>Q91WF7:SAC3_MOUSE SAC domain-containing protein 3 - Mus musculus (Mouse)|
          Length = 907
 Score =  398 bits (1022), Expect = e-110
 Identities = 239/617 (38%), Positives = 356/617 (57%), Gaps = 45/617 (7%)
 Frame = +2

Query: 407  LQKFRLYETRSKFYLVGRDKSRTLWRVLKIDRLESTDLGIQEDPTSYTENECQELLWRIH 586
            +QK  LYETR++++LVG + + T +RVLKIDR E  DL + +D   YT+ E +ELL R+ 
Sbjct: 12   VQKLVLYETRARYFLVGSNHAETKYRVLKIDRTEPKDLVVIDDRHVYTQQEVRELLGRLD 71

Query: 587  EGNRL------TGGLKFVTKCYGIIGFMKFLGPYYMVVITRRRKVGTICGHDIYSIGKSE 748
             GNR       + GL      +G++GF++FL  YY+V+IT+RRK+  I GH IY I  + 
Sbjct: 72   LGNRTKMSQKGSSGLFRAVSAFGVVGFVRFLEGYYIVLITKRRKMADIGGHAIYKIEDTS 131

Query: 749  MIAIPCPIVCPNVANSRDENRYKRLLCSVDLTKDFFFSYSYNIMRSLQKNIN-------- 904
            MI IP   V     +  DE RY R+  +VDL+ +F+FSYSY++  SLQ N+         
Sbjct: 132  MIYIPNDSVR---ISHPDEARYLRIFQNVDLSSNFYFSYSYDLSHSLQYNLTVLRMPLEM 188

Query: 905  -DKNTGHVVYETM--------------------------FVWNEFLTRAMRNHLKNTDWT 1003
                T     E+                           +VWN  L   ++N + + DW 
Sbjct: 189  LKSETSKACQESFDIFEDEGLITQGGSGVFGISSEPYMKYVWNGELLDIIKNTV-HRDWL 247

Query: 1004 VALVHGFFKQSKLAVSGKDFWLTLIARRSRHFAGTRFMKRGVNEKGRVANDVETEQIVFE 1183
            + ++HGF  QSKL + G+  ++TLIARRS  FAGTRF+KRG N +G VAN+VETEQI+ +
Sbjct: 248  LYIIHGFCGQSKLLIYGRPVYVTLIARRSSRFAGTRFLKRGANCEGDVANEVETEQILCD 307

Query: 1184 DTPDDIPS-QITSVVQHRGSIPLVWFQETSRLNIRPEITL-KSDVDYKATRLHFENLVLR 1357
             +     +   +S VQ RGS+PL W Q+ S +  +P ITL ++D       LHF+ ++ R
Sbjct: 308  ASVMSFTAGSYSSYVQVRGSVPLFWSQDISTMMPKPPITLDQADPFAHVAALHFDQMLQR 367

Query: 1358 YGNPIVILNLIKTREKKPRESLLRAEFAKAIHYINKGLPDDERLKFLHMDLSKLSRRKGT 1537
            +G+PI+ILNL+K REK+  E +L  E   A+ Y+N+ LP +  + ++  D++K ++ K  
Sbjct: 368  FGSPIIILNLVKEREKRKHERILSEELVAAVTYLNQFLPPEHTIVYIPWDMAKYTKSKLC 427

Query: 1538 NVLGLLNKVASDVLELTDLLHCEITTSSKPLDASSGQGSSDIKRNDDFCAATMVPL-LLQ 1714
            NVL  LN +A  V++ T          ++P D+       D K N+      ++P   LQ
Sbjct: 428  NVLDRLNVIAESVVKKTGFF------VNRP-DSYCSILRPDEKWNE--LGGHVIPTGRLQ 478

Query: 1715 KGVLRTNCIDCLDRTNVAQFAYGLAALGRQLHVLKLTEEPKIDLHDPLADDLMDFYERMG 1894
             G+LRTNC+DCLDRTN AQF  G  AL  QL+ L L ++P +           + YE  G
Sbjct: 479  TGILRTNCVDCLDRTNTAQFMVGKCALAYQLYSLGLIDKPNLQFDTDAVRLFEELYEDHG 538

Query: 1895 DTLAIQYGGSAAHNKIFCEQR-GQWKAATQSQEFLRTLQRYYNNAYTDPEKQDAINVFLG 2071
            DTL++QYGGS   +++   ++   W     S++ ++TL RYY+NA++D ++QD+IN+FLG
Sbjct: 539  DTLSLQYGGSQLVHRVKTYRKIAPW--TQHSKDIMQTLSRYYSNAFSDADRQDSINLFLG 596

Query: 2072 HFQPQQGKPPLWKLDSD 2122
             F P +GKP LW+L +D
Sbjct: 597  VFHPTEGKPHLWELPTD 613

>Q92562:SAC3_HUMAN SAC domain-containing protein 3 - Homo sapiens (Human)|
          Length = 907

 Score =  395 bits (1016), Expect = e-109
 Identities = 237/617 (38%), Positives = 356/617 (57%), Gaps = 45/617 (7%)
 Frame = +2

Query: 407  LQKFRLYETRSKFYLVGRDKSRTLWRVLKIDRLESTDLGIQEDPTSYTENECQELLWRIH 586
            +QK  LYETR++++LVG + + T +RVLKIDR E  DL I +D   YT+ E +ELL R+ 
Sbjct: 12   VQKLVLYETRARYFLVGSNNAETKYRVLKIDRTEPKDLVIIDDRHVYTQQEVRELLGRLD 71

Query: 587  EGNRL------TGGLKFVTKCYGIIGFMKFLGPYYMVVITRRRKVGTICGHDIYSIGKSE 748
             GNR       + GL      +G++GF++FL  YY+V+IT+RRK+  I GH IY +  + 
Sbjct: 72   LGNRTKMGQKGSSGLFRAVSAFGVVGFVRFLEGYYIVLITKRRKMADIGGHAIYKVEDTN 131

Query: 749  MIAIPCPIVCPNVANSRDENRYKRLLCSVDLTKDFFFSYSYNIMRSLQKNIN-------- 904
            MI IP   V        DE RY R+  +VDL+ +F+FSYSY++  SLQ N+         
Sbjct: 132  MIYIPNDSVR---VTHPDEARYLRIFQNVDLSSNFYFSYSYDLSHSLQYNLTVLRMPLEM 188

Query: 905  -------DKNTGHVVYET--------------------MFVWNEFLTRAMRNHLKNTDWT 1003
                   ++     ++E                      +VWN  L   +++ + + DW 
Sbjct: 189  LKSEMTQNRQESFDIFEDEGLITQGGSGVFGICSEPYMKYVWNGELLDIIKSTV-HRDWL 247

Query: 1004 VALVHGFFKQSKLAVSGKDFWLTLIARRSRHFAGTRFMKRGVNEKGRVANDVETEQIVFE 1183
            + ++HGF  QSKL + G+  ++TLIARRS  FAGTRF+KRG N +G VAN+VETEQI+ +
Sbjct: 248  LYIIHGFCGQSKLLIYGRPVYVTLIARRSSKFAGTRFLKRGANCEGDVANEVETEQILCD 307

Query: 1184 DTPDDIPS-QITSVVQHRGSIPLVWFQETSRLNIRPEITL-KSDVDYKATRLHFENLVLR 1357
             +     +   +S VQ RGS+PL W Q+ S +  +P ITL ++D       LHF+ +  R
Sbjct: 308  ASVMSFTAGSYSSYVQVRGSVPLYWSQDISTMMPKPPITLDQADPFAHVAALHFDQMFQR 367

Query: 1358 YGNPIVILNLIKTREKKPRESLLRAEFAKAIHYINKGLPDDERLKFLHMDLSKLSRRKGT 1537
            +G+PI+ILNL+K REK+  E +L  E   A+ Y+N+ LP +  + ++  D++K ++ K  
Sbjct: 368  FGSPIIILNLVKEREKRKHERILSEELVAAVTYLNQFLPPEHTIVYIPWDMAKYTKSKLC 427

Query: 1538 NVLGLLNKVASDVLELTDLLHCEITTSSKPLDASSGQGSSDIKRNDDFCAATMVPL-LLQ 1714
            NVL  LN +A  V++ T          ++P D+       D K N+      ++P   LQ
Sbjct: 428  NVLDRLNVIAESVVKKTGFF------VNRP-DSYCSILRPDEKWNE--LGGCVIPTGRLQ 478

Query: 1715 KGVLRTNCIDCLDRTNVAQFAYGLAALGRQLHVLKLTEEPKIDLHDPLADDLMDFYERMG 1894
             G+LRTNC+DCLDRTN AQF  G  AL  QL+ L L ++P +           + YE  G
Sbjct: 479  TGILRTNCVDCLDRTNTAQFMVGKCALAYQLYSLGLIDKPNLQFDTDAVRLFEELYEDHG 538

Query: 1895 DTLAIQYGGSAAHNKIFCEQR-GQWKAATQSQEFLRTLQRYYNNAYTDPEKQDAINVFLG 2071
            DTL++QYGGS   +++   ++   W     S++ ++TL RYY+NA++D ++QD+IN+FLG
Sbjct: 539  DTLSLQYGGSQLVHRVKTYRKIAPW--TQHSKDIMQTLSRYYSNAFSDADRQDSINLFLG 596

Query: 2072 HFQPQQGKPPLWKLDSD 2122
             F P +GKP LW+L +D
Sbjct: 597  VFHPTEGKPHLWELPTD 613

>P42837:FIG4_YEAST Polyphosphoinositide phosphatase - Saccharomyces cerevisiae (Baker's|
            yeast)
          Length = 879

 Score =  378 bits (971), Expect = e-104
 Identities = 226/596 (37%), Positives = 333/596 (55%), Gaps = 26/596 (4%)
 Frame = +2

Query: 413  KFRLYETRSKFYLVGRDKSRTLWRVLKID-RLESTDLGIQEDPTSYTENECQELLWRIHE 589
            K+ LYET+ + Y+VG +K  T++R+L+ID  +   +L + ED   +T NE   +L  + E
Sbjct: 32   KYTLYETKDRMYIVGSNKRETMFRILEIDLTVPRGELTVLEDNVFFTRNEIMNVLASLEE 91

Query: 590  GNRLTGGLKFVTKCYGIIGFMKFLGPYYMVVITRRRKVGTICGHDIYSIGKSEMIAIPCP 769
                  GL      YG++GF+KF   YY++++T+  +V  I GH IY I   ++I I   
Sbjct: 92   ATE--DGLHKKITGYGLLGFIKFTCWYYLIMVTKYSQVAVIGGHGIYHIDGIDIIPITNN 149

Query: 770  IVCPNVANSRDENRYKRLLCSVDLTKDFFFSYSYNIMRSLQKNINDKNT----------- 916
               P    S DE R   +   +DLTK F+FSY+Y+I  +LQ NI  +             
Sbjct: 150  YKKPE--KSSDEARLLNIFKDLDLTKTFYFSYTYDITNTLQTNILREKLKAVDRCDITIP 207

Query: 917  -GHVVYETMFVWNEFLTRAMRNHLKNT-DWTVALVHGFFKQSKLAVSGKDFWLTLIARRS 1090
             G   Y  MFVWN  L   +   +    DW   ++HGF  Q  ++V GK  ++TLIARRS
Sbjct: 208  CGITDYNEMFVWNNNLLSPIFACIDTVFDWFQCIIHGFIDQVNVSVLGKSIYITLIARRS 267

Query: 1091 RHFAGTRFMKRGVNEKGRVANDVETEQIVFED--TPDDIP-------SQITSVVQHRGSI 1243
             HFAG RF+KRGVN KG VAN+VETEQIV +   TP   P        + TS VQHRGSI
Sbjct: 268  HHFAGARFLKRGVNNKGHVANEVETEQIVTDMILTPFHQPGNGFFDSDRYTSFVQHRGSI 327

Query: 1244 PLVWFQETSRLNIRPEITLK-SDVDYKATRLHFENLVLRY-GNPIVILNLIKTREKKPRE 1417
            PL W Q+ S L  +P I +   D  +    LHF+NL  RY G  I ILNLIKT+EK PRE
Sbjct: 328  PLYWTQDASNLTTKPPIRINVVDPFFSPAALHFDNLFQRYGGGTIQILNLIKTKEKTPRE 387

Query: 1418 SLLRAEFAKAIHYINKGLPDDERLKFLHMDLSKLSRRKGTNVLGLLNKVASDVLELTDLL 1597
            + L  EF + I Y+N+ LP  ++L +   D+S+ S++ G  V+  L K A + +  T + 
Sbjct: 388  TKLLWEFEQCIDYLNEFLPTLKKLDYTSWDMSRASKQDGQGVIEFLEKYAVNTVTTTGIF 447

Query: 1598 HCEITTSSKPLDASSGQGSSDIKRNDDFCAATMVPLLLQKGVLRTNCIDCLDRTNVAQFA 1777
            H                         DF +       +Q+G+ R+NCIDCLDRTN AQF 
Sbjct: 448  H----------------------NGPDFASTK-----IQEGICRSNCIDCLDRTNAAQFV 480

Query: 1778 YGLAALGRQLHVLKLTEEPKIDLHDPLADDLMDFYERMGDTLAIQYGGSAAHNKIFCEQR 1957
             G  ALG QL  L + +   ++    + + L + +  +GDT+A+QYGGS   N +   ++
Sbjct: 481  IGKRALGCQLKSLGIIDNSYLEYDSDIVNILTELFHDLGDTIALQYGGSHLVNTMETYRK 540

Query: 1958 -GQWKAATQSQEFLRTLQRYYNNAYTDPEKQDAINVFLGHFQPQQGKPPLWKLDSD 2122
              QW  ++ S++ + +++R+Y+N++ D ++QDAIN+FLGH+  ++G P LW++++D
Sbjct: 541  INQW--SSHSRDMIESIKRFYSNSFVDAQRQDAINLFLGHYSWREGFPSLWEMNTD 594

>P32368:RSD1_YEAST Recessive suppressor of secretory defect - Saccharomyces cerevisiae|
            (Baker's yeast)
          Length = 623

 Score =  162 bits (411), Expect = 6e-39
 Identities = 133/513 (25%), Positives = 231/513 (45%), Gaps = 14/513 (2%)
 Frame = +2

Query: 587  EGNRLTGGLKF-----VTKCYGIIGFMKFLGPYYMVVITRRRKVGTICGHDIYSIGKSEM 751
            +G R+ G  +F     V K   ++GF+K     Y ++     + G   GH  Y + +  +
Sbjct: 36   QGVRVLGAEEFPVQGEVVKIASLMGFIKLKLNRYAIIANTVEETGRFNGHVFYRVLQHSI 95

Query: 752  IAIPCPIVCPNVANSRDENRYKRLLCSVDLTKDFFFSYSYNIMRSLQKNINDKNTGHVVY 931
            ++        N     +E  Y +LL        F+FSY+Y++  SLQ+N  +K      +
Sbjct: 96   VSTKF-----NSRIDSEEAEYIKLLELHLKNSTFYFSYTYDLTNSLQRN--EKVGPAASW 148

Query: 932  ETM---FVWNEFLTRAMRNHLKNT----DWTVALVHGFFKQSKLAVSGKDFWLTLIARRS 1090
            +T    F WN +LT  +RN          +   +++G+ K     ++     L LI RRS
Sbjct: 149  KTADERFFWNHYLTEDLRNFAHQDPRIDSFIQPVIYGYAKTVDAVLNATPIVLGLITRRS 208

Query: 1091 RHFAGTRFMKRGVNEKGRVANDVETEQIVFEDTPDDIPSQITSVVQHRGSIPLVWFQETS 1270
               AGTR+ +RGV++ G V N  ETEQI+  + P+     + S +Q RGS+P+ W  E +
Sbjct: 209  IFRAGTRYFRRGVDKDGNVGNFNETEQILLAENPESEKIHVFSFLQTRGSVPIYW-AEIN 267

Query: 1271 RLNIRPEITLKSDVDYKATRLHFENLVLRYGNPIVILNLIKTREKKPRESLLRAEFAKAI 1450
             L  +P + L  +    AT+ HF+     YG+  ++ NL+    +K  E  ++  +   +
Sbjct: 268  NLKYKPNLVL-GENSLDATKKHFDQQKELYGDNYLV-NLV---NQKGHELPVKEGYESVV 322

Query: 1451 HYINKGLPDDERLKFLHMDLSKLSRR-KGTNVLGLLNKVASDVLELTDLLHCEITTSSKP 1627
            H +N     D ++ +++ D     R+ +   V  L++ +    L   D  H  I ++   
Sbjct: 323  HALN-----DPKIHYVYFDFHHECRKMQWHRVKLLIDHLEKLGLSNEDFFHKVIDSNGNT 377

Query: 1628 LDASSGQGSSDIKRNDDFCAATMVPLLLQKGVLRTNCIDCLDRTNVAQFAYGLAALGRQL 1807
            ++  + Q S                      V+RTNC+DCLDRTNV Q       L ++ 
Sbjct: 378  VEIVNEQHS----------------------VVRTNCMDCLDRTNVVQSVLAQWVLQKEF 415

Query: 1808 HVLKLTEEPKI-DLHDPLADDLMDFYERMGDTLAIQYGGSAAHNKIFCEQRGQWKAATQS 1984
                +       + + PL     + +    D +++ Y G+ A    F  + G+       
Sbjct: 416  ESADVVATGSTWEDNAPLLTSYQNLWADNADAVSVAYSGTGALKTDF-TRTGKRTRLGAF 474

Query: 1985 QEFLRTLQRYYNNAYTDPEKQDAINVFLGHFQP 2083
             +FL +  RYY N +TD  +QD+ ++FLG F+P
Sbjct: 475  NDFLNSASRYYQNNWTDGPRQDSYDLFLGGFRP 507

>O18964:SYNJ1_BOVIN Synaptojanin-1 - Bos taurus (Bovine)|
          Length = 1324

 Score =  133 bits (334), Expect = 5e-30
 Identities = 138/511 (27%), Positives = 230/511 (45%), Gaps = 17/511 (3%)
 Frame = +2

Query: 587  EGNRLTGGLKFVTKCYGIIGFMKF-LGP---YYMVVITRRRKVGTICGHDIYSIGKSEMI 754
            E   + G    V   YG++G ++  LG    +Y+V++T    VG I   +++ +  +E I
Sbjct: 45   EKEAIKGTYSKVLDAYGLLGVLRLNLGDIMLHYLVLVTGCMSVGKIQESEVFRVTSTEFI 104

Query: 755  AIPCPIVCPNVANSRDENRYKRLLCSVDLTKDFFFSYS---------YNIMRSLQKNIND 907
            ++          +S DE+R   +   ++ + +F+F++S          N  RSLQ++  D
Sbjct: 105  SLR--------VDSSDEDRISEVRKVLN-SGNFYFAWSASGVSLDLSLNAHRSLQEHTTD 155

Query: 908  KNTGHVVYETMFVWNEFLTRAMRNHLKN-TDWTVALVHGFFKQSKLAVSGKDFWLTLIAR 1084
                       F WN+ L   ++++  N  DW + L+ G  +   +  + K     LI+R
Sbjct: 156  NR---------FSWNQSLHLHLKHYGVNCADWLLRLMCGGVEIRTIYAAHKQAKACLISR 206

Query: 1085 RSRHFAGTRFMKRGVNEKGRVANDVETEQIVFEDTPDDIPSQITSVVQHRGSIPLVWFQE 1264
             S   AGTRF  RG N+ G VAN VETEQ+V+ D        ++S +Q RGS+PL W Q 
Sbjct: 207  LSCERAGTRFNVRGTNDDGHVANFVETEQVVYLD------DSVSSFIQIRGSVPLFWEQP 260

Query: 1265 TSRL-NIRPEITLKSDVDYKATRLHFENLVLRYGNPIVILNLIKTREKKPRESLLRAEFA 1441
              ++ + R  ++   + +  A   HF  L   YG  I++ NL+ ++E    E +L    +
Sbjct: 261  GLQVGSHRVRMSRGFEANAPAFDRHFRTLKNLYGKQIIV-NLLGSKE---GEHML----S 312

Query: 1442 KAIHYINKGLPDDERLKFLHMDLSKLSRRKGTNVLGLLNKVASDVLELTD--LLHCEITT 1615
            KA     K       ++ ++ D  ++   KG     L + +   V +  D  + H +   
Sbjct: 313  KAFQSHLKASEHAADIQMVNFDYHQMV--KGGKAEKLHSVLKPQVQKFLDYGIFHFD--- 367

Query: 1616 SSKPLDASSGQGSSDIKRNDDFCAATMVPLLLQKGVLRTNCIDCLDRTNVAQFAYGLAAL 1795
                         S+++R              Q G +RTNC+DCLDRTN  Q   GL  L
Sbjct: 368  ------------GSEVQR-------------CQSGTVRTNCLDCLDRTNSVQAFLGLEML 402

Query: 1796 GRQLHVLKLTEEPKIDLHDPLADDLMDFYERMGDTLAIQYGGSAAHNKIFCEQRGQWKAA 1975
             +QL  L L E+P+  L     +     +   GD+++  Y G+ A         G+ K  
Sbjct: 403  TKQLEALGLAEKPQ--LVTRFQEVFRSMWSVNGDSISKIYAGTGA-------LEGKAKLK 453

Query: 1976 TQSQEFLRTLQRYYNNAYTDPEKQDAINVFL 2068
              ++   RT+Q    N + D  KQ+AI+V L
Sbjct: 454  DGARSVSRTIQ----NNFFDSSKQEAIDVLL 480

>Q12271:INP53_YEAST Inositol-1,4,5-trisphosphate 5-phosphatase 3 - Saccharomyces|
            cerevisiae (Baker's yeast)
          Length = 1107

 Score =  132 bits (333), Expect = 7e-30
 Identities = 135/526 (25%), Positives = 223/526 (42%), Gaps = 32/526 (6%)
 Frame = +2

Query: 608  GLKFVT--KCYGIIGFMKFLGPYYMVVITRRRKVGTIC---------GHDIYSIGKSEMI 754
            G K +T  + +G+IG ++  G  ++  IT + KV   C           D + +  +   
Sbjct: 51   GFKRLTSHEIFGVIGLIEVNGLLFVGAITGKSKVAQPCPGETVNKIFAVDFFCLNDNSWD 110

Query: 755  AIPCPI----VCPNVANSRDENRYKRLLCSVDLTK-----DFFFSYSYNIMRSLQ-KNIN 904
             I        V P  A++  ++   +  C  +L K      F++S  +++  +LQ +   
Sbjct: 111  FIEIDSSGYPVLPETASTEYQDALPKHPC-YELKKLLSNGSFYYSSDFDLTSTLQHRGYG 169

Query: 905  DKNTGHVVYETMFVWNEFLTRAM---RNHLKNT--------DWTVALVHGFFKQSKLAVS 1051
              +     YE  ++WN FL + M   R+HL            +   ++ GF +     V 
Sbjct: 170  QHSLSTDTYEEEYMWNSFLMQEMITYRDHLDTNLKQILDDEGFLTTVIRGFAETFVSYVK 229

Query: 1052 GKDFWLTLIARRSRHFAGTRFMKRGVNEKGRVANDVETEQIVFEDTPDDIPSQITSVVQH 1231
                 LT+I+++S   AGTRF  RGV+++  VAN VETE I++            +  Q 
Sbjct: 230  KLKVALTIISKQSWKRAGTRFNARGVDDEANVANFVETEFIMYSS------QYCYAFTQI 283

Query: 1232 RGSIPLVWFQETSRLNIRPEITLKSDVDYKATRLHFENLVLRYGNPIVILNLIKTREKKP 1411
            RGSIP+ W Q TS +N R +IT   +        H    V +YG P+ ++NL+ T   K 
Sbjct: 284  RGSIPVFWEQGTSLINPRVQITRSFEATQPVFDKHIMKSVEKYG-PVHVVNLLST---KS 339

Query: 1412 RESLLRAEFAKAIHYINKGLPDDERLKFLHMDLSKLSRRKGTNVLGLLNKVASDVLELTD 1591
             E  L   + + + + +K L  ++ +     D  K + ++G + +  L  +  D L    
Sbjct: 340  SEIELSKRYKEHLTH-SKKLNFNKDIFLTEFDFHKETSQEGFSGVRKLIPLILDSL---- 394

Query: 1592 LLHCEITTSSKPLDASSGQGSSDIKRNDDFCAATMVPLLLQKGVLRTNCIDCLDRTNVAQ 1771
                           SSG  S D++   +           Q G+ RTNC+DCLDRTN+AQ
Sbjct: 395  --------------LSSGYYSYDVREKKNISE--------QHGIFRTNCLDCLDRTNLAQ 432

Query: 1772 FAYGLAALGRQLHVLKLTEEPKIDLHDPLADDLMDFYERMGDTLAIQYGGSAAHNKIFCE 1951
                LAA    L   +L         D         +   GD ++  Y G+ A    F  
Sbjct: 433  QIISLAAFRTFLEDFRLISSNSFIDDDDFVSKHNTLWADHGDQISQIYTGTNALKSSF-S 491

Query: 1952 QRGQWKAATQSQEFLRTLQRYYNNAYTDPEKQDAINVFLGHFQPQQ 2089
            ++G+   A    +  +++ R Y N + D EKQ  I+  LG    Q+
Sbjct: 492  RKGKMSLAGALSDATKSVSRIYINNFMDKEKQQNIDTLLGRLPYQK 537

>O43426:SYNJ1_HUMAN Synaptojanin-1 - Homo sapiens (Human)|
          Length = 1575

 Score =  130 bits (328), Expect = 3e-29
 Identities = 136/509 (26%), Positives = 226/509 (44%), Gaps = 15/509 (2%)
 Frame = +2

Query: 587  EGNRLTGGLKFVTKCYGIIGFMKF-LGP---YYMVVITRRRKVGTICGHDIYSIGKSEMI 754
            E   + G    V   YG++G ++  LG    +Y+V++T    VG I   +++ +  +E I
Sbjct: 45   EKEAIKGTYSKVLDAYGLLGVLRLNLGDTMLHYLVLVTGCMSVGKIQESEVFRVTSTEFI 104

Query: 755  AIPCPIVCPNVANSRDENRYKRLLCSVDLTKDFFFSYS---------YNIMRSLQKNIND 907
            ++          +S DE+R   +   ++ + +F+F++S          N  RS+Q+   D
Sbjct: 105  SLRI--------DSSDEDRISEVRKVLN-SGNFYFAWSASGISLDLSLNAHRSMQEQTTD 155

Query: 908  KNTGHVVYETMFVWNEFLTRAMRNHLKNTD-WTVALVHGFFKQSKLAVSGKDFWLTLIAR 1084
                       F WN+ L   ++++  N D W + L+ G  +   +  + K     LI+R
Sbjct: 156  NR---------FFWNQSLHLHLKHYGVNCDDWLLRLMCGGVEIRTIYAAHKQAKACLISR 206

Query: 1085 RSRHFAGTRFMKRGVNEKGRVANDVETEQIVFEDTPDDIPSQITSVVQHRGSIPLVWFQE 1264
             S   AGTRF  RG N+ G VAN VETEQ+V+ D        ++S +Q RGS+PL W Q 
Sbjct: 207  LSCERAGTRFNVRGTNDDGHVANFVETEQVVYLD------DSVSSFIQIRGSVPLFWEQP 260

Query: 1265 TSRL-NIRPEITLKSDVDYKATRLHFENLVLRYGNPIVILNLIKTREKKPRESLLRAEFA 1441
              ++ + R  ++   + +  A   HF  L   YG  I++ NL+ ++E    E +L    +
Sbjct: 261  GLQVGSHRVRMSRGFEANAPAFDRHFRTLKNLYGRQIIV-NLLGSKE---GEHML----S 312

Query: 1442 KAIHYINKGLPDDERLKFLHMDLSKLSRRKGTNVLGLLNKVASDVLELTDLLHCEITTSS 1621
            KA     K       ++ ++ D  ++   KG     L + +   V +  D          
Sbjct: 313  KAFQSHLKASEHAADIQMVNFDYHQMV--KGGKAEKLHSVLKPQVQKFLDYGFFYF---- 366

Query: 1622 KPLDASSGQGSSDIKRNDDFCAATMVPLLLQKGVLRTNCIDCLDRTNVAQFAYGLAALGR 1801
                       S+++R              Q G +RTNC+DCLDRTN  Q   GL  L +
Sbjct: 367  ---------NGSEVQR-------------CQSGTVRTNCLDCLDRTNSVQAFLGLEMLAK 404

Query: 1802 QLHVLKLTEEPKIDLHDPLADDLMDFYERMGDTLAIQYGGSAAHNKIFCEQRGQWKAATQ 1981
            QL  L L E+P+  L     +     +   GD+++  Y G+ A         G+ K    
Sbjct: 405  QLEALGLAEKPQ--LVTRFQEVFRSMWSVNGDSISKIYAGTGA-------LEGKAKLKDG 455

Query: 1982 SQEFLRTLQRYYNNAYTDPEKQDAINVFL 2068
            ++   RT+Q    N + D  KQ+AI+V L
Sbjct: 456  ARSVTRTIQ----NNFFDSSKQEAIDVLL 480

>O14127:YF51_SCHPO Uncharacterized protein C3C7.01c - Schizosaccharomyces pombe (Fission|
            yeast)
          Length = 611

 Score =  130 bits (326), Expect = 5e-29
 Identities = 134/495 (27%), Positives = 221/495 (44%), Gaps = 13/495 (2%)
 Frame = +2

Query: 638  IIGFMKFLGPYYMVVITRRRKVGTICGHDIYSIGKSEMIAIPCPI-VCPNVANSRDENRY 814
            + GF++     Y+V++T       I G++IY   K  +  I   +     + N +DE   
Sbjct: 51   LYGFIRLKIYKYVVLVTSCDLHAAILGNNIYRARKFAIFPITRTLPFSTGLLNIKDEEEL 110

Query: 815  KRL-LCSVDLTK-DFFFSYSYNIMRSLQKNINDKNTGHVV--YETMFVWNEF----LTRA 970
              + L +  L+K    FS + ++  SLQ+      +  +   Y   F WN++    L   
Sbjct: 111  HYISLLNKHLSKGQILFSPTLDLTCSLQRLRVLTQSFELTSKYNYRFFWNKYAFHELIEL 170

Query: 971  MRNHLKNTDWTVALVHGFFKQSKLAVSGKDFWLTLIARRSRHFAGTRFMKRGVNEKGRVA 1150
                L   +W   ++ G    +   +   +  L +I R S  +AGTR+  RGVN +G  A
Sbjct: 171  TNKDLGFQEWIQPMIQGNIAITNSFLKTYNLRLCVITRHSPDYAGTRYFTRGVNAQGSAA 230

Query: 1151 NDVETEQIVFEDTPDDIPSQ-ITSVVQHRGSIPLVWFQETSRLNIRPEITLKSDVDYKAT 1327
            N  E EQI+  ++P  +  Q + S  Q RGSIP+ W  E + L+ RP ++L+  +DY  T
Sbjct: 231  NFNEIEQIIMIESPITLEEQMVLSFTQIRGSIPMFW-AEVNDLHYRPLLSLQ-PLDYSET 288

Query: 1328 RL--HFENLVLRYGNPIVILNLIKTREKKPRESLLRAEFAKAIHYINKGLPDDERLKFLH 1501
                HF+ L   YG+ +V++NL+   ++K RE+ LR+ F K     NK  P    L +++
Sbjct: 289  VFGKHFQELANDYGDNLVVVNLL---DQKGREAPLRSGFEKLCKR-NKNPP----LSYVY 340

Query: 1502 MDLSKLSRRKGTNVLGLLNKVASDVLELTDLLHCEITTSSKPLDASSGQGSSDIKRNDDF 1681
             D  K   R   N+   L ++ S ++E                 A  G  ++        
Sbjct: 341  YDYHKQGSR---NLPLFLAEIQSLLIE-------------GKYYAEHGSKTT-------- 376

Query: 1682 CAATMVPLLLQKGVLRTNCIDCLDRTNVAQFAYGLAALGRQLH-VLKLTEEPKIDLHDPL 1858
                     +Q   +RTNC+DCLDRTNV Q +     L  QLH +  L+    ++ +D  
Sbjct: 377  --------AMQTNFVRTNCMDCLDRTNVIQTSIAQFILNMQLHDIGVLSSSESLEEYDSF 428

Query: 1859 ADDLMDFYERMGDTLAIQYGGSAAHNKIFCEQRGQWKAATQSQEFLRTLQRYYNNAYTDP 2038
              D    +   GD ++  Y G+ A  K    + G        ++ L   +RY  N + D 
Sbjct: 429  LQDFRLIWANTGDYISDLYTGTPA-LKGDVTRHGTRTIFGAFKDLLNCFRRYILNNFFDG 487

Query: 2039 EKQDAINVFLGHFQP 2083
              QD+ ++ LG F+P
Sbjct: 488  MLQDSYDLGLGVFRP 502

>Q8CHC4:SYNJ1_MOUSE Synaptojanin-1 - Mus musculus (Mouse)|
          Length = 1574

 Score =  127 bits (320), Expect = 2e-28
 Identities = 133/502 (26%), Positives = 226/502 (45%), Gaps = 8/502 (1%)
 Frame = +2

Query: 587  EGNRLTGGLKFVTKCYGIIGFMKF-LGP---YYMVVITRRRKVGTICGHDIYSIGKSEMI 754
            E   + G    V   YG++G ++  LG    +Y+V++T    VG I   +++ +  +E I
Sbjct: 45   EKEAIKGTYAKVLDAYGLLGVLRLNLGDTMLHYLVLVTGCMSVGKIQESEVFRVTSTEFI 104

Query: 755  AIPCPIVCPNVANSRDENRYKRLLCSVDLTKDFFFSYSYN-IMRSLQKNINDKNTGHVVY 931
            ++          ++ DE+R   +   ++ + +F+F++S + +   L  N +     H   
Sbjct: 105  SLR--------VDASDEDRISEVRKVLN-SGNFYFAWSASGVSLDLSLNAHRSMQEHTT- 154

Query: 932  ETMFVWNEFLTRAMRNHLKNTD-WTVALVHGFFKQSKLAVSGKDFWLTLIARRSRHFAGT 1108
            +  F WN+ L   ++++  N D W + L+ G  +   +  + K     LI+R S   AGT
Sbjct: 155  DNRFFWNQSLHLHLKHYGVNCDDWLLRLMCGGVEIRTIYAAHKQAKACLISRLSCERAGT 214

Query: 1109 RFMKRGVNEKGRVANDVETEQIVFEDTPDDIPSQITSVVQHRGSIPLVWFQETSRLNI-R 1285
            RF  RG N+ G VAN VETEQ+++ D        ++S +Q RGS+PL W Q   ++   R
Sbjct: 215  RFNVRGTNDDGHVANFVETEQVIYLD------DCVSSFIQIRGSVPLFWEQPGLQVGSHR 268

Query: 1286 PEITLKSDVDYKATRLHFENLVLRYGNPIVILNLIKTREKKPRESLLRAEFAKAIHYINK 1465
              ++   + +  A   HF  L   YG  IV+ NL+ ++E +   S       KA  + + 
Sbjct: 269  VRMSRGFEANAPAFDRHFRTLKDLYGKQIVV-NLLGSKEGEHMLSKAFQSHLKASEHAS- 326

Query: 1466 GLPDDERLKFLHMDLSKLSRRKGTNVLGLLNKVASDVLELTDLLHCEITTSSKPLDASSG 1645
               D   + F +  + K  + +                +L  +L  ++    K LD    
Sbjct: 327  ---DIHMVSFDYHQMVKGGKAE----------------KLHSILKPQV---QKFLDYGFF 364

Query: 1646 Q-GSSDIKRNDDFCAATMVPLLLQKGVLRTNCIDCLDRTNVAQFAYGLAALGRQLHVLKL 1822
                S+++R              Q G +RTNC+DCLDRTN  Q   GL  L +QL  L L
Sbjct: 365  YFDGSEVQR-------------CQSGTVRTNCLDCLDRTNSVQAFLGLEMLAKQLEALGL 411

Query: 1823 TEEPKIDLHDPLADDLMDFYERMGDTLAIQYGGSAAHNKIFCEQRGQWKAATQSQEFLRT 2002
             E+P+  L     +     +   GD+++  Y G+ A         G+ K    ++   RT
Sbjct: 412  AEKPQ--LVTRFQEVFRSMWSVNGDSISKIYAGTGA-------LEGKAKLKDGARSVTRT 462

Query: 2003 LQRYYNNAYTDPEKQDAINVFL 2068
            +Q    N + D  KQ+AI+V L
Sbjct: 463  IQ----NNFFDSSKQEAIDVLL 480

>Q62910:SYNJ1_RAT Synaptojanin-1 - Rattus norvegicus (Rat)|
          Length = 1574

 Score =  127 bits (318), Expect = 4e-28
 Identities = 135/502 (26%), Positives = 219/502 (43%), Gaps = 8/502 (1%)
 Frame = +2

Query: 587  EGNRLTGGLKFVTKCYGIIGFMKF-LGP---YYMVVITRRRKVGTICGHDIYSIGKSEMI 754
            E   + G    V   YG++G ++  LG    +Y+V++T    VG I   +++ +  +E I
Sbjct: 45   EKEAIKGTYAKVLDAYGLLGVLRLNLGDTMLHYLVLVTGCMSVGKIQESEVFRVTSTEFI 104

Query: 755  AIPCPIVCPNVANSRDENRYKRLLCSVDLTKDFFFSYSYN-IMRSLQKNINDKNTGHVVY 931
            ++          ++ DE+R   +   ++ + +F+F++S + +   L  N +     H   
Sbjct: 105  SLR--------VDASDEDRISEVRKVLN-SGNFYFAWSASGVSLDLSLNAHRSMQEHTT- 154

Query: 932  ETMFVWNEFLTRAMRNHLKNTD-WTVALVHGFFKQSKLAVSGKDFWLTLIARRSRHFAGT 1108
            +  F WN+ L   ++++  N D W + L+ G  +   +  + K     LI+R S   AGT
Sbjct: 155  DNRFFWNQSLHLHLKHYGVNCDDWLLRLMCGGVEIRTIYAAHKQAKACLISRLSCERAGT 214

Query: 1109 RFMKRGVNEKGRVANDVETEQIVFEDTPDDIPSQITSVVQHRGSIPLVWFQETSRLNI-R 1285
            RF  RG N+ G VAN VETEQ+++ D        ++S +Q RGS+PL W Q   ++   R
Sbjct: 215  RFNVRGTNDDGHVANFVETEQVIYLD------DCVSSFIQIRGSVPLFWEQPGLQVGSHR 268

Query: 1286 PEITLKSDVDYKATRLHFENLVLRYGNPIVILNLIKTREKKPRESLLRAEFAKAIHYINK 1465
              ++   + +  A   HF  L   YG  IV+ NL+ ++E    E +L   F         
Sbjct: 269  VRMSRGFEANAPAFDRHFRTLKDLYGKQIVV-NLLGSKEG---EHMLSKAF-------QS 317

Query: 1466 GLPDDERLKFLHM-DLSKLSRRKGTNVLGLLNKVASDVLELTDLLHCEITTSSKPLDASS 1642
             L   E    +HM         KG     L + +   V +  D             D S+
Sbjct: 318  HLKASEHASDIHMVSFDYHQMVKGGKAEKLHSVLKPQVQKFLDY-------GFFYFDGSA 370

Query: 1643 GQGSSDIKRNDDFCAATMVPLLLQKGVLRTNCIDCLDRTNVAQFAYGLAALGRQLHVLKL 1822
             Q                     Q G +RTNC+DCLDRTN  Q   GL  L +QL  L L
Sbjct: 371  VQRC-------------------QSGTVRTNCLDCLDRTNSVQAFLGLEMLAKQLEALGL 411

Query: 1823 TEEPKIDLHDPLADDLMDFYERMGDTLAIQYGGSAAHNKIFCEQRGQWKAATQSQEFLRT 2002
             E+P+  L     +     +   GD+++  Y G+ A         G+ K    ++   RT
Sbjct: 412  AEKPQ--LVTRFQEVFRSMWSVNGDSISKIYAGTGA-------LEGKAKLKDGARSVTRT 462

Query: 2003 LQRYYNNAYTDPEKQDAINVFL 2068
            +Q    N + D  KQ+AI+V L
Sbjct: 463  IQ----NNFFDSSKQEAIDVLL 480

>O43001:SYJ1_SCHPO Synaptojanin homolog 1 - Schizosaccharomyces pombe (Fission yeast)|
          Length = 1076

 Score =  119 bits (299), Expect = 6e-26
 Identities = 129/526 (24%), Positives = 210/526 (39%), Gaps = 39/526 (7%)
 Frame = +2

Query: 626  KCYGIIGFMKFLGPYYMVVITRRRKVGTICGHD---------IYSIGKSEMIAIPCPIVC 778
            + YG +G ++  G  ++ VI+   +V  +   +          YS+ +S    I      
Sbjct: 58   RIYGTLGLIELEGSNFLCVISGASEVARVRDKERVFRIMEVCFYSVNRSNWDHIRQENYS 117

Query: 779  PNVANSRDENR-----YKRL------LCSVDLTKDFFFSYSYNIMRSLQKNINDKNTG-- 919
            P++ +  D +      YK        L  +     F+FS  ++I   LQ   +   T   
Sbjct: 118  PDIPDGYDTDTQGYDSYKYAAEPFSSLRKLLTNGSFYFSLDFDITTRLQLRTSQTMTEPQ 177

Query: 920  HVVYETMFVWNEFLTRAM---RNHLKNTD--------WTVALVHGFFKQSKLAVSGKDFW 1066
            +    T F+WNEF+ R +   R+HL   +        +    + GF    +  +  +   
Sbjct: 178  YDSMHTQFMWNEFMLRQLIKFRSHLNGDEKSALDGCRFFTCAIRGFASTEQFKLGIQTIR 237

Query: 1067 LTLIARRSRHFAGTRFMKRGVNEKGRVANDVETEQIVFEDTPDDIPSQITSVVQHRGSIP 1246
            L+LI+R S   AGTRF+ RGV++ G VAN VETE I+      D      S  Q RGSIP
Sbjct: 238  LSLISRLSSLRAGTRFLSRGVDDDGNVANFVETETIL------DSSKYCVSYCQVRGSIP 291

Query: 1247 LVWFQE-TSRLNIRPEITLKSDVDYKATRLHFENLVLRYGNPIVILNLIKTRE-KKPRES 1420
            + W QE       + +IT   +    A   HF +L+  YG P+ I+NL+ T   ++    
Sbjct: 292  IFWEQEGVQMFGQKIDITRSLEATRAAFEKHFTSLIEEYG-PVHIINLLGTGSGERSLSE 350

Query: 1421 LLRAEFAKAIHYINKGLPDDERLKFLHMDLSKLSRRKGTNVLGLLNKVASDVLELTDLLH 1600
             LR     +        P+ + +     D     R               D  ++  +++
Sbjct: 351  RLRQHIQLS--------PEKDLIHLTEFDYHSQIRS------------FEDANKIRPMIY 390

Query: 1601 CEITTSSKPLDASSGQGSSDIKRNDDFCAATMVPLLLQKGVLRTNCIDCLDRTNVAQFAY 1780
             +  T     + + GQ                  +++Q GV RTNC+DCLDRTNV Q   
Sbjct: 391  SDAETFGFYFENNEGQS-----------------IVVQDGVFRTNCLDCLDRTNVIQNLV 433

Query: 1781 GLAALGRQLHVLKLTEEPKIDLHDPLADDLMDFYERM----GDTLAIQYGGSAAHNKIFC 1948
                L          E+  I        D    +  +    GD LA  Y G+ A    F 
Sbjct: 434  SRVFL----------EQVMIYTRQNAGYDFWQVHSTIWANNGDALARIYTGTGALKSSF- 482

Query: 1949 EQRGQWKAATQSQEFLRTLQRYYNNAYTDPEKQDAINVFLGHFQPQ 2086
             ++G+   A    +  +++ R Y N + D  +Q+ I++ LG    Q
Sbjct: 483  TRKGKLSIAGALNDLSKSVGRMYINNFQDKGRQETIDLLLGRLIDQ 528

>P50942:YNK6_YEAST Uncharacterized protein YNL106C - Saccharomyces cerevisiae (Baker's|
            yeast)
          Length = 1183

 Score =  115 bits (289), Expect = 9e-25
 Identities = 107/427 (25%), Positives = 183/427 (42%), Gaps = 14/427 (3%)
 Frame = +2

Query: 851  FFFSYSYNIMRSLQKN-INDKNTGHVVYETMFVWNEFLTRAMRNHLKNTDWTV------- 1006
            F++S  +++  +LQK    + +     ++  F+WN FL   +  +    D T        
Sbjct: 176  FYYSTDFDLTCTLQKRGFTEHSLSFDDFDREFMWNSFLMDEIITYRDRLDVTAKELLDQR 235

Query: 1007 ----ALVHGFFKQSKLAVSGKDFWLTLIARRSRHFAGTRFMKRGVNEKGRVANDVETEQI 1174
                 ++ GF +     ++     LT+I+R+S   AGTRF  RG+++ G VAN VETE I
Sbjct: 236  GFLTTVIRGFAETIFSYINRLKVGLTIISRQSWKRAGTRFNARGIDDDGHVANFVETEMI 295

Query: 1175 VFEDTPDDIPSQITSVVQHRGSIPLVWFQETSRLNIRPEITLKSDVDYKATRLHFENLVL 1354
            ++            +  Q RGS+P+ W Q+TS ++ + +IT   +        HF  L  
Sbjct: 296  MYSS------QYCYAFTQIRGSLPIFWEQDTSLISPKIQITRSVEATQPTFDEHFIRLFK 349

Query: 1355 RYGNPIVILNLIKTREKKPRESLLRAEFAKAIHYINKGLPDDERLKFL-HMDLSKLSRRK 1531
            +YG P+ I+NL+ T+  + + S    E  K    +  G     R  FL   D  + + + 
Sbjct: 350  KYG-PVHIINLLSTKSSEIQLSRRYKEQLKNSEKMKIG-----RDVFLTSFDFHRETSQD 403

Query: 1532 GTNVLG-LLNKVASDVLELTDLLHCEITTSSKPLDASSGQGSSDIKRNDDFCAATMVPLL 1708
            G      ++ K+ + +L+                   +G  S D+K            + 
Sbjct: 404  GFAAASRIIPKIRNTILD-------------------AGYFSYDVKEGR--------LIS 436

Query: 1709 LQKGVLRTNCIDCLDRTNVAQFAYGLAALGRQLHVLKLTEEPKIDLHDPLADDLMDFYER 1888
             Q GV RTNC+DCLDRTN+ Q    LA     L   +L +       +     +   +  
Sbjct: 437  EQDGVFRTNCLDCLDRTNLIQQTISLAVFKLFLEDFRLVKPSSFIDDNEFVQKVNALWAD 496

Query: 1889 MGDTLAIQYGGSAAHNKIFCEQRGQWKAATQSQEFLRTLQRYYNNAYTDPEKQDAINVFL 2068
             GD ++  Y G+ A    +  ++G+   +    +  +++ R Y N + D  KQ  I+  L
Sbjct: 497  NGDQISQIYTGTNALKSSY-SRKGKMSFSGALSDATKSVSRMYINNFVDKGKQQNIDTLL 555

Query: 2069 GHFQPQQ 2089
            G    QQ
Sbjct: 556  GKLPHQQ 562

>Q9D2G5:SYNJ2_MOUSE Synaptojanin-2 - Mus musculus (Mouse)|
          Length = 1434

 Score =  108 bits (271), Expect = 1e-22
 Identities = 129/499 (25%), Positives = 211/499 (42%), Gaps = 16/499 (3%)
 Frame = +2

Query: 620  VTKCYGIIGFMKFLGP----YYMVVITRRRKVGTICGHDIYSIGKSEMIAIPCPIVCPNV 787
            +T  YG +G ++         ++V++T    VG I   +IY I  +E+         P  
Sbjct: 57   LTDAYGCLGELRLQSGGVPLSFLVLVTGCMSVGRIPDAEIYKITATELY--------PLQ 108

Query: 788  ANSRDENRY---KRLLCSVDLTKDFFFSYS-----YNIMRSLQKNINDKNTGHVVYETMF 943
              +++E+R    K++L S      F+F++      +++    QK  +D +     + T F
Sbjct: 109  EEAKEEDRLPTLKKILSS----GVFYFAWPNDGACFDLTIRAQKQGDDGSE----WGTSF 160

Query: 944  VWNEFLTRAMRNHLKNT-DWTVALVHGFFKQSKLAVSGKDFWLTLIARRSRHFAGTRFMK 1120
             WN+ L   +R H  N  +W + ++ G      +  S K     LI+R S   AG RF+ 
Sbjct: 161  FWNQLLHVPLRQHQVNCHNWLLKVICGVVTIRTVYASHKQAKACLISRISCERAGARFLT 220

Query: 1121 RGVNEKGRVANDVETEQIVFEDTPDDIPSQITSVVQHRGSIPLVWFQ---ETSRLNIRPE 1291
            RGVN+ G V+N VETEQ ++ D        ++S VQ RGS+PL W Q   +    ++R  
Sbjct: 221  RGVNDDGHVSNFVETEQTIYMD------DGVSSFVQIRGSVPLFWEQPGLQVGSHHLRLH 274

Query: 1292 ITLKSDVDYKATRLHFENLVLRYGNPIVILNLIKTREKKPRESLLRAEFAKAIHYINKGL 1471
              L+++    A   H   L  +YG  +V+ NL+ +R     E +L   F K + + +   
Sbjct: 275  RGLEANA--PAFERHMVLLKEQYGKQVVV-NLLGSR---GGEEVLNRAFKKLL-WASCHA 327

Query: 1472 PDDERLKFLHMDLSKLSRRKGTNVLGLLNKVASDVLELTDLLHCEITTSSKPLDASSGQG 1651
             D   + F     +K                   + +L +LL  ++    +         
Sbjct: 328  GDTPMINFDFHQFAK----------------GRKLEKLENLLRPQLQLHWEDFGV----- 366

Query: 1652 SSDIKRNDDFCAATMVPLLLQKGVLRTNCIDCLDRTNVAQFAYGLAALGRQLHVLKLTEE 1831
                     F     V    QKG LR NC+DCLDRTN  Q    L  L  QL  L L  +
Sbjct: 367  ---------FAKGENVSPRFQKGTLRMNCLDCLDRTNTVQCFIALEVLHLQLESLGLNSK 417

Query: 1832 PKIDLHDPLADDLMDFYERMGDTLAIQYGGSAAHNKIFCEQRGQWKAATQSQEFLRTLQR 2011
            P I   D   +     +   G +L+  + GS A         G+ K   + ++  R++ R
Sbjct: 418  PII---DRFVESFKAMWSLNGHSLSKVFTGSRA-------LEGKAKVG-KLKDGARSMSR 466

Query: 2012 YYNNAYTDPEKQDAINVFL 2068
               + + D  KQ+AI + L
Sbjct: 467  TIQSNFFDGVKQEAIKLLL 485

>O15056:SYNJ2_HUMAN Synaptojanin-2 - Homo sapiens (Human)|
          Length = 1496

 Score =  108 bits (270), Expect = 1e-22
 Identities = 130/499 (26%), Positives = 212/499 (42%), Gaps = 16/499 (3%)
 Frame = +2

Query: 620  VTKCYGIIGFMKFLGP----YYMVVITRRRKVGTICGHDIYSIGKSEMIAIPCPIVCPNV 787
            +T  YG +G ++         ++V++T    VG I   +IY I  ++          P  
Sbjct: 57   LTDAYGCLGELRLKSGGTSLSFLVLVTGCTSVGRIPDAEIYKITATDFY--------PLQ 108

Query: 788  ANSRDENRY---KRLLCSVDLTKDFFFSYS-----YNIMRSLQKNINDKNTGHVVYETMF 943
              +++E R    K++L S      F+FS+      +++    QK  +D +     +   F
Sbjct: 109  EEAKEEERLIALKKILSS----GVFYFSWPNDGSRFDLTVRTQKQGDDSSE----WGNSF 160

Query: 944  VWNEFLTRAMRNH-LKNTDWTVALVHGFFKQSKLAVSGKDFWLTLIARRSRHFAGTRFMK 1120
             WN+ L   +R H +   DW + ++ G      +  S K     L++R S    GTRF  
Sbjct: 161  FWNQLLHVPLRQHQVSCCDWLLKIICGVVTIRTVYASHKQAKACLVSRVSCERTGTRFHT 220

Query: 1121 RGVNEKGRVANDVETEQIVFEDTPDDIPSQITSVVQHRGSIPLVWFQ---ETSRLNIRPE 1291
            RGVN+ G V+N VETEQ+++ D        ++S VQ RGS+PL W Q   +    ++R  
Sbjct: 221  RGVNDDGHVSNFVETEQMIYMD------DGVSSFVQIRGSVPLFWEQPGLQVGSHHLRLH 274

Query: 1292 ITLKSDVDYKATRLHFENLVLRYGNPIVILNLIKTREKKPRESLLRAEFAKAIHYINKGL 1471
              L+++    A   H   L  +YG  +V+ NL+ +R     E +L   F K + + +   
Sbjct: 275  RGLEANA--PAFDRHMVLLKEQYGQQVVV-NLLGSR---GGEEVLNRAFKKLL-WASCHA 327

Query: 1472 PDDERLKFLHMDLSKLSRRKGTNVLGLLNKVASDVLELTDLLHCEITTSSKPLDASSGQG 1651
             D   + F   D  + ++       G L K       L  LL  ++    +  D      
Sbjct: 328  GDTPMINF---DFHQFAKG------GKLEK-------LETLLRPQLKLHWEDFDV----- 366

Query: 1652 SSDIKRNDDFCAATMVPLLLQKGVLRTNCIDCLDRTNVAQFAYGLAALGRQLHVLKLTEE 1831
                     F     V    QKG LR NC+DCLDRTN  Q    L  L  QL  L L+ +
Sbjct: 367  ---------FTKGENVSPRFQKGTLRMNCLDCLDRTNTVQSFIALEVLHLQLKTLGLSSK 417

Query: 1832 PKIDLHDPLADDLMDFYERMGDTLAIQYGGSAAHNKIFCEQRGQWKAATQSQEFLRTLQR 2011
            P +   D   +     +   G +L+  + GS A         G+ K   + ++  R++ R
Sbjct: 418  PIV---DRFVESFKAMWSLNGHSLSKVFTGSRA-------LEGKAKVG-KLKDGARSMSR 466

Query: 2012 YYNNAYTDPEKQDAINVFL 2068
               + + D  KQ+AI + L
Sbjct: 467  TIQSNFFDGVKQEAIKLLL 485

>O55207:SYNJ2_RAT Synaptojanin-2 - Rattus norvegicus (Rat)|
          Length = 1496

 Score =  105 bits (263), Expect = 9e-22
 Identities = 131/499 (26%), Positives = 205/499 (41%), Gaps = 17/499 (3%)
 Frame = +2

Query: 623  TKCYGIIGFMKFLGP----YYMVVITRRRKVGTICGHDIYSIGKSEMIAIPCPIVCPNVA 790
            T  YG +G +          ++V++T    VG I   +IY I  +E          P   
Sbjct: 58   TDAYGCLGELSLKSGGVPLSFLVLVTGCTSVGRIPDAEIYKITGTEFY--------PLQE 109

Query: 791  NSRDENRY---KRLLCSVDLTKDFFFSYS-----YNIMRSLQKNINDKNTGHVVYETMFV 946
             +++E+R    K++L S      F+F++      +++    QK  +D +     + T F 
Sbjct: 110  EAKEEDRLPALKKILSS----GVFYFAWPNDGACFDLTIRAQKQGDDCSE----WGTSFF 161

Query: 947  WNEFLTRAMRNHLKNT-DWTVALVHGFFKQSKLAVSGKDFWLTLIARRSRHFAGTRFMKR 1123
            WN+ L   +R H  N  DW + ++ G      +  S K     LI+R S   AG RF+ R
Sbjct: 162  WNQLLHVPLRQHQVNCHDWLLKVICGVVTIRTVYASHKQAKACLISRISCERAGARFLTR 221

Query: 1124 GVNEKGRVANDVETEQIVFEDTPDDIPSQITSVVQHRGSIPLVWFQ---ETSRLNIRPEI 1294
            GVN+ G V+N VETEQ ++ D        ++S VQ RGS+PL W Q   +    ++R   
Sbjct: 222  GVNDDGHVSNFVETEQAIYMD------DGVSSFVQIRGSVPLFWEQPGLQVGSHHLRLHR 275

Query: 1295 TLKSDVDYKATRLHFENLVLRYGNPIVILNLIKTREKKPRESLLRAEFAKAIHYINKGLP 1474
             L+++    A   H   L  +YG  +V+ NL+ +R     E +L   F K + + +    
Sbjct: 276  GLEANA--PAFERHMVLLKEQYGQQVVV-NLLGSR---GGEEVLNRAFKKLL-WASCHAG 328

Query: 1475 DDERLKF-LHMDLSKLSRRKGTNVLGLLNKVASDVLELTDLLHCEITTSSKPLDASSGQG 1651
            D   + F  H         K  N+L    K+  D   +                      
Sbjct: 329  DTPMINFDFHQFAKGRKLEKLENLLRPQLKLHWDDFGV---------------------- 366

Query: 1652 SSDIKRNDDFCAATMVPLLLQKGVLRTNCIDCLDRTNVAQFAYGLAALGRQLHVLKLTEE 1831
                     F     V    QKG LR NC+DCLDRTN  Q    L  L  QL  L L  +
Sbjct: 367  ---------FAKGENVSPRFQKGTLRMNCLDCLDRTNTVQCFIALEVLHLQLESLGLNSK 417

Query: 1832 PKIDLHDPLADDLMDFYERMGDTLAIQYGGSAAHNKIFCEQRGQWKAATQSQEFLRTLQR 2011
            P   + D   +     +   G  L+  + GS A         G+ K   + ++  R++ R
Sbjct: 418  P---ITDRFVESFKAMWSLNGHGLSKVFTGSRA-------LEGKAKVG-KLKDGARSMSR 466

Query: 2012 YYNNAYTDPEKQDAINVFL 2068
               + + D  KQ+AI + L
Sbjct: 467  TIQSNFFDGVKQEAIKLLL 485

>P40559:YIA2_YEAST Uncharacterized protein YIL002C - Saccharomyces cerevisiae (Baker's|
            yeast)
          Length = 946

 Score = 60.5 bits (145), Expect = 4e-08
 Identities = 104/452 (23%), Positives = 171/452 (37%), Gaps = 44/452 (9%)
 Frame = +2

Query: 635  GIIGFMKFLGPYYMVVITRRRKVG------------------TICGHDIYSIGKSEMIAI 760
            G++G +   G  Y+ VI+  + VG                   +   D YS+       +
Sbjct: 71   GLLGLVCLNGDIYVAVISGVQNVGFPRWKLIDHQVRPSESIYKVLDVDFYSLENDVFDYL 130

Query: 761  PCPIVCPNVANSRDENRYKRLL----CSV--DLTKD--FFFSYSYNIMRSLQKNINDKNT 916
             C          R E  Y +L+    C     L  D  F++S  ++I   ++ +    N 
Sbjct: 131  LC---------ERSEQNYDKLIHEHPCGPLKKLFSDGTFYYSRDFDISNIVKNHGLSHNL 181

Query: 917  GHVV--YETMFVWNEFLTRAMRNH-----------LKNTDWTVALVHGFFKQSKLAVSGK 1057
             + V   +  F+WN  L   + N              N  +   ++ G+ K + +     
Sbjct: 182  EYTVDNQDLSFIWNANLASEVINWRSKISNEEKQLFANAGFLTFVIRGYCKTALIEDGPN 241

Query: 1058 DFWLTLIARRSRHFAGTRFMKRGVNEKGRVANDVETEQIVFEDTPDDIPSQITSVVQHRG 1237
               +T+I+R S           G++E GRV+  VETE +V  +        I S  Q  G
Sbjct: 242  TASITIISRISTESKQDTLELEGISEDGRVSLFVETEIVVTTE------KFIFSYTQVNG 295

Query: 1238 SIPLVWFQETSRL--NIRPEITLKSDVDYKATRLHFENLVLRYGNPIVILNLIKTREKKP 1411
            SIPL W    S+L    + ++T  S     A   HF+NL  +YG  + I+N+IK + +  
Sbjct: 296  SIPLFWESVESQLLYGKKIKVTKDSIEAQGAFDRHFDNLTSKYG-VVSIVNIIKPKSES- 353

Query: 1412 RESLLRAEFAKAIHYINKGLPDDERLKFLHMDLSKLSRRKGTNVLGLLNKVASDVLELTD 1591
            +E L       A+ Y  K   + + +K  +++ S     K  + L  L K   D+ E   
Sbjct: 354  QEKL-------ALTY--KDCAESKGIKITNIEYSSSVLTKSPHKLLYLLK--QDIYEF-- 400

Query: 1592 LLHCEITTSSKPLDASSGQGSSDIKRNDDFCAATMVPLLLQKGVLRTNCIDCLDRTNVAQ 1771
                             G  + DI R   F          Q GVLR +  D +++ N  +
Sbjct: 401  -----------------GAFAYDISRGIYFAK--------QTGVLRISAFDSIEKPNTVE 435

Query: 1772 FAYG---LAALGRQLHVLKLTEEPKIDLHDPL 1858
                   L     ++ V +LT  P +D HD L
Sbjct: 436  RLVSKEVLELTTNEIDVFELT-SPFLDAHDKL 466

>Q8K9N3:ODO1_BUCAP 2-oxoglutarate dehydrogenase E1 component - Buchnera aphidicola|
            subsp. Schizaphis graminum
          Length = 923

 Score = 36.6 bits (83), Expect = 0.68
 Identities = 54/220 (24%), Positives = 83/220 (37%), Gaps = 33/220 (15%)
 Frame = +2

Query: 848  DFFFSYSYNI-MRSLQKNINDKNTGHVVYETMFVWNEFLTRAMRNHLKNTDWTVALVHGF 1024
            DF  S  Y I +R L + +N+K  G + +E M++ N F             W    +  F
Sbjct: 133  DFKNSSQYEIKIRDLYEQLNNKYCGSIGFEYMYIENSF----------EKKWITKHIELF 182

Query: 1025 FKQSKLAVSGKDFWL--TLIARRSRHFAGTRF--MKRGVNEKGRVANDVETEQIVFEDTP 1192
            FK++      K  +L   L       + G +F   KR   E G     +  E I +    
Sbjct: 183  FKENLFIKKEKIRFLKEILYGETFEKYLGKKFSGTKRFSLEGGETLISILHEIIRYSKKN 242

Query: 1193 DDIPSQITSVVQHRGSI----------PLVWFQETSRLNIRPEIT------------LKS 1306
            D   S+I   + HRG +          P V F E S +NI  E +            +K+
Sbjct: 243  D--VSEIILGMAHRGRLNVLVNVLNKNPQVLFNEFSGINIPKEYSGDVKYHMGGITKIKN 300

Query: 1307 DVDYKATRLHFENLVLRYGNPIVI------LNLIKTREKK 1408
            D      +L +    L   NP+V+      +N +K  E K
Sbjct: 301  DKKKIYLKLAYNPSHLEIVNPVVLGIARASINQLKISENK 340

>P15617:YM16_PARTE Uncharacterized mitochondrial protein ORF16 - Paramecium tetraurelia|
          Length = 189

 Score = 35.0 bits (79), Expect = 2.0
 Identities = 34/129 (26%), Positives = 53/129 (41%)
 Frame = -2

Query: 3166 YLYHIYLQEKSLFFVIFHVFFCILFLKVNKNISCLPKLTLEKESDRYISFAYHSLPFPSL 2987
            ++ H    + S FF++F +FF  L      NI    +   E    RYISF       P+L
Sbjct: 54   FVLHEIFSKASYFFLVFELFFSNLMDAFLNNIVVFFEFD-EPTLRRYISFMD-----PTL 107

Query: 2986 RSILHHSTPTLSEQNQTTSHHHLHSFLN*VTALEL*STERIVPILLLLLQPWRMAALCGC 2807
             SI H     + +   TT+H    +      A+ L  +  I P+  +L   + +  +   
Sbjct: 108  FSIYHPEAVFIQKSLLTTNHLSYFANFKLNVAVLLDKSNAIEPLNYMLQVSFLLYFIVSF 167

Query: 2806 SFFLRLIFL 2780
             FF  L FL
Sbjct: 168  QFFFFLSFL 176

>Q16363:LAMA4_HUMAN Laminin subunit alpha-4 precursor - Homo sapiens (Human)|
          Length = 1823

 Score = 34.7 bits (78), Expect = 2.6
 Identities = 34/116 (29%), Positives = 52/116 (44%), Gaps = 5/116 (4%)
 Frame = +2

Query: 1904 AIQYGGSAAHNKIFCEQRGQWKAATQSQEFLRTLQRYYNNAY-TDPEKQDAINVFLGH-- 2074
            A QYGG+A   + F   +G + A +Q    LRT   +    Y +D E+ D + +FL H  
Sbjct: 1469 AYQYGGTANSRQEFEHLKGDFGAKSQFSIRLRTRSSHGMIFYVSDQEENDFMTLFLAHGR 1528

Query: 2075 --FQPQQGKPPLWKLDSDQHYNIGRQGTLSEETGRFIKRSLSDGNILCENSAPVSD 2236
              +    G   L K+ S + YN G    +     R   R + DG  + E S P ++
Sbjct: 1529 LVYMFNVGHKKL-KIRSQEKYNDGLWHDVIFIRERSSGRLVIDGLRVLEESLPPTE 1583


  Database: uniprot_sprot.fasta.out
    Posted date:  Jul 19, 2007  5:58 PM
  Number of letters in database: 100,686,439
  Number of sequences in database:  274,295
  
Lambda     K      H
   0.318    0.134    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 274295
Number of Hits to DB: 577,443,111
Number of extensions: 13043553
Number of successful extensions: 35959
Number of sequences better than 10.0: 19
Number of HSP's gapped: 35881
Number of HSP's successfully gapped: 30
Length of query: 1067
Length of database: 100,686,439
Length adjustment: 124
Effective length of query: 943
Effective length of database: 66,673,859
Effective search space: 62873449037
Effective search space used: 62873449037
Neighboring words threshold: 12
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)