Clone Information

BLAST Search Result

Clone Name	FLbaf15g10
Clone Library Name	barley_pub

No.	Definition	Score (bits)	E Value
1	Q7Z3V4:UBE3B_HUMAN Ubiquitin-protein ligase E3B - Homo sapiens (...	381	e-104
2	Q08CZ0:UBE3B_XENTR Ubiquitin-protein ligase E3B - Xenopus tropic...	375	e-103
3	Q9ES34:UBE3B_MOUSE Ubiquitin-protein ligase E3B - Mus musculus (...	371	e-101
4	Q80U95:UBE3C_MOUSE Ubiquitin-protein ligase E3C - Mus musculus (...	359	4e-98
5	Q15386:UBE3C_HUMAN Ubiquitin-protein ligase E3C - Homo sapiens (...	359	5e-98
6	P53119:HUL5_YEAST Probable E3 ubiquitin-protein ligase HUL5 - Sa...	259	4e-68
7	Q8GY23:UPL1_ARATH E3 ubiquitin-protein ligase UPL1 - Arabidopsis...	233	3e-60
8	Q8H0T4:UPL2_ARATH E3 ubiquitin-protein ligase UPL2 - Arabidopsis...	228	1e-58
9	Q9VVI3:NEDD4_DROME E3 ubiquitin-protein ligase Nedd-4 - Drosophi...	225	1e-57
10	P46935:NEDD4_MOUSE E3 ubiquitin-protein ligase NEDD4 - Mus muscu...	214	2e-54
11	P46934:NEDD4_HUMAN E3 ubiquitin-protein ligase NEDD4 - Homo sapi...	214	3e-54
12	Q62940:NEDD4_RAT E3 ubiquitin-protein ligase NEDD4 - Rattus norv...	213	4e-54
13	Q8CFI0:NED4L_MOUSE E3 ubiquitin-protein ligase NEDD4-like protei...	209	6e-53
14	Q96PU5:NED4L_HUMAN E3 ubiquitin-protein ligase NEDD4-like protei...	209	6e-53
15	Q5RBF2:NED4L_PONPY E3 ubiquitin-protein ligase NEDD4-like protei...	209	8e-53
16	Q9P4Z1:TOM1_NEUCR E3 ubiquitin-protein ligase TOM1-like protein ...	204	2e-51
17	O13834:PTR1_SCHPO E3 ubiquitin-protein ligase ptr1 - Schizosacch...	202	1e-50
18	Q92462:PUB1_SCHPO E3 ubiquitin-protein ligase pub1 - Schizosacch...	201	2e-50
19	Q7TMY8:HUWE1_MOUSE E3 ubiquitin-protein ligase HUWE1 - Mus muscu...	201	2e-50
20	Q7Z6Z7:HUWE1_HUMAN E3 ubiquitin-protein ligase HUWE1 - Homo sapi...	201	2e-50
21	Q756G2:TOM1_ASHGO Probable E3 ubiquitin-protein ligase TOM1 - As...	200	3e-50
22	O00308:WWP2_HUMAN NEDD4-like E3 ubiquitin-protein ligase WWP2 - ...	194	2e-48
23	Q9DBH0:WWP2_MOUSE NEDD4-like E3 ubiquitin-protein ligase WWP2 - ...	194	3e-48
24	Q28BK1:HACE1_XENTR E3 ubiquitin-protein ligase HACE1 - Xenopus t...	192	6e-48
25	Q6DCL5:HACE1_XENLA E3 ubiquitin-protein ligase HACE1 - Xenopus l...	192	6e-48
26	Q96J02:ITCH_HUMAN E3 ubiquitin-protein ligase Itchy homolog - Ho...	192	8e-48
27	Q9UTG2:PUB2_SCHPO E3 ubiquitin-protein ligase pub2 - Schizosacch...	190	3e-47
28	Q8C863:ITCH_MOUSE E3 ubiquitin-protein ligase Itchy - Mus muscul...	189	5e-47
29	Q03280:TOM1_YEAST E3 ubiquitin-protein ligase TOM1 - Saccharomyc...	188	1e-46
30	Q9PUN2:SMUF1_XENLA E3 ubiquitin-protein ligase SMURF1 - Xenopus ...	188	1e-46
31	Q9HAU4:SMUF2_HUMAN E3 ubiquitin-protein ligase SMURF2 - Homo sap...	187	2e-46
32	Q9V853:SMUF1_DROME E3 ubiquitin-protein ligase Smurf1 - Drosophi...	187	2e-46
33	O14326:PUB3_SCHPO E3 ubiquitin-protein ligase pub3 - Schizosacch...	187	2e-46
34	Q9CUN6:SMUF1_MOUSE E3 ubiquitin-protein ligase SMURF1 - Mus musc...	187	3e-46
35	Q9HCE7:SMUF1_HUMAN E3 ubiquitin-protein ligase SMURF1 - Homo sap...	187	3e-46
36	P51593:HUWE1_RAT E3 ubiquitin-protein ligase HUWE1 - Rattus norv...	187	3e-46
37	Q8BZZ3:WWP1_MOUSE NEDD4-like E3 ubiquitin-protein ligase WWP1 - ...	185	1e-45
38	Q9H0M0:WWP1_HUMAN NEDD4-like E3 ubiquitin-protein ligase WWP1 - ...	185	1e-45
39	Q9Y0H4:SUDX_DROME E3 ubiquitin-protein ligase suppressor of delt...	183	4e-45
40	Q6I6G8:HECW2_MOUSE E3 ubiquitin-protein ligase HECW2 - Mus muscu...	182	6e-45
41	Q9P2P5:HECW2_HUMAN E3 ubiquitin-protein ligase HECW2 - Homo sapi...	182	8e-45
42	Q3U0D9:HACE1_MOUSE E3 ubiquitin-protein ligase HACE1 - Mus muscu...	181	2e-44
43	Q8IYU2:HACE1_HUMAN E3 ubiquitin-protein ligase HACE1 - Homo sapi...	181	2e-44
44	Q05086:UBE3A_HUMAN Ubiquitin-protein ligase E3A - Homo sapiens (...	177	3e-43
45	P39940:RSP5_YEAST E3 ubiquitin-protein ligase RSP5 - Saccharomyc...	177	4e-43
46	Q76N89:HECW1_HUMAN E3 ubiquitin-protein ligase HECW1 - Homo sapi...	176	5e-43
47	Q8K4P8:HECW1_MOUSE E3 ubiquitin-protein ligase HECW1 - Mus muscu...	175	1e-42
48	Q5GLZ8:HERC4_HUMAN Probable E3 ubiquitin-protein ligase HERC4 - ...	169	1e-40
49	O08759:UBE3A_MOUSE Ubiquitin-protein ligase E3A - Mus musculus (...	166	6e-40
50	Q6PAV2:HERC4_MOUSE Probable E3 ubiquitin-protein ligase HERC4 - ...	165	1e-39
51	Q5PQN1:HERC4_RAT Probable E3 ubiquitin-protein ligase HERC4 - Ra...	165	1e-39
52	Q15034:HERC3_HUMAN Probable E3 ubiquitin-protein ligase HERC3 - ...	154	2e-36
53	Q757T0:HUL4_ASHGO Probable E3 ubiquitin-protein ligase HUL4 - As...	150	4e-35
54	Q5RD78:HECD2_PONPY Probable E3 ubiquitin-protein ligase HECTD2 -...	147	2e-34
55	Q8CDU6:HECD2_MOUSE Probable E3 ubiquitin-protein ligase HECTD2 -...	147	3e-34
56	Q5U5R9:HECD2_HUMAN Probable E3 ubiquitin-protein ligase HECTD2 -...	146	5e-34
57	Q9UII4:HERC5_HUMAN Probable E3 ubiquitin-protein ligase HERC5 - ...	145	9e-34
58	Q8CHG5:K0317_MOUSE Protein KIAA0317 - Mus musculus (Mouse)	142	1e-32
59	O15033:K0317_HUMAN Protein KIAA0317 - Homo sapiens (Human)	142	1e-32
60	P40985:HUL4_YEAST Probable E3 ubiquitin-protein ligase HUL4 - Sa...	136	7e-31
61	Q8IVU3:HERC6_HUMAN Probable E3 ubiquitin-protein ligase HERC6 - ...	135	2e-30
62	Q14669:TRIPC_HUMAN Probable E3 ubiquitin-protein ligase TRIP12 -...	117	3e-25
63	P33202:UFD4_YEAST Ubiquitin fusion degradation protein 4 - Sacch...	109	9e-23
64	Q4U2R1:HERC2_MOUSE Probable E3 ubiquitin-protein ligase HERC2 - ...	96	1e-18
65	O95714:HERC2_HUMAN Probable E3 ubiquitin-protein ligase HERC2 - ...	96	1e-18
66	Q10435:YDE1_SCHPO Probable ubiquitin fusion degradation protein ...	94	5e-18
67	Q3U487:HECD3_MOUSE Probable E3 ubiquitin-protein ligase HECTD3 -...	91	4e-17
68	Q5T447:HECD3_HUMAN Probable E3 ubiquitin-protein ligase HECTD3 -...	89	1e-16
69	Q9ULT8:HECD1_HUMAN E3 ubiquitin-protein ligase HECTD1 - Homo sap...	85	2e-15
70	Q9VR91:HERC2_DROME Probable E3 ubiquitin-protein ligase HERC2 - ...	79	1e-13
71	P51592:HYD_DROME E3 ubiquitin-protein ligase hyd - Drosophila me...	72	2e-11
72	Q80TP3:EDD1_MOUSE E3 ubiquitin-protein ligase EDD1 - Mus musculu...	71	3e-11
73	O95071:EDD1_HUMAN E3 ubiquitin-protein ligase EDD1 - Homo sapien...	71	3e-11
74	Q62671:EDD1_RAT E3 ubiquitin-protein ligase EDD1 - Rattus norveg...	70	5e-11
75	Q9FFQ1:RH31_ARATH DEAD-box ATP-dependent RNA helicase 31 - Arabi...	37	0.75
76	Q80X72:LRC15_MOUSE Leucine-rich repeat-containing protein 15 pre...	36	0.98
77	Q09573:KCC2_CAEEL Sodium/chloride cotransporter type 2 - Caenorh...	34	3.7
78	P29551:EF3_PNECA Elongation factor 3 - Pneumocystis carinii	34	3.7
79	Q5F4A1:K1333_CHICK Probable E3 ubiquitin-protein ligase-like pro...	33	6.4
80	O67137:GYRB_AQUAE DNA gyrase subunit B - Aquifex aeolicus	33	8.3
81	P25997:EF3_CANAL Elongation factor 3 - Candida albicans (Yeast)	33	8.3

>Q7Z3V4:UBE3B_HUMAN Ubiquitin-protein ligase E3B - Homo sapiens (Human)|
          Length = 1068
 Score =  381 bits (978), Expect = e-104
 Identities = 236/641 (36%), Positives = 348/641 (54%), Gaps = 41/641 (6%)
 Frame = +1

Query: 1333 AEVEAVGSICAFLHVMFSTLP---LDVTMTALAYRTDIVPALWNFIKRCHENQRWPYFSK 1503
            AEV+ V +IC       +TL    L + +T L Y  D++P LW FI     +     F +
Sbjct: 455  AEVQKVCNICVLYQTSLTTLTQIRLQI-LTGLTYLDDLLPKLWAFICELGPHGGLKLFLE 513

Query: 1504 YISPLPVDAPGWLLPVSVFCPIYKYMLKIVDNEEFYEQEKPLSLKDLKALVLILKQALWQ 1683
             ++    ++   L  + +FC   ++++ I+D+ E YE++    L++L  +   L   +++
Sbjct: 514  CLNNDTEESKQLLAMLMLFCDCSRHLITILDDIEVYEEQISFKLEELVTISSFLNSFVFK 573

Query: 1684 LLWIIPSHTSPSQKALPNPLGLKKMSIDSLKSQARIGLSELLTQLQDW-------NSRLP 1842
            ++W                        D +   A+    EL   +  W       + R  
Sbjct: 574  MIW------------------------DGIVENAKGETLELFQSVHGWLMVLYERDCRRR 609

Query: 1843 FTAESDFYSQEATSENFVSQAILGNTRASEIIKLAPFLAPFTIRVKIFTSQLANSKQS-- 2016
            FT E  +  ++        +      RA  I++  P + P   RV +F + +   K+   
Sbjct: 610  FTPEDHWLRKDLKPSVLFQELDRDRKRAQLILQYIPHVIPHKNRVLLFRTMVTKEKEKLG 669

Query: 2017 ---TASHSALTRHRFKIRRSRLLEDAFDQLSLLSEEDLKGPIRVSFVNEHGVEEAGIDGG 2187
               T+S S    H   IRRSR+LED ++QL  LS+  +KG IRV FVN+ GV+EAGID  
Sbjct: 670  LVETSSASPHVTH-ITIRRSRMLEDGYEQLRQLSQHAMKGVIRVKFVNDLGVDEAGIDQD 728

Query: 2188 GIFKDFMENITRAAFDVQYGLFKETV-DHVLYPNPGSGLVHEQHLQYFHFLGSLLGKAMY 2364
            G+FK+F+E I +  FD    LFK T  D  LYP+P S  +HE +LQ F F+G +LGKA+Y
Sbjct: 729  GVFKEFLEEIIKRVFDPALNLFKTTSGDERLYPSPTS-YIHENYLQLFEFVGKMLGKAVY 787

Query: 2365 EGILVDLPFATFFLSKL--KEKSNF---LNDLPSLDPELYRHLLFLKHYKGDVSDLELYF 2529
            EGI+VD+PFA+FFLS+L     S F   +++LPSLD E Y++L  +K Y GD++DL L  
Sbjct: 788  EGIVVDVPFASFFLSQLLGHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDITDLGLTL 847

Query: 2530 VIVNNEYGEQAEEELLPGGREMRVTNQNVITFIHLVANHRLNYQIRGQGRHFLRGFQKLI 2709
                +  G+    EL+PGG+ + VTN+N I++IHL+A+ R++ QI+ Q    + GF+ +I
Sbjct: 848  SYDEDVMGQLVCHELIPGGKTIPVTNENKISYIHLMAHFRMHTQIKNQTAALISGFRSII 907

Query: 2710 PKEWIDMFNEHEIQLLISGSLESLDIDDLRLNTNYSGGYHPDHEIIDMLWEVLKS-FSSD 2886
              EWI MF+  E+Q LISG    +D++DL+ +T Y GG+H  H +I  LW++L S F+ D
Sbjct: 908  KPEWIRMFSTPELQRLISGDNAEIDLEDLKKHTVYYGGFHGSHRVIIWLWDILASDFTPD 967

Query: 2887 NQKKFLKFVTGCSRGPLLGFEYLDPKFCIQRAGVPGLEEHGD------------------ 3012
             +  FLKFVT CSR PLLGF YL P F I+   V   ++ GD                  
Sbjct: 968  ERAMFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFTIRKREPG 1027

Query: 3013 -RLPTSATCMNLLKLPPYRTKEQLQTKLLYAINSEAGFDLS 3132
             RLPTS+TC NLLKLP Y  K  L+ KL YAI+   GF+LS
Sbjct: 1028 GRLPTSSTCFNLLKLPNYSKKSVLREKLRYAISMNTGFELS 1068

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>Q08CZ0:UBE3B_XENTR Ubiquitin-protein ligase E3B - Xenopus tropicalis (Western clawed|
            frog) (Silurana tropicalis)
          Length = 1072

 Score =  375 bits (964), Expect = e-103
 Identities = 235/640 (36%), Positives = 344/640 (53%), Gaps = 41/640 (6%)
 Frame = +1

Query: 1336 EVEAVGSICAFLHVMFSTLP---LDVTMTALAYRTDIVPALWNFIKRCHENQRWPYFSKY 1506
            EV+ V +IC    +  +TL    L + +T L Y  D++P LW FI           F + 
Sbjct: 460  EVQKVCNICVLYQMALTTLTQIRLQI-LTGLTYLDDLLPKLWAFICELGPQGGLKLFLEC 518

Query: 1507 ISPLPVDAPGWLLPVSVFCPIYKYMLKIVDNEEFYEQEKPLSLKDLKALVLILKQALWQL 1686
            +S    ++   L  + +FC   ++++ I+D+ E YE++    L++L  +   L   ++++
Sbjct: 519  LSSDTEESRRLLAMLVLFCDCSRHLITILDDIEVYEEQISFKLEELVTISSFLNSFVFKM 578

Query: 1687 LWIIPSHTSPSQKALPNPLGLKKMSIDSLKSQARIGLSELLTQLQDW-------NSRLPF 1845
            +W                        D L   A+    EL   +  W       + R  F
Sbjct: 579  IW------------------------DGLLENAKGETLELFHSVHGWLMVLYERDCRRRF 614

Query: 1846 TAESDFYSQEATSENFVSQAILGNTRASEIIKLAPFLAPFTIRVKIFTSQLANSKQS--- 2016
              E  +  ++        +      RA  +++  P + P   RV +F + +   K+    
Sbjct: 615  APEDHWLRKDLKPTLLFQELDKERKRAQLLLQYIPHVIPHKNRVLLFRNIVTKEKEKLGL 674

Query: 2017 --TASHSALTRHRFKIRRSRLLEDAFDQLSLLSEEDLKGPIRVSFVNEHGVEEAGIDGGG 2190
              T + S    H   IRRSR+LED +DQL  LS+  +KG IRV FVN+ GV+EAGID  G
Sbjct: 675  VETNTASPHVTH-ITIRRSRMLEDGYDQLRQLSQNAMKGVIRVKFVNDLGVDEAGIDQDG 733

Query: 2191 IFKDFMENITRAAFDVQYGLFKETVD-HVLYPNPGSGLVHEQHLQYFHFLGSLLGKAMYE 2367
            +FK+F+E I +  FD    LFK T     LYP+P S  +HE +LQ F F+G +LGKA+YE
Sbjct: 734  VFKEFLEEIIKRVFDPALNLFKTTSSGDRLYPSPTS-YIHENYLQLFEFVGKMLGKAVYE 792

Query: 2368 GILVDLPFATFFLSKLKEKSNFL-----NDLPSLDPELYRHLLFLKHYKGDVSDLELYFV 2532
            GI+VD+PFA+FFLS+L    + +     ++LPSLD E Y++L  +K Y GD+SDL L   
Sbjct: 793  GIVVDVPFASFFLSQLLGHHHSIFYSSVDELPSLDSEFYKNLTSIKRYDGDISDLGLTLS 852

Query: 2533 IVNNEYGEQAEEELLPGGREMRVTNQNVITFIHLVANHRLNYQIRGQGRHFLRGFQKLIP 2712
               +  G+    EL+PGG+ + VTN+N I++IHL+A+ R++ QI+ Q   F+ GF+ +I 
Sbjct: 853  YDEDVMGQLVCHELVPGGKSIPVTNENKISYIHLMAHFRMHTQIKNQTVAFISGFRSIIR 912

Query: 2713 KEWIDMFNEHEIQLLISGSLESLDIDDLRLNTNYSGGYHPDHEIIDMLWEVL-KSFSSDN 2889
             EWI MF+  E+Q LISG    +D+DDL+ +T Y GG+H  H +I  LW++L   FSS+ 
Sbjct: 913  PEWIRMFSAPELQRLISGDNAEIDLDDLKKHTVYYGGFHGSHRVIIWLWDILANDFSSEE 972

Query: 2890 QKKFLKFVTGCSRGPLLGFEYLDPKFCIQRAGVPGLEEHGD------------------- 3012
            +  FLKFVT CSR PLLGF YL P F I+   V   ++ GD                   
Sbjct: 973  KAMFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFTIRKKEPGG 1032

Query: 3013 RLPTSATCMNLLKLPPYRTKEQLQTKLLYAINSEAGFDLS 3132
            RLPTS+TC NLLKLP Y  K  L+ KL YAI+   GF+LS
Sbjct: 1033 RLPTSSTCFNLLKLPNYSKKGILREKLRYAISMNTGFELS 1072

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>Q9ES34:UBE3B_MOUSE Ubiquitin-protein ligase E3B - Mus musculus (Mouse)|
          Length = 1070

 Score =  371 bits (953), Expect = e-101
 Identities = 231/641 (36%), Positives = 346/641 (53%), Gaps = 41/641 (6%)
 Frame = +1

Query: 1333 AEVEAVGSICAFLHVMFSTLP---LDVTMTALAYRTDIVPALWNFIKRCHENQRWPYFSK 1503
            AEV  V +IC       +TL    L + +T L Y  D++P LW FI     +     F +
Sbjct: 457  AEVRKVCNICVLYQTSLTTLTQIRLQI-LTGLTYLDDLLPKLWAFICELGPHGGLKLFLE 515

Query: 1504 YISPLPVDAPGWLLPVSVFCPIYKYMLKIVDNEEFYEQEKPLSLKDLKALVLILKQALWQ 1683
             ++    ++   L  + +FC   ++++ I+D+ E YE++    L++L  +   L   +++
Sbjct: 516  CLNNDTGESKQLLAMLMLFCDCSRHLITILDDIEVYEEQISFKLEELVTISSFLNSFVFK 575

Query: 1684 LLWIIPSHTSPSQKALPNPLGLKKMSIDSLKSQARIGLSELLTQLQDW-------NSRLP 1842
            ++W                        D +   A+    EL   +  W       + R  
Sbjct: 576  MIW------------------------DGIVENAKGETLELFQSVHGWLMVLYERDCRRR 611

Query: 1843 FTAESDFYSQEATSENFVSQAILGNTRASEIIKLAPFLAPFTIRVKIFTSQLANSKQS-- 2016
            F  E  +  ++        +      RA  +++  P + P   RV +F + +   K+   
Sbjct: 612  FAPEDHWLRRDLKPGVLFQELDKDRRRAQLVLQHIPHVVPHKNRVLLFRNMVIKEKEKLG 671

Query: 2017 ---TASHSALTRHRFKIRRSRLLEDAFDQLSLLSEEDLKGPIRVSFVNEHGVEEAGIDGG 2187
               T+S S    H   IRRSR+LED ++QL  LS+  +KG IRV FVN+ GV+EAGID  
Sbjct: 672  LVETSSASPHVTH-ITIRRSRMLEDGYEQLRQLSQHAMKGVIRVKFVNDLGVDEAGIDQD 730

Query: 2188 GIFKDFMENITRAAFDVQYGLFKETV-DHVLYPNPGSGLVHEQHLQYFHFLGSLLGKAMY 2364
            G+FK+F+E I +  FD    LFK T  D  LYP+P S  +HE +LQ F F+G +LGKA+Y
Sbjct: 731  GVFKEFLEEIIKRVFDPALNLFKTTSGDERLYPSPTS-YIHENYLQLFEFVGKMLGKAVY 789

Query: 2365 EGILVDLPFATFFLSKL--KEKSNF---LNDLPSLDPELYRHLLFLKHYKGDVSDLELYF 2529
            EGI+VD+PFA+FFLS++     S F   +++LPSLD E Y++L  +K Y GD++DL L  
Sbjct: 790  EGIVVDVPFASFFLSQMLGHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDIADLGLTL 849

Query: 2530 VIVNNEYGEQAEEELLPGGREMRVTNQNVITFIHLVANHRLNYQIRGQGRHFLRGFQKLI 2709
                +  G+    EL+PGG+ + VT++N I++IHL+A+ R++ QI+ Q    + GF+ +I
Sbjct: 850  SYDEDVMGQLVCHELVPGGKTIPVTDENKISYIHLMAHFRMHTQIKNQTAALISGFRSII 909

Query: 2710 PKEWIDMFNEHEIQLLISGSLESLDIDDLRLNTNYSGGYHPDHEIIDMLWEVLKS-FSSD 2886
              EWI MF+  E+Q LISG    +D++DL+ +T Y GG+H  H +I  LW++L S F+ +
Sbjct: 910  KPEWIRMFSTPELQRLISGDNAEIDLEDLKKHTVYYGGFHGSHRVIIWLWDILASDFTPE 969

Query: 2887 NQKKFLKFVTGCSRGPLLGFEYLDPKFCIQRAGVPGLEEHGD------------------ 3012
             +  FLKFVT CSR PLLGF YL P F I+   V   ++ GD                  
Sbjct: 970  ERAMFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFTIRKREPG 1029

Query: 3013 -RLPTSATCMNLLKLPPYRTKEQLQTKLLYAINSEAGFDLS 3132
             RLPTS+TC NLLKLP Y  K  L+ KL YAI+   GF+LS
Sbjct: 1030 GRLPTSSTCFNLLKLPNYSKKSVLREKLRYAISMNTGFELS 1070

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>Q80U95:UBE3C_MOUSE Ubiquitin-protein ligase E3C - Mus musculus (Mouse)|
          Length = 1083

 Score =  359 bits (922), Expect = 4e-98
 Identities = 194/408 (47%), Positives = 267/408 (65%), Gaps = 4/408 (0%)
 Frame = +1

Query: 1921 RASEIIKLAPFLAPFTIRVKIFTSQLANSKQSTASHSA-LTRHRFKIRRSRLLEDAFDQL 2097
            R   I+   PF+ PF  RVKIF   +   KQ        L      IRR+ + EDA+D+L
Sbjct: 681  RQLAILTELPFVVPFEERVKIFQRLIYADKQEVQGDGPFLDGINVTIRRNYIYEDAYDKL 740

Query: 2098 SLLSEEDLKGPIRVSFVNEHGVEEAGIDGGGIFKDFMENITRAAFDVQYGLFKETVDHVL 2277
            S  +E DLK  IRV  +N HG++EAGIDGGGIF++F+  + ++ F+   G FK T + +L
Sbjct: 741  SPENEPDLKKRIRVHLLNAHGLDEAGIDGGGIFREFLNELLKSGFNPNQGFFKTTNEGLL 800

Query: 2278 YPNPGSG-LVHEQHLQYFHFLGSLLGKAMYEGILVDLPFATFFLSKLKEKSNF--LNDLP 2448
            YPNP +  LV +   ++++FLG +LGKA+YE +LV+LPFA FFLSKL   S    ++ L 
Sbjct: 801  YPNPAAQMLVGDSFARHYYFLGRMLGKALYENMLVELPFAGFFLSKLLGTSADVDIHHLA 860

Query: 2449 SLDPELYRHLLFLKHYKGDVSDLELYFVIVNNEYGEQAEEELLPGGREMRVTNQNVITFI 2628
            SLDPE+YR+LLFLK Y+ DV +L L F +VNN+ GE    EL  GG+++ VT  N I +I
Sbjct: 861  SLDPEVYRNLLFLKSYEEDVEELGLNFTVVNNDLGEAQVVELKFGGKDIPVTGANRIAYI 920

Query: 2629 HLVANHRLNYQIRGQGRHFLRGFQKLIPKEWIDMFNEHEIQLLISGSLESLDIDDLRLNT 2808
            HLVA++RLN QIR     F +G   ++  EW+ MF++ EIQ+LISG+   + ++DL+  T
Sbjct: 921  HLVADYRLNKQIRPHCLAFRQGLANVVSLEWLRMFDQQEIQVLISGAQVPVSLEDLKSFT 980

Query: 2809 NYSGGYHPDHEIIDMLWEVLKSFSSDNQKKFLKFVTGCSRGPLLGFEYLDPKFCIQRAGV 2988
            NYSGGY  DH +I + W V++ F+ + ++K LKFVT CSR PLLGF+ L P FCI   G 
Sbjct: 981  NYSGGYSADHPVIKIFWRVVEGFTDEEKRKLLKFVTSCSRPPLLGFKELYPAFCIHNGG- 1039

Query: 2989 PGLEEHGDRLPTSATCMNLLKLPPYRTKEQLQTKLLYAINSEAGFDLS 3132
                   +RLPT++TCMNLLKLP +  +  L++KLLYAI   AGF+LS
Sbjct: 1040 ----SDLERLPTASTCMNLLKLPEFYDEALLRSKLLYAIECAAGFELS 1083

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>Q15386:UBE3C_HUMAN Ubiquitin-protein ligase E3C - Homo sapiens (Human)|
          Length = 1083

 Score =  359 bits (921), Expect = 5e-98
 Identities = 192/408 (47%), Positives = 268/408 (65%), Gaps = 4/408 (0%)
 Frame = +1

Query: 1921 RASEIIKLAPFLAPFTIRVKIFTSQLANSKQSTASHSA-LTRHRFKIRRSRLLEDAFDQL 2097
            R   ++   PF+ PF  RVKIF   +   KQ        L      IRR+ + EDA+D+L
Sbjct: 681  RQLAVLTELPFVVPFEERVKIFQRLIYADKQEVQGDGPFLDGINVTIRRNYIYEDAYDKL 740

Query: 2098 SLLSEEDLKGPIRVSFVNEHGVEEAGIDGGGIFKDFMENITRAAFDVQYGLFKETVDHVL 2277
            S  +E DLK  IRV  +N HG++EAGIDGGGIF++F+  + ++ F+   G FK T + +L
Sbjct: 741  SPENEPDLKKRIRVHLLNAHGLDEAGIDGGGIFREFLNELLKSGFNPNQGFFKTTNEGLL 800

Query: 2278 YPNPGSG-LVHEQHLQYFHFLGSLLGKAMYEGILVDLPFATFFLSKLKEKSNF--LNDLP 2448
            YPNP +  LV +   ++++FLG +LGKA+YE +LV+LPFA FFLSKL   S    ++ L 
Sbjct: 801  YPNPAAQMLVGDSFARHYYFLGRMLGKALYENMLVELPFAGFFLSKLLGTSADVDIHHLA 860

Query: 2449 SLDPELYRHLLFLKHYKGDVSDLELYFVIVNNEYGEQAEEELLPGGREMRVTNQNVITFI 2628
            SLDPE+Y++LLFLK Y+ DV +L L F +VNN+ GE    EL  GG+++ VT+ N I +I
Sbjct: 861  SLDPEVYKNLLFLKSYEDDVEELGLNFTVVNNDLGEAQVVELKFGGKDIPVTSANRIAYI 920

Query: 2629 HLVANHRLNYQIRGQGRHFLRGFQKLIPKEWIDMFNEHEIQLLISGSLESLDIDDLRLNT 2808
            HLVA++RLN QIR     F +G   ++  EW+ MF++ EIQ+LISG+   + ++DL+  T
Sbjct: 921  HLVADYRLNRQIRQHCLAFRQGLANVVSLEWLRMFDQQEIQVLISGAQVPISLEDLKSFT 980

Query: 2809 NYSGGYHPDHEIIDMLWEVLKSFSSDNQKKFLKFVTGCSRGPLLGFEYLDPKFCIQRAGV 2988
            NYSGGY  DH +I + W V++ F+ + ++K LKFVT CSR PLLGF+ L P FCI   G 
Sbjct: 981  NYSGGYSADHPVIKVFWRVVEGFTDEEKRKLLKFVTSCSRPPLLGFKELYPAFCIHNGG- 1039

Query: 2989 PGLEEHGDRLPTSATCMNLLKLPPYRTKEQLQTKLLYAINSEAGFDLS 3132
                   +RLPT++TCMNLLKLP +  +  L++KLLYAI   AGF+LS
Sbjct: 1040 ----SDLERLPTASTCMNLLKLPEFYDETLLRSKLLYAIECAAGFELS 1083

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>P53119:HUL5_YEAST Probable E3 ubiquitin-protein ligase HUL5 - Saccharomyces cerevisiae|
            (Baker's yeast)
          Length = 910

 Score =  259 bits (663), Expect = 4e-68
 Identities = 169/424 (39%), Positives = 240/424 (56%), Gaps = 20/424 (4%)
 Frame = +1

Query: 1921 RASEIIKLAPFLAPFTIRVKIFTSQLANSKQSTA--------------SHSALTRHRFKI 2058
            R  EI+   PF  PF  RV +F   +A  K+  +              + + + +    I
Sbjct: 499  RKLEILLELPFFIPFEERVDLFYMFIALDKKRLSLDDDHNLINMFTPWASTGMRKQSAII 558

Query: 2059 RRSRLLEDAFDQLSLLSEEDLKGPIRVSFVNEHGVEEAGIDGGGIFKDFMENITRAAF-D 2235
             R  +LEDAF+  + + E   K  + V+F+NE G EEAGIDGGGI K+F+  ++   F D
Sbjct: 559  SRDNVLEDAFNAFNSIGER-FKASLDVTFINEFG-EEAGIDGGGITKEFLTTVSDEGFKD 616

Query: 2236 VQYGLFKETVDHVLYPNPGSGLVHEQHLQYFHFLGSLLGKAMYEGILVDLPFATFFLSKL 2415
             ++ LF+    + LYP   S +     L+Y  FLG ++GK +YE +L+D+ FA FFL KL
Sbjct: 617  PKHELFRTNDRYELYP---SVVYDATKLKYIWFLGKVVGKCLYEHVLIDVSFADFFLKKL 673

Query: 2416 KEKSN-FLN---DLPSLDPELYRHLLFLKHYKGD-VSDLELYFVIVNNEYGEQAEEELLP 2580
               SN FL+   DL S D  LY +L+ L +   D +  L+L F I   E   +  + L+P
Sbjct: 674  LNYSNGFLSSFSDLGSYDSVLYNNLIKLLNMTTDEIKSLDLTFEIDEPESSAKVVD-LIP 732

Query: 2581 GGREMRVTNQNVITFIHLVANHRLNYQIRGQGRHFLRGFQKLIPKEWIDMFNEHEIQLLI 2760
             G +  VT  NV+ ++  V +++LN +       F  G   +I   W++MFN  E+Q+LI
Sbjct: 733  NGSKTYVTKDNVLLYVTKVTDYKLNKRCFKPVSAFHGGLSVIIAPHWMEMFNSIELQMLI 792

Query: 2761 SGSLESLDIDDLRLNTNYSGGYHPDHEIIDMLWEVLKSFSSDNQKKFLKFVTGCSRGPLL 2940
            SG  +++D+DDL+ NT Y G    D  I+D  WEVL  F  + +  FLKFVT   + PL 
Sbjct: 793  SGERDNIDLDDLKSNTEYGGYKEEDQTIVD-FWEVLNEFKFEEKLNFLKFVTSVPQAPLQ 851

Query: 2941 GFEYLDPKFCIQRAGVPGLEEHGDRLPTSATCMNLLKLPPYRTKEQLQTKLLYAINSEAG 3120
            GF+ LDPKF I+ AG    E++  RLPT++TC+NLLKLP YR K  L+ KLLYAINS A 
Sbjct: 852  GFKALDPKFGIRNAGT---EKY--RLPTASTCVNLLKLPDYRNKTILREKLLYAINSGAR 906

Query: 3121 FDLS 3132
            FDLS
Sbjct: 907  FDLS 910

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>Q8GY23:UPL1_ARATH E3 ubiquitin-protein ligase UPL1 - Arabidopsis thaliana (Mouse-ear|
            cress)
          Length = 3684

 Score =  233 bits (595), Expect = 3e-60
 Identities = 154/416 (37%), Positives = 230/416 (55%), Gaps = 10/416 (2%)
 Frame = +1

Query: 1945 APFLAPFTIRVKIFTSQLANSKQSTASHSALTRHRFKIRRSRLLEDAFDQLSLLSEEDLK 2124
            AP L  F  +   F S++ +      S       R  +RR+ +LED+++QL + S +DLK
Sbjct: 3290 APRLIDFDNKKAYFRSRIRHQHDQHISGPL----RISVRRAYVLEDSYNQLRMRSPQDLK 3345

Query: 2125 GPIRVSFVNEHGVEEAGIDGGGIFKDFMENITRAAFDVQYGLFKETV-DHVLYPNPGSGL 2301
            G + V F  E G     ID GG+ +++ + ++R  FD    LF     D    PNP S +
Sbjct: 3346 GRLNVQFQGEEG-----IDAGGLTREWYQLLSRVIFDKGALLFTTVGNDATFQPNPNS-V 3399

Query: 2302 VHEQHLQYFHFLGSLLGKAMYEGILVDLPFATFFLSKLKEKSNFLNDLPSLDPELYRHLL 2481
               +HL YF F+G ++ KA+++G L+D+ F   F   +       +D+ ++DP+ Y++L 
Sbjct: 3400 YQTEHLSYFKFVGRMVAKALFDGQLLDVYFTRSFYKHILGVKVTYHDIEAVDPDYYKNLK 3459

Query: 2482 FLKHYKGDVSD-LELYFVI-------VNNEYGEQAEEELLPGGREMRVTNQNVITFIHLV 2637
            +L   + DVSD L+L F +       +  E  E  + EL PGGR +RVT +    ++ LV
Sbjct: 3460 WL--LENDVSDILDLTFSMDADEEKHILYEKTEVTDYELKPGGRNIRVTEETKHEYVDLV 3517

Query: 2638 ANHRLNYQIRGQGRHFLRGFQKLIPKEWIDMFNEHEIQLLISGSLESLDIDDLRLNTNYS 2817
            A H L   IR Q   FL GF +LIP+E + +FN+ E++LLISG L  +D DDL+ NT Y+
Sbjct: 3518 AGHILTNAIRPQINAFLEGFNELIPRELVSIFNDKELELLISG-LPEIDFDDLKANTEYT 3576

Query: 2818 GGYHPDHEIIDMLWEVLKSFSSDNQKKFLKFVTGCSRGPLLGFEYLDPKFCIQRAGVPGL 2997
              Y     +I   WEV+K+FS ++  +FL+FVTG S+ PL GF+ L      QR  +   
Sbjct: 3577 -SYTAGSPVIHWFWEVVKAFSKEDMARFLQFVTGTSKVPLEGFKALQGISGPQRLQIHKA 3635

Query: 2998 EEHGDRLPTSATCMNLLKLPPYRTKEQLQTKLLYAIN-SEAGFDLS*LHCGFGHCA 3162
                +RLP++ TC N L LP Y++KEQLQ +LL AI+ +  GF       GF H A
Sbjct: 3636 YGAPERLPSAHTCFNQLDLPEYQSKEQLQERLLLAIHEASEGF-------GFAHTA 3684

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>Q8H0T4:UPL2_ARATH E3 ubiquitin-protein ligase UPL2 - Arabidopsis thaliana (Mouse-ear|
            cress)
          Length = 3658

 Score =  228 bits (581), Expect = 1e-58
 Identities = 146/397 (36%), Positives = 223/397 (56%), Gaps = 9/397 (2%)
 Frame = +1

Query: 1945 APFLAPFTIRVKIFTSQLANSKQSTASHSALTRHRFKIRRSRLLEDAFDQLSLLSEEDLK 2124
            AP L  F  +   F S++ +      S       R  +RR+ +LED+++QL + S +DLK
Sbjct: 3267 APRLIDFDNKKAYFRSRIRHQHDQHISGPL----RISVRRAYVLEDSYNQLRMRSPQDLK 3322

Query: 2125 GPIRVSFVNEHGVEEAGIDGGGIFKDFMENITRAAFDVQYGLFKETV-DHVLYPNPGSGL 2301
            G + V F  E G     ID GG+ +++ + ++R  FD    LF     D    PNP S +
Sbjct: 3323 GRLNVQFQGEEG-----IDAGGLTREWYQLLSRVIFDKGALLFTTVGNDATFQPNPNS-V 3376

Query: 2302 VHEQHLQYFHFLGSLLGKAMYEGILVDLPFATFFLSKLKEKSNFLNDLPSLDPELYRHLL 2481
               +HL YF F+G ++ KA+++G L+D+ F   F   +       +D+ ++DP+ Y++L 
Sbjct: 3377 YQTEHLSYFKFVGRMVAKALFDGQLLDVYFTRSFYKHILGVKVTYHDIEAVDPDYYKNLK 3436

Query: 2482 FLKHYKGDVSD-LELYFVI-------VNNEYGEQAEEELLPGGREMRVTNQNVITFIHLV 2637
            +L   + DVSD L+L F +       +  E  E  + EL PGGR +RVT +    ++ LV
Sbjct: 3437 WL--LENDVSDILDLTFSMDADEEKHILYEKTEVTDYELKPGGRNIRVTEETKHEYVDLV 3494

Query: 2638 ANHRLNYQIRGQGRHFLRGFQKLIPKEWIDMFNEHEIQLLISGSLESLDIDDLRLNTNYS 2817
            A+H L   IR Q   FL G  +LIP+E + +FN+ E++LLISG L  +D DDL+ NT Y+
Sbjct: 3495 ADHILTSAIRPQINAFLEGLNELIPRELVSIFNDKELELLISG-LPEIDFDDLKANTEYT 3553

Query: 2818 GGYHPDHEIIDMLWEVLKSFSSDNQKKFLKFVTGCSRGPLLGFEYLDPKFCIQRAGVPGL 2997
              Y     +I   WEV+K+FS ++  +FL+FVTG S+ PL GF+ L      QR  +   
Sbjct: 3554 S-YTVGSPVIRWFWEVVKAFSKEDMARFLQFVTGTSKVPLEGFKALQGISGPQRLQIHKA 3612

Query: 2998 EEHGDRLPTSATCMNLLKLPPYRTKEQLQTKLLYAIN 3108
                +RLP++ TC N L LP Y++KEQ+Q +LL AI+
Sbjct: 3613 YGSPERLPSAHTCFNQLDLPEYQSKEQVQERLLLAIH 3649

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>Q9VVI3:NEDD4_DROME E3 ubiquitin-protein ligase Nedd-4 - Drosophila melanogaster (Fruit|
            fly)
          Length = 1007

 Score =  225 bits (573), Expect = 1e-57
 Identities = 134/369 (36%), Positives = 211/369 (57%), Gaps = 8/369 (2%)
 Frame = +1

Query: 2041 RHRFKIRRSRLLEDAFDQLSLLSEEDL-KGPIRVSFVNEHGVEEAGIDGGGIFKDFMENI 2217
            +   +IRR+ +LED++  +S +++ DL K  + V F  E      G+D GG+ +++   +
Sbjct: 649  KFEIRIRRTSILEDSYRIISSVTKTDLLKTKLWVEFEGE-----TGLDYGGLAREWFYLL 703

Query: 2218 TRAAFDVQYGLFKETV--DHVLYPNPGSGLVHEQHLQYFHFLGSLLGKAMYEGILVDLPF 2391
            ++  F+  YGLF+ +   ++ L  N GSGL +E+HL YF F+G + G A+Y G L+D  F
Sbjct: 704  SKEMFNPYYGLFEYSAMDNYTLQINNGSGLCNEEHLSYFKFIGRIAGMAVYHGKLLDAFF 763

Query: 2392 ATFFLSKLKEKSNFLNDLPSLDPELYRHLLFLKHYKGDVSDLELYFVIVNNEYGEQAEEE 2571
               F   + +K   L D+ S+D E Y  L+++K  + D   LEL F +  + +G++++ E
Sbjct: 764  IRPFYKMMLQKPIDLKDMESVDTEYYNSLMWIK--ENDPRILELTFCLDEDVFGQKSQHE 821

Query: 2572 LLPGGREMRVTNQNVITFIHLVANHRLNYQIRGQGRHFLRGFQKLIPKEWIDMFNEHEIQ 2751
            L PGG  + VTN+N   +I LV   R   +++ Q   FL GF  +IP   I +F+EHE++
Sbjct: 822  LKPGGANIDVTNENKDEYIKLVIEWRFVARVKEQMSSFLDGFGSIIPLNLIKIFDEHELE 881

Query: 2752 LLISGSLESLDIDDLRLNTNYSGGYHPDHEIIDMLWEVLKSFSSDNQKKFLKFVTGCSRG 2931
            LL+ G ++++D+ D R NT Y G YH +H II   W  + SFS++ + + L+FVTG SR 
Sbjct: 882  LLMCG-IQNIDVKDWRENTLYKGDYHMNHIIIQWFWRAVLSFSNEMRSRLLQFVTGTSRV 940

Query: 2932 PLLGFEYL-----DPKFCIQRAGVPGLEEHGDRLPTSATCMNLLKLPPYRTKEQLQTKLL 3096
            P+ GF+ L        F I++ G P      +  P + TC N L LPPY    QL+ KL+
Sbjct: 941  PMNGFKELYGSNGPQMFTIEKWGTP------NNFPRAHTCFNRLDLPPYEGYLQLKDKLI 994

Query: 3097 YAINSEAGF 3123
             AI    GF
Sbjct: 995  KAIEGSQGF 1003

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>P46935:NEDD4_MOUSE E3 ubiquitin-protein ligase NEDD4 - Mus musculus (Mouse)|
          Length = 887

 Score =  214 bits (545), Expect = 2e-54
 Identities = 130/370 (35%), Positives = 210/370 (56%), Gaps = 8/370 (2%)
 Frame = +1

Query: 2041 RHRFKIRRSRLLEDAFDQLSLLSEEDL-KGPIRVSFVNEHGVEEAGIDGGGIFKDFMENI 2217
            +   K+RR+ +LED++ ++  +   DL K  + + F  E G     +D GG+ +++   I
Sbjct: 529  KFEMKLRRANILEDSYRRIMGVKRADLLKARLWIEFDGEKG-----LDYGGVAREWFFLI 583

Query: 2218 TRAAFDVQYGLFK--ETVDHVLYPNPGSGLVHEQHLQYFHFLGSLLGKAMYEGILVDLPF 2391
            ++  F+  YGLF+   T ++ L  NP SGL +E HL YF F+G + G A+Y G L+D  F
Sbjct: 584  SKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFF 643

Query: 2392 ATFFLSKLKEKSNFLNDLPSLDPELYRHLLFLKHYKGDVSDLELYFVIVNNEYGEQAEEE 2571
               F   + +K   L+D+ S+D E Y  L ++   + D ++L+L F+I    +G+  + E
Sbjct: 644  IRPFYKMMLQKLITLHDMESVDSEYYSSLRWI--LENDPTELDLRFIIDEELFGQTHQHE 701

Query: 2572 LLPGGREMRVTNQNVITFIHLVANHRLNYQIRGQGRHFLRGFQKLIPKEWIDMFNEHEIQ 2751
            L  GG E+ VTN+N   +I+LV   R   +I+ Q   F  GF +LIP++ I +F+E+E++
Sbjct: 702  LKTGGSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELE 761

Query: 2752 LLISGSLESLDIDDLRLNTNYSGGYHPDHEIIDMLWEVLKSFSSDNQKKFLKFVTGCSRG 2931
            LL+ G L  +D++D R +T Y  GY  +H++I   W+ +    S+ + + L+FVTG SR 
Sbjct: 762  LLMCG-LGDVDVNDWREHTKYKNGYSMNHQVIHWFWKAVWMMDSEKRIRLLQFVTGTSRV 820

Query: 2932 PLLGFEYL-----DPKFCIQRAGVPGLEEHGDRLPTSATCMNLLKLPPYRTKEQLQTKLL 3096
            P+ GF  L        F +++ G P      D+LP + TC N L LPPY + ++L  KL 
Sbjct: 821  PMNGFAELYGSNGPQSFTVEQWGTP------DKLPRAHTCFNRLDLPPYESFDELWDKLQ 874

Query: 3097 YAINSEAGFD 3126
             AI +  GFD
Sbjct: 875  MAIENTQGFD 884

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>P46934:NEDD4_HUMAN E3 ubiquitin-protein ligase NEDD4 - Homo sapiens (Human)|
          Length = 1000

 Score =  214 bits (544), Expect = 3e-54
 Identities = 130/370 (35%), Positives = 209/370 (56%), Gaps = 8/370 (2%)
 Frame = +1

Query: 2041 RHRFKIRRSRLLEDAFDQLSLLSEED-LKGPIRVSFVNEHGVEEAGIDGGGIFKDFMENI 2217
            +   K+RR+ +LED++ ++  +   D LK  + + F  E G     +D GG+ +++   I
Sbjct: 642  KFEMKLRRATVLEDSYRRIMGVKRADFLKARLWIEFDGEKG-----LDYGGVAREWFFLI 696

Query: 2218 TRAAFDVQYGLFK--ETVDHVLYPNPGSGLVHEQHLQYFHFLGSLLGKAMYEGILVDLPF 2391
            ++  F+  YGLF+   T ++ L  NP SGL +E HL YF F+G + G A+Y G L+D  F
Sbjct: 697  SKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFF 756

Query: 2392 ATFFLSKLKEKSNFLNDLPSLDPELYRHLLFLKHYKGDVSDLELYFVIVNNEYGEQAEEE 2571
               F   +  K   L+D+ S+D E Y  L ++   + D ++L+L F+I    +G+  + E
Sbjct: 757  IRPFYKMMLHKPITLHDMESVDSEYYNSLRWI--LENDPTELDLRFIIDEELFGQTHQHE 814

Query: 2572 LLPGGREMRVTNQNVITFIHLVANHRLNYQIRGQGRHFLRGFQKLIPKEWIDMFNEHEIQ 2751
            L  GG E+ VTN+N   +I+LV   R   +I+ Q   F  GF +LIP++ I +F+E+E++
Sbjct: 815  LKNGGSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELE 874

Query: 2752 LLISGSLESLDIDDLRLNTNYSGGYHPDHEIIDMLWEVLKSFSSDNQKKFLKFVTGCSRG 2931
            LL+ G L  +D++D R +T Y  GY  +H++I   W+ +    S+ + + L+FVTG SR 
Sbjct: 875  LLMCG-LGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRV 933

Query: 2932 PLLGFEYL-----DPKFCIQRAGVPGLEEHGDRLPTSATCMNLLKLPPYRTKEQLQTKLL 3096
            P+ GF  L        F +++ G P      ++LP + TC N L LPPY + E+L  KL 
Sbjct: 934  PMNGFAELYGSNGPQSFTVEQWGTP------EKLPRAHTCFNRLDLPPYESFEELWDKLQ 987

Query: 3097 YAINSEAGFD 3126
             AI +  GFD
Sbjct: 988  MAIENTQGFD 997

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>Q62940:NEDD4_RAT E3 ubiquitin-protein ligase NEDD4 - Rattus norvegicus (Rat)|
          Length = 887

 Score =  213 bits (542), Expect = 4e-54
 Identities = 129/371 (34%), Positives = 210/371 (56%), Gaps = 9/371 (2%)
 Frame = +1

Query: 2041 RHRFKIRRSRLLEDAFDQLSLLSEED-LKGPIRVSFVNEHGVEEAGIDGGGIFKDFMENI 2217
            +   K+RR+ +LED++ ++  +   D LK  + + F  E G     +D GG+ +++   I
Sbjct: 528  KFEMKLRRANILEDSYRRIMGVKRADFLKARLWIEFDGEKG-----LDYGGVAREWFFLI 582

Query: 2218 TRAAFDVQYGLFKETV---DHVLYPNPGSGLVHEQHLQYFHFLGSLLGKAMYEGILVDLP 2388
            ++  F+  YGLF+ +    ++ L  NP SGL +E HL YF F+G + G A+Y G L+D  
Sbjct: 583  SKEMFNPYYGLFEYSATEDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGF 642

Query: 2389 FATFFLSKLKEKSNFLNDLPSLDPELYRHLLFLKHYKGDVSDLELYFVIVNNEYGEQAEE 2568
            F   F   + +K   L+D+ S+D E Y  L ++   + D ++L+L F+I    +G+  + 
Sbjct: 643  FIRPFYKMMLQKLITLHDMESVDSEYYSSLRWI--LENDPTELDLRFIIDEELFGQTHQH 700

Query: 2569 ELLPGGREMRVTNQNVITFIHLVANHRLNYQIRGQGRHFLRGFQKLIPKEWIDMFNEHEI 2748
            EL  GG E+ VTN+N   +I+LV   R   +I+ Q   F  GF +LIP++ I +F+E+E+
Sbjct: 701  ELKTGGSEVVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENEL 760

Query: 2749 QLLISGSLESLDIDDLRLNTNYSGGYHPDHEIIDMLWEVLKSFSSDNQKKFLKFVTGCSR 2928
            +LL+ G L  +D++D R +T Y  GY  +H++I   W+ +    S+ + + L+FVTG SR
Sbjct: 761  ELLMCG-LGDVDVNDWREHTKYKNGYSLNHQVIHWFWKAVLMMDSEKRIRLLQFVTGTSR 819

Query: 2929 GPLLGFEYL-----DPKFCIQRAGVPGLEEHGDRLPTSATCMNLLKLPPYRTKEQLQTKL 3093
             P+ GF  L        F +++ G P      D+LP + TC N L LPPY + ++L  KL
Sbjct: 820  VPMNGFAELYGSNGPQSFTVEQWGTP------DKLPRAHTCFNRLDLPPYESFDELWDKL 873

Query: 3094 LYAINSEAGFD 3126
              AI +  GFD
Sbjct: 874  QMAIENTQGFD 884

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>Q8CFI0:NED4L_MOUSE E3 ubiquitin-protein ligase NEDD4-like protein - Mus musculus (Mouse)|
          Length = 1004

 Score =  209 bits (532), Expect = 6e-53
 Identities = 125/370 (33%), Positives = 207/370 (55%), Gaps = 8/370 (2%)
 Frame = +1

Query: 2041 RHRFKIRRSRLLEDAFDQLSLLSEED-LKGPIRVSFVNEHGVEEAGIDGGGIFKDFMENI 2217
            R   K+ R+ + E+++ ++  +   D LK  + + F +E G     +D GG+ +++   +
Sbjct: 646  RFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKG-----LDYGGVAREWFFLL 700

Query: 2218 TRAAFDVQYGLFK--ETVDHVLYPNPGSGLVHEQHLQYFHFLGSLLGKAMYEGILVDLPF 2391
            ++  F+  YGLF+   T ++ L  NP SGL +E HL YF F+G + G A++ G L+D  F
Sbjct: 701  SKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFF 760

Query: 2392 ATFFLSKLKEKSNFLNDLPSLDPELYRHLLFLKHYKGDVSDLELYFVIVNNEYGEQAEEE 2571
               F   +  K   LND+ S+D E Y  L ++   + D ++L+L F I    +G+  + +
Sbjct: 761  IRPFYKMMLGKQITLNDMESVDSEYYNSLKWI--LENDPTELDLMFCIDEENFGQTYQVD 818

Query: 2572 LLPGGREMRVTNQNVITFIHLVANHRLNYQIRGQGRHFLRGFQKLIPKEWIDMFNEHEIQ 2751
            L P G E+ VTN+N   +I LV   R   +++ Q   FL GF +L+P + I +F+E+E++
Sbjct: 819  LKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELE 878

Query: 2752 LLISGSLESLDIDDLRLNTNYSGGYHPDHEIIDMLWEVLKSFSSDNQKKFLKFVTGCSRG 2931
            LL+ G L  +D++D R ++ Y  GY P+H +I   W+ +    ++ + + L+FVTG SR 
Sbjct: 879  LLMCG-LGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRV 937

Query: 2932 PLLGFEYL-----DPKFCIQRAGVPGLEEHGDRLPTSATCMNLLKLPPYRTKEQLQTKLL 3096
            P+ GF  L        F I++ G P      ++LP + TC N L LPPY T E L+ KLL
Sbjct: 938  PMNGFAELYGSNGPQLFTIEQWGSP------EKLPRAHTCFNRLDLPPYETFEDLREKLL 991

Query: 3097 YAINSEAGFD 3126
             A+ +  GF+
Sbjct: 992  MAVENAQGFE 1001

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>Q96PU5:NED4L_HUMAN E3 ubiquitin-protein ligase NEDD4-like protein - Homo sapiens (Human)|
          Length = 975

 Score =  209 bits (532), Expect = 6e-53
 Identities = 125/370 (33%), Positives = 207/370 (55%), Gaps = 8/370 (2%)
 Frame = +1

Query: 2041 RHRFKIRRSRLLEDAFDQLSLLSEED-LKGPIRVSFVNEHGVEEAGIDGGGIFKDFMENI 2217
            R   K+ R+ + E+++ ++  +   D LK  + + F +E G     +D GG+ +++   +
Sbjct: 617  RFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKG-----LDYGGVAREWFFLL 671

Query: 2218 TRAAFDVQYGLFK--ETVDHVLYPNPGSGLVHEQHLQYFHFLGSLLGKAMYEGILVDLPF 2391
            ++  F+  YGLF+   T ++ L  NP SGL +E HL YF F+G + G A++ G L+D  F
Sbjct: 672  SKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFF 731

Query: 2392 ATFFLSKLKEKSNFLNDLPSLDPELYRHLLFLKHYKGDVSDLELYFVIVNNEYGEQAEEE 2571
               F   +  K   LND+ S+D E Y  L ++   + D ++L+L F I    +G+  + +
Sbjct: 732  IRPFYKMMLGKQITLNDMESVDSEYYNSLKWI--LENDPTELDLMFCIDEENFGQTYQVD 789

Query: 2572 LLPGGREMRVTNQNVITFIHLVANHRLNYQIRGQGRHFLRGFQKLIPKEWIDMFNEHEIQ 2751
            L P G E+ VTN+N   +I LV   R   +++ Q   FL GF +L+P + I +F+E+E++
Sbjct: 790  LKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELE 849

Query: 2752 LLISGSLESLDIDDLRLNTNYSGGYHPDHEIIDMLWEVLKSFSSDNQKKFLKFVTGCSRG 2931
            LL+ G L  +D++D R ++ Y  GY P+H +I   W+ +    ++ + + L+FVTG SR 
Sbjct: 850  LLMCG-LGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRV 908

Query: 2932 PLLGFEYL-----DPKFCIQRAGVPGLEEHGDRLPTSATCMNLLKLPPYRTKEQLQTKLL 3096
            P+ GF  L        F I++ G P      ++LP + TC N L LPPY T E L+ KLL
Sbjct: 909  PMNGFAELYGSNGPQLFTIEQWGSP------EKLPRAHTCFNRLDLPPYETFEDLREKLL 962

Query: 3097 YAINSEAGFD 3126
             A+ +  GF+
Sbjct: 963  MAVENAQGFE 972

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>Q5RBF2:NED4L_PONPY E3 ubiquitin-protein ligase NEDD4-like protein - Pongo pygmaeus|
            (Orangutan)
          Length = 959

 Score =  209 bits (531), Expect = 8e-53
 Identities = 125/370 (33%), Positives = 207/370 (55%), Gaps = 8/370 (2%)
 Frame = +1

Query: 2041 RHRFKIRRSRLLEDAFDQLSLLSEED-LKGPIRVSFVNEHGVEEAGIDGGGIFKDFMENI 2217
            R   K+ R+ + E+++ ++  +   D LK  + + F +E G     +D GG+ +++   +
Sbjct: 601  RFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKG-----LDYGGVAREWFFLL 655

Query: 2218 TRAAFDVQYGLFK--ETVDHVLYPNPGSGLVHEQHLQYFHFLGSLLGKAMYEGILVDLPF 2391
            ++  F+  YGLF+   T ++ L  NP SGL +E HL YF F+G + G A++ G L+D  F
Sbjct: 656  SKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFF 715

Query: 2392 ATFFLSKLKEKSNFLNDLPSLDPELYRHLLFLKHYKGDVSDLELYFVIVNNEYGEQAEEE 2571
               F   +  K   LND+ S+D E Y  L ++   + D ++L+L F I    +G+  + +
Sbjct: 716  IRPFYKMMLGKQITLNDMESVDSEYYNSLKWI--LENDPTELDLMFCIDEENFGQTYQVD 773

Query: 2572 LLPGGREMRVTNQNVITFIHLVANHRLNYQIRGQGRHFLRGFQKLIPKEWIDMFNEHEIQ 2751
            L P G E+ VTN+N   +I LV   R   +++ Q   FL GF +L+P + I +F+E+E++
Sbjct: 774  LEPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELE 833

Query: 2752 LLISGSLESLDIDDLRLNTNYSGGYHPDHEIIDMLWEVLKSFSSDNQKKFLKFVTGCSRG 2931
            LL+ G L  +D++D R ++ Y  GY P+H +I   W+ +    ++ + + L+FVTG SR 
Sbjct: 834  LLMCG-LGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRV 892

Query: 2932 PLLGFEYL-----DPKFCIQRAGVPGLEEHGDRLPTSATCMNLLKLPPYRTKEQLQTKLL 3096
            P+ GF  L        F I++ G P      ++LP + TC N L LPPY T E L+ KLL
Sbjct: 893  PMNGFAELYGSNGPQLFTIEQWGSP------EKLPRAHTCFNRLDLPPYETFEDLREKLL 946

Query: 3097 YAINSEAGFD 3126
             A+ +  GF+
Sbjct: 947  MAVENAQGFE 956

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>Q9P4Z1:TOM1_NEUCR E3 ubiquitin-protein ligase TOM1-like protein - Neurospora crassa|
          Length = 4065

 Score =  204 bits (520), Expect = 2e-51
 Identities = 126/380 (33%), Positives = 207/380 (54%), Gaps = 9/380 (2%)
 Frame = +1

Query: 2011 QSTASHSALTRHRF-----KIRRSRLLEDAFDQLSLLSEEDLK-GPIRVSFVNEHGVEEA 2172
            +S  S    TRH F     ++RR  +  D+F  L     ++LK G + + F  E GV   
Sbjct: 3692 RSVHSKYQQTRHSFPPLQLQVRREHVFHDSFRSLYYKKADELKFGKLNIRFQGEEGV--- 3748

Query: 2173 GIDGGGIFKDFMENITRAAFDVQYGLFKETVDH--VLYPNPGSGLVHEQHLQYFHFLGSL 2346
              D GG+ +++ + ++R  FD  Y LF          +PN  S  ++++HL +F F+G +
Sbjct: 3749 --DAGGVTREWFQVLSRQMFDPNYVLFVPVSSDRTTFHPNKLSP-INDEHLPFFKFIGRI 3805

Query: 2347 LGKAMYEGILVDLPFATFFLSKLKEKSNFLNDLPSLDPELYRHLLFLKHYKGDVSDLELY 2526
            +GKA+YEG L++  F+     ++  K   + D+ S DP+ Y+ L+++   + D++D+   
Sbjct: 3806 IGKALYEGRLLECYFSRAVYKRILGKPVSVKDMESFDPDYYKSLVWM--LENDITDIITE 3863

Query: 2527 -FVIVNNEYGEQAEEELLPGGREMRVTNQNVITFIHLVANHRLNYQIRGQGRHFLRGFQK 2703
             F + ++ +GE    +L+  GR + VT +N   ++ L+  H+L   ++ Q + FL GF +
Sbjct: 3864 TFSVEDDVFGEVKVVDLIENGRNIPVTEENKHEYVRLIVEHKLITSVKDQMKAFLTGFHE 3923

Query: 2704 LIPKEWIDMFNEHEIQLLISGSLESLDIDDLRLNTNYSGGYHPDHEIIDMLWEVLKSFSS 2883
            +IP+E I +FNE E++LLISG L  +DIDD + NT Y   Y      I   W  ++SF  
Sbjct: 3924 IIPEELIAIFNEQELELLISG-LPDIDIDDWKANTEYH-NYSAGAPQIQWFWRAVRSFDK 3981

Query: 2884 DNQKKFLKFVTGCSRGPLLGFEYLDPKFCIQRAGVPGLEEHGDRLPTSATCMNLLKLPPY 3063
            +   K L+FVTG S+ PL GF+ L+    + R  +       DRLP+S TC N L LP Y
Sbjct: 3982 EELAKLLQFVTGTSKVPLNGFKELEGMNGVSRFNIHRDYGSKDRLPSSHTCFNQLDLPEY 4041

Query: 3064 RTKEQLQTKLLYAINSEAGF 3123
               E L+++LL AI + + +
Sbjct: 4042 ENYETLRSQLLKAITAGSDY 4061

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>O13834:PTR1_SCHPO E3 ubiquitin-protein ligase ptr1 - Schizosaccharomyces pombe (Fission|
            yeast)
          Length = 3227

 Score =  202 bits (513), Expect = 1e-50
 Identities = 118/354 (33%), Positives = 195/354 (55%), Gaps = 3/354 (0%)
 Frame = +1

Query: 2056 IRRSRLLEDAFDQLSLLSEEDLKGPIRVSFVNEHGVEEAGIDGGGIFKDFMENITRAAFD 2235
            +RR  +  D++  L     +++K     S +N H  +E G+D GG+ +++++ + R  F+
Sbjct: 2874 VRRDHVFLDSYRALHFKDADEVK----FSKLNIHFRDEEGVDAGGVTREWLQVLARQMFN 2929

Query: 2236 VQYGLFKETVDHV--LYPNPGSGLVHEQHLQYFHFLGSLLGKAMYEGILVDLPFATFFLS 2409
              Y LF          +PN  S  V+  HL +F F G ++GKA+Y+G L+D  F+     
Sbjct: 2930 PDYALFLPVTGDATTFHPNRDSS-VNPDHLSFFKFTGRIIGKALYDGRLLDCHFSRAVYK 2988

Query: 2410 KLKEKSNFLNDLPSLDPELYRHLLFLKHYKGDVSDLELY-FVIVNNEYGEQAEEELLPGG 2586
             +  +S  + D+ SLDP+ Y+ L+++ +   D++D+    F +  + +GE+   +L+P G
Sbjct: 2989 HMLHRSVSVKDIESLDPDYYKSLVWMLN--NDITDIITEEFAVEKDVFGEKTVVDLIPNG 3046

Query: 2587 REMRVTNQNVITFIHLVANHRLNYQIRGQGRHFLRGFQKLIPKEWIDMFNEHEIQLLISG 2766
            R + VT  N   +++ + +++L   ++ Q +  L GF  +IP   I +FNE E++LLISG
Sbjct: 3047 RNIPVTELNKQNYVNRMVDYKLRESVKDQLKSLLDGFSDIIPSHLIQIFNEQELELLISG 3106

Query: 2767 SLESLDIDDLRLNTNYSGGYHPDHEIIDMLWEVLKSFSSDNQKKFLKFVTGCSRGPLLGF 2946
             L  +DIDD + NT Y G Y+     +   W  ++SF  + + K L+F TG S+ PL GF
Sbjct: 3107 -LPEIDIDDWKNNTEYHG-YNVSSPQVQWFWRAVRSFDEEERAKLLQFATGTSKVPLNGF 3164

Query: 2947 EYLDPKFCIQRAGVPGLEEHGDRLPTSATCMNLLKLPPYRTKEQLQTKLLYAIN 3108
            + L+     QR  +       +RLP S TC N L LP Y T EQL++ LL AIN
Sbjct: 3165 KELEGMSGFQRFNIHKSYGSLNRLPQSHTCFNQLDLPEYDTYEQLRSMLLTAIN 3218

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>Q92462:PUB1_SCHPO E3 ubiquitin-protein ligase pub1 - Schizosaccharomyces pombe (Fission|
            yeast)
          Length = 767

 Score =  201 bits (511), Expect = 2e-50
 Identities = 128/388 (32%), Positives = 212/388 (54%), Gaps = 8/388 (2%)
 Frame = +1

Query: 1984 FTSQLANSKQSTASHSALTRHRFKIRRSRLLEDAFDQLSLLSEEDLKGPIRVSFVNEHGV 2163
            F  +L       A H    +   K+RR+ + ED++ ++   S  DLK  + + F  E G 
Sbjct: 393  FRRKLIYFLSQPALHPLPGQCHIKVRRNHIFEDSYAEIMRQSATDLKKRLMIKFDGEDG- 451

Query: 2164 EEAGIDGGGIFKDFMENITRAAFDVQYGLFK-ETVD-HVLYPNPGSGLVHEQHLQYFHFL 2337
                +D GG+ +++   ++   F+  Y LF+  +VD + L  NP SG ++ +HL YF F+
Sbjct: 452  ----LDYGGLSREYFFLLSHEMFNPFYCLFEYSSVDNYTLQINPHSG-INPEHLNYFKFI 506

Query: 2338 GSLLGKAMYEGILVDLPFATFFLSKLKEKSNFLNDLPSLDPELYRHLLFLKHYKGDVSD- 2514
            G ++G A++    VD  F   F   + +K   L D+ S+D E YR L+++     D++  
Sbjct: 507  GRVIGLAIFHRRFVDAFFVVSFYKMILQKKVTLQDMESMDAEYYRSLVWI--LDNDITGV 564

Query: 2515 LELYFVIVNNEYGEQAEEELLPGGREMRVTNQNVITFIHLVANHRLNYQIRGQGRHFLRG 2694
            L+L F + +N +GE    +L P GR + VT +N   ++ LV   R+  +I  Q   F  G
Sbjct: 565  LDLTFSVEDNCFGEVVTIDLKPNGRNIEVTEENKREYVDLVTVWRIQKRIEEQFNAFHEG 624

Query: 2695 FQKLIPKEWIDMFNEHEIQLLISGSLESLDIDDLRLNTNYSGGYHPDHEIIDMLWEVLKS 2874
            F +LIP+E I++F+E E++LLI G +  +D++D + +T+Y   Y  + +II   WE++  
Sbjct: 625  FSELIPQELINVFDERELELLI-GGISEIDMEDWKKHTDYR-SYSENDQIIKWFWELMDE 682

Query: 2875 FSSDNQKKFLKFVTGCSRGPLLGFEYLD-----PKFCIQRAGVPGLEEHGDRLPTSATCM 3039
            +S++ + + L+F TG SR P+ GF+ L       KF I++AG P      ++LP + TC 
Sbjct: 683  WSNEKKSRLLQFTTGTSRIPVNGFKDLQGSDGPRKFTIEKAGEP------NKLPKAHTCF 736

Query: 3040 NLLKLPPYRTKEQLQTKLLYAINSEAGF 3123
            N L LPPY +K+ L  KL  A+    GF
Sbjct: 737  NRLDLPPYTSKKDLDHKLSIAVEETIGF 764

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>Q7TMY8:HUWE1_MOUSE E3 ubiquitin-protein ligase HUWE1 - Mus musculus (Mouse)|
          Length = 4377

 Score =  201 bits (510), Expect = 2e-50
 Identities = 135/394 (34%), Positives = 202/394 (51%), Gaps = 4/394 (1%)
 Frame = +1

Query: 1963 FTIRVKIFTSQLANSKQSTASHSALTRHRFKIRRSRLLEDAFDQLSLLSEEDLKGPIRVS 2142
            F ++ K F  +L    +              +RR  + ED++ +L   S E++K  + + 
Sbjct: 3997 FDVKRKYFRQELERLDEGLRKEDMAVH----VRRDHVFEDSYRELHRKSPEEMKNRLYIV 4052

Query: 2143 FVNEHGVEEAGIDGGGIFKDFMENITRAAFDVQYGLFKETV-DHVLYPNPGSGLVHEQHL 2319
            F  E G      D GG+ +++   I+R  F+  Y LF+ +  D V Y    S   +  HL
Sbjct: 4053 FEGEEGQ-----DAGGLLREWYMIISREMFNPMYALFRTSPGDRVTYTINPSSHCNPNHL 4107

Query: 2320 QYFHFLGSLLGKAMYEGILVDLPFATFFLSKLKEKSNFLNDLPSLDPELYRHLLFLKHYK 2499
             YF F+G ++ KA+Y+  L++  F   F   +  KS    D+ S D   Y+ L++L   +
Sbjct: 4108 SYFKFVGRIVAKAVYDNRLLECYFTRSFYKHILGKSVRYTDMESEDYHFYQGLVYL--LE 4165

Query: 2500 GDVSDL--ELYFVIVNNEYGEQAEEELLPGGREMRVTNQNVITFIHLVANHRLNYQIRGQ 2673
             DVS L  +L F     E+G     +L P G  + VT +N   ++HLV   R+   IR Q
Sbjct: 4166 NDVSTLGYDLTFSTEVQEFGVCEVRDLKPNGANILVTEENKKEYVHLVCQMRMTGAIRKQ 4225

Query: 2674 GRHFLRGFQKLIPKEWIDMFNEHEIQLLISGSLESLDIDDLRLNTNYSGGYHPDHEIIDM 2853
               FL GF ++IPK  I +F E E++LLISG L ++DIDDL+ NT Y   Y  +   I  
Sbjct: 4226 LAAFLEGFYEIIPKRLISIFTEQELELLISG-LPTIDIDDLKSNTEYH-KYQSNSIQIQW 4283

Query: 2854 LWEVLKSFSSDNQKKFLKFVTGCSRGPLLGFEYLDPKFCIQRAGVPGLEEHGDRLPTSAT 3033
             W  L+SF   ++ KFL+FVTG S+ PL GF  L+    IQ+  +   +   DRLP++ T
Sbjct: 4284 FWRALRSFDQADRAKFLQFVTGTSKVPLQGFAALEGMNGIQKFQIHRDDRSTDRLPSAHT 4343

Query: 3034 CMNLLKLPPYRTKEQLQTKLLYAINS-EAGFDLS 3132
            C N L LP Y + E+L+  LL AI     GF L+
Sbjct: 4344 CFNQLDLPAYESFEKLRHMLLLAIQECSEGFGLA 4377

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>Q7Z6Z7:HUWE1_HUMAN E3 ubiquitin-protein ligase HUWE1 - Homo sapiens (Human)|
          Length = 4374

 Score =  201 bits (510), Expect = 2e-50
 Identities = 135/394 (34%), Positives = 202/394 (51%), Gaps = 4/394 (1%)
 Frame = +1

Query: 1963 FTIRVKIFTSQLANSKQSTASHSALTRHRFKIRRSRLLEDAFDQLSLLSEEDLKGPIRVS 2142
            F ++ K F  +L    +              +RR  + ED++ +L   S E++K  + + 
Sbjct: 3994 FDVKRKYFRQELERLDEGLRKEDMAVH----VRRDHVFEDSYRELHRKSPEEMKNRLYIV 4049

Query: 2143 FVNEHGVEEAGIDGGGIFKDFMENITRAAFDVQYGLFKETV-DHVLYPNPGSGLVHEQHL 2319
            F  E G      D GG+ +++   I+R  F+  Y LF+ +  D V Y    S   +  HL
Sbjct: 4050 FEGEEGQ-----DAGGLLREWYMIISREMFNPMYALFRTSPGDRVTYTINPSSHCNPNHL 4104

Query: 2320 QYFHFLGSLLGKAMYEGILVDLPFATFFLSKLKEKSNFLNDLPSLDPELYRHLLFLKHYK 2499
             YF F+G ++ KA+Y+  L++  F   F   +  KS    D+ S D   Y+ L++L   +
Sbjct: 4105 SYFKFVGRIVAKAVYDNRLLECYFTRSFYKHILGKSVRYTDMESEDYHFYQGLVYL--LE 4162

Query: 2500 GDVSDL--ELYFVIVNNEYGEQAEEELLPGGREMRVTNQNVITFIHLVANHRLNYQIRGQ 2673
             DVS L  +L F     E+G     +L P G  + VT +N   ++HLV   R+   IR Q
Sbjct: 4163 NDVSTLGYDLTFSTEVQEFGVCEVRDLKPNGANILVTEENKKEYVHLVCQMRMTGAIRKQ 4222

Query: 2674 GRHFLRGFQKLIPKEWIDMFNEHEIQLLISGSLESLDIDDLRLNTNYSGGYHPDHEIIDM 2853
               FL GF ++IPK  I +F E E++LLISG L ++DIDDL+ NT Y   Y  +   I  
Sbjct: 4223 LAAFLEGFYEIIPKRLISIFTEQELELLISG-LPTIDIDDLKSNTEYH-KYQSNSIQIQW 4280

Query: 2854 LWEVLKSFSSDNQKKFLKFVTGCSRGPLLGFEYLDPKFCIQRAGVPGLEEHGDRLPTSAT 3033
             W  L+SF   ++ KFL+FVTG S+ PL GF  L+    IQ+  +   +   DRLP++ T
Sbjct: 4281 FWRALRSFDQADRAKFLQFVTGTSKVPLQGFAALEGMNGIQKFQIHRDDRSTDRLPSAHT 4340

Query: 3034 CMNLLKLPPYRTKEQLQTKLLYAINS-EAGFDLS 3132
            C N L LP Y + E+L+  LL AI     GF L+
Sbjct: 4341 CFNQLDLPAYESFEKLRHMLLLAIQECSEGFGLA 4374

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>Q756G2:TOM1_ASHGO Probable E3 ubiquitin-protein ligase TOM1 - Ashbya gossypii (Yeast)|
            (Eremothecium gossypii)
          Length = 3258

 Score =  200 bits (509), Expect = 3e-50
 Identities = 145/452 (32%), Positives = 237/452 (52%), Gaps = 20/452 (4%)
 Frame = +1

Query: 1837 LPFTAESDFYSQEATSENFVSQAILGNTRASEIIKLAPFL--APFTIRVKIFTSQLANSK 2010
            L + A+   +++      F +   L     +E+I+  P L   PF++ VK       ++K
Sbjct: 2824 LKYEAKKCDFARTPVENLFFAFTDLHKKLLNEMIRSNPKLMSGPFSLLVKNPKILDFDNK 2883

Query: 2011 QS--TASHSALTRHRFK----IRRSRLLEDAFDQLSLLSEEDLK-GPIRVSFVNEHGVEE 2169
            +   TA   A+T  R K    +RR  +  D++  L   S ED+K   + +SF  E     
Sbjct: 2884 RYYFTAQLRAITHDRPKLSISVRREHVFLDSYRSLFFKSNEDIKISKLEISFKGE----- 2938

Query: 2170 AGIDGGGIFKDFMENITRAAFDVQYGLFKETVDH--VLYPNPGSGLVHEQHLQYFHFLGS 2343
            AG+D GGI +++ + ++R  F+  Y LF           PN  SG ++ +HL +F F+G 
Sbjct: 2939 AGVDAGGITREWYQVLSRQMFNPDYALFIPVASDKTTFRPNRTSG-INPEHLSFFKFIGM 2997

Query: 2344 LLGKAMYEGILVDLPFATFFLSKLKEKSNFLNDLPSLDPELYRHLLFLKHYKGDVSDL-E 2520
            ++GKA+ +   +D  F+      +  K   L D+ SLD + Y+ L+++   + D++D+ E
Sbjct: 2998 IIGKAISDQCFLDCHFSREVYKNILGKPVALKDMESLDLDYYKSLIWI--LENDITDIIE 3055

Query: 2521 LYFVIVNNEYGEQAEEELLPGGREMRVTNQNVITFIHLVANHRLNYQIRGQGRHFLRGFQ 2700
              F +  ++YGE    EL+  G  + VT QN   ++  +  ++L   ++ Q  +FL+GF 
Sbjct: 3056 ETFSVETDDYGEHKVIELIENGAHVAVTEQNKHDYVKKIVEYKLQTSVKDQMENFLQGFY 3115

Query: 2701 KLIPKEWIDMFNEHEIQLLISGSLESLDIDDLRLNTNYSGGYHPDHEIIDMLWEVLKSFS 2880
             +IPK+ I +F+E E++LL+SG L  +D+DD + NT Y   Y P  + I+  W  ++SF 
Sbjct: 3116 AIIPKDLISIFDEQELELLVSG-LPDIDVDDWKNNTIYV-NYTPTCKQINYFWRAVRSFD 3173

Query: 2881 SDNQKKFLKFVTGCSRGPLLGFEYLD-----PKFCIQRAGVPGLEEHG--DRLPTSATCM 3039
             + + K L+FVTG S+ PL GF+ L       KF I R       ++G  DRLP+S TC 
Sbjct: 3174 KEERAKLLQFVTGTSKVPLNGFKELSGVNGISKFSIHR-------DYGSIDRLPSSHTCF 3226

Query: 3040 NLLKLPPYRTKEQLQTKLLYAIN-SEAGFDLS 3132
            N L LP Y + E L+  LL AIN    GF ++
Sbjct: 3227 NQLDLPAYDSYETLRGSLLLAINEGHEGFGIA 3258

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>O00308:WWP2_HUMAN NEDD4-like E3 ubiquitin-protein ligase WWP2 - Homo sapiens (Human)|
          Length = 870

 Score =  194 bits (494), Expect = 2e-48
 Identities = 124/373 (33%), Positives = 194/373 (52%), Gaps = 8/373 (2%)
 Frame = +1

Query: 2029 SALTRH-RFKIRRSRLLEDAFDQLSLLSEEDLKGPIRVSFVNEHGVEEAGIDGGGIFKDF 2205
            +AL  H +  + R  L ED+F Q+  +   DL+   R  ++   G  E G+D GGI +++
Sbjct: 509  NALPSHVKISVSRQTLFEDSFQQIMNMKPYDLR---RRLYIIMRG--EEGLDYGGIAREW 563

Query: 2206 MENITRAAFDVQYGLFKETV--DHVLYPNPGSGLVHEQHLQYFHFLGSLLGKAMYEGILV 2379
               ++    +  Y LF+     ++ L  NP S  ++  HL YF F+G  +  A+Y G  +
Sbjct: 564  FFLLSHEVLNPMYCLFEYAGKNNYCLQINPASS-INPDHLTYFRFIGRFIAMALYHGKFI 622

Query: 2380 DLPFATFFLSKLKEKSNFLNDLPSLDPELYRHLLFLKHYKGDVSDLELYFVIVNNEYGEQ 2559
            D  F   F  ++  K   L DL S+DPE Y  ++++K    +   LELYF+      G+ 
Sbjct: 623  DTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGLELYFIQDMEILGKV 682

Query: 2560 AEEELLPGGREMRVTNQNVITFIHLVANHRLNYQIRGQGRHFLRGFQKLIPKEWIDMFNE 2739
               EL  GG  +RVT +N   +I L+ + R    +  Q + FL GF ++ P EW+  F+E
Sbjct: 683  TTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDE 742

Query: 2740 HEIQLLISGSLESLDIDDLRLNTNYSGGYHPDHEIIDMLWEVLKSFSSDNQKKFLKFVTG 2919
             E++L++ G ++ +D+ D + +T Y   Y  + + I   W+V+K   ++ + + L+FVTG
Sbjct: 743  KELELMLCG-MQEIDMSDWQKSTIYR-HYTKNSKQIQWFWQVVKEMDNEKRIRLLQFVTG 800

Query: 2920 CSRGPLLGFEYL-----DPKFCIQRAGVPGLEEHGDRLPTSATCMNLLKLPPYRTKEQLQ 3084
              R P+ GF  L       KFCI + G          LP S TC N L LPPY++ EQL+
Sbjct: 801  TCRLPVGGFAELIGSNGPQKFCIDKVG------KETWLPRSHTCFNRLDLPPYKSYEQLR 854

Query: 3085 TKLLYAINSEAGF 3123
             KLLYAI    GF
Sbjct: 855  EKLLYAIEETEGF 867

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>Q9DBH0:WWP2_MOUSE NEDD4-like E3 ubiquitin-protein ligase WWP2 - Mus musculus (Mouse)|
          Length = 870

 Score =  194 bits (492), Expect = 3e-48
 Identities = 124/373 (33%), Positives = 192/373 (51%), Gaps = 8/373 (2%)
 Frame = +1

Query: 2029 SALTRH-RFKIRRSRLLEDAFDQLSLLSEEDLKGPIRVSFVNEHGVEEAGIDGGGIFKDF 2205
            +AL  H +  + R  L ED+F Q+  +   DL+   R  ++   G  E G+D GGI +++
Sbjct: 509  NALPSHVKISVSRQTLFEDSFQQIMNMKPYDLR---RRLYIIMRG--EEGLDYGGIAREW 563

Query: 2206 MENITRAAFDVQYGLFKETV--DHVLYPNPGSGLVHEQHLQYFHFLGSLLGKAMYEGILV 2379
               ++    +  Y LF+     ++ L  NP S  ++  HL YF F+G  +  A+Y G  +
Sbjct: 564  FFLLSHEVLNPMYCLFEYAGKNNYCLQINPASS-INPDHLTYFRFIGRFIAMALYHGKFI 622

Query: 2380 DLPFATFFLSKLKEKSNFLNDLPSLDPELYRHLLFLKHYKGDVSDLELYFVIVNNEYGEQ 2559
            D  F   F  ++  K   L DL S+DPE Y  ++++K    +   LEL+F+      G+ 
Sbjct: 623  DTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGLELFFIQDMEILGKV 682

Query: 2560 AEEELLPGGREMRVTNQNVITFIHLVANHRLNYQIRGQGRHFLRGFQKLIPKEWIDMFNE 2739
               EL  GG  +RVT +N   +I L+ + R    +  Q + FL GF ++ P EW+  F+E
Sbjct: 683  TTHELKEGGENIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDE 742

Query: 2740 HEIQLLISGSLESLDIDDLRLNTNYSGGYHPDHEIIDMLWEVLKSFSSDNQKKFLKFVTG 2919
             E++L++ G ++ +D+ D + N  Y   Y    + I   W+V+K   ++ + + L+FVTG
Sbjct: 743  KELELMLCG-MQEIDMSDWQKNAIYR-HYTKSSKQIQWFWQVVKEMDNEKRIRLLQFVTG 800

Query: 2920 CSRGPLLGFEYL-----DPKFCIQRAGVPGLEEHGDRLPTSATCMNLLKLPPYRTKEQLQ 3084
              R P+ GF  L       KFCI R G          LP S TC N L LPPY++ EQL+
Sbjct: 801  TCRLPVGGFAELIGSNGPQKFCIDRVG------KETWLPRSHTCFNRLDLPPYKSYEQLK 854

Query: 3085 TKLLYAINSEAGF 3123
             KLLYAI    GF
Sbjct: 855  EKLLYAIEETEGF 867

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>Q28BK1:HACE1_XENTR E3 ubiquitin-protein ligase HACE1 - Xenopus tropicalis (Western|
            clawed frog) (Silurana tropicalis)
          Length = 912

 Score =  192 bits (489), Expect = 6e-48
 Identities = 126/400 (31%), Positives = 200/400 (50%), Gaps = 4/400 (1%)
 Frame = +1

Query: 1960 PFTIRVKIFTSQL-ANSKQSTASHSALTRHRFK-IRRSRLLEDAFDQLSLLSEEDLKGPI 2133
            PF  R + F   L A    S   H  +  +    + R  +   + + +   + E LK  I
Sbjct: 526  PFKERCEWFYEHLLAGQPDSDMVHRPVNENDILLVHRDSIFRSSCEVVFKSNCEKLKQGI 585

Query: 2134 RVSFVNEHGVEEAGIDGGGIFKDFMENITRAAFDVQYGLFKETVDHVLYPNPGSGLVHEQ 2313
             V F  E G+      G G+ +++ + ++    +  Y LF ++ D   +    +  V+  
Sbjct: 586  AVRFHGEEGM------GQGVVREWFDILSSEIINPDYALFTQSADGTTFQPNSNSSVNPD 639

Query: 2314 HLQYFHFLGSLLGKAMYEGILVDLPFATFFLSKLKEKSNFLNDLPSLDPELYRHLLFLKH 2493
            HL YF F G +LG A+Y   LV++ F   F   +        D+ S+DPE  ++L ++  
Sbjct: 640  HLNYFRFAGEILGLALYHRQLVNIYFTRSFYKHILGIPVNYQDVASIDPEYAKNLQWI-- 697

Query: 2494 YKGDVSDL--ELYFVIVNNEYGEQAEEELLPGGREMRVTNQNVITFIHLVANHRLNYQIR 2667
               D+SDL  EL F +  + +G   E  L PGG  + VT +N   ++ LV   R+   I+
Sbjct: 698  LDNDISDLGLELTFSVETDVFGAMEEVPLKPGGASILVTQENKAEYVQLVTELRMTRAIQ 757

Query: 2668 GQGRHFLRGFQKLIPKEWIDMFNEHEIQLLISGSLESLDIDDLRLNTNYSGGYHPDHEII 2847
             Q   FL+GF   IP   I +F+E+E++LL+SG  E +D++D   NT Y+ GY  D ++I
Sbjct: 758  PQINGFLQGFHMFIPPSLIQLFDEYELELLLSGMPE-IDVNDWMKNTEYTSGYERDDQVI 816

Query: 2848 DMLWEVLKSFSSDNQKKFLKFVTGCSRGPLLGFEYLDPKFCIQRAGVPGLEEHGDRLPTS 3027
               WEV++  + + +   L+FVTG SR P  GF Y+     +Q   +  +    + LPTS
Sbjct: 817  QWFWEVVQELTQEERVLLLQFVTGSSRVPHGGFAYIMGGSGLQNFTIAAVAYTPNLLPTS 876

Query: 3028 ATCMNLLKLPPYRTKEQLQTKLLYAINSEAGFDLS*LHCG 3147
            +TC+N+LKLP Y +KE L+ +LL A           LHCG
Sbjct: 877  STCINMLKLPEYPSKEILKDRLLVA-----------LHCG 905

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>Q6DCL5:HACE1_XENLA E3 ubiquitin-protein ligase HACE1 - Xenopus laevis (African clawed|
            frog)
          Length = 944

 Score =  192 bits (489), Expect = 6e-48
 Identities = 117/347 (33%), Positives = 182/347 (52%), Gaps = 2/347 (0%)
 Frame = +1

Query: 2113 EDLKGPIRVSFVNEHGVEEAGIDGGGIFKDFMENITRAAFDVQYGLFKETVDHVLYPNPG 2292
            E LK  I V F  E G+      G G+ +++ + ++    +  Y LF ++ D   +    
Sbjct: 611  EKLKQGIAVRFHGEEGM------GQGVVREWFDILSSEMINPDYALFTQSADGTTFQPNS 664

Query: 2293 SGLVHEQHLQYFHFLGSLLGKAMYEGILVDLPFATFFLSKLKEKSNFLNDLPSLDPELYR 2472
            +  V+  HL YF F G +LG A+Y   LV++ F   F   +        D+ S+DPE  +
Sbjct: 665  NSSVNPDHLNYFRFAGEILGLALYHRQLVNIYFTRSFYKHILGIPVNYQDVASIDPEYAK 724

Query: 2473 HLLFLKHYKGDVSDL--ELYFVIVNNEYGEQAEEELLPGGREMRVTNQNVITFIHLVANH 2646
            +L ++     D+SDL  EL F +  + +G   E  L PGG  + VT +N   ++ LV   
Sbjct: 725  NLQWI--LDNDISDLGLELTFSVETDVFGAMEEVPLKPGGASILVTQENKAEYVQLVTEL 782

Query: 2647 RLNYQIRGQGRHFLRGFQKLIPKEWIDMFNEHEIQLLISGSLESLDIDDLRLNTNYSGGY 2826
            R+   I+ Q   FL+GF   IP   I +F+E+E++LL+SG  E +D++D   NT Y+ GY
Sbjct: 783  RMTRAIQPQINGFLQGFHMFIPPSLIQLFDEYELELLLSGMPE-IDVNDWMKNTEYTSGY 841

Query: 2827 HPDHEIIDMLWEVLKSFSSDNQKKFLKFVTGCSRGPLLGFEYLDPKFCIQRAGVPGLEEH 3006
              D ++I   WEV++  + + +   L+FVTG SR P  GF Y+     +Q   +  +   
Sbjct: 842  ERDDQVIQWFWEVVQELTQEERVLLLQFVTGSSRVPHGGFAYIMGGSGLQNFTIAAVAYT 901

Query: 3007 GDRLPTSATCMNLLKLPPYRTKEQLQTKLLYAINSEAGFDLS*LHCG 3147
             + LPTS+TC+N+LKLP Y +KE L+ +LL A           LHCG
Sbjct: 902  ANLLPTSSTCINMLKLPEYPSKEILKDRLLVA-----------LHCG 937

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>Q96J02:ITCH_HUMAN E3 ubiquitin-protein ligase Itchy homolog - Homo sapiens (Human)|
          Length = 903

 Score =  192 bits (488), Expect = 8e-48
 Identities = 117/372 (31%), Positives = 198/372 (53%), Gaps = 8/372 (2%)
 Frame = +1

Query: 2032 ALTRH-RFKIRRSRLLEDAFDQLSLLSEEDLKGPIRVSFVNEHGVEEAGIDGGGIFKDFM 2208
            A+ +H +  + R  L ED+F Q+   S +DL+  + V F  E G     +D GG+ +++ 
Sbjct: 543  AMPQHIKITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIFPGEEG-----LDYGGVAREWF 597

Query: 2209 ENITRAAFDVQYGLFKETV--DHVLYPNPGSGLVHEQHLQYFHFLGSLLGKAMYEGILVD 2382
              ++    +  Y LF+     ++ L  NP S  ++  HL+YF F+G  +  A++ G  +D
Sbjct: 598  FLLSHEVLNPMYCLFEYAGKDNYCLQINPAS-YINPDHLKYFRFIGRFIAMALFHGKFID 656

Query: 2383 LPFATFFLSKLKEKSNFLNDLPSLDPELYRHLLFLKHYKGDVSDLELYFVIVNNEYGEQA 2562
              F+  F  ++  K   L DL S+DPE Y  L+++K    +  DLE+YF +     GE  
Sbjct: 657  TGFSLPFYKRILNKPVGLKDLESIDPEFYNSLIWVKENNIEECDLEMYFSVDKEILGEIK 716

Query: 2563 EEELLPGGREMRVTNQNVITFIHLVANHRLNYQIRGQGRHFLRGFQKLIPKEWIDMFNEH 2742
              +L P G  + VT +N   +I +VA  RL+  +  Q + F  GF +++P++++  F+  
Sbjct: 717  SHDLKPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAK 776

Query: 2743 EIQLLISGSLESLDIDDLRLNTNYSGGYHPDHEIIDMLWEVLKSFSSDNQKKFLKFVTGC 2922
            E+++L+ G ++ +D++D + +  Y   Y    + I   W+ +K   ++ + + L+FVTG 
Sbjct: 777  ELEVLLCG-MQEIDLNDWQRHAIYR-HYARTSKQIMWFWQFVKEIDNEKRMRLLQFVTGT 834

Query: 2923 SRGPLLGFEYL-----DPKFCIQRAGVPGLEEHGDRLPTSATCMNLLKLPPYRTKEQLQT 3087
             R P+ GF  L       KFCI++ G        + LP S TC N L LPPY++ EQL+ 
Sbjct: 835  CRLPVGGFADLMGSNGPQKFCIEKVG------KENWLPRSHTCFNRLDLPPYKSYEQLKE 888

Query: 3088 KLLYAINSEAGF 3123
            KLL+AI    GF
Sbjct: 889  KLLFAIEETEGF 900

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>Q9UTG2:PUB2_SCHPO E3 ubiquitin-protein ligase pub2 - Schizosaccharomyces pombe (Fission|
            yeast)
          Length = 671

 Score =  190 bits (483), Expect = 3e-47
 Identities = 120/366 (32%), Positives = 191/366 (52%), Gaps = 7/366 (1%)
 Frame = +1

Query: 2047 RFKIRRSRLLEDAFDQLSLLSEEDLKGPIRVSFVNEHGVEEAGIDGGGIFKDFMENITRA 2226
            + K+ R+   EDA+D +S LS  D+K  + + F NE G     +D GG+ ++F   ++ A
Sbjct: 318  QLKVSRATTFEDAYDIISKLSVSDMKKKLLIRFRNEDG-----LDYGGVSREFFYILSHA 372

Query: 2227 AFDVQYGLFKETVD--HVLYPNPGSGLVHEQHLQYFHFLGSLLGKAMYEGILVDLPFATF 2400
             F+  Y LF+   D  + L  +P S  V+     YF F+G ++G A+Y    +D+ F   
Sbjct: 373  IFNPGYSLFEYATDDNYGLQISPLSS-VNPDFRSYFRFVGRVMGLAIYHRRYLDVQFVLP 431

Query: 2401 FLSKLKEKSNFLNDLPSLDPELYRHLLFLKHYKGDVSDLELYFVIVNNEYGEQAEEELLP 2580
            F  ++ +K   L D+  +D   Y  L ++K+   D S L L F +  N +GE    +L+P
Sbjct: 432  FYKRILQKPLCLEDVKDVDEVYYESLKWIKNNDVDES-LCLNFSVEENRFGESVTVDLIP 490

Query: 2581 GGREMRVTNQNVITFIHLVANHRLNYQIRGQGRHFLRGFQKLIPKEWIDMFNEHEIQLLI 2760
             GR + V NQN + ++  +  H+L      Q      G  +LIP   + +FNE+E+  L+
Sbjct: 491  NGRNIAVNNQNKMNYLKALTEHKLVTSTEEQFNALKGGLNELIPDSVLQIFNENELDTLL 550

Query: 2761 SGSLESLDIDDLRLNTNYSGGYHPDHEIIDMLWEVLKSFSSDNQKKFLKFVTGCSRGPLL 2940
            +G    +D+ D +  T+Y   Y    +I+   WE+L  +S + + K L+F TG SR PL 
Sbjct: 551  NGK-RDIDVQDWKRFTDYR-SYTETDDIVIWFWELLSEWSPEKKAKLLQFATGTSRLPLS 608

Query: 2941 GFEYL-----DPKFCIQRAGVPGLEEHGDRLPTSATCMNLLKLPPYRTKEQLQTKLLYAI 3105
            GF+ +       KF I++ G      H  +LP + TC N L +PPY +KE+L+ KL  AI
Sbjct: 609  GFKDMHGSDGPRKFTIEKVG------HISQLPKAHTCFNRLDIPPYNSKEELEQKLTIAI 662

Query: 3106 NSEAGF 3123
               AGF
Sbjct: 663  QETAGF 668

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>Q8C863:ITCH_MOUSE E3 ubiquitin-protein ligase Itchy - Mus musculus (Mouse)|
          Length = 864

 Score =  189 bits (481), Expect = 5e-47
 Identities = 116/372 (31%), Positives = 197/372 (52%), Gaps = 8/372 (2%)
 Frame = +1

Query: 2032 ALTRH-RFKIRRSRLLEDAFDQLSLLSEEDLKGPIRVSFVNEHGVEEAGIDGGGIFKDFM 2208
            A+ +H +  + R  L ED+F Q+   S +DL+  + V F  E G     +D GG+ +++ 
Sbjct: 504  AMPQHIKITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIFPGEEG-----LDYGGVAREWF 558

Query: 2209 ENITRAAFDVQYGLFKETV--DHVLYPNPGSGLVHEQHLQYFHFLGSLLGKAMYEGILVD 2382
              ++    +  Y LF+     ++ L  NP S  ++  HL+YF F+G  +  A++ G  +D
Sbjct: 559  FLLSHEVLNPMYCLFEYAGKDNYCLQINPAS-YINPDHLKYFRFIGRFIAMALFHGKFID 617

Query: 2383 LPFATFFLSKLKEKSNFLNDLPSLDPELYRHLLFLKHYKGDVSDLELYFVIVNNEYGEQA 2562
              F+  F  ++  K   L DL S+DPE Y  L+++K    +   LE+YF +     GE  
Sbjct: 618  TGFSLPFYKRILNKPVGLKDLESIDPEFYNSLIWVKENNIEECGLEMYFSVDKEILGEIK 677

Query: 2563 EEELLPGGREMRVTNQNVITFIHLVANHRLNYQIRGQGRHFLRGFQKLIPKEWIDMFNEH 2742
              +L P G  + VT +N   +I +VA  RL+  +  Q + F  GF +++P++++  F+  
Sbjct: 678  SHDLKPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAK 737

Query: 2743 EIQLLISGSLESLDIDDLRLNTNYSGGYHPDHEIIDMLWEVLKSFSSDNQKKFLKFVTGC 2922
            E+++L+ G ++ +D++D + +  Y   Y    + I   W+ +K   ++ + + L+FVTG 
Sbjct: 738  ELEVLLCG-MQEIDLNDWQRHAIYR-HYTRTSKQIMWFWQFVKEIDNEKRMRLLQFVTGT 795

Query: 2923 SRGPLLGFEYL-----DPKFCIQRAGVPGLEEHGDRLPTSATCMNLLKLPPYRTKEQLQT 3087
             R P+ GF  L       KFCI++ G        + LP S TC N L LPPY++ EQL+ 
Sbjct: 796  CRLPVGGFADLMGSNGPQKFCIEKVG------KENWLPRSHTCFNRLDLPPYKSYEQLKE 849

Query: 3088 KLLYAINSEAGF 3123
            KLL+AI    GF
Sbjct: 850  KLLFAIEETEGF 861

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>Q03280:TOM1_YEAST E3 ubiquitin-protein ligase TOM1 - Saccharomyces cerevisiae (Baker's|
            yeast)
          Length = 3268

 Score =  188 bits (478), Expect = 1e-46
 Identities = 115/364 (31%), Positives = 201/364 (55%), Gaps = 5/364 (1%)
 Frame = +1

Query: 2056 IRRSRLLEDAFDQLSLLSEEDLKGP-IRVSFVNEHGVEEAGIDGGGIFKDFMENITRAAF 2232
            +RR ++  D++  L   + +++K   + ++F  E     +G+D GG+ +++ + ++R  F
Sbjct: 2915 VRREQVFLDSYRALFFKTNDEIKNSKLEITFKGE-----SGVDAGGVTREWYQVLSRQMF 2969

Query: 2233 DVQYGLFKETVDH--VLYPNPGSGLVHEQHLQYFHFLGSLLGKAMYEGILVDLPFATFFL 2406
            +  Y LF          +PN  SG ++ +HL +F F+G ++GKA+ +   +D  F+    
Sbjct: 2970 NPDYALFLPVPSDKTTFHPNRTSG-INPEHLSFFKFIGMIIGKAIRDQCFLDCHFSREVY 3028

Query: 2407 SKLKEKSNFLNDLPSLDPELYRHLLFLKHYKGDVSDL-ELYFVIVNNEYGEQAEEELLPG 2583
              +  +   L D+ SLDP+ Y+ L+++   + D++D+ E  F +  ++YGE     L+ G
Sbjct: 3029 KNILGRPVSLKDMESLDPDYYKSLVWI--LENDITDIIEETFSVETDDYGEHKVINLIEG 3086

Query: 2584 GREMRVTNQNVITFIHLVANHRLNYQIRGQGRHFLRGFQKLIPKEWIDMFNEHEIQLLIS 2763
            G+++ VT  N   ++  V  ++L   ++ Q  +FL GF  LI K+ I +F+E E++LLIS
Sbjct: 3087 GKDIIVTEANKQDYVKKVVEYKLQTSVKEQMDNFLVGFYALISKDLITIFDEQELELLIS 3146

Query: 2764 GSLESLDIDDLRLNTNYSGGYHPDHEIIDMLWEVLKSFSSDNQKKFLKFVTGCSRGPLLG 2943
            G L  +D+DD + NT Y   Y    + +   W  ++SF ++ + K L+FVTG S+ PL G
Sbjct: 3147 G-LPDIDVDDWKNNTTYV-NYTATCKEVSYFWRAVRSFDAEERAKLLQFVTGTSKVPLNG 3204

Query: 2944 FEYLDPKFCIQRAGVPGLEEHGDRLPTSATCMNLLKLPPYRTKEQLQTKLLYAIN-SEAG 3120
            F+ L     + +  +       +RLP+S TC N L LPPY + E L+  LL AIN    G
Sbjct: 3205 FKELSGVNGVCKFSIHRDFGSSERLPSSHTCFNQLNLPPYESYETLRGSLLLAINEGHEG 3264

Query: 3121 FDLS 3132
            F L+
Sbjct: 3265 FGLA 3268

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>Q9PUN2:SMUF1_XENLA E3 ubiquitin-protein ligase SMURF1 - Xenopus laevis (African clawed|
            frog)
          Length = 731

 Score =  188 bits (478), Expect = 1e-46
 Identities = 113/370 (30%), Positives = 198/370 (53%), Gaps = 11/370 (2%)
 Frame = +1

Query: 2047 RFKIRRSRLLEDAFDQLSLLSEEDLKGPIRVSFVNEHGVEEAGIDGGGIFKDFMENITRA 2226
            R ++ R  + E+++ Q+  +  +DLK  + V F  E G     +D GG+ ++++  +   
Sbjct: 374  RVEVSREEIFEESYRQIMKMRPKDLKKRLMVKFRGEEG-----LDYGGVAREWLYLLCHE 428

Query: 2227 AFDVQYGLFKETVDHV--LYPNPGSGLVHEQHLQYFHFLGSLLGKAMYEGILVDLPFATF 2400
              +  YGLF+ + D++  L  NP S  ++  HL YFHF+G ++G A++ G  ++  F   
Sbjct: 429  MLNPYYGLFQYSTDNIYTLQINPDSS-INPDHLSYFHFVGRIMGLAVFHGHYINGGFTVP 487

Query: 2401 FLSKLKEKSNFLNDLPSLDPELYRHLLFLKHYKGDVSD-LELYFVIVNNEYGEQAEEELL 2577
            F  +L  K   L+DL S+DPEL++ L+++   + D++  L+  F + +N +G   + EL 
Sbjct: 488  FYKQLLGKPIQLSDLESVDPELHKSLVWI--LENDITSVLDHTFCVEHNAFGRLLQHELK 545

Query: 2578 PGGREMRVTNQNVITFIHLVANHRLNYQIRGQGRHFLRGFQKLIPKEWIDMFNEHEIQLL 2757
            P G+ ++VT +N   ++ L  N R    I  Q     +GF +LIP+  +  F + E++L+
Sbjct: 546  PNGKNLQVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFEQKELELI 605

Query: 2758 ISGSLESLDIDDLRLNTNYSGGYHPDHEIIDMLWEVLKSFSSDNQKKFLKFVTGCSRGPL 2937
            I G L+ +DI D + NT        +  I+   W+ ++SF  + + + L+FVTG +R PL
Sbjct: 606  I-GGLDKIDISDWKANTRLKHCL-ANSNIVQWFWQAVESFDEERRARLLQFVTGSTRVPL 663

Query: 2938 LGFEYLDPKFCIQRAGVPG--------LEEHGDRLPTSATCMNLLKLPPYRTKEQLQTKL 3093
             GF+ L         G  G        ++ + D LP + TC N + +PPY + E+L  KL
Sbjct: 664  QGFKALQGS-----TGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKL 718

Query: 3094 LYAINSEAGF 3123
            L A+   +GF
Sbjct: 719  LTAVEETSGF 728

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>Q9HAU4:SMUF2_HUMAN E3 ubiquitin-protein ligase SMURF2 - Homo sapiens (Human)|
          Length = 748

 Score =  187 bits (476), Expect = 2e-46
 Identities = 117/387 (30%), Positives = 207/387 (53%), Gaps = 3/387 (0%)
 Frame = +1

Query: 1972 RVKIFTSQLANSKQSTASHSALTRHRFKIRRSRLLEDAFDQLSLLSEEDLKGPIRVSFVN 2151
            ++KI   +L+  +Q  A H      R ++ R  + E+++ Q+  +  +DL   + + F  
Sbjct: 375  KLKILRQELSQ-QQPQAGHC-----RIEVSREEIFEESYRQVMKMRPKDLWKRLMIKFRG 428

Query: 2152 EHGVEEAGIDGGGIFKDFMENITRAAFDVQYGLFKETVDHV--LYPNPGSGLVHEQHLQY 2325
            E G     +D GG+ ++++  ++    +  YGLF+ + D +  L  NP S  V+ +HL Y
Sbjct: 429  EEG-----LDYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSA-VNPEHLSY 482

Query: 2326 FHFLGSLLGKAMYEGILVDLPFATFFLSKLKEKSNFLNDLPSLDPELYRHLLFLKHYKGD 2505
            FHF+G ++G A++ G  +D  F   F  +L  KS  L+D+  +DP+L+  L+++   + D
Sbjct: 483  FHFVGRIMGMAVFHGHYIDGGFTLPFYKQLLGKSITLDDMELVDPDLHNSLVWI--LEND 540

Query: 2506 VSD-LELYFVIVNNEYGEQAEEELLPGGREMRVTNQNVITFIHLVANHRLNYQIRGQGRH 2682
            ++  L+  F + +N YGE  + EL P G+ + V  +N   ++ L  N R    I  Q   
Sbjct: 541  ITGVLDHTFCVEHNAYGEIIQHELKPNGKSIPVNEENKKEYVRLYVNWRFLRGIEAQFLA 600

Query: 2683 FLRGFQKLIPKEWIDMFNEHEIQLLISGSLESLDIDDLRLNTNYSGGYHPDHEIIDMLWE 2862
              +GF ++IP+  +  F+E E++L+I G L  +D++D ++NT       PD  I+   W+
Sbjct: 601  LQKGFNEVIPQHLLKTFDEKELELIICG-LGKIDVNDWKVNTRLK-HCTPDSNIVKWFWK 658

Query: 2863 VLKSFSSDNQKKFLKFVTGCSRGPLLGFEYLDPKFCIQRAGVPGLEEHGDRLPTSATCMN 3042
             ++ F  + + + L+FVTG SR PL GF+ L      +   +  ++   + LP + TC N
Sbjct: 659  AVEFFDEERRARLLQFVTGSSRVPLQGFKALQGAAGPRLFTIHQIDACTNNLPKAHTCFN 718

Query: 3043 LLKLPPYRTKEQLQTKLLYAINSEAGF 3123
             + +PPY + E+L  KLL AI    GF
Sbjct: 719  RIDIPPYESYEKLYEKLLTAIEETCGF 745

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>Q9V853:SMUF1_DROME E3 ubiquitin-protein ligase Smurf1 - Drosophila melanogaster (Fruit|
            fly)
          Length = 1061

 Score =  187 bits (476), Expect = 2e-46
 Identities = 125/373 (33%), Positives = 198/373 (53%), Gaps = 14/373 (3%)
 Frame = +1

Query: 2047 RFKIRRSRLLEDAFDQLSLLSEEDLKGPIRVSFVNEHGVEEAGIDGGGIFKDFMENITRA 2226
            R ++ R+ + E+++  +  +  +D++  + V F  E G     +D GG+ ++++  ++R 
Sbjct: 703  RLEVSRNEIFEESYRLIMKMRAKDMRKRLMVKFKGEEG-----LDYGGVAREWLHLLSRE 757

Query: 2227 AFDVQYGLFKETVD--HVLYPNPGSGLVHEQHLQYFHFLGSLLGKAMYEGILVDLPFATF 2400
              + QYGLF+ + D  + L  NP SG V+  HL YFHF+G  LG A++ G  +D  F T 
Sbjct: 758  MLNPQYGLFQYSRDDHYTLQINPDSG-VNPDHLSYFHFVGRTLGIAVFHGHCLDGGFTTP 816

Query: 2401 FLSKLKEKSNFLNDLPSLDPELYRHLLFLKHYKGDVSDL-ELYFVIVNNEYGEQAEEELL 2577
            F  +L  K   L D+  +DP+L+R L ++   + ++S + E  F + NN +G     EL 
Sbjct: 817  FYKQLLNKPITLGDIEGVDPDLHRSLTWM--LESNISGIIESTFSVENNSFGALVVHELK 874

Query: 2578 PGGREMRVTNQNVITFIHLVANHRLNYQIRGQGRHFLRGFQKLIPKEWIDMFNEHEIQLL 2757
            PGG  + VT +N   ++ L  N+R    I  Q     +GF +LIP   +  F+E E++L+
Sbjct: 875  PGGASIPVTEENKREYVKLYVNYRFMRGIEQQFLALQKGFCELIPSHLLRPFDERELELV 934

Query: 2758 ISGSLESLDIDDLRLNTNYSGGYHPDHEIIDML--WEVLKSFSSDNQKKFLKFVTGCSRG 2931
            I G + S+D++D R NT      H  +E   +L  W+V++S+SS+ + + L+FVTG SR 
Sbjct: 935  I-GGISSIDVNDWRNNTRLK---HCTNETTQVLWFWQVVESYSSEMRARLLQFVTGSSRV 990

Query: 2932 PLLGFEYLDPK--------FCIQ-RAGVPGLEEHGDRLPTSATCMNLLKLPPYRTKEQLQ 3084
            PL GF  L           F I   A VP        LP + TC N + LPPY T + L 
Sbjct: 991  PLQGFRALQGSTGAVGPRLFTIHLTADVP-----TQNLPKAHTCFNRIDLPPYETYQLLC 1045

Query: 3085 TKLLYAINSEAGF 3123
             KL  A+    GF
Sbjct: 1046 DKLTQAVEETCGF 1058

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>O14326:PUB3_SCHPO E3 ubiquitin-protein ligase pub3 - Schizosaccharomyces pombe (Fission|
            yeast)
          Length = 786

 Score =  187 bits (476), Expect = 2e-46
 Identities = 115/365 (31%), Positives = 195/365 (53%), Gaps = 8/365 (2%)
 Frame = +1

Query: 2053 KIRRSRLLEDAFDQLSLLSEEDLKGPIRVSFVNEHGVEEAGIDGGGIFKDFMENITRAAF 2232
            K+RR  + ED++ ++   S  DLK  + + F  E G     +D GG+ ++F   ++   F
Sbjct: 435  KVRRDHIFEDSYAEIMRYSAHDLKKRLMIRFDGEDG-----LDYGGLSREFFFLLSHKMF 489

Query: 2233 DVQYGLFKETV--DHVLYPNPGSGLVHEQHLQYFHFLGSLLGKAMYEGILVDLPFATFFL 2406
            D  Y LF+ +   ++ L  NP S  ++ +HL YF F+G ++G A++    +D  F     
Sbjct: 490  DPIYCLFEYSAVDNYTLQINPHSS-INPEHLNYFRFIGRVIGLAIFHRRFLDAFFVVSLY 548

Query: 2407 SKLKEKSNFLNDLPSLDPELYRHLLFLKHYKGDVSD-LELYFVIVNNEYGEQAEEELLPG 2583
             KL  K   L D+ S+D E YR L ++   + D++  L+L F +  + +GE    EL+  
Sbjct: 549  KKLLRKKVSLADMESIDAEFYRSLKWV--LENDITGILDLTFSVEEDHFGEVRTVELITN 606

Query: 2584 GREMRVTNQNVITFIHLVANHRLNYQIRGQGRHFLRGFQKLIPKEWIDMFNEHEIQLLIS 2763
            G  + VT +N   ++ LV   R++ ++  Q   F  GF +L+  + +++F+E E++LLI 
Sbjct: 607  GENIEVTEENKKKYVDLVTEWRVSKRVEQQFNAFYSGFVELVSPDLVNVFDERELELLI- 665

Query: 2764 GSLESLDIDDLRLNTNYSGGYHPDHEIIDMLWEVLKSFSSDNQKKFLKFVTGCSRGPLLG 2943
            G +  +D++D + +T Y   Y     +I   WE++  + ++++ K L+F TG SR P+ G
Sbjct: 666  GGISDVDVEDWKSHTEYR-TYIATDPVIKWFWEIIAGWKNEDRSKLLQFATGTSRIPVNG 724

Query: 2944 FEYLD-----PKFCIQRAGVPGLEEHGDRLPTSATCMNLLKLPPYRTKEQLQTKLLYAIN 3108
            F  L       KF I++AG P      D+LP + TC N L LP Y +K+ L  KL  A+ 
Sbjct: 725  FRDLQGSDGPRKFTIEKAGTP------DQLPVAHTCFNRLDLPDYPSKDTLHEKLSLAVE 778

Query: 3109 SEAGF 3123
            +  GF
Sbjct: 779  NTVGF 783

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>Q9CUN6:SMUF1_MOUSE E3 ubiquitin-protein ligase SMURF1 - Mus musculus (Mouse)|
          Length = 731

 Score =  187 bits (475), Expect = 3e-46
 Identities = 118/395 (29%), Positives = 209/395 (52%), Gaps = 11/395 (2%)
 Frame = +1

Query: 1972 RVKIFTSQLANSKQSTASHSALTRHRFKIRRSRLLEDAFDQLSLLSEEDLKGPIRVSFVN 2151
            ++K+   +L+  +Q  A H      R ++ R  + E+++ Q+  +  +DLK  + V F  
Sbjct: 355  KLKVLRHELS-LQQPQAGHC-----RIEVSREEIFEESYRQIMKMRPKDLKKRLMVKFRG 408

Query: 2152 EHGVEEAGIDGGGIFKDFMENITRAAFDVQYGLFKETVDHV--LYPNPGSGLVHEQHLQY 2325
            E G     +D GG+ ++++  +     +  YGLF+ + D++  L  NP S  ++  HL Y
Sbjct: 409  EEG-----LDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYTLQINPDSS-INPDHLSY 462

Query: 2326 FHFLGSLLGKAMYEGILVDLPFATFFLSKLKEKSNFLNDLPSLDPELYRHLLFLKHYKGD 2505
            FHF+G ++G A++ G  ++  F   F  +L  K   L+DL S+DPEL++ L+++   + D
Sbjct: 463  FHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWI--LEND 520

Query: 2506 VSD-LELYFVIVNNEYGEQAEEELLPGGREMRVTNQNVITFIHLVANHRLNYQIRGQGRH 2682
            ++  L+  F + +N +G   + EL P GR + VT +N   ++ L  N R    I  Q   
Sbjct: 521  ITPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLA 580

Query: 2683 FLRGFQKLIPKEWIDMFNEHEIQLLISGSLESLDIDDLRLNTNYSGGYHPDHEIIDMLWE 2862
              +GF +LIP+  +  F++ E++L+I G L+ +D++D + NT        D  I+   W+
Sbjct: 581  LQKGFNELIPQHLLKPFDQKELELII-GGLDKIDLNDWKSNTRLKHCV-ADSNIVRWFWQ 638

Query: 2863 VLKSFSSDNQKKFLKFVTGCSRGPLLGFEYLDPKFCIQRAGVPG--------LEEHGDRL 3018
             +++F  + + + L+FVTG +R PL GF+ L         G  G        ++ + D L
Sbjct: 639  AVETFDEERRARLLQFVTGSTRVPLQGFKALQGS-----TGAAGPRLFTIHLIDANTDNL 693

Query: 3019 PTSATCMNLLKLPPYRTKEQLQTKLLYAINSEAGF 3123
            P + TC N + +PPY + E+L  KLL A+    GF
Sbjct: 694  PKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGF 728

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>Q9HCE7:SMUF1_HUMAN E3 ubiquitin-protein ligase SMURF1 - Homo sapiens (Human)|
          Length = 757

 Score =  187 bits (475), Expect = 3e-46
 Identities = 118/395 (29%), Positives = 209/395 (52%), Gaps = 11/395 (2%)
 Frame = +1

Query: 1972 RVKIFTSQLANSKQSTASHSALTRHRFKIRRSRLLEDAFDQLSLLSEEDLKGPIRVSFVN 2151
            ++K+   +L+  +Q  A H      R ++ R  + E+++ Q+  +  +DLK  + V F  
Sbjct: 381  KLKVLRHELS-LQQPQAGHC-----RIEVSREEIFEESYRQIMKMRPKDLKKRLMVKFRG 434

Query: 2152 EHGVEEAGIDGGGIFKDFMENITRAAFDVQYGLFKETVDHV--LYPNPGSGLVHEQHLQY 2325
            E G     +D GG+ ++++  +     +  YGLF+ + D++  L  NP S  ++  HL Y
Sbjct: 435  EEG-----LDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSS-INPDHLSY 488

Query: 2326 FHFLGSLLGKAMYEGILVDLPFATFFLSKLKEKSNFLNDLPSLDPELYRHLLFLKHYKGD 2505
            FHF+G ++G A++ G  ++  F   F  +L  K   L+DL S+DPEL++ L+++   + D
Sbjct: 489  FHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWI--LEND 546

Query: 2506 VSD-LELYFVIVNNEYGEQAEEELLPGGREMRVTNQNVITFIHLVANHRLNYQIRGQGRH 2682
            ++  L+  F + +N +G   + EL P GR + VT +N   ++ L  N R    I  Q   
Sbjct: 547  ITPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLA 606

Query: 2683 FLRGFQKLIPKEWIDMFNEHEIQLLISGSLESLDIDDLRLNTNYSGGYHPDHEIIDMLWE 2862
              +GF +LIP+  +  F++ E++L+I G L+ +D++D + NT        D  I+   W+
Sbjct: 607  LQKGFNELIPQHLLKPFDQKELELII-GGLDKIDLNDWKSNTRLKHCV-ADSNIVRWFWQ 664

Query: 2863 VLKSFSSDNQKKFLKFVTGCSRGPLLGFEYLDPKFCIQRAGVPG--------LEEHGDRL 3018
             +++F  + + + L+FVTG +R PL GF+ L         G  G        ++ + D L
Sbjct: 665  AVETFDEERRARLLQFVTGSTRVPLQGFKALQGS-----TGAAGPRLFTIHLIDANTDNL 719

Query: 3019 PTSATCMNLLKLPPYRTKEQLQTKLLYAINSEAGF 3123
            P + TC N + +PPY + E+L  KLL A+    GF
Sbjct: 720  PKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGF 754

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>P51593:HUWE1_RAT E3 ubiquitin-protein ligase HUWE1 - Rattus norvegicus (Rat)|
          Length = 322

 Score =  187 bits (475), Expect = 3e-46
 Identities = 122/326 (37%), Positives = 176/326 (53%), Gaps = 4/326 (1%)
 Frame = +1

Query: 2167 EAGIDGGGIFKDFMENITRAAFDVQYGLFKETV-DHVLYPNPGSGLVHEQHLQYFHFLGS 2343
            E G D GG+ +++   I+R  F+  Y LF+ +  D V Y    S   +  HL YF F+G 
Sbjct: 1    EEGQDAGGLLREWYMIISREMFNPMYALFRTSPGDRVTYTINPSSHCNPNHLSYFKFVGR 60

Query: 2344 LLGKAMYEGILVDLPFATFFLSKLKEKSNFLNDLPSLDPELYRHLLFLKHYKGDVSDL-- 2517
            ++ KA+Y+  L++  F   F   +  KS    D+ S D   Y+ L++L   + DVS L  
Sbjct: 61   IVAKAVYDNRLLECYFTRSFYKHILGKSVRYTDMESEDYHFYQGLVYL--LENDVSTLGY 118

Query: 2518 ELYFVIVNNEYGEQAEEELLPGGREMRVTNQNVITFIHLVANHRLNYQIRGQGRHFLRGF 2697
            +L F     E+G     +L P G  + VT +N   ++HLV   R+   IR Q   FL GF
Sbjct: 119  DLTFSTEVQEFGVCEVRDLKPNGANILVTEENKKEYVHLVCQMRMTGAIRKQLAAFLEGF 178

Query: 2698 QKLIPKEWIDMFNEHEIQLLISGSLESLDIDDLRLNTNYSGGYHPDHEIIDMLWEVLKSF 2877
             ++IPK  I +F E E++LLISG L ++DIDDL+ NT Y   Y  +   I   W  L+SF
Sbjct: 179  YEIIPKRLISIFTEQELELLISG-LPTIDIDDLKSNTEYH-KYQSNSIQIQWFWRALRSF 236

Query: 2878 SSDNQKKFLKFVTGCSRGPLLGFEYLDPKFCIQRAGVPGLEEHGDRLPTSATCMNLLKLP 3057
               ++ KFL+FVTG S+ PL GF  L+    IQ+  +   +   DRLP++ TC N L LP
Sbjct: 237  DQADRAKFLQFVTGTSKVPLQGFAALEGMNGIQKFQIHRDDRSTDRLPSAHTCFNQLDLP 296

Query: 3058 PYRTKEQLQTKLLYAINS-EAGFDLS 3132
             Y + E+L+  LL AI     GF L+
Sbjct: 297  AYESFEKLRHMLLLAIQECSEGFGLA 322

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>Q8BZZ3:WWP1_MOUSE NEDD4-like E3 ubiquitin-protein ligase WWP1 - Mus musculus (Mouse)|
          Length = 918

 Score =  185 bits (470), Expect = 1e-45
 Identities = 117/387 (30%), Positives = 200/387 (51%), Gaps = 7/387 (1%)
 Frame = +1

Query: 1984 FTSQLANSKQSTASHSALTRHRFKIRRSRLLEDAFDQLSLLSEEDLKGPIRVSFVNEHGV 2163
            F  +LA+ +    S++  +  +  + R  L ED+F Q+  L   DL+  + V F  E G 
Sbjct: 543  FRWKLAHFRYLCQSNALPSHVKINVSRQTLFEDSFQQIMALKPYDLRRRLYVIFRGEEG- 601

Query: 2164 EEAGIDGGGIFKDFMENITRAAFDVQYGLFKETV--DHVLYPNPGSGLVHEQHLQYFHFL 2337
                +D GG+ +++   ++    +  Y LF+     ++ L  NP S  ++  HL YF F+
Sbjct: 602  ----LDYGGLAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPAS-TINPDHLSYFCFI 656

Query: 2338 GSLLGKAMYEGILVDLPFATFFLSKLKEKSNFLNDLPSLDPELYRHLLFLKHYKGDVSDL 2517
            G  +  A++ G  +D  F+  F  ++  K   + DL S+D E Y  L++++    +   L
Sbjct: 657  GRFIAMALFHGKFIDTGFSLPFYKRMLSKKLTIKDLESIDTEFYNSLIWIRDNNIEECGL 716

Query: 2518 ELYFVIVNNEYGEQAEEELLPGGREMRVTNQNVITFIHLVANHRLNYQIRGQGRHFLRGF 2697
            E+YF +     G+    +L  GG  + VT +N   +I L+   R +  ++ Q + FL GF
Sbjct: 717  EMYFSVDMEILGKVTSHDLKLGGSNILVTEENKDEYIGLMTEWRFSRGVQEQTKAFLDGF 776

Query: 2698 QKLIPKEWIDMFNEHEIQLLISGSLESLDIDDLRLNTNYSGGYHPDHEIIDMLWEVLKSF 2877
             +++P +W+  F+E E+++++ G ++ +D+ D + NT Y   Y  + + I   W+ +K  
Sbjct: 777  NEVVPLQWLQYFDEKELEVMLCG-MQEVDLADWQRNTVYR-HYTRNSKQIIWFWQFVKET 834

Query: 2878 SSDNQKKFLKFVTGCSRGPLLGFEYL-----DPKFCIQRAGVPGLEEHGDRLPTSATCMN 3042
             ++ + + L+FVTG  R PL GF  L       KFCI++ G          LP S TC N
Sbjct: 835  DNEVRMRLLQFVTGTCRLPLGGFAELMGSNGPQKFCIEKVG------KDTWLPRSHTCFN 888

Query: 3043 LLKLPPYRTKEQLQTKLLYAINSEAGF 3123
             L LPPY++ EQL+ KLL+AI    GF
Sbjct: 889  RLDLPPYKSYEQLKEKLLFAIEETEGF 915

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>Q9H0M0:WWP1_HUMAN NEDD4-like E3 ubiquitin-protein ligase WWP1 - Homo sapiens (Human)|
          Length = 922

 Score =  185 bits (470), Expect = 1e-45
 Identities = 117/387 (30%), Positives = 200/387 (51%), Gaps = 7/387 (1%)
 Frame = +1

Query: 1984 FTSQLANSKQSTASHSALTRHRFKIRRSRLLEDAFDQLSLLSEEDLKGPIRVSFVNEHGV 2163
            F  +LA+ +    S++  +  +  + R  L ED+F Q+  L   DL+  + V F  E G 
Sbjct: 547  FRWKLAHFRYLCQSNALPSHVKINVSRQTLFEDSFQQIMALKPYDLRRRLYVIFRGEEG- 605

Query: 2164 EEAGIDGGGIFKDFMENITRAAFDVQYGLFKETV--DHVLYPNPGSGLVHEQHLQYFHFL 2337
                +D GG+ +++   ++    +  Y LF+     ++ L  NP S  ++  HL YF F+
Sbjct: 606  ----LDYGGLAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPAS-TINPDHLSYFCFI 660

Query: 2338 GSLLGKAMYEGILVDLPFATFFLSKLKEKSNFLNDLPSLDPELYRHLLFLKHYKGDVSDL 2517
            G  +  A++ G  +D  F+  F  ++  K   + DL S+D E Y  L++++    +   L
Sbjct: 661  GRFIAMALFHGKFIDTGFSLPFYKRMLSKKLTIKDLESIDTEFYNSLIWIRDNNIEECGL 720

Query: 2518 ELYFVIVNNEYGEQAEEELLPGGREMRVTNQNVITFIHLVANHRLNYQIRGQGRHFLRGF 2697
            E+YF +     G+    +L  GG  + VT +N   +I L+   R +  ++ Q + FL GF
Sbjct: 721  EMYFSVDMEILGKVTSHDLKLGGSNILVTEENKDEYIGLMTEWRFSRGVQEQTKAFLDGF 780

Query: 2698 QKLIPKEWIDMFNEHEIQLLISGSLESLDIDDLRLNTNYSGGYHPDHEIIDMLWEVLKSF 2877
             +++P +W+  F+E E+++++ G ++ +D+ D + NT Y   Y  + + I   W+ +K  
Sbjct: 781  NEVVPLQWLQYFDEKELEVMLCG-MQEVDLADWQRNTVYR-HYTRNSKQIIWFWQFVKET 838

Query: 2878 SSDNQKKFLKFVTGCSRGPLLGFEYL-----DPKFCIQRAGVPGLEEHGDRLPTSATCMN 3042
             ++ + + L+FVTG  R PL GF  L       KFCI++ G          LP S TC N
Sbjct: 839  DNEVRMRLLQFVTGTCRLPLGGFAELMGSNGPQKFCIEKVG------KDTWLPRSHTCFN 892

Query: 3043 LLKLPPYRTKEQLQTKLLYAINSEAGF 3123
             L LPPY++ EQL+ KLL+AI    GF
Sbjct: 893  RLDLPPYKSYEQLKEKLLFAIEETEGF 919

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>Q9Y0H4:SUDX_DROME E3 ubiquitin-protein ligase suppressor of deltex - Drosophila|
            melanogaster (Fruit fly)
          Length = 949

 Score =  183 bits (465), Expect = 4e-45
 Identities = 114/373 (30%), Positives = 193/373 (51%), Gaps = 8/373 (2%)
 Frame = +1

Query: 2029 SALTRH-RFKIRRSRLLEDAFDQLSLLSEEDLKGPIRVSFVNEHGVEEAGIDGGGIFKDF 2205
            +AL  H +  + R  L ED++ Q+  L   +L+  + + F  E G     +D GG+ +++
Sbjct: 588  NALPSHIKITVTRQTLFEDSYHQIMRLPAYELRRRLYIIFRGEEG-----LDYGGVSREW 642

Query: 2206 MENITRAAFDVQYGLFK--ETVDHVLYPNPGSGLVHEQHLQYFHFLGSLLGKAMYEGILV 2379
               ++    +  Y LF+     ++ L  NP S  V+  HLQYF F+G  +  A+Y G  +
Sbjct: 643  FFLLSHEVLNPMYCLFEYANKNNYSLQINPAS-YVNPDHLQYFKFIGRFIAMALYHGRFI 701

Query: 2380 DLPFATFFLSKLKEKSNFLNDLPSLDPELYRHLLFLKHYKGDVSDLELYFVIVNNEYGEQ 2559
               F   F  ++  K   + D+ ++DPE Y  L+++K    D   LEL+F +     G+ 
Sbjct: 702  YSGFTMPFYKRMLNKKLTIKDIETIDPEFYNSLIWVKDNNIDECGLELWFSVDFEVLGQI 761

Query: 2560 AEEELLPGGREMRVTNQNVITFIHLVANHRLNYQIRGQGRHFLRGFQKLIPKEWIDMFNE 2739
               EL   G + RVT +N   +I L+   R+   I  Q + FL GF +++P EW+  F+E
Sbjct: 762  IHHELKENGEKERVTEENKEEYITLMTEWRMTRGIEQQTKTFLEGFNEVVPLEWLKYFDE 821

Query: 2740 HEIQLLISGSLESLDIDDLRLNTNYSGGYHPDHEIIDMLWEVLKSFSSDNQKKFLKFVTG 2919
             E++L++ G ++ +D++D + NT Y   Y+ + + +   W+ ++   ++ + + L+FVTG
Sbjct: 822  RELELILCG-MQDVDVEDWQRNTIYR-HYNRNSKQVVWFWQFVRETDNEKRARLLQFVTG 879

Query: 2920 CSRGPLLGFEYL-----DPKFCIQRAGVPGLEEHGDRLPTSATCMNLLKLPPYRTKEQLQ 3084
              R P+ GF  L       +FCI++ G          LP S TC N L LPPY++ +QL 
Sbjct: 880  TCRVPVGGFAELMGSNGPQRFCIEKVG------KETWLPRSHTCFNRLDLPPYKSYDQLV 933

Query: 3085 TKLLYAINSEAGF 3123
             KL +AI    GF
Sbjct: 934  EKLTFAIEETEGF 946

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>Q6I6G8:HECW2_MOUSE E3 ubiquitin-protein ligase HECW2 - Mus musculus (Mouse)|
          Length = 1578

 Score =  182 bits (463), Expect = 6e-45
 Identities = 121/367 (32%), Positives = 193/367 (52%), Gaps = 9/367 (2%)
 Frame = +1

Query: 2056 IRRSRLLEDAFDQLSLLSEEDL-KGPIRVSFVNEHGVEEAGIDGGGIFKDFMENITRAAF 2232
            IRR  LLEDAF+Q+   S +DL +  + V+FV E G     +D  G  ++F   ++R  F
Sbjct: 1226 IRRDHLLEDAFNQIMGYSRKDLQRNKLYVTFVGEEG-----LDYSGPSREFFFLVSRELF 1280

Query: 2233 DVQYGLFKETVD--HVLYPNPGSGLVHEQHLQYFHFLGSLLGKAMYEGILVDLPFATFFL 2406
            +  YGLF+ + +  + +  +P S  V   H ++F F G +LG A+    L+D  F   F 
Sbjct: 1281 NPYYGLFEYSANDTYTVQISPMSAFVDNHH-EWFRFSGRILGLALIHQYLLDAFFTRPFY 1339

Query: 2407 SKLKEKSNFLNDLPSLDPELYRHLLFLKHYKGDVSD-LELYFVIVNNEYGEQAEEELLPG 2583
              L      L+DL  LD E ++ L ++K    D+ D L+L F +    +G+  E EL PG
Sbjct: 1340 KALLRILCDLSDLEYLDEEFHQSLQWMKD--NDIHDILDLTFTVNEEVFGQITERELKPG 1397

Query: 2584 GREMRVTNQNVITFIHLVANHRLNYQIRGQGRHFLRGFQKLIPKEWIDMFNEHEIQLLIS 2763
            G  + VT +N   +I  +   R+   +  Q    +RGF +++    + +F+  E++L+I+
Sbjct: 1398 GANIPVTEKNKKEYIERMVKWRIERGVVQQTESLVRGFYEVVDARLVSVFDARELELVIA 1457

Query: 2764 GSLESLDIDDLRLNTNYSGGYHPDHEIIDMLWEVLKSFSSDNQKKFLKFVTGCSRGPLLG 2943
            G+ E +D++D R NT Y GGYH +H +I   W  ++ F+++ + + L+FVTG S  P  G
Sbjct: 1458 GTAE-IDLNDWRNNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLRLLQFVTGTSSIPYEG 1516

Query: 2944 FEYL-----DPKFCIQRAGVPGLEEHGDRLPTSATCMNLLKLPPYRTKEQLQTKLLYAIN 3108
            F  L       +FC+++ G          LP + TC N L LPPY +   L  KLL A+ 
Sbjct: 1517 FASLRGSNGPRRFCVEKWG------KITALPRAHTCFNRLDLPPYPSFSMLYEKLLTAVE 1570

Query: 3109 SEAGFDL 3129
              + F L
Sbjct: 1571 ETSTFGL 1577

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>Q9P2P5:HECW2_HUMAN E3 ubiquitin-protein ligase HECW2 - Homo sapiens (Human)|
          Length = 1572

 Score =  182 bits (462), Expect = 8e-45
 Identities = 121/367 (32%), Positives = 192/367 (52%), Gaps = 9/367 (2%)
 Frame = +1

Query: 2056 IRRSRLLEDAFDQLSLLSEEDL-KGPIRVSFVNEHGVEEAGIDGGGIFKDFMENITRAAF 2232
            IRR  LLEDAF+Q+   S +DL +  + V+FV E G     +D  G  ++F   ++R  F
Sbjct: 1220 IRRDHLLEDAFNQIMGYSRKDLQRNKLYVTFVGEEG-----LDYSGPSREFFFLVSRELF 1274

Query: 2233 DVQYGLFKETVD--HVLYPNPGSGLVHEQHLQYFHFLGSLLGKAMYEGILVDLPFATFFL 2406
            +  YGLF+ + +  + +  +P S  V   H ++F F G +LG A+    L+D  F   F 
Sbjct: 1275 NPYYGLFEYSANDTYTVQISPMSAFVDNHH-EWFRFSGRILGLALIHQYLLDAFFTRPFY 1333

Query: 2407 SKLKEKSNFLNDLPSLDPELYRHLLFLKHYKGDVSD-LELYFVIVNNEYGEQAEEELLPG 2583
              L      L+DL  LD E ++ L ++K    D+ D L+L F +    +G+  E EL PG
Sbjct: 1334 KALLRILCDLSDLEYLDEEFHQSLQWMKD--NDIHDILDLTFTVNEEVFGQITERELKPG 1391

Query: 2584 GREMRVTNQNVITFIHLVANHRLNYQIRGQGRHFLRGFQKLIPKEWIDMFNEHEIQLLIS 2763
            G  + VT +N   +I  +   R+   +  Q    +RGF +++    + +F+  E++L+I+
Sbjct: 1392 GANIPVTEKNKKEYIERMVKWRIERGVVQQTESLVRGFYEVVDARLVSVFDARELELVIA 1451

Query: 2764 GSLESLDIDDLRLNTNYSGGYHPDHEIIDMLWEVLKSFSSDNQKKFLKFVTGCSRGPLLG 2943
            G+ E +D+ D R NT Y GGYH +H +I   W  ++ F+++ + + L+FVTG S  P  G
Sbjct: 1452 GTAE-IDLSDWRNNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLRLLQFVTGTSSIPYEG 1510

Query: 2944 FEYL-----DPKFCIQRAGVPGLEEHGDRLPTSATCMNLLKLPPYRTKEQLQTKLLYAIN 3108
            F  L       +FC+++ G          LP + TC N L LPPY +   L  KLL A+ 
Sbjct: 1511 FASLRGSNGPRRFCVEKWG------KITALPRAHTCFNRLDLPPYPSFSMLYEKLLTAVE 1564

Query: 3109 SEAGFDL 3129
              + F L
Sbjct: 1565 ETSTFGL 1571

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>Q3U0D9:HACE1_MOUSE E3 ubiquitin-protein ligase HACE1 - Mus musculus (Mouse)|
          Length = 909

 Score =  181 bits (458), Expect = 2e-44
 Identities = 115/366 (31%), Positives = 185/366 (50%), Gaps = 2/366 (0%)
 Frame = +1

Query: 2056 IRRSRLLEDAFDQLSLLSEEDLKGPIRVSFVNEHGVEEAGIDGGGIFKDFMENITRAAFD 2235
            + R  +   + + +S  +   LK  I V F  E G+      G G+ +++ + ++    +
Sbjct: 557  VHRDSIFRSSCEIVSKANCAKLKQGIAVRFHGEEGM------GQGVVREWFDILSNEIVN 610

Query: 2236 VQYGLFKETVDHVLYPNPGSGLVHEQHLQYFHFLGSLLGKAMYEGILVDLPFATFFLSKL 2415
              Y LF ++ D   +    +  V+  HL YF F G +LG A+    LV++ F   F   +
Sbjct: 611  PDYALFTQSADGTTFQPNSNSYVNPDHLNYFRFAGQILGLALNHRQLVNIYFTRSFYKHI 670

Query: 2416 KEKSNFLNDLPSLDPELYRHLLFLKHYKGDVSDL--ELYFVIVNNEYGEQAEEELLPGGR 2589
                    D+ S+DPE  ++L ++     D+SDL  EL F +  + +G   E  L PGG 
Sbjct: 671  LGIPVNYQDVASIDPEYAKNLQWI--LDNDISDLGLELTFSVETDVFGAMEEVPLKPGGG 728

Query: 2590 EMRVTNQNVITFIHLVANHRLNYQIRGQGRHFLRGFQKLIPKEWIDMFNEHEIQLLISGS 2769
             + VT  N   ++ LV   R+   I+ Q   FL+GF   IP   I +F+E+E++LL+SG 
Sbjct: 729  SILVTQNNKAEYVQLVTELRMTRAIQPQINAFLQGFHMFIPPSLIQLFDEYELELLLSGM 788

Query: 2770 LESLDIDDLRLNTNYSGGYHPDHEIIDMLWEVLKSFSSDNQKKFLKFVTGCSRGPLLGFE 2949
             E +D++D   NT Y+ GY  +  +I   WEV++  + + +   L+FVTG SR P  GF 
Sbjct: 789  PE-IDVNDWIKNTEYTSGYEREDPVIQWFWEVVEDITQEERVLLLQFVTGSSRVPHGGFA 847

Query: 2950 YLDPKFCIQRAGVPGLEEHGDRLPTSATCMNLLKLPPYRTKEQLQTKLLYAINSEAGFDL 3129
             +     +Q   +  +    + LPTS+TC+N+LKLP Y +KE L+ +LL A         
Sbjct: 848  NIMGGSGLQNFTIAAVPYTPNLLPTSSTCINMLKLPEYPSKEILKDRLLVA--------- 898

Query: 3130 S*LHCG 3147
              LHCG
Sbjct: 899  --LHCG 902

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>Q8IYU2:HACE1_HUMAN E3 ubiquitin-protein ligase HACE1 - Homo sapiens (Human)|
          Length = 909

 Score =  181 bits (458), Expect = 2e-44
 Identities = 115/366 (31%), Positives = 184/366 (50%), Gaps = 2/366 (0%)
 Frame = +1

Query: 2056 IRRSRLLEDAFDQLSLLSEEDLKGPIRVSFVNEHGVEEAGIDGGGIFKDFMENITRAAFD 2235
            + R  +   + + +S  +   LK  I V F  E G+      G G+ +++ + ++    +
Sbjct: 557  VHRDSIFRSSCEVVSKANCAKLKQGIAVRFHGEEGM------GQGVVREWFDILSNEIVN 610

Query: 2236 VQYGLFKETVDHVLYPNPGSGLVHEQHLQYFHFLGSLLGKAMYEGILVDLPFATFFLSKL 2415
              Y LF ++ D   +    +  V+  HL YF F G +LG A+    LV++ F   F   +
Sbjct: 611  PDYALFTQSADGTTFQPNSNSYVNPDHLNYFRFAGQILGLALNHRQLVNIYFTRSFYKHI 670

Query: 2416 KEKSNFLNDLPSLDPELYRHLLFLKHYKGDVSDL--ELYFVIVNNEYGEQAEEELLPGGR 2589
                    D+ S+DPE  ++L ++     D+SDL  EL F +  + +G   E  L PGG 
Sbjct: 671  LGIPVNYQDVASIDPEYAKNLQWI--LDNDISDLGLELTFSVETDVFGAMEEVPLKPGGG 728

Query: 2590 EMRVTNQNVITFIHLVANHRLNYQIRGQGRHFLRGFQKLIPKEWIDMFNEHEIQLLISGS 2769
             + VT  N   ++ LV   R+   I+ Q   FL+GF   IP   I +F+E+E++LL+SG 
Sbjct: 729  SILVTQNNKAEYVQLVTELRMTRAIQPQINAFLQGFHMFIPPSLIQLFDEYELELLLSGM 788

Query: 2770 LESLDIDDLRLNTNYSGGYHPDHEIIDMLWEVLKSFSSDNQKKFLKFVTGCSRGPLLGFE 2949
             E +D+ D   NT Y+ GY  +  +I   WEV++  + + +   L+FVTG SR P  GF 
Sbjct: 789  PE-IDVSDWIKNTEYTSGYEREDPVIQWFWEVVEDITQEERVLLLQFVTGSSRVPHGGFA 847

Query: 2950 YLDPKFCIQRAGVPGLEEHGDRLPTSATCMNLLKLPPYRTKEQLQTKLLYAINSEAGFDL 3129
             +     +Q   +  +    + LPTS+TC+N+LKLP Y +KE L+ +LL A         
Sbjct: 848  NIMGGSGLQNFTIAAVPYTPNLLPTSSTCINMLKLPEYPSKEILKDRLLVA--------- 898

Query: 3130 S*LHCG 3147
              LHCG
Sbjct: 899  --LHCG 902

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>Q05086:UBE3A_HUMAN Ubiquitin-protein ligase E3A - Homo sapiens (Human)|
          Length = 875

 Score =  177 bits (449), Expect = 3e-43
 Identities = 124/368 (33%), Positives = 190/368 (51%), Gaps = 7/368 (1%)
 Frame = +1

Query: 2047 RFKIRRSRLLEDAFDQLSLLSEE---DLKGPIRVSFVNEHGVEEAGIDGGGIFKDFMENI 2217
            R K+RR  +++DA  +L +++ E   DLK  + V F  E GV+E     GG+ K+F + +
Sbjct: 524  RLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDE-----GGVSKEFFQLV 578

Query: 2218 TRAAFDVQYGLFK-ETVDHVLYPNPGSGLVHEQHLQYFHFLGSLLGKAMYEGILVDLPFA 2394
                F+   G+F  +    + + NP S     Q    F  +G +LG A+Y   ++D+ F 
Sbjct: 579  VEEIFNPDIGMFTYDESTKLFWFNPSSFETEGQ----FTLIGIVLGLAIYNNCILDVHFP 634

Query: 2395 TFFLSKLKEKSNFLNDLPSLDPELYRHLLFLKHYKGDVSD-LELYFVIVNNE-YGEQAEE 2568
                 KL  K     DL    P LY+ L  L  Y+G+V D + + F I   + +G     
Sbjct: 635  MVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMY 694

Query: 2569 ELLPGGREMRVTNQNVITFIHLVANHRLNYQIRGQGRHFLRGFQKLIPKEWID-MFNEHE 2745
            +L   G ++ +TN+N   F++L +++ LN  +  Q + F RGF  +  +  +  +F   E
Sbjct: 695  DLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEE 754

Query: 2746 IQLLISGSLESLDIDDLRLNTNYSGGYHPDHEIIDMLWEVLKSFSSDNQKKFLKFVTGCS 2925
            I+LLI GS  +LD   L   T Y GGY  D  +I   WE++ SF+ + ++ FL+F TG  
Sbjct: 755  IELLICGS-RNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTD 813

Query: 2926 RGPLLGFEYLDPKFCIQRAGVPGLEEHGDRLPTSATCMNLLKLPPYRTKEQLQTKLLYAI 3105
            R P+ G   L  K  I + G P  E    RLPTS TC N+L LP Y +KE+L+ +LL AI
Sbjct: 814  RAPVGGLGKL--KMIIAKNG-PDTE----RLPTSHTCFNVLLLPEYSSKEKLKERLLKAI 866

Query: 3106 NSEAGFDL 3129
                GF +
Sbjct: 867  TYAKGFGM 874

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>P39940:RSP5_YEAST E3 ubiquitin-protein ligase RSP5 - Saccharomyces cerevisiae (Baker's|
            yeast)
          Length = 809

 Score =  177 bits (448), Expect = 4e-43
 Identities = 109/364 (29%), Positives = 191/364 (52%), Gaps = 7/364 (1%)
 Frame = +1

Query: 2053 KIRRSRLLEDAFDQLSLLSEEDLKGPIRVSFVNEHGVEEAGIDGGGIFKDFMENITRAAF 2232
            K+RR  + EDA+ ++   + EDLK  + + F  E G     +D GG+ ++F   ++   F
Sbjct: 458  KVRRKNIFEDAYQEIMRQTPEDLKKRLMIKFDGEEG-----LDYGGVSREFFFLLSHEMF 512

Query: 2233 DVQYGLFKETV--DHVLYPNPGSGLVHEQHLQYFHFLGSLLGKAMYEGILVDLPFATFFL 2406
            +  Y LF+ +   ++ +  NP SG ++ +HL YF F+G ++G  ++    +D  F     
Sbjct: 513  NPFYCLFEYSAYDNYTIQINPNSG-INPEHLNYFKFIGRVVGLGVFHRRFLDAFFVGALY 571

Query: 2407 SKLKEKSNFLNDLPSLDPELYRHLLFLKHYKGDVSDLELYFVIVNNEYGEQAEEELLPGG 2586
              +  K   L D+  +D E+Y  L ++     D   L+L F   +  +GE    +L P G
Sbjct: 572  KMMLRKKVVLQDMEGVDAEVYNSLNWMLENSID-GVLDLTFSADDERFGEVVTVDLKPDG 630

Query: 2587 REMRVTNQNVITFIHLVANHRLNYQIRGQGRHFLRGFQKLIPKEWIDMFNEHEIQLLISG 2766
            R + VT+ N   ++ L    R+  +++ Q + F+ GF +LIP++ + +F+E E++LLI G
Sbjct: 631  RNIEVTDGNKKEYVELYTQWRIVDRVQEQFKAFMDGFNELIPEDLVTVFDERELELLIGG 690

Query: 2767 SLESLDIDDLRLNTNYSGGYHPDHEIIDMLWEVLKSFSSDNQKKFLKFVTGCSRGPLLGF 2946
              E +DI+D + +T+Y  GY    E+I   W+ +  + ++ + + L+F TG SR P+ GF
Sbjct: 691  IAE-IDIEDWKKHTDYR-GYQESDEVIQWFWKCVSEWDNEQRARLLQFTTGTSRIPVNGF 748

Query: 2947 EYLD-----PKFCIQRAGVPGLEEHGDRLPTSATCMNLLKLPPYRTKEQLQTKLLYAINS 3111
            + L       +F I++AG         +LP S TC N + LP Y   + ++ KL  A+  
Sbjct: 749  KDLQGSDGPRRFTIEKAG------EVQQLPKSHTCFNRVDLPQYVDYDSMKQKLTLAVEE 802

Query: 3112 EAGF 3123
              GF
Sbjct: 803  TIGF 806

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>Q76N89:HECW1_HUMAN E3 ubiquitin-protein ligase HECW1 - Homo sapiens (Human)|
          Length = 1606

 Score =  176 bits (447), Expect = 5e-43
 Identities = 118/367 (32%), Positives = 192/367 (52%), Gaps = 9/367 (2%)
 Frame = +1

Query: 2056 IRRSRLLEDAFDQLSLLSEEDL-KGPIRVSFVNEHGVEEAGIDGGGIFKDFMENITRAAF 2232
            IRR  LLE  F+Q+   S ++L +  + V+FV E G     +D  G  ++F   +++  F
Sbjct: 1254 IRRDHLLEGTFNQVMAYSRKELQRNKLYVTFVGEEG-----LDYSGPSREFFFLLSQELF 1308

Query: 2233 DVQYGLFKETVD--HVLYPNPGSGLVHEQHLQYFHFLGSLLGKAMYEGILVDLPFATFFL 2406
            +  YGLF+ + +  + +  +P S  V E HL++F F G +LG A+    L+D  F   F 
Sbjct: 1309 NPYYGLFEYSANDTYTVQISPMSAFV-ENHLEWFRFSGRILGLALIHQYLLDAFFTRPFY 1367

Query: 2407 SKLKEKSNFLNDLPSLDPELYRHLLFLKHYKGDVSD-LELYFVIVNNEYGEQAEEELLPG 2583
              L      L+DL  LD E ++ L ++K    +++D L+L F +    +G+  E EL  G
Sbjct: 1368 KALLRLPCDLSDLEYLDEEFHQSLQWMKD--NNITDILDLTFTVNEEVFGQVTERELKSG 1425

Query: 2584 GREMRVTNQNVITFIHLVANHRLNYQIRGQGRHFLRGFQKLIPKEWIDMFNEHEIQLLIS 2763
            G   +VT +N   +I  +   R+   +  Q    +RGF +++    + +F+  E++L+I+
Sbjct: 1426 GANTQVTEKNKKEYIERMVKWRVERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIA 1485

Query: 2764 GSLESLDIDDLRLNTNYSGGYHPDHEIIDMLWEVLKSFSSDNQKKFLKFVTGCSRGPLLG 2943
            G+ E +D++D R NT Y GGYH  H +I   W  ++ F+++ + + L+FVTG S  P  G
Sbjct: 1486 GTAE-IDLNDWRNNTEYRGGYHDGHLVIRWFWAAVERFNNEQRLRLLQFVTGTSSVPYEG 1544

Query: 2944 FEYLD-----PKFCIQRAGVPGLEEHGDRLPTSATCMNLLKLPPYRTKEQLQTKLLYAIN 3108
            F  L       +FCI++ G          LP + TC N L LPPY +   L  KLL A+ 
Sbjct: 1545 FAALRGSNGLRRFCIEKWG------KITSLPRAHTCFNRLDLPPYPSYSMLYEKLLTAVE 1598

Query: 3109 SEAGFDL 3129
              + F L
Sbjct: 1599 ETSTFGL 1605

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>Q8K4P8:HECW1_MOUSE E3 ubiquitin-protein ligase HECW1 - Mus musculus (Mouse)|
          Length = 1604

 Score =  175 bits (443), Expect = 1e-42
 Identities = 117/367 (31%), Positives = 193/367 (52%), Gaps = 9/367 (2%)
 Frame = +1

Query: 2056 IRRSRLLEDAFDQLSLLSEEDL-KGPIRVSFVNEHGVEEAGIDGGGIFKDFMENITRAAF 2232
            IRR  LLE  F+Q+   S ++L +  + ++FV E G     +D  G  ++F   +++  F
Sbjct: 1252 IRRDHLLEGTFNQVMAYSRKELQRNKLYITFVGEEG-----LDYSGPSREFFFLLSQELF 1306

Query: 2233 DVQYGLFKETVD--HVLYPNPGSGLVHEQHLQYFHFLGSLLGKAMYEGILVDLPFATFFL 2406
            +  YGLF+ + +  + +  +P S  V E +L++F F G +LG A+    L+D  F   F 
Sbjct: 1307 NPYYGLFEYSANDTYTVQISPMSAFV-ENYLEWFRFSGRILGLALIHQYLLDAFFTRPFY 1365

Query: 2407 SKLKEKSNFLNDLPSLDPELYRHLLFLKHYKGDVSD-LELYFVIVNNEYGEQAEEELLPG 2583
              L +    L+DL  LD E ++ L ++K    +++D L+L F +    +G+  E EL  G
Sbjct: 1366 KGLLKLPCDLSDLEYLDEEFHQSLQWMKD--NNITDILDLTFTVNEEVFGQVTERELKSG 1423

Query: 2584 GREMRVTNQNVITFIHLVANHRLNYQIRGQGRHFLRGFQKLIPKEWIDMFNEHEIQLLIS 2763
            G   +VT +N   +I  +   R+   +  Q    LRGF +++    + +F+  E++L+I+
Sbjct: 1424 GANTQVTEKNKKEYIERMVKWRVERGVVQQTEALLRGFYEVVDSRLVSVFDARELELVIA 1483

Query: 2764 GSLESLDIDDLRLNTNYSGGYHPDHEIIDMLWEVLKSFSSDNQKKFLKFVTGCSRGPLLG 2943
            G+ E +D++D R NT Y GGYH  H +I   W  ++ F+++ + + L+FVTG S  P  G
Sbjct: 1484 GTAE-IDLNDWRNNTEYRGGYHDGHLVIRWFWAAVERFNNEQRLRLLQFVTGTSSVPYEG 1542

Query: 2944 FEYLD-----PKFCIQRAGVPGLEEHGDRLPTSATCMNLLKLPPYRTKEQLQTKLLYAIN 3108
            F  L       +FCI++ G          LP + TC N L LPPY +   L  KLL A+ 
Sbjct: 1543 FAALRGSNGLRRFCIEKWG------KITSLPRAHTCFNRLDLPPYPSYSMLYEKLLTAVE 1596

Query: 3109 SEAGFDL 3129
              + F L
Sbjct: 1597 ETSTFGL 1603

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>Q5GLZ8:HERC4_HUMAN Probable E3 ubiquitin-protein ligase HERC4 - Homo sapiens (Human)|
          Length = 1057

 Score =  169 bits (427), Expect = 1e-40
 Identities = 121/362 (33%), Positives = 175/362 (48%), Gaps = 4/362 (1%)
 Frame = +1

Query: 2056 IRRSRLLEDAFDQLSLLSEEDLKGPIRVSFVNEHGVEEAGIDGGGIFKDFMENITRAAFD 2235
            +RR  ++ DA + L      D K P++V FV E  V     D GG+ K+F   I R   D
Sbjct: 713  VRRENIVGDAMEVLRKTKNIDYKKPLKVIFVGEDAV-----DAGGVRKEFFLLIMRELLD 767

Query: 2236 VQYGLFKETVDHVLYPNPGSGLVHEQHLQYFHFLGSLLGKAMYEGILVDLPFATFFLSKL 2415
             +YG+F+   D  L           +    FH +G + G A+Y   +VDL F      KL
Sbjct: 768  PKYGMFRYYEDSRLIWFSDKTF---EDSDLFHLIGVICGLAIYNCTIVDLHFPLALYKKL 824

Query: 2416 KEKSNFLNDLPSLDPELYRHLLFLKHYKGDVSDLE----LYFVIVNNEYGEQAEEELLPG 2583
             +K   L+DL  L P++ R +  L  Y  D  D+E    L F I    +G    +EL+  
Sbjct: 825  LKKKPSLDDLKELMPDVGRSMQQLLDYPED--DIEETFCLNFTITVENFGATEVKELVLN 882

Query: 2584 GREMRVTNQNVITFIHLVANHRLNYQIRGQGRHFLRGFQKLIPKEWIDMFNEHEIQLLIS 2763
            G +  V  QN   F+    ++  N  +      F  GF K+   + + +F  +E+Q ++ 
Sbjct: 883  GADTAVNKQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVI 942

Query: 2764 GSLESLDIDDLRLNTNYSGGYHPDHEIIDMLWEVLKSFSSDNQKKFLKFVTGCSRGPLLG 2943
            G+  + D  +L  NT Y G Y  +H  I + WEV      + +K+FL F+TG  R P+LG
Sbjct: 943  GNT-NYDWKELEKNTEYKGEYWAEHPTIKIFWEVFHELPLEKKKQFLLFLTGSDRIPILG 1001

Query: 2944 FEYLDPKFCIQRAGVPGLEEHGDRLPTSATCMNLLKLPPYRTKEQLQTKLLYAINSEAGF 3123
             + L  K  IQ  G  G EE+   LP S TC NLL LP Y  KE L++KL+ AI+   GF
Sbjct: 1002 MKSL--KLVIQSTG--GGEEY---LPVSHTCFNLLDLPKYTEKETLRSKLIQAIDHNEGF 1054

Query: 3124 DL 3129
             L
Sbjct: 1055 SL 1056

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>O08759:UBE3A_MOUSE Ubiquitin-protein ligase E3A - Mus musculus (Mouse)|
          Length = 885

 Score =  166 bits (420), Expect = 6e-40
 Identities = 121/366 (33%), Positives = 184/366 (50%), Gaps = 7/366 (1%)
 Frame = +1

Query: 2053 KIRRSRLLEDAFDQLSLLSEE---DLKGPIRVSFVNEHGVEEAGIDGGGIFKDFMENITR 2223
            K+RR  +++DA  +L +++ E   DLK  + V F  E GV+E     GG+ K+F + +  
Sbjct: 537  KVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDE-----GGVSKEFFQLVVE 591

Query: 2224 AAFDVQYGLFK-ETVDHVLYPNPGSGLVHEQHLQYFHFLGSLLGKAMYEGILVDLPFATF 2400
              F+   G+F  +    + + NP S     Q    F  +G +LG A+Y   ++D+ F   
Sbjct: 592  EIFNPDIGMFTYDEATKLFWFNPSSFETEGQ----FTLIG-ILGLAIYNNCILDVHFPMV 646

Query: 2401 FLSKLKEKSNFLNDLPSLDPELYRHLLFLKHYKGDVSD-LELYFVIVNNE-YGEQAEEEL 2574
               KL  K     DL    P LY+ L  L  Y+G V D + + F I   + +G     +L
Sbjct: 647  VYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGSVEDDMMITFQISQTDLFGNPMMYDL 706

Query: 2575 LPGGREMRVTNQNVITFIHLVANHRLNYQIRGQGRHFLRGFQKLIPKEWID-MFNEHEIQ 2751
               G ++ +TN+N   F+   +++ LN  +  Q + F RGF  +  +  +  +F   EI+
Sbjct: 707  KENGDKIPITNENRKEFVISYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIE 766

Query: 2752 LLISGSLESLDIDDLRLNTNYSGGYHPDHEIIDMLWEVLKSFSSDNQKKFLKFVTGCSRG 2931
            LLI GS  +LD   L   T Y GGY  +  +I   WE++ SF+ + ++ FL F TG  R 
Sbjct: 767  LLICGS-RNLDFQALEETTEYDGGYTRESVVIREFWEIVHSFTDEQKRLFLLFTTGTDRA 825

Query: 2932 PLLGFEYLDPKFCIQRAGVPGLEEHGDRLPTSATCMNLLKLPPYRTKEQLQTKLLYAINS 3111
            P+ G   L  K  I + G P  E    RLPTS TC N+L LP Y +KE+L  +LL AI  
Sbjct: 826  PVGGLGKL--KMIIAKNG-PDTE----RLPTSHTCFNVLLLPEYSSKEKLNVRLLKAITY 878

Query: 3112 EAGFDL 3129
              GF +
Sbjct: 879  AKGFGM 884

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>Q6PAV2:HERC4_MOUSE Probable E3 ubiquitin-protein ligase HERC4 - Mus musculus (Mouse)|
          Length = 1057

 Score =  165 bits (418), Expect = 1e-39
 Identities = 120/362 (33%), Positives = 172/362 (47%), Gaps = 4/362 (1%)
 Frame = +1

Query: 2056 IRRSRLLEDAFDQLSLLSEEDLKGPIRVSFVNEHGVEEAGIDGGGIFKDFMENITRAAFD 2235
            +RR  ++ DA + L      D K P++V FV E  V     D GG+ K+F   I R   D
Sbjct: 713  VRRENIVGDAMEVLRKTKNIDYKKPLKVIFVGEDAV-----DAGGVRKEFFLLIMRELLD 767

Query: 2236 VQYGLFKETVDHVLYPNPGSGLVHEQHLQYFHFLGSLLGKAMYEGILVDLPFATFFLSKL 2415
             +YG+F+   D  L           +    FH +G + G A+Y   +VDL F      KL
Sbjct: 768  PKYGMFRYYEDSRLIWFSDKTF---EDSDLFHLIGVICGLAIYNFTIVDLHFPLALYKKL 824

Query: 2416 KEKSNFLNDLPSLDPELYRHLLFLKHYKGDVSDLE----LYFVIVNNEYGEQAEEELLPG 2583
             ++   L+DL  L P + R +  L  Y  D  D+E    L F I    +G    +EL+  
Sbjct: 825  LKRKPSLDDLKELMPAVGRSMQQLLDYPED--DIEETFCLNFTITVENFGATEVKELVLN 882

Query: 2584 GREMRVTNQNVITFIHLVANHRLNYQIRGQGRHFLRGFQKLIPKEWIDMFNEHEIQLLIS 2763
            G +  V  QN   F+    ++  N  +      F  GF K+   + + +F  +E+Q ++ 
Sbjct: 883  GADTAVNRQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVI 942

Query: 2764 GSLESLDIDDLRLNTNYSGGYHPDHEIIDMLWEVLKSFSSDNQKKFLKFVTGCSRGPLLG 2943
            G+  + D  +L  NT Y G Y  DH  I + WEV      + +K+FL F+TG  R P+LG
Sbjct: 943  GNT-NYDWKELEKNTEYKGEYWADHPTIKIFWEVFHELPLEKKKQFLLFLTGSDRIPILG 1001

Query: 2944 FEYLDPKFCIQRAGVPGLEEHGDRLPTSATCMNLLKLPPYRTKEQLQTKLLYAINSEAGF 3123
             + L  K  IQ  G  G E +   LP S TC NLL LP Y  KE L+ KL+ AI+   GF
Sbjct: 1002 MKSL--KLVIQSTG--GGESY---LPVSHTCFNLLDLPKYTEKETLRCKLIQAIDHNEGF 1054

Query: 3124 DL 3129
             L
Sbjct: 1055 SL 1056

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>Q5PQN1:HERC4_RAT Probable E3 ubiquitin-protein ligase HERC4 - Rattus norvegicus (Rat)|
          Length = 1057

 Score =  165 bits (417), Expect = 1e-39
 Identities = 119/362 (32%), Positives = 173/362 (47%), Gaps = 4/362 (1%)
 Frame = +1

Query: 2056 IRRSRLLEDAFDQLSLLSEEDLKGPIRVSFVNEHGVEEAGIDGGGIFKDFMENITRAAFD 2235
            +RR  ++ DA + L      D K P++V FV E  V     D GG+ K+F   I R   D
Sbjct: 713  VRRENIVGDAMEVLRKTKNIDYKKPLKVIFVGEDAV-----DAGGVRKEFFLLIMRELLD 767

Query: 2236 VQYGLFKETVDHVLYPNPGSGLVHEQHLQYFHFLGSLLGKAMYEGILVDLPFATFFLSKL 2415
             +YG+F+   D  L           +    FH +G + G A+Y   +VDL F      KL
Sbjct: 768  PKYGMFRYYEDSRLIWFSDKTF---EDSDLFHLIGVICGLAIYNFTIVDLHFPLALYKKL 824

Query: 2416 KEKSNFLNDLPSLDPELYRHLLFLKHYKGDVSDLE----LYFVIVNNEYGEQAEEELLPG 2583
             ++   L+DL  L P++ R +  L  Y  D  D+E    L F I    +G    +EL+  
Sbjct: 825  LKRKPSLDDLKELMPDVGRSMQQLLDYPED--DIEETFCLNFTITVENFGATEVKELVLN 882

Query: 2584 GREMRVTNQNVITFIHLVANHRLNYQIRGQGRHFLRGFQKLIPKEWIDMFNEHEIQLLIS 2763
            G +  V  QN   F+    ++  N  +      F  GF K+   + + +F  +E+Q ++ 
Sbjct: 883  GADTAVNKQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVI 942

Query: 2764 GSLESLDIDDLRLNTNYSGGYHPDHEIIDMLWEVLKSFSSDNQKKFLKFVTGCSRGPLLG 2943
            G+  + D  +L  NT Y G Y  +H  I + WEV      + +K+FL F+TG  R P+LG
Sbjct: 943  GNT-NYDWKELEKNTEYKGEYWAEHPTIKIFWEVFHELPLEKKKQFLLFLTGSDRIPILG 1001

Query: 2944 FEYLDPKFCIQRAGVPGLEEHGDRLPTSATCMNLLKLPPYRTKEQLQTKLLYAINSEAGF 3123
             + L  K  IQ  G  G E +   LP S TC NLL LP Y  KE L+ KL+ AI+   GF
Sbjct: 1002 MKSL--KLVIQSTG--GGESY---LPVSHTCFNLLDLPKYTEKETLRCKLIQAIDHNEGF 1054

Query: 3124 DL 3129
             L
Sbjct: 1055 SL 1056

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>Q15034:HERC3_HUMAN Probable E3 ubiquitin-protein ligase HERC3 - Homo sapiens (Human)|
          Length = 1050

 Score =  154 bits (389), Expect = 2e-36
 Identities = 111/363 (30%), Positives = 169/363 (46%), Gaps = 4/363 (1%)
 Frame = +1

Query: 2056 IRRSRLLEDAFDQLSLLSEEDLKGPIRVSFVNEHGVEEAGIDGGGIFKDFMENITRAAFD 2235
            +RR+ L+ DA  +LS+ S+ DLK P++V F  E  V     D GG+ K+F   + +   +
Sbjct: 706  VRRNNLVGDALRELSIHSDIDLKKPLKVIFDGEEAV-----DAGGVTKEFFLLLLKELLN 760

Query: 2236 VQYGLFKETVDHVLYPNPGSGLVHEQHLQYFHFLGSLLGKAMYEGILVDLPFATFFLSKL 2415
              YG+F    D  L     +  V      +FH +G   G A+Y   +VDL F      KL
Sbjct: 761  PIYGMFTYYQDSNLLWFSDTCFVEHN---WFHLIGITCGLAIYNSTVVDLHFPLALYKKL 817

Query: 2416 KEKSNFLNDLPSLDPELYRHLLFLKHYKGDVSDLE----LYFVIVNNEYGEQAEEELLPG 2583
                  L DL  L P   R L  L  Y G+  D+E    L F I    YG   +++L+PG
Sbjct: 818  LNVKPGLEDLKELSPTEGRSLQELLDYPGE--DVEETFCLNFTICRESYGVIEQKKLIPG 875

Query: 2584 GREMRVTNQNVITFIHLVANHRLNYQIRGQGRHFLRGFQKLIPKEWIDMFNEHEIQLLIS 2763
            G  + V   N   F+    N+     +      F  GF K+   + +++F   E++ ++ 
Sbjct: 876  GDNVTVCKDNRQEFVDAYVNYVFQISVHEWYTAFSSGFLKVCGGKVLELFQPSELRAMMV 935

Query: 2764 GSLESLDIDDLRLNTNYSGGYHPDHEIIDMLWEVLKSFSSDNQKKFLKFVTGCSRGPLLG 2943
            G+  + + ++L     Y G Y   H  + + WE    F  + +KKFL F+TG  R P+ G
Sbjct: 936  GN-SNYNWEELEETAIYKGDYSATHPTVKLFWETFHEFPLEKKKKFLLFLTGSDRIPIYG 994

Query: 2944 FEYLDPKFCIQRAGVPGLEEHGDRLPTSATCMNLLKLPPYRTKEQLQTKLLYAINSEAGF 3123
               L        +G    EE+   LP + TC NLL LP Y +KE L  +L  A+++  GF
Sbjct: 995  MASLQIVIQSTASG----EEY---LPVAHTCYNLLDLPKYSSKEILSARLTQALDNYEGF 1047

Query: 3124 DLS 3132
             L+
Sbjct: 1048 SLA 1050

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>Q757T0:HUL4_ASHGO Probable E3 ubiquitin-protein ligase HUL4 - Ashbya gossypii (Yeast)|
            (Eremothecium gossypii)
          Length = 839

 Score =  150 bits (379), Expect = 4e-35
 Identities = 118/422 (27%), Positives = 188/422 (44%), Gaps = 30/422 (7%)
 Frame = +1

Query: 1948 PFLAPFTIRVKIF---TSQLANSKQSTASHSALTRH-------RFKIRRSRLLEDAFDQL 2097
            PFL    +++ I    T +L       A   AL R        + ++RR  +  D+   +
Sbjct: 435  PFLFSLGMKISILEYETRRLMEYSAEQAFLKALDRKQVVDVYLKIRVRREFVTTDSLRSI 494

Query: 2098 SLLSEEDLKGPIRVSFVNEHGVEEAGIDGGGIFKDFMENITRAAFDVQYGLF-------- 2253
                ++DLK  +R+ FVNE      GID GG+ K++   +TR  F+   GLF        
Sbjct: 495  QN-QQKDLKKSLRIEFVNE-----PGIDAGGLRKEWFLLLTRDLFNPNNGLFVYVPESRL 548

Query: 2254 -----KETVDHVLYPNPGSGLVHEQHLQYFHFLGSLLGKAMYEGILVDLPFATFFLSKLK 2418
                  E+++H L    GS        + ++  G +LG A+Y   ++DL F   F  K+ 
Sbjct: 549  CWFSIMESIEHELLQGEGSSS------ELYYLFGVVLGLAIYNSTILDLKFPRAFYKKIC 602

Query: 2419 EKSNFLNDLPSLDPELYRHLLFLKHYKGDVSDLELYFVIVNNEYGEQAEE------ELLP 2580
             +   +ND   L PE   ++L +  Y G+  + +++ +     + ++ +E      +L P
Sbjct: 603  GEVLSVNDFLELYPETGTNMLKMLEYDGEDFE-DIFALTFETCFPDRFDESKIHYRQLCP 661

Query: 2581 GGREMRVTNQNVITFIHLVANHRLNYQIRGQGRHFLRGFQKLIPKEWIDMFNEHEIQLLI 2760
             G    VT +N   +  L  +  LN  I      F  GF  +I      +F   E++ L+
Sbjct: 662  DGSTQAVTRENKHEYFRLWMDFYLNRSIAPGFESFRNGFFHVIEGNSFRLFGSEELEQLV 721

Query: 2761 SGSLE-SLDIDDLRLNTNYSGGYHPDHEIIDMLWEVLKSFSSDNQKKFLKFVTGCSRGPL 2937
             GS E SLD+  LR  T Y GG+  +  ++   WE+L       Q+K L FVTG  R P 
Sbjct: 722  CGSNEQSLDVSMLRSVTRYQGGFDDNSPVVQWFWEILSEMEYPQQRKLLHFVTGSDRVPA 781

Query: 2938 LGFEYLDPKFCIQRAGVPGLEEHGDRLPTSATCMNLLKLPPYRTKEQLQTKLLYAINSEA 3117
             G   +  +    R+G        DRLP S TC N + L  Y+ KE L+ KL+ A+    
Sbjct: 782  TGVTTIPFRISRIRSG-------ADRLPLSHTCFNEICLHEYKDKETLRNKLIIALEESQ 834

Query: 3118 GF 3123
            G+
Sbjct: 835  GY 836

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>Q5RD78:HECD2_PONPY Probable E3 ubiquitin-protein ligase HECTD2 - Pongo pygmaeus|
            (Orangutan)
          Length = 776

 Score =  147 bits (372), Expect = 2e-34
 Identities = 116/374 (31%), Positives = 178/374 (47%), Gaps = 15/374 (4%)
 Frame = +1

Query: 2053 KIRRSRLLEDAFDQLSLLSEEDLKGPIRVSFVNEHGVEEAGIDGGGIFKDFMENITRAAF 2232
            K+RR+ L+ D+ D+L+     DLK  ++V+FV E     AG+D GG+ K++   + R  F
Sbjct: 420  KVRRTHLVSDSLDELTR-KRADLKKKLKVTFVGE-----AGLDMGGLTKEWFLLLIRQIF 473

Query: 2233 DVQYGLFKETVDHVLYPNPGSGLVHEQHLQYFHFLGSLLGKAMYEGILVDLPFATFFLSK 2412
               YG+F    D   + +  S    + + + F  +G L+G A+Y  I +D+ F      K
Sbjct: 474  HPDYGMFTYHKDS--HCHWFSSFKCDNYSE-FRLVGILMGLAVYNSITLDIRFPPCCYKK 530

Query: 2413 LKEK--------------SNFLNDLPSLDPELYRHLLFLKHYKGDVS-DLELYFVIVNNE 2547
            L                 S  ++DL  + PEL   L  L  ++G+V  D    F +   E
Sbjct: 531  LLSPPIIPSDQNIPVGICSVTVDDLCQIMPELAHGLSELLSHEGNVEEDFYSTFQVFQEE 590

Query: 2548 YGEQAEEELLPGGREMRVTNQNVITFIHLVANHRLNYQIRGQGRHFLRGFQKLIPKEWID 2727
            +G      L PGG ++ VTNQN   ++ L  +  LN  I  Q   F  GF  +     + 
Sbjct: 591  FGIIKSYNLKPGGDKISVTNQNRKEYVQLYTDFLLNKSIYKQFAAFYYGFHSVCASNALM 650

Query: 2728 MFNEHEIQLLISGSLESLDIDDLRLNTNYSGGYHPDHEIIDMLWEVLKSFSSDNQKKFLK 2907
            +    E+++L+ GS   LD+  L+ +T Y  GY      I   W+V+  F  D QKK L 
Sbjct: 651  LLRPEEVEILVCGS-PDLDMHALQRSTQYD-GYAKTDLTIKYFWDVVLGFPLDLQKKLLH 708

Query: 2908 FVTGCSRGPLLGFEYLDPKFCIQRAGVPGLEEHGDRLPTSATCMNLLKLPPYRTKEQLQT 3087
            F TG  R P+ G   L+ K       +   E   + LP + TC N L LPPY++K+ L+ 
Sbjct: 709  FTTGSDRVPVGGMADLNFK-------ISKNETSTNCLPVAHTCFNQLCLPPYKSKKDLKQ 761

Query: 3088 KLLYAINSEAGFDL 3129
            KL+  I++  GF L
Sbjct: 762  KLIIGISNSEGFGL 775

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>Q8CDU6:HECD2_MOUSE Probable E3 ubiquitin-protein ligase HECTD2 - Mus musculus (Mouse)|
          Length = 774

 Score =  147 bits (371), Expect = 3e-34
 Identities = 116/374 (31%), Positives = 179/374 (47%), Gaps = 15/374 (4%)
 Frame = +1

Query: 2053 KIRRSRLLEDAFDQLSLLSEEDLKGPIRVSFVNEHGVEEAGIDGGGIFKDFMENITRAAF 2232
            K+RR+ L+ D+ D+L+     DLK  ++V+FV E     AG+D GG+ K++   + R  F
Sbjct: 418  KVRRTHLVSDSLDELTR-KRADLKKKLKVTFVGE-----AGLDMGGLTKEWFLLLIRQIF 471

Query: 2233 DVQYGLFKETVDHVLYPNPGSGLVHEQHLQYFHFLGSLLGKAMYEGILVDLPFATFFLSK 2412
               YG+F    D   + +  S    + + + F  +G L+G A+Y  I +D+ F      K
Sbjct: 472  HPDYGMFTYHKDS--HCHWFSSFKCDNYSE-FRLVGILMGLAVYNSITLDIRFPPCCYKK 528

Query: 2413 LKEK--------------SNFLNDLPSLDPELYRHLLFLKHYKGDVS-DLELYFVIVNNE 2547
            L                 S  ++DL  + PEL   L  L  Y+G+V  D    F +   E
Sbjct: 529  LLSPPVVPSDQSTPVGICSVTIDDLCQVMPELAHGLKELLSYEGNVEEDFYSTFQVFQEE 588

Query: 2548 YGEQAEEELLPGGREMRVTNQNVITFIHLVANHRLNYQIRGQGRHFLRGFQKLIPKEWID 2727
            +G      L PGG ++ VTNQN   ++ L  +  LN  I  Q   F  GF  +     + 
Sbjct: 589  FGVIKSYNLKPGGDKIPVTNQNRREYVQLYTDFLLNKSIYKQFAAFYCGFHSVCASNALM 648

Query: 2728 MFNEHEIQLLISGSLESLDIDDLRLNTNYSGGYHPDHEIIDMLWEVLKSFSSDNQKKFLK 2907
            +    E+++L+ GS E LD+  L+ +T Y  GY      I   W+V+  F  + QKK L 
Sbjct: 649  LLRPEEVEILVCGSPE-LDMHALQRSTQYD-GYAKTDLTIRYFWDVVLGFPLELQKKLLH 706

Query: 2908 FVTGCSRGPLLGFEYLDPKFCIQRAGVPGLEEHGDRLPTSATCMNLLKLPPYRTKEQLQT 3087
            F TG  R P+ G   L+ K       +   E   + LP + TC N L LPPY++++ L+ 
Sbjct: 707  FTTGSDRVPVGGMADLNFK-------ISKNETSTNWLPVAHTCFNQLCLPPYKSRKDLKQ 759

Query: 3088 KLLYAINSEAGFDL 3129
            KL+  I++  GF L
Sbjct: 760  KLIIGISNSEGFGL 773

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>Q5U5R9:HECD2_HUMAN Probable E3 ubiquitin-protein ligase HECTD2 - Homo sapiens (Human)|
          Length = 776

 Score =  146 bits (369), Expect = 5e-34
 Identities = 115/374 (30%), Positives = 177/374 (47%), Gaps = 15/374 (4%)
 Frame = +1

Query: 2053 KIRRSRLLEDAFDQLSLLSEEDLKGPIRVSFVNEHGVEEAGIDGGGIFKDFMENITRAAF 2232
            K+RR+ L+ D+ D+L+     DLK  ++V+FV E     AG+D GG+ K++   + R  F
Sbjct: 420  KVRRTHLVSDSLDELTR-KRADLKKKLKVTFVGE-----AGLDMGGLTKEWFLLLIRQIF 473

Query: 2233 DVQYGLFKETVDHVLYPNPGSGLVHEQHLQYFHFLGSLLGKAMYEGILVDLPFATFFLSK 2412
               YG+F    D   + +  S    + + + F  +G L+G A+Y  I +D+ F      K
Sbjct: 474  HPDYGMFTYHKDS--HCHWFSSFKCDNYSE-FRLVGILMGLAVYNSITLDIRFPPCCYKK 530

Query: 2413 LKEKSNF--------------LNDLPSLDPELYRHLLFLKHYKGDVS-DLELYFVIVNNE 2547
            L                    ++DL  + PEL   L  L  ++G+V  D    F +   E
Sbjct: 531  LLSPPIIPSDQNIPVGICNVTVDDLCQIMPELAHGLSELLSHEGNVEEDFYSTFQVFQEE 590

Query: 2548 YGEQAEEELLPGGREMRVTNQNVITFIHLVANHRLNYQIRGQGRHFLRGFQKLIPKEWID 2727
            +G      L PGG ++ VTNQN   ++ L  +  LN  I  Q   F  GF  +     + 
Sbjct: 591  FGIIKSYNLKPGGDKISVTNQNRKEYVQLYTDFLLNKSIYKQFAAFYYGFHSVCASNALM 650

Query: 2728 MFNEHEIQLLISGSLESLDIDDLRLNTNYSGGYHPDHEIIDMLWEVLKSFSSDNQKKFLK 2907
            +    E+++L+ GS   LD+  L+ +T Y  GY      I   W+V+  F  D QKK L 
Sbjct: 651  LLRPEEVEILVCGS-PDLDMHALQRSTQYD-GYAKTDLTIKYFWDVVLGFPLDLQKKLLH 708

Query: 2908 FVTGCSRGPLLGFEYLDPKFCIQRAGVPGLEEHGDRLPTSATCMNLLKLPPYRTKEQLQT 3087
            F TG  R P+ G   L+ K       +   E   + LP + TC N L LPPY++K+ L+ 
Sbjct: 709  FTTGSDRVPVGGMADLNFK-------ISKNETSTNCLPVAHTCFNQLCLPPYKSKKDLKQ 761

Query: 3088 KLLYAINSEAGFDL 3129
            KL+  I++  GF L
Sbjct: 762  KLIIGISNSEGFGL 775

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>Q9UII4:HERC5_HUMAN Probable E3 ubiquitin-protein ligase HERC5 - Homo sapiens (Human)|
          Length = 1024

 Score =  145 bits (367), Expect = 9e-34
 Identities = 104/361 (28%), Positives = 167/361 (46%), Gaps = 5/361 (1%)
 Frame = +1

Query: 2056 IRRSRLLEDAFDQLSLLSEEDLKGPIRVSFVNEHGVEEAGIDGGGIFKDFMENITRAAFD 2235
            +RR+ L+ED  +QLS    EDL+  + VSF  E      G D GG+ K+F   +      
Sbjct: 685  VRRNHLIEDVLNQLSQFENEDLRKELWVSFSGE-----IGYDLGGVKKEFFYCLFAEMIQ 739

Query: 2236 VQYGLFKETVDHVLYPNPGSGLVHEQHLQY----FHFLGSLLGKAMYEGILVDLPFATFF 2403
             +YG+F       +YP   S +      ++    + F G L G +++   + +LPF    
Sbjct: 740  PEYGMF-------MYPEGASCMWFPVKPKFEKKRYFFFGVLCGLSLFNCNVANLPFPLAL 792

Query: 2404 LSKLKEKSNFLNDLPSLDPELYRHLLFLKHYKGDVSDLELYFVIVNNEYGEQAEEELLPG 2583
              KL ++   L DL  L P+L ++L  L   +GD  + E  F I  N + ++ +  L+P 
Sbjct: 793  FKKLLDQMPSLEDLKELSPDLGKNLQTLLDDEGD--NFEEVFYIHFNVHWDRNDTNLIPN 850

Query: 2584 GREMRVTNQNVITFIHLVANHRLNYQIRGQGRHFLRGFQKLIPKEWIDMFNEHEIQLLIS 2763
            G  + V   N   ++    N+  N  ++     F RGF K+  ++ I +F+  E++ +I 
Sbjct: 851  GSSITVNQTNKRDYVSKYINYIFNDSVKAVYEEFRRGFYKMCDEDIIKLFHPEELKDVIV 910

Query: 2764 GSLESLDIDDLRLNTNYSGGYHPDHEIIDMLWEVLKSFSSDNQKKFLKFVTGCSRGPLLG 2943
            G+ +  D      N  Y  GY+  H  I M W+     + + +KKFL F+TG  R  +  
Sbjct: 911  GNTD-YDWKTFEKNARYEPGYNSSHPTIVMFWKAFHKLTLEEKKKFLVFLTGTDRLQMKD 969

Query: 2944 FEYLDPKFCIQRAGVPGLEEHGDRLPTSA-TCMNLLKLPPYRTKEQLQTKLLYAINSEAG 3120
               +   FC         E   +R P  A TC ++L LP Y T E ++  L  AIN+  G
Sbjct: 970  LNNMKITFCCP-------ESWNERDPIRALTCFSVLFLPKYSTMETVEEALQEAINNNRG 1022

Query: 3121 F 3123
            F
Sbjct: 1023 F 1023

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>Q8CHG5:K0317_MOUSE Protein KIAA0317 - Mus musculus (Mouse)|
          Length = 823

 Score =  142 bits (358), Expect = 1e-32
 Identities = 111/375 (29%), Positives = 182/375 (48%), Gaps = 14/375 (3%)
 Frame = +1

Query: 2026 HSALTRHRFKIRRSRLLEDAFDQLSLLSEEDLKGPIRVSFVNEHGVEEAGIDGGGIFKDF 2205
            HS +T    K+ R  LLE +       S  D      V F +E       +D GG  +++
Sbjct: 459  HSKVT---LKVSRHALLESSLKATRNFSISDWSKNFEVVFQDEEA-----LDWGGPRREW 510

Query: 2206 MENITRAAFDVQYGLFKETVDH---VLYPNPGSGLVHEQHLQYFHFLGSLLGKAMYEGIL 2376
             E I +A FD    LF    D    +++PNP         L+ + F G L+GK +YE  L
Sbjct: 511  FELICKALFDTTSQLFARFTDSNQALVHPNPNRPA--HLRLKMYEFAGRLVGKCLYESSL 568

Query: 2377 -------VDLPFATFFLSKLKEKSNFLNDLPSLDPELYRH-LLFLKHYKGDVSDLELYFV 2532
                   V   F   FL+++           + DPE Y+  + F+ +   D+S++EL F 
Sbjct: 569  GGAYKQLVRARFTRSFLAQIIGLRMHYKYFETDDPEFYKSKVCFILN--NDMSEMELVFA 626

Query: 2533 IVNNEYGEQAEE--ELLPGGREMRVTNQNVITFIHLVANHRLNYQIRGQGRHFLRGFQKL 2706
                    Q ++  EL+ GG +  VTN N I +++L+A +RL  Q++ +  HFL+G  +L
Sbjct: 627  EEKYNKSGQLDKIVELMTGGAQTPVTNANKIFYLNLLAQYRLASQVKEEVEHFLKGLNEL 686

Query: 2707 IPKEWIDMFNEHEIQLLISGSLESLDIDDLRLNTNYSGG-YHPDHEIIDMLWEVLKSFSS 2883
            +P+  + +F+E+E++LL+ G+   +++ D + +    GG +H   +++   W V+ S + 
Sbjct: 687  VPENLLAIFDENELELLMCGT-GDINVSDFKAHAVVVGGSWHFREKVMRWFWAVVSSLTQ 745

Query: 2884 DNQKKFLKFVTGCSRGPLLGFEYLDPKFCIQRAGVPGLEEHGDRLPTSATCMNLLKLPPY 3063
            +   + L+F TG S+ P  GF  L P F I  A           LPT+ TC N L LP Y
Sbjct: 746  EELARLLQFTTGSSQLPPGGFAALCPSFQIIAAPT------HSTLPTAHTCFNQLCLPTY 799

Query: 3064 RTKEQLQTKLLYAIN 3108
             + E++   L  AI+
Sbjct: 800  DSYEEVHRMLQLAIS 814

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>O15033:K0317_HUMAN Protein KIAA0317 - Homo sapiens (Human)|
          Length = 823

 Score =  142 bits (357), Expect = 1e-32
 Identities = 111/375 (29%), Positives = 182/375 (48%), Gaps = 14/375 (3%)
 Frame = +1

Query: 2026 HSALTRHRFKIRRSRLLEDAFDQLSLLSEEDLKGPIRVSFVNEHGVEEAGIDGGGIFKDF 2205
            HS +T    K+ R  LLE +       S  D      V F +E       +D GG  +++
Sbjct: 459  HSKVT---LKVSRHALLESSLKATRNFSISDWSKNFEVVFQDEEA-----LDWGGPRREW 510

Query: 2206 MENITRAAFDVQYGLFKETVDH---VLYPNPGSGLVHEQHLQYFHFLGSLLGKAMYEGIL 2376
             E I +A FD    LF    D+   +++PNP         L+ + F G L+GK +YE  L
Sbjct: 511  FELICKALFDTTNQLFTRFSDNNQALVHPNPNRPA--HLRLKMYEFAGRLVGKCLYESSL 568

Query: 2377 -------VDLPFATFFLSKLKEKSNFLNDLPSLDPELYRH-LLFLKHYKGDVSDLELYFV 2532
                   V   F   FL+++           + DPE Y+  + F+ +   D+S++EL F 
Sbjct: 569  GGAYKQLVRARFTRSFLAQIIGLRMHYKYFETDDPEFYKSKVCFILN--NDMSEMELVFA 626

Query: 2533 IVNNEYGEQAEE--ELLPGGREMRVTNQNVITFIHLVANHRLNYQIRGQGRHFLRGFQKL 2706
                    Q ++  EL+ GG +  VTN N I +++L+A +RL  Q++ +  HFL+G  +L
Sbjct: 627  EEKYNKSGQLDKVVELMTGGAQTPVTNANKIFYLNLLAQYRLASQVKEEVEHFLKGLNEL 686

Query: 2707 IPKEWIDMFNEHEIQLLISGSLESLDIDDLRLNTNYSGG-YHPDHEIIDMLWEVLKSFSS 2883
            +P+  + +F+E+E++LL+ G+   + + D + +    GG +H   +++   W V+ S + 
Sbjct: 687  VPENLLAIFDENELELLMCGT-GDISVSDFKAHAVVVGGSWHFREKVMRWFWTVVSSLTQ 745

Query: 2884 DNQKKFLKFVTGCSRGPLLGFEYLDPKFCIQRAGVPGLEEHGDRLPTSATCMNLLKLPPY 3063
            +   + L+F TG S+ P  GF  L P F I  A           LPT+ TC N L LP Y
Sbjct: 746  EELARLLQFTTGSSQLPPGGFAALCPSFQIIAAPT------HSTLPTAHTCFNQLCLPTY 799

Query: 3064 RTKEQLQTKLLYAIN 3108
             + E++   L  AI+
Sbjct: 800  DSYEEVHRMLQLAIS 814

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>P40985:HUL4_YEAST Probable E3 ubiquitin-protein ligase HUL4 - Saccharomyces cerevisiae|
            (Baker's yeast)
          Length = 892

 Score =  136 bits (342), Expect = 7e-31
 Identities = 117/426 (27%), Positives = 184/426 (43%), Gaps = 34/426 (7%)
 Frame = +1

Query: 1948 PFLAPFTIRVKIFTSQLANSKQSTASHSALTR----------HRFKIRRSRLLEDAFDQL 2097
            PF+    I++ I   ++    +  A  + L             + K+RR  +   + D L
Sbjct: 479  PFILSLGIKISIMEYEIRRIMEHEAEQAFLISLDKGKSVDVYFKIKVRRDVI---SHDSL 535

Query: 2098 SLLSEE--DLKGPIRVSFVNEHGVEEAGIDGGGIFKDFMENITRAAFDVQYGLF---KET 2262
              + E   DL   +R+ FVNE      GID GG+ K++   +T++ F+   GLF   KE+
Sbjct: 536  RCIKEHQGDLLKSLRIEFVNE-----PGIDAGGLRKEWFFLLTKSLFNPMNGLFIYIKES 590

Query: 2263 VDH---VLYPNPGSGLVHEQHLQYFHFLGSLLGKAMYEGILVDLPFATFFLSKLKEKSNF 2433
                  +  PN          L+ ++  G ++G A++   ++DL F      KL  +   
Sbjct: 591  SRSWFAIDPPNFDKSKGKNSQLELYYLFGVVMGLAIFNSTILDLQFPKALYKKLCSEPLS 650

Query: 2434 LNDLPSLDPELYRHLLFLKHYKGD----VSDLELYFVIVNNEY--------GEQAEEELL 2577
              D   L PE  R+L+ + +Y  D    V  L       NN +         E    EL 
Sbjct: 651  FEDYSELFPETSRNLIKMLNYTEDNFEDVFSLTFETTYRNNNWILNDSKSSKEYVTVELC 710

Query: 2578 PGGREMRVTNQNVITFIHLVANHRLNYQIRGQGRHFLRGFQKLIPK-EWIDMFNEHEIQL 2754
              GR + +T  N   F+       L   I  Q   F+ GF+++  +   I +FN  E++ 
Sbjct: 711  ENGRNVPITQSNKHEFVMKWVEFYLEKSIEPQYNKFVSGFKRVFAECNSIKLFNSEELER 770

Query: 2755 LISGSLES--LDIDDLRLNTNYSGGYHPDHEIIDMLWEVLKSFSSDNQKKFLKFVTGCSR 2928
            L+ G  E    D   LR  T Y GG+  D   +   WE+++S+    QKK L+FVT   R
Sbjct: 771  LVCGDEEQTKFDFKSLRSVTKYVGGFSDDSRAVCWFWEIIESWDYPLQKKLLQFVTASDR 830

Query: 2929 GPLLGFEYLDPKFCIQRAGVPGLEEH-GDRLPTSATCMNLLKLPPYRTKEQLQTKLLYAI 3105
             P  G   +  K  +       L  H  D LP + TC N + L  Y +K++L+ KLL+AI
Sbjct: 831  IPATGISTIPFKISL-------LGSHDSDDLPLAHTCFNEICLWNYSSKKKLELKLLWAI 883

Query: 3106 NSEAGF 3123
            N   G+
Sbjct: 884  NESEGY 889

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>Q8IVU3:HERC6_HUMAN Probable E3 ubiquitin-protein ligase HERC6 - Homo sapiens (Human)|
          Length = 1022

 Score =  135 bits (339), Expect = 2e-30
 Identities = 127/488 (26%), Positives = 204/488 (41%), Gaps = 31/488 (6%)
 Frame = +1

Query: 1753 KMSIDSLKSQARIGLSELLTQLQDWNSRLPFTAES--------DFYSQEATSENFVSQAI 1908
            K   D    +A +G+ + L ++   N RLP    +        +FY          +  I
Sbjct: 551  KTEQDHCNVKALLGMMKELHKVNKANCRLPENTFNINELSNLLNFYIDRGRQLFRDNHLI 610

Query: 1909 LGNTRASEIIKLAPFLAPFTIRVKIFTS------QLANSKQSTASHSALTRHR------- 2049
               T +  I    PF+     ++K+  +      Q++  K     H  + + +       
Sbjct: 611  PAETPSPVIFSDFPFIFNSLSKIKLLQADSHIKMQMSEKKAYMLMHETILQKKDEFPPSP 670

Query: 2050 ---FKIRRSRLLEDAFDQLSLLSEEDLKGPIRVSFVNEHGVEEAGIDGGGIFKDFMENIT 2220
                ++RRSRL++DA  QLS     D    + V F+NE   E  G+     F    E +T
Sbjct: 671  RFILRVRRSRLVKDALRQLSQAEATDFCKVLVVEFINEICPESGGVSSE-FFHCMFEEMT 729

Query: 2221 RAAFDVQYGLFKETVDHVLYPNPGSGL-----VHEQHLQYFHFLGSLLGKAMYEGILVDL 2385
            +     +YG+F       +YP  GS +        +  +YF F G L G +++   + +L
Sbjct: 730  KP----EYGMF-------MYPEMGSCMWFPAKPKPEKKRYFLF-GMLCGLSLFNLNVANL 777

Query: 2386 PFATFFLSKLKEKSNFLNDLPSLDPELYRHLL-FLKHYKGDVSD-LELYFVIVNNEYGEQ 2559
            PF      KL ++   L DL  L P L + L   L     D+ D L + F I    + +Q
Sbjct: 778  PFPLALYKKLLDQKPSLEDLKELSPRLGKSLQEVLDDAADDIGDALCIRFSI----HWDQ 833

Query: 2560 AEEELLPGGREMRVTNQNVITFIHLVANHRLNYQIRGQGRHFLRGFQKLIPKEWIDMFNE 2739
             + +L+P G  + V   N   ++    ++  N  ++     F RGF ++  KE +  F  
Sbjct: 834  NDVDLIPNGISIPVDQTNKRDYVSKYIDYIFNVSVKAVYEEFQRGFYRVCEKEILRHFYP 893

Query: 2740 HEIQLLISGSLESLDIDDLRLNTNYSGGYHPDHEIIDMLWEVLKSFSSDNQKKFLKFVTG 2919
             E+   I G+ +  D      N+ Y  GY   H  I + W+     + D +KKFL F+TG
Sbjct: 894  EELMTAIIGNTD-YDWKQFEQNSKYEQGYQKSHPTIQLFWKAFHKLTLDEKKKFLFFLTG 952

Query: 2920 CSRGPLLGFEYLDPKFCIQRAGVPGLEEHGDRLPTSATCMNLLKLPPYRTKEQLQTKLLY 3099
              R    G + ++  F       P      D  PTS TC N+L LP Y T E+++  L  
Sbjct: 953  RDRLHARGIQKMEIVF-----RCPETFSERDH-PTSITCHNILSLPKYSTMERMEEALQV 1006

Query: 3100 AINSEAGF 3123
            AIN+  GF
Sbjct: 1007 AINNNRGF 1014

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>Q14669:TRIPC_HUMAN Probable E3 ubiquitin-protein ligase TRIP12 - Homo sapiens (Human)|
          Length = 1992

 Score =  117 bits (293), Expect = 3e-25
 Identities = 129/474 (27%), Positives = 192/474 (40%), Gaps = 69/474 (14%)
 Frame = +1

Query: 1918 TRASEIIKLAPFLAPFTIRVKIF----------------TSQLANSKQSTASHSA--LTR 2043
            T  +E+ K  PF  PF  R  +F                T+   N   S  S  A  L R
Sbjct: 1529 TWLTELGKTCPFFFPFDTRQMLFYVTAFDRDRAMQRLLDTNPEINQSDSQDSRVAPRLDR 1588

Query: 2044 HRFKIRRSRLLEDAFDQLSLLSEEDLKGPIRVSFVNEHGVEEAGIDGGGIFKDFMENITR 2223
             +  + R  LL+ A   +  L     +  + + + NE G       G G   +F   +++
Sbjct: 1589 KKRTVNREELLKQAESVMQDLGSS--RAMLEIQYENEVGT------GLGPTLEFYALVSQ 1640

Query: 2224 AAFDVQYGLFKETVDHVLYPNP-GS--GLVHEQHLQ---------------------YFH 2331
                   GL++   + V   NP GS  G  + Q+LQ                      F 
Sbjct: 1641 ELQRADLGLWRG--EEVTLSNPKGSQEGTKYIQNLQGLFALPFGRTAKPAHIAKVKMKFR 1698

Query: 2332 FLGSLLGKAMYEGILVDLPFATFFLSKL--KEKSNFLNDLPSLDPELYRHLLFLKHY--- 2496
            FLG L+ KA+ +  LVDLP    F   +  +E S   +DL  +DP + R +  L+     
Sbjct: 1699 FLGKLMAKAIMDFRLVDLPLGLPFYKWMLRQETSLTSHDLFDIDPVVARSVYHLEDIVRQ 1758

Query: 2497 -------KGDVSDLELYFVIVNNEYGEQAEE-------------ELLPGGREMRVTNQNV 2616
                   K    +   Y +      G   E+             EL  GG+++ VT  N+
Sbjct: 1759 KKRLEQDKSQTKESLQYALETLTMNGCSVEDLGLDFTLPGFPNIELKKGGKDIPVTIHNL 1818

Query: 2617 ITFIHLVANHRLNYQIRGQGRHFLRGFQKLIPKEWIDMFNEHEIQLLISGS-LESLDIDD 2793
              ++ LV    LN  +  Q   F  GF+ + P   +  F   E+  L+ GS  ++ D   
Sbjct: 1819 EEYLRLVIFWALNEGVSRQFDSFRDGFESVFPLSHLQYFYPEELDQLLCGSKADTWDAKT 1878

Query: 2794 LRLNTNYSGGYHPDHEIIDMLWEVLKSFSSDNQKKFLKFVTGCSRGPLLGFEYLDPKFCI 2973
            L        GY  D   +  L+E+L SF ++ Q+ FL+FVTG  R P+ GF  L+P   I
Sbjct: 1879 LMECCRPDHGYTHDSRAVKFLFEILSSFDNEQQRLFLQFVTGSPRLPVGGFRSLNPPLTI 1938

Query: 2974 QRAGVPGLEEHGDRLPTSATCMNLLKLPPYRTKEQLQTKLLYAI-NSEAGFDLS 3132
             R      E   D LP+  TC+N LKLP Y + E ++ KLL A    +  F LS
Sbjct: 1939 VRKTFESTENPDDFLPSVMTCVNYLKLPDYSSIEIMREKLLIAAREGQQSFHLS 1992

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>P33202:UFD4_YEAST Ubiquitin fusion degradation protein 4 - Saccharomyces cerevisiae|
            (Baker's yeast)
          Length = 1483

 Score =  109 bits (272), Expect = 9e-23
 Identities = 85/308 (27%), Positives = 142/308 (46%), Gaps = 25/308 (8%)
 Frame = +1

Query: 2272 VLYPNPGSGLVH-EQHLQYFHFLGSLLGKAMYEGILVDLPFATFFLSKLKEKSN-FLNDL 2445
            +L+P P +   + E+ ++ F +LG+ + +++ +  ++D  F+  F   L   S   +  +
Sbjct: 1185 LLFPEPLNPFSNNEKVIELFGYLGTFVARSLLDNRILDFRFSKVFFELLHRMSTPNVTTV 1244

Query: 2446 PS-----------LDPELYRHLLFLKHYKGD---VSDLELYFVIVNNEYGEQAEEELLPG 2583
            PS           +DP L + L ++   K D   +  L L F +  N+     + EL+PG
Sbjct: 1245 PSDVETCLLMIELVDPLLAKSLKYIVANKDDNMTLESLSLTFTVPGND-----DIELIPG 1299

Query: 2584 GREMRVTNQNVITFIHLVANHRLNYQIRGQGRHFLRGFQK---------LIPKEWIDMFN 2736
            G    + + NV  +IH V +  L   I  Q + F+ GF K         L P E +D+F 
Sbjct: 1300 GCNKSLNSSNVEEYIHGVIDQILGKGIEKQLKAFIEGFSKVFSYERMLILFPDELVDIFG 1359

Query: 2737 EHEIQLLISGSLESLDIDDLRLNTNYSGGYHPDHEIIDMLWEVLKSFSSDNQKKFLKFVT 2916
              E         E   +  L  N N   GY  D  II     ++ +F    ++ FL+F+T
Sbjct: 1360 RVE---------EDWSMATLYTNLNAEHGYTMDSSIIHDFISIISAFGKHERRLFLQFLT 1410

Query: 2917 GCSRGPLLGFEYLDPKFCIQRAGVPGLEEHGDRLPTSATCMNLLKLPPYRTKEQLQTKLL 3096
            G  + P+ GF+ L+PKF +            + LP+  TC N LKLP Y +K+ ++++L 
Sbjct: 1411 GSPKLPIGGFKSLNPKFTVVLKHAEDGLTADEYLPSVMTCANYLKLPKYTSKDIMRSRLC 1470

Query: 3097 YAINSEAG 3120
             AI   AG
Sbjct: 1471 QAIEEGAG 1478

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>Q4U2R1:HERC2_MOUSE Probable E3 ubiquitin-protein ligase HERC2 - Mus musculus (Mouse)|
          Length = 4836

 Score = 95.5 bits (236), Expect = 1e-18
 Identities = 73/268 (27%), Positives = 126/268 (47%), Gaps = 3/268 (1%)
 Frame = +1

Query: 2314 HLQYFHFLGSLLGKAMYEGILVDLPFATFFLSKLKEKSNFLNDLPSLDPELYRHLLFLKH 2493
            H   F FLG LLG A+  G  + L  A     +L   S  + DL  +D +    L++++ 
Sbjct: 4531 HCSMFRFLGVLLGIAIRTGSPLSLNLAEPVWKQLAGMSLTIADLSEVDKDFIPGLMYIRD 4590

Query: 2494 YKGDVSDLE---LYFVIVNNEYGEQAEEELLPGGREMRVTNQNVITFIHLVANHRLNYQI 2664
             +    + E   L F + +      + +++    +   +T  N   ++ L  N+RL ++ 
Sbjct: 4591 NEATSEEFEAMSLPFTVPS-----ASGQDIQLSSKHTHITLDNRAEYVRLAINYRL-HEF 4644

Query: 2665 RGQGRHFLRGFQKLIPKEWIDMFNEHEIQLLISGSLESLDIDDLRLNTNYSGGYHPDHEI 2844
              Q      G  +++P   + +F  +E++ ++ GS + + +  L+    Y G   P   +
Sbjct: 4645 DEQVAAVREGMARVVPVPLLSLFTGYELETMVCGSPD-IPLHLLKSVATYKG-IEPSASL 4702

Query: 2845 IDMLWEVLKSFSSDNQKKFLKFVTGCSRGPLLGFEYLDPKFCIQRAGVPGLEEHGDRLPT 3024
            +   WEV++SFS+  +  FL+FV G +R P    ++    F IQ        +H   LP 
Sbjct: 4703 VQWFWEVMESFSNTERSLFLRFVWGRTRLPRTIADFRGRDFVIQVLDKYNPPDH--FLPE 4760

Query: 3025 SATCMNLLKLPPYRTKEQLQTKLLYAIN 3108
            S TC  LLKLP Y  K+ L+ KL YAI+
Sbjct: 4761 SYTCFFLLKLPRYSCKQVLEEKLKYAIH 4788

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>O95714:HERC2_HUMAN Probable E3 ubiquitin-protein ligase HERC2 - Homo sapiens (Human)|
          Length = 4834

 Score = 95.5 bits (236), Expect = 1e-18
 Identities = 74/268 (27%), Positives = 126/268 (47%), Gaps = 3/268 (1%)
 Frame = +1

Query: 2314 HLQYFHFLGSLLGKAMYEGILVDLPFATFFLSKLKEKSNFLNDLPSLDPELYRHLLFLKH 2493
            H   F FLG LLG A+  G  + L  A     +L   S  + DL  +D +    L++++ 
Sbjct: 4529 HSSMFRFLGVLLGIAIRTGSPLSLNLAEPVWKQLAGMSLTIADLSEVDKDFIPGLMYIRD 4588

Query: 2494 YKGDVSDLE---LYFVIVNNEYGEQAEEELLPGGREMRVTNQNVITFIHLVANHRLNYQI 2664
             +    + E   L F + +      + +++    +   +T  N   ++ L  N+RL ++ 
Sbjct: 4589 NEATSEEFEAMSLPFTVPS-----ASGQDIQLSSKHTHITLDNRAEYVRLAINYRL-HEF 4642

Query: 2665 RGQGRHFLRGFQKLIPKEWIDMFNEHEIQLLISGSLESLDIDDLRLNTNYSGGYHPDHEI 2844
              Q      G  +++P   + +F  +E++ ++ GS + + +  L+    Y G   P   +
Sbjct: 4643 DEQVAAVREGMARVVPVPLLSLFTGYELETMVCGSPD-IPLHLLKSVATYKG-IEPSASL 4700

Query: 2845 IDMLWEVLKSFSSDNQKKFLKFVTGCSRGPLLGFEYLDPKFCIQRAGVPGLEEHGDRLPT 3024
            I   WEV++SFS+  +  FL+FV G +R P    ++    F IQ        +H   LP 
Sbjct: 4701 IQWFWEVMESFSNTERSLFLRFVWGRTRLPRTIADFRGRDFVIQVLDKYNPPDH--FLPE 4758

Query: 3025 SATCMNLLKLPPYRTKEQLQTKLLYAIN 3108
            S TC  LLKLP Y  K+ L+ KL YAI+
Sbjct: 4759 SYTCFFLLKLPRYSCKQVLEEKLKYAIH 4786

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>Q10435:YDE1_SCHPO Probable ubiquitin fusion degradation protein C12B10.01c -|
            Schizosaccharomyces pombe (Fission yeast)
          Length = 1647

 Score = 93.6 bits (231), Expect = 5e-18
 Identities = 74/297 (24%), Positives = 133/297 (44%), Gaps = 11/297 (3%)
 Frame = +1

Query: 2275 LYPNP----GSGLVHEQHLQYFHFLGSLLGKAMYEGILVDLPFATFFLSKLKEKSNFLND 2442
            L+P+P    GS   +E+ +  F  LG  + +++Y+  ++ + F   F ++    +  ++ 
Sbjct: 1353 LFPSPIPLLGSSPENERKISLFFALGQFVARSIYDSRIISIQFNPLFFARNIPLT--ISS 1410

Query: 2443 LPSLDPELYRHLLFL------KHYKGDVSDLELYFVIVNNEYGEQAEEELLPGGREMRVT 2604
            +  +D  L   L +L      K+     +D++L  + ++         EL+P G    VT
Sbjct: 1411 VAKVDKGLANSLRYLEKLIPGKNPTNAETDIKLEDLHLDFTLPGFPSIELIPDGASTPVT 1470

Query: 2605 NQNVITFIHLVANHRLNYQIRGQGRHFLRGFQKLIPKEWIDMFNEHEIQLLISGSLESLD 2784
              NV  +++ V ++ +   ++ Q   F  GF  + P   + +  EHE+  L     E   
Sbjct: 1471 TFNVSDYLNYVIDYTVGKGVQQQLEAFQNGFSSVFPYTSLQVLTEHELVTLFGTVDEDWS 1530

Query: 2785 IDDLRLNTNYSGGYHPDHEIIDMLWEVLKSFSSDNQKKFLKFVTGCSRGPLLGFEYLDPK 2964
               L  +     GY  +   I  L  ++   +   Q+ FL+F+TG  + P+ GF  L+P 
Sbjct: 1531 YATLMKSIVADHGYTMESPTIQRLLTLMSQMNFQEQRDFLQFITGSRKLPIGGFAGLNPP 1590

Query: 2965 FCIQRAGVPGLEEHGDRLPTSATCMNLLKLPPYRTKEQLQTKLLYAI-NSEAGFDLS 3132
              + R          D LP+  TC+N LKLP Y + E L ++L  AI   +  F LS
Sbjct: 1591 LTVVRRLNEPPYVPDDYLPSVMTCVNYLKLPEYSSSEVLGSRLSKAILEGQGSFHLS 1647

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>Q3U487:HECD3_MOUSE Probable E3 ubiquitin-protein ligase HECTD3 - Mus musculus (Mouse)|
          Length = 861

 Score = 90.5 bits (223), Expect = 4e-17
 Identities = 88/334 (26%), Positives = 149/334 (44%), Gaps = 20/334 (5%)
 Frame = +1

Query: 2161 VEEAGIDGGGIFKDFMENITR------AAFDVQYGLFKETVDH---------VLYPNPGS 2295
            + E  ID GG F+D + +++       A   V    F  T +          +  PNP  
Sbjct: 533  IAEGIIDQGGGFRDSLADMSEELCPSSADTPVPLPFFVRTANQGNGTGEARDMYVPNPSC 592

Query: 2296 GLVHEQHLQYFHFLGSLLGKAMYEGILVDLPFATFFLSKLK-EKSNFLNDLPSLDPELYR 2472
                 +    + ++G L+G A+     + L    F   +L  E+ ++  D P++D  L +
Sbjct: 593  -----RDFAKYEWIGQLMGAALRGKEFLVLALPGFVWKQLSGEEVSWSKDFPAVDSVLVK 647

Query: 2473 HLLFLKHYKGDVSDL----ELYFVIVNNEYGEQAEEELLPGGREMRVTNQNVITFIHLVA 2640
             L  ++    +  +     EL F  V     +Q   EL+PGG  + V  ++   FI LV 
Sbjct: 648  LLEVMEGVDKETFEFKFGKELTFTTV---LSDQQVVELIPGGTGIVVEYEDRSRFIQLVR 704

Query: 2641 NHRLNYQIRGQGRHFLRGFQKLIPKEWIDMFNEHEIQLLISGSLESLDIDDLRLNTNYSG 2820
              RL  + + Q      G  K++P+  +D+    E++  + G  E + +D LR  T +  
Sbjct: 705  KARLE-ESKEQVAAMQAGLLKVVPQAVLDLLTWQELEKKVCGDPE-VTVDALRKLTRFED 762

Query: 2821 GYHPDHEIIDMLWEVLKSFSSDNQKKFLKFVTGCSRGPLLGFEYLDPKFCIQRAGVPGLE 3000
             + P    +   WE L +F+++++ +FL+FVTG SR P   + Y D      + G     
Sbjct: 763  -FEPSDTRVQYFWEALNNFTNEDRSRFLRFVTGRSRLPARIYIYPD------KLGY---- 811

Query: 3001 EHGDRLPTSATCMNLLKLPPYRTKEQLQTKLLYA 3102
            E  D LP S+TC + L LP Y + +  + KL YA
Sbjct: 812  ETTDALPESSTCSSTLFLPHYASAKVCEEKLRYA 845

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>Q5T447:HECD3_HUMAN Probable E3 ubiquitin-protein ligase HECTD3 - Homo sapiens (Human)|
          Length = 861

 Score = 89.0 bits (219), Expect = 1e-16
 Identities = 88/334 (26%), Positives = 148/334 (44%), Gaps = 20/334 (5%)
 Frame = +1

Query: 2161 VEEAGIDGGGIFKDFMENITR------AAFDVQYGLFKETVDH---------VLYPNPGS 2295
            + E  ID GG F+D + +++       A   V    F  T +          +  PNP  
Sbjct: 533  IAEGIIDQGGGFRDSLADMSEELCPSSADTPVPLPFFVRTANQGNGTGEARDMYVPNPSC 592

Query: 2296 GLVHEQHLQYFHFLGSLLGKAMYEGILVDLPFATFFLSKLK-EKSNFLNDLPSLDPELYR 2472
                 +    + ++G L+G A+     + L    F   +L  E+ ++  D P++D  L +
Sbjct: 593  -----RDFAKYEWIGQLMGAALRGKEFLVLALPGFVWKQLSGEEVSWSKDFPAVDSVLVK 647

Query: 2473 HLLFLKHYKGDVSDL----ELYFVIVNNEYGEQAEEELLPGGREMRVTNQNVITFIHLVA 2640
             L  ++    +  +     EL F  V     +Q   EL+PGG  + V   +   FI LV 
Sbjct: 648  LLEVMEGMDKETFEFKFGKELTFTTV---LSDQQVVELIPGGAGIVVGYGDRSRFIQLVQ 704

Query: 2641 NHRLNYQIRGQGRHFLRGFQKLIPKEWIDMFNEHEIQLLISGSLESLDIDDLRLNTNYSG 2820
              RL  + + Q      G  K++P+  +D+    E++  + G  E + +D LR  T +  
Sbjct: 705  KARLE-ESKEQVAAMQAGLLKVVPQAVLDLLTWQELEKKVCGDPE-VTVDALRKLTRFED 762

Query: 2821 GYHPDHEIIDMLWEVLKSFSSDNQKKFLKFVTGCSRGPLLGFEYLDPKFCIQRAGVPGLE 3000
             + P    +   WE L +F+++++ +FL+FVTG SR P   + Y D      + G     
Sbjct: 763  -FEPSDSRVQYFWEALNNFTNEDRSRFLRFVTGRSRLPARIYIYPD------KLGY---- 811

Query: 3001 EHGDRLPTSATCMNLLKLPPYRTKEQLQTKLLYA 3102
            E  D LP S+TC + L LP Y + +  + KL YA
Sbjct: 812  ETTDALPESSTCSSTLFLPHYASAKVCEEKLRYA 845

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>Q9ULT8:HECD1_HUMAN E3 ubiquitin-protein ligase HECTD1 - Homo sapiens (Human)|
          Length = 2612

 Score = 84.7 bits (208), Expect = 2e-15
 Identities = 65/212 (30%), Positives = 102/212 (48%), Gaps = 3/212 (1%)
 Frame = +1

Query: 2506 VSDLELYFVIVNNE--YGEQAEEELLPGGREMRVTNQNVITFIHLVANHRLNYQIRGQGR 2679
            + DL L F    +   YG  A + L P G +  +T  N   ++ L+ +  ++  I+ Q  
Sbjct: 2407 IEDLGLNFQFCPSSRIYGFTAVD-LKPSGEDEMITMDNAEEYVDLMFDFCMHTGIQKQME 2465

Query: 2680 HFLRGFQKLIPKEWIDMFNEHEIQLLISGSLE-SLDIDDLRLNTNYSGGYHPDHEIIDML 2856
             F  GF K+ P E +  F+  E+Q+++ G+   S   +D+   T    GY  D       
Sbjct: 2466 AFRDGFNKVFPMEKLSSFSHEEVQMILCGNQSPSWAAEDIINYTEPKLGYTRDSPGFLRF 2525

Query: 2857 WEVLKSFSSDNQKKFLKFVTGCSRGPLLGFEYLDPKFCIQRAGVPGLEEHGDRLPTSATC 3036
              VL   SSD +K FL+F TGCS  P  G   L P+  + R     ++      P+  TC
Sbjct: 2526 VRVLCGMSSDERKAFLQFTTGCSTLPPGGLANLHPRLTVVRK----VDATDASYPSVNTC 2581

Query: 3037 MNLLKLPPYRTKEQLQTKLLYAINSEAGFDLS 3132
            ++ LKLP Y ++E ++ +LL A   E GF L+
Sbjct: 2582 VHYLKLPEYSSEEIMRERLL-AATMEKGFHLN 2612

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>Q9VR91:HERC2_DROME Probable E3 ubiquitin-protein ligase HERC2 - Drosophila melanogaster|
            (Fruit fly)
          Length = 4912

 Score = 79.3 bits (194), Expect = 1e-13
 Identities = 93/356 (26%), Positives = 151/356 (42%), Gaps = 17/356 (4%)
 Frame = +1

Query: 2092 QLSLLSEEDLKGPIRVSFVNEHGVEEAGIDGGGIFKDFMENITRAAFDVQYGLFKETVD- 2268
            +L LL++E L  P RV  V   G E     GGG    + E+I     ++Q G     ++ 
Sbjct: 4539 KLPLLTQEALALPHRVWKVKFVG-ESVDDCGGG----YSESIAEMCDELQNGSVPLLINT 4593

Query: 2269 -------------HVLYPNPGSGLVHEQHLQYFHFLGSLLGKAMYEGILVDLPFATFFLS 2409
                          +L P   S L     +  F FLG L+G A+  G  + +  A     
Sbjct: 4594 PNGRGEAGANRDCFLLDPTLSSVL----QMNMFRFLGVLMGIAVRTGSPLSINLAEPVWR 4649

Query: 2410 KLKEKSNFLNDLPSLDPELYRHLLFLKHYKGD---VSDLELYFVIVNNEYGEQAEEELLP 2580
            +L  +     DL  +D +    LL +++   D    + LEL F             E+  
Sbjct: 4650 QLTGEVLRPTDLTEVDRDYVAGLLCIRNMDDDPKLFTALELPF-----STSSARGHEVPL 4704

Query: 2581 GGREMRVTNQNVITFIHLVANHRLNYQIRGQGRHFLRGFQKLIPKEWIDMFNEHEIQLLI 2760
              R   ++ +N   ++ L    RL ++   Q +    G  K+IP   + +F+  E+Q ++
Sbjct: 4705 STRYTHISPRNRAEYVRLALGFRL-HEFDEQVKAVRDGMSKVIPVPLLSLFSAAELQAMV 4763

Query: 2761 SGSLESLDIDDLRLNTNYSGGYHPDHEIIDMLWEVLKSFSSDNQKKFLKFVTGCSRGPLL 2940
             GS + + +  L+    Y G + P   ++   WEV++ F++  +  FL+FV G +R P  
Sbjct: 4764 CGSPD-IPLGLLKSVATYKG-FDPSSALVTWFWEVMEEFTNQERSLFLRFVWGRTRLPRT 4821

Query: 2941 GFEYLDPKFCIQRAGVPGLEEHGDRLPTSATCMNLLKLPPYRTKEQLQTKLLYAIN 3108
              ++    F +Q   V         LP S TC  LLK+P Y  K  L  KL YAI+
Sbjct: 4822 IADFRGRDFVLQ---VLEKNPPDHFLPESYTCFFLLKMPRYSCKAVLLEKLKYAIH 4874

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>P51592:HYD_DROME E3 ubiquitin-protein ligase hyd - Drosophila melanogaster (Fruit fly)|
          Length = 2885

 Score = 71.6 bits (174), Expect = 2e-11
 Identities = 69/293 (23%), Positives = 125/293 (42%), Gaps = 17/293 (5%)
 Frame = +1

Query: 2287 PGSGLVHEQHLQYFHFLGSLLGKAMYEGILVDLPFATFFLSKLKEKSNFLNDLPSLDPEL 2466
            P  G    + +  F  +G L+G  + +  L+ L      L  +  +    +DL   DP L
Sbjct: 2602 PRQGFASFERINAFRNIGRLIGLCLLQNELLPLFLQRHVLKYILGRKIKFHDLAFFDPAL 2661

Query: 2467 YRHLLFL------KHYKGDVSDLELYFVIVNNEYGEQAEEELLPGGREMRVTNQNVITFI 2628
            Y     +      K  +  ++ +EL FVI   +       EL+PGGR++ VT+ N+  ++
Sbjct: 2662 YESFRQIIQNAQTKEGEETINRMELCFVIDLMKEEGCGNRELIPGGRDVAVTSSNIFEYV 2721

Query: 2629 HLVANHRLNYQIRGQGRHFLRGFQKLIPKEWIDMFNEHEIQLLISGSLESLDIDDLRLNT 2808
                 +RL             G   ++P   +      +++LL++G      + D+ ++T
Sbjct: 2722 RRYTEYRLIKSQEKALEALKDGVFDVLPDNSMINLTAEDLRLLLNG------VGDINVST 2775

Query: 2809 -------NYSGGYHPDH--EIIDMLWEVLKSFSSDNQKKFLKFVTGCSRGPLL--GFEYL 2955
                   N      PD   +     W +++  +   ++  + F TG    P    GF+ L
Sbjct: 2776 LISYTTFNDESSEGPDKLLKFKKWFWSIVEKMNIMERQDLVYFWTGSPALPASEEGFQPL 2835

Query: 2956 DPKFCIQRAGVPGLEEHGDRLPTSATCMNLLKLPPYRTKEQLQTKLLYAINSE 3114
             P   I+    P  + H   LPT+ TC++ L +P Y +K  L++K+L AI S+
Sbjct: 2836 -PSVTIR----PADDSH---LPTANTCISRLYIPLYSSKSILRSKMLMAIKSK 2880

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>Q80TP3:EDD1_MOUSE E3 ubiquitin-protein ligase EDD1 - Mus musculus (Mouse)|
          Length = 2792

 Score = 71.2 bits (173), Expect = 3e-11
 Identities = 74/291 (25%), Positives = 130/291 (44%), Gaps = 13/291 (4%)
 Frame = +1

Query: 2281 PNPGSGLVHEQHLQYFHFLGSLLGKAMYEGILVDLPFATFFLSKLKEKSNFLNDLPSLDP 2460
            P PG     E  L  F  +G +LG  + +  L  +      +  L  +    +D    DP
Sbjct: 2509 PRPGKNT--EARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDP 2566

Query: 2461 ELYRHL--LFLKHYKGDV----SDLELYFVIVNNEYGEQAEEELLPGGREMRVTNQNVIT 2622
             +Y  L  L L     D     S ++L F I   +     + EL+P G  + VT QNV  
Sbjct: 2567 VMYESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVNIPVTPQNVYE 2626

Query: 2623 FIHLVANHRLNYQIRGQGRHFLR-GFQKLIPKEWIDMFNEHEIQLLISGSLESLDIDDLR 2799
            ++   A HR+   +  Q  H +R G   ++PK  ++     + +LL++G  E +++  L 
Sbjct: 2627 YVRKYAEHRM-LVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGE-VNVQMLI 2684

Query: 2800 LNTNYSGGYHPDHEII----DMLWEVLKSFSSDNQKKFLKFVTGCSRGPLL--GFEYLDP 2961
              T+++     + E +       W +++  S   ++  + F T     P    GF+ + P
Sbjct: 2685 SFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQPM-P 2743

Query: 2962 KFCIQRAGVPGLEEHGDRLPTSATCMNLLKLPPYRTKEQLQTKLLYAINSE 3114
               I+    P  ++H   LPT+ TC++ L +P Y +K+ L+ KLL AI ++
Sbjct: 2744 SITIR----PPDDQH---LPTANTCISRLYVPLYSSKQILKQKLLLAIKTK 2787

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>O95071:EDD1_HUMAN E3 ubiquitin-protein ligase EDD1 - Homo sapiens (Human)|
          Length = 2799

 Score = 71.2 bits (173), Expect = 3e-11
 Identities = 74/291 (25%), Positives = 130/291 (44%), Gaps = 13/291 (4%)
 Frame = +1

Query: 2281 PNPGSGLVHEQHLQYFHFLGSLLGKAMYEGILVDLPFATFFLSKLKEKSNFLNDLPSLDP 2460
            P PG     E  L  F  +G +LG  + +  L  +      +  L  +    +D    DP
Sbjct: 2516 PRPGKNT--EARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDP 2573

Query: 2461 ELYRHL--LFLKHYKGDV----SDLELYFVIVNNEYGEQAEEELLPGGREMRVTNQNVIT 2622
             +Y  L  L L     D     S ++L F I   +     + EL+P G  + VT QNV  
Sbjct: 2574 VMYESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVNIPVTPQNVYE 2633

Query: 2623 FIHLVANHRLNYQIRGQGRHFLR-GFQKLIPKEWIDMFNEHEIQLLISGSLESLDIDDLR 2799
            ++   A HR+   +  Q  H +R G   ++PK  ++     + +LL++G  E +++  L 
Sbjct: 2634 YVRKYAEHRM-LVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGE-VNVQMLI 2691

Query: 2800 LNTNYSGGYHPDHEII----DMLWEVLKSFSSDNQKKFLKFVTGCSRGPLL--GFEYLDP 2961
              T+++     + E +       W +++  S   ++  + F T     P    GF+ + P
Sbjct: 2692 SFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQPM-P 2750

Query: 2962 KFCIQRAGVPGLEEHGDRLPTSATCMNLLKLPPYRTKEQLQTKLLYAINSE 3114
               I+    P  ++H   LPT+ TC++ L +P Y +K+ L+ KLL AI ++
Sbjct: 2751 SITIR----PPDDQH---LPTANTCISRLYVPLYSSKQILKQKLLLAIKTK 2794

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>Q62671:EDD1_RAT E3 ubiquitin-protein ligase EDD1 - Rattus norvegicus (Rat)|
          Length = 920

 Score = 70.5 bits (171), Expect = 5e-11
 Identities = 73/291 (25%), Positives = 130/291 (44%), Gaps = 13/291 (4%)
 Frame = +1

Query: 2281 PNPGSGLVHEQHLQYFHFLGSLLGKAMYEGILVDLPFATFFLSKLKEKSNFLNDLPSLDP 2460
            P PG     E  L  F  +G +LG  + +  L  +      +  L  +    +D    DP
Sbjct: 637  PRPGKNT--EARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDP 694

Query: 2461 ELYRHL--LFLKHYKGDV----SDLELYFVIVNNEYGEQAEEELLPGGREMRVTNQNVIT 2622
             +Y  L  L L     D     S ++L F +   +     + EL+P G  + VT QNV  
Sbjct: 695  VMYESLRQLILASQSSDADAVFSAMDLAFAVDLCKEEGGGQVELIPNGVNIPVTPQNVYE 754

Query: 2623 FIHLVANHRLNYQIRGQGRHFLR-GFQKLIPKEWIDMFNEHEIQLLISGSLESLDIDDLR 2799
            ++   A HR+   +  Q  H +R G   ++PK  ++     + +LL++G  E +++  L 
Sbjct: 755  YVRKYAEHRM-LVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGE-VNVQMLI 812

Query: 2800 LNTNYSGGYHPDHEII----DMLWEVLKSFSSDNQKKFLKFVTGCSRGPLL--GFEYLDP 2961
              T+++     + E +       W +++  S   ++  + F T     P    GF+ + P
Sbjct: 813  SFTSFNDESGENAEKLLQFKRWFWSIVERMSMTERQDLVYFWTSSPSLPASEEGFQPM-P 871

Query: 2962 KFCIQRAGVPGLEEHGDRLPTSATCMNLLKLPPYRTKEQLQTKLLYAINSE 3114
               I+    P  ++H   LPT+ TC++ L +P Y +K+ L+ KLL AI ++
Sbjct: 872  SITIR----PPDDQH---LPTANTCISRLYVPLYSSKQILKQKLLLAIKTK 915

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>Q9FFQ1:RH31_ARATH DEAD-box ATP-dependent RNA helicase 31 - Arabidopsis thaliana|
            (Mouse-ear cress)
          Length = 716

 Score = 36.6 bits (83), Expect = 0.75
 Identities = 22/49 (44%), Positives = 28/49 (57%), Gaps = 1/49 (2%)
 Frame = +1

Query: 2320 QYFHFLGSLLGKAMY-EGILVDLPFATFFLSKLKEKSNFLNDLPSLDPE 2463
            QY H LG    K    EGIL+  P+  +FLS LK+     + LPS+DPE
Sbjct: 589  QYIHRLGRTGRKGKEGEGILLLAPWEEYFLSSLKDLPITKSPLPSIDPE 637

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>Q80X72:LRC15_MOUSE Leucine-rich repeat-containing protein 15 precursor - Mus musculus|
            (Mouse)
          Length = 579

 Score = 36.2 bits (82), Expect = 0.98
 Identities = 52/204 (25%), Positives = 84/204 (41%), Gaps = 8/204 (3%)
 Frame = +1

Query: 1888 NFVSQAILGNTRASEIIKLAPFLAPFTIRVKIFTSQLAN------SKQSTASHSALTRHR 2049
            N +S  IL NT  +E+ +         I +K+  ++LAN          +  H +L  ++
Sbjct: 54   NAMSLQIL-NTHITELPEDKFLNISALIALKMEKNELANIMPGAFRNLGSLRHLSLANNK 112

Query: 2050 FKIRRSRLLEDAFD-QLSLLSEEDLKGPIRVSFVNEHGVEEAGIDGGGIFKDFMENITRA 2226
             K    RL +D  + +  LLS   L       F     ++E  + G  +     E I   
Sbjct: 113  LKNLPVRLFQDVNNLETLLLSNNQLVQIQPAQFSQFSNLKELQLYGNNL-----EYIPEG 167

Query: 2227 AFDVQYGLFKETVDHVLYPNPGSGLVHEQHLQYFHFLGSLLGKAMYEGILVDLPFATF-F 2403
             FD   GL K  + +       +G  H    + F  LG+L    +YE  L D+P  TF  
Sbjct: 168  VFDHLVGLTKLNLGN-------NGFTHLSP-RVFQHLGNLQVLRLYENRLSDIPMGTFDA 219

Query: 2404 LSKLKEKSNFLNDLPSLDPELYRH 2475
            L  L+E +   N + +L P L+ +
Sbjct: 220  LGNLQELALQENQIGTLSPGLFHN 243

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>Q09573:KCC2_CAEEL Sodium/chloride cotransporter type 2 - Caenorhabditis elegans|
          Length = 1020

 Score = 34.3 bits (77), Expect = 3.7
 Identities = 24/71 (33%), Positives = 37/71 (52%), Gaps = 3/71 (4%)
 Frame = +1

Query: 2686 LRGFQKLIPKEWIDMFNEHEIQLLISGSLESLDIDDLRLNT---NYSGGYHPDHEIIDML 2856
            LRGF K +       +N H+I   ISG  +S+ I  LR NT   N+    +PD E++   
Sbjct: 693  LRGFAKTM------FYNNHQINGTISGLYQSIGIGGLRPNTILLNWPNEKNPD-ELVLFA 745

Query: 2857 WEVLKSFSSDN 2889
             E++   ++DN
Sbjct: 746  EEIIHGAANDN 756

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>P29551:EF3_PNECA Elongation factor 3 - Pneumocystis carinii|
          Length = 1042

 Score = 34.3 bits (77), Expect = 3.7
 Identities = 17/63 (26%), Positives = 26/63 (41%)
 Frame = +1

Query: 3178 LDNSLKATKTEAPTTWAQFEAQQTKGGHLWVAGGNQRRRLQQLSSHDKANVLAETVVKAS 3357
            + +S++ TK      W+    Q T  GH WV G     RLQ+    D  + L   +    
Sbjct: 950  ITHSVEFTKNLTEEVWSVQNGQMTPSGHNWVQGQGTGPRLQEQEEEDTFDALGNKIEAKK 1009

Query: 3358 KRR 3366
            K +
Sbjct: 1010 KAK 1012

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>Q5F4A1:K1333_CHICK Probable E3 ubiquitin-protein ligase-like protein KIAA1333 homolog -|
            Gallus gallus (Chicken)
          Length = 742

 Score = 33.5 bits (75), Expect = 6.4
 Identities = 25/70 (35%), Positives = 33/70 (47%)
 Frame = +1

Query: 2902 LKFVTGCSRGPLLGFEYLDPKFCIQRAGVPGLEEHGDRLPTSATCMNLLKLPPYRTKEQL 3081
            L FVTGCS  P +GF   DP+  I+   V          P     +N L+LP  RT E  
Sbjct: 677  LFFVTGCSSIPPIGF---DPEPTIKFLPV--------HYPIGNRLLNCLELPITRTYENF 725

Query: 3082 QTKLLYAINS 3111
            + K+ + I S
Sbjct: 726  KNKMEFTIRS 735

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>O67137:GYRB_AQUAE DNA gyrase subunit B - Aquifex aeolicus|
          Length = 792

 Score = 33.1 bits (74), Expect = 8.3
 Identities = 34/131 (25%), Positives = 56/131 (42%)
 Frame = +1

Query: 2110 EEDLKGPIRVSFVNEHGVEEAGIDGGGIFKDFMENITRAAFDVQYGLFKETVDHVLYPNP 2289
            EEDL+ P RV  +     EE G        D+         D +Y   +   D + Y + 
Sbjct: 619  EEDLRNPARVKEITHLMEEELG--------DYR-------VDTKYNELEGAYDIIFYDDK 663

Query: 2290 GSGLVHEQHLQYFHFLGSLLGKAMYEGILVDLPFATFFLSKLKEKSNFLNDLPSLDPELY 2469
                +  + +   +FL SL  + + EGI + LP   FF +K K + N L ++     +  
Sbjct: 664  ----LGTKTIIDVNFLSSLSYREVLEGIHLHLPVQVFFENK-KVEINSLGEIYDKFMDFA 718

Query: 2470 RHLLFLKHYKG 2502
            R  + ++ YKG
Sbjct: 719  RSGMEVQRYKG 729

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>P25997:EF3_CANAL Elongation factor 3 - Candida albicans (Yeast)|
          Length = 1049

 Score = 33.1 bits (74), Expect = 8.3
 Identities = 16/65 (24%), Positives = 29/65 (44%), Gaps = 2/65 (3%)
 Frame = +1

Query: 3178 LDNSLKATKTEAPTTWAQFEAQQTKGGHLWVAGGNQRRRLQQL--SSHDKANVLAETVVK 3351
            + +S + TK      WA  + + T  GH WV G     R+++      DK + +   +  
Sbjct: 953  ITHSAEFTKDLTEEVWAVLDGRMTPSGHNWVQGQGSGPRIEKKDDEEEDKFDAMGNKIAA 1012

Query: 3352 ASKRR 3366
            A K++
Sbjct: 1013 AKKKK 1017


  Database: uniprot_sprot.fasta.out
    Posted date:  Jul 19, 2007  5:58 PM
  Number of letters in database: 100,686,439
  Number of sequences in database:  274,295
  
Lambda     K      H
   0.318    0.134    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 274295
Number of Hits to DB: 622,888,207
Number of extensions: 13755093
Number of successful extensions: 36440
Number of sequences better than 10.0: 81
Number of HSP's gapped: 36152
Number of HSP's successfully gapped: 81
Length of query: 1167
Length of database: 100,686,439
Length adjustment: 124
Effective length of query: 1043
Effective length of database: 66,673,859
Effective search space: 69540834937
Effective search space used: 69540834937
Neighboring words threshold: 12
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)

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full-length cDNA and EST

Clone Information

BLAST Search Result