct: 12 VGRGSYGEVTLVKHRRD-GKQYVIKKLNLRNASSRERRAAEQEAQLLSQLK-HPNIVTYK 69 Query: 957 AHTILDMGRGREALL--LMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAMHC 1130 + G + LL +M FCE + + QV F I A+ +H Sbjct: 70 -----ESWEGGDGLLYIVMGFCEGGDLYRKLKEQKGQLLPESQVVEWFVQIAMALQYLH- 123 Query: 1131 QTPPVAHRDLKAENVLLGADGAWKLCDFG--SVSTNHKCFDKPEERGIEEDIIRKHTTPA 1304 + HRDLK +NV L K+ D G V NH + +I TP Sbjct: 124 -EKHILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHG--------DMASTLIG---TPY 171 Query: 1305 YRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESK----LQILNGNYRIPEL 1472 Y +PE L+ + + K D+WALGC +Y + LK AF+ + +I+ G ++P + Sbjct: 172 YMSPE---LFSNKPYNYKSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIIEG--KLPPM 226 Query: 1473 PK-YCSSITSLIEEMLQSSPDARPDITQV 1556 PK Y + + LI ML P+ RP + + Sbjct: 227 PKVYSTELAELIRTMLSRRPEERPSVRSI 255
>Q05609:CTR1_ARATH Serine/threonine-protein kinase CTR1 - Arabidopsis thaliana| (Mouse-ear cress) Length = 821 Score = 75.5 bits (184), Expect = 1e-12 Identities = 66/284 (23%), Positives = 127/284 (44%), Gaps = 7/284 (2%) Frame = +3 Query: 726 GLEGRTIDVGNVKVHVREAIAEGGFSCVYLARDLTNPAKHYALKHVIVQD--KESLDLVH 899 GL+G +D+ ++++E I G F V+ A A+K ++ QD E ++ Sbjct: 538 GLDGDDMDIPWCDLNIKEKIGAGSFGTVHRAEW---HGSDVAVKILMEQDFHAERVNEFL 594 Query: 900 KEITVMRALKGHPNVVTLVAHTILDMGRGREALLLMEFCER-SLVSALDARGTAGFYDDE 1076 +E+ +M+ L+ HPN+V + + ++ E+ R SL L G D+ Sbjct: 595 REVAIMKRLR-HPNIVLFMGAVT----QPPNLSIVTEYLSRGSLYRLLHKSGAREQLDER 649 Query: 1077 QVALIFRDICNAVFAMHCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPE 1256 + + D+ + +H + PP+ HRDLK+ N+L+ K+CDFG F + Sbjct: 650 RRLSMAYDVAKGMNYLHNRNPPIVHRDLKSPNLLVDKKYTVKVCDFGLSRLKASTFLSSK 709 Query: 1257 ERGIEEDIIRKHTTPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKL 1436 TP + APE + R E +EK D+++ G +++ + L+ + + Sbjct: 710 SAA---------GTPEWMAPE---VLRDEPSNEKSDVYSFGVILWELATLQQPWGNLNPA 757 Query: 1437 QILNG---NYRIPELPKYCS-SITSLIEEMLQSSPDARPDITQV 1556 Q++ + E+P+ + + ++IE + P RP + Sbjct: 758 QVVAAVGFKCKRLEIPRNLNPQVAAIIEGCWTNEPWKRPSFATI 801
>Q6X4A2:CIPK1_ORYSJ CIPK-like protein 1 - Oryza sativa subsp. japonica (Rice)| Length = 449 Score = 75.5 bits (184), Expect = 1e-12 Identities = 79/281 (28%), Positives = 125/281 (44%), Gaps = 13/281 (4%) Frame = +3 Query: 762 KVHVREAIAEGGFSCVYLARDLTN--PAKHYALKHVIVQDKESLDLVHKEITVMRALKGH 935 K + I EG F+ V A++ N P L VQ ++ + +EI M+ +K H Sbjct: 19 KYELGRTIGEGTFAKVRFAKNTENDEPVAIKILDKEKVQKHRLVEQIRREICTMKLVK-H 77 Query: 936 PNVVTLVAHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAV 1115 PNVV L MG +++E+ + + A T G +E+ F+ + NAV Sbjct: 78 PNVVRLFEV----MGSKARIFIVLEYVTGGELFEIIA--TNGRLKEEEARKYFQQLINAV 131 Query: 1116 FAMHCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHT 1295 +C + V HRDLK EN+LL A G K+ DFG + + ++ D + T Sbjct: 132 D--YCHSRGVYHRDLKLENLLLDASGNLKVSDFGLSALTEQ---------VKADGLLHTT 180 Query: 1296 --TPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQILNGNYRIPE 1469 TP Y APE+ + R DIW+ G ++Y + F+ ++ + + +I E Sbjct: 181 CGTPNYVAPEV--IEDRGYDGAAADIWSCGVILYVLLAGFLPFEDDNIIALYK---KISE 235 Query: 1470 LPKYCSSITS-----LIEEMLQSSPDARPDITQV----WFR 1565 C S S LI +L +P R I+Q+ WF+ Sbjct: 236 AQFTCPSWFSTGAKKLITRILDPNPTTRITISQILEDPWFK 276
>P48963:CDK2_MESAU Cell division protein kinase 2 - Mesocricetus auratus (Golden| hamster) Length = 298 Score = 75.5 bits (184), Expect = 1e-12 Identities = 75/267 (28%), Positives = 120/267 (44%), Gaps = 4/267 (1%) Frame = +3 Query: 777 EAIAEGGFSCVYLARDLTNPAKHYALKHVIVQDKES--LDLVHKEITVMRALKGHPNVVT 950 E I EG + VY A++ + ALK + + + +EI++++ L HPN+V Sbjct: 8 EKIGEGTYGVVYKAKNKLT-GEVVALKKIRLDTETEGVPSTAIREISLLKELN-HPNIVK 65 Query: 951 L--VAHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAM 1124 L V HT + L+ E + L +DA G + +F+ + F Sbjct: 66 LLDVIHT------ENKLYLVFELLHQDLKKFMDASAVTGIPLPLIKSYLFQLLQGLAF-- 117 Query: 1125 HCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHTTPA 1304 C + V HRDLK +N+L+ A+G+ KL DFG + F P E + T Sbjct: 118 -CHSHRVLHRDLKPQNLLINAEGSIKLADFGLA----RAFGVPVRTYTHEVV-----TLW 167 Query: 1305 YRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQILNGNYRIPELPKYC 1484 YRAPE+ L + S VDIW+LGC+ + ++ F G+S++ L +R P Sbjct: 168 YRAPEI--LLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTP--- 222 Query: 1485 SSITSLIEEMLQSSPDARPDITQVWFR 1565 ++ + S PD +P + W R Sbjct: 223 ---DEVVWPGVTSMPDYKPSFPK-WAR 245
>P51958:CDC2_CARAU Cell division control protein 2 homolog - Carassius auratus| (Goldfish) Length = 302 Score = 75.5 bits (184), Expect = 1e-12 Identities = 66/225 (29%), Positives = 103/225 (45%), Gaps = 2/225 (0%) Frame = +3 Query: 777 EAIAEGGFSCVYLARDLTNPAKHYALKHVIVQDKES--LDLVHKEITVMRALKGHPNVVT 950 E I EG + VY R+ T + A+K + ++ +E +EI++++ L+ HPNVV Sbjct: 8 EKIGEGTYGVVYKGRNKTT-GQVVAMKKIRLESEEEGVPSTAVREISLLKELQ-HPNVVR 65 Query: 951 LVAHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAMHC 1130 L+ + + + L+ EF L LD+ + F D V I + HC Sbjct: 66 LLDVLMQES----KLYLVFEFLSMDLKKYLDSIPSGQFMDPMLVKSYLYQILEGILFCHC 121 Query: 1131 QTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHTTPAYR 1310 + V HRDLK +N+L+ G KL DFG + F P E + T YR Sbjct: 122 RR--VLHRDLKPQNLLIDNKGVIKLADFGLA----RAFGVPVRVYTHEVV-----TLWYR 170 Query: 1311 APEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQIL 1445 APE+ L S VD+W++G + + K F G+S++ L Sbjct: 171 APEV--LLGASRYSTPVDVWSIGTIFAELATKKPLFHGDSEIDQL 213
>Q6BNF3:STE20_DEBHA Serine/threonine-protein kinase STE20 - Debaryomyces hansenii (Yeast)| (Torulaspora hansenii) Length = 1079 Score = 75.1 bits (183), Expect = 2e-12 Identities = 67/266 (25%), Positives = 125/266 (46%), Gaps = 8/266 (3%) Frame = +3 Query: 783 IAEGGFSCVYLARDLTNPAKHYALKHVIVQDKESLDLVHKEITVMRALKGHPNVVTLVAH 962 I +G VY+A D+ + ++ A+K + ++ + +L+ EI VM+ K H N+V + Sbjct: 807 IGQGASGGVYIAHDVNHRSQTVAIKQMNLEQQPKKELIINEILVMKGSK-HENIVNFIDS 865 Query: 963 TILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAMHCQTPP 1142 +L RG + ++ME+ E ++ + T + Q+ + R+ + +H + Sbjct: 866 YLL---RG-DLWVVMEYMEGGSLTEIV---THSVMTEGQIGAVCRETLKGLRFLHSKG-- 916 Query: 1143 VAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHT---TPAYRA 1313 V HRD+K++N+LL DG K+ DFG + I E +++ T TP + A Sbjct: 917 VIHRDIKSDNILLNIDGNIKMTDFGFCAQ------------INEINLKRTTMVGTPYWMA 964 Query: 1314 PEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQIL-----NGNYRIPELPK 1478 PE + R+ KVD+W+LG ++ + + + E+ L+ L NG ++ E Sbjct: 965 PE---VVSRKEYGPKVDVWSLGIMIIEMIEGEPPYLNETPLRALYLIATNGTPKLKEPEA 1021 Query: 1479 YCSSITSLIEEMLQSSPDARPDITQV 1556 I + LQ + R + Q+ Sbjct: 1022 LSYDIRKFLSWCLQVDFNKRGNADQL 1047
>P51955:NEK2_HUMAN Serine/threonine-protein kinase Nek2 - Homo sapiens (Human)| Length = 445 Score = 75.1 bits (183), Expect = 2e-12 Identities = 70/230 (30%), Positives = 104/230 (45%), Gaps = 12/230 (5%) Frame = +3 Query: 903 EITVMRALKGHPNVVTLVAHTILDMGRGREAL-LLMEFCERSLVSALDARGTAG--FYDD 1073 E+ ++R LK HPN+V I R L ++ME+CE ++++ +GT + D+ Sbjct: 55 EVNLLRELK-HPNIVRYYDRII---DRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDE 110 Query: 1074 EQVALIFRDICNAVFAMHCQTP---PVAHRDLKAENVLLGADGAWKLCDFGSVST-NHKC 1241 E V + + A+ H ++ V HRDLK NV L KL DFG NH Sbjct: 111 EFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDT 170 Query: 1242 FDKPEERGIEEDIIRKHTTPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFD 1421 G TP Y +PE + R +EK DIW+LGCL+Y +C L F Sbjct: 171 SFAKTFVG----------TPYYMSPEQMN---RMSYNEKSDIWSLGCLLYELCALMPPFT 217 Query: 1422 GESKLQ----ILNGNY-RIPELPKYCSSITSLIEEMLQSSPDARPDITQV 1556 S+ + I G + RIP +Y + +I ML RP + ++ Sbjct: 218 AFSQKELAGKIREGKFRRIPY--RYSDELNEIITRMLNLKDYHRPSVEEI 265
>P27448:MARK3_HUMAN MAP/microtubule affinity-regulating kinase 3 - Homo sapiens (Human)| Length = 776 Score = 75.1 bits (183), Expect = 2e-12 Identities = 81/292 (27%), Positives = 132/292 (45%), Gaps = 23/292 (7%) Frame = +3 Query: 750 VGNVKVHVREAIAEGGFSCVYLARDLTNPAKHYALKHV--IVQDKESLDLVHKEITVMRA 923 +GN ++ + I +G F+ V LAR + + A+K + + SL + +E+ +M+ Sbjct: 53 IGNYRL--LKTIGKGNFAKVKLARHILT-GREVAIKIIDKTQLNPTSLQKLFREVRIMKI 109 Query: 924 LKGHPNVVTL--------VAHTILDMGRGREALLLM----EFCERSLVSALDARGTAGFY 1067 L HPN+V L + I++ G E + E+ S AG Sbjct: 110 LN-HPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQGCQAGQT 168 Query: 1068 DDEQVA-----LIFRDICNAVFAMHCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTN 1232 QV+ L+F I +AV +C + HRDLKAEN+LL AD K+ DFG Sbjct: 169 IKVQVSFDLLSLMFTFIVSAV--QYCHQKRIVHRDLKAENLLLDADMNIKIADFG----- 221 Query: 1233 HKCFDKPEERGIEEDIIRKHTTPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKS 1412 F G + D +P Y APE++ ++ +VD+W+LG ++Y + Sbjct: 222 ---FSNEFTVGGKLDTF--CGSPPYAAPELFQ--GKKYDGPEVDVWSLGVILYTLVSGSL 274 Query: 1413 AFDG----ESKLQILNGNYRIPELPKYCSSITSLIEEMLQSSPDARPDITQV 1556 FDG E + ++L G YRIP + +L++ L +P R + Q+ Sbjct: 275 PFDGQNLKELRERVLRGKYRIPFY--MSTDCENLLKRFLVLNPIKRGTLEQI 324
>Q6FN53:STE20_CANGA Serine/threonine-protein kinase STE20 - Candida glabrata (Yeast)| (Torulopsis glabrata) Length = 915 Score = 74.7 bits (182), Expect = 2e-12 Identities = 69/266 (25%), Positives = 124/266 (46%), Gaps = 8/266 (3%) Frame = +3 Query: 783 IAEGGFSCVYLARDLTNPAKHYALKHVIVQDKESLDLVHKEITVMRALKGHPNVVTLVAH 962 I +G VY+A D T A+K + ++ + +L+ EI VMR K H N+V + Sbjct: 626 IGQGASGGVYIAHD-TESEDSVAIKQMNLEKQPKKELILNEILVMRESK-HSNIVNFI-D 682 Query: 963 TILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAMHCQTPP 1142 + L G + ++ME+ E ++ + T + Q+ + R+ + +H + Sbjct: 683 SYLAKG---DLWIVMEYMEGGSLTDVV---THCLLSEGQIGAVCRETLKGLQFLHSKG-- 734 Query: 1143 VAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHT---TPAYRA 1313 V HRD+K++N+LL G KL DFG + I E+ +++ T TP + A Sbjct: 735 VLHRDIKSDNILLSLKGNIKLTDFGFCAQ------------INENNLKRTTMVGTPYWMA 782 Query: 1314 PEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQIL-----NGNYRIPELPK 1478 PE + R+ KVDIW+LG ++ + + + E+ L+ L NG ++ E Sbjct: 783 PE---VVSRKEYGPKVDIWSLGIMIIEMIEGEPPYLNETPLRALYLIATNGTPKLKEPEA 839 Query: 1479 YCSSITSLIEEMLQSSPDARPDITQV 1556 ++T ++ L+ P R T++ Sbjct: 840 LSDTLTKFLDWCLKVDPSERATATEL 865
>O60285:NUAK1_HUMAN NUAK family SNF1-like kinase 1 - Homo sapiens (Human)| Length = 661 Score = 74.7 bits (182), Expect = 2e-12 Identities = 68/234 (29%), Positives = 107/234 (45%), Gaps = 7/234 (2%) Frame = +3 Query: 876 KESLDLVH--KEITVMRALKGHPNVVTLVAHTILDMGRGREAL-LLMEFCERSLVSALDA 1046 K+ D+VH +EI +M +L HP++++ I ++ ++ + ++ME+ + D Sbjct: 92 KDEQDMVHIRREIEIMSSLN-HPHIIS-----IYEVFENKDKIVIIMEYASKG--ELYDY 143 Query: 1047 RGTAGFYDDEQVALIFRDICNAVFAMHCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVS 1226 + + FR I +AV +C V HRDLK EN+LL + K+ DFG + Sbjct: 144 ISERRRLSERETRHFFRQIVSAVH--YCHKNGVVHRDLKLENILLDDNCNIKIADFGLSN 201 Query: 1227 TNHKCFDKPEERGIEEDIIRKHTTPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYL 1406 K ++ + +P Y +PE+ + R +VD WALG L+Y + Y Sbjct: 202 LYQK----------DKFLQTFCGSPLYASPEI--VNGRPYRGPEVDSWALGVLLYTLVYG 249 Query: 1407 KSAFDGESK----LQILNGNYRIPELPKYCSSITSLIEEMLQSSPDARPDITQV 1556 FDG QI +G YR P P S LI ML +PD R I + Sbjct: 250 TMPFDGFDHKNLIRQISSGEYREPTQP---SDARGLIRWMLMVNPDRRATIEDI 300
>Q86SG6:NEK8_HUMAN Serine/threonine-protein kinase Nek8 - Homo sapiens (Human)| Length = 692 Score = 74.7 bits (182), Expect = 2e-12 Identities = 66/270 (24%), Positives = 118/270 (43%), Gaps = 12/270 (4%) Frame = +3 Query: 783 IAEGGFSCVYLARDLTNPAKHYALKHVIVQD--KESLDLVHKEITVMRALKGHPNVVTLV 956 + G F V+L + K +K + V+ KE E V++ L HPNV+ Sbjct: 10 VGRGAFGIVHLCLRKADQ-KLVIIKQIPVEQMTKEERQAAQNECQVLKLLN-HPNVIEYY 67 Query: 957 AHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAMHCQT 1136 + + D + ++ ME+ ++ + ++E + F I A+ +H T Sbjct: 68 ENFLED----KALMIAMEYAPGGTLAEFIQKRCNSLLEEETILHFFVQILLALHHVH--T 121 Query: 1137 PPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHT------T 1298 + HRDLK +N+LL H+ K + GI + + K T Sbjct: 122 HLILHRDLKTQNILLD---------------KHRMVVKIGDFGISKILSSKSKAYTVVGT 166 Query: 1299 PAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGES----KLQILNGNYRIP 1466 P Y +PE+ + + ++K DIWALGC++Y + LK AF+ + L+I++G + P Sbjct: 167 PCYISPELCE---GKPYNQKSDIWALGCVLYELASLKRAFEAANLPALVLKIMSGTF-AP 222 Query: 1467 ELPKYCSSITSLIEEMLQSSPDARPDITQV 1556 +Y + L+ +L P RP ++ + Sbjct: 223 ISDRYSPELRQLVLSLLSLEPAQRPPLSHI 252
>Q64261:CDK6_MOUSE Cell division protein kinase 6 - Mus musculus (Mouse)| Length = 326 Score = 74.7 bits (182), Expect = 2e-12 Identities = 71/237 (29%), Positives = 106/237 (44%), Gaps = 6/237 (2%) Frame = +3 Query: 783 IAEGGFSCVYLARDLTNPAKHYALKHVIVQDKES---LDLVHKEITVMRALKG--HPNVV 947 I EG + V+ ARDL N + ALK V VQ E L + +E+ V+R L+ HPNVV Sbjct: 19 IGEGAYGKVFKARDLKNGGRFVALKRVRVQTSEEGMPLSTI-REVAVLRHLETFEHPNVV 77 Query: 948 TLV-AHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAM 1124 L T+ R + L+ E ++ L + LD G + ++F+ + F + Sbjct: 78 RLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDF-L 136 Query: 1125 HCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHTTPA 1304 H V HRDLK +N+L+ + G KL DFG + + T Sbjct: 137 HSHR--VVHRDLKPQNILVTSSGQIKLADFGLARI----------YSFQMALTSVVVTLW 184 Query: 1305 YRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQILNGNYRIPELP 1475 YRAPE + + + VD+W++GC+ + K F G S + L I LP Sbjct: 185 YRAPE---VLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDIIGLP 238
>Q00646:CDC2_EMENI Cell division control protein 2 - Emericella nidulans (Aspergillus| nidulans) Length = 323 Score = 74.7 bits (182), Expect = 2e-12 Identities = 72/254 (28%), Positives = 116/254 (45%), Gaps = 21/254 (8%) Frame = +3 Query: 777 EAIAEGGFSCVYLARDLTNPAKHYALKHVIVQ--DKESLDLVHKEITVMRALKGHPNVVT 950 E I EG + VY AR+LT+P + ALK + ++ D+ +EI++++ + PN+V Sbjct: 8 EKIGEGTYGVVYKARELTHPNRIVALKKIRLEAEDEGVPSTAIREISLLKEMND-PNIVR 66 Query: 951 LVAHTILDMGRGREALLLMEFCERSLVSALDA-------RGTA-----------GFYDDE 1076 L+ D G + L+ EF + L ++A RG A G D Sbjct: 67 LLNIVHAD---GHKLYLVFEFLDLDLKKYMEALPVSEGGRGRALPDGSTLSRNLGLGD-- 121 Query: 1077 QVALIFRDICNAVFAMH-CQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKP 1253 A++ + + + + C + V HRDLK +N+L+ DG KL DFG + F P Sbjct: 122 --AMVKKFMAQLIEGIRFCHSHRVLHRDLKPQNLLIDRDGNLKLADFGLA----RAFGVP 175 Query: 1254 EERGIEEDIIRKHTTPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESK 1433 E + T YR+PE+ L S VD+W+ G + +C K F G+S+ Sbjct: 176 LRTYTHEVV-----TLWYRSPEI--LLGGRQYSTGVDMWSCGAIFAEMCTRKPLFPGDSE 228 Query: 1434 LQILNGNYRIPELP 1475 + + +RI P Sbjct: 229 IDEIFKIFRILGTP 242
>Q07785:CDC2H_PLAFK Cell division control protein 2 homolog - Plasmodium falciparum| (isolate K1 / Thailand) Length = 288 Score = 74.7 bits (182), Expect = 2e-12 Identities = 73/261 (27%), Positives = 116/261 (44%), Gaps = 16/261 (6%) Frame = +3 Query: 762 KVHVREAIAEGGFSCVYLARDLTNPAKHYALKHVIVQ--DKESLDLVHKEITVMRALKGH 935 K H E I EG + VY A++ N + +ALK + ++ D+ +EI++++ LK H Sbjct: 3 KYHGLEKIGEGTYGVVYKAQN--NYGETFALKKIRLEKEDEGIPSTTIREISILKELK-H 59 Query: 936 PNVVTL--VAHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICN 1109 N+V L V HT + +L+ E ++ L LD G + + N Sbjct: 60 SNIVKLYDVIHT------KKRLVLVFEHLDQDLKKLLDV--CEGGLESVTAKSFLLQLLN 111 Query: 1110 AVFAMHCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRK 1289 + +C V HRDLK +N+L+ +G K+ DFG + F P + E + Sbjct: 112 GI--AYCHDRRVLHRDLKPQNLLINREGELKIADFGLA----RAFGIPVRKYTHEVV--- 162 Query: 1290 HTTPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQILNGNYRI-- 1463 T YRAP++ L + S +DIW++GC+ + F G S+ L +RI Sbjct: 163 --TLWYRAPDV--LMGSKKYSTTIDIWSVGCIFAEMVNGTPLFPGVSEADQLMRIFRILG 218 Query: 1464 ----------PELPKYCSSIT 1496 ELPKY + T Sbjct: 219 TPNSKNWPNVTELPKYDPNFT 239
>P61075:CDC2H_PLAF7 Cell division control protein 2 homolog - Plasmodium falciparum| (isolate 3D7) Length = 288 Score = 74.7 bits (182), Expect = 2e-12 Identities = 73/261 (27%), Positives = 116/261 (44%), Gaps = 16/261 (6%) Frame = +3 Query: 762 KVHVREAIAEGGFSCVYLARDLTNPAKHYALKHVIVQ--DKESLDLVHKEITVMRALKGH 935 K H E I EG + VY A++ N + +ALK + ++ D+ +EI++++ LK H Sbjct: 3 KYHGLEKIGEGTYGVVYKAQN--NYGETFALKKIRLEKEDEGIPSTTIREISILKELK-H 59 Query: 936 PNVVTL--VAHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICN 1109 N+V L V HT + +L+ E ++ L LD G + + N Sbjct: 60 SNIVKLYDVIHT------KKRLVLVFEHLDQDLKKLLDV--CEGGLESVTAKSFLLQLLN 111 Query: 1110 AVFAMHCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRK 1289 + +C V HRDLK +N+L+ +G K+ DFG + F P + E + Sbjct: 112 GI--AYCHDRRVLHRDLKPQNLLINREGELKIADFGLA----RAFGIPVRKYTHEVV--- 162 Query: 1290 HTTPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQILNGNYRI-- 1463 T YRAP++ L + S +DIW++GC+ + F G S+ L +RI Sbjct: 163 --TLWYRAPDV--LMGSKKYSTTIDIWSVGCIFAEMVNGTPLFPGVSEADQLMRIFRILG 218 Query: 1464 ----------PELPKYCSSIT 1496 ELPKY + T Sbjct: 219 TPNSKNWPNVTELPKYDPNFT 239
>Q9P286:PAK7_HUMAN Serine/threonine-protein kinase PAK 7 - Homo sapiens (Human)| Length = 719 Score = 74.3 bits (181), Expect = 3e-12 Identities = 70/257 (27%), Positives = 122/257 (47%), Gaps = 5/257 (1%) Frame = +3 Query: 783 IAEGGFSCVYLARDLTNPAKHYALKHVIVQDKESLDLVHKEITVMRALKGHPNVVTLVAH 962 I EG V +A + + K A+K + ++ ++ +L+ E+ +MR H NVV + + Sbjct: 455 IGEGSTGIVCIATE-KHTGKQVAVKKMDLRKQQRRELLFNEVVIMRDYH-HDNVVDMYSS 512 Query: 963 TILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAMHCQTPP 1142 ++ G E ++MEF E AL T ++EQ+A + + A+ +H Q Sbjct: 513 YLV----GDELWVVMEFLEGG---ALTDIVTHTRMNEEQIATVCLSVLRALSYLHNQG-- 563 Query: 1143 VAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHTTPAYRAPEM 1322 V HRD+K++++LL +DG KL DFG + K + P+ + + TP + APE Sbjct: 564 VIHRDIKSDSILLTSDGRIKLSDFGFCAQVSK--EVPKRKSLV-------GTPYWMAPE- 613 Query: 1323 WDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQILNG-----NYRIPELPKYCS 1487 + R +VDIW+LG ++ + + + E LQ + R+ +L K S Sbjct: 614 --VISRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLPPRVKDLHKVSS 671 Query: 1488 SITSLIEEMLQSSPDAR 1538 + ++ ML P R Sbjct: 672 VLRGFLDLMLVREPSQR 688
>P51957:NEK4_HUMAN Serine/threonine-protein kinase Nek4 - Homo sapiens (Human)| Length = 841 Score = 74.3 bits (181), Expect = 3e-12 Identities = 74/269 (27%), Positives = 118/269 (43%), Gaps = 11/269 (4%) Frame = +3 Query: 783 IAEGGFSCVYLARDLTNPAKHYALKHVIVQDKESLD--LVHKEITVMRALKGHPNVVTLV 956 + +G + V L + + K Y +K + +++ S + +E ++ LK HPN+VT Sbjct: 12 VGKGSYGEVTLVKHRRD-GKQYVIKKLNLRNASSRERRAAEQEAQLLSQLK-HPNIVTYK 69 Query: 957 AHTILDMGRGREALL--LMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAMHC 1130 + G + LL +M FCE + + QV F I A+ +H Sbjct: 70 -----ESWEGGDGLLYIVMGFCEGGDLYRKLKEQKGQLLPENQVVEWFVQIAMALQYLH- 123 Query: 1131 QTPPVAHRDLKAENVLLGADGAWKLCDFG--SVSTNHKCFDKPEERGIEEDIIRKHTTPA 1304 + HRDLK +NV L K+ D G V NH C G TP Sbjct: 124 -EKHILHRDLKTQNVFLTRTNIIKVGDLGIARVLENH-CDMASTLIG----------TPY 171 Query: 1305 YRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESK----LQILNGNYRIPEL 1472 Y +PE L+ + + K D+WALGC +Y + LK AF+ + +I+ G ++P + Sbjct: 172 YMSPE---LFSNKPYNYKSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIIEG--KLPAM 226 Query: 1473 PK-YCSSITSLIEEMLQSSPDARPDITQV 1556 P+ Y + LI ML P+ RP + + Sbjct: 227 PRDYSPELAELIRTMLSKRPEERPSVRSI 255
>O15865:CDPK2_PLAFK Calcium-dependent protein kinase 2 - Plasmodium falciparum (isolate| K1 / Thailand) Length = 513 Score = 74.3 bits (181), Expect = 3e-12 Identities = 78/275 (28%), Positives = 124/275 (45%), Gaps = 11/275 (4%) Frame = +3 Query: 762 KVHVREAIAEGGFSCVYLARD-LTNPAKHYALKHVIVQDKESLDLVHKEITVMRALKGHP 938 K + E + +G + CVY D +TN YA+K ++++ +EI +M+ L HP Sbjct: 71 KYIIDEKLGQGTYGCVYKGIDKVTNQL--YAIKEEKKDRLKNINRFFQEIEIMKKLD-HP 127 Query: 939 NVVTLVAHTILDMGRGREALLLMEFCE-RSLVSALDARGTAGFYDDEQVALIFRDICNAV 1115 N+V L D L+ME C R L ++ G+ + ++ A I + I +A+ Sbjct: 128 NIVKLYETYEND----NYIYLIMELCSGRELFDSIIENGS---FTEKNAATIMKQIFSAI 180 Query: 1116 FAMHCQTPPVAHRDLKAENVLLGA---DGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIR 1286 F +H + HRDLK EN L + D K+ DFG +S N G E Sbjct: 181 FYLHSLN--IVHRDLKPENFLFQSENKDSLLKIIDFG-LSKN---------LGTGEFTTT 228 Query: 1287 KHTTPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQIL----NGN 1454 K TP Y AP++ D +K DIW+ G +MY + F G++ ++L G Sbjct: 229 KAGTPYYVAPQVLD----GKYDKKCDIWSSGVIMYTLLCGYPPFYGDTDNEVLKKVKKGE 284 Query: 1455 YRIPE--LPKYCSSITSLIEEMLQSSPDARPDITQ 1553 + E S +LI ++L +P+ R I + Sbjct: 285 FCFYENDWGSISSDAKNLITKLLTYNPNERCTIEE 319
>Q8ICR0:CDPK2_PLAF7 Calcium-dependent protein kinase 2 - Plasmodium falciparum (isolate| 3D7) Length = 509 Score = 74.3 bits (181), Expect = 3e-12 Identities = 78/275 (28%), Positives = 124/275 (45%), Gaps = 11/275 (4%) Frame = +3 Query: 762 KVHVREAIAEGGFSCVYLARD-LTNPAKHYALKHVIVQDKESLDLVHKEITVMRALKGHP 938 K + E + +G + CVY D +TN YA+K ++++ +EI +M+ L HP Sbjct: 71 KYIIDEKLGQGTYGCVYKGIDKVTNQL--YAIKEEKKDRLKNINRFFQEIEIMKKLD-HP 127 Query: 939 NVVTLVAHTILDMGRGREALLLMEFCE-RSLVSALDARGTAGFYDDEQVALIFRDICNAV 1115 N+V L D L+ME C R L ++ G+ + ++ A I + I +A+ Sbjct: 128 NIVKLYETYEND----NYIYLIMELCSGRELFDSIIENGS---FTEKNAATIMKQIFSAI 180 Query: 1116 FAMHCQTPPVAHRDLKAENVLLGA---DGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIR 1286 F +H + HRDLK EN L + D K+ DFG +S N G E Sbjct: 181 FYLHSLN--IVHRDLKPENFLFQSENKDSLLKIIDFG-LSKN---------LGTGEFTTT 228 Query: 1287 KHTTPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQIL----NGN 1454 K TP Y AP++ D +K DIW+ G +MY + F G++ ++L G Sbjct: 229 KAGTPYYVAPQVLD----GKYDKKCDIWSSGVIMYTLLCGYPPFYGDTDNEVLKKVKKGE 284 Query: 1455 YRIPE--LPKYCSSITSLIEEMLQSSPDARPDITQ 1553 + E S +LI ++L +P+ R I + Sbjct: 285 FCFYENDWGSISSDAKNLITKLLTYNPNERCTIEE 319
>Q7YRC6:AURKB_BOVIN Serine/threonine-protein kinase 12 - Bos taurus (Bovine)| Length = 344 Score = 74.3 bits (181), Expect = 3e-12 Identities = 82/320 (25%), Positives = 140/320 (43%), Gaps = 19/320 (5%) Frame = +3 Query: 705 EHSGPSGGLEGRTIDVGNVKVHVREAIAEGGFSCVYLARDLTNPAKHY--ALKHVIVQDK 878 E+S + + R+ + + ++ + +G F VYLAR+ + H+ ALK + Sbjct: 59 ENSSGTPNIPKRSFTIDDFEIG--RPLGKGKFGNVYLAREKKS---HFIVALKVLFKSQI 113 Query: 879 ESLDLVH---KEITVMRALKGHPNVVTLVAHTILDMGRGREALLLMEFCERS-LVSALDA 1046 E + H +EI + L+ HPN++ L + R L++E+ R L L Sbjct: 114 EKEGVEHQLRREIEIQAHLQ-HPNILRLYNYFY----DRRRIYLILEYAPRGELYKELQK 168 Query: 1047 RGTAGFYDDEQVALIFRDICNAVFAMHCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVS 1226 T +D+++ A I ++ +A+ +C V HRD+K EN+LLG G K+ DFG Sbjct: 169 SRT---FDEQRTATIMEELADAL--TYCHAKKVIHRDIKPENLLLGLRGELKIADFG--- 220 Query: 1227 TNHKCFDKPEERGIEEDIIRKHT---TPAYRAPEMWDLYRREVISEKVDIWALGCLMYRI 1397 + +R+ T T Y PEM +EKVD+W +G L Y + Sbjct: 221 -----------WSVHAPSLRRKTMCGTLDYLPPEM---IEGRTHNEKVDLWCIGVLCYEL 266 Query: 1398 CY----LKSAFDGESKLQILNGNYRIPELPKYCSSITSLIEEMLQSSPDARPDITQV--- 1556 +SA E+ +I+ + + P P I ++L+ +P R + QV Sbjct: 267 LVGNPPFESASHNETYRRIVKVDLKFP--PSVPLGAQDFIYKLLKHNPSERLPLAQVSAH 324 Query: 1557 -WFRVN--ELLPLELQKDLP 1607 W R + +LP + +P Sbjct: 325 PWVRTHSRRVLPPSAPQSVP 344
>Q17850:PAK1_CAEEL Serine/threonine-protein kinase pak-1 - Caenorhabditis elegans| Length = 572 Score = 73.9 bits (180), Expect = 4e-12 Identities = 74/269 (27%), Positives = 132/269 (49%), Gaps = 8/269 (2%) Frame = +3 Query: 744 IDVGNVKVHVREA--IAEGGFSCVYLARDLTNPAKHYALKHVIVQDKESLDLVHKEITVM 917 + +GN R+ I G VY A +++ A+ A+K + ++D+ +L+ EI VM Sbjct: 286 VSIGNPDRKYRKVDKIGSGASGSVYTAIEISTEAE-VAIKQMNLKDQPKKELIINEILVM 344 Query: 918 RALKGHPNVVT-LVAHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIF 1094 R K H N+V L ++ + D E ++ME+ ++ + T +D +A + Sbjct: 345 RENK-HANIVNYLDSYLVCD-----ELWVVMEYLAGGSLTDVV---TECQMEDGIIAAVC 395 Query: 1095 RDICNAVFAMHCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEE 1274 R++ A+ +H + V HRD+K++N+LLG DG+ KL DFG + PE+R Sbjct: 396 REVLQALEFLHSRH--VIHRDIKSDNILLGMDGSVKLTDFGFCAQL-----SPEQRKRTT 448 Query: 1275 DIIRKHTTPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQIL--- 1445 + TP + APE + R+ KVD+W+LG + + + + E+ L+ + Sbjct: 449 MV----GTPYWMAPE---VVTRKQYGPKVDVWSLGIMAIEMVEGEPPYLNENPLRAIYLI 501 Query: 1446 --NGNYRIPELPKYCSSITSLIEEMLQSS 1526 NG P+ P S+T L ++ + S+ Sbjct: 502 ATNGK---PDFPGR-DSMTLLFKDFVDSA 526
>P59895:NEK6_RAT Serine/threonine-protein kinase Nek6 - Rattus norvegicus (Rat)| Length = 313 Score = 73.9 bits (180), Expect = 4e-12 Identities = 79/277 (28%), Positives = 121/277 (43%), Gaps = 15/277 (5%) Frame = +3 Query: 771 VREAIAEGGFSCVYLARDLTNPAKHYALKHVIV---QDKESLDLVHKEITVMRALKGHPN 941 + + I G FS VY A L + K ALK V + D ++ KEI +++ L HPN Sbjct: 47 IEKKIGRGQFSEVYKATCLLD-RKTVALKKVQIFEMMDAKARQDCVKEIGLLKQLN-HPN 104 Query: 942 VVTLVAHTILDMGRGREALLLMEFCERSLVSALDA--RGTAGFYDDEQVALIFRDICNAV 1115 ++ + I D E +++E + +S + + + V F +C+AV Sbjct: 105 IIKYLDSFIED----NELNIVLELADAGDLSQMIKYFKKQKRLIPERTVWKYFVQLCSAV 160 Query: 1116 FAMHCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHT 1295 MH + V HRD+K NV + A G KL D G R + H+ Sbjct: 161 EHMHSRR--VMHRDIKPANVFITATGIVKLGDLGL------------GRFFSSETTAAHS 206 Query: 1296 ---TPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQILNGNYRI- 1463 TP Y +PE + K DIW+LGCL+Y + L+S F G+ K+ + + +I Sbjct: 207 LVGTPYYMSPER---IHENGYNFKSDIWSLGCLLYEMAALQSPFYGD-KMNLFSLCQKIE 262 Query: 1464 ----PELP--KYCSSITSLIEEMLQSSPDARPDITQV 1556 P LP Y + L+ + P+ RPDI V Sbjct: 263 QCDYPPLPGEHYSEKLRELVSMCIYPDPNHRPDIEYV 299
>Q00534:CDK6_HUMAN Cell division protein kinase 6 - Homo sapiens (Human)| Length = 326 Score = 73.9 bits (180), Expect = 4e-12 Identities = 70/236 (29%), Positives = 107/236 (45%), Gaps = 5/236 (2%) Frame = +3 Query: 783 IAEGGFSCVYLARDLTNPAKHYALKHVIVQD-KESLDL-VHKEITVMRALKG--HPNVVT 950 I EG + V+ ARDL N + ALK V VQ +E + L +E+ V+R L+ HPNVV Sbjct: 19 IGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVR 78 Query: 951 LV-AHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAMH 1127 L T+ R + L+ E ++ L + LD G + ++F+ + F +H Sbjct: 79 LFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDF-LH 137 Query: 1128 CQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHTTPAY 1307 V HRDLK +N+L+ + G KL DFG + + T Y Sbjct: 138 SHR--VVHRDLKPQNILVTSSGQIKLADFGLARI----------YSFQMALTSVVVTLWY 185 Query: 1308 RAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQILNGNYRIPELP 1475 RAPE + + + VD+W++GC+ + K F G S + L + LP Sbjct: 186 RAPE---VLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLP 238
>Q03497:STE20_YEAST Serine/threonine-protein kinase STE20 - Saccharomyces cerevisiae| (Baker's yeast) Length = 939 Score = 73.6 bits (179), Expect = 5e-12 Identities = 69/267 (25%), Positives = 127/267 (47%), Gaps = 9/267 (3%) Frame = +3 Query: 783 IAEGGFSCVYLARDL-TNPAKHYALKHVIVQDKESLDLVHKEITVMRALKGHPNVVTLVA 959 I +G VY A ++ TN + A+K + ++ + +L+ EI VM+ K HPN+V + Sbjct: 626 IGQGASGGVYTAYEIGTNVS--VAIKQMNLEKQPKKELIINEILVMKGSK-HPNIVNFID 682 Query: 960 HTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAMHCQTP 1139 +L + ++ME+ E ++ + T + Q+ + R+ + + +H + Sbjct: 683 SYVLK----GDLWVIMEYMEGGSLTDVV---THCILTEGQIGAVCRETLSGLEFLHSKG- 734 Query: 1140 PVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHT---TPAYR 1310 V HRD+K++N+LL +G KL DFG + I E +++ T TP + Sbjct: 735 -VLHRDIKSDNILLSMEGDIKLTDFGFCAQ------------INELNLKRTTMVGTPYWM 781 Query: 1311 APEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQIL-----NGNYRIPELP 1475 APE + R+ KVDIW+LG ++ + + + E+ L+ L NG ++ E Sbjct: 782 APE---VVSRKEYGPKVDIWSLGIMIIEMIEGEPPYLNETPLRALYLIATNGTPKLKEPE 838 Query: 1476 KYCSSITSLIEEMLQSSPDARPDITQV 1556 SS+ ++ L P+ R T++ Sbjct: 839 NLSSSLKKFLDWCLCVEPEDRASATEL 865
>Q9UU87:PPK34_SCHPO Serine/threonine-protein kinase ppk34 - Schizosaccharomyces pombe| (Fission yeast) Length = 354 Score = 73.6 bits (179), Expect = 5e-12 Identities = 59/232 (25%), Positives = 113/232 (48%), Gaps = 3/232 (1%) Frame = +3 Query: 870 QDKESLDLVHKEITVMRALKGHPNVVTLVAHTILDMGRGREALLLMEFCERSLVSALDAR 1049 + K+ + KE+ V++ L H NVV L + +++ +++ +C ++++D Sbjct: 110 EKKDPYYYIRKELDVLKVLD-HENVVKL--YQVINSDYKDSLCMVLNYCPGGKLASVDHG 166 Query: 1050 GTAGFYDDEQVALIFRDICNAVFAMHCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVST 1229 + E FR + AV +H + V HRD+K +N+L + + DFG Sbjct: 167 ISFDPMPLETCRKSFRQLVLAVNYIHGKG--VIHRDIKPDNILFKENNNLCVIDFGLAEF 224 Query: 1230 NHKC-FDKPEERGIEEDIIRKHTTPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYL 1406 K F KP TPA+ APE++D +++ + +DIW++G +Y I + Sbjct: 225 LPKDGFVKPASG-----------TPAFMAPELFDNELKKIKGKPLDIWSMGVTLYVIAFA 273 Query: 1407 KSAFDGESKLQILNG-NYRIPELPKYCSS-ITSLIEEMLQSSPDARPDITQV 1556 + F+G + L ++N + +P YC+S + L+E L+ +P+ R I ++ Sbjct: 274 EFPFNGSTILDMINVIKGKSLMIPAYCNSDLRKLLERCLEKNPEKRITIEEL 325
>Q8C015:PAK7_MOUSE Serine/threonine-protein kinase PAK 7 - Mus musculus (Mouse)| Length = 719 Score = 73.6 bits (179), Expect = 5e-12 Identities = 70/257 (27%), Positives = 121/257 (47%), Gaps = 5/257 (1%) Frame = +3 Query: 783 IAEGGFSCVYLARDLTNPAKHYALKHVIVQDKESLDLVHKEITVMRALKGHPNVVTLVAH 962 I EG V +A + + K A+K + ++ ++ +L+ E+ +MR H NVV + Sbjct: 455 IGEGSTGIVCIATE-KHTGKQVAVKKMDLRKQQRRELLFNEVVIMRDYH-HDNVVDMYNS 512 Query: 963 TILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAMHCQTPP 1142 ++ G E ++MEF E AL T ++EQ+A + + A+ +H Q Sbjct: 513 YLV----GDELWVVMEFLEGG---ALTDIVTHTRMNEEQIATVCLSVLKALSYLHNQG-- 563 Query: 1143 VAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHTTPAYRAPEM 1322 V HRD+K++++LL +DG KL DFG + K + P+ + + TP + APE Sbjct: 564 VIHRDIKSDSILLTSDGRIKLSDFGFCAQVSK--EVPKRKSLV-------GTPYWMAPE- 613 Query: 1323 WDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQILNG-----NYRIPELPKYCS 1487 + R +VDIW+LG ++ + + + E LQ + R+ +L K S Sbjct: 614 --VISRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLPPRVKDLHKVSS 671 Query: 1488 SITSLIEEMLQSSPDAR 1538 + ++ ML P R Sbjct: 672 MLRGFLDLMLVREPSQR 688
>Q9WVS4:MOK_MOUSE MAPK/MAK/MRK overlapping kinase - Mus musculus (Mouse)| Length = 420 Score = 73.6 bits (179), Expect = 5e-12 Identities = 66/220 (30%), Positives = 107/220 (48%), Gaps = 2/220 (0%) Frame = +3 Query: 783 IAEGGFSCVYLARDLTNPAKHYALKHVIVQDKESLDLVH--KEITVMRALKGHPNVVTLV 956 I EG FS V + L + +YA K + Q ES++ V+ +EI +R L HPN++ L Sbjct: 10 IGEGTFSEVMKMQSLRD-GNYYACKQM-KQHFESIEQVNSLREIQALRRLNPHPNILAL- 66 Query: 957 AHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAMHCQT 1136 H ++ + L+ E + ++ + RG ++++ L +C ++ MH Sbjct: 67 -HEVVFDRKSGSLALICELMDMNIYELI--RGRRHPLSEKKIMLYMYQLCKSLDHMHRNG 123 Query: 1137 PPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHTTPAYRAP 1316 + HRD+K EN+L+ D KL DFGS C ++ E I +T YRAP Sbjct: 124 --IFHRDVKPENILVKQD-VLKLGDFGS------CRSVYSKQPYTEYI----STRWYRAP 170 Query: 1317 EMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKL 1436 E L + K+D+W+ GC+ Y I L+ F G ++L Sbjct: 171 EC--LLTDGFYTYKMDLWSAGCVFYEIASLQPLFPGVNEL 208
>Q12469:SKM1_YEAST Serine/threonine-protein kinase SKM1 - Saccharomyces cerevisiae| (Baker's yeast) Length = 655 Score = 73.2 bits (178), Expect = 6e-12 Identities = 66/288 (22%), Positives = 128/288 (44%), Gaps = 28/288 (9%) Frame = +3 Query: 777 EAIAEGGFSCVYLARDLTNPAKH----------------YALKHVIVQDKESLDLVHKEI 908 E +G VYL++ + P ++ A+K + + ++ L+ E+ Sbjct: 364 EKAGQGASGAVYLSKRIKLPQENDPRFLKSHCHRVVGERVAIKQIRLSEQPKKQLIMNEL 423 Query: 909 TVMRALKGHPNVVTLVAHTILDMGRGREALLLMEFCERS-LVSALDA--RGTAGFY---- 1067 VM + N+V + I+D E ++ME+ E L LDA R G + Sbjct: 424 LVMNDSR-QENIVNFLEAYIID---DEELWVIMEYMEGGCLTDILDAVARSNTGEHSSPL 479 Query: 1068 DDEQVALIFRDICNAVFAMHCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFD 1247 ++ Q+A I ++ C + +H + HRD+K++N+LL + G K+ DFG C + Sbjct: 480 NENQMAYIVKETCQGLKFLH--NKKIIHRDIKSDNILLNSQGLVKITDFGF------CVE 531 Query: 1248 KPEERGIEEDIIRKHTTPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGE 1427 E+R ++ TP + APE + ++ EKVD+W+LG ++ + + + E Sbjct: 532 LTEKRSKRATMV---GTPYWMAPE---IVNQKGYDEKVDVWSLGIMLIEMIEGEPPYLNE 585 Query: 1428 SKLQIL-----NGNYRIPELPKYCSSITSLIEEMLQSSPDARPDITQV 1556 L+ L NG+ ++ ++ LQ + ++R + ++ Sbjct: 586 DPLKALYLIANNGSPKLRHPESVSKQTKQFLDACLQVNVESRASVRKL 633
>Q3UGM2:NEK10_MOUSE Serine/threonine-protein kinase Nek10 - Mus musculus (Mouse)| Length = 1111 Score = 73.2 bits (178), Expect = 6e-12 Identities = 72/286 (25%), Positives = 120/286 (41%), Gaps = 16/286 (5%) Frame = +3 Query: 771 VREAIAEGGFSCVYLARDLTNPAKHYALKHVIV------QDKESLDLVHK----EITVMR 920 V + + G F CVY R + A+K V + +DK+ D K E+T+++ Sbjct: 521 VLDHLGSGAFGCVYKVRKRSGQ-NLLAMKEVNLHNPAFGKDKKDRDSSVKNIVSELTIIK 579 Query: 921 ALKGHPNVVTLVAHTILDMGRGREALLLMEFCERSLVSAL--DARGTAGFYDDEQVALIF 1094 HPNVV T L+ R ++ME E + + + + +E++ IF Sbjct: 580 EQLYHPNVVRYYK-TFLENDR---LYIVMELIEGAPLGEHFNSLKEKHHHFSEERLWKIF 635 Query: 1095 RDICNAVFAMHCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEE 1274 +C A+ +H + + HRDL N++LG + DFG + G Sbjct: 636 IQLCLALRYLH-KEKRIVHRDLTPNNIMLGDKDKVTVTDFGLAKQKQESSKLTSMVG--- 691 Query: 1275 DIIRKHTTPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKL----QI 1442 T Y PE+ + E EK D+WA GC++Y++ L F + L +I Sbjct: 692 -------TILYSCPEV---LKSEPYGEKADVWAAGCILYQMATLSPPFCSTNMLSLATKI 741 Query: 1443 LNGNYRIPELPKYCSSITSLIEEMLQSSPDARPDITQVWFRVNELL 1580 + Y Y +T I L +ARPDI +V +++++ Sbjct: 742 VEAVYEPVPEGIYSEKVTDTIRRCLTPDAEARPDIVEVSSMISDVM 787
>Q09170:CDS1_SCHPO Serine/threonine-protein kinase cds1 - Schizosaccharomyces pombe| (Fission yeast) Length = 460 Score = 73.2 bits (178), Expect = 6e-12 Identities = 81/300 (27%), Positives = 131/300 (43%), Gaps = 19/300 (6%) Frame = +3 Query: 696 MPKEHSGPSGGLEGRTIDVGNVKVHVREAIAEGGFSCVYLARDLTNPAKHYALKHV---- 863 +P +HS S + I N + + G F+ V LA ++ N K YA+K + Sbjct: 147 VPVKHSRDS---QKNMIKSENSHYEIIRTLGSGTFAVVKLAVEV-NSGKWYAIKIINKRK 202 Query: 864 ---IVQDKESLDLVHKEITVMRALKGHPNVVTLVAHTILDMGRGREALLLMEFCERS-LV 1031 +K + ++ +EI ++++L HP VV H I + E ++ME+ E L+ Sbjct: 203 ILLTSSEKRATEMFQREIDILKSLH-HPGVVQ--CHEIFE--NDDELFIVMEYVEGGDLM 257 Query: 1032 SALDARGTAGFYDDEQVALIFRDICNAVFAMHCQTPPVAHRDLKAENVLLGADGAWKLCD 1211 L A G+ D++ + + + + +H Q V HRD+K EN+L+ D K+ D Sbjct: 258 DFLIANGSI---DEQDCKPLLKQLLETLLHLHKQG--VTHRDIKPENILITNDFHLKISD 312 Query: 1212 FGSVSTNHKCFDKPEERGIEEDIIRKHTTPAYRAPEMWDLYRREV-----ISEKVDIWAL 1376 FG H G + T Y APE+ L + V +KVDIW+L Sbjct: 313 FGLAKVIH---------GTGTFLETFCGTMGYLAPEV--LKSKNVNLDGGYDDKVDIWSL 361 Query: 1377 GCLMYRICYLKSAFDGESKLQ----ILNGNYRIPEL--PKYCSSITSLIEEMLQSSPDAR 1538 GC++Y + F S+ + I G Y I L + LI ML+ +P+ R Sbjct: 362 GCVLYVMLTASIPFASSSQAKCIELISKGAYPIEPLLENEISEEGIDLINRMLEINPEKR 421
>Q4KM47:CDK10_RAT Cell division protein kinase 10 - Rattus norvegicus (Rat)| Length = 358 Score = 73.2 bits (178), Expect = 6e-12 Identities = 66/221 (29%), Positives = 108/221 (48%), Gaps = 3/221 (1%) Frame = +3 Query: 783 IAEGGFSCVYLARDLTNPAKHYALKHVIV-QDKESLDLVH-KEITVMRALKGHPNVVTLV 956 I EG + VY ARD T + ALK V + ++K+ + + +EIT++ L+ HPN+V L Sbjct: 43 IGEGTYGIVYRARD-TQTDEIVALKKVRMDKEKDGIPISSLREITLLLRLR-HPNIVELK 100 Query: 957 AHTILDMGRGREAL-LLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAMHCQ 1133 + G E++ L+M +CE+ L S L+ T + + QV I + + +H Sbjct: 101 EVVV---GNHLESIFLVMGYCEQDLASLLENMPTP--FSEAQVKCILLQVLRGLQYLHRS 155 Query: 1134 TPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHTTPAYRA 1313 + HRDLK N+L+ G K DFG + + P + + K T YRA Sbjct: 156 F--IIHRDLKVSNLLMTDKGCVKTADFGLA----RAYGVP-----VKPMTPKVVTLWYRA 204 Query: 1314 PEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKL 1436 PE+ L + +D+WA+GC++ + K G S++ Sbjct: 205 PEL--LLGTTTQTTSIDMWAVGCILAELLAHKPLLPGTSEI 243
>Q3UMM4:CDK10_MOUSE Cell division protein kinase 10 - Mus musculus (Mouse)| Length = 360 Score = 73.2 bits (178), Expect = 6e-12 Identities = 66/221 (29%), Positives = 108/221 (48%), Gaps = 3/221 (1%) Frame = +3 Query: 783 IAEGGFSCVYLARDLTNPAKHYALKHVIV-QDKESLDLVH-KEITVMRALKGHPNVVTLV 956 I EG + VY ARD T + ALK V + ++K+ + + +EIT++ L+ HPN+V L Sbjct: 45 IGEGTYGIVYRARD-TQTDEIVALKKVRMDKEKDGIPISSLREITLLLRLR-HPNIVELK 102 Query: 957 AHTILDMGRGREAL-LLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAMHCQ 1133 + G E++ L+M +CE+ L S L+ T + + QV I + + +H Sbjct: 103 EVVV---GNHLESIFLVMGYCEQDLASLLENMPTP--FSEAQVKCIMLQVLRGLQYLHRN 157 Query: 1134 TPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHTTPAYRA 1313 + HRDLK N+L+ G K DFG + + P + + K T YRA Sbjct: 158 F--IIHRDLKVSNLLMTDKGCVKTADFGLA----RAYGVP-----VKPMTPKVVTLWYRA 206 Query: 1314 PEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKL 1436 PE+ L + +D+WA+GC++ + K G S++ Sbjct: 207 PEL--LLGTTTQTTSIDMWAVGCILAELLAHKPLLPGTSEI 245
>O96821:CDC2H_PLAKH Cell division control protein 2 homolog - Plasmodium knowlesi (strain| H) Length = 288 Score = 73.2 bits (178), Expect = 6e-12 Identities = 71/256 (27%), Positives = 115/256 (44%), Gaps = 16/256 (6%) Frame = +3 Query: 762 KVHVREAIAEGGFSCVYLARDLTNPAKHYALKHVIVQ--DKESLDLVHKEITVMRALKGH 935 K H E I EG + VY A++ N + +ALK + ++ D+ +EI++++ LK H Sbjct: 3 KYHGLEKIGEGTYGVVYKAQN--NYGETFALKKIRLEKEDEGIPSTAIREISILKELK-H 59 Query: 936 PNVVTL--VAHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICN 1109 N+V L V HT + +L+ E ++ L LD G + + + Sbjct: 60 SNIVKLYDVIHT------KKRLILVFEHLDQDLKKLLDV--CDGGLESVTAKSFLLQLLS 111 Query: 1110 AVFAMHCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRK 1289 + +C V HRDLK +N+L+ +G K+ DFG + F P + E + Sbjct: 112 GI--AYCHEHRVLHRDLKPQNLLINREGELKIADFGLA----RAFGIPVRKYTHEVV--- 162 Query: 1290 HTTPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQILNGNYRI-- 1463 T YRAP++ L + S +DIW++GC+ + + F G S+ L +RI Sbjct: 163 --TLWYRAPDI--LMGSKKYSTPIDIWSVGCIFAEMVNGRPLFPGVSETDQLMRIFRILG 218 Query: 1464 ----------PELPKY 1481 ELPKY Sbjct: 219 TPNSANWPSVTELPKY 234
>Q11179:YPC2_CAEEL Putative serine/threonine-protein kinase C05D10.2 - Caenorhabditis| elegans Length = 470 Score = 72.8 bits (177), Expect = 8e-12 Identities = 62/227 (27%), Positives = 102/227 (44%), Gaps = 2/227 (0%) Frame = +3 Query: 762 KVHVREAIAEGGFSCVYLARDLTNPAKHYALKHVIVQDKESLDL--VHKEITVMRALKGH 935 K +++ + +G + V+ A D + + ALK + + D +E+ ++ H Sbjct: 12 KFDLQKRLGKGAYGIVWKAYDKRS-RETVALKKIFDAFRNPTDSQRTFREVMFLQEFGKH 70 Query: 936 PNVVTLVAHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAV 1115 PNV+ L + I R+ L EF E L + + D I + A+ Sbjct: 71 PNVIKL--YNIFRADNDRDIYLAFEFMEADLHNVIKK---GSILKDVHKQYIMCQLFRAI 125 Query: 1116 FAMHCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHT 1295 +H V HRDLK NVLL AD KL DFG + D PE + + D+ Sbjct: 126 RFLHSGN--VLHRDLKPSNVLLDADCRVKLADFGLARSLSSLEDYPEGQKM-PDLTEYVA 182 Query: 1296 TPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKL 1436 T YR+PE+ L + ++ VD+W+LGC++ + ++ F G S + Sbjct: 183 TRWYRSPEI--LLAAKRYTKGVDMWSLGCILAEMLIGRALFPGSSTI 227
>Q91820:STK6_XENLA Serine/threonine-protein kinase 6 - Xenopus laevis (African clawed| frog) Length = 407 Score = 72.8 bits (177), Expect = 8e-12 Identities = 69/268 (25%), Positives = 117/268 (43%), Gaps = 16/268 (5%) Frame = +3 Query: 783 IAEGGFSCVYLARDLTNPAKHYALKHVIVQDKESLDLVH---KEITVMRALKGHPNVVTL 953 + +G F VYLAR+ + ALK + E + H +E+ + L+ HPN++ L Sbjct: 146 LGKGKFGNVYLARERESKFI-LALKVLFKSQLEKAGVEHQLRREVEIQSHLR-HPNILRL 203 Query: 954 VAH--------TILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICN 1109 + ILD G E ++ C R +DD++ A+ + + Sbjct: 204 YGYFHDASRVYLILDYAPGGELFRELQKCTR--------------FDDQRSAMYIKQLAE 249 Query: 1110 AVFAMHCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRK 1289 A+ ++C + V HRD+K EN+LLG++G K+ DFG + R+ Sbjct: 250 AL--LYCHSKKVIHRDIKPENLLLGSNGELKIADFG--------------WSVHAPSSRR 293 Query: 1290 HT---TPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQILNGNYR 1460 T T Y PEM + E VD+W+LG L Y K F+ ++ + + Sbjct: 294 TTLCGTLDYLPPEM---IEGRMHDETVDLWSLGVLCYEFLVGKPPFETDTHQETYRRISK 350 Query: 1461 IP-ELPKYCS-SITSLIEEMLQSSPDAR 1538 + + P Y S L+ ++L+ +P+ R Sbjct: 351 VEFQYPPYVSEEARDLVSKLLKHNPNHR 378
>Q7Z8E9:STE20_MAGGR Serine/threonine-protein kinase MST20 - Magnaporthe grisea (Rice| blast fungus) (Pyricularia grisea) Length = 914 Score = 72.8 bits (177), Expect = 8e-12 Identities = 77/298 (25%), Positives = 127/298 (42%), Gaps = 12/298 (4%) Frame = +3 Query: 681 PFRQLMPKEHSGPSGGLE-----GRTIDVGNVKVHVRE--AIAEGGFSCVYLARDLTNPA 839 P Q P+ S S GL+ R G+ + R I +G VY + Sbjct: 599 PVPQSRPRHRSRQSNGLDVVAALKRICSEGDPREIYRSFTKIGQGASGGVYTGHE-RGSN 657 Query: 840 KHYALKHVIVQDKESLDLVHKEITVMRALKGHPNVVTLVAHTILDMGRGREALLLMEFCE 1019 + A+K + ++ + DL+ EI VM+ HPN+V + + G E ++MEF E Sbjct: 658 RLVAIKQMNLEQQPKKDLIINEILVMKD-SSHPNIVNFIDSYLC----GGELWVVMEFME 712 Query: 1020 RSLVSALDARGTAGFYDDEQVALIFRDICNAVFAMHCQTPPVAHRDLKAENVLLGADGAW 1199 ++ + T + Q+A + R+ + H + V HRD+K++N+LL +G Sbjct: 713 GGSLTDVV---TFNIMTEGQIASVCRETLLGL--QHLHSKGVIHRDIKSDNILLSMEGNI 767 Query: 1200 KLCDFGSVSTNHKCFDKPEERGIEEDIIRKHTTPAYRAPEMWDLYRREVISEKVDIWALG 1379 KL DFG +T ++ +K TP + APE + R+ KVDIW+LG Sbjct: 768 KLTDFGFCATINEAQNKR---------TTMVGTPYWMAPE---VVTRKEYGRKVDIWSLG 815 Query: 1380 CLMYRICYLKSAFDGESKLQIL-----NGNYRIPELPKYCSSITSLIEEMLQSSPDAR 1538 + + + + ES L+ L NG +I + + L+ PD R Sbjct: 816 IMAIEMIEGEPPYLTESPLRALWLIATNGTPQIKDEGNMSPVFRDFLYFALKVDPDKR 873
>Q8IY84:NIM1_HUMAN Serine/threonine-protein kinase NIM1 - Homo sapiens (Human)| Length = 436 Score = 72.8 bits (177), Expect = 8e-12 Identities = 83/264 (31%), Positives = 114/264 (43%), Gaps = 8/264 (3%) Frame = +3 Query: 771 VREAIAEGGFSCVYLA-RDLTNPAKHYALKHVIVQDKESLDLVHKEITVMRALKGHPNVV 947 +R I G FS V L LT + D+++ L+ +EI+ M L HPN++ Sbjct: 76 IRGEIGSGNFSQVKLGIHSLTKEKVAIKILDKTKLDQKTQRLLSREISSMEKLH-HPNII 134 Query: 948 TL--VAHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFA 1121 L V T+ + L+ME+ T G + + LIF I +AV Sbjct: 135 RLYEVVETLSKLH------LVMEYAGGG--ELFGKISTEGKLSEPESKLIFSQIVSAVKH 186 Query: 1122 MHCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHTTP 1301 MH + HRDLKAENV ++ K+ DFG F ++G E + +P Sbjct: 187 MH--ENQIIHRDLKAENVFYTSNTCVKVGDFG--------FSTVSKKG--EMLNTFCGSP 234 Query: 1302 AYRAPEMWDLYRRE-VISEKVDIWALGCLMYRICYLKSAFDGES----KLQILNGNYRIP 1466 Y APE L+R E I VDIWALG L+Y + F E+ K IL G Y +P Sbjct: 235 PYAAPE---LFRDEHYIGIYVDIWALGVLLYFMVTGTMPFRAETVAKLKKSILEGTYSVP 291 Query: 1467 ELPKYCSSITSLIEEMLQSSPDAR 1538 P LI +LQ P R Sbjct: 292 --PHVSEPCHRLIRGVLQQIPTER 313
>Q9HC98:NEK6_HUMAN Serine/threonine-protein kinase Nek6 - Homo sapiens (Human)| Length = 313 Score = 72.8 bits (177), Expect = 8e-12 Identities = 79/277 (28%), Positives = 120/277 (43%), Gaps = 15/277 (5%) Frame = +3 Query: 771 VREAIAEGGFSCVYLARDLTNPAKHYALKHVIV---QDKESLDLVHKEITVMRALKGHPN 941 + + I G FS VY A L + K ALK V + D ++ KEI +++ L HPN Sbjct: 47 IEKKIGRGQFSEVYKATCLLD-RKTVALKKVQIFEMMDAKARQDCVKEIGLLKQLN-HPN 104 Query: 942 VVTLVAHTILDMGRGREALLLMEFCERSLVSALDA--RGTAGFYDDEQVALIFRDICNAV 1115 ++ + I D E +++E + +S + + + V F +C+AV Sbjct: 105 IIKYLDSFIED----NELNIVLELADAGDLSQMIKYFKKQKRLIPERTVWKYFVQLCSAV 160 Query: 1116 FAMHCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHT 1295 MH + V HRD+K NV + A G KL D G R + H+ Sbjct: 161 EHMHSRR--VMHRDIKPANVFITATGVVKLGDLGL------------GRFFSSETTAAHS 206 Query: 1296 ---TPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQILNGNYRI- 1463 TP Y +PE + K DIW+LGCL+Y + L+S F G+ K+ + + +I Sbjct: 207 LVGTPYYMSPER---IHENGYNFKSDIWSLGCLLYEMAALQSPFYGD-KMNLFSLCQKIE 262 Query: 1464 ----PELP--KYCSSITSLIEEMLQSSPDARPDITQV 1556 P LP Y + L+ + P RPDI V Sbjct: 263 QCDYPPLPGEHYSEKLRELVSMCICPDPHQRPDIGYV 299
>Q99JP0:M4K3_MOUSE Mitogen-activated protein kinase kinase kinase kinase 3 - Mus| musculus (Mouse) Length = 894 Score = 72.8 bits (177), Expect = 8e-12 Identities = 69/266 (25%), Positives = 121/266 (45%), Gaps = 10/266 (3%) Frame = +3 Query: 777 EAIAEGGFSCVYLARDLTNPAKHYALKHVIVQDKESLDLVHKEITVMRALKGHPNVVTLV 956 + I G + VY AR++ N + A+K + ++ E +V +EI +M+ K HPN+V Sbjct: 20 QRIGSGTYGDVYKARNV-NTGELAAIKVIKLEPGEDFAVVQQEIIMMKDCK-HPNIVAYF 77 Query: 957 AHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAMHCQT 1136 + R + + MEFC S D G + Q+A + R+ ++ +H + Sbjct: 78 GSYL----RRDKLWICMEFCGGG--SLQDIYHVTGPLSELQIAYVSRETLQGLYYLHSKG 131 Query: 1137 PPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHT---TPAY 1307 HRD+K N+LL +G KL DFG VS I I ++ + TP + Sbjct: 132 K--MHRDIKGANILLTDNGHVKLADFG-VSAQ-----------ITATIAKRKSFIGTPYW 177 Query: 1308 RAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQIL----NGNYRIPELP 1475 APE+ + R+ ++ D+WA+G + L+ ++ L N++ P+L Sbjct: 178 MAPEVAAVERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLK 237 Query: 1476 ---KYCSSITSLIEEMLQSSPDARPD 1544 K+ +S ++ L +P RP+ Sbjct: 238 DKLKWSNSFHHFVKMALTKNPKKRPN 263
>Q9HGY5:PHO85_CANAL Negative regulator of the PHO system - Candida albicans (Yeast)| Length = 326 Score = 72.4 bits (176), Expect = 1e-11 Identities = 66/236 (27%), Positives = 103/236 (43%), Gaps = 3/236 (1%) Frame = +3 Query: 777 EAIAEGGFSCVYLARDLTNPAKHYALKHVIVQDKESL-DLVHKEITVMRALKGHPNVVTL 953 E + EG ++ VY R+ A ALK + + +E +EI++M+ L H N+VTL Sbjct: 12 EKLGEGTYATVYKGRNRATGAL-VALKEISLDSEEGTPSTAIREISLMKELD-HENIVTL 69 Query: 954 --VAHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAMH 1127 V HT + L+ E+ ++ L ++ G D + V + + M Sbjct: 70 YDVIHT------ENKLTLVFEYMDKDLKKYMEVHGQQSALDLKVVKSFMFQLLKGI--MF 121 Query: 1128 CQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHTTPAY 1307 C V HRDLK +N+L+ G KL DFG + F P E + T Y Sbjct: 122 CHDNRVLHRDLKPQNLLINNKGELKLGDFGLA----RAFGIPFNTFSNEVV-----TLWY 172 Query: 1308 RAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQILNGNYRIPELP 1475 RAP++ L + +DIW+ GC+ +C K F G + L +R+ P Sbjct: 173 RAPDV--LLGSRAYTTSIDIWSAGCIFAEMCTGKPLFPGTANEDQLIKIFRLMGTP 226
>Q8BHI9:NIM1_MOUSE Serine/threonine-protein kinase NIM1 - Mus musculus (Mouse)| Length = 436 Score = 72.4 bits (176), Expect = 1e-11 Identities = 84/290 (28%), Positives = 124/290 (42%), Gaps = 7/290 (2%) Frame = +3 Query: 771 VREAIAEGGFSCVYLA-RDLTNPAKHYALKHVIVQDKESLDLVHKEITVMRALKGHPNVV 947 +R I G FS V L LT + D+++ L+ +EI+ M L HPN+V Sbjct: 76 IRGEIGSGNFSQVKLGIHSLTKEKVAIKILDKTKLDQKTQRLLSREISSMEKLH-HPNIV 134 Query: 948 TL--VAHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFA 1121 L V T+ + L+ME+ T G + + LIF I +AV Sbjct: 135 RLYEVVETLSKLH------LVMEYAGGG--ELFGKISTEGKLSEPESKLIFSQILSAVKH 186 Query: 1122 MHCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHTTP 1301 MH + HRDLKAENV + K+ DFG F ++G E + +P Sbjct: 187 MH--ENQIIHRDLKAENVFYTSRTCVKVGDFG--------FSTVSKKG--EMLNTFCGSP 234 Query: 1302 AYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGES----KLQILNGNYRIPE 1469 Y APE++ + + VDIWALG L+Y + F E+ K IL G Y IP+ Sbjct: 235 PYAAPELF--RDQHYVGVYVDIWALGVLLYFMVTGTMPFRAETVAKLKKSILEGTYTIPQ 292 Query: 1470 LPKYCSSITSLIEEMLQSSPDARPDITQVWFRVNELLPLELQKDLPDGSP 1619 LI +LQ +P R + +N ++ E + +P +P Sbjct: 293 --HVSEPCHRLIRGVLQPTPTER-------YGINYIMSNEWMRGVPYPTP 333
>Q8IVH8:M4K3_HUMAN Mitogen-activated protein kinase kinase kinase kinase 3 - Homo| sapiens (Human) Length = 894 Score = 72.4 bits (176), Expect = 1e-11 Identities = 69/265 (26%), Positives = 120/265 (45%), Gaps = 10/265 (3%) Frame = +3 Query: 777 EAIAEGGFSCVYLARDLTNPAKHYALKHVIVQDKESLDLVHKEITVMRALKGHPNVVTLV 956 + I G + VY AR++ N + A+K + ++ E +V +EI +M+ K HPN+V Sbjct: 20 QRIGSGTYGDVYKARNV-NTGELAAIKVIKLEPGEDFAVVQQEIIMMKDCK-HPNIVAYF 77 Query: 957 AHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAMHCQT 1136 + R + + MEFC S D G + Q+A + R+ ++ +H + Sbjct: 78 GSYL----RRDKLWICMEFCGGG--SLQDIYHVTGPLSELQIAYVSRETLQGLYYLHSKG 131 Query: 1137 PPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHT---TPAY 1307 HRD+K N+LL +G KL DFG VS I I ++ + TP + Sbjct: 132 K--MHRDIKGANILLTDNGHVKLADFG-VSAQ-----------ITATIAKRKSFIGTPYW 177 Query: 1308 RAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQIL----NGNYRIPELP 1475 APE+ + R+ ++ D+WA+G + L+ ++ L N++ P+L Sbjct: 178 MAPEVAAVERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLK 237 Query: 1476 ---KYCSSITSLIEEMLQSSPDARP 1541 K+ +S ++ L +P RP Sbjct: 238 DKMKWSNSFHHFVKMALTKNPKKRP 262
>Q2TBL8:CDK10_BOVIN Cell division protein kinase 10 - Bos taurus (Bovine)| Length = 361 Score = 72.4 bits (176), Expect = 1e-11 Identities = 66/221 (29%), Positives = 109/221 (49%), Gaps = 3/221 (1%) Frame = +3 Query: 783 IAEGGFSCVYLARDLTNPAKHYALKHVIV-QDKESLDLVH-KEITVMRALKGHPNVVTLV 956 I EG + VY ARD T+ + ALK V + ++K+ + + +EIT++ L+ HPN+V L Sbjct: 43 IGEGTYGIVYRARD-THTDEIVALKKVRMDKEKDGVPISSLREITLLLRLR-HPNIVELK 100 Query: 957 AHTILDMGRGREAL-LLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAMHCQ 1133 + G E++ L+M +CE+ L S L+ T + + QV I + + +H Sbjct: 101 EVVV---GNHLESIFLVMGYCEQDLASLLENMPTP--FSEAQVKCIVLQVLRGLQYLHRN 155 Query: 1134 TPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHTTPAYRA 1313 + HRDLK N+L+ G K DFG + + P + + K T YRA Sbjct: 156 F--IIHRDLKVSNLLMTDKGCVKTADFGLA----RAYGIP-----VKPMTPKVVTLWYRA 204 Query: 1314 PEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKL 1436 PE+ L + +D+WA+GC++ + K G S++ Sbjct: 205 PEL--LLGTTTQTTSIDMWAVGCILAELLAHKPLLPGTSEI 243
>P25390:SSK22_YEAST Serine/threonine-protein kinase SSK22 - Saccharomyces cerevisiae| (Baker's yeast) Length = 1331 Score = 72.0 bits (175), Expect = 1e-11 Identities = 79/277 (28%), Positives = 127/277 (45%), Gaps = 22/277 (7%) Frame = +3 Query: 774 REAIAEGGFSCVYLARDLTNPAKHYALKHVIVQD----KESLDLVHKEITVMRALKGHPN 941 R I G F VY A +L N + A+K + + D K+ L+ +E+TV+ L HPN Sbjct: 1037 RSFIGGGTFGQVYSAINLEN-GEILAVKEIKIHDTTTMKKIFPLIKEEMTVLEMLN-HPN 1094 Query: 942 VVTLVAHTILDMGRGREALLLMEFCER-SLVSALDARGTAGFYDDEQVALIFR-DICNAV 1115 +V +++ R + + ME+CE SL S LD G +DE V ++ ++ + Sbjct: 1095 IVQYYG---VEVHRDK-VNIFMEYCEGGSLASLLDH----GRIEDEMVTQVYTFELLEGL 1146 Query: 1116 FAMHCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKP------EERGIEED 1277 +H V HRD+K EN+LL +G K DFG+ T + ++ G+E Sbjct: 1147 AYLH--QSGVVHRDIKPENILLDFNGIIKYVDFGTARTVVGSRTRTVRNAAVQDFGVETK 1204 Query: 1278 IIRKHT-TPAYRAPEMWDLYRREVISEKV---DIWALGCLMYRICYLK---SAFDGESKL 1436 + + TP Y APE + K+ D+WALGC++ + + S D E + Sbjct: 1205 SLNEMMGTPMYMAPE---TISGSAVKGKLGADDVWALGCVVLEMATGRRPWSNLDNEWAI 1261 Query: 1437 QILNGNYRIPELP---KYCSSITSLIEEMLQSSPDAR 1538 RIP+LP + ++ + +E L P R Sbjct: 1262 MYHVAAGRIPQLPNRDEMTAAGRAFLERCLVQDPTMR 1298
>P48479:NIM1_NEUCR G2-specific protein kinase nim-1 - Neurospora crassa| Length = 779 Score = 72.0 bits (175), Expect = 1e-11 Identities = 74/297 (24%), Positives = 123/297 (41%), Gaps = 36/297 (12%) Frame = +3 Query: 762 KVHVREAIAEGGFSCVYLARDLTNPA----KHYALKHVIVQDKESLDLVHKEITVMRALK 929 K + E I G F + R + K + + +++E L H E +++ L+ Sbjct: 6 KYELLEKIGHGSFGIIRKVRRKADGMILCRKEISYLKMSQKEREQL---HAEFSILSTLR 62 Query: 930 GHPNVVTLVAHTILDMGRGREALLLMEFCERSLVSAL--DARGTAGFYDDEQVALIFRDI 1103 HPN+V L + + L ME+C + + + + ++ V IF + Sbjct: 63 -HPNIVGYYHREHLKATQ--DLHLYMEYCGNGDLGRVIRNLIKNNQYAEESFVWSIFSQL 119 Query: 1104 CNAVFAMHCQTPP------------------------VAHRDLKAENVLLGADGAWKLCD 1211 A++ H P + HRDLK ENV LG D + KL D Sbjct: 120 VTALYRCHYGVDPPEVGKTVLGLGSTARPKPPSGGMTILHRDLKPENVFLGEDNSVKLGD 179 Query: 1212 FG--SVSTNHKCFDKPEERGIEEDIIRKHT-TPAYRAPEMWDLYRREVISEKVDIWALGC 1382 FG V +H D + TP Y +PE + E + K DIW+LGC Sbjct: 180 FGLSKVMQSH-------------DFASTYVGTPFYMSPE---ICAAEKYTLKSDIWSLGC 223 Query: 1383 LMYRICYLKSAFDGESKLQILN--GNYRIPELPK-YCSSITSLIEEMLQSSPDARPD 1544 ++Y +C + F+ ++ Q++ +I LP Y + + I++ L+ +PD RPD Sbjct: 224 IIYELCAREPPFNAKTHYQLVQKIKEGKIAPLPSVYSGELFATIKDCLRVNPDRRPD 280
>Q9Z2A6:MK15_RAT Mitogen-activated protein kinase 15 - Rattus norvegicus (Rat)| Length = 547 Score = 72.0 bits (175), Expect = 1e-11 Identities = 70/261 (26%), Positives = 120/261 (45%), Gaps = 8/261 (3%) Frame = +3 Query: 771 VREAIAEGGFSCVYLARDLTNPAKHYALKHVI--VQDKESLDLVHKEITVMRALKGHPNV 944 ++ + +G + V+ A D + A+K + +D+ +EI ++R GHPN+ Sbjct: 16 IKRRLGKGAYGIVWKAMD-RRTGEVVAIKKIFDAFRDQTDAQRTFREIMLLREFGGHPNI 74 Query: 945 VTLVAHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAM 1124 + L+ ++ R+ L+ E + L +A+ +G +D IF + A + Sbjct: 75 IRLL--DVIPAKNDRDIYLVFESMDTDL-NAVIQKGR--LLEDIHKRCIFYQLLRATKFI 129 Query: 1125 HCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHTTPA 1304 H + V HRD K NVLL A KLCDFG + + P + + E + T Sbjct: 130 H--SGRVIHRDQKPANVLLDAACRVKLCDFGLARSLSDFPEGPGGQALTEYV----ATRW 183 Query: 1305 YRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGES---KLQILNGNYRIP--- 1466 YRAPE+ L + VD+W+LGC++ + + F G S +L+++ +P Sbjct: 184 YRAPEV--LLSSRWYTPGVDMWSLGCILGEMLRGQPLFPGTSTFHQLELILETIPLPSME 241 Query: 1467 ELPKYCSSITSLIEEMLQSSP 1529 EL S ++LI + L S P Sbjct: 242 ELQGLGSDYSALILQNLGSRP 262
>O94737:MAPK1_PNECA Mitogen-activated protein kinase 1 - Pneumocystis carinii| Length = 370 Score = 72.0 bits (175), Expect = 1e-11 Identities = 61/232 (26%), Positives = 107/232 (46%), Gaps = 6/232 (2%) Frame = +3 Query: 771 VREAIAEGGFSCVYLARDL-TNPAKHYALKHV--IVQDKESLDLVHKEITVMRALKGHPN 941 V + + +G + V A+++ A+K + I K +EI +++ + H N Sbjct: 23 VIKGLGKGSYGVVCSAKNIEVEDNNKVAIKKITNIFSKKMLAKRALREIMLLQHFRNHKN 82 Query: 942 VVTLVAHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFA 1121 + TL I+D + E L E + +L S + R D + I++ +C + Sbjct: 83 ITTLYDMDIVDPSKFNELYLYEELMQANLNSII--RSDQPLTDAHFQSFIYQILCGLKYI 140 Query: 1122 MHCQTPPVAHRDLKAENVLLGADGAWKLCDFG---SVSTNHKCFDKPEERGIEEDIIRKH 1292 + V HRDLK N+L+ AD K+CDFG +S N + +G E + Sbjct: 141 ---HSANVLHRDLKPSNLLINADCKLKICDFGLSRGISVN-------QGQGTEY-MTEYV 189 Query: 1293 TTPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQILN 1448 TT YRAPE+ + + S+ +D+W++GC++ + K F G + + LN Sbjct: 190 TTRWYRAPEV--MLSFQSYSKAIDLWSVGCILAELLGRKPFFKGSNYVDQLN 239
>Q00526:CDK3_HUMAN Cell division protein kinase 3 - Homo sapiens (Human)| Length = 305 Score = 72.0 bits (175), Expect = 1e-11 Identities = 81/306 (26%), Positives = 136/306 (44%), Gaps = 12/306 (3%) Frame = +3 Query: 777 EAIAEGGFSCVYLARDLTNPAKHYALKHVIVQ-DKESL-DLVHKEITVMRALKGHPNVVT 950 E I EG + VY A++ + ALK + + + E + +EI++++ LK HPN+V Sbjct: 8 EKIGEGTYGVVYKAKN-RETGQLVALKKIRLDLEMEGVPSTAIREISLLKELK-HPNIVR 65 Query: 951 LVAHTILDMGRG-REALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAMH 1127 L LD+ R+ L+ EF + L +D+ + + +F+ + F Sbjct: 66 L-----LDVVHNERKLYLVFEFLSQDLKKYMDSTPGSELPLHLIKSYLFQLLQGVSF--- 117 Query: 1128 CQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHTTPAY 1307 C + V HRDLK +N+L+ GA KL DFG + F P E + T Y Sbjct: 118 CHSHRVIHRDLKPQNLLINELGAIKLADFGLA----RAFGVPLRTYTHEVV-----TLWY 168 Query: 1308 RAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQILNGNYRIPELPKYCS 1487 RAPE+ L + + VDIW++GC+ + K+ F G+S++ L +R+ P Sbjct: 169 RAPEI--LLGSKFYTTAVDIWSIGCIFAEMVTRKALFPGDSEIDQLFRIFRMLGTP---- 222 Query: 1488 SITSLIEEMLQSSPDARPDITQV---------WFRVNELLPLELQKDLPDGSPSGSAFEL 1640 S D P +TQ+ W R L++ +P+ P G + Sbjct: 223 ------------SEDTWPGVTQLPDYKGSFPKWTRKG------LEEIVPNLEPEGRDLLM 264 Query: 1641 QITEHE 1658 Q+ +++ Sbjct: 265 QLLQYD 270
>Q9XZD6:CDC2H_PLAVI Cell division control protein 2 homolog - Plasmodium vivax| Length = 288 Score = 72.0 bits (175), Expect = 1e-11 Identities = 70/256 (27%), Positives = 115/256 (44%), Gaps = 16/256 (6%) Frame = +3 Query: 762 KVHVREAIAEGGFSCVYLARDLTNPAKHYALKHVIVQ--DKESLDLVHKEITVMRALKGH 935 K H E I EG + VY A++ N + +ALK + ++ D+ +EI++++ LK H Sbjct: 3 KYHGLEKIGEGTYGVVYKAQN--NYGETFALKKIRLEKEDEGIPSTAIREISILKELK-H 59 Query: 936 PNVVTL--VAHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICN 1109 N+V L V HT + +L+ E ++ L LD G + + + Sbjct: 60 SNIVKLYDVIHT------KKRLILVFEHLDQDLKKLLDV--CDGGLESVTAKSFLLQLLS 111 Query: 1110 AVFAMHCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRK 1289 + +C V HRDLK +N+L+ +G K+ DFG + F P + E + Sbjct: 112 GI--AYCHEHRVLHRDLKPQNLLINREGELKIADFGLA----RAFGIPVRKYTHEVV--- 162 Query: 1290 HTTPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQILNGNYRI-- 1463 T YRAP++ L + S +D+W++GC+ + + F G S+ L +RI Sbjct: 163 --TLWYRAPDI--LMGSKKYSTPIDMWSVGCIFAEMVNGRPLFPGVSETDQLMRIFRILG 218 Query: 1464 ----------PELPKY 1481 ELPKY Sbjct: 219 TPNSENWPNVTELPKY 234
>O14965:STK6_HUMAN Serine/threonine-protein kinase 6 - Homo sapiens (Human)| Length = 403 Score = 71.6 bits (174), Expect = 2e-11 Identities = 73/285 (25%), Positives = 118/285 (41%), Gaps = 14/285 (4%) Frame = +3 Query: 783 IAEGGFSCVYLARDLTNPAKHYALKHVIVQDKESLDLVH---KEITVMRALKGHPNVVTL 953 + +G F VYLAR+ + ALK + E + H +E+ + L+ HPN++ L Sbjct: 139 LGKGKFGNVYLAREKQSKFI-LALKVLFKAQLEKAGVEHQLRREVEIQSHLR-HPNILRL 196 Query: 954 VAHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAMHCQ 1133 + L++E+ L + +D+++ A ++ NA+ +C Sbjct: 197 YGY----FHDATRVYLILEYAP--LGTVYRELQKLSKFDEQRTATYITELANAL--SYCH 248 Query: 1134 TPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHT---TPA 1304 + V HRD+K EN+LLG+ G K+ DFG + R+ T T Sbjct: 249 SKRVIHRDIKPENLLLGSAGELKIADFG--------------WSVHAPSSRRTTLCGTLD 294 Query: 1305 YRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDG----ESKLQILNGNYRIPEL 1472 Y PEM + EKVD+W+LG L Y K F+ E+ +I + P+ Sbjct: 295 YLPPEM---IEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDF 351 Query: 1473 PKYCSSITSLIEEMLQSSPDARPDITQV----WFRVNELLPLELQ 1595 LI +L+ +P RP + +V W N P Q Sbjct: 352 --VTEGARDLISRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQ 394
>Q00372:SNF1_CANGA Carbon catabolite derepressing protein kinase - Candida glabrata| (Yeast) (Torulopsis glabrata) Length = 612 Score = 71.6 bits (174), Expect = 2e-11 Identities = 83/321 (25%), Positives = 149/321 (46%), Gaps = 18/321 (5%) Frame = +3 Query: 750 VGNVKVHVREAIAEGGFSCVYLARDLTNPAKHYALKHV---IVQDKESLDLVHKEITVMR 920 VGN ++ + + EG F V LA +T K ALK + ++ + + +EI+ +R Sbjct: 36 VGNYQIV--KTLGEGSFGKVKLAYHVTTGQK-VALKIINKKVLAKSDMQGRIEREISYLR 92 Query: 921 ALKGHPNVVTLVAHTILDMGRGR-EALLLMEFCERSLVSALDARGTAGFYDDEQVALIFR 1097 L+ HP+++ L D+ + + E ++++E+ L + R +++ F+ Sbjct: 93 LLR-HPHIIKLY-----DVIKSKDEIIMVIEYAGNELFDYIVQRNKMS---EQEARRFFQ 143 Query: 1098 DICNAVFAMHCQTPPVAHRDLKAENVLLGADGAWKLCDFG--SVSTNHKCFDKPEERGIE 1271 I +AV +C + HRDLK EN+LL K+ DFG ++ T+ Sbjct: 144 QIISAV--EYCHRHKIVHRDLKPENLLLDEHLNVKIADFGLSNIMTDGNF---------- 191 Query: 1272 EDIIRKHTTPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGES----KLQ 1439 + +P Y APE+ + + +VD+W+ G ++Y + + FD ES Sbjct: 192 --LKTSCGSPNYAAPEV--ISGKLYAGPEVDVWSCGVILYVMLCRRLPFDDESIPVLFKN 247 Query: 1440 ILNGNYRIPELPKYCS-SITSLIEEMLQSSPDARPDITQV----WFRVN---ELLPLELQ 1595 I NG Y LPK+ S + LI+ ML +P R I ++ WF+V+ L+P +L+ Sbjct: 248 ISNGVY---TLPKFLSPGASDLIKRMLIVNPLNRISIHEIMQDEWFKVDLAEYLVPQDLK 304 Query: 1596 KDLPDGSPSGSAFELQITEHE 1658 + SG+ ++ + E Sbjct: 305 QQEQFNKKSGNEENVEEIDDE 325
>Q75V63:SAPK3_ORYSA Serine/threonine-protein kinase SAPK3 - Oryza sativa (Rice)| Length = 334 Score = 71.6 bits (174), Expect = 2e-11 Identities = 76/294 (25%), Positives = 123/294 (41%), Gaps = 22/294 (7%) Frame = +3 Query: 783 IAEGGFSCVYLARDLTNPAKHYALKHVIVQDKESLDLVHKEITVMRALKGHPNVVTLV-- 956 + G F L RD +K I + K+ + V +EI R+L+ HPN++ Sbjct: 11 LGAGNFGVARLVRD--KRSKELVAVKYIERGKKIDENVQREIINHRSLR-HPNIIRFKEV 67 Query: 957 ----AHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAM 1124 H + M L + C TAG + +++ F+ + + V Sbjct: 68 CLTPTHLAIVMEYAAGGELFEQIC------------TAGRFSEDEARYFFQQLISGV--S 113 Query: 1125 HCQTPPVAHRDLKAENVLLGADGA----WKLCDFGSVSTNHKCFDKPEERGIEEDIIRKH 1292 +C + + HRDLK EN LL DG+ K+CDFG S + KP+ Sbjct: 114 YCHSLEICHRDLKLENTLL--DGSPTPRVKICDFG-YSKSALLHSKPKS---------TV 161 Query: 1293 TTPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDG--------ESKLQILN 1448 TPAY APE+ L R+E + D+W+ G +Y + F+ ++ +IL Sbjct: 162 GTPAYIAPEV--LSRKEYDGKVADVWSCGVTLYVMLVGSYPFEDPGDPRNFRKTISRILG 219 Query: 1449 GNYRIPELPKYCSSITSLIEEMLQSSPDARPDITQV----WFRVNELLPLELQK 1598 Y IP+ + S L+ ++ + P R I ++ WF N LP E+ + Sbjct: 220 VQYSIPDYVRVSSDCRRLLSQIFVADPSKRITIPEIKKHTWFLKN--LPKEISE 271
>Q75LR7:SAPK1_ORYSJ Serine/threonine-protein kinase SAPK1 - Oryza sativa subsp. japonica| (Rice) Length = 342 Score = 71.6 bits (174), Expect = 2e-11 Identities = 74/293 (25%), Positives = 125/293 (42%), Gaps = 16/293 (5%) Frame = +3 Query: 762 KVHVREAIAEGGFSCVYLARDLTNPAKHYALKHVIVQDKESLDLVHKEITVMRALKGHPN 941 + V I G F L RD+ H I + + + V +EI R+LK HPN Sbjct: 3 RYEVMRDIGSGNFGVAKLVRDVAT--NHLFAVKFIERGLKIDEHVQREIMNHRSLK-HPN 59 Query: 942 VVTLVAHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFA 1121 ++ + ++ME+ + AG + +++ F+ + + V Sbjct: 60 IIRFKEVVLTPT----HLAIVMEYAAGG--ELFERICNAGRFSEDEARFFFQQLISGV-- 111 Query: 1122 MHCQTPPVAHRDLKAENVLLGADGA----WKLCDFGSVSTNHKCFDKPEERGIEEDIIRK 1289 +C + V HRDLK EN LL DG+ K+CDFG S + +P+ Sbjct: 112 SYCHSMQVCHRDLKLENTLL--DGSVTPRLKICDFG-YSKSSVLHSQPKS---------T 159 Query: 1290 HTTPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDG--------ESKLQIL 1445 TPAY APE+ L R+E + D+W+ G +Y + F+ ++ +IL Sbjct: 160 VGTPAYIAPEV--LSRKEYDGKVADVWSCGVTLYVMLVGAYPFEDPDDPRNFRKTITRIL 217 Query: 1446 NGNYRIPELPKYCSSITSLIEEMLQSSPDARPDITQV----WFRVNELLPLEL 1592 + Y IP+ + + L+ + +P+ R I ++ WF N LP+E+ Sbjct: 218 SVQYSIPDYVRVSADCRHLLSRIFVGNPEQRITIPEIKNHPWFLKN--LPIEM 268
>Q8BTW9:PAK4_MOUSE Serine/threonine-protein kinase PAK 4 - Mus musculus (Mouse)| Length = 593 Score = 71.6 bits (174), Expect = 2e-11 Identities = 70/257 (27%), Positives = 120/257 (46%), Gaps = 5/257 (1%) Frame = +3 Query: 783 IAEGGFSCVYLARDLTNPAKHYALKHVIVQDKESLDLVHKEITVMRALKGHPNVVTLVAH 962 I EG V +A + + K A+K + ++ ++ +L+ E+ +MR + H NVV + Sbjct: 329 IGEGSTGIVCIAT-VRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYR-HENVVEMYNS 386 Query: 963 TILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAMHCQTPP 1142 ++ G E ++MEF E AL T ++EQ+A + + A+ +H Q Sbjct: 387 YLV----GDELWVVMEFLEGG---ALTDIVTHTRMNEEQIAAVCLAVLQALAVLHAQG-- 437 Query: 1143 VAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHTTPAYRAPEM 1322 V HRD+K++++LL DG KL DFG + K + P + + TP + APE Sbjct: 438 VIHRDIKSDSILLTHDGRVKLSDFGFCAQVSK--EVPRRKSLV-------GTPYWMAPE- 487 Query: 1323 WDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQIL-----NGNYRIPELPKYCS 1487 L R +VDIW+LG ++ + + + E L+ + N R+ L K Sbjct: 488 --LISRLPYGPEVDIWSLGVMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKASP 545 Query: 1488 SITSLIEEMLQSSPDAR 1538 S+ ++ +L P R Sbjct: 546 SLKGFLDRLLVRDPAQR 562
>O96013:PAK4_HUMAN Serine/threonine-protein kinase PAK 4 - Homo sapiens (Human)| Length = 591 Score = 71.6 bits (174), Expect = 2e-11 Identities = 70/257 (27%), Positives = 120/257 (46%), Gaps = 5/257 (1%) Frame = +3 Query: 783 IAEGGFSCVYLARDLTNPAKHYALKHVIVQDKESLDLVHKEITVMRALKGHPNVVTLVAH 962 I EG V +A + + K A+K + ++ ++ +L+ E+ +MR + H NVV + Sbjct: 327 IGEGSTGIVCIAT-VRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQ-HENVVEMYNS 384 Query: 963 TILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAMHCQTPP 1142 ++ G E ++MEF E AL T ++EQ+A + + A+ +H Q Sbjct: 385 YLV----GDELWVVMEFLEGG---ALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQG-- 435 Query: 1143 VAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHTTPAYRAPEM 1322 V HRD+K++++LL DG KL DFG + K + P + + TP + APE Sbjct: 436 VIHRDIKSDSILLTHDGRVKLSDFGFCAQVSK--EVPRRKSLV-------GTPYWMAPE- 485 Query: 1323 WDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQIL-----NGNYRIPELPKYCS 1487 L R +VDIW+LG ++ + + + E L+ + N R+ L K Sbjct: 486 --LISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSP 543 Query: 1488 SITSLIEEMLQSSPDAR 1538 S+ ++ +L P R Sbjct: 544 SLKGFLDRLLVRDPAQR 560
>P38990:PAK1_YEAST Serine/threonine-protein kinase PAK1 - Saccharomyces cerevisiae| (Baker's yeast) Length = 1142 Score = 71.6 bits (174), Expect = 2e-11 Identities = 68/243 (27%), Positives = 114/243 (46%), Gaps = 28/243 (11%) Frame = +3 Query: 888 DLVHKEITVMRALKGHPNVVTLVAHTILDMGRGREALLLMEFCERSLVS-------ALDA 1046 D + +EI +M+ H +VV L+ +LD + R+ L++E+C R V DA Sbjct: 187 DKIKREIAIMKKCH-HKHVVQLIE--VLDDLKSRKIYLVLEYCSRGEVKWCPPDCMESDA 243 Query: 1047 RGTAGFYDDEQVALIFRDICNAVFAMHCQTPPVAHRDLKAENVLLGADGAWKLCDFG-SV 1223 +G + ++ I R + + +H Q + HRD+K N+L+ DG K+ DFG S+ Sbjct: 244 KGPS-LLSFQETREILRGVVLGLEYLHYQG--IIHRDIKPANLLISGDGTVKISDFGVSL 300 Query: 1224 STNHKCFDKPEERGIEEDIIRKHTTPAYRAPEMW--------------DLYRREVISEKV 1361 + + E E ++ + TPA+ APEM +L+R IS + Sbjct: 301 AASSTNSSDSSESLDELELAKTVGTPAFFAPEMCLGEDAFTRYNLTKENLFRGSCISFMI 360 Query: 1362 DIWALGCLMYRICYLKSAF--DGESKL--QILNGNYRIPELPKYCSSITSLI--EEMLQS 1523 DIWA+G +Y + + F D E KL +I+N + P + S+ S + EE + Sbjct: 361 DIWAVGVTLYCLLFGMLPFFSDFELKLFEKIVNDPLKFPTFKEIQSNKVSKVSCEEEYEM 420 Query: 1524 SPD 1532 + D Sbjct: 421 AKD 423
>Q61846:MELK_MOUSE Maternal embryonic leucine zipper kinase - Mus musculus (Mouse)| Length = 643 Score = 71.6 bits (174), Expect = 2e-11 Identities = 81/291 (27%), Positives = 141/291 (48%), Gaps = 14/291 (4%) Frame = +3 Query: 777 EAIAEGGFSCVYLARDLTNPAKHYALKHVIVQDKESL--DL--VHKEITVMRALKGHPNV 944 E I GGF+ V LA + + A+K + DK +L DL V EI +++L+ H ++ Sbjct: 15 ETIGTGGFAKVKLACHVLT-GEMVAIK---IMDKNALGSDLPRVKTEIDALKSLR-HQHI 69 Query: 945 VTLVAHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAM 1124 L + +L+ + +++E+C D + +E+ ++FR I +AV + Sbjct: 70 CQL--YHVLETKN--KIFMVLEYCPGG--ELFDYIISQDRLSEEETRVVFRQILSAVAYV 123 Query: 1125 HCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHT-TP 1301 H Q AHRDLK EN+L + KL DFG + KP +G ++ ++ + Sbjct: 124 HSQG--YAHRDLKPENLLFDENHKLKLIDFGLCA-------KP--KGNKDYHLQTCCGSL 172 Query: 1302 AYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKL----QILNGNYRIPE 1469 AY APE+ + + + + D+W++G L+Y + FD ++ + +I+ G Y E Sbjct: 173 AYAAPEL--IQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKY---E 227 Query: 1470 LPKYCS-SITSLIEEMLQSSPDARPDITQV----WFRVNELLPLELQKDLP 1607 +PK+ S S L+++MLQ P R + + W + P+E Q P Sbjct: 228 VPKWLSPSSILLLQQMLQVDPKKRISMRNLLNHPWVMQDYSCPVEWQSKTP 278
>Q15131:CDK10_HUMAN Cell division protein kinase 10 - Homo sapiens (Human)| Length = 360 Score = 71.6 bits (174), Expect = 2e-11 Identities = 65/221 (29%), Positives = 108/221 (48%), Gaps = 3/221 (1%) Frame = +3 Query: 783 IAEGGFSCVYLARDLTNPAKHYALKHVIV-QDKESLDLVH-KEITVMRALKGHPNVVTLV 956 I EG + VY ARD T + ALK V + ++K+ + + +EIT++ L+ HPN+V L Sbjct: 45 IGEGTYGIVYRARD-TQTDEIVALKKVRMDKEKDGIPISSLREITLLLRLR-HPNIVELK 102 Query: 957 AHTILDMGRGREAL-LLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAMHCQ 1133 + G E++ L+M +CE+ L S L+ T + + QV I + + +H Sbjct: 103 EVVV---GNHLESIFLVMGYCEQDLASLLENMPTP--FSEAQVKCIVLQVLRGLQYLHRN 157 Query: 1134 TPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHTTPAYRA 1313 + HRDLK N+L+ G K DFG + + P + + K T YRA Sbjct: 158 F--IIHRDLKVSNLLMTDKGCVKTADFGLA----RAYGVP-----VKPMTPKVVTLWYRA 206 Query: 1314 PEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKL 1436 PE+ L + +D+WA+GC++ + + G S++ Sbjct: 207 PEL--LLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEI 245
>P43063:CDC28_CANAL Cell division control protein 28 - Candida albicans (Yeast)| Length = 317 Score = 71.6 bits (174), Expect = 2e-11 Identities = 61/236 (25%), Positives = 106/236 (44%), Gaps = 2/236 (0%) Frame = +3 Query: 774 REAIAEGGFSCVYLARDLTNPAKHYALKHVIVQDKES--LDLVHKEITVMRALKGHPNVV 947 +E + EG + VY A D + + ALK + ++ ++ +EI++++ +K N+V Sbjct: 10 QEKVGEGTYGVVYKALDTKHNNRVVALKKIRLESEDEGVPSTAIREISLLKEMKDD-NIV 68 Query: 948 TLVAHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAMH 1127 L D + L+ EF + L +++ + + + H Sbjct: 69 RLYDIIHSD---SHKLYLVFEFLDLDLKKYMESIPQGVGLGANMIKRFMNQLIRGI--KH 123 Query: 1128 CQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHTTPAY 1307 C + V HRDLK +N+L+ +G KL DFG + F P E + T Y Sbjct: 124 CHSHRVLHRDLKPQNLLIDKEGNLKLADFGLA----RAFGVPLRAYTHEVV-----TLWY 174 Query: 1308 RAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQILNGNYRIPELP 1475 RAPE+ L + S VD+W++GC+ +C K F G+S++ + +RI P Sbjct: 175 RAPEI--LLGGKQYSTGVDMWSVGCIFAEMCNRKPLFPGDSEIDEIFRIFRILGTP 228
>Q8CFH6:SN1L2_MOUSE Serine/threonine-protein kinase SNF1-like kinase 2 - Mus musculus| (Mouse) Length = 931 Score = 71.2 bits (173), Expect = 2e-11 Identities = 84/320 (26%), Positives = 140/320 (43%), Gaps = 17/320 (5%) Frame = +3 Query: 738 RTIDVGNVKV---HVREAIAEGGFSCVYLARDLTNPAKHYALKHVIVQDKESLDLV---- 896 R + G V+V + + +G F+ V L R T + A+K + DK LD V Sbjct: 8 RHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRTTKTE-VAIKII---DKSQLDAVNLEK 63 Query: 897 -HKEITVMRALKGHPNVVTLVAHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDD 1073 ++E+ +M+ L HP+++ L M L+ E+ + + D G ++ Sbjct: 64 IYREVQIMKMLD-HPHIIKLYQV----METKSMLYLVTEYAKNGEI--FDYLANHGRLNE 116 Query: 1074 EQVALIFRDICNAVFAMHCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKP 1253 + F I +AV +C V HRDLKAEN+LL + K+ DFG F Sbjct: 117 SEARRKFWQILSAVD--YCHGRKVVHRDLKAENLLLDNNMNIKIADFG--------FGNF 166 Query: 1254 EERGIEEDIIRKHTTPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGES- 1430 + G E + +P Y APE+++ + E ++DIW++G ++Y + FDG + Sbjct: 167 FKTG--ELLATWCGSPPYAAPEVFEGQQYE--GPQLDIWSMGVVLYVLVCGALPFDGPTL 222 Query: 1431 ---KLQILNGNYRIPELPKYCSSITSLIEEMLQSSPDARPDITQVWFRVNELLPLELQKD 1601 + ++L G +RIP LI ML P R I Q+ L+ + +Q+ Sbjct: 223 PILRQRVLEGRFRIPYF--MSEDCEHLIRRMLVLDPSKRLSIAQIKEHKWMLIEVPVQRP 280 Query: 1602 L-----PDGSPSGSAFELQI 1646 + + PS F Q+ Sbjct: 281 ILYPQEQENEPSIGEFNEQV 300
>Q9LDI3:CPK24_ARATH CBL-interacting serine/threonine-protein kinase 24 - Arabidopsis| thaliana (Mouse-ear cress) Length = 446 Score = 71.2 bits (173), Expect = 2e-11 Identities = 79/281 (28%), Positives = 127/281 (45%), Gaps = 11/281 (3%) Frame = +3 Query: 762 KVHVREAIAEGGFSCVYLARDLT---NPAKHYALKHVIVQDKESLDLVHKEITVMRALKG 932 K V I EG F+ V AR+ N A K I++++ +D + +EI++M+ ++ Sbjct: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNR-MVDQIKREISIMKIVR- 67 Query: 933 HPNVVTLVAHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNA 1112 HPN+V L + + +++EF D G ++ + F+ + +A Sbjct: 68 HPNIVRLYEV----LASPSKIYIVLEFVTGG--ELFDRIVHKGRLEESESRKYFQQLVDA 121 Query: 1113 VFAMHCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKH 1292 V HC V HRDLK EN+LL +G K+ DFG + P+E G+E ++R Sbjct: 122 V--AHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLSAL-------PQE-GVE--LLRTT 169 Query: 1293 T-TPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQILNGNYRIPE 1469 TP Y APE+ L + DIW+ G +++ I F E+ L L E Sbjct: 170 CGTPNYVAPEV--LSGQGYDGSAADIWSCGVILFVILAGYLPF-SETDLPGLYRKINAAE 226 Query: 1470 L---PKYCSSITSLIEEMLQSSPDARPDITQV----WFRVN 1571 P + + + LI +L +P R I + WFR+N Sbjct: 227 FSCPPWFSAEVKFLIHRILDPNPKTRIQIQGIKKDPWFRLN 267
>P28582:CDPK_DAUCA Calcium-dependent protein kinase - Daucus carota (Carrot)| Length = 532 Score = 71.2 bits (173), Expect = 2e-11 Identities = 81/310 (26%), Positives = 129/310 (41%), Gaps = 19/310 (6%) Frame = +3 Query: 693 LMPKE-HSGPSGGLEGRTIDVGNVKVHVREAIAEGGFSCVYLARDLTNPAKHYALKHVIV 869 L P++ H S + G+ + K + + + G F CVY + + + YA K ++ Sbjct: 56 LKPRQVHRPESNTILGKPFEDIRGKYTLGKELGRGQFGCVYQCTE-NSSGQLYACKSILK 114 Query: 870 Q---DKESLDLVHKEITVMRALKGHPNVVTLVAHTILDMGRGREAL-LLMEFCERSLVSA 1037 + K + + +EI +++ L G PN+V + R+++ L+ME C Sbjct: 115 RKLVSKNDKEDIKREIQILQHLSGQPNIVEFKG-----VFEDRQSVHLVMELCAGG--EL 167 Query: 1038 LDARGTAGFYDDEQVALIFRDICNAVFAMHCQTPPVAHRDLKAENVLLGA---DGAWKLC 1208 D G Y + A I R I N V H V HRDLK EN LL + D K Sbjct: 168 FDRIIAQGHYSERAAATICRQIVNVVHVCHFMG--VMHRDLKPENFLLSSKDKDAMLKAT 225 Query: 1209 DFG-SVSTNHKCFDKPEERGIEEDIIRKHTTPAYRAPEMWDLYRREVISEKVDIWALGCL 1385 DFG SV EE + +I+ + Y APE+ R +++DIW+ G + Sbjct: 226 DFGLSVFI--------EEGKVYRNIV---GSAYYVAPEV----LRRSYGKEIDIWSAGVI 270 Query: 1386 MYRICYLKSAFDGESKLQILNG------NYRIPELPKYCSSITSLIEEMLQSSPDARPDI 1547 +Y + F E++ I + ++ P +S L+ +ML P R Sbjct: 271 LYILLSGVPPFWAENEKGIFDAILEGVIDFESEPWPSVSNSAKDLVRKMLTQDPRRRITS 330 Query: 1548 TQV----WFR 1565 QV W R Sbjct: 331 AQVLDHPWMR 340
>P39951:CDC2_RAT Cell division control protein 2 homolog - Rattus norvegicus (Rat)| Length = 297 Score = 71.2 bits (173), Expect = 2e-11 Identities = 65/225 (28%), Positives = 100/225 (44%), Gaps = 2/225 (0%) Frame = +3 Query: 777 EAIAEGGFSCVYLARDLTNPAKHYALKHVIVQDKES--LDLVHKEITVMRALKGHPNVVT 950 E I EG + VY R T + A+K + ++ +E +EI++++ L+ HPN+V+ Sbjct: 8 EKIGEGTYGVVYKGRHRTT-GQIVAMKKIRLESEEEGVPSTAIREISLLKELR-HPNIVS 65 Query: 951 LVAHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAMHC 1130 L + D L+ EF L LD+ F D V I + + C Sbjct: 66 LQDVLMQDS----RLYLIFEFLSMDLKKYLDSIPPGQFMDSSLVKSYLYQILQGI--VFC 119 Query: 1131 QTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHTTPAYR 1310 + V HRDLK +N+L+ G KL DFG + F P E + T YR Sbjct: 120 HSRRVLHRDLKPQNLLIDDKGTIKLADFGLA----RAFGIPIRVYTHEVV-----TLWYR 170 Query: 1311 APEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQIL 1445 +PE+ L S VDIW++G + + K F G+S++ L Sbjct: 171 SPEV--LLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQL 213
>P48734:CDC2_BOVIN Cell division control protein 2 homolog - Bos taurus (Bovine)| Length = 297 Score = 71.2 bits (173), Expect = 2e-11 Identities = 65/225 (28%), Positives = 100/225 (44%), Gaps = 2/225 (0%) Frame = +3 Query: 777 EAIAEGGFSCVYLARDLTNPAKHYALKHVIVQDKES--LDLVHKEITVMRALKGHPNVVT 950 E I EG + VY R T + A+K + ++ +E +EI++++ L+ HPN+V+ Sbjct: 8 EKIGEGTYGVVYKGRHKTT-GQVVAMKKIRLESEEEGVPSTAIREISLLKELR-HPNIVS 65 Query: 951 LVAHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAMHC 1130 L + D L+ EF L LD+ F D V I + + C Sbjct: 66 LQDVLMQDS----RLYLIFEFLSMDLKKYLDSIPPGQFMDSSLVKSYLYQILQGI--VFC 119 Query: 1131 QTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHTTPAYR 1310 + V HRDLK +N+L+ G KL DFG + F P E + T YR Sbjct: 120 HSRRVLHRDLKPQNLLIDDKGTIKLADFGLA----RAFGIPIRVYTHEVV-----TLWYR 170 Query: 1311 APEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQIL 1445 +PE+ L S VDIW++G + + K F G+S++ L Sbjct: 171 SPEV--LLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQL 213
>Q6GPL3:AUKBB_XENLA Serine/threonine-protein kinase 12-B - Xenopus laevis (African clawed| frog) Length = 368 Score = 71.2 bits (173), Expect = 2e-11 Identities = 78/292 (26%), Positives = 122/292 (41%), Gaps = 17/292 (5%) Frame = +3 Query: 783 IAEGGFSCVYLARDLTNPAKHYALKHVIVQDKESLDLVH---KEITVMRALKGHPNVVTL 953 + +G F VYLAR+ N ALK + E + H +EI + L+ HPN++ + Sbjct: 106 LGKGKFGNVYLAREKQNKFI-MALKVLFKSQLEKEGVEHQLRREIEIQSHLR-HPNILRM 163 Query: 954 VAHTILDMGRGREALLLMEFCERS-LVSALDARGTAGFYDDEQVALIFRDICNAVFAMHC 1130 + + L++EF R L L G +D+++ A ++ +A+ +C Sbjct: 164 YNY----FHDRKRIYLMLEFAPRGELYKELQKHGR---FDEQRSATFMEELADAL--QYC 214 Query: 1131 QTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHT---TP 1301 V HRD+K EN+L+G G K+ DFG + +R+ T T Sbjct: 215 HERKVIHRDIKPENLLMGYKGELKIADFG--------------WSVHAPSLRRRTMCGTL 260 Query: 1302 AYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFD----GESKLQILNGNYRIPE 1469 Y PEM + EKVD+W G L Y FD E+ +I+N + + P Sbjct: 261 DYLPPEM---IEGKTHDEKVDLWCAGVLCYEFLVGMPPFDSPSHSETHRRIVNVDLKFP- 316 Query: 1470 LPKYCSSITSLIEEMLQSSPDARPDITQV----WFRVN--ELLPLELQKDLP 1607 P LI ++L+ P R + V W + N +LP Q P Sbjct: 317 -PFLSEGSKDLISKLLRYHPAQRLPLKGVMEHPWVKANSRRVLPPVYQSSHP 367
>Q09437:YP62_CAEEL Putative serine/threonine-protein kinase B0495.2 - Caenorhabditis| elegans Length = 719 Score = 70.9 bits (172), Expect = 3e-11 Identities = 68/227 (29%), Positives = 105/227 (46%), Gaps = 8/227 (3%) Frame = +3 Query: 783 IAEGGFSCVYLARDLTNPAKHYALKHVIVQ-DKESLDLVH-KEITVMRALKGHPNVVTLV 956 + EG F VY +D + ALK + ++ +KE + +EI ++ HPN+V + Sbjct: 362 VDEGTFGVVYRGKDKRTD-EIVALKRLKMEKEKEGFPITALREINMLLKAGNHPNIVNV- 419 Query: 957 AHTILDMGRGREALLLMEFCERSLVSALD--ARGTAGFYDDEQVALIFRDICNAVFAMHC 1130 IL + + MEF E + S LD +R F EQ L+ + + + + MH Sbjct: 420 -KEILLGSNMDKIYMAMEFVEHDMKSLLDTMSRRNKRFSIGEQKTLL-QQLLSGIEHMHK 477 Query: 1131 QTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHT----T 1298 + HRDLK N+L+ G K+ DFG E G D ++K T T Sbjct: 478 LW--ILHRDLKTSNLLMSHKGILKIADFGLA----------REYG---DPLKKFTSIVVT 522 Query: 1299 PAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQ 1439 YR+PE+ L + S VD+W++GC+M LK F G +L+ Sbjct: 523 LWYRSPEL--LLGTRLYSTPVDMWSVGCIMAEFILLKPLFPGRGELE 567
>O74456:PEF1_SCHPO Serine/threonine-protein kinase pef1 - Schizosaccharomyces pombe| (Fission yeast) Length = 288 Score = 70.9 bits (172), Expect = 3e-11 Identities = 63/235 (26%), Positives = 107/235 (45%), Gaps = 2/235 (0%) Frame = +3 Query: 777 EAIAEGGFSCVYLARDLTNPAKHYALKHVIVQ-DKESLDLVHKEITVMRALKGHPNVVTL 953 E + EG ++ VY ++ + ALK + + D+ + +EI++M+ L+ HPN+++L Sbjct: 7 EKLGEGTYAHVYKGQNRVT-GEIVALKVIRIDADEGTPSTAIREISLMKELR-HPNIMSL 64 Query: 954 VAHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAMHCQ 1133 +L + +L+ E+ E+ L +D G G QV + + + C Sbjct: 65 --SDVLQTEN--KLMLVFEYMEKDLKKYMDTYGNQGALPPSQVKNFTQQLLKGI--SFCH 118 Query: 1134 TPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKH-TTPAYR 1310 V HRDLK +N+L+ + G KL DFG GI + T YR Sbjct: 119 ENRVLHRDLKPQNLLINSRGELKLADFGLA----------RSIGIPVNTFSNEVVTLWYR 168 Query: 1311 APEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQILNGNYRIPELP 1475 AP++ L V S +DIW++GC+M + + F G + L +R+ P Sbjct: 169 APDV--LLGSRVYSTSIDIWSVGCIMAEMATGRPLFAGSNNEDQLLKIFRLLGTP 221
>P53684:CDPK3_ORYSJ Calcium-dependent protein kinase, isoform 11 - Oryza sativa subsp.| japonica (Rice) Length = 542 Score = 70.9 bits (172), Expect = 3e-11 Identities = 87/308 (28%), Positives = 134/308 (43%), Gaps = 20/308 (6%) Frame = +3 Query: 675 WRPFRQLMPKEHSGPSGGLEGRTIDV-GNVKVHVRE------AIAEGGFSCVYLARDLTN 833 W P S GL+ +I+V G +RE + +G F YL ++ N Sbjct: 42 WPEVNNFKPTAASILRRGLDPTSINVLGRKTADLREHYIIGRKLGQGQFGTTYLCTEI-N 100 Query: 834 PAKHYALKHVIVQD---KESLDLVHKEITVMRALKGHPNVVTLVAHTILDMGRGREAL-L 1001 YA K + + KE ++ V +EI +M L GH NVV I D+ +A+ + Sbjct: 101 TGCEYACKTIPKRKLITKEDVEDVRREIQIMHHLSGHKNVV-----AIKDVYEDGQAVHI 155 Query: 1002 LMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAMHCQTPPVAHRDLKAENVLL 1181 +ME C D G Y + + A + R I + V AM C + V HRDLK EN LL Sbjct: 156 VMELCAGG--ELFDRIQEKGHYSERKAAELIRIIVSIV-AM-CHSLGVMHRDLKPENFLL 211 Query: 1182 ---GADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHTTPAYRAPEMWDLYRREVIS 1352 D + K DFG F KP + + +++ +P Y APE+ L++R Sbjct: 212 LDKDDDLSIKAIDFGL-----SVFFKPGQ--VFTELV---GSPYYVAPEV--LHKR--YG 257 Query: 1353 EKVDIWALGCLMYRICYLKSAFDGESKLQILNG------NYRIPELPKYCSSITSLIEEM 1514 + D+W+ G ++Y + F E++ I + +++ PK S LI +M Sbjct: 258 PESDVWSAGVILYVLLSGVPPFWAETQQGIFDAVLKGHIDFQSDPWPKISDSAKDLIRKM 317 Query: 1515 LQSSPDAR 1538 L P R Sbjct: 318 LSHCPSER 325
>Q9QUK0:CDKL2_MOUSE Cyclin-dependent kinase-like 2 - Mus musculus (Mouse)| Length = 568 Score = 70.9 bits (172), Expect = 3e-11 Identities = 83/326 (25%), Positives = 139/326 (42%), Gaps = 48/326 (14%) Frame = +3 Query: 783 IAEGGFSCVYLARDLTNPAKHYALKHVIVQDKESL--DLVHKEITVMRALKGHPNVVTLV 956 + EG + V R+ + + A+K + D + + + +EI +++ L+ H N+V L+ Sbjct: 10 VGEGSYGMVMKCRN-KDSGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLR-HENLVNLL 67 Query: 957 AHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAMHCQT 1136 + + L+ EF + +++ D + D + V I N + C + Sbjct: 68 EVC----KKKKRWYLVFEFVDHTILD--DLKLFPNGLDYQVVQKYLFQIINGIG--FCHS 119 Query: 1137 PPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHTTPAYRAP 1316 + HRD+K EN+L+ G KLCDFG T P E + D + T YRAP Sbjct: 120 HNIIHRDIKPENILVSQSGVVKLCDFGFART----LAAPGE--VYTDYV---ATRWYRAP 170 Query: 1317 EMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQILN------GN-------- 1454 E+ L + VDIWA+GCL+ + + F GES + L+ GN Sbjct: 171 EL--LVGDVKYGKAVDIWAIGCLVIEMLMGQPLFPGESDIDQLHHIMTCLGNLIPRHQEL 228 Query: 1455 ---------YRIPEL------------PKYCSSITSLIEEMLQSSPDARP---DITQVWF 1562 R+PE+ PK ++ SL ++ L PD RP D+ + F Sbjct: 229 FYKNPVFAGVRLPEVKDAEAEPLESRYPKLPEAVISLAKKCLHIDPDKRPFCADLLRHDF 288 Query: 1563 --------RVNELLPLELQKDLPDGS 1616 R ++ L L+++KD + S Sbjct: 289 FQMDGFAERFSQELQLKIEKDARNNS 314
>P13863:CDC2_CHICK Cell division control protein 2 homolog - Gallus gallus (Chicken)| Length = 303 Score = 70.9 bits (172), Expect = 3e-11 Identities = 64/225 (28%), Positives = 100/225 (44%), Gaps = 2/225 (0%) Frame = +3 Query: 777 EAIAEGGFSCVYLARDLTNPAKHYALKHVIVQDKES--LDLVHKEITVMRALKGHPNVVT 950 E I EG + VY R T + A+K + ++ +E +EI++++ L HPN+V Sbjct: 8 EKIGEGTYGVVYKGRHKTT-GQVVAMKKIRLESEEEGVPSTAIREISLLKELH-HPNIVC 65 Query: 951 LVAHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAMHC 1130 L + D L+ EF L LD + + D +V I + + C Sbjct: 66 LQDVLMQDA----RLYLIFEFLSMDLKKYLDTIPSGQYLDRSRVKSYLYQILQGI--VFC 119 Query: 1131 QTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHTTPAYR 1310 + V HRDLK +N+L+ G KL DFG + F P E + T YR Sbjct: 120 HSRRVLHRDLKPQNLLIDDKGVIKLADFGLA----RAFGIPVRVYTHEVV-----TLWYR 170 Query: 1311 APEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQIL 1445 +PE+ L + S VDIW++G + + K F G+S++ L Sbjct: 171 SPEV--LLGSALYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQL 213
>P35567:CDC2A_XENLA Cell division control protein 2-A - Xenopus laevis (African clawed| frog) Length = 302 Score = 70.9 bits (172), Expect = 3e-11 Identities = 64/225 (28%), Positives = 102/225 (45%), Gaps = 2/225 (0%) Frame = +3 Query: 777 EAIAEGGFSCVYLARDLTNPAKHYALKHVIVQDKES--LDLVHKEITVMRALKGHPNVVT 950 E I EG + VY R + A+K + ++++E +EI++++ L+ HPN+V Sbjct: 8 EKIGEGTYGVVYKGRHKAT-GQVVAMKKIRLENEEEGVPSTAIREISLLKELQ-HPNIVC 65 Query: 951 LVAHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAMHC 1130 L+ + D L+ EF L LD+ + + D V I + + C Sbjct: 66 LLDVLMQDS----RLYLIFEFLSMDLKKYLDSIPSGQYIDTMLVKSYLYQILQGI--VFC 119 Query: 1131 QTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHTTPAYR 1310 + V HRDLK +N+L+ + G KL DFG + F P E + T YR Sbjct: 120 HSRRVLHRDLKPQNLLIDSKGVIKLADFGLA----RAFGIPVRVYTHEVV-----TLWYR 170 Query: 1311 APEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQIL 1445 APE+ L S VD+W++G + I K F G+S++ L Sbjct: 171 APEV--LLGSVRYSTPVDVWSIGTIFAEIATKKPLFHGDSEIDQL 213
>O70126:AURKB_MOUSE Serine/threonine-protein kinase 12 - Mus musculus (Mouse)| Length = 345 Score = 70.9 bits (172), Expect = 3e-11 Identities = 77/278 (27%), Positives = 123/278 (44%), Gaps = 15/278 (5%) Frame = +3 Query: 783 IAEGGFSCVYLARDLTNPAKHYALKHVIVQDKESLDLVH---KEITVMRALKGHPNVVTL 953 + +G F VYLAR+ + ALK + E + H +EI + LK HPN++ L Sbjct: 88 LGKGKFGNVYLAREKKSRFI-VALKILFKSQIEKEGVEHQLRREIEIQAHLK-HPNILQL 145 Query: 954 VAHTILDMGRGREALLLMEFCERS-LVSALDARGTAGFYDDEQVALIFRDICNAVFAMHC 1130 + D R L++E+ R L L T +D+++ A I ++ +A+ +C Sbjct: 146 YNY-FYDQQR---IYLILEYAPRGELYKELQKSRT---FDEQRTATIMEELSDAL--TYC 196 Query: 1131 QTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHT---TP 1301 V HRD+K EN+LLG G K+ DFG + +R+ T T Sbjct: 197 HKKKVIHRDIKPENLLLGLQGELKIADFG--------------WSVHAPSLRRKTMCGTL 242 Query: 1302 AYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQILNGNYRIPELPKY 1481 Y PEM + +E VD+W +G L Y + F+ S + ++ K+ Sbjct: 243 DYLPPEM---IEGRMHNEMVDLWCIGVLCYELMVGNPPFESPSHSETYRRIVKVD--LKF 297 Query: 1482 CSSITS----LIEEMLQSSPDARPDITQV----WFRVN 1571 SS+ S LI ++L+ +P R + +V W R N Sbjct: 298 PSSVPSGAQDLISKLLKHNPWQRLPLAEVAAHPWVRAN 335
>Q2VWQ3:STE20_PENMA Serine/threonine-protein kinase pakA - Penicillium marneffei| Length = 642 Score = 70.5 bits (171), Expect = 4e-11 Identities = 67/257 (26%), Positives = 115/257 (44%), Gaps = 5/257 (1%) Frame = +3 Query: 783 IAEGGFSCVYLARDLTNPAKHYALKHVIVQDKESLDLVHKEITVMRALKGHPNVVTLVAH 962 I +G V+ A + TN K A+K + + + DL+ EI VM+ K H N+V + Sbjct: 367 IGQGASGGVFTAYE-TNTNKCVAIKQMNLDLQPKKDLIINEILVMKDSK-HKNIVNFLDS 424 Query: 963 TILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAMHCQTPP 1142 + G + ++ME+ E ++ + T + Q+A + R+ + + H + Sbjct: 425 YL----HGLDLWVVMEYMEGGSLTDVV---TFNIMSEGQIAAVCRETLSGL--QHLHSKG 475 Query: 1143 VAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHTTPAYRAPEM 1322 V HRD+K++N+LL DG KL DFG C + + ++ TP + APE Sbjct: 476 VIHRDIKSDNILLSMDGEIKLTDFGF------CAQINDSQNKRNTMV---GTPYWMAPE- 525 Query: 1323 WDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQIL-----NGNYRIPELPKYCS 1487 + R+ KVDIW+LG + + + + ES L+ L NG +I + Sbjct: 526 --VVTRKEYGRKVDIWSLGIMAIEMIEGEPPYLTESPLRALYLIATNGTPKIKDEQNLSP 583 Query: 1488 SITSLIEEMLQSSPDAR 1538 + L+ P+ R Sbjct: 584 VFRDFLHLALRVDPEKR 600
>Q84TC6:SAPK2_ORYSA Serine/threonine-protein kinase SAPK2 - Oryza sativa (Rice)| Length = 339 Score = 70.5 bits (171), Expect = 4e-11 Identities = 72/291 (24%), Positives = 129/291 (44%), Gaps = 14/291 (4%) Frame = +3 Query: 762 KVHVREAIAEGGFSCVYLARDLTNPAKHYALKHVIVQDKESLDLVHKEITVMRALKGHPN 941 + V + I G F L RD+ + +A+K I + ++ + V +EI R+L+ HPN Sbjct: 3 RYEVIKDIGSGNFGVAKLVRDVRTK-ELFAVKF-IERGQKIDENVQREIMNHRSLR-HPN 59 Query: 942 VVTLVAHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFA 1121 +V + ++ME+ + +AG + +++ F+ + + V Sbjct: 60 IVRFKEVVLTPT----HLAIVMEYAAGG--ELFERICSAGRFSEDEARFFFQQLISGV-- 111 Query: 1122 MHCQTPPVAHRDLKAENVLLGADGA--WKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHT 1295 +C + + HRDLK EN LL A K+CDFG S + +P+ Sbjct: 112 SYCHSMQICHRDLKLENTLLDGSIAPRLKICDFG-YSKSSLLHSQPKS---------TVG 161 Query: 1296 TPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESK--------LQILNG 1451 TPAY APE+ L R+E + D+W+ G +Y + F+ + +IL+ Sbjct: 162 TPAYIAPEV--LARKEYDGKVADVWSCGVTLYVMLVGAYPFEDPDEPRNFRKTITRILSV 219 Query: 1452 NYRIPELPKYCSSITSLIEEMLQSSPDARPDITQV----WFRVNELLPLEL 1592 Y +P+ + L+ + ++P+ R I ++ WF N LP+E+ Sbjct: 220 QYMVPDYVRVSMECRHLLSRIFVANPEQRITIPEIKNHPWFLKN--LPIEM 268
>Q9URY1:PPK16_SCHPO Serine/threonine-protein kinase ppk16 - Schizosaccharomyces pombe| (Fission yeast) Length = 672 Score = 70.5 bits (171), Expect = 4e-11 Identities = 78/280 (27%), Positives = 123/280 (43%), Gaps = 7/280 (2%) Frame = +3 Query: 738 RTIDVGNVKVHVREAIAEGGFSCVYLARDLTNPAKHYALKHVIVQD--KESLDLVHKEIT 911 R DVG ++ + EG F VYLA L K V+++ ++ ++ +EI Sbjct: 24 RISDVGTYRIE--SVVGEGSFGKVYLAAHLLTNTK------VVLKSSCRKQAIILAREIH 75 Query: 912 VMRALKGHPNVVTLVAHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALI 1091 R L HPN+ L + L ME+C + AR D++ I Sbjct: 76 HHRRLL-HPNITRLYEVVCTE----DRIYLAMEYCPNGELYDWVAREKR--LDEKTTCRI 128 Query: 1092 FRDICNAVFAMHCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIE 1271 +C A+ +H Q HRDLK EN+ L KL DFG F + + Sbjct: 129 MWQLCCAIQYLHRQG--CVHRDLKLENIFLDKAYNVKLGDFG--------FSRDSDCSRR 178 Query: 1272 EDIIRKHTTPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGE----SKLQ 1439 + + T AY APE+ + + I E VDIW+LG +MY + + FD + ++ + Sbjct: 179 TFMNTRCGTVAYCAPEL--VQGHKYIGECVDIWSLGIIMYALLIGRLPFDEDDVSLTEQK 236 Query: 1440 ILNGNYRIPELPKYCS-SITSLIEEMLQSSPDARPDITQV 1556 I+N P+ P+ S + +SL++ +L RP I Q+ Sbjct: 237 IIN---ECPQYPETLSKNSSSLLKSLLCKDYRLRPSIDQI 273
>P50528:PLO1_SCHPO Serine/threonine-protein kinase plo1 - Schizosaccharomyces pombe| (Fission yeast) Length = 683 Score = 70.5 bits (171), Expect = 4e-11 Identities = 88/308 (28%), Positives = 132/308 (42%), Gaps = 21/308 (6%) Frame = +3 Query: 777 EAIAEGGFSCVYLARDLTNPAKHYALKHV----IVQDKESLDLVHKEITVMRALKGHPNV 944 + I EGGF+ + +D N YA K + + DK L L EI V +++ HPN+ Sbjct: 45 DCIGEGGFARCFRVKD--NYGNIYAAKVIAKRSLQNDKTKLKLFG-EIKVHQSMS-HPNI 100 Query: 945 VTLVAHTILDMGRGREALLLMEFCE-RSLVSALDARGTAGFYDDEQVALIFRDICNAVFA 1121 V + L++E CE +SL+ L R + +V + I A+ Sbjct: 101 VGFIDC----FEDSTNIYLILELCEHKSLMELLRKRKQL---TEPEVRYLMMQILGALKY 153 Query: 1122 MHCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHT-- 1295 MH + V HRDLK N++L K+ DFG + + +D RK T Sbjct: 154 MHKKR--VIHRDLKLGNIMLDESNNVKIGDFGLAAL------------LMDDEERKMTIC 199 Query: 1296 -TPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAF-DGESKL---QILNGNYR 1460 TP Y APE+ +E S +VD+W+ G +MY + K F D E K +I +Y Sbjct: 200 GTPNYIAPEIL-FNSKEGHSFEVDLWSAGVVMYALLIGKPPFQDKEVKTIYRKIKANSYS 258 Query: 1461 IPELPKYCSSITSLIEEMLQSSPDARPDITQV----WFRVNEL---LPLELQKDLP--DG 1613 P + LI +L P RP I + +F + LP E+ +P Sbjct: 259 FPSNVDISAEAKDLISSLLTHDPSIRPSIDDIVDHEFFHTGYMASTLPDEILHSMPIWPS 318 Query: 1614 SPSGSAFE 1637 S S S+F+ Sbjct: 319 SQSKSSFQ 326
>P34331:PLK1_CAEEL Serine/threonine-protein kinase plk-1 - Caenorhabditis elegans| Length = 649 Score = 70.5 bits (171), Expect = 4e-11 Identities = 76/271 (28%), Positives = 121/271 (44%), Gaps = 13/271 (4%) Frame = +3 Query: 783 IAEGGFSCVYLARDLTNPAKHYAL------KHVIVQDKESLDLVHKEITVMRALKGHPNV 944 + +GGF+ Y +LTN A + K ++V+ + + ++ I + R L GH N+ Sbjct: 44 LGKGGFAHCY---ELTNRATREVVAGKVVPKSMLVKQYQRDKVDNERILIHREL-GHINI 99 Query: 945 VTLVAHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAM 1124 V L ++ + +E C R + L R A + + I + V + Sbjct: 100 VKLFNFFEDNLN----VYITLELCARRSLMELHKRRKA--VTEPEARYFTHQIVDGVLYL 153 Query: 1125 HCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHT--- 1295 H + HRD+K N+ L D K+ DFG +T + G E RK T Sbjct: 154 HDLN--IIHRDMKLGNLFLNDDLVVKIGDFGLATTVN---------GDE----RKKTLCG 198 Query: 1296 TPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDG----ESKLQILNGNYRI 1463 TP Y APE+ + + S +VDIWA+GC++Y + + + F+ E+ +I + NY I Sbjct: 199 TPNYIAPEVLN---KAGHSFEVDIWAVGCILYILLFGQPPFESKSLEETYSRIRHNNYTI 255 Query: 1464 PELPKYCSSITSLIEEMLQSSPDARPDITQV 1556 P + SLI +ML P RP QV Sbjct: 256 PSIA--TQPAASLIRKMLDPEPTRRPTAKQV 284
>Q2TA25:PLK1_BOVIN Serine/threonine-protein kinase PLK1 - Bos taurus (Bovine)| Length = 602 Score = 70.5 bits (171), Expect = 4e-11 Identities = 62/194 (31%), Positives = 93/194 (47%), Gaps = 8/194 (4%) Frame = +3 Query: 999 LLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAMHCQTPPVAHRDLKAENVL 1178 +++E C R + L R A + + R I +H V HRDLK N+ Sbjct: 126 VVLELCRRRSLLELHKRRKA--LTEPEARYYLRQIVLGCQYLHGNR--VIHRDLKLGNLF 181 Query: 1179 LGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHT---TPAYRAPEMWDLYRREVI 1349 L D K+ DFG + +E D RK T TP Y APE+ ++ Sbjct: 182 LNEDLEVKIGDFGLATK------------VEYDGERKKTLCGTPNYIAPEVLS---KKGH 226 Query: 1350 SEKVDIWALGCLMYRICYLKSAFD----GESKLQILNGNYRIPELPKYCSSI-TSLIEEM 1514 S +VD+W++GC+MY + K F+ E+ L+I N Y I PK+ + + +SLI++M Sbjct: 227 SFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKNNEYSI---PKHINPVASSLIKKM 283 Query: 1515 LQSSPDARPDITQV 1556 LQ P ARP I ++ Sbjct: 284 LQPDPTARPTIHEL 297
>P36005:KKQ1_YEAST Probable serine/threonine-protein kinase YKL161C - Saccharomyces| cerevisiae (Baker's yeast) Length = 433 Score = 70.5 bits (171), Expect = 4e-11 Identities = 66/240 (27%), Positives = 110/240 (45%), Gaps = 9/240 (3%) Frame = +3 Query: 756 NVKVHVREAIAEGGFSCVYLARDL-TNPAKHYALKHV--IVQDKESLDLVHKEITVMRAL 926 N H+ I G S + + +N H A++ + +K S +E+ ++R L Sbjct: 20 NKHFHLTGKIGRGSHSLICSSTYTESNEETHVAIRKIPNAFGNKLSCKRTLRELKLLRHL 79 Query: 927 KGHPNVVTLVAHTILDMGRG--REALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRD 1100 +GHPN+V L I+ G L E E L + R D + I++ Sbjct: 80 RGHPNIVWLFDTDIVFYPNGALNGVYLYEELMECDLSQII--RSEQRLEDAHFQSFIYQI 137 Query: 1101 ICNAVFAMHCQTPPVAHRDLKAENVLLGADGAWKLCDFG---SVSTNHKCFDKPEERGIE 1271 +C A+ +H V H DLK +N+L+ +D K+C+FG S S NHK + Sbjct: 138 LC-ALKYIHSAN--VLHCDLKPKNLLVNSDCQLKICNFGLSCSYSENHK---------VN 185 Query: 1272 EDIIRKHTTPA-YRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQILN 1448 + I+ + T Y+APE+ L + ++ VDIW+ GC++ + K F+G+ + LN Sbjct: 186 DGFIKGYITSIWYKAPEI--LLNYQECTKAVDIWSTGCILAELLGRKPMFEGKDYVDHLN 243
>P38692:KIC1_YEAST Serine/threonine-protein kinase KIC1 - Saccharomyces cerevisiae| (Baker's yeast) Length = 1080 Score = 70.5 bits (171), Expect = 4e-11 Identities = 72/288 (25%), Positives = 121/288 (42%), Gaps = 12/288 (4%) Frame = +3 Query: 777 EAIAEGGFSCVYLARDLTNPAKHYALKHV-IVQDKESLDLVHKEITVMRALKGHPNVVTL 953 E I G F VY ++ + YA+K + + D + ++ V +EI + +LK N+ Sbjct: 27 EVIGRGKFGVVYKGYNVKT-GRVYAIKVLNLDSDSDEVEDVQREIQFLASLKQISNITRY 85 Query: 954 VAHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAMHCQ 1133 + D ++ME C + +L G D++ + +I R++ A+ +H Sbjct: 86 YGSYLKDTS----LWIIMEHCAGGSLRSLLRPGKI---DEKYIGVIMRELLVALKCIHKD 138 Query: 1134 TPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHT---TPA 1304 V HRD+KA NVL+ +G KLCDFG + + + +R+ T TP Sbjct: 139 N--VIHRDIKAANVLITNEGNVKLCDFGVAAQ------------VNQTSLRRQTMAGTPY 184 Query: 1305 YRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQ----ILNGNYRIPEL 1472 + APE+ + KVDIW+LG Y I + L+ I+ E Sbjct: 185 WMAPEV--IMEGVYYDTKVDIWSLGITTYEIATGNPPYCDVEALRAMQLIIKSKPPRLED 242 Query: 1473 PKYCSSITSLIEEMLQSSPDARPD----ITQVWFRVNELLPLELQKDL 1604 Y +S+ I L P R + + R ++ P + K+L Sbjct: 243 RSYSTSLKEFIALCLDEDPKERLSADDLLKSKFIRAHKATPTSILKEL 290
>P97377:CDK2_MOUSE Cell division protein kinase 2 - Mus musculus (Mouse)| Length = 346 Score = 70.5 bits (171), Expect = 4e-11 Identities = 66/215 (30%), Positives = 101/215 (46%), Gaps = 7/215 (3%) Frame = +3 Query: 777 EAIAEGGFSCVYLARDLTNPAKHYALKHVIVQDKES--LDLVHKEITVMRALKGHPNVVT 950 E I EG + VY A++ + ALK + + + +EI++++ L HPN+V Sbjct: 8 EKIGEGTYGVVYKAKNKLT-GEVVALKKIRLDTETEGVPSTAIREISLLKELN-HPNIVK 65 Query: 951 L--VAHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAM 1124 L V HT + L+ EF + L +DA G + +F+ + F Sbjct: 66 LLDVIHT------ENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAF-- 117 Query: 1125 HCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHTTPA 1304 C + V HRDLK +N+L+ A+G+ KL DFG + F P E + T Sbjct: 118 -CHSHRVLHRDLKPQNLLINAEGSIKLADFGLA----RAFGVPVRTYTHEVV-----TLW 167 Query: 1305 YRAPEMWDLYRREVISEKVDIWALGCL---MYRIC 1400 YRAPE+ L + S VDIW+LGC+ M+ +C Sbjct: 168 YRAPEI--LLGCKYYSTAVDIWSLGCIFAEMHLVC 200
>Q6DE08:AUKBA_XENLA Serine/threonine-protein kinase 12-A - Xenopus laevis (African clawed| frog) Length = 361 Score = 70.5 bits (171), Expect = 4e-11 Identities = 74/278 (26%), Positives = 117/278 (42%), Gaps = 15/278 (5%) Frame = +3 Query: 783 IAEGGFSCVYLARDLTNPAKHYALKHVIVQDKESLDLVH---KEITVMRALKGHPNVVTL 953 + +G F VYLAR+ N ALK + E + H +EI + L+ HPN++ + Sbjct: 99 LGKGKFGNVYLAREKQNKFI-MALKVLFKSQLEKEGVEHQLRREIEIQSHLR-HPNILRM 156 Query: 954 VAHTILDMGRGREALLLMEFCERS-LVSALDARGTAGFYDDEQVALIFRDICNAVFAMHC 1130 + + L++EF R L L G +D+++ A ++ +A+ +C Sbjct: 157 YNY----FHDRKRIYLMLEFAPRGELYKELQKHGR---FDEQRSATFMEELADALH--YC 207 Query: 1131 QTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHT---TP 1301 V HRD+K EN+L+G G K+ DFG + +R+ T T Sbjct: 208 HERKVIHRDIKPENLLMGYKGELKIADFG--------------WSVHAPSLRRRTMCGTL 253 Query: 1302 AYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDG----ESKLQILNGNYRIPE 1469 Y PEM + EKVD+W G L Y FD E+ +I+N + + P Sbjct: 254 DYLPPEM---IEGKTHDEKVDLWCAGVLCYEFLVGMPPFDSPSHTETHRRIVNVDLKFP- 309 Query: 1470 LPKYCSSITSLIEEMLQSSPDARPDITQV----WFRVN 1571 P LI ++L+ P R + V W + N Sbjct: 310 -PFLSDGSKDLISKLLRYHPPQRLPLKGVMEHPWVKAN 346
>Q02066:AAIP_WHEAT Abscisic acid-inducible protein kinase - Triticum aestivum (Wheat)| Length = 332 Score = 70.5 bits (171), Expect = 4e-11 Identities = 76/287 (26%), Positives = 119/287 (41%), Gaps = 20/287 (6%) Frame = +3 Query: 792 GGFSCVYLARDLTNPAKHYALKHVIVQDKESLDLVHKEITVMRALKGHPN------VVTL 953 G F L RD+ +H+A+K + K + V +EI R+LK HPN VV Sbjct: 3 GNFGVAKLVRDVRTK-EHFAVKFIERGHKID-EHVQREIMNHRSLK-HPNIIRFKEVVLT 59 Query: 954 VAHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAMHCQ 1133 H + M L C AG + +++ F+ + + V +C Sbjct: 60 PTHLAIVMEYASGGELFQRICN------------AGRFSEDEGRFFFQQLISGV--SYCH 105 Query: 1134 TPPVAHRDLKAENVLLGADGA--WKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHTTPAY 1307 + V HRDLK EN LL A K+CDFG S + +P+ TPAY Sbjct: 106 SMQVCHRDLKLENTLLDGSVAPRLKICDFG-YSKSSVLHSQPKS---------TVGTPAY 155 Query: 1308 RAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESK--------LQILNGNYRI 1463 APE+ L RRE + D+W+ G +Y + F+ + +IL+ Y + Sbjct: 156 IAPEV--LSRREYDGKVADVWSCGVTLYVMLVGAYPFEDPDEPRNFRKTITRILSVQYSV 213 Query: 1464 PELPKYCSSITSLIEEMLQSSPDARPDITQV----WFRVNELLPLEL 1592 P+ + L+ + +P R I ++ WF + LP+E+ Sbjct: 214 PDYVRVSMDCIHLLSRIFVGNPQQRITIPEIKNHPWFL--KRLPVEM 258
>Q2TA06:STK6_BOVIN Serine/threonine-protein kinase 6 - Bos taurus (Bovine)| Length = 402 Score = 70.1 bits (170), Expect = 5e-11 Identities = 68/266 (25%), Positives = 113/266 (42%), Gaps = 8/266 (3%) Frame = +3 Query: 783 IAEGGFSCVYLARDLTNPAKHYALKHVIVQDKESLDLVH---KEITVMRALKGHPNVVTL 953 + +G F VYLAR+ + ALK + E + H +E+ + L+ HPN++ L Sbjct: 139 LGKGKFGNVYLAREKQSKFI-LALKVLFKAQLEKAGVEHQLRREVEIQSHLR-HPNILRL 196 Query: 954 VAHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAMHCQ 1133 + L++E+ L + +D+++ A ++ NA+ +C Sbjct: 197 YGY----FHDATRVYLILEYAP--LGAVYRELQKLSKFDEQRTATYITELANAL--SYCH 248 Query: 1134 TPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHT---TPA 1304 + V HRD+K EN+LLG+ G K+ DFG + R+ T T Sbjct: 249 SKRVIHRDIKPENLLLGSAGELKIADFG--------------WSVHAPSSRRTTLCGTLD 294 Query: 1305 YRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQILNGNYRIPELPKYC 1484 Y PEM + EKVD+W+LG L Y K F+ ++ + R+ C Sbjct: 295 YLPPEM---IEGRMHDEKVDLWSLGVLCYEFLVGKPPFEADTYQETYRRISRVEFTFPDC 351 Query: 1485 --SSITSLIEEMLQSSPDARPDITQV 1556 LI +L+ +P RP + +V Sbjct: 352 VPEGARDLISRLLKHNPSQRPTLKEV 377
>Q03306:PKH3_YEAST Serine/threonine-protein kinase PKH3 - Saccharomyces cerevisiae| (Baker's yeast) Length = 898 Score = 70.1 bits (170), Expect = 5e-11 Identities = 64/243 (26%), Positives = 101/243 (41%), Gaps = 21/243 (8%) Frame = +3 Query: 774 REAIAEGGFSCVYLARDLTNPAKHYALK-----HVIVQDKESLDLVHKEITVMRALKGHP 938 +E + G +S V+ A D +P K YA+K H+I + K + K + A K H Sbjct: 14 KEELGHGSYSTVFKALDKKSPNKIYAIKVCSKKHIIKEAKVKYVTIEKNTMNLLAQKHHA 73 Query: 939 NVVTLV--------AHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIF 1094 ++ L + +LD G E L L+ G ++D Sbjct: 74 GIIKLYYTFHDEENLYFVLDFAPGGELLSLLH--------------KMGTFNDIWTRHFT 119 Query: 1095 RDICNAVFAMHCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEE 1274 + +A+ +H + HRDLK ENVLL DG + DFG+ +T + + Sbjct: 120 AQLIDALEFIHSHG--IIHRDLKPENVLLDRDGRLMITDFGAAATIDPSLSGDSAKFNSD 177 Query: 1275 DIIRKHT--------TPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGES 1430 K T Y +PE+ LY + DIWALGC++Y+ + F GE+ Sbjct: 178 SNGSKDNQNCASFVGTAEYVSPELL-LYNQ--CGYGSDIWALGCMIYQFVQGQPPFRGEN 234 Query: 1431 KLQ 1439 +L+ Sbjct: 235 ELK 237
>P31325:PHKG2_RAT Phosphorylase b kinase gamma catalytic chain, testis/liver isoform -| Rattus norvegicus (Rat) Length = 406 Score = 70.1 bits (170), Expect = 5e-11 Identities = 67/239 (28%), Positives = 107/239 (44%), Gaps = 16/239 (6%) Frame = +3 Query: 870 QDKESLDLVHKEITVMRALKGHPNVVTLVAHTILDMGRGREALLLMEFCERSLVSALDAR 1049 Q +E D +E+ ++R + GHP+++TL+ E+ M LV L + Sbjct: 66 QLEEVRDATRREMHILRQVAGHPHIITLID--------SYESSSFM-----FLVFDLMRK 112 Query: 1050 GTAGFYDDEQVAL-------IFRDICNAVFAMHCQTPPVAHRDLKAENVLLGADGAWKLC 1208 G Y E+VAL I R + AV +H + HRDLK EN+LL + +L Sbjct: 113 GELFDYLTEKVALSEKETRSIMRSLLEAVNFLHVNN--IVHRDLKPENILLDDNMQIRLS 170 Query: 1209 DFGSVSTNHKCFDKPEERGIEEDIIRKHTTPAYRAPEMWDLYRREV---ISEKVDIWALG 1379 DFG C +P E+ + TP Y APE+ E ++VD+WA G Sbjct: 171 DFG-----FSCHLEPGEK-----LRELCGTPGYLAPEILKCSMDETHPGYGKEVDLWACG 220 Query: 1380 CLMYRICYLKSAFDGESKL----QILNGNYRI--PELPKYCSSITSLIEEMLQSSPDAR 1538 +++ + F ++ I+ G Y+ PE +++ LI ++LQ P+AR Sbjct: 221 VILFTLLAGSPPFWHRRQILMLRMIMEGQYQFSSPEWDDRSNTVKDLIAKLLQVDPNAR 279
>Q9DB30:PHKG2_MOUSE Phosphorylase b kinase gamma catalytic chain, testis/liver isoform -| Mus musculus (Mouse) Length = 406 Score = 70.1 bits (170), Expect = 5e-11 Identities = 68/239 (28%), Positives = 106/239 (44%), Gaps = 16/239 (6%) Frame = +3 Query: 870 QDKESLDLVHKEITVMRALKGHPNVVTLVAHTILDMGRGREALLLMEFCERSLVSALDAR 1049 Q +E D +E+ ++R + GHP+++TL+ E+ M LV L + Sbjct: 66 QLEEVRDATRREMHILRQVAGHPHIITLID--------SYESSSFM-----FLVFDLMRK 112 Query: 1050 GTAGFYDDEQVAL-------IFRDICNAVFAMHCQTPPVAHRDLKAENVLLGADGAWKLC 1208 G Y E+VAL I R + AV +H + HRDLK EN+LL + +L Sbjct: 113 GELFDYLTEKVALSEKETRSIMRSLLEAVSFLHANN--IVHRDLKPENILLDDNMQIRLS 170 Query: 1209 DFGSVSTNHKCFDKPEERGIEEDIIRKHTTPAYRAPEMWDLYRREV---ISEKVDIWALG 1379 DFG F E G E + TP Y APE+ E ++VD+WA G Sbjct: 171 DFG--------FSCHLEAG--EKLRELCGTPGYLAPEILKCSMDETHPGYGKEVDLWACG 220 Query: 1380 CLMYRICYLKSAFDGESKL----QILNGNYRI--PELPKYCSSITSLIEEMLQSSPDAR 1538 +++ + F ++ I+ G Y+ PE +++ LI ++LQ P+AR Sbjct: 221 VILFTLLAGSPPFWHRRQILMLRMIMEGQYQFTSPEWDDCSNTVKDLISKLLQVDPEAR 279
>P15735:PHKG2_HUMAN Phosphorylase b kinase gamma catalytic chain, testis/liver isoform -| Homo sapiens (Human) Length = 406 Score = 70.1 bits (170), Expect = 5e-11 Identities = 67/239 (28%), Positives = 105/239 (43%), Gaps = 16/239 (6%) Frame = +3 Query: 870 QDKESLDLVHKEITVMRALKGHPNVVTLVAHTILDMGRGREALLLMEFCERSLVSALDAR 1049 Q +E + +E ++R + GHP+++TL+ E+ M LV L + Sbjct: 66 QLEEVREATRRETHILRQVAGHPHIITLID--------SYESSSFM-----FLVFDLMRK 112 Query: 1050 GTAGFYDDEQVAL-------IFRDICNAVFAMHCQTPPVAHRDLKAENVLLGADGAWKLC 1208 G Y E+VAL I R + AV +H + HRDLK EN+LL + +L Sbjct: 113 GELFDYLTEKVALSEKETRSIMRSLLEAVSFLHANN--IVHRDLKPENILLDDNMQIRLS 170 Query: 1209 DFGSVSTNHKCFDKPEERGIEEDIIRKHTTPAYRAPEMWDLYRREV---ISEKVDIWALG 1379 DFG C +P E+ + TP Y APE+ E ++VD+WA G Sbjct: 171 DFG-----FSCHLEPGEK-----LRELCGTPGYLAPEILKCSMDETHPGYGKEVDLWACG 220 Query: 1380 CLMYRICYLKSAFDGESKL----QILNGNYRI--PELPKYCSSITSLIEEMLQSSPDAR 1538 +++ + F ++ I+ G Y+ PE S++ LI +LQ P+AR Sbjct: 221 VILFTLLAGSPPFWHRRQILMLRMIMEGQYQFSSPEWDDRSSTVKDLISRLLQVDPEAR 279
>Q9TTK0:CDKL2_RABIT Cyclin-dependent kinase-like 2 - Oryctolagus cuniculus (Rabbit)| Length = 566 Score = 70.1 bits (170), Expect = 5e-11 Identities = 78/319 (24%), Positives = 133/319 (41%), Gaps = 46/319 (14%) Frame = +3 Query: 783 IAEGGFSCVYLARDLTNPAKHYALKHVIVQDKESL--DLVHKEITVMRALKGHPNVVTLV 956 + EG + V R+ + + A+K + D + + + +EI +++ L+ H N+V L+ Sbjct: 10 VGEGSYGMVMKCRN-KDSGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLR-HENLVNLL 67 Query: 957 AHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAMHCQT 1136 + + L+ EF + +++ L+ DD+ V I N + C + Sbjct: 68 EVC----KKKKRWYLVFEFVDHTILDDLELFPNG--LDDQVVQKYLFQIINGIG--FCHS 119 Query: 1137 PPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHTTPAYRAP 1316 + HRD+K EN+L+ G KLCDFG T P E + D + T YRAP Sbjct: 120 HNIIHRDIKPENILVSQSGVVKLCDFGFART----LAAPGE--VYTDYV---ATRWYRAP 170 Query: 1317 EMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQILN------GN-------- 1454 E+ L + VD+WA+GCL+ + + F G+S + L GN Sbjct: 171 EL--LVGDVKYGKAVDVWAIGCLVTEMLMGEPLFPGDSDIDQLYLIMRCLGNLIPRHQEL 228 Query: 1455 ---------YRIPEL----------PKYCSSITSLIEEMLQSSPDARPDITQVWF----- 1562 R+PE+ PK + L ++ L PD RP ++ Sbjct: 229 FYKNPVFAGVRLPEIKESEPLERRYPKLSEVVIDLAKKCLHVDPDKRPFCAELLHHDFFQ 288 Query: 1563 ------RVNELLPLELQKD 1601 R ++ L +++QKD Sbjct: 289 MDGFAERFSQELQMKVQKD 307
>P11440:CDC2_MOUSE Cell division control protein 2 homolog - Mus musculus (Mouse)| Length = 297 Score = 70.1 bits (170), Expect = 5e-11 Identities = 64/225 (28%), Positives = 99/225 (44%), Gaps = 2/225 (0%) Frame = +3 Query: 777 EAIAEGGFSCVYLARDLTNPAKHYALKHVIVQDKES--LDLVHKEITVMRALKGHPNVVT 950 E I EG + VY R + A+K + ++ +E +EI++++ L+ HPN+V+ Sbjct: 8 EKIGEGTYGVVYKGRHRVT-GQIVAMKKIRLESEEEGVPSTAIREISLLKELR-HPNIVS 65 Query: 951 LVAHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAMHC 1130 L + D L+ EF L LD+ F D V I + + C Sbjct: 66 LQDVLMQDS----RLYLIFEFLSMDLKKYLDSIPPGQFMDSSLVKSYLHQILQGI--VFC 119 Query: 1131 QTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHTTPAYR 1310 + V HRDLK +N+L+ G KL DFG + F P E + T YR Sbjct: 120 HSRRVLHRDLKPQNLLIDDKGTIKLADFGLA----RAFGIPIRVYTHEVV-----TLWYR 170 Query: 1311 APEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQIL 1445 +PE+ L S VDIW++G + + K F G+S++ L Sbjct: 171 SPEV--LLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQL 213
>P06493:CDC2_HUMAN Cell division control protein 2 homolog - Homo sapiens (Human)| Length = 297 Score = 70.1 bits (170), Expect = 5e-11 Identities = 64/225 (28%), Positives = 100/225 (44%), Gaps = 2/225 (0%) Frame = +3 Query: 777 EAIAEGGFSCVYLARDLTNPAKHYALKHVIVQDKES--LDLVHKEITVMRALKGHPNVVT 950 E I EG + VY R T + A+K + ++ +E +EI++++ L+ HPN+V+ Sbjct: 8 EKIGEGTYGVVYKGRHKTT-GQVVAMKKIRLESEEEGVPSTAIREISLLKELR-HPNIVS 65 Query: 951 LVAHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAMHC 1130 L + D L+ EF L LD+ + D V I + + C Sbjct: 66 LQDVLMQDS----RLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGI--VFC 119 Query: 1131 QTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHTTPAYR 1310 + V HRDLK +N+L+ G KL DFG + F P E + T YR Sbjct: 120 HSRRVLHRDLKPQNLLIDDKGTIKLADFGLA----RAFGIPIRVYTHEVV-----TLWYR 170 Query: 1311 APEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQIL 1445 +PE+ L S VDIW++G + + K F G+S++ L Sbjct: 171 SPEV--LLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQL 213
>P23572:CDC2_DROME Cell division control protein 2 homolog - Drosophila melanogaster| (Fruit fly) Length = 297 Score = 70.1 bits (170), Expect = 5e-11 Identities = 67/235 (28%), Positives = 107/235 (45%), Gaps = 2/235 (0%) Frame = +3 Query: 777 EAIAEGGFSCVYLARDLTNPAKHYALKHVIVQ--DKESLDLVHKEITVMRALKGHPNVVT 950 E I EG + VY R+ + A+K + ++ D+ +EI++++ LK H N+V Sbjct: 8 EKIGEGTYGVVYKGRNRLT-GQIVAMKKIRLESDDEGVPSTAIREISLLKELK-HENIVC 65 Query: 951 LVAHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAMHC 1130 L +++ R L+ EF L +D+ + E V I +A+ + C Sbjct: 66 L-EDVLMEENR---IYLIFEFLSMDLKKYMDSLPVDKHMESELVRSYLYQITSAI--LFC 119 Query: 1131 QTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHTTPAYR 1310 V HRDLK +N+L+ G K+ DFG + F P E + T YR Sbjct: 120 HRRRVLHRDLKPQNLLIDKSGLIKVADFGL----GRSFGIPVRIYTHEIV-----TLWYR 170 Query: 1311 APEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQILNGNYRIPELP 1475 APE+ L S VDIW++GC+ + K F G+S++ L +RI + P Sbjct: 171 APEV--LLGSPRYSCPVDIWSIGCIFAEMATRKPLFQGDSEIDQLFRMFRILKTP 223
>Q4Z6R1:CDC2H_PLABA Cell division control protein 2 homolog - Plasmodium berghei (strain| Anka) Length = 288 Score = 70.1 bits (170), Expect = 5e-11 Identities = 64/241 (26%), Positives = 112/241 (46%), Gaps = 3/241 (1%) Frame = +3 Query: 762 KVHVREAIAEGGFSCVYLARDLTNPAKHYALKHVIVQ--DKESLDLVHKEITVMRALKGH 935 K H E I EG + VY A++ + + +ALK + ++ D+ +EI++++ L+ H Sbjct: 3 KYHGLEKIGEGTYGVVYKAQN--SDGESFALKKIRLEKEDEGIPSTAIREISILKELR-H 59 Query: 936 PNVVTLVAHTILDMGRGREALLLM-EFCERSLVSALDARGTAGFYDDEQVALIFRDICNA 1112 N+V L D+ ++ L+L+ E ++ L +D G + + N Sbjct: 60 SNIVKLY-----DVIHAKKRLILVFEHLDQDLKKLIDV--CDGGLESVTAKSFLLQLLNG 112 Query: 1113 VFAMHCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKH 1292 + +C V HRDLK +N+L+ +G K+ DFG + F P R E + Sbjct: 113 I--AYCHEHRVLHRDLKPQNLLINREGELKIADFGLA----RAFGIPARRYTHEVV---- 162 Query: 1293 TTPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQILNGNYRIPEL 1472 T YRAP++ L + S +DIW++GC+ + + F G S+ L ++I Sbjct: 163 -TLWYRAPDI--LMGSKKYSTPIDIWSVGCIFAEMVNGRPLFPGASETDQLMRIFKILGT 219 Query: 1473 P 1475 P Sbjct: 220 P 220
>P00546:CDC28_YEAST Cell division control protein 28 - Saccharomyces cerevisiae (Baker's| yeast) Length = 298 Score = 70.1 bits (170), Expect = 5e-11 Identities = 82/324 (25%), Positives = 138/324 (42%), Gaps = 5/324 (1%) Frame = +3 Query: 777 EAIAEGGFSCVYLARDLT--NPAKHYALKHVIVQDKES--LDLVHKEITVMRALKGHPNV 944 E + EG + VY A DL + ALK + ++ ++ +EI++++ LK N+ Sbjct: 12 EKVGEGTYGVVYKALDLRPGQGQRVVALKKIRLESEDEGVPSTAIREISLLKELKDD-NI 70 Query: 945 VTLVAHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAM 1124 V L D + L+ EF + L ++ + V +C + Sbjct: 71 VRLYDIVHSD---AHKLYLVFEFLDLDLKRYMEGIPKDQPLGADIVKKFMMQLCKGI--A 125 Query: 1125 HCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHTTPA 1304 +C + + HRDLK +N+L+ DG KL DFG + F P R +I+ T Sbjct: 126 YCHSHRILHRDLKPQNLLINKDGNLKLGDFGLA----RAFGVP-LRAYTHEIV----TLW 176 Query: 1305 YRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQILNGNYRIPELPKYC 1484 YRAPE+ L + S VD W++GC+ +C K F G+S++ + +R+ P Sbjct: 177 YRAPEV--LLGGKQYSTGVDTWSIGCIFAEMCNRKPIFSGDSEIDQIFKIFRVLGTP--- 231 Query: 1485 SSITSLIEEMLQSSPDARPDITQVWFRVNELLPLELQKDLPDGSPSGSAFELQITEHEGL 1664 I + PD +P Q W R +L + +P P G ++ ++ Sbjct: 232 ---NEAIWPDIVYLPDFKPSFPQ-WRR------KDLSQVVPSLDPRGIDLLDKLLAYD-- 279 Query: 1665 ASSILPV*RIEATADPLH-HLQET 1733 P+ RI A +H + QE+ Sbjct: 280 -----PINRISARRAAIHPYFQES 298
>Q12152:YP150_YEAST Putative serine/threonine-protein kinase YPL150W - Saccharomyces| cerevisiae (Baker's yeast) Length = 901 Score = 69.7 bits (169), Expect = 7e-11 Identities = 86/292 (29%), Positives = 125/292 (42%), Gaps = 22/292 (7%) Frame = +3 Query: 747 DVGNVKVHVREAIAEGGFSCVYLARDLTNPAKHYALKHVIVQDKESLDLVHKEITVMRAL 926 +VGN K+ + I EG F VYLA L P H+++ + + Sbjct: 37 EVGNYKI--LKQIGEGSFGKVYLA--LHRPT-------------------HRKVCLKTSD 73 Query: 927 KGHPNVVTLVA-HTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDD----EQVALI 1091 K PN+V V H D + L + E + AL+ YD +++L+ Sbjct: 74 KNDPNIVREVFYHRQFDFPYITK-LYEVIVTESKVWMALEYCPGKELYDHLLSLRRISLL 132 Query: 1092 -----FRDICNAVF---AMHCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFD 1247 F I AV+ +MHC HRDLK EN+LL +G KL DFG +C Sbjct: 133 ECGELFAQISGAVYYAHSMHC-----VHRDLKLENILLDKNGNAKLTDFG---FTRECMT 184 Query: 1248 KPEERGIEEDIIRKHTTPAYRAPEMWDLYRREVISEKVDIWALGCLMYRIC--YLKSAFD 1421 K + T Y APE+ + RR K+DIW+LG ++Y + YL D Sbjct: 185 KTTLETV-------CGTTVYMAPEL--IERRTYDGFKIDIWSLGVILYTLITGYLPFDDD 235 Query: 1422 GESKL--QILNGNYRIPELPKYCSSI-----TSLIEEMLQSSPDARPDITQV 1556 E+K +I+N E PKY + + LI +L +P RP ++QV Sbjct: 236 DEAKTKWKIVN------EEPKYDAKVIPDDARDLISRLLAKNPGERPSLSQV 281
>O14047:PPK11_SCHPO Serine/threonine-protein kinase ppk11 - Schizosaccharomyces pombe| (Fission yeast) Length = 312 Score = 69.7 bits (169), Expect = 7e-11 Identities = 68/259 (26%), Positives = 117/259 (45%), Gaps = 5/259 (1%) Frame = +3 Query: 777 EAIAEGGFSCVYLARDLTNPAKHYALKHVIVQ-DKESLDLVHKEITVMRALKGHPNVVTL 953 + I +G F V+ A+D+ + +K ALK V + K+ ++ + +EI + L +T Sbjct: 10 QLIGQGSFGSVFRAQDVES-SKIVALKVVDLDATKDQIETLTQEINFLIDLNSVH--ITK 66 Query: 954 VAHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAMHCQ 1133 + +D G + ME+C+ S LD +G + + +A + R + A+ +H Q Sbjct: 67 YYASFVD---GFRLWITMEYCDGG--SCLDLLKLSGTFSERVIAEVMRQVLEALVYLHGQ 121 Query: 1134 TPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHTTPAYRA 1313 HRD+KA N+L DG KL DFG DK +D + TP + A Sbjct: 122 GK--MHRDIKAANILTMKDGLVKLADFGVSGQLESLRDK------NDDFV---GTPFWMA 170 Query: 1314 PEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDG--ESKLQILNGNYRIPEL--PKY 1481 PE + ++ + K DIW+LG Y + + + G K+ +L + P L K+ Sbjct: 171 PE---VVKQTGYNYKADIWSLGITAYELATGEPPYSGIHPMKVLLLIPKHSPPSLERSKF 227 Query: 1482 CSSITSLIEEMLQSSPDAR 1538 + + L+ +P R Sbjct: 228 SRAFCDFVSNCLKKNPKDR 246
>P53350:PLK1_HUMAN Serine/threonine-protein kinase PLK1 - Homo sapiens (Human)| Length = 603 Score = 69.7 bits (169), Expect = 7e-11 Identities = 61/194 (31%), Positives = 92/194 (47%), Gaps = 8/194 (4%) Frame = +3 Query: 999 LLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAMHCQTPPVAHRDLKAENVL 1178 +++E C R + L R A + + R I +H V HRDLK N+ Sbjct: 128 VVLELCRRRSLLELHKRRKA--LTEPEARYYLRQIVLGCQYLHRNR--VIHRDLKLGNLF 183 Query: 1179 LGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHT---TPAYRAPEMWDLYRREVI 1349 L D K+ DFG + +E D RK T TP Y APE+ ++ Sbjct: 184 LNEDLEVKIGDFGLATK------------VEYDGERKKTLCGTPNYIAPEVLS---KKGH 228 Query: 1350 SEKVDIWALGCLMYRICYLKSAFD----GESKLQILNGNYRIPELPKYCSSI-TSLIEEM 1514 S +VD+W++GC+MY + K F+ E+ L+I Y I PK+ + + SLI++M Sbjct: 229 SFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSI---PKHINPVAASLIQKM 285 Query: 1515 LQSSPDARPDITQV 1556 LQ+ P ARP I ++ Sbjct: 286 LQTDPTARPTINEL 299
>Q80Y86:MK15_MOUSE Mitogen-activated protein kinase 15 - Mus musculus (Mouse)| Length = 549 Score = 69.7 bits (169), Expect = 7e-11 Identities = 69/266 (25%), Positives = 121/266 (45%), Gaps = 8/266 (3%) Frame = +3 Query: 771 VREAIAEGGFSCVYLARDLTNPAKHYALKHVIVQDKESLDL--VHKEITVMRALKGHPNV 944 ++ + +G + V+ A D + A+K + ++ +D +EI +++ GHPN+ Sbjct: 16 IKRRLGKGAYGIVWKAMD-RRTGEVVAIKKIFDAFRDQIDAQRTFREIMLLKEFGGHPNI 74 Query: 945 VTLVAHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAM 1124 + L+ ++ R+ L+ E + L +A+ +G D IF + A + Sbjct: 75 IRLL--DVIPAKNDRDIYLVFESMDTDL-NAVIQKGR--LLKDIHKRCIFYQLLRATKFI 129 Query: 1125 HCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHTTPA 1304 H + V HRD K NVLL + KLCDFG + + P + + E + T Sbjct: 130 H--SGRVIHRDQKPANVLLDSACRVKLCDFGLARSLGDLPEGPGGQALTEYV----ATRW 183 Query: 1305 YRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGES---KLQILNGNYRIP--- 1466 YRAPE+ L + VD+W+LGC++ + + F G S +L+++ +P Sbjct: 184 YRAPEV--LLSSRWYTPGVDMWSLGCILGEMLRGQPLFPGTSTFHQLELILKTIPLPSME 241 Query: 1467 ELPKYCSSITSLIEEMLQSSPDARPD 1544 EL S ++LI + L S P D Sbjct: 242 ELQDLGSDYSALILQNLGSRPQQTLD 267
>P38147:CHK1_YEAST Serine/threonine-protein kinase CHK1 - Saccharomyces cerevisiae| (Baker's yeast) Length = 527 Score = 69.7 bits (169), Expect = 7e-11 Identities = 58/211 (27%), Positives = 101/211 (47%), Gaps = 6/211 (2%) Frame = +3 Query: 777 EAIAEGGFSCVYLARDLTNPAKHYALKHVIVQDKESLDLVHKEITVMRALKG----HPNV 944 + + +G F+CV A +P+ A+K + V + + L K+IT L+ HPNV Sbjct: 19 DTVGQGAFACVKNAHLQMDPSIILAVKFIHVPTCKKMGLSDKDITKEVVLQSKCSKHPNV 78 Query: 945 VTLVAHTILDMGRGREAL-LLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFA 1121 + L+ D +E + +++E + D D + F+ + +A+ Sbjct: 79 LRLI-----DCNVSKEYMWIILEMADGG--DLFDKIEPDVGVDSDVAQFYFQQLVSAINY 131 Query: 1122 MHCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHTTP 1301 +H + VAHRD+K EN+LL +G KL DFG S + + G + + +P Sbjct: 132 LHVECG-VAHRDIKPENILLDKNGNLKLADFGLASQFRR------KDGTLRVSMDQRGSP 184 Query: 1302 AYRAPEMWDLYRRE-VISEKVDIWALGCLMY 1391 Y APE+ LY E +++ DIW++G L++ Sbjct: 185 PYMAPEV--LYSEEGYYADRTDIWSIGILLF 213
>Q06850:CDPK1_ARATH Calcium-dependent protein kinase, isoform AK1 - Arabidopsis thaliana| (Mouse-ear cress) Length = 610 Score = 69.7 bits (169), Expect = 7e-11 Identities = 77/286 (26%), Positives = 124/286 (43%), Gaps = 19/286 (6%) Frame = +3 Query: 783 IAEGGFSCVYLARDLTNPAKHYALKHVIVQD---KESLDLVHKEITVMRALKGHPNVVTL 953 + +G F +L + T K +A K + + E ++ V +EI +M L GHPNV+++ Sbjct: 156 LGQGQFGTTFLCVEKTT-GKEFACKSIAKRKLLTDEDVEDVRREIQIMHHLAGHPNVISI 214 Query: 954 VAHTILDMGRGREAL---LLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAM 1124 G + + L+ME C D G Y + + A + R I V A Sbjct: 215 -------KGAYEDVVAVHLVMECCAGG--ELFDRIIQRGHYTERKAAELTRTIVGVVEA- 264 Query: 1125 HCQTPPVAHRDLKAENVLLGA---DGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHT 1295 C + V HRDLK EN L + D K DFG F KP++ + D++ Sbjct: 265 -CHSLGVMHRDLKPENFLFVSKHEDSLLKTIDFGL-----SMFFKPDD--VFTDVV---G 313 Query: 1296 TPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKL----QILNG--NY 1457 +P Y APE+ R+ + D+W+ G ++Y + F E++ Q+L+G ++ Sbjct: 314 SPYYVAPEV----LRKRYGPEADVWSAGVIVYILLSGVPPFWAETEQGIFEQVLHGDLDF 369 Query: 1458 RIPELPKYCSSITSLIEEMLQSSPDARPDITQV----WFRVNELLP 1583 P S L+ +ML P R QV W +V+ + P Sbjct: 370 SSDPWPSISESAKDLVRKMLVRDPKKRLTAHQVLCHPWVQVDGVAP 415
>Q5XIT0:CDKL2_RAT Cyclin-dependent kinase-like 2 - Rattus norvegicus (Rat)| Length = 507 Score = 69.7 bits (169), Expect = 7e-11 Identities = 83/326 (25%), Positives = 137/326 (42%), Gaps = 48/326 (14%) Frame = +3 Query: 783 IAEGGFSCVYLARDLTNPAKHYALKHVIVQDKESL--DLVHKEITVMRALKGHPNVVTLV 956 + EG + V R+ + + A+K + D + + + +EI +++ L+ H N+V L+ Sbjct: 10 VGEGSYGMVMKCRN-KDSGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLR-HENLVNLL 67 Query: 957 AHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAMHCQT 1136 + + L+ EF + +++ D + D + V I N + C + Sbjct: 68 EVC----KKKKRWYLVFEFVDHTILD--DLKLFPNGLDYQVVQKYLFQIINGIG--FCHS 119 Query: 1137 PPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHTTPAYRAP 1316 + HRD+K EN+L+ G KLCDFG T P E + D + T YRAP Sbjct: 120 HNIIHRDIKPENILVSQSGVVKLCDFGFART----LAAPGE--VYTDYV---ATRWYRAP 170 Query: 1317 EMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQILN------GN-------- 1454 E+ L + VDIWA+GCL+ + + F GES + L+ GN Sbjct: 171 EL--LVGDVKYGKAVDIWAIGCLVIEMLMGQPLFPGESDIDQLHHIMTCLGNLIPRHQEL 228 Query: 1455 ---------YRIPEL------------PKYCSSITSLIEEMLQSSPDARP---DITQVWF 1562 R+PE+ PK + SL ++ L PD RP D+ F Sbjct: 229 FYKNPVFAGVRLPEIKDIEAEPLESRYPKLPEVVISLAKKCLHIDPDKRPLCADLLHHDF 288 Query: 1563 --------RVNELLPLELQKDLPDGS 1616 R ++ L L+++KD + S Sbjct: 289 FQMDGFAERFSQELQLKIEKDARNNS 314
>Q9DGA2:CDC2_ORYJA Cell division control protein 2 homolog - Oryzias javanicus (Javanese| ricefish) Length = 303 Score = 69.7 bits (169), Expect = 7e-11 Identities = 71/263 (26%), Positives = 112/263 (42%), Gaps = 14/263 (5%) Frame = +3 Query: 777 EAIAEGGFSCVYLARDLTNPAKHYALKHVIVQDKES--LDLVHKEITVMRALKGHPNVVT 950 E I EG + VY R + + A+K + ++ +E +E+++++ LK HPNVV Sbjct: 8 EKIGEGTYGVVYKGRHKST-GQVVAMKKIRLESEEEGVPSTAVREVSLLQELK-HPNVVR 65 Query: 951 LVAHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAMHC 1130 L+ ++ R L+ EF L LD+ + + D V I ++ C Sbjct: 66 LL-DVLMQESR---LYLIFEFLSMDLKKYLDSIPSGQYMDPMLVKSYLYQILEGIY--FC 119 Query: 1131 QTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHTTPAYR 1310 V HRDLK +N+L+ G KL DFG + F P E + T YR Sbjct: 120 HRRRVLHRDLKPQNLLIDNKGVIKLADFGLA----RAFGVPVRVYTHEVV-----TLWYR 170 Query: 1311 APEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQILNGNYR---------- 1460 APE+ L S VD+W+ G + + K F G+S++ L +R Sbjct: 171 APEV--LLGSPRYSTPVDVWSTGTIFAELATKKPLFHGDSEIDQLFRIFRTLGTPNNDVW 228 Query: 1461 --IPELPKYCSSITSLIEEMLQS 1523 + LP Y ++ +E L S Sbjct: 229 PDVESLPDYKNTFPKWMEGSLSS 251
>Q7T6X2:YR826_MIMIV Putative serine/threonine-protein kinase/receptor R826 precursor -| Mimivirus Length = 1657 Score = 69.3 bits (168), Expect = 9e-11 Identities = 71/285 (24%), Positives = 127/285 (44%), Gaps = 6/285 (2%) Frame = +3 Query: 720 SGGLEGRTIDVGNVKVHVREAIAEGGFSCVYLARDLTNPAKHYALKHVIVQ--DKESLDL 893 S GL I+ +K+ E I G + VY + A+K I Q D+ L Sbjct: 1386 SAGLCSWVINYDEIKMG--EQIGLGSYGVVYRGKWKNVDV---AIKKFIKQKIDENHLLG 1440 Query: 894 VHKEITVMRALKGHPNVVTLVAHTILDMGRGREALLLMEFCERSLVSALDARGTAG-FYD 1070 + +EI ++ L HPN++T+V ++ + ++ E+ + + DA T + Sbjct: 1441 IREEIAFLKKLH-HPNIITMVGASL----KKPNICIVTEYMAKG--NLRDAMRTCTPKLE 1493 Query: 1071 DEQVALIFRDICNAVFAMHCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDK 1250 Q I +I + +H PP+ HRD+K N+L+ + K+ DFG F + Sbjct: 1494 WHQKIKILVNIAKGISYLHSFDPPIIHRDIKPSNILIDENWNVKIADFG--------FAR 1545 Query: 1251 PEERGIEEDIIRKHTTPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGES 1430 +E E I+ + TP + APE + R ++ EKVD+++ G +M+ + K F G + Sbjct: 1546 IKE---ENAIMTRCGTPCWTAPE---IIRNDIYDEKVDVFSFGIVMWEVLTCKEPFIGAN 1599 Query: 1431 KLQILNGNYR--IPELPKYC-SSITSLIEEMLQSSPDARPDITQV 1556 ++I P++P+ C L+ + + RP + V Sbjct: 1600 FMKITMDILEDVRPKIPQDCPEEFAKLMRKCWHAKSTKRPTMDDV 1644 Score = 42.7 bits (99), Expect = 0.009 Identities = 61/254 (24%), Positives = 104/254 (40%), Gaps = 9/254 (3%) Frame = +3 Query: 903 EITVMRALKGHPNVVTLVAHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQV 1082 E+ VM L+ HPNVV +A + + + ++MEF + +L D Sbjct: 832 EVRVMTTLR-HPNVVLFMAAST----KPPKMCIVMEFMA---LGSLHDLLKNELIPDIPF 883 Query: 1083 ALIFRDICNAVFAMH-CQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEE 1259 AL + A MH + + HRDLK+ N+LL K+ DFG K + Sbjct: 884 ALKVKIAYQASKGMHFLHSSGITHRDLKSLNLLLDIKWNVKVSDFGLTKF------KSDV 937 Query: 1260 RGIEEDIIRKHTTPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGES--- 1430 + I + + T + APE+ REV D+++ G +M+ + + G S Sbjct: 938 KSINPE--KFAGTIQWTAPEILS-EDREVDYILSDVYSFGIIMWELITRDQPYFGMSPAA 994 Query: 1431 -KLQILNGNYRIPELPKYCSSITSLIEEMLQS----SPDARPDITQVWFRVNELLPLELQ 1595 + ++ NYR + S + E+L S P RP ++ R++ L+ Sbjct: 995 IAVSVIRDNYRPVISDQLRSEVAPEYIELLTSCWHFDPTIRPTFLEIMTRLSNLMGDSGM 1054 Query: 1596 KDLPDGSPSGSAFE 1637 + S + S F+ Sbjct: 1055 TGMSSSSSNSSKFD 1068
>Q8WNU8:NEK11_MACFA Serine/threonine-protein kinase Nek11 - Macaca fascicularis (Crab| eating macaque) (Cynomolgus monkey) Length = 637 Score = 69.3 bits (168), Expect = 9e-11 Identities = 74/276 (26%), Positives = 119/276 (43%), Gaps = 14/276 (5%) Frame = +3 Query: 771 VREAIAEGGFSCVYLARDLTNPAKH----YALKHVIVQDKESLDLVHKEITVMRALK-GH 935 +++ + G F VYL D AK LK + V + + V + K H Sbjct: 31 LQQKLGSGSFGTVYLVSD--KKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKLDH 88 Query: 936 PNVVTLVAHTILDMGRGREALLLMEFCE-RSLVSALDARGTAG-FYDDEQVALIFRDICN 1109 P +V A + ++ E+CE R L + AG + D Q+ F + Sbjct: 89 PAIVKFHASFV----EQDNFCIITEYCEGRDLDYKIQEYKEAGKIFPDNQIIEWFIQLLL 144 Query: 1110 AVFAMHCQTPPVAHRDLKAENVLLGADGAWKLCDFG-SVSTNHKCFDKPEERGIEEDIIR 1286 V MH + + HRDLK++N+ L + K+ DFG S C D+ Sbjct: 145 GVDYMHERR--ILHRDLKSKNIFL-KNNLLKIGDFGVSRLLMGSC-----------DLAT 190 Query: 1287 KHT-TPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGES----KLQILNG 1451 T TP Y +PE + + K DIW+L C++Y +C + AF G + L+I+ G Sbjct: 191 TLTGTPHYMSPEA---LKHQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEG 247 Query: 1452 NYRIPELP-KYCSSITSLIEEMLQSSPDARPDITQV 1556 + P LP +Y + +++E ML +P RP ++ Sbjct: 248 D--TPSLPERYPKELNTIMESMLNKNPSLRPSAIEI 281
>Q924I2:M4K3_RAT Mitogen-activated protein kinase kinase kinase kinase 3 - Rattus| norvegicus (Rat) Length = 873 Score = 69.3 bits (168), Expect = 9e-11 Identities = 68/265 (25%), Positives = 119/265 (44%), Gaps = 10/265 (3%) Frame = +3 Query: 777 EAIAEGGFSCVYLARDLTNPAKHYALKHVIVQDKESLDLVHKEITVMRALKGHPNVVTLV 956 + I G + VY AR++ N + A+K + ++ E +V +EI +M+ K H N+V Sbjct: 20 QRIGSGTYGDVYKARNV-NTGELAAIKVIKLEPGEDFAVVQQEIIMMKDCK-HANIVAYF 77 Query: 957 AHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAMHCQT 1136 + R + + MEFC S D G + Q+A + R+ ++ +H + Sbjct: 78 GSYL----RRDKLWICMEFCGGG--SLQDIYHVTGPLSELQIAYVSRETLQGLYYLHSKG 131 Query: 1137 PPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHT---TPAY 1307 HRD+K N+LL +G KL DFG VS I I ++ + TP + Sbjct: 132 K--MHRDIKGANILLTDNGHVKLADFG-VSAQ-----------ITATIAKRKSFIGTPYW 177 Query: 1308 RAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQIL----NGNYRIPELP 1475 APE+ + R+ ++ D+WA+G + L+ ++ L N++ P+L Sbjct: 178 MAPEVAAVERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLK 237 Query: 1476 ---KYCSSITSLIEEMLQSSPDARP 1541 K+ +S ++ L +P RP Sbjct: 238 DKLKWSNSFHHFVKMALTKNPKKRP 262
>Q61161:M4K2_MOUSE Mitogen-activated protein kinase kinase kinase kinase 2 - Mus| musculus (Mouse) Length = 821 Score = 69.3 bits (168), Expect = 9e-11 Identities = 56/204 (27%), Positives = 94/204 (46%), Gaps = 3/204 (1%) Frame = +3 Query: 777 EAIAEGGFSCVYLARDLTNPAKHYALKHVIVQDKESLDLVHKEITVMRALKGHPNVVTLV 956 + + G + VY ARD T ++ A+K V + + + + +EIT++R + HPNVV + Sbjct: 20 QRVGAGTYGDVYKARD-TVTSELAAVKIVKLDPGDDISSLQQEITILRECR-HPNVVAYI 77 Query: 957 AHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAMHCQT 1136 + R + MEFC S + G ++ Q+A + R+ + +H Q Sbjct: 78 GSYL----RNDRLWICMEFCGGG--SLQEIYHATGPLEERQIAYVCREALKGLHHLHSQG 131 Query: 1137 PPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHT---TPAY 1307 HRD+K N+LL G KL DFG + + ++ + TP + Sbjct: 132 K--IHRDIKGANLLLTLQGDVKLADFGVSGE------------LTASVAKRRSFIGTPYW 177 Query: 1308 RAPEMWDLYRREVISEKVDIWALG 1379 APE+ + R+ +E D+WALG Sbjct: 178 MAPEVAAVERKGGYNELCDVWALG 201
>Q8N568:DCLK2_HUMAN Serine/threonine-protein kinase DCLK2 - Homo sapiens (Human)| Length = 766 Score = 69.3 bits (168), Expect = 9e-11 Identities = 78/284 (27%), Positives = 126/284 (44%), Gaps = 19/284 (6%) Frame = +3 Query: 762 KVHVREAIAEGGFSCVYLARDLTNPAKHYALKHVIVQDKESL----DLVHKEITVMRALK 929 K + + I +G F+ V D + K +ALK + DK L+ E++++R +K Sbjct: 393 KYKIGKVIGDGNFAVVKECIDRST-GKEFALKII---DKAKCCGKEHLIENEVSILRRVK 448 Query: 930 GHPNVVTLVAHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICN 1109 HPN++ LV +M E L+ME + DA ++ Y + + + ++ N Sbjct: 449 -HPNIIMLVE----EMETATELFLVMELVKGG--DLFDAITSSTKYTERDGSAMVYNLAN 501 Query: 1110 AVFAMHCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRK 1289 A+ +H + + HRD+K EN+L+ C++ + + K D +E + Sbjct: 502 ALRYLHGLS--IVHRDIKPENLLV--------CEYPDGTKSLKLGDFGLATVVEGPLYTV 551 Query: 1290 HTTPAYRAPEMWDLYRREVISE-----KVDIWALGCLMYRICYLKSAFDGESKL------ 1436 TP Y APE +I+E KVDIWA G + Y + F E+ L Sbjct: 552 CGTPTYVAPE--------IIAETGYGLKVDIWAAGVITYILLCGFPPFRSENNLQEDLFD 603 Query: 1437 QILNGNYRIPELPKYCSSIT----SLIEEMLQSSPDARPDITQV 1556 QIL G P Y +IT LI +MLQ + +AR Q+ Sbjct: 604 QILAGKLEFP--APYWDNITDSAKELISQMLQVNVEARCTAGQI 645
>Q6NW76:AURKB_DANRE Serine/threonine-protein kinase 12 - Danio rerio (Zebrafish)| (Brachydanio rerio) Length = 320 Score = 69.3 bits (168), Expect = 9e-11 Identities = 83/314 (26%), Positives = 133/314 (42%), Gaps = 20/314 (6%) Frame = +3 Query: 690 QLMPKEH--SGPSGGLEGRTIDVGNVKV------HVREAIAEGGFSCVYLARDLTNPAKH 845 ++ P H SGP GR N KV + + +G F VYLAR+ Sbjct: 25 EMNPDTHAVSGP-----GRVPVKSNSKVLSIDDFDIGRPLGKGKFGNVYLARERKLKVV- 78 Query: 846 YALKHVIVQD--KESLD-LVHKEITVMRALKGHPNVVTLVAHTILDMGRGREALLLMEFC 1016 ALK + KE ++ + +EI + L+ HPN++ + D L++E+ Sbjct: 79 IALKVLFKSQMVKEGVEHQLRREIEIQSHLR-HPNILRFYNYFHDDT----RVFLILEYA 133 Query: 1017 ERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAMHCQTPPVAHRDLKAENVLLGADGA 1196 R + R G +DD++ A ++ +A+ +C V HRD+K EN+LLG G Sbjct: 134 PRGEMYKELQR--YGRFDDQRTATYMEEVSDAL--QYCHEKKVIHRDIKPENLLLGYRGE 189 Query: 1197 WKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHT---TPAYRAPEMWDLYRREVISEKVDI 1367 K+ DFG + +R+ T T Y PEM + + + EKVD+ Sbjct: 190 LKIADFG--------------WSVHAPSLRRRTMCGTLDYLPPEMIEGHSHD---EKVDL 232 Query: 1368 WALGCLMYRICYLKSAFDGESKLQILNGNYRIP-ELPKYCS-SITSLIEEMLQSSPDARP 1541 W++G L Y F+ S + ++ + PK S LI ++L+ SP R Sbjct: 233 WSIGVLCYECLVGNPPFETASHAETYKRITKVDLQFPKLVSEGARDLISKLLRHSPSMRL 292 Query: 1542 DITQV----WFRVN 1571 + V W + N Sbjct: 293 PLRSVMEHPWVKAN 306
>Q8C1R0:TSSK5_MOUSE Testis-specific serine/threonine-protein kinase 5 - Mus musculus| (Mouse) Length = 372 Score = 68.9 bits (167), Expect = 1e-10 Identities = 76/283 (26%), Positives = 116/283 (40%), Gaps = 25/283 (8%) Frame = +3 Query: 783 IAEGGFSCVYLARDLTNPAKHY--------ALKHVIVQDK----------ESLDLVHKEI 908 I G FS VYLA KH +H +V K S + +EI Sbjct: 33 IGSGAFSKVYLAYATRERMKHNPRLSSDLRGKRHTMVAIKIVSMAEAPAEYSRKFLPREI 92 Query: 909 TVMRALKGHPNVVTLVAHTILDMGRGREALLLMEFCERS-----LVSALDARGTAGFYDD 1073 + A H N+V L + + L++E R + + D R G ++ Sbjct: 93 LSLNATYKHMNIVQLYE----TYQNSQRSYLVLELAARGDLLEHINAVSDLRCCPGL-EE 147 Query: 1074 EQVALIFRDICNAVFAMHCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKP 1253 E+ +F + +AV HC + HRDLK EN+LL G KL DFG + Sbjct: 148 EEARRLFWQLVSAV--AHCHNVGIVHRDLKCENILLDDQGFIKLTDFGFANW-------- 197 Query: 1254 EERGIEEDIIRKHT-TPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGES 1430 G++ ++ + AY APE+ L ++ E+ D+W+LG +++ + K F Sbjct: 198 --VGLKNSLLSTFCGSVAYTAPEI--LMSKKYNGEQADLWSLGIILHAMVSGKLPFKEHQ 253 Query: 1431 KLQILNGNYRIPEL-PKYCSSITSLIEEMLQSSPDARPDITQV 1556 ++LN R P P LI +LQ P R D+ QV Sbjct: 254 PHRMLNLIRRGPIFRPGLSPECRDLIRGLLQLHPCERLDLQQV 296
>Q75DK7:STE20_ASHGO Serine/threonine-protein kinase STE20 - Ashbya gossypii (Yeast)| (Eremothecium gossypii) Length = 971 Score = 68.9 bits (167), Expect = 1e-10 Identities = 65/258 (25%), Positives = 118/258 (45%), Gaps = 8/258 (3%) Frame = +3 Query: 783 IAEGGFSCVYLARDLTNPAKHYALKHVIVQDKESLDLVHKEITVMRALKGHPNVVTLVAH 962 I +G VY A ++ A A+K + ++ + +L+ EI VM+ + H N+V + Sbjct: 689 IGQGASGGVYTAYEIGTNAS-VAIKQMNLEKQPKKELIINEILVMKGSR-HNNIVNFIDS 746 Query: 963 TILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAMHCQTPP 1142 +L + ++ME+ E ++ + T + Q+A + R+ + +H + Sbjct: 747 YLLK----GDLWVIMEYMEGGSLTDVV---THCILTEGQIAAVSRETLRGLHFLHSKG-- 797 Query: 1143 VAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHT---TPAYRA 1313 V HRD+K++N+LL DG KL DFG + I E +++ T TP + A Sbjct: 798 VIHRDIKSDNILLSMDGNIKLTDFGFCAQ------------INETNLKRTTMVGTPYWMA 845 Query: 1314 PEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQIL-----NGNYRIPELPK 1478 PE + R+ KVDIW+LG ++ + + + E+ L+ L NG ++ + Sbjct: 846 PE---VVSRKEYGPKVDIWSLGIMIIEMIEGEPPYLNETPLRALYLIATNGTPKLKDADS 902 Query: 1479 YCSSITSLIEEMLQSSPD 1532 + LQS P+ Sbjct: 903 LSPVFKRFLSWGLQSQPE 920
>O35942:NEK2_MOUSE Serine/threonine-protein kinase Nek2 - Mus musculus (Mouse)| Length = 443 Score = 68.9 bits (167), Expect = 1e-10 Identities = 68/230 (29%), Positives = 102/230 (44%), Gaps = 12/230 (5%) Frame = +3 Query: 903 EITVMRALKGHPNVVTLVAHTILDMGRGREAL-LLMEFCERSLVSALDARGTAG--FYDD 1073 E+ ++R LK HPN+V I R L ++ME+CE ++++ ++GT + ++ Sbjct: 55 EVNLLRELK-HPNIVRYYDRII---DRTNTTLYIVMEYCEGGDLASVISKGTKDRQYLEE 110 Query: 1074 EQVALIFRDICNAVFAMHCQTP---PVAHRDLKAENVLLGADGAWKLCDFGSVST-NHKC 1241 E V + + A+ H ++ V HRDLK NV L + KL DFG NH Sbjct: 111 EFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDSKHNVKLGDFGLARILNHDT 170 Query: 1242 FDKPEERGIEEDIIRKHTTPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFD 1421 G TP Y +PE +EK DIW+L CL+Y +C L F Sbjct: 171 SFAKTFVG----------TPYYMSPEQMSCLS---YNEKSDIWSLACLLYELCALMPPFT 217 Query: 1422 G----ESKLQILNGNY-RIPELPKYCSSITSLIEEMLQSSPDARPDITQV 1556 E +I G + RIP +Y + LI ML RP + ++ Sbjct: 218 AFNQKELAGKIREGRFRRIPY--RYSDGLNDLITRMLFLKDYHRPSVEEI 265
>Q8NG66:NEK11_HUMAN Serine/threonine-protein kinase Nek11 - Homo sapiens (Human)| Length = 645 Score = 68.9 bits (167), Expect = 1e-10 Identities = 74/276 (26%), Positives = 119/276 (43%), Gaps = 14/276 (5%) Frame = +3 Query: 771 VREAIAEGGFSCVYLARDLTNPAKH----YALKHVIVQDKESLDLVHKEITVMRALK-GH 935 +++ + G F VYL D AK LK + V + + V + K H Sbjct: 31 LQQKLGSGSFGTVYLVSD--KKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKLDH 88 Query: 936 PNVVTLVAHTILDMGRGREALLLMEFCE-RSLVSALDARGTAG-FYDDEQVALIFRDICN 1109 P +V A + ++ E+CE R L + AG + + Q+ F + Sbjct: 89 PAIVKFHASFV----EQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLL 144 Query: 1110 AVFAMHCQTPPVAHRDLKAENVLLGADGAWKLCDFG-SVSTNHKCFDKPEERGIEEDIIR 1286 V MH + + HRDLK++NV L + K+ DFG S C D+ Sbjct: 145 GVDYMHERR--ILHRDLKSKNVFL-KNNLLKIGDFGVSRLLMGSC-----------DLAT 190 Query: 1287 KHT-TPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGES----KLQILNG 1451 T TP Y +PE + + K DIW+L C++Y +C + AF G + L+I+ G Sbjct: 191 TLTGTPHYMSPEA---LKHQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEG 247 Query: 1452 NYRIPELP-KYCSSITSLIEEMLQSSPDARPDITQV 1556 + P LP +Y + +++E ML +P RP ++ Sbjct: 248 D--TPSLPERYPKELNAIMESMLNKNPSLRPSAIEI 281
>Q501V0:KPSH1_DANRE Serine/threonine-protein kinase H1 homolog - Danio rerio (Zebrafish)| (Brachydanio rerio) Length = 422 Score = 68.9 bits (167), Expect = 1e-10 Identities = 68/270 (25%), Positives = 115/270 (42%), Gaps = 11/270 (4%) Frame = +3 Query: 762 KVHVREAIAEGGFSCVYLARDLTNPAKHYALKHVIVQDKESLDLVHKEITVMRALKGHPN 941 K ++ I G FS V + + YA+K + + +E ++ E+ V+R ++ H N Sbjct: 95 KYDIKALIGRGSFSRVVRVEHRST-RQPYAIKMIETRYREGREVCESELCVLRRVR-HTN 152 Query: 942 VVTLVAHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFA 1121 ++ L+ ++ME D T G + + + + + + V Sbjct: 153 IIQLMEV----FETAERVYMVMELATGG--ELFDRIITRGSFTERDATRVLQMVLDGVKY 206 Query: 1122 MHCQTPPVAHRDLKAENVLL---GADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKH 1292 +H T + HRDLK EN+L GAD + DFG ST K ++ + K Sbjct: 207 LH--TLGITHRDLKPENLLYYHPGADSKIMITDFGLASTRKK----------GDECLMKT 254 Query: 1293 T--TPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKL----QILNGN 1454 T TP Y APE + R+ + VD+WALG + Y + F+ ++++ QIL G Sbjct: 255 TCGTPEYIAPE---ILVRKPYTNAVDMWALGVISYILLSGTMPFEDDNRMRLYRQILKGK 311 Query: 1455 YRI--PELPKYCSSITSLIEEMLQSSPDAR 1538 Y P + I+ +L P+ R Sbjct: 312 YSFSGEPWPSVSNLAKDFIDRVLTVDPNER 341
>P34556:CDC2_CAEEL Cell division control protein 2 homolog - Caenorhabditis elegans| Length = 332 Score = 68.9 bits (167), Expect = 1e-10 Identities = 73/254 (28%), Positives = 114/254 (44%), Gaps = 2/254 (0%) Frame = +3 Query: 777 EAIAEGGFSCVYLARDLTNPAKHYALKHVIVQDKES--LDLVHKEITVMRALKGHPNVVT 950 E I EG + VY ++ A A+K + ++ ++ +EI++++ L+ HPNVV Sbjct: 26 EKIGEGTYGVVYKGKNRRTNAM-VAMKKIRLESEDEGVPSTAVREISLLKELQ-HPNVVG 83 Query: 951 LVAHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAMHC 1130 L A I+ R L+ EF L +D G + E + I A+ C Sbjct: 84 LEA-VIMQENR---LFLIFEFLSFDLKRYMDQLGKDEYLPLETLKSYTFQILQAM--CFC 137 Query: 1131 QTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHTTPAYR 1310 V HRDLK +N+L+ +GA KL DFG + P E + T YR Sbjct: 138 HQRRVIHRDLKPQNLLVDNNGAIKLADFGLA----RAIGIPIRVYTHEVV-----TLWYR 188 Query: 1311 APEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQILNGNYRIPELPKYCSS 1490 APE+ L + S VD+W++GC+ + K F G+S++ L +R+ P Sbjct: 189 APEI--LMGAQRYSMGVDMWSIGCIFAEMATKKPLFQGDSEIDELFRIFRVLGTP----- 241 Query: 1491 ITSLIEEMLQSSPD 1532 T L ++S PD Sbjct: 242 -TELEWNGVESLPD 254
>Q7RM49:CDC2H_PLAYO Cell division control protein 2 homolog - Plasmodium yoelii yoelii| Length = 289 Score = 68.9 bits (167), Expect = 1e-10 Identities = 63/242 (26%), Positives = 113/242 (46%), Gaps = 4/242 (1%) Frame = +3 Query: 762 KVHVREAIAEGGFSCVYLARDLTNPAKHYALKHVIVQDKES---LDLVHKEITVMRALKG 932 K H E I EG + VY A++ + + +ALK + ++ ++ + +EI++++ L+ Sbjct: 3 KYHGLEKIGEGTYGVVYKAQN--SDGESFALKKIRLEKEDEGIPSTVSIREISILKELR- 59 Query: 933 HPNVVTLVAHTILDMGRGREALLLM-EFCERSLVSALDARGTAGFYDDEQVALIFRDICN 1109 H N+V L D+ ++ L+L+ E ++ L +D G + + N Sbjct: 60 HSNIVKLY-----DVIHAKKRLILVFEHLDQDLKKLIDV--CDGGLESVTAKSFLLQLLN 112 Query: 1110 AVFAMHCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRK 1289 + +C V HRDLK +N+L+ +G K+ DFG + F P R E + Sbjct: 113 GI--AYCHEHRVLHRDLKPQNLLINREGELKIADFGLA----RAFGIPARRYTHEVV--- 163 Query: 1290 HTTPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQILNGNYRIPE 1469 T YRAP++ L + S +DIW++GC+ + + F G S+ L ++I Sbjct: 164 --TLWYRAPDI--LMGSKKYSTPIDIWSVGCIFAEMVNGRPLFPGVSETDQLMRIFKILG 219 Query: 1470 LP 1475 P Sbjct: 220 TP 221
>Q4Y4B1:CDC2H_PLACH Cell division control protein 2 homolog - Plasmodium chabaudi| Length = 288 Score = 68.9 bits (167), Expect = 1e-10 Identities = 64/241 (26%), Positives = 111/241 (46%), Gaps = 3/241 (1%) Frame = +3 Query: 762 KVHVREAIAEGGFSCVYLARDLTNPAKHYALKHVIVQ--DKESLDLVHKEITVMRALKGH 935 K H E I EG + VY A++ + + +ALK + ++ D+ +EI++++ L+ H Sbjct: 3 KYHGLEKIGEGTYGVVYKAQN--SDGESFALKKIRLEKEDEGIPSTAIREISILKELR-H 59 Query: 936 PNVVTLVAHTILDMGRGREALLLM-EFCERSLVSALDARGTAGFYDDEQVALIFRDICNA 1112 N+V L D+ ++ L+L+ E ++ L +D G + + N Sbjct: 60 SNIVKLY-----DVIHAKKRLILVFEHLDQDLKKLIDV--CDGGLESVTAKSFLLQLLNG 112 Query: 1113 VFAMHCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKH 1292 + +C V HRDLK +N+L+ +G K+ DFG + F P R E + Sbjct: 113 I--AYCHEHRVLHRDLKPQNLLINREGELKIADFGLA----RAFGIPARRYTHEVV---- 162 Query: 1293 TTPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQILNGNYRIPEL 1472 T YRAP++ L + S +DIW++GC+ + + F G S L ++I Sbjct: 163 -TLWYRAPDI--LMGSKKYSTPIDIWSVGCIFAEMVNGRPLFPGVSDTDQLMRIFKILGT 219 Query: 1473 P 1475 P Sbjct: 220 P 220
>P54666:CC2H3_TRYBB Cell division control protein 2 homolog 3 - Trypanosoma brucei brucei| Length = 311 Score = 68.9 bits (167), Expect = 1e-10 Identities = 67/244 (27%), Positives = 110/244 (45%), Gaps = 6/244 (2%) Frame = +3 Query: 723 GGLEGRTIDVGNVKVHVR----EAIAEGGFSCVYLARDLTNPAKHYALKHVIVQ--DKES 884 G L GR + G R + + EG + VY A D + ALK V + D+ Sbjct: 5 GALTGRQLSSGLKDQFDRYNRMDILGEGTYGVVYRAVDRAT-GQIVALKKVRLDRTDEGI 63 Query: 885 LDLVHKEITVMRALKGHPNVVTLVAHTILDMGRGREALLLMEFCERSLVSALDARGTAGF 1064 +E+++++ + HPN+V L+ D + L+ E+ + L AL+ RG A F Sbjct: 64 PQTALREVSILQEIH-HPNIVNLLDVICAD----GKLYLIFEYVDHDLKKALEKRGGA-F 117 Query: 1065 YDDEQVALIFRDICNAVFAMHCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCF 1244 +I++ + F C + HRDLK N+L+ D + K+ DFG + F Sbjct: 118 TGTTLKKIIYQLLEGLSF---CHRHRIVHRDLKPANILVTTDNSVKIADFGLA----RAF 170 Query: 1245 DKPEERGIEEDIIRKHTTPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDG 1424 P E + T YRAPE+ L + + VD+W++GC+ + K F G Sbjct: 171 QIPMHTYTHEVV-----TLWYRAPEI--LLGEKHYTPAVDMWSIGCIFAELARGKVLFRG 223 Query: 1425 ESKL 1436 +S++ Sbjct: 224 DSEI 227
>Q683C9:AUR2_ARATH Serine/threonine-protein kinase Aurora-2 - Arabidopsis thaliana| (Mouse-ear cress) Length = 282 Score = 68.9 bits (167), Expect = 1e-10 Identities = 71/262 (27%), Positives = 114/262 (43%), Gaps = 13/262 (4%) Frame = +3 Query: 771 VREAIAEGGFSCVYLARDLTNPAKHYALKHVI----VQDKESLDLVHKEITVMRALKGHP 938 + + + G F VYLAR+ + H V+ +Q + + +E+ + L+ HP Sbjct: 21 IGKPLGRGKFGHVYLARE--KRSDHIVALKVLFKAQLQQSQVEHQLRREVEIQSHLR-HP 77 Query: 939 NVVTLVAHTILDMGRGREALLLMEFCERS-LVSALDARGTAGFYDDEQVALIFRDICNAV 1115 N++ L + D R L++E+ R L L ++ + + A + A+ Sbjct: 78 NILRLYGY-FYDQKR---VYLILEYAVRGELYKELQK---CKYFSERRAATYVASLARAL 130 Query: 1116 FAMHCQTPPVAHRDLKAENVLLGADGAWKLCDFG-SVSTNHKCFDKPEERGIEEDIIRKH 1292 ++C V HRD+K EN+L+GA G K+ DFG SV T + R+ Sbjct: 131 --IYCHGKHVIHRDIKPENLLIGAQGELKIADFGWSVHTFN----------------RRR 172 Query: 1293 T---TPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFD----GESKLQILNG 1451 T T Y PEM + + VDIW+LG L Y Y F+ E+ +I+ Sbjct: 173 TMCGTLDYLPPEMVESVEHDA---SVDIWSLGILCYEFLYGVPPFEAREHSETYKRIVQV 229 Query: 1452 NYRIPELPKYCSSITSLIEEML 1517 + + P P SS LI +ML Sbjct: 230 DLKFPPKPIVSSSAKDLISQML 251
>P06782:SNF1_YEAST Carbon catabolite derepressing protein kinase - Saccharomyces| cerevisiae (Baker's yeast) Length = 633 Score = 68.6 bits (166), Expect = 2e-10 Identities = 80/300 (26%), Positives = 139/300 (46%), Gaps = 18/300 (6%) Frame = +3 Query: 750 VGNVKVHVREAIAEGGFSCVYLARDLTNPAKHYALKHV---IVQDKESLDLVHKEITVMR 920 +GN ++ + + EG F V LA T K ALK + ++ + + +EI+ +R Sbjct: 52 IGNYQIV--KTLGEGSFGKVKLAYHTTTGQK-VALKIINKKVLAKSDMQGRIEREISYLR 108 Query: 921 ALKGHPNVVTLVAHTILDMGRGR-EALLLMEFCERSLVSALDARGTAGFYDDEQVALIFR 1097 L+ HP+++ L D+ + + E ++++E+ L + R +++ F+ Sbjct: 109 LLR-HPHIIKLY-----DVIKSKDEIIMVIEYAGNELFDYIVQRDKMS---EQEARRFFQ 159 Query: 1098 DICNAVFAMHCQTPPVAHRDLKAENVLLGADGAWKLCDFG--SVSTNHKCFDKPEERGIE 1271 I +AV +C + HRDLK EN+LL K+ DFG ++ T+ Sbjct: 160 QIISAV--EYCHRHKIVHRDLKPENLLLDEHLNVKIADFGLSNIMTDGNF---------- 207 Query: 1272 EDIIRKHTTPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGES----KLQ 1439 + +P Y APE+ + + +VD+W+ G ++Y + + FD ES Sbjct: 208 --LKTSCGSPNYAAPEV--ISGKLYAGPEVDVWSCGVILYVMLCRRLPFDDESIPVLFKN 263 Query: 1440 ILNGNYRIPELPKYCS-SITSLIEEMLQSSPDARPDITQV----WFRVN---ELLPLELQ 1595 I NG Y LPK+ S LI+ ML +P R I ++ WF+V+ LLP +L+ Sbjct: 264 ISNGVY---TLPKFLSPGAAGLIKRMLIVNPLNRISIHEIMQDDWFKVDLPEYLLPPDLK 320
>P41808:SMK1_YEAST Sporulation-specific mitogen-activated protein kinase SMK1 -| Saccharomyces cerevisiae (Baker's yeast) Length = 388 Score = 68.6 bits (166), Expect = 2e-10 Identities = 54/204 (26%), Positives = 86/204 (42%), Gaps = 2/204 (0%) Frame = +3 Query: 831 NPAKHYALKHV--IVQDKESLDLVHKEITVMRALKGHPNVVTLVAHTILDMGRGREALLL 1004 +PA A+K + I + L +E+ M KGH N+V L+ I+ Sbjct: 61 SPAARIAVKKISNIFNKEILLKRAIRELKFMNFFKGHKNIVNLIDLEIVTSSPYDGLYCY 120 Query: 1005 MEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAMHCQTPPVAHRDLKAENVLLG 1184 E + L + + + + +++ +C + + V HRDLK N+L Sbjct: 121 QELIDYDLAKVIHSSVQLSEFHIKY--FLYQILCGLKYI---HSADVIHRDLKPGNILCT 175 Query: 1185 ADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHTTPAYRAPEMWDLYRREVISEKVD 1364 +G K+CDFG H F K ++ I T YRAPE+ L + S+ VD Sbjct: 176 LNGCLKICDFGLARGIHAGFFKCHST-VQPHITNYVATRWYRAPEL--LLSNQPYSKSVD 232 Query: 1365 IWALGCLMYRICYLKSAFDGESKL 1436 IWA+GC++ K F G + Sbjct: 233 IWAVGCILAEFYARKPVFMGRDSM 256
>Q10056:SHK2_SCHPO Serine/threonine-protein kinase shk2 - Schizosaccharomyces pombe| (Fission yeast) Length = 589 Score = 68.6 bits (166), Expect = 2e-10 Identities = 56/211 (26%), Positives = 103/211 (48%), Gaps = 4/211 (1%) Frame = +3 Query: 768 HVREAIAEGGFSCVYLARDLTNPA----KHYALKHVIVQDKESLDLVHKEITVMRALKGH 935 +V+ + +G VYLA+ + A+K + +Q + +L+ EITVMR H Sbjct: 310 NVKHKLGQGASGSVYLAKVVGGKQLGIFDSVAIKSIDLQCQTRKELILNEITVMRE-SIH 368 Query: 936 PNVVTLVAHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAV 1115 PN+VT + ++ R R ++ME+ ++ + + + Q+A I + C + Sbjct: 369 PNIVTYLDSFLV---RERHLWVVMEYMNAGSLTDIIEKSKL---TEAQIARICLETCKGI 422 Query: 1116 FAMHCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHT 1295 +H + + HRD+K++NVLL G K+ DFG + + ++ +R + Sbjct: 423 QHLHARN--IIHRDIKSDNVLLDNSGNIKITDFGFCA---RLSNRTNKR------VTMVG 471 Query: 1296 TPAYRAPEMWDLYRREVISEKVDIWALGCLM 1388 TP + APE + ++ KVDIW+LG ++ Sbjct: 472 TPYWMAPE---VVKQNEYGTKVDIWSLGIMI 499
>Q8C0Q4:NEK11_MOUSE Serine/threonine-protein kinase Nek11 - Mus musculus (Mouse)| Length = 628 Score = 68.6 bits (166), Expect = 2e-10 Identities = 67/269 (24%), Positives = 112/269 (41%), Gaps = 7/269 (2%) Frame = +3 Query: 771 VREAIAEGGFSCVYLARDL-TNPAKHY-ALKHVIVQDKESLDLVHKEITVMRALKGHPNV 944 +++ + G F VYL D P + LK + V + + V + + H Sbjct: 32 LQQKLGSGSFGTVYLVSDKKAKPGEELKVLKEISVGELNPNETVQANVEAQLLSRLHHPA 91 Query: 945 VTLVAHTILDMGRGREALLLMEFCE-RSLVSALDARGTAG-FYDDEQVALIFRDICNAVF 1118 + + ++ ++ E+CE R L + AG + + Q+ F + V Sbjct: 92 IVRFHASFMEQ---ETFCIITEYCEGRDLDYRIQEYKEAGKVFAENQIVEWFIQLLLGVD 148 Query: 1119 AMHCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHTT 1298 MH + + HRDLK++N+ L + K+ DFG G E T Sbjct: 149 YMHERR--ILHRDLKSKNIFL-KNNLLKIGDFGVSRLL---------MGSCELATTLTGT 196 Query: 1299 PAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQILNG--NYRIPEL 1472 P Y +PE + + K DIW+L C++Y +C L AF G S L ++ + P L Sbjct: 197 PHYMSPEA---LKHQGYDAKSDIWSLACILYEMCCLDHAFAGSSFLSVVLNIVEGKTPSL 253 Query: 1473 P-KYCSSITSLIEEMLQSSPDARPDITQV 1556 P +Y + +++E ML SP RP + Sbjct: 254 PDRYPRELNTIMERMLNKSPSLRPSAADI 282
>Q9UQ07:MOK_HUMAN MAPK/MAK/MRK overlapping kinase - Homo sapiens (Human)| Length = 419 Score = 68.6 bits (166), Expect = 2e-10 Identities = 64/220 (29%), Positives = 106/220 (48%), Gaps = 2/220 (0%) Frame = +3 Query: 783 IAEGGFSCVYLARDLTNPAKHYALKHVIVQDKESLDLVH--KEITVMRALKGHPNVVTLV 956 I EG FS V + L + +YA K + Q ES++ V+ +EI +R L HPN++ L Sbjct: 10 IGEGTFSEVMKMQSLRD-GNYYACKQM-KQRFESIEQVNNLREIQALRRLNPHPNILML- 66 Query: 957 AHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAMHCQT 1136 H ++ + L+ E + ++ + RG ++++ +C ++ +H Sbjct: 67 -HEVVFDRKSGSLALICELMDMNIYELI--RGRRYPLSEKKIMHYMYQLCKSLDHIHRNG 123 Query: 1137 PPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHTTPAYRAP 1316 + HRD+K EN+L+ D KL DFGS C ++ E I +T YRAP Sbjct: 124 --IFHRDVKPENILIKQD-VLKLGDFGS------CRSVYSKQPYTEYI----STRWYRAP 170 Query: 1317 EMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKL 1436 E L + K+D+W+ GC+ Y I L+ F G ++L Sbjct: 171 EC--LLTDGFYTYKMDLWSAGCVFYEIASLQPLFPGVNEL 208
>Q12851:M4K2_HUMAN Mitogen-activated protein kinase kinase kinase kinase 2 - Homo| sapiens (Human) Length = 819 Score = 68.6 bits (166), Expect = 2e-10 Identities = 56/204 (27%), Positives = 94/204 (46%), Gaps = 3/204 (1%) Frame = +3 Query: 777 EAIAEGGFSCVYLARDLTNPAKHYALKHVIVQDKESLDLVHKEITVMRALKGHPNVVTLV 956 + + G + VY ARD T ++ A+K V + + + + +EIT++R + HPNVV + Sbjct: 19 QRVGAGTYGDVYKARD-TVTSELAAVKIVKLDPGDDISSLQQEITILRECR-HPNVVAYI 76 Query: 957 AHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAMHCQT 1136 + R + MEFC S + G ++ Q+A + R+ + +H Q Sbjct: 77 GSYL----RNDRLWICMEFCGGG--SLQEIYHATGPLEERQIAYVCRERLKGLHHLHSQG 130 Query: 1137 PPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHT---TPAY 1307 HRD+K N+LL G KL DFG + + ++ + TP + Sbjct: 131 K--IHRDIKGANLLLTLQGDVKLADFGVSGE------------LTASVAKRRSFIGTPYW 176 Query: 1308 RAPEMWDLYRREVISEKVDIWALG 1379 APE+ + R+ +E D+WALG Sbjct: 177 MAPEVAAVERKGGYNELCDVWALG 200
>Q92772:CDKL2_HUMAN Cyclin-dependent kinase-like 2 - Homo sapiens (Human)| Length = 493 Score = 68.6 bits (166), Expect = 2e-10 Identities = 78/319 (24%), Positives = 133/319 (41%), Gaps = 46/319 (14%) Frame = +3 Query: 783 IAEGGFSCVYLARDLTNPAKHYALKHVIVQDKESL--DLVHKEITVMRALKGHPNVVTLV 956 + EG + V R+ + + A+K + D + + + +EI +++ L+ H N+V L+ Sbjct: 10 VGEGSYGMVMKCRN-KDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLR-HENLVNLL 67 Query: 957 AHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAMHCQT 1136 + + L+ EF + +++ L+ Y Q L I N + C + Sbjct: 68 EVC----KKKKRWYLVFEFVDHTILDDLELFPNGLDYQVVQKYLF--QIINGIG--FCHS 119 Query: 1137 PPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHTTPAYRAP 1316 + HRD+K EN+L+ G KLCDFG T P E + D + T YRAP Sbjct: 120 HNIIHRDIKPENILVSQSGVVKLCDFGFART----LAAPGE--VYTDYV---ATRWYRAP 170 Query: 1317 EMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKL------------------QI 1442 E+ L + VD+WA+GCL+ + + F G+S + ++ Sbjct: 171 EL--LVGDVKYGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQEL 228 Query: 1443 LNGN-----YRIPEL----------PKYCSSITSLIEEMLQSSPDARPDITQVWF----- 1562 N N R+PE+ PK + L ++ L PD RP ++ Sbjct: 229 FNKNPVFAGVRLPEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDFFQ 288 Query: 1563 ------RVNELLPLELQKD 1601 R ++ L L++QKD Sbjct: 289 MDGFAERFSQELQLKVQKD 307
>Q5RCH1:CDC2_PONPY Cell division control protein 2 homolog - Pongo pygmaeus (Orangutan)| Length = 297 Score = 68.6 bits (166), Expect = 2e-10 Identities = 63/225 (28%), Positives = 99/225 (44%), Gaps = 2/225 (0%) Frame = +3 Query: 777 EAIAEGGFSCVYLARDLTNPAKHYALKHVIVQDKES--LDLVHKEITVMRALKGHPNVVT 950 E I EG + VY R T + +K + ++ +E +EI++++ L+ HPN+V+ Sbjct: 8 EKIGEGTYGVVYKGRHKTT-GQVVTMKKIRLESEEEGVPSTAIREISLLKELR-HPNIVS 65 Query: 951 LVAHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAMHC 1130 L + D L+ EF L LD+ + D V I + + C Sbjct: 66 LQDVLMQDS----RLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGI--VFC 119 Query: 1131 QTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHTTPAYR 1310 + V HRDLK +N+L+ G KL DFG + F P E + T YR Sbjct: 120 HSRRVLHRDLKPQNLLIDDKGTIKLADFGLA----RAFGIPIRVYTHEVV-----TLWYR 170 Query: 1311 APEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQIL 1445 +PE+ L S VDIW++G + + K F G+S++ L Sbjct: 171 SPEV--LLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQL 213
>Q9DG98:CDC2_ORYLU Cell division control protein 2 homolog - Oryzias luzonensis (Luzon| ricefish) Length = 303 Score = 68.6 bits (166), Expect = 2e-10 Identities = 64/225 (28%), Positives = 100/225 (44%), Gaps = 2/225 (0%) Frame = +3 Query: 777 EAIAEGGFSCVYLARDLTNPAKHYALKHVIVQDKES--LDLVHKEITVMRALKGHPNVVT 950 E I EG + VY R + + A+K + ++ +E +E+++++ LK HPNVV Sbjct: 8 EKIGEGTYGVVYKGRHKST-GQVVAMKKIRLESEEEGVPSTAVREVSLLQELK-HPNVVR 65 Query: 951 LVAHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAMHC 1130 L+ ++ R L+ EF L LD+ + + D V I ++ C Sbjct: 66 LL-DVLMQESR---LYLIFEFLSMDLKKYLDSIPSGQYMDPMLVKSYLYQILEGIY--FC 119 Query: 1131 QTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHTTPAYR 1310 V HRDLK +N+L+ G KL DFG + F P E + T YR Sbjct: 120 HRRRVLHRDLKPQNLLIDNKGVIKLADFGLA----RAFGVPVRVYTHEVV-----TLWYR 170 Query: 1311 APEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQIL 1445 APE+ L S VD+W+ G + + K F G+S++ L Sbjct: 171 APEV--LLGSPRYSTPVDVWSTGTIFAELATKKPLFHGDSEIDQL 213
>Q9DGD3:CDC2_ORYLA Cell division control protein 2 homolog - Oryzias latipes (Medaka| fish) (Japanese ricefish) Length = 303 Score = 68.6 bits (166), Expect = 2e-10 Identities = 64/225 (28%), Positives = 100/225 (44%), Gaps = 2/225 (0%) Frame = +3 Query: 777 EAIAEGGFSCVYLARDLTNPAKHYALKHVIVQDKES--LDLVHKEITVMRALKGHPNVVT 950 E I EG + VY R + + A+K + ++ +E +E+++++ LK HPNVV Sbjct: 8 EKIGEGTYGVVYKGRHKST-GQVVAMKKIRLESEEEGVPSTAVREVSLLQELK-HPNVVR 65 Query: 951 LVAHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAMHC 1130 L+ ++ R L+ EF L LD+ + + D V I ++ C Sbjct: 66 LL-DVLMQESR---LYLIFEFLSMDLKKYLDSIPSGQYMDPMLVKSYLYQILEGIY--FC 119 Query: 1131 QTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHTTPAYR 1310 V HRDLK +N+L+ G KL DFG + F P E + T YR Sbjct: 120 HRRRVLHRDLKPQNLLIDNKGVIKLADFGLA----RAFGVPVRVYTHEVV-----TLWYR 170 Query: 1311 APEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQIL 1445 APE+ L S VD+W+ G + + K F G+S++ L Sbjct: 171 APEV--LLGSPRYSTPVDVWSTGTIFAELATKKPLFHGDSEIDQL 213
>Q75H77:SAPKA_ORYSJ Serine/threonine-protein kinase SAPK10 - Oryza sativa subsp. japonica| (Rice) Length = 362 Score = 68.2 bits (165), Expect = 2e-10 Identities = 76/299 (25%), Positives = 123/299 (41%), Gaps = 14/299 (4%) Frame = +3 Query: 783 IAEGGFSCVYLARDLTNPAKHYALKHVIVQDKESLDLVHKEITVMRALKGHPNVVTLVAH 962 I G F L R + + A+K++ DK + V +EI R+L+ HPN++ Sbjct: 29 IGSGNFGVARLMRSRAD-GQLVAVKYIERGDKID-ENVQREIINHRSLR-HPNIIRFKEV 85 Query: 963 TILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAMHCQTPP 1142 + ++ME+ + AG + +++ F+ + + V +C + Sbjct: 86 ILTPT----HLAIVMEYASGG--ELFERICNAGRFSEDEARFFFQQLISGV--SYCHSMQ 137 Query: 1143 VAHRDLKAENVLLGADGA--WKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHTTPAYRAP 1316 V HRDLK EN LL A K+CDFG S + +P+ TPAY AP Sbjct: 138 VCHRDLKLENTLLDGSTAPRLKICDFG-YSKSSVLHSQPKS---------TVGTPAYIAP 187 Query: 1317 EMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESK--------LQILNGNYRIPEL 1472 E+ L ++E + D+W+ G +Y + F+ + +IL Y IP+ Sbjct: 188 EV--LLKKEYDGKIADVWSCGVTLYVMLVGAYPFEDPDEPKNFRKTIQRILGVQYSIPDY 245 Query: 1473 PKYCSSITSLIEEMLQSSPDARPDITQV----WFRVNELLPLELQKDLPDGSPSGSAFE 1637 LI + ++P R I ++ WF N L DL D S S +E Sbjct: 246 VHISPECRDLIARIFVANPATRISIPEIRNHPWFLKN------LPADLMDDSKMSSQYE 298
>Q7Y0B9:SAPK8_ORYSJ Serine/threonine-protein kinase SAPK8 - Oryza sativa subsp. japonica| (Rice) Length = 371 Score = 68.2 bits (165), Expect = 2e-10 Identities = 75/287 (26%), Positives = 118/287 (41%), Gaps = 14/287 (4%) Frame = +3 Query: 783 IAEGGFSCVYLARDLTNPAKHYALKHVIVQDKESLDLVHKEITVMRALKGHPNVVTLVAH 962 I G F L RD + A+K++ +K D V +EI R+LK HPN++ Sbjct: 39 IGSGNFGVARLMRD-RRTMELVAVKYIERGEKID-DNVQREIINHRSLK-HPNIIRFKEV 95 Query: 963 TILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAMHCQTPP 1142 + ++ME+ + + + +++ F+ + + V +C + Sbjct: 96 ILTPT----HLAIVMEYASGGELFERICKNVR--FSEDEARYFFQQLISGV--SYCHSMQ 147 Query: 1143 VAHRDLKAENVLLGADGA--WKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHTTPAYRAP 1316 V HRDLK EN LL A K+CDFG S + +P+ TPAY AP Sbjct: 148 VCHRDLKLENTLLDGSPAPRLKICDFG-YSKSSVLHSQPKS---------TVGTPAYIAP 197 Query: 1317 EMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESK--------LQILNGNYRIPEL 1472 E+ L ++E + D+W+ G +Y + F+ + +ILN Y IPE Sbjct: 198 EV--LLKKEYDGKTADVWSCGVTLYVMVVGAYPFEDPEEPKNFRKTIQRILNVQYSIPEN 255 Query: 1473 PKYCSSITSLIEEMLQSSPDARPDITQV----WFRVNELLPLELQKD 1601 LI + P R I ++ WF N LP +L D Sbjct: 256 VDISPECRHLISRIFVGDPSLRITIPEIRSHGWFLKN--LPADLMDD 300
>Q7XKA8:SAPK5_ORYSJ Serine/threonine-protein kinase SAPK5 - Oryza sativa subsp. japonica| (Rice) Length = 370 Score = 68.2 bits (165), Expect = 2e-10 Identities = 74/291 (25%), Positives = 123/291 (42%), Gaps = 14/291 (4%) Frame = +3 Query: 771 VREAIAEGGFSCVYLARDLTNPAKHYALKHVIVQDKESLDLVHKEITVMRALKGHPNVVT 950 VRE I G F L R+ + I + + V +EI R+L+ HPN++ Sbjct: 7 VRE-IGAGNFGVAKLMRN--KETRELVAMKFIERGNRIDENVFREIVNHRSLR-HPNIIR 62 Query: 951 LVAHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAMHC 1130 + GR ++ME+ + AG + +++ F+ + V +C Sbjct: 63 FKEVVVT----GRHLAIVMEYAAGG--ELFERICEAGRFHEDEARYFFQQLVCGV--SYC 114 Query: 1131 QTPPVAHRDLKAENVLLGADGA--WKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHTTPA 1304 + HRDLK EN LL A K+CDFG S + +P+ TPA Sbjct: 115 HAMQICHRDLKLENTLLDGSPAPRLKICDFG-YSKSSLLHSRPKS---------TVGTPA 164 Query: 1305 YRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDG--------ESKLQILNGNYR 1460 Y APE+ L RRE + D+W+ G +Y + F+ ++ +I++ Y+ Sbjct: 165 YIAPEV--LSRREYDGKLADVWSCGVTLYVMLVGAYPFEDPKDPKNFRKTISRIMSVQYK 222 Query: 1461 IPELPKYCSSITSLIEEMLQSSPDARPDITQV----WFRVNELLPLELQKD 1601 IPE L+ + ++P R + ++ WF N LP EL+++ Sbjct: 223 IPEYVHVSQPCRHLLSRIFVANPYKRISMGEIKSHPWFLKN--LPRELKEE 271
>Q9R012:PLK2_RAT Serine/threonine-protein kinase PLK2 - Rattus norvegicus (Rat)| Length = 682 Score = 68.2 bits (165), Expect = 2e-10 Identities = 85/295 (28%), Positives = 125/295 (42%), Gaps = 12/295 (4%) Frame = +3 Query: 708 HSGPSGGLEGRTIDVGNVKVHVR-EAIAEGGFSCVYLARDLTNPAKHYALK---HVIVQD 875 HSGP + +D K + R + + +GGF+ Y DLTN K YA K H V Sbjct: 61 HSGPE--ISRIIVDPTTGKRYCRGKVLGKGGFAKCYEMTDLTNN-KVYAAKIIPHSRVAK 117 Query: 876 KESLDLVHKEITVMRALKGHPNVVTLVAHTILDMGRGREALLLMEFCER-SLVSALDARG 1052 + + KEI + R L H +VV H D +L+E+C R S+ L AR Sbjct: 118 PHQREKIDKEIELHRILH-HKHVVQFY-HYFEDK---ENIYILLEYCSRRSMAHILKARK 172 Query: 1053 TAGFYDDEQVALIFRDICNAVFAMHCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTN 1232 + +V R I + + +H Q + HRDLK N + K+ DFG + Sbjct: 173 VL---TEPEVRYYLRQIVSGLKYLHEQE--ILHRDLKLGNFFINEAMELKVGDFGLAARL 227 Query: 1233 HKCFDKPEERGIEEDIIRKHT---TPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICY 1403 +P E R+ T TP Y +PE+ + S DIWALGC+MY + Sbjct: 228 -----EPLEH-------RRRTICGTPNYLSPEVLNKQGHGCES---DIWALGCVMYTMLL 272 Query: 1404 LKSAFD----GESKLQILNGNYRIPELPKYCSSITSLIEEMLQSSPDARPDITQV 1556 + F+ E+ I Y +P + LI ML +P+ RP + + Sbjct: 273 GRPPFETTNLKETYRCIREARYTMPS--SLLAPAKHLIASMLSKNPEDRPSLDDI 325
>Q5R4L1:PLK2_PONPY Serine/threonine-protein kinase PLK2 - Pongo pygmaeus (Orangutan)| Length = 685 Score = 68.2 bits (165), Expect = 2e-10 Identities = 85/295 (28%), Positives = 125/295 (42%), Gaps = 12/295 (4%) Frame = +3 Query: 708 HSGPSGGLEGRTIDVGNVKVHVR-EAIAEGGFSCVYLARDLTNPAKHYALK---HVIVQD 875 HSGP + +D K + R + + +GGF+ Y DLTN K YA K H V Sbjct: 64 HSGPE--ISRIIVDPTTGKRYCRGKVLGKGGFAKCYEMTDLTNN-KVYAAKIIPHSRVAK 120 Query: 876 KESLDLVHKEITVMRALKGHPNVVTLVAHTILDMGRGREALLLMEFCER-SLVSALDARG 1052 + + KEI + R L H +VV H D +L+E+C R S+ L AR Sbjct: 121 PHQREKIDKEIELHRILH-HKHVVQFY-HYFEDK---ENIYILLEYCSRRSMAHILKARK 175 Query: 1053 TAGFYDDEQVALIFRDICNAVFAMHCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTN 1232 + +V R I + + +H Q + HRDLK N + K+ DFG + Sbjct: 176 VL---TEPEVRYYLRQIVSGLKYLHEQE--ILHRDLKLGNFFINEAMELKVGDFGLAARL 230 Query: 1233 HKCFDKPEERGIEEDIIRKHT---TPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICY 1403 +P E R+ T TP Y +PE+ + S DIWALGC+MY + Sbjct: 231 -----EPLEH-------RRRTICGTPNYLSPEVLNKQGHGCES---DIWALGCVMYTMLL 275 Query: 1404 LKSAFD----GESKLQILNGNYRIPELPKYCSSITSLIEEMLQSSPDARPDITQV 1556 + F+ E+ I Y +P + LI ML +P+ RP + + Sbjct: 276 GRPPFETTNLKETYRCIREARYTMPS--SLLAPAKHLIASMLSKNPEDRPSLDDI 328
>P53351:PLK2_MOUSE Serine/threonine-protein kinase PLK2 - Mus musculus (Mouse)| Length = 682 Score = 68.2 bits (165), Expect = 2e-10 Identities = 85/295 (28%), Positives = 125/295 (42%), Gaps = 12/295 (4%) Frame = +3 Query: 708 HSGPSGGLEGRTIDVGNVKVHVR-EAIAEGGFSCVYLARDLTNPAKHYALK---HVIVQD 875 HSGP + +D K + R + + +GGF+ Y DLTN K YA K H V Sbjct: 61 HSGPE--ISRIIVDPTTGKRYCRGKVLGKGGFAKCYEMTDLTNN-KVYAAKIIPHSRVAK 117 Query: 876 KESLDLVHKEITVMRALKGHPNVVTLVAHTILDMGRGREALLLMEFCER-SLVSALDARG 1052 + + KEI + R L H +VV H D +L+E+C R S+ L AR Sbjct: 118 PHQREKIDKEIELHRLLH-HKHVVQFY-HYFEDK---ENIYILLEYCSRRSMAHILKARK 172 Query: 1053 TAGFYDDEQVALIFRDICNAVFAMHCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTN 1232 + +V R I + + +H Q + HRDLK N + K+ DFG + Sbjct: 173 VL---TEPEVRYYLRQIVSGLKYLHEQE--ILHRDLKLGNFFINEAMELKVGDFGLAARL 227 Query: 1233 HKCFDKPEERGIEEDIIRKHT---TPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICY 1403 +P E R+ T TP Y +PE+ + S DIWALGC+MY + Sbjct: 228 -----EPLEH-------RRRTICGTPNYLSPEVLNKQGHGCES---DIWALGCVMYTMLL 272 Query: 1404 LKSAFD----GESKLQILNGNYRIPELPKYCSSITSLIEEMLQSSPDARPDITQV 1556 + F+ E+ I Y +P + LI ML +P+ RP + + Sbjct: 273 GRPPFETTNLKETYRCIREARYTMPS--SLLAPAKHLIASMLSKNPEDRPSLDDI 325
>Q9NYY3:PLK2_HUMAN Serine/threonine-protein kinase PLK2 - Homo sapiens (Human)| Length = 685 Score = 68.2 bits (165), Expect = 2e-10 Identities = 85/295 (28%), Positives = 125/295 (42%), Gaps = 12/295 (4%) Frame = +3 Query: 708 HSGPSGGLEGRTIDVGNVKVHVR-EAIAEGGFSCVYLARDLTNPAKHYALK---HVIVQD 875 HSGP + +D K + R + + +GGF+ Y DLTN K YA K H V Sbjct: 64 HSGPE--ISRIIVDPTTGKRYCRGKVLGKGGFAKCYEMTDLTNN-KVYAAKIIPHSRVAK 120 Query: 876 KESLDLVHKEITVMRALKGHPNVVTLVAHTILDMGRGREALLLMEFCER-SLVSALDARG 1052 + + KEI + R L H +VV H D +L+E+C R S+ L AR Sbjct: 121 PHQREKIDKEIELHRILH-HKHVVQFY-HYFEDK---ENIYILLEYCSRRSMAHILKARK 175 Query: 1053 TAGFYDDEQVALIFRDICNAVFAMHCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTN 1232 + +V R I + + +H Q + HRDLK N + K+ DFG + Sbjct: 176 VL---TEPEVRYYLRQIVSGLKYLHEQE--ILHRDLKLGNFFINEAMELKVGDFGLAARL 230 Query: 1233 HKCFDKPEERGIEEDIIRKHT---TPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICY 1403 +P E R+ T TP Y +PE+ + S DIWALGC+MY + Sbjct: 231 -----EPLEH-------RRRTICGTPNYLSPEVLNKQGHGCES---DIWALGCVMYTMLL 275 Query: 1404 LKSAFD----GESKLQILNGNYRIPELPKYCSSITSLIEEMLQSSPDARPDITQV 1556 + F+ E+ I Y +P + LI ML +P+ RP + + Sbjct: 276 GRPPFETTNLKETYRCIREARYTMPS--SLLAPAKHLIASMLSKNPEDRPSLDDI 328
>P10676:NINAC_DROME Neither inactivation nor afterpotential protein C - Drosophila| melanogaster (Fruit fly) Length = 1501 Score = 68.2 bits (165), Expect = 2e-10 Identities = 72/280 (25%), Positives = 122/280 (43%), Gaps = 15/280 (5%) Frame = +3 Query: 762 KVHVREAIAEGGFSCVYLARDLTNPAKHYALKHVIVQDKESLDLVHKEITVMRALKGHPN 941 K + E IA+G + V+ A++L N + ALK + D+E + +E +R HPN Sbjct: 15 KFEIYEEIAQGVNAKVFRAKELDND-RIVALK-IQHYDEEHQVSIEEEYRTLRDYCDHPN 72 Query: 942 VVTLVAHTILDMGRGREAL-LLMEFCERSLVSALDARGTAGFYD----DEQVALIFRDIC 1106 + L G + + +ME+C +A+D D +E +A I R+ C Sbjct: 73 LPEFYGVYKLSKPNGPDEIWFVMEYCAGG--TAVDMVNKLLKLDRRMREEHIAYIIRETC 130 Query: 1107 NAVFAMHCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIR 1286 A A+ V HRD++ +N+LL +G KLCDFG R ++ + + Sbjct: 131 RA--AIELNRNHVLHRDIRGDNILLTKNGRVKLCDFGL------------SRQVDSTLGK 176 Query: 1287 KHT---TPAYRAPEMWDLY--RREVISEKVDIWALGCLMYRICYLKSAF----DGESKLQ 1439 + T +P + APE+ R I+ + D+WALG + K F + Q Sbjct: 177 RGTCIGSPCWMAPEVVSAMESREPDITVRADVWALGITTIELADGKPPFADMHPTRAMFQ 236 Query: 1440 IL-NGNYRIPELPKYCSSITSLIEEMLQSSPDARPDITQV 1556 I+ N + + I I E L+ + + RP + ++ Sbjct: 237 IIRNPPPTLMRPTNWSQQINDFISESLEKNAENRPMMVEM 276
>Q14680:MELK_HUMAN Maternal embryonic leucine zipper kinase - Homo sapiens (Human)| Length = 651 Score = 68.2 bits (165), Expect = 2e-10 Identities = 79/293 (26%), Positives = 140/293 (47%), Gaps = 14/293 (4%) Frame = +3 Query: 771 VREAIAEGGFSCVYLARDLTNPAKHYALKHVIVQDKESL--DL--VHKEITVMRALKGHP 938 + E I GGF+ V LA + + A+K + DK +L DL + EI ++ L+ H Sbjct: 13 LHETIGTGGFAKVKLACHILT-GEMVAIK---IMDKNTLGSDLPRIKTEIEALKNLR-HQ 67 Query: 939 NVVTLVAHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVF 1118 ++ L + +L+ + +++E+C D + +E+ ++FR I +AV Sbjct: 68 HICQL--YHVLETAN--KIFMVLEYCPGG--ELFDYIISQDRLSEEETRVVFRQIVSAVA 121 Query: 1119 AMHCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHT- 1295 +H Q AHRDLK EN+L KL DFG + KP +G ++ ++ Sbjct: 122 YVHSQG--YAHRDLKPENLLFDEYHKLKLIDFGLCA-------KP--KGNKDYHLQTCCG 170 Query: 1296 TPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKL----QILNGNYRI 1463 + AY APE+ + + + + D+W++G L+Y + FD ++ + +I+ G Y Sbjct: 171 SLAYAAPEL--IQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKY-- 226 Query: 1464 PELPKYCS-SITSLIEEMLQSSPDARPDITQV----WFRVNELLPLELQKDLP 1607 ++PK+ S S L+++MLQ P R + + W + P+E Q P Sbjct: 227 -DVPKWLSPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQDYNYPVEWQSKNP 278
>Q9C9U2:CDKD1_ARATH Cyclin-dependent kinase D-1 - Arabidopsis thaliana (Mouse-ear cress)| Length = 398 Score = 68.2 bits (165), Expect = 2e-10 Identities = 62/237 (26%), Positives = 106/237 (44%), Gaps = 2/237 (0%) Frame = +3 Query: 774 REAIAEGGFSCVYLARDLTNPAKHYALKHVIVQDKESLDLVH-KEITVMRALKGHPNVVT 950 RE + +G + V+ A D N K + ++KE +++ +EI +++ LK HP+++ Sbjct: 14 REVLGQGTYGVVFKATDTKNGETVAIKKIRLGKEKEGVNVTALREIKLLKELK-HPHIIE 72 Query: 951 LVAHTILDMGRGREAL-LLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAMH 1127 L+ D +E L ++ EF E L + + R + V + I + + Sbjct: 73 LI-----DAFPHKENLHIVFEFMETDLEAVIRDRNL--YLSPGDVKSYLQMILKGL--EY 123 Query: 1128 CQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHTTPAY 1307 C V HRD+K N+L+G +G KL DFG + F P + + R Y Sbjct: 124 CHGKWVLHRDMKPNNLLIGPNGQLKLADFGLA----RIFGSPGRKFTHQVFAR-----WY 174 Query: 1308 RAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQILNGNYRIPELPK 1478 RAPE+ L+ + VD+WA GC+ + + G S + L+ + PK Sbjct: 175 RAPEL--LFGAKQYDGAVDVWAAGCIFAELLLRRPFLQGNSDIDQLSKIFAAFGTPK 229
>Q91727:CDK4_XENLA Cell division protein kinase 4 - Xenopus laevis (African clawed frog)| Length = 319 Score = 68.2 bits (165), Expect = 2e-10 Identities = 70/239 (29%), Positives = 113/239 (47%), Gaps = 8/239 (3%) Frame = +3 Query: 783 IAEGGFSCVYLARDLTNPAKHYALKHVIVQDKES---LDLVHKEITVMRALK--GHPNVV 947 I G + VY ARDL + K ALK+V VQ E+ L V +E+T+++ L+ HPN+V Sbjct: 15 IGVGAYGTVYKARDLQS-GKFVALKNVRVQTNENGLPLSTV-REVTLLKRLEHFDHPNIV 72 Query: 948 TLV---AHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVF 1118 L+ A D R + L+ E ++ L + L G E + + + + + Sbjct: 73 KLMDVCASARTD--RETKVTLVFEHVDQDLKTYLSKVPPPGL-PLETIKDLMKQFLSGLE 129 Query: 1119 AMHCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHTT 1298 +H + HRDLK EN+L+ + G KL DFG ++ + C + + ++ T Sbjct: 130 FLHLNC--IVHRDLKPENILVTSGGQVKLADFG-LARIYSC-----QMALTPVVV----T 177 Query: 1299 PAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQILNGNYRIPELP 1475 YRAPE + + + VD+W+ GC+ + K F G S+ L + I LP Sbjct: 178 LWYRAPE---VLLQSTYATPVDVWSAGCIFAEMFKRKPLFCGNSEADQLCKIFDIIGLP 233
>Q9DGA5:CDC2_ORYCU Cell division control protein 2 homolog - Oryzias curvinotus (Hynann| ricefish) Length = 303 Score = 68.2 bits (165), Expect = 2e-10 Identities = 64/225 (28%), Positives = 100/225 (44%), Gaps = 2/225 (0%) Frame = +3 Query: 777 EAIAEGGFSCVYLARDLTNPAKHYALKHVIVQDKES--LDLVHKEITVMRALKGHPNVVT 950 E I EG + VY R + + A+K + ++ +E +E+++++ LK HPNVV Sbjct: 8 EKIGEGTYGVVYKGRHKST-GQVVAMKKIRLESEEEGVPSTAVREVSLLQELK-HPNVVR 65 Query: 951 LVAHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNAVFAMHC 1130 L+ ++ R L+ EF L LD+ + + D V I ++ C Sbjct: 66 LL-DVLMQESR---LYLIFEFLSMDLKKYLDSIPSGQYMDPMLVKSYLYQILEGIY--FC 119 Query: 1131 QTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHTTPAYR 1310 V HRDLK +N+L+ G KL DFG + F P E + T YR Sbjct: 120 HRRRVLHRDLKPQNLLIDNKGVIKLADFGL----SRAFGVPVRVYTHEVV-----TLWYR 170 Query: 1311 APEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQIL 1445 APE+ L S VD+W+ G + + K F G+S++ L Sbjct: 171 APEV--LLGSPRYSTPVDVWSTGTIFAELATKKPLFHGDSEIDQL 213
>Q27032:CDC2H_THEPA Cell division control protein 2 homolog - Theileria parva| Length = 298 Score = 68.2 bits (165), Expect = 2e-10 Identities = 67/241 (27%), Positives = 109/241 (45%), Gaps = 3/241 (1%) Frame = +3 Query: 762 KVHVREAIAEGGFSCVYLARDLTNPAKHYALKHVIVQDKES--LDLVHKEITVMRALKGH 935 + H E I EG + VY A++ N + ALK + V++++ +EI++++ L H Sbjct: 3 RYHKMEKIGEGTYGVVYKAQN--NHGEICALKKIRVEEEDEGIPSTAIREISLLKELH-H 59 Query: 936 PNVVTLVAHTILDMGRGREAL-LLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNA 1112 PN+V L D+ + L L+ E+ ++ L LDA G + I Sbjct: 60 PNIVWL-----RDVIHSEKCLTLVFEYLDQDLKKLLDA--CDGGLEPTTAKSFLYQILRG 112 Query: 1113 VFAMHCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKH 1292 + +C + HRDLK +N+L+ +G KL DFG + F P E + Sbjct: 113 I--SYCHDHRILHRDLKPQNLLINREGVLKLADFGLA----RAFAIPVRSYTHEVV---- 162 Query: 1293 TTPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQILNGNYRIPEL 1472 T YRAP++ L + S VDIW++GC+ + F G S+ L ++I Sbjct: 163 -TLWYRAPDV--LMGSKKYSTAVDIWSVGCIFAEMINGVPLFPGISEQDQLKRIFKILGT 219 Query: 1473 P 1475 P Sbjct: 220 P 220
>Q26671:CDC2H_THEAN Cell division control protein 2 homolog - Theileria annulata| Length = 298 Score = 68.2 bits (165), Expect = 2e-10 Identities = 67/241 (27%), Positives = 109/241 (45%), Gaps = 3/241 (1%) Frame = +3 Query: 762 KVHVREAIAEGGFSCVYLARDLTNPAKHYALKHVIVQDKES--LDLVHKEITVMRALKGH 935 + H E I EG + VY A++ N + ALK + V++++ +EI++++ L H Sbjct: 3 RYHKMEKIGEGTYGVVYKAQN--NHGEICALKKIRVEEEDEGIPSTAIREISLLKELH-H 59 Query: 936 PNVVTLVAHTILDMGRGREAL-LLMEFCERSLVSALDARGTAGFYDDEQVALIFRDICNA 1112 PN+V L D+ + L L+ E+ ++ L LDA G + I Sbjct: 60 PNIVWL-----RDVIHSEKCLTLVFEYLDQDLKKLLDA--CDGGLEPTTAKSFLYQILRG 112 Query: 1113 VFAMHCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKH 1292 + +C + HRDLK +N+L+ +G KL DFG + F P E + Sbjct: 113 I--SYCHDHRILHRDLKPQNLLINREGVLKLADFGLA----RAFAIPVRSYTHEVV---- 162 Query: 1293 TTPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQILNGNYRIPEL 1472 T YRAP++ L + S VDIW++GC+ + F G S+ L ++I Sbjct: 163 -TLWYRAPDV--LMGSKKYSTAVDIWSVGCIFAEMINGVPLFPGISEQDQLKRIFKILGT 219 Query: 1473 P 1475 P Sbjct: 220 P 220
>Q9UQB9:AURKC_HUMAN Serine/threonine-protein kinase 13 - Homo sapiens (Human)| Length = 309 Score = 68.2 bits (165), Expect = 2e-10 Identities = 76/270 (28%), Positives = 114/270 (42%), Gaps = 12/270 (4%) Frame = +3 Query: 783 IAEGGFSCVYLARDLTNPAKHYALKHVIVQDKESLDLVH---KEITVMRALKGHPNVVTL 953 + +G F VYLAR L ALK + E L H +EI + L+ HPN++ L Sbjct: 49 LGKGKFGNVYLAR-LKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQ-HPNILRL 106 Query: 954 VAHTILDMGRGREALLLMEFCERS-LVSALDARGTAGFYDDEQVALIFRDICNAVFAMHC 1130 + R L++E+ R L L D+++ A I ++ +A+ +C Sbjct: 107 YNY----FHDARRVYLILEYAPRGELYKELQKSEKL---DEQRTATIIEELADAL--TYC 157 Query: 1131 QTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHT---TP 1301 V HRD+K EN+LLG G K+ DFG + +R+ T T Sbjct: 158 HDKKVIHRDIKPENLLLGFRGEVKIADFG--------------WSVHTPSLRRKTMCGTL 203 Query: 1302 AYRAPEMWDLYRREVISEKVDIWALGCLMYRICY----LKSAFDGESKLQILNGNYRIP- 1466 Y PEM EKVD+W +G L Y + +SA E+ +IL + R P Sbjct: 204 DYLPPEM---IEGRTYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPL 260 Query: 1467 ELPKYCSSITSLIEEMLQSSPDARPDITQV 1556 +P LI +L+ P R + Q+ Sbjct: 261 SMP---LGARDLISRLLRYQPLERLPLAQI 287
>Q5UQG7:YR818_MIMIV Putative serine/threonine-protein kinase/receptor R818 precursor -| Mimivirus Length = 1651 Score = 67.8 bits (164), Expect = 3e-10 Identities = 46/158 (29%), Positives = 78/158 (49%), Gaps = 5/158 (3%) Frame = +3 Query: 1122 MHCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHTTP 1301 +H P + HRD+K N+L+ K+ DFG F + +E E ++ + TP Sbjct: 1504 LHNSDPIIIHRDIKPSNILVDDSMNVKIADFG--------FARIKE---ENSVMTRCGTP 1552 Query: 1302 AYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDG----ESKLQILNGNYRIPE 1469 + APE + R E +EKVD+++ G +M+ + K F G + + IL G P+ Sbjct: 1553 CWTAPE---IIRGEKYTEKVDVFSFGIVMWEVLTCKEPFSGCNFMKVSMDILEG--ARPQ 1607 Query: 1470 LPKYCS-SITSLIEEMLQSSPDARPDITQVWFRVNELL 1580 +P C T L+++ + PD RP + V +N++L Sbjct: 1608 IPSDCPIDFTKLMKQCWHAKPDKRPSMEDVIMGLNDML 1645 Score = 38.1 bits (87), Expect = 0.22 Identities = 57/239 (23%), Positives = 101/239 (42%), Gaps = 12/239 (5%) Frame = +3 Query: 900 KEITVMRALKGHPNVVTLVAHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDDEQ 1079 +EI M +L+ HPNVV +A + R ++MEF SL S D G + Sbjct: 837 QEIHRMTSLR-HPNVVLFMAAST----RPPNMCIVMEFM--SLGSLYDLLGNELVTEIPP 889 Query: 1080 VALIFRDICNAVFAMH-CQTPPVAHRDLKAENVLLGADGAWKLCDFG--SVSTNHKCFDK 1250 V I R A MH + + HRDLK+ N+LL + K+ DFG + N+K Sbjct: 890 VLRI-RIAYQAAKGMHFLHSSDIVHRDLKSLNLLLDSKWNVKVSDFGLTKIKDNNKGKSS 948 Query: 1251 PEERGIEEDIIRKHTTPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGES 1430 +E + + + APE+ ++++ D+++ G +M+ + + G S Sbjct: 949 TKEDSV--------CSIQWTAPEVLS-EKQDIDYILADVYSFGIIMWELMTRLRPYIGLS 999 Query: 1431 ----KLQILNGNYRIPELPK-----YCSSITSLIEEMLQSSPDARPDITQVWFRVNELL 1580 + ++ N R PE+ + S L+ RP ++ +++ L+ Sbjct: 1000 PAAIAVAVIRDNLR-PEIQEEDINLMSSDYVELVNICWHKDTMIRPSFLEIMTKLSTLI 1057
>Q9H0K1:SN1L2_HUMAN Serine/threonine-protein kinase SNF1-like kinase 2 - Homo sapiens| (Human) Length = 926 Score = 67.8 bits (164), Expect = 3e-10 Identities = 82/320 (25%), Positives = 139/320 (43%), Gaps = 17/320 (5%) Frame = +3 Query: 738 RTIDVGNVKV---HVREAIAEGGFSCVYLARDLTNPAKHYALKHVIVQDKESLDLV---- 896 R + G V+V + + +G F+ V L R + A+K + DK LD V Sbjct: 8 RHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTE-VAIKII---DKSQLDAVNLEK 63 Query: 897 -HKEITVMRALKGHPNVVTLVAHTILDMGRGREALLLMEFCERSLVSALDARGTAGFYDD 1073 ++E+ +M+ L HP+++ L M L+ E+ + + D G ++ Sbjct: 64 IYREVQIMKMLD-HPHIIKLYQV----METKSMLYLVTEYAKNGEI--FDYLANHGRLNE 116 Query: 1074 EQVALIFRDICNAVFAMHCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKP 1253 + F I +AV +C + HRDLKAEN+LL + K+ DFG F Sbjct: 117 SEARRKFWQILSAVD--YCHGRKIVHRDLKAENLLLDNNMNIKIADFG--------FGNF 166 Query: 1254 EERGIEEDIIRKHTTPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGES- 1430 + G E + +P Y APE+++ + E ++DIW++G ++Y + FDG + Sbjct: 167 FKSG--ELLATWCGSPPYAAPEVFEGQQYE--GPQLDIWSMGVVLYVLVCGALPFDGPTL 222 Query: 1431 ---KLQILNGNYRIPELPKYCSSITSLIEEMLQSSPDARPDITQVWFRVNELLPLELQKD 1601 + ++L G +RIP LI ML P R I Q+ L+ + +Q+ Sbjct: 223 PILRQRVLEGRFRIPYF--MSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRP 280 Query: 1602 L-----PDGSPSGSAFELQI 1646 + + PS F Q+ Sbjct: 281 VLYPQEQENEPSIGEFNEQV 300
>Q9VPC0:KP58_DROME Serine/threonine-protein kinase PITSLRE - Drosophila melanogaster| (Fruit fly) Length = 952 Score = 67.8 bits (164), Expect = 3e-10 Identities = 70/232 (30%), Positives = 110/232 (47%), Gaps = 10/232 (4%) Frame = +3 Query: 783 IAEGGFSCVYLARDL-TNPAKHYALKHVIVQ-DKESLDLVH-KEITVMRALKG-HPNVVT 950 I EG + VY A+D TN ALK + ++ +KE + +EI + LKG HPN+VT Sbjct: 564 IEEGTYGVVYRAKDKRTNEI--VALKRLKMEKEKEGFPITSLREINTL--LKGQHPNIVT 619 Query: 951 LVAHTILDMGRGREALLLMEFCERSLVSALDARGTA--GFYDDEQVALIFRDICNAVFAM 1124 + I+ + ++M++ E L S ++ F+ E V + + + AV + Sbjct: 620 V--REIVVGSNMDKIFIVMDYVEHDLKSLMETMKNRKQSFFPGE-VKCLTQQLLRAVAHL 676 Query: 1125 HCQTPPVAHRDLKAENVLLGADGAWKLCDFGSVSTNHKCFDKPEERGIEEDIIRKHT--- 1295 H + HRDLK N+LL G K+ DFG + P I+K+T Sbjct: 677 HDNW--ILHRDLKTSNLLLSHKGILKVGDFGLARE----YGSP---------IKKYTSLV 721 Query: 1296 -TPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGESKLQILN 1448 T YRAPE+ L V S +D+W++GC+ + F G+S++ LN Sbjct: 722 VTLWYRAPEL--LLCSPVYSTPIDVWSVGCIFAEFLQMLPLFPGKSEIDELN 771
>Q10452:GSK3_SCHPO Protein kinase gsk3 - Schizosaccharomyces pombe (Fission yeast)| Length = 387 Score = 67.8 bits (164), Expect = 3e-10 Identities = 74/306 (24%), Positives = 133/306 (43%), Gaps = 9/306 (2%) Frame = +3 Query: 732 EGRTIDVGNVKVHVREAIAEGGFSCVYLARDLTNPAKHYALKHVIVQDKESLDLVHKEIT 911 +G T +V + + + G F V + + +K A+K V+ QDK ++E+ Sbjct: 21 DGSTGEVKQLSYTSSKVVGSGSFGVVMQVHLIESDSKA-AIKRVL-QDKR---FKNRELQ 75 Query: 912 VMRALKGHPNVVTLVAHTILDMGRGREALL--LMEFCERSLVSALDARGTAGFYDDEQVA 1085 +MR +K HPN+V L+A+ E L ++EF ++ A + Y ++++ Sbjct: 76 IMRIMK-HPNIVDLIAYYYTTGDNSDEVYLNLVLEFMPETIYRA------SRLYTRQKLS 128 Query: 1086 LIFRDICNAVFAM-----HCQTPPVAHRDLKAENVLLGAD-GAWKLCDFGSVSTNHKCFD 1247 + ++ ++ + + + HRD+K +N+LL + G KLCDFGS Sbjct: 129 MPMLEVKLYIYQLLRSLAYIHASGICHRDIKPQNLLLDPENGILKLCDFGSAKI------ 182 Query: 1248 KPEERGIEEDIIRKHTTPAYRAPEMWDLYRREVISEKVDIWALGCLMYRICYLKSAFDGE 1427 E + + YRAPE+ ++ + +DIW+ GC+M + F GE Sbjct: 183 ----LVAGEPNVSYICSRYYRAPEL--IFGATDYTHAIDIWSTGCVMAELMLGHPLFPGE 236 Query: 1428 SKLQILNGNYRIPELPKYCSSITSLIEEMLQSSPDARPD-ITQVWFRVNELLPLELQKDL 1604 S + L +I P T M P RP +++V+ R L L+L + Sbjct: 237 SGIDQLVEIIKILGTPSREQIKTMNPNYMEHRFPQIRPQPLSRVFSRSVPLDALDLLSKM 296 Query: 1605 PDGSPS 1622 +P+ Sbjct: 297 LQYTPT 302 Database: uniprot_sprot.fasta.out Posted date: Jul 19, 2007 5:58 PM Number of letters in database: 100,686,439 Number of sequences in database: 274,295 Lambda K H 0.318 0.134 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 274295 Number of Hits to DB: 544,559,592 Number of extensions: 12573686 Number of successful extensions: 43814 Number of sequences better than 10.0: 2276 Number of HSP's gapped: 42284 Number of HSP's successfully gapped: 2327 Length of query: 1020 Length of database: 100,686,439 Length adjustment: 123 Effective length of query: 897 Effective length of database: 66,948,154 Effective search space: 60052494138 Effective search space used: 60052494138 Neighboring words threshold: 12 Window for multiple hits: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)
