ナショナルバイオリソースプロジェクト
-Barley Genetic Resources Database-
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| Clone Name | FLbaf1h04 |
|---|---|
| Clone Library Name | barley_pub |
>Q2MHE4:HT1_ARATH Serine/threonine-protein kinase HT1 - Arabidopsis thaliana (Mouse-ear| cress) Length = 390 Score = 354 bits (908), Expect = 8e-97 Identities = 172/257 (66%), Positives = 205/257 (79%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGREVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSF 810 +FASG HSR+Y G Y R VA+KMV P + A+LE+QF SEVALL RL H NIV F Sbjct: 91 KFASGAHSRIYRGIYKQRAVAVKMVRIPTHKEETRAKLEQQFKSEVALLSRLFHPNIVQF 150 Query: 811 VAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGILH 990 +AACKKPPV+CIITEYM+ G+LR YL+++EP+S+ I+ VL+LALDI+RGM YLHSQG++H Sbjct: 151 IAACKKPPVYCIITEYMSQGNLRMYLNKKEPYSLSIETVLRLALDISRGMEYLHSQGVIH 210 Query: 991 RDLKSENVLLGEDMSVKVADFGISCLESQCGSGKGFTGTYRWMAPEMIKEKNHTRKVDVY 1170 RDLKS N+LL ++M VKVADFG SCLE+QC KG GTYRWMAPEMIKEK +TRKVDVY Sbjct: 211 RDLKSNNLLLNDEMRVKVADFGTSCLETQCREAKGNMGTYRWMAPEMIKEKPYTRKVDVY 270 Query: 1171 SFGIVLWEILTALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATNPDKR 1350 SFGIVLWE+ TAL+PF MTP QAA AVA KN RPPLPASC A++HLI +CW+ NP KR Sbjct: 271 SFGIVLWELTTALLPFQGMTPVQAAFAVAEKNERPPLPASCQPALAHLIKRCWSENPSKR 330 Query: 1351 PQFDDIVVVLEGYKEAL 1401 P F +IV VLE Y E + Sbjct: 331 PDFSNIVAVLEKYDECV 347
>P18161:KYK2_DICDI Tyrosine-protein kinase 2 - Dictyostelium discoideum (Slime mold)| Length = 410 Score = 183 bits (464), Expect = 2e-45 Identities = 111/274 (40%), Positives = 157/274 (57%), Gaps = 8/274 (2%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGREVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSF 810 + G S V+ G + G VAIK + +++ + + +F EV L + H NIV F Sbjct: 113 KVGEGAFSEVWEGWWKGIHVAIKKLKIIGDEE----QFKERFIREVQNLKKGNHQNIVMF 168 Query: 811 VAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQ----LVLQLALDIARGMSYLHSQ 978 + AC KP CIITEYMAGGSL LH + ++ LVL++A D+A G+ +LHS Sbjct: 169 IGACYKPA--CIITEYMAGGSLYNILHNPNSSTPKVKYSFPLVLKMATDMALGLLHLHSI 226 Query: 979 GILHRDLKSENVLLGEDMSVKVADFGISCLESQCGSGKGFTGTY---RWMAPEMIKEKNH 1149 I+HRDL S+N+LL E ++K++DFG+S +S+ GS G RW PE+ K H Sbjct: 227 TIVHRDLTSQNILLDELGNIKISDFGLSAEKSREGSMTMTNGGICNPRWRPPELTKNLGH 286 Query: 1150 -TRKVDVYSFGIVLWEILTALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQC 1326 + KVDVY F +V+WEILT +PFS++ Q + VA RPP+P C + L++QC Sbjct: 287 YSEKVDVYCFSLVVWEILTGEIPFSDLDGSQRSAQVAYAGLRPPIPEYCDPELKLLLTQC 346 Query: 1327 WATNPDKRPQFDDIVVVLEGYKEALDNDPSFFLS 1428 W +P+ RP F IV L KE N+P F+S Sbjct: 347 WEADPNDRPPFTYIVNKL---KEISWNNPIGFVS 377
>Q7T6Y2:YR831_MIMIV Putative serine/threonine-protein kinase/receptor R831 precursor -| Mimivirus Length = 1624 Score = 178 bits (452), Expect = 6e-44 Identities = 99/256 (38%), Positives = 148/256 (57%), Gaps = 9/256 (3%) Frame = +1 Query: 640 SGRHSRVYFGRYNGREVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSFVAA 819 +G + VY + G EVA+K++S H ++ ++ER F EV ++ LRH N+V F+AA Sbjct: 794 TGGYGEVYKSIWKGTEVAVKLISSKH----VSKDMERSFFEEVKIMTSLRHPNVVLFMAA 849 Query: 820 CKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGILHRDL 999 K P CI+ E+M+ GSL L + +P L +++A ++GM +LHS GI+HRDL Sbjct: 850 STKSPNMCIVMEFMSLGSLYDLLGNELIPEIPYALKIKMAYQASKGMHFLHSSGIVHRDL 909 Query: 1000 KSENVLLGEDMSVKVADFGISCLESQCGSGK---GFTGTYRWMAPEMIKEKNHTRKV--D 1164 KS N+LL +VKV+DFG++ ++S+ K GT W+APE++ + + D Sbjct: 910 KSLNLLLDSKWNVKVSDFGLTKVKSELDKKKTNDNIIGTIHWIAPEILNDSTEVDYILAD 969 Query: 1165 VYSFGIVLWEILTALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMS----HLISQCWA 1332 VYSFGI+LWE+LT P+ MTP A++V RPP+ A S LI QCW Sbjct: 970 VYSFGIILWELLTREQPYKGMTPAAIAVSVIRDGMRPPISDEAVTAHSIEYIDLIKQCWH 1029 Query: 1333 TNPDKRPQFDDIVVVL 1380 ++ RP F +I+ L Sbjct: 1030 SDTIIRPTFLEIMTRL 1045 Score = 163 bits (412), Expect = 3e-39 Identities = 94/258 (36%), Positives = 144/258 (55%), Gaps = 3/258 (1%) Frame = +1 Query: 643 GRHSRVYFGRYNGREVAIK-MVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSFVAA 819 G + V+ G++ G +VA+K V Q + L +F +E+A L L+H NIV+F+ A Sbjct: 1373 GSYGIVFNGKWKGVDVAVKKFVKQKLSETQLL-----EFRAEMAFLSELKHSNIVTFIGA 1427 Query: 820 CKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQG--ILHR 993 C K P CI+TEYM G+LR L + + L+L A G+ YLHS I+HR Sbjct: 1428 CIKKPNICIVTEYMRMGNLRDVLKNPD-IKITFANKLKLLYGAAMGIDYLHSSNPMIVHR 1486 Query: 994 DLKSENVLLGEDMSVKVADFGISCLESQCGSGKGFTGTYRWMAPEMIKEKNHTRKVDVYS 1173 D+K N+L+ E +VK+ADFG + ++ + GT W APE+I+ + + K DV+S Sbjct: 1487 DIKPANILVDEHFNVKIADFGFARIKED-NTTMTRCGTPCWTAPEVIRGEKYCEKADVFS 1545 Query: 1174 FGIVLWEILTALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATNPDKRP 1353 FG+V+WE+LT PF+E + ++ + L+ RP +P+ CP + LI +CW KRP Sbjct: 1546 FGVVMWEVLTGKEPFAECNFMKVSLDI-LEGGRPIIPSDCPHEFAKLIKKCWHAKAHKRP 1604 Query: 1354 QFDDIVVVLEGYKEALDN 1407 ++V L E D+ Sbjct: 1605 TMTEVVQQLMLITEQFDH 1622
>Q5UQG7:YR818_MIMIV Putative serine/threonine-protein kinase/receptor R818 precursor -| Mimivirus Length = 1651 Score = 177 bits (449), Expect = 1e-43 Identities = 95/249 (38%), Positives = 149/249 (59%), Gaps = 3/249 (1%) Frame = +1 Query: 643 GRHSRVYFGRYNGREVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSFVAAC 822 G + V G++ VA+K + D+ E F +E+A L +LRH +I+ + AC Sbjct: 1403 GSYGIVNMGKWKNINVAVKKFVKQKIDEKQMLE----FRAEIAFLSQLRHPHIILMIGAC 1458 Query: 823 KKPPVFCIITEYMAGGSLRKYLHQQEPH-SVPIQLVLQLALDIARGMSYLHSQG--ILHR 993 K P CI+TE+M GSLR + +P + I+++ Q AL G+ YLH+ I+HR Sbjct: 1459 LKRPNICIVTEFMGNGSLRNVIKTTKPEWKLKIKMLYQTAL----GIGYLHNSDPIIIHR 1514 Query: 994 DLKSENVLLGEDMSVKVADFGISCLESQCGSGKGFTGTYRWMAPEMIKEKNHTRKVDVYS 1173 D+K N+L+ + M+VK+ADFG + ++ + S GT W APE+I+ + +T KVDV+S Sbjct: 1515 DIKPSNILVDDSMNVKIADFGFARIKEE-NSVMTRCGTPCWTAPEIIRGEKYTEKVDVFS 1573 Query: 1174 FGIVLWEILTALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATNPDKRP 1353 FGIV+WE+LT PFS + ++ + L+ ARP +P+ CP+ + L+ QCW PDKRP Sbjct: 1574 FGIVMWEVLTCKEPFSGCNFMKVSMDI-LEGARPQIPSDCPIDFTKLMKQCWHAKPDKRP 1632 Query: 1354 QFDDIVVVL 1380 +D+++ L Sbjct: 1633 SMEDVIMGL 1641 Score = 155 bits (393), Expect = 4e-37 Identities = 93/258 (36%), Positives = 142/258 (55%), Gaps = 11/258 (4%) Frame = +1 Query: 640 SGRHSRVYFGRYNGREVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSFVAA 819 SG V+ + G EVA+K + + + + ER F E+ + LRH N+V F+AA Sbjct: 801 SGGSGEVFKAMWKGTEVAVKKLVNSN----ITKDAERNFKQEIHRMTSLRHPNVVLFMAA 856 Query: 820 CKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGILHRDL 999 +PP CI+ E+M+ GSL L + +P L +++A A+GM +LHS I+HRDL Sbjct: 857 STRPPNMCIVMEFMSLGSLYDLLGNELVTEIPPVLRIRIAYQAAKGMHFLHSSDIVHRDL 916 Query: 1000 KSENVLLGEDMSVKVADFGISCLESQCGSGKGFTG-----TYRWMAPEMIKEKNHTRKV- 1161 KS N+LL +VKV+DFG++ ++ GK T + +W APE++ EK + Sbjct: 917 KSLNLLLDSKWNVKVSDFGLTKIKDN-NKGKSSTKEDSVCSIQWTAPEVLSEKQDIDYIL 975 Query: 1162 -DVYSFGIVLWEILTALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMS----HLISQC 1326 DVYSFGI++WE++T L P+ ++P A+AV N RP + MS L++ C Sbjct: 976 ADVYSFGIIMWELMTRLRPYIGLSPAAIAVAVIRDNLRPEIQEEDINLMSSDYVELVNIC 1035 Query: 1327 WATNPDKRPQFDDIVVVL 1380 W + RP F +I+ L Sbjct: 1036 WHKDTMIRPSFLEIMTKL 1053
>Q7T6X2:YR826_MIMIV Putative serine/threonine-protein kinase/receptor R826 precursor -| Mimivirus Length = 1657 Score = 177 bits (448), Expect = 2e-43 Identities = 99/258 (38%), Positives = 147/258 (56%), Gaps = 8/258 (3%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGREVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSF 810 + +G V+ G + G EVA+KM+S D + ++ER F EV ++ LRH N+V F Sbjct: 791 QLGTGAFGEVHKGTWRGTEVAVKMISP---DKTITKDIERNFKDEVRVMTTLRHPNVVLF 847 Query: 811 VAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGILH 990 +AA KPP CI+ E+MA GSL L + +P L +++A ++GM +LHS GI H Sbjct: 848 MAASTKPPKMCIVMEFMALGSLHDLLKNELIPDIPFALKVKIAYQASKGMHFLHSSGITH 907 Query: 991 RDLKSENVLLGEDMSVKVADFGISCLESQCGS--GKGFTGTYRWMAPEMIKEKNHTRKV- 1161 RDLKS N+LL +VKV+DFG++ +S S + F GT +W APE++ E + Sbjct: 908 RDLKSLNLLLDIKWNVKVSDFGLTKFKSDVKSINPEKFAGTIQWTAPEILSEDREVDYIL 967 Query: 1162 -DVYSFGIVLWEILTALVPFSEMTPEQAAIAVALKNARP----PLPASCPVAMSHLISQC 1326 DVYSFGI++WE++T P+ M+P A++V N RP L + L++ C Sbjct: 968 SDVYSFGIIMWELITRDQPYFGMSPAAIAVSVIRDNYRPVISDQLRSEVAPEYIELLTSC 1027 Query: 1327 WATNPDKRPQFDDIVVVL 1380 W +P RP F +I+ L Sbjct: 1028 WHFDPTIRPTFLEIMTRL 1045 Score = 164 bits (414), Expect = 1e-39 Identities = 93/249 (37%), Positives = 146/249 (58%), Gaps = 3/249 (1%) Frame = +1 Query: 643 GRHSRVYFGRYNGREVAIK-MVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSFVAA 819 G + VY G++ +VAIK + Q +++ L E E+A L +L H NI++ V A Sbjct: 1408 GSYGVVYRGKWKNVDVAIKKFIKQKIDENHLLGIRE-----EIAFLKKLHHPNIITMVGA 1462 Query: 820 CKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHS--QGILHR 993 K P CI+TEYMA G+LR + P + +++ ++IA+G+SYLHS I+HR Sbjct: 1463 SLKKPNICIVTEYMAKGNLRDAMRTCTP-KLEWHQKIKILVNIAKGISYLHSFDPPIIHR 1521 Query: 994 DLKSENVLLGEDMSVKVADFGISCLESQCGSGKGFTGTYRWMAPEMIKEKNHTRKVDVYS 1173 D+K N+L+ E+ +VK+ADFG + ++ + + GT W APE+I+ + KVDV+S Sbjct: 1522 DIKPSNILIDENWNVKIADFGFARIKEE-NAIMTRCGTPCWTAPEIIRNDIYDEKVDVFS 1580 Query: 1174 FGIVLWEILTALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATNPDKRP 1353 FGIV+WE+LT PF + + + L++ RP +P CP + L+ +CW KRP Sbjct: 1581 FGIVMWEVLTCKEPFIGANFMKITMDI-LEDVRPKIPQDCPEEFAKLMRKCWHAKSTKRP 1639 Query: 1354 QFDDIVVVL 1380 DD+++VL Sbjct: 1640 TMDDVIIVL 1648
>Q60700:M3K12_MOUSE Mitogen-activated protein kinase kinase kinase 12 - Mus musculus| (Mouse) Length = 888 Score = 176 bits (445), Expect = 4e-43 Identities = 93/248 (37%), Positives = 138/248 (55%) Frame = +1 Query: 640 SGRHSRVYFGRYNGREVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSFVAA 819 SG V+ GR++G EVA+K V E D + L +L+H NI++F Sbjct: 166 SGAQGAVFLGRFHGEEVAVKKVRDLKETD-------------IKHLRKLKHPNIITFKGV 212 Query: 820 CKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGILHRDL 999 C + P +CI+ E+ A G L + L P V L++ ++ IA GM+YLH I+HRDL Sbjct: 213 CTQAPCYCILMEFCAQGQLYEVLRAGRP--VTPSLLVDWSMGIAGGMNYLHLHKIIHRDL 270 Query: 1000 KSENVLLGEDMSVKVADFGISCLESQCGSGKGFTGTYRWMAPEMIKEKNHTRKVDVYSFG 1179 KS N+L+ D VK++DFG S S + F GT WMAPE+I+ + + KVD++SFG Sbjct: 271 KSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFG 330 Query: 1180 IVLWEILTALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATNPDKRPQF 1359 +VLWE+LT +P+ ++ V + P+P+SCP L+ QCW + P RP F Sbjct: 331 VVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPSF 390 Query: 1360 DDIVVVLE 1383 I++ L+ Sbjct: 391 RQILLHLD 398
>Q12852:M3K12_HUMAN Mitogen-activated protein kinase kinase kinase 12 - Homo sapiens| (Human) Length = 859 Score = 176 bits (445), Expect = 4e-43 Identities = 93/248 (37%), Positives = 138/248 (55%) Frame = +1 Query: 640 SGRHSRVYFGRYNGREVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSFVAA 819 SG V+ GR++G EVA+K V E D + L +L+H NI++F Sbjct: 133 SGAQGAVFLGRFHGEEVAVKKVRDLKETD-------------IKHLRKLKHPNIITFKGV 179 Query: 820 CKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGILHRDL 999 C + P +CI+ E+ A G L + L P V L++ ++ IA GM+YLH I+HRDL Sbjct: 180 CTQAPCYCILMEFCAQGQLYEVLRAGRP--VTPSLLVDWSMGIAGGMNYLHLHKIIHRDL 237 Query: 1000 KSENVLLGEDMSVKVADFGISCLESQCGSGKGFTGTYRWMAPEMIKEKNHTRKVDVYSFG 1179 KS N+L+ D VK++DFG S S + F GT WMAPE+I+ + + KVD++SFG Sbjct: 238 KSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFG 297 Query: 1180 IVLWEILTALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATNPDKRPQF 1359 +VLWE+LT +P+ ++ V + P+P+SCP L+ QCW + P RP F Sbjct: 298 VVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPSF 357 Query: 1360 DDIVVVLE 1383 I++ L+ Sbjct: 358 RQILLHLD 365
>Q63796:M3K12_RAT Mitogen-activated protein kinase kinase kinase 12 - Rattus norvegicus| (Rat) Length = 888 Score = 175 bits (443), Expect = 6e-43 Identities = 93/248 (37%), Positives = 137/248 (55%) Frame = +1 Query: 640 SGRHSRVYFGRYNGREVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSFVAA 819 SG V+ GR++G EVA+K V E D + L +L+H NI++F Sbjct: 166 SGAQGAVFLGRFHGEEVAVKKVRDLKETD-------------IKHLRKLKHPNIITFKGV 212 Query: 820 CKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGILHRDL 999 C + P +CI+ E+ A G L + L P V L++ ++ IA GM+YLH I+HRDL Sbjct: 213 CTQAPCYCILMEFCAQGQLYEVLRAGRP--VTPSLLVDWSMGIAGGMNYLHLHKIIHRDL 270 Query: 1000 KSENVLLGEDMSVKVADFGISCLESQCGSGKGFTGTYRWMAPEMIKEKNHTRKVDVYSFG 1179 KS N+L+ D VK++DFG S S + F GT WMAPE+I+ + + KVD++SFG Sbjct: 271 KSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFG 330 Query: 1180 IVLWEILTALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATNPDKRPQF 1359 +VLWE+LT +P+ ++ V + P+P+SCP L+ QCW P RP F Sbjct: 331 VVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNRKPRNRPSF 390 Query: 1360 DDIVVVLE 1383 I++ L+ Sbjct: 391 RQILLHLD 398
>Q05609:CTR1_ARATH Serine/threonine-protein kinase CTR1 - Arabidopsis thaliana| (Mouse-ear cress) Length = 821 Score = 175 bits (443), Expect = 6e-43 Identities = 96/254 (37%), Positives = 149/254 (58%), Gaps = 4/254 (1%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGREVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSF 810 + +G V+ ++G +VA+K++ + AE +F EVA++ RLRH NIV F Sbjct: 556 KIGAGSFGTVHRAEWHGSDVAVKILMEQD----FHAERVNEFLREVAIMKRLRHPNIVLF 611 Query: 811 VAACKKPPVFCIITEYMAGGSLRKYLHQQEPHS-VPIQLVLQLALDIARGMSYLHSQG-- 981 + A +PP I+TEY++ GSL + LH+ + + L +A D+A+GM+YLH++ Sbjct: 612 MGAVTQPPNLSIVTEYLSRGSLYRLLHKSGAREQLDERRRLSMAYDVAKGMNYLHNRNPP 671 Query: 982 ILHRDLKSENVLLGEDMSVKVADFGISCLESQCG-SGKGFTGTYRWMAPEMIKEKNHTRK 1158 I+HRDLKS N+L+ + +VKV DFG+S L++ S K GT WMAPE+++++ K Sbjct: 672 IVHRDLKSPNLLVDKKYTVKVCDFGLSRLKASTFLSSKSAAGTPEWMAPEVLRDEPSNEK 731 Query: 1159 VDVYSFGIVLWEILTALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATN 1338 DVYSFG++LWE+ T P+ + P Q AV K R +P + ++ +I CW Sbjct: 732 SDVYSFGVILWELATLQQPWGNLNPAQVVAAVGFKCKRLEIPRNLNPQVAAIIEGCWTNE 791 Query: 1339 PDKRPQFDDIVVVL 1380 P KRP F I+ +L Sbjct: 792 PWKRPSFATIMDLL 805
>Q66HA1:M3K11_RAT Mitogen-activated protein kinase kinase kinase 11 - Rattus norvegicus| (Rat) Length = 850 Score = 172 bits (437), Expect = 3e-42 Identities = 101/259 (38%), Positives = 147/259 (56%), Gaps = 12/259 (4%) Frame = +1 Query: 643 GRHSRVYFGRYNGREVAIKMVSQ-PHEDDALAAELERQFASEVALLLRLRHHNIVSFVAA 819 G +VY G + G VA+K Q P ED ++ AE RQ E L L H NI++ A Sbjct: 127 GGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQ---EARLFAMLAHPNIIALKAV 183 Query: 820 CKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQG---ILH 990 C + P C++ EY AGG L + L + VP +++ A+ IARGM YLH + ++H Sbjct: 184 CLEEPNLCLVMEYAAGGPLSRALAGRR---VPPHVLVNWAVQIARGMHYLHCEALVPVIH 240 Query: 991 RDLKSENVLL-----GEDM---SVKVADFGISCLESQCGSGKGFTGTYRWMAPEMIKEKN 1146 RDLKS N+LL G+DM ++K+ DFG++ E + GTY WMAPE+IK Sbjct: 241 RDLKSNNILLLQPIEGDDMEHKTLKITDFGLA-REWHKTTQMSAAGTYAWMAPEVIKAST 299 Query: 1147 HTRKVDVYSFGIVLWEILTALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQC 1326 ++ DV+SFG++LWE+LT VP+ + A VA+ P+P++CP + L++ C Sbjct: 300 FSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADC 359 Query: 1327 WATNPDKRPQFDDIVVVLE 1383 WA +P +RP F I+ LE Sbjct: 360 WAQDPHRRPDFASILQQLE 378
>Q80XI6:M3K11_MOUSE Mitogen-activated protein kinase kinase kinase 11 - Mus musculus| (Mouse) Length = 850 Score = 172 bits (437), Expect = 3e-42 Identities = 101/259 (38%), Positives = 147/259 (56%), Gaps = 12/259 (4%) Frame = +1 Query: 643 GRHSRVYFGRYNGREVAIKMVSQ-PHEDDALAAELERQFASEVALLLRLRHHNIVSFVAA 819 G +VY G + G VA+K Q P ED ++ AE RQ E L L H NI++ A Sbjct: 127 GGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQ---EARLFAMLAHPNIIALKAV 183 Query: 820 CKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQG---ILH 990 C + P C++ EY AGG L + L + VP +++ A+ IARGM YLH + ++H Sbjct: 184 CLEEPNLCLVMEYAAGGPLSRALAGRR---VPPHVLVNWAVQIARGMHYLHCEALVPVIH 240 Query: 991 RDLKSENVLL-----GEDM---SVKVADFGISCLESQCGSGKGFTGTYRWMAPEMIKEKN 1146 RDLKS N+LL G+DM ++K+ DFG++ E + GTY WMAPE+IK Sbjct: 241 RDLKSNNILLLQPIEGDDMEHKTLKITDFGLA-REWHKTTQMSAAGTYAWMAPEVIKAST 299 Query: 1147 HTRKVDVYSFGIVLWEILTALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQC 1326 ++ DV+SFG++LWE+LT VP+ + A VA+ P+P++CP + L++ C Sbjct: 300 FSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADC 359 Query: 1327 WATNPDKRPQFDDIVVVLE 1383 WA +P +RP F I+ LE Sbjct: 360 WAQDPHRRPDFASILQQLE 378
>Q16584:M3K11_HUMAN Mitogen-activated protein kinase kinase kinase 11 - Homo sapiens| (Human) Length = 847 Score = 170 bits (431), Expect = 2e-41 Identities = 100/259 (38%), Positives = 146/259 (56%), Gaps = 12/259 (4%) Frame = +1 Query: 643 GRHSRVYFGRYNGREVAIKMVSQ-PHEDDALAAELERQFASEVALLLRLRHHNIVSFVAA 819 G +VY G + G VA+K Q P ED ++ AE RQ E L L H NI++ A Sbjct: 126 GGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQ---EARLFAMLAHPNIIALKAV 182 Query: 820 CKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQG---ILH 990 C + P C++ EY AGG L + L + VP +++ A+ IARGM YLH + ++H Sbjct: 183 CLEEPNLCLVMEYAAGGPLSRALAGRR---VPPHVLVNWAVQIARGMHYLHCEALVPVIH 239 Query: 991 RDLKSENVLL-----GEDM---SVKVADFGISCLESQCGSGKGFTGTYRWMAPEMIKEKN 1146 RDLKS N+LL +DM ++K+ DFG++ E + GTY WMAPE+IK Sbjct: 240 RDLKSNNILLLQPIESDDMEHKTLKITDFGLA-REWHKTTQMSAAGTYAWMAPEVIKAST 298 Query: 1147 HTRKVDVYSFGIVLWEILTALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQC 1326 ++ DV+SFG++LWE+LT VP+ + A VA+ P+P++CP + L++ C Sbjct: 299 FSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADC 358 Query: 1327 WATNPDKRPQFDDIVVVLE 1383 WA +P +RP F I+ LE Sbjct: 359 WAQDPHRRPDFASILQQLE 377
>Q66L42:M3K10_MOUSE Mitogen-activated protein kinase kinase kinase 10 - Mus musculus| (Mouse) Length = 940 Score = 168 bits (425), Expect = 8e-41 Identities = 97/259 (37%), Positives = 143/259 (55%), Gaps = 12/259 (4%) Frame = +1 Query: 643 GRHSRVYFGRYNGREVAIKMVS-QPHEDDALAAELERQFASEVALLLRLRHHNIVSFVAA 819 G +VY + G EVA+K P D A+ AE RQ E L L+H NI++ A Sbjct: 107 GGFGKVYRAVWRGEEVAVKAARLDPERDPAVTAEQVRQ---EARLFGALQHPNIIALRGA 163 Query: 820 CKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQG---ILH 990 C PP C++ EY GG+L + L + VP +++ A+ +ARGM+YLH+ I+H Sbjct: 164 CLSPPNLCLVMEYARGGALSRVLAGRR---VPPHVLVNWAVQVARGMNYLHNDAPVPIIH 220 Query: 991 RDLKSENVLLGE--------DMSVKVADFGISCLESQCGSGKGFTGTYRWMAPEMIKEKN 1146 RDLKS N+L+ E D +K+ DFG++ E + GTY WMAPE+I+ Sbjct: 221 RDLKSINILILEAIENHNLADTVLKITDFGLA-REWHKTTKMSAAGTYAWMAPEVIRLSL 279 Query: 1147 HTRKVDVYSFGIVLWEILTALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQC 1326 ++ DV+SFG++LWE+LT VP+ E+ A VA+ P+P++CP + L+ +C Sbjct: 280 FSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPSTCPEPFARLLEEC 339 Query: 1327 WATNPDKRPQFDDIVVVLE 1383 W +P RP F I+ LE Sbjct: 340 WDPDPHGRPDFGSILKQLE 358
>Q02779:M3K10_HUMAN Mitogen-activated protein kinase kinase kinase 10 - Homo sapiens| (Human) Length = 954 Score = 167 bits (424), Expect = 1e-40 Identities = 96/259 (37%), Positives = 143/259 (55%), Gaps = 12/259 (4%) Frame = +1 Query: 643 GRHSRVYFGRYNGREVAIKMVS-QPHEDDALAAELERQFASEVALLLRLRHHNIVSFVAA 819 G +VY + G EVA+K P +D A+ AE Q E L L+H NI++ A Sbjct: 107 GGFGKVYRALWRGEEVAVKAARLDPEKDPAVTAE---QVCQEARLFGALQHPNIIALRGA 163 Query: 820 CKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQG---ILH 990 C PP C++ EY GG+L + L + VP +++ A+ +ARGM+YLH+ I+H Sbjct: 164 CLNPPHLCLVMEYARGGALSRVLAGRR---VPPHVLVNWAVQVARGMNYLHNDAPVPIIH 220 Query: 991 RDLKSENVLLGE--------DMSVKVADFGISCLESQCGSGKGFTGTYRWMAPEMIKEKN 1146 RDLKS N+L+ E D +K+ DFG++ E + GTY WMAPE+I+ Sbjct: 221 RDLKSINILILEAIENHNLADTVLKITDFGLA-REWHKTTKMSAAGTYAWMAPEVIRLSL 279 Query: 1147 HTRKVDVYSFGIVLWEILTALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQC 1326 ++ DV+SFG++LWE+LT VP+ E+ A VA+ P+P++CP + L+ +C Sbjct: 280 FSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPSTCPEPFARLLEEC 339 Query: 1327 WATNPDKRPQFDDIVVVLE 1383 W +P RP F I+ LE Sbjct: 340 WDPDPHGRPDFGSILKRLE 358
>Q1HKZ5:M3K13_MOUSE Mitogen-activated protein kinase kinase kinase 13 - Mus musculus| (Mouse) Length = 959 Score = 167 bits (423), Expect = 1e-40 Identities = 89/248 (35%), Positives = 136/248 (54%) Frame = +1 Query: 640 SGRHSRVYFGRYNGREVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSFVAA 819 SG V+ G++ EVAIK V + +E D + L +L+H NI++F Sbjct: 175 SGAQGAVFLGKFRAEEVAIKKVREQNETD-------------IKHLRKLKHPNIIAFKGV 221 Query: 820 CKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGILHRDL 999 C + P +CII EY A G L + L + + +L++ + IA GM+YLH I+HRDL Sbjct: 222 CTQAPCYCIIMEYCAHGQLYEVL--RAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDL 279 Query: 1000 KSENVLLGEDMSVKVADFGISCLESQCGSGKGFTGTYRWMAPEMIKEKNHTRKVDVYSFG 1179 KS NVL+ +VK++DFG S S + F GT WMAPE+I+ + + KVD++SFG Sbjct: 280 KSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFG 339 Query: 1180 IVLWEILTALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATNPDKRPQF 1359 +VLWE+LT +P+ ++ V + P+P++CP L+ Q W + P RP F Sbjct: 340 VVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMKQTWQSKPRNRPSF 399 Query: 1360 DDIVVVLE 1383 ++ L+ Sbjct: 400 RQTLMHLD 407
>O43283:M3K13_HUMAN Mitogen-activated protein kinase kinase kinase 13 - Homo sapiens| (Human) Length = 966 Score = 167 bits (423), Expect = 1e-40 Identities = 89/248 (35%), Positives = 136/248 (54%) Frame = +1 Query: 640 SGRHSRVYFGRYNGREVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSFVAA 819 SG V+ G++ EVAIK V + +E D + L +L+H NI++F Sbjct: 176 SGAQGAVFLGKFRAEEVAIKKVREQNETD-------------IKHLRKLKHPNIIAFKGV 222 Query: 820 CKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGILHRDL 999 C + P +CII EY A G L + L + + +L++ + IA GM+YLH I+HRDL Sbjct: 223 CTQAPCYCIIMEYCAHGQLYEVL--RAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDL 280 Query: 1000 KSENVLLGEDMSVKVADFGISCLESQCGSGKGFTGTYRWMAPEMIKEKNHTRKVDVYSFG 1179 KS NVL+ +VK++DFG S S + F GT WMAPE+I+ + + KVD++SFG Sbjct: 281 KSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFG 340 Query: 1180 IVLWEILTALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATNPDKRPQF 1359 +VLWE+LT +P+ ++ V + P+P++CP L+ Q W + P RP F Sbjct: 341 VVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMKQTWQSKPRNRPSF 400 Query: 1360 DDIVVVLE 1383 ++ L+ Sbjct: 401 RQTLMHLD 408
>Q5R8X7:M3K13_PONPY Mitogen-activated protein kinase kinase kinase 13 - Pongo pygmaeus| (Orangutan) Length = 966 Score = 166 bits (420), Expect = 3e-40 Identities = 88/248 (35%), Positives = 136/248 (54%) Frame = +1 Query: 640 SGRHSRVYFGRYNGREVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSFVAA 819 SG V+ G++ EVAIK V + +E D + L +L+H NI++F Sbjct: 176 SGAQGAVFLGKFRAEEVAIKKVREQNETD-------------IKHLRKLKHPNIIAFKGV 222 Query: 820 CKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGILHRDL 999 C + P +CII EY A G L + L + + +L++ + IA GM+YLH I+HRDL Sbjct: 223 CTQAPCYCIIMEYCAHGQLYEVL--RAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDL 280 Query: 1000 KSENVLLGEDMSVKVADFGISCLESQCGSGKGFTGTYRWMAPEMIKEKNHTRKVDVYSFG 1179 KS NVL+ +VK++DFG S S + F GT W+APE+I+ + + KVD++SFG Sbjct: 281 KSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFAGTVAWLAPEVIRNEPVSEKVDIWSFG 340 Query: 1180 IVLWEILTALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATNPDKRPQF 1359 +VLWE+LT +P+ ++ V + P+P++CP L+ Q W + P RP F Sbjct: 341 VVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMKQTWQSKPRNRPSF 400 Query: 1360 DDIVVVLE 1383 ++ L+ Sbjct: 401 RQTLMHLD 408
>P18160:KYK1_DICDI Non-receptor tyrosine kinase spore lysis A - Dictyostelium discoideum| (Slime mold) Length = 1584 Score = 166 bits (419), Expect = 4e-40 Identities = 108/286 (37%), Positives = 156/286 (54%), Gaps = 24/286 (8%) Frame = +1 Query: 643 GRHSRVYFGRYNGREVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSFVAAC 822 G V G + +VAIK++ + D F +EV +L +LRH N+V F+ AC Sbjct: 1298 GFFGEVKRGYWRETDVAIKII---YRDQFKTKSSLVMFQNEVGILSKLRHPNVVQFLGAC 1354 Query: 823 KK--PPVFCIITEYMAGGSLRKYLH------QQEPHSVPIQLVLQLALDIARGMSYLH-- 972 CI+TE+M GGSLR++L +Q PH + L+LALDIA+GM+YLH Sbjct: 1355 TAGGEDHHCIVTEWMGGGSLRQFLTDHFNLLEQNPH-----IRLKLALDIAKGMNYLHGW 1409 Query: 973 SQGILHRDLKSENVLLG-------------EDMSVKVADFGISCLES-QCGSGKGFTGTY 1110 + ILHRDL S N+LL +D+ K++DFG+S L+ Q G Sbjct: 1410 TPPILHRDLSSRNILLDHNIDPKNPVVSSRQDIKCKISDFGLSRLKKEQASQMTQSVGCI 1469 Query: 1111 RWMAPEMIKEKNHTRKVDVYSFGIVLWEILTALVPFSEMTPEQAAIAVALKNARPPLPAS 1290 +MAPE+ K +++ K DVYS+G+VL+E+LT+ P +M P + A A ++ RPP+P + Sbjct: 1470 PYMAPEVFKGDSNSEKSDVYSYGMVLFELLTSDEPQQDMKPMKMAHLAAYESYRPPIPLT 1529 Query: 1291 CPVAMSHLISQCWATNPDKRPQFDDIVVVLEGYKEALDNDPSFFLS 1428 +++QCW +NPD RP F I+V L KE D S F S Sbjct: 1530 TSSKWKEILTQCWDSNPDSRPTFKQIIVHL---KEMEDQGVSSFAS 1572
>Q59H18:TNI3K_HUMAN Serine/threonine-protein kinase TNNI3K - Homo sapiens (Human)| Length = 936 Score = 164 bits (414), Expect = 1e-39 Identities = 99/254 (38%), Positives = 143/254 (56%), Gaps = 6/254 (2%) Frame = +1 Query: 640 SGRHSRVYFGRYNGREVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSFVAA 819 SG +VY GR + VAIK ++ F EV++L +L H ++ FV A Sbjct: 572 SGSFGKVYKGRCRNKIVAIKRYRANTYCSKSDVDM---FCREVSILCQLNHPCVIQFVGA 628 Query: 820 C-KKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHS--QGILH 990 C P F I+T+Y++GGSL LH+Q+ + +Q L +A+D+A+GM YLH+ Q I+H Sbjct: 629 CLNDPSQFAIVTQYISGGSLFSLLHEQK-RILDLQSKLIIAVDVAKGMEYLHNLTQPIIH 687 Query: 991 RDLKSENVLLGEDMSVKVADFGISCLESQCGSGKGFT--GTYRWMAPEMIKE-KNHTRKV 1161 RDL S N+LL ED VADFG S G RWMAPE+ + +T K Sbjct: 688 RDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNLRWMAPEVFTQCTRYTIKA 747 Query: 1162 DVYSFGIVLWEILTALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATNP 1341 DV+S+ + LWEILT +PF+ + P AA +A + RPP+ S P +S L+ + W P Sbjct: 748 DVFSYALCLWEILTGEIPFAHLKPAAAAADMAYHHIRPPIGYSIPKPISSLLIRGWNACP 807 Query: 1342 DKRPQFDDIVVVLE 1383 + RP+F ++V+ LE Sbjct: 808 EGRPEFSEVVMKLE 821
>Q9NYL2:MLTK_HUMAN Mitogen-activated protein kinase kinase kinase MLT - Homo sapiens| (Human) Length = 800 Score = 163 bits (413), Expect = 2e-39 Identities = 86/236 (36%), Positives = 131/236 (55%), Gaps = 3/236 (1%) Frame = +1 Query: 718 EDDALAAELERQFASEVALLLRLRHHNIVSFVAACKKPPVFCIITEYMAGGSLRKYLHQQ 897 +D +A + + E +L L H NI+ F +PP + I+TEY + GSL Y++ Sbjct: 38 QDKEVAVKKLLKIEKEAEILSVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSN 97 Query: 898 EPHSVPIQLVLQLALDIARGMSYLHSQG---ILHRDLKSENVLLGEDMSVKVADFGISCL 1068 + + ++ A D+A+GM YLH + ++HRDLKS NV++ D +K+ DFG S Sbjct: 98 RSEEMDMDHIMTWATDVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRF 157 Query: 1069 ESQCGSGKGFTGTYRWMAPEMIKEKNHTRKVDVYSFGIVLWEILTALVPFSEMTPEQAAI 1248 + + GT+ WMAPE+I+ + D YS+G+VLWE+LT VPF + Q A Sbjct: 158 HNHT-THMSLVGTFPWMAPEVIQSLPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAW 216 Query: 1249 AVALKNARPPLPASCPVAMSHLISQCWATNPDKRPQFDDIVVVLEGYKEALDNDPS 1416 V KN R +P+SCP + + L+ QCW + KRP F I+ +L E++ ND S Sbjct: 217 LVVEKNERLTIPSSCPRSFAELLHQCWEADAKKRPSFKQIISIL----ESMSNDTS 268
>Q7TQP6:TNI3K_RAT Serine/threonine-protein kinase TNNI3K - Rattus norvegicus (Rat)| Length = 835 Score = 163 bits (412), Expect = 3e-39 Identities = 100/254 (39%), Positives = 142/254 (55%), Gaps = 6/254 (2%) Frame = +1 Query: 640 SGRHSRVYFGRYNGREVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSFVAA 819 SG +VY GR + VAIK ++ F EV++L +L H +V FV A Sbjct: 471 SGSFGKVYKGRCRNKIVAIKRYRANTYCSKSDVDM---FCREVSILCQLNHPCVVQFVGA 527 Query: 820 C-KKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHS--QGILH 990 C P F I+T+Y++GGSL LH+Q+ + +Q L +A+D+A+GM YLHS Q I+H Sbjct: 528 CLDDPSQFAIVTQYISGGSLFSLLHEQK-RILDLQSKLIIAVDVAKGMEYLHSLTQPIIH 586 Query: 991 RDLKSENVLLGEDMSVKVADFGISCLESQCGSGKGFT--GTYRWMAPEMIKE-KNHTRKV 1161 RDL S N+LL ED VADFG S G RWMAPE+ + +T K Sbjct: 587 RDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNLRWMAPEVFTQCTRYTIKA 646 Query: 1162 DVYSFGIVLWEILTALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATNP 1341 DV+S+ + LWE+LT +PF+ + P AA +A + RPP+ S P +S L+ + W P Sbjct: 647 DVFSYSLCLWELLTGEIPFAHLKPAAAAADMAYHHIRPPIGYSIPKPISSLLIRGWNACP 706 Query: 1342 DKRPQFDDIVVVLE 1383 + RP+F ++V LE Sbjct: 707 EGRPEFSEVVSKLE 720
>Q9ESL4:MLTK_MOUSE Mitogen-activated protein kinase kinase kinase MLT - Mus musculus| (Mouse) Length = 802 Score = 163 bits (412), Expect = 3e-39 Identities = 83/225 (36%), Positives = 127/225 (56%), Gaps = 3/225 (1%) Frame = +1 Query: 718 EDDALAAELERQFASEVALLLRLRHHNIVSFVAACKKPPVFCIITEYMAGGSLRKYLHQQ 897 +D +A + + E +L L H NI+ F +PP + I+TEY + GSL Y++ Sbjct: 38 QDKEVAVKKLLKIEKEAEILSVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSN 97 Query: 898 EPHSVPIQLVLQLALDIARGMSYLHSQG---ILHRDLKSENVLLGEDMSVKVADFGISCL 1068 + ++ ++ A D+A+GM YLH + ++HRDLKS NV++ D +K+ DFG S Sbjct: 98 RSEEMDMEHIMTWATDVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRF 157 Query: 1069 ESQCGSGKGFTGTYRWMAPEMIKEKNHTRKVDVYSFGIVLWEILTALVPFSEMTPEQAAI 1248 + + GT+ WMAPE+I+ + D YS+G+VLWE+LT VPF + Q A Sbjct: 158 HNHT-THMSLVGTFPWMAPEVIQSLPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAW 216 Query: 1249 AVALKNARPPLPASCPVAMSHLISQCWATNPDKRPQFDDIVVVLE 1383 V KN R +P+SCP + + L+ QCW + KRP F I+ +LE Sbjct: 217 LVVEKNERLTIPSSCPRSFAELLHQCWEADAKKRPSFKQIISILE 261
>Q95UN8:M3KSL_DROME Mitogen-activated protein kinase kinase kinase - Drosophila| melanogaster (Fruit fly) Length = 1161 Score = 163 bits (412), Expect = 3e-39 Identities = 93/259 (35%), Positives = 139/259 (53%), Gaps = 11/259 (4%) Frame = +1 Query: 640 SGRHSRVYFGRYNGREVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSFVAA 819 SG +V+ G Y+G EVAIK+ Q EDD + E L L+H NI + Sbjct: 150 SGGFCKVHRGYYDGEEVAIKIAHQTGEDDM--QRMRDNVLQEAKLFWALKHENIAALRGV 207 Query: 820 CKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQG---ILH 990 C + C++ EY GGSL + L + +P +++ A+ IARGM+YLH++ I+H Sbjct: 208 CLNTKL-CLVMEYARGGSLNRILAGK----IPPDVLVNWAIQIARGMNYLHNEAPMSIIH 262 Query: 991 RDLKSENVLLGEDM--------SVKVADFGISCLESQCGSGKGFTGTYRWMAPEMIKEKN 1146 RDLKS NVL+ E + ++K+ DFG++ E GTY WM PE+I Sbjct: 263 RDLKSSNVLIYEAIEGNHLQQKTLKITDFGLA-REMYNTQRMSAAGTYAWMPPEVISVST 321 Query: 1147 HTRKVDVYSFGIVLWEILTALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQC 1326 +++ DV+S+G++LWE++T P+ P A VA+ P+P +CP L+ C Sbjct: 322 YSKFSDVWSYGVLLWELITGETPYKGFDPLSVAYGVAVNTLTLPIPKTCPETWGALMKSC 381 Query: 1327 WATNPDKRPQFDDIVVVLE 1383 W T+P KRP F +I+ LE Sbjct: 382 WQTDPHKRPGFKEILKQLE 400
>Q5GIG6:TNI3K_MOUSE Serine/threonine-protein kinase TNNI3K - Mus musculus (Mouse)| Length = 834 Score = 160 bits (406), Expect = 1e-38 Identities = 99/254 (38%), Positives = 141/254 (55%), Gaps = 6/254 (2%) Frame = +1 Query: 640 SGRHSRVYFGRYNGREVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSFVAA 819 SG +VY GR + VAIK ++ F EV++L +L H +V FV A Sbjct: 470 SGSFGKVYKGRCRNKIVAIKRYRANTYCSKSDVDM---FCREVSILCQLNHPCVVQFVGA 526 Query: 820 C-KKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHS--QGILH 990 C P F I+T+Y++GGSL LH+Q+ + +Q L +A+D+A+GM YLHS Q I+H Sbjct: 527 CLDDPSQFAIVTQYISGGSLFSLLHEQK-RILDLQSKLIIAVDVAKGMEYLHSLTQPIIH 585 Query: 991 RDLKSENVLLGEDMSVKVADFGISCLESQCGSGKGFT--GTYRWMAPEMIKE-KNHTRKV 1161 RDL S N+LL ED VADFG S G RWMAPE+ + +T K Sbjct: 586 RDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNLRWMAPEVFTQCTRYTIKA 645 Query: 1162 DVYSFGIVLWEILTALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATNP 1341 DV+S+ + LWE+L +PF+ + P AA +A + RPP+ S P +S L+ + W P Sbjct: 646 DVFSYALCLWELLIGEIPFAHLKPAAAAADMAYHHIRPPIGYSIPKPISSLLMRGWNACP 705 Query: 1342 DKRPQFDDIVVVLE 1383 + RP+F ++V LE Sbjct: 706 EGRPEFSEVVRKLE 719
>Q7T2V3:M3K10_XENLA Mitogen-activated protein kinase kinase kinase 10 - Xenopus laevis| (African clawed frog) Length = 1005 Score = 160 bits (406), Expect = 1e-38 Identities = 92/255 (36%), Positives = 140/255 (54%), Gaps = 12/255 (4%) Frame = +1 Query: 643 GRHSRVYFGRYNGREVAIKMVSQ-PHEDDALAAELERQFASEVALLLRLRHHNIVSFVAA 819 G +VY G + EVA+K V P ED + AE RQ E + L H NI++ Sbjct: 127 GGFGKVYKGLWRDEEVAVKAVRHDPDEDINVTAENVRQ---EAKIFCMLCHPNIIALTGV 183 Query: 820 CKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGI---LH 990 C KPP C++ EY GG L + L ++ VP +++ A+ IA+GM+YLH++ I +H Sbjct: 184 CLKPPHLCLVMEYARGGPLHRALAGKK---VPAHVLVNWAVQIAKGMTYLHNEAIVPIIH 240 Query: 991 RDLKSENVLLGE--------DMSVKVADFGISCLESQCGSGKGFTGTYRWMAPEMIKEKN 1146 RDL S N+L+ E + ++ + DFG++ E Q + GTY WMAPE+I+ Sbjct: 241 RDLGSSNILILEKAENDDLFNKTLNITDFGLA-REWQKTTKMSAAGTYAWMAPEVIRLSL 299 Query: 1147 HTRKVDVYSFGIVLWEILTALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQC 1326 ++ DV+SFG++LWE+LT VP+ E+ A VA+ P+P++CP ++ C Sbjct: 300 FSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPSTCPEPFVRILEAC 359 Query: 1327 WATNPDKRPQFDDIV 1371 W +P RP F I+ Sbjct: 360 WDPDPHSRPTFSCIL 374
>Q5TCX8:M3KL4_HUMAN Mitogen-activated protein kinase kinase kinase - Homo sapiens (Human)| Length = 1036 Score = 158 bits (399), Expect = 8e-38 Identities = 100/294 (34%), Positives = 151/294 (51%), Gaps = 24/294 (8%) Frame = +1 Query: 592 ALERRPLKARDPGRFASGRHSRVYFGRYNGREVAIKMVSQ-PHEDDALAAELERQFASEV 768 A ER LK +G +VY + G+EVA+K Q P +D A AAE R+ E Sbjct: 120 AFERLELKEL----IGAGGFGQVYRATWQGQEVAVKAARQDPEQDAAAAAESVRR---EA 172 Query: 769 ALLLRLRHHNIVSFVAACKKPPVFCIITEYMAGGSLRKYLHQ------------QEPHSV 912 L LRH NI+ C + P C++ E+ GG+L + L + + Sbjct: 173 RLFAMLRHPNIIELRGVCLQQPHLCLVLEFARGGALNRALAAANAAPDPRAPGPRRARRI 232 Query: 913 PIQLVLQLALDIARGMSYLHSQG---ILHRDLKSENVLLGEDM--------SVKVADFGI 1059 P +++ A+ IARGM YLH + ILHRDLKS N+LL E + ++K+ DFG+ Sbjct: 233 PPHVLVNWAVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGL 292 Query: 1060 SCLESQCGSGKGFTGTYRWMAPEMIKEKNHTRKVDVYSFGIVLWEILTALVPFSEMTPEQ 1239 + E + GTY WMAPE+IK ++ D++S+G++LWE+LT VP+ + Sbjct: 293 A-REWHRTTKMSTAGTYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDGLA 351 Query: 1240 AAIAVALKNARPPLPASCPVAMSHLISQCWATNPDKRPQFDDIVVVLEGYKEAL 1401 A VA+ P+P++CP + L+ +CW +P RP F I+ L + A+ Sbjct: 352 VAYGVAVNKLTLPIPSTCPEPFAKLMKECWQQDPHIRPSFALILEQLTAIEGAV 405
>P80192:M3K9_HUMAN Mitogen-activated protein kinase kinase kinase 9 - Homo sapiens| (Human) Length = 1104 Score = 155 bits (392), Expect = 5e-37 Identities = 93/264 (35%), Positives = 143/264 (54%), Gaps = 12/264 (4%) Frame = +1 Query: 643 GRHSRVYFGRYNGREVAIKMVSQ-PHEDDALAAELERQFASEVALLLRLRHHNIVSFVAA 819 G +VY + G EVA+K P ED + E RQ E L L+H NI++ Sbjct: 153 GGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQ---EAKLFAMLKHPNIIALRGV 209 Query: 820 CKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGI---LH 990 C K P C++ E+ GG L + L + +P +++ A+ IARGM+YLH + I +H Sbjct: 210 CLKEPNLCLVMEFARGGPLNRVLSGKR---IPPDILVNWAVQIARGMNYLHDEAIVPIIH 266 Query: 991 RDLKSENVLLGE-----DMS---VKVADFGISCLESQCGSGKGFTGTYRWMAPEMIKEKN 1146 RDLKS N+L+ + D+S +K+ DFG++ E + GTY WMAPE+I+ Sbjct: 267 RDLKSSNILILQKVENGDLSNKILKITDFGLA-REWHRTTKMSAAGTYAWMAPEVIRASM 325 Query: 1147 HTRKVDVYSFGIVLWEILTALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQC 1326 ++ DV+S+G++LWE+LT VPF + A VA+ P+P++CP + L+ C Sbjct: 326 FSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDC 385 Query: 1327 WATNPDKRPQFDDIVVVLEGYKEA 1398 W +P RP F +I+ L +E+ Sbjct: 386 WNPDPHSRPSFTNILDQLTTIEES 409
>Q3U1V8:M3K9_MOUSE Mitogen-activated protein kinase kinase kinase 9 - Mus musculus| (Mouse) Length = 1077 Score = 154 bits (388), Expect = 2e-36 Identities = 93/264 (35%), Positives = 141/264 (53%), Gaps = 12/264 (4%) Frame = +1 Query: 643 GRHSRVYFGRYNGREVAIKMVSQ-PHEDDALAAELERQFASEVALLLRLRHHNIVSFVAA 819 G +VY + G EVA+K P ED + E RQ E L L+H NI++ Sbjct: 146 GGFGKVYRAFWAGDEVAVKAARHDPDEDISQTIENVRQ---EAKLFAMLKHPNIIALRGV 202 Query: 820 CKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGI---LH 990 C K P C++ E+ GG L + L + +P +++ A+ IARGM+YLH + I +H Sbjct: 203 CLKEPNLCLVMEFARGGPLNRVLSGKR---IPPDILVNWAVQIARGMNYLHDEAIVPIIH 259 Query: 991 RDLKSENVLLGE-----DMSVKV---ADFGISCLESQCGSGKGFTGTYRWMAPEMIKEKN 1146 RDLKS N+L+ + D+S K+ DFG++ E + GTY WMAPE+I+ Sbjct: 260 RDLKSSNILILQKVENGDLSNKILEITDFGLA-REWHRTTKMSAAGTYAWMAPEVIRASM 318 Query: 1147 HTRKVDVYSFGIVLWEILTALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQC 1326 ++ DV+S+G++LWE+LT VPF + A VA+ P+P++CP + L+ C Sbjct: 319 FSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDC 378 Query: 1327 WATNPDKRPQFDDIVVVLEGYKEA 1398 W +P RP F I+ L +E+ Sbjct: 379 WNPDPHSRPSFTSILDQLTTIEES 402
>P10533:RMIL_AVII1 Serine/threonine-protein kinase-transforming protein Rmil - Avian| retrovirus IC10 Length = 367 Score = 152 bits (383), Expect = 6e-36 Identities = 93/261 (35%), Positives = 154/261 (59%), Gaps = 10/261 (3%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGREVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSF 810 R SG VY G+++G +VA+KM++ A + + F +EV +L + RH NI+ F Sbjct: 72 RIGSGSFGTVYKGKWHG-DVAVKMLNVT----APTPQQLQAFKNEVGVLRKTRHVNILLF 126 Query: 811 VAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGILH 990 + KP + I+T++ G SL +LH E I+L+ +A A+GM YLH++ I+H Sbjct: 127 MGYSTKPQL-AIVTQWCEGSSLYHHLHIIETKFEMIKLI-DIARQTAQGMDYLHAKSIIH 184 Query: 991 RDLKSENVLLGEDMSVKVADFGISCLESQCGSGKGF---TGTYRWMAPEMIK--EKN-HT 1152 RDLKS N+ L ED++VK+ DFG++ ++S+ F +G+ WMAPE+I+ +KN ++ Sbjct: 185 RDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYS 244 Query: 1153 RKVDVYSFGIVLWEILTALVPFSEMTPEQAAIAVALKNARPP----LPASCPVAMSHLIS 1320 + DVY+FGIVL+E++T +P+S + I + + P + ++CP AM L++ Sbjct: 245 FQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMA 304 Query: 1321 QCWATNPDKRPQFDDIVVVLE 1383 +C D+RP F I+ +E Sbjct: 305 ECLKKKRDERPLFPQILASIE 325
>P27966:RMIL_AVEVR Serine/threonine-protein kinase-transforming protein Rmil - Avian| rous-associated virus type 1 Length = 450 Score = 152 bits (383), Expect = 6e-36 Identities = 93/261 (35%), Positives = 154/261 (59%), Gaps = 10/261 (3%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGREVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSF 810 R SG VY G+++G +VA+KM++ A + + F +EV +L + RH NI+ F Sbjct: 88 RIGSGSFGTVYKGKWHG-DVAVKMLNVT----APTPQQLQAFKNEVGVLRKTRHVNILLF 142 Query: 811 VAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGILH 990 + KP + I+T++ G SL +LH E I+L+ +A A+GM YLH++ I+H Sbjct: 143 MGYSTKPQL-AIVTQWCEGSSLYHHLHIIETKFEMIKLI-DIARQTAQGMDYLHAKSIIH 200 Query: 991 RDLKSENVLLGEDMSVKVADFGISCLESQCGSGKGF---TGTYRWMAPEMIK--EKN-HT 1152 RDLKS N+ L ED++VK+ DFG++ ++S+ F +G+ WMAPE+I+ +KN ++ Sbjct: 201 RDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYS 260 Query: 1153 RKVDVYSFGIVLWEILTALVPFSEMTPEQAAIAVALKNARPP----LPASCPVAMSHLIS 1320 + DVY+FGIVL+E++T +P+S + I + + P + ++CP AM L++ Sbjct: 261 FQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMA 320 Query: 1321 QCWATNPDKRPQFDDIVVVLE 1383 +C D+RP F I+ +E Sbjct: 321 ECLKKKRDERPLFPQILASIE 341
>P28028:BRAF1_MOUSE B-Raf proto-oncogene serine/threonine-protein kinase - Mus musculus| (Mouse) Length = 804 Score = 152 bits (383), Expect = 6e-36 Identities = 93/261 (35%), Positives = 154/261 (59%), Gaps = 10/261 (3%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGREVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSF 810 R SG VY G+++G +VA+KM++ A + + F +EV +L + RH NI+ F Sbjct: 499 RIGSGSFGTVYKGKWHG-DVAVKMLNVT----APTPQQLQAFKNEVGVLRKTRHVNILLF 553 Query: 811 VAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGILH 990 + KP + I+T++ G SL +LH E I+L+ +A A+GM YLH++ I+H Sbjct: 554 MGYSTKPQL-AIVTQWCEGSSLYHHLHIIETKFEMIKLI-DIARQTAQGMDYLHAKSIIH 611 Query: 991 RDLKSENVLLGEDMSVKVADFGISCLESQCGSGKGF---TGTYRWMAPEMIK--EKN-HT 1152 RDLKS N+ L ED++VK+ DFG++ ++S+ F +G+ WMAPE+I+ +KN ++ Sbjct: 612 RDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYS 671 Query: 1153 RKVDVYSFGIVLWEILTALVPFSEMTPEQAAIAVALKNARPP----LPASCPVAMSHLIS 1320 + DVY+FGIVL+E++T +P+S + I + + P + ++CP AM L++ Sbjct: 672 FQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMA 731 Query: 1321 QCWATNPDKRPQFDDIVVVLE 1383 +C D+RP F I+ +E Sbjct: 732 ECLKKKRDERPLFPQILASIE 752
>P15056:BRAF1_HUMAN B-Raf proto-oncogene serine/threonine-protein kinase - Homo sapiens| (Human) Length = 766 Score = 152 bits (383), Expect = 6e-36 Identities = 93/261 (35%), Positives = 154/261 (59%), Gaps = 10/261 (3%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGREVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSF 810 R SG VY G+++G +VA+KM++ A + + F +EV +L + RH NI+ F Sbjct: 462 RIGSGSFGTVYKGKWHG-DVAVKMLNVT----APTPQQLQAFKNEVGVLRKTRHVNILLF 516 Query: 811 VAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGILH 990 + KP + I+T++ G SL +LH E I+L+ +A A+GM YLH++ I+H Sbjct: 517 MGYSTKPQL-AIVTQWCEGSSLYHHLHIIETKFEMIKLI-DIARQTAQGMDYLHAKSIIH 574 Query: 991 RDLKSENVLLGEDMSVKVADFGISCLESQCGSGKGF---TGTYRWMAPEMIK--EKN-HT 1152 RDLKS N+ L ED++VK+ DFG++ ++S+ F +G+ WMAPE+I+ +KN ++ Sbjct: 575 RDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYS 634 Query: 1153 RKVDVYSFGIVLWEILTALVPFSEMTPEQAAIAVALKNARPP----LPASCPVAMSHLIS 1320 + DVY+FGIVL+E++T +P+S + I + + P + ++CP AM L++ Sbjct: 635 FQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMA 694 Query: 1321 QCWATNPDKRPQFDDIVVVLE 1383 +C D+RP F I+ +E Sbjct: 695 ECLKKKRDERPLFPQILASIE 715
>P34908:BRAF1_COTJA B-Raf proto-oncogene serine/threonine-protein kinase - Coturnix| coturnix japonica (Japanese quail) Length = 807 Score = 152 bits (383), Expect = 6e-36 Identities = 93/261 (35%), Positives = 154/261 (59%), Gaps = 10/261 (3%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGREVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSF 810 R SG VY G+++G +VA+KM++ A + + F +EV +L + RH NI+ F Sbjct: 502 RIGSGSFGTVYKGKWHG-DVAVKMLNVT----APTPQQLQAFKNEVGVLRKTRHVNILLF 556 Query: 811 VAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGILH 990 + KP + I+T++ G SL +LH E I+L+ +A A+GM YLH++ I+H Sbjct: 557 MGYSTKPQL-AIVTQWCEGSSLYHHLHIIETKFEMIKLI-DIARQTAQGMDYLHAKSIIH 614 Query: 991 RDLKSENVLLGEDMSVKVADFGISCLESQCGSGKGF---TGTYRWMAPEMIK--EKN-HT 1152 RDLKS N+ L ED++VK+ DFG++ ++S+ F +G+ WMAPE+I+ +KN ++ Sbjct: 615 RDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYS 674 Query: 1153 RKVDVYSFGIVLWEILTALVPFSEMTPEQAAIAVALKNARPP----LPASCPVAMSHLIS 1320 + DVY+FGIVL+E++T +P+S + I + + P + ++CP AM L++ Sbjct: 675 FQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMA 734 Query: 1321 QCWATNPDKRPQFDDIVVVLE 1383 +C D+RP F I+ +E Sbjct: 735 ECLKKKRDERPLFPQILASIE 755
>Q04982:BRAF1_CHICK B-Raf proto-oncogene serine/threonine-protein kinase - Gallus gallus| (Chicken) Length = 806 Score = 152 bits (383), Expect = 6e-36 Identities = 93/261 (35%), Positives = 154/261 (59%), Gaps = 10/261 (3%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGREVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSF 810 R SG VY G+++G +VA+KM++ A + + F +EV +L + RH NI+ F Sbjct: 502 RIGSGSFGTVYKGKWHG-DVAVKMLNVT----APTPQQLQAFKNEVGVLRKTRHVNILLF 556 Query: 811 VAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGILH 990 + KP + I+T++ G SL +LH E I+L+ +A A+GM YLH++ I+H Sbjct: 557 MGYSTKPQL-AIVTQWCEGSSLYHHLHIIETKFEMIKLI-DIARQTAQGMDYLHAKSIIH 614 Query: 991 RDLKSENVLLGEDMSVKVADFGISCLESQCGSGKGF---TGTYRWMAPEMIK--EKN-HT 1152 RDLKS N+ L ED++VK+ DFG++ ++S+ F +G+ WMAPE+I+ +KN ++ Sbjct: 615 RDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYS 674 Query: 1153 RKVDVYSFGIVLWEILTALVPFSEMTPEQAAIAVALKNARPP----LPASCPVAMSHLIS 1320 + DVY+FGIVL+E++T +P+S + I + + P + ++CP AM L++ Sbjct: 675 FQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMA 734 Query: 1321 QCWATNPDKRPQFDDIVVVLE 1383 +C D+RP F I+ +E Sbjct: 735 ECLKKKRDERPLFPQILASIE 755
>P17713:STK_HYDAT Tyrosine-protein kinase STK - Hydra attenuata (Hydra) (Hydra| vulgaris) Length = 509 Score = 147 bits (371), Expect = 1e-34 Identities = 88/257 (34%), Positives = 140/257 (54%), Gaps = 4/257 (1%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGR-EVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVS 807 + +G+ V+ G +N +VA+K + A F E ++ +LRH ++V Sbjct: 245 KLGAGQFGEVWAGVWNNTTQVAVKTLKPGTMSPA-------SFLDEAGVMKKLRHKHLVQ 297 Query: 808 FVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGIL 987 A C I+TEYM+GGSL YL + E ++ + ++ +A +A GM++L +QG + Sbjct: 298 LYAICSDREPIYIVTEYMSGGSLLDYLSKGEGVNLQLPTLIDMAAQVASGMAFLEAQGYI 357 Query: 988 HRDLKSENVLLGEDMSVKVADFGISCL--ESQCGSGKGFTGTYRWMAPEMIKEKNHTRKV 1161 HRDL + N+L+GE+ KVADFG++ L + + + +G +W APE T K Sbjct: 358 HRDLAARNILVGENYICKVADFGLARLIEDDEYTAHEGAKFPIKWTAPEAALYNRFTIKS 417 Query: 1162 DVYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATN 1338 DV+SFGI++ EI+T +P+ MT Q IA K R P+ CP + +++ Q W + Sbjct: 418 DVWSFGILMAEIVTKGRIPYPGMTNAQ-TIAEVEKGYRMPIMPGCPEPLYNIMLQTWNKD 476 Query: 1339 PDKRPQFDDIVVVLEGY 1389 P+ RP FD + VLE Y Sbjct: 477 PENRPTFDYLQGVLEDY 493
>P11345:RAF1_RAT RAF proto-oncogene serine/threonine-protein kinase - Rattus| norvegicus (Rat) Length = 648 Score = 145 bits (367), Expect = 4e-34 Identities = 92/267 (34%), Positives = 154/267 (57%), Gaps = 10/267 (3%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGREVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSF 810 R SG VY G+++G +VA+K++ D +L+ F +EVA+L + RH NI+ F Sbjct: 354 RIGSGSFGTVYKGKWHG-DVAVKILKVV---DPTPEQLQA-FRNEVAVLRKTRHVNILLF 408 Query: 811 VAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGILH 990 + K + I+T++ G SL K+LH QE QL+ +A A+GM YLH++ I+H Sbjct: 409 MGYMTKDNL-AIVTQWCEGSSLYKHLHVQETKFQMFQLI-DIARQTAQGMDYLHAKNIIH 466 Query: 991 RDLKSENVLLGEDMSVKVADFGISCLESQCGSGKGF---TGTYRWMAPEMIKEKNH---T 1152 RD+KS N+ L E ++VK+ DFG++ ++S+ + TG+ WMAPE+I+ +++ + Sbjct: 467 RDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFS 526 Query: 1153 RKVDVYSFGIVLWEILTALVPFSEMTPEQAAIAVALKNARPP----LPASCPVAMSHLIS 1320 + DVYS+GIVL+E++T +P+S + I + + P L +CP AM L++ Sbjct: 527 FQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSRLYKNCPKAMKRLVA 586 Query: 1321 QCWATNPDKRPQFDDIVVVLEGYKEAL 1401 C ++RP F I+ +E + +L Sbjct: 587 DCVKKVKEERPLFPQILSSIELLQHSL 613
>Q5R5M7:RAF1_PONPY RAF proto-oncogene serine/threonine-protein kinase - Pongo pygmaeus| (Orangutan) Length = 648 Score = 145 bits (366), Expect = 5e-34 Identities = 91/267 (34%), Positives = 152/267 (56%), Gaps = 10/267 (3%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGREVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSF 810 R SG VY G+++G +VA+K++ E + F +EVA+L + RH NI+ F Sbjct: 354 RIGSGSFGTVYKGKWHG-DVAVKILKVVDP----TPEQFQAFRNEVAVLRKTRHVNILLF 408 Query: 811 VAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGILH 990 + K + I+T++ G SL K+LH QE QL+ +A A+GM YLH++ I+H Sbjct: 409 MGYMTKDNL-AIVTQWCEGSSLYKHLHVQETKFQMFQLI-DIARQTAQGMDYLHAKNIIH 466 Query: 991 RDLKSENVLLGEDMSVKVADFGISCLESQCGSGKGF---TGTYRWMAPEMIKEKNH---T 1152 RD+KS N+ L E ++VK+ DFG++ ++S+ + TG+ WMAPE+I+ +++ + Sbjct: 467 RDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFS 526 Query: 1153 RKVDVYSFGIVLWEILTALVPFSEMTPEQAAIAVALKNARPP----LPASCPVAMSHLIS 1320 + DVYS+GIVL+E++T +P+S + I + + P L +CP AM L++ Sbjct: 527 FQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVA 586 Query: 1321 QCWATNPDKRPQFDDIVVVLEGYKEAL 1401 C ++RP F I+ +E + +L Sbjct: 587 DCVKKVKEERPLFPQILSSIELLQHSL 613
>P04049:RAF1_HUMAN RAF proto-oncogene serine/threonine-protein kinase - Homo sapiens| (Human) Length = 648 Score = 145 bits (366), Expect = 5e-34 Identities = 91/267 (34%), Positives = 152/267 (56%), Gaps = 10/267 (3%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGREVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSF 810 R SG VY G+++G +VA+K++ E + F +EVA+L + RH NI+ F Sbjct: 354 RIGSGSFGTVYKGKWHG-DVAVKILKVVDP----TPEQFQAFRNEVAVLRKTRHVNILLF 408 Query: 811 VAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGILH 990 + K + I+T++ G SL K+LH QE QL+ +A A+GM YLH++ I+H Sbjct: 409 MGYMTKDNL-AIVTQWCEGSSLYKHLHVQETKFQMFQLI-DIARQTAQGMDYLHAKNIIH 466 Query: 991 RDLKSENVLLGEDMSVKVADFGISCLESQCGSGKGF---TGTYRWMAPEMIKEKNH---T 1152 RD+KS N+ L E ++VK+ DFG++ ++S+ + TG+ WMAPE+I+ +++ + Sbjct: 467 RDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFS 526 Query: 1153 RKVDVYSFGIVLWEILTALVPFSEMTPEQAAIAVALKNARPP----LPASCPVAMSHLIS 1320 + DVYS+GIVL+E++T +P+S + I + + P L +CP AM L++ Sbjct: 527 FQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVA 586 Query: 1321 QCWATNPDKRPQFDDIVVVLEGYKEAL 1401 C ++RP F I+ +E + +L Sbjct: 587 DCVKKVKEERPLFPQILSSIELLQHSL 613
>P27446:FYN_XIPHE Proto-oncogene tyrosine-protein kinase FYN - Xiphophorus helleri| Length = 537 Score = 145 bits (366), Expect = 5e-34 Identities = 84/262 (32%), Positives = 145/262 (55%), Gaps = 4/262 (1%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGR-EVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVS 807 R +G+ V+ G +NG +VA+K + + ++ E F E ++ +LRH +V Sbjct: 276 RLGNGQFGEVWMGTWNGTTKVAVKTL----KPGTMSPE---SFLEEAQIMKKLRHDKLVQ 328 Query: 808 FVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGIL 987 A + P++ I+TEYM+ GSL +L E ++ + ++ +A +A GM+Y+ + Sbjct: 329 LYAVVSEEPIY-IVTEYMSKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYI 387 Query: 988 HRDLKSENVLLGEDMSVKVADFGISCL--ESQCGSGKGFTGTYRWMAPEMIKEKNHTRKV 1161 HRDL+S N+L+G+++ K+ADFG++ L +++ + +G +W APE T K Sbjct: 388 HRDLRSANILVGDNLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKS 447 Query: 1162 DVYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATN 1338 DV+SFGI+L E++T VP+ M + V + R P P CP ++ L+ QCW + Sbjct: 448 DVWSFGILLTELVTKGRVPYPGMNNREVLEQVE-RGYRMPCPQDCPASLHELMLQCWKKD 506 Query: 1339 PDKRPQFDDIVVVLEGYKEALD 1404 P++RP F+ + LE Y A + Sbjct: 507 PEERPTFEYLQAFLEDYFTATE 528
>P42683:LCK_CHICK Proto-oncogene tyrosine-protein kinase LCK - Gallus gallus (Chicken)| Length = 508 Score = 145 bits (365), Expect = 7e-34 Identities = 92/263 (34%), Positives = 144/263 (54%), Gaps = 5/263 (1%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGR-EVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVS 807 + +G+ V+ G YNG +VAIK + Q + F +E L+ L+H +V Sbjct: 249 KLGAGQFGEVWMGFYNGHTKVAIKNLKQGSMSPSA-------FLAEANLMKNLQHPRLVR 301 Query: 808 FVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGIL 987 A K P++ IITEYM GSL +L E + I +L +A IA GM+++ ++ + Sbjct: 302 LYAVVTKEPIY-IITEYMEKGSLVDFLKTSEGIKLSINKLLDMAAQIAEGMAFIEAKNYI 360 Query: 988 HRDLKSENVLLGEDMSVKVADFGISCL--ESQCGSGKGFTGTYRWMAPEMIKEKNHTRKV 1161 HRDL++ N+L+ E + K+ADFG++ L +++ + +G +W APE I T K Sbjct: 361 HRDLRAANILVSEALCCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKS 420 Query: 1162 DVYSFGIVLWEILT-ALVPFSEMT-PEQAAIAVALKNARPPLPASCPVAMSHLISQCWAT 1335 DV+SFGI+L EI+T +P+ MT PE I + R P P +CP + L+ QCW Sbjct: 421 DVWSFGILLTEIVTYGRIPYPGMTNPE--VIQNLERGYRMPQPDNCPQELYELMMQCWKE 478 Query: 1336 NPDKRPQFDDIVVVLEGYKEALD 1404 P++RP F+ + VLE + A + Sbjct: 479 QPEERPTFEYMKSVLEDFFTATE 501
>P05625:RAF1_CHICK RAF proto-oncogene serine/threonine-protein kinase - Gallus gallus| (Chicken) Length = 647 Score = 144 bits (364), Expect = 9e-34 Identities = 91/267 (34%), Positives = 151/267 (56%), Gaps = 10/267 (3%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGREVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSF 810 R SG VY G+++G +VA+K++ E + F +EVA+L + RH NI+ F Sbjct: 354 RIGSGSFGTVYKGKWHG-DVAVKILKVVDP----TPEQFQAFRNEVAVLRKTRHVNILLF 408 Query: 811 VAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGILH 990 + K + I+T++ G SL K+LH QE QL+ +A A+GM YLH++ I+H Sbjct: 409 MGYMTKDNL-AIVTQWCEGSSLYKHLHVQETKFQMFQLI-DIARQTAQGMDYLHAKNIIH 466 Query: 991 RDLKSENVLLGEDMSVKVADFGISCLESQCGSGKGF---TGTYRWMAPEMIKEKN---HT 1152 RD+KS N+ L E ++VK+ DFG++ ++S+ + TG+ WMAPE+I+ ++ + Sbjct: 467 RDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSILWMAPEVIRMQDSNPFS 526 Query: 1153 RKVDVYSFGIVLWEILTALVPFSEMTPEQAAIAVALKNARPP----LPASCPVAMSHLIS 1320 + DVYS+GIVL+E++T +P+S + I + + P L +CP AM L++ Sbjct: 527 FQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVA 586 Query: 1321 QCWATNPDKRPQFDDIVVVLEGYKEAL 1401 C ++RP F I+ +E + +L Sbjct: 587 DCLKKVREERPLFPQILSSIELLQHSL 613
>P13406:FYN_XENLA Proto-oncogene tyrosine-protein kinase Fyn - Xenopus laevis (African| clawed frog) Length = 537 Score = 144 bits (362), Expect = 2e-33 Identities = 84/262 (32%), Positives = 144/262 (54%), Gaps = 4/262 (1%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGR-EVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVS 807 R +G+ V+ G +NG +VAIK + + ++ E F E ++ +L+H +V Sbjct: 276 RLGNGQFGEVWMGTWNGNTKVAIKTL----KPGTMSPE---SFLEEAQIMKKLKHDKLVQ 328 Query: 808 FVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGIL 987 A + P++ I+TEYM+ GSL +L E ++ + ++ +A +ARGM+Y+ + Sbjct: 329 LYAVVSEEPIY-IVTEYMSKGSLLDFLKDGEGRALKLPNLVDMAAQVARGMAYIERMNYI 387 Query: 988 HRDLKSENVLLGEDMSVKVADFGISCL--ESQCGSGKGFTGTYRWMAPEMIKEKNHTRKV 1161 HRDL+S N+L+G + K+ADFG++ L +++ + +G +W APE T K Sbjct: 388 HRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKS 447 Query: 1162 DVYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATN 1338 DV+SFGI+L E++T VP+ M + V + R P P CP+++ L+ CW + Sbjct: 448 DVWSFGILLTELVTKGRVPYPGMNNREVLEQVE-RGYRMPCPQDCPISLHELMLNCWKKD 506 Query: 1339 PDKRPQFDDIVVVLEGYKEALD 1404 P++RP F+ + LE Y A + Sbjct: 507 PEERPTFEYLQGFLEDYFTATE 528
>Q62073:M3K7_MOUSE Mitogen-activated protein kinase kinase kinase 7 - Mus musculus| (Mouse) Length = 579 Score = 143 bits (361), Expect = 2e-33 Identities = 86/246 (34%), Positives = 135/246 (54%), Gaps = 9/246 (3%) Frame = +1 Query: 670 RYNGREVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSFVAACKKPPVFCII 849 ++ ++VAIK + E A EL + L R+ H NIV AC P C++ Sbjct: 54 KWRAKDVAIKQIESESERKAFIVELRQ--------LSRVNHPNIVKLYGACLNP--VCLV 103 Query: 850 TEYMAGGSLRKYLHQQEPHSVPIQLV---LQLALDIARGMSYLHS---QGILHRDLKSEN 1011 EY GGSL LH EP +P + L ++G++YLHS + ++HRDLK N Sbjct: 104 MEYAEGGSLYNVLHGAEP--LPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPN 161 Query: 1012 VLLGEDMSV-KVADFGISC-LESQCGSGKGFTGTYRWMAPEMIKEKNHTRKVDVYSFGIV 1185 +LL +V K+ DFG +C +++ + KG WMAPE+ + N++ K DV+S+GI+ Sbjct: 162 LLLVAGGTVLKICDFGTACDIQTHMTNNKGSAA---WMAPEVFEGSNYSEKCDVFSWGII 218 Query: 1186 LWEILTALVPFSEMTPEQAAIAVALKN-ARPPLPASCPVAMSHLISQCWATNPDKRPQFD 1362 LWE++T PF E+ I A+ N RPPL + P + L+++CW+ +P +RP + Sbjct: 219 LWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSME 278 Query: 1363 DIVVVL 1380 +IV ++ Sbjct: 279 EIVKIM 284
>O43318:M3K7_HUMAN Mitogen-activated protein kinase kinase kinase 7 - Homo sapiens| (Human) Length = 606 Score = 143 bits (361), Expect = 2e-33 Identities = 86/246 (34%), Positives = 135/246 (54%), Gaps = 9/246 (3%) Frame = +1 Query: 670 RYNGREVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSFVAACKKPPVFCII 849 ++ ++VAIK + E A EL + L R+ H NIV AC P C++ Sbjct: 54 KWRAKDVAIKQIESESERKAFIVELRQ--------LSRVNHPNIVKLYGACLNP--VCLV 103 Query: 850 TEYMAGGSLRKYLHQQEPHSVPIQLV---LQLALDIARGMSYLHS---QGILHRDLKSEN 1011 EY GGSL LH EP +P + L ++G++YLHS + ++HRDLK N Sbjct: 104 MEYAEGGSLYNVLHGAEP--LPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPN 161 Query: 1012 VLLGEDMSV-KVADFGISC-LESQCGSGKGFTGTYRWMAPEMIKEKNHTRKVDVYSFGIV 1185 +LL +V K+ DFG +C +++ + KG WMAPE+ + N++ K DV+S+GI+ Sbjct: 162 LLLVAGGTVLKICDFGTACDIQTHMTNNKGSAA---WMAPEVFEGSNYSEKCDVFSWGII 218 Query: 1186 LWEILTALVPFSEMTPEQAAIAVALKN-ARPPLPASCPVAMSHLISQCWATNPDKRPQFD 1362 LWE++T PF E+ I A+ N RPPL + P + L+++CW+ +P +RP + Sbjct: 219 LWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSME 278 Query: 1363 DIVVVL 1380 +IV ++ Sbjct: 279 EIVKIM 284
>P10398:ARAF_HUMAN A-Raf proto-oncogene serine/threonine-protein kinase - Homo sapiens| (Human) Length = 606 Score = 143 bits (360), Expect = 3e-33 Identities = 88/269 (32%), Positives = 155/269 (57%), Gaps = 12/269 (4%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGREVAIKM--VSQPHEDDALAAELERQFASEVALLLRLRHHNIV 804 R +G V+ GR++G +VA+K+ VSQP AE + F +E+ +L + RH NI+ Sbjct: 315 RIGTGSFGTVFRGRWHG-DVAVKVLKVSQP------TAEQAQAFKNEMQVLRKTRHVNIL 367 Query: 805 SFVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGI 984 F+ +P F IIT++ G SL +LH + +QL+ +A A+GM YLH++ I Sbjct: 368 LFMGFMTRPG-FAIITQWCEGSSLYHHLHVADTRFDMVQLI-DVARQTAQGMDYLHAKNI 425 Query: 985 LHRDLKSENVLLGEDMSVKVADFGISCLESQCGSGKGF---TGTYRWMAPEMIKEKN--- 1146 +HRDLKS N+ L E ++VK+ DFG++ ++++ + +G+ WMA E+I+ ++ Sbjct: 426 IHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNP 485 Query: 1147 HTRKVDVYSFGIVLWEILTALVPFSEMTPEQAAIAVALKNARPP----LPASCPVAMSHL 1314 ++ + DVY++G+VL+E++T +P+S + I + + P + ++CP AM L Sbjct: 486 YSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRL 545 Query: 1315 ISQCWATNPDKRPQFDDIVVVLEGYKEAL 1401 +S C ++RP F I+ +E + +L Sbjct: 546 LSDCLKFQREERPLFPQILATIELLQRSL 574
>O19004:ARAF_PIG A-Raf proto-oncogene serine/threonine-protein kinase - Sus scrofa| (Pig) Length = 606 Score = 142 bits (359), Expect = 4e-33 Identities = 87/269 (32%), Positives = 155/269 (57%), Gaps = 12/269 (4%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGREVAIKM--VSQPHEDDALAAELERQFASEVALLLRLRHHNIV 804 R +G V+ GR++G +VA+K+ V+QP AE + F +E+ +L + RH NI+ Sbjct: 315 RIGTGSFGTVFRGRWHG-DVAVKVLKVAQP------TAEQAQAFKNEMQVLRKTRHVNIL 367 Query: 805 SFVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGI 984 F+ +P F IIT++ G SL +LH + +QL+ +A A+GM YLH++ I Sbjct: 368 LFMGFMTRPG-FAIITQWCEGSSLYHHLHVADTRFDMVQLI-DVARQTAQGMDYLHAKNI 425 Query: 985 LHRDLKSENVLLGEDMSVKVADFGISCLESQCGSGKGF---TGTYRWMAPEMIKEKN--- 1146 +HRDLKS N+ L E ++VK+ DFG++ ++++ + +G+ WMA E+I+ ++ Sbjct: 426 IHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNP 485 Query: 1147 HTRKVDVYSFGIVLWEILTALVPFSEMTPEQAAIAVALKNARPP----LPASCPVAMSHL 1314 ++ + DVY++G+VL+E++T +P+S + I + + P + ++CP AM L Sbjct: 486 YSFQSDVYAYGVVLYELMTGSLPYSHIGSRDQIIFMVGRGYLSPDLSKISSNCPKAMRRL 545 Query: 1315 ISQCWATNPDKRPQFDDIVVVLEGYKEAL 1401 +S C ++RP F I+ +E + +L Sbjct: 546 LSDCLKFQREERPLFPQILATIELLQRSL 574
>Q99N57:RAF1_MOUSE RAF proto-oncogene serine/threonine-protein kinase - Mus musculus| (Mouse) Length = 648 Score = 142 bits (357), Expect = 6e-33 Identities = 90/267 (33%), Positives = 151/267 (56%), Gaps = 10/267 (3%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGREVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSF 810 R SG VY G+++G +VA+K++ D +L+ F +EVA+L + RH NI+ F Sbjct: 354 RIGSGSFGTVYKGKWHG-DVAVKILKVV---DPTPEQLQA-FRNEVAVLRKTRHVNILLF 408 Query: 811 VAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGILH 990 + K + I+T++ G SL K+LH QE QL+ +A A+GM YLH++ I+H Sbjct: 409 MGYMTKDNL-AIVTQWCEGSSLYKHLHVQETKFQMFQLI-DIARQTAQGMDYLHAKNIIH 466 Query: 991 RDLKSENVLLGEDMSVKVADFGISCLESQCGSGKGF---TGTYRWMAPEMIK---EKNHT 1152 RD+KS N+ L E ++VK+ DFG++ ++S+ + TG+ WMAPE+I+ + + Sbjct: 467 RDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDDNPFS 526 Query: 1153 RKVDVYSFGIVLWEILTALVPFSEMTPEQAAIAVALKNARPP----LPASCPVAMSHLIS 1320 + DVYS+GIVL+E++ +P++ + I + + P L +CP AM L++ Sbjct: 527 FQSDVYSYGIVLYELMAGELPYAHINNRDQIIFMVGRGYASPDLSRLYKNCPKAMKRLVA 586 Query: 1321 QCWATNPDKRPQFDDIVVVLEGYKEAL 1401 C ++RP F I+ +E + +L Sbjct: 587 DCVKKVKEERPLFPQILSSIELLQHSL 613
>Q95KR7:LCK_SAISC Proto-oncogene tyrosine-protein kinase LCK - Saimiri sciureus (Common| squirrel monkey) Length = 509 Score = 142 bits (357), Expect = 6e-33 Identities = 92/264 (34%), Positives = 142/264 (53%), Gaps = 6/264 (2%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGR-EVAIKMVSQPH-EDDALAAELERQFASEVALLLRLRHHNIV 804 R +G+ V+ G YN +VA+K + Q DA F +E L+ +L+H +V Sbjct: 250 RLGAGQFGEVWMGYYNEHTKVAVKSLKQGSMSPDA--------FLAEANLMKQLQHKRLV 301 Query: 805 SFVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGI 984 A + P++ IITEYM GSL +L + I +L +A I GM++L + Sbjct: 302 RLYAVVTEEPIY-IITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIVEGMAFLEERNY 360 Query: 985 LHRDLKSENVLLGEDMSVKVADFGISCL--ESQCGSGKGFTGTYRWMAPEMIKEKNHTRK 1158 +HRDL++ N+L+ + +S K+ADFG++ L +++ + +G +W APE I T K Sbjct: 361 IHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIK 420 Query: 1159 VDVYSFGIVLWEILT-ALVPFSEMT-PEQAAIAVALKNARPPLPASCPVAMSHLISQCWA 1332 DV+SFGI++ EI+T +P+ MT PE I + R P P +CP + L+ QCW Sbjct: 421 SDVWSFGILMTEIVTHGRIPYPGMTNPE--VIQNLERGYRMPRPDNCPEELYKLMMQCWR 478 Query: 1333 TNPDKRPQFDDIVVVLEGYKEALD 1404 PD RP FD + VLE + A + Sbjct: 479 ERPDDRPTFDYLRSVLEDFFTATE 502
>P06240:LCK_MOUSE Proto-oncogene tyrosine-protein kinase LCK - Mus musculus (Mouse)| Length = 509 Score = 141 bits (356), Expect = 8e-33 Identities = 91/264 (34%), Positives = 143/264 (54%), Gaps = 6/264 (2%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGR-EVAIKMVSQPH-EDDALAAELERQFASEVALLLRLRHHNIV 804 R +G+ V+ G YNG +VA+K + Q DA F +E L+ +L+H +V Sbjct: 250 RLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDA--------FLAEANLMKQLQHPRLV 301 Query: 805 SFVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGI 984 A + P++ IITEYM GSL +L + + +L +A IA GM+++ Q Sbjct: 302 RLYAVVTQEPIY-IITEYMENGSLVDFLKTPSGIKLNVNKLLDMAAQIAEGMAFIEEQNY 360 Query: 985 LHRDLKSENVLLGEDMSVKVADFGISCL--ESQCGSGKGFTGTYRWMAPEMIKEKNHTRK 1158 +HRDL++ N+L+ + +S K+ADFG++ L +++ + +G +W APE I T K Sbjct: 361 IHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIK 420 Query: 1159 VDVYSFGIVLWEILT-ALVPFSEMT-PEQAAIAVALKNARPPLPASCPVAMSHLISQCWA 1332 DV+SFGI+L EI+T +P+ MT PE I + R P +CP + HL+ CW Sbjct: 421 SDVWSFGILLTEIVTHGRIPYPGMTNPE--VIQNLERGYRMVRPDNCPEELYHLMMLCWK 478 Query: 1333 TNPDKRPQFDDIVVVLEGYKEALD 1404 P+ RP FD + VL+ + A + Sbjct: 479 ERPEDRPTFDYLRSVLDDFFTATE 502
>P39688:FYN_MOUSE Proto-oncogene tyrosine-protein kinase Fyn - Mus musculus (Mouse)| Length = 537 Score = 141 bits (356), Expect = 8e-33 Identities = 83/262 (31%), Positives = 143/262 (54%), Gaps = 4/262 (1%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGR-EVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVS 807 R +G+ V+ G +NG +VAIK + + ++ E F E ++ +L+H +V Sbjct: 276 RLGNGQFGEVWLGTWNGNTKVAIKTL----KPGTMSPE---SFLEEAQIMKKLKHDKLVQ 328 Query: 808 FVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGIL 987 A + P++ I+TEYM+ GSL +L E ++ + ++ +A +A GM+Y+ + Sbjct: 329 LYAVVSEEPIY-IVTEYMSKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYI 387 Query: 988 HRDLKSENVLLGEDMSVKVADFGISCL--ESQCGSGKGFTGTYRWMAPEMIKEKNHTRKV 1161 HRDL+S N+L+G + K+ADFG++ L +++ + +G +W APE T K Sbjct: 388 HRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKS 447 Query: 1162 DVYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATN 1338 DV+SFGI+L E++T VP+ M + V + R P P CP+++ L+ CW + Sbjct: 448 DVWSFGILLTELVTKGRVPYPGMNNREVLEQVE-RGYRMPCPQDCPISLHELMIHCWKKD 506 Query: 1339 PDKRPQFDDIVVVLEGYKEALD 1404 P++RP F+ + LE Y A + Sbjct: 507 PEERPTFEYLQGFLEDYFTATE 528
>P42685:FRK_HUMAN Tyrosine-protein kinase FRK - Homo sapiens (Human)| Length = 505 Score = 141 bits (355), Expect = 1e-32 Identities = 89/262 (33%), Positives = 133/262 (50%), Gaps = 7/262 (2%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGRE-VAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVS 807 R SG+ V+ G +N VA+K + D F E ++ LRH ++ Sbjct: 239 RLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDP-------NDFLREAQIMKNLRHPKLIQ 291 Query: 808 FVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGIL 987 A C IITE M GSL++YL + + + +A +A GM+YL S+ + Sbjct: 292 LYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAYLESRNYI 351 Query: 988 HRDLKSENVLLGEDMSVKVADFGISCL-----ESQCGSGKGFTGTYRWMAPEMIKEKNHT 1152 HRDL + NVL+GE KVADFG++ + E S +W APE I+ + Sbjct: 352 HRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTAPEAIRSNKFS 411 Query: 1153 RKVDVYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCW 1329 K DV+SFGI+L+EI+T +P+S MT Q I + +N R P P++CP +++ +CW Sbjct: 412 IKSDVWSFGILLYEIITYGKMPYSGMTGAQ-VIQMLAQNYRLPQPSNCPQQFYNIMLECW 470 Query: 1330 ATNPDKRPQFDDIVVVLEGYKE 1395 P +RP F+ + LE Y E Sbjct: 471 NAEPKERPTFETLRWKLEDYFE 492
>P06241:FYN_HUMAN Proto-oncogene tyrosine-protein kinase Fyn - Homo sapiens (Human)| Length = 537 Score = 140 bits (354), Expect = 1e-32 Identities = 83/262 (31%), Positives = 142/262 (54%), Gaps = 4/262 (1%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGR-EVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVS 807 R +G+ V+ G +NG +VAIK + + ++ E F E ++ +L+H +V Sbjct: 276 RLGNGQFGEVWMGTWNGNTKVAIKTL----KPGTMSPE---SFLEEAQIMKKLKHDKLVQ 328 Query: 808 FVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGIL 987 A + P++ I+TEYM GSL +L E ++ + ++ +A +A GM+Y+ + Sbjct: 329 LYAVVSEEPIY-IVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYI 387 Query: 988 HRDLKSENVLLGEDMSVKVADFGISCL--ESQCGSGKGFTGTYRWMAPEMIKEKNHTRKV 1161 HRDL+S N+L+G + K+ADFG++ L +++ + +G +W APE T K Sbjct: 388 HRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKS 447 Query: 1162 DVYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATN 1338 DV+SFGI+L E++T VP+ M + V + R P P CP+++ L+ CW + Sbjct: 448 DVWSFGILLTELVTKGRVPYPGMNNREVLEQVE-RGYRMPCPQDCPISLHELMIHCWKKD 506 Query: 1339 PDKRPQFDDIVVVLEGYKEALD 1404 P++RP F+ + LE Y A + Sbjct: 507 PEERPTFEYLQSFLEDYFTATE 528
>P14056:ARAF_RAT A-Raf proto-oncogene serine/threonine-protein kinase - Rattus| norvegicus (Rat) Length = 604 Score = 140 bits (354), Expect = 1e-32 Identities = 88/269 (32%), Positives = 156/269 (57%), Gaps = 12/269 (4%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGREVAIKM--VSQPHEDDALAAELERQFASEVALLLRLRHHNIV 804 R +G V+ GR++G +VA+K+ V+QP AE + F +E+ +L + RH NI+ Sbjct: 313 RIGTGSFGTVFRGRWHG-DVAVKVLKVAQP------TAEQAQAFKNEMQVLRKTRHVNIL 365 Query: 805 SFVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGI 984 F+ +P F IIT++ G SL +LH + +QL+ +A A+GM YLH++ I Sbjct: 366 LFMGFMTRPG-FAIITQWCEGSSLYHHLHVADTRFDMVQLI-DVARQTAQGMDYLHAKNI 423 Query: 985 LHRDLKSENVLLGEDMSVKVADFGISCLESQCGSGKGF---TGTYRWMAPEMIKEKN--- 1146 +HRDLKS N+ L E ++VK+ DFG++ ++++ + +G+ WMA E+I+ ++ Sbjct: 424 IHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNP 483 Query: 1147 HTRKVDVYSFGIVLWEILTALVPFSEM-TPEQAAIAVALKNARPPLP---ASCPVAMSHL 1314 ++ + DVY++G+VL+E++T +P+S + + +Q V P L ++CP AM L Sbjct: 484 YSFQSDVYAYGVVLYELMTGSLPYSHIGSRDQIIFMVGRGYLSPDLSKIFSNCPKAMRRL 543 Query: 1315 ISQCWATNPDKRPQFDDIVVVLEGYKEAL 1401 ++ C ++RP F I+ +E + +L Sbjct: 544 LTDCLKFQREERPLFPQILATIELLQRSL 572
>P04627:ARAF_MOUSE A-Raf proto-oncogene serine/threonine-protein kinase - Mus musculus| (Mouse) Length = 604 Score = 140 bits (354), Expect = 1e-32 Identities = 88/269 (32%), Positives = 156/269 (57%), Gaps = 12/269 (4%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGREVAIKM--VSQPHEDDALAAELERQFASEVALLLRLRHHNIV 804 R +G V+ GR++G +VA+K+ V+QP AE + F +E+ +L + RH NI+ Sbjct: 313 RIGTGSFGTVFRGRWHG-DVAVKVLKVAQP------TAEQAQAFKNEMQVLRKTRHVNIL 365 Query: 805 SFVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGI 984 F+ +P F IIT++ G SL +LH + +QL+ +A A+GM YLH++ I Sbjct: 366 LFMGFMTRPG-FAIITQWCEGSSLYHHLHVADTRFDMVQLI-DVARQTAQGMDYLHAKNI 423 Query: 985 LHRDLKSENVLLGEDMSVKVADFGISCLESQCGSGKGF---TGTYRWMAPEMIKEKN--- 1146 +HRDLKS N+ L E ++VK+ DFG++ ++++ + +G+ WMA E+I+ ++ Sbjct: 424 IHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNP 483 Query: 1147 HTRKVDVYSFGIVLWEILTALVPFSEM-TPEQAAIAVALKNARPPLP---ASCPVAMSHL 1314 ++ + DVY++G+VL+E++T +P+S + + +Q V P L ++CP AM L Sbjct: 484 YSFQSDVYAYGVVLYELMTGSLPYSHIGSRDQIIFMVGRGYLSPDLSKIFSNCPKAMRRL 543 Query: 1315 ISQCWATNPDKRPQFDDIVVVLEGYKEAL 1401 ++ C ++RP F I+ +E + +L Sbjct: 544 LTDCLKFQREERPLFPQILATIELLQRSL 572
>P00527:YES_AVISY Tyrosine-protein kinase transforming protein YES - Avian sarcoma| virus (strain Y73) Length = 528 Score = 140 bits (353), Expect = 2e-32 Identities = 84/262 (32%), Positives = 139/262 (53%), Gaps = 4/262 (1%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGR-EVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVS 807 + G V+ G +NG +VAIK + L + F E ++ +LRH +V Sbjct: 272 KLGQGCFGEVWMGTWNGTTKVAIKTLK-------LGTMMPEAFLQEAQIMKKLRHDKLVP 324 Query: 808 FVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGIL 987 A + P++ I+TE+M GSL +L + E + + ++ +A IA GM+Y+ + Sbjct: 325 LYAVVSEEPIY-IVTEFMTKGSLLDFLKEGEGKFLKLPQLVDMAAQIADGMAYIERMNYI 383 Query: 988 HRDLKSENVLLGEDMSVKVADFGISCL--ESQCGSGKGFTGTYRWMAPEMIKEKNHTRKV 1161 HRDL++ N+L+G+++ K+ADFG++ L +++ + +G +W APE T K Sbjct: 384 HRDLRAANILVGDNLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKS 443 Query: 1162 DVYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATN 1338 DV+SFGI+L E++T VP+ M + V + R P P CP ++ L+ CW + Sbjct: 444 DVWSFGILLTELVTKGRVPYPGMVNREVLEQVE-RGYRMPCPQGCPESLHELMKLCWKKD 502 Query: 1339 PDKRPQFDDIVVVLEGYKEALD 1404 PD+RP F+ I LE Y A + Sbjct: 503 PDERPTFEYIQSFLEDYFTAAE 524
>P00532:RAF_MSV36 Serine/threonine-protein kinase-transforming protein raf - Murine| sarcoma virus 3611 Length = 323 Score = 140 bits (353), Expect = 2e-32 Identities = 89/267 (33%), Positives = 151/267 (56%), Gaps = 10/267 (3%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGREVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSF 810 R SG VY G+++G +VA+K++ D +L+ F +EVA+L + RH NI+ F Sbjct: 29 RIGSGSFGTVYKGKWHG-DVAVKILKVV---DPTPEQLQA-FRNEVAVLRKTRHVNILLF 83 Query: 811 VAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGILH 990 + K + I+T++ G SL K+LH QE QL+ +A A+GM YLH++ I+H Sbjct: 84 MGYMTKDNL-AIVTQWCEGSSLYKHLHVQETKFQMFQLI-DIARQTAQGMDYLHAKNIIH 141 Query: 991 RDLKSENVLLGEDMSVKVADFGISCLESQCGSGKGF---TGTYRWMAPEMIK---EKNHT 1152 RD+KS N+ L E ++VK+ DFG++ ++S+ + TG+ WMAPE+I+ + + Sbjct: 142 RDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDDNPFS 201 Query: 1153 RKVDVYSFGIVLWEILTALVPFSEMTPEQAAIAVALKNARPP----LPASCPVAMSHLIS 1320 + DVYS+GIVL+E++ +P++ + I + + P L +CP A+ L++ Sbjct: 202 FQSDVYSYGIVLYELMAGELPYAHINNRDQIIFMVGRGYASPDLSRLYKNCPKAIKRLVA 261 Query: 1321 QCWATNPDKRPQFDDIVVVLEGYKEAL 1401 C ++RP F I+ +E + +L Sbjct: 262 DCVKKVKEERPLFPQILSSIELLQHSL 288
>P00531:MIL_AVIMH Serine/threonine-protein kinase-transforming protein mil - Avian| retrovirus MH2 Length = 380 Score = 140 bits (353), Expect = 2e-32 Identities = 88/257 (34%), Positives = 145/257 (56%), Gaps = 10/257 (3%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGREVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSF 810 R SG VY G+++G +VA+K++ E + F +EVA+L + RH NI+ F Sbjct: 87 RIGSGSFGTVYKGKWHG-DVAVKILKVVDP----TPEQFQAFRNEVAVLRKTRHVNILLF 141 Query: 811 VAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGILH 990 + K + I+T++ G SL K+LH QE QL+ +A A+GM YLH++ I+H Sbjct: 142 MGYMTKDNL-AIVTQWCEGSSLYKHLHVQETKFQMFQLI-DIARQTAQGMDYLHAKNIIH 199 Query: 991 RDLKSENVLLGEDMSVKVADFGISCLESQCGSGKGF---TGTYRWMAPEMIKEKN---HT 1152 RD+KS N+ L ++VK+ DFG++ ++S+ + TG+ WMAPE+I+ ++ + Sbjct: 200 RDMKSNNIFLHGGLTVKIGDFGLATVKSRWSGSQQVEQPTGSILWMAPEVIRMQDSNPFS 259 Query: 1153 RKVDVYSFGIVLWEILTALVPFSEMTPEQAAIAVALKNARPP----LPASCPVAMSHLIS 1320 + DVYS+GIVL+E++T +P+S + I + + P L +CP AM L++ Sbjct: 260 FQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVA 319 Query: 1321 QCWATNPDKRPQFDDIV 1371 C ++RP F I+ Sbjct: 320 DCLKKVREERPLFPQIL 336
>Q62844:FYN_RAT Proto-oncogene tyrosine-protein kinase Fyn - Rattus norvegicus (Rat)| Length = 537 Score = 140 bits (353), Expect = 2e-32 Identities = 83/262 (31%), Positives = 142/262 (54%), Gaps = 4/262 (1%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGR-EVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVS 807 R +G+ V+ G +NG +VAIK + + ++ E F E ++ +L+H +V Sbjct: 276 RLGNGQFGEVWMGTWNGNTKVAIKTL----KPGTMSPE---SFLEEAQIMKKLKHDKLVQ 328 Query: 808 FVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGIL 987 A + P++ I+TEYM GSL +L E ++ + ++ +A +A GM+Y+ + Sbjct: 329 LYAVVSEEPIY-IVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYI 387 Query: 988 HRDLKSENVLLGEDMSVKVADFGISCL--ESQCGSGKGFTGTYRWMAPEMIKEKNHTRKV 1161 HRDL+S N+L+G + K+ADFG++ L +++ + +G +W APE T K Sbjct: 388 HRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKS 447 Query: 1162 DVYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATN 1338 DV+SFGI+L E++T VP+ M + V + R P P CP+++ L+ CW + Sbjct: 448 DVWSFGILLTELVTKGRVPYPGMNNREVLEQVE-RGYRMPCPQDCPISLHELMIHCWKKD 506 Query: 1339 PDKRPQFDDIVVVLEGYKEALD 1404 P++RP F+ + LE Y A + Sbjct: 507 PEERPTFEYLQGFLEDYFTATE 528
>A1Y2K1:FYN_PIG Proto-oncogene tyrosine-protein kinase Fyn - Sus scrofa (Pig)| Length = 537 Score = 140 bits (353), Expect = 2e-32 Identities = 83/262 (31%), Positives = 142/262 (54%), Gaps = 4/262 (1%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGR-EVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVS 807 R +G+ V+ G +NG +VAIK + + ++ E F E ++ +L+H +V Sbjct: 276 RLGNGQFGEVWMGTWNGNTKVAIKTL----KPGTMSPE---SFLEEAQIMKKLKHDKLVQ 328 Query: 808 FVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGIL 987 A + P++ I+TEYM GSL +L E ++ + ++ +A +A GM+Y+ + Sbjct: 329 LYAVVSEEPIY-IVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYI 387 Query: 988 HRDLKSENVLLGEDMSVKVADFGISCL--ESQCGSGKGFTGTYRWMAPEMIKEKNHTRKV 1161 HRDL+S N+L+G + K+ADFG++ L +++ + +G +W APE T K Sbjct: 388 HRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKS 447 Query: 1162 DVYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATN 1338 DV+SFGI+L E++T VP+ M + V + R P P CP+++ L+ CW + Sbjct: 448 DVWSFGILLTELVTKGRVPYPGMNNREVLEQVE-RGYRMPCPQDCPISLHELMIHCWKKD 506 Query: 1339 PDKRPQFDDIVVVLEGYKEALD 1404 P++RP F+ + LE Y A + Sbjct: 507 PEERPTFEYLQGFLEDYFTATE 528
>A0JNB0:FYN_BOVIN Proto-oncogene tyrosine-protein kinase Fyn - Bos taurus (Bovine)| Length = 537 Score = 140 bits (353), Expect = 2e-32 Identities = 83/262 (31%), Positives = 142/262 (54%), Gaps = 4/262 (1%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGR-EVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVS 807 R +G+ V+ G +NG +VAIK + + ++ E F E ++ +L+H +V Sbjct: 276 RLGNGQFGEVWMGTWNGNTKVAIKTL----KPGTMSPE---SFLEEAQIMKKLKHDKLVQ 328 Query: 808 FVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGIL 987 A + P++ I+TEYM GSL +L E ++ + ++ +A +A GM+Y+ + Sbjct: 329 LYAVVSEEPIY-IVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYI 387 Query: 988 HRDLKSENVLLGEDMSVKVADFGISCL--ESQCGSGKGFTGTYRWMAPEMIKEKNHTRKV 1161 HRDL+S N+L+G + K+ADFG++ L +++ + +G +W APE T K Sbjct: 388 HRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKS 447 Query: 1162 DVYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATN 1338 DV+SFGI+L E++T VP+ M + V + R P P CP+++ L+ CW + Sbjct: 448 DVWSFGILLTELVTKGRVPYPGMNNREVLEQVE-RGYRMPCPQDCPISLHELMIHCWKKD 506 Query: 1339 PDKRPQFDDIVVVLEGYKEALD 1404 P++RP F+ + LE Y A + Sbjct: 507 PEERPTFEYLQGFLEDYFTATE 528
>Q5PXS1:LCK_AOTNA Proto-oncogene tyrosine-protein kinase LCK - Aotus nancymaae (Ma's| night monkey) Length = 509 Score = 140 bits (352), Expect = 2e-32 Identities = 91/264 (34%), Positives = 142/264 (53%), Gaps = 6/264 (2%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGR-EVAIKMVSQPH-EDDALAAELERQFASEVALLLRLRHHNIV 804 R +G+ V+ G YN +VA+K + Q DA F +E L+ +L+H +V Sbjct: 250 RLGAGQFGEVWMGYYNDHTKVAVKSLKQGSMSPDA--------FLAEANLMKQLQHQRLV 301 Query: 805 SFVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGI 984 A + P++ IITEYM GSL +L + I +L +A IA GM+++ + Sbjct: 302 RLYAVVTQEPIY-IITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNY 360 Query: 985 LHRDLKSENVLLGEDMSVKVADFGISCL--ESQCGSGKGFTGTYRWMAPEMIKEKNHTRK 1158 +HRDL++ N+L+ + +S K+ADFG++ L +++ + +G +W APE I T K Sbjct: 361 IHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIK 420 Query: 1159 VDVYSFGIVLWEILT-ALVPFSEMT-PEQAAIAVALKNARPPLPASCPVAMSHLISQCWA 1332 DV+SFGI+L EI+T +P+ MT PE I + R P +CP + HL+ CW Sbjct: 421 SDVWSFGILLTEIVTHGRIPYPGMTNPE--VIQNLERGYRMVRPDNCPEELYHLMMLCWK 478 Query: 1333 TNPDKRPQFDDIVVVLEGYKEALD 1404 P+ RP FD + VLE + A + Sbjct: 479 ERPEDRPTFDYLRSVLEDFFTATE 502
>Q07407:FGFR1_DROME Fibroblast growth factor receptor homolog 1 precursor - Drosophila| melanogaster (Fruit fly) Length = 729 Score = 140 bits (352), Expect = 2e-32 Identities = 87/269 (32%), Positives = 138/269 (51%), Gaps = 22/269 (8%) Frame = +1 Query: 643 GRHSRVYFGRYNGREVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSFVAAC 822 G RV N VA+KMV + H DD +A+ + EV ++ RH NI++ + C Sbjct: 425 GAFGRVVMAEVNNAIVAVKMVKEGHTDDDIASLVREM---EVMKIIG-RHINIINLLGCC 480 Query: 823 KKPPVFCIITEYMAGGSLRKYLHQQEP------------------HSVPIQLVLQLALDI 948 + +I EY G+L+ +L++ P H + + +++ A I Sbjct: 481 SQNGPLYVIVEYAPHGNLKDFLYKNRPFGRDQDRDSSQPPPSPPAHVITEKDLIKFAHQI 540 Query: 949 ARGMSYLHSQGILHRDLKSENVLLGEDMSVKVADFGIS-CLESQCGSGKGFTG--TYRWM 1119 ARGM YL S+ +HRDL + NVL+ +D +K+ADFG++ ++S K G +WM Sbjct: 541 ARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRLPIKWM 600 Query: 1120 APEMIKEKNHTRKVDVYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCP 1296 APE ++EK + K DV+S+GI+LWEI+T P+ + + + R PA C Sbjct: 601 APESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCS 660 Query: 1297 VAMSHLISQCWATNPDKRPQFDDIVVVLE 1383 + + L+ QCW N D RP F +IV ++ Sbjct: 661 MNIYILMRQCWHFNADDRPPFTEIVEYMD 689
>P06239:LCK_HUMAN Proto-oncogene tyrosine-protein kinase LCK - Homo sapiens (Human)| Length = 509 Score = 139 bits (351), Expect = 3e-32 Identities = 91/264 (34%), Positives = 142/264 (53%), Gaps = 6/264 (2%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGR-EVAIKMVSQPH-EDDALAAELERQFASEVALLLRLRHHNIV 804 R +G+ V+ G YNG +VA+K + Q DA F +E L+ +L+H +V Sbjct: 250 RLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDA--------FLAEANLMKQLQHQRLV 301 Query: 805 SFVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGI 984 A + P++ IITEYM GSL +L + I +L +A IA GM+++ + Sbjct: 302 RLYAVVTQEPIY-IITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNY 360 Query: 985 LHRDLKSENVLLGEDMSVKVADFGISCL--ESQCGSGKGFTGTYRWMAPEMIKEKNHTRK 1158 +HRDL++ N+L+ + +S K+ADFG++ L +++ + +G +W APE I T K Sbjct: 361 IHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIK 420 Query: 1159 VDVYSFGIVLWEILT-ALVPFSEMT-PEQAAIAVALKNARPPLPASCPVAMSHLISQCWA 1332 DV+SFGI+L EI+T +P+ MT PE I + R P +CP + L+ CW Sbjct: 421 SDVWSFGILLTEIVTHGRIPYPGMTNPE--VIQNLERGYRMVRPDNCPEELYQLMRLCWK 478 Query: 1333 TNPDKRPQFDDIVVVLEGYKEALD 1404 P+ RP FD + VLE + A + Sbjct: 479 ERPEDRPTFDYLRSVLEDFFTATE 502
>Q62662:FRK_RAT Tyrosine-protein kinase FRK - Rattus norvegicus (Rat)| Length = 506 Score = 139 bits (351), Expect = 3e-32 Identities = 90/262 (34%), Positives = 132/262 (50%), Gaps = 7/262 (2%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGRE-VAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVS 807 R SG+ V+ G +N VA+K + D F E ++ LRH ++ Sbjct: 240 RLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDP-------NDFLREAQIMKSLRHPKLIQ 292 Query: 808 FVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGIL 987 A C IITE M GSL++YL + + + +A +A GM+YL SQ + Sbjct: 293 LYAVCTLEDPIYIITELMRHGSLQEYLQNDGGSKIRLTQQVDMAAQVASGMAYLESQNYI 352 Query: 988 HRDLKSENVLLGEDMSVKVADFGISCL-----ESQCGSGKGFTGTYRWMAPEMIKEKNHT 1152 HRDL + NVL+GE KVADFG++ + E S +W APE I+ + Sbjct: 353 HRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESKHEIKLPVKWTAPEAIRTNKFS 412 Query: 1153 RKVDVYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCW 1329 K DV+SFGI+L+EI+T +P+S MT Q I + +N R P P++CP ++ +CW Sbjct: 413 IKSDVWSFGILLYEIITYGKMPYSGMTGAQ-VIHMLGQNYRLPQPSNCPEQFYSIMMECW 471 Query: 1330 ATNPDKRPQFDDIVVVLEGYKE 1395 P +RP F+ + LE Y E Sbjct: 472 NVEPKQRPTFETLHWKLEDYFE 493
>Q922K9:FRK_MOUSE Tyrosine-protein kinase FRK - Mus musculus (Mouse)| Length = 512 Score = 139 bits (351), Expect = 3e-32 Identities = 90/262 (34%), Positives = 132/262 (50%), Gaps = 7/262 (2%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGRE-VAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVS 807 R SG+ V+ G +N VA+K + D F E ++ LRH ++ Sbjct: 246 RLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDP-------NDFLREAQIMKSLRHPKLIQ 298 Query: 808 FVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGIL 987 A C IITE M GSL++YL + + + +A +A GM+YL SQ + Sbjct: 299 LYAVCTLEDPIYIITELMRHGSLQEYLQNDGGSKIHLIQQVDMAAQVASGMAYLESQNYI 358 Query: 988 HRDLKSENVLLGEDMSVKVADFGISCL-----ESQCGSGKGFTGTYRWMAPEMIKEKNHT 1152 HRDL + NVL+GE KVADFG++ + E S +W APE I+ + Sbjct: 359 HRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESKHEIKLPVKWTAPEAIRTNKFS 418 Query: 1153 RKVDVYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCW 1329 K DV+SFGI+L+EI+T +P+S MT Q I + +N R P P++CP ++ +CW Sbjct: 419 IKSDVWSFGILLYEIITYGKMPYSGMTGAQ-VIQMLSQNYRLPQPSNCPQQFYSIMLECW 477 Query: 1330 ATNPDKRPQFDDIVVVLEGYKE 1395 P +RP F+ + LE Y E Sbjct: 478 NVEPKQRPTFETLHWKLEDYFE 499
>P42686:SRK1_SPOLA Tyrosine-protein kinase isoform SRK1 - Spongilla lacustris| (Freshwater sponge) Length = 505 Score = 139 bits (349), Expect = 5e-32 Identities = 88/257 (34%), Positives = 136/257 (52%), Gaps = 4/257 (1%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGR-EVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVS 807 R +G+ V+ G +NG VA+K + + ++ E +F E +++ RLRH ++ Sbjct: 245 RLGAGQFGEVWEGLWNGTTSVAVKTL----KPGTMSVE---EFLQEASIMKRLRHPKLIQ 297 Query: 808 FVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGIL 987 A C K I+TE M GSL +YL + E + I+ ++ +A +A GMSYL Q + Sbjct: 298 LYAVCTKEEPIYIVTELMKYGSLLEYL-RGEDGVLKIEQLVDVAAQVASGMSYLEQQNYI 356 Query: 988 HRDLKSENVLLGEDMSVKVADFGISCL--ESQCGSGKGFTGTYRWMAPEMIKEKNHTRKV 1161 HRDL + N+L+GE KVADFG++ + E + G +W APE T K Sbjct: 357 HRDLAARNILVGEHGICKVADFGLARVIDEEIYEAHTGAKFPIKWTAPEAAMYNRFTIKS 416 Query: 1162 DVYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATN 1338 DV+SFG+VL+EI+T P+ MT + + +N R P PA+CP ++ CW + Sbjct: 417 DVWSFGVVLYEIITYGRFPYPGMTNPEVLEKIQ-QNYRMPCPANCPKQFHDIMLDCWRED 475 Query: 1339 PDKRPQFDDIVVVLEGY 1389 P RP F+ + LE + Sbjct: 476 PASRPTFETLQWQLEEF 492
>P42687:SPK1_DUGTI Tyrosine-protein kinase SPK-1 - Dugesia tigrina (Planarian)| Length = 497 Score = 139 bits (349), Expect = 5e-32 Identities = 92/256 (35%), Positives = 136/256 (53%), Gaps = 12/256 (4%) Frame = +1 Query: 628 GRFASGRHSRVYFGRYNGREVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVS 807 GR G R +GR EVA KM+ AE E+ F E ++ +LRH IV Sbjct: 227 GRGFFGSVHRAKWGR--SYEVAAKMLQSSK------AEREK-FVLEAKIMHKLRHRKIVE 277 Query: 808 FVAACKKPP--VFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQG 981 + C +P II EYM GSL++YL + + ++ + +I+ GM+YL S+ Sbjct: 278 LLGVCTEPQDMPMLIIVEYMKNGSLKEYLKTPDGKKTNLNQMVHMMAEISEGMAYLESEK 337 Query: 982 ILHRDLKSENVLLGEDMSVKVADFGISCL-ESQCG--SGKGFTGTYRWMAPEMIKEKNHT 1152 ++HRDL+++N+L+ D++ KVADFG++ L + G K Y+W APE K K T Sbjct: 338 VVHRDLRADNILVANDLTRKVADFGLTELTDGSLGDQEKKTLRFPYKWTAPEAAKSKVFT 397 Query: 1153 RKVDVYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPPLP------ASCPVAMSH 1311 K DV+S+GIV++EILT A P+ ++ P + I K R P P CP + Sbjct: 398 SKSDVWSYGIVMFEILTWASSPYPDI-PAKEVIEKVSKGYRMPNPEKFITGVCCPDEIYK 456 Query: 1312 LISQCWATNPDKRPQF 1359 ++ CW NP+KRP F Sbjct: 457 IMIWCWDANPEKRPTF 472
>P09324:YES_CHICK Tyrosine-protein kinase Yes - Gallus gallus (Chicken)| Length = 541 Score = 138 bits (348), Expect = 7e-32 Identities = 83/262 (31%), Positives = 138/262 (52%), Gaps = 4/262 (1%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGR-EVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVS 807 + G V+ G +NG +VAIK + + F E ++ +LRH +V Sbjct: 280 KLGQGCFGEVWMGTWNGTTKVAIKTLKP-------GTMMPEAFLQEAQIMKKLRHDKLVP 332 Query: 808 FVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGIL 987 A + P++ I+TE+M GSL +L + E + + ++ +A IA GM+Y+ + Sbjct: 333 LYAVVSEEPIY-IVTEFMTKGSLLDFLKEGEGKFLKLPQLVDMAAQIADGMAYIERMNYI 391 Query: 988 HRDLKSENVLLGEDMSVKVADFGISCL--ESQCGSGKGFTGTYRWMAPEMIKEKNHTRKV 1161 HRDL++ N+L+G+++ K+ADFG++ L +++ + +G +W APE T K Sbjct: 392 HRDLRAANILVGDNLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKS 451 Query: 1162 DVYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATN 1338 DV+SFGI+L E++T VP+ M + V + R P P CP ++ L+ CW + Sbjct: 452 DVWSFGILLTELVTKGRVPYPGMVNREVLEQVE-RGYRMPCPQGCPESLHELMKLCWKKD 510 Query: 1339 PDKRPQFDDIVVVLEGYKEALD 1404 PD+RP F+ I LE Y A + Sbjct: 511 PDERPTFEYIQSFLEDYFTATE 532
>Q28923:YES_CANFA Proto-oncogene tyrosine-protein kinase Yes - Canis familiaris (Dog)| Length = 539 Score = 138 bits (347), Expect = 9e-32 Identities = 83/262 (31%), Positives = 139/262 (53%), Gaps = 4/262 (1%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGR-EVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVS 807 + G V+ G +NG +VAIK + L + F E ++ +LRH +V Sbjct: 278 KLGQGCFGEVWMGTWNGTTKVAIKTLK-------LGTMMPEAFLQEAQIMKKLRHDKLVP 330 Query: 808 FVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGIL 987 A + P++ I+TE+M+ GSL +L + + + + ++ +A IA GM+Y+ + Sbjct: 331 LYAVVSEEPIY-IVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYI 389 Query: 988 HRDLKSENVLLGEDMSVKVADFGISCL--ESQCGSGKGFTGTYRWMAPEMIKEKNHTRKV 1161 HRDL++ N+L+GE++ K+ADFG++ L +++ + +G +W APE T K Sbjct: 390 HRDLRAANILVGENLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKS 449 Query: 1162 DVYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATN 1338 DV+SFGI+ E+ T VP+ M + V + R P P CP ++ L++ CW + Sbjct: 450 DVWSFGILQTELTTKGRVPYPGMVNREVLEQVE-RGYRMPCPQGCPESLHELMNLCWKKD 508 Query: 1339 PDKRPQFDDIVVVLEGYKEALD 1404 PD+RP F+ I LE Y A + Sbjct: 509 PDERPTFEYIQSFLEDYFTAAE 530
>P11346:KRAF1_DROME Raf homolog serine/threonine-protein kinase dRAF-1 - Drosophila| melanogaster (Fruit fly) Length = 739 Score = 137 bits (346), Expect = 1e-31 Identities = 87/267 (32%), Positives = 143/267 (53%), Gaps = 10/267 (3%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGREVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSF 810 R SG VY ++G VA+K ++ A + F +EVA+L + RH NI+ F Sbjct: 434 RIGSGSFGTVYRAHWHG-PVAVKTLNVKTPSPAQL----QAFKNEVAMLKKTRHCNILLF 488 Query: 811 VAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGILH 990 + KP + I+T++ G SL K++H E + ++ + +A+GM YLH++ I+H Sbjct: 489 MGCVSKPSL-AIVTQWCEGSSLYKHVHVSET-KFKLNTLIDIGRQVAQGMDYLHAKNIIH 546 Query: 991 RDLKSENVLLGEDMSVKVADFGISCLESQCGSGKGF---TGTYRWMAPEMIKEKN---HT 1152 RDLKS N+ L ED+SVK+ DFG++ +++ K TG+ WMAPE+I+ + ++ Sbjct: 547 RDLKSNNIFLHEDLSVKIGDFGLATAKTRWSGEKQANQPTGSILWMAPEVIRMQELNPYS 606 Query: 1153 RKVDVYSFGIVLWEILTALVPFSEMT-PEQAAIAVALKNARPPLP---ASCPVAMSHLIS 1320 + DVY+FGIV++E+L +P+ ++ +Q V RP + + P A+ L Sbjct: 607 FQSDVYAFGIVMYELLAECLPYGHISNKDQILFMVGRGLLRPDMSQVRSDAPQALKRLAE 666 Query: 1321 QCWATNPDKRPQFDDIVVVLEGYKEAL 1401 C P RP F ++ +LE L Sbjct: 667 DCIKYTPKDRPLFRPLLNMLENMLRTL 693
>Q04736:YES_MOUSE Proto-oncogene tyrosine-protein kinase Yes - Mus musculus (Mouse)| Length = 541 Score = 137 bits (344), Expect = 2e-31 Identities = 82/262 (31%), Positives = 139/262 (53%), Gaps = 4/262 (1%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGR-EVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVS 807 + G V+ G +NG +VAIK + + F E ++ +LRH +V Sbjct: 280 KLGQGCFGEVWMGTWNGTTKVAIKTLKP-------GTMMPEAFLQEAQIMKKLRHDKLVP 332 Query: 808 FVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGIL 987 A + P++ I+TE+M+ GSL +L + + + + ++ +A IA GM+Y+ + Sbjct: 333 LYAVVSEEPIY-IVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYI 391 Query: 988 HRDLKSENVLLGEDMSVKVADFGISCL--ESQCGSGKGFTGTYRWMAPEMIKEKNHTRKV 1161 HRDL++ N+L+GE++ K+ADFG++ L +++ + +G +W APE T K Sbjct: 392 HRDLRAANILVGENLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKS 451 Query: 1162 DVYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATN 1338 DV+SFGI+ E++T VP+ M + V + R P P CP ++ L++ CW + Sbjct: 452 DVWSFGILQTELVTKGRVPYPGMVNREVLEQVE-RGYRMPCPQGCPESLHELMNLCWKKD 510 Query: 1339 PDKRPQFDDIVVVLEGYKEALD 1404 PD+RP F+ I LE Y A + Sbjct: 511 PDERPTFEYIQSFLEDYFTATE 532
>P07947:YES_HUMAN Proto-oncogene tyrosine-protein kinase Yes - Homo sapiens (Human)| Length = 543 Score = 137 bits (344), Expect = 2e-31 Identities = 82/262 (31%), Positives = 139/262 (53%), Gaps = 4/262 (1%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGR-EVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVS 807 + G V+ G +NG +VAIK + + F E ++ +LRH +V Sbjct: 282 KLGQGCFGEVWMGTWNGTTKVAIKTLKP-------GTMMPEAFLQEAQIMKKLRHDKLVP 334 Query: 808 FVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGIL 987 A + P++ I+TE+M+ GSL +L + + + + ++ +A IA GM+Y+ + Sbjct: 335 LYAVVSEEPIY-IVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYI 393 Query: 988 HRDLKSENVLLGEDMSVKVADFGISCL--ESQCGSGKGFTGTYRWMAPEMIKEKNHTRKV 1161 HRDL++ N+L+GE++ K+ADFG++ L +++ + +G +W APE T K Sbjct: 394 HRDLRAANILVGENLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKS 453 Query: 1162 DVYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATN 1338 DV+SFGI+ E++T VP+ M + V + R P P CP ++ L++ CW + Sbjct: 454 DVWSFGILQTELVTKGRVPYPGMVNREVLEQVE-RGYRMPCPQGCPESLHELMNLCWKKD 512 Query: 1339 PDKRPQFDDIVVVLEGYKEALD 1404 PD+RP F+ I LE Y A + Sbjct: 513 PDERPTFEYIQSFLEDYFTATE 534
>P13116:SRC2_XENLA Tyrosine-protein kinase Src-2 - Xenopus laevis (African clawed frog)| Length = 532 Score = 137 bits (344), Expect = 2e-31 Identities = 85/262 (32%), Positives = 140/262 (53%), Gaps = 4/262 (1%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGR-EVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVS 807 + G V+ G +NG VAIK + + ++ E F E ++ +LRH +V Sbjct: 271 KLGQGCFGEVWMGTWNGTTRVAIKTL----KPGTMSPEA---FLQEAQVMKKLRHEKLVQ 323 Query: 808 FVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGIL 987 A + P++ I+TEYM+ GSL +L + + + ++ +A IA GM+Y+ + Sbjct: 324 LYAVVSEEPIY-IVTEYMSKGSLLDFLKGEMGRYLRLPQLVDMAAQIASGMAYVERMNYV 382 Query: 988 HRDLKSENVLLGEDMSVKVADFGISCL--ESQCGSGKGFTGTYRWMAPEMIKEKNHTRKV 1161 HRDL++ N+L+GE++ KVADFG++ L +++ + +G +W APE T K Sbjct: 383 HRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKS 442 Query: 1162 DVYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATN 1338 DV+SFGI+L E+ T VP+ M + V + R P P CP ++ L+ QCW + Sbjct: 443 DVWSFGILLTELTTKGRVPYPGMVNREVLDQVE-RGYRMPCPPDCPESLHDLMFQCWRKD 501 Query: 1339 PDKRPQFDDIVVVLEGYKEALD 1404 P++RP F+ + LE Y A + Sbjct: 502 PEERPTFEYLQAFLEDYFTATE 523
>Q05876:FYN_CHICK Proto-oncogene tyrosine-protein kinase Fyn - Gallus gallus (Chicken)| Length = 534 Score = 137 bits (344), Expect = 2e-31 Identities = 82/262 (31%), Positives = 142/262 (54%), Gaps = 4/262 (1%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGR-EVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVS 807 + G + V+ G +NG +VAIK + + ++ E F E ++ +L+H +V Sbjct: 273 KLGQGCFAEVWRGTWNGNTKVAIKTL----KPGTMSPE---SFLEEAQIMKKLKHDKLVQ 325 Query: 808 FVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGIL 987 A + P++ I+TEYM+ GSL +L E ++ + ++ +A +A GM+Y+ + Sbjct: 326 LYAVVSRRPIY-IVTEYMSKGSLLIFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYI 384 Query: 988 HRDLKSENVLLGEDMSVKVADFGISCL--ESQCGSGKGFTGTYRWMAPEMIKEKNHTRKV 1161 HRDL+S N+L+G + K+ADFG++ L +++ + +G +W APE T K Sbjct: 385 HRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKS 444 Query: 1162 DVYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATN 1338 DV+SFGI+L E++T VP+ M + V + R P P CP+++ L+ CW + Sbjct: 445 DVWSFGILLTELVTKGRVPYPGMNNREVLEQVE-RGYRMPCPQDCPISLHELMIHCWKKD 503 Query: 1339 PDKRPQFDDIVVVLEGYKEALD 1404 P++RP F+ + LE Y A + Sbjct: 504 PEERPTFEYLQGFLEDYFTATE 525
>P03949:ABL1_CAEEL Tyrosine-protein kinase abl-1 - Caenorhabditis elegans| Length = 1224 Score = 137 bits (344), Expect = 2e-31 Identities = 84/255 (32%), Positives = 137/255 (53%), Gaps = 4/255 (1%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGREVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSF 810 + G++ VY G + + I + + ++DA+ +F +E A++ L H N+V Sbjct: 316 KLGGGQYGDVYEGYWKRHDCTIAVKAL--KEDAMPLH---EFLAEAAIMKDLHHKNLVRL 370 Query: 811 VAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGILH 990 + C F IITE+M G+L +YL + + +P +++Q+A IA GMSYL ++ +H Sbjct: 371 LGVCTHEAPFYIITEFMCNGNLLEYLRRTDKSLLPPIILVQMASQIASGMSYLEARHFIH 430 Query: 991 RDLKSENVLLGEDMSVKVADFGIS--CLESQCGSGKGFTGTYRWMAPEMIKEKNHTRKVD 1164 RDL + N L+ E VK+ADFG++ E + G +W APE + + K D Sbjct: 431 RDLAARNCLVSEHNIVKIADFGLARFMKEDTYTAHAGAKFPIKWTAPEGLAFNTFSSKSD 490 Query: 1165 VYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNA-RPPLPASCPVAMSHLISQCWATN 1338 V++FG++LWEI T + P+ + E + + L+N R P CP ++ L+ QCW + Sbjct: 491 VWAFGVLLWEIATYGMAPYPGV--ELSNVYGLLENGFRMDGPQGCPPSVYRLMLQCWNWS 548 Query: 1339 PDKRPQFDDIVVVLE 1383 P RP+F DI LE Sbjct: 549 PSDRPRFRDIHFNLE 563
>P12931:SRC_HUMAN Proto-oncogene tyrosine-protein kinase Src - Homo sapiens (Human)| Length = 536 Score = 136 bits (343), Expect = 3e-31 Identities = 84/257 (32%), Positives = 137/257 (53%), Gaps = 4/257 (1%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGR-EVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVS 807 + G V+ G +NG VAIK + + ++ E F E ++ +LRH +V Sbjct: 275 KLGQGCFGEVWMGTWNGTTRVAIKTL----KPGTMSPEA---FLQEAQVMKKLRHEKLVQ 327 Query: 808 FVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGIL 987 A + P++ I+TEYM+ GSL +L + + + ++ +A IA GM+Y+ + Sbjct: 328 LYAVVSEEPIY-IVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYV 386 Query: 988 HRDLKSENVLLGEDMSVKVADFGISCL--ESQCGSGKGFTGTYRWMAPEMIKEKNHTRKV 1161 HRDL++ N+L+GE++ KVADFG++ L +++ + +G +W APE T K Sbjct: 387 HRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKS 446 Query: 1162 DVYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATN 1338 DV+SFGI+L E+ T VP+ M + V + R P P CP ++ L+ QCW Sbjct: 447 DVWSFGILLTELTTKGRVPYPGMVNREVLDQVE-RGYRMPCPPECPESLHDLMCQCWRKE 505 Query: 1339 PDKRPQFDDIVVVLEGY 1389 P++RP F+ + LE Y Sbjct: 506 PEERPTFEYLQAFLEDY 522
>P00523:SRC_CHICK Proto-oncogene tyrosine-protein kinase Src - Gallus gallus (Chicken)| Length = 533 Score = 136 bits (343), Expect = 3e-31 Identities = 84/257 (32%), Positives = 138/257 (53%), Gaps = 4/257 (1%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGR-EVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVS 807 + G V+ G +NG VAIK + + ++ E F E ++ +LRH +V Sbjct: 272 KLGQGCFGEVWMGTWNGTTRVAIKTL----KPGTMSPEA---FLQEAQVMKKLRHEKLVQ 324 Query: 808 FVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGIL 987 A + P++ I+TEYM+ GSL +L + + + ++ +A IA GM+Y+ + Sbjct: 325 LYAVVSEEPIY-IVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERMNYV 383 Query: 988 HRDLKSENVLLGEDMSVKVADFGISCL--ESQCGSGKGFTGTYRWMAPEMIKEKNHTRKV 1161 HRDL++ N+L+GE++ KVADFG++ L +++ + +G +W APE T K Sbjct: 384 HRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKS 443 Query: 1162 DVYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATN 1338 DV+SFGI+L E+ T VP+ M + V + R P P CP ++ L+ QCW + Sbjct: 444 DVWSFGILLTELTTKGRVPYPGMVNREVLDQVE-RGYRMPCPPECPESLHDLMCQCWRKD 502 Query: 1339 PDKRPQFDDIVVVLEGY 1389 P++RP F+ + LE Y Sbjct: 503 PEERPTFEYLQAFLEDY 519
>P14085:SRC_AVIST Tyrosine-protein kinase transforming protein Src - Avian sarcoma| virus (strain S2) Length = 557 Score = 136 bits (343), Expect = 3e-31 Identities = 84/257 (32%), Positives = 138/257 (53%), Gaps = 4/257 (1%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGR-EVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVS 807 + G V+ G +NG VAIK + + ++ E F E ++ +LRH +V Sbjct: 272 KLGQGCFGEVWMGTWNGTTRVAIKTL----KPGTMSPEA---FLQEAQVMKKLRHEKLVQ 324 Query: 808 FVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGIL 987 A + P++ I+TEYM+ GSL +L + + + ++ +A IA GM+Y+ + Sbjct: 325 LYAVVSEEPIY-IVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERMNYV 383 Query: 988 HRDLKSENVLLGEDMSVKVADFGISCL--ESQCGSGKGFTGTYRWMAPEMIKEKNHTRKV 1161 HRDL++ N+L+GE++ KVADFG++ L +++ + +G +W APE T K Sbjct: 384 HRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKS 443 Query: 1162 DVYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATN 1338 DV+SFGI+L E+ T VP+ M + V + R P P CP ++ L+ QCW + Sbjct: 444 DVWSFGILLTELTTKGRVPYPGMVNREVLDQVE-RGYRMPCPPECPESLHDLMCQCWRKD 502 Query: 1339 PDKRPQFDDIVVVLEGY 1389 P++RP F+ + LE Y Sbjct: 503 PEERPTFEYLQAFLEDY 519
>P15054:SRC_AVIS2 Tyrosine-protein kinase transforming protein Src - Avian sarcoma| virus (strain PR2257) Length = 587 Score = 136 bits (343), Expect = 3e-31 Identities = 84/257 (32%), Positives = 138/257 (53%), Gaps = 4/257 (1%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGR-EVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVS 807 + G V+ G +NG VAIK + + ++ E F E ++ +LRH +V Sbjct: 272 KLGQGCFGEVWMGTWNGTTRVAIKTL----KPGTMSPEA---FLQEAQVMKKLRHEKLVQ 324 Query: 808 FVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGIL 987 A + P++ I+TEYM+ GSL +L + + + ++ +A IA GM+Y+ + Sbjct: 325 LYAVVSEEPIY-IVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERMNYV 383 Query: 988 HRDLKSENVLLGEDMSVKVADFGISCL--ESQCGSGKGFTGTYRWMAPEMIKEKNHTRKV 1161 HRDL++ N+L+GE++ KVADFG++ L +++ + +G +W APE T K Sbjct: 384 HRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKS 443 Query: 1162 DVYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATN 1338 DV+SFGI+L E+ T VP+ M + V + R P P CP ++ L+ QCW + Sbjct: 444 DVWSFGILLTELTTKGRVPYPGMVNREVLDQVE-RGYRMPCPPECPESLHDLMCQCWRKD 502 Query: 1339 PDKRPQFDDIVVVLEGY 1389 P++RP F+ + LE Y Sbjct: 503 PEERPTFEYLQAFLEDY 519
>Q13882:PTK6_HUMAN Tyrosine-protein kinase 6 - Homo sapiens (Human)| Length = 451 Score = 136 bits (343), Expect = 3e-31 Identities = 83/246 (33%), Positives = 134/246 (54%), Gaps = 3/246 (1%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGR-EVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVS 807 + SG V+ G + R +VAIK++S+ D+ L ++ SE+ + +LRH +I++ Sbjct: 196 KLGSGYFGEVFEGLWKDRVQVAIKVISR---DNLLHQQM---LQSEIQAMKKLRHKHILA 249 Query: 808 FVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGIL 987 A IITE MA GSL + L + +P+ +L +A +A GM YL SQ + Sbjct: 250 LYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLESQNYI 309 Query: 988 HRDLKSENVLLGEDMSVKVADFGIS-CLESQCGSGKGFTGTYRWMAPEMIKEKNHTRKVD 1164 HRDL + N+L+GE+ KV DFG++ ++ Y+W APE + +++ K D Sbjct: 310 HRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPEALSRGHYSTKSD 369 Query: 1165 VYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATNP 1341 V+SFGI+L E+ + VP+ M+ +A + V R P P CP ++ L+ CW +P Sbjct: 370 VWSFGILLHEMFSRGQVPYPGMSNHEAFLRVD-AGYRMPCPLECPPSVHKLMLTCWCRDP 428 Query: 1342 DKRPQF 1359 ++RP F Sbjct: 429 EQRPCF 434
>P14084:SRC_AVISS Tyrosine-protein kinase transforming protein Src - Avian sarcoma| virus (strain S1) Length = 568 Score = 136 bits (342), Expect = 3e-31 Identities = 84/257 (32%), Positives = 138/257 (53%), Gaps = 4/257 (1%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGR-EVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVS 807 + G V+ G +NG VAIK + + ++ E F E ++ +LRH +V Sbjct: 272 KLGQGCFGEVWMGTWNGTTRVAIKTL----KPGTMSPEA---FLQEAQVMKKLRHEKLVR 324 Query: 808 FVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGIL 987 A + P++ I+TEYM+ GSL +L + + + ++ +A IA GM+Y+ + Sbjct: 325 LYAVVSEEPIY-IVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERMNYV 383 Query: 988 HRDLKSENVLLGEDMSVKVADFGISCL--ESQCGSGKGFTGTYRWMAPEMIKEKNHTRKV 1161 HRDL++ N+L+GE++ KVADFG++ L +++ + +G +W APE T K Sbjct: 384 HRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKS 443 Query: 1162 DVYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATN 1338 DV+SFGI+L E+ T VP+ M + V + R P P CP ++ L+ QCW + Sbjct: 444 DVWSFGILLTELTTKGRVPYPGMVNREVLDQVE-RGYRMPCPPECPESLHDLMCQCWRKD 502 Query: 1339 PDKRPQFDDIVVVLEGY 1389 P++RP F+ + LE Y Sbjct: 503 PEERPTFEYLQAFLEDY 519
>P09560:RAF1_XENLA RAF proto-oncogene serine/threonine-protein kinase - Xenopus laevis| (African clawed frog) Length = 638 Score = 136 bits (342), Expect = 3e-31 Identities = 89/269 (33%), Positives = 151/269 (56%), Gaps = 12/269 (4%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGREVAIKM--VSQPHEDDALAAELERQFASEVALLLRLRHHNIV 804 R SG VY G+++G +VA+K+ V+ P + A F +EVA+L + RH NI+ Sbjct: 345 RIGSGSFGTVYKGKWHG-DVAVKILKVTDPTPEQLQA------FRNEVAVLRKTRHVNIL 397 Query: 805 SFVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGI 984 F+ K + I+T++ G SL +LH + QL+ +A A+GM YLH++ I Sbjct: 398 LFMGYMTKDNL-AIVTQWCEGSSLYYHLHVLDTKFQMFQLI-DIARQTAQGMDYLHAKNI 455 Query: 985 LHRDLKSENVLLGEDMSVKVADFGISCLESQCGSG---KGFTGTYRWMAPEMIKEKNH-- 1149 +HRD+KS N+ L E ++VK+ DFG++ ++++ + TG+ WMAPE+I+ +++ Sbjct: 456 IHRDMKSNNIFLHEGLTVKIGDFGLATVKTRWSGSQQVEQLTGSILWMAPEVIRMQDNNP 515 Query: 1150 -TRKVDVYSFGIVLWEILTALVPFSEMTPEQAAIAVALKNARPP----LPASCPVAMSHL 1314 + + DVYS+GIVL+E++T +P+S + I + + P L +CP AM L Sbjct: 516 FSFQSDVYSYGIVLYELMTGELPYSHIRDRDQIIFLVGRGGVVPDLSKLYKNCPKAMKRL 575 Query: 1315 ISQCWATNPDKRPQFDDIVVVLEGYKEAL 1401 ++ D+RP F I+ +E + +L Sbjct: 576 VADSIKKLRDERPLFPQILSSIELLQHSL 604
>P00522:ABL_DROME Tyrosine-protein kinase Abl - Drosophila melanogaster (Fruit fly)| Length = 1620 Score = 136 bits (342), Expect = 3e-31 Identities = 85/259 (32%), Positives = 135/259 (52%), Gaps = 8/259 (3%) Frame = +1 Query: 631 RFASGRHSRVY---FGRYNGREVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNI 801 + G++ VY + RY G VA+K + ++D +A + F E A++ ++H N+ Sbjct: 376 KLGGGQYGEVYEAVWKRY-GNTVAVKTL----KEDTMAL---KDFLEEAAIMKEMKHPNL 427 Query: 802 VSFVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQG 981 V + C + P F IITE+M+ G+L +L ++ +L +A IA GMSYL S+ Sbjct: 428 VQLIGVCTREPPFYIITEFMSHGNLLDFLRSAGRETLDAVALLYMATQIASGMSYLESRN 487 Query: 982 ILHRDLKSENVLLGEDMSVKVADFGISCL--ESQCGSGKGFTGTYRWMAPEMIKEKNHTR 1155 +HRDL + N L+G++ VKVADFG++ L + + G +W APE + + Sbjct: 488 YIHRDLAARNCLVGDNKLVKVADFGLARLMRDDTYTAHAGAKFPIKWTAPEGLAYNKFST 547 Query: 1156 KVDVYSFGIVLWEILT---ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQC 1326 K DV++FG++LWEI T + P ++T + + RPP CP + L+ QC Sbjct: 548 KSDVWAFGVLLWEIATYGMSPYPAIDLTDVYHKLDKGYRMERPP---GCPPEVYDLMRQC 604 Query: 1327 WATNPDKRPQFDDIVVVLE 1383 W + RP F I LE Sbjct: 605 WQWDATDRPTFKSIHHALE 623
>P13115:SRC1_XENLA Tyrosine-protein kinase Src-1 - Xenopus laevis (African clawed frog)| Length = 532 Score = 135 bits (341), Expect = 4e-31 Identities = 90/283 (31%), Positives = 146/283 (51%), Gaps = 4/283 (1%) Frame = +1 Query: 568 QDPGRRRGALERRPLKARDPGRFASGRHSRVYFGRYNGR-EVAIKMVSQPHEDDALAAEL 744 Q G R A E R + G V+ G +NG VAIK + + ++ E Sbjct: 250 QTQGLSRDAWEIPRDSLRLELKLGQGCFGEVWMGTWNGTTRVAIKTL----KPGTMSPEA 305 Query: 745 ERQFASEVALLLRLRHHNIVSFVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQL 924 F E ++ +LRH +V A + P++ I+TEY++ GSL +L + + + Sbjct: 306 ---FLQEAQVMKKLRHEKLVQLYAVVSEEPIY-IVTEYISKGSLLDFLKGEMGRYLRLPQ 361 Query: 925 VLQLALDIARGMSYLHSQGILHRDLKSENVLLGEDMSVKVADFGISCL--ESQCGSGKGF 1098 ++ +A IA GM+Y+ +HRDL++ N+L+GE++ KVADFG++ L +++ + +G Sbjct: 362 LVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGA 421 Query: 1099 TGTYRWMAPEMIKEKNHTRKVDVYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARP 1275 +W APE T K DV+SFGI+L E+ T VP+ M + V + R Sbjct: 422 KFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVE-RGYRM 480 Query: 1276 PLPASCPVAMSHLISQCWATNPDKRPQFDDIVVVLEGYKEALD 1404 P P CP ++ L+ QCW +P++RP F+ + LE Y A + Sbjct: 481 PCPPDCPESLHDLMFQCWRKDPEERPTFEYLQAFLEDYFTATE 523
>Q95M30:HCK_MACFA Tyrosine-protein kinase HCK - Macaca fascicularis (Crab eating| macaque) (Cynomolgus monkey) Length = 504 Score = 135 bits (341), Expect = 4e-31 Identities = 80/263 (30%), Positives = 146/263 (55%), Gaps = 4/263 (1%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGR-EVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVS 807 + +G+ V+ YN +VA+K + + +++ E F +E L+ L+H +V Sbjct: 245 KLGAGQFGEVWMATYNKHTKVAVKTM----KPGSMSVEA---FLAEANLMKTLQHDKLVK 297 Query: 808 FVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGIL 987 A K P++ IITE+MA GSL +L E P+ ++ + IA GM+++ + + Sbjct: 298 LHAVVTKEPIY-IITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYI 356 Query: 988 HRDLKSENVLLGEDMSVKVADFGISCL--ESQCGSGKGFTGTYRWMAPEMIKEKNHTRKV 1161 HRDL++ N+L+ + K+ADFG++ + +++ + +G +W APE I + T K Sbjct: 357 HRDLRAANILVSASLVCKIADFGLARIIEDNEYTAREGAKFPIKWTAPEAINFGSSTIKS 416 Query: 1162 DVYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATN 1338 DV+SFGI+L EI+T +P+ M+ + A+ + R P P +CP + +++ +CW Sbjct: 417 DVWSFGILLMEIVTYGRIPYPGMSNPEVIRALE-RGYRMPRPENCPEELYNIMMRCWKNR 475 Query: 1339 PDKRPQFDDIVVVLEGYKEALDN 1407 P++RP F+ I VL+ + A ++ Sbjct: 476 PEERPTFEYIQSVLDDFYTATES 498
>P00521:ABL_MLVAB Tyrosine-protein kinase transforming protein Abl - Abelson murine| leukemia virus Length = 746 Score = 135 bits (341), Expect = 4e-31 Identities = 79/249 (31%), Positives = 130/249 (52%), Gaps = 3/249 (1%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGREVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSF 810 + G++ VY G + ++ ++ + + ++D + E +F E A++ ++H N+V Sbjct: 133 KLGGGQYGEVYEGVW--KKYSLTVAVKTLKEDTMEVE---EFLKEAAVMKEIKHPNLVQL 187 Query: 811 VAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGILH 990 + C + P F IITE+M G+L YL + V ++L +A I+ M YL + +H Sbjct: 188 LGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVSAVVLLYMATQISSAMEYLEKKNFIH 247 Query: 991 RDLKSENVLLGEDMSVKVADFGISCLES--QCGSGKGFTGTYRWMAPEMIKEKNHTRKVD 1164 RDL + N L+GE+ VKVADFG+S L + + G +W APE + + K D Sbjct: 248 RDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSD 307 Query: 1165 VYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATNP 1341 V++FG++LWEI T + P+ + Q + K+ R P CP + L+ CW NP Sbjct: 308 VWAFGVLLWEIATYGMSPYPGIDLSQ-VYELLEKDYRMERPEGCPEKVYELMRACWQWNP 366 Query: 1342 DKRPQFDDI 1368 RP F +I Sbjct: 367 SDRPSFAEI 375
>P00520:ABL1_MOUSE Proto-oncogene tyrosine-protein kinase ABL1 - Mus musculus (Mouse)| Length = 1123 Score = 135 bits (341), Expect = 4e-31 Identities = 79/249 (31%), Positives = 130/249 (52%), Gaps = 3/249 (1%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGREVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSF 810 + G++ VY G + ++ ++ + + ++D + E +F E A++ ++H N+V Sbjct: 247 KLGGGQYGEVYEGVW--KKYSLTVAVKTLKEDTMEVE---EFLKEAAVMKEIKHPNLVQL 301 Query: 811 VAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGILH 990 + C + P F IITE+M G+L YL + V ++L +A I+ M YL + +H Sbjct: 302 LGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVSAVVLLYMATQISSAMEYLEKKNFIH 361 Query: 991 RDLKSENVLLGEDMSVKVADFGISCLES--QCGSGKGFTGTYRWMAPEMIKEKNHTRKVD 1164 RDL + N L+GE+ VKVADFG+S L + + G +W APE + + K D Sbjct: 362 RDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSD 421 Query: 1165 VYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATNP 1341 V++FG++LWEI T + P+ + Q + K+ R P CP + L+ CW NP Sbjct: 422 VWAFGVLLWEIATYGMSPYPGIDLSQ-VYELLEKDYRMERPEGCPEKVYELMRACWQWNP 480 Query: 1342 DKRPQFDDI 1368 RP F +I Sbjct: 481 SDRPSFAEI 489
>P10936:YES_XENLA Tyrosine-protein kinase Yes - Xenopus laevis (African clawed frog)| Length = 537 Score = 135 bits (340), Expect = 6e-31 Identities = 82/262 (31%), Positives = 136/262 (51%), Gaps = 4/262 (1%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGR-EVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVS 807 + G V+ G +NG +VAIK + + F E ++ +LRH +V Sbjct: 276 KLGQGCFGEVWIGTWNGTTKVAIKTLKP-------GTMMPEAFLQEAQIMKKLRHDKLVP 328 Query: 808 FVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGIL 987 A + P++ I+TEYM GSL +L + + + ++ +A IA GM+Y+ + Sbjct: 329 LYAVVSEEPIY-IVTEYMIKGSLLDFLKEGNGKYLKLPQLVDMAAQIADGMAYIERMNYI 387 Query: 988 HRDLKSENVLLGEDMSVKVADFGISCL--ESQCGSGKGFTGTYRWMAPEMIKEKNHTRKV 1161 HRDL++ N+L+G+++ K+ADFG++ L +++ + +G +W APE T K Sbjct: 388 HRDLRAANILVGDNLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKS 447 Query: 1162 DVYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATN 1338 DV+SFGI+L E++ VP+ M + V + R P P CP ++ L+ CW + Sbjct: 448 DVWSFGILLTELVAKGRVPYPGMVNREVLEQVE-RGYRMPCPQRCPESLHELMKLCWKKD 506 Query: 1339 PDKRPQFDDIVVVLEGYKEALD 1404 PD+RP F+ I LE Y A + Sbjct: 507 PDERPTFEYIQSFLEDYFTATE 528
>Q07497:EPHB5_CHICK Ephrin type-B receptor 5 precursor - Gallus gallus (Chicken)| Length = 1002 Score = 135 bits (340), Expect = 6e-31 Identities = 86/260 (33%), Positives = 134/260 (51%), Gaps = 12/260 (4%) Frame = +1 Query: 640 SGRHSRVYFGR--YNGRE---VAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIV 804 SG V FGR + G+ VAIK + + D E R+F SE +++ + H N++ Sbjct: 645 SGEFGEVCFGRLKHPGKREYTVAIKTLKSGYTD-----EQRREFLSEASIMGQFEHPNVI 699 Query: 805 SFVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGI 984 K I+TE+M GSL +L Q+E +QLV L IA GM YL Sbjct: 700 HLEGVVTKSRPVMIVTEFMENGSLDSFLRQKEGQFSVLQLVGMLR-GIAAGMRYLSDMNY 758 Query: 985 LHRDLKSENVLLGEDMSVKVADFGISCLESQCGSGKGFTGT------YRWMAPEMIKEKN 1146 +HRDL + N+L+ ++ KV+DFG+S S +TG RW APE ++ + Sbjct: 759 VHRDLAARNILVNSNLVCKVSDFGLSRFLEDDASNPTYTGALGCKIPIRWTAPEAVQYRK 818 Query: 1147 HTRKVDVYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQ 1323 T DV+S+GIV+WE+++ P+ +M+ + A+ ++ R P P CP + L+ Sbjct: 819 FTSSSDVWSYGIVMWEVMSYGERPYWDMSNQDVINAID-QDYRLPPPPDCPTVLHLLMLD 877 Query: 1324 CWATNPDKRPQFDDIVVVLE 1383 CW + +RP+F+ IV L+ Sbjct: 878 CWQKDRVQRPKFEQIVSALD 897
>P51451:BLK_HUMAN Tyrosine-protein kinase BLK - Homo sapiens (Human)| Length = 505 Score = 135 bits (340), Expect = 6e-31 Identities = 85/263 (32%), Positives = 145/263 (55%), Gaps = 5/263 (1%) Frame = +1 Query: 631 RFASGRHSRVYFGRY-NGREVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVS 807 + SG+ V+ G Y N +VAIK + ++ ++ E F E ++ L+H +V Sbjct: 246 KLGSGQFGEVWMGYYKNNMKVAIKTL----KEGTMSPEA---FLGEANMMKALQHERLVR 298 Query: 808 FVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGIL 987 A K P++ I+TEYMA G L +L E + + ++ ++ IA GM+Y+ + Sbjct: 299 LYAVVTKEPIY-IVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGMAYIERMNSI 357 Query: 988 HRDLKSENVLLGEDMSVKVADFGIS-CLESQCGSGKGFTGTYRWMAPEMIKEKNHTRKVD 1164 HRDL++ N+L+ E + K+ADFG++ ++S+ + +G +W APE I T K D Sbjct: 358 HRDLRAANILVSEALCCKIADFGLARIIDSEYTAQEGAKFPIKWTAPEAIHFGVFTIKAD 417 Query: 1165 VYSFGIVLWEILT-ALVPFSEMT-PEQAAIAVALKNARPPLPASCPVAMSH-LISQCWAT 1335 V+SFG++L E++T VP+ M+ PE I + R P P +CP + +I++CW + Sbjct: 418 VWSFGVLLMEVVTYGRVPYPGMSNPE--VIRNLERGYRMPRPDTCPPELYRGVIAECWRS 475 Query: 1336 NPDKRPQFDDIVVVLEGYKEALD 1404 P++RP F+ + VLE + A + Sbjct: 476 RPEERPTFEFLQSVLEDFYTATE 498
>P00519:ABL1_HUMAN Proto-oncogene tyrosine-protein kinase ABL1 - Homo sapiens (Human)| Length = 1130 Score = 135 bits (340), Expect = 6e-31 Identities = 79/249 (31%), Positives = 130/249 (52%), Gaps = 3/249 (1%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGREVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSF 810 + G++ VY G + ++ ++ + + ++D + E +F E A++ ++H N+V Sbjct: 247 KLGGGQYGEVYEGVW--KKYSLTVAVKTLKEDTMEVE---EFLKEAAVMKEIKHPNLVQL 301 Query: 811 VAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGILH 990 + C + P F IITE+M G+L YL + V ++L +A I+ M YL + +H Sbjct: 302 LGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIH 361 Query: 991 RDLKSENVLLGEDMSVKVADFGISCLES--QCGSGKGFTGTYRWMAPEMIKEKNHTRKVD 1164 RDL + N L+GE+ VKVADFG+S L + + G +W APE + + K D Sbjct: 362 RDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSD 421 Query: 1165 VYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATNP 1341 V++FG++LWEI T + P+ + Q + K+ R P CP + L+ CW NP Sbjct: 422 VWAFGVLLWEIATYGMSPYPGIDLSQ-VYELLEKDYRMERPEGCPEKVYELMRACWQWNP 480 Query: 1342 DKRPQFDDI 1368 RP F +I Sbjct: 481 SDRPSFAEI 489
>P41239:CSK_CHICK Tyrosine-protein kinase CSK - Gallus gallus (Chicken)| Length = 450 Score = 135 bits (339), Expect = 7e-31 Identities = 93/281 (33%), Positives = 142/281 (50%), Gaps = 5/281 (1%) Frame = +1 Query: 568 QDPGRRRG-ALERRPLKARDPGRFASGRHSRVYFGRYNGREVAIKMVSQPHEDDALAAEL 744 QD R G AL + LK G V G Y G +VA+K + ++DA A Sbjct: 180 QDEFSRSGWALNMKDLKLLQI--IGKGEFGDVMLGDYRGNKVAVKCI----KNDATA--- 230 Query: 745 ERQFASEVALLLRLRHHNIVSFVAAC-KKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQ 921 + F +E +++ +LRH N+V + ++ I+TEYMA GSL YL + + Sbjct: 231 -QAFLAEASVMTQLRHSNLVQLLGVIVEEKSGLYIVTEYMAKGSLVDYLRSRGRSVLGGD 289 Query: 922 LVLQLALDIARGMSYLHSQGILHRDLKSENVLLGEDMSVKVADFGISCLESQCGSGKGFT 1101 +L+ +LD+ M YL + +HRDL + NVL+ ED KV+DFG+ ++ S T Sbjct: 290 CLLKFSLDVCEAMEYLEANNFVHRDLAARNVLVSEDNIAKVSDFGL----TKEASSTQDT 345 Query: 1102 G--TYRWMAPEMIKEKNHTRKVDVYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNAR 1272 G +W APE ++EK + K DV+SFGI+LWEI + VP+ + P + + K + Sbjct: 346 GKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRI-PLKDVVPRVEKGYK 404 Query: 1273 PPLPASCPVAMSHLISQCWATNPDKRPQFDDIVVVLEGYKE 1395 P CP + ++ +CW +P RP F + L KE Sbjct: 405 MDPPDGCPAIVYEVMKKCWTLDPGHRPSFHQLREQLVHIKE 445
>P10447:ABL_FSVHY Tyrosine-protein kinase transforming protein Abl - Feline sarcoma| virus (strain Hardy-Zuckerman 2) Length = 439 Score = 135 bits (339), Expect = 7e-31 Identities = 79/249 (31%), Positives = 130/249 (52%), Gaps = 3/249 (1%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGREVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSF 810 + G++ VY G + ++ ++ + + ++D + E +F E A++ ++H N+V Sbjct: 196 KLGGGQYGEVYEGVW--KKYSLTVAVKTLKEDTMEVE---EFLKEAAVMKEIKHPNLVQL 250 Query: 811 VAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGILH 990 + C + P F IITE+M G+L YL + V ++L +A I+ M YL + +H Sbjct: 251 LGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIH 310 Query: 991 RDLKSENVLLGEDMSVKVADFGISCLES--QCGSGKGFTGTYRWMAPEMIKEKNHTRKVD 1164 RDL + N L+GE+ VKVADFG+S L + + G +W APE + + K D Sbjct: 311 RDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGTKFPIKWTAPESLAYNKFSIKSD 370 Query: 1165 VYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATNP 1341 V++FG++LWEI T + P+ + Q + K+ R P CP + L+ CW NP Sbjct: 371 VWAFGVLLWEIATYGMSPYPGIDLSQ-VYELLEKDYRMERPEGCPEKVYELMRACWQWNP 429 Query: 1342 DKRPQFDDI 1368 RP F +I Sbjct: 430 SDRPAFAEI 438
>P41243:MATK_RAT Megakaryocyte-associated tyrosine-protein kinase - Rattus norvegicus| (Rat) Length = 467 Score = 134 bits (338), Expect = 1e-30 Identities = 81/248 (32%), Positives = 133/248 (53%), Gaps = 1/248 (0%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGREVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSF 810 + G V G Y G++VA+K + + D A + F E A++ +L+H N+V Sbjct: 199 QIGEGEFGAVLQGEYLGQKVAVKNI----KCDVTA----QAFLDETAVMTKLQHRNLVRL 250 Query: 811 VAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGILH 990 + ++ I+ E+++ G+L +L + V +LQ AL +A GM YL S+ ++H Sbjct: 251 LGVILHHGLY-IVMEHVSKGNLVNFLRTRGRALVSTSQLLQFALHVAEGMEYLESKKLVH 309 Query: 991 RDLKSENVLLGEDMSVKVADFGISCLESQCGSGKGFTGTYRWMAPEMIKEKNHTRKVDVY 1170 RDL + N+L+ ED+ KV+DFG++ E + G +W APE +K + K DV+ Sbjct: 310 RDLAARNILVSEDLVAKVSDFGLAKAELRKGLDSSRL-PVKWTAPEALKNGRFSSKSDVW 368 Query: 1171 SFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATNPDK 1347 SFG++LWE+ + P+ +M+ ++ + AV K R P SCP + L+ CW P + Sbjct: 369 SFGVLLWEVFSYGRAPYPKMSLKEVSEAVE-KGYRMEPPDSCPGPVHTLMGSCWEAEPSR 427 Query: 1348 RPQFDDIV 1371 RP F IV Sbjct: 428 RPPFRKIV 435
>P54757:EPHA5_RAT Ephrin type-A receptor 5 precursor - Rattus norvegicus (Rat)| Length = 1005 Score = 134 bits (338), Expect = 1e-30 Identities = 82/217 (37%), Positives = 117/217 (53%), Gaps = 5/217 (2%) Frame = +1 Query: 748 RQFASEVALLLRLRHHNIVSFVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLV 927 R F SE +++ + H NI+ K I+TEYM GSL +L + + IQLV Sbjct: 721 RDFLSEASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLV 780 Query: 928 LQLALDIARGMSYLHSQGILHRDLKSENVLLGEDMSVKVADFGIS-CLESQ---CGSGKG 1095 L IA GM YL G +HRDL + N+L+ ++ KV+DFG+S LE + +G Sbjct: 781 GMLR-GIAAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRG 839 Query: 1096 FTGTYRWMAPEMIKEKNHTRKVDVYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNAR 1272 RW APE I + T DV+S+GIV+WE+++ P+ EMT Q I + R Sbjct: 840 GKIPIRWTAPEAIAFRKFTSASDVWSYGIVMWEVVSYGERPYWEMT-NQDVIKAVEEGYR 898 Query: 1273 PPLPASCPVAMSHLISQCWATNPDKRPQFDDIVVVLE 1383 P P CP A+ L+ CW + + RP+FDDIV +L+ Sbjct: 899 LPSPMDCPAALYQLMLDCWQKDRNSRPKFDDIVNMLD 935
>Q02977:YRK_CHICK Proto-oncogene tyrosine-protein kinase Yrk - Gallus gallus (Chicken)| Length = 536 Score = 134 bits (337), Expect = 1e-30 Identities = 80/262 (30%), Positives = 142/262 (54%), Gaps = 4/262 (1%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGR-EVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVS 807 + +G+ V+ G +NG +VA+K + + ++ E F E ++ RLRH +V Sbjct: 275 KLGNGQFGEVWMGTWNGTTKVAVKTL----KPGTMSPEA---FLEEAQIMKRLRHDKLVQ 327 Query: 808 FVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGIL 987 A + P++ I+TE+M+ GSL +L + + + ++ +A IA GM+Y+ + Sbjct: 328 LYAVVSEEPIY-IVTEFMSQGSLLDFLKDGDGRYLKLPQLVDMAAQIAAGMAYIERMNYI 386 Query: 988 HRDLKSENVLLGEDMSVKVADFGISCL--ESQCGSGKGFTGTYRWMAPEMIKEKNHTRKV 1161 HRDL++ N+L+G+++ K+ADFG++ L +++ + +G +W APE T K Sbjct: 387 HRDLRAANILVGDNLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALFGKFTIKS 446 Query: 1162 DVYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATN 1338 DV+SFGI+L E++T VP+ M + V + R P CP ++ ++ QCW Sbjct: 447 DVWSFGILLTELVTKGRVPYPGMNNREVLEQVE-RGYRMQCPGGCPPSLHDVMVQCWKRE 505 Query: 1339 PDKRPQFDDIVVVLEGYKEALD 1404 P++RP F+ + LE Y A + Sbjct: 506 PEERPTFEYLQSFLEDYFTATE 527
>P27447:YES_XIPHE Tyrosine-protein kinase Yes - Xiphophorus helleri| Length = 544 Score = 134 bits (337), Expect = 1e-30 Identities = 82/262 (31%), Positives = 140/262 (53%), Gaps = 4/262 (1%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGR-EVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVS 807 R G V+ G +NG +VAIK + + ++ E F E ++ +LRH +V Sbjct: 283 RLGQGCFGEVWMGTWNGTTKVAIKTL----KPGTMSPEA---FLEEAQIMKKLRHDKLVP 335 Query: 808 FVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGIL 987 A + P++ I+TE+M GSL +L + + + + ++ +A IA GM+++ + Sbjct: 336 LYAVVSEEPIY-IVTEFMGKGSLLDFLKEGDGKHLKLPQLVDMASQIADGMAFIERMNYI 394 Query: 988 HRDLKSENVLLGEDMSVKVADFGISCL--ESQCGSGKGFTGTYRWMAPEMIKEKNHTRKV 1161 HRDL++ N+L+ +++ K+ADFG++ L +++ + +G +W APE T K Sbjct: 395 HRDLRAANILVADNLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKS 454 Query: 1162 DVYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATN 1338 DV+SFGI+L E++T VP+ M + V + R P P CP ++ ++ QCW Sbjct: 455 DVWSFGILLTELVTKGRVPYPGMVNREVLEQVD-RGYRMPCPQGCPESLHEMMRQCWKKE 513 Query: 1339 PDKRPQFDDIVVVLEGYKEALD 1404 PD+RP F+ I LE Y A + Sbjct: 514 PDERPTFEYIQSFLEDYFTATE 535
>P05480:SRC_MOUSE Neuronal proto-oncogene tyrosine-protein kinase Src - Mus musculus| (Mouse) Length = 541 Score = 134 bits (337), Expect = 1e-30 Identities = 83/257 (32%), Positives = 136/257 (52%), Gaps = 4/257 (1%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGR-EVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVS 807 + G V+ G +NG VAIK + + ++ E F E ++ +LRH +V Sbjct: 280 KLGQGCFGEVWMGTWNGTTRVAIKTL----KPGTMSPEA---FLQEAQVMKKLRHEKLVQ 332 Query: 808 FVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGIL 987 A + P++ I+TEYM GSL +L + + + ++ ++ IA GM+Y+ + Sbjct: 333 LYAVVSEEPIY-IVTEYMNKGSLLDFLKGETGKYLRLPQLVDMSAQIASGMAYVERMNYV 391 Query: 988 HRDLKSENVLLGEDMSVKVADFGISCL--ESQCGSGKGFTGTYRWMAPEMIKEKNHTRKV 1161 HRDL++ N+L+GE++ KVADFG++ L +++ + +G +W APE T K Sbjct: 392 HRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKS 451 Query: 1162 DVYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATN 1338 DV+SFGI+L E+ T VP+ M + V + R P P CP ++ L+ QCW Sbjct: 452 DVWSFGILLTELTTKGRVPYPGMVNREVLDQVE-RGYRMPCPPECPESLHDLMCQCWRKE 510 Query: 1339 PDKRPQFDDIVVVLEGY 1389 P++RP F+ + LE Y Sbjct: 511 PEERPTFEYLQAFLEDY 527
>P08631:HCK_HUMAN Tyrosine-protein kinase HCK - Homo sapiens (Human)| Length = 526 Score = 134 bits (337), Expect = 1e-30 Identities = 79/263 (30%), Positives = 146/263 (55%), Gaps = 4/263 (1%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGR-EVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVS 807 + +G+ V+ YN +VA+K + + +++ E F +E ++ L+H +V Sbjct: 267 KLGAGQFGEVWMATYNKHTKVAVKTM----KPGSMSVEA---FLAEANVMKTLQHDKLVK 319 Query: 808 FVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGIL 987 A K P++ IITE+MA GSL +L E P+ ++ + IA GM+++ + + Sbjct: 320 LHAVVTKEPIY-IITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYI 378 Query: 988 HRDLKSENVLLGEDMSVKVADFGISCL--ESQCGSGKGFTGTYRWMAPEMIKEKNHTRKV 1161 HRDL++ N+L+ + K+ADFG++ + +++ + +G +W APE I + T K Sbjct: 379 HRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGSFTIKS 438 Query: 1162 DVYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATN 1338 DV+SFGI+L EI+T +P+ M+ + A+ + R P P +CP + +++ +CW Sbjct: 439 DVWSFGILLMEIVTYGRIPYPGMSNPEVIRALE-RGYRMPRPENCPEELYNIMMRCWKNR 497 Query: 1339 PDKRPQFDDIVVVLEGYKEALDN 1407 P++RP F+ I VL+ + A ++ Sbjct: 498 PEERPTFEYIQSVLDDFYTATES 520
>Q9WUD9:SRC_RAT Proto-oncogene tyrosine-protein kinase Src - Rattus norvegicus (Rat)| Length = 536 Score = 134 bits (336), Expect = 2e-30 Identities = 83/257 (32%), Positives = 136/257 (52%), Gaps = 4/257 (1%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGR-EVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVS 807 + G V+ G +NG VAIK + + ++ E F E ++ +LRH +V Sbjct: 275 KLGQGCFGEVWMGTWNGTTRVAIKTL----KPGTMSPEA---FLQEAQVMKKLRHEKLVQ 327 Query: 808 FVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGIL 987 A + P++ I+TEYM GSL +L + + + ++ ++ IA GM+Y+ + Sbjct: 328 LYAVVSEEPIY-IVTEYMNKGSLLDFLKGETGKYLRLPQLVDMSAQIASGMAYVDRMNYV 386 Query: 988 HRDLKSENVLLGEDMSVKVADFGISCL--ESQCGSGKGFTGTYRWMAPEMIKEKNHTRKV 1161 HRDL++ N+L+GE++ KVADFG++ L +++ + +G +W APE T K Sbjct: 387 HRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKS 446 Query: 1162 DVYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATN 1338 DV+SFGI+L E+ T VP+ M + V + R P P CP ++ L+ QCW Sbjct: 447 DVWSFGILLTELTTKGRVPYPGMVNREVLDQVE-RGYRMPCPPECPESLHDLMCQCWRKE 505 Query: 1339 PDKRPQFDDIVVVLEGY 1389 P++RP F+ + LE Y Sbjct: 506 PEERPTFEYLQAFLEDY 522
>Q03145:EPHA2_MOUSE Ephrin type-A receptor 2 precursor - Mus musculus (Mouse)| Length = 977 Score = 134 bits (336), Expect = 2e-30 Identities = 81/223 (36%), Positives = 121/223 (54%), Gaps = 5/223 (2%) Frame = +1 Query: 754 FASEVALLLRLRHHNIVSFVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQ 933 F SE +++ + HHNI+ K IITEYM G+L K+L +++ +QLV Sbjct: 661 FLSEASIMGQFSHHNIIPLEGVVSKYKPMMIITEYMENGALDKFLREKDGEFSVLQLVGM 720 Query: 934 LALDIARGMSYLHSQGILHRDLKSENVLLGEDMSVKVADFGIS-CLESQCGSGKGFTG-- 1104 L IA GM YL + +HRDL + N+L+ ++ KV+DFG+S LE + +G Sbjct: 721 LR-GIASGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGK 779 Query: 1105 -TYRWMAPEMIKEKNHTRKVDVYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPP 1278 RW APE I + T DV+S+GIV+WE++T P+ E++ + A+ R P Sbjct: 780 IPIRWTAPEAISYRKFTSASDVWSYGIVMWEVMTYGERPYWELSNHEVMKAIN-DGFRLP 838 Query: 1279 LPASCPVAMSHLISQCWATNPDKRPQFDDIVVVLEGYKEALDN 1407 P CP A+ L+ QCW +RP+F DIV +L+ A D+ Sbjct: 839 TPMDCPSAIYQLMMQCWQQERSRRPKFADIVSILDKLIRAPDS 881
>P08103:HCK_MOUSE Tyrosine-protein kinase HCK - Mus musculus (Mouse)| Length = 524 Score = 133 bits (334), Expect = 3e-30 Identities = 78/263 (29%), Positives = 146/263 (55%), Gaps = 4/263 (1%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGR-EVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVS 807 + +G+ V+ YN +VA+K + + +++ E F +E L+ L+H +V Sbjct: 265 KLGAGQFGEVWMATYNKHTKVAVKTM----KPGSMSVEA---FLAEANLMKSLQHDKLVK 317 Query: 808 FVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGIL 987 A + P+F I+TE+MA GSL +L +E P+ ++ + I+ GM+++ + + Sbjct: 318 LHAVVSQEPIF-IVTEFMAKGSLLDFLKSEEGSKQPLPKLIDFSAQISEGMAFIEQRNYI 376 Query: 988 HRDLKSENVLLGEDMSVKVADFGISCL--ESQCGSGKGFTGTYRWMAPEMIKEKNHTRKV 1161 HRDL++ N+L+ + K+ADFG++ + +++ + +G +W APE I + T K Sbjct: 377 HRDLRAANILVSASLVCKIADFGLARIIEDNEYTAREGAKFPIKWTAPEAINFGSFTIKS 436 Query: 1162 DVYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATN 1338 DV+SFGI+L EI+T +P+ M+ + A+ R P P +CP + +++ +CW Sbjct: 437 DVWSFGILLMEIVTYGRIPYPGMSNPEVIRALE-HGYRMPRPDNCPEELYNIMIRCWKNR 495 Query: 1339 PDKRPQFDDIVVVLEGYKEALDN 1407 P++RP F+ I VL+ + A ++ Sbjct: 496 PEERPTFEYIQSVLDDFYTATES 518
>Q61UC4:KRAF1_CAEBR Raf homolog serine/threonine-protein kinase - Caenorhabditis briggsae| Length = 811 Score = 132 bits (333), Expect = 4e-30 Identities = 84/261 (32%), Positives = 146/261 (55%), Gaps = 14/261 (5%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGREVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSF 810 + SG VY G + G VAIK ++ + A F +EVA+L + RH N++ F Sbjct: 484 KVGSGSFGTVYRGEFFGT-VAIKKLNVVDPTPSQMAA----FKNEVAVLKKTRHLNVLLF 538 Query: 811 VAACKKPPVFCIITEYMAGGSLRKYLHQQEPH-SVPIQLVLQLALDIARGMSYLHSQGIL 987 + ++P + IIT++ G SL +++H QEP + V+ + ++ GM+YLHS+ I+ Sbjct: 539 MGWVREPEI-AIITQWCEGSSLYRHIHVQEPRVEFEMSAVIDILKQVSLGMNYLHSKNII 597 Query: 988 HRDLKSENVLLGEDMS-VKVADFGISCLESQCGSGKGF-----TGTYRWMAPEMIK---E 1140 HRDLK+ N+ L +DMS VK+ DFG++ ++++ G TG+ WMAPE+I+ + Sbjct: 598 HRDLKTNNIFLMDDMSTVKIGDFGLATVKTKWTVNGGQQQQQPTGSILWMAPEVIRMQDD 657 Query: 1141 KNHTRKVDVYSFGIVLWEILTALVPFSEMTPEQAAIAVA----LKNARPPLPASCPVAMS 1308 +T + DVYSFG+ ++EIL++ +P+S + + + LK R + P ++ Sbjct: 658 NPYTPQSDVYSFGVCMYEILSSHLPYSNINNRDQILFMVGRGYLKPDRSKIRTDTPKSLM 717 Query: 1309 HLISQCWATNPDKRPQFDDIV 1371 L C + ++RP F +++ Sbjct: 718 KLYDNCIMFDRNERPVFGEVL 738
>P42689:SRK3_SPOLA Tyrosine-protein kinase SRK3 - Spongilla lacustris (Freshwater| sponge) Length = 334 Score = 132 bits (332), Expect = 5e-30 Identities = 78/256 (30%), Positives = 125/256 (48%), Gaps = 3/256 (1%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGREVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSF 810 + G V+ G +NG +P + + F E ++ ++ H N++ Sbjct: 71 KLGQGNFGEVWAGVWNGTTAVAVKTLKPDTMEV------KDFVQEAQVMKKIHHPNLLQL 124 Query: 811 VAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGILH 990 A C I+TE M GS+ +YL E ++ + ++ ++ IA GM+YL + +H Sbjct: 125 YAVCTIGEPIYIVTELMKYGSMLEYLKHGEGKNITLHQMVDMSAQIASGMTYLEAHSYIH 184 Query: 991 RDLKSENVLLGEDMSVKVADFGISCL--ESQCGSGKGFTGTYRWMAPEMIKEKNHTRKVD 1164 RDL + N+L+GE KVADFG++ + E +G +W APE T K D Sbjct: 185 RDLAARNILVGEGNVCKVADFGLARVIKEDIYNPREGTKFPIKWTAPEAALYNRFTIKSD 244 Query: 1165 VYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATNP 1341 V+SFG+++ EI+T +P+ MT Q AV + R P P CP + ++ CW P Sbjct: 245 VWSFGVLISEIVTHGRMPYPGMTNRQVLEAVD-RGYRMPCPEGCPDPLYKIMLSCWKHEP 303 Query: 1342 DKRPQFDDIVVVLEGY 1389 D RP F+ + +LE Y Sbjct: 304 DDRPTFESLKNLLEDY 319
>P41242:MATK_MOUSE Megakaryocyte-associated tyrosine-protein kinase - Mus musculus| (Mouse) Length = 505 Score = 132 bits (332), Expect = 5e-30 Identities = 81/251 (32%), Positives = 134/251 (53%), Gaps = 4/251 (1%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGREVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSF 810 + G V G Y G++VA+K + + D A + F E A++ +L+H N+V Sbjct: 238 QIGEGEFGAVLQGEYLGQKVAVKNI----KCDVTA----QAFLDETAVMTKLQHRNLVRL 289 Query: 811 VAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGILH 990 + ++ I+ E+++ G+L +L + V +LQ AL +A GM YL S+ ++H Sbjct: 290 LGVILHHGLY-IVMEHVSKGNLVNFLRTRGRALVSTSQLLQFALHVAEGMEYLESKKLVH 348 Query: 991 RDLKSENVLLGEDMSVKVADFGISCLESQCGSGKGFTGT---YRWMAPEMIKEKNHTRKV 1161 RDL + N+L+ ED+ KV+DFG++ E KG + +W APE +K + K Sbjct: 349 RDLAARNILVSEDLVAKVSDFGLAKAER-----KGLDSSRLPVKWTAPEALKNGRFSSKS 403 Query: 1162 DVYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATN 1338 DV+SFG++LWE+ + P+ +M+ ++ + AV K R P CP ++ L+ CW Sbjct: 404 DVWSFGVLLWEVFSYGRAPYPKMSLKEVSEAVE-KGYRMEPPDGCPGSVHTLMGSCWEAE 462 Query: 1339 PDKRPQFDDIV 1371 P +RP F IV Sbjct: 463 PARRPPFRKIV 473
>P50545:HCK_RAT Tyrosine-protein kinase HCK - Rattus norvegicus (Rat)| Length = 524 Score = 132 bits (332), Expect = 5e-30 Identities = 78/263 (29%), Positives = 145/263 (55%), Gaps = 4/263 (1%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGR-EVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVS 807 + +G+ V+ YN +VA+K + + +++ E F +E L+ L+H +V Sbjct: 265 KLGAGQFGEVWMATYNKHTKVAVKTM----KPGSMSVEA---FLAEANLMKTLQHDKLVK 317 Query: 808 FVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGIL 987 A + P+F I+TE+MA GSL +L +E P+ ++ + I+ GM+++ + + Sbjct: 318 LHAVVSQEPIF-IVTEFMAKGSLLDFLKSEEGSKQPLPKLIDFSAQISEGMAFIEQRNYI 376 Query: 988 HRDLKSENVLLGEDMSVKVADFGISCL--ESQCGSGKGFTGTYRWMAPEMIKEKNHTRKV 1161 HRDL++ N+L+ + K+ADFG++ + +++ + +G +W APE I + T K Sbjct: 377 HRDLRAANILVSASLVCKIADFGLARIIEDNEYTAREGAKFPIKWTAPEAINFGSFTIKS 436 Query: 1162 DVYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATN 1338 DV+SFGI+L EI+T +P+ M+ + A+ R P P +CP + ++ +CW Sbjct: 437 DVWSFGILLMEIVTYGRIPYPGMSNPEVIRALE-HGYRMPRPDNCPEELYSIMIRCWKNR 495 Query: 1339 PDKRPQFDDIVVVLEGYKEALDN 1407 P++RP F+ I VL+ + A ++ Sbjct: 496 PEERPTFEYIQSVLDDFYTATES 518
>P54755:EPHA5_CHICK Ephrin type-A receptor 5 precursor - Gallus gallus (Chicken)| Length = 1013 Score = 132 bits (332), Expect = 5e-30 Identities = 80/217 (36%), Positives = 116/217 (53%), Gaps = 5/217 (2%) Frame = +1 Query: 748 RQFASEVALLLRLRHHNIVSFVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLV 927 R F E +++ + H NI+ K I+TEYM GSL +L + + IQLV Sbjct: 695 RDFLGEASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLV 754 Query: 928 LQLALDIARGMSYLHSQGILHRDLKSENVLLGEDMSVKVADFGIS-CLESQ---CGSGKG 1095 L IA GM YL G +HRDL + N+L+ ++ KV+DFG+S LE + +G Sbjct: 755 GMLR-GIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRG 813 Query: 1096 FTGTYRWMAPEMIKEKNHTRKVDVYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNAR 1272 RW APE I + T DV+S+GIV+WE+++ P+ EMT Q I + R Sbjct: 814 GKIPIRWTAPEAIAFRKFTSASDVWSYGIVMWEVMSYGERPYWEMT-NQDVIKAVEEGYR 872 Query: 1273 PPLPASCPVAMSHLISQCWATNPDKRPQFDDIVVVLE 1383 P P CP A+ L+ CW + + RP+FD+IV +L+ Sbjct: 873 LPSPMDCPAALYQLMLDCWQKDRNSRPKFDEIVSMLD 909
>P29317:EPHA2_HUMAN Ephrin type-A receptor 2 precursor - Homo sapiens (Human)| Length = 976 Score = 132 bits (332), Expect = 5e-30 Identities = 81/223 (36%), Positives = 119/223 (53%), Gaps = 5/223 (2%) Frame = +1 Query: 754 FASEVALLLRLRHHNIVSFVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQ 933 F E ++ + HHNI+ K IITEYM G+L K+L +++ +QLV Sbjct: 660 FLGEAGIMGQFSHHNIIRLEGVISKYKPMMIITEYMENGALDKFLREKDGEFSVLQLVGM 719 Query: 934 LALDIARGMSYLHSQGILHRDLKSENVLLGEDMSVKVADFGIS-CLESQCGSGKGFTG-- 1104 L IA GM YL + +HRDL + N+L+ ++ KV+DFG+S LE + +G Sbjct: 720 LR-GIAAGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGK 778 Query: 1105 -TYRWMAPEMIKEKNHTRKVDVYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPP 1278 RW APE I + T DV+SFGIV+WE++T P+ E++ + A+ R P Sbjct: 779 IPIRWTAPEAISYRKFTSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAIN-DGFRLP 837 Query: 1279 LPASCPVAMSHLISQCWATNPDKRPQFDDIVVVLEGYKEALDN 1407 P CP A+ L+ QCW +RP+F DIV +L+ A D+ Sbjct: 838 TPMDCPSAIYQLMMQCWQQERARRPKFADIVSILDKLIRAPDS 880
>Q60629:EPHA5_MOUSE Ephrin type-A receptor 5 precursor - Mus musculus (Mouse)| Length = 877 Score = 131 bits (330), Expect = 8e-30 Identities = 80/217 (36%), Positives = 116/217 (53%), Gaps = 5/217 (2%) Frame = +1 Query: 748 RQFASEVALLLRLRHHNIVSFVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLV 927 R F E +++ + H NI+ K I+TEYM GSL +L + + IQLV Sbjct: 558 RDFLGEASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLV 617 Query: 928 LQLALDIARGMSYLHSQGILHRDLKSENVLLGEDMSVKVADFGIS-CLESQ---CGSGKG 1095 L IA GM YL G +HRDL + N+L+ ++ KV+DFG+S LE + +G Sbjct: 618 GMLR-GIAAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRG 676 Query: 1096 FTGTYRWMAPEMIKEKNHTRKVDVYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNAR 1272 RW APE I + T DV+S+GIV+WE+++ P+ EMT Q I + R Sbjct: 677 GKIPIRWTAPEAIAFRKFTSASDVWSYGIVMWEVVSYGERPYWEMT-NQDVIKAVEEGYR 735 Query: 1273 PPLPASCPVAMSHLISQCWATNPDKRPQFDDIVVVLE 1383 P P CP A+ L+ CW + + RP+FD+IV +L+ Sbjct: 736 LPSPMDCPAALYQLMLDCWQKDRNSRPKFDEIVNMLD 772
>P41240:CSK_HUMAN Tyrosine-protein kinase CSK - Homo sapiens (Human)| Length = 450 Score = 131 bits (330), Expect = 8e-30 Identities = 93/280 (33%), Positives = 140/280 (50%), Gaps = 5/280 (1%) Frame = +1 Query: 568 QDPGRRRG-ALERRPLKARDPGRFASGRHSRVYFGRYNGREVAIKMVSQPHEDDALAAEL 744 QD R G AL + LK G V G Y G +VA+K + ++DA A Sbjct: 180 QDEFYRSGWALNMKELKLLQT--IGKGEFGDVMLGDYRGNKVAVKCI----KNDATA--- 230 Query: 745 ERQFASEVALLLRLRHHNIVSFVAAC-KKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQ 921 + F +E +++ +LRH N+V + ++ I+TEYMA GSL YL + + Sbjct: 231 -QAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGD 289 Query: 922 LVLQLALDIARGMSYLHSQGILHRDLKSENVLLGEDMSVKVADFGISCLESQCGSGKGFT 1101 +L+ +LD+ M YL +HRDL + NVL+ ED KV+DFG+ ++ S T Sbjct: 290 CLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGL----TKEASSTQDT 345 Query: 1102 G--TYRWMAPEMIKEKNHTRKVDVYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNAR 1272 G +W APE ++EK + K DV+SFGI+LWEI + VP+ + P + + K + Sbjct: 346 GKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRI-PLKDVVPRVEKGYK 404 Query: 1273 PPLPASCPVAMSHLISQCWATNPDKRPQFDDIVVVLEGYK 1392 P CP A+ ++ CW + RP F + LE K Sbjct: 405 MDAPDGCPPAVYEVMKNCWHLDAAMRPSFLQLREQLEHIK 444
>Q0VBZ0:CSK_BOVIN Tyrosine-protein kinase CSK - Bos taurus (Bovine)| Length = 450 Score = 131 bits (330), Expect = 8e-30 Identities = 93/280 (33%), Positives = 140/280 (50%), Gaps = 5/280 (1%) Frame = +1 Query: 568 QDPGRRRG-ALERRPLKARDPGRFASGRHSRVYFGRYNGREVAIKMVSQPHEDDALAAEL 744 QD R G AL + LK G V G Y G +VA+K + ++DA A Sbjct: 180 QDEFFRSGWALNMKDLKLLQT--IGKGEFGDVMLGDYRGNKVAVKCI----KNDATA--- 230 Query: 745 ERQFASEVALLLRLRHHNIVSFVAAC-KKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQ 921 + F +E +++ +LRH N+V + ++ I+TEYMA GSL YL + + Sbjct: 231 -QAFLAEASVMTQLRHSNLVQLLGVIVEEKSGLYIVTEYMAKGSLVDYLRSRGRSVLGGD 289 Query: 922 LVLQLALDIARGMSYLHSQGILHRDLKSENVLLGEDMSVKVADFGISCLESQCGSGKGFT 1101 +L+ +LD+ M YL +HRDL + NVL+ ED KV+DFG+ ++ S T Sbjct: 290 CLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGL----TKEASSTQDT 345 Query: 1102 G--TYRWMAPEMIKEKNHTRKVDVYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNAR 1272 G +W APE ++EK + K DV+SFGI+LWEI + VP+ + P + + K + Sbjct: 346 GKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRI-PLKDVVPRVEKGYK 404 Query: 1273 PPLPASCPVAMSHLISQCWATNPDKRPQFDDIVVVLEGYK 1392 P CP A+ ++ CW + RP F + LE K Sbjct: 405 MDAPDGCPPAVYEVMKNCWHLDAATRPSFLQLREQLERIK 444
>P16277:BLK_MOUSE Tyrosine-protein kinase BLK - Mus musculus (Mouse)| Length = 499 Score = 131 bits (330), Expect = 8e-30 Identities = 83/263 (31%), Positives = 143/263 (54%), Gaps = 5/263 (1%) Frame = +1 Query: 631 RFASGRHSRVYFGRY-NGREVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVS 807 + SG+ V+ G Y N +VAIK + ++ ++ E F E ++ L+H +V Sbjct: 240 KLGSGQFGEVWMGYYKNNMKVAIKTL----KEGTMSPEA---FLGEANVMKTLQHERLVR 292 Query: 808 FVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGIL 987 A + P++ I+TEYMA G L +L E + + ++ ++ +A GM+Y+ + Sbjct: 293 LYAVVTREPIY-IVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQVAEGMAYIERMNSI 351 Query: 988 HRDLKSENVLLGEDMSVKVADFGIS-CLESQCGSGKGFTGTYRWMAPEMIKEKNHTRKVD 1164 HRDL++ N+L+ E + K+ADFG++ ++S+ + +G +W APE I T K D Sbjct: 352 HRDLRAANILVSETLCCKIADFGLARIIDSEYTAQEGAKFPIKWTAPEAIHFGVFTIKAD 411 Query: 1165 VYSFGIVLWEILT-ALVPFSEMT-PEQAAIAVALKNARPPLPASCPVAM-SHLISQCWAT 1335 V+SFG++L I+T VP+ M+ PE I R P P +CP + + +I++CW Sbjct: 412 VWSFGVLLMVIVTYGRVPYPGMSNPE--VIRSLEHGYRMPCPETCPPELYNDIITECWRG 469 Query: 1336 NPDKRPQFDDIVVVLEGYKEALD 1404 P++RP F+ + VLE + A + Sbjct: 470 RPEERPTFEFLQSVLEDFYTATE 492
>Q01389:BCK1_YEAST Serine/threonine-protein kinase BCK1/SLK1/SSP31 - Saccharomyces| cerevisiae (Baker's yeast) Length = 1478 Score = 131 bits (330), Expect = 8e-30 Identities = 78/241 (32%), Positives = 130/241 (53%), Gaps = 10/241 (4%) Frame = +1 Query: 679 GREVAIKMVSQPH---EDDALAAELERQFASEVALLLRLRHHNIVSFVAACKKPPVFCII 849 G +A+K V P +++A+ + +E SEV+ L L H NIV ++ K ++ + Sbjct: 1198 GEMMAVKQVEVPKYSSQNEAILSTVEA-LRSEVSTLKDLDHLNIVQYLGFENKNNIYSLF 1256 Query: 850 TEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGILHRDLKSENVLLGED 1029 EY+AGGS+ + P L+ L + +G++YLHS+GILHRD+K++N+LL +D Sbjct: 1257 LEYVAGGSVGSLIRMYGRFDEP--LIKHLTTQVLKGLAYLHSKGILHRDMKADNLLLDQD 1314 Query: 1030 MSVKVADFGISCLESQCGSGKGFT--GTYRWMAPEMIKEK-NHTRKVDVYSFGIVLWEIL 1200 K++DFGIS S T GT WMAPEM+ K ++ KVD++S G ++ E+ Sbjct: 1315 GICKISDFGISRKSKDIYSNSDMTMRGTVFWMAPEMVDTKQGYSAKVDIWSLGCIVLEMF 1374 Query: 1201 TALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHL----ISQCWATNPDKRPQFDDI 1368 P+S + A + + PP+P +S + + C+ NP+KRP +++ Sbjct: 1375 AGKRPWSNLEVVAAMFKIGKSKSAPPIPEDTLPLISQIGRNFLDACFEINPEKRPTANEL 1434 Query: 1369 V 1371 + Sbjct: 1435 L 1435
>Q4JIM5:ABL2_MOUSE Tyrosine-protein kinase ABL2 - Mus musculus (Mouse)| Length = 1182 Score = 131 bits (330), Expect = 8e-30 Identities = 77/246 (31%), Positives = 126/246 (51%), Gaps = 3/246 (1%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGREVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSF 810 + G++ VY G + ++ ++ + + ++D + E +F E A++ ++H N+V Sbjct: 293 KLGGGQYGEVYVGVW--KKYSLTVAVKTFKEDTMEVE---EFLKEAAVMKEIKHPNLVQL 347 Query: 811 VAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGILH 990 + C P F I+TEYM G+L YL + V ++L +A I+ M YL + +H Sbjct: 348 LGVCTLEPPFYIVTEYMPYGNLLDYLRECSREEVTAVVLLYMATQISSAMEYLEKKNFIH 407 Query: 991 RDLKSENVLLGEDMSVKVADFGISCLES--QCGSGKGFTGTYRWMAPEMIKEKNHTRKVD 1164 RDL + N L+GE+ VKVADFG+S L + + G +W APE + + K D Sbjct: 408 RDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSD 467 Query: 1165 VYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATNP 1341 V++FG++LWEI T + P+ + Q + K R P CP + L+ CW +P Sbjct: 468 VWAFGVLLWEIATYGMSPYPGIDLSQ-VYDLLEKGYRMEQPEGCPPKVYELMRACWKWSP 526 Query: 1342 DKRPQF 1359 RP F Sbjct: 527 ADRPSF 532
>Q62270:SRMS_MOUSE Tyrosine-protein kinase Srms - Mus musculus (Mouse)| Length = 496 Score = 131 bits (329), Expect = 1e-29 Identities = 81/247 (32%), Positives = 130/247 (52%), Gaps = 4/247 (1%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGR-EVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVS 807 + G V+ G + G VA+K++ D A+L + E+ L LRH ++ Sbjct: 239 KLGEGFFGEVWEGLWLGSIPVAVKVIKSA---DMKLADLTK----EIEALKSLRHERLIR 291 Query: 808 FVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGIL 987 A C I+TE M G+L+ YL E ++ + +L A +A GMSYL + ++ Sbjct: 292 LHAICSLGEPVYIVTELMGKGNLQVYLGSSEGKALSLPHLLGFACQVAEGMSYLEERRVV 351 Query: 988 HRDLKSENVLLGEDMSVKVADFGISCL--ESQCGSGKGFTGTYRWMAPEMIKEKNHTRKV 1161 HRDL + NVL+G+D++ KVADFG++ L + G +W APE + ++K Sbjct: 352 HRDLAARNVLVGDDLTCKVADFGLARLLKDDVYSPSSGSKIPVKWTAPEAANYRVFSQKS 411 Query: 1162 DVYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATN 1338 DV+SFGI+L+E+ T P+ MT + ++ + R P PA CP + L+ +CW + Sbjct: 412 DVWSFGILLYEVFTYGQCPYEGMTNHETLQQIS-RGYRLPRPAVCPAEVYVLMVECWKGS 470 Query: 1339 PDKRPQF 1359 P++RP F Sbjct: 471 PEERPTF 477
>Q9V9J3:SRC42_DROME Tyrosine-protein kinase Src42A - Drosophila melanogaster (Fruit fly)| Length = 517 Score = 131 bits (329), Expect = 1e-29 Identities = 86/266 (32%), Positives = 136/266 (51%), Gaps = 6/266 (2%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGRE-VAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVS 807 + SG+ V+ G +N VAIK + D + F +E ++ +LRH ++ Sbjct: 253 KLGSGQFGDVWEGLWNNTTPVAIKTLKSGTMDP-------KDFLAEAQIMKKLRHTKLIQ 305 Query: 808 FVAACKKPPVFCIITEYMAGGSLRKYLHQ--QEPHSVPIQLVLQLALDIARGMSYLHSQG 981 A C IITE M GSL +YL + S+ +Q ++ +A IA GM+YL SQ Sbjct: 306 LYAVCTVEEPIYIITELMKHGSLLEYLQAIAGKGRSLKMQTLIDMAAQIAAGMAYLESQN 365 Query: 982 ILHRDLKSENVLLGEDMSVKVADFGISCL--ESQCGSGKGFTGTYRWMAPEMIKEKNHTR 1155 +HRDL + NVL+G+ VK+ADFG++ L E + + G +W APE + Sbjct: 366 YIHRDLAARNVLVGDGNIVKIADFGLARLIKEDEYEARVGARFPIKWTAPEAANYSKFSI 425 Query: 1156 KVDVYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWA 1332 K DV+SFGI+L E++T +P+ MT + V R P P +C + ++ +CW Sbjct: 426 KSDVWSFGILLTELVTYGRIPYPGMTNAEVLTQVE-HGYRMPQPPNCEPRLYEIMLECWH 484 Query: 1333 TNPDKRPQFDDIVVVLEGYKEALDND 1410 +P +RP F+ + LE + + +D Sbjct: 485 KDPMRRPTFETLQWKLEDFYTSDQSD 510
>P42690:SRK4_SPOLA Tyrosine-protein kinase isoform SRK4 - Spongilla lacustris| (Freshwater sponge) Length = 506 Score = 130 bits (328), Expect = 1e-29 Identities = 83/254 (32%), Positives = 134/254 (52%), Gaps = 4/254 (1%) Frame = +1 Query: 640 SGRHSRVYFGRYNGR-EVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSFVA 816 +G+ V+ G +NG VA+K + + ++ E +F E +++ +LRH ++ A Sbjct: 248 AGQFGEVWEGLWNGTTSVAVKTL----KPGTMSIE---EFLEEASIMKQLRHPKLIQLYA 300 Query: 817 ACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGILHRD 996 C K I+TE M GSL +YL + + S+ + ++ + +A GMSYL Q +HRD Sbjct: 301 VCTKEEPIYIVTELMKHGSLLEYL-RGDGRSLKLPDLVDMCSQVASGMSYLEQQNYIHRD 359 Query: 997 LKSENVLLGEDMSVKVADFGIS-CLESQCGSGK-GFTGTYRWMAPEMIKEKNHTRKVDVY 1170 L + N+L+GE KVADFG++ ++ + K G +W APE T K DV+ Sbjct: 360 LAARNILVGEHKICKVADFGLARVIDEEIYEAKLGAKFPIKWTAPEAAMYSRFTIKSDVW 419 Query: 1171 SFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATNPDK 1347 SFGIVL+E++T P+ MT Q + ++ R P P CP + ++ CW +P Sbjct: 420 SFGIVLYEVITYGRFPYPGMTNAQVLEQIQ-QSYRMPRPMGCPEKLYAIMMDCWREDPAS 478 Query: 1348 RPQFDDIVVVLEGY 1389 RP F+ + LE + Sbjct: 479 RPTFETLSWQLEEF 492
>P00524:SRC_RSVSA Tyrosine-protein kinase transforming protein Src - Avian leukosis| virus RSA (RSV-SRA) (Rous sarcoma virus (strain Schmidt-Ruppin A)) Length = 526 Score = 130 bits (328), Expect = 1e-29 Identities = 81/248 (32%), Positives = 134/248 (54%), Gaps = 4/248 (1%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGR-EVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVS 807 + G V+ G +NG VAIK + + ++ E F E ++ +LRH +V Sbjct: 272 KLGQGCFGEVWMGTWNGTTRVAIKTL----KPGTMSPEA---FLQEAQVMKKLRHEKLVQ 324 Query: 808 FVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGIL 987 A + P++ I+TEYM+ GSL +L + + + ++ +A IA GM+Y+ + Sbjct: 325 LYAVVSEEPIY-IVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERMNYV 383 Query: 988 HRDLKSENVLLGEDMSVKVADFGISCL--ESQCGSGKGFTGTYRWMAPEMIKEKNHTRKV 1161 HRDL++ N+L+GE++ KVADFG++ L +++ + +G +W APE T K Sbjct: 384 HRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKS 443 Query: 1162 DVYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATN 1338 DV+SFGI+L E+ T VP+ M + V + R P P CP ++ L+ QCW + Sbjct: 444 DVWSFGILLTELTTKGRVPYPGMGNGEVLDRVE-RGYRMPCPPECPESLHDLMCQCWRRD 502 Query: 1339 PDKRPQFD 1362 P++RP F+ Sbjct: 503 PEERPTFE 510
>P00525:SRC_AVISR Tyrosine-protein kinase transforming protein Src - Avian sarcoma| virus (strain rASV1441) Length = 526 Score = 130 bits (328), Expect = 1e-29 Identities = 81/248 (32%), Positives = 134/248 (54%), Gaps = 4/248 (1%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGR-EVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVS 807 + G V+ G +NG VAIK + + ++ E F E ++ +LRH +V Sbjct: 272 KLGQGCFGEVWMGTWNGTTRVAIKTL----KPGTMSPEA---FLQEAQVMKKLRHEKLVQ 324 Query: 808 FVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGIL 987 A + P++ I+TEYM+ GSL +L + + + ++ +A IA GM+Y+ + Sbjct: 325 LYAVVSEEPIY-IVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERMNYV 383 Query: 988 HRDLKSENVLLGEDMSVKVADFGISCL--ESQCGSGKGFTGTYRWMAPEMIKEKNHTRKV 1161 HRDL++ N+L+GE++ KVADFG++ L +++ + +G +W APE T K Sbjct: 384 HRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKS 443 Query: 1162 DVYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATN 1338 DV+SFGI+L E+ T VP+ M + V + R P P CP ++ L+ QCW + Sbjct: 444 DVWSFGILLTELTTKGRVPYPGMGNGEVLDRVE-RGYRMPCPPECPESLHDLMCQCWRRD 502 Query: 1339 PDKRPQFD 1362 P++RP F+ Sbjct: 503 PEERPTFE 510
>P83104:M3LK7_DROME Putative mitogen-activated protein kinase kinase kinase 7-like -| Drosophila melanogaster (Fruit fly) Length = 393 Score = 130 bits (328), Expect = 1e-29 Identities = 83/267 (31%), Positives = 136/267 (50%), Gaps = 10/267 (3%) Frame = +1 Query: 640 SGRHSRVYFGRYNGREVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSFVAA 819 +G V + +E+A+K+ D L +++ E+ L + H N++ + Sbjct: 19 AGSGGAVRKATFQNQEIAVKIF------DFLEETIKKNAEREITHLSEIDHENVIRVIGR 72 Query: 820 CKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHS--QGILHR 993 ++ EY+ GSL YL+ + ++ ++ AL A+ ++YLHS + I+HR Sbjct: 73 ASNGKKDYLLMEYLEEGSLHNYLYGDDKWEYTVEQAVRWALQCAKALAYLHSLDRPIVHR 132 Query: 994 DLKSENVLL-GEDMSVKVADFGISCLESQCGSGKGFTGTYRWMAPEMIKEKNHTRKVDVY 1170 D+K +N+LL + +K+ DFG++ + GT R+MAPE IK +T K DVY Sbjct: 133 DIKPQNMLLYNQHEDLKICDFGLAT--DMSNNKTDMQGTLRYMAPEAIKHLKYTAKCDVY 190 Query: 1171 SFGIVLWEILTALVPFS--EMTPEQAAIAVALKNA-RPPLPA---SCPVAMSHLISQCWA 1332 SFGI+LWE++T +P+S E Q AI A+ + + P+ A CP + L+ C Sbjct: 191 SFGIMLWELMTRQLPYSHLENPNSQYAIMKAISSGEKLPMEAVRSDCPEGIKQLMECCMD 250 Query: 1333 TNPDKRPQFDDIVVVL-EGYKEALDND 1410 NP+KRP +I L E Y+ D D Sbjct: 251 INPEKRPSMKEIEKFLGEQYESGTDED 277
>Q07292:KRAF1_CAEEL Raf homolog serine/threonine-protein kinase - Caenorhabditis elegans| Length = 813 Score = 130 bits (328), Expect = 1e-29 Identities = 84/261 (32%), Positives = 146/261 (55%), Gaps = 14/261 (5%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGREVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSF 810 + SG VY G + G VAIK ++ + A F +EVA+L + RH N++ F Sbjct: 486 KVGSGSFGTVYRGEFFGT-VAIKKLNVVDPTPSQMAA----FKNEVAVLKKTRHLNVLLF 540 Query: 811 VAACKKPPVFCIITEYMAGGSLRKYLHQQEPH-SVPIQLVLQLALDIARGMSYLHSQGIL 987 + ++P + IIT++ G SL +++H QEP + ++ + ++ GM+YLHS+ I+ Sbjct: 541 MGWVREPEI-AIITQWCEGSSLYRHIHVQEPRVEFEMGAIIDILKQVSLGMNYLHSKNII 599 Query: 988 HRDLKSENVLLGEDMS-VKVADFGISCLESQCGSGKGF-----TGTYRWMAPEMIK---E 1140 HRDLK+ N+ L +DMS VK+ DFG++ ++++ G TG+ WMAPE+I+ + Sbjct: 600 HRDLKTNNIFLMDDMSTVKIGDFGLATVKTKWTVNGGQQQQQPTGSILWMAPEVIRMQDD 659 Query: 1141 KNHTRKVDVYSFGIVLWEILTALVPFSEMTPEQAAIAVA----LKNARPPLPASCPVAMS 1308 +T + DVYSFGI ++EIL++ +P+S + + + L+ R + P +M Sbjct: 660 NPYTPQSDVYSFGICMYEILSSHLPYSNINNRDQILFMVGRGYLRPDRSKIRHDTPKSML 719 Query: 1309 HLISQCWATNPDKRPQFDDIV 1371 L C + ++RP F +++ Sbjct: 720 KLYDNCIMFDRNERPVFGEVL 740
>P29319:EPHA3_MOUSE Ephrin type-A receptor 3 precursor - Mus musculus (Mouse)| Length = 983 Score = 130 bits (328), Expect = 1e-29 Identities = 77/217 (35%), Positives = 117/217 (53%), Gaps = 5/217 (2%) Frame = +1 Query: 748 RQFASEVALLLRLRHHNIVSFVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLV 927 R F E +++ + H NI+ K I+TEYM GSL +L + + IQLV Sbjct: 665 RDFLGEASIMGQFDHPNIIRLEGVVTKSKPEMIVTEYMENGSLDSFLRKHDAQFTVIQLV 724 Query: 928 LQLALDIARGMSYLHSQGILHRDLKSENVLLGEDMSVKVADFGIS-CLESQ---CGSGKG 1095 L IA GM YL G +HRDL + N+L+ ++ KV+DFG+S LE + +G Sbjct: 725 GMLR-GIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRG 783 Query: 1096 FTGTYRWMAPEMIKEKNHTRKVDVYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNAR 1272 RW +PE + + T DV+S+GIVLWE+++ P+S+M+ + AV + Sbjct: 784 GKIPIRWTSPEAMSYRKFTSASDVWSYGIVLWEVMSYGERPYSQMSNQDVIKAVDERYRL 843 Query: 1273 PPLPASCPVAMSHLISQCWATNPDKRPQFDDIVVVLE 1383 PP P CP A+ L+ CW + + RP+F+ IV +L+ Sbjct: 844 PP-PMDCPAALYQLMLDCWQKDRNNRPKFEQIVSILD 879
>Q1KL86:EPHA2_MACFA Ephrin type-A receptor 2 precursor - Macaca fascicularis (Crab eating| macaque) (Cynomolgus monkey) Length = 976 Score = 130 bits (328), Expect = 1e-29 Identities = 80/223 (35%), Positives = 119/223 (53%), Gaps = 5/223 (2%) Frame = +1 Query: 754 FASEVALLLRLRHHNIVSFVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQ 933 F E ++ + HHNI+ K IITE+M G+L K+L +++ +QLV Sbjct: 660 FLGEAGIMGQFSHHNIIRLEGVISKYKPMMIITEFMENGALDKFLREKDGEFSVLQLVGM 719 Query: 934 LALDIARGMSYLHSQGILHRDLKSENVLLGEDMSVKVADFGIS-CLESQCGSGKGFTG-- 1104 L IA GM YL + +HRDL + N+L+ ++ KV+DFG+S LE + +G Sbjct: 720 LR-GIAAGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGK 778 Query: 1105 -TYRWMAPEMIKEKNHTRKVDVYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPP 1278 RW APE I + T DV+SFGIV+WE++T P+ E++ + A+ R P Sbjct: 779 IPIRWTAPEAISYRKFTSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAIN-DGFRLP 837 Query: 1279 LPASCPVAMSHLISQCWATNPDKRPQFDDIVVVLEGYKEALDN 1407 P CP A+ L+ QCW +RP+F DIV +L+ A D+ Sbjct: 838 TPMDCPSAIYQLMMQCWQQERARRPKFADIVSILDKLIRAPDS 880
>P42684:ABL2_HUMAN Tyrosine-protein kinase ABL2 - Homo sapiens (Human)| Length = 1182 Score = 130 bits (328), Expect = 1e-29 Identities = 77/246 (31%), Positives = 126/246 (51%), Gaps = 3/246 (1%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGREVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSF 810 + G++ VY G + ++ ++ + + ++D + E +F E A++ ++H N+V Sbjct: 293 KLGGGQYGEVYVGVW--KKYSLTVAVKTLKEDTMEVE---EFLKEAAVMKEIKHPNLVQL 347 Query: 811 VAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGILH 990 + C P F I+TEYM G+L YL + V ++L +A I+ M YL + +H Sbjct: 348 LGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIH 407 Query: 991 RDLKSENVLLGEDMSVKVADFGISCLES--QCGSGKGFTGTYRWMAPEMIKEKNHTRKVD 1164 RDL + N L+GE+ VKVADFG+S L + + G +W APE + + K D Sbjct: 408 RDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSD 467 Query: 1165 VYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATNP 1341 V++FG++LWEI T + P+ + Q + K R P CP + L+ CW +P Sbjct: 468 VWAFGVLLWEIATYGMSPYPGIDLSQ-VYDLLEKGYRMEQPEGCPPKVYELMRACWKWSP 526 Query: 1342 DKRPQF 1359 RP F Sbjct: 527 ADRPSF 532
>P42679:MATK_HUMAN Megakaryocyte-associated tyrosine-protein kinase - Homo sapiens| (Human) Length = 507 Score = 130 bits (327), Expect = 2e-29 Identities = 79/247 (31%), Positives = 132/247 (53%), Gaps = 4/247 (1%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGREVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSF 810 + G V G Y G++VA+K + + D A + F E A++ +++H N+V Sbjct: 240 QIGEGEFGAVLQGEYLGQKVAVKNI----KCDVTA----QAFLDETAVMTKMQHENLVRL 291 Query: 811 VAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGILH 990 + ++ I+ E+++ G+L +L + V +LQ +L +A GM YL S+ ++H Sbjct: 292 LGVILHQGLY-IVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVH 350 Query: 991 RDLKSENVLLGEDMSVKVADFGISCLESQCGSGKGFTGT---YRWMAPEMIKEKNHTRKV 1161 RDL + N+L+ ED+ KV+DFG++ E KG + +W APE +K T K Sbjct: 351 RDLAARNILVSEDLVAKVSDFGLAKAER-----KGLDSSRLPVKWTAPEALKHGKFTSKS 405 Query: 1162 DVYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATN 1338 DV+SFG++LWE+ + P+ +M+ ++ + AV K R P CP + L+S CW Sbjct: 406 DVWSFGVLLWEVFSYGRAPYPKMSLKEVSEAVE-KGYRMEPPEGCPGPVHVLMSSCWEAE 464 Query: 1339 PDKRPQF 1359 P +RP F Sbjct: 465 PARRPPF 471
>Q07014:LYN_RAT Tyrosine-protein kinase Lyn - Rattus norvegicus (Rat)| Length = 512 Score = 130 bits (327), Expect = 2e-29 Identities = 83/262 (31%), Positives = 138/262 (52%), Gaps = 4/262 (1%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGR-EVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVS 807 + +G+ V+ G YN +VA+K + +P A A F E L+ L+H +V Sbjct: 252 KLGAGQFGEVWMGYYNNSTKVAVKTL-KPGTMSAQA------FLEEANLMKTLQHDKLVR 304 Query: 808 FVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGIL 987 A K IITE+MA GSL +L E V + ++ + IA GM+Y+ + + Sbjct: 305 LYAVVTKEEPIYIITEFMAKGSLLDFLKSDEGSKVLLPKLIDFSAQIAEGMAYIERKNYI 364 Query: 988 HRDLKSENVLLGEDMSVKVADFGISCL--ESQCGSGKGFTGTYRWMAPEMIKEKNHTRKV 1161 HRDL++ NVL+ E + K+ADFG++ + +++ + +G +W APE I T K Sbjct: 365 HRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKS 424 Query: 1162 DVYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATN 1338 DV+SFGI+L+EI+T +P+ T A++ + R P +CP + ++ CW + Sbjct: 425 DVWSFGILLYEIVTYGKIPYPGRTNADVMTALS-QGYRMPRMENCPDELYDIMKMCWKES 483 Query: 1339 PDKRPQFDDIVVVLEGYKEALD 1404 ++RP FD + VL+ + A + Sbjct: 484 AEERPTFDYLQSVLDDFYTATE 505
>Q03526:ITK_MOUSE Tyrosine-protein kinase ITK/TSK - Mus musculus (Mouse)| Length = 625 Score = 130 bits (327), Expect = 2e-29 Identities = 84/290 (28%), Positives = 141/290 (48%), Gaps = 10/290 (3%) Frame = +1 Query: 559 AWRQDP----GRRRGALERRPLKARDPGRFASGRHSRVYFGRY-NGREVAIKMVSQPHED 723 +WRQ G R G +P + SG+ V+ G + N +VAIK + + Sbjct: 345 SWRQKAPVTAGLRYGKWVIQPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIQE---- 400 Query: 724 DALAAELERQFASEVALLLRLRHHNIVSFVAACKKPPVFCIITEYMAGGSLRKYLHQQEP 903 A E F E ++++L H +V C + C++ E+M G L YL Q Sbjct: 401 ---GAMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRSQRG 457 Query: 904 HSVPIQLVLQLALDIARGMSYLHSQGILHRDLKSENVLLGEDMSVKVADFGIS--CLESQ 1077 + +L + LD+ GM+YL ++HRDL + N L+GE+ +KV+DFG++ L+ Q Sbjct: 458 -LFAAETLLGMCLDVCEGMAYLEKACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQ 516 Query: 1078 CGSGKGFTGTYRWMAPEMIKEKNHTRKVDVYSFGIVLWEILT-ALVPFSEMTPEQAA--I 1248 S G +W +PE+ ++ K DV+SFG+++WE+ + +P+ + + I Sbjct: 517 YTSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDI 576 Query: 1249 AVALKNARPPLPASCPVAMSHLISQCWATNPDKRPQFDDIVVVLEGYKEA 1398 + + +P L ASC V +++ CW P+ RP F ++ L EA Sbjct: 577 STGFRLYKPRL-ASCHV--YQIMNHCWKEKPEDRPPFSQLLSQLAEIAEA 623
>O08680:EPHA3_RAT Ephrin type-A receptor 3 precursor - Rattus norvegicus (Rat)| Length = 984 Score = 130 bits (327), Expect = 2e-29 Identities = 78/217 (35%), Positives = 115/217 (52%), Gaps = 5/217 (2%) Frame = +1 Query: 748 RQFASEVALLLRLRHHNIVSFVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLV 927 R F E +++ + H NI+ K I+TEYM GSL +L + + IQLV Sbjct: 666 RDFLGEASIMGQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFTVIQLV 725 Query: 928 LQLALDIARGMSYLHSQGILHRDLKSENVLLGEDMSVKVADFGIS-CLESQ---CGSGKG 1095 L IA GM YL G +HRDL + N+L+ ++ KV+DFG+S LE + +G Sbjct: 726 GMLR-GIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRG 784 Query: 1096 FTGTYRWMAPEMIKEKNHTRKVDVYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNAR 1272 RW +PE + T DV+S+GIVLWE+++ P+ EM+ Q I + R Sbjct: 785 GKIPVRWTSPEATAYRKFTSASDVWSYGIVLWEVMSYGERPYWEMS-NQDVIKAVDEGYR 843 Query: 1273 PPLPASCPVAMSHLISQCWATNPDKRPQFDDIVVVLE 1383 PLP CP A+ L+ CW + + RP+F+ IV +L+ Sbjct: 844 LPLPMDCPAALYQLMLDCWQKDRNNRPKFEQIVSILD 880
>P63185:SRC_RSVSE Tyrosine-protein kinase transforming protein Src - Rous sarcoma virus| (strain Schmidt-Ruppin E) (RSV-SR-E) Length = 526 Score = 130 bits (326), Expect = 2e-29 Identities = 81/248 (32%), Positives = 134/248 (54%), Gaps = 4/248 (1%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGR-EVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVS 807 + G V+ G +NG VAIK + + ++ E F E ++ +LRH +V Sbjct: 272 KLGQGCFGEVWMGTWNGTTRVAIKTL----KPGTMSPEA---FLQEAQVMKKLRHKKLVQ 324 Query: 808 FVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGIL 987 A + P++ +I EYM+ GSL +L + + + ++ +A IA GM+Y+ + Sbjct: 325 LYAVVSEEPIYIVI-EYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERMNYV 383 Query: 988 HRDLKSENVLLGEDMSVKVADFGISCL--ESQCGSGKGFTGTYRWMAPEMIKEKNHTRKV 1161 HRDL++ N+L+GE++ KVADFG++ L +++ + +G +W APE T K Sbjct: 384 HRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKS 443 Query: 1162 DVYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATN 1338 DV+SFGI+L E+ T VP+ M + V + R P P CP ++ L+SQCW + Sbjct: 444 DVWSFGILLTELTTKGRVPYPGMGNGEVLDRVE-RGYRMPCPPECPESLHDLMSQCWRRD 502 Query: 1339 PDKRPQFD 1362 P++RP F+ Sbjct: 503 PEERPTFE 510
>P09769:FGR_HUMAN Proto-oncogene tyrosine-protein kinase FGR - Homo sapiens (Human)| Length = 529 Score = 130 bits (326), Expect = 2e-29 Identities = 77/257 (29%), Positives = 131/257 (50%), Gaps = 4/257 (1%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGR-EVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVS 807 R +G V+ G +NG +VA+K + + F E ++ LRH +V Sbjct: 268 RLGTGCFGDVWLGTWNGSTKVAVKTLKP-------GTMSPKAFLEEAQVMKLLRHDKLVQ 320 Query: 808 FVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGIL 987 A + P++ I+TE+M GSL +L E + + ++ +A +A GM+Y+ + Sbjct: 321 LYAVVSEEPIY-IVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERMNYI 379 Query: 988 HRDLKSENVLLGEDMSVKVADFGISCL--ESQCGSGKGFTGTYRWMAPEMIKEKNHTRKV 1161 HRDL++ N+L+GE ++ K+ADFG++ L + + +G +W APE T K Sbjct: 380 HRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGRFTIKS 439 Query: 1162 DVYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATN 1338 DV+SFGI+L E++T +P+ M + V + P P CP ++ + Q W + Sbjct: 440 DVWSFGILLTELITKGRIPYPGMNKREVLEQVE-QGYHMPCPPGCPASLYEAMEQTWRLD 498 Query: 1339 PDKRPQFDDIVVVLEGY 1389 P++RP F+ + LE Y Sbjct: 499 PEERPTFEYLQSFLEDY 515
>P54756:EPHA5_HUMAN Ephrin type-A receptor 5 precursor - Homo sapiens (Human)| Length = 1037 Score = 130 bits (326), Expect = 2e-29 Identities = 79/217 (36%), Positives = 115/217 (52%), Gaps = 5/217 (2%) Frame = +1 Query: 748 RQFASEVALLLRLRHHNIVSFVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLV 927 R F E +++ + H NI+ K I+TEYM GSL +L + + IQLV Sbjct: 719 RDFLGEASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLV 778 Query: 928 LQLALDIARGMSYLHSQGILHRDLKSENVLLGEDMSVKVADFGIS-CLESQ---CGSGKG 1095 L I+ GM YL G +HRDL + N+L+ ++ KV+DFG+S LE + +G Sbjct: 779 GMLR-GISAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRG 837 Query: 1096 FTGTYRWMAPEMIKEKNHTRKVDVYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNAR 1272 RW APE I + T DV+S+GIV+WE+++ P+ EMT Q I + R Sbjct: 838 GKIPIRWTAPEAIAFRKFTSASDVWSYGIVMWEVVSYGERPYWEMT-NQDVIKAVEEGYR 896 Query: 1273 PPLPASCPVAMSHLISQCWATNPDKRPQFDDIVVVLE 1383 P P CP A+ L+ CW + RP+FD+IV +L+ Sbjct: 897 LPSPMDCPAALYQLMLDCWQKERNSRPKFDEIVNMLD 933
>Q91736:EPB1B_XENLA Ephrin type-B receptor 1-B - Xenopus laevis (African clawed frog)| Length = 902 Score = 130 bits (326), Expect = 2e-29 Identities = 86/260 (33%), Positives = 133/260 (51%), Gaps = 12/260 (4%) Frame = +1 Query: 640 SGRHSRVYFGRY---NGRE--VAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIV 804 +G VY GR + RE VAIK + + + + R F SE +++ + H NI+ Sbjct: 545 AGEFGEVYKGRLKLPSKREISVAIKTLKAGYSE-----KQRRDFLSEASIMGQFDHPNII 599 Query: 805 SFVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGI 984 K IITE+M G+L +L Q + IQLV L IA GM YL Sbjct: 600 RLEGVVTKSRPVMIITEFMENGALDSFLRQNDGQFTVIQLVGMLR-GIAAGMKYLSEMNY 658 Query: 985 LHRDLKSENVLLGEDMSVKVADFGISCLESQCGSGKGFTGT------YRWMAPEMIKEKN 1146 +HRDL + N+L+ ++ KV+DFG+S S +T + RW APE I+ + Sbjct: 659 VHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTAPEAIRYRK 718 Query: 1147 HTRKVDVYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQ 1323 T DV+S+GIV+WE+++ P+ +M+ + A+ ++ R P P CP A+ L+ Sbjct: 719 FTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVINAIE-QDYRLPPPMDCPAALHQLMLD 777 Query: 1324 CWATNPDKRPQFDDIVVVLE 1383 CW + + RP+F +IV L+ Sbjct: 778 CWQKDRNSRPRFGEIVNTLD 797
>P32577:CSK_RAT Tyrosine-protein kinase CSK - Rattus norvegicus (Rat)| Length = 450 Score = 130 bits (326), Expect = 2e-29 Identities = 90/269 (33%), Positives = 136/269 (50%), Gaps = 5/269 (1%) Frame = +1 Query: 568 QDPGRRRG-ALERRPLKARDPGRFASGRHSRVYFGRYNGREVAIKMVSQPHEDDALAAEL 744 QD R G AL + LK G V G Y G +VA+K + ++DA A Sbjct: 180 QDEFYRSGWALNMKELKLLQT--IGKGEFGDVMLGDYRGNKVAVKCI----KNDATA--- 230 Query: 745 ERQFASEVALLLRLRHHNIVSFVAAC-KKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQ 921 + F +E +++ +LRH N+V + ++ I+TEYMA GSL YL + + Sbjct: 231 -QAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGD 289 Query: 922 LVLQLALDIARGMSYLHSQGILHRDLKSENVLLGEDMSVKVADFGISCLESQCGSGKGFT 1101 +L+ +LD+ M YL +HRDL + NVL+ ED KV+DFG+ ++ S T Sbjct: 290 CLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGL----TKEASSTQDT 345 Query: 1102 G--TYRWMAPEMIKEKNHTRKVDVYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNAR 1272 G +W APE ++EK + K DV+SFGI+LWEI + VP+ + P + + K + Sbjct: 346 GKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRI-PLKDVVPRVEKGYK 404 Query: 1273 PPLPASCPVAMSHLISQCWATNPDKRPQF 1359 P CP A+ ++ CW + RP F Sbjct: 405 MDAPDGCPPAVYDVMKNCWHLDAATRPTF 433
>P35991:BTK_MOUSE Tyrosine-protein kinase BTK - Mus musculus (Mouse)| Length = 659 Score = 130 bits (326), Expect = 2e-29 Identities = 81/263 (30%), Positives = 133/263 (50%), Gaps = 6/263 (2%) Frame = +1 Query: 640 SGRHSRVYFGRYNGR-EVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSFVA 816 +G+ V +G++ G+ +VAIKM+ + + E +F E +++ L H +V Sbjct: 410 TGQFGVVKYGKWRGQYDVAIKMIRE-------GSMSEDEFIEEAKVMMNLSHEKLVQLYG 462 Query: 817 ACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGILHRD 996 C K IITEYMA G L YL + H Q +L++ D+ M YL S+ LHRD Sbjct: 463 VCTKQRPIFIITEYMANGCLLNYLREMR-HRFQTQQLLEMCKDVCEAMEYLESKQFLHRD 521 Query: 997 LKSENVLLGEDMSVKVADFGIS--CLESQCGSGKGFTGTYRWMAPEMIKEKNHTRKVDVY 1170 L + N L+ + VKV+DFG+S L+ + S G RW PE++ + K D++ Sbjct: 522 LAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIW 581 Query: 1171 SFGIVLWEILT-ALVPFSEMTPEQAA--IAVALKNARPPLPASCPVAMSHLISQCWATNP 1341 +FG+++WEI + +P+ T + A IA L+ RP L + + ++ CW Sbjct: 582 AFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASE---RVYTIMYSCWHEKA 638 Query: 1342 DKRPQFDDIVVVLEGYKEALDND 1410 D+RP F ++L + +D + Sbjct: 639 DERPSFK---ILLSNILDVMDEE 658
>Q06187:BTK_HUMAN Tyrosine-protein kinase BTK - Homo sapiens (Human)| Length = 659 Score = 130 bits (326), Expect = 2e-29 Identities = 81/263 (30%), Positives = 133/263 (50%), Gaps = 6/263 (2%) Frame = +1 Query: 640 SGRHSRVYFGRYNGR-EVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSFVA 816 +G+ V +G++ G+ +VAIKM+ + + E +F E +++ L H +V Sbjct: 410 TGQFGVVKYGKWRGQYDVAIKMIKE-------GSMSEDEFIEEAKVMMNLSHEKLVQLYG 462 Query: 817 ACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGILHRD 996 C K IITEYMA G L YL + H Q +L++ D+ M YL S+ LHRD Sbjct: 463 VCTKQRPIFIITEYMANGCLLNYLREMR-HRFQTQQLLEMCKDVCEAMEYLESKQFLHRD 521 Query: 997 LKSENVLLGEDMSVKVADFGIS--CLESQCGSGKGFTGTYRWMAPEMIKEKNHTRKVDVY 1170 L + N L+ + VKV+DFG+S L+ + S G RW PE++ + K D++ Sbjct: 522 LAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIW 581 Query: 1171 SFGIVLWEILT-ALVPFSEMTPEQAA--IAVALKNARPPLPASCPVAMSHLISQCWATNP 1341 +FG+++WEI + +P+ T + A IA L+ RP L + + ++ CW Sbjct: 582 AFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASE---KVYTIMYSCWHEKA 638 Query: 1342 DKRPQFDDIVVVLEGYKEALDND 1410 D+RP F ++L + +D + Sbjct: 639 DERPTFK---ILLSNILDVMDEE 658
>P25020:SRC_RSVH1 Tyrosine-protein kinase transforming protein Src - Rous sarcoma virus| (strain H-19) Length = 526 Score = 129 bits (325), Expect = 3e-29 Identities = 85/268 (31%), Positives = 138/268 (51%), Gaps = 4/268 (1%) Frame = +1 Query: 568 QDPGRRRGALERRPLKARDPGRFASGRHSRVYFGRYNGR-EVAIKMVSQPHEDDALAAEL 744 Q G + A E R + G V+ G +NG VAIK + + ++ E Sbjct: 251 QTQGLAKDAWEIPRESLRLEAKLGQGCFGEVWMGTWNGTTRVAIKTL----KPGTMSPEA 306 Query: 745 ERQFASEVALLLRLRHHNIVSFVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQL 924 F E ++ +LRH +V A + P++ +I EYM+ GSL +L + + + Sbjct: 307 ---FLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVI-EYMSKGSLLDFLKGEMGKYLRLPQ 362 Query: 925 VLQLALDIARGMSYLHSQGILHRDLKSENVLLGEDMSVKVADFGISCL--ESQCGSGKGF 1098 ++ +A IA GM+Y+ +HRDL++ N+L+GE++ KVADFG++ L +++ + +G Sbjct: 363 LVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGA 422 Query: 1099 TGTYRWMAPEMIKEKNHTRKVDVYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARP 1275 +W APE T K DV+SFGI+L E+ T VP+ M + V + R Sbjct: 423 KFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVE-RAYRM 481 Query: 1276 PLPASCPVAMSHLISQCWATNPDKRPQF 1359 P P CP ++ L+ QCW +P++RP F Sbjct: 482 PCPPECPESLHDLMCQCWRKDPEERPTF 509
>P25848:PHY1_CERPU Light-sensor Protein kinase [Includes: Phytochrome; Protein kinase -| Ceratodon purpureus (Moss) Length = 1307 Score = 129 bits (325), Expect = 3e-29 Identities = 102/304 (33%), Positives = 138/304 (45%), Gaps = 41/304 (13%) Frame = +1 Query: 628 GRFASGRHSRVYFGRYNGREVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVS 807 G SG + V + G VA K + +D F EV +L L H NI S Sbjct: 1008 GSLGSGSSATVEKAVWLGTPVAKKTFYGRNNED---------FKREVEILAELCHPNITS 1058 Query: 808 FVAACKKPPVFCIITEYMAGGSL---RKYLHQQEPHSVP---IQLVLQLALDIARGMSYL 969 + II E M G L ++ L + E H P I V+ + L + GM+YL Sbjct: 1059 MFCSPLYRRKCSIIMELMDGDLLALMQRRLDRNEDHDSPPFSILEVVDIILQTSEGMNYL 1118 Query: 970 HSQGILHRDLKSENVLLGED---------MSVKVADFGISCLESQCGSGKGFT---GTYR 1113 H +GI+HRDLKS N+L+ + VKVADFG+S + T GT R Sbjct: 1119 HEKGIIHRDLKSMNILVKSVKVTKSEIGYVHVKVADFGLSKTKDSSTRYSNQTWNRGTNR 1178 Query: 1114 WMAPEMI---------------KEKNHTRKVDVYSFGIVLWEILTALVPFSEMTPEQAAI 1248 WMAPE+I K + K DVYSFG+V +E+LT VPF E Sbjct: 1179 WMAPEVINLGYESTEGEISFDGKVPKYPLKSDVYSFGMVCYEVLTGDVPFPEEKNPNNVK 1238 Query: 1249 AVALKNARPPLPASCPVAMSHLISQCWATNPDKRPQFDDI--------VVVLEGYKEALD 1404 + L+ RP LPA CP+ + LI+ CW +P KRP F I +++ G+ D Sbjct: 1239 RMVLEGVRPDLPAHCPIELKALITDCWNQDPLKRPSFAVICQKLKYLKYLLMTGFSSYQD 1298 Query: 1405 NDPS 1416 + PS Sbjct: 1299 SYPS 1302
>O15146:MUSK_HUMAN Muscle, skeletal receptor tyrosine protein kinase precursor - Homo| sapiens (Human) Length = 869 Score = 129 bits (325), Expect = 3e-29 Identities = 83/258 (32%), Positives = 126/258 (48%), Gaps = 26/258 (10%) Frame = +1 Query: 688 VAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSFVAACKKPPVFCIITEYMAG 867 VA+KM+ + +A+++ F E AL+ + NIV + C C++ EYMA Sbjct: 606 VAVKMLKEE-----ASADMQADFQREAALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAY 660 Query: 868 GSLRKYLHQQEPHSV--------------------PIQLVLQLAL--DIARGMSYLHSQG 981 G L ++L PH+V P+ QL + +A GM+YL + Sbjct: 661 GDLNEFLRSMSPHTVCSLSHSDLSMRAQVSSPGPPPLSCAEQLCIARQVAAGMAYLSERK 720 Query: 982 ILHRDLKSENVLLGEDMSVKVADFGIS---CLESQCGSGKGFTGTYRWMAPEMIKEKNHT 1152 +HRDL + N L+GE+M VK+ADFG+S + + RWM PE I +T Sbjct: 721 FVHRDLATRNCLVGENMVVKIADFGLSRNIYSADYYKANENDAIPIRWMPPESIFYNRYT 780 Query: 1153 RKVDVYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCW 1329 + DV+++G+VLWEI + L P+ M E+ V N P +CPV + +L+ CW Sbjct: 781 TESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYVRDGNIL-SCPENCPVELYNLMRLCW 839 Query: 1330 ATNPDKRPQFDDIVVVLE 1383 + P RP F I +LE Sbjct: 840 SKLPADRPSFTSIHRILE 857
>P07948:LYN_HUMAN Tyrosine-protein kinase Lyn - Homo sapiens (Human)| Length = 512 Score = 129 bits (325), Expect = 3e-29 Identities = 81/262 (30%), Positives = 134/262 (51%), Gaps = 4/262 (1%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGR-EVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVS 807 R +G+ V+ G YN +VA+K + + F E L+ L+H +V Sbjct: 252 RLGAGQFGEVWMGYYNNSTKVAVKTLKP-------GTMSVQAFLEEANLMKTLQHDKLVR 304 Query: 808 FVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGIL 987 A + IITEYMA GSL +L E V + ++ + IA GM+Y+ + + Sbjct: 305 LYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYI 364 Query: 988 HRDLKSENVLLGEDMSVKVADFGISCL--ESQCGSGKGFTGTYRWMAPEMIKEKNHTRKV 1161 HRDL++ NVL+ E + K+ADFG++ + +++ + +G +W APE I T K Sbjct: 365 HRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKS 424 Query: 1162 DVYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATN 1338 DV+SFGI+L+EI+T +P+ T A++ + R P +CP + ++ CW Sbjct: 425 DVWSFGILLYEIVTYGKIPYPGRTNADVMTALS-QGYRMPRVENCPDELYDIMKMCWKEK 483 Query: 1339 PDKRPQFDDIVVVLEGYKEALD 1404 ++RP FD + VL+ + A + Sbjct: 484 AEERPTFDYLQSVLDDFYTATE 505
>P29320:EPHA3_HUMAN Ephrin type-A receptor 3 precursor - Homo sapiens (Human)| Length = 983 Score = 129 bits (325), Expect = 3e-29 Identities = 78/217 (35%), Positives = 115/217 (52%), Gaps = 5/217 (2%) Frame = +1 Query: 748 RQFASEVALLLRLRHHNIVSFVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLV 927 R F E +++ + H NI+ K I+TEYM GSL +L + + IQLV Sbjct: 665 RDFLGEASIMGQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFTVIQLV 724 Query: 928 LQLALDIARGMSYLHSQGILHRDLKSENVLLGEDMSVKVADFGIS-CLESQ---CGSGKG 1095 L IA GM YL G +HRDL + N+L+ ++ KV+DFG+S LE + +G Sbjct: 725 GMLR-GIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRG 783 Query: 1096 FTGTYRWMAPEMIKEKNHTRKVDVYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNAR 1272 RW +PE I + T DV+S+GIVLWE+++ P+ EM+ Q I + R Sbjct: 784 GKIPIRWTSPEAIAYRKFTSASDVWSYGIVLWEVMSYGERPYWEMS-NQDVIKAVDEGYR 842 Query: 1273 PPLPASCPVAMSHLISQCWATNPDKRPQFDDIVVVLE 1383 P P CP A+ L+ CW + + RP+F+ IV +L+ Sbjct: 843 LPPPMDCPAALYQLMLDCWQKDRNNRPKFEQIVSILD 879
>P31693:SRC_RSVPA Tyrosine-protein kinase transforming protein Src - Rous sarcoma virus| (strain PA101T) Length = 523 Score = 129 bits (324), Expect = 4e-29 Identities = 80/248 (32%), Positives = 133/248 (53%), Gaps = 4/248 (1%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGR-EVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVS 807 + G V+ G +NG VAIK + + ++ E F E ++ +LRH +V Sbjct: 269 KLGQGYFGEVWMGTWNGTTRVAIKTL----KPGTMSPEA---FLQEAQVMKKLRHEKLVQ 321 Query: 808 FVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGIL 987 A + P++ +I EYM+ GSL +L + + + ++++A IA GM+Y+ + Sbjct: 322 LYAMVSEEPIYIVI-EYMSKGSLLDFLKGEMGKYLRLPQLVEMAAQIASGMAYVERMNYV 380 Query: 988 HRDLKSENVLLGEDMSVKVADFGISCL--ESQCGSGKGFTGTYRWMAPEMIKEKNHTRKV 1161 HRDL++ N+L+GE++ KVADFG++ L +++ + G +W APE T K Sbjct: 381 HRDLRAANILVGENLVCKVADFGLARLIEDNEYTARPGARFPVKWTAPEAALYGRFTIKS 440 Query: 1162 DVYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATN 1338 DV+SFGI+L E+ T VP+ M + V + R P P CP ++ L+ QCW + Sbjct: 441 DVWSFGILLTELTTKGRVPYPGMVNGEVLDRVE-RGYRMPCPPECPESLHDLMCQCWRKD 499 Query: 1339 PDKRPQFD 1362 P++RP F+ Sbjct: 500 PEERPTFE 507
>P00536:MOS_MOUSE Proto-oncogene serine/threonine-protein kinase mos - Mus musculus| (Mouse) Length = 390 Score = 129 bits (324), Expect = 4e-29 Identities = 99/280 (35%), Positives = 142/280 (50%), Gaps = 23/280 (8%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGREVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSF 810 R SG VY Y+G VAIK V++ +D L A +R F +E+ + RLRH NIV Sbjct: 115 RLGSGGFGSVYKATYHGVPVAIKQVNKCTKD--LRAS-QRSFWAELNIA-RLRHDNIVRV 170 Query: 811 VAACKKPP-----VFCIITEYMAGGSLRKYLH----QQEPHSVPIQL----VLQLALDIA 951 VAA + P + II E+ +L + ++ EP S QL L+ +LD+ Sbjct: 171 VAASTRTPEDSNSLGTIIMEFGGNVTLHQVIYGATRSPEPLSCREQLSLGKCLKYSLDVV 230 Query: 952 RGMSYLHSQGILHRDLKSENVLLGEDMSVKVADFGIS----CLESQCGSGKGFTGTYRWM 1119 G+ +LHSQ ILH DLK N+L+ E K++DFG S L + S GTY Sbjct: 231 NGLLFLHSQSILHLDLKPANILISEQDVCKISDFGCSQKLQVLRCRQASPHHIGGTYTHQ 290 Query: 1120 APEMIKEKNHTRKVDVYSFGIVLWEILTALVPFSEMTPEQAAIAVALKNARPPLPASCPV 1299 APE++K + T K D+YSFGI LW++ T VP+S P+ AV N RP L + Sbjct: 291 APEILKGEIATPKADIYSFGITLWQMTTREVPYSG-EPQYVQYAVVAYNLRPSLAGAVFT 349 Query: 1300 A------MSHLISQCWATNPDKRPQFDDIVVVLEGYKEAL 1401 A + ++I CW +RP + + L+ ++ AL Sbjct: 350 ASLTGKTLQNIIQSCWEARALQRPCAELLQRDLKAFRGAL 389
>P18106:FPS_DROME Tyrosine-protein kinase Fps85D - Drosophila melanogaster (Fruit fly)| Length = 1325 Score = 129 bits (324), Expect = 4e-29 Identities = 86/263 (32%), Positives = 129/263 (49%), Gaps = 4/263 (1%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGR--EVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIV 804 R G VY + +VA+K D E +R+F E +L + H NIV Sbjct: 1068 RIGRGNFGDVYKAKLKSTKLDVAVKTCRMTLPD-----EQKRKFLQEGRILKQYDHPNIV 1122 Query: 805 SFVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGI 984 + C + I+ E + GGSL YL + + + + + + D A GM YL S+ Sbjct: 1123 KLIGICVQKQPIMIVMELVLGGSLLTYLRKNS-NGLTTRQQMGMCRDAAAGMRYLESKNC 1181 Query: 985 LHRDLKSENVLLGEDMSVKVADFGISCLESQCGSGKGFTG-TYRWMAPEMIKEKNHTRKV 1161 +HRDL + N L+ + SVK++DFG+S E + G +W APE + +T Sbjct: 1182 IHRDLAARNCLVDLEHSVKISDFGMSREEEEYIVSDGMKQIPVKWTAPEALNFGKYTSLC 1241 Query: 1162 DVYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATN 1338 DV+S+GI++WEI + P+S MT +A + R P P S P M L+ QCWA + Sbjct: 1242 DVWSYGILMWEIFSKGDTPYSGMTNSRARERID-TGYRMPTPKSTPEEMYRLMLQCWAAD 1300 Query: 1339 PDKRPQFDDIVVVLEGYKEALDN 1407 + RP FD+I V++ LDN Sbjct: 1301 AESRPHFDEIYNVVDALILRLDN 1323
>P14234:FGR_MOUSE Proto-oncogene tyrosine-protein kinase FGR - Mus musculus (Mouse)| Length = 517 Score = 129 bits (324), Expect = 4e-29 Identities = 85/281 (30%), Positives = 140/281 (49%), Gaps = 4/281 (1%) Frame = +1 Query: 559 AWRQDPGRRRGALERRPLKARDPGRFASGRHSRVYFGRYN-GREVAIKMVSQPHEDDALA 735 AW D R ALERR +G V+ G +N +VA+K + Sbjct: 243 AWEID--RNSIALERR---------LGTGCFGDVWLGTWNCSTKVAVKTLKP-------G 284 Query: 736 AELERQFASEVALLLRLRHHNIVSFVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVP 915 + F E ++ LRH +V A + P++ I+TE+M GSL +L +E ++ Sbjct: 285 TMSPKAFLEEAQIMKLLRHDKLVQLYAVVSEEPIY-IVTEFMCYGSLLDFLKDREGQNLM 343 Query: 916 IQLVLQLALDIARGMSYLHSQGILHRDLKSENVLLGEDMSVKVADFGISCL--ESQCGSG 1089 + ++ +A +A GM+Y+ +HRDL++ N+L+GE + K+ADFG++ L +++ Sbjct: 344 LPHLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGEYLICKIADFGLARLIEDNEYNPQ 403 Query: 1090 KGFTGTYRWMAPEMIKEKNHTRKVDVYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKN 1266 +G +W APE T K DV+SFGI+L E++T VP+ M + V Sbjct: 404 QGTKFPIKWTAPEAALFGRFTVKSDVWSFGILLTELITKGRVPYPGMNNREVLEQVE-HG 462 Query: 1267 ARPPLPASCPVAMSHLISQCWATNPDKRPQFDDIVVVLEGY 1389 P P CP ++ ++ Q W +P++RP F+ + LE Y Sbjct: 463 YHMPCPPGCPASLYEVMEQAWRLDPEERPTFEYLQSFLEDY 503
>P07331:MOS_MSVMH Serine/threonine-protein kinase-transforming protein mos - Moloney| murine sarcoma virus (strain HT-1) Length = 374 Score = 129 bits (323), Expect = 5e-29 Identities = 99/280 (35%), Positives = 142/280 (50%), Gaps = 23/280 (8%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGREVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSF 810 R SG VY Y+G VAIK V++ +D L A +R F +E+ + RLRH NIV Sbjct: 99 RLGSGGFGSVYKATYHGVPVAIKQVNKCTKD--LRAS-QRSFWAELNIA-RLRHDNIVRV 154 Query: 811 VAACKKPP-----VFCIITEYMAGGSLRKYLH----QQEPHSVPIQL----VLQLALDIA 951 VAA + P + II E+ +L + ++ EP S QL L+ +LD+ Sbjct: 155 VAASTRTPEDSNSLGTIIMEFGGNVTLHQVIYGATRSPEPLSCREQLSLGKCLKYSLDVV 214 Query: 952 RGMSYLHSQGILHRDLKSENVLLGEDMSVKVADFGIS----CLESQCGSGKGFTGTYRWM 1119 G+ +LHSQ ILH DLK N+L+ E K++DFG S L + S GTY Sbjct: 215 NGLLFLHSQSILHLDLKPANILISEQDVCKISDFGCSQKLQDLRCRQASPHHIGGTYTHQ 274 Query: 1120 APEMIKEKNHTRKVDVYSFGIVLWEILTALVPFSEMTPEQAAIAVALKNARPPLPASCPV 1299 APE++K + T K D+YSFGI LW++ T VP+S P+ AV N RP L + Sbjct: 275 APEILKGEIATPKADIYSFGITLWQMTTREVPYSG-EPQYVQYAVVAYNLRPSLAGAVFT 333 Query: 1300 A------MSHLISQCWATNPDKRPQFDDIVVVLEGYKEAL 1401 A + ++I CW +RP + + L+ ++ AL Sbjct: 334 ASLTGKTLQNIIQSCWEARALQRPGAELLQRDLKAFRGAL 373
>P51813:BMX_HUMAN Cytoplasmic tyrosine-protein kinase BMX - Homo sapiens (Human)| Length = 675 Score = 129 bits (323), Expect = 5e-29 Identities = 78/256 (30%), Positives = 130/256 (50%), Gaps = 4/256 (1%) Frame = +1 Query: 640 SGRHSRVYFGRYNGR-EVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSFVA 816 SG+ V G++ G+ +VA+KM+ + + E +F E +++L H +V F Sbjct: 425 SGQFGVVQLGKWKGQYDVAVKMIKE-------GSMSEDEFFQEAQTMMKLSHPKLVKFYG 477 Query: 817 ACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGILHRD 996 C K I+TEY++ G L YL P QL L++ D+ GM++L S +HRD Sbjct: 478 VCSKEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQL-LEMCYDVCEGMAFLESHQFIHRD 536 Query: 997 LKSENVLLGEDMSVKVADFGIS--CLESQCGSGKGFTGTYRWMAPEMIKEKNHTRKVDVY 1170 L + N L+ D+ VKV+DFG++ L+ Q S G +W APE+ ++ K DV+ Sbjct: 537 LAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHYFKYSSKSDVW 596 Query: 1171 SFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATNPDK 1347 +FGI++WE+ + P+ Q + V+ + R P + ++ CW P+K Sbjct: 597 AFGILMWEVFSLGKQPYDLYDNSQVVLKVS-QGHRLYRPHLASDTIYQIMYSCWHELPEK 655 Query: 1348 RPQFDDIVVVLEGYKE 1395 RP F ++ +E +E Sbjct: 656 RPTFQQLLSSIEPLRE 671
>P00544:FGR_FSVGR Tyrosine-protein kinase transforming protein Fgr - Feline sarcoma| virus (strain Gardner-Rasheed) Length = 545 Score = 128 bits (322), Expect = 7e-29 Identities = 78/257 (30%), Positives = 132/257 (51%), Gaps = 4/257 (1%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGR-EVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVS 807 R +G V+ G +NG +VA+K + + E E ++ LRH +V Sbjct: 291 RLGTGCFGDVWLGMWNGSTKVAVKTLKPGTMSPKASLE-------EAQIMKLLRHDKLVQ 343 Query: 808 FVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGIL 987 A + P++ I+TE+M GSL ++L QE + + ++ +A +A GM+Y+ + Sbjct: 344 LYAVVPEEPIY-IVTEFMCHGSLLEFLKDQEGQDLTLPQLVDMAAQVAEGMAYMERMDYI 402 Query: 988 HRDLKSENVLLGEDMSVKVADFGISCL--ESQCGSGKGFTGTYRWMAPEMIKEKNHTRKV 1161 HRDL++ N+L+GE + K+ADFG++ L +++ +G +W APE T K Sbjct: 403 HRDLRAANILVGERLVCKIADFGLARLIEDNEYNPRQGAKFPIKWTAPEAALFGRFTIKS 462 Query: 1162 DVYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATN 1338 DV+SFGI+L E+++ VP+ M + V P P CP ++ + Q W + Sbjct: 463 DVWSFGILLTELISKGRVPYPGMNNREVLEQVE-HGYHMPCPPGCPASLYEAMEQTWRLD 521 Query: 1339 PDKRPQFDDIVVVLEGY 1389 P++RP F+ + LE Y Sbjct: 522 PEERPTFEYLQSFLEDY 538
>Q8MY86:FGFR1_DUGJA Fibroblast growth factor receptor 1 precursor - Dugesia japonica| (Planarian) Length = 854 Score = 128 bits (322), Expect = 7e-29 Identities = 83/281 (29%), Positives = 140/281 (49%), Gaps = 20/281 (7%) Frame = +1 Query: 631 RFASGRHSRVYFG-------RYNGREVAIKMVSQPHEDDALAAELERQFASEVALLLRL- 786 + G VY G R N +VA+KM+ D + F E+ ++ + Sbjct: 556 KLGEGAFGMVYEGIANDIGNRSNPIKVAVKMMRDDFSDSNV-----HDFVKEMEIMKHIG 610 Query: 787 RHHNIVSFVAACKKPPVFCIITEYMAGGSLRKYLHQQEPH---------SVPIQLVLQLA 939 RH N++ + C + +I E G+LR ++ + + ++ + Sbjct: 611 RHPNVIQLLGLCTQKGPLRVIVELAPYGNLRDFVRAKNKKYSKSKKIIGNFTSSILCTYS 670 Query: 940 LDIARGMSYLHSQGILHRDLKSENVLLGEDMSVKVADFGISCLESQCGSGK--GFTGTYR 1113 L IARGM+YL S+ ++HRDL + N+L+GE +K+ADFG++ + K G + Sbjct: 671 LQIARGMTYLASRSVVHRDLSARNILVGEHFEMKIADFGLTRIVDYYYRKKTDGIL-PVK 729 Query: 1114 WMAPEMIKEKNHTRKVDVYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPPLPAS 1290 WMAPE + EK +T K DV+S+GI+LWEI T P+S + PE+ + + K + P P Sbjct: 730 WMAPEALLEKKYTTKSDVWSYGILLWEIFTLGDSPYSAILPEK-VVDLIRKGFQNPKPEL 788 Query: 1291 CPVAMSHLISQCWATNPDKRPQFDDIVVVLEGYKEALDNDP 1413 + L+ CW+ + + RP F +IV +L + +D++P Sbjct: 789 ANFEIYRLMQHCWSLSSENRPNFFEIVEILIDIIQRIDDEP 829
>P10421:MOS_MSVTS Serine/threonine-protein kinase-transforming protein mos -| Myeloproliferative sarcoma virus (isolate ts159) Length = 342 Score = 128 bits (321), Expect = 9e-29 Identities = 100/283 (35%), Positives = 143/283 (50%), Gaps = 26/283 (9%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGREVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSF 810 R SG VY Y+G VAIK V++ +D L A +R F +E+ + RLRH NIV Sbjct: 68 RLGSGGFGSVYKATYHGVPVAIKQVNKCTKD--LRAS-QRSFWAELNIA-RLRHDNIVRV 123 Query: 811 VAACKKPP-----VFCIITEYMAGGSLRKYLH----QQEPHSVPIQL----VLQLALDIA 951 VAA + P + II E+ +L + ++ EP S QL L+ +LD+ Sbjct: 124 VAASTRTPEDSNSLGTIIMEFGGNVTLHQVIYGATRSPEPLSCREQLSLGKCLKYSLDVV 183 Query: 952 RGMSYLHSQGILHRDLKSENVLLGEDMSVKVADFGIS-------CLESQCGSGKGFTGTY 1110 G+ +LHSQ ILH DLK N+L+ E K++DFG S C +S G GTY Sbjct: 184 NGLLFLHSQSILHLDLKPANILISEQDVCKISDFGCSQKLQDLRCRQSPHHIG----GTY 239 Query: 1111 RWMAPEMIKEKNHTRKVDVYSFGIVLWEILTALVPFSEMTPEQAAIAVALKNARPPLPAS 1290 APE++K + T K D+YSFGI LW++ T VP+S P+ AV N RP L + Sbjct: 240 THQAPEILKGEIATPKADIYSFGITLWQMTTREVPYSG-EPQYVQYAVVAYNLRPSLTGA 298 Query: 1291 CPVA------MSHLISQCWATNPDKRPQFDDIVVVLEGYKEAL 1401 A + ++I CW +RP + + L+ ++ AL Sbjct: 299 VFTASLTRKTLQNIIQNCWEARALQRPGAELLQRDLKAFRGAL 341
>Q8QFP8:LIMK1_CHICK LIM domain kinase 1 - Gallus gallus (Chicken)| Length = 662 Score = 128 bits (321), Expect = 9e-29 Identities = 82/238 (34%), Positives = 120/238 (50%), Gaps = 16/238 (6%) Frame = +1 Query: 739 ELERQFASEVALLLRLRHHNIVSFVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPI 918 E +R F EV ++ L H N++ F+ K ITEY+ GG+LR + + H P Sbjct: 383 ETQRTFLKEVKVMRCLEHPNVLKFIGVLYKEKRLNFITEYIKGGTLRGLIKSMDSH-YPW 441 Query: 919 QLVLQLALDIARGMSYLHSQGILHRDLKSENVLLGEDMSVKVADFGISCLE--------- 1071 + A DIA GM+YLHS I+HRDL S N L+ E+ SV VADFG++ L Sbjct: 442 SQRVSFAKDIAAGMAYLHSMNIIHRDLNSHNCLVRENKSVVVADFGLARLMVDEKNQPEH 501 Query: 1072 ----SQCGSGKGFT--GTYRWMAPEMIKEKNHTRKVDVYSFGIVLWEILTALVPFSEMTP 1233 + K +T G WMAPEMI +++ KVD++SFGIVL EI+ + + P Sbjct: 502 LQNLKKPDRKKRYTVVGNPYWMAPEMINGRSYDEKVDIFSFGIVLCEIIGRVSADPDYLP 561 Query: 1234 EQAAIAVALKN-ARPPLPASCPVAMSHLISQCWATNPDKRPQFDDIVVVLEGYKEALD 1404 + ++ P +CP + + + C +P+KRP F + LE + LD Sbjct: 562 RTTDFGLNVRGFLERYCPPACPPSFFPIAACCCDLDPEKRPSFSKLEQWLETLRMHLD 619
>P09759:EPHB1_RAT Ephrin type-B receptor 1 precursor - Rattus norvegicus (Rat)| Length = 984 Score = 128 bits (321), Expect = 9e-29 Identities = 86/260 (33%), Positives = 131/260 (50%), Gaps = 12/260 (4%) Frame = +1 Query: 640 SGRHSRVYFGRYN---GRE--VAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIV 804 +G VY GR RE VAIK + + + + R F SE +++ + H NI+ Sbjct: 627 AGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSE-----KQRRDFLSEASIMGQFDHPNII 681 Query: 805 SFVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGI 984 K IITE+M G+L +L Q + IQLV L IA GM YL Sbjct: 682 RLEGVVTKSRPVMIITEFMENGALDSFLRQNDGQFTVIQLVGMLR-GIAAGMKYLSEMNY 740 Query: 985 LHRDLKSENVLLGEDMSVKVADFGISCLESQCGSGKGFTGT------YRWMAPEMIKEKN 1146 +HRDL + N+L+ ++ KV+DFG+S S +T + RW APE I + Sbjct: 741 VHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTAPEAIAYRK 800 Query: 1147 HTRKVDVYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQ 1323 T DV+S+GIV+WE+++ P+ +M+ + A+ ++ R P P CP A+ L+ Sbjct: 801 FTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIE-QDYRLPPPMDCPAALHQLMLD 859 Query: 1324 CWATNPDKRPQFDDIVVVLE 1383 CW + + RP+F +IV L+ Sbjct: 860 CWQKDRNSRPRFAEIVNTLD 879
>Q8CBF3:EPHB1_MOUSE Ephrin type-B receptor 1 precursor - Mus musculus (Mouse)| Length = 984 Score = 128 bits (321), Expect = 9e-29 Identities = 86/260 (33%), Positives = 131/260 (50%), Gaps = 12/260 (4%) Frame = +1 Query: 640 SGRHSRVYFGRYN---GRE--VAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIV 804 +G VY GR RE VAIK + + + + R F SE +++ + H NI+ Sbjct: 627 AGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSE-----KQRRDFLSEASIMGQFDHPNII 681 Query: 805 SFVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGI 984 K IITE+M G+L +L Q + IQLV L IA GM YL Sbjct: 682 RLEGVVTKSRPVMIITEFMENGALDSFLRQNDGQFTVIQLVGMLR-GIAAGMKYLSEMNY 740 Query: 985 LHRDLKSENVLLGEDMSVKVADFGISCLESQCGSGKGFTGT------YRWMAPEMIKEKN 1146 +HRDL + N+L+ ++ KV+DFG+S S +T + RW APE I + Sbjct: 741 VHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTAPEAIAYRK 800 Query: 1147 HTRKVDVYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQ 1323 T DV+S+GIV+WE+++ P+ +M+ + A+ ++ R P P CP A+ L+ Sbjct: 801 FTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIE-QDYRLPPPMDCPAALHQLMLD 859 Query: 1324 CWATNPDKRPQFDDIVVVLE 1383 CW + + RP+F +IV L+ Sbjct: 860 CWQKDRNSRPRFAEIVNTLD 879
>P00526:SRC_RSVP Tyrosine-protein kinase transforming protein Src - Rous sarcoma virus| (strain Prague C) (RSV-PrC) Length = 526 Score = 127 bits (320), Expect = 1e-28 Identities = 84/268 (31%), Positives = 137/268 (51%), Gaps = 4/268 (1%) Frame = +1 Query: 568 QDPGRRRGALERRPLKARDPGRFASGRHSRVYFGRYNGR-EVAIKMVSQPHEDDALAAEL 744 Q G + A E R + G V+ G +N VAIK + + ++ E Sbjct: 251 QTQGLAKDAWEIPRESLRLEAKLGQGCFGEVWMGTWNDTTRVAIKTL----KPGTMSPEA 306 Query: 745 ERQFASEVALLLRLRHHNIVSFVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQL 924 F E ++ +LRH +V A + P++ +I EYM+ GSL +L + + + Sbjct: 307 ---FLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVI-EYMSKGSLLDFLKGEMGKYLRLPQ 362 Query: 925 VLQLALDIARGMSYLHSQGILHRDLKSENVLLGEDMSVKVADFGISCL--ESQCGSGKGF 1098 ++ +A IA GM+Y+ +HRDL++ N+L+GE++ KVADFG++ L +++ + +G Sbjct: 363 LVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGA 422 Query: 1099 TGTYRWMAPEMIKEKNHTRKVDVYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARP 1275 +W APE T K DV+SFGI+L E+ T VP+ M + V + R Sbjct: 423 KFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVE-RGYRM 481 Query: 1276 PLPASCPVAMSHLISQCWATNPDKRPQF 1359 P P CP ++ L+ QCW +P++RP F Sbjct: 482 PCPPECPESLHDLMCQCWRKDPEERPTF 509
>Q64434:PTK6_MOUSE Tyrosine-protein kinase 6 - Mus musculus (Mouse)| Length = 451 Score = 127 bits (320), Expect = 1e-28 Identities = 81/255 (31%), Positives = 133/255 (52%), Gaps = 3/255 (1%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGR-EVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVS 807 + +G V+ + G+ VA+K++S+ D+ L + F +E+ + +LRH +I+S Sbjct: 196 KLGAGYFGEVFEALWKGQVHVAVKVISR---DNLLH---QHTFQAEIQAMKKLRHKHILS 249 Query: 808 FVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGIL 987 A IITE M G+L + L + ++PI ++ A +A GM YL SQ + Sbjct: 250 LYAVATAGDPVYIITELMPKGNLLQLLRDSDEKALPILELVDFASQVAEGMCYLESQNYI 309 Query: 988 HRDLKSENVLLGEDMSVKVADFGISCL-ESQCGSGKGFTGTYRWMAPEMIKEKNHTRKVD 1164 HRDL + NVL+ E+ KV DFG++ L + Y+W APE + +++ K D Sbjct: 310 HRDLAARNVLVTENNLCKVGDFGLARLVKEDIYLSHEHNVPYKWTAPEALSRGHYSIKSD 369 Query: 1165 VYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATNP 1341 V+SFG++L EI + +P+ M+ + + V R P P CP + L+ CW+ +P Sbjct: 370 VWSFGVLLHEIFSRGQMPYPGMSNHETFLRVD-AGYRMPCPLECPPNIHKLMLSCWSRDP 428 Query: 1342 DKRPQFDDIVVVLEG 1386 +RP F D+ L G Sbjct: 429 KQRPCFKDLCEKLTG 443
>P32593:MOS_MSVMT Serine/threonine-protein kinase-transforming protein mos - Moloney| murine sarcoma virus (strain ts110) Length = 354 Score = 127 bits (320), Expect = 1e-28 Identities = 98/280 (35%), Positives = 140/280 (50%), Gaps = 23/280 (8%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGREVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSF 810 R SG VY Y+G VAIK V++ ED L A +R F +E+ + LRH NIV Sbjct: 79 RLGSGGFGSVYKATYHGVPVAIKQVNKCTED--LRAS-QRSFWAELNIA-GLRHDNIVRV 134 Query: 811 VAACKKPP-----VFCIITEYMAGGSLRKYLHQQ----EPHSVPIQL----VLQLALDIA 951 VAA + P + II E+ +L + ++ EP S QL L+ +LD+ Sbjct: 135 VAASTRTPEDSNSLGTIIMEFGGNVTLHQVIYDATRSPEPLSCRKQLSLGKCLKYSLDVV 194 Query: 952 RGMSYLHSQGILHRDLKSENVLLGEDMSVKVADFGIS----CLESQCGSGKGFTGTYRWM 1119 G+ +LHSQ ILH DLK N+L+ E K++DFG S L + S GTY Sbjct: 195 NGLLFLHSQSILHLDLKPANILISEQDVCKISDFGCSQKLQVLRGRQASPPHIGGTYTHQ 254 Query: 1120 APEMIKEKNHTRKVDVYSFGIVLWEILTALVPFSEMTPEQAAIAVALKNARPPLPAS--- 1290 APE++K + T K D+YSFGI LW++ T VP+S P+ AV N RP L + Sbjct: 255 APEILKGEIATPKADIYSFGITLWQMTTREVPYSG-EPQYVQYAVVAYNLRPSLAGAVFT 313 Query: 1291 ---CPVAMSHLISQCWATNPDKRPQFDDIVVVLEGYKEAL 1401 A+ ++I CW +RP + + L+ ++ L Sbjct: 314 ASLTGKALQNIIQSCWEARGLQRPSAELLQRDLKAFRGTL 353
>P25911:LYN_MOUSE Tyrosine-protein kinase Lyn - Mus musculus (Mouse)| Length = 512 Score = 127 bits (320), Expect = 1e-28 Identities = 80/262 (30%), Positives = 134/262 (51%), Gaps = 4/262 (1%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGR-EVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVS 807 + +G+ V+ G YN +VA+K + + F E L+ L+H +V Sbjct: 252 KLGAGQFGEVWMGYYNNSTKVAVKTLKP-------GTMSVQAFLEEANLMKTLQHDKLVR 304 Query: 808 FVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGIL 987 A K IITE+MA GSL +L E V + ++ + IA GM+Y+ + + Sbjct: 305 LYAVVTKEEPIYIITEFMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYI 364 Query: 988 HRDLKSENVLLGEDMSVKVADFGISCL--ESQCGSGKGFTGTYRWMAPEMIKEKNHTRKV 1161 HRDL++ NVL+ E + K+ADFG++ + +++ + +G +W APE I T K Sbjct: 365 HRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKS 424 Query: 1162 DVYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATN 1338 DV+SFGI+L+EI+T +P+ T A++ + R P +CP + ++ CW Sbjct: 425 DVWSFGILLYEIVTYGKIPYPGRTNADVMSALS-QGYRMPRMENCPDELYDIMKMCWKEK 483 Query: 1339 PDKRPQFDDIVVVLEGYKEALD 1404 ++RP FD + VL+ + A + Sbjct: 484 AEERPTFDYLQSVLDDFYTATE 505
>P70451:FER_MOUSE Proto-oncogene tyrosine-protein kinase FER - Mus musculus (Mouse)| Length = 823 Score = 127 bits (320), Expect = 1e-28 Identities = 82/248 (33%), Positives = 130/248 (52%), Gaps = 6/248 (2%) Frame = +1 Query: 643 GRHSRVYFGRYNGRE-VAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSFVAA 819 G VY G + VAIK + L EL+ +F E +L + H NIV + Sbjct: 573 GNFGEVYKGTLKDKTPVAIKTCKED-----LPQELKIKFLQEAKILKQYDHPNIVKLIGV 627 Query: 820 CKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGILHRDL 999 C + II E + GG +L +++ QLV + +LD+A GM YL S+ +HRDL Sbjct: 628 CTQRQPVYIIMELVPGGDFLTFLRKRKDELKLKQLV-RFSLDVAAGMLYLESKNCIHRDL 686 Query: 1000 KSENVLLGEDMSVKVADFGISCLESQCGSGKGFTG----TYRWMAPEMIKEKNHTRKVDV 1167 + N L+GE+ ++K++DFG+S E G +G +W APE + ++ + DV Sbjct: 687 AARNCLVGENNTLKISDFGMSRQED--GGVYSSSGLKQIPIKWTAPEALNYGRYSSESDV 744 Query: 1168 YSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATNPD 1344 +SFGI+LWE + + P+ MT +QA V + R P +CP + ++ +CW P+ Sbjct: 745 WSFGILLWETFSLGVCPYPGMTNQQAREQVE-RGYRMSAPQNCPEEVFTIMMKCWDYKPE 803 Query: 1345 KRPQFDDI 1368 RP+F+D+ Sbjct: 804 NRPKFNDL 811
>P54763:EPHB2_MOUSE Ephrin type-B receptor 2 precursor - Mus musculus (Mouse)| Length = 994 Score = 127 bits (320), Expect = 1e-28 Identities = 80/239 (33%), Positives = 122/239 (51%), Gaps = 7/239 (2%) Frame = +1 Query: 688 VAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSFVAACKKPPVFCIITEYMAG 867 VAIK + + + + R F SE +++ + H N++ K IITE+M Sbjct: 658 VAIKTLKSGYTE-----KQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMEN 712 Query: 868 GSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGILHRDLKSENVLLGEDMSVKVA 1047 GSL +L Q + IQLV L IA GM YL +HRDL + N+L+ ++ KV+ Sbjct: 713 GSLDSFLRQNDGQFTVIQLVGMLR-GIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVS 771 Query: 1048 DFGISCLESQCGSGKGFTGT------YRWMAPEMIKEKNHTRKVDVYSFGIVLWEILT-A 1206 DFG+S S +T RW APE I+ + T DV+S+GIV+WE+++ Sbjct: 772 DFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYG 831 Query: 1207 LVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATNPDKRPQFDDIVVVLE 1383 P+ +MT + A+ ++ R P P CP A+ L+ CW + + RP+F IV L+ Sbjct: 832 ERPYWDMTNQDVINAIE-QDYRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQIVNTLD 889
>P29323:EPHB2_HUMAN Ephrin type-B receptor 2 precursor - Homo sapiens (Human)| Length = 1055 Score = 127 bits (320), Expect = 1e-28 Identities = 80/239 (33%), Positives = 122/239 (51%), Gaps = 7/239 (2%) Frame = +1 Query: 688 VAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSFVAACKKPPVFCIITEYMAG 867 VAIK + + + + R F SE +++ + H N++ K IITE+M Sbjct: 650 VAIKTLKSGYTE-----KQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMEN 704 Query: 868 GSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGILHRDLKSENVLLGEDMSVKVA 1047 GSL +L Q + IQLV L IA GM YL +HRDL + N+L+ ++ KV+ Sbjct: 705 GSLDSFLRQNDGQFTVIQLVGMLR-GIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVS 763 Query: 1048 DFGISCLESQCGSGKGFTGT------YRWMAPEMIKEKNHTRKVDVYSFGIVLWEILT-A 1206 DFG+S S +T RW APE I+ + T DV+S+GIV+WE+++ Sbjct: 764 DFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYG 823 Query: 1207 LVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATNPDKRPQFDDIVVVLE 1383 P+ +MT + A+ ++ R P P CP A+ L+ CW + + RP+F IV L+ Sbjct: 824 ERPYWDMTNQDVINAIE-QDYRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQIVNTLD 881
>P54762:EPHB1_HUMAN Ephrin type-B receptor 1 precursor - Homo sapiens (Human)| Length = 984 Score = 127 bits (320), Expect = 1e-28 Identities = 86/260 (33%), Positives = 131/260 (50%), Gaps = 12/260 (4%) Frame = +1 Query: 640 SGRHSRVYFGRYN---GRE--VAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIV 804 +G VY GR RE VAIK + + + + R F SE +++ + H NI+ Sbjct: 627 AGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSE-----KQRRDFLSEASIMGQFDHPNII 681 Query: 805 SFVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGI 984 K IITE+M G+L +L Q + IQLV L IA GM YL Sbjct: 682 RLEGVVTKSRPVMIITEFMENGALDSFLRQNDGQFTVIQLVGMLR-GIAAGMKYLAEMNY 740 Query: 985 LHRDLKSENVLLGEDMSVKVADFGISCLESQCGSGKGFTGT------YRWMAPEMIKEKN 1146 +HRDL + N+L+ ++ KV+DFG+S S +T + RW APE I + Sbjct: 741 VHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTAPEAIAYRK 800 Query: 1147 HTRKVDVYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQ 1323 T DV+S+GIV+WE+++ P+ +M+ + A+ ++ R P P CP A+ L+ Sbjct: 801 FTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIE-QDYRLPPPMDCPAALHQLMLD 859 Query: 1324 CWATNPDKRPQFDDIVVVLE 1383 CW + + RP+F +IV L+ Sbjct: 860 CWQKDRNSRPRFAEIVNTLD 879
>P97504:BMX_MOUSE Cytoplasmic tyrosine-protein kinase BMX - Mus musculus (Mouse)| Length = 651 Score = 127 bits (320), Expect = 1e-28 Identities = 75/255 (29%), Positives = 126/255 (49%), Gaps = 3/255 (1%) Frame = +1 Query: 640 SGRHSRVYFGRYNGR-EVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSFVA 816 +G+ V G++ G+ +VA+KM+ + A E +F E +++L H +V F Sbjct: 401 NGQFGVVQLGQWKGQYDVAVKMIKE-------GAMSEDEFFQEAQTMMKLSHPKLVKFYG 453 Query: 817 ACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGILHRD 996 C K I+TEY+ G L YL QL L++ D+ GM++L S +HRD Sbjct: 454 VCSKKYPIYIVTEYITNGCLLNYLKSHGKGLESCQL-LEMCYDVCEGMAFLESHQFIHRD 512 Query: 997 LKSENVLLGEDMSVKVADFGIS--CLESQCGSGKGFTGTYRWMAPEMIKEKNHTRKVDVY 1170 L + N L+ D+SVKV+DFG++ L+ Q S G +W APE+ ++ K DV+ Sbjct: 513 LAARNCLVDSDLSVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHYFKYSSKSDVW 572 Query: 1171 SFGIVLWEILTALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATNPDKR 1350 +FGI++WE+ + ++ + + R P + ++ CW P+KR Sbjct: 573 AFGILMWEVFSLGKQPYDLYDNSEVVVKVSQGHRLYRPQLASDTIYQIMYSCWHELPEKR 632 Query: 1351 PQFDDIVVVLEGYKE 1395 P F ++ +E +E Sbjct: 633 PTFQQLLSAIEPLRE 647
>P00537:MOS_MSVMM Serine/threonine-protein kinase-transforming protein mos - Moloney| murine sarcoma virus (strain m1) Length = 376 Score = 127 bits (319), Expect = 2e-28 Identities = 96/264 (36%), Positives = 134/264 (50%), Gaps = 23/264 (8%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGREVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSF 810 R SG VY Y+G VAIK V++ +D L A +R F +E+ + RLRH NIV Sbjct: 99 RLGSGGFGSVYKATYHGVPVAIKQVNKCTKD--LRAS-QRSFWAELNIA-RLRHDNIVRV 154 Query: 811 VAACKKPP-----VFCIITEYMAGGSLRKYLH----QQEPHSVPIQL----VLQLALDIA 951 VAA + P + II E+ +L + ++ EP S QL L+ +LD+ Sbjct: 155 VAASTRTPEDSNSLGTIIMEFGGNVTLHQVIYGATRSPEPLSCREQLSLGKCLKYSLDVV 214 Query: 952 RGMSYLHSQGILHRDLKSENVLLGEDMSVKVADFGIS----CLESQCGSGKGFTGTYRWM 1119 G+ +LHSQ ILH DLK N+L+ E K++DFG S L + S GTY Sbjct: 215 NGLLFLHSQSILHLDLKPANILISEQDVCKISDFGCSQKLQDLRCRQASPHHIGGTYTHQ 274 Query: 1120 APEMIKEKNHTRKVDVYSFGIVLWEILTALVPFSEMTPEQAAIAVALKNARPPLPASCPV 1299 APE++K + T K D+YSFGI LW++ T VP+S P+ AV N RP L + Sbjct: 275 APEILKGEIATPKADIYSFGITLWQMTTREVPYSG-EPQYVQYAVVAYNLRPSLAGAVFT 333 Query: 1300 A------MSHLISQCWATNPDKRP 1353 A + ++I CW +RP Sbjct: 334 ASLTGKTLQNIIQSCWEARALQRP 357
>P28693:EPHB2_CHICK Ephrin type-B receptor 2 precursor - Gallus gallus (Chicken)| Length = 1004 Score = 127 bits (319), Expect = 2e-28 Identities = 80/239 (33%), Positives = 122/239 (51%), Gaps = 7/239 (2%) Frame = +1 Query: 688 VAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSFVAACKKPPVFCIITEYMAG 867 VAIK + + + + R F SE +++ + H N++ K IITE+M Sbjct: 668 VAIKTLKSGYTE-----KQRRDFLSEASIMGQFDHPNVIHLEGVVTKSSPVMIITEFMEN 722 Query: 868 GSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGILHRDLKSENVLLGEDMSVKVA 1047 GSL +L Q + IQLV L IA GM YL +HRDL + N+L+ ++ KV+ Sbjct: 723 GSLDSFLRQNDGQFTVIQLVGMLR-GIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVS 781 Query: 1048 DFGISCLESQCGSGKGFTGT------YRWMAPEMIKEKNHTRKVDVYSFGIVLWEILT-A 1206 DFG+S S +T RW APE I+ + T DV+S+GIV+WE+++ Sbjct: 782 DFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYG 841 Query: 1207 LVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATNPDKRPQFDDIVVVLE 1383 P+ +MT + A+ ++ R P P CP A+ L+ CW + + RP+F IV L+ Sbjct: 842 ERPYWDMTNQDVINAIE-QDYRLPPPMDCPNALHQLMLDCWQKDRNHRPKFGQIVNTLD 899
>P29318:EPHA3_CHICK Ephrin type-A receptor 3 precursor - Gallus gallus (Chicken)| Length = 983 Score = 127 bits (319), Expect = 2e-28 Identities = 77/217 (35%), Positives = 115/217 (52%), Gaps = 5/217 (2%) Frame = +1 Query: 748 RQFASEVALLLRLRHHNIVSFVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLV 927 R F E +++ + H NI+ K I+TEYM GSL +L + + IQLV Sbjct: 665 RDFLGEASIMGQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFTVIQLV 724 Query: 928 LQLALDIARGMSYLHSQGILHRDLKSENVLLGEDMSVKVADFGIS-CLESQ---CGSGKG 1095 L IA GM YL G +HRDL + N+L+ ++ KV+DFG+S LE + +G Sbjct: 725 GMLR-GIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRG 783 Query: 1096 FTGTYRWMAPEMIKEKNHTRKVDVYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNAR 1272 RW +PE I + T D +S+GIVLWE+++ P+ EM+ + AV + R Sbjct: 784 GKIPIRWTSPEAIAYRKFTSASDAWSYGIVLWEVMSYGERPYWEMSFQDVIKAVD-EGYR 842 Query: 1273 PPLPASCPVAMSHLISQCWATNPDKRPQFDDIVVVLE 1383 P P CP A+ L+ CW + + RP+F+ IV +L+ Sbjct: 843 LPPPMDCPAALYQLMLDCWQKDRNNRPKFEQIVSILD 879
>P00538:MOS_MSVMO Serine/threonine-protein kinase-transforming protein mos - Moloney| murine sarcoma virus (MoMLV) Length = 374 Score = 127 bits (318), Expect = 2e-28 Identities = 98/280 (35%), Positives = 140/280 (50%), Gaps = 23/280 (8%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGREVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSF 810 R SG VY Y+G VAIK V++ ED L A +R F +E+ + LRH NIV Sbjct: 99 RLGSGGFGSVYKATYHGVPVAIKQVNKCTED--LRAS-QRSFWAELNIA-GLRHDNIVRV 154 Query: 811 VAACKKPP-----VFCIITEYMAGGSLRKYLHQQ----EPHSVPIQL----VLQLALDIA 951 VAA + P + II E+ +L + ++ EP S QL L+ +LD+ Sbjct: 155 VAASTRTPEDSNSLGTIIMEFGGNVTLHQVIYDATRSPEPLSCRKQLSLGKCLKYSLDVV 214 Query: 952 RGMSYLHSQGILHRDLKSENVLLGEDMSVKVADFGIS----CLESQCGSGKGFTGTYRWM 1119 G+ +LHSQ ILH DLK N+L+ E K++DFG S L + S GTY Sbjct: 215 NGLLFLHSQSILHLDLKPANILISEQDVCKISDFGCSQKLQDLRGRQASPPHIGGTYTHQ 274 Query: 1120 APEMIKEKNHTRKVDVYSFGIVLWEILTALVPFSEMTPEQAAIAVALKNARPPLPAS--- 1290 APE++K + T K D+YSFGI LW++ T VP+S P+ AV N RP L + Sbjct: 275 APEILKGEIATPKADIYSFGITLWQMTTREVPYSG-EPQYVQYAVVAYNLRPSLAGAVFT 333 Query: 1291 ---CPVAMSHLISQCWATNPDKRPQFDDIVVVLEGYKEAL 1401 A+ ++I CW +RP + + L+ ++ L Sbjct: 334 ASLTGKALQNIIQSCWEARGLQRPSAELLQRDLKAFRGTL 373
>O13148:EPA4A_DANRE Ephrin type-A receptor 4a - Danio rerio (Zebrafish) (Brachydanio| rerio) Length = 292 Score = 127 bits (318), Expect = 2e-28 Identities = 85/246 (34%), Positives = 125/246 (50%), Gaps = 14/246 (5%) Frame = +1 Query: 688 VAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSFVAACKKPPVFCIITEYMAG 867 VAIK + + D + R F SE +++ + H NI+ K IITEYM Sbjct: 24 VAIKTLKAGYTD-----KQRRDFLSEASIMGQFDHPNIIRLEGVVTKCKPVMIITEYMEN 78 Query: 868 GSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGILHRDLKSENVLLGEDMSVKVA 1047 GSL +L + + IQLV + IA GM YL +HRDL + N+L+ ++ KV+ Sbjct: 79 GSLDAFLRKNDGRFTVIQLV-GILRGIASGMKYLSDMSYVHRDLAARNILVNSNLVCKVS 137 Query: 1048 DFGIS-CLESQCGSG---KGFTGTY---------RWMAPEMIKEKNHTRKVDVYSFGIVL 1188 DFG+S LE + + TGTY RW APE I + T DV+S+GIV+ Sbjct: 138 DFGMSRVLEEDPDAAYTTREITGTYQSQGGKIPIRWTAPEAITYRKFTSASDVWSYGIVM 197 Query: 1189 WEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATNPDKRPQFDD 1365 WE+++ P+ +M+ Q I + R P P CPV++ L+ CW +RP+F Sbjct: 198 WEVMSYGERPYWDMS-NQDVIKAIEEGYRLPPPMDCPVSLHQLMLDCWQKERAERPKFSQ 256 Query: 1366 IVVVLE 1383 IV +L+ Sbjct: 257 IVNMLD 262
>P43298:TMK1_ARATH Putative receptor protein kinase TMK1 precursor - Arabidopsis| thaliana (Mouse-ear cress) Length = 942 Score = 126 bits (317), Expect = 3e-28 Identities = 79/213 (37%), Positives = 120/213 (56%), Gaps = 12/213 (5%) Frame = +1 Query: 640 SGRHSRVYFGR-YNGREVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSFVA 816 SG VY G ++G ++A+K + E+ +A + +F SE+A+L ++RH ++V+ + Sbjct: 596 SGGFGVVYKGELHDGTKIAVKRM----ENGVIAGKGFAEFKSEIAVLTKVRHRHLVTLLG 651 Query: 817 ACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQ---LALDIARGMSYLHS---Q 978 C ++ EYM G+L ++L + + L Q LALD+ARG+ YLH Q Sbjct: 652 YCLDGNEKLLVYEYMPQGTLSRHLFEWSEEGLKPLLWKQRLTLALDVARGVEYLHGLAHQ 711 Query: 979 GILHRDLKSENVLLGEDMSVKVADFGISCLESQCGSGKG-----FTGTYRWMAPEMIKEK 1143 +HRDLK N+LLG+DM KVADFG+ L + GKG GT+ ++APE Sbjct: 712 SFIHRDLKPSNILLGDDMRAKVADFGLVRLAPE---GKGSIETRIAGTFGYLAPEYAVTG 768 Query: 1144 NHTRKVDVYSFGIVLWEILTALVPFSEMTPEQA 1242 T KVDVYSFG++L E++T E PE++ Sbjct: 769 RVTTKVDVYSFGVILMELITGRKSLDESQPEES 801
>P09760:FER_RAT Proto-oncogene tyrosine-protein kinase FER - Rattus norvegicus (Rat)| Length = 323 Score = 126 bits (317), Expect = 3e-28 Identities = 82/259 (31%), Positives = 132/259 (50%), Gaps = 6/259 (2%) Frame = +1 Query: 643 GRHSRVYFGRYNGRE-VAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSFVAA 819 G VY G + VA+K + L EL+ +F E +L + H NIV + Sbjct: 73 GNFGEVYKGTLKDKTPVAVKTCKED-----LPQELKIKFLQEAKILKQYDHPNIVKLIGV 127 Query: 820 CKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGILHRDL 999 C + II E + GG +L +++ QLV + +LD+A GM YL + +HRDL Sbjct: 128 CTQRQPVYIIMELVPGGDFLSFLRKRKDELKLKQLV-RFSLDVAAGMLYLEGKNCIHRDL 186 Query: 1000 KSENVLLGEDMSVKVADFGISCLESQCGSGKGFTG----TYRWMAPEMIKEKNHTRKVDV 1167 + N L+GE+ ++K++DFG+S E G +G +W APE + ++ + DV Sbjct: 187 AARNCLVGENNTLKISDFGMSRQED--GGVYSSSGLKQIPIKWTAPEALNYGRYSSESDV 244 Query: 1168 YSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATNPD 1344 +SFGI+LWE + + P+ MT +QA V + R P +CP + ++ +CW P+ Sbjct: 245 WSFGILLWETFSLGVCPYPGMTNQQAREQVE-RGYRMSAPQNCPEEIFTIMMKCWDYKPE 303 Query: 1345 KRPQFDDIVVVLEGYKEAL 1401 RP+F D+ L K+ + Sbjct: 304 NRPKFSDLHKELTAIKKKI 322
>Q62838:MUSK_RAT Muscle, skeletal receptor tyrosine protein kinase precursor - Rattus| norvegicus (Rat) Length = 868 Score = 126 bits (316), Expect = 3e-28 Identities = 82/258 (31%), Positives = 126/258 (48%), Gaps = 26/258 (10%) Frame = +1 Query: 688 VAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSFVAACKKPPVFCIITEYMAG 867 VA+KM+ + +A+++ F E AL+ + NIV + C C++ EYMA Sbjct: 605 VAVKMLKEE-----ASADMQADFQREAALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAY 659 Query: 868 GSLRKYLHQQEPHSV--------------------PIQLVLQLAL--DIARGMSYLHSQG 981 G L ++L PH+V P+ QL + +A GM+YL + Sbjct: 660 GDLNEFLRSMSPHTVCSLSHSDLSTRARVSSPGPPPLSCAEQLCIARQVAAGMAYLSERK 719 Query: 982 ILHRDLKSENVLLGEDMSVKVADFGIS--CLESQCGSGKGFTG-TYRWMAPEMIKEKNHT 1152 +HRDL + N L+GE+M VK+ADFG+S + G RWM PE I +T Sbjct: 720 FVHRDLATRNCLVGENMVVKIADFGLSRNIYSADYYKADGNDAIPIRWMPPESIFYNRYT 779 Query: 1153 RKVDVYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCW 1329 + DV+++G+VLWEI + L P+ M E+ V N P +CP+ + +L+ CW Sbjct: 780 TESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYVRDGNIL-ACPENCPLELYNLMRLCW 838 Query: 1330 ATNPDKRPQFDDIVVVLE 1383 + P RP F I +L+ Sbjct: 839 SKLPADRPSFCSIHRILQ 856
>Q90344:EPHB2_COTJA Ephrin type-B receptor 2 precursor - Coturnix coturnix japonica| (Japanese quail) Length = 987 Score = 126 bits (316), Expect = 3e-28 Identities = 80/239 (33%), Positives = 121/239 (50%), Gaps = 7/239 (2%) Frame = +1 Query: 688 VAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSFVAACKKPPVFCIITEYMAG 867 VAIK + + + + R F SE +++ + H N++ K IITE+M Sbjct: 651 VAIKTLKSGYTE-----KQRRDFLSEASIMGQFDHPNVIHLEGVVTKSSPVMIITEFMEN 705 Query: 868 GSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGILHRDLKSENVLLGEDMSVKVA 1047 GSL +L Q + IQLV L IA GM YL +HRDL + N L+ ++ KV+ Sbjct: 706 GSLDSFLRQNDGQFTVIQLVGMLR-GIAAGMKYLADMNYVHRDLAARNTLVNSNLVCKVS 764 Query: 1048 DFGISCLESQCGSGKGFTGT------YRWMAPEMIKEKNHTRKVDVYSFGIVLWEILT-A 1206 DFG+S S +T RW APE I+ + T DV+S+GIV+WE+++ Sbjct: 765 DFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYG 824 Query: 1207 LVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATNPDKRPQFDDIVVVLE 1383 P+ +MT + A+ ++ R P P CP A+ L+ CW + + RP+F IV L+ Sbjct: 825 ERPYWDMTNQDVINAIE-QDYRLPPPMDCPNALHQLMLDCWQKDRNHRPKFGQIVNTLD 882
>P08630:BTKL_DROME Tyrosine-protein kinase Btk29A - Drosophila melanogaster (Fruit fly)| Length = 786 Score = 126 bits (316), Expect = 3e-28 Identities = 78/261 (29%), Positives = 131/261 (50%), Gaps = 7/261 (2%) Frame = +1 Query: 598 ERRPLKARDPGRFASGRHSRVYFGRYNGR-EVAIKMVSQP--HEDDALAAELERQFASEV 768 E P++ SG+ V G++ G + A+KM+ + EDD F E Sbjct: 520 EIHPMELMLMEELGSGQFGVVRRGKWRGSIDTAVKMMKEGTMSEDD---------FIEEA 570 Query: 769 ALLLRLRHHNIVSFVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVP-IQLVLQLALD 945 ++ +L+H N+V C K I+TEYM GSL YL + E + + L+L + + Sbjct: 571 KVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGLLLDMCIQ 630 Query: 946 IARGMSYLHSQGILHRDLKSENVLLGEDMSVKVADFGIS--CLESQCGSGKGFTGTYRWM 1119 +++GM+YL +HRDL + N L+G + VKVADFG++ L+ Q S G +W Sbjct: 631 VSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLARYVLDDQYTSSGGTKFPIKWA 690 Query: 1120 APEMIKEKNHTRKVDVYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCP 1296 PE++ + K DV+++G+++WEI T +P+ + + V + P SC Sbjct: 691 PPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERVQ-RGIILEKPKSCA 749 Query: 1297 VAMSHLISQCWATNPDKRPQF 1359 + ++ CW+ P++RP F Sbjct: 750 KEIYDVMKLCWSHGPEERPAF 770
>P07332:FES_HUMAN Proto-oncogene tyrosine-protein kinase Fes/Fps - Homo sapiens (Human)| Length = 822 Score = 125 bits (315), Expect = 4e-28 Identities = 79/255 (30%), Positives = 126/255 (49%), Gaps = 4/255 (1%) Frame = +1 Query: 643 GRHSRVYFGRYNGREVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSFVAAC 822 G V+ GR + + S + L +L+ +F E +L + H NIV + C Sbjct: 570 GNFGEVFSGRLRADNTLVAVKSCR---ETLPPDLKAKFLQEARILKQYSHPNIVRLIGVC 626 Query: 823 KKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGILHRDLK 1002 + I+ E + GG +L + E + ++ +LQ+ D A GM YL S+ +HRDL Sbjct: 627 TQKQPIYIVMELVQGGDFLTFL-RTEGARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLA 685 Query: 1003 SENVLLGEDMSVKVADFGISCLESQ---CGSGKGFTGTYRWMAPEMIKEKNHTRKVDVYS 1173 + N L+ E +K++DFG+S E+ SG +W APE + ++ + DV+S Sbjct: 686 ARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYGRYSSESDVWS 745 Query: 1174 FGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATNPDKR 1350 FGI+LWE + P+ ++ +Q V K R P P CP A+ L+ QCWA P +R Sbjct: 746 FGILLWETFSLGASPYPNLSNQQTREFVE-KGGRLPCPELCPDAVFRLMEQCWAYEPGQR 804 Query: 1351 PQFDDIVVVLEGYKE 1395 P F I L+ ++ Sbjct: 805 PSFSTIYQELQSIRK 819
>Q61006:MUSK_MOUSE Muscle, skeletal receptor tyrosine protein kinase precursor - Mus| musculus (Mouse) Length = 868 Score = 125 bits (314), Expect = 6e-28 Identities = 82/258 (31%), Positives = 125/258 (48%), Gaps = 26/258 (10%) Frame = +1 Query: 688 VAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSFVAACKKPPVFCIITEYMAG 867 VA+KM+ + +A+++ F E AL+ + NIV + C C++ EYMA Sbjct: 605 VAVKMLKEE-----ASADMQADFQREAALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAY 659 Query: 868 GSLRKYLHQQEPHSV--------------------PIQLVLQLAL--DIARGMSYLHSQG 981 G L ++L PH+V P+ QL + +A GM+YL + Sbjct: 660 GDLNEFLRSMSPHTVCSLSHSDLSTRARVSSPGPPPLSCAEQLCIARQVAAGMAYLSERK 719 Query: 982 ILHRDLKSENVLLGEDMSVKVADFGIS--CLESQCGSGKGFTG-TYRWMAPEMIKEKNHT 1152 +HRDL + N L+GE M VK+ADFG+S + G RWM PE I +T Sbjct: 720 FVHRDLATRNCLVGETMVVKIADFGLSRNIYSADYYKADGNDAIPIRWMPPESIFYNRYT 779 Query: 1153 RKVDVYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCW 1329 + DV+++G+VLWEI + L P+ M E+ V N P +CP+ + +L+ CW Sbjct: 780 TESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYVRDGNIL-ACPENCPLELYNLMRLCW 838 Query: 1330 ATNPDKRPQFDDIVVVLE 1383 + P RP F I +L+ Sbjct: 839 SKLPADRPSFCSIHRILQ 856
>Q8AXY6:MUSK_CHICK Muscle, skeletal receptor tyrosine protein kinase precursor - Gallus| gallus (Chicken) Length = 947 Score = 125 bits (314), Expect = 6e-28 Identities = 81/256 (31%), Positives = 127/256 (49%), Gaps = 24/256 (9%) Frame = +1 Query: 688 VAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSFVAACKKPPVFCIITEYMAG 867 VA+KM+ + +A+++ F E AL+ + NIV + C C++ EYMA Sbjct: 686 VAVKMLKEE-----ASADMQADFQREAALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAY 740 Query: 868 GSLRKYLHQQEPHSV----------------PIQLV----LQLALDIARGMSYLHSQGIL 987 G L +YL + P ++ P+ L L +A +A GM+YL + + Sbjct: 741 GDLNEYLRDRSPRNLCSLVQGGLEARACLLNPLALCCTSQLCIAKQVAAGMAYLSERKFV 800 Query: 988 HRDLKSENVLLGEDMSVKVADFGIS---CLESQCGSGKGFTGTYRWMAPEMIKEKNHTRK 1158 HRDL + N L+GE+M VK+ADFG+S + + RWM PE I +T + Sbjct: 801 HRDLATRNCLVGENMVVKIADFGLSRNMYSADYYKANENDAIPIRWMPPESIFYNRYTTE 860 Query: 1159 VDVYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWAT 1335 DV+++G+VLWEI + + P+ M E+ V N P +CP+ + +L+ CW+ Sbjct: 861 SDVWAYGVVLWEIFSYGMQPYYGMAHEEVIYYVRDGNIL-SCPDNCPLELYNLMRLCWSK 919 Query: 1336 NPDKRPQFDDIVVVLE 1383 P RP F I +LE Sbjct: 920 LPADRPSFASIHRILE 935
>P16591:FER_HUMAN Proto-oncogene tyrosine-protein kinase FER - Homo sapiens (Human)| Length = 822 Score = 125 bits (314), Expect = 6e-28 Identities = 81/248 (32%), Positives = 128/248 (51%), Gaps = 6/248 (2%) Frame = +1 Query: 643 GRHSRVYFGRYNGR-EVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSFVAA 819 G VY G + VA+K + L EL+ +F E +L + H NIV + Sbjct: 572 GNFGEVYKGTLKDKTSVAVKTCKED-----LPQELKIKFLQEAKILKQYDHPNIVKLIGV 626 Query: 820 CKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGILHRDL 999 C + II E ++GG +L +++ QLV + +LD A GM YL S+ +HRDL Sbjct: 627 CTQRQPVYIIMELVSGGDFLTFLRRKKDELKLKQLV-KFSLDAAAGMLYLESKNCIHRDL 685 Query: 1000 KSENVLLGEDMSVKVADFGISCLESQCGSGKGFTG----TYRWMAPEMIKEKNHTRKVDV 1167 + N L+GE+ +K++DFG+S E G +G +W APE + ++ + DV Sbjct: 686 AARNCLVGENNVLKISDFGMSRQED--GGVYSSSGLKQIPIKWTAPEALNYGRYSSESDV 743 Query: 1168 YSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATNPD 1344 +SFGI+LWE + + P+ MT +QA V + R P CP +S ++ +CW P+ Sbjct: 744 WSFGILLWETFSLGVCPYPGMTNQQAREQVE-RGYRMSAPQHCPEDISKIMMKCWDYKPE 802 Query: 1345 KRPQFDDI 1368 RP+F ++ Sbjct: 803 NRPKFSEL 810
>O13146:EPHA3_DANRE Ephrin type-A receptor 3 precursor - Danio rerio (Zebrafish)| (Brachydanio rerio) Length = 981 Score = 125 bits (314), Expect = 6e-28 Identities = 81/238 (34%), Positives = 120/238 (50%), Gaps = 5/238 (2%) Frame = +1 Query: 685 EVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSFVAACKKPPVFCIITEYMA 864 +VAIK + + + R F SE +++ + H NI+ + I+TEYM Sbjct: 654 QVAIKSLKAGYSEHQ-----RRDFLSEASIMGQFDHPNIIRLEGVVTRCKPVMIVTEYME 708 Query: 865 GGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGILHRDLKSENVLLGEDMSVKV 1044 GSL +L + + IQL L + IA GM YL +HRDL + N+L+ ++ KV Sbjct: 709 NGSLDTFLKKHDGQFTVIQL-LGMLRGIAAGMQYLSEMNYVHRDLAARNILVNRNLVCKV 767 Query: 1045 ADFGIS-CLESQ---CGSGKGFTGTYRWMAPEMIKEKNHTRKVDVYSFGIVLWEILT-AL 1209 +DFG+S LE + +G RW APE I + T DV+S+GIV+WE+++ Sbjct: 768 SDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAITYRKFTSASDVWSYGIVMWEVISYGE 827 Query: 1210 VPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATNPDKRPQFDDIVVVLE 1383 P+ EM+ Q I + R P P CPV + L+ CW N RP+F IV L+ Sbjct: 828 RPYWEMS-NQDVIKAVDEGYRLPAPMDCPVVLHQLMLDCWEKNRSDRPKFGQIVNTLD 884
>P21709:EPHA1_HUMAN Ephrin type-A receptor 1 precursor - Homo sapiens (Human)| Length = 976 Score = 125 bits (314), Expect = 6e-28 Identities = 76/220 (34%), Positives = 114/220 (51%), Gaps = 10/220 (4%) Frame = +1 Query: 754 FASEVALLLRLRHHNIVSFVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQ 933 F E ++ + H +I+ K IITE+M G+L +L ++E VP QLV Sbjct: 670 FLREATIMGQFSHPHILHLEGVVTKRKPIMIITEFMENGALDAFLREREDQLVPGQLVAM 729 Query: 934 LALDIARGMSYLHSQGILHRDLKSENVLLGEDMSVKVADFGISCLESQCGSGKGFTGTY- 1110 L IA GM+YL + +HRDL + N+L+ +++ KV+DFG++ L F GTY Sbjct: 730 LQ-GIASGMNYLSNHNYVHRDLAARNILVNQNLCCKVSDFGLTRLLDD------FDGTYE 782 Query: 1111 --------RWMAPEMIKEKNHTRKVDVYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALK 1263 RW APE I + T DV+SFGIV+WE+L+ P+ EM+ ++ ++ Sbjct: 783 TQGGKIPIRWTAPEAIAHRIFTTASDVWSFGIVMWEVLSFGDKPYGEMSNQEVMKSIE-D 841 Query: 1264 NARPPLPASCPVAMSHLISQCWATNPDKRPQFDDIVVVLE 1383 R P P CP + L+ CWA + +RP F + LE Sbjct: 842 GYRLPPPVDCPAPLYELMKNCWAYDRARRPHFQKLQAHLE 881
>O73798:IGF1R_XENLA Insulin-like growth factor 1 receptor precursor - Xenopus laevis| (African clawed frog) Length = 1358 Score = 125 bits (313), Expect = 8e-28 Identities = 83/262 (31%), Positives = 135/262 (51%), Gaps = 14/262 (5%) Frame = +1 Query: 685 EVAIKMVSQPHEDDALAAELER-QFASEVALLLRLRHHNIVSFVAACKKPPVFCIITEYM 861 +VAIK V++ A+ ER +F +E +++ H++V + + +I E M Sbjct: 1025 KVAIKTVNEA------ASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELM 1078 Query: 862 AGGSLRKYLHQQEPHSVP--------IQLVLQLALDIARGMSYLHSQGILHRDLKSENVL 1017 G L+ YL P + ++ ++Q+A +IA GMSYL++ +HRDL + N + Sbjct: 1079 TRGDLKSYLRSLRPDTESNSGQPTPSLKKMIQMAGEIADGMSYLNANKFVHRDLAARNCM 1138 Query: 1018 LGEDMSVKVADFGISC----LESQCGSGKGFTGTYRWMAPEMIKEKNHTRKVDVYSFGIV 1185 + ED +VK+ DFG++ + GKG RWM+PE +K+ T DV+SFG+V Sbjct: 1139 VTEDFTVKIGDFGMTRDIYETDYYRKGGKGLL-PVRWMSPESLKDGVFTTNSDVWSFGVV 1197 Query: 1186 LWEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATNPDKRPQFD 1362 LWEI T A P+ M+ EQ + ++ P +CP + L+ CW NP RP F Sbjct: 1198 LWEIATLAEQPYQGMSNEQ-VLRFVMEGGLLEKPDNCPDMLFELMRMCWQFNPKMRPSFL 1256 Query: 1363 DIVVVLEGYKEALDNDPSFFLS 1428 +I+ ++ + + SFF S Sbjct: 1257 EIISSIKDELDPGFKEVSFFYS 1278
>Q9TTY2:FER_CANFA Proto-oncogene tyrosine-protein kinase FER - Canis familiaris (Dog)| Length = 823 Score = 125 bits (313), Expect = 8e-28 Identities = 78/248 (31%), Positives = 129/248 (52%), Gaps = 6/248 (2%) Frame = +1 Query: 643 GRHSRVYFGRYNGRE-VAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSFVAA 819 G VY G + VA+K + L EL+ +F E +L + H NIV + Sbjct: 572 GNFGEVYKGILKDKTAVAVKTCKED-----LPQELKIKFLQEAKILKQYDHPNIVKLIGV 626 Query: 820 CKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGILHRDL 999 C + II E + GG +L +++ + ++ +++ +LD A GMSYL S+ +HRDL Sbjct: 627 CTQRQPIYIIMELVPGGDFLSFLRKKKDE-IKLKQLVKFSLDAASGMSYLESKNCIHRDL 685 Query: 1000 KSENVLLGEDMSVKVADFGISCLESQCGSGKGFTG----TYRWMAPEMIKEKNHTRKVDV 1167 + N L+GE+ +K++DFG+S E G +G +W APE + ++ + DV Sbjct: 686 AARNCLVGENNVLKISDFGMSRQED--GGVYSSSGLKQIPIKWTAPEALNYGRYSSESDV 743 Query: 1168 YSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATNPD 1344 +SFGI+LWE + + P+ MT +QA V + R P CP + ++ +CW P+ Sbjct: 744 WSFGILLWETFSLGVCPYPGMTNQQATEQVE-RGYRISAPQHCPEDIFKIMMKCWDYKPE 802 Query: 1345 KRPQFDDI 1368 RP+F ++ Sbjct: 803 NRPKFSEL 810
>Q07494:EPHB1_CHICK Ephrin type-B receptor 1 - Gallus gallus (Chicken)| Length = 984 Score = 125 bits (313), Expect = 8e-28 Identities = 85/260 (32%), Positives = 130/260 (50%), Gaps = 12/260 (4%) Frame = +1 Query: 640 SGRHSRVYFGRYN---GRE--VAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIV 804 +G VY GR RE VAIK + + + + R F SE +++ + H NI+ Sbjct: 627 AGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSE-----KQRRDFLSEASIMGQFDHPNII 681 Query: 805 SFVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGI 984 K IITE+M G+L +L Q + IQLV L IA GM YL Sbjct: 682 RLEGVVTKSRPVMIITEFMENGALDSFLRQNDGQFTVIQLVGMLR-GIAAGMKYLAEMNY 740 Query: 985 LHRDLKSENVLLGEDMSVKVADFGISCLESQCGSGKGFTGT------YRWMAPEMIKEKN 1146 +HRDL + N+L+ ++ KV+DFG+S S +T + RW APE I + Sbjct: 741 VHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTAPEAIAYRK 800 Query: 1147 HTRKVDVYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQ 1323 T DV+S+GIV+WE+++ P+ +M+ + A+ ++ R P P CP A+ L+ Sbjct: 801 FTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIE-QDYRLPPPMDCPAALHQLMLD 859 Query: 1324 CWATNPDKRPQFDDIVVVLE 1383 CW + + RP+ +IV L+ Sbjct: 860 CWQKDRNTRPRLAEIVNTLD 879
>Q91694:EPA4B_XENLA Ephrin type-A receptor 4-B precursor - Xenopus laevis (African clawed| frog) Length = 985 Score = 125 bits (313), Expect = 8e-28 Identities = 82/237 (34%), Positives = 121/237 (51%), Gaps = 5/237 (2%) Frame = +1 Query: 688 VAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSFVAACKKPPVFCIITEYMAG 867 VAIK + + D + R F SE +++ + H NI+ K IITEYM Sbjct: 649 VAIKTLKAGYTD-----KQRRDFLSEASIMGQFDHPNIIHLEGVVTKCKPVMIITEYMEN 703 Query: 868 GSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGILHRDLKSENVLLGEDMSVKVA 1047 GSL +L + + IQLV L I GM YL +HRDL + N+L+ ++ KV+ Sbjct: 704 GSLDAFLRKNDGRFTVIQLVGMLR-GIGSGMKYLSDMSYVHRDLAARNILVNSNLVCKVS 762 Query: 1048 DFGIS-CLESQ---CGSGKGFTGTYRWMAPEMIKEKNHTRKVDVYSFGIVLWEILT-ALV 1212 DFG+S LE + +G RW APE I + T DV+S+GIV+WE+++ Sbjct: 763 DFGMSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGER 822 Query: 1213 PFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATNPDKRPQFDDIVVVLE 1383 P+ +M+ Q I + R P P CP+A+ L+ CW + RP+F IV +L+ Sbjct: 823 PYWDMS-NQDVIKAIEEGYRLPPPMDCPIALHQLMLDCWQKDRSDRPKFGQIVSMLD 878
>P41241:CSK_MOUSE Tyrosine-protein kinase CSK - Mus musculus (Mouse)| Length = 450 Score = 125 bits (313), Expect = 8e-28 Identities = 92/280 (32%), Positives = 139/280 (49%), Gaps = 5/280 (1%) Frame = +1 Query: 568 QDPGRRRG-ALERRPLKARDPGRFASGRHSRVYFGRYNGREVAIKMVSQPHEDDALAAEL 744 QD R G AL + LK G V G Y G +VA+K + ++DA A Sbjct: 180 QDEFYRSGWALNMKELKLLQT--IGKGEFGDVMLGDYRGNKVAVKCI----KNDATA--- 230 Query: 745 ERQFASEVALLLRLRHHNIVSFVAAC-KKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQ 921 + F +E +++ +LRH N+V + ++ I+TEYMA GSL YL + + Sbjct: 231 -QAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGD 289 Query: 922 LVLQLALDIARGMSYLHSQGILHRDLKSENVLLGEDMSVKVADFGISCLESQCGSGKGFT 1101 +L+ +LD+ M YL +HRDL + NVL+ ED KV+DFG+ ++ S T Sbjct: 290 CLLKFSLDVLEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGL----TKEASSTQDT 345 Query: 1102 G--TYRWMAPEMIKEKNHTRKVDVYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNAR 1272 G +W APE ++EK + K DV+SFGI+LWEI + VP+ + P + + K + Sbjct: 346 GKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRI-PLKDVVPRVEKGYK 404 Query: 1273 PPLPASCPVAMSHLISQCWATNPDKRPQFDDIVVVLEGYK 1392 P CP A+ ++ C + RP F + LE K Sbjct: 405 MDAPDGCPPAVYDVMKNCSHLDAATRPTFLQLREQLEHIK 444
>Q15569:TESK1_HUMAN Dual specificity testis-specific protein kinase 1 - Homo sapiens| (Human) Length = 626 Score = 124 bits (311), Expect = 1e-27 Identities = 87/267 (32%), Positives = 128/267 (47%), Gaps = 10/267 (3%) Frame = +1 Query: 631 RFASGRHSRVYFGRY--NGREVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIV 804 + +G S VY R+ +G+ + +KM P EV L+ RLRH NI+ Sbjct: 62 KIGAGFFSEVYKVRHRQSGQVMVLKMNKLPSN--------RGNTLREVQLMNRLRHPNIL 113 Query: 805 SFVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGI 984 F+ C +TEYM GG+L + L EP S P++L LALDIARG+ YLHS+G+ Sbjct: 114 RFMGVCVHQGQLHALTEYMNGGTLEQLLSSPEPLSWPVRL--HLALDIARGLRYLHSKGV 171 Query: 985 LHRDLKSENVLLGED---MSVKVADFGIS-----CLESQCGSGKGFTGTYRWMAPEMIKE 1140 HRDL S+N L+ + + V DFG++ E G+ WMAPE+++ Sbjct: 172 FHRDLTSKNCLVRREDRGFTAVVGDFGLAEKIPVYREGARKEPLAVVGSPYWMAPEVLRG 231 Query: 1141 KNHTRKVDVYSFGIVLWEILTALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLIS 1320 + + K DV++FGIVL E++ + + P + + R + CP+ L Sbjct: 232 ELYDEKADVFAFGIVLCELIARVPADPDYLPRTEDFGLDVPAFRTLVGDDCPLPFLLLAI 291 Query: 1321 QCWATNPDKRPQFDDIVVVLEGYKEAL 1401 C P R F +I LE E L Sbjct: 292 HCCNLEPSTRAPFTEITQHLEWILEQL 318
>Q60751:IGF1R_MOUSE Insulin-like growth factor 1 receptor precursor - Mus musculus| (Mouse) Length = 1373 Score = 124 bits (311), Expect = 1e-27 Identities = 84/262 (32%), Positives = 132/262 (50%), Gaps = 15/262 (5%) Frame = +1 Query: 688 VAIKMVSQPHEDDALAAELER-QFASEVALLLRLRHHNIVSFVAACKKPPVFCIITEYMA 864 VAIK V++ A+ ER +F +E +++ H++V + + +I E M Sbjct: 1031 VAIKTVNEA------ASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMT 1084 Query: 865 GGSLRKYLHQQEPHSVPIQLVL---------QLALDIARGMSYLHSQGILHRDLKSENVL 1017 G L+ YL P LVL Q+A +IA GM+YL++ +HRDL + N + Sbjct: 1085 RGDLKSYLRSLRPEVEQNNLVLIPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCM 1144 Query: 1018 LGEDMSVKVADFGISC----LESQCGSGKGFTGTYRWMAPEMIKEKNHTRKVDVYSFGIV 1185 + ED +VK+ DFG++ + GKG RWM+PE +K+ T DV+SFG+V Sbjct: 1145 VAEDFTVKIGDFGMTRDIYETDYYRKGGKGLL-PVRWMSPESLKDGVFTTHSDVWSFGVV 1203 Query: 1186 LWEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATNPDKRPQFD 1362 LWEI T A P+ ++ EQ + ++ P +CP + L+ CW NP RP F Sbjct: 1204 LWEIATLAEQPYQGLSNEQ-VLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFL 1262 Query: 1363 DIVVVLEGYKEALDNDPSFFLS 1428 +I+ ++ E + SF+ S Sbjct: 1263 EIIGSIKDEMEPSFQEVSFYYS 1284
>Q03137:EPHA4_MOUSE Ephrin type-A receptor 4 precursor - Mus musculus (Mouse)| Length = 986 Score = 124 bits (311), Expect = 1e-27 Identities = 82/237 (34%), Positives = 120/237 (50%), Gaps = 5/237 (2%) Frame = +1 Query: 688 VAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSFVAACKKPPVFCIITEYMAG 867 VAIK + + D + R F SE +++ + H NI+ K IITEYM Sbjct: 650 VAIKTLKAGYTD-----KQRRDFLSEASIMGQFDHPNIIHLEGVVTKCKPVMIITEYMEN 704 Query: 868 GSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGILHRDLKSENVLLGEDMSVKVA 1047 GSL +L + + IQLV L I GM YL +HRDL + N+L+ ++ KV+ Sbjct: 705 GSLDAFLRKNDGRFTVIQLVGMLR-GIGSGMKYLSDMSYVHRDLAARNILVNSNLVCKVS 763 Query: 1048 DFGIS-CLESQ---CGSGKGFTGTYRWMAPEMIKEKNHTRKVDVYSFGIVLWEILT-ALV 1212 DFG+S LE + +G RW APE I + T DV+S+GIV+WE+++ Sbjct: 764 DFGMSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGER 823 Query: 1213 PFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATNPDKRPQFDDIVVVLE 1383 P+ +M+ Q I + R P P CP+A+ L+ CW RP+F IV +L+ Sbjct: 824 PYWDMS-NQDVIKAIEEGYRLPPPMDCPIALHQLMLDCWQKERSDRPKFGQIVNMLD 879
>P54764:EPHA4_HUMAN Ephrin type-A receptor 4 precursor - Homo sapiens (Human)| Length = 986 Score = 124 bits (311), Expect = 1e-27 Identities = 82/237 (34%), Positives = 120/237 (50%), Gaps = 5/237 (2%) Frame = +1 Query: 688 VAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSFVAACKKPPVFCIITEYMAG 867 VAIK + + D + R F SE +++ + H NI+ K IITEYM Sbjct: 650 VAIKTLKAGYTD-----KQRRDFLSEASIMGQFDHPNIIHLEGVVTKCKPVMIITEYMEN 704 Query: 868 GSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGILHRDLKSENVLLGEDMSVKVA 1047 GSL +L + + IQLV L I GM YL +HRDL + N+L+ ++ KV+ Sbjct: 705 GSLDAFLRKNDGRFTVIQLVGMLR-GIGSGMKYLSDMSYVHRDLAARNILVNSNLVCKVS 763 Query: 1048 DFGIS-CLESQ---CGSGKGFTGTYRWMAPEMIKEKNHTRKVDVYSFGIVLWEILT-ALV 1212 DFG+S LE + +G RW APE I + T DV+S+GIV+WE+++ Sbjct: 764 DFGMSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGER 823 Query: 1213 PFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATNPDKRPQFDDIVVVLE 1383 P+ +M+ Q I + R P P CP+A+ L+ CW RP+F IV +L+ Sbjct: 824 PYWDMS-NQDVIKAIEEGYRLPPPMDCPIALHQLMLDCWQKERSDRPKFGQIVNMLD 879
>Q07496:EPHA4_CHICK Ephrin type-A receptor 4 precursor - Gallus gallus (Chicken)| Length = 986 Score = 124 bits (311), Expect = 1e-27 Identities = 82/237 (34%), Positives = 120/237 (50%), Gaps = 5/237 (2%) Frame = +1 Query: 688 VAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSFVAACKKPPVFCIITEYMAG 867 VAIK + + D + R F SE +++ + H NI+ K IITEYM Sbjct: 650 VAIKTLKAGYTD-----KQRRDFLSEASIMGQFDHPNIIHLEGVVTKCKPVMIITEYMEN 704 Query: 868 GSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGILHRDLKSENVLLGEDMSVKVA 1047 GSL +L + + IQLV L I GM YL +HRDL + N+L+ ++ KV+ Sbjct: 705 GSLDAFLRKNDGRFTVIQLVGMLR-GIGSGMKYLSDMSYVHRDLAARNILVNSNLVCKVS 763 Query: 1048 DFGIS-CLESQ---CGSGKGFTGTYRWMAPEMIKEKNHTRKVDVYSFGIVLWEILT-ALV 1212 DFG+S LE + +G RW APE I + T DV+S+GIV+WE+++ Sbjct: 764 DFGMSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGER 823 Query: 1213 PFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATNPDKRPQFDDIVVVLE 1383 P+ +M+ Q I + R P P CP+A+ L+ CW RP+F IV +L+ Sbjct: 824 PYWDMS-NQDVIKAIEEGYRLPPPMDCPIALHQLMLDCWQKERSDRPKFGQIVNMLD 879
>Q9H3Y6:SRMS_HUMAN Tyrosine-protein kinase Srms - Homo sapiens (Human)| Length = 488 Score = 124 bits (310), Expect = 2e-27 Identities = 82/263 (31%), Positives = 129/263 (49%), Gaps = 10/263 (3%) Frame = +1 Query: 601 RRPLKARDPGRFASGRH-SRVYFGRY------NGREVAIKMVSQPHEDDALAAELERQFA 759 R+ + R FA GR YFG VAIK++ A A Sbjct: 219 RQDVWERPHSEFALGRKLGEGYFGEVWEGLWLGSLPVAIKVIKS-------ANMKLTDLA 271 Query: 760 SEVALLLRLRHHNIVSFVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLA 939 E+ L LRH ++ A C I+TE M G+L+ +L E ++ + +L A Sbjct: 272 KEIQTLKGLRHERLIRLHAVCSGGEPVYIVTELMRKGNLQAFLGTPEGRALRLPPLLGFA 331 Query: 940 LDIARGMSYLHSQGILHRDLKSENVLLGEDMSVKVADFGISCL--ESQCGSGKGFTGTYR 1113 +A GMSYL Q ++HRDL + NVL+ + ++ KVADFG++ L + + Sbjct: 332 CQVAEGMSYLEEQRVVHRDLAARNVLVDDGLACKVADFGLARLLKDDIYSPSSSSKIPVK 391 Query: 1114 WMAPEMIKEKNHTRKVDVYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPPLPAS 1290 W APE + ++K DV+SFG++L E+ T P+ MT + + ++ R P PA+ Sbjct: 392 WTAPEAANYRVFSQKSDVWSFGVLLHEVFTYGQCPYEGMTNHE-TLQQIMRGYRLPRPAA 450 Query: 1291 CPVAMSHLISQCWATNPDKRPQF 1359 CP + L+ +CW ++P++RP F Sbjct: 451 CPAEVYVLMLECWRSSPEERPSF 473
>Q9PVZ4:INSR_XENLA Insulin receptor precursor - Xenopus laevis (African clawed frog)| Length = 1362 Score = 124 bits (310), Expect = 2e-27 Identities = 80/260 (30%), Positives = 134/260 (51%), Gaps = 13/260 (5%) Frame = +1 Query: 688 VAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSFVAACKKPPVFCIITEYMAG 867 VA+K V+ E +L +E F +E +++ H++V + K +I E MA Sbjct: 1043 VAVKTVN---ESASLRERIE--FLNEASVMKAFNCHHVVRLLGVVSKGQPTLVIMELMAH 1097 Query: 868 GSLRKYLHQQEPHSV--------PIQLVLQLALDIARGMSYLHSQGILHRDLKSENVLLG 1023 G L+ YL P + ++ ++Q+A +I+ GM+YL+++ +HRDL + N ++ Sbjct: 1098 GDLKSYLRSLRPDAENNPGRLAPTLKEIIQMAAEISDGMAYLNAKKFVHRDLAARNCMVA 1157 Query: 1024 EDMSVKVADFGISC----LESQCGSGKGFTGTYRWMAPEMIKEKNHTRKVDVYSFGIVLW 1191 +D +VK+ DFG++ + GKG RWM+PE +K+ T DV+SFG+VLW Sbjct: 1158 DDYAVKIGDFGMTRDIYETDYYRKGGKGLL-PVRWMSPESLKDGVFTAFSDVWSFGVVLW 1216 Query: 1192 EILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATNPDKRPQFDDI 1368 EI + A P+ ++ EQ + + P +CP + L+ CW NP RP F +I Sbjct: 1217 EITSLAEQPYQGLSNEQ-VLKFVMDGGSLDHPENCPPRLHSLMQMCWQYNPKMRPTFLEI 1275 Query: 1369 VVVLEGYKEALDNDPSFFLS 1428 + +L+ D SF+ S Sbjct: 1276 IDMLKDDLRPSFQDVSFYYS 1295
>P06213:INSR_HUMAN Insulin receptor precursor - Homo sapiens (Human)| Length = 1382 Score = 124 bits (310), Expect = 2e-27 Identities = 82/260 (31%), Positives = 134/260 (51%), Gaps = 13/260 (5%) Frame = +1 Query: 688 VAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSFVAACKKPPVFCIITEYMAG 867 VA+K V+ E +L +E F +E +++ H++V + K ++ E MA Sbjct: 1054 VAVKTVN---ESASLRERIE--FLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAH 1108 Query: 868 GSLRKYLHQQEPHSV--------PIQLVLQLALDIARGMSYLHSQGILHRDLKSENVLLG 1023 G L+ YL P + +Q ++Q+A +IA GM+YL+++ +HRDL + N ++ Sbjct: 1109 GDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVA 1168 Query: 1024 EDMSVKVADFGISC----LESQCGSGKGFTGTYRWMAPEMIKEKNHTRKVDVYSFGIVLW 1191 D +VK+ DFG++ + GKG RWMAPE +K+ T D++SFG+VLW Sbjct: 1169 HDFTVKIGDFGMTRDIYETDYYRKGGKGLL-PVRWMAPESLKDGVFTTSSDMWSFGVVLW 1227 Query: 1192 EILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATNPDKRPQFDDI 1368 EI + A P+ ++ EQ + + P +CP ++ L+ CW NP RP F +I Sbjct: 1228 EITSLAEQPYQGLSNEQ-VLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEI 1286 Query: 1369 VVVLEGYKEALDNDPSFFLS 1428 V +L+ + SFF S Sbjct: 1287 VNLLKDDLHPSFPEVSFFHS 1306
>Q05688:IGF1R_BOVIN Insulin-like growth factor 1 receptor precursor - Bos taurus (Bovine)| Length = 640 Score = 124 bits (310), Expect = 2e-27 Identities = 82/261 (31%), Positives = 133/261 (50%), Gaps = 14/261 (5%) Frame = +1 Query: 688 VAIKMVSQPHEDDALAAELER-QFASEVALLLRLRHHNIVSFVAACKKPPVFCIITEYMA 864 VAIK V++ A+ ER +F +E +++ H++V + + +I E M Sbjct: 303 VAIKTVNEA------ASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMT 356 Query: 865 GGSLRKYLHQQEPHSV--------PIQLVLQLALDIARGMSYLHSQGILHRDLKSENVLL 1020 G L+ YL P + ++Q+A +IA GM+YL++ +HRDL + N ++ Sbjct: 357 RGDLKSYLRSLRPEMENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMV 416 Query: 1021 GEDMSVKVADFGISC----LESQCGSGKGFTGTYRWMAPEMIKEKNHTRKVDVYSFGIVL 1188 ED +VK+ DFG++ + GKG RWM+PE +K+ T DV+SFG+VL Sbjct: 417 AEDFTVKIGDFGMTRDIYETDYYRKGGKGLL-PVRWMSPESLKDGVFTTHSDVWSFGVVL 475 Query: 1189 WEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATNPDKRPQFDD 1365 WEI T A P+ ++ EQ + ++ P +CP + L+ CW NP RP F + Sbjct: 476 WEIATLAEQPYQGLSNEQ-VLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLE 534 Query: 1366 IVVVLEGYKEALDNDPSFFLS 1428 I+ ++ EA + SF+ S Sbjct: 535 IISSVKDEMEAGFREVSFYYS 555
>P14238:FES_FELCA Proto-oncogene tyrosine-protein kinase Fes/Fps - Felis silvestris| catus (Cat) Length = 820 Score = 124 bits (310), Expect = 2e-27 Identities = 78/255 (30%), Positives = 126/255 (49%), Gaps = 4/255 (1%) Frame = +1 Query: 643 GRHSRVYFGRYNGREVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSFVAAC 822 G V+ GR + + S + L +++ +F E +L + H NIV + C Sbjct: 568 GNFGEVFSGRLRADNTLVAVKSCR---ETLPPDIKAKFLQEAKILKQYSHPNIVRLIGVC 624 Query: 823 KKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGILHRDLK 1002 + I+ E + GG +L + E + ++ +LQ+ D A GM YL S+ +HRDL Sbjct: 625 TQKQPIYIVMELVQGGDFLTFL-RTEGARLRMKTLLQMVGDAAAGMEYLESKCCIHRDLA 683 Query: 1003 SENVLLGEDMSVKVADFGISCLESQ---CGSGKGFTGTYRWMAPEMIKEKNHTRKVDVYS 1173 + N L+ E +K++DFG+S E+ SG +W APE + ++ + DV+S Sbjct: 684 ARNCLVTEKNVLKISDFGMSREEADGIYAASGGLRQVPVKWTAPEALNYGRYSSESDVWS 743 Query: 1174 FGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATNPDKR 1350 FGI+LWE + P+ ++ +Q V K R P P CP A+ L+ QCWA P +R Sbjct: 744 FGILLWETFSLGASPYPNLSNQQTREFVE-KGGRLPCPELCPDAVFRLMEQCWAYEPGQR 802 Query: 1351 PQFDDIVVVLEGYKE 1395 P F I L+ ++ Sbjct: 803 PSFSAIYQELQSIRK 817
>Q91845:EPA4A_XENLA Ephrin type-A receptor 4-A precursor - Xenopus laevis (African clawed| frog) Length = 986 Score = 124 bits (310), Expect = 2e-27 Identities = 81/237 (34%), Positives = 120/237 (50%), Gaps = 5/237 (2%) Frame = +1 Query: 688 VAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSFVAACKKPPVFCIITEYMAG 867 VAIK + + D + R F SE +++ + H NI+ K IITEYM Sbjct: 649 VAIKTLKAGYTD-----KQRRDFLSEASIMGQFDHPNIIHLEGVVTKCKPVMIITEYMEN 703 Query: 868 GSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGILHRDLKSENVLLGEDMSVKVA 1047 GSL +L + + IQLV + I GM YL +HRDL + N+L+ ++ KV+ Sbjct: 704 GSLDAFLRKNDGRFTVIQLV-GILRGIGSGMKYLSDMSYVHRDLAARNILVNSNLVCKVS 762 Query: 1048 DFGIS-CLESQ---CGSGKGFTGTYRWMAPEMIKEKNHTRKVDVYSFGIVLWEILT-ALV 1212 DFG+S LE + +G RW APE I + T DV+S+GIV+WE+++ Sbjct: 763 DFGMSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGER 822 Query: 1213 PFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATNPDKRPQFDDIVVVLE 1383 P+ +M+ Q I + R P P CP+A+ L+ CW RP+F IV +L+ Sbjct: 823 PYWDMS-NQDVIKAIEEGYRLPPPMDCPIALHQLMLDCWQKERSDRPKFGQIVSMLD 878
>P24062:IGF1R_RAT Insulin-like growth factor 1 receptor precursor - Rattus norvegicus| (Rat) Length = 1370 Score = 123 bits (309), Expect = 2e-27 Identities = 83/261 (31%), Positives = 134/261 (51%), Gaps = 14/261 (5%) Frame = +1 Query: 688 VAIKMVSQPHEDDALAAELER-QFASEVALLLRLRHHNIVSFVAACKKPPVFCIITEYMA 864 VAIK V++ A+ ER +F +E +++ H++V + + +I E M Sbjct: 1031 VAIKTVNEA------ASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMT 1084 Query: 865 GGSLRKYLHQQEPHS------VPIQL--VLQLALDIARGMSYLHSQGILHRDLKSENVLL 1020 G L+ YL P +P L ++Q+A +IA GM+YL++ +HRDL + N ++ Sbjct: 1085 RGDLKSYLRSLRPEVENNLVLIPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMV 1144 Query: 1021 GEDMSVKVADFGISC----LESQCGSGKGFTGTYRWMAPEMIKEKNHTRKVDVYSFGIVL 1188 ED +VK+ DFG++ + GKG RWM+PE +K+ T DV+SFG+VL Sbjct: 1145 AEDFTVKIGDFGMTRDIYETDYYRKGGKGLL-PVRWMSPESLKDGVFTTHSDVWSFGVVL 1203 Query: 1189 WEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATNPDKRPQFDD 1365 WEI T A P+ ++ EQ + ++ P +CP + L+ CW NP RP F + Sbjct: 1204 WEIATLAEQPYQGLSNEQ-VLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLE 1262 Query: 1366 IVVVLEGYKEALDNDPSFFLS 1428 I+ ++ E + SF+ S Sbjct: 1263 IIGSIKDEMEPSFQEVSFYYS 1283
>Q63572:TESK1_RAT Dual specificity testis-specific protein kinase 1 - Rattus norvegicus| (Rat) Length = 628 Score = 123 bits (308), Expect = 3e-27 Identities = 85/267 (31%), Positives = 129/267 (48%), Gaps = 10/267 (3%) Frame = +1 Query: 631 RFASGRHSRVYFGRY--NGREVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIV 804 + +G S VY R+ +G+ + +KM P EV L+ RLRH NI+ Sbjct: 57 KIGAGFFSEVYKVRHRQSGQVMVLKMNKLPSN--------RSNTLREVQLMNRLRHPNIL 108 Query: 805 SFVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGI 984 F+ C +TEYM GG+L + L EP S P++L LALDIA+G+ YLH++G+ Sbjct: 109 RFMGVCVHQGQLHALTEYMNGGTLEQLLSSPEPLSWPVRL--HLALDIAQGLRYLHAKGV 166 Query: 985 LHRDLKSENVLLGED---MSVKVADFGIS-----CLESQCGSGKGFTGTYRWMAPEMIKE 1140 HRDL S+N L+ + + V DFG++ E G+ WMAPE+++ Sbjct: 167 FHRDLTSKNCLVRREDGGFTAVVGDFGLAEKIPVYREGARKEPLAVVGSPYWMAPEVLRG 226 Query: 1141 KNHTRKVDVYSFGIVLWEILTALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLIS 1320 + + K DV++FGIVL E++ + + P + + R + CP+ L Sbjct: 227 ELYDEKADVFAFGIVLCELIARVPADPDYLPRTEDFGLDVPAFRTLVGNDCPLPFLLLAI 286 Query: 1321 QCWATNPDKRPQFDDIVVVLEGYKEAL 1401 C + P R F +I LE E L Sbjct: 287 HCCSMEPSARAPFTEITQHLEQILEQL 313
>Q25410:MIPR_LYMST Putative molluscan insulin-related peptide(s) receptor precursor -| Lymnaea stagnalis (Great pond snail) Length = 1607 Score = 123 bits (308), Expect = 3e-27 Identities = 82/260 (31%), Positives = 133/260 (51%), Gaps = 13/260 (5%) Frame = +1 Query: 688 VAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSFVAACKKPPVFCIITEYMAG 867 VA+K V+ D + R+F E + H++V + +I E MA Sbjct: 1069 VAVKTVN-----DRASFSDRREFLKEATTMKEFHCHHVVKLLGVVSTGQPALVIMELMAL 1123 Query: 868 GSLRKYLH-----QQEPHSVPIQL--VLQLALDIARGMSYLHSQGILHRDLKSENVLLGE 1026 G L+ YL + P +P L +LQ+A +IA GM+YL + +HRDL + N ++ E Sbjct: 1124 GDLKNYLRGHRPDEDHPGVMPPHLLDILQMAGEIADGMAYLADKKFVHRDLAARNCMVSE 1183 Query: 1027 DMSVKVADFGISC----LESQCGSGKGFTGTYRWMAPEMIKEKNHTRKVDVYSFGIVLWE 1194 + +VK+ DFG++ + GKG RWMAPE +K+ T DV+S+G+V+WE Sbjct: 1184 ERTVKIGDFGMTRDIYETDYYRKGGKGML-PVRWMAPESLKDGVFTSLSDVWSYGVVMWE 1242 Query: 1195 ILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATNPDKRPQFDDIV 1371 ++T A P+ ++ E+ ++ LP +CP M++L+ CWA P++RP F I+ Sbjct: 1243 MVTLAAQPYQGLSNEEVVKFIS-DGYIMELPENCPNEMAYLMQHCWAKKPNQRPTFKAII 1301 Query: 1372 -VVLEGYKEALDNDPSFFLS 1428 +L K + + FF S Sbjct: 1302 EYLLPKLKPSFEKVSYFFTS 1321
>P16879:FES_MOUSE Proto-oncogene tyrosine-protein kinase Fes/Fps - Mus musculus (Mouse)| Length = 820 Score = 123 bits (308), Expect = 3e-27 Identities = 80/256 (31%), Positives = 126/256 (49%), Gaps = 5/256 (1%) Frame = +1 Query: 643 GRHSRVYFGRYNGREVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSFVAAC 822 G V+ GR + + S + L +L+ +F E +L + H NIV + C Sbjct: 568 GNFGEVFSGRLRADNTPVAVKSCR---ETLPPDLKAKFLQEARILKQYNHPNIVRLIGVC 624 Query: 823 KKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGILHRDLK 1002 + I+ E + GG +L + E + ++ +LQ+ D A GM YL S+ +HRDL Sbjct: 625 TQKQPIYIVMELVQGGDFLTFL-RTEGARLRVKTLLQMMGDAAAGMEYLESKCCIHRDLA 683 Query: 1003 SENVLLGEDMSVKVADFGISCLESQCGSGKGFTG----TYRWMAPEMIKEKNHTRKVDVY 1170 + N L+ E +K++DFG+S E+ G +G +W APE + ++ + DV+ Sbjct: 684 ARNCLVTEKNVLKISDFGMSREEAD-GIYAACSGLRQVPVKWTAPEALNYGRYSSESDVW 742 Query: 1171 SFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATNPDK 1347 SFGI+LWE + P+ +T +Q V K R P P CP A+ L+ QCWA P + Sbjct: 743 SFGILLWETFSLGASPYPNLTNQQTREFVE-KGHRLPCPELCPDAVFRLMEQCWAYEPGQ 801 Query: 1348 RPQFDDIVVVLEGYKE 1395 RP F I L ++ Sbjct: 802 RPSFSIICQELHSIRK 817
>Q9Z139:ROR1_MOUSE Tyrosine-protein kinase transmembrane receptor ROR1 precursor - Mus| musculus (Mouse) Length = 937 Score = 122 bits (307), Expect = 4e-27 Identities = 78/234 (33%), Positives = 116/234 (49%), Gaps = 20/234 (8%) Frame = +1 Query: 751 QFASEVALLLRLRHHNIVSFVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHS------- 909 +F E +L+ L H NIV + A + C++ EYM G L ++L + PHS Sbjct: 519 EFQQEASLMAELHHPNIVCLLGAVTQEQPVCMLFEYMNQGDLHEFLIMRSPHSDVGCSSD 578 Query: 910 ----VPIQL----VLQLALDIARGMSYLHSQGILHRDLKSENVLLGEDMSVKVADFGIS- 1062 V L L +A+ IA GM YL S +H+DL + N+L+GE + VK++D G+S Sbjct: 579 EDGTVKSSLDHGDFLHIAIQIAAGMEYLSSHFFVHKDLAARNILIGEQLHVKISDLGLSR 638 Query: 1063 ---CLESQCGSGKGFTGTYRWMAPEMIKEKNHTRKVDVYSFGIVLWEILT-ALVPFSEMT 1230 + K + RWM PE I + D++SFG+VLWEI + L P+ + Sbjct: 639 EIYSADYYRVQSKS-SLPIRWMPPEAIMYGKFSSDSDIWSFGVVLWEIFSFGLQPYYGFS 697 Query: 1231 PEQAAIAVALKNARPPLPASCPVAMSHLISQCWATNPDKRPQFDDIVVVLEGYK 1392 Q I + K P CP M L+++CW P +RP+F DI V L ++ Sbjct: 698 -NQEVIEMVRKRQLLPCSEDCPPRMYSLMTECWNEIPSRRPRFKDIHVRLRSWE 750
>P00541:FPS_AVISP Tyrosine-protein kinase transforming protein Fps - Avian sarcoma| virus (strain PRCII) Length = 533 Score = 122 bits (307), Expect = 4e-27 Identities = 72/247 (29%), Positives = 124/247 (50%), Gaps = 4/247 (1%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGREVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSF 810 R G V+ GR + + S + L EL+ +F E +L + H NIV Sbjct: 277 RIGRGNFGEVFSGRLRADNTPVAVKSCR---ETLPPELKAKFLQEARILKQYNHPNIVRL 333 Query: 811 VAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGILH 990 + C + I+ E + GG +L + PH + ++ ++++ + A GM YL S+ +H Sbjct: 334 IGVCTQKQPIYIVMELVQGGDFLSFLRSKGPH-LKMKELIKMMENAAAGMEYLESKHCIH 392 Query: 991 RDLKSENVLLGEDMSVKVADFGISCLESQ---CGSGKGFTGTYRWMAPEMIKEKNHTRKV 1161 RDL + N L+ E ++K++DFG+S E +G +W APE + ++ + Sbjct: 393 RDLAARNCLVTEKNTLKISDFGMSRQEEDGVYASTGGMKQIPVKWTAPEALNYGRYSSES 452 Query: 1162 DVYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATN 1338 DV+SFGI+LWE + VP++ ++ +Q A+ + R P CP + L+ +CW + Sbjct: 453 DVWSFGILLWEAFSLGAVPYANLSNQQTREAIE-QGVRLEPPEQCPEDVYRLMQRCWEYD 511 Query: 1339 PDKRPQF 1359 P +RP F Sbjct: 512 PRRRPSF 518
>Q498D6:FGFR4_RAT Fibroblast growth factor receptor 4 precursor - Rattus norvegicus| (Rat) Length = 800 Score = 122 bits (307), Expect = 4e-27 Identities = 77/250 (30%), Positives = 124/250 (49%), Gaps = 18/250 (7%) Frame = +1 Query: 688 VAIKMVSQPHEDDALAAELERQFASEVALLLRL-RHHNIVSFVAACKKPPVFCIITEYMA 864 VA+KM+ D LA SE+ ++ + RH NI++ + C + +I EY A Sbjct: 498 VAVKMLKDNASDKDLA-----DLISEMEMMKLIGRHKNIINLLGVCTQEGPLYVIVEYAA 552 Query: 865 GGSLRKYLHQQEPHSVPIQ--------------LVLQLALDIARGMSYLHSQGILHRDLK 1002 G+LR++L + P + ++ A +ARGM YL S+ +HRDL Sbjct: 553 KGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPALVSCAYQVARGMQYLESRKCIHRDLA 612 Query: 1003 SENVLLGEDMSVKVADFGISCLESQCGSGKGFTG---TYRWMAPEMIKEKNHTRKVDVYS 1173 + NVL+ ED +K+ADFG++ K + +WMAPE + ++ +T + DV+S Sbjct: 613 ARNVLVTEDDVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWS 672 Query: 1174 FGIVLWEILTALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATNPDKRP 1353 FGI+LWEI T P + ++ + R P +CP + L+ +CW P +RP Sbjct: 673 FGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMERPPNCPSELYGLMRECWHAAPSQRP 732 Query: 1354 QFDDIVVVLE 1383 F +V L+ Sbjct: 733 TFKQLVEALD 742
>P29322:EPHA8_HUMAN Ephrin type-A receptor 8 precursor - Homo sapiens (Human)| Length = 1005 Score = 122 bits (307), Expect = 4e-27 Identities = 87/258 (33%), Positives = 128/258 (49%), Gaps = 10/258 (3%) Frame = +1 Query: 640 SGRHSRVYFGRYN--GRE---VAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIV 804 SG V +GR G+ VAIK + + + R F SE +++ + H NI+ Sbjct: 643 SGDSGEVCYGRLRVPGQRDVPVAIKALKAGYTE-----RQRRDFLSEASIMGQFDHPNII 697 Query: 805 SFVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGI 984 + + I+TEYM GSL +L + +QLV L + GM YL G Sbjct: 698 RLEGVVTRGRLAMIVTEYMENGSLDTFLRTHDGQFTIMQLVGMLR-GVGAGMRYLSDLGY 756 Query: 985 LHRDLKSENVLLGEDMSVKVADFGIS-CLESQCGSGKGFTG---TYRWMAPEMIKEKNHT 1152 +HRDL + NVL+ ++ KV+DFG+S LE + TG RW APE I + + Sbjct: 757 VHRDLAARNVLVDSNLVCKVSDFGLSRVLEDDPDAAYTTTGGKIPIRWTAPEAIAFRTFS 816 Query: 1153 RKVDVYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCW 1329 DV+SFG+V+WE+L P+ MT + I+ + R P P CP A+ L+ CW Sbjct: 817 SASDVWSFGVVMWEVLAYGERPYWNMT-NRDVISSVEEGYRLPAPMGCPHALHQLMLDCW 875 Query: 1330 ATNPDKRPQFDDIVVVLE 1383 + +RP+F IV VL+ Sbjct: 876 HKDRAQRPRFSQIVSVLD 893
>Q60750:EPHA1_MOUSE Ephrin type-A receptor 1 precursor - Mus musculus (Mouse)| Length = 977 Score = 122 bits (307), Expect = 4e-27 Identities = 78/230 (33%), Positives = 117/230 (50%), Gaps = 10/230 (4%) Frame = +1 Query: 754 FASEVALLLRLRHHNIVSFVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQ 933 F E ++ + H +I+ K IITE+M G+L +L ++E P QLV Sbjct: 671 FLREATIMGQFNHPHILRLEGVITKRKPIMIITEFMENGALDAFLKEREDQLAPGQLVAM 730 Query: 934 LALDIARGMSYLHSQGILHRDLKSENVLLGEDMSVKVADFGISCLESQCGSGKGFTGTY- 1110 L L IA GM+ L +HRDL + N+L+ +++ KV+DFG++ L F GTY Sbjct: 731 L-LGIASGMNCLSGHNYVHRDLAARNILVNQNLCCKVSDFGLTRLLDD------FDGTYE 783 Query: 1111 --------RWMAPEMIKEKNHTRKVDVYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALK 1263 RW APE I + T DV+SFGIV+WE+L+ P+ EM+ ++ ++ Sbjct: 784 TQGGKIPIRWTAPEAIAHRIFTTASDVWSFGIVMWEVLSFGDKPYGEMSNQEVMKSIE-D 842 Query: 1264 NARPPLPASCPVAMSHLISQCWATNPDKRPQFDDIVVVLEGYKEALDNDP 1413 R P P CP + L+ CWA + +RP F + L+ + E L DP Sbjct: 843 GYRLPPPVDCPAPLYELMKNCWAYDRARRPHF----LQLQAHLEQLLTDP 888
>P00528:SRC64_DROME Tyrosine-protein kinase Src64B - Drosophila melanogaster (Fruit fly)| Length = 552 Score = 122 bits (306), Expect = 5e-27 Identities = 76/250 (30%), Positives = 129/250 (51%), Gaps = 6/250 (2%) Frame = +1 Query: 631 RFASGRHSRVYFGRY-NGREVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVS 807 + G V++G++ N +VA+K + + A F E A++ + RH+ +V+ Sbjct: 289 KLGRGNFGEVFYGKWRNSIDVAVKTLREGTMSTAA-------FLQEAAIMKKFRHNRLVA 341 Query: 808 FVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGIL 987 A C + I+ EYM+ GSL +L + + + + ++ +A +A GM YL S+ ++ Sbjct: 342 LYAVCSQEEPIYIVQEYMSKGSLLDFLREGDGRYLHFEDLIYIATQVASGMEYLESKQLI 401 Query: 988 HRDLKSENVLLGEDMSVKVADFGIS--CLESQCGSGKGFTGTYRWMAPEMIKEKNHTRKV 1161 HRDL + NVL+GE+ K+ DFG++ + + +G +W APE I + K Sbjct: 402 HRDLAARNVLIGENNVAKICDFGLARVIADDEYCPKQGSRFPVKWTAPEAIIYGKFSIKS 461 Query: 1162 DVYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPPLPAS--CPVAMSHLISQCWA 1332 DV+S+GI+L E+ T VP+ M + I + R P P + P + L+ QCW Sbjct: 462 DVWSYGILLMELFTYGQVPYPGMHSRE-VIENIERGFRMPKPTNHYFPDNIYQLLLQCWD 520 Query: 1333 TNPDKRPQFD 1362 P+KRP F+ Sbjct: 521 AVPEKRPTFE 530
>P53667:LIMK1_HUMAN LIM domain kinase 1 - Homo sapiens (Human)| Length = 647 Score = 122 bits (306), Expect = 5e-27 Identities = 84/237 (35%), Positives = 120/237 (50%), Gaps = 16/237 (6%) Frame = +1 Query: 739 ELERQFASEVALLLRLRHHNIVSFVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPI 918 E +R F EV ++ L H N++ F+ K ITEY+ GG+LR + + P Sbjct: 376 ETQRTFLKEVKVMRCLEHPNVLKFIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQ-YPW 434 Query: 919 QLVLQLALDIARGMSYLHSQGILHRDLKSENVLLGEDMSVKVADFGISCL---ESQCGSG 1089 + A DIA GM+YLHS I+HRDL S N L+ E+ +V VADFG++ L E G Sbjct: 435 SQRVSFAKDIASGMAYLHSMNIIHRDLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEG 494 Query: 1090 ----------KGFT--GTYRWMAPEMIKEKNHTRKVDVYSFGIVLWEILTALVPFSEMTP 1233 K +T G WMAPEMI +++ KVDV+SFGIVL EI+ + + P Sbjct: 495 LRSLKKPDRKKRYTVVGNPYWMAPEMINGRSYDEKVDVFSFGIVLCEIIGRVNADPDYLP 554 Query: 1234 EQAAIAVALKNARPP-LPASCPVAMSHLISQCWATNPDKRPQFDDIVVVLEGYKEAL 1401 + ++ P +CP + + +C +P+KRP F V LE + E L Sbjct: 555 RTMDFGLNVRGFLDRYCPPNCPPSFFPITVRCCDLDPEKRPSF----VKLEHWLETL 607
>P00543:FES_FSVST Tyrosine-protein kinase transforming protein Fes - Feline sarcoma| virus (strain Snyder-Theilen) Length = 477 Score = 122 bits (306), Expect = 5e-27 Identities = 77/255 (30%), Positives = 125/255 (49%), Gaps = 4/255 (1%) Frame = +1 Query: 643 GRHSRVYFGRYNGREVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSFVAAC 822 G V+ GR + + S + L +++ +F E +L + H NIV + C Sbjct: 225 GNFGEVFSGRLRADNTLVAVKSCR---ETLPPDIKAKFLQEAKILKQYSHPNIVRLIGVC 281 Query: 823 KKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGILHRDLK 1002 + I+ E + GG +L + E + ++ +LQ+ D A GM YL S+ +HRDL Sbjct: 282 TQKQPIYIVMELVQGGDFLTFL-RTEGARLRMKTLLQMVGDAAAGMEYLESKCCIHRDLA 340 Query: 1003 SENVLLGEDMSVKVADFGISCLESQ---CGSGKGFTGTYRWMAPEMIKEKNHTRKVDVYS 1173 + N L+ E +K++DFG+S E+ SG +W APE + ++ + DV+S Sbjct: 341 ARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRLVPVKWTAPEALNYGRYSSESDVWS 400 Query: 1174 FGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATNPDKR 1350 FGI+LWE + P+ ++ +Q V K R P P CP A+ L+ QCWA P +R Sbjct: 401 FGILLWETFSLGASPYPNLSNQQTREFVE-KGGRLPCPELCPDAVFRLMEQCWAYEPGQR 459 Query: 1351 PQFDDIVVVLEGYKE 1395 P F L+ ++ Sbjct: 460 PSFSAFYQELQSIRK 474
>O70146:TESK1_MOUSE Dual specificity testis-specific protein kinase 1 - Mus musculus| (Mouse) Length = 627 Score = 122 bits (305), Expect = 6e-27 Identities = 83/261 (31%), Positives = 127/261 (48%), Gaps = 10/261 (3%) Frame = +1 Query: 631 RFASGRHSRVYFGRY--NGREVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIV 804 + +G S VY R+ +G+ + +KM P EV L+ RLRH NI+ Sbjct: 57 KIGAGFFSEVYKVRHRQSGQVMVLKMNKLPSN--------RSNTLREVQLMNRLRHPNIL 108 Query: 805 SFVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGI 984 F+ C +TEYM GG+L + L EP S P++L LALDIA+G+ YLH++G+ Sbjct: 109 RFMGVCVHQGQLHALTEYMNGGTLEQLLSSPEPLSWPVRL--HLALDIAQGLRYLHAKGV 166 Query: 985 LHRDLKSENVLLGED---MSVKVADFGIS-----CLESQCGSGKGFTGTYRWMAPEMIKE 1140 HRDL S+N L+ + + V DFG++ E G+ WMAPE+++ Sbjct: 167 FHRDLTSKNCLVRREDRGFTAVVGDFGLAEKIPVYREGTRKEPLAVVGSPYWMAPEVLRG 226 Query: 1141 KNHTRKVDVYSFGIVLWEILTALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLIS 1320 + + K DV++FGIVL E++ + + P + + R + CP+ L Sbjct: 227 ELYDEKADVFAFGIVLCELIARVPADPDYLPRTEDFGLDVPAFRTLVGNDCPLPFLLLAI 286 Query: 1321 QCWATNPDKRPQFDDIVVVLE 1383 C + P R F +I LE Sbjct: 287 HCCSMEPSTRAPFTEITQHLE 307
>Q01973:ROR1_HUMAN Tyrosine-protein kinase transmembrane receptor ROR1 precursor - Homo| sapiens (Human) Length = 937 Score = 122 bits (305), Expect = 6e-27 Identities = 77/234 (32%), Positives = 115/234 (49%), Gaps = 20/234 (8%) Frame = +1 Query: 751 QFASEVALLLRLRHHNIVSFVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHS------- 909 +F E +L+ L H NIV + A + C++ EY+ G L ++L + PHS Sbjct: 519 EFQQEASLMAELHHPNIVCLLGAVTQEQPVCMLFEYINQGDLHEFLIMRSPHSDVGCSSD 578 Query: 910 ----VPIQL----VLQLALDIARGMSYLHSQGILHRDLKSENVLLGEDMSVKVADFGIS- 1062 V L L +A+ IA GM YL S +H+DL + N+L+GE + VK++D G+S Sbjct: 579 EDGTVKSSLDHGDFLHIAIQIAAGMEYLSSHFFVHKDLAARNILIGEQLHVKISDLGLSR 638 Query: 1063 ---CLESQCGSGKGFTGTYRWMAPEMIKEKNHTRKVDVYSFGIVLWEILT-ALVPFSEMT 1230 + K RWM PE I + D++SFG+VLWEI + L P+ + Sbjct: 639 EIYSADYYRVQSKSLL-PIRWMPPEAIMYGKFSSDSDIWSFGVVLWEIFSFGLQPYYGFS 697 Query: 1231 PEQAAIAVALKNARPPLPASCPVAMSHLISQCWATNPDKRPQFDDIVVVLEGYK 1392 Q I + K P CP M L+++CW P +RP+F DI V L ++ Sbjct: 698 -NQEVIEMVRKRQLLPCSEDCPPRMYSLMTECWNEIPSRRPRFKDIHVRLRSWE 750
>Q3SWY2:ILK_BOVIN Integrin-linked protein kinase - Bos taurus (Bovine)| Length = 452 Score = 122 bits (305), Expect = 6e-27 Identities = 77/246 (31%), Positives = 128/246 (52%), Gaps = 7/246 (2%) Frame = +1 Query: 667 GRYNGREVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSFVAACKKPPVF-- 840 GR+ G ++ +KM+ + R F E L H N++ + AC+ PP Sbjct: 210 GRWQGNDIVVKMLKVRD----WSTRKSRDFNEECPRLRIFSHPNVLPVLGACQSPPAPHP 265 Query: 841 CIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGIL--HRDLKSENV 1014 +IT +M GSL LH+ V ++ ALD+ARGM++LH+ L L S +V Sbjct: 266 TLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMARGMAFLHTLEPLIPRHALNSRSV 325 Query: 1015 LLGEDMSVKVADFGISCLESQCGSGKGFTGTYRWMAPEMIKEK---NHTRKVDVYSFGIV 1185 ++ EDM+ +++ + QC G W+APE +++K + R D++SF ++ Sbjct: 326 MIDEDMTARISMADVK-FSFQC---PGRMYAPAWVAPEALQKKPEDTNRRSADMWSFAVL 381 Query: 1186 LWEILTALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATNPDKRPQFDD 1365 LWE++T VPF++++ + + VAL+ RP +P + L+ C +P KRP+FD Sbjct: 382 LWELVTREVPFADLSNMEIGMKVALEGLRPTIPPGISPHVCKLMKICMNEDPAKRPKFDM 441 Query: 1366 IVVVLE 1383 IV +LE Sbjct: 442 IVPILE 447
>Q61851:FGFR3_MOUSE Fibroblast growth factor receptor 3 precursor - Mus musculus (Mouse)| Length = 801 Score = 122 bits (305), Expect = 6e-27 Identities = 82/266 (30%), Positives = 131/266 (49%), Gaps = 19/266 (7%) Frame = +1 Query: 688 VAIKMVSQPHEDDALAAELERQFASEVALLLRL-RHHNIVSFVAACKKPPVFCIITEYMA 864 VA+KM+ +DDA +L SE+ ++ + +H NI++ + AC + ++ EY A Sbjct: 499 VAVKML----KDDATDKDLS-DLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAA 553 Query: 865 GGSLRKYLHQQEPHSVPIQL--------------VLQLALDIARGMSYLHSQGILHRDLK 1002 G+LR++L + P + ++ A +ARGM YL SQ +HRDL Sbjct: 554 KGNLREFLRARRPPGMDYSFDACRLPEEQLTCKDLVSCAYQVARGMEYLASQKCIHRDLA 613 Query: 1003 SENVLLGEDMSVKVADFGISCLESQCGSGKGFTG---TYRWMAPEMIKEKNHTRKVDVYS 1173 + NVL+ ED +K+ADFG++ K T +WMAPE + ++ +T + DV+S Sbjct: 614 ARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWS 673 Query: 1174 FGIVLWEILTALVPFS-EMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATNPDKR 1350 FG++LWEI T P P + + + R PASC + ++ +CW P +R Sbjct: 674 FGVLLWEIFTPGGPSPYPGIPVEELFKLLKEGHRMDKPASCTHDLYMIMRECWHAVPSQR 733 Query: 1351 PQFDDIVVVLEGYKEALDNDPSFFLS 1428 P F +V L+ D LS Sbjct: 734 PTFKQLVEDLDRILTVTSTDEYLDLS 759
>Q13546:RIPK1_HUMAN Receptor-interacting serine/threonine-protein kinase 1 - Homo sapiens| (Human) Length = 671 Score = 121 bits (304), Expect = 8e-27 Identities = 72/221 (32%), Positives = 107/221 (48%), Gaps = 19/221 (8%) Frame = +1 Query: 763 EVALLLRLRHHNIVSFVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLAL 942 E ++ RLRH +V + + + ++ EYM G+L L + S P+ + ++ L Sbjct: 63 EAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEM--STPLSVKGRIIL 120 Query: 943 DIARGMSYLHSQGILHRDLKSENVLLGEDMSVKVADFGISC--------------LESQC 1080 +I GM YLH +G++H+DLK EN+L+ D +K+AD G++ L Sbjct: 121 EIIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVD 180 Query: 1081 GSGKGFTGTYRWMAPEMIKEKN--HTRKVDVYSFGIVLWEILTALVPFSEMTPEQAAIAV 1254 G+ K GT +MAPE + + N T K DVYSF +VLW I P+ EQ I Sbjct: 181 GTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMC 240 Query: 1255 ALKNARP---PLPASCPVAMSHLISQCWATNPDKRPQFDDI 1368 RP + CP + L+ CW NP+ RP F I Sbjct: 241 IKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGI 281
>Q32L23:LIMK2_BOVIN LIM domain kinase 2 - Bos taurus (Bovine)| Length = 638 Score = 121 bits (304), Expect = 8e-27 Identities = 82/243 (33%), Positives = 118/243 (48%), Gaps = 22/243 (9%) Frame = +1 Query: 739 ELERQFASEVALLLRLRHHNIVSFVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPI 918 E ++ F +EV ++ L H N++ F+ K ++TEY+ GG+L+ +L +P P Sbjct: 368 ETQKTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRNVDPF--PW 425 Query: 919 QLVLQLALDIARGMSYLHSQGILHRDLKSENVLLGEDMSVKVADFGISCL---------- 1068 Q ++ A IA GM+YLHS I+HRDL S N L+ D +V VADFG+S L Sbjct: 426 QQKVRFAKGIASGMAYLHSMCIIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKKPPV 485 Query: 1069 -----------ESQCGSGKGFTGTYRWMAPEMIKEKNHTRKVDVYSFGIVLWEILTALVP 1215 +S G WMAPEM+ K++ VDV+SFGIVL EI+ + Sbjct: 486 EKATTKKRTLRKSDRKKRYTVVGNPYWMAPEMLNGKSYDETVDVFSFGIVLCEIIGQVYA 545 Query: 1216 FSEMTPEQAAIAVALKNA-RPPLPASCPVAMSHLISQCWATNPDKRPQFDDIVVVLEGYK 1392 + P + +K +P CP A L + C P+ RP F LE + Sbjct: 546 DPDCLPRTLDFGLNVKLFWEKFVPEECPPAFFPLAAICCRLEPESRPAFSK----LEDFF 601 Query: 1393 EAL 1401 EAL Sbjct: 602 EAL 604
>O42565:LIMK1_XENLA LIM domain kinase 1 - Xenopus laevis (African clawed frog)| Length = 615 Score = 121 bits (304), Expect = 8e-27 Identities = 79/227 (34%), Positives = 117/227 (51%), Gaps = 12/227 (5%) Frame = +1 Query: 739 ELERQFASEVALLLRLRHHNIVSFVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPI 918 E +R F EV ++ L H +++ F+ K ITEY+ GG+LR+ + + H P Sbjct: 351 ETQRTFLKEVKVMRCLEHPHVLKFIGVLYKDKRLNFITEYIPGGTLRRVIKSMDTHC-PW 409 Query: 919 QLVLQLALDIARGMSYLHSQGILHRDLKSENVLLGEDMSVKVADFGISCL------ESQC 1080 + A DIA GM+YLHS I+HRDL S N L+ ED + VA+FG+S L + + Sbjct: 410 NQRVSFARDIAAGMTYLHSMNIIHRDLNSHNCLVREDGGLVVANFGLSRLIPEETRDLRK 469 Query: 1081 GSGKGFT--GTYRWMAPEMIKEKNHTRKVDVYSFGIVLWEILTALVPFSEMTPEQAAIAV 1254 K +T G WMAPEMI +++ VDV+SFGIV+ EI+ + + P + Sbjct: 470 DRRKRYTVVGNPYWMAPEMINGRSYDESVDVFSFGIVICEIIGLVNADPDYLPRTMDFGL 529 Query: 1255 ALKNARPPL----PASCPVAMSHLISQCWATNPDKRPQFDDIVVVLE 1383 N R L P +CP C +P+KRP+F + + L+ Sbjct: 530 ---NVRAFLDRFCPPNCPPGFFPSAVLCCDLDPEKRPRFSQLQLWLD 573
>P53669:LIMK1_RAT LIM domain kinase 1 - Rattus norvegicus (Rat)| Length = 647 Score = 121 bits (304), Expect = 8e-27 Identities = 81/237 (34%), Positives = 118/237 (49%), Gaps = 16/237 (6%) Frame = +1 Query: 739 ELERQFASEVALLLRLRHHNIVSFVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPI 918 E +R F EV ++ L H N++ F+ K ITEY+ GG+LR + + P Sbjct: 376 ETQRTFLKEVKVMRCLEHPNVLKFIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQ-YPW 434 Query: 919 QLVLQLALDIARGMSYLHSQGILHRDLKSENVLLGEDMSVKVADFGISCLE-SQCGSGKG 1095 + A DIA GM+YLHS I+HRDL S N L+ E+ +V VADFG++ L + G + Sbjct: 435 SQRVSFAKDIASGMAYLHSMNIIHRDLNSHNCLVRENRNVVVADFGLARLMIDEKGQSED 494 Query: 1096 F--------------TGTYRWMAPEMIKEKNHTRKVDVYSFGIVLWEILTALVPFSEMTP 1233 G WMAPEMI +++ KVDV+SFGIVL EI+ + + P Sbjct: 495 LRSLKKPDRKKRYTVVGNPYWMAPEMINGRSYDEKVDVFSFGIVLCEIIGRVNADPDYLP 554 Query: 1234 EQAAIAVALKNARPP-LPASCPVAMSHLISQCWATNPDKRPQFDDIVVVLEGYKEAL 1401 + ++ P +CP + + +C +P+KRP F V LE + E L Sbjct: 555 RTMDFGLNVRGFLDRYCPPNCPPSFFPITVRCCDLDPEKRPSF----VKLEQWLETL 607
>P53668:LIMK1_MOUSE LIM domain kinase 1 - Mus musculus (Mouse)| Length = 647 Score = 121 bits (304), Expect = 8e-27 Identities = 82/237 (34%), Positives = 119/237 (50%), Gaps = 16/237 (6%) Frame = +1 Query: 739 ELERQFASEVALLLRLRHHNIVSFVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPI 918 E +R F EV ++ L H N++ F+ K ITEY+ GG+LR + + P Sbjct: 376 ETQRTFLKEVKVMRCLEHPNVLKFIGVLYKDKRLNFITEYIKGGTLRGIIKNMDSQ-YPW 434 Query: 919 QLVLQLALDIARGMSYLHSQGILHRDLKSENVLLGEDMSVKVADFGISCLE--------- 1071 + A DIA GM+YLHS I+HRDL S N L+ E+ +V VADFG++ L Sbjct: 435 SQRVSFAKDIASGMAYLHSMNIIHRDLNSHNCLVRENRNVVVADFGLARLMIDEKNQSED 494 Query: 1072 ----SQCGSGKGFT--GTYRWMAPEMIKEKNHTRKVDVYSFGIVLWEILTALVPFSEMTP 1233 + K +T G WMAPEMI +++ KVDV+SFGIVL EI+ + + P Sbjct: 495 LRSLKKPDRKKRYTVVGNPYWMAPEMINGRSYDEKVDVFSFGIVLCEIIGRVNADPDYLP 554 Query: 1234 EQAAIAVALKNARPP-LPASCPVAMSHLISQCWATNPDKRPQFDDIVVVLEGYKEAL 1401 + ++ P +CP + + +C +P+KRP F V LE + E L Sbjct: 555 RTMDFGLNVRGFLDRYCPPNCPPSFFPITVRCCDLDPEKRPSF----VKLEQWLETL 607
>P08069:IGF1R_HUMAN Insulin-like growth factor 1 receptor precursor - Homo sapiens| (Human) Length = 1367 Score = 121 bits (304), Expect = 8e-27 Identities = 81/261 (31%), Positives = 132/261 (50%), Gaps = 14/261 (5%) Frame = +1 Query: 688 VAIKMVSQPHEDDALAAELER-QFASEVALLLRLRHHNIVSFVAACKKPPVFCIITEYMA 864 VAIK V++ A+ ER +F +E +++ H++V + + +I E M Sbjct: 1030 VAIKTVNEA------ASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMT 1083 Query: 865 GGSLRKYLHQQEPHSV--------PIQLVLQLALDIARGMSYLHSQGILHRDLKSENVLL 1020 G L+ YL P + ++Q+A +IA GM+YL++ +HRDL + N ++ Sbjct: 1084 RGDLKSYLRSLRPEMENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMV 1143 Query: 1021 GEDMSVKVADFGISC----LESQCGSGKGFTGTYRWMAPEMIKEKNHTRKVDVYSFGIVL 1188 ED +VK+ DFG++ + GKG RWM+PE +K+ T DV+SFG+VL Sbjct: 1144 AEDFTVKIGDFGMTRDIYETDYYRKGGKGLL-PVRWMSPESLKDGVFTTYSDVWSFGVVL 1202 Query: 1189 WEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATNPDKRPQFDD 1365 WEI T A P+ ++ EQ + ++ P +CP + L+ CW NP RP F + Sbjct: 1203 WEIATLAEQPYQGLSNEQ-VLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLE 1261 Query: 1366 IVVVLEGYKEALDNDPSFFLS 1428 I+ ++ E + SF+ S Sbjct: 1262 IISSIKEEMEPGFREVSFYYS 1282
>P22607:FGFR3_HUMAN Fibroblast growth factor receptor 3 precursor - Homo sapiens (Human)| Length = 806 Score = 121 bits (304), Expect = 8e-27 Identities = 80/265 (30%), Positives = 130/265 (49%), Gaps = 18/265 (6%) Frame = +1 Query: 688 VAIKMVSQPHEDDALAAELERQFASEVALLLRL-RHHNIVSFVAACKKPPVFCIITEYMA 864 VA+KM+ +DDA +L SE+ ++ + +H NI++ + AC + ++ EY A Sbjct: 505 VAVKML----KDDATDKDLS-DLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAA 559 Query: 865 GGSLRKYLHQQEPHSVPIQL--------------VLQLALDIARGMSYLHSQGILHRDLK 1002 G+LR++L + P + ++ A +ARGM YL SQ +HRDL Sbjct: 560 KGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLA 619 Query: 1003 SENVLLGEDMSVKVADFGISCLESQCGSGKGFTG---TYRWMAPEMIKEKNHTRKVDVYS 1173 + NVL+ ED +K+ADFG++ K T +WMAPE + ++ +T + DV+S Sbjct: 620 ARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWS 679 Query: 1174 FGIVLWEILTALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATNPDKRP 1353 FG++LWEI T P + + + R PA+C + ++ +CW P +RP Sbjct: 680 FGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRP 739 Query: 1354 QFDDIVVVLEGYKEALDNDPSFFLS 1428 F +V L+ D LS Sbjct: 740 TFKQLVEDLDRVLTVTSTDEYLDLS 764
>P18460:FGFR3_CHICK Fibroblast growth factor receptor 3 precursor - Gallus gallus| (Chicken) Length = 806 Score = 121 bits (304), Expect = 8e-27 Identities = 77/250 (30%), Positives = 127/250 (50%), Gaps = 18/250 (7%) Frame = +1 Query: 688 VAIKMVSQPHEDDALAAELERQFASEVALLLRL-RHHNIVSFVAACKKPPVFCIITEYMA 864 VA+KM+ +DDA +L SE+ ++ + +H NI++ + AC + ++ EY + Sbjct: 499 VAVKML----KDDATDKDLS-DLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVLVEYAS 553 Query: 865 GGSLRKYLHQQEPHSVPIQL--------------VLQLALDIARGMSYLHSQGILHRDLK 1002 G+LR+YL + P + ++ A +ARGM YL SQ +HRDL Sbjct: 554 KGNLREYLRARRPPGMDYSFDTCKLPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLA 613 Query: 1003 SENVLLGEDMSVKVADFGISCLESQCGSGKGFTG---TYRWMAPEMIKEKNHTRKVDVYS 1173 + NVL+ ED +K+ADFG++ K T +WMAPE + ++ +T + DV+S Sbjct: 614 ARNVLVTEDNVMKIADFGLARDVHNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWS 673 Query: 1174 FGIVLWEILTALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATNPDKRP 1353 FG++LWEI T P + + + R PA+C + ++ +CW P +RP Sbjct: 674 FGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAVPSQRP 733 Query: 1354 QFDDIVVVLE 1383 F +V L+ Sbjct: 734 TFKQLVEDLD 743
>P00542:FES_FSVGA Tyrosine-protein kinase transforming protein Fes - Feline sarcoma| virus (strain Gardner-Arnstein) (Ga-FeSV) (Gardner-Arnstein feline leukemia oncovirus B) Length = 609 Score = 121 bits (304), Expect = 8e-27 Identities = 77/255 (30%), Positives = 125/255 (49%), Gaps = 4/255 (1%) Frame = +1 Query: 643 GRHSRVYFGRYNGREVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSFVAAC 822 G V+ GR + + S + L +++ +F E +L + H NIV + C Sbjct: 357 GNFGEVFSGRLRADNTLVAVKSCR---ETLPPDIKAKFLQEAKILKQYSHPNIVRLIGVC 413 Query: 823 KKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGILHRDLK 1002 + I+ E + GG +L + E + ++ +LQ+ D A GM YL S+ +HRDL Sbjct: 414 TQKQPIYIVMELVQGGDFLTFL-RTEGARLRMKTLLQMVGDAAAGMEYLESKCCIHRDLA 472 Query: 1003 SENVLLGEDMSVKVADFGISCLESQ---CGSGKGFTGTYRWMAPEMIKEKNHTRKVDVYS 1173 + N L+ E +K++DFG+S + SG +W APE + ++ + DV+S Sbjct: 473 ARNCLVTEKNVLKISDFGMSREAADGIYAASGGLRQVPVKWTAPEALNYGRYSSESDVWS 532 Query: 1174 FGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATNPDKR 1350 FGI+LWE + P+ ++ +Q V K R P P CP A+ L+ QCWA P +R Sbjct: 533 FGILLWETFSLGASPYPNLSNQQTREFVE-KGGRLPCPELCPDAVFRLMEQCWAYEPGQR 591 Query: 1351 PQFDDIVVVLEGYKE 1395 P F I L+ ++ Sbjct: 592 PSFSAIYQELQSIRK 606
>P42680:TEC_HUMAN Tyrosine-protein kinase Tec - Homo sapiens (Human)| Length = 631 Score = 121 bits (303), Expect = 1e-26 Identities = 72/252 (28%), Positives = 123/252 (48%), Gaps = 4/252 (1%) Frame = +1 Query: 640 SGRHSRVYFGRYNGR-EVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSFVA 816 SG V G++ + +VAIK + + A E F E ++++L H +V Sbjct: 378 SGLFGVVRLGKWRAQYKVAIKAIRE-------GAMCEEDFIEEAKVMMKLTHPKLVQLYG 430 Query: 817 ACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGILHRD 996 C + I+TE+M G L +L Q++ H ++L + D+ GM YL +HRD Sbjct: 431 VCTQQKPIYIVTEFMERGCLLNFLRQRQGH-FSRDVLLSMCQDVCEGMEYLERNSFIHRD 489 Query: 997 LKSENVLLGEDMSVKVADFGIS--CLESQCGSGKGFTGTYRWMAPEMIKEKNHTRKVDVY 1170 L + N L+ E VKV+DFG++ L+ Q S G +W PE+ + K DV+ Sbjct: 490 LAARNCLVSEAGVVKVSDFGMARYFLDDQYTSSSGAKFPVKWCPPEVFNYSRFSSKSDVW 549 Query: 1171 SFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATNPDK 1347 SFG+++WE+ T +PF + T + + + R P + ++ +CW P+ Sbjct: 550 SFGVLMWEVFTEGRMPFEKYT-NYEVVTMVTRGHRLYQPKLASNYVYEVMLRCWQEKPEG 608 Query: 1348 RPQFDDIVVVLE 1383 RP F+D++ ++ Sbjct: 609 RPSFEDLLRTID 620
>Q9V6K3:ROR2_DROME Tyrosine-protein kinase transmembrane receptor Ror2 precursor -| Drosophila melanogaster (Fruit fly) Length = 724 Score = 121 bits (303), Expect = 1e-26 Identities = 81/242 (33%), Positives = 124/242 (51%), Gaps = 15/242 (6%) Frame = +1 Query: 688 VAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSFVAACKKPPVFCIITEYMAG 867 VA+KM+ +DDA + +++ F E LL H NIV + C C++ EYMA Sbjct: 472 VAVKML----KDDA-SDQMQMDFEREACLLAEFDHPNIVRLLGVCALGRPMCLLFEYMAP 526 Query: 868 GSLRKYLHQQEP---HSVPIQ--------LVLQLALDIARGMSYLHSQGILHRDLKSENV 1014 G L ++L P H P Q +LQ+A +IA GM YL + +HRDL + N Sbjct: 527 GDLSEFLRACSPYATHQAPTQDRLQLNELHLLQMAANIAAGMLYLSERKFVHRDLATRNC 586 Query: 1015 LLGEDMSVKVADFGIS---CLESQCGSGKGFTGTYRWMAPEMIKEKNHTRKVDVYSFGIV 1185 L+ E M+VK+ADFG+S L+ + RWM E I + + DV+++GI Sbjct: 587 LINEHMAVKIADFGLSHKIYLQDYYKGDENDFIPIRWMPLESILYNKFSLESDVWAYGIC 646 Query: 1186 LWEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATNPDKRPQFD 1362 LWE+ + AL P+ +T E+ + N P + P+++ L+ +CW P +RP F Sbjct: 647 LWEVFSFALQPYFGLTHEEVIKYIKEGNVL-GCPDNTPLSVYALMRRCWNRKPSERPGFA 705 Query: 1363 DI 1368 +I Sbjct: 706 EI 707
>Q08881:ITK_HUMAN Tyrosine-protein kinase ITK/TSK - Homo sapiens (Human)| Length = 620 Score = 121 bits (303), Expect = 1e-26 Identities = 70/250 (28%), Positives = 127/250 (50%), Gaps = 6/250 (2%) Frame = +1 Query: 640 SGRHSRVYFGRY-NGREVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSFVA 816 SG+ V+ G + N +VAIK + + A E F E ++++L H +V Sbjct: 371 SGQFGLVHLGYWLNKDKVAIKTIRE-------GAMSEEDFIEEAEVMMKLSHPKLVQLYG 423 Query: 817 ACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGILHRD 996 C + C++ E+M G L YL Q + +L + LD+ GM+YL ++HRD Sbjct: 424 VCLEQAPICLVFEFMEHGCLSDYLRTQRG-LFAAETLLGMCLDVCEGMAYLEEACVIHRD 482 Query: 997 LKSENVLLGEDMSVKVADFGIS--CLESQCGSGKGFTGTYRWMAPEMIKEKNHTRKVDVY 1170 L + N L+GE+ +KV+DFG++ L+ Q S G +W +PE+ ++ K DV+ Sbjct: 483 LAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVW 542 Query: 1171 SFGIVLWEILT-ALVPFSEMTPEQAA--IAVALKNARPPLPASCPVAMSHLISQCWATNP 1341 SFG+++WE+ + +P+ + + I+ + +P L ++ + +++ CW P Sbjct: 543 SFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLAST---HVYQIMNHCWKERP 599 Query: 1342 DKRPQFDDIV 1371 + RP F ++ Sbjct: 600 EDRPAFSRLL 609
>Q91287:FGFR3_PLEWA Fibroblast growth factor receptor 3 precursor - Pleurodeles waltlii| (Iberian ribbed newt) Length = 796 Score = 121 bits (303), Expect = 1e-26 Identities = 79/265 (29%), Positives = 130/265 (49%), Gaps = 18/265 (6%) Frame = +1 Query: 688 VAIKMVSQPHEDDALAAELERQFASEVALLLRL-RHHNIVSFVAACKKPPVFCIITEYMA 864 VA+KM+ +DDA +L SE+ ++ + +H NI++ + AC + ++ EY + Sbjct: 490 VAVKML----KDDATDKDLS-DLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVLVEYAS 544 Query: 865 GGSLRKYLHQQEPHSVPIQL--------------VLQLALDIARGMSYLHSQGILHRDLK 1002 G+LR+YL + P + ++ A +ARGM YL SQ +HRDL Sbjct: 545 KGNLREYLRARRPPGMDYSFDTCKLPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLA 604 Query: 1003 SENVLLGEDMSVKVADFGISCLESQCGSGKGFTG---TYRWMAPEMIKEKNHTRKVDVYS 1173 + NVL+ +D +K+ADFG++ K T +WMAPE + ++ +T + DV+S Sbjct: 605 ARNVLVTDDNVMKIADFGLARDVHNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWS 664 Query: 1174 FGIVLWEILTALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATNPDKRP 1353 FG++LWEI T P + + + R PA+C + ++ +CW P +RP Sbjct: 665 FGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHELYMIMRECWHAVPSQRP 724 Query: 1354 QFDDIVVVLEGYKEALDNDPSFFLS 1428 F +V L+ D LS Sbjct: 725 TFKQLVEDLDRVLTVTSTDEYLDLS 749
>P22182:FGFR1_XENLA Fibroblast growth factor receptor 1 precursor - Xenopus laevis| (African clawed frog) Length = 812 Score = 121 bits (303), Expect = 1e-26 Identities = 77/250 (30%), Positives = 127/250 (50%), Gaps = 17/250 (6%) Frame = +1 Query: 685 EVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSFVAACKKPPVFCIITEYMA 864 +VA+KM+ + DA +L + + + +H NI++ + AC + +I EY + Sbjct: 504 KVAVKML----KSDASEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYTS 559 Query: 865 GGSLRKYLHQQEPHS---------VPIQLV-----LQLALDIARGMSYLHSQGILHRDLK 1002 G+LR+YL + P + VP QL+ + A +ARGM YL S+ +HRDL Sbjct: 560 KGNLREYLRARRPPAMEYCYNPTCVPDQLLSFKDLVSCAYQVARGMDYLASKKCIHRDLA 619 Query: 1003 SENVLLGEDMSVKVADFGISCLESQCGSGKGFTG---TYRWMAPEMIKEKNHTRKVDVYS 1173 + NVL+ ED +K+ADFG++ K T +WMAPE + ++ +T + DV+S Sbjct: 620 ARNVLVTEDNIMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWS 679 Query: 1174 FGIVLWEILTALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATNPDKRP 1353 FG++LWEI T P + + + R P +C + ++ CW P +RP Sbjct: 680 FGVLLWEIFTLGGSPYPGVPMEELFKLLKEGHRMDKPTNCTNELYMMMKDCWHAMPSQRP 739 Query: 1354 QFDDIVVVLE 1383 F+ +V L+ Sbjct: 740 TFNQLVEDLD 749
>O09127:EPHA8_MOUSE Ephrin type-A receptor 8 precursor - Mus musculus (Mouse)| Length = 1004 Score = 121 bits (303), Expect = 1e-26 Identities = 89/259 (34%), Positives = 128/259 (49%), Gaps = 11/259 (4%) Frame = +1 Query: 640 SGRHSRVYFGRYN--GRE---VAIKMVSQPHEDDALAAELERQ-FASEVALLLRLRHHNI 801 SG V +GR G+ VAIK + + E +RQ F SE A++ + H NI Sbjct: 642 SGESGEVCYGRLQVPGQRDVPVAIKALKAGY------TERQRQDFLSEAAIMGQFDHPNI 695 Query: 802 VSFVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQG 981 + + + I+TEYM GSL +L + +QLV L + GM YL G Sbjct: 696 IRLEGVVTRGRLAMIVTEYMENGSLDAFLRTHDGQFTIVQLVGMLR-GVGAGMRYLSDLG 754 Query: 982 ILHRDLKSENVLLGEDMSVKVADFGIS-CLESQCGSGKGFTG---TYRWMAPEMIKEKNH 1149 +HRDL + NVL+ + KV+DFG+S LE + G RW APE I + Sbjct: 755 YIHRDLAARNVLVDGRLVCKVSDFGLSRALEDDPEAAYTTAGGKIPIRWTAPEAIAFRTF 814 Query: 1150 TRKVDVYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQC 1326 + DV+SFG+V+WE+L P+ MT Q I+ + R P P CP A+ L+ C Sbjct: 815 SSASDVWSFGVVMWEVLAYGERPYWNMT-NQDVISSVEEGYRLPAPMGCPRALHQLMLDC 873 Query: 1327 WATNPDKRPQFDDIVVVLE 1383 W + +RP+F +V VL+ Sbjct: 874 WHKDRAQRPRFAHVVSVLD 892
>Q91571:EPB1A_XENLA Ephrin type-B receptor 1-A precursor - Xenopus laevis (African clawed| frog) Length = 985 Score = 121 bits (303), Expect = 1e-26 Identities = 84/259 (32%), Positives = 128/259 (49%), Gaps = 12/259 (4%) Frame = +1 Query: 640 SGRHSRVYFGRY---NGRE--VAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIV 804 +G VY GR + RE VAIK + + + + R F SE +++ + H NI+ Sbjct: 628 AGEFGEVYKGRLKLPSKREISVAIKTLKAGYSE-----KQRRDFLSEASIMGQFDHPNII 682 Query: 805 SFVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGI 984 K IITE+M G+L +L Q + IQLV L IA GM YL Sbjct: 683 RLEGVVTKSRPVMIITEFMENGALDSFLRQNDGQFTVIQLVGMLR-GIAAGMKYLSEMNY 741 Query: 985 LHRDLKSENVLLGEDMSVKVADFGISCLESQCGSGKGFTGT------YRWMAPEMIKEKN 1146 +HRDL + N+L+ ++ KV+DFG+S S +T + RW A E I + Sbjct: 742 VHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTAQEAIAYRK 801 Query: 1147 HTRKVDVYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQ 1323 T DV+S+GIV+WE+++ P+ M+ + A+ ++ R P P CP A+ L+ Sbjct: 802 FTSASDVWSYGIVMWEVMSYGERPYWTMSNQDVINAIE-QDYRLPPPMDCPAALHQLMLD 860 Query: 1324 CWATNPDKRPQFDDIVVVL 1380 CW + + RP+ +IV L Sbjct: 861 CWQKDRNSRPRLAEIVNTL 879
>P24604:TEC_MOUSE Tyrosine-protein kinase Tec - Mus musculus (Mouse)| Length = 630 Score = 120 bits (302), Expect = 1e-26 Identities = 72/252 (28%), Positives = 122/252 (48%), Gaps = 4/252 (1%) Frame = +1 Query: 640 SGRHSRVYFGRYNGR-EVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSFVA 816 SG V G++ + +VAIK + + A E F E ++++L H +V Sbjct: 377 SGLFGVVRLGKWRAQYKVAIKAIRE-------GAMCEEDFIEEAKVMMKLTHPKLVQLYG 429 Query: 817 ACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGILHRD 996 C + I+TE+M G L +L Q++ H ++L + D+ GM YL +HRD Sbjct: 430 VCTQQKPIYIVTEFMERGCLLNFLRQRQGH-FSRDMLLSMCQDVCEGMEYLERNSFIHRD 488 Query: 997 LKSENVLLGEDMSVKVADFGIS--CLESQCGSGKGFTGTYRWMAPEMIKEKNHTRKVDVY 1170 L + N L+ E VKV+DFG++ L+ Q S G +W PE+ + K DV+ Sbjct: 489 LAARNCLVNEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFNYSRFSSKSDVW 548 Query: 1171 SFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATNPDK 1347 SFG+++WEI T +PF + T + + + R P + ++ +CW P+ Sbjct: 549 SFGVLMWEIFTEGRMPFEKNT-NYEVVTMVTRGHRLHRPKLATKYLYEVMLRCWQERPEG 607 Query: 1348 RPQFDDIVVVLE 1383 RP +D++ ++ Sbjct: 608 RPSLEDLLRTID 619
>P42688:SRK2_SPOLA Tyrosine-protein kinase SRK2 - Spongilla lacustris (Freshwater| sponge) Length = 362 Score = 120 bits (302), Expect = 1e-26 Identities = 78/257 (30%), Positives = 130/257 (50%), Gaps = 4/257 (1%) Frame = +1 Query: 631 RFASGRHSRVYFGRYNGRE-VAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVS 807 + +G+ VY G +N VA+K + A F +E ++ +LRH ++ Sbjct: 100 KLGAGQFGEVYQGLWNNSTPVAVKTLKAGTMQPAA-------FLAEAQIMKKLRHPKLIQ 152 Query: 808 FVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGIL 987 A C + IITE M+ GSL YL Q E ++ + ++ +A +A GM+YL + Sbjct: 153 LYAVCTQGEPVYIITELMSKGSLLDYL-QGEAGALKLPQLIDMAAQVAAGMAYLELHNYI 211 Query: 988 HRDLKSENVLLGEDMSVKVADFGISCL--ESQCGSGKGFTGTYRWMAPEMIKEKNHTRKV 1161 HRDL + N+L+G++ KVADFG++ L + +G +W APE + K Sbjct: 212 HRDLAARNILVGDNNICKVADFGLARLIVSDDYNATEGAKFPIKWTAPEAALFNRFSIKS 271 Query: 1162 DVYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATN 1338 DV+SFGI++ E++T +P+ M+ + + K R P P + P ++ ++ CW N Sbjct: 272 DVWSFGILITELVTYGRIPYPGMSNAE-VLQNLDKGYRMPCPVTTPESLYQIMLDCWKRN 330 Query: 1339 PDKRPQFDDIVVVLEGY 1389 P RP F+ + LE + Sbjct: 331 PADRPTFEALQWRLEDF 347
>P53671:LIMK2_HUMAN LIM domain kinase 2 - Homo sapiens (Human)| Length = 638 Score = 120 bits (302), Expect = 1e-26 Identities = 77/232 (33%), Positives = 114/232 (49%), Gaps = 22/232 (9%) Frame = +1 Query: 739 ELERQFASEVALLLRLRHHNIVSFVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPI 918 E ++ F +EV ++ L H N++ F+ K ++TEY+ GG+L+ +L +P P Sbjct: 368 ETQKTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRSMDPF--PW 425 Query: 919 QLVLQLALDIARGMSYLHSQGILHRDLKSENVLLGEDMSVKVADFGISCL----ESQCGS 1086 Q ++ A IA GM+YLHS I+HRDL S N L+ D +V VADFG+S L + Sbjct: 426 QQKVRFAKGIASGMAYLHSMCIIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPM 485 Query: 1087 GKGFT-----------------GTYRWMAPEMIKEKNHTRKVDVYSFGIVLWEILTALVP 1215 K T G WMAPEM+ K++ VD++SFGIVL EI+ + Sbjct: 486 EKATTKKRTLRKNDRKKRYTVVGNPYWMAPEMLNGKSYDETVDIFSFGIVLCEIIGQVYA 545 Query: 1216 FSEMTPEQAAIAVALKNA-RPPLPASCPVAMSHLISQCWATNPDKRPQFDDI 1368 + P + +K +P CP A L + C P+ RP F + Sbjct: 546 DPDCLPRTLDFGLNVKLFWEKFVPTDCPPAFFPLAAICCRLEPESRPAFSKL 597
>P15208:INSR_MOUSE Insulin receptor precursor - Mus musculus (Mouse)| Length = 1372 Score = 120 bits (302), Expect = 1e-26 Identities = 81/260 (31%), Positives = 133/260 (51%), Gaps = 13/260 (5%) Frame = +1 Query: 688 VAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSFVAACKKPPVFCIITEYMAG 867 VA+K V+ E +L +E F +E +++ H++V + K ++ E MA Sbjct: 1044 VAVKTVN---ESASLRERIE--FLNEASVMKGFTCHHVVRLLGVVSKGQPMLVVMELMAH 1098 Query: 868 GSLRKYLHQQEPHSV--------PIQLVLQLALDIARGMSYLHSQGILHRDLKSENVLLG 1023 G L+ +L P + +Q ++Q+ +IA GM+YL+++ +HRDL + N ++ Sbjct: 1099 GDLKSHLRSLRPDAENNPGRPPPTLQEMIQMTAEIADGMAYLNAKKFVHRDLAARNCMVA 1158 Query: 1024 EDMSVKVADFGISC----LESQCGSGKGFTGTYRWMAPEMIKEKNHTRKVDVYSFGIVLW 1191 D +VK+ DFG++ + GKG RWM+PE +K+ T D++SFG+VLW Sbjct: 1159 HDFTVKIGDFGMTRDIYETDYYRKGGKGLL-PVRWMSPESLKDGVFTASSDMWSFGVVLW 1217 Query: 1192 EILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATNPDKRPQFDDI 1368 EI + A P+ ++ EQ V P P +CP ++ L+ CW NP RP F +I Sbjct: 1218 EITSLAEQPYQGLSNEQVLKFVMDGGYLDP-PDNCPERLTDLMRMCWQFNPKMRPTFLEI 1276 Query: 1369 VVVLEGYKEALDNDPSFFLS 1428 V +L+ + SFF S Sbjct: 1277 VNLLKDDLHPSFPEVSFFYS 1296
>P53356:HTK16_HYDAT Tyrosine-protein kinase HTK16 - Hydra attenuata (Hydra) (Hydra| vulgaris) Length = 757 Score = 120 bits (302), Expect = 1e-26 Identities = 78/238 (32%), Positives = 123/238 (51%), Gaps = 8/238 (3%) Frame = +1 Query: 679 GREVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSFVAACKKPPVFCIITEY 858 G+E+ + M + H+D + E ++F E ++ +L H IVS + C PP+ ++ E Sbjct: 508 GKEINVAMKTL-HKDKMVQGE--KEFLREALVMSQLNHPCIVSLLGVCLGPPMI-LVQEL 563 Query: 859 MAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGILHRDLKSENVLLGEDMSV 1038 + G+L YL +P + L L A IA GM YL + +HRDL + N+LL V Sbjct: 564 VEMGALLDYLMDYQPEIQEVDLKLW-ASQIAFGMMYLELKRFVHRDLAARNILLANKKQV 622 Query: 1039 KVADFGISCLESQCGSG-------KGFTGTYRWMAPEMIKEKNHTRKVDVYSFGIVLWEI 1197 K++DFG+S G+G +G RW APE I + K DV+S+GI LWE+ Sbjct: 623 KISDFGLS---RAVGTGSDYYQAKQGGRWPVRWYAPESINYGTFSTKSDVWSYGITLWEM 679 Query: 1198 LT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATNPDKRPQFDDI 1368 T +P+ EMT + ++ R P CP+ ++ CW +P+KRP F+++ Sbjct: 680 FTFGDLPYGEMTGNE-VVSFLEHCGRLEKPDECPIHTYSIMLSCWHIDPNKRPTFNEL 736
>O42422:EPHA7_CHICK Ephrin type-A receptor 7 precursor - Gallus gallus (Chicken)| Length = 993 Score = 120 bits (302), Expect = 1e-26 Identities = 73/217 (33%), Positives = 113/217 (52%), Gaps = 5/217 (2%) Frame = +1 Query: 748 RQFASEVALLLRLRHHNIVSFVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLV 927 R F E +++ + H N+V + I+ EYM G+L +L + + IQLV Sbjct: 672 RDFLCEASIMGQFDHPNVVHLEGVVTRGKPVMIVIEYMENGALDAFLRKHDGQFTVIQLV 731 Query: 928 LQLALDIARGMSYLHSQGILHRDLKSENVLLGEDMSVKVADFGIS-CLESQCGSGKGFTG 1104 L IA GM YL G +HRDL + N+L+ ++ KV+DFG+S +E + TG Sbjct: 732 GMLR-GIAAGMRYLADMGYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTG 790 Query: 1105 ---TYRWMAPEMIKEKNHTRKVDVYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNAR 1272 RW APE I+ + T DV+S+GIV+WE+++ P+ +M+ Q I + R Sbjct: 791 GKIPVRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMS-NQDVIKAIEEGYR 849 Query: 1273 PPLPASCPVAMSHLISQCWATNPDKRPQFDDIVVVLE 1383 P P CP + L+ CW +RP+F+ IV +L+ Sbjct: 850 LPAPMDCPAGLHQLMLDCWQKERGERPKFEQIVGILD 886
>Q8JH64:BTK_CHICK Tyrosine-protein kinase BTK - Gallus gallus (Chicken)| Length = 657 Score = 120 bits (302), Expect = 1e-26 Identities = 73/248 (29%), Positives = 123/248 (49%), Gaps = 4/248 (1%) Frame = +1 Query: 640 SGRHSRVYFGRYNGR-EVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSFVA 816 +G+ V +G++ G+ VAIKM+ + + E +F E +++ L H +V Sbjct: 408 TGQFGVVKYGKWRGQYNVAIKMIRE-------GSMSEDEFIDEAKVMMNLSHEKLVQLYG 460 Query: 817 ACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGILHRD 996 C K IITEYMA G L +L + + P +L L++ D+ M YL S+ LHRD Sbjct: 461 VCTKQRPIFIITEYMANGCLLNFLRETQRRFQPAEL-LEMCKDVCEAMEYLESKQFLHRD 519 Query: 997 LKSENVLLGEDMSVKVADFGIS--CLESQCGSGKGFTGTYRWMAPEMIKEKNHTRKVDVY 1170 L + N L+ + VKV+DFG+S L+ + S G RW PE++ + K DV+ Sbjct: 520 LAARNCLVNDQGIVKVSDFGLSRYVLDDEYTSSMGSKFPVRWSPPEVLLYSKFSSKSDVW 579 Query: 1171 SFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATNPDK 1347 SFG+++WE+ + +P+ + V ++ R P + ++ CW ++ Sbjct: 580 SFGVLMWEVYSLGKMPYERFNNSETTEHV-IQGLRLYRPQQASERVYAIMYSCWHEKAEE 638 Query: 1348 RPQFDDIV 1371 RP F ++ Sbjct: 639 RPTFSALL 646
>Q9V3Q6:M3K7_DROME Mitogen-activated protein kinase kinase kinase 7 - Drosophila| melanogaster (Fruit fly) Length = 678 Score = 120 bits (301), Expect = 2e-26 Identities = 69/220 (31%), Positives = 113/220 (51%), Gaps = 4/220 (1%) Frame = +1 Query: 733 AAELERQFASEVALLLRLRHHNIVSFVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSV 912 A+ ++ EV L R++H NI++ +I E+ GGSL +LH + + Sbjct: 50 ASAEQKDIEKEVKQLSRVKHPNIIALHGISSYQQATYLIMEFAEGGSLHNFLHGKVKPAY 109 Query: 913 PIQLVLQLALDIARGMSYLHS---QGILHRDLKSENVLL-GEDMSVKVADFGISCLESQC 1080 + + A A G++YLH+ + ++HRD+K N+LL + ++K+ DFG +S Sbjct: 110 SLAHAMSWARQCAEGLAYLHAMTPKPLIHRDVKPLNLLLTNKGRNLKICDFGTVADKSTM 169 Query: 1081 GSGKGFTGTYRWMAPEMIKEKNHTRKVDVYSFGIVLWEILTALVPFSEMTPEQAAIAVAL 1260 + G+ WMAPE+ + +T K D++S+ IVLWE+L+ PF + Sbjct: 170 MTNN--RGSAAWMAPEVFEGSKYTEKCDIFSWAIVLWEVLSRKQPFKGIDNAYTIQWKIY 227 Query: 1261 KNARPPLPASCPVAMSHLISQCWATNPDKRPQFDDIVVVL 1380 K RPPL +CP + L++ CW T P+ RP IV V+ Sbjct: 228 KGERPPLLTTCPKRIEDLMTACWKTVPEDRPSMQYIVGVM 267
>P53670:LIMK2_RAT LIM domain kinase 2 - Rattus norvegicus (Rat)| Length = 638 Score = 120 bits (301), Expect = 2e-26 Identities = 77/232 (33%), Positives = 113/232 (48%), Gaps = 22/232 (9%) Frame = +1 Query: 739 ELERQFASEVALLLRLRHHNIVSFVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPI 918 E ++ F +EV ++ L H N++ F+ K ++TEY+ GG+L+ +L +P P Sbjct: 368 ETQKTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRNVDPF--PW 425 Query: 919 QLVLQLALDIARGMSYLHSQGILHRDLKSENVLLGEDMSVKVADFGISCL---------- 1068 Q ++ A IA GM+YLHS I+HRDL S N L+ D +V VADFG+S L Sbjct: 426 QQKVRFAKGIASGMAYLHSMCIIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRPPV 485 Query: 1069 -----------ESQCGSGKGFTGTYRWMAPEMIKEKNHTRKVDVYSFGIVLWEILTALVP 1215 +S G WMAPEM+ K++ VDV+SFGIVL EI+ + Sbjct: 486 EKAATKKRTLRKSDRKKRYTVVGNPYWMAPEMLNGKSYDETVDVFSFGIVLCEIIGQVYA 545 Query: 1216 FSEMTPEQAAIAVALKNA-RPPLPASCPVAMSHLISQCWATNPDKRPQFDDI 1368 + P + +K +P CP A L + C P+ RP F + Sbjct: 546 DPDCLPRTLDFGLNVKLFWEKFVPTDCPPAFFPLAAICCKLEPESRPAFSKL 597
>Q5R5V4:ILK_PONPY Integrin-linked protein kinase - Pongo pygmaeus (Orangutan)| Length = 452 Score = 120 bits (301), Expect = 2e-26 Identities = 76/246 (30%), Positives = 128/246 (52%), Gaps = 7/246 (2%) Frame = +1 Query: 667 GRYNGREVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSFVAACKKPPVF-- 840 GR+ G ++ +K++ + R F E L H N++ + AC+ PP Sbjct: 210 GRWQGNDIVVKVLKVRD----WSTRKSRDFNEECPRLRIFSHPNVLPVLGACQSPPAPHP 265 Query: 841 CIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGIL--HRDLKSENV 1014 +IT +M GSL LH+ V ++ ALD+ARGM++LH+ L L S +V Sbjct: 266 TLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMARGMAFLHTLEPLIPRHALNSRSV 325 Query: 1015 LLGEDMSVKVADFGISCLESQCGSGKGFTGTYRWMAPEMIKEK---NHTRKVDVYSFGIV 1185 ++ EDM+ +++ + QC G W+APE +++K + R D++SF ++ Sbjct: 326 MIDEDMTARISMADVK-FSFQC---PGRMYAPAWVAPEALQKKPEDTNIRSADMWSFAVL 381 Query: 1186 LWEILTALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATNPDKRPQFDD 1365 LWE++T VPF++++ + + VAL+ RP +P + L+ C +P KRP+FD Sbjct: 382 LWELVTREVPFADLSNMEIGMRVALEGLRPTIPPGISPHVCKLMKICMNEDPAKRPKFDM 441 Query: 1366 IVVVLE 1383 IV +LE Sbjct: 442 IVPILE 447
>Q13418:ILK_HUMAN Integrin-linked protein kinase - Homo sapiens (Human)| Length = 452 Score = 120 bits (301), Expect = 2e-26 Identities = 76/246 (30%), Positives = 128/246 (52%), Gaps = 7/246 (2%) Frame = +1 Query: 667 GRYNGREVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSFVAACKKPPVF-- 840 GR+ G ++ +K++ + R F E L H N++ + AC+ PP Sbjct: 210 GRWQGNDIVVKVLKVRD----WSTRKSRDFNEECPRLRIFSHPNVLPVLGACQSPPAPHP 265 Query: 841 CIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGIL--HRDLKSENV 1014 +IT +M GSL LH+ V ++ ALD+ARGM++LH+ L L S +V Sbjct: 266 TLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMARGMAFLHTLEPLIPRHALNSRSV 325 Query: 1015 LLGEDMSVKVADFGISCLESQCGSGKGFTGTYRWMAPEMIKEK---NHTRKVDVYSFGIV 1185 ++ EDM+ +++ + QC G W+APE +++K + R D++SF ++ Sbjct: 326 MIDEDMTARISMADVK-FSFQC---PGRMYAPAWVAPEALQKKPEDTNRRSADMWSFAVL 381 Query: 1186 LWEILTALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATNPDKRPQFDD 1365 LWE++T VPF++++ + + VAL+ RP +P + L+ C +P KRP+FD Sbjct: 382 LWELVTREVPFADLSNMEIGMKVALEGLRPTIPPGISPHVCKLMKICMNEDPAKRPKFDM 441 Query: 1366 IVVVLE 1383 IV +LE Sbjct: 442 IVPILE 447
>Q04589:FGFR1_RAT Basic fibroblast growth factor receptor 1 precursor - Rattus| norvegicus (Rat) Length = 822 Score = 120 bits (301), Expect = 2e-26 Identities = 80/263 (30%), Positives = 131/263 (49%), Gaps = 23/263 (8%) Frame = +1 Query: 685 EVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSFVAACKKPPVFCIITEYMA 864 +VA+KM+ + DA +L + + + +H NI++ + AC + +I EY + Sbjct: 510 KVAVKML----KSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYAS 565 Query: 865 GGSLRKYLHQQEP----------HSVPIQL----VLQLALDIARGMSYLHSQGILHRDLK 1002 G+LR+YL + P H+ QL ++ A +ARGM YL S+ +HRDL Sbjct: 566 KGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLA 625 Query: 1003 SENVLLGEDMSVKVADFGISCLESQCGSGKGFTG---TYRWMAPEMIKEKNHTRKVDVYS 1173 + NVL+ ED +K+ADFG++ K T +WMAPE + ++ +T + DV+S Sbjct: 626 ARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWS 685 Query: 1174 FGIVLWEILTALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATNPDKRP 1353 FG++LWEI T + P + + + R P++C + ++ CW P +RP Sbjct: 686 FGVLLWEIFTLGGSPNPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWNAVPSQRP 745 Query: 1354 QFD------DIVVVLEGYKEALD 1404 F D +V L +E LD Sbjct: 746 TFKQLVEDLDRIVALTSNQEYLD 768
>P29321:EPHA8_RAT Ephrin type-A receptor 8 - Rattus norvegicus (Rat)| Length = 372 Score = 120 bits (301), Expect = 2e-26 Identities = 88/259 (33%), Positives = 127/259 (49%), Gaps = 11/259 (4%) Frame = +1 Query: 640 SGRHSRVYFGRYN--GRE---VAIKMVSQPHEDDALAAELERQ-FASEVALLLRLRHHNI 801 SG V +GR G+ VAIK + + E +RQ F E A++ + H NI Sbjct: 10 SGESGEVCYGRLQVPGQRDVPVAIKALKAGY------TERQRQDFLREAAIMGQFDHPNI 63 Query: 802 VSFVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQG 981 + + + I+TEYM GSL +L + +QLV L + GM YL G Sbjct: 64 IRLEGVVTRGRLAMIVTEYMENGSLDAFLRTHDGQFTILQLVGMLK-GVGAGMRYLSDLG 122 Query: 982 ILHRDLKSENVLLGEDMSVKVADFGIS-CLESQCGSGKGFTG---TYRWMAPEMIKEKNH 1149 +HRDL + N+L+ + KV+DFG+S LE + G RW APE I + Sbjct: 123 YIHRDLAARNILVDGRLVCKVSDFGLSRALEDDPEAAYTTAGGKIPIRWTAPEAIAFRTF 182 Query: 1150 TRKVDVYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQC 1326 + DV+SFG+V+WE+L P+ MT Q I+ + R P P CP A+ L+ C Sbjct: 183 SSASDVWSFGVVMWEVLAYGERPYWNMT-NQDVISSVEEGYRLPAPMGCPRALHQLMLDC 241 Query: 1327 WATNPDKRPQFDDIVVVLE 1383 W + +RP+F +V VLE Sbjct: 242 WHKDRAQRPRFSHVVSVLE 260
>P53666:LIMK2_CHICK LIM domain kinase 2 - Gallus gallus (Chicken)| Length = 642 Score = 120 bits (300), Expect = 2e-26 Identities = 76/232 (32%), Positives = 113/232 (48%), Gaps = 22/232 (9%) Frame = +1 Query: 739 ELERQFASEVALLLRLRHHNIVSFVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPI 918 E ++ F +EV ++ L H N++ F+ K ++TEY+ GG+L+ +L +P P Sbjct: 368 ETQKTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRNADPF--PW 425 Query: 919 QLVLQLALDIARGMSYLHSQGILHRDLKSENVLLGEDMSVKVADFGISCL---------- 1068 Q + A IA GM+YLHS I+HRDL S N L+ D +V VADFG+S L Sbjct: 426 QQKVSFAKGIASGMAYLHSMCIIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKKPTL 485 Query: 1069 -----------ESQCGSGKGFTGTYRWMAPEMIKEKNHTRKVDVYSFGIVLWEILTALVP 1215 +S G WMAPEM+ +++ VD++SFGIVL EI+ + Sbjct: 486 EKPSAKKRTLRKSDRKKRYTVVGNPYWMAPEMLNGQSYDETVDIFSFGIVLCEIIGQVYA 545 Query: 1216 FSEMTPEQAAIAVALKNA-RPPLPASCPVAMSHLISQCWATNPDKRPQFDDI 1368 + P + +K +PA CP A L + C P+ RP F + Sbjct: 546 DPDCLPRTLDFGLNVKLFWEKFVPADCPPAFFPLAAICCRLEPESRPPFSKL 597
>P15127:INSR_RAT Insulin receptor precursor - Rattus norvegicus (Rat)| Length = 1383 Score = 120 bits (300), Expect = 2e-26 Identities = 81/260 (31%), Positives = 133/260 (51%), Gaps = 13/260 (5%) Frame = +1 Query: 688 VAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSFVAACKKPPVFCIITEYMAG 867 VA+K V+ E +L +E F +E +++ H++V + K ++ E MA Sbjct: 1055 VAVKTVN---ESASLRERIE--FLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAH 1109 Query: 868 GSLRKYLHQQEPHSV--------PIQLVLQLALDIARGMSYLHSQGILHRDLKSENVLLG 1023 G L+ +L P + +Q ++Q+ +IA GM+YL+++ +HRDL + N ++ Sbjct: 1110 GDLKSHLRSLRPDAENNPGRPPPTLQEMIQMTAEIADGMAYLNAKKFVHRDLAARNCMVA 1169 Query: 1024 EDMSVKVADFGISC----LESQCGSGKGFTGTYRWMAPEMIKEKNHTRKVDVYSFGIVLW 1191 D +VK+ DFG++ + GKG RWM+PE +K+ T D++SFG+VLW Sbjct: 1170 HDFTVKIGDFGMTRDIYETDYYRKGGKGLL-PVRWMSPESLKDGVFTASSDMWSFGVVLW 1228 Query: 1192 EILT-ALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATNPDKRPQFDDI 1368 EI + A P+ ++ EQ V P P +CP ++ L+ CW NP RP F +I Sbjct: 1229 EITSLAEQPYQGLSNEQVLKFVMDGGYLDP-PDNCPERLTDLMRMCWQFNPKMRPTFLEI 1287 Query: 1369 VVVLEGYKEALDNDPSFFLS 1428 V +L+ + SFF S Sbjct: 1288 VNLLKDDLHPSFPEVSFFYS 1307
>Q99J82:ILK_RAT Integrin-linked protein kinase - Rattus norvegicus (Rat)| Length = 452 Score = 120 bits (300), Expect = 2e-26 Identities = 76/246 (30%), Positives = 128/246 (52%), Gaps = 7/246 (2%) Frame = +1 Query: 667 GRYNGREVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSFVAACKKPPVF-- 840 GR+ G ++ +K++ + R F E L H N++ + AC+ PP Sbjct: 210 GRWQGNDIVVKVLKVRD----WSTRKSRDFNEECPRLRIFSHPNVLPVLGACQAPPAPHP 265 Query: 841 CIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGIL--HRDLKSENV 1014 +IT +M GSL LH+ V ++ ALD+ARGM++LH+ L L S +V Sbjct: 266 TLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMARGMAFLHTLEPLIPRHALNSRSV 325 Query: 1015 LLGEDMSVKVADFGISCLESQCGSGKGFTGTYRWMAPEMIKEK---NHTRKVDVYSFGIV 1185 ++ EDM+ +++ + QC G W+APE +++K + R D++SF ++ Sbjct: 326 MIDEDMTARISMADVK-FSFQC---PGRMYAPAWVAPEALQKKPEDTNRRSADMWSFAVL 381 Query: 1186 LWEILTALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATNPDKRPQFDD 1365 LWE++T VPF++++ + + VAL+ RP +P + L+ C +P KRP+FD Sbjct: 382 LWELVTREVPFADLSNMEIGMKVALEGLRPTIPPGISPHVCKLMKICMNEDPAKRPKFDM 441 Query: 1366 IVVVLE 1383 IV +LE Sbjct: 442 IVPILE 447
>O55222:ILK_MOUSE Integrin-linked protein kinase - Mus musculus (Mouse)| Length = 452 Score = 120 bits (300), Expect = 2e-26 Identities = 76/246 (30%), Positives = 128/246 (52%), Gaps = 7/246 (2%) Frame = +1 Query: 667 GRYNGREVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSFVAACKKPPVF-- 840 GR+ G ++ +K++ + R F E L H N++ + AC+ PP Sbjct: 210 GRWQGNDIVVKVLKVRD----WSTRKSRDFNEECPRLRIFSHPNVLPVLGACQAPPAPHP 265 Query: 841 CIITEYMAGGSLRKYLHQQEPHSVPIQLVLQLALDIARGMSYLHSQGIL--HRDLKSENV 1014 +IT +M GSL LH+ V ++ ALD+ARGM++LH+ L L S +V Sbjct: 266 TLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMARGMAFLHTLEPLIPRHALNSRSV 325 Query: 1015 LLGEDMSVKVADFGISCLESQCGSGKGFTGTYRWMAPEMIKEK---NHTRKVDVYSFGIV 1185 ++ EDM+ +++ + QC G W+APE +++K + R D++SF ++ Sbjct: 326 MIDEDMTARISMADVK-FSFQC---PGRMYAPAWVAPEALQKKPEDTNRRSADMWSFAVL 381 Query: 1186 LWEILTALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATNPDKRPQFDD 1365 LWE++T VPF++++ + + VAL+ RP +P + L+ C +P KRP+FD Sbjct: 382 LWELVTREVPFADLSNMEIGMKVALEGLRPTIPPGISPHVCKLMKICMNEDPAKRPKFDM 441 Query: 1366 IVVVLE 1383 IV +LE Sbjct: 442 IVPILE 447
>P23049:SEA_AVIET Tyrosine-protein kinase transforming protein SEA - Avian| erythroblastosis virus (strain S13) Length = 370 Score = 119 bits (299), Expect = 3e-26 Identities = 73/231 (31%), Positives = 119/231 (51%), Gaps = 11/231 (4%) Frame = +1 Query: 751 QFASEVALLLRLRHHNIVSFVAAC-KKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLV 927 +F E L+ H ++S + C + + ++ YM G LR ++ QE S ++ + Sbjct: 105 EFLREGILMKGFHHPQVLSLLGVCLPRHGLPLVVLPYMRHGDLRHFVRAQE-RSPTVKEL 163 Query: 928 LQLALDIARGMSYLHSQGILHRDLKSENVLLGEDMSVKVADFGISCLESQCGSGKGFTG- 1104 + L +A GM YL + +HRDL + N +L E ++VKVADFG+ ++ GK + Sbjct: 164 IGFGLQVALGMEYLAQKKFVHRDLAARNCMLDETLTVKVADFGL----ARDVFGKEYYSI 219 Query: 1105 --------TYRWMAPEMIKEKNHTRKVDVYSFGIVLWEILT-ALVPFSEMTPEQAAIAVA 1257 RWMA E ++ + T K DV+SFG+++WE+LT P+ E+ P A Sbjct: 220 RQHRHAKLPVRWMALESLQTQKFTTKSDVWSFGVLMWELLTRGASPYPEVDPYDMA-RYL 278 Query: 1258 LKNARPPLPASCPVAMSHLISQCWATNPDKRPQFDDIVVVLEGYKEALDND 1410 L+ R P P CP + ++ CWA P++RP F +V LE +L+ + Sbjct: 279 LRGRRLPQPQPCPDTLYGVMLSCWAPTPEERPSFSGLVCELERVLASLEGE 329
>Q3SZJ2:RIPK2_BOVIN Receptor-interacting serine/threonine-protein kinase 2 - Bos taurus| (Bovine) Length = 540 Score = 119 bits (299), Expect = 3e-26 Identities = 85/252 (33%), Positives = 125/252 (49%), Gaps = 19/252 (7%) Frame = +1 Query: 685 EVAIKMVSQPHEDDALAAELERQFASEVALLLRLRHHNIVSFVAACKKPPVFCIITEYMA 864 +VA+K + H L E +L + R I+ + C +P I+TEYM Sbjct: 43 QVAVKHL---HIHSPLLDSERNDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMP 99 Query: 865 GGSLRKYLHQQ-EPHSVPIQLVLQLALDIARGMSYLHSQG--ILHRDLKSENVLLGEDMS 1035 GSL + LH++ E VP L ++ +IA G++YLH+ +LH DLK++N+LL + Sbjct: 100 NGSLNELLHRKIEYPDVPWPLRFRILHEIALGVNYLHNMNPPLLHHDLKTQNILLDNEFH 159 Query: 1036 VKVADFGISCLE----SQCGSGKGFT--GTYRWMAPEMIKEKNHTR---KVDVYSFGIVL 1188 VK+ADFG+S SQ S K GT +M PE + R K D+YS+ I++ Sbjct: 160 VKIADFGLSKWRMMSLSQSRSSKSAPEGGTIVYMPPENYEPGQKARASVKHDIYSYAIII 219 Query: 1189 WEILTALVPFSEMTPEQAAIAVALKNARP-----PLPASCP--VAMSHLISQCWATNPDK 1347 WE+L+ PF ++T + + RP LP P M LI WA NPD+ Sbjct: 220 WEVLSRKQPFEDVTNPLQIMYSVSQGHRPDTNEESLPFDIPHRALMISLIESGWAQNPDE 279 Query: 1348 RPQFDDIVVVLE 1383 RP F ++ LE Sbjct: 280 RPSFLKCLIELE 291
>P22455:FGFR4_HUMAN Fibroblast growth factor receptor 4 precursor - Homo sapiens (Human)| Length = 802 Score = 119 bits (299), Expect = 3e-26 Identities = 76/250 (30%), Positives = 123/250 (49%), Gaps = 18/250 (7%) Frame = +1 Query: 688 VAIKMVSQPHEDDALAAELERQFASEVALLLRL-RHHNIVSFVAACKKPPVFCIITEYMA 864 VA+KM+ D LA SE+ ++ + RH NI++ + C + +I E A Sbjct: 500 VAVKMLKDNASDKDLA-----DLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAA 554 Query: 865 GGSLRKYLHQQEPHSVPIQ--------------LVLQLALDIARGMSYLHSQGILHRDLK 1002 G+LR++L + P + +++ A +ARGM YL S+ +HRDL Sbjct: 555 KGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLA 614 Query: 1003 SENVLLGEDMSVKVADFGISCLESQCGSGKGFTG---TYRWMAPEMIKEKNHTRKVDVYS 1173 + NVL+ ED +K+ADFG++ K + +WMAPE + ++ +T + DV+S Sbjct: 615 ARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWS 674 Query: 1174 FGIVLWEILTALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATNPDKRP 1353 FGI+LWEI T P + ++ + R P CP + L+ +CW P +RP Sbjct: 675 FGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRP 734 Query: 1354 QFDDIVVVLE 1383 F +V L+ Sbjct: 735 TFKQLVEALD 744
>O13147:EPHB3_DANRE Ephrin type-B receptor 3 - Danio rerio (Zebrafish) (Brachydanio| rerio) Length = 500 Score = 119 bits (299), Expect = 3e-26 Identities = 71/221 (32%), Positives = 112/221 (50%), Gaps = 7/221 (3%) Frame = +1 Query: 748 RQFASEVALLLRLRHHNIVSFVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPIQLV 927 R F SE +++ + H N++ + I+TE+M G+L +L + QLV Sbjct: 231 RDFLSEASIMGQFDHPNVIHLEGVLTRSCPVLIVTEFMENGALDSFLRLNDGRFTVTQLV 290 Query: 928 LQLALDIARGMSYLHSQGILHRDLKSENVLLGEDMSVKVADFGISCLESQCGSGKGFTGT 1107 L IA GM YL +HRDL + NVL+ ++ KV+DFG+S S +T + Sbjct: 291 GMLR-GIAAGMKYLSDMNYVHRDLAARNVLVNSNLVCKVSDFGLSRFLDDNSSDPTYTSS 349 Query: 1108 ------YRWMAPEMIKEKNHTRKVDVYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKN 1266 RW APE I + T DV+S+GIV+WE+++ P+ +M+ + AV ++ Sbjct: 350 LGGKIPIRWTAPEAIAFRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVMNAVE-QD 408 Query: 1267 ARPPLPASCPVAMSHLISQCWATNPDKRPQFDDIVVVLEGY 1389 R P P CP + L+ +CW + RP+F IV L+ + Sbjct: 409 YRLPPPMDCPAVLHQLMLECWVKERNMRPRFGQIVSTLDKF 449
>P33497:RYK_AVIR3 Tyrosine-protein kinase transforming protein RYK - Avian retrovirus| RPL30 Length = 442 Score = 119 bits (298), Expect = 4e-26 Identities = 84/284 (29%), Positives = 136/284 (47%), Gaps = 21/284 (7%) Frame = +1 Query: 613 KARDPGRFASGRHSRVYFGRYNGREVAIKMVSQPHEDDALAAELERQFASEVALLLRLRH 792 K G F S R+ ++VA+K + D+ E+E +F SE A + H Sbjct: 49 KVLGEGEFGSVMEGRLSQPEGTPQKVAVKTMKL---DNFSHREIE-EFLSEAACIKDFDH 104 Query: 793 HNIVSFVAAC-----KKPPVFCIITEYMAGGSLRKYLHQQE----PHSVPIQLVLQLALD 945 N++ + C ++ P ++ +M G L +L + P VP+Q++L+ +D Sbjct: 105 PNVIKLLGVCIELSSQQIPKPMVVLPFMKYGDLHSFLLRSRLEMAPQFVPLQMLLKFMVD 164 Query: 946 IARGMSYLHSQGILHRDLKSENVLLGEDMSVKVADFGISCLESQCGSGKGFTGTY----- 1110 IA GM YL S+ LHRDL + N +L +DM+V VADFG+ S K ++G Y Sbjct: 165 IALGMEYLSSRQFLHRDLAARNCMLRDDMTVCVADFGL--------SKKIYSGDYYRQGR 216 Query: 1111 ------RWMAPEMIKEKNHTRKVDVYSFGIVLWEILT-ALVPFSEMTPEQAAIAVALKNA 1269 +W+A E + ++ +T K DV++FG+ +WEI T + P+ + + Sbjct: 217 IAKMPVKWIAIESLADRVYTTKSDVWAFGVTMWEIATRGMTPYPGVQNHE-IYEYLFHGQ 275 Query: 1270 RPPLPASCPVAMSHLISQCWATNPDKRPQFDDIVVVLEGYKEAL 1401 R P +C + ++S CW P RP F + V LE E+L Sbjct: 276 RLKKPENCLDELYDIMSSCWRAEPADRPTFSQLKVHLEKLLESL 319
>O54785:LIMK2_MOUSE LIM domain kinase 2 - Mus musculus (Mouse)| Length = 638 Score = 119 bits (298), Expect = 4e-26 Identities = 76/232 (32%), Positives = 113/232 (48%), Gaps = 22/232 (9%) Frame = +1 Query: 739 ELERQFASEVALLLRLRHHNIVSFVAACKKPPVFCIITEYMAGGSLRKYLHQQEPHSVPI 918 E ++ F +EV ++ L H N++ F+ K ++TEY+ GG+L+ +L +P P Sbjct: 368 ETQKTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRSVDPF--PW 425 Query: 919 QLVLQLALDIARGMSYLHSQGILHRDLKSENVLLGEDMSVKVADFGISCL---------- 1068 Q ++ A I+ GM+YLHS I+HRDL S N L+ D +V VADFG+S L Sbjct: 426 QQKVRFAKGISSGMAYLHSMCIIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRPPV 485 Query: 1069 -----------ESQCGSGKGFTGTYRWMAPEMIKEKNHTRKVDVYSFGIVLWEILTALVP 1215 +S G WMAPEM+ K++ VDV+SFGIVL EI+ + Sbjct: 486 EKATTKKRTLRKSDRKKRYTVVGNPYWMAPEMLNGKSYDETVDVFSFGIVLCEIIGQVYA 545 Query: 1216 FSEMTPEQAAIAVALKNA-RPPLPASCPVAMSHLISQCWATNPDKRPQFDDI 1368 + P + +K +P CP A L + C P+ RP F + Sbjct: 546 DPDCLPRTLDFGLNVKLFWEKFVPTDCPPAFFPLAAICCKLEPESRPAFSKL 597
>O42127:FGFR3_XENLA Fibroblast growth factor receptor 3 precursor - Xenopus laevis| (African clawed frog) Length = 802 Score = 119 bits (298), Expect = 4e-26 Identities = 76/250 (30%), Positives = 126/250 (50%), Gaps = 18/250 (7%) Frame = +1 Query: 688 VAIKMVSQPHEDDALAAELERQFASEVALLLRL-RHHNIVSFVAACKKPPVFCIITEYMA 864 VA+KM+ +DDA +L SE+ ++ + +H NI++ + AC + ++ EY + Sbjct: 495 VAVKML----KDDATDKDLS-DLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVLVEYAS 549 Query: 865 GGSLRKYLHQQEPHSVPIQL--------------VLQLALDIARGMSYLHSQGILHRDLK 1002 GSLR+YL + P + ++ A +ARGM YL SQ +HRDL Sbjct: 550 KGSLREYLKARRPPGMDYSFDACKIPAEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLA 609 Query: 1003 SENVLLGEDMSVKVADFGISCLESQCGSGKGFTG---TYRWMAPEMIKEKNHTRKVDVYS 1173 + NVL+ +D +K+ADFG++ K T +WMAPE + ++ +T DV+S Sbjct: 610 ARNVLVTDDNVMKIADFGLARDIHNIDYYKKTTNGRLPVKWMAPEALFDRIYTHHSDVWS 669 Query: 1174 FGIVLWEILTALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATNPDKRP 1353 +G++LWEI T P + + + R PA+C + ++ +CW P +RP Sbjct: 670 YGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHELYMIMRECWHAVPSQRP 729 Query: 1354 QFDDIVVVLE 1383 F +V L+ Sbjct: 730 AFKQLVEDLD 739
>P18461:FGFR2_CHICK Fibroblast growth factor receptor 2 precursor - Gallus gallus| (Chicken) Length = 823 Score = 119 bits (298), Expect = 4e-26 Identities = 81/265 (30%), Positives = 132/265 (49%), Gaps = 18/265 (6%) Frame = +1 Query: 688 VAIKMVSQPHEDDALAAELERQFASEVALLLRL-RHHNIVSFVAACKKPPVFCIITEYMA 864 VA+KM+ +DDA +L SE+ ++ + +H NI++ + AC + +I EY + Sbjct: 516 VAVKML----KDDATEKDLS-DLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYAS 570 Query: 865 GGSLRKYLHQQEP----HSVPIQLV----------LQLALDIARGMSYLHSQGILHRDLK 1002 G+LR+YL + P +S I V + +ARGM YL SQ +HRDL Sbjct: 571 KGNLREYLRARRPPGMEYSFDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLA 630 Query: 1003 SENVLLGEDMSVKVADFGISCLESQCGSGKGFTG---TYRWMAPEMIKEKNHTRKVDVYS 1173 + NVL+ E+ +K+ADFG++ + K T +WMAPE + ++ +T + DV+S Sbjct: 631 ARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWS 690 Query: 1174 FGIVLWEILTALVPFSEMTPEQAAIAVALKNARPPLPASCPVAMSHLISQCWATNPDKRP 1353 FG+++WEI T P + + + R PA+C + ++ CW P +RP Sbjct: 691 FGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWQAVPSQRP 750 Query: 1354 QFDDIVVVLEGYKEALDNDPSFFLS 1428 F +V L+ N+ LS Sbjct: 751 TFKQLVEDLDRILTLTTNEEYLDLS 775 Database: uniprot_sprot.fasta.out Posted date: Jul 19, 2007 5:58 PM Number of letters in database: 100,686,439 Number of sequences in database: 274,295 Lambda K H 0.318 0.134 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 274295 Number of Hits to DB: 288,177,722 Number of extensions: 6136429 Number of successful extensions: 24584 Number of sequences better than 10.0: 2633 Number of HSP's gapped: 20725 Number of HSP's successfully gapped: 2763 Length of query: 605 Length of database: 100,686,439 Length adjustment: 119 Effective length of query: 486 Effective length of database: 68,045,334 Effective search space: 33070032324 Effective search space used: 33070032324 Neighboring words threshold: 12 Window for multiple hits: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)
