>Q97ZF0:TOP6B_SULSO Type 2 DNA topoisomerase 6 subunit B - Sulfolobus solfataricus|
          Length = 530
 Score =  262 bits (670), Expect = 4e-69
 Identities = 156/436 (35%), Positives = 255/436 (58%), Gaps = 3/436 (0%)
 Frame = +2

Query: 560  FRVTCKDNGRGMPHEDIPNMFGRVLSGTKYGLRQTRGKFGLGAKMALIWSKMSTGLPIDI 739
            ++V   DNG G+P +++PN FGRVL  +KY  RQTRG +GLG K A+++S+M    PI+I
Sbjct: 70   YKVNVVDNGIGIPPQEVPNAFGRVLYSSKYVNRQTRGMYGLGVKAAVLYSQMHQDKPIEI 129

Query: 740  KSSMKGQDYITFCRLDIDIHKNVPHIHLHEKRENNGHWHGAEIQVIIEGNWTTHRSRILH 919
            ++S      +   +L IDI+KN P I      ENN  +HG  + + I G+W   +SRI  
Sbjct: 130  ETSPVNSKRLYTFKLKIDINKNEPIIVERGSVENNTGFHGTSVAISIPGDWPKAKSRIYE 189

Query: 920  YMRQMAVITPYAQFLFRFLSDAAEKNLTIKFARRTDVMPPVPLLTKHHPSAVDLLLIKRL 1099
            Y+++  +ITPYA+F+F+      E N+T  + R T+ +P  P   K HP  VD   IK +
Sbjct: 190  YIKRTYIITPYAEFIFK----DPEGNVTY-YPRLTNKIPKPPQEVKPHPYGVDREEIKIM 244

Query: 1100 ITDTTKP-NLLQFLQHEFVNISKAHADRLIGEMGPDFNAKTTVNSLTSQQLVRIHQLFRQ 1276
            I +  +   + +FL  EF +I    AD+++  +G   N K  V +LT +++ R+ + F++
Sbjct: 245  INNLKRDYTIKEFLMSEFQSIGDTTADKILELVGLRPNKK--VKNLTEEEITRLVETFKK 302

Query: 1277 AK-FDDPSGNCLSPAGEYNLRLGIIKELHPDLVATHASSPQVFEGHPFIVEAGVSIGGK- 1450
             + F  PS + LS  GE  + LG+ K  +PD  A+    P+ ++GHPFIVEAG++ GG  
Sbjct: 303  YEDFRSPSADSLSVIGEDLIELGLKKIFNPDFTASITRKPKAYQGHPFIVEAGIAFGGSI 362

Query: 1451 DVKQGLNIFRFANRIPLLFEQGADVITRTALKRINWSIYKINQQQDEIGVFVSIVSTKIP 1630
             V +   + R+AN+IPL++++ +DVI +  ++ ++W  Y I   Q ++ V V + STKIP
Sbjct: 363  PVGEEPIVLRYANKIPLIYDEKSDVIWK-VVEELDWKRYGIESDQYQMVVMVHLCSTKIP 421

Query: 1631 FKGTGKEYIGDDITEIADAVKSALKQCCVQLKSKIVKKLQAREQQDRKRNLNKYIPDVAR 1810
            +K  GKE I  ++ +I   +K+AL +   +LK  + +K + +E + +     KY+P+V+R
Sbjct: 422  YKSAGKESIA-EVEDIEKEIKNALMEVARKLKLYLSEKRKEQEAKKKLLAYLKYVPEVSR 480

Query: 1811 TIMETLGELADESPPK 1858
            ++   L     E  PK
Sbjct: 481  SLAIFLASGNKELVPK 496

>O05207:TOP6B_SULSH Type 2 DNA topoisomerase 6 subunit B - Sulfolobus shibatae|
          Length = 530

 Score =  261 bits (667), Expect = 1e-68
 Identities = 163/456 (35%), Positives = 262/456 (57%), Gaps = 3/456 (0%)
 Frame = +2

Query: 560  FRVTCKDNGRGMPHEDIPNMFGRVLSGTKYGLRQTRGKFGLGAKMALIWSKMSTGLPIDI 739
            ++V   DNG G+P +++PN FGRVL  +KY  RQTRG +GLG K A+++S+M    PI+I
Sbjct: 70   YKVNVVDNGIGIPPQEVPNAFGRVLYSSKYVNRQTRGMYGLGVKAAVLYSQMHQDKPIEI 129

Query: 740  KSSMKGQDYITFCRLDIDIHKNVPHIHLHEKRENNGHWHGAEIQVIIEGNWTTHRSRILH 919
            ++S      I   +L IDI+KN P I      EN   +HG  + + I G+W   +SRI  
Sbjct: 130  ETSPVNSKRIYTFKLKIDINKNEPIIVERGSVENTRGFHGTSVAISIPGDWPKAKSRIYE 189

Query: 920  YMRQMAVITPYAQFLFRFLSDAAEKNLTIKFARRTDVMPPVPLLTKHHPSAVDLLLIKRL 1099
            Y+++  +ITPYA+F+F+      E N+T  + R T+ +P  P   K HP  VD   IK L
Sbjct: 190  YIKRTYIITPYAEFIFK----DPEGNVTY-YPRLTNKIPKPPQEVKPHPYGVDREEIKIL 244

Query: 1100 ITDTTKP-NLLQFLQHEFVNISKAHADRLIGEMGPDFNAKTTVNSLTSQQLVRIHQLFRQ 1276
            I +  +   + +FL +EF +I    AD+++   G   N K  V +LT +++ R+ + F++
Sbjct: 245  INNLKRDYTIKEFLVNEFQSIGDTTADKILELAGLKPNKK--VKNLTEEEITRLVETFKK 302

Query: 1277 AK-FDDPSGNCLSPAGEYNLRLGIIKELHPDLVATHASSPQVFEGHPFIVEAGVSIGGK- 1450
             + F  PS + LS  GE  + LG+ K  +PD  A+    P+ ++GHPFIVEAGV+ GG  
Sbjct: 303  DEDFRSPSADSLSVIGEDLIELGLKKIFNPDFAASITRKPKAYQGHPFIVEAGVAFGGSI 362

Query: 1451 DVKQGLNIFRFANRIPLLFEQGADVITRTALKRINWSIYKINQQQDEIGVFVSIVSTKIP 1630
             V +   + R+AN+IPL++++ +DVI +  ++ ++W  Y I   Q ++ V V + STKIP
Sbjct: 363  PVGEEPIVLRYANKIPLIYDEKSDVIWK-VVEELDWKRYGIESDQYQMVVMVHLCSTKIP 421

Query: 1631 FKGTGKEYIGDDITEIADAVKSALKQCCVQLKSKIVKKLQAREQQDRKRNLNKYIPDVAR 1810
            +K  GKE I  ++  I   +K+AL +   +LK  + +K + +E + +     KYIP+V+R
Sbjct: 422  YKSAGKESIA-EVENIEKEIKNALMEVARKLKQYLSEKRKEQEAKKKLLAYLKYIPEVSR 480

Query: 1811 TIMETLGELADESPPKRPRFDKEDEELLEKINSEEV 1918
            ++   L     E   K   +  E  E L K+ S+++
Sbjct: 481  SLATFLASGNKELVSK---YQNEISEGLFKLISKKL 513

>Q9YE64:TOP6B_AERPE Type 2 DNA topoisomerase 6 subunit B - Aeropyrum pernix|
          Length = 568

 Score =  260 bits (665), Expect = 2e-68
 Identities = 152/464 (32%), Positives = 249/464 (53%), Gaps = 3/464 (0%)
 Frame = +2

Query: 536  KGRGEASFFRVTCKDNGRGMPHEDIPNMFGRVLSGTKYGLRQTRGKFGLGAKMALIWSKM 715
            +GRG    + VT +DNG G+P   +   FG+VL  +KY +RQTRG +GLG K A+++ +M
Sbjct: 88   EGRGGRPRYTVTVEDNGIGVPVTSMAMAFGKVLFSSKYVIRQTRGMYGLGVKAAILYGQM 147

Query: 716  STGLPIDIKSSMKGQDYITFCRLDIDIHKNVPHIHLHEKRENNGHWHGAEIQVIIEGNWT 895
            + G P+++ S+ KG  Y+   +L ID+ +N P I    +    G WHG  + + +EG+W+
Sbjct: 148  TAGTPVEVYSATKGSQYVYMMKLVIDVQRNEPRILERGEWNKRGSWHGTRVTLSLEGDWS 207

Query: 896  THRSRILHYMRQMAVITPYAQFLFRFLSDAAEKNLTIKFARRTDVMPPVPLLTKHHPSAV 1075
              +S+IL Y+++ AVI PYA+ +               F R T  +P  P  +K HP  V
Sbjct: 208  RAKSKILEYIKRTAVIAPYAEIILE-----TPDGEIYYFPRSTRKLPKPPRESKPHPHGV 262

Query: 1076 DLLLIKRLITDTTKPNLLQFLQHEFVNISKAHADRLIGEMG--PDFNAKTTVNSLTSQQL 1249
            D+  +K ++  T    L +FL  EF +I    A   + + G  PD   +  +     + L
Sbjct: 263  DIEQLKSMLRSTRASTLREFLVKEFQSIGDKTAQDFLEKYGLDPDLKPRELLKKGRDKLL 322

Query: 1250 VRIHQLFRQAKFDDPSGNCLSPAGEYNLRLGIIKELHPDLVATHASSPQVFEGHPFIVEA 1429
             R+     +  F  P  + LSP G   + +G+ +  +P+ V   + SP+ + GHPFIVE 
Sbjct: 323  RRLADALMEYPFRAPKSDYLSPIGSDIIEIGLRRMFNPEWVGAVSRSPKAYRGHPFIVEV 382

Query: 1430 GVSIGGK-DVKQGLNIFRFANRIPLLFEQGADVITRTALKRINWSIYKINQQQDEIGVFV 1606
            G++ GG  + +    + R+AN+IPLL+E+  DV +   +  INW  Y ++     + V V
Sbjct: 383  GIAYGGGIEARSEPLLLRYANKIPLLYEEREDV-SYKVVSSINWRQYNVDFPAPLV-VLV 440

Query: 1607 SIVSTKIPFKGTGKEYIGDDITEIADAVKSALKQCCVQLKSKIVKKLQAREQQDRKRNLN 1786
             I STK+P+KG GKE +  D+ EI   +++A+++   +L+  + +K +  E   R   L 
Sbjct: 441  HIASTKVPYKGVGKESV-SDVPEIEAEIRNAVQEVARRLRLYLSRKAREEEAIRRSVTLA 499

Query: 1787 KYIPDVARTIMETLGELADESPPKRPRFDKEDEELLEKINSEEV 1918
            KYIP+VA ++   L   +   PPK P   K+ +E L KI +  +
Sbjct: 500  KYIPEVAVSLAYFLRPPSKWQPPK-PEEVKKIQEALIKIVARHI 542

>Q971T2:TOP6B_SULTO Type 2 DNA topoisomerase 6 subunit B - Sulfolobus tokodaii|
          Length = 532

 Score =  257 bits (656), Expect = 2e-67
 Identities = 180/597 (30%), Positives = 289/597 (48%), Gaps = 18/597 (3%)
 Frame = +2

Query: 191  PAEFFAENKNIAGFDNPGKSLYTTMRELVENALDSAESISELPDXXXXXXXXXKSKFNTM 370
            PAEFF  N  +AGF NP ++LY T+RELVENALD+ +  + LP                +
Sbjct: 11   PAEFFKRNPELAGFSNPARALYQTVRELVENALDATDVHNILP------------SIKII 58

Query: 371  IGLVDRERVDEALYDDFESSKAREKRLAKEARFQETQAKNAALGKKVKDTPAARGKGRGE 550
            I LVD ++                       +  +   ++  +G      P A GK    
Sbjct: 59   IELVDPQK-----------------------QIYKVNVEDNGIGIPPHIVPNAFGK---- 91

Query: 551  ASFFRVTCKDNGRGMPHEDIPNMFGRVLSGTKYGLRQTRGKFGLGAKMALIWSKMSTGLP 730
                                      VL  +KY LRQTRG +GLG K A+++S+M    P
Sbjct: 92   --------------------------VLYSSKYVLRQTRGMYGLGVKAAVLYSQMYQERP 125

Query: 731  IDIKSSMKGQDYITFCRLDIDIHKNVPHIHLHEKRENNGHWHGAEIQVIIEGNWTTHRSR 910
            +++ +S      I F +L ID+ KN P I       N  +WHG  + + +  +W   + +
Sbjct: 126  VEVVTSPINSKRIYFFKLKIDVVKNEPIILQKTSVVNEKNWHGTSVTLYLYADWQRAKQK 185

Query: 911  ILHYMRQMAVITPYAQFLFRFLSDAAEKNLTIKFARRTDVMPPVPLLTKHHPSAVDLLLI 1090
            I  Y+++  +I+PYA+F F+        N  I + R TD +P  P   K HP  VD+ LI
Sbjct: 186  IYEYVKKTYIISPYAEFFFK-----DPDNNVIYYKRLTDKIPEPPKEVKPHPYGVDIELI 240

Query: 1091 KRLITDTTKP-NLLQFLQHEFVNISKAHADRLIGEMGPDFNAKTTVNSLTSQQLVRIHQL 1267
            K +I    KP  +  FL +EF +I    AD+++       + KTT   LT +++ R+ ++
Sbjct: 241  KFMIVKKDKPVPVRDFLINEFQSIGDVTADKILEMAKLPKDKKTT--ELTDEEISRLVEV 298

Query: 1268 FRQAKFDD---PSGNCLSPAGEYNLRLGIIKELHPDLVATHASSPQVFEGHPFIVEAGVS 1438
             +  KFDD   PS   LS  GE  ++LG+    +P+        P+ ++GHPFIVEAG++
Sbjct: 299  MK--KFDDFRPPSAEALSVIGEDLIKLGLKSIFNPEFAEAITRKPKAYQGHPFIVEAGIA 356

Query: 1439 IGGK-DVKQGLNIFRFANRIPLLFEQGADVITRTALKRINWSIYKINQQQDEIGVFVSIV 1615
             GG         + R+AN+IPL++++ +DVI +   + ++W  Y I ++Q  + V V + 
Sbjct: 357  YGGAIQPSPEPIVLRYANKIPLIYDEKSDVIWKVVTEEMDWKRYGIEEEQPPLVVMVHLC 416

Query: 1616 STKIPFKGTGKEYIGDDITEIADAVKSALKQCCVQLKSKIVKKLQAREQQDRKRNLNKYI 1795
            STK+P++  GKE I  D+ EI   +K AL     +LK  I +K +  E + R     KYI
Sbjct: 417  STKVPYRSAGKESIA-DVEEIEKEIKLALMDVARKLKKYITEKRKEEEAKKRLITYLKYI 475

Query: 1796 PDVARTI--------METLGELADESPPK-----RPRFDKEDEELLEKINSEEVTEM 1927
            P+V+R +         + +G+   +   K       + +  D++L E+I + +V E+
Sbjct: 476  PEVSRGLALFLVGGDKQKIGDAYSDLREKLLKIALNKLEVNDKKLEEEIRNYKVEEL 532

>Q8ZVM0:TOP6B_PYRAE Type 2 DNA topoisomerase 6 subunit B - Pyrobaculum aerophilum|
          Length = 527

 Score =  235 bits (600), Expect = 6e-61
 Identities = 141/416 (33%), Positives = 229/416 (55%), Gaps = 2/416 (0%)
 Frame = +2

Query: 566  VTCKDNGRGMPHEDIPNMFGRVLSGTKYGLRQTRGKFGLGAKMALIWSKMSTGLPIDIKS 745
            V  +DNG G+P  +IPN+FGRV   +KY ++Q RG FGLG KM +++S+ +T  P+ ++S
Sbjct: 69   VYAEDNGIGIPGNEIPNVFGRVFYSSKYKIKQHRGVFGLGLKMVVLYSQSTTNKPVLVRS 128

Query: 746  SMKGQDYITFCRLDIDIHKNVPHIHLHEKRENNGHWHGAEIQVIIEGNWTTHRSRILHYM 925
            +    D I   ++ ID + N P I    +  N   WHG  ++V +EGNW   + RI  Y+
Sbjct: 129  ATLKSDKIYEYQIMIDTNSNSPIILDRREYPNRYKWHGTAVKVYLEGNWLAAKKRIEDYL 188

Query: 926  RQMAVITPYAQFLFRFLSDAAEKNLTIKFARRTDVMPPVPLLTKHHPSAVDLLLIKRLIT 1105
            ++ A+I PYA+ +F+        +L +   RRT  +PP P     HP +VD+  +K++I 
Sbjct: 189  KRTAIIAPYAEIVFK------GPDLELWLKRRTTKLPPAPKEGLPHPKSVDVDTLKQMIQ 242

Query: 1106 DTTKPNLLQFLQHEFVNISKAHADRLIGEMGPDFNAKTTVNSLTSQQLVRIHQLFRQAK- 1282
            ++    LL+FL   F  + +  A   +   G  FN    V +LT ++LV++    +Q + 
Sbjct: 243  ESRGLTLLEFLMENFDAVGEGTAKAFLEWAG--FNPNAKVTALTPEELVKLVDKMKQYEG 300

Query: 1283 FDDPSGNCLSPAGEYNLRLGIIKELHPDLVATHASSPQVFEGHPFIVEAGVSIGGK-DVK 1459
            +  P  + LSPAG   L +G    L  + V      P+ + GHPFIVEA V+ GG+    
Sbjct: 301  WRRPRSDWLSPAGAELLEIGAKAILGAEAVFAITRKPESYGGHPFIVEAAVAWGGQIPPA 360

Query: 1460 QGLNIFRFANRIPLLFEQGADVITRTALKRINWSIYKINQQQDEIGVFVSIVSTKIPFKG 1639
                + R+AN+IPLL+++GADV  R  +   NW  YK+ +    + V + + STKIP+  
Sbjct: 361  DKPLLLRYANKIPLLYDEGADV-ARKVVDEFNWQNYKV-KFPAPLAVIIHVCSTKIPYAS 418

Query: 1640 TGKEYIGDDITEIADAVKSALKQCCVQLKSKIVKKLQAREQQDRKRNLNKYIPDVA 1807
             GKE I  ++ EI   +K AL+    +L+  + +K +  E  ++  +L KY+ ++A
Sbjct: 419  AGKEAIA-EVPEIEKEMKLALRDAAKKLRLYLSRKEKEMEMLNKYISLAKYVEEIA 473



 Score = 50.8 bits (120), Expect = 3e-05
 Identities = 22/42 (52%), Positives = 31/42 (73%)
 Frame = +2

Query: 194 AEFFAENKNIAGFDNPGKSLYTTMRELVENALDSAESISELP 319
           AE+F  N+ +AGF NP ++LY T+REL EN+LD+ E+   LP
Sbjct: 10  AEWFRRNRELAGFHNPTRALYQTIRELTENSLDATETYGILP 51

>O29605:TOP6B_ARCFU Type 2 DNA topoisomerase 6 subunit B - Archaeoglobus fulgidus|
          Length = 602

 Score =  223 bits (569), Expect = 2e-57
 Identities = 131/434 (30%), Positives = 236/434 (54%), Gaps = 11/434 (2%)
 Frame = +2

Query: 560  FRVTCKDNGRGMPHEDIPNMFGRVLSGTKYG-LRQTRGKFGLGAKMALIWSKMSTGLPID 736
            F++  +DNG G+P E IP +FG++L G+++  +RQ+RG+ G+G   A+++++++TG P  
Sbjct: 65   FKIVVEDNGPGIPREQIPKVFGKLLYGSRFHEIRQSRGQQGIGISAAVLYAQLTTGKPAT 124

Query: 737  IKSSMKGQDYITFCRLDIDIHKNVPHIHLHEKRENNGHWH---GAEIQVIIEGNWTTHRS 907
            + S    +D      L I+  KN P I      E    W+   G +I++ + GN+   R 
Sbjct: 125  VISKTPDEDRAKKVVLYINTKKNEPEI----VEEGEEEWYLPSGTKIELEVAGNYVRERK 180

Query: 908  R-ILHYMRQMAVITPYAQFLFRFLSDAAEKNLTI-KFARRTDVMPPVPLLTKHHPSAVDL 1081
            + +  Y+R+ +VI P+A+  F       E + TI +F R TD +P  P   K HP  ++L
Sbjct: 181  QSVYEYLRETSVINPHAKITF------VEPDGTINEFKRVTDDIPQPPKSIKPHPHGIEL 234

Query: 1082 LLIKRLITDTTKPNLLQFLQHEFVNISKAHADRLIGEMGPDFNAKTTVNSLTSQQLVRIH 1261
              +  ++  T    L +FL+ EFV + +  AD ++ + G  F+   T   +      ++ 
Sbjct: 235  GTLMSMLKSTRATTLRRFLKEEFVRVGEKIADDVLRKAG--FSGDETPQEMGRDDAAKLL 292

Query: 1262 QLFRQAKFDDPSGNCLSPAGEYNLRLGIIKELHPDLVATHASSPQVFEGHPFIVEAGVSI 1441
              FRQ  F  P  +CLSP GE  +   ++ E  P+ V      P+V+ GHPF+VE G++ 
Sbjct: 293  NAFRQTDFLPPPTDCLSPIGEAMIAKSLMAEFQPEFVYAVTRKPKVYSGHPFLVEVGLAY 352

Query: 1442 GGKDVKQGLNIFRFANRIPLLFEQGADVITRTALKRINWSIYKINQQQDEIG-----VFV 1606
            GG+   + + + R+AN+IPLL++QG   +T+ A++ +NW  Y + Q + E+      + +
Sbjct: 353  GGEIKSEKVTLLRYANKIPLLYQQGGCALTK-AVESVNWKSYGMVQNRGELPSAPAVILI 411

Query: 1607 SIVSTKIPFKGTGKEYIGDDITEIADAVKSALKQCCVQLKSKIVKKLQAREQQDRKRNLN 1786
             + ST IP+    KE +   I EI D  + AL++   +LK  + +K + ++++ ++  + 
Sbjct: 412  HLASTNIPYTSESKESVA-AIPEIIDETRLALQEVGRRLKEYLERKSRQQKKKKKEEMIG 470

Query: 1787 KYIPDVARTIMETL 1828
            K +P +A+ + E L
Sbjct: 471  KVLPLIAKKVCEIL 484



 Score = 51.6 bits (122), Expect = 2e-05
 Identities = 22/43 (51%), Positives = 31/43 (72%)
 Frame = +2

Query: 194 AEFFAENKNIAGFDNPGKSLYTTMRELVENALDSAESISELPD 322
           AEFF +NK+I G+ NP K++ T ++E V+NALD+ E    LPD
Sbjct: 11  AEFFEKNKHILGYSNPAKAIITVVKEAVDNALDACEEAGILPD 53

>Q8TQF7:TOP6B_METAC Type 2 DNA topoisomerase 6 subunit B - Methanosarcina acetivorans|
          Length = 621

 Score =  181 bits (458), Expect = 2e-44
 Identities = 123/435 (28%), Positives = 221/435 (50%), Gaps = 11/435 (2%)
 Frame = +2

Query: 557  FFRVTCKDNGRGMPHEDIPNMFGRVLSGTKY-GLRQTRGKFGLGAKMALIWSKMSTGLPI 733
            +  V  +DNG G+  E IP +F ++L G+++  L+Q+RG+ G+G   A+++++M+ G   
Sbjct: 73   YVTVIIEDNGPGIVREQIPKVFAKLLYGSRFHALKQSRGQQGIGISAAVLYAQMTAGRHT 132

Query: 734  DIKSSMKGQDYITFCRLDIDIHKNVPHIHLHEKRENNGHW---HGAEIQVIIEGNWTT-H 901
             I S         +  L I+   N P I + E R+    W   HG +I++ ++  +    
Sbjct: 133  KILSKTGSNVPAHYYELMINTSTNEPDILMDEVRD----WFRPHGTQIELEMKAAYVKGR 188

Query: 902  RSRILHYMRQMAVITPYAQFLFRFLSDAAEKNLTIKFARRTDVMPPVPLLTKHHPSAVDL 1081
            R  I  Y++  A++ P+A+       D  E+     F R TD +P        HP  ++L
Sbjct: 189  RQSIYEYLKATAIVNPHARITL-IDPDGNEE----VFERATDKIPDPAEEILPHPEGIEL 243

Query: 1082 LLIKRLITDTTKPNLLQFLQHEFVNISKAHADRLIGEMGPDFNAKTTVNSLTSQQLVRIH 1261
              + +++  T +  L  FL++ F  I    AD +    G D   +   ++L   +  ++ 
Sbjct: 244  GTLMKMLHYTERQKLAPFLRYSFCKIGLLTADEICKAAGLD--PEIDPHALGRHEARKLI 301

Query: 1262 QLFRQAKFDDPSGNCLSPAGEYNLRLGIIKELHPDLVATHASSPQVFEGHPFIVEAGVSI 1441
            + F++ K   P  +CLSP GE  +  G+ KE + D +AT    P V+ G+PF+VE G++ 
Sbjct: 302  EAFQKVKIMSPPTDCLSPIGEELIYRGLEKETNVDFIATSTRKPAVYSGNPFVVEVGLAY 361

Query: 1442 GGKDVK-QGLNIFRFANRIPLLFEQGADVITRTALKRINWSIYKINQQQDEIGV-----F 1603
            GG   K + ++I RFANR+PLL++QG  V T  A++ I W  Y +NQ    + +      
Sbjct: 362  GGNLPKEEKISIMRFANRVPLLYQQGGCVTTH-AVEDIRWKQYGLNQPGGGVPIGPVLLL 420

Query: 1604 VSIVSTKIPFKGTGKEYIGDDITEIADAVKSALKQCCVQLKSKIVKKLQAREQQDRKRNL 1783
            + + S  +PF    K+ I  DI  I + V  A+K+   +LK  + K+   +++++++  +
Sbjct: 421  IHVASINVPFTSESKDAIA-DIPVIKEEVDLAVKEVARKLKHYLSKQSNLKKRREKEIII 479

Query: 1784 NKYIPDVARTIMETL 1828
             K +P +A  +   L
Sbjct: 480  TKVLPKMAVKVANIL 494



 Score = 49.3 bits (116), Expect = 7e-05
 Identities = 22/43 (51%), Positives = 31/43 (72%)
 Frame = +2

Query: 194 AEFFAENKNIAGFDNPGKSLYTTMRELVENALDSAESISELPD 322
           AEFF +N+ I GFD+  +SL TT++E V+N+LD+ E    LPD
Sbjct: 19  AEFFEKNRQILGFDSAPRSLITTVKEAVDNSLDACEEAGILPD 61

>O74020:TOP6B_PYRHO Type 2 DNA topoisomerase 6 subunit B - Pyrococcus horikoshii|
          Length = 564

 Score =  180 bits (457), Expect = 2e-44
 Identities = 143/504 (28%), Positives = 244/504 (48%), Gaps = 49/504 (9%)
 Frame = +2

Query: 560  FRVTCKDNGRGMPHEDIPNMFGRVLSGTKYGLR-QTRGKFGLGAKMALIWSKMSTGLPID 736
            ++V  +DNG G+P E IP++FG++L+GTK     Q+RG+ G+G   A+++++++TG P  
Sbjct: 72   YKVIVEDNGPGIPEEYIPHVFGKMLAGTKAHRNIQSRGQQGIGISGAVMFAQITTGKPTR 131

Query: 737  IKSSMKGQDYITFCRLDIDIHKNVPHIHLHEKRENNGHWHGAEIQVIIEG-NWTTHRSRI 913
            + +S  G+  I    + ID+ KN   I    K  N   W G  I++ ++   +   R  +
Sbjct: 132  VITSTGGE--IVEAWVKIDVQKNEGKIVKKVKHPNPKGWRGTRIEMEVKDVKYVRSRQGV 189

Query: 914  LHYMRQMAVITPYAQFLFRFLSDAAEKNLTIKFARRTDVMPPVPLLTKHHPSAVDLLLIK 1093
              Y++  A+  P+A     ++         + F R ++ +P  P+  K HP  V +  + 
Sbjct: 190  YWYLKLTAIANPHA-----YIELVEPDGKLVVFPRSSEEIPKPPVEMKPHPKGVMVDDVY 244

Query: 1094 RLITDTTKPNLLQFLQHEFVNISKAHADRLIGEMGPDFNAKTTVNS-------------- 1231
             +   + + ++ +FL  EF  IS+   + LI  +      K+  N               
Sbjct: 245  TMAHRSKRSSVKRFLVSEFSRISEKKIEELIKYVAAIRLLKSEQNEEIKEKLREKLINGD 304

Query: 1232 -----------------------------LTSQQLVRIHQLFRQAKFDDPSGNCLSPAGE 1324
                                         LT Q+   I + F+  KF  P  + L P GE
Sbjct: 305  VDSVLRSFGRKWKKEVEKVAKIMEKPPEKLTWQEAEEIVEAFKLMKFLAPPTHGLRPIGE 364

Query: 1325 YNLRLGIIKELHPDLVATHASSPQVFEGH-PFIVEAGVSIGGKDVKQGLNIFRFANRIPL 1501
             N++ G+   L P+ V     SP+V+ G  PF VE G++ GG+    G  I R+ANR+PL
Sbjct: 365  ENIKRGLTGILKPEFVTAVTRSPKVYAGGIPFQVEVGLAYGGQ--ISGSEILRYANRVPL 422

Query: 1502 LFEQGADVITRTALKRINWSIYKINQ-QQDEIGVFVSIVSTKIPFKGTGKEYIGDDITEI 1678
            LF+ G+ VIT +A++ I+W  YKI+      + V V+++S  +P+  TGK+ I  DI EI
Sbjct: 423  LFDAGSCVIT-SAVRSIDWKRYKIDSFDSAPLVVLVNVISVHVPYTSTGKQSIA-DIEEI 480

Query: 1679 ADAVKSALKQCCVQLKSKIVKKLQAREQQDRKRNLNKYIPDVARTIMETLGELADESPPK 1858
             + ++ AL     +L   +  K +   Q  R++ L KY+P++AR++    GE  ++    
Sbjct: 481  YNEIRLALMDAARKLALYLGGKYRRMYQIKRRKTLEKYLPEIARSLHILTGEPEEKI--- 537

Query: 1859 RPRFDK--EDEELLEKINSEEVTE 1924
            R  F K  E +  +E++ S EV E
Sbjct: 538  REYFLKLIESKIEVEEVESVEVEE 561

>Q8PUB8:TOP6B_METMA Type 2 DNA topoisomerase 6 subunit B - Methanosarcina mazei|
            (Methanosarcina frisia)
          Length = 621

 Score =  179 bits (454), Expect = 5e-44
 Identities = 124/435 (28%), Positives = 218/435 (50%), Gaps = 11/435 (2%)
 Frame = +2

Query: 557  FFRVTCKDNGRGMPHEDIPNMFGRVLSGTKY-GLRQTRGKFGLGAKMALIWSKMSTGLPI 733
            +  V  +DNG G+  E IP +F ++L G+++  L+Q+RG+ G+G   A+++++M+ G   
Sbjct: 73   YVTVIIEDNGPGIVREQIPKVFAKLLYGSRFHALKQSRGQQGIGISAAVLYAQMTAGRHT 132

Query: 734  DIKSSMKGQDYITFCRLDIDIHKNVPHIHLHEKRENNGHW---HGAEIQVIIEGNWTT-H 901
             I S         +  L I+   N P I + E R+    W   HG +I++ +   +    
Sbjct: 133  KILSKTSPTAPAHYYELMINTSTNEPDILVDEVRD----WFRPHGTQIELEMRAAYVKGR 188

Query: 902  RSRILHYMRQMAVITPYAQFLFRFLSDAAEKNLTIKFARRTDVMPPVPLLTKHHPSAVDL 1081
            R  I  Y++  A++ P+A+       D  E+     F R TD MP        HP  ++L
Sbjct: 189  RQSIYEYLKATAIVNPHARITL-IDPDGNEE----VFERATDKMPEPAEEILPHPEGIEL 243

Query: 1082 LLIKRLITDTTKPNLLQFLQHEFVNISKAHADRLIGEMGPDFNAKTTVNSLTSQQLVRIH 1261
              + +++  T +  L  FL++ F  I    A+ +    G D   +   ++L   +  ++ 
Sbjct: 244  GTLMKMLHYTERQKLAPFLRYSFCKIGLLTAEEICKAAGLD--PEIDPHALGRHEARKLI 301

Query: 1262 QLFRQAKFDDPSGNCLSPAGEYNLRLGIIKELHPDLVATHASSPQVFEGHPFIVEAGVSI 1441
            + F + K   P  +CLSP GE  +  G+ KE   D +AT    P V+ G+PF+VE G++ 
Sbjct: 302  EAFEKVKIMAPPTDCLSPIGEDLIYRGLEKETTVDFIATSTRKPAVYSGNPFVVEVGMAY 361

Query: 1442 GGKDVK-QGLNIFRFANRIPLLFEQGADVITRTALKRINWSIYKINQQQDEIGV-----F 1603
            GG   K + ++I RFANR+PLL++QG  V T  A++ I W  Y +NQ    I V      
Sbjct: 362  GGNLPKEEKISIMRFANRVPLLYQQGGCVTTH-AVEDIKWKQYGLNQPGGGIPVGPVILL 420

Query: 1604 VSIVSTKIPFKGTGKEYIGDDITEIADAVKSALKQCCVQLKSKIVKKLQAREQQDRKRNL 1783
            + + S  +PF    K+ I  DI  I + +  A+K+   +LK  + K+   +++++++  +
Sbjct: 421  IHVASINVPFTSESKDAIA-DIPVIKEEIDLAIKEVARKLKHYLSKQSNLKKRREKEIII 479

Query: 1784 NKYIPDVARTIMETL 1828
             K +P +A  +   L
Sbjct: 480  TKVLPKLAAKVAHVL 494



 Score = 50.4 bits (119), Expect = 3e-05
 Identities = 23/43 (53%), Positives = 31/43 (72%)
 Frame = +2

Query: 194 AEFFAENKNIAGFDNPGKSLYTTMRELVENALDSAESISELPD 322
           AEFF +N+ I GFD+  +SL TT++E V+NALD+ E    LPD
Sbjct: 19  AEFFEKNRQILGFDSAPRSLITTVKEAVDNALDACEEAGILPD 61

>Q5JH81:TOP6B_PYRKO Type 2 DNA topoisomerase 6 subunit B - Pyrococcus kodakaraensis|
            (Thermococcus kodakaraensis)
          Length = 567

 Score =  177 bits (450), Expect = 1e-43
 Identities = 138/503 (27%), Positives = 238/503 (47%), Gaps = 48/503 (9%)
 Frame = +2

Query: 560  FRVTCKDNGRGMPHEDIPNMFGRVLSGTKYGLR-QTRGKFGLGAKMALIWSKMSTGLPID 736
            ++V  +DNG G+P + I ++FG++L+GTK     Q+RG+ G+G   A++++++++G    
Sbjct: 72   YKVVVEDNGPGIPEKYITHVFGKMLAGTKAHRNIQSRGQQGIGISGAVMFAQITSGKATR 131

Query: 737  IKSSMKGQDYITFCRLDIDIHKNVPHIHLHEKRENNGHWHGAEIQVIIEG-NWTTHRSRI 913
            + +S  G D I    + ID+ KN   I   EK  N   W G  I++ ++   +   +  +
Sbjct: 132  VITST-GNDEIIEAWVKIDVDKNEGKIVKKEKHPNPKGWRGTRIELEVKNVKYMRSKQGV 190

Query: 914  LHYMRQMAVITPYAQFLFRFLSDAAEKNLTIKFARRTDVMPPVPLLTKHHPSAVDLLLIK 1093
              Y++  A+  P+A      +         I F R +D +P  P+  K HP  V    + 
Sbjct: 191  FWYLKLTAIANPHAH-----IELIEPDGKLIVFPRSSDYIPEPPVEMKPHPKGVLTDDVY 245

Query: 1094 RLITDTTKPNLLQFLQHEFVNISKAHADRLIGEMGP------------------------ 1201
            RL   T +  + +FL  EF  IS    D LI  +                          
Sbjct: 246  RLAKKTRRNTVRRFLIGEFSRISDKKVDELIEYIAALRLIKTVEDKKLQEQYYQKLMEGH 305

Query: 1202 ------DFNAKTTV------------NSLTSQQLVRIHQLFRQAKFDDPSGNCLSPAGEY 1327
                   F   T V              LT  +   I + F+  KF  P  + L P GE 
Sbjct: 306  VKAVLRAFKGYTKVVKQVAKMMEKPPEKLTWHEAEEIVEAFKYMKFLAPPTHGLRPIGEE 365

Query: 1328 NLRLGIIKELHPDLVATHASSPQVFEGH-PFIVEAGVSIGGKDVKQGLNIFRFANRIPLL 1504
            N+  G+   L P+ V      P+V+ G  PF VE G++ GG ++  G +++R+ANR+PLL
Sbjct: 366  NIEKGLKGILKPEFVTAVTRPPKVYSGGIPFQVEVGIAYGG-EIPAGFDLYRYANRVPLL 424

Query: 1505 FEQGADVITRTALKRINWSIYKINQ-QQDEIGVFVSIVSTKIPFKGTGKEYIGDDITEIA 1681
            F+ G+ V T+ A + I+W  YKI+   +  + + +++VS  +P+ GTGK+ I   + EI 
Sbjct: 425  FDAGSCVTTQAA-RSIDWKRYKIDDLDRAPLVLMINVVSVHVPYTGTGKQSIA-SVDEIY 482

Query: 1682 DAVKSALKQCCVQLKSKIVKKLQAREQQDRKRNLNKYIPDVARTIMETLGELADESPPKR 1861
            + ++ A+     +L++ +  K +   Q  R++   KY+P++AR +    GE  ++     
Sbjct: 483  NEIRLAIMDAARRLQTYLSGKHRKLAQVKRRKTFEKYVPEIARALSILTGEPEEKIREYF 542

Query: 1862 PRF--DKEDEELLEKINSEEVTE 1924
             RF   K     +E++ +EEV E
Sbjct: 543  IRFIESKFASAEVEEVAAEEVAE 565

>Q9V135:TOP6B_PYRAB Type 2 DNA topoisomerase 6 subunit B - Pyrococcus abyssi|
          Length = 564

 Score =  174 bits (441), Expect = 2e-42
 Identities = 139/503 (27%), Positives = 239/503 (47%), Gaps = 47/503 (9%)
 Frame = +2

Query: 560  FRVTCKDNGRGMPHEDIPNMFGRVLSGTKYGLR-QTRGKFGLGAKMALIWSKMSTGLPID 736
            ++V  +DNG G+P E IP++FG++L+GTK     Q+RG+ G+G   A++++++++G    
Sbjct: 72   YKVIVEDNGPGIPEEYIPHVFGKMLAGTKAHRNIQSRGQQGIGISGAVMFAQITSGKATR 131

Query: 737  IKSSMKGQDYITFCRLDIDIHKNVPHIHLHEKRENNGHWHGAEIQVIIEG-NWTTHRSRI 913
            + +S  G+  I    + ID+ KN   I    K  N   W G  I++ ++   +   +  +
Sbjct: 132  VITSTGGE--IVEAWVKIDVQKNEGKIVKKLKHPNPKGWRGTRIELEVKDVKYVRSKQGV 189

Query: 914  LHYMRQMAVITPYAQFLFRFLSDAAEKNLTIKFARRTDVMPPVPLLTKHHPSAVDLLLIK 1093
              Y++  A+  P+A      +         + F R ++ +P  P+  K HP  V +  + 
Sbjct: 190  YWYLKLTAIANPHAH-----IELVEPDGKLVVFPRSSEDIPEPPVEMKPHPKGVMVDDVY 244

Query: 1094 RLITDTTKPNLLQFLQHEFVNISKAHADRLI----------GEMGPDFNAKT-------- 1219
             +   + + ++ +FL  EF  IS    D LI           E   +   K         
Sbjct: 245  TMAHRSKRSSVRRFLVSEFSRISDKKVDELIKYITALRLIKSETNKEVKEKLYEKLVSGD 304

Query: 1220 -------------------------TVNSLTSQQLVRIHQLFRQAKFDDPSGNCLSPAGE 1324
                                     +   LT  +   I + F+  KF  P  + L P GE
Sbjct: 305  VDSVLRAFGRKWKKELEKVAKIMDKSPEKLTWHEAEEIVEAFKLMKFLAPPTHGLRPIGE 364

Query: 1325 YNLRLGIIKELHPDLVATHASSPQVFEGH-PFIVEAGVSIGGKDVKQGLNIFRFANRIPL 1501
             N++ G+   L P+ V     +P+V+ G  PF VE G++ GG+   QG  I R+ANR+PL
Sbjct: 365  ENIKKGLTSILKPEFVTAVTRAPRVYAGGIPFQVEVGLAYGGQ--IQGSEILRYANRVPL 422

Query: 1502 LFEQGADVITRTALKRINWSIYKINQ-QQDEIGVFVSIVSTKIPFKGTGKEYIGDDITEI 1678
            LF+ G+ VIT +A++ I+W  YKI+      + V V++VS  +P+  TGK+ I  DI EI
Sbjct: 423  LFDAGSCVIT-SAVRSIDWKRYKIDSFDSAPLVVLVNVVSVHVPYTSTGKQSIA-DIDEI 480

Query: 1679 ADAVKSALKQCCVQLKSKIVKKLQAREQQDRKRNLNKYIPDVARTIMETLGELADESPPK 1858
             + ++ AL     +L   +  K +   Q  R++ L KY+P++AR++    GE      P+
Sbjct: 481  HNEIRLALMDAARRLSFYLGGKFRRMYQVKRRKTLEKYLPEIARSLHILTGE------PE 534

Query: 1859 RPRFDKEDEELLEKINSEEVTEM 1927
                +   + +  KI  EEV+E+
Sbjct: 535  EKIKEYFLKLIESKIEVEEVSEV 557

>Q8U0K8:TOP6B_PYRFU Type 2 DNA topoisomerase 6 subunit B - Pyrococcus furiosus|
          Length = 568

 Score =  166 bits (419), Expect = 5e-40
 Identities = 130/473 (27%), Positives = 220/473 (46%), Gaps = 48/473 (10%)
 Frame = +2

Query: 560  FRVTCKDNGRGMPHEDIPNMFGRVLSGTKYGLR-QTRGKFGLGAKMALIWSKMSTGLPID 736
            ++V  +DNG G+P + IP++FG++L+GTK     Q+RG+ G+G   A++++++++G    
Sbjct: 72   YKVIVEDNGPGIPEDYIPHVFGKMLAGTKAHRNIQSRGQQGIGISGAVMFAQITSGKATR 131

Query: 737  IKSSMKGQDYITFCRLDIDIHKNVPHIHLHEKRENNGHWHGAEIQVIIEG-NWTTHRSRI 913
            + +S  G D I    + ID+ KN   I    K  N   W G  I++ ++   +   +  +
Sbjct: 132  VITST-GDDEIVEAWVKIDVQKNEGKIVKKIKHPNPKRWRGTRIELEVKNVKYVRSKQGV 190

Query: 914  LHYMRQMAVITPYAQFLFRFLSDAAEKNLTIKFARRTDVMPPVPLLTKHHPSAVDLLLIK 1093
              Y++  A+  P+A      +         I F R ++ +P  P+  K HP  V    + 
Sbjct: 191  YWYLKLTAIANPHAH-----IELVEPDGKLIVFPRSSEDIPEPPVEMKPHPKGVMTDDVY 245

Query: 1094 RLITDTTKPNLLQFLQHEFVNISKAHAD---------RLIGEMGPDFNAKTTV------- 1225
             +   + +  + +FL  EF  IS    D         RLI     D N K+ +       
Sbjct: 246  TMAHRSKRSTVRRFLVSEFSRISDKKVDELVLYIAALRLINREVTDQNLKSQLIERLANG 305

Query: 1226 ----------------------------NSLTSQQLVRIHQLFRQAKFDDPSGNCLSPAG 1321
                                          LT  +   I + F+  KF  P    L P G
Sbjct: 306  EVEKVLKSFGRKWKKVVEEVEKIMEKPPEKLTWHEAEEIVEAFKLMKFLAPPTYGLRPIG 365

Query: 1322 EYNLRLGIIKELHPDLVATHASSPQVFEGH-PFIVEAGVSIGGKDVKQGLNIFRFANRIP 1498
            E N+  G+   L P+ V      P+V+ G  PF VE G++ GG+       I R+ANR+P
Sbjct: 366  EENIEKGLSSILRPEFVTAVTRPPKVYSGGIPFQVEVGIAYGGEITNS--EILRYANRVP 423

Query: 1499 LLFEQGADVITRTALKRINWSIYKINQ-QQDEIGVFVSIVSTKIPFKGTGKEYIGDDITE 1675
            LLF+ G+ VIT +A++ I+W  Y++       + V V++VS  +P+  TGK+ I   I E
Sbjct: 424  LLFDAGSCVIT-SAVRSIDWRRYRVESFDNAPLVVLVNVVSVHVPYTSTGKQSIA-SIDE 481

Query: 1676 IADAVKSALKQCCVQLKSKIVKKLQAREQQDRKRNLNKYIPDVARTIMETLGE 1834
            I + ++ AL +   +L + +  K +   Q  RK+   KY+P++AR++    GE
Sbjct: 482  IYNEIRLALMEAARRLAAYLGGKYRRLYQIRRKKIFEKYLPEIARSLHILTGE 534

>O27088:TOP6B_METTH Type 2 DNA topoisomerase 6 subunit B - Methanobacterium|
            thermoautotrophicum
          Length = 523

 Score =  155 bits (391), Expect = 1e-36
 Identities = 123/439 (28%), Positives = 211/439 (48%), Gaps = 12/439 (2%)
 Frame = +2

Query: 575  KDNGRGMPHEDIPNMFGRVLSGTKYGLRQTRGKFGLGAKMALIWSKMSTGLPIDIKSSM- 751
            +DNG G+P + IP +F  + +G+K+   Q+RG+ GLG    ++ S+M+TG P+ + S   
Sbjct: 79   QDNGPGIPEKYIPKVFCTMFAGSKFRNIQSRGQQGLGCSGCVLLSQMTTGKPVKVISGTM 138

Query: 752  -KGQDYITFCRLDIDIHKNVPHIHLHEKRENNGHWHGAEIQVIIEGNWTTHRSRILHYMR 928
              G+       L +D+ KN   I   E+ E +G     E+    + +++        Y+R
Sbjct: 139  ENGELKGVKMTLKMDVKKNQGLILEKEEVEVDGTGVCIELH-FKDVSYSLSEQGAYEYIR 197

Query: 929  QMAVITPYAQFLFRFLSDAAEKNLTIKFARRTDVMPPVPLLTKHHP---SAVDLLLIKRL 1099
            +  +  P+A+ +F   +D         F R +DV+PP+P     HP   +A DL+ + + 
Sbjct: 198  RTMIANPHARIVF---NDPTGNRYV--FNRASDVIPPMPKEVLPHPWGVTADDLIFMAK- 251

Query: 1100 ITDTTKPNLLQFLQHEFVNISKAHADRLIGEMGPDFNAKTTVNSLTSQQLVRIHQLFRQA 1279
               T K      L+     +S      L    G D N +     +  ++  +I + F++ 
Sbjct: 252  --HTDKRRFGSMLKSNLSRMSSMKIKELEELTGIDLNKRP--KDMKWEEAEQIVEAFKKM 307

Query: 1280 KFDDPSGNCLSPAGEYNLRLGIIKELHPDLVATHASSPQVFEGH-PFIVEAGVSIGGKDV 1456
            KF  P  + L P GE  +  G+ + L P+  AT    P+ + G   FIVEAG++ GG   
Sbjct: 308  KFMSPPTSGLIPIGEEQIDKGMKEILQPEFTATVTRKPKTYRGGIAFIVEAGIAYGGNSG 367

Query: 1457 K-----QGLNIFRFANRIPLLFEQGADVITRTALKRINWSIYKINQQQD-EIGVFVSIVS 1618
            +     +   I RFANR+PL F+ G+  IT   +K ++W  Y I   ++  I +FV++VS
Sbjct: 368  RLVGDQRKAEIMRFANRVPLTFDAGSCAITE-GVKSLDWKRYGIRDLENAPISIFVNVVS 426

Query: 1619 TKIPFKGTGKEYIGDDITEIADAVKSALKQCCVQLKSKIVKKLQAREQQDRKRNLNKYIP 1798
            T +P+  TGK+ +  +  EI   ++ A      +L   + KK  A+E+  R +    Y+P
Sbjct: 427  TNVPYLSTGKQSVSPE-PEILGEIRQATMIVARKLHKYLRKKKAAKEEAQRAKIFESYVP 485

Query: 1799 DVARTIMETLGELADESPP 1855
                 I++    LA+   P
Sbjct: 486  ----VIIKQAALLAEREEP 500



 Score = 40.0 bits (92), Expect = 0.045
 Identities = 18/44 (40%), Positives = 26/44 (59%)
 Frame = +2

Query: 191 PAEFFAENKNIAGFDNPGKSLYTTMRELVENALDSAESISELPD 322
           P+EFF +NK + GF    +SL     EL+ N+ D+AE    LP+
Sbjct: 18  PSEFFRKNKQMLGFTGKIRSLTIVFHELITNSFDAAEEAGILPE 61

>Q58434:TOP6B_METJA Type 2 DNA topoisomerase 6 subunit B - Methanococcus jannaschii|
          Length = 660

 Score = 97.4 bits (241), Expect = 2e-19
 Identities = 64/214 (29%), Positives = 111/214 (51%), Gaps = 9/214 (4%)
 Frame = +2

Query: 1232 LTSQQLVRIHQLFRQAKFDDPSGNCLSPAGEYNLRLGIIKELHPDLVATHASSPQVFEGH 1411
            LT  +   I    +  +F  P    L P G  N+   + + L PD V     +P+ ++G 
Sbjct: 438  LTWDEAEMIVNCLQSMEFMAPPTTGLRPIGAENIEKSLKELLQPDFVKAITRNPKTYKGG 497

Query: 1412 -PFIVEAGVSIGGKDVKQG-----LNIFRFANRIPLLFEQGADVITRTALKRINWSIYKI 1573
             PF VE  ++ GG   +QG     + I RFAN +PLL++  A  +T+ A+K INW  Y +
Sbjct: 498  IPFAVEVAIAYGGNAGRQGDEGRRMEIMRFANHVPLLYDASACGLTK-AVKSINWKRYGL 556

Query: 1574 NQQQDEIGVFVSIVSTKIPFKGTGKEYIG---DDITEIADAVKSALKQCCVQLKSKIVKK 1744
              +   I VFV+++ST IP+   GK+ +    ++  EI + ++ AL  C  +L+ K + +
Sbjct: 557  RGEDAPITVFVNLISTFIPYTSAGKQAVACSENENEEIYNEIRHALMICGRELE-KYLSR 615

Query: 1745 LQAREQQDRKRNLNKYIPDVARTIMETLGELADE 1846
            ++   ++++KR   KY+   AR   E L  + ++
Sbjct: 616  IRREAEEEKKR---KYVMKYARIFAEALANILNK 646



 Score = 76.3 bits (186), Expect = 6e-13
 Identities = 59/230 (25%), Positives = 109/230 (47%), Gaps = 2/230 (0%)
 Frame = +2

Query: 551  ASFFRVTCKDNGRGMPHEDIPNMFGRVLSGTK-YGLRQTRGKFGLGAKMALIWSKMSTGL 727
            A  ++V  +DNG G+P E IP +FG++L+G+K +   Q+RG+ G+GA   L++S+++TG 
Sbjct: 71   ADHYKVAVEDNGPGIPLEFIPKVFGKMLAGSKMHRFIQSRGQQGIGAAGVLLFSQITTGK 130

Query: 728  PIDIKSSMKGQDYITFCRLDIDIHKNVPHIHLHEKRENNGHWHGAEIQ-VIIEGNWTTHR 904
            P+ I +S  G   I    + +++ KN   I    K+   G W G  ++    E ++    
Sbjct: 131  PLKIITS-TGDGNIYEVEVKMNVEKNEGEI--VSKKVRKGKWRGTRVEGEFKEVSYNRGE 187

Query: 905  SRILHYMRQMAVITPYAQFLFRFLSDAAEKNLTIKFARRTDVMPPVPLLTKHHPSAVDLL 1084
                 Y+R++++ TP+A+ + +      +    + F R  + +P  P   K HP  +   
Sbjct: 188  FGPFEYLRRISLATPHAKIVLK------DPYGEVVFDRVVNELPKKPEEMKPHPYGLTTD 241

Query: 1085 LIKRLITDTTKPNLLQFLQHEFVNISKAHADRLIGEMGPDFNAKTTVNSL 1234
             +  +   T    +   L  E   ++      LI  M  D   K   +S+
Sbjct: 242  ELLYIARKTKSKKVSSMLVSELSRVTTKRIKELINYMLRDLILKKFKDSV 291



 Score = 42.4 bits (98), Expect = 0.009
 Identities = 20/43 (46%), Positives = 28/43 (65%)
 Frame = +2

Query: 194 AEFFAENKNIAGFDNPGKSLYTTMRELVENALDSAESISELPD 322
           AEFF +NK++ G+    +SL T + ELV N+LD+ E    LPD
Sbjct: 19  AEFFRKNKHMLGYSGKIRSLTTIIHELVTNSLDACEEAGILPD 61

>Q9HR31:TOP6B_HALSA Type 2 DNA topoisomerase 6 subunit B - Halobacterium salinarium|
            (Halobacterium halobium)
          Length = 804

 Score = 96.3 bits (238), Expect = 5e-19
 Identities = 62/189 (32%), Positives = 97/189 (51%), Gaps = 7/189 (3%)
 Frame = +2

Query: 1292 PSGNCLSPAGEYNLRLGIIKELHPDLVATHASSPQVFEGHPFIVEAGVSIGGK-DVKQGL 1468
            P  +CLSP     L  G+  E   D  A       V  G PFIVEAG++ GG  D + G+
Sbjct: 505  PPTSCLSPIEADQLEAGLRTEFDADFYAAATRDADVHGGDPFIVEAGIAYGGDIDSEGGV 564

Query: 1469 NIFRFANRIPLLFEQGADVITRTALKRINWSIYKINQ------QQDEIGVFVSIVSTKIP 1630
             + RFANR+PL++++GA   T   L  I W  Y ++Q       Q    + V + ST +P
Sbjct: 565  QLMRFANRVPLVYQRGA-CATTDVLGDIGWRNYNLSQPGGSGLPQGPAVIMVHVASTNVP 623

Query: 1631 FKGTGKEYIGDDITEIADAVKSALKQCCVQLKSKIVKKLQAREQQDRKRNLNKYIPDVAR 1810
            F    K+ I  ++ EI   ++ A+++   +LKS + K+   R++Q ++      I D+  
Sbjct: 624  FTSESKDAIA-NVPEIEAEIELAVREAARELKSFLQKRQSMRKRQQKQ----DVIMDILP 678

Query: 1811 TIMETLGEL 1837
            T+ E +GEL
Sbjct: 679  TMAEKVGEL 687



 Score = 83.2 bits (204), Expect = 5e-15
 Identities = 56/220 (25%), Positives = 110/220 (50%), Gaps = 10/220 (4%)
 Frame = +2

Query: 557  FFRVTCKDNGRGMPHEDIPNMFGRVLSGTKYGLR-QTRGKFGLGAKMALIWSKMSTGLPI 733
            ++ +  +DNG G+ +  IP +FG++L G+++  R Q+RG+ G+G   A+++S++++G P+
Sbjct: 82   YYTLIVEDNGPGITNAQIPKIFGKLLYGSRFHAREQSRGQQGIGISAAVLYSQLTSGKPV 141

Query: 734  DIKSSMKGQDYITFCRLDIDIHKNVPHI----HLHEKRENNGHWHGAEIQVIIEGNWTTH 901
             I+S  +  +      L ID   N P I     +   + +    HG  I++ ++ N    
Sbjct: 142  RIESRTQDSETANVYELIIDTDTNEPEISAETEVSAAKSDLRGTHGTRIEMALDANMRA- 200

Query: 902  RSRILHYMRQMAVITPYAQFLFR-----FLSDAAEKNLTIKFARRTDVMPPVPLLTKHHP 1066
            R ++  Y++  AV+ P+A+   +       S+ AE+         TD + P       HP
Sbjct: 201  RGQLHDYIKHTAVVNPHARIELQEPGGELKSERAEE---ASLPAETDEILP-------HP 250

Query: 1067 SAVDLLLIKRLITDTTKPNLLQFLQHEFVNISKAHADRLI 1186
              V+L  + +++ +T   ++  FLQ EF  +    A  +I
Sbjct: 251  HGVELGTLIKMLAETDSHSVSGFLQSEFTRVGSKTATGII 290



 Score = 47.8 bits (112), Expect = 2e-04
 Identities = 21/43 (48%), Positives = 30/43 (69%)
 Frame = +2

Query: 194 AEFFAENKNIAGFDNPGKSLYTTMRELVENALDSAESISELPD 322
           AEFF +NK++ GFD+  + L T ++E V+NALD+ E    LPD
Sbjct: 29  AEFFEKNKHMLGFDSGARGLVTAVKEAVDNALDATEEAGILPD 71

>P35164:RESE_BACSU Sensor protein resE - Bacillus subtilis|
          Length = 589

 Score = 37.0 bits (84), Expect = 0.38
 Identities = 17/47 (36%), Positives = 28/47 (59%)
 Frame = +2

Query: 563 RVTCKDNGRGMPHEDIPNMFGRVLSGTKYGLRQTRGKFGLGAKMALI 703
           ++  KD+G G+P ED+P +F R     K    +TRG+ G G  +A++
Sbjct: 515 KIDIKDSGSGIPEEDLPFIFERFYKADK---ARTRGRAGTGLGLAIV 558

>Q9CMV2:Y703_PASMU UPF0208 membrane protein PM0703 - Pasteurella multocida|
          Length = 147

 Score = 36.2 bits (82), Expect = 0.65
 Identities = 18/52 (34%), Positives = 33/52 (63%)
 Frame = -3

Query: 1743 FFTIFDFSWTQHCLRADLTASAISVISSPIYSFPVPLKGIFVLTMLTKTPIS 1588
            F  +F  +W Q   ++D++A AI+V S+ I +  +PL+G++ L   + TP+S
Sbjct: 45   FLAVFAITWQQVYAKSDISALAIAVFSA-IVALLIPLQGLYWLGKRSITPLS 95

>Q8BK62:OLFL3_MOUSE Olfactomedin-like protein 3 precursor - Mus musculus (Mouse)|
          Length = 406

 Score = 35.8 bits (81), Expect = 0.85
 Identities = 25/77 (32%), Positives = 38/77 (49%), Gaps = 3/77 (3%)
 Frame = +2

Query: 350 KSKFNTMIGLVDRERVDEALYDDFESSKAREKRLAKEARFQETQAKN---AALGKKVKDT 520
           K+K   ++ + ++ER  E L  + +S   R  RL +E  + ETQ        L +KV   
Sbjct: 59  KNKMLPLLEVAEKER--ETLRTEADSISGRVDRLEREVDYLETQNPALPCVELDEKVTGG 116

Query: 521 PAARGKGRGEASFFRVT 571
           P A+GKGR    +  VT
Sbjct: 117 PGAKGKGRRNEKYDMVT 133

>Q14185:DOCK1_HUMAN Dedicator of cytokinesis protein 1 - Homo sapiens (Human)|
          Length = 1865

 Score = 35.8 bits (81), Expect = 0.85
 Identities = 26/110 (23%), Positives = 50/110 (45%), Gaps = 11/110 (10%)
 Frame = +2

Query: 1577 QQQDEIGVFVSIVSTKIPFKGTGKEYIGDDITEIADAVKSALKQCCVQLKSKIVKKLQAR 1756
            +  ++I     +++ +IPF   G    GD +TE        ++ C  QLK K+ K+   R
Sbjct: 1556 EAHEKIEKLKDLIAWQIPFLAEGIRIHGDKVTEALRPFHERMEACFKQLKEKVEKEYGVR 1615

Query: 1757 --------EQQDRKRNLNK--YIPDVARTI-METLGELADESPPKRPRFD 1873
                     +  R R++ +   +P  +R + + ++  L+ +S P RP  D
Sbjct: 1616 IMPSSLDDRRGSRPRSMVRSFTMPSSSRPLSVASVSSLSSDSTPSRPGSD 1665

>Q6DRN3:NOC3L_DANRE Nucleolar complex protein 3 homolog - Danio rerio (Zebrafish)|
            (Brachydanio rerio)
          Length = 800

 Score = 35.0 bits (79), Expect = 1.5
 Identities = 23/83 (27%), Positives = 45/83 (54%), Gaps = 5/83 (6%)
 Frame = +2

Query: 1691 KSALKQCCVQLKSKIVKKL-----QAREQQDRKRNLNKYIPDVARTIMETLGELADESPP 1855
            +  LK   ++L++K+  +       A++Q+  +R L+K I DV+   ++ L     E   
Sbjct: 16   RKLLKTSNLKLENKLKNRQFKQQSSAKKQRKEQRKLHKAISDVSHQTLKPL-----ERYK 70

Query: 1856 KRPRFDKEDEELLEKINSEEVTE 1924
            KRP  ++E+EE LE + ++ + E
Sbjct: 71   KRPEDEEEEEEFLESLPTDMMDE 93

>Q9NRN5:OLFL3_HUMAN Olfactomedin-like protein 3 precursor - Homo sapiens (Human)|
          Length = 406

 Score = 34.7 bits (78), Expect = 1.9
 Identities = 26/79 (32%), Positives = 40/79 (50%), Gaps = 5/79 (6%)
 Frame = +2

Query: 350 KSKFNTMIGLVDRERVDEALYDDFESSKAREKRLAKEARFQETQAKNAAL-----GKKVK 514
           K+K   ++ + ++ER  EAL  + ++   R  RL +E  + ETQ  N AL      +KV 
Sbjct: 59  KNKMLPLLEVAEKER--EALRTEADTISGRVDRLEREVDYLETQ--NPALPCVEFDEKVT 114

Query: 515 DTPAARGKGRGEASFFRVT 571
             P  +GKGR    +  VT
Sbjct: 115 GGPGTKGKGRRNEKYDMVT 133

>Q8BGX7:K0146_MOUSE Uncharacterized protein KIAA0146 - Mus musculus (Mouse)|
          Length = 933

 Score = 34.7 bits (78), Expect = 1.9
 Identities = 23/84 (27%), Positives = 45/84 (53%), Gaps = 1/84 (1%)
 Frame = +2

Query: 1838 ADESPPKRPRFDKEDEELLEKINSEEVTEMTFRDCLTQHVEQVDYEMALEYAMQSGVSEE 2017
            +D+  P  P   ++D+  L+  + +    +T  D L +  E +  E+ LEY+  S   E+
Sbjct: 156  SDKEDPGGPSECEDDKGTLDISDCDSCASLTSDDRLCEPSEPISTEI-LEYSSDSEKEED 214

Query: 2018 PREAIYLNSLEGSYKF-VDFQSPA 2086
            P  +++++S E  +K+  DF+S A
Sbjct: 215  PEHSLFIDS-ESPHKYQADFKSDA 237

>P21053:VF12_VACCC Protein F12 - Vaccinia virus (strain Copenhagen) (VACV)|
          Length = 635

 Score = 34.3 bits (77), Expect = 2.5
 Identities = 23/87 (26%), Positives = 44/87 (50%), Gaps = 5/87 (5%)
 Frame = +2

Query: 575 KDNGRGM--PHEDIPNMFGRVLSGTKYGL--RQTRGKFGLGAKMALIWSKM-STGLPIDI 739
           ++ G GM  P  DIP++F        Y +   Q   K+ + + + +I SK    G P  +
Sbjct: 414 ENTGMGMYYPTNDIPSLFIESSICLDYIIVNNQESNKYRIKSVLDIISSKQYPAGRPNYV 473

Query: 740 KSSMKGQDYITFCRLDIDIHKNVPHIH 820
           K+  KG+ YI  C++ +  + ++P ++
Sbjct: 474 KNGTKGKLYIALCKVTVPTNDHIPVVY 500

>Q640L5:CCD18_MOUSE Coiled-coil domain-containing protein 18 - Mus musculus (Mouse)|
          Length = 1455

 Score = 33.9 bits (76), Expect = 3.2
 Identities = 52/241 (21%), Positives = 100/241 (41%), Gaps = 17/241 (7%)
 Frame = +2

Query: 1349 KELHPDLVATHASSPQVFEGHPFIVEAGVSIGGKDVKQGLNIFRFANRIPLLFEQGADV- 1525
            KE H + +A    + QV E H   +EA +    K +   ++  + A +I ++  Q     
Sbjct: 1182 KEAHGNRLAEELGASQVREAH---LEARMQAEIKKLSSEVDSLKEAYQIEMISHQENHAK 1238

Query: 1526 ------ITRTALKRINWSIYKINQQQDEIGVFVSIVSTKIPFKGTGKEYIGDDITEIADA 1687
                    +T+++++N  + K  Q+ +E    VS +  ++            D  E+ +A
Sbjct: 1239 WKLSAESQKTSVQQLNEQLEKAKQELEEAQDTVSNLHQQV-----------QDRNEVIEA 1287

Query: 1688 VKSALKQCCVQLKSKIVKKLQAREQQDRKRNLNKYIPDVARTIMETLGELADESPPKRPR 1867
               AL      +K   + +LQA+     K    KY+P    T+ E + +       + P 
Sbjct: 1288 ANEALL-----IKESELTRLQAKISGHEKTEDTKYLPAPFTTLTEIIPD------SQHPN 1336

Query: 1868 FDKEDEELLEKI----NSEEVTEMTFR----DCLTQHVEQVDYEMALEY--AMQSGVSEE 2017
            F K  +  L K      S   ++++F+    D L++ + Q   +M  E   A++SG  + 
Sbjct: 1337 FAKHSQISLFKCRKLRRSISASDLSFKSHGNDDLSEELLQDLKKMQFEQTSAIESGHKDL 1396

Query: 2018 P 2020
            P
Sbjct: 1397 P 1397

>Q5DRB2:PCDG8_PANTR Protocadherin gamma A8 precursor - Pan troglodytes (Chimpanzee)|
          Length = 932

 Score = 33.5 bits (75), Expect = 4.2
 Identities = 24/89 (26%), Positives = 41/89 (46%), Gaps = 5/89 (5%)
 Frame = +2

Query: 1346 IKELHPDLVATHASSPQVFEGHPFIVEAGVSIGGKDV-KQGLNIFRFANRIPLLFEQGAD 1522
            + +  P+++ T   SP +    P  V A +S+  +D  K G  +    + +P   E+  D
Sbjct: 340  VNDNRPEVIITSLFSPVLENSLPGTVIAFLSVHDQDSGKNGQVVCHTRDNLPFKLEKSID 399

Query: 1523 ----VITRTALKRINWSIYKINQQQDEIG 1597
                ++TR  L R N SIY I     ++G
Sbjct: 400  NYYRLVTRKYLDRENVSIYNITVMASDLG 428

>Q8BUR4:DOCK1_MOUSE Dedicator of cytokinesis protein 1 - Mus musculus (Mouse)|
          Length = 1865

 Score = 33.5 bits (75), Expect = 4.2
 Identities = 24/99 (24%), Positives = 45/99 (45%), Gaps = 11/99 (11%)
 Frame = +2

Query: 1610 IVSTKIPFKGTGKEYIGDDITEIADAVKSALKQCCVQLKSKIVKKLQAR--------EQQ 1765
            +++ +IPF   G    GD +TE        ++ C  QLK K+ K+   R         + 
Sbjct: 1567 LIAWQIPFLAEGIRIHGDKVTEALRPFHERMEACFKQLKEKVEKQYGVRTMPSGLDDRRG 1626

Query: 1766 DRKRNLNK--YIPDVARTI-METLGELADESPPKRPRFD 1873
             R R++ +   +P  +R + + ++   + +S P RP  D
Sbjct: 1627 SRPRSMVRSFTMPSSSRPLSVASVSSFSSDSTPSRPGSD 1665

>Q6P5H2:NEST_MOUSE Nestin - Mus musculus (Mouse)|
          Length = 1864

 Score = 33.1 bits (74), Expect = 5.5
 Identities = 27/157 (17%), Positives = 74/157 (47%)
 Frame = +2

Query: 1457 KQGLNIFRFANRIPLLFEQGADVITRTALKRINWSIYKINQQQDEIGVFVSIVSTKIPFK 1636
            +Q   +    N+ PL FE+  D +    +++ +    K  +++D+               
Sbjct: 781  QQAFRLLEKENQEPLRFEEAEDQVLERLVEKESQESLKSPEEEDQ--------------- 825

Query: 1637 GTGKEYIGDDITEIADAVKSALKQCCVQLKSKIVKKLQAREQQDRKRNLNKYIPDVARTI 1816
             TGK    ++   +    ++  ++  V L+SK  + L++ E ++ ++ + K +  V++  
Sbjct: 826  RTGKPLEKENQESLRSLDEN--QETIVLLESKNQRPLRSLEVEEEEQRIVKPLEKVSQVS 883

Query: 1817 METLGELADESPPKRPRFDKEDEELLEKINSEEVTEM 1927
            +E+L    ++   + PR+ +ED+ +++ +  ++  E+
Sbjct: 884  LESL----EKENVQSPRYLEEDDHMIKSLLEDKTHEI 916

>Q14789:GOGB1_HUMAN Golgin subfamily B member 1 - Homo sapiens (Human)|
          Length = 3259

 Score = 33.1 bits (74), Expect = 5.5
 Identities = 42/175 (24%), Positives = 76/175 (43%), Gaps = 12/175 (6%)
 Frame = +2

Query: 1544 KRINWSIYKINQQQDEIGVFVSIVSTKIPFKGTGKEYIGDDITEIADAVKSALKQCCVQL 1723
            +RI   +  + Q++ E+  +  + ST+   K T K+    +  +  + +K  +++     
Sbjct: 1630 ERIQHVVEAVRQEKQEL--YGKLRSTEANKKETEKQL--QEAEQEMEEMKEKMRKFA--- 1682

Query: 1724 KSKIVKKLQAREQQDRKRNLNKYIPDVARTIMETLGELADESPPKRPRFDKEDEELLEKI 1903
            KSK  K L+  E+ DR R       D A+  METL         +  R   E E L +K 
Sbjct: 1683 KSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKF 1742

Query: 1904 NSEEVTEMTFRDCLTQHVE------------QVDYEMALEYAMQSGVSEEPREAI 2032
             S     M+ +D L++ V+            Q + E   ++  Q+ V+EE  ++I
Sbjct: 1743 QS----LMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSI 1793

>P33871:VF12_VARV Protein F12 - Variola virus|
          Length = 635

 Score = 32.7 bits (73), Expect = 7.2
 Identities = 23/87 (26%), Positives = 43/87 (49%), Gaps = 5/87 (5%)
 Frame = +2

Query: 575 KDNGRGM--PHEDIPNMFGRVLSGTKYGL--RQTRGKFGLGAKMALIWSKM-STGLPIDI 739
           K+ G GM  P  DI ++F        Y +   Q   K+ + + + +I SK    G P  +
Sbjct: 414 KNTGMGMYYPTNDISSLFIESSICLDYIIVNNQKSNKYRIKSVLDIISSKQYPAGRPNYV 473

Query: 740 KSSMKGQDYITFCRLDIDIHKNVPHIH 820
           K+  KG+ YI  C++ +  + ++P ++
Sbjct: 474 KNGTKGKLYIALCKVTVPTNDHIPVVY 500

>Q9XH58:ETR1_PELHO Ethylene receptor 1 - Pelargonium hortorum (Common geranium)|
          Length = 740

 Score = 32.7 bits (73), Expect = 7.2
 Identities = 25/97 (25%), Positives = 42/97 (43%), Gaps = 1/97 (1%)
 Frame = +2

Query: 557 FFRVTCKDNGRGMPHEDIPNMFGRVLSGTKYGLRQTRGKFGLGAKMALIWSKMSTG-LPI 733
           + RV  KD+G G+  +D+P +F +         + + G  GLG  ++  +  +  G + I
Sbjct: 510 YMRVQVKDSGSGINPQDMPKLFTKFAQSQPVATKNSGGS-GLGLAISKRFVNLMDGHIWI 568

Query: 734 DIKSSMKGQDYITFCRLDIDIHKNVPHIHLHEKRENN 844
           D +   KG       +L I    N P + L  K   N
Sbjct: 569 DSEGPSKGCTVTFVVKLGIPEGSNEPKLPLMPKVSAN 605

>Q92608:DOCK2_HUMAN Dedicator of cytokinesis protein 2 - Homo sapiens (Human)|
          Length = 1830

 Score = 32.7 bits (73), Expect = 7.2
 Identities = 25/112 (22%), Positives = 50/112 (44%), Gaps = 7/112 (6%)
 Frame = +2

Query: 1577 QQQDEIGVFVSIVSTKIPFKGTGKEYIGDDITEIADAVKSALKQCCVQLKSKIVKKLQAR 1756
            + QD++     +++ +IPF G G +     +++        +++C   LK K+ K+   R
Sbjct: 1561 EDQDKLTHLKDLIAWQIPFLGAGIKIHEKRVSDNLRPFHDRMEECFKNLKMKVEKEYGVR 1620

Query: 1757 EQQD-------RKRNLNKYIPDVARTIMETLGELADESPPKRPRFDKEDEEL 1891
            E  D       R R++ +    +  +I+      +D S P +P  +  D EL
Sbjct: 1621 EMPDFDDRRVGRPRSMLRSYRQM--SIISLASMNSDCSTPSKPTSESFDLEL 1670


  Database: uniprot_sprot.fasta.out
    Posted date:  Jul 19, 2007  5:58 PM
  Number of letters in database: 100,686,439
  Number of sequences in database:  274,295
  
Lambda     K      H
   0.318    0.134    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 274295
Number of Hits to DB: 406,509,365
Number of extensions: 8922495
Number of successful extensions: 25466
Number of sequences better than 10.0: 31
Number of HSP's gapped: 25384
Number of HSP's successfully gapped: 48
Length of query: 809
Length of database: 100,686,439
Length adjustment: 122
Effective length of query: 687
Effective length of database: 67,222,449
Effective search space: 46181822463
Effective search space used: 46181822463
Neighboring words threshold: 12
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)