>Q28891:S5A1_MACFA 3-oxo-5-alpha-steroid 4-dehydrogenase 1 - Macaca fascicularis (Crab|
           eating macaque) (Cynomolgus monkey)
          Length = 263
 Score = 92.0 bits (227), Expect = 1e-18
 Identities = 54/127 (42%), Positives = 73/127 (57%), Gaps = 1/127 (0%)
 Frame = +3

Query: 93  YAQHLAVGLPDPTTDLLYP-GVLLFTVGIAGNFYHHYLLSQLRKGGDDDKGYKIPKGGLF 269
           Y  H AV   D  TD  +  G  L+  G+  N +  ++L  LRK GD   GYKIP+GGLF
Sbjct: 138 YLSHWAVYADDWVTDPRFLIGFGLWLAGMLINIHSDHILRNLRKPGDT--GYKIPRGGLF 195

Query: 270 EFVTCPHYLFEIIGFFGFAMISQTVYALAMASGTAAYLIGRSFATRRWYESKFEEFPTTI 449
           E+VT  +Y  EI+ + G+A+ S +V   A A  T  +L GR+    RWY  KFEE+P   
Sbjct: 196 EYVTAANYFGEIMEWCGYALASWSVQGAAFAFFTFCFLSGRAKEHHRWYLQKFEEYPKFR 255

Query: 450 KALIPYI 470
           K LIP++
Sbjct: 256 KILIPFL 262

>P18405:S5A1_HUMAN 3-oxo-5-alpha-steroid 4-dehydrogenase 1 - Homo sapiens (Human)|
          Length = 259

 Score = 89.4 bits (220), Expect = 9e-18
 Identities = 52/127 (40%), Positives = 72/127 (56%), Gaps = 1/127 (0%)
 Frame = +3

Query: 93  YAQHLAVGLPDPTTDLLYP-GVLLFTVGIAGNFYHHYLLSQLRKGGDDDKGYKIPKGGLF 269
           Y  H AV   D  TD  +  G  L+  G+  N +  ++L  LRK GD   GYKIP+GGLF
Sbjct: 134 YLSHCAVYADDWVTDPRFLIGFGLWLTGMLINIHSDHILRNLRKPGDT--GYKIPRGGLF 191

Query: 270 EFVTCPHYLFEIIGFFGFAMISQTVYALAMASGTAAYLIGRSFATRRWYESKFEEFPTTI 449
           E+VT  +Y  EI+ + G+A+ S +V   A A  T  +L GR+     WY  KFEE+P   
Sbjct: 192 EYVTAANYFGEIMEWCGYALASWSVQGAAFAFFTFCFLSGRAKEHHEWYLRKFEEYPKFR 251

Query: 450 KALIPYI 470
           K +IP++
Sbjct: 252 KIIIPFL 258

>P24008:S5A1_RAT 3-oxo-5-alpha-steroid 4-dehydrogenase 1 - Rattus norvegicus (Rat)|
          Length = 259

 Score = 86.3 bits (212), Expect = 8e-17
 Identities = 47/128 (36%), Positives = 74/128 (57%), Gaps = 1/128 (0%)
 Frame = +3

Query: 93  YAQHLAVGLPDPTTDLLY-PGVLLFTVGIAGNFYHHYLLSQLRKGGDDDKGYKIPKGGLF 269
           Y    AV   D  T   +  G  L+ VG+  N +  ++L  LRK G+   GYKIP+GGLF
Sbjct: 134 YLSQFAVYAEDWVTHPCFLTGFALWLVGMVINIHSDHILRNLRKPGET--GYKIPRGGLF 191

Query: 270 EFVTCPHYLFEIIGFFGFAMISQTVYALAMASGTAAYLIGRSFATRRWYESKFEEFPTTI 449
           E+V+  +Y  E++ + GFA+ S ++  +  A  T + L+ R+    +WY  KFE++P + 
Sbjct: 192 EYVSAANYFGELVEWCGFALASWSLQGVVFALFTLSTLLTRAKQHHQWYHEKFEDYPKSR 251

Query: 450 KALIPYIL 473
           K LIP++L
Sbjct: 252 KILIPFVL 259

>Q28892:S5A2_MACFA 3-oxo-5-alpha-steroid 4-dehydrogenase 2 - Macaca fascicularis (Crab|
           eating macaque) (Cynomolgus monkey)
          Length = 254

 Score = 84.7 bits (208), Expect = 2e-16
 Identities = 46/107 (42%), Positives = 70/107 (65%)
 Frame = +3

Query: 150 GVLLFTVGIAGNFYHHYLLSQLRKGGDDDKGYKIPKGGLFEFVTCPHYLFEIIGFFGFAM 329
           GV LF +G+  N +  Y+L QLRK G+    Y+IPKGGLF +V+  ++L EII + G+A+
Sbjct: 149 GVFLFILGMGVNIHSDYILRQLRKPGEIT--YRIPKGGLFTYVSGANFLGEIIEWIGYAL 206

Query: 330 ISQTVYALAMASGTAAYLIGRSFATRRWYESKFEEFPTTIKALIPYI 470
            + ++ ALA A  +  +L  R+F   R+Y   FE++P + KALIP+I
Sbjct: 207 ATWSLPALAFAFFSVCFLGLRAFHHHRFYLKMFEDYPKSRKALIPFI 253

>O18765:S5A2_PIG 3-oxo-5-alpha-steroid 4-dehydrogenase 2 - Sus scrofa (Pig)|
          Length = 254

 Score = 83.6 bits (205), Expect = 5e-16
 Identities = 48/114 (42%), Positives = 74/114 (64%), Gaps = 1/114 (0%)
 Frame = +3

Query: 132 TDLLYP-GVLLFTVGIAGNFYHHYLLSQLRKGGDDDKGYKIPKGGLFEFVTCPHYLFEII 308
           TD+ +  GV LF +G+  N +  Y+L QLRK G+    YKIP+GGLF +V+  ++L EII
Sbjct: 142 TDIRFSLGVFLFILGMGINIHSDYILRQLRKPGEVI--YKIPQGGLFTYVSGANFLGEII 199

Query: 309 GFFGFAMISQTVYALAMASGTAAYLIGRSFATRRWYESKFEEFPTTIKALIPYI 470
            + G+A+ + ++ ALA A  +  +L  R+F   R+Y   FE++P + KALIP+I
Sbjct: 200 EWIGYALATWSLPALAFAFFSLCFLGLRAFHHHRFYVKMFEDYPKSRKALIPFI 253

>P31213:S5A2_HUMAN 3-oxo-5-alpha-steroid 4-dehydrogenase 2 - Homo sapiens (Human)|
          Length = 254

 Score = 83.2 bits (204), Expect = 6e-16
 Identities = 47/114 (41%), Positives = 74/114 (64%), Gaps = 1/114 (0%)
 Frame = +3

Query: 132 TDLLYP-GVLLFTVGIAGNFYHHYLLSQLRKGGDDDKGYKIPKGGLFEFVTCPHYLFEII 308
           TD+ +  GV LF +G+  N +  Y+L QLRK G+    Y+IP+GGLF +V+  ++L EII
Sbjct: 142 TDIRFSLGVFLFILGMGINIHSDYILRQLRKPGEIS--YRIPQGGLFTYVSGANFLGEII 199

Query: 309 GFFGFAMISQTVYALAMASGTAAYLIGRSFATRRWYESKFEEFPTTIKALIPYI 470
            + G+A+ + ++ ALA A  +  +L  R+F   R+Y   FE++P + KALIP+I
Sbjct: 200 EWIGYALATWSLPALAFAFFSLCFLGLRAFHHHRFYLKMFEDYPKSRKALIPFI 253

>P31214:S5A2_RAT 3-oxo-5-alpha-steroid 4-dehydrogenase 2 - Rattus norvegicus (Rat)|
          Length = 254

 Score = 79.3 bits (194), Expect = 9e-15
 Identities = 44/107 (41%), Positives = 68/107 (63%)
 Frame = +3

Query: 150 GVLLFTVGIAGNFYHHYLLSQLRKGGDDDKGYKIPKGGLFEFVTCPHYLFEIIGFFGFAM 329
           GV LF +G+  N +  Y L QLRK G+    Y+IP+GGLF +V+  ++L EII + G+A+
Sbjct: 149 GVFLFILGMGINIHSDYTLRQLRKPGEVI--YRIPRGGLFTYVSGANFLGEIIEWIGYAL 206

Query: 330 ISQTVYALAMASGTAAYLIGRSFATRRWYESKFEEFPTTIKALIPYI 470
            + +V A A A  T  +L  ++F   R+Y   F+++P + KALIP+I
Sbjct: 207 ATWSVPAFAFAFFTLCFLGMQAFYHHRFYLKMFKDYPKSRKALIPFI 253

>Q99N99:S5A2_MOUSE 3-oxo-5-alpha-steroid 4-dehydrogenase 2 - Mus musculus (Mouse)|
          Length = 254

 Score = 75.9 bits (185), Expect = 1e-13
 Identities = 49/150 (32%), Positives = 84/150 (56%), Gaps = 4/150 (2%)
 Frame = +3

Query: 33  PLNTALTISSSYLLSAITMIYAQHLAVGLPDPT---TDLLYP-GVLLFTVGIAGNFYHHY 200
           PL+  + + ++       ++ A +L      P    TD+ +  GV  F +G+  N +   
Sbjct: 106 PLSAVIFLKATAFCIGNGLLQAYYLVYCAEYPEEWYTDMRFSVGVFFFILGMGINIHSDC 165

Query: 201 LLSQLRKGGDDDKGYKIPKGGLFEFVTCPHYLFEIIGFFGFAMISQTVYALAMASGTAAY 380
           +L QLRK G+    Y+IP+GGLF +V+  ++L EII + G+A+ + +V A A A  T  +
Sbjct: 166 MLRQLRKPGEVI--YRIPQGGLFTYVSGANFLGEIIEWMGYALATWSVPAFAFAFFTLCF 223

Query: 381 LIGRSFATRRWYESKFEEFPTTIKALIPYI 470
           L  ++F   R+Y   F+++P + KALIP+I
Sbjct: 224 LGMQAFYHHRFYLKMFKDYPKSRKALIPFI 253

>Q38944:DET2_ARATH Probable steroid reductase DET2 - Arabidopsis thaliana (Mouse-ear|
           cress)
          Length = 262

 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 39/108 (36%), Positives = 66/108 (61%), Gaps = 1/108 (0%)
 Frame = +3

Query: 150 GVLLFTVGIAGNFYHHYLLSQLRKGGDDDKGYKIPKGGLFEFVTCPHYLFEIIGFFGFAM 329
           G+++F  G+  N      L +L+K  ++  GY IP+GG FE V+CP+Y  E I + G+A+
Sbjct: 156 GMVVFITGMYINITSDRTLVRLKK--ENRGGYVIPRGGWFELVSCPNYFGEAIEWLGWAV 213

Query: 330 ISQTVYALAMASGTAAYLIGRSFATRRWYESKF-EEFPTTIKALIPYI 470
           ++ +   +     T + L  R+ A+ +WY +KF EE+P T KA+IP++
Sbjct: 214 MTWSWAGIGFFLYTCSNLFPRARASHKWYIAKFKEEYPKTRKAVIPFV 261

>Q64232:GPSN2_RAT Synaptic glycoprotein SC2 - Rattus norvegicus (Rat)|
          Length = 308

 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 48/164 (29%), Positives = 70/164 (42%), Gaps = 7/164 (4%)
 Frame = +3

Query: 3   LFIHRYS-GNMPLNTALTISSSYLLSAITMIY-AQHLAVGLPDPTTDLLYPGVLLFTVGI 176
           LF+HR+S G MPL       + Y   A  M Y   H     P      +   + +F +  
Sbjct: 146 LFVHRFSHGTMPLRNIFKNCTYYWGFAAWMAYYINHPLYTPPTYGVQQVKLALAIFVICQ 205

Query: 177 AGNFYHHYLLSQLRKGGDDDKGYKIPKGG----LFEFVTCPHYLFEIIGFFGFAMISQTV 344
            GNF  H  L  LR  G   +    P       LF  V+CP+Y +E+  + GFA+++Q V
Sbjct: 206 LGNFSIHMALRDLRPAGSKTRKIPYPTKNPFTWLFLLVSCPNYTYEVGSWIGFAIMTQCV 265

Query: 345 -YALAMASGTAAYLIGRSFATRRWYESKFEEFPTTIKALIPYIL 473
             AL    G     I       R Y  +F ++P     +IP++L
Sbjct: 266 PVALFSLVGFTQMTIWAK-GKHRSYLKEFRDYPPLRMPIIPFLL 308

>Q9CY27:GPSN2_MOUSE Synaptic glycoprotein SC2 - Mus musculus (Mouse)|
          Length = 308

 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 48/164 (29%), Positives = 70/164 (42%), Gaps = 7/164 (4%)
 Frame = +3

Query: 3   LFIHRYS-GNMPLNTALTISSSYLLSAITMIY-AQHLAVGLPDPTTDLLYPGVLLFTVGI 176
           LF+HR+S G MPL       + Y   A  M Y   H     P      +   + +F +  
Sbjct: 146 LFVHRFSHGTMPLRNIFKNCTYYWGFAAWMAYYINHPLYTPPTYGVQQVKLALAVFVICQ 205

Query: 177 AGNFYHHYLLSQLRKGGDDDKGYKIPKGG----LFEFVTCPHYLFEIIGFFGFAMISQTV 344
            GNF  H  L  LR  G   +    P       LF  V+CP+Y +E+  + GFA+++Q V
Sbjct: 206 LGNFSIHMALRDLRPAGSKTRKIPYPTKNPFTWLFLLVSCPNYTYEVGSWIGFAILTQCV 265

Query: 345 -YALAMASGTAAYLIGRSFATRRWYESKFEEFPTTIKALIPYIL 473
             AL    G     I       R Y  +F ++P     +IP++L
Sbjct: 266 PVALFSLVGFTQMTIWAK-GKHRSYLKEFRDYPPLRMPIIPFLL 308

>Q9NZ01:GPSN2_HUMAN Synaptic glycoprotein SC2 - Homo sapiens (Human)|
          Length = 308

 Score = 57.0 bits (136), Expect = 5e-08
 Identities = 47/164 (28%), Positives = 70/164 (42%), Gaps = 7/164 (4%)
 Frame = +3

Query: 3   LFIHRYS-GNMPLNTALTISSSYLLSAITMIY-AQHLAVGLPDPTTDLLYPGVLLFTVGI 176
           LF+HR+S G MPL       + Y   A  M Y   H     P      +   + +F +  
Sbjct: 146 LFVHRFSHGTMPLRNIFKNCTYYWGFAAWMAYYINHPLYTPPTYGAQQVKLALAIFVICQ 205

Query: 177 AGNFYHHYLLSQLRKGGDDDKGYKIPKGG----LFEFVTCPHYLFEIIGFFGFAMISQTV 344
            GNF  H  L  LR  G   +    P       LF  V+CP+Y +E+  + GFA+++Q +
Sbjct: 206 LGNFSIHMALRDLRPAGSKTRKIPYPTKNPFTWLFLLVSCPNYTYEVGSWIGFAIMTQCL 265

Query: 345 -YALAMASGTAAYLIGRSFATRRWYESKFEEFPTTIKALIPYIL 473
             AL    G     I       R Y  +F ++P     +IP++L
Sbjct: 266 PVALFSLVGFTQMTIWAK-GKHRSYLKEFRDYPPLRMPIIPFLL 308

>P40526:DFG10_YEAST Protein DFG10 - Saccharomyces cerevisiae (Baker's yeast)|
          Length = 253

 Score = 50.4 bits (119), Expect = 5e-06
 Identities = 39/157 (24%), Positives = 69/157 (43%)
 Frame = +3

Query: 3   LFIHRYSGNMPLNTALTISSSYLLSAITMIYAQHLAVGLPDPTTDLLYPGVLLFTVGIAG 182
           L++  Y+ N  +N +  +   +  S + +I    L       T ++     ++F +    
Sbjct: 108 LYVLHYTSNSRMNWSHYLVGIWFYSVLLLILNISLYKNSIPNTLNM--NAFIIFCIASWD 165

Query: 183 NFYHHYLLSQLRKGGDDDKGYKIPKGGLFEFVTCPHYLFEIIGFFGFAMISQTVYALAMA 362
            + +H +L+ L K       Y +P G LF  V CPHYL EII +       Q  Y   + 
Sbjct: 166 QYKNHVILANLVK-------YSLPTGRLFRLVCCPHYLDEIIIYSTLLPYEQEFYLTLVW 218

Query: 363 SGTAAYLIGRSFATRRWYESKFEEFPTTIKALIPYIL 473
             T+  L   +  T+ +Y  KF++      A+IP+I+
Sbjct: 219 VITS--LTISALETKNYYRHKFKDNHVAPYAIIPFII 253

>Q99190:TSC13_YEAST Enoyl reductase TSC13 - Saccharomyces cerevisiae (Baker's yeast)|
          Length = 310

 Score = 33.9 bits (76), Expect = 0.45
 Identities = 27/111 (24%), Positives = 50/111 (45%), Gaps = 7/111 (6%)
 Frame = +3

Query: 159 LFTVGIAGNFYHHYLLSQLRKGGDDDKGY-----KIPKG-GLFEFVTCPHYLFEIIGFFG 320
           LF +    NFY H    +LR  GD  K +     ++P   G+F     P+Y FE+  +  
Sbjct: 209 LFVLSELWNFYCHI---KLRLWGDYQKKHGNAKIRVPLNQGIFNLFVAPNYTFEVWSWIW 265

Query: 321 FAMISQ-TVYALAMASGTAAYLIGRSFATRRWYESKFEEFPTTIKALIPYI 470
           F  + +  ++A+   + + A +         W + K +++ T    LIP++
Sbjct: 266 FTFVFKFNLFAVLFLTVSTAQMYA-------WAQKKNKKYHTRRAFLIPFV 309

>Q8NNP4:DPO4_CORGL DNA polymerase IV - Corynebacterium glutamicum (Brevibacterium|
           flavum)
          Length = 467

 Score = 31.6 bits (70), Expect = 2.2
 Identities = 19/57 (33%), Positives = 27/57 (47%)
 Frame = -2

Query: 173 ANGEEEHAWVEEIGCRVRESDGEVLCVDHGDGAEQVAGGDGERRVEWHVSTVPVDEE 3
           A  EE   W EE+   ++E  G    V  G G +    G GE + +  V  VPVD++
Sbjct: 116 ATPEEVKQWAEELRAEIKEVTGLPSSVGAGSGKQIAKIGSGEAKPD-GVFVVPVDKQ 171

>Q82IW0:DASR_STRAW HTH-type transcriptional repressor dasR - Streptomyces avermitilis|
          Length = 254

 Score = 31.2 bits (69), Expect = 2.9
 Identities = 19/53 (35%), Positives = 29/53 (54%)
 Frame = -2

Query: 491 QLTSSLQDIGYQSLDGCGELLELGFVPSTGGEASADEVRCRAGGHGERINSLR 333
           QLTS  +D+  Q L+   +LL++G++  T  +  A  +   AGG   RI  LR
Sbjct: 94  QLTSYTEDMRAQGLEPTSQLLDIGYI--TADDTLAGLLDITAGGRVLRIERLR 144

>Q9K492:DASR_STRCO HTH-type transcriptional repressor dasR - Streptomyces coelicolor|
          Length = 254

 Score = 30.8 bits (68), Expect = 3.8
 Identities = 19/53 (35%), Positives = 29/53 (54%)
 Frame = -2

Query: 491 QLTSSLQDIGYQSLDGCGELLELGFVPSTGGEASADEVRCRAGGHGERINSLR 333
           QLTS  +D+  Q L+   +LL++G++  T  +  A  +   AGG   RI  LR
Sbjct: 94  QLTSYTEDMRAQGLEPTSQLLDIGYI--TADDRLAGLLDITAGGRVLRIERLR 144

>Q8TUT9:TPIS_METKA Triosephosphate isomerase - Methanopyrus kandleri|
          Length = 226

 Score = 30.0 bits (66), Expect = 6.5
 Identities = 20/53 (37%), Positives = 26/53 (49%), Gaps = 3/53 (5%)
 Frame = -2

Query: 359 HGER---INSLRDHCKAEESDDLEEVVRAGDELEEPALGDLVPLIVITSLPEL 210
           H ER   +  L+D C+A  ++ L  +V A D L   A G L P  V    PEL
Sbjct: 96  HSERRMLLEDLKDVCRACINEGLLTIVCASDALAARAAGALSPHAVAVEPPEL 148

>Q8VV01:DASR_STRGR HTH-type transcriptional repressor dasR - Streptomyces griseus|
          Length = 253

 Score = 30.0 bits (66), Expect = 6.5
 Identities = 19/53 (35%), Positives = 28/53 (52%)
 Frame = -2

Query: 491 QLTSSLQDIGYQSLDGCGELLELGFVPSTGGEASADEVRCRAGGHGERINSLR 333
           QLTS  +D+  Q L+   +LL++G+V  T  +  A  +    GG   RI  LR
Sbjct: 93  QLTSYTEDMRAQGLEPTSQLLDIGYV--TADDTLAGLLDISTGGRVLRIERLR 143

>P01267:THYG_BOVIN Thyroglobulin precursor - Bos taurus (Bovine)|
          Length = 2769

 Score = 29.6 bits (65), Expect = 8.5
 Identities = 19/58 (32%), Positives = 24/58 (41%), Gaps = 11/58 (18%)
 Frame = -2

Query: 455 SLDGCGELLELGFVPSTGGEASADEVRCRAGG-----------HGERINSLRDHCKAE 315
           S  GCG+     FVP+   E S +EV+C AG             G R+   R  C  E
Sbjct: 603 SSQGCGQAPGSLFVPACTAEGSYEEVQCFAGDCWCVDAQGRELAGSRVRGGRPRCPTE 660

>Q20347:MKK4_CAEEL MAP kinase kinase mkk-4 - Caenorhabditis elegans|
          Length = 363

 Score = 29.6 bits (65), Expect = 8.5
 Identities = 18/67 (26%), Positives = 33/67 (49%)
 Frame = -2

Query: 485 TSSLQDIGYQSLDGCGELLELGFVPSTGGEASADEVRCRAGGHGERINSLRDHCKAEESD 306
           +++LQD+G       G + ++     TG   +   +RC   GH E+I  LR+H    +S+
Sbjct: 63  SANLQDLGAIGNGNFGTVYKMRH-KETGKLIAVKRIRCNNIGHREQIRLLREHDTIVKSE 121

Query: 305 DLEEVVR 285
               +V+
Sbjct: 122 KGPNIVK 128


  Database: uniprot_sprot.fasta.out
    Posted date:  Jul 19, 2007  5:58 PM
  Number of letters in database: 100,686,439
  Number of sequences in database:  274,295
  
Lambda     K      H
   0.318    0.134    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 274295
Number of Hits to DB: 99,662,113
Number of extensions: 2304885
Number of successful extensions: 6771
Number of sequences better than 10.0: 21
Number of HSP's gapped: 6760
Number of HSP's successfully gapped: 21
Length of query: 198
Length of database: 100,686,439
Length adjustment: 107
Effective length of query: 91
Effective length of database: 71,336,874
Effective search space: 6491655534
Effective search space used: 6491655534
Neighboring words threshold: 12
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)