ナショナルバイオリソースプロジェクト
-Barley Genetic Resources Database-
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| Clone Name | FLbaf12m24 |
|---|---|
| Clone Library Name | barley_pub |
>Q2MHE4:HT1_ARATH Serine/threonine-protein kinase HT1 - Arabidopsis thaliana (Mouse-ear| cress) Length = 390 Score = 266 bits (679), Expect = 5e-70 Identities = 138/321 (42%), Positives = 203/321 (63%), Gaps = 8/321 (2%) Frame = +2 Query: 1757 SSWTRRYFD--NVGRRRVSAVEN----VRSRTVSMAQAVQST-VDWKLDKAKLLVGHSFA 1915 SS T RY + + ++R ++E+ + S V +A + +W D ++L +G+ FA Sbjct: 34 SSKTNRYAEAETMEKKRFDSMESWSMILESENVETWEASKGEREEWTADLSQLFIGNKFA 93 Query: 1916 SGAHSRLYRGLYDDKPVAIKFIRRP-HEDPGGIMAAKLDKQYNTEINALSHLYHKNVIKL 2092 SGAHSR+YRG+Y + VA+K +R P H++ AKL++Q+ +E+ LS L+H N+++ Sbjct: 94 SGAHSRIYRGIYKQRAVAVKMVRIPTHKEE---TRAKLEQQFKSEVALLSRLFHPNIVQF 150 Query: 2093 VATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIALEIARGLEYVHSQGVVH 2272 +A K PVY IITE + G+LR YL+ E L +E + +AL+I+RG+EY+HSQGV+H Sbjct: 151 IAACKKPPVYCIITEYMSQGNLRMYLNKKEPYSLSIETVLRLALDISRGMEYLHSQGVIH 210 Query: 2273 RDIKPENILFDENFEVKIADFGIAXXXXXXXXXXXXXGTYRWMAPEMIKRKPYNRKVDVY 2452 RD+K N+L ++ VK+ADFG + GTYRWMAPEMIK KPY RKVDVY Sbjct: 211 RDLKSNNLLLNDEMRVKVADFGTSCLETQCREAKGNMGTYRWMAPEMIKEKPYTRKVDVY 270 Query: 2453 SFGLLLWEMVTGRIPFENLSPVQVAYAVATDKLKPMDPQDYCPAAVRPLIEQCCALQPEK 2632 SFG++LWE+ T +PF+ ++PVQ A+AVA +P P C A+ LI++C + P K Sbjct: 271 SFGIVLWELTTALLPFQGMTPVQAAFAVAEKNERPPLPAS-CQPALAHLIKRCWSENPSK 329 Query: 2633 RPDFWQLVKTLEKIQSVMSQG 2695 RPDF +V LEK + +G Sbjct: 330 RPDFSNIVAVLEKYDECVKEG 350
>P83104:M3LK7_DROME Putative mitogen-activated protein kinase kinase kinase 7-like -| Drosophila melanogaster (Fruit fly) Length = 393 Score = 145 bits (367), Expect = 7e-34 Identities = 86/273 (31%), Positives = 148/273 (54%), Gaps = 9/273 (3%) Frame = +2 Query: 1874 KLDKAKLLVGHSF-ASGAHSRLYRGLYDDKPVAIKFIRRPHEDPGGIMAAKLDKQYNTEI 2050 ++D A++ + F +G+ + + + ++ +A+K + + K EI Sbjct: 4 QVDFAEVKLSEKFLGAGSGGAVRKATFQNQEIAVKIF--------DFLEETIKKNAEREI 55 Query: 2051 NALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIALEI 2230 LS + H+NVI+++ G Y++ E L GSL +YL+ + +E+ + AL+ Sbjct: 56 THLSEIDHENVIRVIGRASNGKKDYLLMEYLEEGSLHNYLYGDDKWEYTVEQAVRWALQC 115 Query: 2231 ARGLEYVHS--QGVVHRDIKPEN-ILFDENFEVKIADFGIAXXXXXXXXXXXXXGTYRWM 2401 A+ L Y+HS + +VHRDIKP+N +L++++ ++KI DFG+A GT R+M Sbjct: 116 AKALAYLHSLDRPIVHRDIKPQNMLLYNQHEDLKICDFGLATDMSNNKTDMQ--GTLRYM 173 Query: 2402 APEMIKRKPYNRKVDVYSFGLLLWEMVTGRIPFENLSPVQVAYAV-----ATDKLKPMDP 2566 APE IK Y K DVYSFG++LWE++T ++P+ +L YA+ + +KL Sbjct: 174 APEAIKHLKYTAKCDVYSFGIMLWELMTRQLPYSHLENPNSQYAIMKAISSGEKLPMEAV 233 Query: 2567 QDYCPAAVRPLIEQCCALQPEKRPDFWQLVKTL 2665 + CP ++ L+E C + PEKRP ++ K L Sbjct: 234 RSDCPEGIKQLMECCMDINPEKRPSMKEIEKFL 266
>Q7T6Y2:YR831_MIMIV Putative serine/threonine-protein kinase/receptor R831 precursor -| Mimivirus Length = 1624 Score = 145 bits (365), Expect = 1e-33 Identities = 86/302 (28%), Positives = 151/302 (50%), Gaps = 11/302 (3%) Frame = +2 Query: 1868 DWKLDKAKLLVGHSFASGAHSRLYRGLYDDKPVAIKFIRRPHEDPGGIMAAKLDKQYNTE 2047 DW++D ++L +G + +G + +Y+ ++ VA+K I H ++ +++ + E Sbjct: 778 DWEIDFSELEIGETLGTGGYGEVYKSIWKGTEVAVKLISSKH------VSKDMERSFFEE 831 Query: 2048 INALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIALE 2227 + ++ L H NV+ +A P I+ E + GSL L N +P I +A + Sbjct: 832 VKIMTSLRHPNVVLFMAASTKSPNMCIVMEFMSLGSLYDLLGNELIPEIPYALKIKMAYQ 891 Query: 2228 IARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFG---IAXXXXXXXXXXXXXGTYRW 2398 ++G+ ++HS G+VHRD+K N+L D + VK++DFG + GT W Sbjct: 892 ASKGMHFLHSSGIVHRDLKSLNLLLDSKWNVKVSDFGLTKVKSELDKKKTNDNIIGTIHW 951 Query: 2399 MAPEMIKRKPYNRKV--DVYSFGLLLWEMVTGRIPFENLSPVQVAYAVATDKLKPMDPQD 2572 +APE++ + DVYSFG++LWE++T P++ ++P +A +V D ++P + Sbjct: 952 IAPEILNDSTEVDYILADVYSFGIILWELLTREQPYKGMTPAAIAVSVIRDGMRPPISDE 1011 Query: 2573 YCPA---AVRPLIEQCCALQPEKRPDFWQLVKTLEKI---QSVMSQGGSLDTLRSSGHKK 2734 A LI+QC RP F +++ L I S M+ G S +L S G K Sbjct: 1012 AVTAHSIEYIDLIKQCWHSDTIIRPTFLEIMTRLSNILGDSSNMTSGTSSSSLSSGGIGK 1071 Query: 2735 GL 2740 + Sbjct: 1072 SI 1073 Score = 137 bits (344), Expect = 3e-31 Identities = 84/268 (31%), Positives = 143/268 (53%), Gaps = 3/268 (1%) Frame = +2 Query: 1871 WKLDKAKLLVGHSFASGAHSRLYRGLYDDKPVAIK-FIRRPHEDPGGIMAAKLDKQYNTE 2047 W ++ ++ +G G++ ++ G + VA+K F+++ + + ++ E Sbjct: 1357 WIINYDEISIGKQIGLGSYGIVFNGKWKGVDVAVKKFVKQKLSETQLL-------EFRAE 1409 Query: 2048 INALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIALE 2227 + LS L H N++ + P I+TE + G+LR L NP+ + + + + Sbjct: 1410 MAFLSELKHSNIVTFIGACIKKPNICIVTEYMRMGNLRDVLKNPDIK-ITFANKLKLLYG 1468 Query: 2228 IARGLEYVHSQG--VVHRDIKPENILFDENFEVKIADFGIAXXXXXXXXXXXXXGTYRWM 2401 A G++Y+HS +VHRDIKP NIL DE+F VKIADFG A GT W Sbjct: 1469 AAMGIDYLHSSNPMIVHRDIKPANILVDEHFNVKIADFGFARIKEDNTTMTRC-GTPCWT 1527 Query: 2402 APEMIKRKPYNRKVDVYSFGLLLWEMVTGRIPFENLSPVQVAYAVATDKLKPMDPQDYCP 2581 APE+I+ + Y K DV+SFG+++WE++TG+ PF + ++V+ + + +P+ P D CP Sbjct: 1528 APEVIRGEKYCEKADVFSFGVVMWEVLTGKEPFAECNFMKVSLDI-LEGGRPIIPSD-CP 1585 Query: 2582 AAVRPLIEQCCALQPEKRPDFWQLVKTL 2665 LI++C + KRP ++V+ L Sbjct: 1586 HEFAKLIKKCWHAKAHKRPTMTEVVQQL 1613
>Q7T6X2:YR826_MIMIV Putative serine/threonine-protein kinase/receptor R826 precursor -| Mimivirus Length = 1657 Score = 143 bits (360), Expect = 5e-33 Identities = 89/269 (33%), Positives = 141/269 (52%), Gaps = 2/269 (0%) Frame = +2 Query: 1871 WKLDKAKLLVGHSFASGAHSRLYRGLYDDKPVAIKFIRRPHEDPGGIMAAKLDKQYNTEI 2050 W ++ ++ +G G++ +YRG + + VAIK + D ++ + EI Sbjct: 1392 WVINYDEIKMGEQIGLGSYGVVYRGKWKNVDVAIKKFIKQKIDENHLLGIR------EEI 1445 Query: 2051 NALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIALEI 2230 L L+H N+I +V P I+TE + G+LR + + L + I I + I Sbjct: 1446 AFLKKLHHPNIITMVGASLKKPNICIVTEYMAKGNLRDAMRTCTPK-LEWHQKIKILVNI 1504 Query: 2231 ARGLEYVHS--QGVVHRDIKPENILFDENFEVKIADFGIAXXXXXXXXXXXXXGTYRWMA 2404 A+G+ Y+HS ++HRDIKP NIL DEN+ VKIADFG A GT W A Sbjct: 1505 AKGISYLHSFDPPIIHRDIKPSNILIDENWNVKIADFGFARIKEENAIMTRC-GTPCWTA 1563 Query: 2405 PEMIKRKPYNRKVDVYSFGLLLWEMVTGRIPFENLSPVQVAYAVATDKLKPMDPQDYCPA 2584 PE+I+ Y+ KVDV+SFG+++WE++T + PF + +++ + D ++P PQD CP Sbjct: 1564 PEIIRNDIYDEKVDVFSFGIVMWEVLTCKEPFIGANFMKITMDILED-VRPKIPQD-CPE 1621 Query: 2585 AVRPLIEQCCALQPEKRPDFWQLVKTLEK 2671 L+ +C + KRP ++ L K Sbjct: 1622 EFAKLMRKCWHAKSTKRPTMDDVIIVLAK 1650 Score = 139 bits (349), Expect = 9e-32 Identities = 83/298 (27%), Positives = 146/298 (48%), Gaps = 11/298 (3%) Frame = +2 Query: 1868 DWKLDKAKLLVGHSFASGAHSRLYRGLYDDKPVAIKFIRRPHEDPGGIMAAKLDKQYNTE 2047 DW++D +L +G +GA +++G + VA+K I P + +++ + E Sbjct: 778 DWEIDFHELELGEQLGTGAFGEVHKGTWRGTEVAVKMI-----SPDKTITKDIERNFKDE 832 Query: 2048 INALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIALE 2227 + ++ L H NV+ +A P I+ E + GSL L N +P + IA + Sbjct: 833 VRVMTTLRHPNVVLFMAASTKPPKMCIVMEFMALGSLHDLLKNELIPDIPFALKVKIAYQ 892 Query: 2228 IARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIA--XXXXXXXXXXXXXGTYRWM 2401 ++G+ ++HS G+ HRD+K N+L D + VK++DFG+ GT +W Sbjct: 893 ASKGMHFLHSSGITHRDLKSLNLLLDIKWNVKVSDFGLTKFKSDVKSINPEKFAGTIQWT 952 Query: 2402 APEMIKRKPYNRKV-----DVYSFGLLLWEMVTGRIPFENLSPVQVAYAVATDKLKPMDP 2566 APE++ +R+V DVYSFG+++WE++T P+ +SP +A +V D +P+ Sbjct: 953 APEILSE---DREVDYILSDVYSFGIIMWELITRDQPYFGMSPAAIAVSVIRDNYRPV-I 1008 Query: 2567 QDYCPAAVRP----LIEQCCALQPEKRPDFWQLVKTLEKIQSVMSQGGSLDTLRSSGH 2728 D + V P L+ C P RP F ++ + ++ ++M G SS + Sbjct: 1009 SDQLRSEVAPEYIELLTSCWHFDPTIRPTFLEI---MTRLSNLMGDSGMTGMSSSSSN 1063
>Q95UN8:M3KSL_DROME Mitogen-activated protein kinase kinase kinase - Drosophila| melanogaster (Fruit fly) Length = 1161 Score = 141 bits (356), Expect = 1e-32 Identities = 96/319 (30%), Positives = 154/319 (48%), Gaps = 15/319 (4%) Frame = +2 Query: 1763 WTRRYFDNVGRRRVSAVENVRSRTVSMAQAVQSTVDWKLDKAKLLVGHSFASGAHSRLYR 1942 WT + D VG V + ++++ A+ +++ +L + SG +++R Sbjct: 99 WTGKIGDKVGVFPKDFVTDEDPLQLNVSSAIGDIQPHEIEYNELDIKEVIGSGGFCKVHR 158 Query: 1943 GLYDDKPVAIKFIRRPHEDPGGIMAAKLDKQYNTEINALSHLYHKNVIKL----VATHKC 2110 G YD + VAIK + ED ++ E L H+N+ L + T C Sbjct: 159 GYYDGEEVAIKIAHQTGEDD----MQRMRDNVLQEAKLFWALKHENIAALRGVCLNTKLC 214 Query: 2111 GPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIALEIARGLEYVHSQG---VVHRDI 2281 ++ E GGSL L +P + ++ A++IARG+ Y+H++ ++HRD+ Sbjct: 215 -----LVMEYARGGSLNRILAGK----IPPDVLVNWAIQIARGMNYLHNEAPMSIIHRDL 265 Query: 2282 KPENILFDENFE--------VKIADFGIAXXXXXXXXXXXXXGTYRWMAPEMIKRKPYNR 2437 K N+L E E +KI DFG+A GTY WM PE+I Y++ Sbjct: 266 KSSNVLIYEAIEGNHLQQKTLKITDFGLAREMYNTQRMSAA-GTYAWMPPEVISVSTYSK 324 Query: 2438 KVDVYSFGLLLWEMVTGRIPFENLSPVQVAYAVATDKLKPMDPQDYCPAAVRPLIEQCCA 2617 DV+S+G+LLWE++TG P++ P+ VAY VA + L P+ CP L++ C Sbjct: 325 FSDVWSYGVLLWELITGETPYKGFDPLSVAYGVAVNTLTLPIPKT-CPETWGALMKSCWQ 383 Query: 2618 LQPEKRPDFWQLVKTLEKI 2674 P KRP F +++K LE I Sbjct: 384 TDPHKRPGFKEILKQLESI 402
>Q66HA1:M3K11_RAT Mitogen-activated protein kinase kinase kinase 11 - Rattus norvegicus| (Rat) Length = 850 Score = 141 bits (356), Expect = 1e-32 Identities = 95/292 (32%), Positives = 149/292 (51%), Gaps = 11/292 (3%) Frame = +2 Query: 1919 GAHSRLYRGLYDDKPVAIKFIRRPHEDPGGIMAAKLDKQYNTEINALSHLYHKNVIKLVA 2098 G ++YRG + + VA+K R+ ++ + A + + E + L H N+I L A Sbjct: 127 GGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQ----EARLFAMLAHPNIIALKA 182 Query: 2099 THKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIALEIARGLEYVHSQG---VV 2269 P ++ E GG L L R +P ++ A++IARG+ Y+H + V+ Sbjct: 183 VCLEEPNLCLVMEYAAGGPLSRALAG---RRVPPHVLVNWAVQIARGMHYLHCEALVPVI 239 Query: 2270 HRDIKPENILFDENFE--------VKIADFGIAXXXXXXXXXXXXXGTYRWMAPEMIKRK 2425 HRD+K NIL + E +KI DFG+A GTY WMAPE+IK Sbjct: 240 HRDLKSNNILLLQPIEGDDMEHKTLKITDFGLAREWHKTTQMSAA-GTYAWMAPEVIKAS 298 Query: 2426 PYNRKVDVYSFGLLLWEMVTGRIPFENLSPVQVAYAVATDKLKPMDPQDYCPAAVRPLIE 2605 +++ DV+SFG+LLWE++TG +P+ + + VAY VA +KL P CP L+ Sbjct: 299 TFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPST-CPEPFAQLMA 357 Query: 2606 QCCALQPEKRPDFWQLVKTLEKIQSVMSQGGSLDTLRSSGHKKGLKHWIQKL 2761 C A P +RPDF +++ LE +++ + + D+ S ++G K IQ L Sbjct: 358 DCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSM--QEGWKREIQGL 407
>Q80XI6:M3K11_MOUSE Mitogen-activated protein kinase kinase kinase 11 - Mus musculus| (Mouse) Length = 850 Score = 141 bits (356), Expect = 1e-32 Identities = 95/292 (32%), Positives = 149/292 (51%), Gaps = 11/292 (3%) Frame = +2 Query: 1919 GAHSRLYRGLYDDKPVAIKFIRRPHEDPGGIMAAKLDKQYNTEINALSHLYHKNVIKLVA 2098 G ++YRG + + VA+K R+ ++ + A + + E + L H N+I L A Sbjct: 127 GGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQ----EARLFAMLAHPNIIALKA 182 Query: 2099 THKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIALEIARGLEYVHSQG---VV 2269 P ++ E GG L L R +P ++ A++IARG+ Y+H + V+ Sbjct: 183 VCLEEPNLCLVMEYAAGGPLSRALAG---RRVPPHVLVNWAVQIARGMHYLHCEALVPVI 239 Query: 2270 HRDIKPENILFDENFE--------VKIADFGIAXXXXXXXXXXXXXGTYRWMAPEMIKRK 2425 HRD+K NIL + E +KI DFG+A GTY WMAPE+IK Sbjct: 240 HRDLKSNNILLLQPIEGDDMEHKTLKITDFGLAREWHKTTQMSAA-GTYAWMAPEVIKAS 298 Query: 2426 PYNRKVDVYSFGLLLWEMVTGRIPFENLSPVQVAYAVATDKLKPMDPQDYCPAAVRPLIE 2605 +++ DV+SFG+LLWE++TG +P+ + + VAY VA +KL P CP L+ Sbjct: 299 TFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPST-CPEPFAQLMA 357 Query: 2606 QCCALQPEKRPDFWQLVKTLEKIQSVMSQGGSLDTLRSSGHKKGLKHWIQKL 2761 C A P +RPDF +++ LE +++ + + D+ S ++G K IQ L Sbjct: 358 DCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSM--QEGWKREIQGL 407
>Q16584:M3K11_HUMAN Mitogen-activated protein kinase kinase kinase 11 - Homo sapiens| (Human) Length = 847 Score = 141 bits (356), Expect = 1e-32 Identities = 95/292 (32%), Positives = 149/292 (51%), Gaps = 11/292 (3%) Frame = +2 Query: 1919 GAHSRLYRGLYDDKPVAIKFIRRPHEDPGGIMAAKLDKQYNTEINALSHLYHKNVIKLVA 2098 G ++YRG + + VA+K R+ ++ + A + + E + L H N+I L A Sbjct: 126 GGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQ----EARLFAMLAHPNIIALKA 181 Query: 2099 THKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIALEIARGLEYVHSQG---VV 2269 P ++ E GG L L R +P ++ A++IARG+ Y+H + V+ Sbjct: 182 VCLEEPNLCLVMEYAAGGPLSRALAG---RRVPPHVLVNWAVQIARGMHYLHCEALVPVI 238 Query: 2270 HRDIKPENILFDENFE--------VKIADFGIAXXXXXXXXXXXXXGTYRWMAPEMIKRK 2425 HRD+K NIL + E +KI DFG+A GTY WMAPE+IK Sbjct: 239 HRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAA-GTYAWMAPEVIKAS 297 Query: 2426 PYNRKVDVYSFGLLLWEMVTGRIPFENLSPVQVAYAVATDKLKPMDPQDYCPAAVRPLIE 2605 +++ DV+SFG+LLWE++TG +P+ + + VAY VA +KL P CP L+ Sbjct: 298 TFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPST-CPEPFAQLMA 356 Query: 2606 QCCALQPEKRPDFWQLVKTLEKIQSVMSQGGSLDTLRSSGHKKGLKHWIQKL 2761 C A P +RPDF +++ LE +++ + + D+ S ++G K IQ L Sbjct: 357 DCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSM--QEGWKREIQGL 406
>Q66L42:M3K10_MOUSE Mitogen-activated protein kinase kinase kinase 10 - Mus musculus| (Mouse) Length = 940 Score = 140 bits (352), Expect = 4e-32 Identities = 90/265 (33%), Positives = 134/265 (50%), Gaps = 12/265 (4%) Frame = +2 Query: 1919 GAHSRLYRGLYDDKPVAIKFIRR-PHEDPGGIMAAKLDKQYNTEINALSHLYHKNVIKLV 2095 G ++YR ++ + VA+K R P DP A +Q E L H N+I L Sbjct: 107 GGFGKVYRAVWRGEEVAVKAARLDPERDP-----AVTAEQVRQEARLFGALQHPNIIALR 161 Query: 2096 ATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIALEIARGLEYVHSQG---V 2266 P ++ E GG+L L R +P ++ A+++ARG+ Y+H+ + Sbjct: 162 GACLSPPNLCLVMEYARGGALSRVLAG---RRVPPHVLVNWAVQVARGMNYLHNDAPVPI 218 Query: 2267 VHRDIKPENILFDENFE--------VKIADFGIAXXXXXXXXXXXXXGTYRWMAPEMIKR 2422 +HRD+K NIL E E +KI DFG+A GTY WMAPE+I+ Sbjct: 219 IHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHKTTKMSAA-GTYAWMAPEVIRL 277 Query: 2423 KPYNRKVDVYSFGLLLWEMVTGRIPFENLSPVQVAYAVATDKLKPMDPQDYCPAAVRPLI 2602 +++ DV+SFG+LLWE++TG +P+ + + VAY VA +KL P CP L+ Sbjct: 278 SLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPST-CPEPFARLL 336 Query: 2603 EQCCALQPEKRPDFWQLVKTLEKIQ 2677 E+C P RPDF ++K LE I+ Sbjct: 337 EECWDPDPHGRPDFGSILKQLEVIE 361
>Q13882:PTK6_HUMAN Tyrosine-protein kinase 6 - Homo sapiens (Human)| Length = 451 Score = 139 bits (351), Expect = 5e-32 Identities = 89/274 (32%), Positives = 134/274 (48%), Gaps = 3/274 (1%) Frame = +2 Query: 1868 DWKLDKAKLLVGHSFASGAHSRLYRGLYDDK-PVAIKFIRRPHEDPGGIMAAKLDKQYNT 2044 DW+ + + + SG ++ GL+ D+ VAIK I R + + + Sbjct: 183 DWERPREEFTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDN--------LLHQQMLQS 234 Query: 2045 EINALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIAL 2224 EI A+ L HK+++ L A G YIITEL+ GSL L + + + LP+ + IA Sbjct: 235 EIQAMKKLRHKHILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAW 294 Query: 2225 EIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIAXXXXXXXXXXXXXG-TYRWM 2401 ++A G+ Y+ SQ +HRD+ NIL EN K+ DFG+A Y+W Sbjct: 295 QVAEGMCYLESQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDHNIPYKWT 354 Query: 2402 APEMIKRKPYNRKVDVYSFGLLLWEMVT-GRIPFENLSPVQVAYAVATDKLKPMDPQDYC 2578 APE + R Y+ K DV+SFG+LL EM + G++P+ +S + V P + C Sbjct: 355 APEALSRGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLE--C 412 Query: 2579 PAAVRPLIEQCCALQPEKRPDFWQLVKTLEKIQS 2680 P +V L+ C PE+RP F L + L S Sbjct: 413 PPSVHKLMLTCWCRDPEQRPCFKALRERLSSFTS 446
>Q02779:M3K10_HUMAN Mitogen-activated protein kinase kinase kinase 10 - Homo sapiens| (Human) Length = 954 Score = 139 bits (351), Expect = 5e-32 Identities = 91/265 (34%), Positives = 135/265 (50%), Gaps = 12/265 (4%) Frame = +2 Query: 1919 GAHSRLYRGLYDDKPVAIKFIRR-PHEDPGGIMAAKLDKQYNTEINALSHLYHKNVIKLV 2095 G ++YR L+ + VA+K R P +DP A +Q E L H N+I L Sbjct: 107 GGFGKVYRALWRGEEVAVKAARLDPEKDP-----AVTAEQVCQEARLFGALQHPNIIALR 161 Query: 2096 ATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIALEIARGLEYVHSQG---V 2266 P ++ E GG+L L R +P ++ A+++ARG+ Y+H+ + Sbjct: 162 GACLNPPHLCLVMEYARGGALSRVLAG---RRVPPHVLVNWAVQVARGMNYLHNDAPVPI 218 Query: 2267 VHRDIKPENILFDENFE--------VKIADFGIAXXXXXXXXXXXXXGTYRWMAPEMIKR 2422 +HRD+K NIL E E +KI DFG+A GTY WMAPE+I+ Sbjct: 219 IHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHKTTKMSAA-GTYAWMAPEVIRL 277 Query: 2423 KPYNRKVDVYSFGLLLWEMVTGRIPFENLSPVQVAYAVATDKLKPMDPQDYCPAAVRPLI 2602 +++ DV+SFG+LLWE++TG +P+ + + VAY VA +KL P CP L+ Sbjct: 278 SLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPST-CPEPFARLL 336 Query: 2603 EQCCALQPEKRPDFWQLVKTLEKIQ 2677 E+C P RPDF ++K LE I+ Sbjct: 337 EECWDPDPHGRPDFGSILKRLEVIE 361
>P10533:RMIL_AVII1 Serine/threonine-protein kinase-transforming protein Rmil - Avian| retrovirus IC10 Length = 367 Score = 138 bits (348), Expect = 1e-31 Identities = 88/300 (29%), Positives = 159/300 (53%), Gaps = 9/300 (3%) Frame = +2 Query: 1796 RRVSAVENVRSRTVSMAQAVQSTVDWKLDKAKLLVGHSFASGAHSRLYRGLYDDKPVAIK 1975 R+ S+ R+R ++ + S+ DW++ ++ VG SG+ +Y+G + VA+K Sbjct: 36 RKSSSSSEDRNRMKTLGRR-DSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGD-VAVK 93 Query: 1976 FIRRPHEDPGGIMAAKLDKQYNTEINALSHLYHKNVIKLVATHKCGPVYYIITELLPGGS 2155 + P + A K E+ L H N++ L + P I+T+ G S Sbjct: 94 MLNVTAPTPQQLQAFK------NEVGVLRKTRHVNIL-LFMGYSTKPQLAIVTQWCEGSS 146 Query: 2156 LRSYLHNPEHRPLPLERTISIALEIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADF 2335 L +LH E + + + I IA + A+G++Y+H++ ++HRD+K NI E+ VKI DF Sbjct: 147 LYHHLHIIETK-FEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDF 205 Query: 2336 GIA---XXXXXXXXXXXXXGTYRWMAPEMIK---RKPYNRKVDVYSFGLLLWEMVTGRIP 2497 G+A G+ WMAPE+I+ + PY+ + DVY+FG++L+E++TG++P Sbjct: 206 GLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLP 265 Query: 2498 FENL-SPVQVAYAVATDKLKP--MDPQDYCPAAVRPLIEQCCALQPEKRPDFWQLVKTLE 2668 + N+ + Q+ + V L P + CP A++ L+ +C + ++RP F Q++ ++E Sbjct: 266 YSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIE 325
>P27966:RMIL_AVEVR Serine/threonine-protein kinase-transforming protein Rmil - Avian| rous-associated virus type 1 Length = 450 Score = 138 bits (348), Expect = 1e-31 Identities = 88/300 (29%), Positives = 159/300 (53%), Gaps = 9/300 (3%) Frame = +2 Query: 1796 RRVSAVENVRSRTVSMAQAVQSTVDWKLDKAKLLVGHSFASGAHSRLYRGLYDDKPVAIK 1975 R+ S+ R+R ++ + S+ DW++ ++ VG SG+ +Y+G + VA+K Sbjct: 52 RKSSSSSEDRNRMKTLGRR-DSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGD-VAVK 109 Query: 1976 FIRRPHEDPGGIMAAKLDKQYNTEINALSHLYHKNVIKLVATHKCGPVYYIITELLPGGS 2155 + P + A K E+ L H N++ L + P I+T+ G S Sbjct: 110 MLNVTAPTPQQLQAFK------NEVGVLRKTRHVNIL-LFMGYSTKPQLAIVTQWCEGSS 162 Query: 2156 LRSYLHNPEHRPLPLERTISIALEIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADF 2335 L +LH E + + + I IA + A+G++Y+H++ ++HRD+K NI E+ VKI DF Sbjct: 163 LYHHLHIIETK-FEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDF 221 Query: 2336 GIA---XXXXXXXXXXXXXGTYRWMAPEMIK---RKPYNRKVDVYSFGLLLWEMVTGRIP 2497 G+A G+ WMAPE+I+ + PY+ + DVY+FG++L+E++TG++P Sbjct: 222 GLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLP 281 Query: 2498 FENL-SPVQVAYAVATDKLKP--MDPQDYCPAAVRPLIEQCCALQPEKRPDFWQLVKTLE 2668 + N+ + Q+ + V L P + CP A++ L+ +C + ++RP F Q++ ++E Sbjct: 282 YSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIE 341
>P15056:BRAF1_HUMAN B-Raf proto-oncogene serine/threonine-protein kinase - Homo sapiens| (Human) Length = 766 Score = 138 bits (348), Expect = 1e-31 Identities = 88/300 (29%), Positives = 159/300 (53%), Gaps = 9/300 (3%) Frame = +2 Query: 1796 RRVSAVENVRSRTVSMAQAVQSTVDWKLDKAKLLVGHSFASGAHSRLYRGLYDDKPVAIK 1975 R+ S+ R+R ++ + S+ DW++ ++ VG SG+ +Y+G + VA+K Sbjct: 426 RKSSSSSEDRNRMKTLGRR-DSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGD-VAVK 483 Query: 1976 FIRRPHEDPGGIMAAKLDKQYNTEINALSHLYHKNVIKLVATHKCGPVYYIITELLPGGS 2155 + P + A K E+ L H N++ L + P I+T+ G S Sbjct: 484 MLNVTAPTPQQLQAFK------NEVGVLRKTRHVNIL-LFMGYSTKPQLAIVTQWCEGSS 536 Query: 2156 LRSYLHNPEHRPLPLERTISIALEIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADF 2335 L +LH E + + + I IA + A+G++Y+H++ ++HRD+K NI E+ VKI DF Sbjct: 537 LYHHLHIIETK-FEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDF 595 Query: 2336 GIA---XXXXXXXXXXXXXGTYRWMAPEMIK---RKPYNRKVDVYSFGLLLWEMVTGRIP 2497 G+A G+ WMAPE+I+ + PY+ + DVY+FG++L+E++TG++P Sbjct: 596 GLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLP 655 Query: 2498 FENL-SPVQVAYAVATDKLKP--MDPQDYCPAAVRPLIEQCCALQPEKRPDFWQLVKTLE 2668 + N+ + Q+ + V L P + CP A++ L+ +C + ++RP F Q++ ++E Sbjct: 656 YSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIE 715
>P34908:BRAF1_COTJA B-Raf proto-oncogene serine/threonine-protein kinase - Coturnix| coturnix japonica (Japanese quail) Length = 807 Score = 138 bits (348), Expect = 1e-31 Identities = 88/300 (29%), Positives = 159/300 (53%), Gaps = 9/300 (3%) Frame = +2 Query: 1796 RRVSAVENVRSRTVSMAQAVQSTVDWKLDKAKLLVGHSFASGAHSRLYRGLYDDKPVAIK 1975 R+ S+ R+R ++ + S+ DW++ ++ VG SG+ +Y+G + VA+K Sbjct: 466 RKSSSSSEDRNRMKTLGRR-DSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGD-VAVK 523 Query: 1976 FIRRPHEDPGGIMAAKLDKQYNTEINALSHLYHKNVIKLVATHKCGPVYYIITELLPGGS 2155 + P + A K E+ L H N++ L + P I+T+ G S Sbjct: 524 MLNVTAPTPQQLQAFK------NEVGVLRKTRHVNIL-LFMGYSTKPQLAIVTQWCEGSS 576 Query: 2156 LRSYLHNPEHRPLPLERTISIALEIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADF 2335 L +LH E + + + I IA + A+G++Y+H++ ++HRD+K NI E+ VKI DF Sbjct: 577 LYHHLHIIETK-FEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDF 635 Query: 2336 GIA---XXXXXXXXXXXXXGTYRWMAPEMIK---RKPYNRKVDVYSFGLLLWEMVTGRIP 2497 G+A G+ WMAPE+I+ + PY+ + DVY+FG++L+E++TG++P Sbjct: 636 GLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLP 695 Query: 2498 FENL-SPVQVAYAVATDKLKP--MDPQDYCPAAVRPLIEQCCALQPEKRPDFWQLVKTLE 2668 + N+ + Q+ + V L P + CP A++ L+ +C + ++RP F Q++ ++E Sbjct: 696 YSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIE 755
>Q04982:BRAF1_CHICK B-Raf proto-oncogene serine/threonine-protein kinase - Gallus gallus| (Chicken) Length = 806 Score = 138 bits (348), Expect = 1e-31 Identities = 88/300 (29%), Positives = 159/300 (53%), Gaps = 9/300 (3%) Frame = +2 Query: 1796 RRVSAVENVRSRTVSMAQAVQSTVDWKLDKAKLLVGHSFASGAHSRLYRGLYDDKPVAIK 1975 R+ S+ R+R ++ + S+ DW++ ++ VG SG+ +Y+G + VA+K Sbjct: 466 RKSSSSSEDRNRMKTLGRR-DSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGD-VAVK 523 Query: 1976 FIRRPHEDPGGIMAAKLDKQYNTEINALSHLYHKNVIKLVATHKCGPVYYIITELLPGGS 2155 + P + A K E+ L H N++ L + P I+T+ G S Sbjct: 524 MLNVTAPTPQQLQAFK------NEVGVLRKTRHVNIL-LFMGYSTKPQLAIVTQWCEGSS 576 Query: 2156 LRSYLHNPEHRPLPLERTISIALEIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADF 2335 L +LH E + + + I IA + A+G++Y+H++ ++HRD+K NI E+ VKI DF Sbjct: 577 LYHHLHIIETK-FEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDF 635 Query: 2336 GIA---XXXXXXXXXXXXXGTYRWMAPEMIK---RKPYNRKVDVYSFGLLLWEMVTGRIP 2497 G+A G+ WMAPE+I+ + PY+ + DVY+FG++L+E++TG++P Sbjct: 636 GLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLP 695 Query: 2498 FENL-SPVQVAYAVATDKLKP--MDPQDYCPAAVRPLIEQCCALQPEKRPDFWQLVKTLE 2668 + N+ + Q+ + V L P + CP A++ L+ +C + ++RP F Q++ ++E Sbjct: 696 YSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIE 755
>P28028:BRAF1_MOUSE B-Raf proto-oncogene serine/threonine-protein kinase - Mus musculus| (Mouse) Length = 804 Score = 137 bits (346), Expect = 2e-31 Identities = 87/291 (29%), Positives = 155/291 (53%), Gaps = 9/291 (3%) Frame = +2 Query: 1823 RSRTVSMAQAVQSTVDWKLDKAKLLVGHSFASGAHSRLYRGLYDDKPVAIKFIRRPHEDP 2002 RSR ++ + S+ DW++ ++ VG SG+ +Y+G + VA+K + P Sbjct: 472 RSRMKTLGRR-DSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGD-VAVKMLNVTAPTP 529 Query: 2003 GGIMAAKLDKQYNTEINALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPE 2182 + A K E+ L H N++ L + P I+T+ G SL +LH E Sbjct: 530 QQLQAFK------NEVGVLRKTRHVNIL-LFMGYSTKPQLAIVTQWCEGSSLYHHLHIIE 582 Query: 2183 HRPLPLERTISIALEIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIA---XXX 2353 + + + I IA + A+G++Y+H++ ++HRD+K NI E+ VKI DFG+A Sbjct: 583 TK-FEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRW 641 Query: 2354 XXXXXXXXXXGTYRWMAPEMIK---RKPYNRKVDVYSFGLLLWEMVTGRIPFENL-SPVQ 2521 G+ WMAPE+I+ + PY+ + DVY+FG++L+E++TG++P+ N+ + Q Sbjct: 642 SGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQ 701 Query: 2522 VAYAVATDKLKP--MDPQDYCPAAVRPLIEQCCALQPEKRPDFWQLVKTLE 2668 + + V L P + CP A++ L+ +C + ++RP F Q++ ++E Sbjct: 702 IIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIE 752
>P80192:M3K9_HUMAN Mitogen-activated protein kinase kinase kinase 9 - Homo sapiens| (Human) Length = 1104 Score = 135 bits (341), Expect = 8e-31 Identities = 95/310 (30%), Positives = 149/310 (48%), Gaps = 14/310 (4%) Frame = +2 Query: 1874 KLDKAKLLVGHSFASGAHSRLYRGLYDDKPVAIKFIRR-PHEDPGGIMAAKLDKQYNTEI 2050 ++D A+L + G ++YR + VA+K R P ED ++ + E Sbjct: 138 EIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDED-----ISQTIENVRQEA 192 Query: 2051 NALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIALEI 2230 + L H N+I L P ++ E GG L L + +P + ++ A++I Sbjct: 193 KLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSG---KRIPPDILVNWAVQI 249 Query: 2231 ARGLEYVHSQGVV---HRDIKPENILFDENFE--------VKIADFGIAXXXXXXXXXXX 2377 ARG+ Y+H + +V HRD+K NIL + E +KI DFG+A Sbjct: 250 ARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSA 309 Query: 2378 XXGTYRWMAPEMIKRKPYNRKVDVYSFGLLLWEMVTGRIPFENLSPVQVAYAVATDKLKP 2557 GTY WMAPE+I+ +++ DV+S+G+LLWE++TG +PF + + VAY VA +KL Sbjct: 310 A-GTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLAL 368 Query: 2558 MDPQDYCPAAVRPLIEQCCALQPEKRPDFWQLVKTLEKIQSVMSQGGSLDTLRSSGH--K 2731 P CP L+E C P RP F ++ L I+ + G + + S H + Sbjct: 369 PIPST-CPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIE----ESGFFEMPKDSFHCLQ 423 Query: 2732 KGLKHWIQKL 2761 KH IQ++ Sbjct: 424 DNWKHEIQEM 433
>Q9ESL4:MLTK_MOUSE Mitogen-activated protein kinase kinase kinase MLT - Mus musculus| (Mouse) Length = 802 Score = 135 bits (339), Expect = 1e-30 Identities = 82/259 (31%), Positives = 134/259 (51%), Gaps = 5/259 (1%) Frame = +2 Query: 1919 GAHSRLYRGLY--DDKPVAIKFIRRPHEDPGGIMAAKLDKQYNTEINALSHLYHKNVIKL 2092 G+ +YR + DK VA+K + K++K E LS L H+N+I+ Sbjct: 25 GSFGSVYRAKWISQDKEVAVKKL------------LKIEK----EAEILSVLSHRNIIQF 68 Query: 2093 VATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIALEIARGLEYVHSQG--- 2263 P Y I+TE GSL Y+++ + +E ++ A ++A+G+ Y+H + Sbjct: 69 YGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMEHIMTWATDVAKGMHYLHMEAPVK 128 Query: 2264 VVHRDIKPENILFDENFEVKIADFGIAXXXXXXXXXXXXXGTYRWMAPEMIKRKPYNRKV 2443 V+HRD+K N++ + +KI DFG A GT+ WMAPE+I+ P + Sbjct: 129 VIHRDLKSRNVVIAADGVLKICDFG-ASRFHNHTTHMSLVGTFPWMAPEVIQSLPVSETC 187 Query: 2444 DVYSFGLLLWEMVTGRIPFENLSPVQVAYAVATDKLKPMDPQDYCPAAVRPLIEQCCALQ 2623 D YS+G++LWEM+T +PF+ L +QVA+ V +K + + CP + L+ QC Sbjct: 188 DTYSYGVVLWEMLTREVPFKGLEGLQVAWLV-VEKNERLTIPSSCPRSFAELLHQCWEAD 246 Query: 2624 PEKRPDFWQLVKTLEKIQS 2680 +KRP F Q++ LE + + Sbjct: 247 AKKRPSFKQIISILESMSN 265
>Q63796:M3K12_RAT Mitogen-activated protein kinase kinase kinase 12 - Rattus norvegicus| (Rat) Length = 888 Score = 135 bits (339), Expect = 1e-30 Identities = 80/266 (30%), Positives = 130/266 (48%) Frame = +2 Query: 1871 WKLDKAKLLVGHSFASGAHSRLYRGLYDDKPVAIKFIRRPHEDPGGIMAAKLDKQYNTEI 2050 W++ ++L SGA ++ G + + VA+K +R E T+I Sbjct: 151 WEVPFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKE---------------TDI 195 Query: 2051 NALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIALEI 2230 L L H N+I P Y I+ E G L L RP+ + ++ I Sbjct: 196 KHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLR--AGRPVTPSLLVDWSMGI 253 Query: 2231 ARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIAXXXXXXXXXXXXXGTYRWMAPE 2410 A G+ Y+H ++HRD+K N+L + VKI+DFG + GT WMAPE Sbjct: 254 AGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPE 313 Query: 2411 MIKRKPYNRKVDVYSFGLLLWEMVTGRIPFENLSPVQVAYAVATDKLKPMDPQDYCPAAV 2590 +I+ +P + KVD++SFG++LWE++TG IP++++ + + V ++ L P CP Sbjct: 314 VIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSS-CPDGF 372 Query: 2591 RPLIEQCCALQPEKRPDFWQLVKTLE 2668 + L+ QC +P RP F Q++ L+ Sbjct: 373 KILLRQCWNRKPRNRPSFRQILLHLD 398
>Q60700:M3K12_MOUSE Mitogen-activated protein kinase kinase kinase 12 - Mus musculus| (Mouse) Length = 888 Score = 135 bits (339), Expect = 1e-30 Identities = 80/266 (30%), Positives = 130/266 (48%) Frame = +2 Query: 1871 WKLDKAKLLVGHSFASGAHSRLYRGLYDDKPVAIKFIRRPHEDPGGIMAAKLDKQYNTEI 2050 W++ ++L SGA ++ G + + VA+K +R E T+I Sbjct: 151 WEVPFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKE---------------TDI 195 Query: 2051 NALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIALEI 2230 L L H N+I P Y I+ E G L L RP+ + ++ I Sbjct: 196 KHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLR--AGRPVTPSLLVDWSMGI 253 Query: 2231 ARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIAXXXXXXXXXXXXXGTYRWMAPE 2410 A G+ Y+H ++HRD+K N+L + VKI+DFG + GT WMAPE Sbjct: 254 AGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPE 313 Query: 2411 MIKRKPYNRKVDVYSFGLLLWEMVTGRIPFENLSPVQVAYAVATDKLKPMDPQDYCPAAV 2590 +I+ +P + KVD++SFG++LWE++TG IP++++ + + V ++ L P CP Sbjct: 314 VIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSS-CPDGF 372 Query: 2591 RPLIEQCCALQPEKRPDFWQLVKTLE 2668 + L+ QC +P RP F Q++ L+ Sbjct: 373 KILLRQCWNSKPRNRPSFRQILLHLD 398
>Q12852:M3K12_HUMAN Mitogen-activated protein kinase kinase kinase 12 - Homo sapiens| (Human) Length = 859 Score = 135 bits (339), Expect = 1e-30 Identities = 80/266 (30%), Positives = 130/266 (48%) Frame = +2 Query: 1871 WKLDKAKLLVGHSFASGAHSRLYRGLYDDKPVAIKFIRRPHEDPGGIMAAKLDKQYNTEI 2050 W++ ++L SGA ++ G + + VA+K +R E T+I Sbjct: 118 WEVPFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKE---------------TDI 162 Query: 2051 NALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIALEI 2230 L L H N+I P Y I+ E G L L RP+ + ++ I Sbjct: 163 KHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLR--AGRPVTPSLLVDWSMGI 220 Query: 2231 ARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIAXXXXXXXXXXXXXGTYRWMAPE 2410 A G+ Y+H ++HRD+K N+L + VKI+DFG + GT WMAPE Sbjct: 221 AGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPE 280 Query: 2411 MIKRKPYNRKVDVYSFGLLLWEMVTGRIPFENLSPVQVAYAVATDKLKPMDPQDYCPAAV 2590 +I+ +P + KVD++SFG++LWE++TG IP++++ + + V ++ L P CP Sbjct: 281 VIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSS-CPDGF 339 Query: 2591 RPLIEQCCALQPEKRPDFWQLVKTLE 2668 + L+ QC +P RP F Q++ L+ Sbjct: 340 KILLRQCWNSKPRNRPSFRQILLHLD 365
>Q7T2V3:M3K10_XENLA Mitogen-activated protein kinase kinase kinase 10 - Xenopus laevis| (African clawed frog) Length = 1005 Score = 134 bits (338), Expect = 2e-30 Identities = 95/322 (29%), Positives = 153/322 (47%), Gaps = 12/322 (3%) Frame = +2 Query: 1763 WTRRYFDNVGRRRVSAVENVRSRTVSMAQAVQSTVDWKLDKAKLLVGHSFASGAHSRLYR 1942 WT + D VG + V + T Q + +++ +L + G ++Y+ Sbjct: 75 WTGKIKDKVGIFPSNYVVSDDKYTTLTGAPKQCPLPLEIEFDELNLDEIIGVGGFGKVYK 134 Query: 1943 GLYDDKPVAIKFIRRPHEDPGGIMAAKLDKQYNTEINALSHLYHKNVIKLVATHKCGPVY 2122 GL+ D+ VA+K +R ++ + A + + E L H N+I L P Sbjct: 135 GLWRDEEVAVKAVRHDPDEDINVTAENVRQ----EAKIFCMLCHPNIIALTGVCLKPPHL 190 Query: 2123 YIITELLPGGSLRSYLHNPEHRPLPLERTISIALEIARGLEYVHSQGVV---HRDIKPEN 2293 ++ E GG L L + +P ++ A++IA+G+ Y+H++ +V HRD+ N Sbjct: 191 CLVMEYARGGPLHRALAG---KKVPAHVLVNWAVQIAKGMTYLHNEAIVPIIHRDLGSSN 247 Query: 2294 ILFDENFE--------VKIADFGIAXXXXXXXXXXXXXGTYRWMAPEMIKRKPYNRKVDV 2449 IL E E + I DFG+A GTY WMAPE+I+ +++ DV Sbjct: 248 ILILEKAENDDLFNKTLNITDFGLAREWQKTTKMSAA-GTYAWMAPEVIRLSLFSKSSDV 306 Query: 2450 YSFGLLLWEMVTGRIPFENLSPVQVAYAVATDKLKPMDPQDYCPAAVRPLIEQCCALQPE 2629 +SFG+LLWE++TG +P+ + + VAY VA +KL P CP ++E C P Sbjct: 307 WSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPST-CPEPFVRILEACWDPDPH 365 Query: 2630 KRPDFWQLVKTLEKI-QSVMSQ 2692 RP F +++ L I QS M Q Sbjct: 366 SRPTFSCILEQLTTIEQSAMFQ 387
>Q3U1V8:M3K9_MOUSE Mitogen-activated protein kinase kinase kinase 9 - Mus musculus| (Mouse) Length = 1077 Score = 134 bits (337), Expect = 2e-30 Identities = 94/310 (30%), Positives = 149/310 (48%), Gaps = 14/310 (4%) Frame = +2 Query: 1874 KLDKAKLLVGHSFASGAHSRLYRGLYDDKPVAIKFIRR-PHEDPGGIMAAKLDKQYNTEI 2050 ++D A+L + G ++YR + VA+K R P ED ++ + E Sbjct: 131 EIDFAELTLEEIIGIGGFGKVYRAFWAGDEVAVKAARHDPDED-----ISQTIENVRQEA 185 Query: 2051 NALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIALEI 2230 + L H N+I L P ++ E GG L L + +P + ++ A++I Sbjct: 186 KLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSG---KRIPPDILVNWAVQI 242 Query: 2231 ARGLEYVHSQGVV---HRDIKPENILFDENFE--------VKIADFGIAXXXXXXXXXXX 2377 ARG+ Y+H + +V HRD+K NIL + E ++I DFG+A Sbjct: 243 ARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILEITDFGLAREWHRTTKMSA 302 Query: 2378 XXGTYRWMAPEMIKRKPYNRKVDVYSFGLLLWEMVTGRIPFENLSPVQVAYAVATDKLKP 2557 GTY WMAPE+I+ +++ DV+S+G+LLWE++TG +PF + + VAY VA +KL Sbjct: 303 A-GTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLAL 361 Query: 2558 MDPQDYCPAAVRPLIEQCCALQPEKRPDFWQLVKTLEKIQSVMSQGGSLDTLRSSGH--K 2731 P CP L+E C P RP F ++ L I+ + G + + S H + Sbjct: 362 PIPST-CPEPFAKLMEDCWNPDPHSRPSFTSILDQLTTIE----ESGFFEMPKDSFHCLQ 416 Query: 2732 KGLKHWIQKL 2761 KH IQ++ Sbjct: 417 DDWKHEIQEM 426
>Q05609:CTR1_ARATH Serine/threonine-protein kinase CTR1 - Arabidopsis thaliana| (Mouse-ear cress) Length = 821 Score = 134 bits (337), Expect = 2e-30 Identities = 84/273 (30%), Positives = 137/273 (50%), Gaps = 4/273 (1%) Frame = +2 Query: 1868 DWKLDKAKLLVGHSFASGAHSRLYRGLYDDKPVAIKFIRRPHEDPGGIMAAKLDKQYNTE 2047 D + L + +G+ ++R + VA+K + A+ ++ E Sbjct: 543 DMDIPWCDLNIKEKIGAGSFGTVHRAEWHGSDVAVKILMEQD------FHAERVNEFLRE 596 Query: 2048 INALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRP-LPLERTISIAL 2224 + + L H N++ + P I+TE L GSL LH R L R +S+A Sbjct: 597 VAIMKRLRHPNIVLFMGAVTQPPNLSIVTEYLSRGSLYRLLHKSGAREQLDERRRLSMAY 656 Query: 2225 EIARGLEYVHSQG--VVHRDIKPENILFDENFEVKIADFGIAXXXXXXXXXXXXX-GTYR 2395 ++A+G+ Y+H++ +VHRD+K N+L D+ + VK+ DFG++ GT Sbjct: 657 DVAKGMNYLHNRNPPIVHRDLKSPNLLVDKKYTVKVCDFGLSRLKASTFLSSKSAAGTPE 716 Query: 2396 WMAPEMIKRKPYNRKVDVYSFGLLLWEMVTGRIPFENLSPVQVAYAVATDKLKPMDPQDY 2575 WMAPE+++ +P N K DVYSFG++LWE+ T + P+ NL+P QV AV + P++ Sbjct: 717 WMAPEVLRDEPSNEKSDVYSFGVILWELATLQQPWGNLNPAQVVAAVGFKCKRLEIPRNL 776 Query: 2576 CPAAVRPLIEQCCALQPEKRPDFWQLVKTLEKI 2674 P V +IE C +P KRP F ++ L + Sbjct: 777 NP-QVAAIIEGCWTNEPWKRPSFATIMDLLRPL 808
>Q9NYL2:MLTK_HUMAN Mitogen-activated protein kinase kinase kinase MLT - Homo sapiens| (Human) Length = 800 Score = 134 bits (336), Expect = 3e-30 Identities = 81/259 (31%), Positives = 134/259 (51%), Gaps = 5/259 (1%) Frame = +2 Query: 1919 GAHSRLYRGLY--DDKPVAIKFIRRPHEDPGGIMAAKLDKQYNTEINALSHLYHKNVIKL 2092 G+ +YR + DK VA+K + K++K E LS L H+N+I+ Sbjct: 25 GSFGSVYRAKWISQDKEVAVKKL------------LKIEK----EAEILSVLSHRNIIQF 68 Query: 2093 VATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIALEIARGLEYVHSQG--- 2263 P Y I+TE GSL Y+++ + ++ ++ A ++A+G+ Y+H + Sbjct: 69 YGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAPVK 128 Query: 2264 VVHRDIKPENILFDENFEVKIADFGIAXXXXXXXXXXXXXGTYRWMAPEMIKRKPYNRKV 2443 V+HRD+K N++ + +KI DFG A GT+ WMAPE+I+ P + Sbjct: 129 VIHRDLKSRNVVIAADGVLKICDFG-ASRFHNHTTHMSLVGTFPWMAPEVIQSLPVSETC 187 Query: 2444 DVYSFGLLLWEMVTGRIPFENLSPVQVAYAVATDKLKPMDPQDYCPAAVRPLIEQCCALQ 2623 D YS+G++LWEM+T +PF+ L +QVA+ V +K + + CP + L+ QC Sbjct: 188 DTYSYGVVLWEMLTREVPFKGLEGLQVAWLV-VEKNERLTIPSSCPRSFAELLHQCWEAD 246 Query: 2624 PEKRPDFWQLVKTLEKIQS 2680 +KRP F Q++ LE + + Sbjct: 247 AKKRPSFKQIISILESMSN 265
>Q1HKZ5:M3K13_MOUSE Mitogen-activated protein kinase kinase kinase 13 - Mus musculus| (Mouse) Length = 959 Score = 132 bits (331), Expect = 1e-29 Identities = 83/286 (29%), Positives = 133/286 (46%) Frame = +2 Query: 1811 VENVRSRTVSMAQAVQSTVDWKLDKAKLLVGHSFASGAHSRLYRGLYDDKPVAIKFIRRP 1990 V N+ + S +Q W++ ++ SGA ++ G + + VAIK +R Sbjct: 140 VWNIIGKAYSTDYKLQQQDTWEVPFEEISELQWLGSGAQGAVFLGKFRAEEVAIKKVREQ 199 Query: 1991 HEDPGGIMAAKLDKQYNTEINALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYL 2170 +E T+I L L H N+I P Y II E G L L Sbjct: 200 NE---------------TDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVL 244 Query: 2171 HNPEHRPLPLERTISIALEIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIAXX 2350 R + + + IA G+ Y+H ++HRD+K N+L VKI+DFG + Sbjct: 245 R--AGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKE 302 Query: 2351 XXXXXXXXXXXGTYRWMAPEMIKRKPYNRKVDVYSFGLLLWEMVTGRIPFENLSPVQVAY 2530 GT WMAPE+I+ +P + KVD++SFG++LWE++TG IP++++ + + Sbjct: 303 LSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIW 362 Query: 2531 AVATDKLKPMDPQDYCPAAVRPLIEQCCALQPEKRPDFWQLVKTLE 2668 V ++ L P CP + L++Q +P RP F Q + L+ Sbjct: 363 GVGSNSLHLPVPST-CPDGFKILMKQTWQSKPRNRPSFRQTLMHLD 407
>O43283:M3K13_HUMAN Mitogen-activated protein kinase kinase kinase 13 - Homo sapiens| (Human) Length = 966 Score = 132 bits (331), Expect = 1e-29 Identities = 83/286 (29%), Positives = 133/286 (46%) Frame = +2 Query: 1811 VENVRSRTVSMAQAVQSTVDWKLDKAKLLVGHSFASGAHSRLYRGLYDDKPVAIKFIRRP 1990 V N+ + S +Q W++ ++ SGA ++ G + + VAIK +R Sbjct: 141 VWNIIGKAYSTDYKLQQQDTWEVPFEEISELQWLGSGAQGAVFLGKFRAEEVAIKKVREQ 200 Query: 1991 HEDPGGIMAAKLDKQYNTEINALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYL 2170 +E T+I L L H N+I P Y II E G L L Sbjct: 201 NE---------------TDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVL 245 Query: 2171 HNPEHRPLPLERTISIALEIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIAXX 2350 R + + + IA G+ Y+H ++HRD+K N+L VKI+DFG + Sbjct: 246 R--AGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKE 303 Query: 2351 XXXXXXXXXXXGTYRWMAPEMIKRKPYNRKVDVYSFGLLLWEMVTGRIPFENLSPVQVAY 2530 GT WMAPE+I+ +P + KVD++SFG++LWE++TG IP++++ + + Sbjct: 304 LSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIW 363 Query: 2531 AVATDKLKPMDPQDYCPAAVRPLIEQCCALQPEKRPDFWQLVKTLE 2668 V ++ L P CP + L++Q +P RP F Q + L+ Sbjct: 364 GVGSNSLHLPVPST-CPDGFKILMKQTWQSKPRNRPSFRQTLMHLD 408
>P18161:KYK2_DICDI Tyrosine-protein kinase 2 - Dictyostelium discoideum (Slime mold)| Length = 410 Score = 130 bits (328), Expect = 2e-29 Identities = 88/301 (29%), Positives = 148/301 (49%), Gaps = 8/301 (2%) Frame = +2 Query: 1796 RRVSAVENVRSRTVSMAQAVQSTVDWKLDKAKLLVGHSFASGAHSRLYRGLYDDKPVAIK 1975 +R E ++ +++ ++ +D + GA S ++ G + VAIK Sbjct: 76 QRAIESEKIKKTKFEELKSILGEREYIIDINDIQFIQKVGEGAFSEVWEGWWKGIHVAIK 135 Query: 1976 FIRRPHEDPGGIMAAKLDKQYNTEINALSHLYHKNVIKLVATHKCGPVYYIITELLPGGS 2155 ++ ++ + +++ E+ L H+N++ + C IITE + GGS Sbjct: 136 KLKIIGDEE------QFKERFIREVQNLKKGNHQNIVMFIGA--CYKPACIITEYMAGGS 187 Query: 2156 LRSYLHNPEHRPLPLERT----ISIALEIARGLEYVHSQGVVHRDIKPENILFDENFEVK 2323 L + LHNP ++ + + +A ++A GL ++HS +VHRD+ +NIL DE +K Sbjct: 188 LYNILHNPNSSTPKVKYSFPLVLKMATDMALGLLHLHSITIVHRDLTSQNILLDELGNIK 247 Query: 2324 IADFGIAXXXXXXXXXXXXXGTY---RWMAPEMIKRKP-YNRKVDVYSFGLLLWEMVTGR 2491 I+DFG++ G RW PE+ K Y+ KVDVY F L++WE++TG Sbjct: 248 ISDFGLSAEKSREGSMTMTNGGICNPRWRPPELTKNLGHYSEKVDVYCFSLVVWEILTGE 307 Query: 2492 IPFENLSPVQVAYAVATDKLKPMDPQDYCPAAVRPLIEQCCALQPEKRPDFWQLVKTLEK 2671 IPF +L Q + VA L+P P +YC ++ L+ QC P RP F +V L++ Sbjct: 308 IPFSDLDGSQRSAQVAYAGLRPPIP-EYCDPELKLLLTQCWEADPNDRPPFTYIVNKLKE 366 Query: 2672 I 2674 I Sbjct: 367 I 367
>P11346:KRAF1_DROME Raf homolog serine/threonine-protein kinase dRAF-1 - Drosophila| melanogaster (Fruit fly) Length = 739 Score = 130 bits (328), Expect = 2e-29 Identities = 110/416 (26%), Positives = 189/416 (45%), Gaps = 20/416 (4%) Frame = +2 Query: 1487 YPNQGSSVQNADGSLHKPR-------SKSPLPSVVPSDTFREAR----ASSQRFTSPPPK 1633 +P +G++V+ S + R S S P S R+ R + R S P Sbjct: 291 FPGRGTAVRFNMSSRSRSRRCSSSGSSSSSKPPSSSSGNHRQGRPPRISQDDRSNSAPNV 350 Query: 1634 RVGSDKSVYGKSLGREQCDMAASPDWCSTPVVFGEHSSQKDSSWTRRYFDNVGRRRVSAV 1813 + + +SV + + M A P P +HS+ +S T N R R + Sbjct: 351 CINNIRSVTSEV--QRSLIMQARPP---LPHPCTDHSNSTQASPTSTLKHNRPRARSADE 405 Query: 1814 ENVRSRTVSMAQAVQSTVDWKLDKAKLLVGHSFASGAHSRLYRGLYDDKPVAIKFIRRPH 1993 N + + + A S +W + ++L+G SG+ +YR + PVA+K + Sbjct: 406 SN---KNLLLRDAKSSEENWNILAEEILIGPRIGSGSFGTVYRAHWHG-PVAVKTLNVKT 461 Query: 1994 EDPGGIMAAKLDKQYNTEINALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLH 2173 P + A K E+ L H N++ + P I+T+ G SL ++H Sbjct: 462 PSPAQLQAFK------NEVAMLKKTRHCNILLFMGCVS-KPSLAIVTQWCEGSSLYKHVH 514 Query: 2174 NPEHRPLPLERTISIALEIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIA--- 2344 E + L I I ++A+G++Y+H++ ++HRD+K NI E+ VKI DFG+A Sbjct: 515 VSETK-FKLNTLIDIGRQVAQGMDYLHAKNIIHRDLKSNNIFLHEDLSVKIGDFGLATAK 573 Query: 2345 XXXXXXXXXXXXXGTYRWMAPEMIKRK---PYNRKVDVYSFGLLLWEMVTGRIPFENLS- 2512 G+ WMAPE+I+ + PY+ + DVY+FG++++E++ +P+ ++S Sbjct: 574 TRWSGEKQANQPTGSILWMAPEVIRMQELNPYSFQSDVYAFGIVMYELLAECLPYGHISN 633 Query: 2513 PVQVAYAVATDKLKP--MDPQDYCPAAVRPLIEQCCALQPEKRPDFWQLVKTLEKI 2674 Q+ + V L+P + P A++ L E C P+ RP F L+ LE + Sbjct: 634 KDQILFMVGRGLLRPDMSQVRSDAPQALKRLAEDCIKYTPKDRPLFRPLLNMLENM 689
>Q9H3Y6:SRMS_HUMAN Tyrosine-protein kinase Srms - Homo sapiens (Human)| Length = 488 Score = 130 bits (326), Expect = 4e-29 Identities = 86/272 (31%), Positives = 133/272 (48%), Gaps = 4/272 (1%) Frame = +2 Query: 1871 WKLDKAKLLVGHSFASGAHSRLYRGLY-DDKPVAIKFIRRPHEDPGGIMAAKLDKQYNTE 2047 W+ ++ +G G ++ GL+ PVAIK I+ + + L K E Sbjct: 223 WERPHSEFALGRKLGEGYFGEVWEGLWLGSLPVAIKVIKSAN-----MKLTDLAK----E 273 Query: 2048 INALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIALE 2227 I L L H+ +I+L A G YI+TEL+ G+L+++L PE R L L + A + Sbjct: 274 IQTLKGLRHERLIRLHAVCSGGEPVYIVTELMRKGNLQAFLGTPEGRALRLPPLLGFACQ 333 Query: 2228 IARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIAXXXXXXXXXXXXXG--TYRWM 2401 +A G+ Y+ Q VVHRD+ N+L D+ K+ADFG+A +W Sbjct: 334 VAEGMSYLEEQRVVHRDLAARNVLVDDGLACKVADFGLARLLKDDIYSPSSSSKIPVKWT 393 Query: 2402 APEMIKRKPYNRKVDVYSFGLLLWEMVT-GRIPFENLSPVQVAYAVATDKLKPMDPQDYC 2578 APE + +++K DV+SFG+LL E+ T G+ P+E ++ + + P C Sbjct: 394 APEAANYRVFSQKSDVWSFGVLLHEVFTYGQCPYEGMTNHETLQQIMRGYRLPRPAA--C 451 Query: 2579 PAAVRPLIEQCCALQPEKRPDFWQLVKTLEKI 2674 PA V L+ +C PE+RP F L + L I Sbjct: 452 PAEVYVLMLECWRSSPEERPSFATLREKLHAI 483
>Q62662:FRK_RAT Tyrosine-protein kinase FRK - Rattus norvegicus (Rat)| Length = 506 Score = 130 bits (326), Expect = 4e-29 Identities = 82/277 (29%), Positives = 139/277 (50%), Gaps = 8/277 (2%) Frame = +2 Query: 1862 TVD-WKLDKAKLLVGHSFASGAHSRLYRGLYDDK-PVAIKFIRRPHEDPGGIMAAKLDKQ 2035 TVD W++D+ + + SG ++ GL+++ PVA+K ++ DP + Sbjct: 224 TVDQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLR------ 277 Query: 2036 YNTEINALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTIS 2215 E + L H +I+L A YIITEL+ GSL+ YL N + L + + Sbjct: 278 ---EAQIMKSLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDGGSKIRLTQQVD 334 Query: 2216 IALEIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIAXXXXXXXXXXXXXG--- 2386 +A ++A G+ Y+ SQ +HRD+ N+L E+ K+ADFG+A Sbjct: 335 MAAQVASGMAYLESQNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESKHEI 394 Query: 2387 --TYRWMAPEMIKRKPYNRKVDVYSFGLLLWEMVT-GRIPFENLSPVQVAYAVATDKLKP 2557 +W APE I+ ++ K DV+SFG+LL+E++T G++P+ ++ QV + + + P Sbjct: 395 KLPVKWTAPEAIRTNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIHMLGQNYRLP 454 Query: 2558 MDPQDYCPAAVRPLIEQCCALQPEKRPDFWQLVKTLE 2668 CP ++ +C ++P++RP F L LE Sbjct: 455 QPSN--CPEQFYSIMMECWNVEPKQRPTFETLHWKLE 489
>Q5R8X7:M3K13_PONPY Mitogen-activated protein kinase kinase kinase 13 - Pongo pygmaeus| (Orangutan) Length = 966 Score = 129 bits (325), Expect = 6e-29 Identities = 81/286 (28%), Positives = 133/286 (46%) Frame = +2 Query: 1811 VENVRSRTVSMAQAVQSTVDWKLDKAKLLVGHSFASGAHSRLYRGLYDDKPVAIKFIRRP 1990 V N+ + + +Q W++ ++ SGA ++ G + + VAIK +R Sbjct: 141 VWNIIGKAYATDYKLQQQDTWEVPFEEISELQWLGSGAQGAVFLGKFRAEEVAIKKVREQ 200 Query: 1991 HEDPGGIMAAKLDKQYNTEINALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYL 2170 +E T+I L L H N+I P Y II E G L L Sbjct: 201 NE---------------TDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVL 245 Query: 2171 HNPEHRPLPLERTISIALEIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIAXX 2350 R + + + IA G+ Y+H ++HRD+K N+L VKI+DFG + Sbjct: 246 R--AGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKE 303 Query: 2351 XXXXXXXXXXXGTYRWMAPEMIKRKPYNRKVDVYSFGLLLWEMVTGRIPFENLSPVQVAY 2530 GT W+APE+I+ +P + KVD++SFG++LWE++TG IP++++ + + Sbjct: 304 LSDKSTKMSFAGTVAWLAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIW 363 Query: 2531 AVATDKLKPMDPQDYCPAAVRPLIEQCCALQPEKRPDFWQLVKTLE 2668 V ++ L P CP + L++Q +P RP F Q + L+ Sbjct: 364 GVGSNSLHLPVPST-CPDGFKILMKQTWQSKPRNRPSFRQTLMHLD 408
>P42685:FRK_HUMAN Tyrosine-protein kinase FRK - Homo sapiens (Human)| Length = 505 Score = 128 bits (322), Expect = 1e-28 Identities = 82/277 (29%), Positives = 139/277 (50%), Gaps = 8/277 (2%) Frame = +2 Query: 1862 TVD-WKLDKAKLLVGHSFASGAHSRLYRGLYDDK-PVAIKFIRRPHEDPGGIMAAKLDKQ 2035 TVD W++D+ + + SG ++ GL+++ PVA+K ++ DP + Sbjct: 223 TVDQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLR------ 276 Query: 2036 YNTEINALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTIS 2215 E + +L H +I+L A YIITEL+ GSL+ YL N + L + + Sbjct: 277 ---EAQIMKNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVD 333 Query: 2216 IALEIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIAXXXXXXXXXXXXXG--- 2386 +A ++A G+ Y+ S+ +HRD+ N+L E+ K+ADFG+A Sbjct: 334 MAAQVASGMAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEI 393 Query: 2387 --TYRWMAPEMIKRKPYNRKVDVYSFGLLLWEMVT-GRIPFENLSPVQVAYAVATDKLKP 2557 +W APE I+ ++ K DV+SFG+LL+E++T G++P+ ++ QV +A + P Sbjct: 394 KLPVKWTAPEAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLP 453 Query: 2558 MDPQDYCPAAVRPLIEQCCALQPEKRPDFWQLVKTLE 2668 CP ++ +C +P++RP F L LE Sbjct: 454 QPSN--CPQQFYNIMLECWNAEPKERPTFETLRWKLE 488
>Q62270:SRMS_MOUSE Tyrosine-protein kinase Srms - Mus musculus (Mouse)| Length = 496 Score = 128 bits (321), Expect = 2e-28 Identities = 84/280 (30%), Positives = 139/280 (49%), Gaps = 4/280 (1%) Frame = +2 Query: 1868 DWKLDKAKLLVGHSFASGAHSRLYRGLY-DDKPVAIKFIRRPHEDPGGIMAAKLDKQYNT 2044 +W+ +++ ++ G ++ GL+ PVA+K I+ + A L K Sbjct: 226 EWERPRSEFVLRRKLGEGFFGEVWEGLWLGSIPVAVKVIKS-----ADMKLADLTK---- 276 Query: 2045 EINALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIAL 2224 EI AL L H+ +I+L A G YI+TEL+ G+L+ YL + E + L L + A Sbjct: 277 EIEALKSLRHERLIRLHAICSLGEPVYIVTELMGKGNLQVYLGSSEGKALSLPHLLGFAC 336 Query: 2225 EIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIAXXXXXXXXXXXXXG--TYRW 2398 ++A G+ Y+ + VVHRD+ N+L ++ K+ADFG+A +W Sbjct: 337 QVAEGMSYLEERRVVHRDLAARNVLVGDDLTCKVADFGLARLLKDDVYSPSSGSKIPVKW 396 Query: 2399 MAPEMIKRKPYNRKVDVYSFGLLLWEMVT-GRIPFENLSPVQVAYAVATDKLKPMDPQDY 2575 APE + +++K DV+SFG+LL+E+ T G+ P+E ++ + ++ P Sbjct: 397 TAPEAANYRVFSQKSDVWSFGILLYEVFTYGQCPYEGMTNHETLQQISRGYRLPRPA--V 454 Query: 2576 CPAAVRPLIEQCCALQPEKRPDFWQLVKTLEKIQSVMSQG 2695 CPA V L+ +C PE+RP F L + L I + G Sbjct: 455 CPAEVYVLMVECWKGSPEERPTFAILREKLNAINRRLHLG 494
>P41243:MATK_RAT Megakaryocyte-associated tyrosine-protein kinase - Rattus norvegicus| (Rat) Length = 467 Score = 128 bits (321), Expect = 2e-28 Identities = 83/286 (29%), Positives = 141/286 (49%), Gaps = 1/286 (0%) Frame = +2 Query: 1811 VENVRSRTVSMAQAVQSTVDWKLDKAKLLVGHSFASGAHSRLYRGLYDDKPVAIKFIRRP 1990 V+ R + A+ + W LD L +G G + +G Y + VA+K I+ Sbjct: 167 VKPKRKQGAKSAEEELAKAGWLLDLQHLTLGAQIGEGEFGAVLQGEYLGQKVAVKNIK-- 224 Query: 1991 HEDPGGIMAAKLDKQYNTEINALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYL 2170 + + E ++ L H+N+++L+ +Y I+ E + G+L ++L Sbjct: 225 --------CDVTAQAFLDETAVMTKLQHRNLVRLLGVILHHGLY-IVMEHVSKGNLVNFL 275 Query: 2171 HNPEHRPLPLERTISIALEIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIAXX 2350 + + + AL +A G+EY+ S+ +VHRD+ NIL E+ K++DFG+A Sbjct: 276 RTRGRALVSTSQLLQFALHVAEGMEYLESKKLVHRDLAARNILVSEDLVAKVSDFGLAKA 335 Query: 2351 XXXXXXXXXXXGTYRWMAPEMIKRKPYNRKVDVYSFGLLLWEMVT-GRIPFENLSPVQVA 2527 +W APE +K ++ K DV+SFG+LLWE+ + GR P+ +S +V+ Sbjct: 336 ELRKGLDSSRL-PVKWTAPEALKNGRFSSKSDVWSFGVLLWEVFSYGRAPYPKMSLKEVS 394 Query: 2528 YAVATDKLKPMDPQDYCPAAVRPLIEQCCALQPEKRPDFWQLVKTL 2665 AV +K M+P D CP V L+ C +P +RP F ++V+ L Sbjct: 395 EAV--EKGYRMEPPDSCPGPVHTLMGSCWEAEPSRRPPFRKIVEKL 438
>P41242:MATK_MOUSE Megakaryocyte-associated tyrosine-protein kinase - Mus musculus| (Mouse) Length = 505 Score = 128 bits (321), Expect = 2e-28 Identities = 85/298 (28%), Positives = 145/298 (48%), Gaps = 1/298 (0%) Frame = +2 Query: 1775 YFDNVGRRRVSAVENVRSRTVSMAQAVQSTVDWKLDKAKLLVGHSFASGAHSRLYRGLYD 1954 Y + G V+ R + A+ + W LD L +G G + +G Y Sbjct: 194 YTKDKGAICTKLVKPRRKQGAKSAEEELAKAGWLLDLQHLTLGAQIGEGEFGAVLQGEYL 253 Query: 1955 DKPVAIKFIRRPHEDPGGIMAAKLDKQYNTEINALSHLYHKNVIKLVATHKCGPVYYIIT 2134 + VA+K I+ + + E ++ L H+N+++L+ +Y I+ Sbjct: 254 GQKVAVKNIK----------CDVTAQAFLDETAVMTKLQHRNLVRLLGVILHHGLY-IVM 302 Query: 2135 ELLPGGSLRSYLHNPEHRPLPLERTISIALEIARGLEYVHSQGVVHRDIKPENILFDENF 2314 E + G+L ++L + + + AL +A G+EY+ S+ +VHRD+ NIL E+ Sbjct: 303 EHVSKGNLVNFLRTRGRALVSTSQLLQFALHVAEGMEYLESKKLVHRDLAARNILVSEDL 362 Query: 2315 EVKIADFGIAXXXXXXXXXXXXXGTYRWMAPEMIKRKPYNRKVDVYSFGLLLWEMVT-GR 2491 K++DFG+A +W APE +K ++ K DV+SFG+LLWE+ + GR Sbjct: 363 VAKVSDFGLAKAERKGLDSSRL--PVKWTAPEALKNGRFSSKSDVWSFGVLLWEVFSYGR 420 Query: 2492 IPFENLSPVQVAYAVATDKLKPMDPQDYCPAAVRPLIEQCCALQPEKRPDFWQLVKTL 2665 P+ +S +V+ AV +K M+P D CP +V L+ C +P +RP F ++V+ L Sbjct: 421 APYPKMSLKEVSEAV--EKGYRMEPPDGCPGSVHTLMGSCWEAEPARRPPFRKIVEKL 476
>Q5TCX8:M3KL4_HUMAN Mitogen-activated protein kinase kinase kinase - Homo sapiens (Human)| Length = 1036 Score = 128 bits (321), Expect = 2e-28 Identities = 85/281 (30%), Positives = 136/281 (48%), Gaps = 24/281 (8%) Frame = +2 Query: 1916 SGAHSRLYRGLYDDKPVAIKFIRR-PHEDPGGIMAAKLDKQYNTEINALSHLYHKNVIKL 2092 +G ++YR + + VA+K R+ P +D AA + E + L H N+I+L Sbjct: 132 AGGFGQVYRATWQGQEVAVKAARQDPEQD-----AAAAAESVRREARLFAMLRHPNIIEL 186 Query: 2093 VATHKCGPVYYIITELLPGGSLRSYLHNPEHRP------------LPLERTISIALEIAR 2236 P ++ E GG+L L P +P ++ A++IAR Sbjct: 187 RGVCLQQPHLCLVLEFARGGALNRALAAANAAPDPRAPGPRRARRIPPHVLVNWAVQIAR 246 Query: 2237 GLEYVHSQG---VVHRDIKPENILFDENFE--------VKIADFGIAXXXXXXXXXXXXX 2383 G+ Y+H + ++HRD+K NIL E E +KI DFG+A Sbjct: 247 GMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRTTKMSTA- 305 Query: 2384 GTYRWMAPEMIKRKPYNRKVDVYSFGLLLWEMVTGRIPFENLSPVQVAYAVATDKLKPMD 2563 GTY WMAPE+IK +++ D++S+G+LLWE++TG +P+ + + VAY VA +KL Sbjct: 306 GTYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGVAVNKLTLPI 365 Query: 2564 PQDYCPAAVRPLIEQCCALQPEKRPDFWQLVKTLEKIQSVM 2686 P CP L+++C P RP F +++ L I+ + Sbjct: 366 PST-CPEPFAKLMKECWQQDPHIRPSFALILEQLTAIEGAV 405
>Q5UQG7:YR818_MIMIV Putative serine/threonine-protein kinase/receptor R818 precursor -| Mimivirus Length = 1651 Score = 127 bits (320), Expect = 2e-28 Identities = 81/268 (30%), Positives = 140/268 (52%), Gaps = 3/268 (1%) Frame = +2 Query: 1871 WKLDKAKLLVGHSFASGAHSRLYRGLYDDKPVAIK-FIRRPHEDPGGIMAAKLDKQYNTE 2047 W ++ + +G G++ + G + + VA+K F+++ ++ K ++ E Sbjct: 1387 WIINYDDIQIGKQIGVGSYGIVNMGKWKNINVAVKKFVKQKIDE-------KQMLEFRAE 1439 Query: 2048 INALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIALE 2227 I LS L H ++I ++ P I+TE + GSLR+ + + + I + + Sbjct: 1440 IAFLSQLRHPHIILMIGACLKRPNICIVTEFMGNGSLRNVIKTTKPE---WKLKIKMLYQ 1496 Query: 2228 IARGLEYVHSQG--VVHRDIKPENILFDENFEVKIADFGIAXXXXXXXXXXXXXGTYRWM 2401 A G+ Y+H+ ++HRDIKP NIL D++ VKIADFG A GT W Sbjct: 1497 TALGIGYLHNSDPIIIHRDIKPSNILVDDSMNVKIADFGFARIKEENSVMTRC-GTPCWT 1555 Query: 2402 APEMIKRKPYNRKVDVYSFGLLLWEMVTGRIPFENLSPVQVAYAVATDKLKPMDPQDYCP 2581 APE+I+ + Y KVDV+SFG+++WE++T + PF + ++V+ + + +P P D CP Sbjct: 1556 APEIIRGEKYTEKVDVFSFGIVMWEVLTCKEPFSGCNFMKVSMDI-LEGARPQIPSD-CP 1613 Query: 2582 AAVRPLIEQCCALQPEKRPDFWQLVKTL 2665 L++QC +P+KRP ++ L Sbjct: 1614 IDFTKLMKQCWHAKPDKRPSMEDVIMGL 1641 Score = 117 bits (293), Expect = 3e-25 Identities = 69/236 (29%), Positives = 118/236 (50%), Gaps = 6/236 (2%) Frame = +2 Query: 1868 DWKLDKAKLLVGHSFASGAHSRLYRGLYDDKPVAIKFIRRPHEDPGGIMAAKLDKQYNTE 2047 +W++D +L S SG +++ ++ VA+K + + + ++ + E Sbjct: 785 EWEVDFHELDFMESLGSGGSGEVFKAMWKGTEVAVKKLVNSN------ITKDAERNFKQE 838 Query: 2048 INALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIALE 2227 I+ ++ L H NV+ +A P I+ E + GSL L N +P I IA + Sbjct: 839 IHRMTSLRHPNVVLFMAASTRPPNMCIVMEFMSLGSLYDLLGNELVTEIPPVLRIRIAYQ 898 Query: 2228 IARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIAXXXXXXXXXXXXXG----TYR 2395 A+G+ ++HS +VHRD+K N+L D + VK++DFG+ + + Sbjct: 899 AAKGMHFLHSSDIVHRDLKSLNLLLDSKWNVKVSDFGLTKIKDNNKGKSSTKEDSVCSIQ 958 Query: 2396 WMAPEMIKRKPYNRKV--DVYSFGLLLWEMVTGRIPFENLSPVQVAYAVATDKLKP 2557 W APE++ K + DVYSFG+++WE++T P+ LSP +A AV D L+P Sbjct: 959 WTAPEVLSEKQDIDYILADVYSFGIIMWELMTRLRPYIGLSPAAIAVAVIRDNLRP 1014
>P42683:LCK_CHICK Proto-oncogene tyrosine-protein kinase LCK - Gallus gallus (Chicken)| Length = 508 Score = 127 bits (320), Expect = 2e-28 Identities = 83/271 (30%), Positives = 135/271 (49%), Gaps = 4/271 (1%) Frame = +2 Query: 1868 DWKLDKAKLLVGHSFASGAHSRLYRGLYDDKP-VAIKFIRRPHEDPGGIMAAKLDKQYNT 2044 +W++ + L + +G ++ G Y+ VAIK +++ P +A Sbjct: 236 EWEVPRESLKLVEKLGAGQFGEVWMGFYNGHTKVAIKNLKQGSMSPSAFLA--------- 286 Query: 2045 EINALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIAL 2224 E N + +L H +++L A P+Y IITE + GSL +L E L + + + +A Sbjct: 287 EANLMKNLQHPRLVRLYAVVTKEPIY-IITEYMEKGSLVDFLKTSEGIKLSINKLLDMAA 345 Query: 2225 EIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIAXXXXXXXXXXXXXGTY--RW 2398 +IA G+ ++ ++ +HRD++ NIL E KIADFG+A + +W Sbjct: 346 QIAEGMAFIEAKNYIHRDLRAANILVSEALCCKIADFGLARLIEDNEYTAREGAKFPIKW 405 Query: 2399 MAPEMIKRKPYNRKVDVYSFGLLLWEMVT-GRIPFENLSPVQVAYAVATDKLKPMDPQDY 2575 APE I + K DV+SFG+LL E+VT GRIP+ ++ +V + ++ M D Sbjct: 406 TAPEAINYGTFTIKSDVWSFGILLTEIVTYGRIPYPGMTNPEVIQNL--ERGYRMPQPDN 463 Query: 2576 CPAAVRPLIEQCCALQPEKRPDFWQLVKTLE 2668 CP + L+ QC QPE+RP F + LE Sbjct: 464 CPQELYELMMQCWKEQPEERPTFEYMKSVLE 494
>Q64434:PTK6_MOUSE Tyrosine-protein kinase 6 - Mus musculus (Mouse)| Length = 451 Score = 127 bits (319), Expect = 3e-28 Identities = 80/272 (29%), Positives = 131/272 (48%), Gaps = 3/272 (1%) Frame = +2 Query: 1868 DWKLDKAKLLVGHSFASGAHSRLYRGLYDDKP-VAIKFIRRPHEDPGGIMAAKLDKQYNT 2044 DW+ + + + +G ++ L+ + VA+K I R + + Sbjct: 183 DWERPREEFTLCKKLGAGYFGEVFEALWKGQVHVAVKVISRDN--------LLHQHTFQA 234 Query: 2045 EINALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIAL 2224 EI A+ L HK+++ L A G YIITEL+P G+L L + + + LP+ + A Sbjct: 235 EIQAMKKLRHKHILSLYAVATAGDPVYIITELMPKGNLLQLLRDSDEKALPILELVDFAS 294 Query: 2225 EIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIAXXXXXXXXXXXXXGT-YRWM 2401 ++A G+ Y+ SQ +HRD+ N+L EN K+ DFG+A Y+W Sbjct: 295 QVAEGMCYLESQNYIHRDLAARNVLVTENNLCKVGDFGLARLVKEDIYLSHEHNVPYKWT 354 Query: 2402 APEMIKRKPYNRKVDVYSFGLLLWEMVT-GRIPFENLSPVQVAYAVATDKLKPMDPQDYC 2578 APE + R Y+ K DV+SFG+LL E+ + G++P+ +S + V P + C Sbjct: 355 APEALSRGHYSIKSDVWSFGVLLHEIFSRGQMPYPGMSNHETFLRVDAGYRMPCPLE--C 412 Query: 2579 PAAVRPLIEQCCALQPEKRPDFWQLVKTLEKI 2674 P + L+ C + P++RP F L + L I Sbjct: 413 PPNIHKLMLSCWSRDPKQRPCFKDLCEKLTGI 444
>Q01389:BCK1_YEAST Serine/threonine-protein kinase BCK1/SLK1/SSP31 - Saccharomyces| cerevisiae (Baker's yeast) Length = 1478 Score = 127 bits (319), Expect = 3e-28 Identities = 115/467 (24%), Positives = 200/467 (42%), Gaps = 11/467 (2%) Frame = +2 Query: 1271 NDKTVAALKHTASLPSLRSTLQPNEKKASKQKMSLEIPLSPPAKSEKSKAPRARSLVKSP 1450 +D + + K TA P + + +EK + S EI + + R + P Sbjct: 978 SDDIIWSKKKTA--PETNNENKKDEKSDNSSTHSDEIFYDSQTQDKME-----RKMTFRP 1030 Query: 1451 SSMMLLSYLNKAYPNQGSSVQNADGSLHKPRSKSPLPSVVPSDTFREARASSQRFTSPPP 1630 S ++ L K +P +G + P S L S++ +R + P P Sbjct: 1031 SPEVVYQNLEKFFPRANLDKPITEG-IASPTSPKSLDSLLSPKNVASSRTEPSTPSRPVP 1089 Query: 1631 KRVGSDKSVYGKSLGREQCDMAASPDWCSTPVVFGEHSS--QKDSSWTRRYFDNV-GRRR 1801 + G + + + A +P T +S +K+S +R + G R Sbjct: 1090 PDSSYEFIQDGLNGKNKPLNQAKTPKRTKTIRTIAHEASLARKNSVKLKRQNTKMWGTRM 1149 Query: 1802 VSAVENVRSRTVSMAQAVQSTVDWKLDKAKLLVGHSFASGAHSRLYRGLY--DDKPVAIK 1975 V EN VS+ +A S ++K + + G G+ +Y L + +A+K Sbjct: 1150 VEVTEN---HMVSINKAKNSKGEYK--EFAWMKGEMIGKGSFGAVYLCLNVTTGEMMAVK 1204 Query: 1976 FIRRPHEDPGGIMAAKLDKQYNTEINALSHLYHKNVIKLVATHKCGPVYYIITELLPGGS 2155 + P + +E++ L L H N+++ + +Y + E + GGS Sbjct: 1205 QVEVPKYSSQNEAILSTVEALRSEVSTLKDLDHLNIVQYLGFENKNNIYSLFLEYVAGGS 1264 Query: 2156 LRSYLHNPEHRPLPLERTISIALEIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADF 2335 + S + PL + ++ ++ +GL Y+HS+G++HRD+K +N+L D++ KI+DF Sbjct: 1265 VGSLIRMYGRFDEPLIKHLTT--QVLKGLAYLHSKGILHRDMKADNLLLDQDGICKISDF 1322 Query: 2336 GIA--XXXXXXXXXXXXXGTYRWMAPEMIKRKP-YNRKVDVYSFGLLLWEMVTGRIPFEN 2506 GI+ GT WMAPEM+ K Y+ KVD++S G ++ EM G+ P+ N Sbjct: 1323 GISRKSKDIYSNSDMTMRGTVFWMAPEMVDTKQGYSAKVDIWSLGCIVLEMFAGKRPWSN 1382 Query: 2507 LSPVQVAYAVATDKLKPMDPQDYCPAAV---RPLIEQCCALQPEKRP 2638 L V + + K P P+D P R ++ C + PEKRP Sbjct: 1383 LEVVAAMFKIGKSKSAPPIPEDTLPLISQIGRNFLDACFEINPEKRP 1429
>Q922K9:FRK_MOUSE Tyrosine-protein kinase FRK - Mus musculus (Mouse)| Length = 512 Score = 127 bits (318), Expect = 4e-28 Identities = 79/273 (28%), Positives = 136/273 (49%), Gaps = 7/273 (2%) Frame = +2 Query: 1871 WKLDKAKLLVGHSFASGAHSRLYRGLYDDK-PVAIKFIRRPHEDPGGIMAAKLDKQYNTE 2047 W++D+ + + SG ++ GL+++ PVA+K ++ DP + E Sbjct: 234 WEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLR---------E 284 Query: 2048 INALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIALE 2227 + L H +I+L A YIITEL+ GSL+ YL N + L + + +A + Sbjct: 285 AQIMKSLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDGGSKIHLIQQVDMAAQ 344 Query: 2228 IARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIAXXXXXXXXXXXXXG-----TY 2392 +A G+ Y+ SQ +HRD+ N+L E+ K+ADFG+A Sbjct: 345 VASGMAYLESQNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESKHEIKLPV 404 Query: 2393 RWMAPEMIKRKPYNRKVDVYSFGLLLWEMVT-GRIPFENLSPVQVAYAVATDKLKPMDPQ 2569 +W APE I+ ++ K DV+SFG+LL+E++T G++P+ ++ QV ++ + P Sbjct: 405 KWTAPEAIRTNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLSQNYRLPQPSN 464 Query: 2570 DYCPAAVRPLIEQCCALQPEKRPDFWQLVKTLE 2668 CP ++ +C ++P++RP F L LE Sbjct: 465 --CPQQFYSIMLECWNVEPKQRPTFETLHWKLE 495
>Q7TQP6:TNI3K_RAT Serine/threonine-protein kinase TNNI3K - Rattus norvegicus (Rat)| Length = 835 Score = 126 bits (316), Expect = 6e-28 Identities = 89/260 (34%), Positives = 136/260 (52%), Gaps = 8/260 (3%) Frame = +2 Query: 1916 SGAHSRLYRGLYDDKPVAIKFIRRPHEDPGGIMAAKLD-KQYNTEINALSHLYHKNVIKL 2092 SG+ ++Y+G +K VAIK R +K D + E++ L L H V++ Sbjct: 471 SGSFGKVYKGRCRNKIVAIKRYR------ANTYCSKSDVDMFCREVSILCQLNHPCVVQF 524 Query: 2093 VATHKCGPVYY-IITELLPGGSLRSYLHNPEHRPLPLERTISIALEIARGLEYVHS--QG 2263 V P + I+T+ + GGSL S LH + R L L+ + IA+++A+G+EY+HS Q Sbjct: 525 VGACLDDPSQFAIVTQYISGGSLFSLLHE-QKRILDLQSKLIIAVDVAKGMEYLHSLTQP 583 Query: 2264 VVHRDIKPENILFDENFEVKIADFGIAXXXXXXXXXXXXX--GTYRWMAPEMIKR-KPYN 2434 ++HRD+ NIL E+ +ADFG + G RWMAPE+ + Y Sbjct: 584 IIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNLRWMAPEVFTQCTRYT 643 Query: 2435 RKVDVYSFGLLLWEMVTGRIPFENLSPVQVAYAVATDKLKPMDPQDY-CPAAVRPLIEQC 2611 K DV+S+ L LWE++TG IPF +L P A +A ++P P Y P + L+ + Sbjct: 644 IKADVFSYSLCLWELLTGEIPFAHLKPAAAAADMAYHHIRP--PIGYSIPKPISSLLIRG 701 Query: 2612 CALQPEKRPDFWQLVKTLEK 2671 PE RP+F ++V LE+ Sbjct: 702 WNACPEGRPEFSEVVSKLEE 721
>Q9V9J3:SRC42_DROME Tyrosine-protein kinase Src42A - Drosophila melanogaster (Fruit fly)| Length = 517 Score = 125 bits (315), Expect = 8e-28 Identities = 87/272 (31%), Positives = 130/272 (47%), Gaps = 6/272 (2%) Frame = +2 Query: 1871 WKLDKAKLLVGHSFASGAHSRLYRGLYDDK-PVAIKFIRRPHEDPGGIMAAKLDKQYNTE 2047 W++D+ L SG ++ GL+++ PVAIK ++ DP K + E Sbjct: 241 WEIDRTSLKFVRKLGSGQFGDVWEGLWNNTTPVAIKTLKSGTMDP---------KDFLAE 291 Query: 2048 INALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHN--PEHRPLPLERTISIA 2221 + L H +I+L A YIITEL+ GSL YL + R L ++ I +A Sbjct: 292 AQIMKKLRHTKLIQLYAVCTVEEPIYIITELMKHGSLLEYLQAIAGKGRSLKMQTLIDMA 351 Query: 2222 LEIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIAXXXXXXXXXXXXXGTY--R 2395 +IA G+ Y+ SQ +HRD+ N+L + VKIADFG+A + + Sbjct: 352 AQIAAGMAYLESQNYIHRDLAARNVLVGDGNIVKIADFGLARLIKEDEYEARVGARFPIK 411 Query: 2396 WMAPEMIKRKPYNRKVDVYSFGLLLWEMVT-GRIPFENLSPVQVAYAVATDKLKPMDPQD 2572 W APE ++ K DV+SFG+LL E+VT GRIP+ ++ +V V P P Sbjct: 412 WTAPEAANYSKFSIKSDVWSFGILLTELVTYGRIPYPGMTNAEVLTQVEHGYRMPQPPN- 470 Query: 2573 YCPAAVRPLIEQCCALQPEKRPDFWQLVKTLE 2668 C + ++ +C P +RP F L LE Sbjct: 471 -CEPRLYEIMLECWHKDPMRRPTFETLQWKLE 501
>P11345:RAF1_RAT RAF proto-oncogene serine/threonine-protein kinase - Rattus| norvegicus (Rat) Length = 648 Score = 125 bits (314), Expect = 1e-27 Identities = 82/306 (26%), Positives = 157/306 (51%), Gaps = 12/306 (3%) Frame = +2 Query: 1859 STVDWKLDKAKLLVGHSFASGAHSRLYRGLYDDKPVAIKFIRRPHEDPGGIMAAKLDKQY 2038 S+ W+++ +++++ SG+ +Y+G + VA+K ++ P + A + Sbjct: 338 SSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGD-VAVKILKVVDPTPEQLQA------F 390 Query: 2039 NTEINALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISI 2218 E+ L H N++ L + I+T+ G SL +LH E + + + I I Sbjct: 391 RNEVAVLRKTRHVNIL-LFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETK-FQMFQLIDI 448 Query: 2219 ALEIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIA---XXXXXXXXXXXXXGT 2389 A + A+G++Y+H++ ++HRD+K NI E VKI DFG+A G+ Sbjct: 449 ARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGS 508 Query: 2390 YRWMAPEMIK---RKPYNRKVDVYSFGLLLWEMVTGRIPFENL-SPVQVAYAVATDKLKP 2557 WMAPE+I+ P++ + DVYS+G++L+E++TG +P+ ++ + Q+ + V P Sbjct: 509 VLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASP 568 Query: 2558 MDPQDY--CPAAVRPLIEQCCALQPEKRPDFWQLVKTLEKIQSVM---SQGGSLDTLRSS 2722 + Y CP A++ L+ C E+RP F Q++ ++E +Q + ++ S +L + Sbjct: 569 DLSRLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRA 628 Query: 2723 GHKKGL 2740 H + + Sbjct: 629 AHTEDI 634
>Q5PXS1:LCK_AOTNA Proto-oncogene tyrosine-protein kinase LCK - Aotus nancymaae (Ma's| night monkey) Length = 509 Score = 125 bits (314), Expect = 1e-27 Identities = 81/271 (29%), Positives = 133/271 (49%), Gaps = 4/271 (1%) Frame = +2 Query: 1868 DWKLDKAKLLVGHSFASGAHSRLYRGLYDDKP-VAIKFIRRPHEDPGGIMAAKLDKQYNT 2044 +W++ + L + +G ++ G Y+D VA+K +++ P +A Sbjct: 237 EWEVPRETLKLVERLGAGQFGEVWMGYYNDHTKVAVKSLKQGSMSPDAFLA--------- 287 Query: 2045 EINALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIAL 2224 E N + L H+ +++L A P+Y IITE + GSL +L P L + + + +A Sbjct: 288 EANLMKQLQHQRLVRLYAVVTQEPIY-IITEYMENGSLVDFLKTPSGIKLTINKLLDMAA 346 Query: 2225 EIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIAXXXXXXXXXXXXXGTY--RW 2398 +IA G+ ++ + +HRD++ NIL + KIADFG+A + +W Sbjct: 347 QIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKW 406 Query: 2399 MAPEMIKRKPYNRKVDVYSFGLLLWEMVT-GRIPFENLSPVQVAYAVATDKLKPMDPQDY 2575 APE I + K DV+SFG+LL E+VT GRIP+ ++ +V + ++ M D Sbjct: 407 TAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNL--ERGYRMVRPDN 464 Query: 2576 CPAAVRPLIEQCCALQPEKRPDFWQLVKTLE 2668 CP + L+ C +PE RP F L LE Sbjct: 465 CPEELYHLMMLCWKERPEDRPTFDYLRSVLE 495
>Q5GIG6:TNI3K_MOUSE Serine/threonine-protein kinase TNNI3K - Mus musculus (Mouse)| Length = 834 Score = 125 bits (313), Expect = 1e-27 Identities = 88/260 (33%), Positives = 136/260 (52%), Gaps = 8/260 (3%) Frame = +2 Query: 1916 SGAHSRLYRGLYDDKPVAIKFIRRPHEDPGGIMAAKLD-KQYNTEINALSHLYHKNVIKL 2092 SG+ ++Y+G +K VAIK R +K D + E++ L L H V++ Sbjct: 470 SGSFGKVYKGRCRNKIVAIKRYR------ANTYCSKSDVDMFCREVSILCQLNHPCVVQF 523 Query: 2093 VATHKCGPVYY-IITELLPGGSLRSYLHNPEHRPLPLERTISIALEIARGLEYVHS--QG 2263 V P + I+T+ + GGSL S LH + R L L+ + IA+++A+G+EY+HS Q Sbjct: 524 VGACLDDPSQFAIVTQYISGGSLFSLLHE-QKRILDLQSKLIIAVDVAKGMEYLHSLTQP 582 Query: 2264 VVHRDIKPENILFDENFEVKIADFGIAXXXXXXXXXXXXX--GTYRWMAPEMIKR-KPYN 2434 ++HRD+ NIL E+ +ADFG + G RWMAPE+ + Y Sbjct: 583 IIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNLRWMAPEVFTQCTRYT 642 Query: 2435 RKVDVYSFGLLLWEMVTGRIPFENLSPVQVAYAVATDKLKPMDPQDY-CPAAVRPLIEQC 2611 K DV+S+ L LWE++ G IPF +L P A +A ++P P Y P + L+ + Sbjct: 643 IKADVFSYALCLWELLIGEIPFAHLKPAAAAADMAYHHIRP--PIGYSIPKPISSLLMRG 700 Query: 2612 CALQPEKRPDFWQLVKTLEK 2671 PE RP+F ++V+ LE+ Sbjct: 701 WNACPEGRPEFSEVVRKLEE 720
>P00532:RAF_MSV36 Serine/threonine-protein kinase-transforming protein raf - Murine| sarcoma virus 3611 Length = 323 Score = 125 bits (313), Expect = 1e-27 Identities = 79/282 (28%), Positives = 147/282 (52%), Gaps = 9/282 (3%) Frame = +2 Query: 1859 STVDWKLDKAKLLVGHSFASGAHSRLYRGLYDDKPVAIKFIRRPHEDPGGIMAAKLDKQY 2038 S+ WK++ +++++ SG+ +Y+G + VA+K ++ P + A + Sbjct: 13 SSYYWKMEASEVMLSTRIGSGSFGTVYKGKWHGD-VAVKILKVVDPTPEQLQA------F 65 Query: 2039 NTEINALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISI 2218 E+ L H N++ L + I+T+ G SL +LH E + + + I I Sbjct: 66 RNEVAVLRKTRHVNIL-LFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETK-FQMFQLIDI 123 Query: 2219 ALEIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIA---XXXXXXXXXXXXXGT 2389 A + A+G++Y+H++ ++HRD+K NI E VKI DFG+A G+ Sbjct: 124 ARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGS 183 Query: 2390 YRWMAPEMIKRK---PYNRKVDVYSFGLLLWEMVTGRIPFENL-SPVQVAYAVATDKLKP 2557 WMAPE+I+ + P++ + DVYS+G++L+E++ G +P+ ++ + Q+ + V P Sbjct: 184 VLWMAPEVIRMQDDNPFSFQSDVYSYGIVLYELMAGELPYAHINNRDQIIFMVGRGYASP 243 Query: 2558 MDPQDY--CPAAVRPLIEQCCALQPEKRPDFWQLVKTLEKIQ 2677 + Y CP A++ L+ C E+RP F Q++ ++E +Q Sbjct: 244 DLSRLYKNCPKAIKRLVADCVKKVKEERPLFPQILSSIELLQ 285
>Q59H18:TNI3K_HUMAN Serine/threonine-protein kinase TNNI3K - Homo sapiens (Human)| Length = 936 Score = 124 bits (312), Expect = 2e-27 Identities = 89/260 (34%), Positives = 136/260 (52%), Gaps = 8/260 (3%) Frame = +2 Query: 1916 SGAHSRLYRGLYDDKPVAIKFIRRPHEDPGGIMAAKLD-KQYNTEINALSHLYHKNVIKL 2092 SG+ ++Y+G +K VAIK R +K D + E++ L L H VI+ Sbjct: 572 SGSFGKVYKGRCRNKIVAIKRYR------ANTYCSKSDVDMFCREVSILCQLNHPCVIQF 625 Query: 2093 VATHKCGPVYY-IITELLPGGSLRSYLHNPEHRPLPLERTISIALEIARGLEYVHS--QG 2263 V P + I+T+ + GGSL S LH + R L L+ + IA+++A+G+EY+H+ Q Sbjct: 626 VGACLNDPSQFAIVTQYISGGSLFSLLHE-QKRILDLQSKLIIAVDVAKGMEYLHNLTQP 684 Query: 2264 VVHRDIKPENILFDENFEVKIADFGIAXXXXXXXXXXXXX--GTYRWMAPEMIKR-KPYN 2434 ++HRD+ NIL E+ +ADFG + G RWMAPE+ + Y Sbjct: 685 IIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNLRWMAPEVFTQCTRYT 744 Query: 2435 RKVDVYSFGLLLWEMVTGRIPFENLSPVQVAYAVATDKLKPMDPQDY-CPAAVRPLIEQC 2611 K DV+S+ L LWE++TG IPF +L P A +A ++P P Y P + L+ + Sbjct: 745 IKADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYHHIRP--PIGYSIPKPISSLLIRG 802 Query: 2612 CALQPEKRPDFWQLVKTLEK 2671 PE RP+F ++V LE+ Sbjct: 803 WNACPEGRPEFSEVVMKLEE 822
>Q5R5M7:RAF1_PONPY RAF proto-oncogene serine/threonine-protein kinase - Pongo pygmaeus| (Orangutan) Length = 648 Score = 124 bits (312), Expect = 2e-27 Identities = 82/306 (26%), Positives = 156/306 (50%), Gaps = 12/306 (3%) Frame = +2 Query: 1859 STVDWKLDKAKLLVGHSFASGAHSRLYRGLYDDKPVAIKFIRRPHEDPGGIMAAKLDKQY 2038 S+ W+++ +++++ SG+ +Y+G + VA+K ++ P A + Sbjct: 338 SSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGD-VAVKILKVVDPTPEQFQA------F 390 Query: 2039 NTEINALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISI 2218 E+ L H N++ L + I+T+ G SL +LH E + + + I I Sbjct: 391 RNEVAVLRKTRHVNIL-LFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETK-FQMFQLIDI 448 Query: 2219 ALEIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIA---XXXXXXXXXXXXXGT 2389 A + A+G++Y+H++ ++HRD+K NI E VKI DFG+A G+ Sbjct: 449 ARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGS 508 Query: 2390 YRWMAPEMIK---RKPYNRKVDVYSFGLLLWEMVTGRIPFENL-SPVQVAYAVATDKLKP 2557 WMAPE+I+ P++ + DVYS+G++L+E++TG +P+ ++ + Q+ + V P Sbjct: 509 VLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASP 568 Query: 2558 MDPQDY--CPAAVRPLIEQCCALQPEKRPDFWQLVKTLEKIQSVM---SQGGSLDTLRSS 2722 + Y CP A++ L+ C E+RP F Q++ ++E +Q + ++ S +L + Sbjct: 569 DLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRA 628 Query: 2723 GHKKGL 2740 H + + Sbjct: 629 AHTEDI 634
>P04049:RAF1_HUMAN RAF proto-oncogene serine/threonine-protein kinase - Homo sapiens| (Human) Length = 648 Score = 124 bits (312), Expect = 2e-27 Identities = 82/306 (26%), Positives = 156/306 (50%), Gaps = 12/306 (3%) Frame = +2 Query: 1859 STVDWKLDKAKLLVGHSFASGAHSRLYRGLYDDKPVAIKFIRRPHEDPGGIMAAKLDKQY 2038 S+ W+++ +++++ SG+ +Y+G + VA+K ++ P A + Sbjct: 338 SSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGD-VAVKILKVVDPTPEQFQA------F 390 Query: 2039 NTEINALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISI 2218 E+ L H N++ L + I+T+ G SL +LH E + + + I I Sbjct: 391 RNEVAVLRKTRHVNIL-LFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETK-FQMFQLIDI 448 Query: 2219 ALEIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIA---XXXXXXXXXXXXXGT 2389 A + A+G++Y+H++ ++HRD+K NI E VKI DFG+A G+ Sbjct: 449 ARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGS 508 Query: 2390 YRWMAPEMIK---RKPYNRKVDVYSFGLLLWEMVTGRIPFENL-SPVQVAYAVATDKLKP 2557 WMAPE+I+ P++ + DVYS+G++L+E++TG +P+ ++ + Q+ + V P Sbjct: 509 VLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASP 568 Query: 2558 MDPQDY--CPAAVRPLIEQCCALQPEKRPDFWQLVKTLEKIQSVM---SQGGSLDTLRSS 2722 + Y CP A++ L+ C E+RP F Q++ ++E +Q + ++ S +L + Sbjct: 569 DLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRA 628 Query: 2723 GHKKGL 2740 H + + Sbjct: 629 AHTEDI 634
>Q95KR7:LCK_SAISC Proto-oncogene tyrosine-protein kinase LCK - Saimiri sciureus (Common| squirrel monkey) Length = 509 Score = 124 bits (312), Expect = 2e-27 Identities = 79/271 (29%), Positives = 133/271 (49%), Gaps = 4/271 (1%) Frame = +2 Query: 1868 DWKLDKAKLLVGHSFASGAHSRLYRGLYDDKP-VAIKFIRRPHEDPGGIMAAKLDKQYNT 2044 +W++ + L + +G ++ G Y++ VA+K +++ P +A Sbjct: 237 EWEVPRETLKLVERLGAGQFGEVWMGYYNEHTKVAVKSLKQGSMSPDAFLA--------- 287 Query: 2045 EINALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIAL 2224 E N + L HK +++L A P+Y IITE + GSL +L P L + + + +A Sbjct: 288 EANLMKQLQHKRLVRLYAVVTEEPIY-IITEYMENGSLVDFLKTPSGIKLTINKLLDMAA 346 Query: 2225 EIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIAXXXXXXXXXXXXXGTY--RW 2398 +I G+ ++ + +HRD++ NIL + KIADFG+A + +W Sbjct: 347 QIVEGMAFLEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKW 406 Query: 2399 MAPEMIKRKPYNRKVDVYSFGLLLWEMVT-GRIPFENLSPVQVAYAVATDKLKPMDPQDY 2575 APE I + K DV+SFG+L+ E+VT GRIP+ ++ +V + ++ M D Sbjct: 407 TAPEAINYGTFTIKSDVWSFGILMTEIVTHGRIPYPGMTNPEVIQNL--ERGYRMPRPDN 464 Query: 2576 CPAAVRPLIEQCCALQPEKRPDFWQLVKTLE 2668 CP + L+ QC +P+ RP F L LE Sbjct: 465 CPEELYKLMMQCWRERPDDRPTFDYLRSVLE 495
>P05625:RAF1_CHICK RAF proto-oncogene serine/threonine-protein kinase - Gallus gallus| (Chicken) Length = 647 Score = 124 bits (311), Expect = 2e-27 Identities = 82/306 (26%), Positives = 157/306 (51%), Gaps = 12/306 (3%) Frame = +2 Query: 1859 STVDWKLDKAKLLVGHSFASGAHSRLYRGLYDDKPVAIKFIRRPHEDPGGIMAAKLDKQY 2038 S+ W+++ +++++ SG+ +Y+G + VA+K ++ P A + Sbjct: 338 SSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGD-VAVKILKVVDPTPEQFQA------F 390 Query: 2039 NTEINALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISI 2218 E+ L H N++ L + I+T+ G SL +LH E + + + I I Sbjct: 391 RNEVAVLRKTRHVNIL-LFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETK-FQMFQLIDI 448 Query: 2219 ALEIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIA---XXXXXXXXXXXXXGT 2389 A + A+G++Y+H++ ++HRD+K NI E VKI DFG+A G+ Sbjct: 449 ARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGS 508 Query: 2390 YRWMAPEMIKRK---PYNRKVDVYSFGLLLWEMVTGRIPFENL-SPVQVAYAVATDKLKP 2557 WMAPE+I+ + P++ + DVYS+G++L+E++TG +P+ ++ + Q+ + V P Sbjct: 509 ILWMAPEVIRMQDSNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASP 568 Query: 2558 MDPQDY--CPAAVRPLIEQCCALQPEKRPDFWQLVKTLEKIQSVM---SQGGSLDTLRSS 2722 + Y CP A++ L+ C E+RP F Q++ ++E +Q + ++ S +L + Sbjct: 569 DLSKLYKNCPKAMKRLVADCLKKVREERPLFPQILSSIELLQHSLPKINRSASEPSLHRA 628 Query: 2723 GHKKGL 2740 H + + Sbjct: 629 SHTEDI 634
>O19004:ARAF_PIG A-Raf proto-oncogene serine/threonine-protein kinase - Sus scrofa| (Pig) Length = 606 Score = 124 bits (311), Expect = 2e-27 Identities = 80/278 (28%), Positives = 144/278 (51%), Gaps = 9/278 (3%) Frame = +2 Query: 1871 WKLDKAKLLVGHSFASGAHSRLYRGLYDDKPVAIKFIRRPHEDPGGIMAAKLDKQYNTEI 2050 W++ +++ + +G+ ++RG + VA+K ++ A+ + + E+ Sbjct: 303 WEVPPSEVQLLKRIGTGSFGTVFRGRWHGD-VAVKVLKVAQP------TAEQAQAFKNEM 355 Query: 2051 NALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIALEI 2230 L H N++ L P + IIT+ G SL +LH + R + + I +A + Sbjct: 356 QVLRKTRHVNIL-LFMGFMTRPGFAIITQWCEGSSLYHHLHVADTR-FDMVQLIDVARQT 413 Query: 2231 ARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIA---XXXXXXXXXXXXXGTYRWM 2401 A+G++Y+H++ ++HRD+K NI E VKI DFG+A G+ WM Sbjct: 414 AQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWM 473 Query: 2402 APEMIKRK---PYNRKVDVYSFGLLLWEMVTGRIPFENL-SPVQVAYAVATDKLKP--MD 2563 A E+I+ + PY+ + DVY++G++L+E++TG +P+ ++ S Q+ + V L P Sbjct: 474 AAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGSRDQIIFMVGRGYLSPDLSK 533 Query: 2564 PQDYCPAAVRPLIEQCCALQPEKRPDFWQLVKTLEKIQ 2677 CP A+R L+ C Q E+RP F Q++ T+E +Q Sbjct: 534 ISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQ 571
>P06239:LCK_HUMAN Proto-oncogene tyrosine-protein kinase LCK - Homo sapiens (Human)| Length = 509 Score = 124 bits (310), Expect = 3e-27 Identities = 80/271 (29%), Positives = 132/271 (48%), Gaps = 4/271 (1%) Frame = +2 Query: 1868 DWKLDKAKLLVGHSFASGAHSRLYRGLYDDKP-VAIKFIRRPHEDPGGIMAAKLDKQYNT 2044 +W++ + L + +G ++ G Y+ VA+K +++ P +A Sbjct: 237 EWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLA--------- 287 Query: 2045 EINALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIAL 2224 E N + L H+ +++L A P+Y IITE + GSL +L P L + + + +A Sbjct: 288 EANLMKQLQHQRLVRLYAVVTQEPIY-IITEYMENGSLVDFLKTPSGIKLTINKLLDMAA 346 Query: 2225 EIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIAXXXXXXXXXXXXXGTY--RW 2398 +IA G+ ++ + +HRD++ NIL + KIADFG+A + +W Sbjct: 347 QIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKW 406 Query: 2399 MAPEMIKRKPYNRKVDVYSFGLLLWEMVT-GRIPFENLSPVQVAYAVATDKLKPMDPQDY 2575 APE I + K DV+SFG+LL E+VT GRIP+ ++ +V + ++ M D Sbjct: 407 TAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNL--ERGYRMVRPDN 464 Query: 2576 CPAAVRPLIEQCCALQPEKRPDFWQLVKTLE 2668 CP + L+ C +PE RP F L LE Sbjct: 465 CPEELYQLMRLCWKERPEDRPTFDYLRSVLE 495
>P14056:ARAF_RAT A-Raf proto-oncogene serine/threonine-protein kinase - Rattus| norvegicus (Rat) Length = 604 Score = 124 bits (310), Expect = 3e-27 Identities = 80/278 (28%), Positives = 146/278 (52%), Gaps = 9/278 (3%) Frame = +2 Query: 1871 WKLDKAKLLVGHSFASGAHSRLYRGLYDDKPVAIKFIRRPHEDPGGIMAAKLDKQYNTEI 2050 W++ +++ + +G+ ++RG + VA+K ++ A+ + + E+ Sbjct: 301 WEVPPSEVQLLKRIGTGSFGTVFRGRWHGD-VAVKVLKVAQP------TAEQAQAFKNEM 353 Query: 2051 NALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIALEI 2230 L H N++ L P + IIT+ G SL +LH + R + + I +A + Sbjct: 354 QVLRKTRHVNIL-LFMGFMTRPGFAIITQWCEGSSLYHHLHVADTR-FDMVQLIDVARQT 411 Query: 2231 ARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIA---XXXXXXXXXXXXXGTYRWM 2401 A+G++Y+H++ ++HRD+K NI E VKI DFG+A G+ WM Sbjct: 412 AQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWM 471 Query: 2402 APEMIKRK---PYNRKVDVYSFGLLLWEMVTGRIPFENL-SPVQVAYAVATDKLKPMDPQ 2569 A E+I+ + PY+ + DVY++G++L+E++TG +P+ ++ S Q+ + V L P + Sbjct: 472 AAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGSRDQIIFMVGRGYLSPDLSK 531 Query: 2570 DY--CPAAVRPLIEQCCALQPEKRPDFWQLVKTLEKIQ 2677 + CP A+R L+ C Q E+RP F Q++ T+E +Q Sbjct: 532 IFSNCPKAMRRLLTDCLKFQREERPLFPQILATIELLQ 569
>P04627:ARAF_MOUSE A-Raf proto-oncogene serine/threonine-protein kinase - Mus musculus| (Mouse) Length = 604 Score = 124 bits (310), Expect = 3e-27 Identities = 80/278 (28%), Positives = 146/278 (52%), Gaps = 9/278 (3%) Frame = +2 Query: 1871 WKLDKAKLLVGHSFASGAHSRLYRGLYDDKPVAIKFIRRPHEDPGGIMAAKLDKQYNTEI 2050 W++ +++ + +G+ ++RG + VA+K ++ A+ + + E+ Sbjct: 301 WEVPPSEVQLLKRIGTGSFGTVFRGRWHGD-VAVKVLKVAQP------TAEQAQAFKNEM 353 Query: 2051 NALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIALEI 2230 L H N++ L P + IIT+ G SL +LH + R + + I +A + Sbjct: 354 QVLRKTRHVNIL-LFMGFMTRPGFAIITQWCEGSSLYHHLHVADTR-FDMVQLIDVARQT 411 Query: 2231 ARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIA---XXXXXXXXXXXXXGTYRWM 2401 A+G++Y+H++ ++HRD+K NI E VKI DFG+A G+ WM Sbjct: 412 AQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWM 471 Query: 2402 APEMIKRK---PYNRKVDVYSFGLLLWEMVTGRIPFENL-SPVQVAYAVATDKLKPMDPQ 2569 A E+I+ + PY+ + DVY++G++L+E++TG +P+ ++ S Q+ + V L P + Sbjct: 472 AAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGSRDQIIFMVGRGYLSPDLSK 531 Query: 2570 DY--CPAAVRPLIEQCCALQPEKRPDFWQLVKTLEKIQ 2677 + CP A+R L+ C Q E+RP F Q++ T+E +Q Sbjct: 532 IFSNCPKAMRRLLTDCLKFQREERPLFPQILATIELLQ 569
>P09769:FGR_HUMAN Proto-oncogene tyrosine-protein kinase FGR - Homo sapiens (Human)| Length = 529 Score = 123 bits (309), Expect = 4e-27 Identities = 81/270 (30%), Positives = 131/270 (48%), Gaps = 4/270 (1%) Frame = +2 Query: 1871 WKLDKAKLLVGHSFASGAHSRLYRGLYDDKP-VAIKFIRRPHEDPGGIMAAKLDKQYNTE 2047 W++ ++ + + +G ++ G ++ VA+K ++ P K + E Sbjct: 256 WEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSP---------KAFLEE 306 Query: 2048 INALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIALE 2227 + L H +++L A P+Y I+TE + GSL +L NPE + L L + + +A + Sbjct: 307 AQVMKLLRHDKLVQLYAVVSEEPIY-IVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQ 365 Query: 2228 IARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIAXXXXXXXXXXXXXGTY--RWM 2401 +A G+ Y+ +HRD++ NIL E KIADFG+A + +W Sbjct: 366 VAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWT 425 Query: 2402 APEMIKRKPYNRKVDVYSFGLLLWEMVT-GRIPFENLSPVQVAYAVATDKLKPMDPQDYC 2578 APE + K DV+SFG+LL E++T GRIP+ ++ +V V P P C Sbjct: 426 APEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPG--C 483 Query: 2579 PAAVRPLIEQCCALQPEKRPDFWQLVKTLE 2668 PA++ +EQ L PE+RP F L LE Sbjct: 484 PASLYEAMEQTWRLDPEERPTFEYLQSFLE 513
>P03949:ABL1_CAEEL Tyrosine-protein kinase abl-1 - Caenorhabditis elegans| Length = 1224 Score = 123 bits (309), Expect = 4e-27 Identities = 87/297 (29%), Positives = 148/297 (49%), Gaps = 8/297 (2%) Frame = +2 Query: 1868 DWKLDKAKLLVGHSFASGAHSRLYRGLYD--DKPVAIKFIRRPHEDPGGIMAAKLDKQYN 2041 +W+LD++++++ + G + +Y G + D +A+K ++ ED + ++ Sbjct: 303 EWELDRSEIIMHNKLGGGQYGDVYEGYWKRHDCTIAVKALK---EDAMPL------HEFL 353 Query: 2042 TEINALSHLYHKNVIKL--VATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTIS 2215 E + L+HKN+++L V TH+ +YIITE + G+L YL + LP + Sbjct: 354 AEAAIMKDLHHKNLVRLLGVCTHEA--PFYIITEFMCNGNLLEYLRRTDKSLLPPIILVQ 411 Query: 2216 IALEIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIAXXXXXXXXXXXXXGTY- 2392 +A +IA G+ Y+ ++ +HRD+ N L E+ VKIADFG+A + Sbjct: 412 MASQIASGMSYLEARHFIHRDLAARNCLVSEHNIVKIADFGLARFMKEDTYTAHAGAKFP 471 Query: 2393 -RWMAPEMIKRKPYNRKVDVYSFGLLLWEMVT-GRIPFENLSPVQVAYAVATDKLKPMDP 2566 +W APE + ++ K DV++FG+LLWE+ T G P+ + V Y + + + MD Sbjct: 472 IKWTAPEGLAFNTFSSKSDVWAFGVLLWEIATYGMAPYPGVELSNV-YGLLENGFR-MDG 529 Query: 2567 QDYCPAAVRPLIEQCCALQPEKRPDFWQLVKTLEKIQSVMSQGGSLD-TLRSSGHKK 2734 CP +V L+ QC P RP F + LE + S S + L+ + KK Sbjct: 530 PQGCPPSVYRLMLQCWNWSPSDRPRFRDIHFNLENLISSNSLNDEVQKQLKKNNDKK 586
>P17713:STK_HYDAT Tyrosine-protein kinase STK - Hydra attenuata (Hydra) (Hydra| vulgaris) Length = 509 Score = 123 bits (308), Expect = 5e-27 Identities = 84/279 (30%), Positives = 133/279 (47%), Gaps = 4/279 (1%) Frame = +2 Query: 1871 WKLDKAKLLVGHSFASGAHSRLYRGLYDDKP-VAIKFIRRPHEDPGGIMAAKLDKQYNTE 2047 W++ + L + +G ++ G++++ VA+K ++ PG + A + E Sbjct: 233 WEIPRESLRLNRKLGAGQFGEVWAGVWNNTTQVAVKTLK-----PGTMSPAS----FLDE 283 Query: 2048 INALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIALE 2227 + L HK++++L A YI+TE + GGSL YL E L L I +A + Sbjct: 284 AGVMKKLRHKHLVQLYAICSDREPIYIVTEYMSGGSLLDYLSKGEGVNLQLPTLIDMAAQ 343 Query: 2228 IARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIAXXXXXXXXXXXXXGTY--RWM 2401 +A G+ ++ +QG +HRD+ NIL EN+ K+ADFG+A + +W Sbjct: 344 VASGMAFLEAQGYIHRDLAARNILVGENYICKVADFGLARLIEDDEYTAHEGAKFPIKWT 403 Query: 2402 APEMIKRKPYNRKVDVYSFGLLLWEMVT-GRIPFENLSPVQVAYAVATDKLKPMDPQDYC 2578 APE + K DV+SFG+L+ E+VT GRIP+ ++ Q V P+ P C Sbjct: 404 APEAALYNRFTIKSDVWSFGILMAEIVTKGRIPYPGMTNAQTIAEVEKGYRMPIMPG--C 461 Query: 2579 PAAVRPLIEQCCALQPEKRPDFWQLVKTLEKIQSVMSQG 2695 P + ++ Q PE RP F L LE QG Sbjct: 462 PEPLYNIMLQTWNKDPENRPTFDYLQGVLEDYFVSTEQG 500
>Q99N57:RAF1_MOUSE RAF proto-oncogene serine/threonine-protein kinase - Mus musculus| (Mouse) Length = 648 Score = 123 bits (308), Expect = 5e-27 Identities = 81/306 (26%), Positives = 157/306 (51%), Gaps = 12/306 (3%) Frame = +2 Query: 1859 STVDWKLDKAKLLVGHSFASGAHSRLYRGLYDDKPVAIKFIRRPHEDPGGIMAAKLDKQY 2038 S+ W+++ +++++ SG+ +Y+G + VA+K ++ P + A + Sbjct: 338 SSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGD-VAVKILKVVDPTPEQLQA------F 390 Query: 2039 NTEINALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISI 2218 E+ L H N++ L + I+T+ G SL +LH E + + + I I Sbjct: 391 RNEVAVLRKTRHVNIL-LFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETK-FQMFQLIDI 448 Query: 2219 ALEIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIA---XXXXXXXXXXXXXGT 2389 A + A+G++Y+H++ ++HRD+K NI E VKI DFG+A G+ Sbjct: 449 ARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGS 508 Query: 2390 YRWMAPEMIKRK---PYNRKVDVYSFGLLLWEMVTGRIPFENL-SPVQVAYAVATDKLKP 2557 WMAPE+I+ + P++ + DVYS+G++L+E++ G +P+ ++ + Q+ + V P Sbjct: 509 VLWMAPEVIRMQDDNPFSFQSDVYSYGIVLYELMAGELPYAHINNRDQIIFMVGRGYASP 568 Query: 2558 MDPQDY--CPAAVRPLIEQCCALQPEKRPDFWQLVKTLEKIQSVM---SQGGSLDTLRSS 2722 + Y CP A++ L+ C E+RP F Q++ ++E +Q + ++ S +L + Sbjct: 569 DLSRLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRA 628 Query: 2723 GHKKGL 2740 H + + Sbjct: 629 AHTEDI 634
>P10398:ARAF_HUMAN A-Raf proto-oncogene serine/threonine-protein kinase - Homo sapiens| (Human) Length = 606 Score = 122 bits (307), Expect = 7e-27 Identities = 79/278 (28%), Positives = 143/278 (51%), Gaps = 9/278 (3%) Frame = +2 Query: 1871 WKLDKAKLLVGHSFASGAHSRLYRGLYDDKPVAIKFIRRPHEDPGGIMAAKLDKQYNTEI 2050 W++ +++ + +G+ ++RG + VA+K ++ A+ + + E+ Sbjct: 303 WEVPPSEVQLLKRIGTGSFGTVFRGRWHGD-VAVKVLKVSQP------TAEQAQAFKNEM 355 Query: 2051 NALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIALEI 2230 L H N++ L P + IIT+ G SL +LH + R + + I +A + Sbjct: 356 QVLRKTRHVNIL-LFMGFMTRPGFAIITQWCEGSSLYHHLHVADTR-FDMVQLIDVARQT 413 Query: 2231 ARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIA---XXXXXXXXXXXXXGTYRWM 2401 A+G++Y+H++ ++HRD+K NI E VKI DFG+A G+ WM Sbjct: 414 AQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWM 473 Query: 2402 APEMIKRK---PYNRKVDVYSFGLLLWEMVTGRIPFENLS-PVQVAYAVATDKLKP--MD 2563 A E+I+ + PY+ + DVY++G++L+E++TG +P+ ++ Q+ + V L P Sbjct: 474 AAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSK 533 Query: 2564 PQDYCPAAVRPLIEQCCALQPEKRPDFWQLVKTLEKIQ 2677 CP A+R L+ C Q E+RP F Q++ T+E +Q Sbjct: 534 ISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQ 571
>P41239:CSK_CHICK Tyrosine-protein kinase CSK - Gallus gallus (Chicken)| Length = 450 Score = 122 bits (306), Expect = 9e-27 Identities = 83/282 (29%), Positives = 133/282 (47%), Gaps = 4/282 (1%) Frame = +2 Query: 1844 AQAVQSTVDWKLDKAKLLVGHSFASGAHSRLYRGLYDDKPVAIKFIRRPHEDPGGIMAAK 2023 AQ S W L+ L + G + G Y VA+K I+ Sbjct: 179 AQDEFSRSGWALNMKDLKLLQIIGKGEFGDVMLGDYRGNKVAVKCIKND----------A 228 Query: 2024 LDKQYNTEINALSHLYHKNVIKL---VATHKCGPVYYIITELLPGGSLRSYLHNPEHRPL 2194 + + E + ++ L H N+++L + K G YI+TE + GSL YL + L Sbjct: 229 TAQAFLAEASVMTQLRHSNLVQLLGVIVEEKSG--LYIVTEYMAKGSLVDYLRSRGRSVL 286 Query: 2195 PLERTISIALEIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIAXXXXXXXXXX 2374 + + +L++ +EY+ + VHRD+ N+L E+ K++DFG+ Sbjct: 287 GGDCLLKFSLDVCEAMEYLEANNFVHRDLAARNVLVSEDNIAKVSDFGLTKEASSTQDTG 346 Query: 2375 XXXGTYRWMAPEMIKRKPYNRKVDVYSFGLLLWEMVT-GRIPFENLSPVQVAYAVATDKL 2551 +W APE ++ K ++ K DV+SFG+LLWE+ + GR+P+ + V V +K Sbjct: 347 KL--PVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRV--EKG 402 Query: 2552 KPMDPQDYCPAAVRPLIEQCCALQPEKRPDFWQLVKTLEKIQ 2677 MDP D CPA V ++++C L P RP F QL + L I+ Sbjct: 403 YKMDPPDGCPAIVYEVMKKCWTLDPGHRPSFHQLREQLVHIK 444
>Q39008:M3K1_ARATH Mitogen-activated protein kinase kinase kinase 1 - Arabidopsis| thaliana (Mouse-ear cress) Length = 608 Score = 122 bits (305), Expect = 1e-26 Identities = 86/257 (33%), Positives = 125/257 (48%), Gaps = 5/257 (1%) Frame = +2 Query: 1901 GHSFASGAHSRLYRGLYDDKPV-AIKFIRRPHEDPGGIMAAKLDKQYNTEINALSHLYHK 2077 G G+ +Y G+ D A+K + + G A + +Q EI LS L H+ Sbjct: 336 GQLLGRGSFGSVYEGISGDGDFFAVKEVSLLDQ---GSQAQECIQQLEGEIKLLSQLQHQ 392 Query: 2078 NVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISI-ALEIARGLEYVH 2254 N+++ T K G YI EL+ GSL + R + +S+ +I GL+Y+H Sbjct: 393 NIVRYRGTAKDGSNLYIFLELVTQGSLLKLYQRYQLR----DSVVSLYTRQILDGLKYLH 448 Query: 2255 SQGVVHRDIKPENILFDENFEVKIADFGIAXXXXXXXXXXXXXGTYRWMAPEMIKRKP-- 2428 +G +HRDIK NIL D N VK+ADFG+A GT WMAPE+I RK Sbjct: 449 DKGFIHRDIKCANILVDANGAVKLADFGLA-KVSKFNDIKSCKGTPFWMAPEVINRKDSD 507 Query: 2429 -YNRKVDVYSFGLLLWEMVTGRIPFENLSPVQVAYAVATDKLKPMDPQDYCPAAVRPLIE 2605 Y D++S G + EM TG+IP+ +L PVQ + + L + D R I Sbjct: 508 GYGSPADIWSLGCTVLEMCTGQIPYSDLEPVQALFRIGRGTLP--EVPDTLSLDARLFIL 565 Query: 2606 QCCALQPEKRPDFWQLV 2656 +C + PE+RP +L+ Sbjct: 566 KCLKVNPEERPTAAELL 582
>P06240:LCK_MOUSE Proto-oncogene tyrosine-protein kinase LCK - Mus musculus (Mouse)| Length = 509 Score = 121 bits (304), Expect = 2e-26 Identities = 80/271 (29%), Positives = 131/271 (48%), Gaps = 4/271 (1%) Frame = +2 Query: 1868 DWKLDKAKLLVGHSFASGAHSRLYRGLYDDKP-VAIKFIRRPHEDPGGIMAAKLDKQYNT 2044 +W++ + L + +G ++ G Y+ VA+K +++ P +A Sbjct: 237 EWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLA--------- 287 Query: 2045 EINALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIAL 2224 E N + L H +++L A P+Y IITE + GSL +L P L + + + +A Sbjct: 288 EANLMKQLQHPRLVRLYAVVTQEPIY-IITEYMENGSLVDFLKTPSGIKLNVNKLLDMAA 346 Query: 2225 EIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIAXXXXXXXXXXXXXGTY--RW 2398 +IA G+ ++ Q +HRD++ NIL + KIADFG+A + +W Sbjct: 347 QIAEGMAFIEEQNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKW 406 Query: 2399 MAPEMIKRKPYNRKVDVYSFGLLLWEMVT-GRIPFENLSPVQVAYAVATDKLKPMDPQDY 2575 APE I + K DV+SFG+LL E+VT GRIP+ ++ +V + ++ M D Sbjct: 407 TAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNL--ERGYRMVRPDN 464 Query: 2576 CPAAVRPLIEQCCALQPEKRPDFWQLVKTLE 2668 CP + L+ C +PE RP F L L+ Sbjct: 465 CPEELYHLMMLCWKERPEDRPTFDYLRSVLD 495
>P42679:MATK_HUMAN Megakaryocyte-associated tyrosine-protein kinase - Homo sapiens| (Human) Length = 507 Score = 121 bits (303), Expect = 2e-26 Identities = 83/302 (27%), Positives = 142/302 (47%), Gaps = 3/302 (0%) Frame = +2 Query: 1775 YFDNVGRRRVSAVENVRSRTVSMAQAVQSTVDWKLDKAKLLVGHSFASGAHSRLYRGLYD 1954 Y + G V R A+ + W L+ L +G G + +G Y Sbjct: 196 YSKDKGAICTKLVRPKRKHGTKSAEEELARAGWLLNLQHLTLGAQIGEGEFGAVLQGEYL 255 Query: 1955 DKPVAIKFIRRPHEDPGGIMAAKLDKQYNTEINALSHLYHKNVIKL--VATHKCGPVYYI 2128 + VA+K I+ + + E ++ + H+N+++L V H+ YI Sbjct: 256 GQKVAVKNIK----------CDVTAQAFLDETAVMTKMQHENLVRLLGVILHQG---LYI 302 Query: 2129 ITELLPGGSLRSYLHNPEHRPLPLERTISIALEIARGLEYVHSQGVVHRDIKPENILFDE 2308 + E + G+L ++L + + + +L +A G+EY+ S+ +VHRD+ NIL E Sbjct: 303 VMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLAARNILVSE 362 Query: 2309 NFEVKIADFGIAXXXXXXXXXXXXXGTYRWMAPEMIKRKPYNRKVDVYSFGLLLWEMVT- 2485 + K++DFG+A +W APE +K + K DV+SFG+LLWE+ + Sbjct: 363 DLVAKVSDFGLAKAERKGLDSSRL--PVKWTAPEALKHGKFTSKSDVWSFGVLLWEVFSY 420 Query: 2486 GRIPFENLSPVQVAYAVATDKLKPMDPQDYCPAAVRPLIEQCCALQPEKRPDFWQLVKTL 2665 GR P+ +S +V+ AV +K M+P + CP V L+ C +P +RP F +L + L Sbjct: 421 GRAPYPKMSLKEVSEAV--EKGYRMEPPEGCPGPVHVLMSSCWEAEPARRPPFRKLAEKL 478 Query: 2666 EK 2671 + Sbjct: 479 AR 480
>P27446:FYN_XIPHE Proto-oncogene tyrosine-protein kinase FYN - Xiphophorus helleri| Length = 537 Score = 121 bits (303), Expect = 2e-26 Identities = 82/270 (30%), Positives = 131/270 (48%), Gaps = 4/270 (1%) Frame = +2 Query: 1871 WKLDKAKLLVGHSFASGAHSRLYRGLYDDKP-VAIKFIRRPHEDPGGIMAAKLDKQYNTE 2047 W++ + L + +G ++ G ++ VA+K ++ P + + E Sbjct: 264 WEIPRESLQLIKRLGNGQFGEVWMGTWNGTTKVAVKTLKPGTMSP---------ESFLEE 314 Query: 2048 INALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIALE 2227 + L H +++L A P+Y I+TE + GSL +L + E R L L + +A + Sbjct: 315 AQIMKKLRHDKLVQLYAVVSEEPIY-IVTEYMSKGSLLDFLKDGEGRALKLPNLVDMAAQ 373 Query: 2228 IARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIAXXXXXXXXXXXXXGTY--RWM 2401 +A G+ Y+ +HRD++ NIL +N KIADFG+A + +W Sbjct: 374 VAAGMAYIERMNYIHRDLRSANILVGDNLVCKIADFGLARLIEDNEYTARQGAKFPIKWT 433 Query: 2402 APEMIKRKPYNRKVDVYSFGLLLWEMVT-GRIPFENLSPVQVAYAVATDKLKPMDPQDYC 2578 APE + K DV+SFG+LL E+VT GR+P+ ++ +V V P PQD C Sbjct: 434 APEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPC-PQD-C 491 Query: 2579 PAAVRPLIEQCCALQPEKRPDFWQLVKTLE 2668 PA++ L+ QC PE+RP F L LE Sbjct: 492 PASLHELMLQCWKKDPEERPTFEYLQAFLE 521
>Q9TTY2:FER_CANFA Proto-oncogene tyrosine-protein kinase FER - Canis familiaris (Dog)| Length = 823 Score = 120 bits (302), Expect = 3e-26 Identities = 129/549 (23%), Positives = 227/549 (41%), Gaps = 27/549 (4%) Frame = +2 Query: 1127 VSVAPLGRDVEQRLQRFVSVAPLGRDVEQRLQRFVSMGKCVTMPIDRDNDKTVAALKHTA 1306 V + L ++ Q Q V+ ++E+R++ S C ++ +D V L Sbjct: 307 VMLKTLAEELIQTQQMLVNKEEAVLELEKRIEE--SSKTC-----EKKSD-IVLLLSQKQ 358 Query: 1307 SLPSLRSTLQP---NEKKASKQKMSLEIPLSPPAKSEKSKAPRARSLVKSPSSMMLLSYL 1477 +L L+ ++Q E K + QK LE + E +S +SM L Sbjct: 359 TLEELKQSVQQLRCTEAKFTAQKELLEQKVQENEGKEPPPVVNYEEDARSVTSMERKERL 418 Query: 1478 NKAYPNQGSSVQNADGSLHKPRSKSPLPSVVPSDTFREARASSQRFTSPPPKRVGSDKSV 1657 +K + S G + P+S + S TF + S++ + G+ + Sbjct: 419 SKFESIRHSIA----GIIRSPKS------ALGSSTFSDTIPISEKPLAEQDWYHGAIPRI 468 Query: 1658 YGKSLGREQCDMAASPDWCSTPVVFGEHSSQKDSSWTRRYF-----DNVGRRRVSAVENV 1822 + L ++Q D GE+ S RR+F DN+ R + N+ Sbjct: 469 EAQDLLKQQGDFLVRESHGKP----GEYVLSVYSDGQRRHFIIQFVDNLYRFEGTGFSNI 524 Query: 1823 ---------------RSRTVSMAQAVQSTVDWKLDKAKLLVGHSFASGAHSRLYRGLYDD 1957 + V + + W L+ + +G G +Y+G+ D Sbjct: 525 PQLIDHHYTTKQVITKKSGVVLLNPIPKDKKWVLNHEDVTLGELLGKGNFGEVYKGILKD 584 Query: 1958 KP-VAIKFIRRPHEDPGGIMAAKLDKQYNTEINALSHLYHKNVIKLVATHKCGPVYYIIT 2134 K VA+K + ED + +L ++ E L H N++KL+ YII Sbjct: 585 KTAVAVKTCK---ED----LPQELKIKFLQEAKILKQYDHPNIVKLIGVCTQRQPIYIIM 637 Query: 2135 ELLPGGSLRSYLHNPEHRPLPLERTISIALEIARGLEYVHSQGVVHRDIKPENILFDENF 2314 EL+PGG S+L + + L++ + +L+ A G+ Y+ S+ +HRD+ N L EN Sbjct: 638 ELVPGGDFLSFLRKKKDE-IKLKQLVKFSLDAASGMSYLESKNCIHRDLAARNCLVGENN 696 Query: 2315 EVKIADFGIAXXXXXXXXXXXXXG--TYRWMAPEMIKRKPYNRKVDVYSFGLLLWEMVT- 2485 +KI+DFG++ +W APE + Y+ + DV+SFG+LLWE + Sbjct: 697 VLKISDFGMSRQEDGGVYSSSGLKQIPIKWTAPEALNYGRYSSESDVWSFGILLWETFSL 756 Query: 2486 GRIPFENLSPVQVAYAVATDKLKPMDPQDYCPAAVRPLIEQCCALQPEKRPDFWQLVKTL 2665 G P+ ++ Q V ++ + +CP + ++ +C +PE RP F +L K L Sbjct: 757 GVCPYPGMTNQQATEQV--ERGYRISAPQHCPEDIFKIMMKCWDYKPENRPKFSELQKEL 814 Query: 2666 EKIQSVMSQ 2692 I+ ++Q Sbjct: 815 TVIKKKVTQ 823
>P00531:MIL_AVIMH Serine/threonine-protein kinase-transforming protein mil - Avian| retrovirus MH2 Length = 380 Score = 120 bits (300), Expect = 4e-26 Identities = 81/306 (26%), Positives = 155/306 (50%), Gaps = 12/306 (3%) Frame = +2 Query: 1859 STVDWKLDKAKLLVGHSFASGAHSRLYRGLYDDKPVAIKFIRRPHEDPGGIMAAKLDKQY 2038 S+ W+++ +++L+ SG+ +Y+G + VA+K ++ P A + Sbjct: 71 SSYYWEIEASEVLLSTRIGSGSFGTVYKGKWHGD-VAVKILKVVDPTPEQFQA------F 123 Query: 2039 NTEINALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISI 2218 E+ L H N++ L + I+T+ G SL +LH E + + + I I Sbjct: 124 RNEVAVLRKTRHVNIL-LFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETK-FQMFQLIDI 181 Query: 2219 ALEIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIA---XXXXXXXXXXXXXGT 2389 A + A+G++Y+H++ ++HRD+K NI VKI DFG+A G+ Sbjct: 182 ARQTAQGMDYLHAKNIIHRDMKSNNIFLHGGLTVKIGDFGLATVKSRWSGSQQVEQPTGS 241 Query: 2390 YRWMAPEMIKRK---PYNRKVDVYSFGLLLWEMVTGRIPFENL-SPVQVAYAVATDKLKP 2557 WMAPE+I+ + P++ + DVYS+G++L+E++TG +P+ ++ + Q+ + V P Sbjct: 242 ILWMAPEVIRMQDSNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASP 301 Query: 2558 MDPQDY--CPAAVRPLIEQCCALQPEKRPDFWQLVKTLEKIQSVM---SQGGSLDTLRSS 2722 + Y CP A++ L+ C E+RP F Q++ ++ +Q + ++ S +L + Sbjct: 302 DLSKLYKNCPKAMKRLVADCLKKVREERPLFPQILSSIALLQHSLPKINRSASEPSLHRA 361 Query: 2723 GHKKGL 2740 H + + Sbjct: 362 SHTEDI 367
>P16092:FGFR1_MOUSE Basic fibroblast growth factor receptor 1 precursor - Mus musculus| (Mouse) Length = 822 Score = 120 bits (300), Expect = 4e-26 Identities = 93/311 (29%), Positives = 152/311 (48%), Gaps = 32/311 (10%) Frame = +2 Query: 1871 WKLDKAKLLVGHSFASGAHSRLYR----GLYDDKP-----VAIKFIRRPHEDPGGIMAAK 2023 W+L + +L++G G ++ GL DKP VA+K ++ + Sbjct: 471 WELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLK----------SDA 520 Query: 2024 LDKQYNTEINALSHLY----HKNVIKLV-ATHKCGPVYYIITELLPGGSLRSYL------ 2170 +K + I+ + + HKN+I L+ A + GP+Y +I E G+LR YL Sbjct: 521 TEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLY-VIVEYASKGNLREYLQARRPP 579 Query: 2171 -----HNPEHRP---LPLERTISIALEIARGLEYVHSQGVVHRDIKPENILFDENFEVKI 2326 +NP H P L + +S A ++ARG+EY+ S+ +HRD+ N+L E+ +KI Sbjct: 580 GLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKI 639 Query: 2327 ADFGIAXXXXXXXXXXXXXG---TYRWMAPEMIKRKPYNRKVDVYSFGLLLWEMVT-GRI 2494 ADFG+A +WMAPE + + Y + DV+SFG+LLWE+ T G Sbjct: 640 ADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGS 699 Query: 2495 PFENLSPVQVAYAVATDKLKPMDPQDYCPAAVRPLIEQCCALQPEKRPDFWQLVKTLEKI 2674 P+ + PV+ + + + + MD C + ++ C P +RP F QLV+ L++I Sbjct: 700 PYPGV-PVEELFKLLKEGHR-MDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRI 757 Query: 2675 QSVMSQGGSLD 2707 ++ S LD Sbjct: 758 VALTSNQEYLD 768
>P11362:FGFR1_HUMAN Basic fibroblast growth factor receptor 1 precursor - Homo sapiens| (Human) Length = 822 Score = 120 bits (300), Expect = 4e-26 Identities = 93/311 (29%), Positives = 152/311 (48%), Gaps = 32/311 (10%) Frame = +2 Query: 1871 WKLDKAKLLVGHSFASGAHSRLYR----GLYDDKP-----VAIKFIRRPHEDPGGIMAAK 2023 W+L + +L++G G ++ GL DKP VA+K ++ + Sbjct: 471 WELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLK----------SDA 520 Query: 2024 LDKQYNTEINALSHLY----HKNVIKLV-ATHKCGPVYYIITELLPGGSLRSYL------ 2170 +K + I+ + + HKN+I L+ A + GP+Y +I E G+LR YL Sbjct: 521 TEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLY-VIVEYASKGNLREYLQARRPP 579 Query: 2171 -----HNPEHRP---LPLERTISIALEIARGLEYVHSQGVVHRDIKPENILFDENFEVKI 2326 +NP H P L + +S A ++ARG+EY+ S+ +HRD+ N+L E+ +KI Sbjct: 580 GLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKI 639 Query: 2327 ADFGIAXXXXXXXXXXXXXG---TYRWMAPEMIKRKPYNRKVDVYSFGLLLWEMVT-GRI 2494 ADFG+A +WMAPE + + Y + DV+SFG+LLWE+ T G Sbjct: 640 ADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGS 699 Query: 2495 PFENLSPVQVAYAVATDKLKPMDPQDYCPAAVRPLIEQCCALQPEKRPDFWQLVKTLEKI 2674 P+ + PV+ + + + + MD C + ++ C P +RP F QLV+ L++I Sbjct: 700 PYPGV-PVEELFKLLKEGHR-MDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRI 757 Query: 2675 QSVMSQGGSLD 2707 ++ S LD Sbjct: 758 VALTSNQEYLD 768
>Q0VBZ0:CSK_BOVIN Tyrosine-protein kinase CSK - Bos taurus (Bovine)| Length = 450 Score = 120 bits (300), Expect = 4e-26 Identities = 79/274 (28%), Positives = 130/274 (47%), Gaps = 4/274 (1%) Frame = +2 Query: 1871 WKLDKAKLLVGHSFASGAHSRLYRGLYDDKPVAIKFIRRPHEDPGGIMAAKLDKQYNTEI 2050 W L+ L + + G + G Y VA+K I+ + + E Sbjct: 188 WALNMKDLKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKND----------ATAQAFLAEA 237 Query: 2051 NALSHLYHKNVIKL---VATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIA 2221 + ++ L H N+++L + K G YI+TE + GSL YL + L + + + Sbjct: 238 SVMTQLRHSNLVQLLGVIVEEKSG--LYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFS 295 Query: 2222 LEIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIAXXXXXXXXXXXXXGTYRWM 2401 L++ +EY+ VHRD+ N+L E+ K++DFG+ +W Sbjct: 296 LDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKL--PVKWT 353 Query: 2402 APEMIKRKPYNRKVDVYSFGLLLWEMVT-GRIPFENLSPVQVAYAVATDKLKPMDPQDYC 2578 APE ++ K ++ K DV+SFG+LLWE+ + GR+P+ + V V +K MD D C Sbjct: 354 APEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRV--EKGYKMDAPDGC 411 Query: 2579 PAAVRPLIEQCCALQPEKRPDFWQLVKTLEKIQS 2680 P AV +++ C L RP F QL + LE+I++ Sbjct: 412 PPAVYEVMKNCWHLDAATRPSFLQLREQLERIKT 445
>P51451:BLK_HUMAN Tyrosine-protein kinase BLK - Homo sapiens (Human)| Length = 505 Score = 119 bits (299), Expect = 6e-26 Identities = 83/270 (30%), Positives = 127/270 (47%), Gaps = 3/270 (1%) Frame = +2 Query: 1868 DWKLDKAKLLVGHSFASGAHSRLYRGLY-DDKPVAIKFIRRPHEDPGGIMAAKLDKQYNT 2044 +W++ + L + SG ++ G Y ++ VAIK ++ P + Sbjct: 233 EWEIPRQSLRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLG--------- 283 Query: 2045 EINALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIAL 2224 E N + L H+ +++L A P+Y I+TE + G L +L E L L R I ++ Sbjct: 284 EANMMKALQHERLVRLYAVVTKEPIY-IVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSA 342 Query: 2225 EIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIAXXXXXXXXXXXXXG-TYRWM 2401 +IA G+ Y+ +HRD++ NIL E KIADFG+A +W Sbjct: 343 QIAEGMAYIERMNSIHRDLRAANILVSEALCCKIADFGLARIIDSEYTAQEGAKFPIKWT 402 Query: 2402 APEMIKRKPYNRKVDVYSFGLLLWEMVT-GRIPFENLSPVQVAYAVATDKLKPMDPQDYC 2578 APE I + K DV+SFG+LL E+VT GR+P+ +S +V + P P Sbjct: 403 APEAIHFGVFTIKADVWSFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPR-PDTCP 461 Query: 2579 PAAVRPLIEQCCALQPEKRPDFWQLVKTLE 2668 P R +I +C +PE+RP F L LE Sbjct: 462 PELYRGVIAECWRSRPEERPTFEFLQSVLE 491
>O88445:AURKC_MOUSE Serine/threonine-protein kinase 13 - Mus musculus (Mouse)| Length = 282 Score = 119 bits (299), Expect = 6e-26 Identities = 79/256 (30%), Positives = 123/256 (48%), Gaps = 2/256 (0%) Frame = +2 Query: 1898 VGHSFASGAHSRLYRGLYDDKP--VAIKFIRRPHEDPGGIMAAKLDKQYNTEINALSHLY 2071 +G G R+Y + VA+K + + + G L+ Q E+ +HL Sbjct: 18 IGRPLGRGKFGRVYLARLKENHFIVALKVLFKSEIEKEG-----LEHQLRREVEIQAHLQ 72 Query: 2072 HKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIALEIARGLEYV 2251 H+N+++L Y+I E PGG L Y H+ L +RT +I E++ L Y Sbjct: 73 HRNILRLYNYFYDDTRIYLILEYAPGGEL--YKELQRHQKLDQQRTATIIQELSDALTYC 130 Query: 2252 HSQGVVHRDIKPENILFDENFEVKIADFGIAXXXXXXXXXXXXXGTYRWMAPEMIKRKPY 2431 H + V+HRDIKPEN+L N EVKI+DFG + GT ++ PEMI +KPY Sbjct: 131 HEKKVIHRDIKPENLLLGLNGEVKISDFGWS-VHTPSLRRKTMCGTLDYLPPEMIAQKPY 189 Query: 2432 NRKVDVYSFGLLLWEMVTGRIPFENLSPVQVAYAVATDKLKPMDPQDYCPAAVRPLIEQC 2611 N VD++ G+L +E++ G+ PFE+ + + + K PA + LI + Sbjct: 190 NEMVDLWCIGVLCYELLVGKPPFESSTSSETYRRIRQVDFK---FPSSVPAGAQDLISKL 246 Query: 2612 CALQPEKRPDFWQLVK 2659 P +R Q++K Sbjct: 247 LRYHPSERLSLAQVLK 262
>Q03497:STE20_YEAST Serine/threonine-protein kinase STE20 - Saccharomyces cerevisiae| (Baker's yeast) Length = 939 Score = 119 bits (298), Expect = 7e-26 Identities = 114/480 (23%), Positives = 202/480 (42%), Gaps = 13/480 (2%) Frame = +2 Query: 1313 PSLRSTLQPNEKKASKQKMSLEIPLSPPAKSEKSKAPRARSLVKSP--SSMMLLSYL--- 1477 P + P S IP S PA S A + ++KSP +S +S L Sbjct: 449 PMSNHVMSPTLNTDSSSANGKFIP-SRPAPKPPSSASASAPIIKSPVMNSAANVSPLKQT 507 Query: 1478 ------NKAYPNQGSSVQNADGSLHKPRSKSPLPSVVPSDTFREARASSQRFTSPPPKRV 1639 N+ PN+ S +NA + + PLP + P+ +++ S T+ P++V Sbjct: 508 HAPTTPNRTSPNRSSISRNAT----LKKEEQPLPPIPPT----KSKTSPIISTAHTPQQV 559 Query: 1640 GSDKSVYGKSLGREQCDMAASPDWCSTPVVFGEHSSQKDSSWTRRYFDNVGRRRVSAVEN 1819 Q A + + +TP + R + ++ E Sbjct: 560 A-------------QSPKAPAQETVTTPT--------SKPAQARSLSKELNEKKREERER 598 Query: 1820 VRSRTVSMAQAVQSTVDWKLDKAKLL-VGHSFASGAHSRLYRGLYDDKPVAIKFIRRPHE 1996 + + + + S D A L+ +G + G ++ G + VAIK + + Sbjct: 599 RKKQLYAKLNEICSDGDPSTKYANLVKIGQGASGGVYTAYEIGT--NVSVAIKQMNLEKQ 656 Query: 1997 DPGGIMAAKLDKQYNTEINALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHN 2176 ++ EI + H N++ + ++ ++I E + GGSL + Sbjct: 657 PKKELII--------NEILVMKGSKHPNIVNFIDSYVLKGDLWVIMEYMEGGSLTDVV-- 706 Query: 2177 PEHRPLPLERTISIALEIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGI-AXXX 2353 H L + ++ E GLE++HS+GV+HRDIK +NIL ++K+ DFG A Sbjct: 707 -THCILTEGQIGAVCRETLSGLEFLHSKGVLHRDIKSDNILLSMEGDIKLTDFGFCAQIN 765 Query: 2354 XXXXXXXXXXGTYRWMAPEMIKRKPYNRKVDVYSFGLLLWEMVTGRIPFENLSPVQVAYA 2533 GT WMAPE++ RK Y KVD++S G+++ EM+ G P+ N +P++ Y Sbjct: 766 ELNLKRTTMVGTPYWMAPEVVSRKEYGPKVDIWSLGIMIIEMIEGEPPYLNETPLRALYL 825 Query: 2534 VATDKLKPMDPQDYCPAAVRPLIEQCCALQPEKRPDFWQLVKTLEKIQSVMSQGGSLDTL 2713 +AT+ + + ++++ ++ C ++PE R +L+ E I + SL L Sbjct: 826 IATNGTPKLKEPENLSSSLKKFLDWCLCVEPEDRASATELLHD-EYITEIAEANSSLAPL 884
>P53668:LIMK1_MOUSE LIM domain kinase 1 - Mus musculus (Mouse)| Length = 647 Score = 119 bits (298), Expect = 7e-26 Identities = 78/261 (29%), Positives = 123/261 (47%), Gaps = 24/261 (9%) Frame = +2 Query: 1979 IRRPHEDPGGIMAAK--------LDKQYNTEINALSHLYHKNVIKLVATHKCGPVYYIIT 2134 I+ H + G +M K + + E+ + L H NV+K + IT Sbjct: 354 IKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGVLYKDKRLNFIT 413 Query: 2135 ELLPGGSLRSYLHNPEHRPLPLERTISIALEIARGLEYVHSQGVVHRDIKPENILFDENF 2314 E + GG+LR + N + + P + +S A +IA G+ Y+HS ++HRD+ N L EN Sbjct: 414 EYIKGGTLRGIIKNMDSQ-YPWSQRVSFAKDIASGMAYLHSMNIIHRDLNSHNCLVRENR 472 Query: 2315 EVKIADFGIA---------------XXXXXXXXXXXXXGTYRWMAPEMIKRKPYNRKVDV 2449 V +ADFG+A G WMAPEMI + Y+ KVDV Sbjct: 473 NVVVADFGLARLMIDEKNQSEDLRSLKKPDRKKRYTVVGNPYWMAPEMINGRSYDEKVDV 532 Query: 2450 YSFGLLLWEMVTGRIPFE-NLSPVQVAYAVATDKLKPMDPQDYCPAAVRPLIEQCCALQP 2626 +SFG++L E++ GR+ + + P + + + CP + P+ +CC L P Sbjct: 533 FSFGIVLCEII-GRVNADPDYLPRTMDFGLNVRGFLDRYCPPNCPPSFFPITVRCCDLDP 591 Query: 2627 EKRPDFWQLVKTLEKIQSVMS 2689 EKRP F +L + LE ++ +S Sbjct: 592 EKRPSFVKLEQWLETLRMHLS 612
>P08631:HCK_HUMAN Tyrosine-protein kinase HCK - Homo sapiens (Human)| Length = 526 Score = 119 bits (298), Expect = 7e-26 Identities = 83/276 (30%), Positives = 136/276 (49%), Gaps = 4/276 (1%) Frame = +2 Query: 1871 WKLDKAKLLVGHSFASGAHSRLYRGLYDDKP-VAIKFIRRPHEDPGGIMAAKLDKQYNTE 2047 W++ + L + +G ++ Y+ VA+K ++ PG + + + E Sbjct: 255 WEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMK-----PGSMSV----EAFLAE 305 Query: 2048 INALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIALE 2227 N + L H ++KL A P+Y IITE + GSL +L + E PL + I + + Sbjct: 306 ANVMKTLQHDKLVKLHAVVTKEPIY-IITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQ 364 Query: 2228 IARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIAXXXXXXXXXXXXXGTY--RWM 2401 IA G+ ++ + +HRD++ NIL + KIADFG+A + +W Sbjct: 365 IAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWT 424 Query: 2402 APEMIKRKPYNRKVDVYSFGLLLWEMVT-GRIPFENLSPVQVAYAVATDKLKPMDPQDYC 2578 APE I + K DV+SFG+LL E+VT GRIP+ +S +V A+ ++ M + C Sbjct: 425 APEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRAL--ERGYRMPRPENC 482 Query: 2579 PAAVRPLIEQCCALQPEKRPDFWQLVKTLEKIQSVM 2686 P + ++ +C +PE+RP T E IQSV+ Sbjct: 483 PEELYNIMMRCWKNRPEERP-------TFEYIQSVL 511
>P70451:FER_MOUSE Proto-oncogene tyrosine-protein kinase FER - Mus musculus (Mouse)| Length = 823 Score = 119 bits (298), Expect = 7e-26 Identities = 82/277 (29%), Positives = 134/277 (48%), Gaps = 4/277 (1%) Frame = +2 Query: 1871 WKLDKAKLLVGHSFASGAHSRLYRGLYDDK-PVAIKFIRRPHEDPGGIMAAKLDKQYNTE 2047 W L+ + +G G +Y+G DK PVAIK + ED + +L ++ E Sbjct: 557 WVLNHEDVSLGELLGKGNFGEVYKGTLKDKTPVAIKTCK---ED----LPQELKIKFLQE 609 Query: 2048 INALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIALE 2227 L H N++KL+ YII EL+PGG ++L + L L++ + +L+ Sbjct: 610 AKILKQYDHPNIVKLIGVCTQRQPVYIIMELVPGGDFLTFLRKRKDE-LKLKQLVRFSLD 668 Query: 2228 IARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIAXXXXXXXXXXXXXG--TYRWM 2401 +A G+ Y+ S+ +HRD+ N L EN +KI+DFG++ +W Sbjct: 669 VAAGMLYLESKNCIHRDLAARNCLVGENNTLKISDFGMSRQEDGGVYSSSGLKQIPIKWT 728 Query: 2402 APEMIKRKPYNRKVDVYSFGLLLWEMVT-GRIPFENLSPVQVAYAVATDKLKPMDPQDYC 2578 APE + Y+ + DV+SFG+LLWE + G P+ ++ Q V ++ M C Sbjct: 729 APEALNYGRYSSESDVWSFGILLWETFSLGVCPYPGMTNQQAREQV--ERGYRMSAPQNC 786 Query: 2579 PAAVRPLIEQCCALQPEKRPDFWQLVKTLEKIQSVMS 2689 P V ++ +C +PE RP F L K L I+ +++ Sbjct: 787 PEEVFTIMMKCWDYKPENRPKFNDLHKELTVIKKMIT 823
>P43298:TMK1_ARATH Putative receptor protein kinase TMK1 precursor - Arabidopsis| thaliana (Mouse-ear cress) Length = 942 Score = 119 bits (297), Expect = 1e-25 Identities = 80/279 (28%), Positives = 134/279 (48%), Gaps = 26/279 (9%) Frame = +2 Query: 1916 SGAHSRLYRG-LYDDKPVAIKFIRRPHEDPGGIMAAKLDKQYNTEINALSHLYHKNVIKL 2092 SG +Y+G L+D +A+K + G++A K ++ +EI L+ + H++++ L Sbjct: 596 SGGFGVVYKGELHDGTKIAVKRMEN------GVIAGKGFAEFKSEIAVLTKVRHRHLVTL 649 Query: 2093 VATHKCGPVYYIITELLPGGSLRSYLHNPEH---RPLPLERTISIALEIARGLEYVHS-- 2257 + G ++ E +P G+L +L +PL ++ +++AL++ARG+EY+H Sbjct: 650 LGYCLDGNEKLLVYEYMPQGTLSRHLFEWSEEGLKPLLWKQRLTLALDVARGVEYLHGLA 709 Query: 2258 -QGVVHRDIKPENILFDENFEVKIADFGIAXXXXXXXXXXXXX--GTYRWMAPEMIKRKP 2428 Q +HRD+KP NIL ++ K+ADFG+ GT+ ++APE Sbjct: 710 HQSFIHRDLKPSNILLGDDMRAKVADFGLVRLAPEGKGSIETRIAGTFGYLAPEYAVTGR 769 Query: 2429 YNRKVDVYSFGLLLWEMVTGRIPFENLSPVQVAYAV----------------ATDKLKPM 2560 KVDVYSFG++L E++TGR + P + + V A D + Sbjct: 770 VTTKVDVYSFGVILMELITGRKSLDESQPEESIHLVSWFKRMYINKEASFKKAIDTTIDL 829 Query: 2561 DPQDYCPA-AVRPLIEQCCALQPEKRPDFWQLVKTLEKI 2674 D + V L CCA +P +RPD V L + Sbjct: 830 DEETLASVHTVAELAGHCCAREPYQRPDMGHAVNILSSL 868
>P42689:SRK3_SPOLA Tyrosine-protein kinase SRK3 - Spongilla lacustris (Freshwater| sponge) Length = 334 Score = 119 bits (297), Expect = 1e-25 Identities = 76/280 (27%), Positives = 136/280 (48%), Gaps = 4/280 (1%) Frame = +2 Query: 1868 DWKLDKAKLLVGHSFASGAHSRLYRGLYDDKP-VAIKFIRRPHEDPGGIMAAKLDKQYNT 2044 +W++D+ + + G ++ G+++ VA+K ++ + K + Sbjct: 58 EWEIDRTTIQLQRKLGQGNFGEVWAGVWNGTTAVAVKTLKPDTMEV---------KDFVQ 108 Query: 2045 EINALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIAL 2224 E + ++H N+++L A G YI+TEL+ GS+ YL + E + + L + + ++ Sbjct: 109 EAQVMKKIHHPNLLQLYAVCTIGEPIYIVTELMKYGSMLEYLKHGEGKNITLHQMVDMSA 168 Query: 2225 EIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIAXXXXXXXXXXXXXGTY--RW 2398 +IA G+ Y+ + +HRD+ NIL E K+ADFG+A + +W Sbjct: 169 QIASGMTYLEAHSYIHRDLAARNILVGEGNVCKVADFGLARVIKEDIYNPREGTKFPIKW 228 Query: 2399 MAPEMIKRKPYNRKVDVYSFGLLLWEMVT-GRIPFENLSPVQVAYAVATDKLKPMDPQDY 2575 APE + K DV+SFG+L+ E+VT GR+P+ ++ QV AV D+ M + Sbjct: 229 TAPEAALYNRFTIKSDVWSFGVLISEIVTHGRMPYPGMTNRQVLEAV--DRGYRMPCPEG 286 Query: 2576 CPAAVRPLIEQCCALQPEKRPDFWQLVKTLEKIQSVMSQG 2695 CP + ++ C +P+ RP F L LE ++G Sbjct: 287 CPDPLYKIMLSCWKHEPDDRPTFESLKNLLEDYYVSAAEG 326
>P41240:CSK_HUMAN Tyrosine-protein kinase CSK - Homo sapiens (Human)| Length = 450 Score = 119 bits (297), Expect = 1e-25 Identities = 79/274 (28%), Positives = 130/274 (47%), Gaps = 4/274 (1%) Frame = +2 Query: 1871 WKLDKAKLLVGHSFASGAHSRLYRGLYDDKPVAIKFIRRPHEDPGGIMAAKLDKQYNTEI 2050 W L+ +L + + G + G Y VA+K I+ + + E Sbjct: 188 WALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKND----------ATAQAFLAEA 237 Query: 2051 NALSHLYHKNVIKL---VATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIA 2221 + ++ L H N+++L + K G YI+TE + GSL YL + L + + + Sbjct: 238 SVMTQLRHSNLVQLLGVIVEEKGG--LYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFS 295 Query: 2222 LEIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIAXXXXXXXXXXXXXGTYRWM 2401 L++ +EY+ VHRD+ N+L E+ K++DFG+ +W Sbjct: 296 LDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKL--PVKWT 353 Query: 2402 APEMIKRKPYNRKVDVYSFGLLLWEMVT-GRIPFENLSPVQVAYAVATDKLKPMDPQDYC 2578 APE ++ K ++ K DV+SFG+LLWE+ + GR+P+ + V V +K MD D C Sbjct: 354 APEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRV--EKGYKMDAPDGC 411 Query: 2579 PAAVRPLIEQCCALQPEKRPDFWQLVKTLEKIQS 2680 P AV +++ C L RP F QL + LE I++ Sbjct: 412 PPAVYEVMKNCWHLDAAMRPSFLQLREQLEHIKT 445
>Q6CVA2:STE20_KLULA Serine/threonine-protein kinase STE20 - Kluyveromyces lactis (Yeast)| (Candida sphaerica) Length = 989 Score = 118 bits (296), Expect = 1e-25 Identities = 104/425 (24%), Positives = 179/425 (42%), Gaps = 6/425 (1%) Frame = +2 Query: 1379 IPLSPPAKSEKSKAPRARSLVKSPSSMMLLSYLNKAYPN-QGSSVQNADGSLHKP----R 1543 IP P K + S R + SP ++ L P Q S Q++ K + Sbjct: 546 IPTRPAPKPQGSSTVSRRVEIPSP-----INSLGHGTPKVQRSDTQSSSIFSFKKMPTLK 600 Query: 1544 SKSPLPSVVPSDTFREARASSQRFTSPPPKRVGSDKSVYGKSLGREQCDMAASPDWCSTP 1723 S+ PLP + P + A R PPK EQ + A P + Sbjct: 601 SEQPLPPI-PKAAEKPANLLPARAAPTPPKPAIPTTP--------EQSSIPAIPSGLAVE 651 Query: 1724 VVFGEHSSQKDSSWTRRYFDNVGRRRVSAVENVRSRTVSMAQAVQSTVDWKLDKAKLLVG 1903 V + S + TR+ + R + ++S+ + + KL K + +G Sbjct: 652 V---KEESNTSNVQTRKAQEKKREERKRKNQQIQSKLTEICTTGDPS---KLYKNLIKIG 705 Query: 1904 HSFASGAHSRLYRGLYDDKPVAIKFIRRPHEDPGGIMAAKLDKQYNTEINALSHLYHKNV 2083 + G ++ G + VAIK + + ++ EI + H N+ Sbjct: 706 QGASGGVYTAYELGT--NASVAIKQMNLEKQPKKELIV--------NEILVMKGSKHNNI 755 Query: 2084 IKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIALEIARGLEYVHSQG 2263 + + ++ +++ E + GGSL + H L + +++ E +GL+++HS+G Sbjct: 756 VNFIDSYLFRGDLWVVMEYMEGGSLTDVV---THCILTEGQIGAVSRETLKGLQFLHSKG 812 Query: 2264 VVHRDIKPENILFDENFEVKIADFGI-AXXXXXXXXXXXXXGTYRWMAPEMIKRKPYNRK 2440 V+HRDIK +NIL N ++K+ DFG A GT WMAPE++ RK Y K Sbjct: 813 VIHRDIKSDNILLSMNGDIKLTDFGFCAQINEVNLKRTTMVGTPYWMAPEVVSRKEYGPK 872 Query: 2441 VDVYSFGLLLWEMVTGRIPFENLSPVQVAYAVATDKLKPMDPQDYCPAAVRPLIEQCCAL 2620 VD++S G+++ EM+ G P+ N +P++ Y +AT+ + + + C + Sbjct: 873 VDIWSLGIMIIEMIEGEPPYLNETPLRALYLIATNGTPKLKDPGNLSHKMAMFLNWCLMV 932 Query: 2621 QPEKR 2635 PE R Sbjct: 933 DPEDR 937
>Q8R9T6:PKN1_THETN Probable serine/threonine-protein kinase Sps1 - Thermoanaerobacter| tengcongensis Length = 625 Score = 118 bits (296), Expect = 1e-25 Identities = 70/227 (30%), Positives = 114/227 (50%), Gaps = 3/227 (1%) Frame = +2 Query: 1964 VAIKFIRRPHEDPGGIMAAKLDKQYNTEINALSHLYHKNVIKLVATHKCGPVYYIITELL 2143 VAIK +R P K++ E A + L H N++ + + G +YYI+ E + Sbjct: 36 VAIKILR-----PEFAADENFVKKFKRESQAAASLSHPNIVGIYDVGQEGDIYYIVMEYV 90 Query: 2144 PGGSLRSYLHNPEHRPLPLERTISIALEIARGLEYVHSQGVVHRDIKPENILFDENFEVK 2323 G +L+ + PL ++R + IA ++ R L++ H ++HRDIKP+NIL + VK Sbjct: 91 KGRTLKELIRE-NGGPLEVKRAVEIASQVCRALDHAHKNKIIHRDIKPQNILVTDEDVVK 149 Query: 2324 IADFGI--AXXXXXXXXXXXXXGTYRWMAPEMIKRKPYNRKVDVYSFGLLLWEMVTGRIP 2497 + DFGI A GT + +PE K + + D+YS G++L+EM+TG++P Sbjct: 150 VTDFGIARAANGATITYTGDVIGTAYYFSPEQAKGSIVDERTDIYSLGIVLFEMLTGKVP 209 Query: 2498 FENLSPVQVAYA-VATDKLKPMDPQDYCPAAVRPLIEQCCALQPEKR 2635 FE SP+ VA + D L P + P + ++ + P R Sbjct: 210 FEGDSPISVALKHIQEDILPPSRLNEKVPEELDKIVLKATQKDPNLR 256
>P32577:CSK_RAT Tyrosine-protein kinase CSK - Rattus norvegicus (Rat)| Length = 450 Score = 118 bits (296), Expect = 1e-25 Identities = 79/274 (28%), Positives = 130/274 (47%), Gaps = 4/274 (1%) Frame = +2 Query: 1871 WKLDKAKLLVGHSFASGAHSRLYRGLYDDKPVAIKFIRRPHEDPGGIMAAKLDKQYNTEI 2050 W L+ +L + + G + G Y VA+K I+ + + E Sbjct: 188 WALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKND----------ATAQAFLAEA 237 Query: 2051 NALSHLYHKNVIKL---VATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIA 2221 + ++ L H N+++L + K G YI+TE + GSL YL + L + + + Sbjct: 238 SVMTQLRHSNLVQLLGVIVEEKGG--LYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFS 295 Query: 2222 LEIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIAXXXXXXXXXXXXXGTYRWM 2401 L++ +EY+ VHRD+ N+L E+ K++DFG+ +W Sbjct: 296 LDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKL--PVKWT 353 Query: 2402 APEMIKRKPYNRKVDVYSFGLLLWEMVT-GRIPFENLSPVQVAYAVATDKLKPMDPQDYC 2578 APE ++ K ++ K DV+SFG+LLWE+ + GR+P+ + V V +K MD D C Sbjct: 354 APEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRV--EKGYKMDAPDGC 411 Query: 2579 PAAVRPLIEQCCALQPEKRPDFWQLVKTLEKIQS 2680 P AV +++ C L RP F QL + LE I++ Sbjct: 412 PPAVYDVMKNCWHLDAATRPTFLQLREQLEHIRT 445
>P41241:CSK_MOUSE Tyrosine-protein kinase CSK - Mus musculus (Mouse)| Length = 450 Score = 118 bits (296), Expect = 1e-25 Identities = 79/274 (28%), Positives = 130/274 (47%), Gaps = 4/274 (1%) Frame = +2 Query: 1871 WKLDKAKLLVGHSFASGAHSRLYRGLYDDKPVAIKFIRRPHEDPGGIMAAKLDKQYNTEI 2050 W L+ +L + + G + G Y VA+K I+ + + E Sbjct: 188 WALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKND----------ATAQAFLAEA 237 Query: 2051 NALSHLYHKNVIKL---VATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIA 2221 + ++ L H N+++L + K G YI+TE + GSL YL + L + + + Sbjct: 238 SVMTQLRHSNLVQLLGVIVEEKGG--LYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFS 295 Query: 2222 LEIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIAXXXXXXXXXXXXXGTYRWM 2401 L++ +EY+ VHRD+ N+L E+ K++DFG+ +W Sbjct: 296 LDVLEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKL--PVKWT 353 Query: 2402 APEMIKRKPYNRKVDVYSFGLLLWEMVT-GRIPFENLSPVQVAYAVATDKLKPMDPQDYC 2578 APE ++ K ++ K DV+SFG+LLWE+ + GR+P+ + V V +K MD D C Sbjct: 354 APEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRV--EKGYKMDAPDGC 411 Query: 2579 PAAVRPLIEQCCALQPEKRPDFWQLVKTLEKIQS 2680 P AV +++ C L RP F QL + LE I++ Sbjct: 412 PPAVYDVMKNCSHLDAATRPTFLQLREQLEHIKT 445
>Q05876:FYN_CHICK Proto-oncogene tyrosine-protein kinase Fyn - Gallus gallus (Chicken)| Length = 534 Score = 118 bits (295), Expect = 2e-25 Identities = 81/270 (30%), Positives = 129/270 (47%), Gaps = 4/270 (1%) Frame = +2 Query: 1871 WKLDKAKLLVGHSFASGAHSRLYRGLYD-DKPVAIKFIRRPHEDPGGIMAAKLDKQYNTE 2047 W++ + L + G + ++RG ++ + VAIK ++ P + + E Sbjct: 261 WEVARDSLFLEQKLGQGCFAEVWRGTWNGNTKVAIKTLKPGTMSP---------ESFLEE 311 Query: 2048 INALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIALE 2227 + L H +++L A P+Y I+TE + GSL +L + E R L L + +A + Sbjct: 312 AQIMKKLKHDKLVQLYAVVSRRPIY-IVTEYMSKGSLLIFLKDGEGRALKLPNLVDMAAQ 370 Query: 2228 IARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIAXXXXXXXXXXXXXGTY--RWM 2401 +A G+ Y+ +HRD++ NIL KIADFG+A + +W Sbjct: 371 VAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWT 430 Query: 2402 APEMIKRKPYNRKVDVYSFGLLLWEMVT-GRIPFENLSPVQVAYAVATDKLKPMDPQDYC 2578 APE + K DV+SFG+LL E+VT GR+P+ ++ +V V P PQD C Sbjct: 431 APEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPC-PQD-C 488 Query: 2579 PAAVRPLIEQCCALQPEKRPDFWQLVKTLE 2668 P ++ L+ C PE+RP F L LE Sbjct: 489 PISLHELMIHCWKKDPEERPTFEYLQGFLE 518
>P00530:FPS_FUJSV Tyrosine-protein kinase transforming protein FPS - Fujinami sarcoma| virus Length = 873 Score = 118 bits (295), Expect = 2e-25 Identities = 76/264 (28%), Positives = 127/264 (48%), Gaps = 6/264 (2%) Frame = +2 Query: 1871 WKLDKAKLLVGHSFASGAHSRLYRGLY--DDKPVAIKFIRRPHEDPGGIMAAKLDKQYNT 2044 W L+ +L+G G ++ G D+ PVA+K R + +L ++ Sbjct: 605 WVLNHEDVLLGERIGRGNFGEVFSGRLRADNTPVAVKSCRET-------LPPELKAKFLQ 657 Query: 2045 EINALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIAL 2224 E L H N+++L+ YI+ EL+ GG S+L + R L +++ I + Sbjct: 658 EARILKQCNHPNIVRLIGVCTQKQPIYIVMELVQGGDFLSFLRSKGPR-LKMKKLIKMME 716 Query: 2225 EIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIAXXXXXXXXXXXXXG---TYR 2395 A G+EY+ S+ +HRD+ N L E +KI+DFG++ + Sbjct: 717 NAAAGMEYLESKHCIHRDLAARNCLVTEKNTLKISDFGMSRQEEDGVYASTGGMKQIPVK 776 Query: 2396 WMAPEMIKRKPYNRKVDVYSFGLLLWEMVT-GRIPFENLSPVQVAYAVATDKLKPMDPQD 2572 W APE + Y+ + DV+SFG+LLWE + G +P+ NLS Q A+ ++ ++P + Sbjct: 777 WTAPEALNYGWYSSESDVWSFGILLWEAFSLGAVPYANLSNQQTREAI--EQGVRLEPPE 834 Query: 2573 YCPAAVRPLIEQCCALQPEKRPDF 2644 CP V L+++C P +RP F Sbjct: 835 QCPEDVYRLMQRCWEYDPHRRPSF 858
>Q04589:FGFR1_RAT Basic fibroblast growth factor receptor 1 precursor - Rattus| norvegicus (Rat) Length = 822 Score = 117 bits (294), Expect = 2e-25 Identities = 93/311 (29%), Positives = 151/311 (48%), Gaps = 32/311 (10%) Frame = +2 Query: 1871 WKLDKAKLLVGHSFASGAHSRLYR----GLYDDKP-----VAIKFIRRPHEDPGGIMAAK 2023 W+L + +L++G G ++ GL DKP VA+K ++ + Sbjct: 471 WELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLK----------SDA 520 Query: 2024 LDKQYNTEINALSHLY----HKNVIKLV-ATHKCGPVYYIITELLPGGSLRSYL------ 2170 +K + I+ + + HKN+I L+ A + GP+Y +I E G+LR YL Sbjct: 521 TEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLY-VIVEYASKGNLREYLQARRPP 579 Query: 2171 -----HNPEHRP---LPLERTISIALEIARGLEYVHSQGVVHRDIKPENILFDENFEVKI 2326 +NP H P L + +S A ++ARG+EY+ S+ +HRD+ N+L E+ +KI Sbjct: 580 GLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKI 639 Query: 2327 ADFGIAXXXXXXXXXXXXXG---TYRWMAPEMIKRKPYNRKVDVYSFGLLLWEMVT-GRI 2494 ADFG+A +WMAPE + + Y + DV+SFG+LLWE+ T G Sbjct: 640 ADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGS 699 Query: 2495 PFENLSPVQVAYAVATDKLKPMDPQDYCPAAVRPLIEQCCALQPEKRPDFWQLVKTLEKI 2674 P + PV+ + + + + MD C + ++ C P +RP F QLV+ L++I Sbjct: 700 PNPGV-PVEELFKLLKEGHR-MDKPSNCTNELYMMMRDCWNAVPSQRPTFKQLVEDLDRI 757 Query: 2675 QSVMSQGGSLD 2707 ++ S LD Sbjct: 758 VALTSNQEYLD 768
>P09760:FER_RAT Proto-oncogene tyrosine-protein kinase FER - Rattus norvegicus (Rat)| Length = 323 Score = 117 bits (294), Expect = 2e-25 Identities = 80/273 (29%), Positives = 130/273 (47%), Gaps = 4/273 (1%) Frame = +2 Query: 1871 WKLDKAKLLVGHSFASGAHSRLYRGLYDDK-PVAIKFIRRPHEDPGGIMAAKLDKQYNTE 2047 W L+ + +G G +Y+G DK PVA+K + ED + +L ++ E Sbjct: 57 WVLNHEDVSLGELLGKGNFGEVYKGTLKDKTPVAVKTCK---ED----LPQELKIKFLQE 109 Query: 2048 INALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIALE 2227 L H N++KL+ YII EL+PGG S+L + L L++ + +L+ Sbjct: 110 AKILKQYDHPNIVKLIGVCTQRQPVYIIMELVPGGDFLSFLRKRKDE-LKLKQLVRFSLD 168 Query: 2228 IARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIAXXXXXXXXXXXXXG--TYRWM 2401 +A G+ Y+ + +HRD+ N L EN +KI+DFG++ +W Sbjct: 169 VAAGMLYLEGKNCIHRDLAARNCLVGENNTLKISDFGMSRQEDGGVYSSSGLKQIPIKWT 228 Query: 2402 APEMIKRKPYNRKVDVYSFGLLLWEMVT-GRIPFENLSPVQVAYAVATDKLKPMDPQDYC 2578 APE + Y+ + DV+SFG+LLWE + G P+ ++ Q V ++ M C Sbjct: 229 APEALNYGRYSSESDVWSFGILLWETFSLGVCPYPGMTNQQAREQV--ERGYRMSAPQNC 286 Query: 2579 PAAVRPLIEQCCALQPEKRPDFWQLVKTLEKIQ 2677 P + ++ +C +PE RP F L K L I+ Sbjct: 287 PEEIFTIMMKCWDYKPENRPKFSDLHKELTAIK 319
>P12931:SRC_HUMAN Proto-oncogene tyrosine-protein kinase Src - Homo sapiens (Human)| Length = 536 Score = 117 bits (293), Expect = 3e-25 Identities = 86/314 (27%), Positives = 144/314 (45%), Gaps = 4/314 (1%) Frame = +2 Query: 1739 HSSQKDSSWTRRYFDNVGRRRVSAVENVRSRTVSMAQAVQSTVDWKLDKAKLLVGHSFAS 1918 +S Q+ ++ ++ D + R + + +T +A+ W++ + L + Sbjct: 224 NSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDA-----WEIPRESLRLEVKLGQ 278 Query: 1919 GAHSRLYRGLYDDKP-VAIKFIRRPHEDPGGIMAAKLDKQYNTEINALSHLYHKNVIKLV 2095 G ++ G ++ VAIK ++ P + E + L H+ +++L Sbjct: 279 GCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQ---------EAQVMKKLRHEKLVQLY 329 Query: 2096 ATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIALEIARGLEYVHSQGVVHR 2275 A P+Y I+TE + GSL +L + L L + + +A +IA G+ YV VHR Sbjct: 330 AVVSEEPIY-IVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHR 388 Query: 2276 DIKPENILFDENFEVKIADFGIAXXXXXXXXXXXXXGTY--RWMAPEMIKRKPYNRKVDV 2449 D++ NIL EN K+ADFG+A + +W APE + K DV Sbjct: 389 DLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDV 448 Query: 2450 YSFGLLLWEMVT-GRIPFENLSPVQVAYAVATDKLKPMDPQDYCPAAVRPLIEQCCALQP 2626 +SFG+LL E+ T GR+P+ + +V V P P+ CP ++ L+ QC +P Sbjct: 449 WSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPE--CPESLHDLMCQCWRKEP 506 Query: 2627 EKRPDFWQLVKTLE 2668 E+RP F L LE Sbjct: 507 EERPTFEYLQAFLE 520
>P50545:HCK_RAT Tyrosine-protein kinase HCK - Rattus norvegicus (Rat)| Length = 524 Score = 117 bits (293), Expect = 3e-25 Identities = 81/276 (29%), Positives = 134/276 (48%), Gaps = 4/276 (1%) Frame = +2 Query: 1871 WKLDKAKLLVGHSFASGAHSRLYRGLYDDKP-VAIKFIRRPHEDPGGIMAAKLDKQYNTE 2047 W++ + L + +G ++ Y+ VA+K ++ PG + + + E Sbjct: 253 WEIPRESLQMEKKLGAGQFGEVWMATYNKHTKVAVKTMK-----PGSMSV----EAFLAE 303 Query: 2048 INALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIALE 2227 N + L H ++KL A P++ I+TE + GSL +L + E PL + I + + Sbjct: 304 ANLMKTLQHDKLVKLHAVVSQEPIF-IVTEFMAKGSLLDFLKSEEGSKQPLPKLIDFSAQ 362 Query: 2228 IARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIAXXXXXXXXXXXXXGTY--RWM 2401 I+ G+ ++ + +HRD++ NIL + KIADFG+A + +W Sbjct: 363 ISEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARIIEDNEYTAREGAKFPIKWT 422 Query: 2402 APEMIKRKPYNRKVDVYSFGLLLWEMVT-GRIPFENLSPVQVAYAVATDKLKPMDPQDYC 2578 APE I + K DV+SFG+LL E+VT GRIP+ +S +V A+ P D C Sbjct: 423 APEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALEHGYRMPR--PDNC 480 Query: 2579 PAAVRPLIEQCCALQPEKRPDFWQLVKTLEKIQSVM 2686 P + ++ +C +PE+RP T E IQSV+ Sbjct: 481 PEELYSIMIRCWKNRPEERP-------TFEYIQSVL 509
>P08103:HCK_MOUSE Tyrosine-protein kinase HCK - Mus musculus (Mouse)| Length = 524 Score = 117 bits (293), Expect = 3e-25 Identities = 81/276 (29%), Positives = 134/276 (48%), Gaps = 4/276 (1%) Frame = +2 Query: 1871 WKLDKAKLLVGHSFASGAHSRLYRGLYDDKP-VAIKFIRRPHEDPGGIMAAKLDKQYNTE 2047 W++ + L + +G ++ Y+ VA+K ++ PG + + + E Sbjct: 253 WEIPRESLQMEKKLGAGQFGEVWMATYNKHTKVAVKTMK-----PGSMSV----EAFLAE 303 Query: 2048 INALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIALE 2227 N + L H ++KL A P++ I+TE + GSL +L + E PL + I + + Sbjct: 304 ANLMKSLQHDKLVKLHAVVSQEPIF-IVTEFMAKGSLLDFLKSEEGSKQPLPKLIDFSAQ 362 Query: 2228 IARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIAXXXXXXXXXXXXXGTY--RWM 2401 I+ G+ ++ + +HRD++ NIL + KIADFG+A + +W Sbjct: 363 ISEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARIIEDNEYTAREGAKFPIKWT 422 Query: 2402 APEMIKRKPYNRKVDVYSFGLLLWEMVT-GRIPFENLSPVQVAYAVATDKLKPMDPQDYC 2578 APE I + K DV+SFG+LL E+VT GRIP+ +S +V A+ P D C Sbjct: 423 APEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALEHGYRMPR--PDNC 480 Query: 2579 PAAVRPLIEQCCALQPEKRPDFWQLVKTLEKIQSVM 2686 P + ++ +C +PE+RP T E IQSV+ Sbjct: 481 PEELYNIMIRCWKNRPEERP-------TFEYIQSVL 509
>Q07407:FGFR1_DROME Fibroblast growth factor receptor homolog 1 precursor - Drosophila| melanogaster (Fruit fly) Length = 729 Score = 117 bits (293), Expect = 3e-25 Identities = 75/292 (25%), Positives = 139/292 (47%), Gaps = 23/292 (7%) Frame = +2 Query: 1868 DWKLDKAKLLVGHSFASGAHSRLYRGLYDDKPVAIKFIRRPHEDPGGIMAAKLDKQYNTE 2047 +W+L ++ L++G + GA R+ ++ VA+K ++ H D + E Sbjct: 408 NWELPRSHLVLGATLGEGAFGRVVMAEVNNAIVAVKMVKEGHTDDDIASLVR-------E 460 Query: 2048 INALSHL-YHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLH----------------- 2173 + + + H N+I L+ Y+I E P G+L+ +L+ Sbjct: 461 MEVMKIIGRHINIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNRPFGRDQDRDSSQPP 520 Query: 2174 -NPEHRPLPLERTISIALEIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIAXX 2350 +P + + I A +IARG++Y+ S+ +HRD+ N+L +++ +KIADFG+A Sbjct: 521 PSPPAHVITEKDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARD 580 Query: 2351 XXXXXXXXXXXG---TYRWMAPEMIKRKPYNRKVDVYSFGLLLWEMVT-GRIPFENLSPV 2518 +WMAPE ++ K Y+ K DV+S+G+LLWE++T G+ P+ + Sbjct: 581 IQSTDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSA 640 Query: 2519 QVAYAVATDKLKPMDPQDYCPAAVRPLIEQCCALQPEKRPDFWQLVKTLEKI 2674 + Y + M+ C + L+ QC + RP F ++V+ ++K+ Sbjct: 641 EELYTYLMSGQR-MEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYMDKL 691
>P16277:BLK_MOUSE Tyrosine-protein kinase BLK - Mus musculus (Mouse)| Length = 499 Score = 117 bits (293), Expect = 3e-25 Identities = 80/270 (29%), Positives = 127/270 (47%), Gaps = 3/270 (1%) Frame = +2 Query: 1868 DWKLDKAKLLVGHSFASGAHSRLYRGLY-DDKPVAIKFIRRPHEDPGGIMAAKLDKQYNT 2044 +W++ + L + SG ++ G Y ++ VAIK ++ P + Sbjct: 227 EWEIPRQSLKLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLG--------- 277 Query: 2045 EINALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIAL 2224 E N + L H+ +++L A P+Y I+TE + G L +L E L L R I ++ Sbjct: 278 EANVMKTLQHERLVRLYAVVTREPIY-IVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSA 336 Query: 2225 EIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIAXXXXXXXXXXXXXG-TYRWM 2401 ++A G+ Y+ +HRD++ NIL E KIADFG+A +W Sbjct: 337 QVAEGMAYIERMNSIHRDLRAANILVSETLCCKIADFGLARIIDSEYTAQEGAKFPIKWT 396 Query: 2402 APEMIKRKPYNRKVDVYSFGLLLWEMVT-GRIPFENLSPVQVAYAVATDKLKPMDPQDYC 2578 APE I + K DV+SFG+LL +VT GR+P+ +S +V ++ P P+ Sbjct: 397 APEAIHFGVFTIKADVWSFGVLLMVIVTYGRVPYPGMSNPEVIRSLEHGYRMPC-PETCP 455 Query: 2579 PAAVRPLIEQCCALQPEKRPDFWQLVKTLE 2668 P +I +C +PE+RP F L LE Sbjct: 456 PELYNDIITECWRGRPEERPTFEFLQSVLE 485
>Q95M30:HCK_MACFA Tyrosine-protein kinase HCK - Macaca fascicularis (Crab eating| macaque) (Cynomolgus monkey) Length = 504 Score = 117 bits (292), Expect = 4e-25 Identities = 83/276 (30%), Positives = 135/276 (48%), Gaps = 4/276 (1%) Frame = +2 Query: 1871 WKLDKAKLLVGHSFASGAHSRLYRGLYDDKP-VAIKFIRRPHEDPGGIMAAKLDKQYNTE 2047 W++ + L + +G ++ Y+ VA+K ++ PG + + + E Sbjct: 233 WEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMK-----PGSMSV----EAFLAE 283 Query: 2048 INALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIALE 2227 N + L H ++KL A P+Y IITE + GSL +L + E PL + I + + Sbjct: 284 ANLMKTLQHDKLVKLHAVVTKEPIY-IITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQ 342 Query: 2228 IARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIAXXXXXXXXXXXXXGTY--RWM 2401 IA G+ ++ + +HRD++ NIL + KIADFG+A + +W Sbjct: 343 IAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARIIEDNEYTAREGAKFPIKWT 402 Query: 2402 APEMIKRKPYNRKVDVYSFGLLLWEMVT-GRIPFENLSPVQVAYAVATDKLKPMDPQDYC 2578 APE I K DV+SFG+LL E+VT GRIP+ +S +V A+ ++ M + C Sbjct: 403 APEAINFGSSTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRAL--ERGYRMPRPENC 460 Query: 2579 PAAVRPLIEQCCALQPEKRPDFWQLVKTLEKIQSVM 2686 P + ++ +C +PE+RP T E IQSV+ Sbjct: 461 PEELYNIMMRCWKNRPEERP-------TFEYIQSVL 489
>P13406:FYN_XENLA Proto-oncogene tyrosine-protein kinase Fyn - Xenopus laevis (African| clawed frog) Length = 537 Score = 117 bits (292), Expect = 4e-25 Identities = 81/270 (30%), Positives = 129/270 (47%), Gaps = 4/270 (1%) Frame = +2 Query: 1871 WKLDKAKLLVGHSFASGAHSRLYRGLYD-DKPVAIKFIRRPHEDPGGIMAAKLDKQYNTE 2047 W++ + L + +G ++ G ++ + VAIK ++ P + + E Sbjct: 264 WEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSP---------ESFLEE 314 Query: 2048 INALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIALE 2227 + L H +++L A P+Y I+TE + GSL +L + E R L L + +A + Sbjct: 315 AQIMKKLKHDKLVQLYAVVSEEPIY-IVTEYMSKGSLLDFLKDGEGRALKLPNLVDMAAQ 373 Query: 2228 IARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIAXXXXXXXXXXXXXGTY--RWM 2401 +ARG+ Y+ +HRD++ NIL KIADFG+A + +W Sbjct: 374 VARGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWT 433 Query: 2402 APEMIKRKPYNRKVDVYSFGLLLWEMVT-GRIPFENLSPVQVAYAVATDKLKPMDPQDYC 2578 APE + K DV+SFG+LL E+VT GR+P+ ++ +V V P PQD C Sbjct: 434 APEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPC-PQD-C 491 Query: 2579 PAAVRPLIEQCCALQPEKRPDFWQLVKTLE 2668 P ++ L+ C PE+RP F L LE Sbjct: 492 PISLHELMLNCWKKDPEERPTFEYLQGFLE 521
>P00541:FPS_AVISP Tyrosine-protein kinase transforming protein Fps - Avian sarcoma| virus (strain PRCII) Length = 533 Score = 117 bits (292), Expect = 4e-25 Identities = 78/267 (29%), Positives = 127/267 (47%), Gaps = 9/267 (3%) Frame = +2 Query: 1871 WKLDKAKLLVGHSFASGAHSRLYRGLY--DDKPVAIKFIRR---PHEDPGGIMAAKLDKQ 2035 W L+ +L+G G ++ G D+ PVA+K R P + A++ KQ Sbjct: 265 WVLNHEDVLLGERIGRGNFGEVFSGRLRADNTPVAVKSCRETLPPELKAKFLQEARILKQ 324 Query: 2036 YNTEINALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTIS 2215 YN H N+++L+ YI+ EL+ GG S+L + L ++ I Sbjct: 325 YN----------HPNIVRLIGVCTQKQPIYIVMELVQGGDFLSFLRSKGPH-LKMKELIK 373 Query: 2216 IALEIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIAXXXXXXXXXXXXXG--- 2386 + A G+EY+ S+ +HRD+ N L E +KI+DFG++ Sbjct: 374 MMENAAAGMEYLESKHCIHRDLAARNCLVTEKNTLKISDFGMSRQEEDGVYASTGGMKQI 433 Query: 2387 TYRWMAPEMIKRKPYNRKVDVYSFGLLLWEMVT-GRIPFENLSPVQVAYAVATDKLKPMD 2563 +W APE + Y+ + DV+SFG+LLWE + G +P+ NLS Q A+ ++ ++ Sbjct: 434 PVKWTAPEALNYGRYSSESDVWSFGILLWEAFSLGAVPYANLSNQQTREAI--EQGVRLE 491 Query: 2564 PQDYCPAAVRPLIEQCCALQPEKRPDF 2644 P + CP V L+++C P +RP F Sbjct: 492 PPEQCPEDVYRLMQRCWEYDPRRRPSF 518
>P22607:FGFR3_HUMAN Fibroblast growth factor receptor 3 precursor - Homo sapiens (Human)| Length = 806 Score = 117 bits (292), Expect = 4e-25 Identities = 89/334 (26%), Positives = 155/334 (46%), Gaps = 31/334 (9%) Frame = +2 Query: 1799 RVSAVENVRSRTVSMAQAVQSTVD--WKLDKAKLLVGHSFASGAHSRLYR----GLYDD- 1957 R++ + + T++ ++ D W+L +A+L +G G ++ G+ D Sbjct: 439 RIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDR 498 Query: 1958 --KPVAIKFIRRPHEDPGGIMAAKLDKQYNTEINALSHLY----HKNVIKLVATHKCGPV 2119 KPV + ++ +D DK + ++ + + HKN+I L+ G Sbjct: 499 AAKPVTVA-VKMLKDDA-------TDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGP 550 Query: 2120 YYIITELLPGGSLRSYLH--------------NPEHRPLPLERTISIALEIARGLEYVHS 2257 Y++ E G+LR +L P L + +S A ++ARG+EY+ S Sbjct: 551 LYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLAS 610 Query: 2258 QGVVHRDIKPENILFDENFEVKIADFGIAXXXXXXXXXXXXXG---TYRWMAPEMIKRKP 2428 Q +HRD+ N+L E+ +KIADFG+A +WMAPE + + Sbjct: 611 QKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRV 670 Query: 2429 YNRKVDVYSFGLLLWEMVT-GRIPFENLSPVQVAYAVATDKLKPMDPQDYCPAAVRPLIE 2605 Y + DV+SFG+LLWE+ T G P+ + PV+ + + + + MD C + ++ Sbjct: 671 YTHQSDVWSFGVLLWEIFTLGGSPYPGI-PVEELFKLLKEGHR-MDKPANCTHDLYMIMR 728 Query: 2606 QCCALQPEKRPDFWQLVKTLEKIQSVMSQGGSLD 2707 +C P +RP F QLV+ L+++ +V S LD Sbjct: 729 ECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLD 762
>P00522:ABL_DROME Tyrosine-protein kinase Abl - Drosophila melanogaster (Fruit fly)| Length = 1620 Score = 117 bits (292), Expect = 4e-25 Identities = 74/272 (27%), Positives = 128/272 (47%), Gaps = 5/272 (1%) Frame = +2 Query: 1868 DWKLDKAKLLVGHSFASGAHSRLYRGLYD--DKPVAIKFIRRPHEDPGGIMAAKLDKQYN 2041 +W++ + +++ H G + +Y ++ VA+K ++ ED + K + Sbjct: 363 EWEICRTDIMMKHKLGGGQYGEVYEAVWKRYGNTVAVKTLK---EDTMAL------KDFL 413 Query: 2042 TEINALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIA 2221 E + + H N+++L+ P +YIITE + G+L +L + L + +A Sbjct: 414 EEAAIMKEMKHPNLVQLIGVCTREPPFYIITEFMSHGNLLDFLRSAGRETLDAVALLYMA 473 Query: 2222 LEIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIAXXXXXXXXXXXXXGTY--R 2395 +IA G+ Y+ S+ +HRD+ N L +N VK+ADFG+A + + Sbjct: 474 TQIASGMSYLESRNYIHRDLAARNCLVGDNKLVKVADFGLARLMRDDTYTAHAGAKFPIK 533 Query: 2396 WMAPEMIKRKPYNRKVDVYSFGLLLWEMVT-GRIPFENLSPVQVAYAVATDKLKPMDPQD 2572 W APE + ++ K DV++FG+LLWE+ T G P+ + V + + DK M+ Sbjct: 534 WTAPEGLAYNKFSTKSDVWAFGVLLWEIATYGMSPYPAIDLTDVYHKL--DKGYRMERPP 591 Query: 2573 YCPAAVRPLIEQCCALQPEKRPDFWQLVKTLE 2668 CP V L+ QC RP F + LE Sbjct: 592 GCPPEVYDLMRQCWQWDATDRPTFKSIHHALE 623
>P14085:SRC_AVIST Tyrosine-protein kinase transforming protein Src - Avian sarcoma| virus (strain S2) Length = 557 Score = 116 bits (291), Expect = 5e-25 Identities = 86/320 (26%), Positives = 145/320 (45%), Gaps = 4/320 (1%) Frame = +2 Query: 1742 SSQKDSSWTRRYFDNVGRRRVSAVENVRSRTVSMAQAVQSTVDWKLDKAKLLVGHSFASG 1921 S Q+ ++ ++ D + R + + +T +A+ W++ + L + G Sbjct: 222 SLQQLVAYYSKHADGLCHRLTNVCPTSKPQTQGLAKDA-----WEIPRESLRLEVKLGQG 276 Query: 1922 AHSRLYRGLYDDKP-VAIKFIRRPHEDPGGIMAAKLDKQYNTEINALSHLYHKNVIKLVA 2098 ++ G ++ VAIK ++ P + E + L H+ +++L A Sbjct: 277 CFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQ---------EAQVMKKLRHEKLVQLYA 327 Query: 2099 THKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIALEIARGLEYVHSQGVVHRD 2278 P+Y I+TE + GSL +L + L L + + +A +IA G+ YV VHRD Sbjct: 328 VVSEEPIY-IVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERMNYVHRD 386 Query: 2279 IKPENILFDENFEVKIADFGIAXXXXXXXXXXXXXGTY--RWMAPEMIKRKPYNRKVDVY 2452 ++ NIL EN K+ADFG+A + +W APE + K DV+ Sbjct: 387 LRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVW 446 Query: 2453 SFGLLLWEMVT-GRIPFENLSPVQVAYAVATDKLKPMDPQDYCPAAVRPLIEQCCALQPE 2629 SFG+LL E+ T GR+P+ + +V V P P+ CP ++ L+ QC PE Sbjct: 447 SFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPE--CPESLHDLMCQCWRKDPE 504 Query: 2630 KRPDFWQLVKTLEKIQSVMS 2689 +RP F L LE +++ Sbjct: 505 ERPTFEYLQAFLEDYLGILA 524
>P35465:PAK1_RAT Serine/threonine-protein kinase PAK 1 - Rattus norvegicus (Rat)| Length = 544 Score = 116 bits (291), Expect = 5e-25 Identities = 107/431 (24%), Positives = 192/431 (44%), Gaps = 11/431 (2%) Frame = +2 Query: 1400 KSEKSKAPRARSLV-------KSPSSMMLLSYLNKAYPNQGSSVQNADGSLH-KPRSKSP 1555 KSE+ K P+A V K+ +S +S+ +K+ + SS +L+ K S++P Sbjct: 114 KSEQKKNPQAVLDVLEFYNSKKTSNSQKYMSFTDKSAEDYNSS-----NTLNVKTVSETP 168 Query: 1556 LPSVVPSDTFREARASSQRFTSPPPKRVGSDKSVYGKSLGREQCDMAASPDWCSTPVVFG 1735 V D + A+ +P P+ KSVY +S+ E + + D ++P+ Sbjct: 169 AVPPVSEDEDDDDDATPPPVIAPRPEHT---KSVYTRSV-IEPLPVTPTRDVATSPISPT 224 Query: 1736 EHSSQKDSSWTRRYFDNVGRRRVSAVENVRSRTVSMAQAVQSTVDWKLDKAKLLVGHSFA 1915 E+++ + TR + ++S E + + ++S V K K Sbjct: 225 ENNTTPPDALTRNTEKQKKKPKMSDEE--------ILEKLRSIVSVGDPKKKYTRFEKIG 276 Query: 1916 SGAHSRLYRGL--YDDKPVAIKFIRRPHEDPGGIMAAKLDKQYNTEINALSHLYHKNVIK 2089 GA +Y + + VAIK + + ++ EI + + N++ Sbjct: 277 QGASGTVYTAMDVATGQEVAIKQMNLQQQPKKELII--------NEILVMRENKNPNIVN 328 Query: 2090 LVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIALEIARGLEYVHSQGVV 2269 + ++ G +++ E L GGSL + + + ++ E + LE++HS V+ Sbjct: 329 YLDSYLVGDELWVVMEYLAGGSLTDVV---TETCMDEGQIAAVCRECLQALEFLHSNQVI 385 Query: 2270 HRDIKPENILFDENFEVKIADFGI-AXXXXXXXXXXXXXGTYRWMAPEMIKRKPYNRKVD 2446 HRDIK +NIL + VK+ DFG A GT WMAPE++ RK Y KVD Sbjct: 386 HRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVD 445 Query: 2447 VYSFGLLLWEMVTGRIPFENLSPVQVAYAVATDKLKPMDPQDYCPAAVRPLIEQCCALQP 2626 ++S G++ EM+ G P+ N +P++ Y +AT+ + + A R + +C + Sbjct: 446 IWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLEMDV 505 Query: 2627 EKRPDFWQLVK 2659 EKR +L++ Sbjct: 506 EKRGSAKELLQ 516
>P53669:LIMK1_RAT LIM domain kinase 1 - Rattus norvegicus (Rat)| Length = 647 Score = 116 bits (291), Expect = 5e-25 Identities = 76/257 (29%), Positives = 121/257 (47%), Gaps = 24/257 (9%) Frame = +2 Query: 1979 IRRPHEDPGGIMAAK--------LDKQYNTEINALSHLYHKNVIKLVATHKCGPVYYIIT 2134 I+ H + G +M K + + E+ + L H NV+K + IT Sbjct: 354 IKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGVLYKDKRLNFIT 413 Query: 2135 ELLPGGSLRSYLHNPEHRPLPLERTISIALEIARGLEYVHSQGVVHRDIKPENILFDENF 2314 E + GG+LR + + + + P + +S A +IA G+ Y+HS ++HRD+ N L EN Sbjct: 414 EYIKGGTLRGIIKSMDSQ-YPWSQRVSFAKDIASGMAYLHSMNIIHRDLNSHNCLVRENR 472 Query: 2315 EVKIADFGIA---------------XXXXXXXXXXXXXGTYRWMAPEMIKRKPYNRKVDV 2449 V +ADFG+A G WMAPEMI + Y+ KVDV Sbjct: 473 NVVVADFGLARLMIDEKGQSEDLRSLKKPDRKKRYTVVGNPYWMAPEMINGRSYDEKVDV 532 Query: 2450 YSFGLLLWEMVTGRIPFE-NLSPVQVAYAVATDKLKPMDPQDYCPAAVRPLIEQCCALQP 2626 +SFG++L E++ GR+ + + P + + + CP + P+ +CC L P Sbjct: 533 FSFGIVLCEII-GRVNADPDYLPRTMDFGLNVRGFLDRYCPPNCPPSFFPITVRCCDLDP 591 Query: 2627 EKRPDFWQLVKTLEKIQ 2677 EKRP F +L + LE ++ Sbjct: 592 EKRPSFVKLEQWLETLR 608
>P21804:FGFR1_CHICK Basic fibroblast growth factor receptor 1 precursor - Gallus gallus| (Chicken) Length = 819 Score = 116 bits (291), Expect = 5e-25 Identities = 92/311 (29%), Positives = 151/311 (48%), Gaps = 32/311 (10%) Frame = +2 Query: 1871 WKLDKAKLLVGHSFASGAHSRLYR----GLYDDKP-----VAIKFIRRPHEDPGGIMAAK 2023 W+L + +L++G G ++ GL DKP VA+K ++ + Sbjct: 469 WELPRDRLILGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLK----------SDA 518 Query: 2024 LDKQYNTEINALSHLY----HKNVIKLV-ATHKCGPVYYIITELLPGGSLRSYL------ 2170 +K + I+ + + HKN+I L+ A + GP+Y +I E G+LR YL Sbjct: 519 TEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLY-VIVEYASKGNLREYLQARRPP 577 Query: 2171 -----HNPEHRP---LPLERTISIALEIARGLEYVHSQGVVHRDIKPENILFDENFEVKI 2326 +NP P L + +S A ++ARG+EY+ S+ +HRD+ N+L E+ +KI Sbjct: 578 GMEYCYNPTRIPEEQLSFKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKI 637 Query: 2327 ADFGIAXXXXXXXXXXXXXG---TYRWMAPEMIKRKPYNRKVDVYSFGLLLWEMVT-GRI 2494 ADFG+A +WMAPE + + Y + DV+SFG+LLWE+ T G Sbjct: 638 ADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGS 697 Query: 2495 PFENLSPVQVAYAVATDKLKPMDPQDYCPAAVRPLIEQCCALQPEKRPDFWQLVKTLEKI 2674 P+ + PV+ + + + + MD C + ++ C P +RP F QLV+ L++I Sbjct: 698 PYPGV-PVEELFKLLKEGHR-MDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRI 755 Query: 2675 QSVMSQGGSLD 2707 ++ S LD Sbjct: 756 VAMTSNQEYLD 766
>P00519:ABL1_HUMAN Proto-oncogene tyrosine-protein kinase ABL1 - Homo sapiens (Human)| Length = 1130 Score = 116 bits (291), Expect = 5e-25 Identities = 75/302 (24%), Positives = 141/302 (46%), Gaps = 5/302 (1%) Frame = +2 Query: 1871 WKLDKAKLLVGHSFASGAHSRLYRGLYD--DKPVAIKFIRRPHEDPGGIMAAKLDKQYNT 2044 W++++ + + H G + +Y G++ VA+K ++ ED + +++ Sbjct: 235 WEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLK---EDTMEV------EEFLK 285 Query: 2045 EINALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIAL 2224 E + + H N+++L+ P +YIITE + G+L YL + + + +A Sbjct: 286 EAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMAT 345 Query: 2225 EIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIAXXXXXXXXXXXXXGTY--RW 2398 +I+ +EY+ + +HRD+ N L EN VK+ADFG++ + +W Sbjct: 346 QISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKW 405 Query: 2399 MAPEMIKRKPYNRKVDVYSFGLLLWEMVT-GRIPFENLSPVQVAYAVATDKLKPMDPQDY 2575 APE + ++ K DV++FG+LLWE+ T G P+ + QV + D M+ + Sbjct: 406 TAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKD--YRMERPEG 463 Query: 2576 CPAAVRPLIEQCCALQPEKRPDFWQLVKTLEKIQSVMSQGGSLDTLRSSGHKKGLKHWIQ 2755 CP V L+ C P RP F ++ + E ++ + D + K+G++ + Sbjct: 464 CPEKVYELMRACWQWNPSDRPSFAEIHQAFE---TMFQESSISDEVEKELGKQGVRGAVS 520 Query: 2756 KL 2761 L Sbjct: 521 TL 522
>P42688:SRK2_SPOLA Tyrosine-protein kinase SRK2 - Spongilla lacustris (Freshwater| sponge) Length = 362 Score = 116 bits (290), Expect = 6e-25 Identities = 82/270 (30%), Positives = 128/270 (47%), Gaps = 4/270 (1%) Frame = +2 Query: 1871 WKLDKAKLLVGHSFASGAHSRLYRGLYDDK-PVAIKFIRRPHEDPGGIMAAKLDKQYNTE 2047 W++ + + + +G +Y+GL+++ PVA+K ++ P +A E Sbjct: 88 WEISRDSITLIRKLGAGQFGEVYQGLWNNSTPVAVKTLKAGTMQPAAFLA---------E 138 Query: 2048 INALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIALE 2227 + L H +I+L A G YIITEL+ GSL YL E L L + I +A + Sbjct: 139 AQIMKKLRHPKLIQLYAVCTQGEPVYIITELMSKGSLLDYLQG-EAGALKLPQLIDMAAQ 197 Query: 2228 IARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIAXXXXXXXXXXXXXGTY--RWM 2401 +A G+ Y+ +HRD+ NIL +N K+ADFG+A + +W Sbjct: 198 VAAGMAYLELHNYIHRDLAARNILVGDNNICKVADFGLARLIVSDDYNATEGAKFPIKWT 257 Query: 2402 APEMIKRKPYNRKVDVYSFGLLLWEMVT-GRIPFENLSPVQVAYAVATDKLKPMDPQDYC 2578 APE ++ K DV+SFG+L+ E+VT GRIP+ +S +V + DK M Sbjct: 258 APEAALFNRFSIKSDVWSFGILITELVTYGRIPYPGMSNAEVLQNL--DKGYRMPCPVTT 315 Query: 2579 PAAVRPLIEQCCALQPEKRPDFWQLVKTLE 2668 P ++ ++ C P RP F L LE Sbjct: 316 PESLYQIMLDCWKRNPADRPTFEALQWRLE 345
>P14084:SRC_AVISS Tyrosine-protein kinase transforming protein Src - Avian sarcoma| virus (strain S1) Length = 568 Score = 116 bits (290), Expect = 6e-25 Identities = 86/313 (27%), Positives = 142/313 (45%), Gaps = 4/313 (1%) Frame = +2 Query: 1742 SSQKDSSWTRRYFDNVGRRRVSAVENVRSRTVSMAQAVQSTVDWKLDKAKLLVGHSFASG 1921 S Q+ ++ ++ D + R + + +T +A+ W++ + L + G Sbjct: 222 SLQQLVAYYSKHADGLCHRLTNVCPTSKPQTQGLAKDA-----WEIPRESLRLEVKLGQG 276 Query: 1922 AHSRLYRGLYDDKP-VAIKFIRRPHEDPGGIMAAKLDKQYNTEINALSHLYHKNVIKLVA 2098 ++ G ++ VAIK ++ P + E + L H+ +++L A Sbjct: 277 CFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQ---------EAQVMKKLRHEKLVRLYA 327 Query: 2099 THKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIALEIARGLEYVHSQGVVHRD 2278 P+Y I+TE + GSL +L + L L + + +A +IA G+ YV VHRD Sbjct: 328 VVSEEPIY-IVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERMNYVHRD 386 Query: 2279 IKPENILFDENFEVKIADFGIAXXXXXXXXXXXXXGTY--RWMAPEMIKRKPYNRKVDVY 2452 ++ NIL EN K+ADFG+A + +W APE + K DV+ Sbjct: 387 LRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVW 446 Query: 2453 SFGLLLWEMVT-GRIPFENLSPVQVAYAVATDKLKPMDPQDYCPAAVRPLIEQCCALQPE 2629 SFG+LL E+ T GR+P+ + +V V P P+ CP ++ L+ QC PE Sbjct: 447 SFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPE--CPESLHDLMCQCWRKDPE 504 Query: 2630 KRPDFWQLVKTLE 2668 +RP F L LE Sbjct: 505 ERPTFEYLQAFLE 517
>P09560:RAF1_XENLA RAF proto-oncogene serine/threonine-protein kinase - Xenopus laevis| (African clawed frog) Length = 638 Score = 116 bits (290), Expect = 6e-25 Identities = 99/417 (23%), Positives = 188/417 (45%), Gaps = 29/417 (6%) Frame = +2 Query: 1514 NADGSLHKPRSKSPLPSVVP---SDTFREARASSQRFTSPPPKRVGSDKSVYGKSLGREQ 1684 N +G H LPS+ ++ R +S QR+++P P + V SL + Q Sbjct: 200 NIEGGSHT------LPSLTMRRIGESVRIPVSSQQRYSTPHPFSFSTPSPVSECSLSQRQ 253 Query: 1685 ----------------CDMAASPDWCSTPVVFGEHSSQKDSSWTRRYFDNVGRRRVSAVE 1816 D D + G ++ + W+ R +A Sbjct: 254 RSTSTPNVHMVSTTMAVDSRVIEDALRSHSESGSPNNLSPTGWSNAKAPAPTHREKAASS 313 Query: 1817 NVRSRTVSMAQAVQ-STVDWKLDKAKLLVGHSFASGAHSRLYRGLYDDKPVAIKFIRRPH 1993 + + A+ + S+ W++ +++++ SG+ +Y+G + VA+K ++ Sbjct: 314 TGQEKNKIRARGQRDSSYYWEIIASEVMLSSRIGSGSFGTVYKGKWHGD-VAVKILKVTD 372 Query: 1994 EDPGGIMAAKLDKQYNTEINALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLH 2173 P + A + E+ L H N++ L + I+T+ G SL +LH Sbjct: 373 PTPEQLQA------FRNEVAVLRKTRHVNIL-LFMGYMTKDNLAIVTQWCEGSSLYYHLH 425 Query: 2174 NPEHRPLPLERTISIALEIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIA--- 2344 + + + + I IA + A+G++Y+H++ ++HRD+K NI E VKI DFG+A Sbjct: 426 VLDTK-FQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVK 484 Query: 2345 XXXXXXXXXXXXXGTYRWMAPEMIK---RKPYNRKVDVYSFGLLLWEMVTGRIPFENL-S 2512 G+ WMAPE+I+ P++ + DVYS+G++L+E++TG +P+ ++ Sbjct: 485 TRWSGSQQVEQLTGSILWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHIRD 544 Query: 2513 PVQVAYAVATDKLKPMDPQDY--CPAAVRPLIEQCCALQPEKRPDFWQLVKTLEKIQ 2677 Q+ + V + P + Y CP A++ L+ ++RP F Q++ ++E +Q Sbjct: 545 RDQIIFLVGRGGVVPDLSKLYKNCPKAMKRLVADSIKKLRDERPLFPQILSSIELLQ 601
>P00521:ABL_MLVAB Tyrosine-protein kinase transforming protein Abl - Abelson murine| leukemia virus Length = 746 Score = 116 bits (290), Expect = 6e-25 Identities = 71/271 (26%), Positives = 129/271 (47%), Gaps = 5/271 (1%) Frame = +2 Query: 1871 WKLDKAKLLVGHSFASGAHSRLYRGLYD--DKPVAIKFIRRPHEDPGGIMAAKLDKQYNT 2044 W++++ + + H G + +Y G++ VA+K ++ ED + +++ Sbjct: 121 WEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLK---EDTMEV------EEFLK 171 Query: 2045 EINALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIAL 2224 E + + H N+++L+ P +YIITE + G+L YL + + + +A Sbjct: 172 EAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVSAVVLLYMAT 231 Query: 2225 EIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIAXXXXXXXXXXXXXGTY--RW 2398 +I+ +EY+ + +HRD+ N L EN VK+ADFG++ + +W Sbjct: 232 QISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKW 291 Query: 2399 MAPEMIKRKPYNRKVDVYSFGLLLWEMVT-GRIPFENLSPVQVAYAVATDKLKPMDPQDY 2575 APE + ++ K DV++FG+LLWE+ T G P+ + QV + D M+ + Sbjct: 292 TAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKD--YRMERPEG 349 Query: 2576 CPAAVRPLIEQCCALQPEKRPDFWQLVKTLE 2668 CP V L+ C P RP F ++ + E Sbjct: 350 CPEKVYELMRACWQWNPSDRPSFAEIHQAFE 380
>P42684:ABL2_HUMAN Tyrosine-protein kinase ABL2 - Homo sapiens (Human)| Length = 1182 Score = 116 bits (290), Expect = 6e-25 Identities = 71/271 (26%), Positives = 129/271 (47%), Gaps = 5/271 (1%) Frame = +2 Query: 1871 WKLDKAKLLVGHSFASGAHSRLYRGLYD--DKPVAIKFIRRPHEDPGGIMAAKLDKQYNT 2044 W++++ + + H G + +Y G++ VA+K ++ ED + +++ Sbjct: 281 WEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLK---EDTMEV------EEFLK 331 Query: 2045 EINALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIAL 2224 E + + H N+++L+ P +YI+TE +P G+L YL + + +A Sbjct: 332 EAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMAT 391 Query: 2225 EIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIAXXXXXXXXXXXXXGTY--RW 2398 +I+ +EY+ + +HRD+ N L EN VK+ADFG++ + +W Sbjct: 392 QISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKW 451 Query: 2399 MAPEMIKRKPYNRKVDVYSFGLLLWEMVT-GRIPFENLSPVQVAYAVATDKLKPMDPQDY 2575 APE + ++ K DV++FG+LLWE+ T G P+ + QV + +K M+ + Sbjct: 452 TAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLL--EKGYRMEQPEG 509 Query: 2576 CPAAVRPLIEQCCALQPEKRPDFWQLVKTLE 2668 CP V L+ C P RP F + + E Sbjct: 510 CPPKVYELMRACWKWSPADRPSFAETHQAFE 540
>P00520:ABL1_MOUSE Proto-oncogene tyrosine-protein kinase ABL1 - Mus musculus (Mouse)| Length = 1123 Score = 116 bits (290), Expect = 6e-25 Identities = 71/271 (26%), Positives = 129/271 (47%), Gaps = 5/271 (1%) Frame = +2 Query: 1871 WKLDKAKLLVGHSFASGAHSRLYRGLYD--DKPVAIKFIRRPHEDPGGIMAAKLDKQYNT 2044 W++++ + + H G + +Y G++ VA+K ++ ED + +++ Sbjct: 235 WEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLK---EDTMEV------EEFLK 285 Query: 2045 EINALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIAL 2224 E + + H N+++L+ P +YIITE + G+L YL + + + +A Sbjct: 286 EAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVSAVVLLYMAT 345 Query: 2225 EIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIAXXXXXXXXXXXXXGTY--RW 2398 +I+ +EY+ + +HRD+ N L EN VK+ADFG++ + +W Sbjct: 346 QISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKW 405 Query: 2399 MAPEMIKRKPYNRKVDVYSFGLLLWEMVT-GRIPFENLSPVQVAYAVATDKLKPMDPQDY 2575 APE + ++ K DV++FG+LLWE+ T G P+ + QV + D M+ + Sbjct: 406 TAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKD--YRMERPEG 463 Query: 2576 CPAAVRPLIEQCCALQPEKRPDFWQLVKTLE 2668 CP V L+ C P RP F ++ + E Sbjct: 464 CPEKVYELMRACWQWNPSDRPSFAEIHQAFE 494
>P09324:YES_CHICK Tyrosine-protein kinase Yes - Gallus gallus (Chicken)| Length = 541 Score = 115 bits (289), Expect = 8e-25 Identities = 88/313 (28%), Positives = 145/313 (46%), Gaps = 4/313 (1%) Frame = +2 Query: 1742 SSQKDSSWTRRYFDNVGRRRVSAVENVRSRTVSMAQAVQSTVDWKLDKAKLLVGHSFASG 1921 S QK R + D + + + V+ +T +A+ W++ + L + G Sbjct: 230 SLQKLVKHYREHADGLCHKLTTVCPTVKPQTQGLAKDA-----WEIPRESLRLEVKLGQG 284 Query: 1922 AHSRLYRGLYDDKP-VAIKFIRRPHEDPGGIMAAKLDKQYNTEINALSHLYHKNVIKLVA 2098 ++ G ++ VAIK ++ PG +M + + E + L H ++ L A Sbjct: 285 CFGEVWMGTWNGTTKVAIKTLK-----PGTMMP----EAFLQEAQIMKKLRHDKLVPLYA 335 Query: 2099 THKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIALEIARGLEYVHSQGVVHRD 2278 P+Y I+TE + GSL +L E + L L + + +A +IA G+ Y+ +HRD Sbjct: 336 VVSEEPIY-IVTEFMTKGSLLDFLKEGEGKFLKLPQLVDMAAQIADGMAYIERMNYIHRD 394 Query: 2279 IKPENILFDENFEVKIADFGIAXXXXXXXXXXXXXGTY--RWMAPEMIKRKPYNRKVDVY 2452 ++ NIL +N KIADFG+A + +W APE + K DV+ Sbjct: 395 LRAANILVGDNLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVW 454 Query: 2453 SFGLLLWEMVT-GRIPFENLSPVQVAYAVATDKLKPMDPQDYCPAAVRPLIEQCCALQPE 2629 SFG+LL E+VT GR+P+ + +V V P PQ CP ++ L++ C P+ Sbjct: 455 SFGILLTELVTKGRVPYPGMVNREVLEQVERGYRMPC-PQG-CPESLHELMKLCWKKDPD 512 Query: 2630 KRPDFWQLVKTLE 2668 +RP F + LE Sbjct: 513 ERPTFEYIQSFLE 525
>P00527:YES_AVISY Tyrosine-protein kinase transforming protein YES - Avian sarcoma| virus (strain Y73) Length = 528 Score = 115 bits (289), Expect = 8e-25 Identities = 85/313 (27%), Positives = 144/313 (46%), Gaps = 4/313 (1%) Frame = +2 Query: 1742 SSQKDSSWTRRYFDNVGRRRVSAVENVRSRTVSMAQAVQSTVDWKLDKAKLLVGHSFASG 1921 S QK +R + D + + + V+ +T +A+ W++ + L + G Sbjct: 222 SLQKLVKHSREHADGLCHKLTTVCPTVKPQTQGLAKDA-----WEIPRESLRLEVKLGQG 276 Query: 1922 AHSRLYRGLYDDKP-VAIKFIRRPHEDPGGIMAAKLDKQYNTEINALSHLYHKNVIKLVA 2098 ++ G ++ VAIK ++ + + + + E + L H ++ L A Sbjct: 277 CFGEVWMGTWNGTTKVAIKTLK---------LGTMMPEAFLQEAQIMKKLRHDKLVPLYA 327 Query: 2099 THKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIALEIARGLEYVHSQGVVHRD 2278 P+Y I+TE + GSL +L E + L L + + +A +IA G+ Y+ +HRD Sbjct: 328 VVSEEPIY-IVTEFMTKGSLLDFLKEGEGKFLKLPQLVDMAAQIADGMAYIERMNYIHRD 386 Query: 2279 IKPENILFDENFEVKIADFGIAXXXXXXXXXXXXXGTY--RWMAPEMIKRKPYNRKVDVY 2452 ++ NIL +N KIADFG+A + +W APE + K DV+ Sbjct: 387 LRAANILVGDNLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVW 446 Query: 2453 SFGLLLWEMVT-GRIPFENLSPVQVAYAVATDKLKPMDPQDYCPAAVRPLIEQCCALQPE 2629 SFG+LL E+VT GR+P+ + +V V P PQ CP ++ L++ C P+ Sbjct: 447 SFGILLTELVTKGRVPYPGMVNREVLEQVERGYRMPC-PQG-CPESLHELMKLCWKKDPD 504 Query: 2630 KRPDFWQLVKTLE 2668 +RP F + LE Sbjct: 505 ERPTFEYIQSFLE 517
>Q2VWQ3:STE20_PENMA Serine/threonine-protein kinase pakA - Penicillium marneffei| Length = 642 Score = 115 bits (289), Expect = 8e-25 Identities = 64/206 (31%), Positives = 105/206 (50%), Gaps = 1/206 (0%) Frame = +2 Query: 2045 EINALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIAL 2224 EI + HKN++ + ++ G +++ E + GGSL + + + ++ Sbjct: 406 EILVMKDSKHKNIVNFLDSYLHGLDLWVVMEYMEGGSLTDVV---TFNIMSEGQIAAVCR 462 Query: 2225 EIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGI-AXXXXXXXXXXXXXGTYRWM 2401 E GL+++HS+GV+HRDIK +NIL + E+K+ DFG A GT WM Sbjct: 463 ETLSGLQHLHSKGVIHRDIKSDNILLSMDGEIKLTDFGFCAQINDSQNKRNTMVGTPYWM 522 Query: 2402 APEMIKRKPYNRKVDVYSFGLLLWEMVTGRIPFENLSPVQVAYAVATDKLKPMDPQDYCP 2581 APE++ RK Y RKVD++S G++ EM+ G P+ SP++ Y +AT+ + + Sbjct: 523 APEVVTRKEYGRKVDIWSLGIMAIEMIEGEPPYLTESPLRALYLIATNGTPKIKDEQNLS 582 Query: 2582 AAVRPLIEQCCALQPEKRPDFWQLVK 2659 R + + PEKR L+K Sbjct: 583 PVFRDFLHLALRVDPEKRASAHDLLK 608
>Q2ULU3:STE20_ASPOR Serine/threonine-protein kinase ste20 - Aspergillus oryzae| Length = 848 Score = 115 bits (289), Expect = 8e-25 Identities = 83/291 (28%), Positives = 137/291 (47%), Gaps = 2/291 (0%) Frame = +2 Query: 1793 RRRVSAVENVRSRTVSMAQAVQST-VDWKLDKAKLLVGHSFASGAHSRLYRGLYDDKPVA 1969 R R S ++RSR V++ T + + L+K +G + G + + G VA Sbjct: 541 RARQSNAMDIRSRLVAICTPGDPTKMYYNLNK----IGQGASGGVFTAYHNGT--GSCVA 594 Query: 1970 IKFIRRPHEDPGGIMAAKLDKQYNTEINALSHLYHKNVIKLVATHKCGPVYYIITELLPG 2149 IK + + K D N EI + HKN++ + ++ G +++ E + G Sbjct: 595 IKQMNLD-------LQPKKDLIIN-EIIVMKDSKHKNIVNFLDSYLHGLDLWVVMEYMEG 646 Query: 2150 GSLRSYLHNPEHRPLPLERTISIALEIARGLEYVHSQGVVHRDIKPENILFDENFEVKIA 2329 GSL + + + ++ E GL+++HS+GV+HRDIK +NIL + +K+ Sbjct: 647 GSLTDVV---TFNIMSEGQIAAVCRETLNGLQHLHSKGVIHRDIKSDNILLSLDGNIKLT 703 Query: 2330 DFGI-AXXXXXXXXXXXXXGTYRWMAPEMIKRKPYNRKVDVYSFGLLLWEMVTGRIPFEN 2506 DFG A GT WMAPE++ RK Y RKVD++S G++ EM+ G P+ Sbjct: 704 DFGFCAQINDSHNKRNTMVGTPYWMAPEVVTRKEYGRKVDIWSLGIMAIEMIEGEPPYLT 763 Query: 2507 LSPVQVAYAVATDKLKPMDPQDYCPAAVRPLIEQCCALQPEKRPDFWQLVK 2659 SP++ Y +AT+ + + R + + PEKR L+K Sbjct: 764 ESPLRALYLIATNGTPTIKDEQSLTPVFRDFLHLALKVDPEKRASAHDLLK 814
>P63185:SRC_RSVSE Tyrosine-protein kinase transforming protein Src - Rous sarcoma virus| (strain Schmidt-Ruppin E) (RSV-SR-E) Length = 526 Score = 115 bits (289), Expect = 8e-25 Identities = 83/305 (27%), Positives = 138/305 (45%), Gaps = 4/305 (1%) Frame = +2 Query: 1742 SSQKDSSWTRRYFDNVGRRRVSAVENVRSRTVSMAQAVQSTVDWKLDKAKLLVGHSFASG 1921 S Q+ ++ ++ D + R + + +T +A+ W++ + L + G Sbjct: 222 SLQQLVAYYSKHADGLCHRLTNVCPTSKPQTQGLAKDA-----WEIPRESLRLEVKLGQG 276 Query: 1922 AHSRLYRGLYDDKP-VAIKFIRRPHEDPGGIMAAKLDKQYNTEINALSHLYHKNVIKLVA 2098 ++ G ++ VAIK ++ P + E + L HK +++L A Sbjct: 277 CFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQ---------EAQVMKKLRHKKLVQLYA 327 Query: 2099 THKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIALEIARGLEYVHSQGVVHRD 2278 P+Y +I E + GSL +L + L L + + +A +IA G+ YV VHRD Sbjct: 328 VVSEEPIYIVI-EYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERMNYVHRD 386 Query: 2279 IKPENILFDENFEVKIADFGIAXXXXXXXXXXXXXGTY--RWMAPEMIKRKPYNRKVDVY 2452 ++ NIL EN K+ADFG+A + +W APE + K DV+ Sbjct: 387 LRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVW 446 Query: 2453 SFGLLLWEMVT-GRIPFENLSPVQVAYAVATDKLKPMDPQDYCPAAVRPLIEQCCALQPE 2629 SFG+LL E+ T GR+P+ + +V V P P+ CP ++ L+ QC PE Sbjct: 447 SFGILLTELTTKGRVPYPGMGNGEVLDRVERGYRMPCPPE--CPESLHDLMSQCWRRDPE 504 Query: 2630 KRPDF 2644 +RP F Sbjct: 505 ERPTF 509
>P05480:SRC_MOUSE Neuronal proto-oncogene tyrosine-protein kinase Src - Mus musculus| (Mouse) Length = 541 Score = 115 bits (289), Expect = 8e-25 Identities = 85/314 (27%), Positives = 144/314 (45%), Gaps = 4/314 (1%) Frame = +2 Query: 1739 HSSQKDSSWTRRYFDNVGRRRVSAVENVRSRTVSMAQAVQSTVDWKLDKAKLLVGHSFAS 1918 +S Q+ ++ ++ D + R + + +T +A+ W++ + L + Sbjct: 229 NSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDA-----WEIPRESLRLEVKLGQ 283 Query: 1919 GAHSRLYRGLYDDKP-VAIKFIRRPHEDPGGIMAAKLDKQYNTEINALSHLYHKNVIKLV 2095 G ++ G ++ VAIK ++ P + E + L H+ +++L Sbjct: 284 GCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQ---------EAQVMKKLRHEKLVQLY 334 Query: 2096 ATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIALEIARGLEYVHSQGVVHR 2275 A P+Y I+TE + GSL +L + L L + + ++ +IA G+ YV VHR Sbjct: 335 AVVSEEPIY-IVTEYMNKGSLLDFLKGETGKYLRLPQLVDMSAQIASGMAYVERMNYVHR 393 Query: 2276 DIKPENILFDENFEVKIADFGIAXXXXXXXXXXXXXGTY--RWMAPEMIKRKPYNRKVDV 2449 D++ NIL EN K+ADFG+A + +W APE + K DV Sbjct: 394 DLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDV 453 Query: 2450 YSFGLLLWEMVT-GRIPFENLSPVQVAYAVATDKLKPMDPQDYCPAAVRPLIEQCCALQP 2626 +SFG+LL E+ T GR+P+ + +V V P P+ CP ++ L+ QC +P Sbjct: 454 WSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPE--CPESLHDLMCQCWRKEP 511 Query: 2627 EKRPDFWQLVKTLE 2668 E+RP F L LE Sbjct: 512 EERPTFEYLQAFLE 525
>P00523:SRC_CHICK Proto-oncogene tyrosine-protein kinase Src - Gallus gallus (Chicken)| Length = 533 Score = 115 bits (289), Expect = 8e-25 Identities = 86/313 (27%), Positives = 142/313 (45%), Gaps = 4/313 (1%) Frame = +2 Query: 1742 SSQKDSSWTRRYFDNVGRRRVSAVENVRSRTVSMAQAVQSTVDWKLDKAKLLVGHSFASG 1921 S Q+ ++ ++ D + R + + +T +A+ W++ + L + G Sbjct: 222 SLQQLVAYYSKHADGLCHRLTNVCPTSKPQTQGLAKDA-----WEIPRESLRLEVKLGQG 276 Query: 1922 AHSRLYRGLYDDKP-VAIKFIRRPHEDPGGIMAAKLDKQYNTEINALSHLYHKNVIKLVA 2098 ++ G ++ VAIK ++ P + E + L H+ +++L A Sbjct: 277 CFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQ---------EAQVMKKLRHEKLVQLYA 327 Query: 2099 THKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIALEIARGLEYVHSQGVVHRD 2278 P+Y I+TE + GSL +L + L L + + +A +IA G+ YV VHRD Sbjct: 328 VVSEEPIY-IVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERMNYVHRD 386 Query: 2279 IKPENILFDENFEVKIADFGIAXXXXXXXXXXXXXGTY--RWMAPEMIKRKPYNRKVDVY 2452 ++ NIL EN K+ADFG+A + +W APE + K DV+ Sbjct: 387 LRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVW 446 Query: 2453 SFGLLLWEMVT-GRIPFENLSPVQVAYAVATDKLKPMDPQDYCPAAVRPLIEQCCALQPE 2629 SFG+LL E+ T GR+P+ + +V V P P+ CP ++ L+ QC PE Sbjct: 447 SFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPE--CPESLHDLMCQCWRKDPE 504 Query: 2630 KRPDFWQLVKTLE 2668 +RP F L LE Sbjct: 505 ERPTFEYLQAFLE 517
>P15054:SRC_AVIS2 Tyrosine-protein kinase transforming protein Src - Avian sarcoma| virus (strain PR2257) Length = 587 Score = 115 bits (289), Expect = 8e-25 Identities = 86/313 (27%), Positives = 142/313 (45%), Gaps = 4/313 (1%) Frame = +2 Query: 1742 SSQKDSSWTRRYFDNVGRRRVSAVENVRSRTVSMAQAVQSTVDWKLDKAKLLVGHSFASG 1921 S Q+ ++ ++ D + R + + +T +A+ W++ + L + G Sbjct: 222 SLQQLVAYYSKHADGLCHRLTNVCPTSKPQTQGLAKDA-----WEIPRESLRLEVKLGQG 276 Query: 1922 AHSRLYRGLYDDKP-VAIKFIRRPHEDPGGIMAAKLDKQYNTEINALSHLYHKNVIKLVA 2098 ++ G ++ VAIK ++ P + E + L H+ +++L A Sbjct: 277 CFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQ---------EAQVMKKLRHEKLVQLYA 327 Query: 2099 THKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIALEIARGLEYVHSQGVVHRD 2278 P+Y I+TE + GSL +L + L L + + +A +IA G+ YV VHRD Sbjct: 328 VVSEEPIY-IVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERMNYVHRD 386 Query: 2279 IKPENILFDENFEVKIADFGIAXXXXXXXXXXXXXGTY--RWMAPEMIKRKPYNRKVDVY 2452 ++ NIL EN K+ADFG+A + +W APE + K DV+ Sbjct: 387 LRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVW 446 Query: 2453 SFGLLLWEMVT-GRIPFENLSPVQVAYAVATDKLKPMDPQDYCPAAVRPLIEQCCALQPE 2629 SFG+LL E+ T GR+P+ + +V V P P+ CP ++ L+ QC PE Sbjct: 447 SFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPE--CPESLHDLMCQCWRKDPE 504 Query: 2630 KRPDFWQLVKTLE 2668 +RP F L LE Sbjct: 505 ERPTFEYLQAFLE 517
>P13116:SRC2_XENLA Tyrosine-protein kinase Src-2 - Xenopus laevis (African clawed frog)| Length = 532 Score = 115 bits (289), Expect = 8e-25 Identities = 86/313 (27%), Positives = 141/313 (45%), Gaps = 4/313 (1%) Frame = +2 Query: 1742 SSQKDSSWTRRYFDNVGRRRVSAVENVRSRTVSMAQAVQSTVDWKLDKAKLLVGHSFASG 1921 S Q+ ++ ++ D + R + + +T +++ W++ + L + G Sbjct: 221 SLQQLVAYYSKHADGLCHRLTAVCPTAKPQTQGLSKDA-----WEIPRDSLRLELKLGQG 275 Query: 1922 AHSRLYRGLYDDKP-VAIKFIRRPHEDPGGIMAAKLDKQYNTEINALSHLYHKNVIKLVA 2098 ++ G ++ VAIK ++ P + E + L H+ +++L A Sbjct: 276 CFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQ---------EAQVMKKLRHEKLVQLYA 326 Query: 2099 THKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIALEIARGLEYVHSQGVVHRD 2278 P+Y I+TE + GSL +L R L L + + +A +IA G+ YV VHRD Sbjct: 327 VVSEEPIY-IVTEYMSKGSLLDFLKGEMGRYLRLPQLVDMAAQIASGMAYVERMNYVHRD 385 Query: 2279 IKPENILFDENFEVKIADFGIAXXXXXXXXXXXXXGTY--RWMAPEMIKRKPYNRKVDVY 2452 ++ NIL EN K+ADFG+A + +W APE + K DV+ Sbjct: 386 LRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVW 445 Query: 2453 SFGLLLWEMVT-GRIPFENLSPVQVAYAVATDKLKPMDPQDYCPAAVRPLIEQCCALQPE 2629 SFG+LL E+ T GR+P+ + +V V P P CP ++ L+ QC PE Sbjct: 446 SFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPD--CPESLHDLMFQCWRKDPE 503 Query: 2630 KRPDFWQLVKTLE 2668 +RP F L LE Sbjct: 504 ERPTFEYLQAFLE 516
>P13115:SRC1_XENLA Tyrosine-protein kinase Src-1 - Xenopus laevis (African clawed frog)| Length = 532 Score = 115 bits (289), Expect = 8e-25 Identities = 86/313 (27%), Positives = 141/313 (45%), Gaps = 4/313 (1%) Frame = +2 Query: 1742 SSQKDSSWTRRYFDNVGRRRVSAVENVRSRTVSMAQAVQSTVDWKLDKAKLLVGHSFASG 1921 S Q+ ++ ++ D + R + + +T +++ W++ + L + G Sbjct: 221 SLQQLVAYYSKHADGLCHRLTTVCPTAKPQTQGLSRDA-----WEIPRDSLRLELKLGQG 275 Query: 1922 AHSRLYRGLYDDKP-VAIKFIRRPHEDPGGIMAAKLDKQYNTEINALSHLYHKNVIKLVA 2098 ++ G ++ VAIK ++ P + E + L H+ +++L A Sbjct: 276 CFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQ---------EAQVMKKLRHEKLVQLYA 326 Query: 2099 THKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIALEIARGLEYVHSQGVVHRD 2278 P+Y I+TE + GSL +L R L L + + +A +IA G+ YV VHRD Sbjct: 327 VVSEEPIY-IVTEYISKGSLLDFLKGEMGRYLRLPQLVDMAAQIASGMAYVERMNYVHRD 385 Query: 2279 IKPENILFDENFEVKIADFGIAXXXXXXXXXXXXXGTY--RWMAPEMIKRKPYNRKVDVY 2452 ++ NIL EN K+ADFG+A + +W APE + K DV+ Sbjct: 386 LRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVW 445 Query: 2453 SFGLLLWEMVT-GRIPFENLSPVQVAYAVATDKLKPMDPQDYCPAAVRPLIEQCCALQPE 2629 SFG+LL E+ T GR+P+ + +V V P P CP ++ L+ QC PE Sbjct: 446 SFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPD--CPESLHDLMFQCWRKDPE 503 Query: 2630 KRPDFWQLVKTLE 2668 +RP F L LE Sbjct: 504 ERPTFEYLQAFLE 516
>Q13153:PAK1_HUMAN Serine/threonine-protein kinase PAK 1 - Homo sapiens (Human)| Length = 545 Score = 115 bits (289), Expect = 8e-25 Identities = 107/433 (24%), Positives = 189/433 (43%), Gaps = 13/433 (3%) Frame = +2 Query: 1400 KSEKSKAPRARSLV-------KSPSSMMLLSYLNKAYPNQGSSVQNADGSLHKPRSKSPL 1558 KSE+ K P+A V K+ +S +S+ +K+ + SS + ++ S Sbjct: 114 KSEQKKNPQAVLDVLEFYNSKKTSNSQKYMSFTDKSAEDYNSS------NALNVKAVSET 167 Query: 1559 PSVVPSDTFREARASSQRFTSPPP---KRVGSDKSVYGKSLGREQCDMAASPDWCSTPVV 1729 P+V P E +PPP R KSVY +S+ E + + D ++P+ Sbjct: 168 PAVPPVS---EDEDDDDDDATPPPVIAPRPEHTKSVYTRSV-IEPLPVTPTRDVATSPIS 223 Query: 1730 FGEHSSQKDSSWTRRYFDNVGRRRVSAVENVRSRTVSMAQAVQSTVDWKLDKAKLLVGHS 1909 E+++ + TR + ++S E + + ++S V K K Sbjct: 224 PTENNTTPPDALTRNTEKQKKKPKMSDEE--------ILEKLRSIVSVGDPKKKYTRFEK 275 Query: 1910 FASGAHSRLYRGL--YDDKPVAIKFIRRPHEDPGGIMAAKLDKQYNTEINALSHLYHKNV 2083 GA +Y + + VAIK + + ++ EI + + N+ Sbjct: 276 IGQGASGTVYTAMDVATGQEVAIKQMNLQQQPKKELII--------NEILVMRENKNPNI 327 Query: 2084 IKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIALEIARGLEYVHSQG 2263 + + ++ G +++ E L GGSL + + + ++ E + LE++HS Sbjct: 328 VNYLDSYLVGDELWVVMEYLAGGSLTDVV---TETCMDEGQIAAVCRECLQALEFLHSNQ 384 Query: 2264 VVHRDIKPENILFDENFEVKIADFGI-AXXXXXXXXXXXXXGTYRWMAPEMIKRKPYNRK 2440 V+HRDIK +NIL + VK+ DFG A GT WMAPE++ RK Y K Sbjct: 385 VIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPK 444 Query: 2441 VDVYSFGLLLWEMVTGRIPFENLSPVQVAYAVATDKLKPMDPQDYCPAAVRPLIEQCCAL 2620 VD++S G++ EM+ G P+ N +P++ Y +AT+ + + A R + +C + Sbjct: 445 VDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLEM 504 Query: 2621 QPEKRPDFWQLVK 2659 EKR +L++ Sbjct: 505 DVEKRGSAKELLQ 517
>Q07014:LYN_RAT Tyrosine-protein kinase Lyn - Rattus norvegicus (Rat)| Length = 512 Score = 115 bits (289), Expect = 8e-25 Identities = 76/270 (28%), Positives = 131/270 (48%), Gaps = 4/270 (1%) Frame = +2 Query: 1871 WKLDKAKLLVGHSFASGAHSRLYRGLYDDKP-VAIKFIRRPHEDPGGIMAAKLDKQYNTE 2047 W++ + + + +G ++ G Y++ VA+K ++ PG + A + + E Sbjct: 240 WEIPRESIKLVKKLGAGQFGEVWMGYYNNSTKVAVKTLK-----PGTMSA----QAFLEE 290 Query: 2048 INALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIALE 2227 N + L H +++L A YIITE + GSL +L + E + L + I + + Sbjct: 291 ANLMKTLQHDKLVRLYAVVTKEEPIYIITEFMAKGSLLDFLKSDEGSKVLLPKLIDFSAQ 350 Query: 2228 IARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIAXXXXXXXXXXXXXGTY--RWM 2401 IA G+ Y+ + +HRD++ N+L E+ KIADFG+A + +W Sbjct: 351 IAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWT 410 Query: 2402 APEMIKRKPYNRKVDVYSFGLLLWEMVT-GRIPFENLSPVQVAYAVATDKLKPMDPQDYC 2578 APE I + K DV+SFG+LL+E+VT G+IP+ + V A++ P + C Sbjct: 411 APEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPR--MENC 468 Query: 2579 PAAVRPLIEQCCALQPEKRPDFWQLVKTLE 2668 P + +++ C E+RP F L L+ Sbjct: 469 PDELYDIMKMCWKESAEERPTFDYLQSVLD 498
>P53667:LIMK1_HUMAN LIM domain kinase 1 - Homo sapiens (Human)| Length = 647 Score = 115 bits (289), Expect = 8e-25 Identities = 76/257 (29%), Positives = 120/257 (46%), Gaps = 24/257 (9%) Frame = +2 Query: 1979 IRRPHEDPGGIMAAK--------LDKQYNTEINALSHLYHKNVIKLVATHKCGPVYYIIT 2134 I+ H + G +M K + + E+ + L H NV+K + IT Sbjct: 354 IKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGVLYKDKRLNFIT 413 Query: 2135 ELLPGGSLRSYLHNPEHRPLPLERTISIALEIARGLEYVHSQGVVHRDIKPENILFDENF 2314 E + GG+LR + + + + P + +S A +IA G+ Y+HS ++HRD+ N L EN Sbjct: 414 EYIKGGTLRGIIKSMDSQ-YPWSQRVSFAKDIASGMAYLHSMNIIHRDLNSHNCLVRENK 472 Query: 2315 EVKIADFGIA---------------XXXXXXXXXXXXXGTYRWMAPEMIKRKPYNRKVDV 2449 V +ADFG+A G WMAPEMI + Y+ KVDV Sbjct: 473 NVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPYWMAPEMINGRSYDEKVDV 532 Query: 2450 YSFGLLLWEMVTGRIPFE-NLSPVQVAYAVATDKLKPMDPQDYCPAAVRPLIEQCCALQP 2626 +SFG++L E++ GR+ + + P + + + CP + P+ +CC L P Sbjct: 533 FSFGIVLCEII-GRVNADPDYLPRTMDFGLNVRGFLDRYCPPNCPPSFFPITVRCCDLDP 591 Query: 2627 EKRPDFWQLVKTLEKIQ 2677 EKRP F +L LE ++ Sbjct: 592 EKRPSFVKLEHWLETLR 608
>P00544:FGR_FSVGR Tyrosine-protein kinase transforming protein Fgr - Feline sarcoma| virus (strain Gardner-Rasheed) Length = 545 Score = 115 bits (289), Expect = 8e-25 Identities = 81/292 (27%), Positives = 143/292 (48%), Gaps = 4/292 (1%) Frame = +2 Query: 1805 SAVENVRSRTVSMAQAVQSTVDWKLDKAKLLVGHSFASGAHSRLYRGLYDDKP-VAIKFI 1981 +A ++ +T+ +A+ W++ ++ + + +G ++ G+++ VA+K + Sbjct: 262 AACTTMKPQTMGLAKDA-----WEISRSSITLQRRLGTGCFGDVWLGMWNGSTKVAVKTL 316 Query: 1982 RRPHEDPGGIMAAKLDKQYNTEINALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLR 2161 + G M+ K + E + L H +++L A P+Y I+TE + GSL Sbjct: 317 KP------GTMSPKASLE---EAQIMKLLRHDKLVQLYAVVPEEPIY-IVTEFMCHGSLL 366 Query: 2162 SYLHNPEHRPLPLERTISIALEIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGI 2341 +L + E + L L + + +A ++A G+ Y+ +HRD++ NIL E KIADFG+ Sbjct: 367 EFLKDQEGQDLTLPQLVDMAAQVAEGMAYMERMDYIHRDLRAANILVGERLVCKIADFGL 426 Query: 2342 AXXXXXXXXXXXXXGTY--RWMAPEMIKRKPYNRKVDVYSFGLLLWEMVT-GRIPFENLS 2512 A + +W APE + K DV+SFG+LL E+++ GR+P+ ++ Sbjct: 427 ARLIEDNEYNPRQGAKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELISKGRVPYPGMN 486 Query: 2513 PVQVAYAVATDKLKPMDPQDYCPAAVRPLIEQCCALQPEKRPDFWQLVKTLE 2668 +V V P P CPA++ +EQ L PE+RP F L LE Sbjct: 487 NREVLEQVEHGYHMPCPPG--CPASLYEAMEQTWRLDPEERPTFEYLQSFLE 536
>P22455:FGFR4_HUMAN Fibroblast growth factor receptor 4 precursor - Homo sapiens (Human)| Length = 802 Score = 115 bits (289), Expect = 8e-25 Identities = 85/303 (28%), Positives = 142/303 (46%), Gaps = 29/303 (9%) Frame = +2 Query: 1871 WKLDKAKLLVGHSFASGAHSRLYRGLYDDKPVAIKFIRRPHEDPGGIMAAKLDKQYNTEI 2050 W+ + +L++G G ++ R A RP D +A K+ K ++ Sbjct: 460 WEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPA-----RP--DQASTVAVKMLKDNASDK 512 Query: 2051 NALSHLYHKNVIKLVATHK--------C---GPVYYIITELLPGGSLRSYLH-------- 2173 + + V+KL+ HK C GP+Y +I E G+LR +L Sbjct: 513 DLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLY-VIVECAAKGNLREFLRARRPPGPD 571 Query: 2174 ------NPEHRPLPLERTISIALEIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADF 2335 PL +S A ++ARG++Y+ S+ +HRD+ N+L E+ +KIADF Sbjct: 572 LSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADF 631 Query: 2336 GIAXXXXXXXXXXXXXG---TYRWMAPEMIKRKPYNRKVDVYSFGLLLWEMVT-GRIPFE 2503 G+A +WMAPE + + Y + DV+SFG+LLWE+ T G P+ Sbjct: 632 GLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYP 691 Query: 2504 NLSPVQVAYAVATDKLKPMDPQDYCPAAVRPLIEQCCALQPEKRPDFWQLVKTLEKIQSV 2683 + PV+ +++ + + MD +CP + L+ +C P +RP F QLV+ L+K+ Sbjct: 692 GI-PVEELFSLLREGHR-MDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVLLA 749 Query: 2684 MSQ 2692 +S+ Sbjct: 750 VSE 752
>Q02977:YRK_CHICK Proto-oncogene tyrosine-protein kinase Yrk - Gallus gallus (Chicken)| Length = 536 Score = 115 bits (288), Expect = 1e-24 Identities = 81/284 (28%), Positives = 135/284 (47%), Gaps = 5/284 (1%) Frame = +2 Query: 1832 TVSMAQAVQSTVD-WKLDKAKLLVGHSFASGAHSRLYRGLYDDKP-VAIKFIRRPHEDPG 2005 T +A T D W++ + L + +G ++ G ++ VA+K ++ P Sbjct: 249 TPKLADLSVKTKDVWEIPRESLQLLQKLGNGQFGEVWMGTWNGTTKVAVKTLKPGTMSPE 308 Query: 2006 GIMAAKLDKQYNTEINALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEH 2185 + E + L H +++L A P+Y I+TE + GSL +L + + Sbjct: 309 AFLE---------EAQIMKRLRHDKLVQLYAVVSEEPIY-IVTEFMSQGSLLDFLKDGDG 358 Query: 2186 RPLPLERTISIALEIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIAXXXXXXX 2365 R L L + + +A +IA G+ Y+ +HRD++ NIL +N KIADFG+A Sbjct: 359 RYLKLPQLVDMAAQIAAGMAYIERMNYIHRDLRAANILVGDNLVCKIADFGLARLIEDNE 418 Query: 2366 XXXXXXGTY--RWMAPEMIKRKPYNRKVDVYSFGLLLWEMVT-GRIPFENLSPVQVAYAV 2536 + +W APE + K DV+SFG+LL E+VT GR+P+ ++ +V V Sbjct: 419 YTARQGAKFPIKWTAPEAALFGKFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQV 478 Query: 2537 ATDKLKPMDPQDYCPAAVRPLIEQCCALQPEKRPDFWQLVKTLE 2668 ++ M CP ++ ++ QC +PE+RP F L LE Sbjct: 479 --ERGYRMQCPGGCPPSLHDVMVQCWKREPEERPTFEYLQSFLE 520
>P42686:SRK1_SPOLA Tyrosine-protein kinase isoform SRK1 - Spongilla lacustris| (Freshwater sponge) Length = 505 Score = 115 bits (288), Expect = 1e-24 Identities = 76/274 (27%), Positives = 132/274 (48%), Gaps = 8/274 (2%) Frame = +2 Query: 1856 QSTVDWKLDKAKLLVGHSFASGAHSRLYRGLYDDKP-VAIKFIRRPHEDPGGIMAAKLDK 2032 Q+ +W+++K ++ + +G ++ GL++ VA+K ++ PG + + Sbjct: 228 QANEEWEIEKTQIKLLRRLGAGQFGEVWEGLWNGTTSVAVKTLK-----PGTMSV----E 278 Query: 2033 QYNTEINALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTI 2212 ++ E + + L H +I+L A YI+TEL+ GSL YL E L +E+ + Sbjct: 279 EFLQEASIMKRLRHPKLIQLYAVCTKEEPIYIVTELMKYGSLLEYLRG-EDGVLKIEQLV 337 Query: 2213 SIALEIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIAXXXXXXXXXXXXXGTY 2392 +A ++A G+ Y+ Q +HRD+ NIL E+ K+ADFG+A + Sbjct: 338 DVAAQVASGMSYLEQQNYIHRDLAARNILVGEHGICKVADFGLARVIDEEIYEAHTGAKF 397 Query: 2393 --RWMAPEMIKRKPYNRKVDVYSFGLLLWEMVT-GRIPFENLSPVQVAYAVATDKLKPMD 2563 +W APE + K DV+SFG++L+E++T GR P+ ++ +V + + P Sbjct: 398 PIKWTAPEAAMYNRFTIKSDVWSFGVVLYEIITYGRFPYPGMTNPEVLEKIQQNYRMPCP 457 Query: 2564 PQDYCPAAVRPLIEQCCALQPEKRPDF----WQL 2653 CP ++ C P RP F WQL Sbjct: 458 AN--CPKQFHDIMLDCWREDPASRPTFETLQWQL 489
>Q9WUD9:SRC_RAT Proto-oncogene tyrosine-protein kinase Src - Rattus norvegicus (Rat)| Length = 536 Score = 115 bits (288), Expect = 1e-24 Identities = 85/314 (27%), Positives = 144/314 (45%), Gaps = 4/314 (1%) Frame = +2 Query: 1739 HSSQKDSSWTRRYFDNVGRRRVSAVENVRSRTVSMAQAVQSTVDWKLDKAKLLVGHSFAS 1918 +S Q+ ++ ++ D + R + + +T +A+ W++ + L + Sbjct: 224 NSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDA-----WEIPRESLRLEVKLGQ 278 Query: 1919 GAHSRLYRGLYDDKP-VAIKFIRRPHEDPGGIMAAKLDKQYNTEINALSHLYHKNVIKLV 2095 G ++ G ++ VAIK ++ P + E + L H+ +++L Sbjct: 279 GCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQ---------EAQVMKKLRHEKLVQLY 329 Query: 2096 ATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIALEIARGLEYVHSQGVVHR 2275 A P+Y I+TE + GSL +L + L L + + ++ +IA G+ YV VHR Sbjct: 330 AVVSEEPIY-IVTEYMNKGSLLDFLKGETGKYLRLPQLVDMSAQIASGMAYVDRMNYVHR 388 Query: 2276 DIKPENILFDENFEVKIADFGIAXXXXXXXXXXXXXGTY--RWMAPEMIKRKPYNRKVDV 2449 D++ NIL EN K+ADFG+A + +W APE + K DV Sbjct: 389 DLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDV 448 Query: 2450 YSFGLLLWEMVT-GRIPFENLSPVQVAYAVATDKLKPMDPQDYCPAAVRPLIEQCCALQP 2626 +SFG+LL E+ T GR+P+ + +V V P P+ CP ++ L+ QC +P Sbjct: 449 WSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPE--CPESLHDLMCQCWRKEP 506 Query: 2627 EKRPDFWQLVKTLE 2668 E+RP F L LE Sbjct: 507 EERPTFEYLQAFLE 520
>O88643:PAK1_MOUSE Serine/threonine-protein kinase PAK 1 - Mus musculus (Mouse)| Length = 545 Score = 115 bits (288), Expect = 1e-24 Identities = 108/432 (25%), Positives = 194/432 (44%), Gaps = 12/432 (2%) Frame = +2 Query: 1400 KSEKSKAPRARSLV-------KSPSSMMLLSYLNKAYPNQGSSVQNADGSLH-KPRSKSP 1555 KSE+ K P+A V K+ +S +S+ +K+ + SS +L+ K S++P Sbjct: 114 KSEQKKNPQAVLDVLEFYNSKKTSNSKKYMSFTDKSAEDYNSS-----NTLNVKTVSETP 168 Query: 1556 -LPSVVPSDTFREARASSQRFTSPPPKRVGSDKSVYGKSLGREQCDMAASPDWCSTPVVF 1732 +P V D + A+ +P P+ KSVY +S+ E + + D ++P+ Sbjct: 169 AVPPVSEDDEDDDDDATPPPVIAPRPEHT---KSVYTRSV-IEPLPVTPTRDVATSPISP 224 Query: 1733 GEHSSQKDSSWTRRYFDNVGRRRVSAVENVRSRTVSMAQAVQSTVDWKLDKAKLLVGHSF 1912 E+++ + TR + ++S E + + ++S V K K Sbjct: 225 TENNTTPPDALTRNTEKQKKKPKMSDEE--------ILEKLRSIVSVGDPKKKYTPFEKI 276 Query: 1913 ASGAHSRLYRGL--YDDKPVAIKFIRRPHEDPGGIMAAKLDKQYNTEINALSHLYHKNVI 2086 GA +Y + + VAIK + + ++ EI + + N++ Sbjct: 277 GQGASGTVYTAMDVATGQEVAIKQMNLQQQPKKELII--------NEILVMRENKNPNIV 328 Query: 2087 KLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIALEIARGLEYVHSQGV 2266 + ++ G +++ E L GGSL + + + ++ E + LE++HS V Sbjct: 329 NYLDSYLVGDELWVVMEYLAGGSLTDVV---TETCMDEGQIAAVCRECLQALEFLHSNQV 385 Query: 2267 VHRDIKPENILFDENFEVKIADFGI-AXXXXXXXXXXXXXGTYRWMAPEMIKRKPYNRKV 2443 +HRDIK +NIL + VK+ DFG A GT WMAPE++ RK Y KV Sbjct: 386 IHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKV 445 Query: 2444 DVYSFGLLLWEMVTGRIPFENLSPVQVAYAVATDKLKPMDPQDYCPAAVRPLIEQCCALQ 2623 D++S G++ EM+ G P+ N +P++ Y +AT+ + + A R ++ C + Sbjct: 446 DIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLQCCLEMD 505 Query: 2624 PEKRPDFWQLVK 2659 EKR +L++ Sbjct: 506 VEKRGSAKELLQ 517
>P18160:KYK1_DICDI Non-receptor tyrosine kinase spore lysis A - Dictyostelium discoideum| (Slime mold) Length = 1584 Score = 115 bits (288), Expect = 1e-24 Identities = 82/292 (28%), Positives = 146/292 (50%), Gaps = 22/292 (7%) Frame = +2 Query: 1868 DWKLDKAKLLVGHSFASGAHSRLYRGLYDDKPVAIKFIRRPHEDPGGIMAAKLDKQYNTE 2047 ++++D +L G + G + RG + + VAIK I R + + E Sbjct: 1281 EYEIDFNELEFGQTIGKGFFGEVKRGYWRETDVAIKIIYRDQFKTKSSLV-----MFQNE 1335 Query: 2048 INALSHLYHKNVIKLVATHKCGPV--YYIITELLPGGSLRSYLHNPEHRPLPLERT---- 2209 + LS L H NV++ + G + I+TE + GGSLR +L +H L LE+ Sbjct: 1336 VGILSKLRHPNVVQFLGACTAGGEDHHCIVTEWMGGGSLRQFL--TDHFNL-LEQNPHIR 1392 Query: 2210 ISIALEIARGLEYVH--SQGVVHRDIKPENILFDENFE-------------VKIADFGIA 2344 + +AL+IA+G+ Y+H + ++HRD+ NIL D N + KI+DFG++ Sbjct: 1393 LKLALDIAKGMNYLHGWTPPILHRDLSSRNILLDHNIDPKNPVVSSRQDIKCKISDFGLS 1452 Query: 2345 XXXXXXXXXXXXX-GTYRWMAPEMIKRKPYNRKVDVYSFGLLLWEMVTGRIPFENLSPVQ 2521 G +MAPE+ K + K DVYS+G++L+E++T P +++ P++ Sbjct: 1453 RLKKEQASQMTQSVGCIPYMAPEVFKGDSNSEKSDVYSYGMVLFELLTSDEPQQDMKPMK 1512 Query: 2522 VAYAVATDKLKPMDPQDYCPAAVRPLIEQCCALQPEKRPDFWQLVKTLEKIQ 2677 +A+ A + +P P + + ++ QC P+ RP F Q++ L++++ Sbjct: 1513 MAHLAAYESYRPPIPLT-TSSKWKEILTQCWDSNPDSRPTFKQIIVHLKEME 1563
>P14234:FGR_MOUSE Proto-oncogene tyrosine-protein kinase FGR - Mus musculus (Mouse)| Length = 517 Score = 115 bits (288), Expect = 1e-24 Identities = 79/270 (29%), Positives = 130/270 (48%), Gaps = 4/270 (1%) Frame = +2 Query: 1871 WKLDKAKLLVGHSFASGAHSRLYRGLYD-DKPVAIKFIRRPHEDPGGIMAAKLDKQYNTE 2047 W++D+ + + +G ++ G ++ VA+K ++ P K + E Sbjct: 244 WEIDRNSIALERRLGTGCFGDVWLGTWNCSTKVAVKTLKPGTMSP---------KAFLEE 294 Query: 2048 INALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIALE 2227 + L H +++L A P+Y I+TE + GSL +L + E + L L + +A + Sbjct: 295 AQIMKLLRHDKLVQLYAVVSEEPIY-IVTEFMCYGSLLDFLKDREGQNLMLPHLVDMAAQ 353 Query: 2228 IARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIAXXXXXXXXXXXXXGTY--RWM 2401 +A G+ Y+ +HRD++ NIL E KIADFG+A + +W Sbjct: 354 VAEGMAYMERMNYIHRDLRAANILVGEYLICKIADFGLARLIEDNEYNPQQGTKFPIKWT 413 Query: 2402 APEMIKRKPYNRKVDVYSFGLLLWEMVT-GRIPFENLSPVQVAYAVATDKLKPMDPQDYC 2578 APE + K DV+SFG+LL E++T GR+P+ ++ +V V P P C Sbjct: 414 APEAALFGRFTVKSDVWSFGILLTELITKGRVPYPGMNNREVLEQVEHGYHMPCPPG--C 471 Query: 2579 PAAVRPLIEQCCALQPEKRPDFWQLVKTLE 2668 PA++ ++EQ L PE+RP F L LE Sbjct: 472 PASLYEVMEQAWRLDPEERPTFEYLQSFLE 501
>Q8MY86:FGFR1_DUGJA Fibroblast growth factor receptor 1 precursor - Dugesia japonica| (Planarian) Length = 854 Score = 115 bits (288), Expect = 1e-24 Identities = 87/287 (30%), Positives = 139/287 (48%), Gaps = 22/287 (7%) Frame = +2 Query: 1871 WKLDKAKL-LVGHSFASGAHSRLYRGLYDDK-------PVAIKFIRRPHEDPGGIMAAKL 2026 W+ + KL + GA +Y G+ +D VA+K +R D Sbjct: 543 WEFPREKLKITNKKLGEGAFGMVYEGIANDIGNRSNPIKVAVKMMRDDFSDSNV------ 596 Query: 2027 DKQYNTEINALSHL-YHKNVIKLVA--THKCGPVYYIITELLPGGSLRSYLHNPEHRPLP 2197 + E+ + H+ H NVI+L+ T K GP+ +I EL P G+LR ++ + Sbjct: 597 -HDFVKEMEIMKHIGRHPNVIQLLGLCTQK-GPLR-VIVELAPYGNLRDFVRAKNKKYSK 653 Query: 2198 LERTI---------SIALEIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIA-X 2347 ++ I + +L+IARG+ Y+ S+ VVHRD+ NIL E+FE+KIADFG+ Sbjct: 654 SKKIIGNFTSSILCTYSLQIARGMTYLASRSVVHRDLSARNILVGEHFEMKIADFGLTRI 713 Query: 2348 XXXXXXXXXXXXGTYRWMAPEMIKRKPYNRKVDVYSFGLLLWEMVT-GRIPFENLSPVQV 2524 +WMAPE + K Y K DV+S+G+LLWE+ T G P+ + P +V Sbjct: 714 VDYYYRKKTDGILPVKWMAPEALLEKKYTTKSDVWSYGILLWEIFTLGDSPYSAILPEKV 773 Query: 2525 AYAVATDKLKPMDPQDYCPAAVRPLIEQCCALQPEKRPDFWQLVKTL 2665 + P + + L++ C +L E RP+F+++V+ L Sbjct: 774 VDLIRKGFQNP--KPELANFEIYRLMQHCWSLSSENRPNFFEIVEIL 818
>Q4JIM5:ABL2_MOUSE Tyrosine-protein kinase ABL2 - Mus musculus (Mouse)| Length = 1182 Score = 115 bits (288), Expect = 1e-24 Identities = 68/269 (25%), Positives = 127/269 (47%), Gaps = 3/269 (1%) Frame = +2 Query: 1871 WKLDKAKLLVGHSFASGAHSRLYRGLYDDKPVAIKFIRRPHEDPGGIMAAKLDKQYNTEI 2050 W++++ + + H G + +Y G++ + + ++ ED + +++ E Sbjct: 281 WEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVA-VKTFKEDTMEV------EEFLKEA 333 Query: 2051 NALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIALEI 2230 + + H N+++L+ P +YI+TE +P G+L YL + + +A +I Sbjct: 334 AVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECSREEVTAVVLLYMATQI 393 Query: 2231 ARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIAXXXXXXXXXXXXXGTY--RWMA 2404 + +EY+ + +HRD+ N L EN VK+ADFG++ + +W A Sbjct: 394 SSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTA 453 Query: 2405 PEMIKRKPYNRKVDVYSFGLLLWEMVT-GRIPFENLSPVQVAYAVATDKLKPMDPQDYCP 2581 PE + ++ K DV++FG+LLWE+ T G P+ + QV + +K M+ + CP Sbjct: 454 PESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLL--EKGYRMEQPEGCP 511 Query: 2582 AAVRPLIEQCCALQPEKRPDFWQLVKTLE 2668 V L+ C P RP F + + E Sbjct: 512 PKVYELMRACWKWSPADRPSFAETHQAFE 540
>Q6BNF3:STE20_DEBHA Serine/threonine-protein kinase STE20 - Debaryomyces hansenii (Yeast)| (Torulaspora hansenii) Length = 1079 Score = 115 bits (287), Expect = 1e-24 Identities = 114/480 (23%), Positives = 210/480 (43%), Gaps = 13/480 (2%) Frame = +2 Query: 1256 PIDRDNDKTVAALKHTASLPSLRSTLQPNEKKASKQKMSLEIPLSPPAKSEKSKAPRARS 1435 P N ALK + + S+ + S +K+S E P +P +K S Sbjct: 588 PSPSTNTNISPALKKNSFMGRSFSSKSIKALRNSNRKIS-EPPKAPQSKISDSNTEMG-- 644 Query: 1436 LVKSPSSMMLLSYLNKAYPNQGSSVQNADGSLHKPRSKSPLPSVVPSDTFREARASSQRF 1615 + KS S LS ++ P +GS+ A S + + + ++ + E + ++ Sbjct: 645 IPKSKSHSNSLSTQSEVEPTKGSTT--APVSSTAKFNSTTINNINGHNIIEEEKNNNTLL 702 Query: 1616 TSPPPKRVGSDKSVYGKSLGREQCDMAASPDWCSTPVVFGEHSSQKDSSWTRRYFDNVGR 1795 ++P + D ++ E+ D SP S V E S++K++S +N Sbjct: 703 SNPKQREQKPDSTI-------EKRDTPPSP---SQSRVSEEESTKKETSEKYNNKENDIP 752 Query: 1796 RRVSAVENVRSRTVSMAQAVQSTVDWKLDKAKLL--VGHSFASGAHSRLYRGLYDDKPVA 1969 ++ S+ + VR + A + D K +++ + + G + LY+ L A Sbjct: 753 KK-SSQQPVRDAKQAALLAQKKREDKKRKNQQIISKLQQICSEGDPNELYKDLMKIGQGA 811 Query: 1970 IKFIRRPHE-----DPGGIMAAKLDKQYN-----TEINALSHLYHKNVIKLVATHKCGPV 2119 + H+ I L++Q EI + H+N++ + ++ Sbjct: 812 SGGVYIAHDVNHRSQTVAIKQMNLEQQPKKELIINEILVMKGSKHENIVNFIDSYLLRGD 871 Query: 2120 YYIITELLPGGSLRSYLHNPEHRPLPLERTISIALEIARGLEYVHSQGVVHRDIKPENIL 2299 +++ E + GGSL + H + + ++ E +GL ++HS+GV+HRDIK +NIL Sbjct: 872 LWVVMEYMEGGSLTEIV---THSVMTEGQIGAVCRETLKGLRFLHSKGVIHRDIKSDNIL 928 Query: 2300 FDENFEVKIADFGI-AXXXXXXXXXXXXXGTYRWMAPEMIKRKPYNRKVDVYSFGLLLWE 2476 + + +K+ DFG A GT WMAPE++ RK Y KVDV+S G+++ E Sbjct: 929 LNIDGNIKMTDFGFCAQINEINLKRTTMVGTPYWMAPEVVSRKEYGPKVDVWSLGIMIIE 988 Query: 2477 MVTGRIPFENLSPVQVAYAVATDKLKPMDPQDYCPAAVRPLIEQCCALQPEKRPDFWQLV 2656 M+ G P+ N +P++ Y +AT+ + + +R + C + KR + QL+ Sbjct: 989 MIEGEPPYLNETPLRALYLIATNGTPKLKEPEALSYDIRKFLSWCLQVDFNKRGNADQLL 1048
>P00524:SRC_RSVSA Tyrosine-protein kinase transforming protein Src - Avian leukosis| virus RSA (RSV-SRA) (Rous sarcoma virus (strain Schmidt-Ruppin A)) Length = 526 Score = 115 bits (287), Expect = 1e-24 Identities = 83/305 (27%), Positives = 139/305 (45%), Gaps = 4/305 (1%) Frame = +2 Query: 1742 SSQKDSSWTRRYFDNVGRRRVSAVENVRSRTVSMAQAVQSTVDWKLDKAKLLVGHSFASG 1921 S Q+ ++ ++ D + R + + +T +A+ W++ + L + G Sbjct: 222 SLQQLVAYYSKHADGLCHRLTNVCPTSKPQTQGLAKDA-----WEIPRESLRLEVKLGQG 276 Query: 1922 AHSRLYRGLYDDKP-VAIKFIRRPHEDPGGIMAAKLDKQYNTEINALSHLYHKNVIKLVA 2098 ++ G ++ VAIK ++ P + E + L H+ +++L A Sbjct: 277 CFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQ---------EAQVMKKLRHEKLVQLYA 327 Query: 2099 THKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIALEIARGLEYVHSQGVVHRD 2278 P+Y I+TE + GSL +L + L L + + +A +IA G+ YV VHRD Sbjct: 328 VVSEEPIY-IVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERMNYVHRD 386 Query: 2279 IKPENILFDENFEVKIADFGIAXXXXXXXXXXXXXGTY--RWMAPEMIKRKPYNRKVDVY 2452 ++ NIL EN K+ADFG+A + +W APE + K DV+ Sbjct: 387 LRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVW 446 Query: 2453 SFGLLLWEMVT-GRIPFENLSPVQVAYAVATDKLKPMDPQDYCPAAVRPLIEQCCALQPE 2629 SFG+LL E+ T GR+P+ + +V V P P+ CP ++ L+ QC PE Sbjct: 447 SFGILLTELTTKGRVPYPGMGNGEVLDRVERGYRMPCPPE--CPESLHDLMCQCWRRDPE 504 Query: 2630 KRPDF 2644 +RP F Sbjct: 505 ERPTF 509
>P00526:SRC_RSVP Tyrosine-protein kinase transforming protein Src - Rous sarcoma virus| (strain Prague C) (RSV-PrC) Length = 526 Score = 115 bits (287), Expect = 1e-24 Identities = 83/305 (27%), Positives = 139/305 (45%), Gaps = 4/305 (1%) Frame = +2 Query: 1742 SSQKDSSWTRRYFDNVGRRRVSAVENVRSRTVSMAQAVQSTVDWKLDKAKLLVGHSFASG 1921 S Q+ ++ ++ D + R + + +T +A+ W++ + L + G Sbjct: 222 SLQQLVAYYSKHADGLCHRLANVCPTSKPQTQGLAKDA-----WEIPRESLRLEAKLGQG 276 Query: 1922 AHSRLYRGLYDDKP-VAIKFIRRPHEDPGGIMAAKLDKQYNTEINALSHLYHKNVIKLVA 2098 ++ G ++D VAIK ++ P + E + L H+ +++L A Sbjct: 277 CFGEVWMGTWNDTTRVAIKTLKPGTMSPEAFLQ---------EAQVMKKLRHEKLVQLYA 327 Query: 2099 THKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIALEIARGLEYVHSQGVVHRD 2278 P+Y +I E + GSL +L + L L + + +A +IA G+ YV VHRD Sbjct: 328 VVSEEPIYIVI-EYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERMNYVHRD 386 Query: 2279 IKPENILFDENFEVKIADFGIAXXXXXXXXXXXXXGTY--RWMAPEMIKRKPYNRKVDVY 2452 ++ NIL EN K+ADFG+A + +W APE + K DV+ Sbjct: 387 LRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVW 446 Query: 2453 SFGLLLWEMVT-GRIPFENLSPVQVAYAVATDKLKPMDPQDYCPAAVRPLIEQCCALQPE 2629 SFG+LL E+ T GR+P+ + +V V P P+ CP ++ L+ QC PE Sbjct: 447 SFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPE--CPESLHDLMCQCWRKDPE 504 Query: 2630 KRPDF 2644 +RP F Sbjct: 505 ERPTF 509
>P00525:SRC_AVISR Tyrosine-protein kinase transforming protein Src - Avian sarcoma| virus (strain rASV1441) Length = 526 Score = 115 bits (287), Expect = 1e-24 Identities = 83/305 (27%), Positives = 139/305 (45%), Gaps = 4/305 (1%) Frame = +2 Query: 1742 SSQKDSSWTRRYFDNVGRRRVSAVENVRSRTVSMAQAVQSTVDWKLDKAKLLVGHSFASG 1921 S Q+ ++ ++ D + R + + +T +A+ W++ + L + G Sbjct: 222 SLQQLVAYYSKHADGLCHRLTNVCPTSKPQTQGLAKDA-----WEIPRESLRLEVKLGQG 276 Query: 1922 AHSRLYRGLYDDKP-VAIKFIRRPHEDPGGIMAAKLDKQYNTEINALSHLYHKNVIKLVA 2098 ++ G ++ VAIK ++ P + E + L H+ +++L A Sbjct: 277 CFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQ---------EAQVMKKLRHEKLVQLYA 327 Query: 2099 THKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIALEIARGLEYVHSQGVVHRD 2278 P+Y I+TE + GSL +L + L L + + +A +IA G+ YV VHRD Sbjct: 328 VVSEEPIY-IVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERMNYVHRD 386 Query: 2279 IKPENILFDENFEVKIADFGIAXXXXXXXXXXXXXGTY--RWMAPEMIKRKPYNRKVDVY 2452 ++ NIL EN K+ADFG+A + +W APE + K DV+ Sbjct: 387 LRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVW 446 Query: 2453 SFGLLLWEMVT-GRIPFENLSPVQVAYAVATDKLKPMDPQDYCPAAVRPLIEQCCALQPE 2629 SFG+LL E+ T GR+P+ + +V V P P+ CP ++ L+ QC PE Sbjct: 447 SFGILLTELTTKGRVPYPGMGNGEVLDRVERGYRMPCPPE--CPESLHDLMCQCWRRDPE 504 Query: 2630 KRPDF 2644 +RP F Sbjct: 505 ERPTF 509
>Q08E52:PAK1_BOVIN Serine/threonine-protein kinase PAK 1 - Bos taurus (Bovine)| Length = 544 Score = 115 bits (287), Expect = 1e-24 Identities = 106/431 (24%), Positives = 191/431 (44%), Gaps = 11/431 (2%) Frame = +2 Query: 1400 KSEKSKAPRARSLV-------KSPSSMMLLSYLNKAYPNQGSSVQNADGSLH-KPRSKSP 1555 KSE+ K P+A V K+ +S +S+ +K+ + SS +L+ K S++P Sbjct: 114 KSEQKKNPQAVLDVLEFYNSKKTSNSQKYMSFTDKSAEDYNSS-----NTLNVKAVSETP 168 Query: 1556 LPSVVPSDTFREARASSQRFTSPPPKRVGSDKSVYGKSLGREQCDMAASPDWCSTPVVFG 1735 V D + + +P P+ KSVY +S+ E + + D ++P+ Sbjct: 169 AVPPVSEDEDDDDDGTPPPVIAPRPEHT---KSVYTRSV-IEPLPITPTRDVATSPISPT 224 Query: 1736 EHSSQKDSSWTRRYFDNVGRRRVSAVENVRSRTVSMAQAVQSTVDWKLDKAKLLVGHSFA 1915 E+++ + TR + ++S E + + ++S V K K Sbjct: 225 ENNTTPPDALTRNTEKQKKKPKMSDEE--------ILEKLRSIVSVGDPKKKYTRFEKIG 276 Query: 1916 SGAHSRLYRGL--YDDKPVAIKFIRRPHEDPGGIMAAKLDKQYNTEINALSHLYHKNVIK 2089 GA +Y + + VAIK + + ++ EI + + N++ Sbjct: 277 QGASGTVYTAMDVATGQEVAIKQMNLQQQPKKELII--------NEILVMRENKNPNIVN 328 Query: 2090 LVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIALEIARGLEYVHSQGVV 2269 + ++ G +++ E L GGSL + + + ++ E + LE++HS V+ Sbjct: 329 YLDSYLVGDELWVVMEYLAGGSLTDVV---TETCMDEGQIAAVCRECLQALEFLHSNQVI 385 Query: 2270 HRDIKPENILFDENFEVKIADFGI-AXXXXXXXXXXXXXGTYRWMAPEMIKRKPYNRKVD 2446 HRDIK +NIL + VK+ DFG A GT WMAPE++ RK Y KVD Sbjct: 386 HRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVD 445 Query: 2447 VYSFGLLLWEMVTGRIPFENLSPVQVAYAVATDKLKPMDPQDYCPAAVRPLIEQCCALQP 2626 ++S G++ EM+ G P+ N +P++ Y +AT+ + + A R + +C + Sbjct: 446 IWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLEMDV 505 Query: 2627 EKRPDFWQLVK 2659 EKR +L++ Sbjct: 506 EKRGSAKELLQ 516
>P12965:MOS_XENLA Serine/threonine-protein kinase mos - Xenopus laevis (African clawed| frog) Length = 359 Score = 115 bits (287), Expect = 1e-24 Identities = 90/298 (30%), Positives = 144/298 (48%), Gaps = 19/298 (6%) Frame = +2 Query: 1862 TVDWKLDKAKLLVGHSFASGAHSRLYRGLYDDKPVAIKFIRRPHEDPGGIMAAKLDKQYN 2041 ++DW+ ++L+ SG +YR Y + VA+K ++R ++ +A++ + + Sbjct: 57 SIDWE----QVLLLEPLGSGGFGSVYRATYRGETVALKKVKRSTKNS---LASR--QSFW 107 Query: 2042 TEINALSHLYHKNVIKLVATHKCGP-----VYYIITELLPGGSLRSYLHNPEHRPLPLER 2206 E+NA + L H +V+++VA P II E G+L ++ PL E Sbjct: 108 AELNA-ARLRHPHVVRVVAASASCPGDPGCPGTIIMEYTGTGTLHQRIYG-RSPPLGAEI 165 Query: 2207 TISIALEIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGI----------AXXXX 2356 + A +A GL ++H GVVH D+KP N+L KI DFG A Sbjct: 166 CMRYARHVADGLRFLHRDGVVHLDLKPANVLLAPGDLCKIGDFGCSQRLREGDEAAGGEP 225 Query: 2357 XXXXXXXXXGTYRWMAPEMIKRKPYNRKVDVYSFGLLLWEMVTGRIPFENLSPVQVAYAV 2536 GTY APE++K +P K D+YSF + LW+MV+ +P+ V YAV Sbjct: 226 CCTQLRHVGGTYTHRAPELLKGEPVTAKADIYSFAITLWQMVSRELPYTG-DRQCVLYAV 284 Query: 2537 ATDKLKP-MDP---QDYCPAAVRPLIEQCCALQPEKRPDFWQLVKTLEKIQSVMSQGG 2698 L+P M P A R +++ C A +P++RP+ QL++ LE+ + M GG Sbjct: 285 VAYDLRPEMGPLFSHTEEGRAARTIVQSCWAARPQERPNAEQLLERLEQ-ECAMCTGG 341
>P08069:IGF1R_HUMAN Insulin-like growth factor 1 receptor precursor - Homo sapiens| (Human) Length = 1367 Score = 115 bits (287), Expect = 1e-24 Identities = 81/289 (28%), Positives = 137/289 (47%), Gaps = 21/289 (7%) Frame = +2 Query: 1868 DWKLDKAKLLVGHSFASGAHSRLY----RGLYDDKP---VAIKFIRRPHEDPGGIMAAKL 2026 +W++ + K+ + G+ +Y +G+ D+P VAIK + AA + Sbjct: 991 EWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNE---------AASM 1041 Query: 2027 DK--QYNTEINALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYL--------HN 2176 + ++ E + + +V++L+ G +I EL+ G L+SYL +N Sbjct: 1042 RERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENN 1101 Query: 2177 PEHRPLPLERTISIALEIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIAXXXX 2356 P P L + I +A EIA G+ Y+++ VHRD+ N + E+F VKI DFG+ Sbjct: 1102 PVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIY 1161 Query: 2357 XXXXXXXXXG---TYRWMAPEMIKRKPYNRKVDVYSFGLLLWEMVT-GRIPFENLSPVQV 2524 RWM+PE +K + DV+SFG++LWE+ T P++ LS QV Sbjct: 1162 ETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQV 1221 Query: 2525 AYAVATDKLKPMDPQDYCPAAVRPLIEQCCALQPEKRPDFWQLVKTLEK 2671 V L +D D CP + L+ C P+ RP F +++ ++++ Sbjct: 1222 LRFVMEGGL--LDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKE 1268
>P06241:FYN_HUMAN Proto-oncogene tyrosine-protein kinase Fyn - Homo sapiens (Human)| Length = 537 Score = 115 bits (287), Expect = 1e-24 Identities = 80/270 (29%), Positives = 128/270 (47%), Gaps = 4/270 (1%) Frame = +2 Query: 1871 WKLDKAKLLVGHSFASGAHSRLYRGLYD-DKPVAIKFIRRPHEDPGGIMAAKLDKQYNTE 2047 W++ + L + +G ++ G ++ + VAIK ++ P + + E Sbjct: 264 WEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSP---------ESFLEE 314 Query: 2048 INALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIALE 2227 + L H +++L A P+Y I+TE + GSL +L + E R L L + +A + Sbjct: 315 AQIMKKLKHDKLVQLYAVVSEEPIY-IVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQ 373 Query: 2228 IARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIAXXXXXXXXXXXXXGTY--RWM 2401 +A G+ Y+ +HRD++ NIL KIADFG+A + +W Sbjct: 374 VAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWT 433 Query: 2402 APEMIKRKPYNRKVDVYSFGLLLWEMVT-GRIPFENLSPVQVAYAVATDKLKPMDPQDYC 2578 APE + K DV+SFG+LL E+VT GR+P+ ++ +V V P PQD C Sbjct: 434 APEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPC-PQD-C 491 Query: 2579 PAAVRPLIEQCCALQPEKRPDFWQLVKTLE 2668 P ++ L+ C PE+RP F L LE Sbjct: 492 PISLHELMIHCWKKDPEERPTFEYLQSFLE 521
>Q91287:FGFR3_PLEWA Fibroblast growth factor receptor 3 precursor - Pleurodeles waltlii| (Iberian ribbed newt) Length = 796 Score = 115 bits (287), Expect = 1e-24 Identities = 90/309 (29%), Positives = 150/309 (48%), Gaps = 30/309 (9%) Frame = +2 Query: 1871 WKLDKAKLLVGHSFASGAHSRLYR----GLYDDKP-----VAIKFIRRPHEDPGGIMAAK 2023 W+L +++L +G G ++ G+ DKP VA+K ++ D K Sbjct: 450 WELSRSRLTLGKPLGEGCFGQVVMADAVGIEKDKPNKATSVAVKMLKDDATD-------K 502 Query: 2024 LDKQYNTEINALSHL-YHKNVIKLV-ATHKCGPVYYIITELLPGGSLRSYLHN------- 2176 +E+ + + HKN+I L+ A + GP+Y ++ E G+LR YL Sbjct: 503 DLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLY-VLVEYASKGNLREYLRARRPPGMD 561 Query: 2177 --------PEHRPLPLERTISIALEIARGLEYVHSQGVVHRDIKPENILFDENFEVKIAD 2332 PE + L + +S A ++ARG+EY+ SQ +HRD+ N+L ++ +KIAD Sbjct: 562 YSFDTCKLPEEQ-LTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTDDNVMKIAD 620 Query: 2333 FGIAXXXXXXXXXXXXXG---TYRWMAPEMIKRKPYNRKVDVYSFGLLLWEMVT-GRIPF 2500 FG+A +WMAPE + + Y + DV+SFG+LLWE+ T G P+ Sbjct: 621 FGLARDVHNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPY 680 Query: 2501 ENLSPVQVAYAVATDKLKPMDPQDYCPAAVRPLIEQCCALQPEKRPDFWQLVKTLEKIQS 2680 + PV+ + + + + MD C + ++ +C P +RP F QLV+ L+++ + Sbjct: 681 PGI-PVEELFKLLKEGHR-MDKPANCTHELYMIMRECWHAVPSQRPTFKQLVEDLDRVLT 738 Query: 2681 VMSQGGSLD 2707 V S LD Sbjct: 739 VTSTDEYLD 747
>Q04912:RON_HUMAN Macrophage-stimulating protein receptor precursor - Homo sapiens| (Human) Length = 1400 Score = 114 bits (286), Expect = 2e-24 Identities = 67/214 (31%), Positives = 114/214 (53%), Gaps = 7/214 (3%) Frame = +2 Query: 2066 LYHKNVIKLVATHKCGP-VYYIITELLPGGSLRSYLHNPEHRPLPLERTISIALEIARGL 2242 L H NV+ L+ + +++ + G L ++ +P+ P ++ IS L++ARG+ Sbjct: 1138 LNHPNVLALIGIMLPPEGLPHVLLPYMCHGDLLQFIRSPQRNPT-VKDLISFGLQVARGM 1196 Query: 2243 EYVHSQGVVHRDIKPENILFDENFEVKIADFGIAXXXXXXXXXXXXXGTY-----RWMAP 2407 EY+ Q VHRD+ N + DE+F VK+ADFG+A + +WMA Sbjct: 1197 EYLAEQKFVHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARLPVKWMAL 1256 Query: 2408 EMIKRKPYNRKVDVYSFGLLLWEMVT-GRIPFENLSPVQVAYAVATDKLKPMDPQDYCPA 2584 E ++ + K DV+SFG+LLWE++T G P+ ++ P + + +A + P +YCP Sbjct: 1257 ESLQTYRFTTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQ--PEYCPD 1314 Query: 2585 AVRPLIEQCCALQPEKRPDFWQLVKTLEKIQSVM 2686 ++ +++QC P RP F LV +E+I S + Sbjct: 1315 SLYQVMQQCWEADPAVRPTFRVLVGEVEQIVSAL 1348
>Q05688:IGF1R_BOVIN Insulin-like growth factor 1 receptor precursor - Bos taurus (Bovine)| Length = 640 Score = 114 bits (286), Expect = 2e-24 Identities = 81/288 (28%), Positives = 136/288 (47%), Gaps = 21/288 (7%) Frame = +2 Query: 1868 DWKLDKAKLLVGHSFASGAHSRLY----RGLYDDKP---VAIKFIRRPHEDPGGIMAAKL 2026 +W++ + K+ + G+ +Y +G+ D+P VAIK + AA + Sbjct: 264 EWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNE---------AASM 314 Query: 2027 DK--QYNTEINALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYL--------HN 2176 + ++ E + + +V++L+ G +I EL+ G L+SYL +N Sbjct: 315 RERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENN 374 Query: 2177 PEHRPLPLERTISIALEIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIAXXXX 2356 P P L + I +A EIA G+ Y+++ VHRD+ N + E+F VKI DFG+ Sbjct: 375 PVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIY 434 Query: 2357 XXXXXXXXXG---TYRWMAPEMIKRKPYNRKVDVYSFGLLLWEMVT-GRIPFENLSPVQV 2524 RWM+PE +K + DV+SFG++LWE+ T P++ LS QV Sbjct: 435 ETDYYRKGGKGLLPVRWMSPESLKDGVFTTHSDVWSFGVVLWEIATLAEQPYQGLSNEQV 494 Query: 2525 AYAVATDKLKPMDPQDYCPAAVRPLIEQCCALQPEKRPDFWQLVKTLE 2668 V L +D D CP + L+ C P+ RP F +++ +++ Sbjct: 495 LRFVMEGGL--LDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSVK 540
>P50527:STE20_SCHPO Serine/threonine-protein kinase shk1/pak1 - Schizosaccharomyces pombe| (Fission yeast) Length = 658 Score = 114 bits (285), Expect = 2e-24 Identities = 111/454 (24%), Positives = 189/454 (41%), Gaps = 19/454 (4%) Frame = +2 Query: 1355 SKQKMSLEIPLSPPAKSEKSKAPRARSLVKSPSSMMLLSYLNKAYPNQGSSVQNADGSLH 1534 S+ K LE PP E ++ P + S S++ S+L SS Sbjct: 204 SQSKKYLEEGAKPPFPRESTEKP-----LLSVSALSSSSHLQPTSATSSSSRLYPSRPAP 258 Query: 1535 KPRSKSPLPSVVPSDTFREARASSQRFTSPPPKRVGSDKSVYGKSLGREQCDMAASPDWC 1714 P + S ++ S T + +++ R SP +D + R + +P Sbjct: 259 TPPASSSSSPLLSSQTVKTTTSNASRQPSPLVSSKSTDNII------RSHSPVLLTPQTL 312 Query: 1715 STPVVFGEHSSQKDSS-WTRRYFDNVGRRRVSAVENVRS-------RTVSMAQAVQSTVD 1870 ST +H +S+ + RR + + V+ + V + + Q+ S V Sbjct: 313 STSET--KHIRPNNSTPYQRRAETSTKPKAVATPQKVEAPSAPRLQKRAPRQQSNDSAVL 370 Query: 1871 WKLD-----KAKLLVGHSFAS---GAHSRLY--RGLYDDKPVAIKFIRRPHEDPGGIMAA 2020 KL K L+ +F GA +Y R + + VAIK + + + Sbjct: 371 AKLQSICNPKNPTLLYRNFVKIGQGASGDVYSARQVGTNLSVAIKKMNINQQPKKEFIV- 429 Query: 2021 KLDKQYNTEINALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPL 2200 EI + +HKN++ + T +++ E + GGSL + N L Sbjct: 430 -------NEILVMKSHHHKNIVNFIDTFFYKSELWMVMEYMRGGSLTEVVTN---NTLSE 479 Query: 2201 ERTISIALEIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGI-AXXXXXXXXXXX 2377 + +I E GL+++H G+VHRDIK +NIL ++K+ DFG A Sbjct: 480 GQIAAICKETLEGLQHLHENGIVHRDIKSDNILLSLQGDIKLTDFGFCAQIDSNMTKRTT 539 Query: 2378 XXGTYRWMAPEMIKRKPYNRKVDVYSFGLLLWEMVTGRIPFENLSPVQVAYAVATDKLKP 2557 GT WMAPE++ RK Y KVDV+S G++ EMV G P+ N +P++ Y +AT Sbjct: 540 MVGTPYWMAPEVVTRKEYGFKVDVWSLGIMAIEMVEGEPPYLNENPLRALYLIATIGTPK 599 Query: 2558 MDPQDYCPAAVRPLIEQCCALQPEKRPDFWQLVK 2659 + + + + + + P++RP +L++ Sbjct: 600 ISRPELLSSVFHDFLSKSLTVNPKQRPSSGELLR 633
>Q7RZD3:STE20_NEUCR Serine/threonine-protein kinase ste-20 - Neurospora crassa| Length = 954 Score = 114 bits (285), Expect = 2e-24 Identities = 62/206 (30%), Positives = 103/206 (50%), Gaps = 1/206 (0%) Frame = +2 Query: 2045 EINALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIAL 2224 EI + H N++ + ++ C +++ E + GGSL + + + S+ Sbjct: 719 EILVMKESSHPNIVNFIDSYLCAGELWVVMEYMEGGSLTDVV---TFNIMTEGQIASVCR 775 Query: 2225 EIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGI-AXXXXXXXXXXXXXGTYRWM 2401 E RGL+++HS+GV+HRDIK +NIL +K+ DFG A GT WM Sbjct: 776 ETLRGLQHLHSKGVIHRDIKSDNILLSMEGNIKLTDFGFCATINEAQSKRTTMVGTPYWM 835 Query: 2402 APEMIKRKPYNRKVDVYSFGLLLWEMVTGRIPFENLSPVQVAYAVATDKLKPMDPQDYCP 2581 APE++ RK Y RKVD++S G++ EM+ G P+ SP++ + +AT+ + + Sbjct: 836 APEVVTRKEYGRKVDIWSLGIMAIEMIEGEPPYLTESPLRALWLIATNGTPHIKDEQSLS 895 Query: 2582 AAVRPLIEQCCALQPEKRPDFWQLVK 2659 R + + PEKR L++ Sbjct: 896 PVFRDFLYFALKVDPEKRASAHDLLR 921
>P25911:LYN_MOUSE Tyrosine-protein kinase Lyn - Mus musculus (Mouse)| Length = 512 Score = 114 bits (285), Expect = 2e-24 Identities = 75/270 (27%), Positives = 131/270 (48%), Gaps = 4/270 (1%) Frame = +2 Query: 1871 WKLDKAKLLVGHSFASGAHSRLYRGLYDDKP-VAIKFIRRPHEDPGGIMAAKLDKQYNTE 2047 W++ + + + +G ++ G Y++ VA+K ++ PG + + + E Sbjct: 240 WEIPRESIKLVKKLGAGQFGEVWMGYYNNSTKVAVKTLK-----PGTMSV----QAFLEE 290 Query: 2048 INALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIALE 2227 N + L H +++L A YIITE + GSL +L + E + L + I + + Sbjct: 291 ANLMKTLQHDKLVRLYAVVTKEEPIYIITEFMAKGSLLDFLKSDEGGKVLLPKLIDFSAQ 350 Query: 2228 IARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIAXXXXXXXXXXXXXGTY--RWM 2401 IA G+ Y+ + +HRD++ N+L E+ KIADFG+A + +W Sbjct: 351 IAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWT 410 Query: 2402 APEMIKRKPYNRKVDVYSFGLLLWEMVT-GRIPFENLSPVQVAYAVATDKLKPMDPQDYC 2578 APE I + K DV+SFG+LL+E+VT G+IP+ + V A++ P + C Sbjct: 411 APEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMSALSQGYRMPR--MENC 468 Query: 2579 PAAVRPLIEQCCALQPEKRPDFWQLVKTLE 2668 P + +++ C + E+RP F L L+ Sbjct: 469 PDELYDIMKMCWKEKAEERPTFDYLQSVLD 498
>Q8QFP8:LIMK1_CHICK LIM domain kinase 1 - Gallus gallus (Chicken)| Length = 662 Score = 114 bits (285), Expect = 2e-24 Identities = 75/257 (29%), Positives = 118/257 (45%), Gaps = 24/257 (9%) Frame = +2 Query: 1979 IRRPHEDPGGIMAAK--------LDKQYNTEINALSHLYHKNVIKLVATHKCGPVYYIIT 2134 I+ H + G +M K + + E+ + L H NV+K + IT Sbjct: 361 IKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGVLYKEKRLNFIT 420 Query: 2135 ELLPGGSLRSYLHNPEHRPLPLERTISIALEIARGLEYVHSQGVVHRDIKPENILFDENF 2314 E + GG+LR + + + P + +S A +IA G+ Y+HS ++HRD+ N L EN Sbjct: 421 EYIKGGTLRGLIKSMDSH-YPWSQRVSFAKDIAAGMAYLHSMNIIHRDLNSHNCLVRENK 479 Query: 2315 EVKIADFGIA---------------XXXXXXXXXXXXXGTYRWMAPEMIKRKPYNRKVDV 2449 V +ADFG+A G WMAPEMI + Y+ KVD+ Sbjct: 480 SVVVADFGLARLMVDEKNQPEHLQNLKKPDRKKRYTVVGNPYWMAPEMINGRSYDEKVDI 539 Query: 2450 YSFGLLLWEMVTGRIPFE-NLSPVQVAYAVATDKLKPMDPQDYCPAAVRPLIEQCCALQP 2626 +SFG++L E++ GR+ + + P + + CP + P+ CC L P Sbjct: 540 FSFGIVLCEII-GRVSADPDYLPRTTDFGLNVRGFLERYCPPACPPSFFPIAACCCDLDP 598 Query: 2627 EKRPDFWQLVKTLEKIQ 2677 EKRP F +L + LE ++ Sbjct: 599 EKRPSFSKLEQWLETLR 615
>Q62844:FYN_RAT Proto-oncogene tyrosine-protein kinase Fyn - Rattus norvegicus (Rat)| Length = 537 Score = 114 bits (285), Expect = 2e-24 Identities = 80/270 (29%), Positives = 128/270 (47%), Gaps = 4/270 (1%) Frame = +2 Query: 1871 WKLDKAKLLVGHSFASGAHSRLYRGLYD-DKPVAIKFIRRPHEDPGGIMAAKLDKQYNTE 2047 W++ + L + +G ++ G ++ + VAIK ++ P + + E Sbjct: 264 WEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSP---------ESFLEE 314 Query: 2048 INALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIALE 2227 + L H +++L A P+Y I+TE + GSL +L + E R L L + +A + Sbjct: 315 AQIMKKLKHDKLVQLYAVVSEEPIY-IVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQ 373 Query: 2228 IARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIAXXXXXXXXXXXXXGTY--RWM 2401 +A G+ Y+ +HRD++ NIL KIADFG+A + +W Sbjct: 374 VAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWT 433 Query: 2402 APEMIKRKPYNRKVDVYSFGLLLWEMVT-GRIPFENLSPVQVAYAVATDKLKPMDPQDYC 2578 APE + K DV+SFG+LL E+VT GR+P+ ++ +V V P PQD C Sbjct: 434 APEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPC-PQD-C 491 Query: 2579 PAAVRPLIEQCCALQPEKRPDFWQLVKTLE 2668 P ++ L+ C PE+RP F L LE Sbjct: 492 PISLHELMIHCWKKDPEERPTFEYLQGFLE 521
>A1Y2K1:FYN_PIG Proto-oncogene tyrosine-protein kinase Fyn - Sus scrofa (Pig)| Length = 537 Score = 114 bits (285), Expect = 2e-24 Identities = 80/270 (29%), Positives = 128/270 (47%), Gaps = 4/270 (1%) Frame = +2 Query: 1871 WKLDKAKLLVGHSFASGAHSRLYRGLYD-DKPVAIKFIRRPHEDPGGIMAAKLDKQYNTE 2047 W++ + L + +G ++ G ++ + VAIK ++ P + + E Sbjct: 264 WEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSP---------ESFLEE 314 Query: 2048 INALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIALE 2227 + L H +++L A P+Y I+TE + GSL +L + E R L L + +A + Sbjct: 315 AQIMKKLKHDKLVQLYAVVSEEPIY-IVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQ 373 Query: 2228 IARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIAXXXXXXXXXXXXXGTY--RWM 2401 +A G+ Y+ +HRD++ NIL KIADFG+A + +W Sbjct: 374 VAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWT 433 Query: 2402 APEMIKRKPYNRKVDVYSFGLLLWEMVT-GRIPFENLSPVQVAYAVATDKLKPMDPQDYC 2578 APE + K DV+SFG+LL E+VT GR+P+ ++ +V V P PQD C Sbjct: 434 APEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPC-PQD-C 491 Query: 2579 PAAVRPLIEQCCALQPEKRPDFWQLVKTLE 2668 P ++ L+ C PE+RP F L LE Sbjct: 492 PISLHELMIHCWKKDPEERPTFEYLQGFLE 521
>P39688:FYN_MOUSE Proto-oncogene tyrosine-protein kinase Fyn - Mus musculus (Mouse)| Length = 537 Score = 114 bits (285), Expect = 2e-24 Identities = 80/270 (29%), Positives = 128/270 (47%), Gaps = 4/270 (1%) Frame = +2 Query: 1871 WKLDKAKLLVGHSFASGAHSRLYRGLYD-DKPVAIKFIRRPHEDPGGIMAAKLDKQYNTE 2047 W++ + L + +G ++ G ++ + VAIK ++ P + + E Sbjct: 264 WEIPRESLQLIKRLGNGQFGEVWLGTWNGNTKVAIKTLKPGTMSP---------ESFLEE 314 Query: 2048 INALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIALE 2227 + L H +++L A P+Y I+TE + GSL +L + E R L L + +A + Sbjct: 315 AQIMKKLKHDKLVQLYAVVSEEPIY-IVTEYMSKGSLLDFLKDGEGRALKLPNLVDMAAQ 373 Query: 2228 IARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIAXXXXXXXXXXXXXGTY--RWM 2401 +A G+ Y+ +HRD++ NIL KIADFG+A + +W Sbjct: 374 VAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWT 433 Query: 2402 APEMIKRKPYNRKVDVYSFGLLLWEMVT-GRIPFENLSPVQVAYAVATDKLKPMDPQDYC 2578 APE + K DV+SFG+LL E+VT GR+P+ ++ +V V P PQD C Sbjct: 434 APEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPC-PQD-C 491 Query: 2579 PAAVRPLIEQCCALQPEKRPDFWQLVKTLE 2668 P ++ L+ C PE+RP F L LE Sbjct: 492 PISLHELMIHCWKKDPEERPTFEYLQGFLE 521
>A0JNB0:FYN_BOVIN Proto-oncogene tyrosine-protein kinase Fyn - Bos taurus (Bovine)| Length = 537 Score = 114 bits (285), Expect = 2e-24 Identities = 80/270 (29%), Positives = 128/270 (47%), Gaps = 4/270 (1%) Frame = +2 Query: 1871 WKLDKAKLLVGHSFASGAHSRLYRGLYD-DKPVAIKFIRRPHEDPGGIMAAKLDKQYNTE 2047 W++ + L + +G ++ G ++ + VAIK ++ P + + E Sbjct: 264 WEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSP---------ESFLEE 314 Query: 2048 INALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIALE 2227 + L H +++L A P+Y I+TE + GSL +L + E R L L + +A + Sbjct: 315 AQIMKKLKHDKLVQLYAVVSEEPIY-IVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQ 373 Query: 2228 IARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIAXXXXXXXXXXXXXGTY--RWM 2401 +A G+ Y+ +HRD++ NIL KIADFG+A + +W Sbjct: 374 VAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWT 433 Query: 2402 APEMIKRKPYNRKVDVYSFGLLLWEMVT-GRIPFENLSPVQVAYAVATDKLKPMDPQDYC 2578 APE + K DV+SFG+LL E+VT GR+P+ ++ +V V P PQD C Sbjct: 434 APEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPC-PQD-C 491 Query: 2579 PAAVRPLIEQCCALQPEKRPDFWQLVKTLE 2668 P ++ L+ C PE+RP F L LE Sbjct: 492 PISLHELMIHCWKKDPEERPTFEYLQGFLE 521
>Q498D6:FGFR4_RAT Fibroblast growth factor receptor 4 precursor - Rattus norvegicus| (Rat) Length = 800 Score = 114 bits (285), Expect = 2e-24 Identities = 81/301 (26%), Positives = 142/301 (47%), Gaps = 27/301 (8%) Frame = +2 Query: 1871 WKLDKAKLLVGHSFASGAHSRLYR----GLYDDKP-----VAIKFIRRPHEDPGGIMAAK 2023 W+ + +L++G G ++ R G+ +P VA+K ++ D +A Sbjct: 458 WEFPRDRLVLGKPLGEGCFGQVVRAEALGMDSSRPDQTSTVAVKMLKDNASDKD--LADL 515 Query: 2024 LDKQYNTEINALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLH---------- 2173 + + ++ HKN+I L+ Y+I E G+LR +L Sbjct: 516 ISEMEMMKLIGR----HKNIINLLGVCTQEGPLYVIVEYAAKGNLREFLRARRPPGPDLS 571 Query: 2174 ----NPEHRPLPLERTISIALEIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGI 2341 PL +S A ++ARG++Y+ S+ +HRD+ N+L E+ +KIADFG+ Sbjct: 572 PDGPRSSEGPLSFPALVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDDVMKIADFGL 631 Query: 2342 AXXXXXXXXXXXXXG---TYRWMAPEMIKRKPYNRKVDVYSFGLLLWEMVT-GRIPFENL 2509 A +WMAPE + + Y + DV+SFG+LLWE+ T G P+ + Sbjct: 632 ARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGI 691 Query: 2510 SPVQVAYAVATDKLKPMDPQDYCPAAVRPLIEQCCALQPEKRPDFWQLVKTLEKIQSVMS 2689 PV+ +++ + + M+ CP+ + L+ +C P +RP F QLV+ L+K+ +S Sbjct: 692 -PVEELFSLLREGHR-MERPPNCPSELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVS 749 Query: 2690 Q 2692 + Sbjct: 750 E 750
>P42690:SRK4_SPOLA Tyrosine-protein kinase isoform SRK4 - Spongilla lacustris| (Freshwater sponge) Length = 506 Score = 114 bits (284), Expect = 3e-24 Identities = 79/291 (27%), Positives = 135/291 (46%), Gaps = 4/291 (1%) Frame = +2 Query: 1856 QSTVDWKLDKAKLLVGHSFASGAHSRLYRGLYDDKP-VAIKFIRRPHEDPGGIMAAKLDK 2032 Q+ +W+++K ++ + +G ++ GL++ VA+K ++ PG + + Sbjct: 228 QANEEWEIEKKQIKLLRGLGAGQFGEVWEGLWNGTTSVAVKTLK-----PGTMSI----E 278 Query: 2033 QYNTEINALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTI 2212 ++ E + + L H +I+L A YI+TEL+ GSL YL + R L L + Sbjct: 279 EFLEEASIMKQLRHPKLIQLYAVCTKEEPIYIVTELMKHGSLLEYLRG-DGRSLKLPDLV 337 Query: 2213 SIALEIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIAXXXXXXXXXXXXXGTY 2392 + ++A G+ Y+ Q +HRD+ NIL E+ K+ADFG+A + Sbjct: 338 DMCSQVASGMSYLEQQNYIHRDLAARNILVGEHKICKVADFGLARVIDEEIYEAKLGAKF 397 Query: 2393 --RWMAPEMIKRKPYNRKVDVYSFGLLLWEMVT-GRIPFENLSPVQVAYAVATDKLKPMD 2563 +W APE + K DV+SFG++L+E++T GR P+ ++ QV + P Sbjct: 398 PIKWTAPEAAMYSRFTIKSDVWSFGIVLYEVITYGRFPYPGMTNAQVLEQIQQSYRMPRP 457 Query: 2564 PQDYCPAAVRPLIEQCCALQPEKRPDFWQLVKTLEKIQSVMSQGGSLDTLR 2716 CP + ++ C P RP F L LE+ + G D R Sbjct: 458 MG--CPEKLYAIMMDCWREDPASRPTFETLSWQLEEFFTTGDDAGYKDMER 506
>Q8XJL8:PKN2_CLOPE Probable serine/threonine protein kinase CPE1738 - Clostridium| perfringens Length = 685 Score = 114 bits (284), Expect = 3e-24 Identities = 74/242 (30%), Positives = 125/242 (51%), Gaps = 4/242 (1%) Frame = +2 Query: 1964 VAIKFIRRPHEDPGGIMAAKLDKQYNTEINALSHLYHKNVIKLVATHKCGPVYYIITELL 2143 VA+K ++ ++ I+ +++ E A+++L + NV+ ++ + YI+ E + Sbjct: 36 VAVKILKDEFKNNEEIV-----RRFKKEATAIANLSNPNVVNVLDVGTQDDINYIVMEYV 90 Query: 2144 PGGSLRSYLHNPEHRPLPLERTISIALEIARGLEYVHSQGVVHRDIKPENILFDENFEVK 2323 G +L+ + E LP E ISI +++A+ LE H G++HRD+KP+NIL E VK Sbjct: 91 EGKTLKDIIK--EKGALPYEVAISIGIKVAKALECAHKSGIIHRDVKPQNILVTEEGVVK 148 Query: 2324 IADFGIA--XXXXXXXXXXXXXGTYRWMAPEMIKRKPYNRKVDVYSFGLLLWEMVTGRIP 2497 + DFGIA G+ + +PE K + + D+YS G++L+EMVTG +P Sbjct: 149 VTDFGIAKSMDSSTIAHTNSVMGSAHYFSPEQAKGTYTDYRTDLYSLGIVLYEMVTGVVP 208 Query: 2498 FENLSPVQVAYAVATDK-LKPMDPQDYCPAAVRPLIEQCCALQPEKR-PDFWQLVKTLEK 2671 F SPV VA +K + P + P ++ LI + P R +++ LEK Sbjct: 209 FNGDSPVTVAVKHIQEKAIPPKNINQNIPNSLNDLIMKAMEKDPVNRYQTAKEIIGDLEK 268 Query: 2672 IQ 2677 I+ Sbjct: 269 IK 270
>Q90Z00:FGFR1_DANRE Basic fibroblast growth factor receptor 1 precursor - Danio rerio| (Zebrafish) (Brachydanio rerio) Length = 806 Score = 114 bits (284), Expect = 3e-24 Identities = 88/311 (28%), Positives = 152/311 (48%), Gaps = 32/311 (10%) Frame = +2 Query: 1871 WKLDKAKLLVGHSFASGAHSRLYR----GLYDDKP-----VAIKFIRRPHEDPGGIMAAK 2023 W++ + +L++G G ++ G+ +KP VA+K ++ + Sbjct: 454 WEVQRDRLVLGKPLGEGCFGQVMMAEAMGMDKEKPNRITKVAVKMLK----------SDA 503 Query: 2024 LDKQYNTEINALSHLY----HKNVIKLV-ATHKCGPVYYIITELLPGGSLRSYL------ 2170 +K + I+ + + HKN+I L+ A + GP+Y +I E G+LR YL Sbjct: 504 TEKDLSDLISEMEMMKIIGKHKNIINLLGACTQDGPLY-VIVEFAAKGNLREYLRVRRPP 562 Query: 2171 -----HNPEHRP---LPLERTISIALEIARGLEYVHSQGVVHRDIKPENILFDENFEVKI 2326 +NP+ P + ++ +S A ++ARG+EY+ S+ +HRD+ N+L E+ +KI Sbjct: 563 GMEYCYNPDQVPVENMSIKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKI 622 Query: 2327 ADFGIAXXXXXXXXXXXXXG---TYRWMAPEMIKRKPYNRKVDVYSFGLLLWEMVT-GRI 2494 ADFG+A +WMAPE + + Y + DV+SFG+LLWE+ T G Sbjct: 623 ADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGS 682 Query: 2495 PFENLSPVQVAYAVATDKLKPMDPQDYCPAAVRPLIEQCCALQPEKRPDFWQLVKTLEKI 2674 P+ + PV+ + + + + MD C + ++ C P +RP F QLV+ L++ Sbjct: 683 PYPGV-PVEELFKLLKEGHR-MDRPSTCTHELYMMMRDCWHAVPSQRPTFKQLVEDLDRT 740 Query: 2675 QSVMSQGGSLD 2707 S+ S LD Sbjct: 741 LSMTSNQEYLD 751
>P00542:FES_FSVGA Tyrosine-protein kinase transforming protein Fes - Feline sarcoma| virus (strain Gardner-Arnstein) (Ga-FeSV) (Gardner-Arnstein feline leukemia oncovirus B) Length = 609 Score = 114 bits (284), Expect = 3e-24 Identities = 83/278 (29%), Positives = 132/278 (47%), Gaps = 9/278 (3%) Frame = +2 Query: 1871 WKLDKAKLLVGHSFASGAHSRLYRGLY--DDKPVAIKFIRR---PHEDPGGIMAAKLDKQ 2035 W L+ L++G G ++ G D+ VA+K R P + AK+ KQ Sbjct: 341 WVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDIKAKFLQEAKILKQ 400 Query: 2036 YNTEINALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTIS 2215 Y+ H N+++L+ YI+ EL+ GG ++L R L ++ + Sbjct: 401 YS----------HPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGAR-LRMKTLLQ 449 Query: 2216 IALEIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGI---AXXXXXXXXXXXXXG 2386 + + A G+EY+ S+ +HRD+ N L E +KI+DFG+ A Sbjct: 450 MVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREAADGIYAASGGLRQV 509 Query: 2387 TYRWMAPEMIKRKPYNRKVDVYSFGLLLWEMVT-GRIPFENLSPVQVAYAVATDKLKPMD 2563 +W APE + Y+ + DV+SFG+LLWE + G P+ NLS Q V +K + Sbjct: 510 PVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFV--EKGGRLP 567 Query: 2564 PQDYCPAAVRPLIEQCCALQPEKRPDFWQLVKTLEKIQ 2677 + CP AV L+EQC A +P +RP F + + L+ I+ Sbjct: 568 CPELCPDAVFRLMEQCWAYEPGQRPSFSAIYQELQSIR 605
>P16591:FER_HUMAN Proto-oncogene tyrosine-protein kinase FER - Homo sapiens (Human)| Length = 822 Score = 114 bits (284), Expect = 3e-24 Identities = 78/273 (28%), Positives = 130/273 (47%), Gaps = 4/273 (1%) Frame = +2 Query: 1871 WKLDKAKLLVGHSFASGAHSRLYRGLYDDKP-VAIKFIRRPHEDPGGIMAAKLDKQYNTE 2047 W L +++G G +Y+G DK VA+K + ED + +L ++ E Sbjct: 556 WILSHEDVILGELLGKGNFGEVYKGTLKDKTSVAVKTCK---ED----LPQELKIKFLQE 608 Query: 2048 INALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIALE 2227 L H N++KL+ YII EL+ GG ++L + L L++ + +L+ Sbjct: 609 AKILKQYDHPNIVKLIGVCTQRQPVYIIMELVSGGDFLTFLRRKKDE-LKLKQLVKFSLD 667 Query: 2228 IARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIAXXXXXXXXXXXXXG--TYRWM 2401 A G+ Y+ S+ +HRD+ N L EN +KI+DFG++ +W Sbjct: 668 AAAGMLYLESKNCIHRDLAARNCLVGENNVLKISDFGMSRQEDGGVYSSSGLKQIPIKWT 727 Query: 2402 APEMIKRKPYNRKVDVYSFGLLLWEMVT-GRIPFENLSPVQVAYAVATDKLKPMDPQDYC 2578 APE + Y+ + DV+SFG+LLWE + G P+ ++ Q V ++ M +C Sbjct: 728 APEALNYGRYSSESDVWSFGILLWETFSLGVCPYPGMTNQQAREQV--ERGYRMSAPQHC 785 Query: 2579 PAAVRPLIEQCCALQPEKRPDFWQLVKTLEKIQ 2677 P + ++ +C +PE RP F +L K L I+ Sbjct: 786 PEDISKIMMKCWDYKPENRPKFSELQKELTIIK 818
>O14427:CLA4_CANAL Serine/threonine-protein kinase CLA4 - Candida albicans (Yeast)| Length = 971 Score = 114 bits (284), Expect = 3e-24 Identities = 62/207 (29%), Positives = 109/207 (52%), Gaps = 2/207 (0%) Frame = +2 Query: 2045 EINALSHLYHKNVIKLVATHKCGP-VYYIITELLPGGSLRSYLHNPEHRPLPLERTISIA 2221 EI + HKN++ + ++ G ++I E + GGSL + N + + L ++ +I Sbjct: 726 EILVMKDSQHKNIVNFLDSYLIGDNELWVIMEYMQGGSLTEIIENNDFK-LNEKQIATIC 784 Query: 2222 LEIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGI-AXXXXXXXXXXXXXGTYRW 2398 E +GL+++H + ++HRDIK +N+L D VKI DFG A GT W Sbjct: 785 FETLKGLQHLHKKHIIHRDIKSDNVLLDAYGNVKITDFGFCAKLTDQRNKRATMVGTPYW 844 Query: 2399 MAPEMIKRKPYNRKVDVYSFGLLLWEMVTGRIPFENLSPVQVAYAVATDKLKPMDPQDYC 2578 MAPE++K+K Y+ KVDV+S G++ EM+ G P+ N P++ Y +AT+ + + Sbjct: 845 MAPEVVKQKEYDEKVDVWSLGIMTIEMIEGEPPYLNEEPLKALYLIATNGTPKLKKPELL 904 Query: 2579 PAAVRPLIEQCCALQPEKRPDFWQLVK 2659 +++ + C + R +L++ Sbjct: 905 SNSIKKFLSICLCVDVRYRASTDELLE 931 Score = 33.1 bits (74), Expect = 7.1 Identities = 28/120 (23%), Positives = 52/120 (43%), Gaps = 12/120 (10%) Frame = +2 Query: 1337 PNEKKASK---QKMSLEIPLSPPAKSEKSKAPRARSLVKSPSSMMLLSYLNKAY------ 1489 PN ++K Q+ +L+ + PPAKS S+ +R+ K P+ L ++ Sbjct: 317 PNNYSSTKNNVQEANLQEWVKPPAKSTVSQFKPSRAAPKPPTPYHLTQLNGSSHQHTSSS 376 Query: 1490 ---PNQGSSVQNADGSLHKPRSKSPLPSVVPSDTFREARASSQRFTSPPPKRVGSDKSVY 1660 P+ G++ N + + ++ SPL +++ AR +PPP G+ Y Sbjct: 377 GSLPSSGNNNNNNSTNNNNTKNVSPLNNLMNKSELIPAR------RAPPPPTSGTSSDTY 430
>Q6C3D7:STE20_YARLI Serine/threonine-protein kinase STE20 - Yarrowia lipolytica (Candida| lipolytica) Length = 1125 Score = 113 bits (283), Expect = 4e-24 Identities = 82/306 (26%), Positives = 139/306 (45%), Gaps = 15/306 (4%) Frame = +2 Query: 1787 VGRRRVSAVENVRSRTVSMAQAVQSTVDWKLDKAKLLVGHS---FASGAHSRLYRGLYDD 1957 VG S+ + V S + A A Q + +L K + +V G ++LYR L Sbjct: 791 VGGPVTSSTQQVLSNPAAAAAASQRKREQRLRKDQQVVARLNQICTPGDPTKLYRNLVKI 850 Query: 1958 KPVAIKFIRRPHEDPGGIMAAKLDKQYN-----------TEINALSHLYHKNVIKLVATH 2104 A + +E + A KQ N EI + HKN++ + ++ Sbjct: 851 GQGASGGVFTAYEVGSNLSVAI--KQMNLEHQPKKELIINEILVMKDSKHKNIVNFIDSY 908 Query: 2105 KCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIALEIARGLEYVHSQGVVHRDIK 2284 G +++ E + GGSL + + + + ++ E GL+++HS+GV+HRDIK Sbjct: 909 LHGGDLWVVMEYMEGGSLTDVV---TYNMMTESQIGAVCRETLLGLQHLHSKGVIHRDIK 965 Query: 2285 PENILFDENFEVKIADFGI-AXXXXXXXXXXXXXGTYRWMAPEMIKRKPYNRKVDVYSFG 2461 +N+L E+K+ DFG A GT WMAPE++ RK Y KVD++S G Sbjct: 966 SDNVLLSMRGEIKLTDFGFCAQINESNLKRTTMVGTPYWMAPEVVSRKEYGSKVDIWSLG 1025 Query: 2462 LLLWEMVTGRIPFENLSPVQVAYAVATDKLKPMDPQDYCPAAVRPLIEQCCALQPEKRPD 2641 ++ EM+ G P+ N SP++ Y +AT+ + D + + + ++R Sbjct: 1026 IMSIEMIEGEPPYLNESPLRALYLIATNGTPQLKEPDALSTIFKAFLAWALQVSADQRAS 1085 Query: 2642 FWQLVK 2659 +L+K Sbjct: 1086 ASELLK 1091
>P18460:FGFR3_CHICK Fibroblast growth factor receptor 3 precursor - Gallus gallus| (Chicken) Length = 806 Score = 113 bits (283), Expect = 4e-24 Identities = 90/309 (29%), Positives = 150/309 (48%), Gaps = 30/309 (9%) Frame = +2 Query: 1871 WKLDKAKLLVGHSFASGAHSRLYR----GLYDDKP-----VAIKFIRRPHEDPGGIMAAK 2023 W+L +++L +G G ++ G+ DKP VA+K ++ D K Sbjct: 459 WELARSRLTLGKPLGEGCFGQVVMAEAIGIDKDKPNKAITVAVKMLKDDATD-------K 511 Query: 2024 LDKQYNTEINALSHL-YHKNVIKLV-ATHKCGPVYYIITELLPGGSLRSYLHN------- 2176 +E+ + + HKN+I L+ A + GP+Y ++ E G+LR YL Sbjct: 512 DLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLY-VLVEYASKGNLREYLRARRPPGMD 570 Query: 2177 --------PEHRPLPLERTISIALEIARGLEYVHSQGVVHRDIKPENILFDENFEVKIAD 2332 PE + L + +S A ++ARG+EY+ SQ +HRD+ N+L E+ +KIAD Sbjct: 571 YSFDTCKLPEEQ-LTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIAD 629 Query: 2333 FGIAXXXXXXXXXXXXXG---TYRWMAPEMIKRKPYNRKVDVYSFGLLLWEMVT-GRIPF 2500 FG+A +WMAPE + + Y + DV+SFG+LLWE+ T G P+ Sbjct: 630 FGLARDVHNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPY 689 Query: 2501 ENLSPVQVAYAVATDKLKPMDPQDYCPAAVRPLIEQCCALQPEKRPDFWQLVKTLEKIQS 2680 + PV+ + + + + MD C + ++ +C P +RP F QLV+ L+++ + Sbjct: 690 PGI-PVEELFKLLKEGHR-MDKPANCTHDLYMIMRECWHAVPSQRPTFKQLVEDLDRVLT 747 Query: 2681 VMSQGGSLD 2707 + S LD Sbjct: 748 MTSTDEYLD 756
>Q91285:FGFR1_PLEWA Fibroblast growth factor receptor 1 precursor - Pleurodeles waltlii| (Iberian ribbed newt) Length = 816 Score = 113 bits (283), Expect = 4e-24 Identities = 90/311 (28%), Positives = 150/311 (48%), Gaps = 32/311 (10%) Frame = +2 Query: 1871 WKLDKAKLLVGHSFASGAHSRLYRG----LYDDKP-----VAIKFIRRPHEDPGGIMAAK 2023 W+ + +L++G G ++ G L +KP VA+K ++ + Sbjct: 467 WEFSRDRLILGKPLGEGCFGQVVMGEAIGLDKEKPNRVTKVAVKMLK----------SDA 516 Query: 2024 LDKQYNTEINALSHLY----HKNVIKLV-ATHKCGPVYYIITELLPGGSLRSYL------ 2170 +K + I+ + + HKN+I L+ A + GP+Y +I E G+LR YL Sbjct: 517 TEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLY-VIVEYASKGNLREYLRARRPP 575 Query: 2171 -----HNPEHRP---LPLERTISIALEIARGLEYVHSQGVVHRDIKPENILFDENFEVKI 2326 +NP H L + +S A ++ARG+EY+ S+ +HRD+ N+L E+ +KI Sbjct: 576 GMEYCYNPIHVSKDMLSFKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDSVMKI 635 Query: 2327 ADFGIAXXXXXXXXXXXXXG---TYRWMAPEMIKRKPYNRKVDVYSFGLLLWEMVT-GRI 2494 ADFG+A +WMAPE + + Y + DV+SFG+LLWE+ T G Sbjct: 636 ADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGS 695 Query: 2495 PFENLSPVQVAYAVATDKLKPMDPQDYCPAAVRPLIEQCCALQPEKRPDFWQLVKTLEKI 2674 P+ + PV+ + + + + MD C + ++ C P +RP F QLV+ L++I Sbjct: 696 PYPGV-PVEELFKLLKEGHR-MDKPGNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRI 753 Query: 2675 QSVMSQGGSLD 2707 ++ S LD Sbjct: 754 VAMTSNQEYLD 764
>P16879:FES_MOUSE Proto-oncogene tyrosine-protein kinase Fes/Fps - Mus musculus (Mouse)| Length = 820 Score = 113 bits (283), Expect = 4e-24 Identities = 82/278 (29%), Positives = 131/278 (47%), Gaps = 9/278 (3%) Frame = +2 Query: 1871 WKLDKAKLLVGHSFASGAHSRLYRGLY--DDKPVAIKFIRR---PHEDPGGIMAAKLDKQ 2035 W L L++G G ++ G D+ PVA+K R P + A++ KQ Sbjct: 552 WVLKHEDLVLGEQIGRGNFGEVFSGRLRADNTPVAVKSCRETLPPDLKAKFLQEARILKQ 611 Query: 2036 YNTEINALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTIS 2215 YN H N+++L+ YI+ EL+ GG ++L R L ++ + Sbjct: 612 YN----------HPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGAR-LRVKTLLQ 660 Query: 2216 IALEIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIA---XXXXXXXXXXXXXG 2386 + + A G+EY+ S+ +HRD+ N L E +KI+DFG++ Sbjct: 661 MMGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGIYAACSGLRQV 720 Query: 2387 TYRWMAPEMIKRKPYNRKVDVYSFGLLLWEMVT-GRIPFENLSPVQVAYAVATDKLKPMD 2563 +W APE + Y+ + DV+SFG+LLWE + G P+ NL+ Q V +K + Sbjct: 721 PVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLTNQQTREFV--EKGHRLP 778 Query: 2564 PQDYCPAAVRPLIEQCCALQPEKRPDFWQLVKTLEKIQ 2677 + CP AV L+EQC A +P +RP F + + L I+ Sbjct: 779 CPELCPDAVFRLMEQCWAYEPGQRPSFSIICQELHSIR 816
>P05986:KAPC_YEAST cAMP-dependent protein kinase type 3 - Saccharomyces cerevisiae| (Baker's yeast) Length = 398 Score = 113 bits (282), Expect = 5e-24 Identities = 86/313 (27%), Positives = 144/313 (46%) Frame = +2 Query: 1616 TSPPPKRVGSDKSVYGKSLGREQCDMAASPDWCSTPVVFGEHSSQKDSSWTRRYFDNVGR 1795 T P VG D V S+ E+C +TPV +S G+ Sbjct: 20 TETTPDNVGQDIPVNAHSV-HEECSS-------NTPVEINGRNS--------------GK 57 Query: 1796 RRVSAVENVRSRTVSMAQAVQSTVDWKLDKAKLLVGHSFASGAHSRLYRGLYDDKPVAIK 1975 + A + M Q ++ + L ++L S L R ++ + A+K Sbjct: 58 LKEEASAGICLVKKPMLQYRDTSGKYSLSDFQILRTLGTGSFGRVHLIRSNHNGRFYALK 117 Query: 1976 FIRRPHEDPGGIMAAKLDKQYNTEINALSHLYHKNVIKLVATHKCGPVYYIITELLPGGS 2155 +++ I+ K + N E LS + H +I++ T + +++ + + GG Sbjct: 118 TLKKHT-----IVKLKQVEHTNDERRMLSIVSHPFIIRMWGTFQDSQQVFMVMDYIEGGE 172 Query: 2156 LRSYLHNPEHRPLPLERTISIALEIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADF 2335 L S L + P P+ + A E+ LEY+HS+ +++RD+KPENIL D+N +KI DF Sbjct: 173 LFSLLRKSQRFPNPVAKFY--AAEVCLALEYLHSKDIIYRDLKPENILLDKNGHIKITDF 230 Query: 2336 GIAXXXXXXXXXXXXXGTYRWMAPEMIKRKPYNRKVDVYSFGLLLWEMVTGRIPFENLSP 2515 G A GT ++APE++ KPYN+ VD +SFG+L++EM+ G PF N + Sbjct: 231 GFA--KYVPDVTYTLCGTPDYIAPEVVSTKPYNKSVDWWSFGVLIYEMLAGYTPFYNSNT 288 Query: 2516 VQVAYAVATDKLK 2554 ++ + +LK Sbjct: 289 MKTYENILNAELK 301
>P10447:ABL_FSVHY Tyrosine-protein kinase transforming protein Abl - Feline sarcoma| virus (strain Hardy-Zuckerman 2) Length = 439 Score = 113 bits (282), Expect = 5e-24 Identities = 70/266 (26%), Positives = 127/266 (47%), Gaps = 5/266 (1%) Frame = +2 Query: 1871 WKLDKAKLLVGHSFASGAHSRLYRGLYD--DKPVAIKFIRRPHEDPGGIMAAKLDKQYNT 2044 W++++ + + H G + +Y G++ VA+K ++ ED + +++ Sbjct: 184 WEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLK---EDTMEV------EEFLK 234 Query: 2045 EINALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIAL 2224 E + + H N+++L+ P +YIITE + G+L YL + + + +A Sbjct: 235 EAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMAT 294 Query: 2225 EIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIAXXXXXXXXXXXXXGTY--RW 2398 +I+ +EY+ + +HRD+ N L EN VK+ADFG++ + +W Sbjct: 295 QISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGTKFPIKW 354 Query: 2399 MAPEMIKRKPYNRKVDVYSFGLLLWEMVT-GRIPFENLSPVQVAYAVATDKLKPMDPQDY 2575 APE + ++ K DV++FG+LLWE+ T G P+ + QV + D M+ + Sbjct: 355 TAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKD--YRMERPEG 412 Query: 2576 CPAAVRPLIEQCCALQPEKRPDFWQL 2653 CP V L+ C P RP F ++ Sbjct: 413 CPEKVYELMRACWQWNPSDRPAFAEI 438
>Q7Z8E9:STE20_MAGGR Serine/threonine-protein kinase MST20 - Magnaporthe grisea (Rice| blast fungus) (Pyricularia grisea) Length = 914 Score = 112 bits (281), Expect = 7e-24 Identities = 61/206 (29%), Positives = 103/206 (50%), Gaps = 1/206 (0%) Frame = +2 Query: 2045 EINALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIAL 2224 EI + H N++ + ++ CG +++ E + GGSL + + + S+ Sbjct: 679 EILVMKDSSHPNIVNFIDSYLCGGELWVVMEFMEGGSLTDVV---TFNIMTEGQIASVCR 735 Query: 2225 EIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGI-AXXXXXXXXXXXXXGTYRWM 2401 E GL+++HS+GV+HRDIK +NIL +K+ DFG A GT WM Sbjct: 736 ETLLGLQHLHSKGVIHRDIKSDNILLSMEGNIKLTDFGFCATINEAQNKRTTMVGTPYWM 795 Query: 2402 APEMIKRKPYNRKVDVYSFGLLLWEMVTGRIPFENLSPVQVAYAVATDKLKPMDPQDYCP 2581 APE++ RK Y RKVD++S G++ EM+ G P+ SP++ + +AT+ + + Sbjct: 796 APEVVTRKEYGRKVDIWSLGIMAIEMIEGEPPYLTESPLRALWLIATNGTPQIKDEGNMS 855 Query: 2582 AAVRPLIEQCCALQPEKRPDFWQLVK 2659 R + + P+KR L++ Sbjct: 856 PVFRDFLYFALKVDPDKRASAHDLLR 881
>Q5BBL3:STE20_EMENI Serine/threonine-protein kinase ste20 - Emericella nidulans| (Aspergillus nidulans) Length = 848 Score = 112 bits (281), Expect = 7e-24 Identities = 64/207 (30%), Positives = 105/207 (50%), Gaps = 2/207 (0%) Frame = +2 Query: 2045 EINALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYL-HNPEHRPLPLERTISIA 2221 EI + HKN++ + ++ G +++ E + GGSL + N P + ++ Sbjct: 612 EILVMKDSKHKNIVNFLDSYLHGLDLWVVMEYMEGGSLTDVVTFNIMSEP----QIAAVC 667 Query: 2222 LEIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGI-AXXXXXXXXXXXXXGTYRW 2398 E GL+++HS+GV+HRDIK +NIL + +K+ DFG A GT W Sbjct: 668 RETLNGLQHLHSKGVIHRDIKSDNILLSLDGNIKLTDFGFCAQINDSQNKRNTMVGTPYW 727 Query: 2399 MAPEMIKRKPYNRKVDVYSFGLLLWEMVTGRIPFENLSPVQVAYAVATDKLKPMDPQDYC 2578 MAPE++ RK Y RKVD++S G++ EM+ G P+ SP++ Y +AT+ + + Sbjct: 728 MAPEVVTRKEYGRKVDIWSLGIMAIEMIEGEPPYLTESPLRALYLIATNGTPKIKDEHNL 787 Query: 2579 PAAVRPLIEQCCALQPEKRPDFWQLVK 2659 + + + PEKR L+K Sbjct: 788 SPVFKDFLHFALRVDPEKRASAHDLLK 814
>Q6FN53:STE20_CANGA Serine/threonine-protein kinase STE20 - Candida glabrata (Yeast)| (Torulopsis glabrata) Length = 915 Score = 112 bits (281), Expect = 7e-24 Identities = 66/227 (29%), Positives = 112/227 (49%), Gaps = 6/227 (2%) Frame = +2 Query: 1994 EDPGGIMAAKLDKQYN-----TEINALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSL 2158 ED I L+KQ EI + H N++ + ++ +I+ E + GGSL Sbjct: 643 EDSVAIKQMNLEKQPKKELILNEILVMRESKHSNIVNFIDSYLAKGDLWIVMEYMEGGSL 702 Query: 2159 RSYLHNPEHRPLPLERTISIALEIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFG 2338 + H L + ++ E +GL+++HS+GV+HRDIK +NIL +K+ DFG Sbjct: 703 TDVV---THCLLSEGQIGAVCRETLKGLQFLHSKGVLHRDIKSDNILLSLKGNIKLTDFG 759 Query: 2339 I-AXXXXXXXXXXXXXGTYRWMAPEMIKRKPYNRKVDVYSFGLLLWEMVTGRIPFENLSP 2515 A GT WMAPE++ RK Y KVD++S G+++ EM+ G P+ N +P Sbjct: 760 FCAQINENNLKRTTMVGTPYWMAPEVVSRKEYGPKVDIWSLGIMIIEMIEGEPPYLNETP 819 Query: 2516 VQVAYAVATDKLKPMDPQDYCPAAVRPLIEQCCALQPEKRPDFWQLV 2656 ++ Y +AT+ + + + ++ C + P +R +L+ Sbjct: 820 LRALYLIATNGTPKLKEPEALSDTLTKFLDWCLKVDPSERATATELL 866
>P25020:SRC_RSVH1 Tyrosine-protein kinase transforming protein Src - Rous sarcoma virus| (strain H-19) Length = 526 Score = 112 bits (281), Expect = 7e-24 Identities = 85/324 (26%), Positives = 146/324 (45%), Gaps = 4/324 (1%) Frame = +2 Query: 1685 CDMAASPDWCSTPVVFGEHSSQKDSSWTRRYFDNVGRRRVSAVENVRSRTVSMAQAVQST 1864 C + + + ++ FG S Q+ ++ ++ D + R + + +T +A+ Sbjct: 205 CKLYSGGFYITSRTQFG--SLQQLVAYYSKHADGLCHRLTNVCPTSKPQTQGLAKDA--- 259 Query: 1865 VDWKLDKAKLLVGHSFASGAHSRLYRGLYDDKP-VAIKFIRRPHEDPGGIMAAKLDKQYN 2041 W++ + L + G ++ G ++ VAIK ++ P + Sbjct: 260 --WEIPRESLRLEAKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQ-------- 309 Query: 2042 TEINALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIA 2221 E + L H+ +++L A P+Y +I E + GSL +L + L L + + +A Sbjct: 310 -EAQVMKKLRHEKLVQLYAVVSEEPIYIVI-EYMSKGSLLDFLKGEMGKYLRLPQLVDMA 367 Query: 2222 LEIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIAXXXXXXXXXXXXXGTY--R 2395 +IA G+ YV VHRD++ NIL EN K+ADFG+A + + Sbjct: 368 AQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIK 427 Query: 2396 WMAPEMIKRKPYNRKVDVYSFGLLLWEMVT-GRIPFENLSPVQVAYAVATDKLKPMDPQD 2572 W APE + K DV+SFG+LL E+ T GR+P+ + +V V P P+ Sbjct: 428 WTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERAYRMPCPPE- 486 Query: 2573 YCPAAVRPLIEQCCALQPEKRPDF 2644 CP ++ L+ QC PE+RP F Sbjct: 487 -CPESLHDLMCQCWRKDPEERPTF 509
>P07948:LYN_HUMAN Tyrosine-protein kinase Lyn - Homo sapiens (Human)| Length = 512 Score = 112 bits (281), Expect = 7e-24 Identities = 75/270 (27%), Positives = 131/270 (48%), Gaps = 4/270 (1%) Frame = +2 Query: 1871 WKLDKAKLLVGHSFASGAHSRLYRGLYDDKP-VAIKFIRRPHEDPGGIMAAKLDKQYNTE 2047 W++ + + + +G ++ G Y++ VA+K ++ PG + + + E Sbjct: 240 WEIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLK-----PGTMSV----QAFLEE 290 Query: 2048 INALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIALE 2227 N + L H +++L A YIITE + GSL +L + E + L + I + + Sbjct: 291 ANLMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQ 350 Query: 2228 IARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIAXXXXXXXXXXXXXGTY--RWM 2401 IA G+ Y+ + +HRD++ N+L E+ KIADFG+A + +W Sbjct: 351 IAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWT 410 Query: 2402 APEMIKRKPYNRKVDVYSFGLLLWEMVT-GRIPFENLSPVQVAYAVATDKLKPMDPQDYC 2578 APE I + K DV+SFG+LL+E+VT G+IP+ + V A++ P + C Sbjct: 411 APEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPR--VENC 468 Query: 2579 PAAVRPLIEQCCALQPEKRPDFWQLVKTLE 2668 P + +++ C + E+RP F L L+ Sbjct: 469 PDELYDIMKMCWKEKAEERPTFDYLQSVLD 498
>Q61UC4:KRAF1_CAEBR Raf homolog serine/threonine-protein kinase - Caenorhabditis briggsae| Length = 811 Score = 112 bits (281), Expect = 7e-24 Identities = 88/313 (28%), Positives = 146/313 (46%), Gaps = 13/313 (4%) Frame = +2 Query: 1775 YFDNVGRRRVSAVENVRSRTVSMAQAVQSTVDWKLDKAKLLVGHSFASGAHSRLYRGLYD 1954 +F N R +E R R Q DW++ + ++ + SG+ +YRG + Sbjct: 444 FFRNRSRSPGERIEAQRPRPPQKPQHE----DWEILPNEFVIHYKVGSGSFGTVYRGEFF 499 Query: 1955 DKPVAIKFIRRPHEDPGGIMAAKLDKQYNTEINALSHLYHKNVIKLVATHKCGPVYYIIT 2134 VAIK + P + A K E+ L H NV+ + + P IIT Sbjct: 500 GT-VAIKKLNVVDPTPSQMAAFK------NEVAVLKKTRHLNVLLFMGWVR-EPEIAIIT 551 Query: 2135 ELLPGGSLRSYLHNPEHR-PLPLERTISIALEIARGLEYVHSQGVVHRDIKPENI-LFDE 2308 + G SL ++H E R + I I +++ G+ Y+HS+ ++HRD+K NI L D+ Sbjct: 552 QWCEGSSLYRHIHVQEPRVEFEMSAVIDILKQVSLGMNYLHSKNIIHRDLKTNNIFLMDD 611 Query: 2309 NFEVKIADFGIA-----XXXXXXXXXXXXXGTYRWMAPEMIKRK---PYNRKVDVYSFGL 2464 VKI DFG+A G+ WMAPE+I+ + PY + DVYSFG+ Sbjct: 612 MSTVKIGDFGLATVKTKWTVNGGQQQQQPTGSILWMAPEVIRMQDDNPYTPQSDVYSFGV 671 Query: 2465 LLWEMVTGRIPFENL-SPVQVAYAVATDKLKP--MDPQDYCPAAVRPLIEQCCALQPEKR 2635 ++E+++ +P+ N+ + Q+ + V LKP + P ++ L + C +R Sbjct: 672 CMYEILSSHLPYSNINNRDQILFMVGRGYLKPDRSKIRTDTPKSLMKLYDNCIMFDRNER 731 Query: 2636 PDFWQLVKTLEKI 2674 P F ++++ L I Sbjct: 732 PVFGEVLERLRDI 744
>P14238:FES_FELCA Proto-oncogene tyrosine-protein kinase Fes/Fps - Felis silvestris| catus (Cat) Length = 820 Score = 112 bits (281), Expect = 7e-24 Identities = 82/278 (29%), Positives = 132/278 (47%), Gaps = 9/278 (3%) Frame = +2 Query: 1871 WKLDKAKLLVGHSFASGAHSRLYRGLY--DDKPVAIKFIRR---PHEDPGGIMAAKLDKQ 2035 W L+ L++G G ++ G D+ VA+K R P + AK+ KQ Sbjct: 552 WVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDIKAKFLQEAKILKQ 611 Query: 2036 YNTEINALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTIS 2215 Y+ H N+++L+ YI+ EL+ GG ++L R L ++ + Sbjct: 612 YS----------HPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGAR-LRMKTLLQ 660 Query: 2216 IALEIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIA---XXXXXXXXXXXXXG 2386 + + A G+EY+ S+ +HRD+ N L E +KI+DFG++ Sbjct: 661 MVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGIYAASGGLRQV 720 Query: 2387 TYRWMAPEMIKRKPYNRKVDVYSFGLLLWEMVT-GRIPFENLSPVQVAYAVATDKLKPMD 2563 +W APE + Y+ + DV+SFG+LLWE + G P+ NLS Q V +K + Sbjct: 721 PVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFV--EKGGRLP 778 Query: 2564 PQDYCPAAVRPLIEQCCALQPEKRPDFWQLVKTLEKIQ 2677 + CP AV L+EQC A +P +RP F + + L+ I+ Sbjct: 779 CPELCPDAVFRLMEQCWAYEPGQRPSFSAIYQELQSIR 816
>O53510:PKNL_MYCTU Probable serine/threonine-protein kinase pknL - Mycobacterium| tuberculosis Length = 399 Score = 112 bits (280), Expect = 9e-24 Identities = 69/219 (31%), Positives = 117/219 (53%), Gaps = 4/219 (1%) Frame = +2 Query: 1886 AKLLVGHSFASGAHSRLYRGLYD--DKPVAIKFIRRPHEDPGGIMAAKLDKQYNTEINAL 2059 ++ LV ASG S +YRGL D+PVA+K + + + ++ E A+ Sbjct: 17 SRYLVQAKIASGGTSTVYRGLDVRLDRPVALKVMDSRYAGDEQFLT-----RFRLEARAV 71 Query: 2060 SHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIALEIARG 2239 + L ++ ++ + K G +++ EL+ GG+LR L E P+P +++ + G Sbjct: 72 ARLNNRALVAVYDQGKDGRHPFLVMELIEGGTLRELLI--ERGPMPPHAVVAVLRPVLGG 129 Query: 2240 LEYVHSQGVVHRDIKPENILFDENFEVKIADFGI--AXXXXXXXXXXXXXGTYRWMAPEM 2413 L H G+VHRD+KPENIL ++ +VK+ADFG+ A GT +++PE Sbjct: 130 LAAAHRAGLVHRDVKPENILISDDGDVKLADFGLVRAVAAASITSTGVILGTAAYLSPEQ 189 Query: 2414 IKRKPYNRKVDVYSFGLLLWEMVTGRIPFENLSPVQVAY 2530 ++ + + DVYS G+L++E++TG PF S + +AY Sbjct: 190 VRDGNADPRSDVYSVGVLVYELLTGHTPFTGDSALSIAY 228
>Q7TYY6:PKNL_MYCBO Probable serine/threonine-protein kinase pknL - Mycobacterium bovis| Length = 399 Score = 112 bits (280), Expect = 9e-24 Identities = 69/219 (31%), Positives = 117/219 (53%), Gaps = 4/219 (1%) Frame = +2 Query: 1886 AKLLVGHSFASGAHSRLYRGLYD--DKPVAIKFIRRPHEDPGGIMAAKLDKQYNTEINAL 2059 ++ LV ASG S +YRGL D+PVA+K + + + ++ E A+ Sbjct: 17 SRYLVQAKIASGGTSTVYRGLDVRLDRPVALKVMDARYAGDEQFLT-----RFRLEARAV 71 Query: 2060 SHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIALEIARG 2239 + L ++ ++ + K G +++ EL+ GG+LR L E P+P +++ + G Sbjct: 72 ARLNNRALVAVYDQGKDGRHPFLVMELIEGGTLRELLI--ERGPMPPHAVVAVLRPVLGG 129 Query: 2240 LEYVHSQGVVHRDIKPENILFDENFEVKIADFGI--AXXXXXXXXXXXXXGTYRWMAPEM 2413 L H G+VHRD+KPENIL ++ +VK+ADFG+ A GT +++PE Sbjct: 130 LAAAHRAGLVHRDVKPENILISDDGDVKLADFGLVRAVAAASITSTGVILGTAAYLSPEQ 189 Query: 2414 IKRKPYNRKVDVYSFGLLLWEMVTGRIPFENLSPVQVAY 2530 ++ + + DVYS G+L++E++TG PF S + +AY Sbjct: 190 VRDGNADPRSDVYSVGVLVYELLTGHTPFTGDSALSIAY 228
>Q9V3Q6:M3K7_DROME Mitogen-activated protein kinase kinase kinase 7 - Drosophila| melanogaster (Fruit fly) Length = 678 Score = 112 bits (280), Expect = 9e-24 Identities = 80/287 (27%), Positives = 130/287 (45%), Gaps = 6/287 (2%) Frame = +2 Query: 1832 TVSMAQAVQSTVDWKLDKAKLLVGHSFASGAHSRLYRGLYDDKPVAIKFIRRPHEDPGGI 2011 T S+ + VD+ + VGH G++ + + ++ DK VA+K Sbjct: 3 TASLDALQAAYVDFSEITLREKVGH----GSYGVVCKAVWRDKLVAVK----------EF 48 Query: 2012 MAAKLDKQYNTEINALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRP 2191 A+ K E+ LS + H N+I L Y+I E GGSL ++LH Sbjct: 49 FASAEQKDIEKEVKQLSRVKHPNIIALHGISSYQQATYLIMEFAEGGSLHNFLHGKVKPA 108 Query: 2192 LPLERTISIALEIARGLEYVHS---QGVVHRDIKPENILF-DENFEVKIADFGIAXXXXX 2359 L +S A + A GL Y+H+ + ++HRD+KP N+L ++ +KI DFG Sbjct: 109 YSLAHAMSWARQCAEGLAYLHAMTPKPLIHRDVKPLNLLLTNKGRNLKICDFGTV--ADK 166 Query: 2360 XXXXXXXXGTYRWMAPEMIKRKPYNRKVDVYSFGLLLWEMVTGRIPFENLSPVQVAYAVA 2539 G+ WMAPE+ + Y K D++S+ ++LWE+++ + PF+ + AY + Sbjct: 167 STMMTNNRGSAAWMAPEVFEGSKYTEKCDIFSWAIVLWEVLSRKQPFKG---IDNAYTIQ 223 Query: 2540 TDKLKPMDPQ--DYCPAAVRPLIEQCCALQPEKRPDFWQLVKTLEKI 2674 K P CP + L+ C PE RP +V + +I Sbjct: 224 WKIYKGERPPLLTTCPKRIEDLMTACWKTVPEDRPSMQYIVGVMHEI 270
>P53666:LIMK2_CHICK LIM domain kinase 2 - Gallus gallus (Chicken)| Length = 642 Score = 112 bits (280), Expect = 9e-24 Identities = 74/271 (27%), Positives = 121/271 (44%), Gaps = 33/271 (12%) Frame = +2 Query: 1979 IRRPHEDPGGIMAAK--------LDKQYNTEINALSHLYHKNVIKLVATHKCGPVYYIIT 2134 I+ H+ G +M K K + TE+ + L H NV+K + ++T Sbjct: 346 IKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLT 405 Query: 2135 ELLPGGSLRSYLHNPEHRPLPLERTISIALEIARGLEYVHSQGVVHRDIKPENILFDENF 2314 E + GG+L+ +L N + P P ++ +S A IA G+ Y+HS ++HRD+ N L + Sbjct: 406 EYIEGGTLKDFLRNAD--PFPWQQKVSFAKGIASGMAYLHSMCIIHRDLNSHNCLIKLDK 463 Query: 2315 EVKIADFGIA---------------------XXXXXXXXXXXXXGTYRWMAPEMIKRKPY 2431 V +ADFG++ G WMAPEM+ + Y Sbjct: 464 TVVVADFGLSRLIVEERKKPTLEKPSAKKRTLRKSDRKKRYTVVGNPYWMAPEMLNGQSY 523 Query: 2432 NRKVDVYSFGLLLWEMVTGRIPFENLSPVQVAYAVAT----DKLKPMDPQDYCPAAVRPL 2599 + VD++SFG++L E++ + P + + + +K P D CP A PL Sbjct: 524 DETVDIFSFGIVLCEIIGQVYADPDCLPRTLDFGLNVKLFWEKFVPAD----CPPAFFPL 579 Query: 2600 IEQCCALQPEKRPDFWQLVKTLEKIQSVMSQ 2692 CC L+PE RP F +L + E + + + Sbjct: 580 AAICCRLEPESRPPFSKLEDSFEALSLYLGE 610
>Q03364:FGFR2_XENLA Fibroblast growth factor receptor 2 precursor - Xenopus laevis| (African clawed frog) Length = 813 Score = 112 bits (280), Expect = 9e-24 Identities = 75/232 (32%), Positives = 114/232 (49%), Gaps = 20/232 (8%) Frame = +2 Query: 2072 HKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERT-------------- 2209 HKN+I L+ G Y+I E G+LR YL RPL +E + Sbjct: 534 HKNIINLLGACTQGGTLYVIVEYAAKGNLRQYLR--ARRPLEMEYSFDVTRVPDEQMTFK 591 Query: 2210 --ISIALEIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIAXXXXXXXXXXXXX 2383 +S +IARG+EY+ SQ +HRD+ N+L EN +KIADFG+A Sbjct: 592 DLVSCTYQIARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDVNNIDYYKKTS 651 Query: 2384 G---TYRWMAPEMIKRKPYNRKVDVYSFGLLLWEMVT-GRIPFENLSPVQVAYAVATDKL 2551 +WMAPE + + Y + DV+SFG+L+WE+ T G P+ + PV+ + + + Sbjct: 652 NGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGI-PVEELFKLLKEGH 710 Query: 2552 KPMDPQDYCPAAVRPLIEQCCALQPEKRPDFWQLVKTLEKIQSVMSQGGSLD 2707 + MD C + ++ C P RP F QLV+ L++I ++ + LD Sbjct: 711 R-MDKPANCTNELYMMMRDCWHAIPSHRPTFKQLVEDLDRILTLTTNEEYLD 761
>Q23023:UNC51_CAEEL Serine/threonine-protein kinase unc-51 - Caenorhabditis elegans| Length = 856 Score = 112 bits (279), Expect = 1e-23 Identities = 82/251 (32%), Positives = 128/251 (50%), Gaps = 15/251 (5%) Frame = +2 Query: 1895 LVGHSFASGAHSRLYRGLYDDK---PVAIKFIRRPHEDPGGIMAAKLDKQYNTEINALSH 2065 L+GH GA + +YRG Y D+ PVAIK I + + + K K + LS Sbjct: 14 LLGH----GAFAIVYRGRYVDRTDVPVAIKAIAKKNISKSKNLLTKEIKI----LKELSS 65 Query: 2066 LYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTIS-IALEIARGL 2242 L H+N++ L+ + Y++ E GG L YL + + E TI ++IA L Sbjct: 66 LKHENLVGLLKCTETPTHVYLVMEFCNGGDLADYL---QQKTTLNEDTIQHFVVQIAHAL 122 Query: 2243 EYVHSQGVVHRDIKPENILFDENFE----------VKIADFGIAXXXXXXXXXXXXXGTY 2392 E ++ +G+VHRD+KP+NIL N +K+ADFG A G+ Sbjct: 123 EAINKKGIVHRDLKPQNILLCNNSRTQNPHFTDIVIKLADFGFARFLNDGVMAATLCGSP 182 Query: 2393 RWMAPEMIKRKPYNRKVDVYSFGLLLWEMVTGRIPFENLSPVQV-AYAVATDKLKPMDPQ 2569 +MAPE+I Y+ K D++S G +L++ +TG+ PF +P Q+ AY T +L+P P Sbjct: 183 MYMAPEVIMSMQYDAKADLWSIGTILFQCLTGKAPFVAQTPPQLKAYYEKTRELRPNIP- 241 Query: 2570 DYCPAAVRPLI 2602 ++C +R L+ Sbjct: 242 EWCSPNLRDLL 252
>Q97IC2:PKN2_CLOAB Probable serine/threonine protein kinase CA_C1728 - Clostridium| acetobutylicum Length = 657 Score = 112 bits (279), Expect = 1e-23 Identities = 60/204 (29%), Positives = 109/204 (53%), Gaps = 3/204 (1%) Frame = +2 Query: 2033 QYNTEINALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTI 2212 ++ E +A + + + N++ + G V YI+ E + G +L+ + E+ + + I Sbjct: 54 KFKREASAAARIANANIVNIYDVGADGNVNYIVMEYVAGKTLKKLIK--ENGKIEFNKII 111 Query: 2213 SIALEIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGI--AXXXXXXXXXXXXXG 2386 A +IA+ L + H G+VHRDIKP NI+ ++ +K+ DFGI A G Sbjct: 112 DYATQIAKALNFAHKNGIVHRDIKPHNIMVTDDDIIKVTDFGIAKASNESTITTTNKVVG 171 Query: 2387 TYRWMAPEMIKRKPYNRKVDVYSFGLLLWEMVTGRIPFENLSPVQVAYAVATD-KLKPMD 2563 + +++PE + P + + D+YSFG++L+EM TG++P++ +PV +A D + P + Sbjct: 172 SAHYLSPEQAQGIPVDCRTDIYSFGIVLYEMATGKVPYDADTPVSIALKHIQDAAVPPNE 231 Query: 2564 PQDYCPAAVRPLIEQCCALQPEKR 2635 P A+ +I +C +PE R Sbjct: 232 LNKDIPIALNKMILRCIEKKPENR 255
>P32593:MOS_MSVMT Serine/threonine-protein kinase-transforming protein mos - Moloney| murine sarcoma virus (strain ts110) Length = 354 Score = 112 bits (279), Expect = 1e-23 Identities = 81/297 (27%), Positives = 140/297 (47%), Gaps = 22/297 (7%) Frame = +2 Query: 1862 TVDWKLDKAKLLVGHSFASGAHSRLYRGLYDDKPVAIKFIRRPHEDPGGIMAAKLDKQYN 2041 ++DW+ ++ + H SG +Y+ Y PVAIK + + ED + A++ + + Sbjct: 68 SIDWE----QVCLMHRLGSGGFGSVYKATYHGVPVAIKQVNKCTED---LRASQ--RSFW 118 Query: 2042 TEINALSHLYHKNVIKLVATHKCGP-----VYYIITELLPGGSLRSYLHNPEHRPLPLE- 2203 E+N ++ L H N++++VA P + II E +L +++ P PL Sbjct: 119 AELN-IAGLRHDNIVRVVAASTRTPEDSNSLGTIIMEFGGNVTLHQVIYDATRSPEPLSC 177 Query: 2204 -------RTISIALEIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFG----IAXX 2350 + + +L++ GL ++HSQ ++H D+KP NIL E KI+DFG + Sbjct: 178 RKQLSLGKCLKYSLDVVNGLLFLHSQSILHLDLKPANILISEQDVCKISDFGCSQKLQVL 237 Query: 2351 XXXXXXXXXXXGTYRWMAPEMIKRKPYNRKVDVYSFGLLLWEMVTGRIPFENLSPVQVAY 2530 GTY APE++K + K D+YSFG+ LW+M T +P+ P V Y Sbjct: 238 RGRQASPPHIGGTYTHQAPEILKGEIATPKADIYSFGITLWQMTTREVPYSG-EPQYVQY 296 Query: 2531 AVATDKLKP-----MDPQDYCPAAVRPLIEQCCALQPEKRPDFWQLVKTLEKIQSVM 2686 AV L+P + A++ +I+ C + +RP L + L+ + + Sbjct: 297 AVVAYNLRPSLAGAVFTASLTGKALQNIIQSCWEARGLQRPSAELLQRDLKAFRGTL 353
>P00538:MOS_MSVMO Serine/threonine-protein kinase-transforming protein mos - Moloney| murine sarcoma virus (MoMLV) Length = 374 Score = 112 bits (279), Expect = 1e-23 Identities = 81/297 (27%), Positives = 140/297 (47%), Gaps = 22/297 (7%) Frame = +2 Query: 1862 TVDWKLDKAKLLVGHSFASGAHSRLYRGLYDDKPVAIKFIRRPHEDPGGIMAAKLDKQYN 2041 ++DW+ ++ + H SG +Y+ Y PVAIK + + ED + A++ + + Sbjct: 88 SIDWE----QVCLMHRLGSGGFGSVYKATYHGVPVAIKQVNKCTED---LRASQ--RSFW 138 Query: 2042 TEINALSHLYHKNVIKLVATHKCGP-----VYYIITELLPGGSLRSYLHNPEHRPLPLE- 2203 E+N ++ L H N++++VA P + II E +L +++ P PL Sbjct: 139 AELN-IAGLRHDNIVRVVAASTRTPEDSNSLGTIIMEFGGNVTLHQVIYDATRSPEPLSC 197 Query: 2204 -------RTISIALEIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFG----IAXX 2350 + + +L++ GL ++HSQ ++H D+KP NIL E KI+DFG + Sbjct: 198 RKQLSLGKCLKYSLDVVNGLLFLHSQSILHLDLKPANILISEQDVCKISDFGCSQKLQDL 257 Query: 2351 XXXXXXXXXXXGTYRWMAPEMIKRKPYNRKVDVYSFGLLLWEMVTGRIPFENLSPVQVAY 2530 GTY APE++K + K D+YSFG+ LW+M T +P+ P V Y Sbjct: 258 RGRQASPPHIGGTYTHQAPEILKGEIATPKADIYSFGITLWQMTTREVPYSG-EPQYVQY 316 Query: 2531 AVATDKLKP-----MDPQDYCPAAVRPLIEQCCALQPEKRPDFWQLVKTLEKIQSVM 2686 AV L+P + A++ +I+ C + +RP L + L+ + + Sbjct: 317 AVVAYNLRPSLAGAVFTASLTGKALQNIIQSCWEARGLQRPSAELLQRDLKAFRGTL 373
>Q93105:INSR_AEDAE Insulin-like receptor precursor - Aedes aegypti (Yellowfever| mosquito) Length = 1390 Score = 112 bits (279), Expect = 1e-23 Identities = 78/289 (26%), Positives = 138/289 (47%), Gaps = 23/289 (7%) Frame = +2 Query: 1868 DWKLDKAKLLVGHSFASGAHSRLYRGLYD-------DKPVAIKFIRRP---HEDPGGIMA 2017 DW++++ ++ G+ +Y+G+ ++P AIK + E ++ Sbjct: 1017 DWEVERNHIIQLEELGQGSFGMVYKGILTQLRGEKCNQPCAIKTVNESATAREKDSFLLE 1076 Query: 2018 AKLDKQYNTEINALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYL--HNPEH-- 2185 A + KQ+NT +V++L+ G +I EL+ G L+SYL H P++ Sbjct: 1077 ASVMKQFNTH----------HVVRLLGVVSQGDPTLVIMELMANGDLKSYLRRHRPDYEM 1126 Query: 2186 -----RPLPLERTISIALEIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIAXX 2350 +P L + I +A+EIA G+ + ++ VHRD+ N + ++ VKI DFG+ Sbjct: 1127 RRSIRQPPTLRQIIQMAIEIADGIGVLSAKKFVHRDLAARNCMVADDMTVKIGDFGMTRD 1186 Query: 2351 XXXXXXXXXXXGTY---RWMAPEMIKRKPYNRKVDVYSFGLLLWEMVT-GRIPFENLSPV 2518 + RWMAPE +K ++ DV+S+G++LWEM T P++ L+ Sbjct: 1187 IYETDYYRKGTKGFLPVRWMAPESLKDGIFSSSSDVFSYGVVLWEMATLASQPYQGLTND 1246 Query: 2519 QVAYAVATDKLKPMDPQDYCPAAVRPLIEQCCALQPEKRPDFWQLVKTL 2665 QV V + M+ + CP + L+ +C +P RP F +++ L Sbjct: 1247 QVLRYVIDGGV--MERPENCPDNLYNLMRRCWQHRPTARPTFMEIISEL 1293
>P07332:FES_HUMAN Proto-oncogene tyrosine-protein kinase Fes/Fps - Homo sapiens (Human)| Length = 822 Score = 112 bits (279), Expect = 1e-23 Identities = 79/275 (28%), Positives = 129/275 (46%), Gaps = 6/275 (2%) Frame = +2 Query: 1871 WKLDKAKLLVGHSFASGAHSRLYRGLY--DDKPVAIKFIRRPHEDPGGIMAAKLDKQYNT 2044 W L+ L++G G ++ G D+ VA+K R + L ++ Sbjct: 554 WVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRET-------LPPDLKAKFLQ 606 Query: 2045 EINALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIAL 2224 E L H N+++L+ YI+ EL+ GG ++L R L ++ + + Sbjct: 607 EARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGAR-LRVKTLLQMVG 665 Query: 2225 EIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIA---XXXXXXXXXXXXXGTYR 2395 + A G+EY+ S+ +HRD+ N L E +KI+DFG++ + Sbjct: 666 DAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVK 725 Query: 2396 WMAPEMIKRKPYNRKVDVYSFGLLLWEMVT-GRIPFENLSPVQVAYAVATDKLKPMDPQD 2572 W APE + Y+ + DV+SFG+LLWE + G P+ NLS Q V +K + + Sbjct: 726 WTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFV--EKGGRLPCPE 783 Query: 2573 YCPAAVRPLIEQCCALQPEKRPDFWQLVKTLEKIQ 2677 CP AV L+EQC A +P +RP F + + L+ I+ Sbjct: 784 LCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSIR 818
>P00543:FES_FSVST Tyrosine-protein kinase transforming protein Fes - Feline sarcoma| virus (strain Snyder-Theilen) Length = 477 Score = 112 bits (279), Expect = 1e-23 Identities = 82/278 (29%), Positives = 131/278 (47%), Gaps = 9/278 (3%) Frame = +2 Query: 1871 WKLDKAKLLVGHSFASGAHSRLYRGLY--DDKPVAIKFIRR---PHEDPGGIMAAKLDKQ 2035 W L+ L++G G ++ G D+ VA+K R P + AK+ KQ Sbjct: 209 WVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDIKAKFLQEAKILKQ 268 Query: 2036 YNTEINALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTIS 2215 Y+ H N+++L+ YI+ EL+ GG ++L R L ++ + Sbjct: 269 YS----------HPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGAR-LRMKTLLQ 317 Query: 2216 IALEIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIA---XXXXXXXXXXXXXG 2386 + + A G+EY+ S+ +HRD+ N L E +KI+DFG++ Sbjct: 318 MVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRLV 377 Query: 2387 TYRWMAPEMIKRKPYNRKVDVYSFGLLLWEMVT-GRIPFENLSPVQVAYAVATDKLKPMD 2563 +W APE + Y+ + DV+SFG+LLWE + G P+ NLS Q V +K + Sbjct: 378 PVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFV--EKGGRLP 435 Query: 2564 PQDYCPAAVRPLIEQCCALQPEKRPDFWQLVKTLEKIQ 2677 + CP AV L+EQC A +P +RP F + L+ I+ Sbjct: 436 CPELCPDAVFRLMEQCWAYEPGQRPSFSAFYQELQSIR 473
>Q15569:TESK1_HUMAN Dual specificity testis-specific protein kinase 1 - Homo sapiens| (Human) Length = 626 Score = 111 bits (278), Expect = 2e-23 Identities = 78/264 (29%), Positives = 130/264 (49%), Gaps = 15/264 (5%) Frame = +2 Query: 1991 HEDPGGIMAAKLDK----QYNT--EINALSHLYHKNVIKLVATHKCGPVYYIITELLPGG 2152 H G +M K++K + NT E+ ++ L H N+++ + + +TE + GG Sbjct: 76 HRQSGQVMVLKMNKLPSNRGNTLREVQLMNRLRHPNILRFMGVCVHQGQLHALTEYMNGG 135 Query: 2153 SLRSYLHNPEHRPLPLERTISIALEIARGLEYVHSQGVVHRDIKPENILF---DENFEVK 2323 +L L +PE PL + +AL+IARGL Y+HS+GV HRD+ +N L D F Sbjct: 136 TLEQLLSSPE--PLSWPVRLHLALDIARGLRYLHSKGVFHRDLTSKNCLVRREDRGFTAV 193 Query: 2324 IADFGIA-----XXXXXXXXXXXXXGTYRWMAPEMIKRKPYNRKVDVYSFGLLLWEMVTG 2488 + DFG+A G+ WMAPE+++ + Y+ K DV++FG++L E++ Sbjct: 194 VGDFGLAEKIPVYREGARKEPLAVVGSPYWMAPEVLRGELYDEKADVFAFGIVLCELI-A 252 Query: 2489 RIPFE-NLSPVQVAYAVATDKLKPMDPQDYCPAAVRPLIEQCCALQPEKRPDFWQLVKTL 2665 R+P + + P + + + + D CP L CC L+P R F ++ + L Sbjct: 253 RVPADPDYLPRTEDFGLDVPAFRTLVGDD-CPLPFLLLAIHCCNLEPSTRAPFTEITQHL 311 Query: 2666 EKIQSVMSQGGSLDTLRSSGHKKG 2737 E I + + L T + H +G Sbjct: 312 EWILEQLPEPAPL-TRTALTHNQG 334
>Q4WHP3:STE20_ASPFU Serine/threonine-protein kinase ste20 - Aspergillus fumigatus| (Sartorya fumigata) Length = 815 Score = 111 bits (278), Expect = 2e-23 Identities = 61/198 (30%), Positives = 101/198 (51%), Gaps = 1/198 (0%) Frame = +2 Query: 2045 EINALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIAL 2224 EI + HKN++ + ++ G +++ E + GGSL + + + ++ Sbjct: 579 EILVMKDSKHKNIVNFLDSYLHGLDLWVVMEYMEGGSLTDVV---TFNIMTEGQIAAVCR 635 Query: 2225 EIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGI-AXXXXXXXXXXXXXGTYRWM 2401 E GL+++HS+GV+HRDIK +NIL + +K+ DFG A GT WM Sbjct: 636 ETLNGLQHLHSKGVIHRDIKSDNILLSLDGNIKLTDFGFCAQINDSQNKRNTMVGTPYWM 695 Query: 2402 APEMIKRKPYNRKVDVYSFGLLLWEMVTGRIPFENLSPVQVAYAVATDKLKPMDPQDYCP 2581 APE++ RK Y RKVD++S G++ EM+ G P+ SP++ Y +AT+ + + Sbjct: 696 APEVVTRKEYGRKVDIWSLGIMAIEMIEGEPPYLTESPLRALYLIATNGTPTIKDEHNLS 755 Query: 2582 AAVRPLIEQCCALQPEKR 2635 R + + PEKR Sbjct: 756 PVFRDFLHLALKVDPEKR 773
>Q62073:M3K7_MOUSE Mitogen-activated protein kinase kinase kinase 7 - Mus musculus| (Mouse) Length = 579 Score = 111 bits (278), Expect = 2e-23 Identities = 83/276 (30%), Positives = 134/276 (48%), Gaps = 9/276 (3%) Frame = +2 Query: 1865 VDWKLDKAKLLVGHSFASGAHSRLYRGLYDDKPVAIKFIRRPHEDPGGIMAAKLDKQYNT 2044 +D+K + + +VG GA + + + K VAIK I E K + Sbjct: 31 IDYKEIEVEEVVGR----GAFGVVCKAKWRAKDVAIKQIESESER----------KAFIV 76 Query: 2045 EINALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPL---ERTIS 2215 E+ LS + H N++KL C ++ E GGSL + LH E PLP +S Sbjct: 77 ELRQLSRVNHPNIVKLYGA--CLNPVCLVMEYAEGGSLYNVLHGAE--PLPYYTAAHAMS 132 Query: 2216 IALEIARGLEYVHS---QGVVHRDIKPENILFDENFEV-KIADFGIAXXXXXXXXXXXXX 2383 L+ ++G+ Y+HS + ++HRD+KP N+L V KI DFG A Sbjct: 133 WCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNK-- 190 Query: 2384 GTYRWMAPEMIKRKPYNRKVDVYSFGLLLWEMVTGRIPFENLS--PVQVAYAVATDKLKP 2557 G+ WMAPE+ + Y+ K DV+S+G++LWE++T R PF+ + ++ +AV P Sbjct: 191 GSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPP 250 Query: 2558 MDPQDYCPAAVRPLIEQCCALQPEKRPDFWQLVKTL 2665 + P + L+ +C + P +RP ++VK + Sbjct: 251 LIKN--LPKPIESLMTRCWSKDPSQRPSMEEIVKIM 284
>O43318:M3K7_HUMAN Mitogen-activated protein kinase kinase kinase 7 - Homo sapiens| (Human) Length = 606 Score = 111 bits (278), Expect = 2e-23 Identities = 83/276 (30%), Positives = 134/276 (48%), Gaps = 9/276 (3%) Frame = +2 Query: 1865 VDWKLDKAKLLVGHSFASGAHSRLYRGLYDDKPVAIKFIRRPHEDPGGIMAAKLDKQYNT 2044 +D+K + + +VG GA + + + K VAIK I E K + Sbjct: 31 IDYKEIEVEEVVGR----GAFGVVCKAKWRAKDVAIKQIESESER----------KAFIV 76 Query: 2045 EINALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPL---ERTIS 2215 E+ LS + H N++KL C ++ E GGSL + LH E PLP +S Sbjct: 77 ELRQLSRVNHPNIVKLYGA--CLNPVCLVMEYAEGGSLYNVLHGAE--PLPYYTAAHAMS 132 Query: 2216 IALEIARGLEYVHS---QGVVHRDIKPENILFDENFEV-KIADFGIAXXXXXXXXXXXXX 2383 L+ ++G+ Y+HS + ++HRD+KP N+L V KI DFG A Sbjct: 133 WCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNK-- 190 Query: 2384 GTYRWMAPEMIKRKPYNRKVDVYSFGLLLWEMVTGRIPFENLS--PVQVAYAVATDKLKP 2557 G+ WMAPE+ + Y+ K DV+S+G++LWE++T R PF+ + ++ +AV P Sbjct: 191 GSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPP 250 Query: 2558 MDPQDYCPAAVRPLIEQCCALQPEKRPDFWQLVKTL 2665 + P + L+ +C + P +RP ++VK + Sbjct: 251 LIKN--LPKPIESLMTRCWSKDPSQRPSMEEIVKIM 284
>P53670:LIMK2_RAT LIM domain kinase 2 - Rattus norvegicus (Rat)| Length = 638 Score = 111 bits (278), Expect = 2e-23 Identities = 75/271 (27%), Positives = 120/271 (44%), Gaps = 33/271 (12%) Frame = +2 Query: 1979 IRRPHEDPGGIMAAK--------LDKQYNTEINALSHLYHKNVIKLVATHKCGPVYYIIT 2134 I+ H+ G +M K K + TE+ + L H NV+K + ++T Sbjct: 346 IKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLT 405 Query: 2135 ELLPGGSLRSYLHNPEHRPLPLERTISIALEIARGLEYVHSQGVVHRDIKPENILFDENF 2314 E + GG+L+ +L N + P P ++ + A IA G+ Y+HS ++HRD+ N L + Sbjct: 406 EYIEGGTLKDFLRNVD--PFPWQQKVRFAKGIASGMAYLHSMCIIHRDLNSHNCLIKLDK 463 Query: 2315 EVKIADFGIA---------------------XXXXXXXXXXXXXGTYRWMAPEMIKRKPY 2431 V +ADFG++ G WMAPEM+ K Y Sbjct: 464 TVVVADFGLSRLIVEERKRPPVEKAATKKRTLRKSDRKKRYTVVGNPYWMAPEMLNGKSY 523 Query: 2432 NRKVDVYSFGLLLWEMVTGRIPFENLSPVQVAYAVAT----DKLKPMDPQDYCPAAVRPL 2599 + VDV+SFG++L E++ + P + + + +K P D CP A PL Sbjct: 524 DETVDVFSFGIVLCEIIGQVYADPDCLPRTLDFGLNVKLFWEKFVPTD----CPPAFFPL 579 Query: 2600 IEQCCALQPEKRPDFWQLVKTLEKIQSVMSQ 2692 CC L+PE RP F +L + E + + + Sbjct: 580 AAICCKLEPESRPAFSKLEDSFEALSLFLGE 610
>Q92212:STE20_CANAL Serine/threonine-protein kinase CST20 - Candida albicans (Yeast)| Length = 1228 Score = 111 bits (277), Expect = 2e-23 Identities = 63/205 (30%), Positives = 106/205 (51%), Gaps = 1/205 (0%) Frame = +2 Query: 2045 EINALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIAL 2224 EI + H N++ + ++ ++I E + GGSL + H + + + Sbjct: 997 EILVMKGSSHPNIVNFIDSYLLKGDLWVIMEYMEGGSLTDIV---THSVMTEGQIGVVCR 1053 Query: 2225 EIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGI-AXXXXXXXXXXXXXGTYRWM 2401 E +GL+++HS+GV+HRDIK +NIL + + +KI DFG A GT WM Sbjct: 1054 ETLKGLKFLHSKGVIHRDIKSDNILLNMDGNIKITDFGFCAQINEINSKRITMVGTPYWM 1113 Query: 2402 APEMIKRKPYNRKVDVYSFGLLLWEMVTGRIPFENLSPVQVAYAVATDKLKPMDPQDYCP 2581 APE++ RK Y KVDV+S G+++ EM+ G P+ N +P++ Y +AT+ + + Sbjct: 1114 APEIVSRKEYGPKVDVWSLGIMIIEMLEGEPPYLNETPLRALYLIATNGTPKLKDPESLS 1173 Query: 2582 AAVRPLIEQCCALQPEKRPDFWQLV 2656 +R + C + KR D +L+ Sbjct: 1174 YDIRKFLAWCLQVDFNKRADADELL 1198
>Q03142:FGFR4_MOUSE Fibroblast growth factor receptor 4 precursor - Mus musculus (Mouse)| Length = 799 Score = 111 bits (277), Expect = 2e-23 Identities = 82/307 (26%), Positives = 142/307 (46%), Gaps = 33/307 (10%) Frame = +2 Query: 1871 WKLDKAKLLVGHSFASGAHSRLYR----GLYDDKPVAIKFIRRPHEDPGGIMAAKLDKQY 2038 W+ + +L++G G ++ R G+ +P D +A K+ K Sbjct: 457 WEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPSRP-----------DQTSTVAVKMLKDN 505 Query: 2039 NTEINALSHLYHKNVIKLVATHK--------C---GPVYYIITELLPGGSLRSYLH---- 2173 ++ + + V+KL+ HK C GP+Y +I E G+LR +L Sbjct: 506 ASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLY-VIVECAAKGNLREFLRARRP 564 Query: 2174 ----------NPEHRPLPLERTISIALEIARGLEYVHSQGVVHRDIKPENILFDENFEVK 2323 PL +S A ++ARG++Y+ S+ +HRD+ N+L E+ +K Sbjct: 565 PGPDLSPDGPRSSEGPLSFPALVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDDVMK 624 Query: 2324 IADFGIAXXXXXXXXXXXXXG---TYRWMAPEMIKRKPYNRKVDVYSFGLLLWEMVT-GR 2491 IADFG+A +WMAPE + + Y + DV+SF +LLWE+ T G Sbjct: 625 IADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFEILLWEIFTLGG 684 Query: 2492 IPFENLSPVQVAYAVATDKLKPMDPQDYCPAAVRPLIEQCCALQPEKRPDFWQLVKTLEK 2671 P+ + PV+ +++ + + M+ CP+ + L+ +C P +RP F QLV+ L+K Sbjct: 685 SPYPGI-PVEELFSLLREGHR-MERPPNCPSELYGLMRECWHAAPSQRPTFKQLVEALDK 742 Query: 2672 IQSVMSQ 2692 + +S+ Sbjct: 743 VLLAVSE 749
>Q61851:FGFR3_MOUSE Fibroblast growth factor receptor 3 precursor - Mus musculus (Mouse)| Length = 801 Score = 111 bits (277), Expect = 2e-23 Identities = 87/310 (28%), Positives = 145/310 (46%), Gaps = 31/310 (10%) Frame = +2 Query: 1871 WKLDKAKLLVGHSFASGAHSRLYR----GLYDD---KPVAIKFIRRPHEDPGGIMAAKLD 2029 W+L + +L +G G ++ G+ D KPV + ++ +D D Sbjct: 459 WELSRTRLTLGKPLGEGCFGQVVMAEAIGIDKDRTAKPVTVA-VKMLKDDA-------TD 510 Query: 2030 KQYNTEINALSHLY----HKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHN------- 2176 K + ++ + + HKN+I L+ G Y++ E G+LR +L Sbjct: 511 KDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGMD 570 Query: 2177 --------PEHRPLPLERTISIALEIARGLEYVHSQGVVHRDIKPENILFDENFEVKIAD 2332 PE + L + +S A ++ARG+EY+ SQ +HRD+ N+L E+ +KIAD Sbjct: 571 YSFDACRLPEEQ-LTCKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIAD 629 Query: 2333 FGIAXXXXXXXXXXXXXG---TYRWMAPEMIKRKPYNRKVDVYSFGLLLWEMVT--GRIP 2497 FG+A +WMAPE + + Y + DV+SFG+LLWE+ T G P Sbjct: 630 FGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTPGGPSP 689 Query: 2498 FENLSPVQVAYAVATDKLKPMDPQDYCPAAVRPLIEQCCALQPEKRPDFWQLVKTLEKIQ 2677 + + PV+ + + + + MD C + ++ +C P +RP F QLV+ L++I Sbjct: 690 YPGI-PVEELFKLLKEGHR-MDKPASCTHDLYMIMRECWHAVPSQRPTFKQLVEDLDRIL 747 Query: 2678 SVMSQGGSLD 2707 +V S LD Sbjct: 748 TVTSTDEYLD 757
>P07947:YES_HUMAN Proto-oncogene tyrosine-protein kinase Yes - Homo sapiens (Human)| Length = 543 Score = 110 bits (276), Expect = 3e-23 Identities = 83/300 (27%), Positives = 138/300 (46%), Gaps = 4/300 (1%) Frame = +2 Query: 1781 DNVGRRRVSAVENVRSRTVSMAQAVQSTVDWKLDKAKLLVGHSFASGAHSRLYRGLYDDK 1960 D + + + V+ +T +A+ W++ + L + G ++ G ++ Sbjct: 245 DGLCHKLTTVCPTVKPQTQGLAKDA-----WEIPRESLRLEVKLGQGCFGEVWMGTWNGT 299 Query: 1961 P-VAIKFIRRPHEDPGGIMAAKLDKQYNTEINALSHLYHKNVIKLVATHKCGPVYYIITE 2137 VAIK ++ PG +M + + E + L H ++ L A P+Y I+TE Sbjct: 300 TKVAIKTLK-----PGTMMP----EAFLQEAQIMKKLRHDKLVPLYAVVSEEPIY-IVTE 349 Query: 2138 LLPGGSLRSYLHNPEHRPLPLERTISIALEIARGLEYVHSQGVVHRDIKPENILFDENFE 2317 + GSL +L + + L L + + +A +IA G+ Y+ +HRD++ NIL EN Sbjct: 350 FMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLV 409 Query: 2318 VKIADFGIAXXXXXXXXXXXXXGTY--RWMAPEMIKRKPYNRKVDVYSFGLLLWEMVT-G 2488 KIADFG+A + +W APE + K DV+SFG+L E+VT G Sbjct: 410 CKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKG 469 Query: 2489 RIPFENLSPVQVAYAVATDKLKPMDPQDYCPAAVRPLIEQCCALQPEKRPDFWQLVKTLE 2668 R+P+ + +V V P PQ CP ++ L+ C P++RP F + LE Sbjct: 470 RVPYPGMVNREVLEQVERGYRMPC-PQG-CPESLHELMNLCWKKDPDERPTFEYIQSFLE 527
>P31693:SRC_RSVPA Tyrosine-protein kinase transforming protein Src - Rous sarcoma virus| (strain PA101T) Length = 523 Score = 110 bits (276), Expect = 3e-23 Identities = 82/305 (26%), Positives = 138/305 (45%), Gaps = 4/305 (1%) Frame = +2 Query: 1742 SSQKDSSWTRRYFDNVGRRRVSAVENVRSRTVSMAQAVQSTVDWKLDKAKLLVGHSFASG 1921 S Q+ ++ ++ D + R + + +T +A+ W++ + L + G Sbjct: 219 SLQQLVAYYSKHADGLCHRLTNVCPTSKPQTQGLAKDA-----WEIPRESLRLEVKLGQG 273 Query: 1922 AHSRLYRGLYDDKP-VAIKFIRRPHEDPGGIMAAKLDKQYNTEINALSHLYHKNVIKLVA 2098 ++ G ++ VAIK ++ P + E + L H+ +++L A Sbjct: 274 YFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQ---------EAQVMKKLRHEKLVQLYA 324 Query: 2099 THKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIALEIARGLEYVHSQGVVHRD 2278 P+Y +I E + GSL +L + L L + + +A +IA G+ YV VHRD Sbjct: 325 MVSEEPIYIVI-EYMSKGSLLDFLKGEMGKYLRLPQLVEMAAQIASGMAYVERMNYVHRD 383 Query: 2279 IKPENILFDENFEVKIADFGIAXXXXXXXXXXXXXGTY--RWMAPEMIKRKPYNRKVDVY 2452 ++ NIL EN K+ADFG+A + +W APE + K DV+ Sbjct: 384 LRAANILVGENLVCKVADFGLARLIEDNEYTARPGARFPVKWTAPEAALYGRFTIKSDVW 443 Query: 2453 SFGLLLWEMVT-GRIPFENLSPVQVAYAVATDKLKPMDPQDYCPAAVRPLIEQCCALQPE 2629 SFG+LL E+ T GR+P+ + +V V P P+ CP ++ L+ QC PE Sbjct: 444 SFGILLTELTTKGRVPYPGMVNGEVLDRVERGYRMPCPPE--CPESLHDLMCQCWRKDPE 501 Query: 2630 KRPDF 2644 +RP F Sbjct: 502 ERPTF 506
>Q2IBC0:MET_RHIFE Hepatocyte growth factor receptor precursor - Rhinolophus| ferrumequinum (Greater horseshoe bat) Length = 1381 Score = 110 bits (276), Expect = 3e-23 Identities = 104/389 (26%), Positives = 177/389 (45%), Gaps = 27/389 (6%) Frame = +2 Query: 1595 RASSQRFTSPPPKRVGSDKSVYGKSLGREQ---------CDMAASPDWCSTPVVFGEHSS 1747 R S R SP + V ++ Y + +Q C P +P++ G Sbjct: 982 RLVSARSISPTTEMVSNESVDYRATFPEDQFANSSQNGSCRQVQCPLMDLSPILPGG--- 1038 Query: 1748 QKDSSWTRRYFDNVGRRRVSAVENVRSRTVSMAQAVQSTVDWKLDKAKLLVGHS--FASG 1921 DS + N R +SA+ + QAVQ V + ++L+V + G Sbjct: 1039 --DSDISSPLLQNTVRIDLSALNP------ELVQAVQHVV---IGPSRLIVHFNEVIGRG 1087 Query: 1922 AHSRLYRGLY---DDKPV--AIKFIRRPHEDPGGIMAAKLDKQYNTEINALSHLYHKNVI 2086 +Y G DDK + A+K + R D G + Q+ TE + H NV+ Sbjct: 1088 HFGCVYHGTLLDNDDKKIHCAVKSLNRI-TDIGEV------SQFLTEGIIMKDFSHPNVL 1140 Query: 2087 KLVAT---HKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIALEIARGLEYVHS 2257 L+ + P+ ++ + G LR+++ N H P ++ I L++A+G++Y+ S Sbjct: 1141 SLLGICLRSEGSPL--VVLPYMKHGDLRNFIRNETHNPT-VKDLIGFGLQVAKGMKYLAS 1197 Query: 2258 QGVVHRDIKPENILFDENFEVKIADFGIAXXXXXXXXXXXXXGT-----YRWMAPEMIKR 2422 + VHRD+ N + DENF VK+ADFG+A T +WMA E ++ Sbjct: 1198 KKFVHRDLAARNCMLDENFTVKVADFGLARDVYDKEYYSVHNKTGAKLPVKWMALESLQT 1257 Query: 2423 KPYNRKVDVYSFGLLLWEMVT-GRIPFENLSPVQVAYAVATDK--LKPMDPQDYCPAAVR 2593 + + K DV+SFG+LLWE++T G P+ +++ + + + L+P +YCP + Sbjct: 1258 QKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQP----EYCPDHLY 1313 Query: 2594 PLIEQCCALQPEKRPDFWQLVKTLEKIQS 2680 ++ +C + E+RP F +LV + I S Sbjct: 1314 EVMLKCWHPKAEQRPSFAELVSRISAIFS 1342
>P06244:KAPA_YEAST cAMP-dependent protein kinase type 1 - Saccharomyces cerevisiae| (Baker's yeast) Length = 397 Score = 110 bits (276), Expect = 3e-23 Identities = 69/238 (28%), Positives = 124/238 (52%) Frame = +2 Query: 1841 MAQAVQSTVDWKLDKAKLLVGHSFASGAHSRLYRGLYDDKPVAIKFIRRPHEDPGGIMAA 2020 +AQA ++ + L ++L S L R ++ + A+K +++ ++ Sbjct: 72 IAQARVTSGKYSLQDFQILRTLGTGSFGRVHLIRSRHNGRYYAMKVLKKEI-----VVRL 126 Query: 2021 KLDKQYNTEINALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPL 2200 K + N E LS + H +I++ T + ++I + + GG L S L + P P+ Sbjct: 127 KQVEHTNDERLMLSIVTHPFIIRMWGTFQDAQQIFMIMDYIEGGELFSLLRKSQRFPNPV 186 Query: 2201 ERTISIALEIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIAXXXXXXXXXXXX 2380 + A E+ LEY+HS+ +++RD+KPENIL D+N +KI DFG A Sbjct: 187 AKFY--AAEVCLALEYLHSKDIIYRDLKPENILLDKNGHIKITDFGFA--KYVPDVTYTL 242 Query: 2381 XGTYRWMAPEMIKRKPYNRKVDVYSFGLLLWEMVTGRIPFENLSPVQVAYAVATDKLK 2554 GT ++APE++ KPYN+ +D +SFG+L++EM+ G PF + + ++ + +L+ Sbjct: 243 CGTPDYIAPEVVSTKPYNKSIDWWSFGILIYEMLAGYTPFYDSNTMKTYEKILNAELR 300
>P24062:IGF1R_RAT Insulin-like growth factor 1 receptor precursor - Rattus norvegicus| (Rat) Length = 1370 Score = 110 bits (276), Expect = 3e-23 Identities = 81/288 (28%), Positives = 136/288 (47%), Gaps = 21/288 (7%) Frame = +2 Query: 1868 DWKLDKAKLLVGHSFASGAHSRLY----RGLYDDKP---VAIKFIRRPHEDPGGIMAAKL 2026 +W++ + K+ + G+ +Y +G+ D+P VAIK + AA + Sbjct: 992 EWEVAREKITMNRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNE---------AASM 1042 Query: 2027 DK--QYNTEINALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHN--PEHR-- 2188 + ++ E + + +V++L+ G +I EL+ G L+SYL + PE Sbjct: 1043 RERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEVENN 1102 Query: 2189 ----PLPLERTISIALEIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIAXXXX 2356 P L + I +A EIA G+ Y+++ VHRD+ N + E+F VKI DFG+ Sbjct: 1103 LVLIPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIY 1162 Query: 2357 XXXXXXXXXG---TYRWMAPEMIKRKPYNRKVDVYSFGLLLWEMVT-GRIPFENLSPVQV 2524 RWM+PE +K + DV+SFG++LWE+ T P++ LS QV Sbjct: 1163 ETDYYRKGGKGLLPVRWMSPESLKDGVFTTHSDVWSFGVVLWEIATLAEQPYQGLSNEQV 1222 Query: 2525 AYAVATDKLKPMDPQDYCPAAVRPLIEQCCALQPEKRPDFWQLVKTLE 2668 V L +D D CP + L+ C P+ RP F +++ +++ Sbjct: 1223 LRFVMEGGL--LDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIIGSIK 1268
>Q04736:YES_MOUSE Proto-oncogene tyrosine-protein kinase Yes - Mus musculus (Mouse)| Length = 541 Score = 110 bits (275), Expect = 3e-23 Identities = 83/300 (27%), Positives = 138/300 (46%), Gaps = 4/300 (1%) Frame = +2 Query: 1781 DNVGRRRVSAVENVRSRTVSMAQAVQSTVDWKLDKAKLLVGHSFASGAHSRLYRGLYDDK 1960 D + + + V+ +T +A+ W++ + L + G ++ G ++ Sbjct: 243 DGLCHKLTTVCPTVKPQTQGLAKDA-----WEIPRESLRLEVKLGQGCFGEVWMGTWNGT 297 Query: 1961 P-VAIKFIRRPHEDPGGIMAAKLDKQYNTEINALSHLYHKNVIKLVATHKCGPVYYIITE 2137 VAIK ++ PG +M + + E + L H ++ L A P+Y I+TE Sbjct: 298 TKVAIKTLK-----PGTMMP----EAFLQEAQIMKKLRHDKLVPLYAVVSEEPIY-IVTE 347 Query: 2138 LLPGGSLRSYLHNPEHRPLPLERTISIALEIARGLEYVHSQGVVHRDIKPENILFDENFE 2317 + GSL +L + + L L + + +A +IA G+ Y+ +HRD++ NIL EN Sbjct: 348 FMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLI 407 Query: 2318 VKIADFGIAXXXXXXXXXXXXXGTY--RWMAPEMIKRKPYNRKVDVYSFGLLLWEMVT-G 2488 KIADFG+A + +W APE + K DV+SFG+L E+VT G Sbjct: 408 CKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKG 467 Query: 2489 RIPFENLSPVQVAYAVATDKLKPMDPQDYCPAAVRPLIEQCCALQPEKRPDFWQLVKTLE 2668 R+P+ + +V V P PQ CP ++ L+ C P++RP F + LE Sbjct: 468 RVPYPGMVNREVLEQVERGYRMPC-PQG-CPESLHELMNLCWKKDPDERPTFEYIQSFLE 525
>O70146:TESK1_MOUSE Dual specificity testis-specific protein kinase 1 - Mus musculus| (Mouse) Length = 627 Score = 110 bits (275), Expect = 3e-23 Identities = 71/243 (29%), Positives = 124/243 (51%), Gaps = 15/243 (6%) Frame = +2 Query: 1991 HEDPGGIMAAKLDK----QYNT--EINALSHLYHKNVIKLVATHKCGPVYYIITELLPGG 2152 H G +M K++K + NT E+ ++ L H N+++ + + +TE + GG Sbjct: 71 HRQSGQVMVLKMNKLPSNRSNTLREVQLMNRLRHPNILRFMGVCVHQGQLHALTEYMNGG 130 Query: 2153 SLRSYLHNPEHRPLPLERTISIALEIARGLEYVHSQGVVHRDIKPENILF---DENFEVK 2323 +L L +PE PL + +AL+IA+GL Y+H++GV HRD+ +N L D F Sbjct: 131 TLEQLLSSPE--PLSWPVRLHLALDIAQGLRYLHAKGVFHRDLTSKNCLVRREDRGFTAV 188 Query: 2324 IADFGIA-----XXXXXXXXXXXXXGTYRWMAPEMIKRKPYNRKVDVYSFGLLLWEMVTG 2488 + DFG+A G+ WMAPE+++ + Y+ K DV++FG++L E++ Sbjct: 189 VGDFGLAEKIPVYREGTRKEPLAVVGSPYWMAPEVLRGELYDEKADVFAFGIVLCELI-A 247 Query: 2489 RIPFE-NLSPVQVAYAVATDKLKPMDPQDYCPAAVRPLIEQCCALQPEKRPDFWQLVKTL 2665 R+P + + P + + + + D CP L CC+++P R F ++ + L Sbjct: 248 RVPADPDYLPRTEDFGLDVPAFRTLVGND-CPLPFLLLAIHCCSMEPSTRAPFTEITQHL 306 Query: 2666 EKI 2674 E+I Sbjct: 307 EQI 309
>Q75DK7:STE20_ASHGO Serine/threonine-protein kinase STE20 - Ashbya gossypii (Yeast)| (Eremothecium gossypii) Length = 971 Score = 110 bits (275), Expect = 3e-23 Identities = 102/407 (25%), Positives = 170/407 (41%), Gaps = 15/407 (3%) Frame = +2 Query: 1388 SPPAKSEKSKAPRARSLVKSPSSMMLLSYLNKAYPNQGS-------SVQNADGSLHKPRS 1546 SP A +S ++ S S S KA N+ S A + +P S Sbjct: 531 SPLAYDSQSATATPKNQRFSNQSSGFFSLARKATLNKNKQQLPPIPSAAAASAPITQPGS 590 Query: 1547 KSPLPSVVPSDTFREARASSQRFTSP----PPKRVGSDKSVYGKSLGREQCDMAASPDWC 1714 + +P + P++ A + S + P PP + D + RE+ Sbjct: 591 TANIPYIKPAENPVSAPSKSIPPSLPAVPTPPPPIEKDPPLRDLERERER---------- 640 Query: 1715 STPVVFGEHSSQKDSSWTRRYFDNVGRRRVSAVENVRSRTVSMAQAVQSTVDWKLDKAKL 1894 EHSS K RRR ++ +A+ K+ + + Sbjct: 641 -------EHSSAKQGQLALERKREEKRRRNQKLQ------AKLAEICSPGDPSKIYRNLV 687 Query: 1895 LVGHSFASGAHSRLYRGLYDDKPVAIKFIRRPHEDPGGIMAAKLDKQYNTEINALSHLYH 2074 +G + G ++ G + VAIK + + ++ EI + H Sbjct: 688 KIGQGASGGVYTAYEIGT--NASVAIKQMNLEKQPKKELII--------NEILVMKGSRH 737 Query: 2075 KNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIALEIARGLEYVH 2254 N++ + ++ ++I E + GGSL + H L + +++ E RGL ++H Sbjct: 738 NNIVNFIDSYLLKGDLWVIMEYMEGGSLTDVV---THCILTEGQIAAVSRETLRGLHFLH 794 Query: 2255 SQGVVHRDIKPENILFDENFEVKIADFGI-AXXXXXXXXXXXXXGTYRWMAPEMIKRKPY 2431 S+GV+HRDIK +NIL + +K+ DFG A GT WMAPE++ RK Y Sbjct: 795 SKGVIHRDIKSDNILLSMDGNIKLTDFGFCAQINETNLKRTTMVGTPYWMAPEVVSRKEY 854 Query: 2432 NRKVDVYSFGLLLWEMVTGRIPFENLSPVQVAYAVATD---KLKPMD 2563 KVD++S G+++ EM+ G P+ N +P++ Y +AT+ KLK D Sbjct: 855 GPKVDIWSLGIMIIEMIEGEPPYLNETPLRALYLIATNGTPKLKDAD 901
>Q60751:IGF1R_MOUSE Insulin-like growth factor 1 receptor precursor - Mus musculus| (Mouse) Length = 1373 Score = 110 bits (275), Expect = 3e-23 Identities = 81/289 (28%), Positives = 136/289 (47%), Gaps = 22/289 (7%) Frame = +2 Query: 1868 DWKLDKAKLLVGHSFASGAHSRLY----RGLYDDKP---VAIKFIRRPHEDPGGIMAAKL 2026 +W++ + K+ + G+ +Y +G+ D+P VAIK + AA + Sbjct: 992 EWEVAREKITMNRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNE---------AASM 1042 Query: 2027 DK--QYNTEINALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHN--PEHR-- 2188 + ++ E + + +V++L+ G +I EL+ G L+SYL + PE Sbjct: 1043 RERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEVEQN 1102 Query: 2189 -----PLPLERTISIALEIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIAXXX 2353 P L + I +A EIA G+ Y+++ VHRD+ N + E+F VKI DFG+ Sbjct: 1103 NLVLIPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDI 1162 Query: 2354 XXXXXXXXXXG---TYRWMAPEMIKRKPYNRKVDVYSFGLLLWEMVT-GRIPFENLSPVQ 2521 RWM+PE +K + DV+SFG++LWE+ T P++ LS Q Sbjct: 1163 YETDYYRKGGKGLLPVRWMSPESLKDGVFTTHSDVWSFGVVLWEIATLAEQPYQGLSNEQ 1222 Query: 2522 VAYAVATDKLKPMDPQDYCPAAVRPLIEQCCALQPEKRPDFWQLVKTLE 2668 V V L +D D CP + L+ C P+ RP F +++ +++ Sbjct: 1223 VLRFVMEGGL--LDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIIGSIK 1269
>P48562:CLA4_YEAST Serine/threonine-protein kinase CLA4 - Saccharomyces cerevisiae| (Baker's yeast) Length = 842 Score = 110 bits (275), Expect = 3e-23 Identities = 60/211 (28%), Positives = 104/211 (49%), Gaps = 7/211 (3%) Frame = +2 Query: 2045 EINALSHLYHKNVIKLVATH-KCGPVYYIITELLPGGSLRSYLHNP-----EHRPLPLER 2206 EI + HKN++ + + + +++ E + GGSL + N H PL + Sbjct: 610 EILVMKDSRHKNIVNFLEAYLRTDDDLWVVMEFMEGGSLTDIIENSPTNDNSHSPLTEPQ 669 Query: 2207 TISIALEIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGI-AXXXXXXXXXXXXX 2383 I E +GL+++H + ++HRDIK +N+L D VKI DFG A Sbjct: 670 IAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRARVKITDFGFCARLTDKRSKRATMV 729 Query: 2384 GTYRWMAPEMIKRKPYNRKVDVYSFGLLLWEMVTGRIPFENLSPVQVAYAVATDKLKPMD 2563 GT WMAPE++K++ Y+ K+DV+S G++ EM+ G P+ N P++ Y +AT+ + Sbjct: 730 GTPYWMAPEVVKQREYDEKIDVWSLGIMTIEMLEGEPPYLNEDPLKALYLIATNGTPKLK 789 Query: 2564 PQDYCPAAVRPLIEQCCALQPEKRPDFWQLV 2656 + ++ + C + R +L+ Sbjct: 790 HPESLSLEIKRFLSVCLCVDVRYRASTEELL 820
>O70405:ULK1_MOUSE Serine/threonine-protein kinase ULK1 - Mus musculus (Mouse)| Length = 1051 Score = 110 bits (274), Expect = 5e-23 Identities = 80/265 (30%), Positives = 126/265 (47%), Gaps = 13/265 (4%) Frame = +2 Query: 1889 KLLVGHSFASGAHSRLYRGLYDDK---PVAIKFIRRPHEDPGGIMAAKLDKQYNTEINAL 2059 K L+GH GA + +++G + +K VA+K I + + AK EI L Sbjct: 19 KDLIGH----GAFAVVFKGRHREKHDLEVAVKCINKKN-------LAKSQTLLGKEIKIL 67 Query: 2060 SHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIALEIARG 2239 L H+N++ L + Y++ E GG L YLH R L + +IA Sbjct: 68 KELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHTM--RTLSEDTVRLFLQQIAGA 125 Query: 2240 LEYVHSQGVVHRDIKPENILFDE---------NFEVKIADFGIAXXXXXXXXXXXXXGTY 2392 + +HS+G++HRD+KP+NIL N VKIADFG A G+ Sbjct: 126 MRLLHSKGIIHRDLKPQNILLSNPGGRRANPSNIRVKIADFGFARYLQSNMMAATLCGSP 185 Query: 2393 RWMAPEMIKRKPYNRKVDVYSFGLLLWEMVTGRIPFENLSPVQVAYAVATDK-LKPMDPQ 2569 +MAPE+I + Y+ K D++S G ++++ +TG+ PF+ SP + +K L P P+ Sbjct: 186 MYMAPEVIMSQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLVPAIPR 245 Query: 2570 DYCPAAVRPLIEQCCALQPEKRPDF 2644 + A +R L+ + R DF Sbjct: 246 E-TSAPLRQLLLALLQRNHKDRMDF 269
>Q62829:PAK3_RAT Serine/threonine-protein kinase PAK 3 - Rattus norvegicus (Rat)| Length = 544 Score = 110 bits (274), Expect = 5e-23 Identities = 107/432 (24%), Positives = 190/432 (43%), Gaps = 12/432 (2%) Frame = +2 Query: 1400 KSEKSKAPRA-RSLVKSPSSMMLLSYLNKAYPNQGSSVQNADGSLHKPRSKSPLPSVVP- 1573 K E+ K P+A ++K S ++ N+ Y + S ++A G + +S + S P Sbjct: 109 KLEQKKNPQAVLDVLKFYDSKETVN--NQKYMSFTSGDKSAHGYIAAHQSNTKTASEPPL 166 Query: 1574 ----SDTFREARASSQRFTSPPP---KRVGSDKSVYGKSLGREQCDMAASPDWCSTPVVF 1732 S+ E + PPP R KS+Y +S+ E A+P+ +TP Sbjct: 167 APPVSEEEDEEEEEEEDDNEPPPVIAPRPEHTKSIYTRSVV-ESIASPAAPNKEATPP-- 223 Query: 1733 GEHSSQKDSSWTRRYFDNVGRRRVSAVENVRSRTVSMAQAVQSTVDWKLDKAKLLVGHSF 1912 S++ +S T + N R+R + + + + ++S V K K Sbjct: 224 ---SAENANSST--LYRNTDRQRKKS----KMTDEEILEKLRSIVSVGDPKKKYTRFEKI 274 Query: 1913 ASGAHSRLYRGL--YDDKPVAIKFIRRPHEDPGGIMAAKLDKQYNTEINALSHLYHKNVI 2086 GA +Y L + VAIK + + ++ EI + + N++ Sbjct: 275 GQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELII--------NEILVMRENKNPNIV 326 Query: 2087 KLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIALEIARGLEYVHSQGV 2266 + ++ G +++ E L GGSL + + + ++ E + L+++HS V Sbjct: 327 NYLDSYLVGDELWVVMEYLAGGSLTDVV---TETCMDEGQIAAVCRECLQALDFLHSNQV 383 Query: 2267 VHRDIKPENILFDENFEVKIADFGI-AXXXXXXXXXXXXXGTYRWMAPEMIKRKPYNRKV 2443 +HRDIK +NIL + VK+ DFG A GT WMAPE++ RK Y KV Sbjct: 384 IHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKV 443 Query: 2444 DVYSFGLLLWEMVTGRIPFENLSPVQVAYAVATDKLKPMDPQDYCPAAVRPLIEQCCALQ 2623 D++S G++ EMV G P+ N +P++ Y +AT+ + + A R + +C + Sbjct: 444 DIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMD 503 Query: 2624 PEKRPDFWQLVK 2659 ++R +L++ Sbjct: 504 VDRRGSAKELLQ 515
>P53671:LIMK2_HUMAN LIM domain kinase 2 - Homo sapiens (Human)| Length = 638 Score = 110 bits (274), Expect = 5e-23 Identities = 74/273 (27%), Positives = 121/273 (44%), Gaps = 33/273 (12%) Frame = +2 Query: 1979 IRRPHEDPGGIMAAK--------LDKQYNTEINALSHLYHKNVIKLVATHKCGPVYYIIT 2134 I+ H+ G +M K K + TE+ + L H NV+K + ++T Sbjct: 346 IKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLT 405 Query: 2135 ELLPGGSLRSYLHNPEHRPLPLERTISIALEIARGLEYVHSQGVVHRDIKPENILFDENF 2314 E + GG+L+ +L + + P P ++ + A IA G+ Y+HS ++HRD+ N L + Sbjct: 406 EYIEGGTLKDFLRSMD--PFPWQQKVRFAKGIASGMAYLHSMCIIHRDLNSHNCLIKLDK 463 Query: 2315 EVKIADFGIA---------------------XXXXXXXXXXXXXGTYRWMAPEMIKRKPY 2431 V +ADFG++ G WMAPEM+ K Y Sbjct: 464 TVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVVGNPYWMAPEMLNGKSY 523 Query: 2432 NRKVDVYSFGLLLWEMVTGRIPFENLSPVQVAYAVAT----DKLKPMDPQDYCPAAVRPL 2599 + VD++SFG++L E++ + P + + + +K P D CP A PL Sbjct: 524 DETVDIFSFGIVLCEIIGQVYADPDCLPRTLDFGLNVKLFWEKFVPTD----CPPAFFPL 579 Query: 2600 IEQCCALQPEKRPDFWQLVKTLEKIQSVMSQGG 2698 CC L+PE RP F +L + E + + + G Sbjct: 580 AAICCRLEPESRPAFSKLEDSFEALSLYLGELG 612
>Q07292:KRAF1_CAEEL Raf homolog serine/threonine-protein kinase - Caenorhabditis elegans| Length = 813 Score = 110 bits (274), Expect = 5e-23 Identities = 80/282 (28%), Positives = 137/282 (48%), Gaps = 13/282 (4%) Frame = +2 Query: 1868 DWKLDKAKLLVGHSFASGAHSRLYRGLYDDKPVAIKFIRRPHEDPGGIMAAKLDKQYNTE 2047 DW++ + ++ + SG+ +YRG + VAIK + P + A K E Sbjct: 473 DWEILPNEFIIQYKVGSGSFGTVYRGEFFGT-VAIKKLNVVDPTPSQMAAFK------NE 525 Query: 2048 INALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHR-PLPLERTISIAL 2224 + L H NV+ + + P IIT+ G SL ++H E R + I I Sbjct: 526 VAVLKKTRHLNVLLFMGWVR-EPEIAIITQWCEGSSLYRHIHVQEPRVEFEMGAIIDILK 584 Query: 2225 EIARGLEYVHSQGVVHRDIKPENI-LFDENFEVKIADFGIA-----XXXXXXXXXXXXXG 2386 +++ G+ Y+HS+ ++HRD+K NI L D+ VKI DFG+A G Sbjct: 585 QVSLGMNYLHSKNIIHRDLKTNNIFLMDDMSTVKIGDFGLATVKTKWTVNGGQQQQQPTG 644 Query: 2387 TYRWMAPEMIKRK---PYNRKVDVYSFGLLLWEMVTGRIPFENL-SPVQVAYAVATDKLK 2554 + WMAPE+I+ + PY + DVYSFG+ ++E+++ +P+ N+ + Q+ + V L+ Sbjct: 645 SILWMAPEVIRMQDDNPYTPQSDVYSFGICMYEILSSHLPYSNINNRDQILFMVGRGYLR 704 Query: 2555 P--MDPQDYCPAAVRPLIEQCCALQPEKRPDFWQLVKTLEKI 2674 P + P ++ L + C +RP F ++++ L I Sbjct: 705 PDRSKIRHDTPKSMLKLYDNCIMFDRNERPVFGEVLERLRDI 746
>P22182:FGFR1_XENLA Fibroblast growth factor receptor 1 precursor - Xenopus laevis| (African clawed frog) Length = 812 Score = 110 bits (274), Expect = 5e-23 Identities = 88/311 (28%), Positives = 151/311 (48%), Gaps = 32/311 (10%) Frame = +2 Query: 1871 WKLDKAKLLVGHSFASGAHSRLYR----GLYDDKP-----VAIKFIRRPHEDPGGIMAAK 2023 W++ + +L++G G ++ GL +KP VA+K ++ + Sbjct: 465 WEVARDRLILGKPLGEGCFGQVVMAEAIGLDKEKPNKVTKVAVKMLKSDASE-------- 516 Query: 2024 LDKQYNTEINALSHLY----HKNVIKLV-ATHKCGPVYYIITELLPGGSLRSYL------ 2170 K + I+ + + HKN+I L+ A + GP+Y +I E G+LR YL Sbjct: 517 --KDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLY-VIVEYTSKGNLREYLRARRPP 573 Query: 2171 -----HNPEHRP---LPLERTISIALEIARGLEYVHSQGVVHRDIKPENILFDENFEVKI 2326 +NP P L + +S A ++ARG++Y+ S+ +HRD+ N+L E+ +KI Sbjct: 574 AMEYCYNPTCVPDQLLSFKDLVSCAYQVARGMDYLASKKCIHRDLAARNVLVTEDNIMKI 633 Query: 2327 ADFGIAXXXXXXXXXXXXXG---TYRWMAPEMIKRKPYNRKVDVYSFGLLLWEMVT-GRI 2494 ADFG+A +WMAPE + + Y + DV+SFG+LLWE+ T G Sbjct: 634 ADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGS 693 Query: 2495 PFENLSPVQVAYAVATDKLKPMDPQDYCPAAVRPLIEQCCALQPEKRPDFWQLVKTLEKI 2674 P+ + P++ + + + + MD C + +++ C P +RP F QLV+ L++I Sbjct: 694 PYPGV-PMEELFKLLKEGHR-MDKPTNCTNELYMMMKDCWHAMPSQRPTFNQLVEDLDRI 751 Query: 2675 QSVMSQGGSLD 2707 ++ S LD Sbjct: 752 LALSSNQEYLD 762
>P42681:TXK_HUMAN Tyrosine-protein kinase TXK - Homo sapiens (Human)| Length = 527 Score = 109 bits (273), Expect = 6e-23 Identities = 77/272 (28%), Positives = 131/272 (48%), Gaps = 4/272 (1%) Frame = +2 Query: 1871 WKLDKAKLLVGHSFASGAHSRLYRGLYDDK-PVAIKFIRRPHEDPGGIMAAKLDKQYNTE 2047 W++D ++L SG ++ G + VAIK I G M+ ++ + E Sbjct: 264 WEIDPSELAFIKEIGSGQFGVVHLGEWRSHIQVAIKAINE------GSMS---EEDFIEE 314 Query: 2048 INALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIALE 2227 + L H +++L YI+TE + G L +YL + + L E +S+ + Sbjct: 315 AKVMMKLSHSKLVQLYGVCIQRKPLYIVTEFMENGCLLNYLRENKGK-LRKEMLLSVCQD 373 Query: 2228 IARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIAXXXXXXXXXXXXXGTY--RWM 2401 I G+EY+ G +HRD+ N L VKI+DFG+ + +W Sbjct: 374 ICEGMEYLERNGYIHRDLAARNCLVSSTCIVKISDFGMTRYVLDDEYVSSFGAKFPIKWS 433 Query: 2402 APEMIKRKPYNRKVDVYSFGLLLWEMVT-GRIPFENLSPVQVAYAVATDKLKPMDPQDYC 2578 PE+ Y+ K DV+SFG+L+WE+ T G++PFEN S +QV A+ ++ + P Sbjct: 434 PPEVFLFNKYSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAI-SEGFRLYRPH-LA 491 Query: 2579 PAAVRPLIEQCCALQPEKRPDFWQLVKTLEKI 2674 P ++ ++ C +PE RP F +L++ + +I Sbjct: 492 PMSIYEVMYSCWHEKPEGRPTFAELLRAVTEI 523
>Q96S53:TESK2_HUMAN Dual specificity testis-specific protein kinase 2 - Homo sapiens| (Human) Length = 571 Score = 109 bits (273), Expect = 6e-23 Identities = 72/246 (29%), Positives = 121/246 (49%), Gaps = 12/246 (4%) Frame = +2 Query: 1991 HEDPGGIMAAKLDKQYNT------EINALSHLYHKNVIKLVATHKCGPVYYIITELLPGG 2152 H G +MA K++ + E+ ++ L H N+++ + + +TE + G Sbjct: 77 HRASGQVMALKMNTLSSNRANMLKEVQLMNRLSHPNILRFMGVCVHQGQLHALTEYINSG 136 Query: 2153 SLRSYLHNPEHRPLPLERTISIALEIARGLEYVHSQGVVHRDIKPENILF--DEN-FEVK 2323 +L L + H LP + +A +IA GL Y+H +G+ HRD+ +N L DEN + Sbjct: 137 NLEQLLDSNLH--LPWTVRVKLAYDIAVGLSYLHFKGIFHRDLTSKNCLIKRDENGYSAV 194 Query: 2324 IADFGIAXXXXXXXXXXXXX---GTYRWMAPEMIKRKPYNRKVDVYSFGLLLWEMVTGRI 2494 +ADFG+A G+ WMAPE+++ +PYN K DV+S+G++L E++ Sbjct: 195 VADFGLAEKIPDVSMGSEKLAVVGSPFWMAPEVLRDEPYNEKADVFSYGIILCEIIARIQ 254 Query: 2495 PFENLSPVQVAYAVATDKLKPMDPQDYCPAAVRPLIEQCCALQPEKRPDFWQLVKTLEKI 2674 + P + + D + M CP L CC + P+ RP F ++ KTLE+I Sbjct: 255 ADPDYLPRTENFGLDYDAFQHMVGD--CPPDFLQLTFNCCNMDPKLRPSFVEIGKTLEEI 312 Query: 2675 QSVMSQ 2692 S + + Sbjct: 313 LSRLQE 318
>Q63572:TESK1_RAT Dual specificity testis-specific protein kinase 1 - Rattus norvegicus| (Rat) Length = 628 Score = 109 bits (273), Expect = 6e-23 Identities = 71/243 (29%), Positives = 124/243 (51%), Gaps = 15/243 (6%) Frame = +2 Query: 1991 HEDPGGIMAAKLDK----QYNT--EINALSHLYHKNVIKLVATHKCGPVYYIITELLPGG 2152 H G +M K++K + NT E+ ++ L H N+++ + + +TE + GG Sbjct: 71 HRQSGQVMVLKMNKLPSNRSNTLREVQLMNRLRHPNILRFMGVCVHQGQLHALTEYMNGG 130 Query: 2153 SLRSYLHNPEHRPLPLERTISIALEIARGLEYVHSQGVVHRDIKPENILF---DENFEVK 2323 +L L +PE PL + +AL+IA+GL Y+H++GV HRD+ +N L D F Sbjct: 131 TLEQLLSSPE--PLSWPVRLHLALDIAQGLRYLHAKGVFHRDLTSKNCLVRREDGGFTAV 188 Query: 2324 IADFGIA-----XXXXXXXXXXXXXGTYRWMAPEMIKRKPYNRKVDVYSFGLLLWEMVTG 2488 + DFG+A G+ WMAPE+++ + Y+ K DV++FG++L E++ Sbjct: 189 VGDFGLAEKIPVYREGARKEPLAVVGSPYWMAPEVLRGELYDEKADVFAFGIVLCELI-A 247 Query: 2489 RIPFE-NLSPVQVAYAVATDKLKPMDPQDYCPAAVRPLIEQCCALQPEKRPDFWQLVKTL 2665 R+P + + P + + + + D CP L CC+++P R F ++ + L Sbjct: 248 RVPADPDYLPRTEDFGLDVPAFRTLVGND-CPLPFLLLAIHCCSMEPSARAPFTEITQHL 306 Query: 2666 EKI 2674 E+I Sbjct: 307 EQI 309
>Q9P286:PAK7_HUMAN Serine/threonine-protein kinase PAK 7 - Homo sapiens (Human)| Length = 719 Score = 109 bits (273), Expect = 6e-23 Identities = 57/172 (33%), Positives = 95/172 (55%), Gaps = 1/172 (0%) Frame = +2 Query: 2045 EINALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIAL 2224 E+ + +H NV+ + +++ G +++ E L GG+L + H + E+ ++ L Sbjct: 494 EVVIMRDYHHDNVVDMYSSYLVGDELWVVMEFLEGGALTDIV---THTRMNEEQIATVCL 550 Query: 2225 EIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGI-AXXXXXXXXXXXXXGTYRWM 2401 + R L Y+H+QGV+HRDIK ++IL + +K++DFG A GT WM Sbjct: 551 SVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWM 610 Query: 2402 APEMIKRKPYNRKVDVYSFGLLLWEMVTGRIPFENLSPVQVAYAVATDKLKP 2557 APE+I R PY +VD++S G+++ EM+ G P+ N P+Q + D L P Sbjct: 611 APEVISRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRI-RDSLPP 661
>Q91288:FGFR4_PLEWA Fibroblast growth factor receptor 4 precursor - Pleurodeles waltlii| (Iberian ribbed newt) Length = 822 Score = 109 bits (273), Expect = 6e-23 Identities = 83/305 (27%), Positives = 145/305 (47%), Gaps = 31/305 (10%) Frame = +2 Query: 1871 WKLDKAKLLVGHSFASGAHSRLYR----GLYDDKP-----VAIKFIRRPHEDPGGIMAAK 2023 W+ + +L++G G ++ R G+ D+P VAIK ++ D G Sbjct: 479 WEFPRERLVLGKPLGEGCFGQVVRAEAYGINKDQPDKAITVAIKIVK----DKG------ 528 Query: 2024 LDKQYNTEINALSHLY----HKNVIKLVATHKCGPVYYIITELLPGGSLRSYLH-----N 2176 DK+ + I+ + + HKN+I L+ Y+I E G+LR +L + Sbjct: 529 TDKELSDLISEMELMKLMGKHKNIINLLGVCTQDGPLYMIVEYASKGNLREFLRARRPPS 588 Query: 2177 PEH---------RPLPLERTISIALEIARGLEYVHSQGVVHRDIKPENILFDENFEVKIA 2329 P++ L + +S + ++ARG+ Y+ S+ +HRD+ N+L +KIA Sbjct: 589 PDYTFDMTKVPEEQLSFQDLVSCSYQVARGMAYLESKRCIHRDLAARNVLVTGENVMKIA 648 Query: 2330 DFGIAXXXXXXXXXXXXXG---TYRWMAPEMIKRKPYNRKVDVYSFGLLLWEMVT-GRIP 2497 DFG+A +WMAPE + + Y + DV+SFG+L WE+ T G P Sbjct: 649 DFGLARGVHDIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLTWEIFTLGGSP 708 Query: 2498 FENLSPVQVAYAVATDKLKPMDPQDYCPAAVRPLIEQCCALQPEKRPDFWQLVKTLEKIQ 2677 + + PV+ + + + + MD C + L+ +C P +RP F QLV+TL++I Sbjct: 709 YPGI-PVEELFKLLREGHR-MDKPSNCTHELYMLMRECWHAAPSQRPTFKQLVETLDRIL 766 Query: 2678 SVMSQ 2692 + +++ Sbjct: 767 ATVAE 771
>O59790:ARK1_SCHPO Serine/threonine-protein kinase ark1 - Schizosaccharomyces pombe| (Fission yeast) Length = 355 Score = 109 bits (273), Expect = 6e-23 Identities = 77/255 (30%), Positives = 122/255 (47%), Gaps = 1/255 (0%) Frame = +2 Query: 1898 VGHSFASGAHSRLYRGLYDDKPVAIKFIRRPHEDPGGIMAAKLDKQYNTEINALSHLYHK 2077 +G G R+Y + K I ++ H+ ++ +K++KQ EI S+L HK Sbjct: 91 IGKPLGKGKFGRVYLAK-EKKTGFIVALKTLHKSE--LVQSKIEKQVRREIEIQSNLRHK 147 Query: 2078 NVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIALEIARGLEYVHS 2257 N+++L Y+I E G L Y H + E ++A L Y+H Sbjct: 148 NILRLYGHFHDEKRIYLILEFAGRGEL--YQHLRRAKRFSEEVASKYIFQMANALSYLHK 205 Query: 2258 QGVVHRDIKPENILFDENFEVKIADFGIAXXXXXXXXXXXXXGTYRWMAPEMIKRKPYNR 2437 + V+HRDIKPENIL + E+K++DFG + GT ++ PEM++ K + Sbjct: 206 KHVIHRDIKPENILLGIDGEIKLSDFGWS-VHAPSNRRTTLCGTLDYLPPEMVEGKEHTE 264 Query: 2438 KVDVYSFGLLLWEMVTGRIPFENLSPVQVAY-AVATDKLKPMDPQDYCPAAVRPLIEQCC 2614 KVD++S G+L +E + G PFE++S Y +A LK + P R LI + Sbjct: 265 KVDLWSLGVLTYEFLVGAPPFEDMSGHSATYKRIAKVDLK---IPSFVPPDARDLISRLL 321 Query: 2615 ALQPEKRPDFWQLVK 2659 PEKR Q+++ Sbjct: 322 QHNPEKRMSLEQVMR 336
>P27447:YES_XIPHE Tyrosine-protein kinase Yes - Xiphophorus helleri| Length = 544 Score = 109 bits (272), Expect = 8e-23 Identities = 75/270 (27%), Positives = 126/270 (46%), Gaps = 4/270 (1%) Frame = +2 Query: 1871 WKLDKAKLLVGHSFASGAHSRLYRGLYDDKP-VAIKFIRRPHEDPGGIMAAKLDKQYNTE 2047 W++ + L + G ++ G ++ VAIK ++ P + E Sbjct: 271 WEIPRESLRLDVRLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMSPEAFLE---------E 321 Query: 2048 INALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIALE 2227 + L H ++ L A P+Y I+TE + GSL +L + + L L + + +A + Sbjct: 322 AQIMKKLRHDKLVPLYAVVSEEPIY-IVTEFMGKGSLLDFLKEGDGKHLKLPQLVDMASQ 380 Query: 2228 IARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIAXXXXXXXXXXXXXGTY--RWM 2401 IA G+ ++ +HRD++ NIL +N KIADFG+A + +W Sbjct: 381 IADGMAFIERMNYIHRDLRAANILVADNLVCKIADFGLARLIEDNEYTARQGAKFPIKWT 440 Query: 2402 APEMIKRKPYNRKVDVYSFGLLLWEMVT-GRIPFENLSPVQVAYAVATDKLKPMDPQDYC 2578 APE + K DV+SFG+LL E+VT GR+P+ + +V V D+ M C Sbjct: 441 APEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMVNREVLEQV--DRGYRMPCPQGC 498 Query: 2579 PAAVRPLIEQCCALQPEKRPDFWQLVKTLE 2668 P ++ ++ QC +P++RP F + LE Sbjct: 499 PESLHEMMRQCWKKEPDERPTFEYIQSFLE 528
>P10421:MOS_MSVTS Serine/threonine-protein kinase-transforming protein mos -| Myeloproliferative sarcoma virus (isolate ts159) Length = 342 Score = 109 bits (272), Expect = 8e-23 Identities = 73/248 (29%), Positives = 121/248 (48%), Gaps = 16/248 (6%) Frame = +2 Query: 1862 TVDWKLDKAKLLVGHSFASGAHSRLYRGLYDDKPVAIKFIRRPHEDPGGIMAAKLDKQYN 2041 ++DW+ ++ + H SG +Y+ Y PVAIK + + +D + A++ + + Sbjct: 57 SIDWE----QVCLMHRLGSGGFGSVYKATYHGVPVAIKQVNKCTKD---LRASQ--RSFW 107 Query: 2042 TEINALSHLYHKNVIKLVATHKCGP-----VYYIITELLPGGSLRSYLHNPEHRPLPLE- 2203 E+N ++ L H N++++VA P + II E +L ++ P PL Sbjct: 108 AELN-IARLRHDNIVRVVAASTRTPEDSNSLGTIIMEFGGNVTLHQVIYGATRSPEPLSC 166 Query: 2204 -------RTISIALEIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIA---XXX 2353 + + +L++ GL ++HSQ ++H D+KP NIL E KI+DFG + Sbjct: 167 REQLSLGKCLKYSLDVVNGLLFLHSQSILHLDLKPANILISEQDVCKISDFGCSQKLQDL 226 Query: 2354 XXXXXXXXXXGTYRWMAPEMIKRKPYNRKVDVYSFGLLLWEMVTGRIPFENLSPVQVAYA 2533 GTY APE++K + K D+YSFG+ LW+M T +P+ P V YA Sbjct: 227 RCRQSPHHIGGTYTHQAPEILKGEIATPKADIYSFGITLWQMTTREVPYSG-EPQYVQYA 285 Query: 2534 VATDKLKP 2557 V L+P Sbjct: 286 VVAYNLRP 293
>P00537:MOS_MSVMM Serine/threonine-protein kinase-transforming protein mos - Moloney| murine sarcoma virus (strain m1) Length = 376 Score = 109 bits (272), Expect = 8e-23 Identities = 73/249 (29%), Positives = 121/249 (48%), Gaps = 17/249 (6%) Frame = +2 Query: 1862 TVDWKLDKAKLLVGHSFASGAHSRLYRGLYDDKPVAIKFIRRPHEDPGGIMAAKLDKQYN 2041 ++DW+ ++ + H SG +Y+ Y PVAIK + + +D + A++ + + Sbjct: 88 SIDWE----QVCLMHRLGSGGFGSVYKATYHGVPVAIKQVNKCTKD---LRASQ--RSFW 138 Query: 2042 TEINALSHLYHKNVIKLVATHKCGP-----VYYIITELLPGGSLRSYLHNPEHRPLPLE- 2203 E+N ++ L H N++++VA P + II E +L ++ P PL Sbjct: 139 AELN-IARLRHDNIVRVVAASTRTPEDSNSLGTIIMEFGGNVTLHQVIYGATRSPEPLSC 197 Query: 2204 -------RTISIALEIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFG----IAXX 2350 + + +L++ GL ++HSQ ++H D+KP NIL E KI+DFG + Sbjct: 198 REQLSLGKCLKYSLDVVNGLLFLHSQSILHLDLKPANILISEQDVCKISDFGCSQKLQDL 257 Query: 2351 XXXXXXXXXXXGTYRWMAPEMIKRKPYNRKVDVYSFGLLLWEMVTGRIPFENLSPVQVAY 2530 GTY APE++K + K D+YSFG+ LW+M T +P+ P V Y Sbjct: 258 RCRQASPHHIGGTYTHQAPEILKGEIATPKADIYSFGITLWQMTTREVPYSG-EPQYVQY 316 Query: 2531 AVATDKLKP 2557 AV L+P Sbjct: 317 AVVAYNLRP 325
>P07331:MOS_MSVMH Serine/threonine-protein kinase-transforming protein mos - Moloney| murine sarcoma virus (strain HT-1) Length = 374 Score = 109 bits (272), Expect = 8e-23 Identities = 73/249 (29%), Positives = 121/249 (48%), Gaps = 17/249 (6%) Frame = +2 Query: 1862 TVDWKLDKAKLLVGHSFASGAHSRLYRGLYDDKPVAIKFIRRPHEDPGGIMAAKLDKQYN 2041 ++DW+ ++ + H SG +Y+ Y PVAIK + + +D + A++ + + Sbjct: 88 SIDWE----QVCLMHRLGSGGFGSVYKATYHGVPVAIKQVNKCTKD---LRASQ--RSFW 138 Query: 2042 TEINALSHLYHKNVIKLVATHKCGP-----VYYIITELLPGGSLRSYLHNPEHRPLPLE- 2203 E+N ++ L H N++++VA P + II E +L ++ P PL Sbjct: 139 AELN-IARLRHDNIVRVVAASTRTPEDSNSLGTIIMEFGGNVTLHQVIYGATRSPEPLSC 197 Query: 2204 -------RTISIALEIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFG----IAXX 2350 + + +L++ GL ++HSQ ++H D+KP NIL E KI+DFG + Sbjct: 198 REQLSLGKCLKYSLDVVNGLLFLHSQSILHLDLKPANILISEQDVCKISDFGCSQKLQDL 257 Query: 2351 XXXXXXXXXXXGTYRWMAPEMIKRKPYNRKVDVYSFGLLLWEMVTGRIPFENLSPVQVAY 2530 GTY APE++K + K D+YSFG+ LW+M T +P+ P V Y Sbjct: 258 RCRQASPHHIGGTYTHQAPEILKGEIATPKADIYSFGITLWQMTTREVPYSG-EPQYVQY 316 Query: 2531 AVATDKLKP 2557 AV L+P Sbjct: 317 AVVAYNLRP 325
>P00536:MOS_MOUSE Proto-oncogene serine/threonine-protein kinase mos - Mus musculus| (Mouse) Length = 390 Score = 109 bits (272), Expect = 8e-23 Identities = 73/249 (29%), Positives = 121/249 (48%), Gaps = 17/249 (6%) Frame = +2 Query: 1862 TVDWKLDKAKLLVGHSFASGAHSRLYRGLYDDKPVAIKFIRRPHEDPGGIMAAKLDKQYN 2041 ++DW+ ++ + H SG +Y+ Y PVAIK + + +D + A++ + + Sbjct: 104 SIDWE----QVCLMHRLGSGGFGSVYKATYHGVPVAIKQVNKCTKD---LRASQ--RSFW 154 Query: 2042 TEINALSHLYHKNVIKLVATHKCGP-----VYYIITELLPGGSLRSYLHNPEHRPLPLE- 2203 E+N ++ L H N++++VA P + II E +L ++ P PL Sbjct: 155 AELN-IARLRHDNIVRVVAASTRTPEDSNSLGTIIMEFGGNVTLHQVIYGATRSPEPLSC 213 Query: 2204 -------RTISIALEIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFG----IAXX 2350 + + +L++ GL ++HSQ ++H D+KP NIL E KI+DFG + Sbjct: 214 REQLSLGKCLKYSLDVVNGLLFLHSQSILHLDLKPANILISEQDVCKISDFGCSQKLQVL 273 Query: 2351 XXXXXXXXXXXGTYRWMAPEMIKRKPYNRKVDVYSFGLLLWEMVTGRIPFENLSPVQVAY 2530 GTY APE++K + K D+YSFG+ LW+M T +P+ P V Y Sbjct: 274 RCRQASPHHIGGTYTHQAPEILKGEIATPKADIYSFGITLWQMTTREVPYSG-EPQYVQY 332 Query: 2531 AVATDKLKP 2557 AV L+P Sbjct: 333 AVVAYNLRP 341
>Q32L23:LIMK2_BOVIN LIM domain kinase 2 - Bos taurus (Bovine)| Length = 638 Score = 109 bits (272), Expect = 8e-23 Identities = 68/244 (27%), Positives = 109/244 (44%), Gaps = 21/244 (8%) Frame = +2 Query: 2030 KQYNTEINALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERT 2209 K + TE+ + L H NV+K + ++TE + GG+L+ +L N + P P ++ Sbjct: 371 KTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRNVD--PFPWQQK 428 Query: 2210 ISIALEIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIA--------------- 2344 + A IA G+ Y+HS ++HRD+ N L + V +ADFG++ Sbjct: 429 VRFAKGIASGMAYLHSMCIIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKKPPVEKA 488 Query: 2345 ------XXXXXXXXXXXXXGTYRWMAPEMIKRKPYNRKVDVYSFGLLLWEMVTGRIPFEN 2506 G WMAPEM+ K Y+ VDV+SFG++L E++ + Sbjct: 489 TTKKRTLRKSDRKKRYTVVGNPYWMAPEMLNGKSYDETVDVFSFGIVLCEIIGQVYADPD 548 Query: 2507 LSPVQVAYAVATDKLKPMDPQDYCPAAVRPLIEQCCALQPEKRPDFWQLVKTLEKIQSVM 2686 P + + + + CP A PL CC L+PE RP F +L E + + Sbjct: 549 CLPRTLDFGLNVKLFWEKFVPEECPPAFFPLAAICCRLEPESRPAFSKLEDFFEALSLYL 608 Query: 2687 SQGG 2698 + G Sbjct: 609 GELG 612
>P06213:INSR_HUMAN Insulin receptor precursor - Homo sapiens (Human)| Length = 1382 Score = 109 bits (272), Expect = 8e-23 Identities = 78/288 (27%), Positives = 130/288 (45%), Gaps = 21/288 (7%) Frame = +2 Query: 1868 DWKLDKAKLLVGHSFASGAHSRLYRGLYDD-------KPVAIKFIRRPHEDPGGIMAAKL 2026 +W++ + K+ + G+ +Y G D VA+K + +A L Sbjct: 1015 EWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNE---------SASL 1065 Query: 2027 DK--QYNTEINALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYL--------HN 2176 + ++ E + + +V++L+ G ++ EL+ G L+SYL +N Sbjct: 1066 RERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENN 1125 Query: 2177 PEHRPLPLERTISIALEIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIAXXXX 2356 P P L+ I +A EIA G+ Y++++ VHRD+ N + +F VKI DFG+ Sbjct: 1126 PGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIY 1185 Query: 2357 XXXXXXXXXG---TYRWMAPEMIKRKPYNRKVDVYSFGLLLWEMVT-GRIPFENLSPVQV 2524 RWMAPE +K + D++SFG++LWE+ + P++ LS QV Sbjct: 1186 ETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQV 1245 Query: 2525 AYAVATDKLKPMDPQDYCPAAVRPLIEQCCALQPEKRPDFWQLVKTLE 2668 V +D D CP V L+ C P+ RP F ++V L+ Sbjct: 1246 LKFVMDGGY--LDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLLK 1291
>Q26614:FGFR_STRPU Fibroblast growth factor receptor precursor - Strongylocentrotus| purpuratus (Purple sea urchin) Length = 972 Score = 109 bits (272), Expect = 8e-23 Identities = 89/334 (26%), Positives = 162/334 (48%), Gaps = 28/334 (8%) Frame = +2 Query: 1790 GRRRVSAVENVRSRTVSMAQAVQSTVDWKLDKAKLLVGHSFASGAHSRLYRG-----LYD 1954 GR R+++ S TV + +W+ + +L VG + GA ++ G + Sbjct: 610 GRNRLTS-----SLTVISEYDIPLDPEWEFPRDRLTVGKTIGEGAFGKVVIGEAVGIVCQ 664 Query: 1955 DKP--VAIKFIRRPHEDPGGIMAAKLDKQYNTEINALSHLY----HKNVIKLVATHKCGP 2116 +K VA+K ++ A +D++++ I+ L+ + + N+I L+ Sbjct: 665 EKTSTVAVKMLK----------ANAMDREFSDLISELAMMKMIGKNPNIINLLGCCTQEG 714 Query: 2117 VYYIITELLPGGSLRSYLHN---PEH----------RPLPLERTISIALEIARGLEYVHS 2257 Y+I E G+LR +L + PE + L + +S+A ++ARG++++ S Sbjct: 715 PPYVIVEFAHHGNLRDFLRSRRPPEEYEKSILLTTSQTLTNKDLMSMAYQVARGMDFLAS 774 Query: 2258 QGVVHRDIKPENILFDENFEVKIADFGIAXXXXXXXXXXXXXG---TYRWMAPEMIKRKP 2428 + +HRD+ N+L E+FE+KI DFG+A +WMAPE + + Sbjct: 775 KKCIHRDLAARNVLVTEDFEMKICDFGLARDIHYIDFYRKTTDGRLPVKWMAPEALFDRM 834 Query: 2429 YNRKVDVYSFGLLLWEMVT-GRIPFENLSPVQVAYAVATDKLKPMDPQDYCPAAVRPLIE 2605 + + DV+SFG+LLWE++T G P+ ++ PV+ + + PQ+ + ++ Sbjct: 835 FTTQSDVWSFGILLWEIMTLGGTPYPSV-PVEQMFDYLRSGKRLEKPQN-TSLEIYHILC 892 Query: 2606 QCCALQPEKRPDFWQLVKTLEKIQSVMSQGGSLD 2707 +C P +RP F +LV+ L++I SV S LD Sbjct: 893 ECWRTSPGQRPTFCELVEDLDRIISVSSNQDYLD 926
>P21803:FGFR2_MOUSE Fibroblast growth factor receptor 2 precursor - Mus musculus (Mouse)| Length = 821 Score = 109 bits (272), Expect = 8e-23 Identities = 88/309 (28%), Positives = 146/309 (47%), Gaps = 30/309 (9%) Frame = +2 Query: 1871 WKLDKAKLLVGHSFASGAHSRLYR----GLYDDKP-----VAIKFIRRPHEDPGGIMAAK 2023 W+ + KL +G G ++ G+ DKP VA+K ++ + K Sbjct: 474 WEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATE-------K 526 Query: 2024 LDKQYNTEINALSHL-YHKNVIKLV-ATHKCGPVYYIITELLPGGSLRSYLHN------- 2176 +E+ + + HKN+I L+ A + GP+Y +I E G+LR YL Sbjct: 527 DLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLY-VIVEYASKGNLREYLRARRPPGME 585 Query: 2177 --------PEHRPLPLERTISIALEIARGLEYVHSQGVVHRDIKPENILFDENFEVKIAD 2332 PE + + + +S ++ARG+EY+ SQ +HRD+ N+L EN +KIAD Sbjct: 586 YSYDINRVPEEQ-MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIAD 644 Query: 2333 FGIAXXXXXXXXXXXXXG---TYRWMAPEMIKRKPYNRKVDVYSFGLLLWEMVT-GRIPF 2500 FG+A +WMAPE + + Y + DV+SFG+L+WE+ T G P+ Sbjct: 645 FGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPY 704 Query: 2501 ENLSPVQVAYAVATDKLKPMDPQDYCPAAVRPLIEQCCALQPEKRPDFWQLVKTLEKIQS 2680 + PV+ + + + + MD C + ++ C P +RP F QLV+ L++I + Sbjct: 705 PGI-PVEELFKLLKEGHR-MDKPTNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILT 762 Query: 2681 VMSQGGSLD 2707 + + LD Sbjct: 763 LTTNEEYLD 771
>Q05397:FAK1_HUMAN Focal adhesion kinase 1 - Homo sapiens (Human)| Length = 1052 Score = 109 bits (272), Expect = 8e-23 Identities = 80/280 (28%), Positives = 132/280 (47%), Gaps = 8/280 (2%) Frame = +2 Query: 1859 STVDWKLDKAKLLVGHSFASGAHSRLYRGLY--DDKP---VAIKFIRRPHEDPGGIMAAK 2023 ST D+++ + ++ +G G +++G+Y + P VAIK + D Sbjct: 411 STRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSD-------S 463 Query: 2024 LDKQYNTEINALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLE 2203 + +++ E + H +++KL+ PV+ II EL G LRS+L ++ L L Sbjct: 464 VREKFLQEALTMRQFDHPHIVKLIGVITENPVW-IIMELCTLGELRSFLQVRKYS-LDLA 521 Query: 2204 RTISIALEIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIAXXXXXXXXXXXXX 2383 I A +++ L Y+ S+ VHRDI N+L N VK+ DFG++ Sbjct: 522 SLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASK 581 Query: 2384 G--TYRWMAPEMIKRKPYNRKVDVYSFGLLLWE-MVTGRIPFENLSPVQVAYAVATDKLK 2554 G +WMAPE I + + DV+ FG+ +WE ++ G PF+ + V + + Sbjct: 582 GKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERL 641 Query: 2555 PMDPQDYCPAAVRPLIEQCCALQPEKRPDFWQLVKTLEKI 2674 PM P CP + L+ +C A P +RP F +L L I Sbjct: 642 PMPPN--CPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTI 679
>P10936:YES_XENLA Tyrosine-protein kinase Yes - Xenopus laevis (African clawed frog)| Length = 537 Score = 108 bits (271), Expect = 1e-22 Identities = 86/313 (27%), Positives = 143/313 (45%), Gaps = 4/313 (1%) Frame = +2 Query: 1742 SSQKDSSWTRRYFDNVGRRRVSAVENVRSRTVSMAQAVQSTVDWKLDKAKLLVGHSFASG 1921 S QK + D + R + +V+ +T +A+ W++ + L + G Sbjct: 226 SLQKLVKHYSEHADGLCYRLTTVCPSVKPQTQGLAKDA-----WEIPRESLRLDVKLGQG 280 Query: 1922 AHSRLYRGLYDDKP-VAIKFIRRPHEDPGGIMAAKLDKQYNTEINALSHLYHKNVIKLVA 2098 ++ G ++ VAIK ++ PG +M + + E + L H ++ L A Sbjct: 281 CFGEVWIGTWNGTTKVAIKTLK-----PGTMMP----EAFLQEAQIMKKLRHDKLVPLYA 331 Query: 2099 THKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIALEIARGLEYVHSQGVVHRD 2278 P+Y I+TE + GSL +L + L L + + +A +IA G+ Y+ +HRD Sbjct: 332 VVSEEPIY-IVTEYMIKGSLLDFLKEGNGKYLKLPQLVDMAAQIADGMAYIERMNYIHRD 390 Query: 2279 IKPENILFDENFEVKIADFGIAXXXXXXXXXXXXXGTY--RWMAPEMIKRKPYNRKVDVY 2452 ++ NIL +N KIADFG+A + +W APE + K DV+ Sbjct: 391 LRAANILVGDNLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVW 450 Query: 2453 SFGLLLWEMVT-GRIPFENLSPVQVAYAVATDKLKPMDPQDYCPAAVRPLIEQCCALQPE 2629 SFG+LL E+V GR+P+ + +V V P PQ CP ++ L++ C P+ Sbjct: 451 SFGILLTELVAKGRVPYPGMVNREVLEQVERGYRMPC-PQ-RCPESLHELMKLCWKKDPD 508 Query: 2630 KRPDFWQLVKTLE 2668 +RP F + LE Sbjct: 509 ERPTFEYIQSFLE 521
>Q28923:YES_CANFA Proto-oncogene tyrosine-protein kinase Yes - Canis familiaris (Dog)| Length = 539 Score = 108 bits (271), Expect = 1e-22 Identities = 81/311 (26%), Positives = 139/311 (44%), Gaps = 4/311 (1%) Frame = +2 Query: 1748 QKDSSWTRRYFDNVGRRRVSAVENVRSRTVSMAQAVQSTVDWKLDKAKLLVGHSFASGAH 1927 QK + + D + + + V+ +T +A+ W++ + L + G Sbjct: 230 QKLVKHSTEHADGLCHKLTTVCPTVKPQTQGLAKDA-----WEIPRESLRLEVKLGQGCF 284 Query: 1928 SRLYRGLYDDKP-VAIKFIRRPHEDPGGIMAAKLDKQYNTEINALSHLYHKNVIKLVATH 2104 ++ G ++ VAIK ++ + + + + E + L H ++ L A Sbjct: 285 GEVWMGTWNGTTKVAIKTLK---------LGTMMPEAFLQEAQIMKKLRHDKLVPLYAVV 335 Query: 2105 KCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIALEIARGLEYVHSQGVVHRDIK 2284 P+Y I+TE + GSL +L + + L L + + +A +IA G+ Y+ +HRD++ Sbjct: 336 SEEPIY-IVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLR 394 Query: 2285 PENILFDENFEVKIADFGIAXXXXXXXXXXXXXGTY--RWMAPEMIKRKPYNRKVDVYSF 2458 NIL EN KIADFG+A + +W APE + K DV+SF Sbjct: 395 AANILVGENLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSF 454 Query: 2459 GLLLWEMVT-GRIPFENLSPVQVAYAVATDKLKPMDPQDYCPAAVRPLIEQCCALQPEKR 2635 G+L E+ T GR+P+ + +V V P PQ CP ++ L+ C P++R Sbjct: 455 GILQTELTTKGRVPYPGMVNREVLEQVERGYRMPC-PQG-CPESLHELMNLCWKKDPDER 512 Query: 2636 PDFWQLVKTLE 2668 P F + LE Sbjct: 513 PTFEYIQSFLE 523
>Q9Y6E0:STK24_HUMAN Serine/threonine-protein kinase 24 - Homo sapiens (Human)| Length = 443 Score = 108 bits (271), Expect = 1e-22 Identities = 79/250 (31%), Positives = 118/250 (47%), Gaps = 3/250 (1%) Frame = +2 Query: 1919 GAHSRLYRGLYD--DKPVAIKFIRRPHEDPGGIMAAKLDKQYNTEINALSHLYHKNVIKL 2092 G+ +++G+ + K VAIK I A + EI LS V K Sbjct: 45 GSFGEVFKGIDNRTQKVVAIKIIDLEE-------AEDEIEDIQQEITVLSQCDSPYVTKY 97 Query: 2093 VATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIALEIARGLEYVHSQGVVH 2272 ++ +II E L GGS L E PL + +I EI +GL+Y+HS+ +H Sbjct: 98 YGSYLKDTKLWIIMEYLGGGSALDLL---EPGPLDETQIATILREILKGLDYLHSEKKIH 154 Query: 2273 RDIKPENILFDENFEVKIADFGIA-XXXXXXXXXXXXXGTYRWMAPEMIKRKPYNRKVDV 2449 RDIK N+L E+ EVK+ADFG+A GT WMAPE+IK+ Y+ K D+ Sbjct: 155 RDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKADI 214 Query: 2450 YSFGLLLWEMVTGRIPFENLSPVQVAYAVATDKLKPMDPQDYCPAAVRPLIEQCCALQPE 2629 +S G+ E+ G P L P++V + + K P + ++ +E C +P Sbjct: 215 WSLGITAIELARGEPPHSELHPMKVLFLI--PKNNPPTLEGNYSKPLKEFVEACLNKEPS 272 Query: 2630 KRPDFWQLVK 2659 RP +L+K Sbjct: 273 FRPTAKELLK 282
>Q09YK0:MET_MUNMU Hepatocyte growth factor receptor precursor - Muntiacus muntjak| (Barking deer) (Indian muntjac) Length = 1382 Score = 108 bits (271), Expect = 1e-22 Identities = 87/298 (29%), Positives = 146/298 (48%), Gaps = 18/298 (6%) Frame = +2 Query: 1841 MAQAVQSTVDWKLDKAKLLVGHS--FASGAHSRLYRGLY---DDKPV--AIKFIRRPHED 1999 + QAVQ V + + L+V + G +Y G DDK + A+K + R D Sbjct: 1063 LVQAVQHVV---IGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDDKKIHCAVKSLNRI-TD 1118 Query: 2000 PGGIMAAKLDKQYNTEINALSHLYHKNVIKLVAT---HKCGPVYYIITELLPGGSLRSYL 2170 G + Q+ TE + H NV+ L+ + P+ ++ + G LR+++ Sbjct: 1119 IGEV------SQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPL--VVLPYMKHGDLRNFI 1170 Query: 2171 HNPEHRPLPLERTISIALEIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIAXX 2350 N H P ++ I L++A+G+EY+ S+ VHRD+ N + DE F VK+ADFG+A Sbjct: 1171 RNETHNPT-VKDLIGFGLQVAKGMEYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARD 1229 Query: 2351 XXXXXXXXXXXGT-----YRWMAPEMIKRKPYNRKVDVYSFGLLLWEMVT-GRIPFENLS 2512 T +WMA E ++ + + K DV+SFG+LLWE++T G P+ +++ Sbjct: 1230 VYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVN 1289 Query: 2513 PVQVAYAVATDK--LKPMDPQDYCPAAVRPLIEQCCALQPEKRPDFWQLVKTLEKIQS 2680 + + + L+P +YCP A+ ++ +C + E RP F +LV + I S Sbjct: 1290 TFDITVYLLQGRRLLQP----EYCPDALYEVMLKCWHPKAELRPSFSELVSRISAIFS 1343
>P21802:FGFR2_HUMAN Fibroblast growth factor receptor 2 precursor - Homo sapiens (Human)| Length = 821 Score = 108 bits (271), Expect = 1e-22 Identities = 88/309 (28%), Positives = 146/309 (47%), Gaps = 30/309 (9%) Frame = +2 Query: 1871 WKLDKAKLLVGHSFASGAHSRLYR----GLYDDKP-----VAIKFIRRPHEDPGGIMAAK 2023 W+ + KL +G G ++ G+ DKP VA+K ++ + K Sbjct: 474 WEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATE-------K 526 Query: 2024 LDKQYNTEINALSHL-YHKNVIKLV-ATHKCGPVYYIITELLPGGSLRSYLHN------- 2176 +E+ + + HKN+I L+ A + GP+Y +I E G+LR YL Sbjct: 527 DLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLY-VIVEYASKGNLREYLRARRPPGME 585 Query: 2177 --------PEHRPLPLERTISIALEIARGLEYVHSQGVVHRDIKPENILFDENFEVKIAD 2332 PE + + + +S ++ARG+EY+ SQ +HRD+ N+L EN +KIAD Sbjct: 586 YSYDINRVPEEQ-MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIAD 644 Query: 2333 FGIAXXXXXXXXXXXXXG---TYRWMAPEMIKRKPYNRKVDVYSFGLLLWEMVT-GRIPF 2500 FG+A +WMAPE + + Y + DV+SFG+L+WE+ T G P+ Sbjct: 645 FGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPY 704 Query: 2501 ENLSPVQVAYAVATDKLKPMDPQDYCPAAVRPLIEQCCALQPEKRPDFWQLVKTLEKIQS 2680 + PV+ + + + + MD C + ++ C P +RP F QLV+ L++I + Sbjct: 705 PGI-PVEELFKLLKEGHR-MDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILT 762 Query: 2681 VMSQGGSLD 2707 + + LD Sbjct: 763 LTTNEEYLD 771
>O35346:FAK1_RAT Focal adhesion kinase 1 - Rattus norvegicus (Rat)| Length = 1055 Score = 108 bits (271), Expect = 1e-22 Identities = 80/280 (28%), Positives = 132/280 (47%), Gaps = 8/280 (2%) Frame = +2 Query: 1859 STVDWKLDKAKLLVGHSFASGAHSRLYRGLY--DDKP---VAIKFIRRPHEDPGGIMAAK 2023 ST D+++ + ++ +G G +++G+Y + P VAIK + D Sbjct: 411 STRDYEIQRERIELGRCIGEGQFGDVHQGVYLSPENPALAVAIKTCKNCTSD-------S 463 Query: 2024 LDKQYNTEINALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLE 2203 + +++ E + H +++KL+ PV+ II EL G LRS+L ++ L L Sbjct: 464 VREKFLQEALTMRQFDHPHIVKLIGVITENPVW-IIMELCTLGELRSFLQVRKYS-LDLA 521 Query: 2204 RTISIALEIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIAXXXXXXXXXXXXX 2383 I A +++ L Y+ S+ VHRDI N+L N VK+ DFG++ Sbjct: 522 SLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASK 581 Query: 2384 G--TYRWMAPEMIKRKPYNRKVDVYSFGLLLWE-MVTGRIPFENLSPVQVAYAVATDKLK 2554 G +WMAPE I + + DV+ FG+ +WE ++ G PF+ + V + + Sbjct: 582 GKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERL 641 Query: 2555 PMDPQDYCPAAVRPLIEQCCALQPEKRPDFWQLVKTLEKI 2674 PM P CP + L+ +C A P +RP F +L L I Sbjct: 642 PMPPN--CPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTI 679
>Q924U5:TESK2_RAT Dual specificity testis-specific protein kinase 2 - Rattus norvegicus| (Rat) Length = 570 Score = 108 bits (270), Expect = 1e-22 Identities = 72/246 (29%), Positives = 121/246 (49%), Gaps = 12/246 (4%) Frame = +2 Query: 1991 HEDPGGIMAAKLDKQYNTEINAL------SHLYHKNVIKLVATHKCGPVYYIITELLPGG 2152 H G +MA K++ + N L + L H N+++ + + +TE + G Sbjct: 77 HRASGQVMALKMNTLSSNRANLLKEMQLMNRLSHPNILRFMGVCVHQGQLHALTEYINSG 136 Query: 2153 SLRSYLHNPEHRPLPLERTISIALEIARGLEYVHSQGVVHRDIKPENILF--DEN-FEVK 2323 +L L + + LP + +A +IA GL Y+H +G+ HRD+ +N L DEN + Sbjct: 137 NLEQLLDSNLY--LPWTVRVKLAYDIAVGLSYLHFKGIFHRDLTSKNCLIKRDENGYSAV 194 Query: 2324 IADFGIAXXXXXXXXXXXXX---GTYRWMAPEMIKRKPYNRKVDVYSFGLLLWEMVTGRI 2494 +ADFG+A G+ WMAPE+++ +PYN K DV+S+G++L E++ Sbjct: 195 VADFGLAEKIPDASIGSEKLAVVGSPFWMAPEVLRDEPYNEKADVFSYGIILCEIIARIQ 254 Query: 2495 PFENLSPVQVAYAVATDKLKPMDPQDYCPAAVRPLIEQCCALQPEKRPDFWQLVKTLEKI 2674 + P + + D + M CP+ L CC + P+ RP F ++ KTLE+I Sbjct: 255 ADPDYLPRTENFGLDYDAFQHMVGD--CPSDFLQLTFNCCNMDPKLRPSFEEIGKTLEEI 312 Query: 2675 QSVMSQ 2692 S + + Sbjct: 313 MSRLQE 318
>Q4P5N0:STE20_USTMA Serine/threonine-protein kinase SMU1 - Ustilago maydis (Smut fungus)| Length = 746 Score = 108 bits (270), Expect = 1e-22 Identities = 96/419 (22%), Positives = 172/419 (41%), Gaps = 3/419 (0%) Frame = +2 Query: 1394 PAKSEKSKAPRARSLVKSPSSMMLLSYLNKAYPNQGSSVQNADGSLHKPRSKSPLPSVVP 1573 P EK + A + P+ + P +S +AD +L RS +P P P Sbjct: 338 PVLYEKPRTAPAPPGITHPNRPSEFGSPDLRQPPSNASTSSADTALRPSRS-TPAPGAAP 396 Query: 1574 SDTFREARASSQRFTSPPPKRVGSDKSVYGKSLGREQCDMAASPDWCSTPVVFGEHSSQK 1753 + +S+ PPP + + +PD P S Sbjct: 397 PPNAKTTSSSN-----PPPCKPSP---------------ASRAPD---APAAVSAASKNA 433 Query: 1754 DSSWTRRYFDNVGRRRVSAVENVR-SRTVSMAQAVQSTVD-WKLDKAKLLVGHSFASGAH 1927 +V RRR + ++ S ++ QA+ + D KL ++ +G + G Sbjct: 434 KGP------GSVPRRRETKKSTIKDSEVIAKLQAICTDADPTKLYRSLQKIGQGASGGVF 487 Query: 1928 SRLYRGLYDDKPVAIKFIRRPHEDPGGIMAAKLDKQYNTEINALSHLYHKNVIKLVATHK 2107 + G + VAIK + + ++ EI + H+N++ + + Sbjct: 488 TAYQVGT--NVSVAIKQMNLEQQPKKDLII--------NEILVMKESRHRNIVNFIDSFL 537 Query: 2108 CGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIALEIARGLEYVHSQGVVHRDIKP 2287 +++ E + GGSL + + + +++ E+ GL ++H GV+HRDIK Sbjct: 538 FKGDLWVVMEYMEGGSLTDVV---TCNIMTEGQIAAVSREVLEGLRHLHQHGVIHRDIKS 594 Query: 2288 ENILFDENFEVKIADFGI-AXXXXXXXXXXXXXGTYRWMAPEMIKRKPYNRKVDVYSFGL 2464 +N+L ++K+ DFG A GT WMAPE++ RK Y KVD++S G+ Sbjct: 595 DNVLLSLQGDIKLTDFGFCAQIGESQAKRTTMVGTPYWMAPEVVTRKEYGPKVDIWSLGI 654 Query: 2465 LLWEMVTGRIPFENLSPVQVAYAVATDKLKPMDPQDYCPAAVRPLIEQCCALQPEKRPD 2641 + EMV G P+ N +P++ Y +AT+ ++ + + + + E+RPD Sbjct: 655 MCIEMVEGEPPYLNENPLRALYLIATNGTPKINNPENLSNTFKDFLTTSLDVDAERRPD 713
>O54785:LIMK2_MOUSE LIM domain kinase 2 - Mus musculus (Mouse)| Length = 638 Score = 108 bits (270), Expect = 1e-22 Identities = 73/271 (26%), Positives = 120/271 (44%), Gaps = 33/271 (12%) Frame = +2 Query: 1979 IRRPHEDPGGIMAAK--------LDKQYNTEINALSHLYHKNVIKLVATHKCGPVYYIIT 2134 I+ H+ G +M K K + TE+ + L H NV+K + ++T Sbjct: 346 IKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLT 405 Query: 2135 ELLPGGSLRSYLHNPEHRPLPLERTISIALEIARGLEYVHSQGVVHRDIKPENILFDENF 2314 E + GG+L+ +L + + P P ++ + A I+ G+ Y+HS ++HRD+ N L + Sbjct: 406 EYIEGGTLKDFLRSVD--PFPWQQKVRFAKGISSGMAYLHSMCIIHRDLNSHNCLIKLDK 463 Query: 2315 EVKIADFGIA---------------------XXXXXXXXXXXXXGTYRWMAPEMIKRKPY 2431 V +ADFG++ G WMAPEM+ K Y Sbjct: 464 TVVVADFGLSRLIVEERKRPPVEKATTKKRTLRKSDRKKRYTVVGNPYWMAPEMLNGKSY 523 Query: 2432 NRKVDVYSFGLLLWEMVTGRIPFENLSPVQVAYAVAT----DKLKPMDPQDYCPAAVRPL 2599 + VDV+SFG++L E++ + P + + + +K P D CP A PL Sbjct: 524 DETVDVFSFGIVLCEIIGQVYADPDCLPRTLDFGLNVKLFWEKFVPTD----CPPAFFPL 579 Query: 2600 IEQCCALQPEKRPDFWQLVKTLEKIQSVMSQ 2692 CC L+PE RP F +L + E + + + Sbjct: 580 AAICCKLEPESRPAFSKLEDSFEALSLFLGE 610
>P34265:KIN31_CAEEL Probable tyrosine-protein kinase kin-31 - Caenorhabditis elegans| Length = 437 Score = 108 bits (270), Expect = 1e-22 Identities = 76/275 (27%), Positives = 133/275 (48%), Gaps = 7/275 (2%) Frame = +2 Query: 1871 WKLDKAKLLVGHSFASGAHSRLYRGLYDDK------PVAIKFIRRPHEDPGGIMAAKLDK 2032 W+LD +++ GA + G+ K VA+K ++ GI ++ K Sbjct: 123 WELDHGNIVIEKKLGEGAFGEVSSGVMKFKRGGRLVKVAVKQVKTD-----GIGKDQI-K 176 Query: 2033 QYNTEINALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTI 2212 + E + +L H N+++ + +++ EL GG+L SYL + E LP+++ Sbjct: 177 DFLMEARTMRNLGHPNIVRFLGIAVLQEPLFLVMELATGGALDSYLKHNEL--LPIDKRH 234 Query: 2213 SIALEIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIAXXXXXXXXXXXXXGTY 2392 + L+ A GLEY+H + ++HRDI N L+ + +VKI+DFG+ Sbjct: 235 EMLLQAAWGLEYIHGKPMLHRDIAARNCLYGDG-KVKISDFGLTRRGTIYQLHPETKSPI 293 Query: 2393 RWMAPEMIKRKPYNRKVDVYSFGLLLWEMV-TGRIPFENLSPVQVAYAVATDKLKPMDPQ 2569 RW+A ++K DV+++G+L WE+ G P+ L+ +VA V TD + M P Sbjct: 294 RWLA-------VCSQKTDVWAYGILCWEIFNNGAEPYPGLTANEVAKQV-TDGYR-MPPH 344 Query: 2570 DYCPAAVRPLIEQCCALQPEKRPDFWQLVKTLEKI 2674 V+ L+ +CCA P RP + + L+++ Sbjct: 345 QLAAPEVQALMTRCCAENPNDRPTMSDVAQILQRV 379
>P06245:KAPB_YEAST cAMP-dependent protein kinase type 2 - Saccharomyces cerevisiae| (Baker's yeast) Length = 380 Score = 108 bits (270), Expect = 1e-22 Identities = 63/206 (30%), Positives = 109/206 (52%) Frame = +2 Query: 1934 LYRGLYDDKPVAIKFIRRPHEDPGGIMAAKLDKQYNTEINALSHLYHKNVIKLVATHKCG 2113 L R +++ + AIK +++ ++ K + N E L + H +I++ T + Sbjct: 86 LVRSVHNGRYYAIKVLKKQQ-----VVKMKQVEHTNDERRMLKLVEHPFLIRMWGTFQDA 140 Query: 2114 PVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIALEIARGLEYVHSQGVVHRDIKPEN 2293 +++ + + GG L S L + P P+ + A E+ LEY+H+ +++RD+KPEN Sbjct: 141 RNIFMVMDYIEGGELFSLLRKSQRFPNPVAKFY--AAEVILALEYLHAHNIIYRDLKPEN 198 Query: 2294 ILFDENFEVKIADFGIAXXXXXXXXXXXXXGTYRWMAPEMIKRKPYNRKVDVYSFGLLLW 2473 IL D N +KI DFG A GT ++APE+I KPYN+ VD +S G+L++ Sbjct: 199 ILLDRNGHIKITDFGFA--KEVQTVTWTLCGTPDYIAPEVITTKPYNKSVDWWSLGVLIY 256 Query: 2474 EMVTGRIPFENLSPVQVAYAVATDKL 2551 EM+ G PF + +P++ + K+ Sbjct: 257 EMLAGYTPFYDTTPMKTYEKILQGKV 282
>O42127:FGFR3_XENLA Fibroblast growth factor receptor 3 precursor - Xenopus laevis| (African clawed frog) Length = 802 Score = 108 bits (270), Expect = 1e-22 Identities = 89/310 (28%), Positives = 150/310 (48%), Gaps = 31/310 (10%) Frame = +2 Query: 1871 WKLDKAKLLVGHSFASGAHSRLYR----GLYDDKP-----VAIKFIRRPHEDPGGIMAAK 2023 W+L +++L +G G ++ G+ ++P VA+K ++ D K Sbjct: 455 WELLRSRLTLGKPLGEGCFGQVVMAEAIGIDKERPNKPATVAVKMLKDDATD-------K 507 Query: 2024 LDKQYNTEINALSHL-YHKNVIKLV-ATHKCGPVYYIITELLPGGSLRSYLHNPEHRP-- 2191 +E+ + + HKN+I L+ A + GP+Y ++ E GSLR YL RP Sbjct: 508 DLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLY-VLVEYASKGSLREYLK--ARRPPG 564 Query: 2192 ---------LPLERT-----ISIALEIARGLEYVHSQGVVHRDIKPENILFDENFEVKIA 2329 +P E+ +S A ++ARG+EY+ SQ +HRD+ N+L ++ +KIA Sbjct: 565 MDYSFDACKIPAEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTDDNVMKIA 624 Query: 2330 DFGIAXXXXXXXXXXXXXG---TYRWMAPEMIKRKPYNRKVDVYSFGLLLWEMVT-GRIP 2497 DFG+A +WMAPE + + Y DV+S+G+LLWE+ T G P Sbjct: 625 DFGLARDIHNIDYYKKTTNGRLPVKWMAPEALFDRIYTHHSDVWSYGVLLWEIFTLGGSP 684 Query: 2498 FENLSPVQVAYAVATDKLKPMDPQDYCPAAVRPLIEQCCALQPEKRPDFWQLVKTLEKIQ 2677 + + PV+ + + + + MD C + ++ +C P +RP F QLV+ L+++ Sbjct: 685 YPGI-PVEELFKLLKEGHR-MDKPANCTHELYMIMRECWHAVPSQRPAFKQLVEDLDRVL 742 Query: 2678 SVMSQGGSLD 2707 +V S LD Sbjct: 743 TVTSTNEYLD 752
>O75385:ULK1_HUMAN Serine/threonine-protein kinase ULK1 - Homo sapiens (Human)| Length = 1050 Score = 108 bits (269), Expect = 2e-22 Identities = 83/266 (31%), Positives = 130/266 (48%), Gaps = 14/266 (5%) Frame = +2 Query: 1889 KLLVGHSFASGAHSRLYRGLYDDK---PVAIKFIRRPHEDPGGIMAAKLDKQYNTEINAL 2059 K L+GH GA + +++G + +K VA+K I + + AK EI L Sbjct: 19 KDLIGH----GAFAVVFKGRHREKHDLEVAVKCINKKN-------LAKSQTLLGKEIKIL 67 Query: 2060 SHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIALE-IAR 2236 L H+N++ L + Y++ E GG L YLH R L E TI + L+ IA Sbjct: 68 KELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLH--AMRTLS-EDTIRLFLQQIAG 124 Query: 2237 GLEYVHSQGVVHRDIKPENILFDE---------NFEVKIADFGIAXXXXXXXXXXXXXGT 2389 + +HS+G++HRD+KP+NIL + VKIADFG A G+ Sbjct: 125 AMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGS 184 Query: 2390 YRWMAPEMIKRKPYNRKVDVYSFGLLLWEMVTGRIPFENLSPVQVAYAVATDK-LKPMDP 2566 +MAPE+I + Y+ K D++S G ++++ +TG+ PF+ SP + +K L P P Sbjct: 185 PMYMAPEVIMSQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLVPTIP 244 Query: 2567 QDYCPAAVRPLIEQCCALQPEKRPDF 2644 ++ A +R L+ + R DF Sbjct: 245 RE-TSAPLRQLLLALLQRNHKDRMDF 269
>O00506:STK25_HUMAN Serine/threonine-protein kinase 25 - Homo sapiens (Human)| Length = 426 Score = 108 bits (269), Expect = 2e-22 Identities = 78/252 (30%), Positives = 120/252 (47%), Gaps = 5/252 (1%) Frame = +2 Query: 1919 GAHSRLYRGL--YDDKPVAIKFIRRPHEDPGGIMAAKLDKQYNTEINALSHLYHKNVIKL 2092 G+ +Y+G+ + + VAIK I A + EI LS + + Sbjct: 29 GSFGEVYKGIDNHTKEVVAIKIIDLEE-------AEDEIEDIQQEITVLSQCDSPYITRY 81 Query: 2093 VATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTI--SIALEIARGLEYVHSQGV 2266 ++ +II E L GGS L +P PLE T +I EI +GL+Y+HS+ Sbjct: 82 FGSYLKSTKLWIIMEYLGGGSALDLL-----KPGPLEETYIATILREILKGLDYLHSERK 136 Query: 2267 VHRDIKPENILFDENFEVKIADFGIA-XXXXXXXXXXXXXGTYRWMAPEMIKRKPYNRKV 2443 +HRDIK N+L E +VK+ADFG+A GT WMAPE+IK+ Y+ K Sbjct: 137 IHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDFKA 196 Query: 2444 DVYSFGLLLWEMVTGRIPFENLSPVQVAYAVATDKLKPMDPQDYCPAAVRPLIEQCCALQ 2623 D++S G+ E+ G P +L P++V + + + ++ Q P + +E C Sbjct: 197 DIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNSPPTLEGQHSKP--FKEFVEACLNKD 254 Query: 2624 PEKRPDFWQLVK 2659 P RP +L+K Sbjct: 255 PRFRPTAKELLK 266
>Q99KH8:STK24_MOUSE Serine/threonine-protein kinase 24 - Mus musculus (Mouse)| Length = 431 Score = 108 bits (269), Expect = 2e-22 Identities = 79/250 (31%), Positives = 118/250 (47%), Gaps = 3/250 (1%) Frame = +2 Query: 1919 GAHSRLYRGLYD--DKPVAIKFIRRPHEDPGGIMAAKLDKQYNTEINALSHLYHKNVIKL 2092 G+ +++G+ + K VAIK I A + EI LS V K Sbjct: 33 GSFGEVFKGIDNRTQKVVAIKIIDLEE-------AEDEIEDIQQEITVLSQCDSPYVTKY 85 Query: 2093 VATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIALEIARGLEYVHSQGVVH 2272 ++ +II E L GGS L E PL + +I EI +GL+Y+HS+ +H Sbjct: 86 YGSYLKDTKLWIIMEYLGGGSALDLL---EPGPLDEIQIATILREILKGLDYLHSEKKIH 142 Query: 2273 RDIKPENILFDENFEVKIADFGIA-XXXXXXXXXXXXXGTYRWMAPEMIKRKPYNRKVDV 2449 RDIK N+L E+ EVK+ADFG+A GT WMAPE+IK+ Y+ K D+ Sbjct: 143 RDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKADI 202 Query: 2450 YSFGLLLWEMVTGRIPFENLSPVQVAYAVATDKLKPMDPQDYCPAAVRPLIEQCCALQPE 2629 +S G+ E+ G P L P++V + + K P + ++ +E C +P Sbjct: 203 WSLGITAIELAKGEPPHSELHPMKVLFLI--PKNNPPTLEGNYSKPLKEFVEACLNKEPS 260 Query: 2630 KRPDFWQLVK 2659 RP +L+K Sbjct: 261 FRPTAKELLK 270
>Q61036:PAK3_MOUSE Serine/threonine-protein kinase PAK 3 - Mus musculus (Mouse)| Length = 559 Score = 108 bits (269), Expect = 2e-22 Identities = 105/432 (24%), Positives = 189/432 (43%), Gaps = 12/432 (2%) Frame = +2 Query: 1400 KSEKSKAPRA-RSLVKSPSSMMLLSYLNKAYPNQGSSVQNADGSLHKPRSKSPLPSVVP- 1573 K E+ K P+A ++K S ++ N+ Y + S ++A G + +S + S P Sbjct: 124 KLEQKKNPQAVLDVLKFYDSKETVN--NQKYMSFTSGDKSAHGYIAAHQSNTKTASEPPL 181 Query: 1574 ----SDTFREARASSQRFTSPPP---KRVGSDKSVYGKSLGREQCDMAASPDWCSTPVVF 1732 S+ E + PPP R KS+Y +S+ E A+P+ P Sbjct: 182 APPVSEEEDEEEEEEEDDNEPPPVIAPRPEHTKSIYTRSVV-ESIASPAAPNKEDIP--- 237 Query: 1733 GEHSSQKDSSWTRRYFDNVGRRRVSAVENVRSRTVSMAQAVQSTVDWKLDKAKLLVGHSF 1912 S ++++ T Y + +R+ S + + + + ++S V K K Sbjct: 238 ---PSAENANSTTLYRNTDRQRKKSKMTDEE-----ILEKLRSIVSVGDPKKKYTRFEKI 289 Query: 1913 ASGAHSRLYRGL--YDDKPVAIKFIRRPHEDPGGIMAAKLDKQYNTEINALSHLYHKNVI 2086 GA +Y L + VAIK + + ++ EI + + N++ Sbjct: 290 GQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELII--------NEILVMRENKNPNIV 341 Query: 2087 KLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIALEIARGLEYVHSQGV 2266 + ++ G +++ E L GGSL + + + ++ E + L+++HS V Sbjct: 342 NYLDSYLVGDELWVVMEYLAGGSLTDVV---TETCMDEGQIAAVCRECLQALDFLHSNQV 398 Query: 2267 VHRDIKPENILFDENFEVKIADFGI-AXXXXXXXXXXXXXGTYRWMAPEMIKRKPYNRKV 2443 +HRDIK +NIL + VK+ DFG A GT WMAPE++ RK Y KV Sbjct: 399 IHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKV 458 Query: 2444 DVYSFGLLLWEMVTGRIPFENLSPVQVAYAVATDKLKPMDPQDYCPAAVRPLIEQCCALQ 2623 D++S G++ EMV G P+ N +P++ Y +AT+ + + A R + +C + Sbjct: 459 DIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMD 518 Query: 2624 PEKRPDFWQLVK 2659 ++R +L++ Sbjct: 519 VDRRGSAKELLQ 530
>Q64303:PAK2_RAT Serine/threonine-protein kinase PAK 2 - Rattus norvegicus (Rat)| Length = 524 Score = 108 bits (269), Expect = 2e-22 Identities = 60/206 (29%), Positives = 103/206 (50%), Gaps = 1/206 (0%) Frame = +2 Query: 2045 EINALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIAL 2224 EI + L + N++ + ++ G +++ E L GGSL + + + ++ Sbjct: 294 EILVMKELKNPNIVNFLDSYLVGDELFVVMEYLAGGSLTDVV---TETCMDEAQIAAVCR 350 Query: 2225 EIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGI-AXXXXXXXXXXXXXGTYRWM 2401 E + LE++H+ V+HRDIK +N+L VK+ DFG A GT WM Sbjct: 351 ECLQALEFLHANQVIHRDIKSDNVLLGMEGSVKLTDFGFCAQITPEQSKRSTMVGTPYWM 410 Query: 2402 APEMIKRKPYNRKVDVYSFGLLLWEMVTGRIPFENLSPVQVAYAVATDKLKPMDPQDYCP 2581 APE++ RK Y KVD++S G++ EMV G P+ N +P++ Y +AT+ + + Sbjct: 411 APEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPEKLS 470 Query: 2582 AAVRPLIEQCCALQPEKRPDFWQLVK 2659 R + +C + EKR +L++ Sbjct: 471 PIFRDFLNRCLEMDVEKRGSAKELLQ 496
>Q29502:PAK2_RABIT Serine/threonine-protein kinase PAK 2 - Oryctolagus cuniculus| (Rabbit) Length = 524 Score = 108 bits (269), Expect = 2e-22 Identities = 60/206 (29%), Positives = 103/206 (50%), Gaps = 1/206 (0%) Frame = +2 Query: 2045 EINALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIAL 2224 EI + L + N++ + ++ G +++ E L GGSL + + + ++ Sbjct: 294 EILVMKELKNPNIVNFLDSYLVGDELFVVMEYLAGGSLTDVV---TETCMDEAQIAAVCR 350 Query: 2225 EIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGI-AXXXXXXXXXXXXXGTYRWM 2401 E + LE++H+ V+HRDIK +N+L VK+ DFG A GT WM Sbjct: 351 ECLQALEFLHANQVIHRDIKSDNVLLGMEGSVKLTDFGFCAQITPEQSKRSTMVGTPYWM 410 Query: 2402 APEMIKRKPYNRKVDVYSFGLLLWEMVTGRIPFENLSPVQVAYAVATDKLKPMDPQDYCP 2581 APE++ RK Y KVD++S G++ EMV G P+ N +P++ Y +AT+ + + Sbjct: 411 APEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPEKLS 470 Query: 2582 AAVRPLIEQCCALQPEKRPDFWQLVK 2659 R + +C + EKR +L++ Sbjct: 471 PIFRDFLNRCLEMDVEKRGSAKELLQ 496
>Q8CIN4:PAK2_MOUSE Serine/threonine-protein kinase PAK 2 - Mus musculus (Mouse)| Length = 524 Score = 108 bits (269), Expect = 2e-22 Identities = 60/206 (29%), Positives = 103/206 (50%), Gaps = 1/206 (0%) Frame = +2 Query: 2045 EINALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIAL 2224 EI + L + N++ + ++ G +++ E L GGSL + + + ++ Sbjct: 294 EILVMKELKNPNIVNFLDSYLVGDELFVVMEYLAGGSLTDVV---TETCMDEAQIAAVCR 350 Query: 2225 EIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGI-AXXXXXXXXXXXXXGTYRWM 2401 E + LE++H+ V+HRDIK +N+L VK+ DFG A GT WM Sbjct: 351 ECLQALEFLHANQVIHRDIKSDNVLLGMEGSVKLTDFGFCAQITPEQSKRSTMVGTPYWM 410 Query: 2402 APEMIKRKPYNRKVDVYSFGLLLWEMVTGRIPFENLSPVQVAYAVATDKLKPMDPQDYCP 2581 APE++ RK Y KVD++S G++ EMV G P+ N +P++ Y +AT+ + + Sbjct: 411 APEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPEKLS 470 Query: 2582 AAVRPLIEQCCALQPEKRPDFWQLVK 2659 R + +C + EKR +L++ Sbjct: 471 PIFRDFLNRCLEMDVEKRGSAKELLQ 496
>Q13177:PAK2_HUMAN Serine/threonine-protein kinase PAK 2 - Homo sapiens (Human)| Length = 524 Score = 108 bits (269), Expect = 2e-22 Identities = 60/206 (29%), Positives = 103/206 (50%), Gaps = 1/206 (0%) Frame = +2 Query: 2045 EINALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIAL 2224 EI + L + N++ + ++ G +++ E L GGSL + + + ++ Sbjct: 294 EILVMKELKNPNIVNFLDSYLVGDELFVVMEYLAGGSLTDVV---TETCMDEAQIAAVCR 350 Query: 2225 EIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGI-AXXXXXXXXXXXXXGTYRWM 2401 E + LE++H+ V+HRDIK +N+L VK+ DFG A GT WM Sbjct: 351 ECLQALEFLHANQVIHRDIKSDNVLLGMEGSVKLTDFGFCAQITPEQSKRSTMVGTPYWM 410 Query: 2402 APEMIKRKPYNRKVDVYSFGLLLWEMVTGRIPFENLSPVQVAYAVATDKLKPMDPQDYCP 2581 APE++ RK Y KVD++S G++ EMV G P+ N +P++ Y +AT+ + + Sbjct: 411 APEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPEKLS 470 Query: 2582 AAVRPLIEQCCALQPEKRPDFWQLVK 2659 R + +C + EKR +L++ Sbjct: 471 PIFRDFLNRCLEMDVEKRGSAKELLQ 496
>Q25410:MIPR_LYMST Putative molluscan insulin-related peptide(s) receptor precursor -| Lymnaea stagnalis (Great pond snail) Length = 1607 Score = 108 bits (269), Expect = 2e-22 Identities = 83/306 (27%), Positives = 141/306 (46%), Gaps = 29/306 (9%) Frame = +2 Query: 1868 DWKLDKAKLLVGHSFASGAHSRLY----RGLYDDK----PVAIKFI--RRPHEDPGGIMA 2017 +W++D+ K+ + G+ +Y +G+ DD PVA+K + R D Sbjct: 1029 EWEVDRDKIKLIKELGQGSFGMVYEGVAKGIRDDPNEEIPVAVKTVNDRASFSDR----- 1083 Query: 2018 AKLDKQYNTEINALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYL--HNPEH-- 2185 +++ E + + +V+KL+ G +I EL+ G L++YL H P+ Sbjct: 1084 ----REFLKEATTMKEFHCHHVVKLLGVVSTGQPALVIMELMALGDLKNYLRGHRPDEDH 1139 Query: 2186 ---RPLPLERTISIALEIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIAXXXX 2356 P L + +A EIA G+ Y+ + VHRD+ N + E VKI DFG+ Sbjct: 1140 PGVMPPHLLDILQMAGEIADGMAYLADKKFVHRDLAARNCMVSEERTVKIGDFGMTRDIY 1199 Query: 2357 XXXXXXXXXG---TYRWMAPEMIKRKPYNRKVDVYSFGLLLWEMVT-GRIPFENLSPVQV 2524 RWMAPE +K + DV+S+G+++WEMVT P++ LS +V Sbjct: 1200 ETDYYRKGGKGMLPVRWMAPESLKDGVFTSLSDVWSYGVVMWEMVTLAAQPYQGLSNEEV 1259 Query: 2525 AYAVATDKLKPMDPQDYCPAAVRPLIEQCCALQPEKRPDFWQLVKTL--------EKIQS 2680 ++ + M+ + CP + L++ C A +P +RP F +++ L EK+ Sbjct: 1260 VKFISDGYI--MELPENCPNEMAYLMQHCWAKKPNQRPTFKAIIEYLLPKLKPSFEKVSY 1317 Query: 2681 VMSQGG 2698 + GG Sbjct: 1318 FFTSGG 1323
>O73798:IGF1R_XENLA Insulin-like growth factor 1 receptor precursor - Xenopus laevis| (African clawed frog) Length = 1358 Score = 108 bits (269), Expect = 2e-22 Identities = 76/287 (26%), Positives = 133/287 (46%), Gaps = 21/287 (7%) Frame = +2 Query: 1871 WKLDKAKLLVGHSFASGAHSRLYRGLYD-------DKPVAIKFIRRPHEDPGGIMAAKLD 2029 W++ + K+ + G+ +Y G+ + VAIK + AA + Sbjct: 988 WEVPREKITMNRELGQGSFGMVYEGIAKGVVKDEAETKVAIKTVNE---------AASMR 1038 Query: 2030 K--QYNTEINALSHLYHKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHN-------PE 2182 + ++ E + + +V++L+ G +I EL+ G L+SYL + Sbjct: 1039 ERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPDTESNS 1098 Query: 2183 HRPLP-LERTISIALEIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGIAXXXXX 2359 +P P L++ I +A EIA G+ Y+++ VHRD+ N + E+F VKI DFG+ Sbjct: 1099 GQPTPSLKKMIQMAGEIADGMSYLNANKFVHRDLAARNCMVTEDFTVKIGDFGMTRDIYE 1158 Query: 2360 XXXXXXXXG---TYRWMAPEMIKRKPYNRKVDVYSFGLLLWEMVT-GRIPFENLSPVQVA 2527 RWM+PE +K + DV+SFG++LWE+ T P++ +S QV Sbjct: 1159 TDYYRKGGKGLLPVRWMSPESLKDGVFTTNSDVWSFGVVLWEIATLAEQPYQGMSNEQVL 1218 Query: 2528 YAVATDKLKPMDPQDYCPAAVRPLIEQCCALQPEKRPDFWQLVKTLE 2668 V L ++ D CP + L+ C P+ RP F +++ +++ Sbjct: 1219 RFVMEGGL--LEKPDNCPDMLFELMRMCWQFNPKMRPSFLEIISSIK 1263
>P18461:FGFR2_CHICK Fibroblast growth factor receptor 2 precursor - Gallus gallus| (Chicken) Length = 823 Score = 108 bits (269), Expect = 2e-22 Identities = 87/309 (28%), Positives = 146/309 (47%), Gaps = 30/309 (9%) Frame = +2 Query: 1871 WKLDKAKLLVGHSFASGAHSRLYR----GLYDDKP-----VAIKFIRRPHEDPGGIMAAK 2023 W+ + KL +G G ++ G+ D+P VA+K ++ + K Sbjct: 476 WEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDRPKEAVTVAVKMLKDDATE-------K 528 Query: 2024 LDKQYNTEINALSHL-YHKNVIKLV-ATHKCGPVYYIITELLPGGSLRSYLHN------- 2176 +E+ + + HKN+I L+ A + GP+Y +I E G+LR YL Sbjct: 529 DLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLY-VIVEYASKGNLREYLRARRPPGME 587 Query: 2177 --------PEHRPLPLERTISIALEIARGLEYVHSQGVVHRDIKPENILFDENFEVKIAD 2332 PE + + + +S ++ARG+EY+ SQ +HRD+ N+L EN +KIAD Sbjct: 588 YSFDINRVPEEQ-MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIAD 646 Query: 2333 FGIAXXXXXXXXXXXXXG---TYRWMAPEMIKRKPYNRKVDVYSFGLLLWEMVT-GRIPF 2500 FG+A +WMAPE + + Y + DV+SFG+L+WE+ T G P+ Sbjct: 647 FGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPY 706 Query: 2501 ENLSPVQVAYAVATDKLKPMDPQDYCPAAVRPLIEQCCALQPEKRPDFWQLVKTLEKIQS 2680 + PV+ + + + + MD C + ++ C P +RP F QLV+ L++I + Sbjct: 707 PGI-PVEELFKLLKEGHR-MDKPANCTNELYMMMRDCWQAVPSQRPTFKQLVEDLDRILT 764 Query: 2681 VMSQGGSLD 2707 + + LD Sbjct: 765 LTTNEEYLD 773
>Q00944:FAK1_CHICK Focal adhesion kinase 1 - Gallus gallus (Chicken)| Length = 1053 Score = 108 bits (269), Expect = 2e-22 Identities = 85/309 (27%), Positives = 141/309 (45%), Gaps = 22/309 (7%) Frame = +2 Query: 1814 ENVRSRTVSMAQA--------------VQSTVDWKLDKAKLLVGHSFASGAHSRLYRGLY 1951 + VRS TVS+++ + ST D+++ + ++ +G G +++G+Y Sbjct: 382 QGVRSHTVSVSETDDYAEIIDEEDTYTMPSTRDYEIQRERIELGRCIGEGQFGDVHQGIY 441 Query: 1952 --DDKP---VAIKFIRRPHEDPGGIMAAKLDKQYNTEINALSHLYHKNVIKLVATHKCGP 2116 + P VAIK + D + +++ E + H +++KL+ P Sbjct: 442 MSPENPAMAVAIKTCKNCTSD-------SVREKFLQEALTMRQFDHPHIVKLIGVITENP 494 Query: 2117 VYYIITELLPGGSLRSYLHNPEHRPLPLERTISIALEIARGLEYVHSQGVVHRDIKPENI 2296 V+ II EL G LRS+L + L L I A +++ L Y+ S+ VHRDI N+ Sbjct: 495 VW-IIMELCTLGELRSFLQVRKFS-LDLASLILYAYQLSTALAYLESKRFVHRDIAARNV 552 Query: 2297 LFDENFEVKIADFGIAXXXXXXXXXXXXXG--TYRWMAPEMIKRKPYNRKVDVYSFGLLL 2470 L VK+ DFG++ G +WMAPE I + + DV+ FG+ + Sbjct: 553 LVSATDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESINFRRFTSASDVWMFGVCM 612 Query: 2471 WE-MVTGRIPFENLSPVQVAYAVATDKLKPMDPQDYCPAAVRPLIEQCCALQPEKRPDFW 2647 WE ++ G PF+ + V + + PM P CP + L+ +C A P +RP F Sbjct: 613 WEILMHGVKPFQGVKNNDVIGRIENGERLPMPPN--CPPTLYSLMTKCWAYDPSRRPRFT 670 Query: 2648 QLVKTLEKI 2674 +L L I Sbjct: 671 ELKAQLSTI 679
>Q9HFW2:CLA4_ASHGO Serine/threonine-protein kinase CLA4 - Ashbya gossypii (Yeast)| (Eremothecium gossypii) Length = 793 Score = 108 bits (269), Expect = 2e-22 Identities = 60/211 (28%), Positives = 104/211 (49%), Gaps = 7/211 (3%) Frame = +2 Query: 2045 EINALSHLYHKNVIKLVATH-KCGPVYYIITELLPGGSLRSYLHNP-----EHRPLPLER 2206 EI + HKN++ + + K +++ E + GGSL + N P+ + Sbjct: 561 EILVMKDSQHKNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDVIENSIGSDASESPMTEPQ 620 Query: 2207 TISIALEIARGLEYVHSQGVVHRDIKPENILFDENFEVKIADFGI-AXXXXXXXXXXXXX 2383 I E +GL+++H + ++HRDIK +N+L D + VKI DFG A Sbjct: 621 IAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTHGRVKITDFGFCAKLTDKRSKRATMV 680 Query: 2384 GTYRWMAPEMIKRKPYNRKVDVYSFGLLLWEMVTGRIPFENLSPVQVAYAVATDKLKPMD 2563 GT WMAPE++K++ Y+ KVDV+S G++ EM+ G P+ N P++ Y +AT+ + Sbjct: 681 GTPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLEGEPPYLNEEPLKALYLIATNGTPKLK 740 Query: 2564 PQDYCPAAVRPLIEQCCALQPEKRPDFWQLV 2656 + ++ + C + R +L+ Sbjct: 741 HPELLSLEIKRFLSVCLCVDVRYRASTEELL 771
>Q9UQB9:AURKC_HUMAN Serine/threonine-protein kinase 13 - Homo sapiens (Human)| Length = 309 Score = 108 bits (269), Expect = 2e-22 Identities = 80/257 (31%), Positives = 119/257 (46%), Gaps = 3/257 (1%) Frame = +2 Query: 1898 VGHSFASGAHSRLYRGLYDDKP--VAIKFIRRPHEDPGGIMAAKLDKQYNTEINALSHLY 2071 +G G +Y + VA+K + + + G L+ Q EI +HL Sbjct: 45 IGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEG-----LEHQLRREIEIQAHLQ 99 Query: 2072 HKNVIKLVATHKCGPVYYIITELLPGGSLRSYLHNPEHRPLPLERTISIALEIARGLEYV 2251 H N+++L Y+I E P G L L E L +RT +I E+A L Y Sbjct: 100 HPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEK--LDEQRTATIIEELADALTYC 157 Query: 2252 HSQGVVHRDIKPENILFDENFEVKIADFGIAXXXXXXXXXXXXXGTYRWMAPEMIKRKPY 2431 H + V+HRDIKPEN+L EVKIADFG + GT ++ PEMI+ + Y Sbjct: 158 HDKKVIHRDIKPENLLLGFRGEVKIADFGWS-VHTPSLRRKTMCGTLDYLPPEMIEGRTY 216 Query: 2432 NRKVDVYSFGLLLWEMVTGRIPFENLSPVQVAYAV-ATDKLKPMDPQDYCPAAVRPLIEQ 2608 + KVD++ G+L +E++ G PFE+ S + + D P+ P R LI + Sbjct: 217 DEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLS----MPLGARDLISR 272 Query: 2609 CCALQPEKRPDFWQLVK 2659 QP +R Q++K Sbjct: 273 LLRYQPLERLPLAQILK 289 Database: uniprot_sprot.fasta.out Posted date: Jul 19, 2007 5:58 PM Number of letters in database: 100,686,439 Number of sequences in database: 274,295 Lambda K H 0.318 0.134 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 274295 Number of Hits to DB: 565,418,161 Number of extensions: 13601425 Number of successful extensions: 57045 Number of sequences better than 10.0: 2781 Number of HSP's gapped: 51774 Number of HSP's successfully gapped: 2994 Length of query: 1005 Length of database: 100,686,439 Length adjustment: 123 Effective length of query: 882 Effective length of database: 66,948,154 Effective search space: 59048271828 Effective search space used: 59048271828 Neighboring words threshold: 12 Window for multiple hits: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)
