ナショナルバイオリソースプロジェクト
-Barley Genetic Resources Database-
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| Clone Name | bast78c04 |
|---|---|
| Clone Library Name | barley_pub |
>NORK_MEDTR (Q8L4H4) Nodulation receptor kinase precursor (EC 2.7.11.1) (Does not| make infections protein 2) (Symbiosis receptor-like kinase) (MtSYMRK) Length = 925 Score = 164 bits (414), Expect = 2e-40 Identities = 83/160 (51%), Positives = 110/160 (68%), Gaps = 2/160 (1%) Frame = +3 Query: 3 LQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEK 182 L D +VAVK + S QG REF E+ LLS ++H +LV L+GYC+E ++ ILVY +M Sbjct: 615 LDDGQEVAVKVRSSTSTQGTREFDNELNLLSAIQHENLVPLLGYCNEYDQQILVYPFMSN 674 Query: 183 GTLKSHLYG--SDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENL 356 G+L LYG S L W R+ I +GAARGL Y HT +S+IHRDVKS+NILLD+++ Sbjct: 675 GSLLDRLYGEASKRKILDWPTRLSIALGAARGLAYLHTFPGRSVIHRDVKSSNILLDQSM 734 Query: 357 MAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQ 476 AKV+DFG SK P+ ++VS V+G+ GYLDPEYY+ Q Sbjct: 735 CAKVADFGFSKYAPQEGDSYVSLEVRGTAGYLDPEYYKTQ 774
>NORK_PEA (Q8LKZ1) Nodulation receptor kinase precursor (EC 2.7.11.1)| Length = 924 Score = 161 bits (408), Expect = 8e-40 Identities = 82/160 (51%), Positives = 108/160 (67%), Gaps = 2/160 (1%) Frame = +3 Query: 3 LQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEK 182 L D +VAVK + S QG REF E+ LLS ++H +LV L+GYC+E ++ ILVY +M Sbjct: 614 LDDGQEVAVKVRSATSTQGTREFDNELNLLSAIQHENLVPLLGYCNEYDQQILVYPFMSN 673 Query: 183 GTLKSHLYGSDMPP--LGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENL 356 G+L LYG L W R+ I +GAARGL Y HT +S+IHRDVKS+NILLD ++ Sbjct: 674 GSLLDRLYGEPAKRKILDWPTRLSIALGAARGLAYLHTFPGRSVIHRDVKSSNILLDHSM 733 Query: 357 MAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQ 476 AKV+DFG SK P+ ++VS V+G+ GYLDPEYY+ Q Sbjct: 734 CAKVADFGFSKYAPQEGDSYVSLEVRGTAGYLDPEYYKTQ 773
>CX32_ARATH (P27450) Probable serine/threonine-protein kinase Cx32, chloroplast| precursor (EC 2.7.11.1) Length = 419 Score = 153 bits (387), Expect = 2e-37 Identities = 75/148 (50%), Positives = 107/148 (72%) Frame = +3 Query: 21 VAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSH 200 VA+KR N +S QG E+R+E+ L L HR+LV L+GYC E E++LVYE+M KG+L+SH Sbjct: 121 VAIKRLNSESVQGFAEWRSEVNFLGMLSHRNLVKLLGYCREDKELLLVYEFMPKGSLESH 180 Query: 201 LYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDFG 380 L+ + P W R++I IGAARGL + H+ + +I+RD K++NILLD N AK+SDFG Sbjct: 181 LFRRN-DPFPWDLRIKIVIGAARGLAFLHS-LQREVIYRDFKASNILLDSNYDAKLSDFG 238 Query: 381 LSKTGPELDQTHVSTAVKGSFGYLDPEY 464 L+K GP +++HV+T + G++GY PEY Sbjct: 239 LAKLGPADEKSHVTTRIMGTYGYAAPEY 266
>CRI4_MAIZE (O24585) Putative receptor protein kinase CRINKLY4 precursor (EC| 2.7.11.1) Length = 901 Score = 150 bits (378), Expect = 3e-36 Identities = 78/161 (48%), Positives = 106/161 (65%), Gaps = 5/161 (3%) Frame = +3 Query: 3 LQDSTKVAVKRGNQKSH--QGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYM 176 L+D T VAVKR + S + +EF E++LLS L H HL++L+GYC++ +E +LVYE+M Sbjct: 524 LRDGTVVAVKRAIKASDVKKSSKEFHNELDLLSRLNHAHLLNLLGYCEDGSERLLVYEFM 583 Query: 177 EKGTLKSHLYGSD---MPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLD 347 G+L HL+G D L W +RV I + AARG+ Y H +IHRD+KS+NIL+D Sbjct: 584 AHGSLYQHLHGKDPNLKKRLNWARRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILID 643 Query: 348 ENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYR 470 E+ A+V+DFGLS GP T +S G+ GYLDPEYYR Sbjct: 644 EDHNARVADFGLSILGPADSGTPLSELPAGTLGYLDPEYYR 684
>SIRK_ARATH (O64483) Senescence-induced receptor-like serine/threonine-protein| kinase precursor (FLG22-induced receptor-like kinase 1) Length = 876 Score = 150 bits (378), Expect = 3e-36 Identities = 74/150 (49%), Positives = 101/150 (67%) Frame = +3 Query: 18 KVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKS 197 +VAVK +++S QG +EFR E++LL + H +L SL+GYC+E N M+L+YEYM L Sbjct: 597 QVAVKVLSEESAQGYKEFRAEVDLLMRVHHTNLTSLVGYCNEINHMVLIYEYMANENLGD 656 Query: 198 HLYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDF 377 +L G L W++R++I + AA+GL Y H G I+HRDVK NILL+E L AK++DF Sbjct: 657 YLAGKRSFILSWEERLKISLDAAQGLEYLHNGCKPPIVHRDVKPTNILLNEKLQAKMADF 716 Query: 378 GLSKTGPELDQTHVSTAVKGSFGYLDPEYY 467 GLS++ +ST V GS GYLDPEYY Sbjct: 717 GLSRSFSVEGSGQISTVVAGSIGYLDPEYY 746
>NAK_ARATH (P43293) Probable serine/threonine-protein kinase NAK (EC 2.7.11.1)| Length = 389 Score = 146 bits (368), Expect = 4e-35 Identities = 76/150 (50%), Positives = 101/150 (67%), Gaps = 2/150 (1%) Frame = +3 Query: 21 VAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSH 200 +AVKR NQ+ QG RE+ EI L L H +LV LIGYC E+ +LVYE+M +G+L++H Sbjct: 103 IAVKRLNQEGFQGHREWLAEINYLGQLDHPNLVKLIGYCLEEEHRLLVYEFMTRGSLENH 162 Query: 201 LY--GSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSD 374 L+ G+ PL W RV + +GAARGL + H +I+RD K++NILLD N AK+SD Sbjct: 163 LFRRGTFYQPLSWNTRVRMALGAARGLAFLHNA-QPQVIYRDFKASNILLDSNYNAKLSD 221 Query: 375 FGLSKTGPELDQTHVSTAVKGSFGYLDPEY 464 FGL++ GP D +HVST V G+ GY PEY Sbjct: 222 FGLARDGPMGDNSHVSTRVMGTQGYAAPEY 251
>APK1A_ARATH (Q06548) Protein kinase APK1A, chloroplast precursor (EC 2.7.11.1)| Length = 410 Score = 145 bits (366), Expect = 6e-35 Identities = 73/150 (48%), Positives = 102/150 (68%), Gaps = 2/150 (1%) Frame = +3 Query: 21 VAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSH 200 +AVK+ NQ QG +E+ E+ L HRHLV LIGYC E +LVYE+M +G+L++H Sbjct: 103 IAVKKLNQDGWQGHQEWLAEVNYLGQFSHRHLVKLIGYCLEDEHRLLVYEFMPRGSLENH 162 Query: 201 LY--GSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSD 374 L+ G PL WK R+++ +GAA+GL + H+ + +I+RD K++NILLD AK+SD Sbjct: 163 LFRRGLYFQPLSWKLRLKVALGAAKGLAFLHSSETR-VIYRDFKTSNILLDSEYNAKLSD 221 Query: 375 FGLSKTGPELDQTHVSTAVKGSFGYLDPEY 464 FGL+K GP D++HVST V G+ GY PEY Sbjct: 222 FGLAKDGPIGDKSHVSTRVMGTHGYAAPEY 251
>TMK1_ARATH (P43298) Putative receptor protein kinase TMK1 precursor (EC| 2.7.11.1) Length = 942 Score = 145 bits (365), Expect = 8e-35 Identities = 75/159 (47%), Positives = 107/159 (67%), Gaps = 5/159 (3%) Frame = +3 Query: 3 LQDSTKVAVKRGNQK--SHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYM 176 L D TK+AVKR + +G EF++EI +L+ +RHRHLV+L+GYC + NE +LVYEYM Sbjct: 607 LHDGTKIAVKRMENGVIAGKGFAEFKSEIAVLTKVRHRHLVTLLGYCLDGNEKLLVYEYM 666 Query: 177 EKGTLKSHLY---GSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLD 347 +GTL HL+ + PL WK+R+ + + ARG+ Y H +S IHRD+K +NILL Sbjct: 667 PQGTLSRHLFEWSEEGLKPLLWKQRLTLALDVARGVEYLHGLAHQSFIHRDLKPSNILLG 726 Query: 348 ENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEY 464 +++ AKV+DFGL + PE + + T + G+FGYL PEY Sbjct: 727 DDMRAKVADFGLVRLAPE-GKGSIETRIAGTFGYLAPEY 764
>RLCK7_ARATH (Q9LQQ8) Probable serine/threonine-protein kinase RLCKVII (EC| 2.7.11.1) Length = 423 Score = 145 bits (365), Expect = 8e-35 Identities = 73/150 (48%), Positives = 101/150 (67%), Gaps = 2/150 (1%) Frame = +3 Query: 21 VAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSH 200 VA+K+ ++ QG+REF E+ LS H +LV LIG+C E ++ +LVYEYM +G+L+ H Sbjct: 129 VAIKQLDRNGVQGIREFVVEVLTLSLADHPNLVKLIGFCAEGDQRLLVYEYMPQGSLEDH 188 Query: 201 LY--GSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSD 374 L+ S PL W R++I GAARGL Y H +I+RD+K +NILL E+ K+SD Sbjct: 189 LHVLPSGKKPLDWNTRMKIAAGAARGLEYLHDRMTPPVIYRDLKCSNILLGEDYQPKLSD 248 Query: 375 FGLSKTGPELDQTHVSTAVKGSFGYLDPEY 464 FGL+K GP D+THVST V G++GY P+Y Sbjct: 249 FGLAKVGPSGDKTHVSTRVMGTYGYCAPDY 278
>PBS1_ARATH (Q9FE20) Serine/threonine-protein kinase PBS1 (EC 2.7.11.1)| (AvrPphB susceptible protein 1) Length = 456 Score = 144 bits (362), Expect = 2e-34 Identities = 75/152 (49%), Positives = 104/152 (68%), Gaps = 4/152 (2%) Frame = +3 Query: 21 VAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSH 200 VAVK+ ++ QG REF E+ +LS L H +LV+LIGYC + ++ +LVYE+M G+L+ H Sbjct: 112 VAVKQLDRNGLQGNREFLVEVLMLSLLHHPNLVNLIGYCADGDQRLLVYEFMPLGSLEDH 171 Query: 201 LYGSDMPP----LGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKV 368 L+ D+PP L W R++I GAA+GL + H +I+RD KS+NILLDE K+ Sbjct: 172 LH--DLPPDKEALDWNMRMKIAAGAAKGLEFLHDKANPPVIYRDFKSSNILLDEGFHPKL 229 Query: 369 SDFGLSKTGPELDQTHVSTAVKGSFGYLDPEY 464 SDFGL+K GP D++HVST V G++GY PEY Sbjct: 230 SDFGLAKLGPTGDKSHVSTRVMGTYGYCAPEY 261
>APK1B_ARATH (P46573) Protein kinase APK1B, chloroplast precursor (EC 2.7.11.1)| Length = 412 Score = 142 bits (359), Expect = 4e-34 Identities = 71/150 (47%), Positives = 101/150 (67%), Gaps = 2/150 (1%) Frame = +3 Query: 21 VAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSH 200 +AVK+ NQ QG +E+ E+ L H +LV LIGYC E +LVYE+M +G+L++H Sbjct: 104 IAVKKLNQDGWQGHQEWLAEVNYLGQFSHPNLVKLIGYCLEDEHRLLVYEFMPRGSLENH 163 Query: 201 LY--GSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSD 374 L+ GS PL W R+++ +GAA+GL + H S+I+RD K++NILLD AK+SD Sbjct: 164 LFRRGSYFQPLSWTLRLKVALGAAKGLAFLHNA-ETSVIYRDFKTSNILLDSEYNAKLSD 222 Query: 375 FGLSKTGPELDQTHVSTAVKGSFGYLDPEY 464 FGL+K GP D++HVST + G++GY PEY Sbjct: 223 FGLAKDGPTGDKSHVSTRIMGTYGYAAPEY 252
>EXS_ARATH (Q9LYN8) Leucine-rich repeat receptor protein kinase EXS precursor| (EC 2.7.11.1) (Extra sporogenous cells protein) (EXCESS MICROSPOROCYTES1 protein) Length = 1192 Score = 138 bits (347), Expect = 1e-32 Identities = 72/150 (48%), Positives = 99/150 (66%), Gaps = 2/150 (1%) Frame = +3 Query: 21 VAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSH 200 VAVK+ ++ QG REF E+E L ++H +LVSL+GYC E +LVYEYM G+L Sbjct: 942 VAVKKLSEAKTQGNREFMAEMETLGKVKHPNLVSLLGYCSFSEEKLLVYEYMVNGSLDHW 1001 Query: 201 LYGSD--MPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSD 374 L + L W KR++I +GAARGL + H GF IIHRD+K++NILLD + KV+D Sbjct: 1002 LRNQTGMLEVLDWSKRLKIAVGAARGLAFLHHGFIPHIIHRDIKASNILLDGDFEPKVAD 1061 Query: 375 FGLSKTGPELDQTHVSTAVKGSFGYLDPEY 464 FGL++ ++HVST + G+FGY+ PEY Sbjct: 1062 FGLARL-ISACESHVSTVIAGTFGYIPPEY 1090
>BRI1_LYCPE (Q8L899) Systemin receptor SR160 precursor (EC 2.7.11.1)| (Brassinosteroid LRR receptor kinase) Length = 1207 Score = 134 bits (338), Expect = 1e-31 Identities = 74/159 (46%), Positives = 105/159 (66%), Gaps = 3/159 (1%) Frame = +3 Query: 3 LQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEK 182 L+D + VA+K+ S QG REF E+E + ++HR+LV L+GYC E +LVYEYM+ Sbjct: 907 LKDGSVVAIKKLIHVSGQGDREFTAEMETIGKIKHRNLVPLLGYCKVGEERLLVYEYMKY 966 Query: 183 GTLKSHLYGSDMP--PLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENL 356 G+L+ L+ L W R +I IGAARGL + H IIHRD+KS+N+LLDENL Sbjct: 967 GSLEDVLHDRKKTGIKLNWPARRKIAIGAARGLAFLHHNCIPHIIHRDMKSSNVLLDENL 1026 Query: 357 MAKVSDFGLSKTGPELDQTHVS-TAVKGSFGYLDPEYYR 470 A+VSDFG+++ +D TH+S + + G+ GY+ PEYY+ Sbjct: 1027 EARVSDFGMARLMSAMD-THLSVSTLAGTPGYVPPEYYQ 1064
>BRI1_LYCES (Q8GUQ5) Brassinosteroid LRR receptor kinase precursor (EC 2.7.11.1)| (tBRI1) (Altered brassinolide sensitivity 1) (Systemin receptor SR160) Length = 1207 Score = 134 bits (336), Expect = 2e-31 Identities = 74/159 (46%), Positives = 105/159 (66%), Gaps = 3/159 (1%) Frame = +3 Query: 3 LQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEK 182 L+D + VA+K+ S QG REF E+E + ++HR+LV L+GYC E +LVYEYM+ Sbjct: 907 LKDGSVVAIKKLIHVSGQGDREFTAEMETIGKIKHRNLVPLLGYCKVGEERLLVYEYMKY 966 Query: 183 GTLKSHLYGSDMP--PLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENL 356 G+L+ L+ L W R +I IGAARGL + H IIHRD+KS+N+LLDENL Sbjct: 967 GSLEDVLHDRKKIGIKLNWPARRKIAIGAARGLAFLHHNCIPHIIHRDMKSSNVLLDENL 1026 Query: 357 MAKVSDFGLSKTGPELDQTHVS-TAVKGSFGYLDPEYYR 470 A+VSDFG+++ +D TH+S + + G+ GY+ PEYY+ Sbjct: 1027 EARVSDFGMARLMSAMD-THLSVSTLAGTPGYVPPEYYQ 1064
>BRI1_ARATH (O22476) BRASSINOSTEROID INSENSITIVE 1 precursor (EC 2.7.11.1)| (AtBRI1) (Brassinosteroid LRR receptor kinase) Length = 1196 Score = 134 bits (336), Expect = 2e-31 Identities = 72/159 (45%), Positives = 107/159 (67%), Gaps = 3/159 (1%) Frame = +3 Query: 3 LQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEK 182 L+D + VA+K+ S QG REF E+E + ++HR+LV L+GYC +E +LVYE+M+ Sbjct: 902 LKDGSAVAIKKLIHVSGQGDREFMAEMETIGKIKHRNLVPLLGYCKVGDERLLVYEFMKY 961 Query: 183 GTLKSHLYGSDMP--PLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENL 356 G+L+ L+ L W R +I IG+ARGL + H + IIHRD+KS+N+LLDENL Sbjct: 962 GSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAFLHHNCSPHIIHRDMKSSNVLLDENL 1021 Query: 357 MAKVSDFGLSKTGPELDQTHVS-TAVKGSFGYLDPEYYR 470 A+VSDFG+++ +D TH+S + + G+ GY+ PEYY+ Sbjct: 1022 EARVSDFGMARLMSAMD-THLSVSTLAGTPGYVPPEYYQ 1059
>BAK1_ARATH (Q94F62) BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1| precursor (EC 2.7.11.1) (BRI1-associated receptor kinase 1) (Somatic embryogenesis receptor-like kinase 3) Length = 615 Score = 133 bits (335), Expect = 2e-31 Identities = 76/157 (48%), Positives = 99/157 (63%), Gaps = 3/157 (1%) Frame = +3 Query: 3 LQDSTKVAVKRGNQKSHQGLR-EFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYME 179 L D T VAVKR ++ QG +F+TE+E++S HR+L+ L G+C E +LVY YM Sbjct: 308 LADGTLVAVKRLKEERTQGGELQFQTEVEMISMAVHRNLLRLRGFCMTPTERLLVYPYMA 367 Query: 180 KGTLKSHLYG--SDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDEN 353 G++ S L PPL W KR I +G+ARGL Y H IIHRDVK+ANILLDE Sbjct: 368 NGSVASCLRERPESQPPLDWPKRQRIALGSARGLAYLHDHCDPKIIHRDVKAANILLDEE 427 Query: 354 LMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEY 464 A V DFGL+K + THV+TAV+G+ G++ PEY Sbjct: 428 FEAVVGDFGLAKL-MDYKDTHVTTAVRGTIGHIAPEY 463
>PSKR_DAUCA (Q8LPB4) Phytosulfokine receptor precursor (EC 2.7.11.1)| (Phytosulfokine LRR receptor kinase) Length = 1021 Score = 133 bits (335), Expect = 2e-31 Identities = 72/156 (46%), Positives = 102/156 (65%), Gaps = 2/156 (1%) Frame = +3 Query: 3 LQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEK 182 L D TKVA+KR + + Q REF+ E+E LS +H +LV L+GYC+ +N+ +L+Y YM+ Sbjct: 762 LPDGTKVAIKRLSGDTGQMDREFQAEVETLSRAQHPNLVHLLGYCNYKNDKLLIYSYMDN 821 Query: 183 GTLKSHLYGS-DMPP-LGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENL 356 G+L L+ D PP L WK R+ I GAA GL Y H I+HRD+KS+NILL + Sbjct: 822 GSLDYWLHEKVDGPPSLDWKTRLRIARGAAEGLAYLHQSCEPHILHRDIKSSNILLSDTF 881 Query: 357 MAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEY 464 +A ++DFGL++ D THV+T + G+ GY+ PEY Sbjct: 882 VAHLADFGLARLILPYD-THVTTDLVGTLGYIPPEY 916
>BRL2_ARATH (Q9ZPS9) Serine/threonine-protein kinase BRI1-like 2 precursor (EC| 2.7.11.1) (BRASSINOSTEROID INSENSITIVE 1-like protein 2) (Protein VASCULAR HIGHWAY 1) Length = 1143 Score = 132 bits (332), Expect = 6e-31 Identities = 72/161 (44%), Positives = 109/161 (67%), Gaps = 5/161 (3%) Frame = +3 Query: 3 LQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEK 182 L+D + VA+K+ + S QG REF E+E L ++HR+LV L+GYC E +LVYE+M+ Sbjct: 857 LKDGSSVAIKKLIRLSCQGDREFMAEMETLGKIKHRNLVPLLGYCKIGEERLLVYEFMQY 916 Query: 183 GTLKSHLYGSDMPP----LGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDE 350 G+L+ L+G LGW++R +I GAA+GL + H IIHRD+KS+N+LLD+ Sbjct: 917 GSLEEVLHGPRTGEKRRILGWEERKKIAKGAAKGLCFLHHNCIPHIIHRDMKSSNVLLDQ 976 Query: 351 NLMAKVSDFGLSKTGPELDQTHVS-TAVKGSFGYLDPEYYR 470 ++ A+VSDFG+++ LD TH+S + + G+ GY+ PEYY+ Sbjct: 977 DMEARVSDFGMARLISALD-THLSVSTLAGTPGYVPPEYYQ 1016
>BRL3_ARATH (Q9LJF3) Serine/threonine-protein kinase BRI1-like 3 precursor (EC| 2.7.11.1) (BRASSINOSTEROID INSENSITIVE 1-like protein 3) Length = 1164 Score = 131 bits (330), Expect = 9e-31 Identities = 72/160 (45%), Positives = 106/160 (66%), Gaps = 4/160 (2%) Frame = +3 Query: 3 LQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEK 182 L D + VA+K+ Q + QG REF E+E + ++HR+LV L+GYC E +LVYEYM+ Sbjct: 877 LADGSVVAIKKLIQVTGQGDREFMAEMETIGKIKHRNLVPLLGYCKIGEERLLVYEYMKY 936 Query: 183 GTLKSHLYGSDMPP---LGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDEN 353 G+L++ L+ L W R +I IGAARGL + H IIHRD+KS+N+LLD++ Sbjct: 937 GSLETVLHEKTKKGGIFLDWSARKKIAIGAARGLAFLHHSCIPHIIHRDMKSSNVLLDQD 996 Query: 354 LMAKVSDFGLSKTGPELDQTHVS-TAVKGSFGYLDPEYYR 470 +A+VSDFG+++ LD TH+S + + G+ GY+ PEYY+ Sbjct: 997 FVARVSDFGMARLVSALD-THLSVSTLAGTPGYVPPEYYQ 1035
>BRL1_ARATH (Q9ZWC8) Serine/threonine-protein kinase BRI1-like 1 precursor (EC| 2.7.11.1) (BRASSINOSTEROID INSENSITIVE 1-like protein 1) Length = 1166 Score = 130 bits (328), Expect = 2e-30 Identities = 72/161 (44%), Positives = 106/161 (65%), Gaps = 5/161 (3%) Frame = +3 Query: 3 LQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEK 182 L+D + VA+K+ + + QG REF E+E + ++HR+LV L+GYC E +LVYEYM+ Sbjct: 878 LRDGSVVAIKKLIRITGQGDREFMAEMETIGKIKHRNLVPLLGYCKVGEERLLVYEYMKW 937 Query: 183 GTLKSHLYGSDMPP----LGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDE 350 G+L++ L+ L W R +I IGAARGL + H IIHRD+KS+N+LLDE Sbjct: 938 GSLETVLHEKSSKKGGIYLNWAARKKIAIGAARGLAFLHHSCIPHIIHRDMKSSNVLLDE 997 Query: 351 NLMAKVSDFGLSKTGPELDQTHVS-TAVKGSFGYLDPEYYR 470 + A+VSDFG+++ LD TH+S + + G+ GY+ PEYY+ Sbjct: 998 DFEARVSDFGMARLVSALD-THLSVSTLAGTPGYVPPEYYQ 1037
>PSKR_ARATH (Q9ZVR7) Putative phytosulfokine receptor precursor (EC 2.7.11.1)| (Phytosulfokine LRR receptor kinase) Length = 1008 Score = 129 bits (324), Expect = 5e-30 Identities = 71/156 (45%), Positives = 99/156 (63%), Gaps = 2/156 (1%) Frame = +3 Query: 3 LQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEK 182 L D KVA+K+ + Q REF E+E LS +H +LV L G+C +N+ +L+Y YME Sbjct: 753 LPDGKKVAIKKLSGDCGQIEREFEAEVETLSRAQHPNLVLLRGFCFYKNDRLLIYSYMEN 812 Query: 183 GTLKSHLYGSDMPP--LGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENL 356 G+L L+ + P L WK R+ I GAA+GL Y H G I+HRD+KS+NILLDEN Sbjct: 813 GSLDYWLHERNDGPALLKWKTRLRIAQGAAKGLLYLHEGCDPHILHRDIKSSNILLDENF 872 Query: 357 MAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEY 464 + ++DFGL++ +THVST + G+ GY+ PEY Sbjct: 873 NSHLADFGLARLMSPY-ETHVSTDLVGTLGYIPPEY 907
>SRK6_BRAOE (Q09092) Putative serine/threonine-protein kinase receptor precursor| (EC 2.7.11.1) (S-receptor kinase) (SRK) Length = 849 Score = 128 bits (321), Expect = 1e-29 Identities = 69/156 (44%), Positives = 103/156 (66%), Gaps = 2/156 (1%) Frame = +3 Query: 3 LQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEK 182 L D ++AVKR ++ S QG EF E+ L++ L+H +LV ++G C E +E +L+YEY+E Sbjct: 547 LLDGKEIAVKRLSKTSVQGTDEFMNEVTLIARLQHINLVQVLGCCIEGDEKMLIYEYLEN 606 Query: 183 GTLKSHLYGSDM-PPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLM 359 +L S+L+G L W +R +I G ARGL Y H IIHRD+K +NILLD+N++ Sbjct: 607 LSLDSYLFGKTRRSKLNWNERFDITNGVARGLLYLHQDSRFRIIHRDLKVSNILLDKNMI 666 Query: 360 AKVSDFGLSKTGPELDQTHVST-AVKGSFGYLDPEY 464 K+SDFG+++ E D+T +T V G++GY+ PEY Sbjct: 667 PKISDFGMARIF-ERDETEANTMKVVGTYGYMSPEY 701
>CLV1_ARATH (Q9SYQ8) Receptor protein kinase CLAVATA1 precursor (EC 2.7.11.1)| Length = 980 Score = 116 bits (290), Expect = 4e-26 Identities = 63/149 (42%), Positives = 90/149 (60%) Frame = +3 Query: 18 KVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKS 197 K V RG +S G F EI+ L +RHRH+V L+GY ++ +L+YEYM G+L Sbjct: 720 KRLVGRGTGRSDHG---FTAEIQTLGRIRHRHIVRLLGYVANKDTNLLLYEYMPNGSLGE 776 Query: 198 HLYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDF 377 L+GS L W+ R + + AA+GL Y H + I+HRDVKS NILLD + A V+DF Sbjct: 777 LLHGSKGGHLQWETRHRVAVEAAKGLCYLHHDCSPLILHRDVKSNNILLDSDFEAHVADF 836 Query: 378 GLSKTGPELDQTHVSTAVKGSFGYLDPEY 464 GL+K + + +++ GS+GY+ PEY Sbjct: 837 GLAKFLVDGAASECMSSIAGSYGYIAPEY 865
>IRAK4_HUMAN (Q9NWZ3) Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1)| (IRAK-4) (NY-REN-64 antigen) Length = 460 Score = 107 bits (267), Expect = 2e-23 Identities = 64/178 (35%), Positives = 104/178 (58%), Gaps = 10/178 (5%) Frame = +3 Query: 9 DSTKVAVKR----GNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYM 176 ++T VAVK+ + + + ++F EI++++ +H +LV L+G+ + +++ LVY YM Sbjct: 206 NNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYM 265 Query: 177 EKGTLKSHLYGSD-MPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDEN 353 G+L L D PPL W R +I GAA G+++ H IHRD+KSANILLDE Sbjct: 266 PNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHH---IHRDIKSANILLDEA 322 Query: 354 LMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQS*P-----TVGCVLIRV 512 AK+SDFGL++ + QT +++ + G+ Y+ PE R + P + G VL+ + Sbjct: 323 FTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEI 380
>IRAK4_MOUSE (Q8R4K2) Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1)| (IRAK-4) Length = 459 Score = 105 bits (261), Expect = 9e-23 Identities = 54/142 (38%), Positives = 85/142 (59%), Gaps = 1/142 (0%) Frame = +3 Query: 63 REFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYGSD-MPPLGWKK 239 ++F EI++++ +H +LV L+G+ + + + LVY YM G+L L D PPL W Sbjct: 228 QQFDQEIKVMATCQHENLVELLGFSSDSDNLCLVYAYMPNGSLLDRLSCLDGTPPLSWHT 287 Query: 240 RVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSKTGPELDQTHV 419 R ++ G A G+ + H IHRD+KSANILLD++ AK+SDFGL++ L QT + Sbjct: 288 RCKVAQGTANGIRFLHENHH---IHRDIKSANILLDKDFTAKISDFGLARASARLAQTVM 344 Query: 420 STAVKGSFGYLDPEYYRRQS*P 485 ++ + G+ Y+ PE R + P Sbjct: 345 TSRIVGTTAYMAPEALRGEITP 366
>RLK5_ARATH (P47735) Receptor-like protein kinase 5 precursor (EC 2.7.11.1)| Length = 999 Score = 103 bits (257), Expect = 3e-22 Identities = 65/168 (38%), Positives = 88/168 (52%), Gaps = 14/168 (8%) Frame = +3 Query: 3 LQDSTKVAVKRGNQKSHQGLRE----------FRTEIELLSGLRHRHLVSLIGYCDEQNE 152 L+ VAVK+ N+ G E F E+E L +RH+ +V L C + Sbjct: 702 LRGGEVVAVKKLNKSVKGGDDEYSSDSLNRDVFAAEVETLGTIRHKSIVRLWCCCSSGDC 761 Query: 153 MILVYEYMEKGTLKSHLYGSDMPP--LGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVK 326 +LVYEYM G+L L+G LGW +R+ I + AA GL Y H I+HRDVK Sbjct: 762 KLLVYEYMPNGSLADVLHGDRKGGVVLGWPERLRIALDAAEGLSYLHHDCVPPIVHRDVK 821 Query: 327 SANILLDENLMAKVSDFGLSKTGPELDQ--THVSTAVKGSFGYLDPEY 464 S+NILLD + AKV+DFG++K G + + GS GY+ PEY Sbjct: 822 SSNILLDSDYGAKVADFGIAKVGQMSGSKTPEAMSGIAGSCGYIAPEY 869
>IRAK1_MOUSE (Q62406) Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1)| (IRAK-1) (IRAK) (Pelle-like protein kinase) (mPLK) Length = 710 Score = 102 bits (253), Expect = 8e-22 Identities = 60/166 (36%), Positives = 93/166 (56%), Gaps = 13/166 (7%) Frame = +3 Query: 12 STKVAVKRGNQKSH----QGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYME 179 +T AVKR +++ + F TE+E LS RH ++V GYC E LVY ++ Sbjct: 233 NTTYAVKRLKEEADLEWTMVKQSFLTEVEQLSRFRHPNIVDFAGYCAESGLYCLVYGFLP 292 Query: 180 KGTLKS--HLYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDEN 353 G+L+ HL PL W +R++I +G AR + + H + S+IH D+KS+N+LLDE Sbjct: 293 NGSLEDQLHLQTQACSPLSWPQRLDILLGTARAIQFLHQD-SPSLIHGDIKSSNVLLDER 351 Query: 354 LMAKVSDFGLSK----TGPELDQTHV---STAVKGSFGYLDPEYYR 470 LM K+ DFGL++ G + Q+ ++ V+G+ YL EY + Sbjct: 352 LMPKLGDFGLARFSRFAGAKASQSSTVARTSTVRGTLAYLPEEYIK 397
>KPRO_MAIZE (P17801) Putative receptor protein kinase ZmPK1 precursor (EC| 2.7.11.1) Length = 817 Score = 100 bits (248), Expect = 3e-21 Identities = 58/156 (37%), Positives = 90/156 (57%), Gaps = 2/156 (1%) Frame = +3 Query: 3 LQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEK 182 L+D VAVK+ + QG F+ E+ ++ + H +LV + G+C E + +LV EY+E Sbjct: 553 LEDDRHVAVKK-LENVRQGKEVFQAELSVIGRINHMNLVRIWGFCSEGSHRLLVSEYVEN 611 Query: 183 GTLKSHLY--GSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENL 356 G+L + L+ G ++ L W+ R I +G A+GL Y H + +IH DVK NILLD+ Sbjct: 612 GSLANILFSEGGNIL-LDWEGRFNIALGVAKGLAYLHHECLEWVIHCDVKPENILLDQAF 670 Query: 357 MAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEY 464 K++DFGL K T + V+G+ GY+ PE+ Sbjct: 671 EPKITDFGLVKLLNRGGSTQNVSHVRGTLGYIAPEW 706
>IRAK1_HUMAN (P51617) Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1)| (IRAK-1) Length = 712 Score = 98.2 bits (243), Expect = 1e-20 Identities = 53/145 (36%), Positives = 83/145 (57%), Gaps = 9/145 (6%) Frame = +3 Query: 63 REFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYGSDM--PPLGWK 236 + F TE+E LS RH ++V GYC + LVY ++ G+L+ L+ PPL W Sbjct: 254 QSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWP 313 Query: 237 KRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSK----TGPEL 404 +R++I +G AR + + H + S+IH D+KS+N+LLDE L K+ DFGL++ G Sbjct: 314 QRLDILLGTARAIQFLHQD-SPSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSP 372 Query: 405 DQTHV---STAVKGSFGYLDPEYYR 470 Q+ + + V+G+ YL EY + Sbjct: 373 SQSSMVARTQTVRGTLAYLPEEYIK 397
>KPEL_DROME (Q05652) Probable serine/threonine-protein kinase pelle (EC| 2.7.11.1) Length = 501 Score = 97.8 bits (242), Expect = 2e-20 Identities = 52/140 (37%), Positives = 85/140 (60%), Gaps = 5/140 (3%) Frame = +3 Query: 60 LREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTL----KSHLYGSDMPPL 227 L++ E++ L+ +RH ++++L GY + + LVY+ M+ G+L ++H + +P L Sbjct: 256 LQQSYNELKYLNSIRHDNILALYGYSIKGGKPCLVYQLMKGGSLEARLRAHKAQNPLPAL 315 Query: 228 GWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSKTGPE-L 404 W++R I +G ARG+++ HT +IH D+K ANILLD+ L K+ DFGL + GP+ L Sbjct: 316 TWQQRFSISLGTARGIYFLHTARGTPLIHGDIKPANILLDQCLQPKIGDFGLVREGPKSL 375 Query: 405 DQTHVSTAVKGSFGYLDPEY 464 D V G+ YL PE+ Sbjct: 376 DAVVEVNKVFGTKIYLPPEF 395
>RPK1_IPONI (P93194) Receptor-like protein kinase precursor (EC 2.7.11.1)| Length = 1109 Score = 95.9 bits (237), Expect = 6e-20 Identities = 50/129 (38%), Positives = 76/129 (58%), Gaps = 1/129 (0%) Frame = +3 Query: 78 EIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYGSDMP-PLGWKKRVEIC 254 EIE + +RHR+L+ L + + +++Y YME G+L L+ ++ P PL W R I Sbjct: 861 EIETIGKVRHRNLIKLEEFWLRKEYGLILYTYMENGSLHDILHETNPPKPLDWSTRHNIA 920 Query: 255 IGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSKTGPELDQTHVSTAVK 434 +G A GL Y H +I+HRD+K NILLD +L +SDFG++K + + S V+ Sbjct: 921 VGTAHGLAYLHFDCDPAIVHRDIKPMNILLDSDLEPHISDFGIAKLLDQSATSIPSNTVQ 980 Query: 435 GSFGYLDPE 461 G+ GY+ PE Sbjct: 981 GTIGYMAPE 989
>YR831_MIMIV (Q7T6Y2) Putative serine/threonine-protein kinase/receptor R831| precursor (EC 2.7.11.1) Length = 1624 Score = 88.2 bits (217), Expect = 1e-17 Identities = 50/151 (33%), Positives = 86/151 (56%), Gaps = 2/151 (1%) Frame = +3 Query: 15 TKVAVKRGNQK--SHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGT 188 T+VAVK + K S R F E+++++ LRH ++V + + M +V E+M G+ Sbjct: 808 TEVAVKLISSKHVSKDMERSFFEEVKIMTSLRHPNVVLFMAASTKSPNMCIVMEFMSLGS 867 Query: 189 LKSHLYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKV 368 L L +P + + ++++ A++G+H+ H+ I+HRD+KS N+LLD KV Sbjct: 868 LYDLLGNELIPEIPYALKIKMAYQASKGMHFLHSS---GIVHRDLKSLNLLLDSKWNVKV 924 Query: 369 SDFGLSKTGPELDQTHVSTAVKGSFGYLDPE 461 SDFGL+K ELD+ + + G+ ++ PE Sbjct: 925 SDFGLTKVKSELDKKKTNDNIIGTIHWIAPE 955 Score = 84.0 bits (206), Expect = 2e-16 Identities = 47/125 (37%), Positives = 76/125 (60%), Gaps = 2/125 (1%) Frame = +3 Query: 21 VAVKR--GNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLK 194 VAVK+ + S L EFR E+ LS L+H ++V+ IG C ++ + +V EYM G L+ Sbjct: 1388 VAVKKFVKQKLSETQLLEFRAEMAFLSELKHSNIVTFIGACIKKPNICIVTEYMRMGNLR 1447 Query: 195 SHLYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSD 374 L D+ + + ++++ GAA G+ Y H+ I+HRD+K ANIL+DE+ K++D Sbjct: 1448 DVLKNPDI-KITFANKLKLLYGAAMGIDYLHSS-NPMIVHRDIKPANILVDEHFNVKIAD 1505 Query: 375 FGLSK 389 FG ++ Sbjct: 1506 FGFAR 1510
>IRAK3_MOUSE (Q8K4B2) Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1)| (IRAK-3) (IL-1 receptor-associated kinase M) (IRAK-M) Length = 609 Score = 87.0 bits (214), Expect = 3e-17 Identities = 54/159 (33%), Positives = 82/159 (51%), Gaps = 9/159 (5%) Frame = +3 Query: 24 AVKRGNQKSHQGLRE----FRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTL 191 AVK Q+ L++ F +E+E+L RH H++ L Y E ++ LVY YM GTL Sbjct: 203 AVKLFKQEKKMQLKKHWKRFLSELEVLLLFRHPHILELAAYFTETEKLCLVYPYMSNGTL 262 Query: 192 KSHLYGSD-MPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKV 368 L ++ PL W R+ + IG A+ + Y H ++I +V SANILLD+ L K+ Sbjct: 263 FDRLQCTNGTTPLSWHVRISVLIGIAKAIQYLHNTQPCAVICGNVSSANILLDDQLQPKL 322 Query: 369 SDFGLSKTGPELDQTHVSTAVKGS----FGYLDPEYYRR 473 +DF + P L+Q + + G Y+ EY R+ Sbjct: 323 TDFAAAHFRPNLEQQSSTINMTGGGRKHLWYMPEEYIRQ 361
>NTRK2_RAT (Q63604) BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B) Length = 821 Score = 79.3 bits (194), Expect = 6e-15 Identities = 53/163 (32%), Positives = 79/163 (48%), Gaps = 11/163 (6%) Frame = +3 Query: 6 QDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKG 185 QD VAVK S ++F E ELL+ L+H H+V G C E + +I+V+EYM+ G Sbjct: 563 QDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHG 622 Query: 186 TLKSHL--YGSDM-------PP--LGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSA 332 L L +G D PP L + + I A G+ Y ++ +HRD+ + Sbjct: 623 DLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYL---ASQHFVHRDLATR 679 Query: 333 NILLDENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPE 461 N L+ ENL+ K+ DFG+S+ D V ++ PE Sbjct: 680 NCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPE 722
>NTRK2_MOUSE (P15209) BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B) Length = 821 Score = 79.3 bits (194), Expect = 6e-15 Identities = 53/163 (32%), Positives = 79/163 (48%), Gaps = 11/163 (6%) Frame = +3 Query: 6 QDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKG 185 QD VAVK S ++F E ELL+ L+H H+V G C E + +I+V+EYM+ G Sbjct: 563 QDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHG 622 Query: 186 TLKSHL--YGSDM-------PP--LGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSA 332 L L +G D PP L + + I A G+ Y ++ +HRD+ + Sbjct: 623 DLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYL---ASQHFVHRDLATR 679 Query: 333 NILLDENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPE 461 N L+ ENL+ K+ DFG+S+ D V ++ PE Sbjct: 680 NCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPE 722
>NTRK2_HUMAN (Q16620) BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB) (Trk-B) Length = 822 Score = 79.3 bits (194), Expect = 6e-15 Identities = 53/163 (32%), Positives = 79/163 (48%), Gaps = 11/163 (6%) Frame = +3 Query: 6 QDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKG 185 QD VAVK S ++F E ELL+ L+H H+V G C E + +I+V+EYM+ G Sbjct: 564 QDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHG 623 Query: 186 TLKSHL--YGSDM-------PP--LGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSA 332 L L +G D PP L + + I A G+ Y ++ +HRD+ + Sbjct: 624 DLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYL---ASQHFVHRDLATR 680 Query: 333 NILLDENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPE 461 N L+ ENL+ K+ DFG+S+ D V ++ PE Sbjct: 681 NCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPE 723
>TMKL1_ARATH (P33543) Putative kinase-like protein TMKL1 precursor| Length = 674 Score = 79.0 bits (193), Expect = 7e-15 Identities = 47/133 (35%), Positives = 75/133 (56%), Gaps = 3/133 (2%) Frame = +3 Query: 81 IELLSGLRHRHLVSLIG-YCDEQNEMILVYEYMEKGTLKSHLYGSD--MPPLGWKKRVEI 251 I L +RH +LV L Y ++ E +L+Y+Y+ +L L+ S P L W +R +I Sbjct: 418 IRQLGRIRHENLVPLRAFYQGKRGEKLLIYDYLPNISLHDLLHESKPRKPALNWARRHKI 477 Query: 252 CIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSKTGPELDQTHVSTAV 431 +G ARGL Y HTG IIH +++S N+L+D+ A++++FGL K + + + Sbjct: 478 ALGIARGLAYLHTGQEVPIIHGNIRSKNVLVDDFFFARLTEFGLDKIMVQAVADEIVSQA 537 Query: 432 KGSFGYLDPEYYR 470 K S GY PE ++ Sbjct: 538 K-SDGYKAPELHK 549
>NTRK2_CHICK (Q91987) BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (Trk-B) Length = 818 Score = 77.4 bits (189), Expect = 2e-14 Identities = 50/163 (30%), Positives = 76/163 (46%), Gaps = 11/163 (6%) Frame = +3 Query: 6 QDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKG 185 QD VAVK S ++F E ELL+ L+H H+V G C E + +I+V+EYM+ G Sbjct: 560 QDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHG 619 Query: 186 TLKSHL-----------YGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSA 332 L L G+ L + + I A G+ Y ++ +HRD+ + Sbjct: 620 DLNKFLRAHGPDAVLMAEGNRPAELTQSQMLHIAQQIAAGMVYL---ASQHFVHRDLATR 676 Query: 333 NILLDENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPE 461 N L+ ENL+ K+ DFG+S+ D V ++ PE Sbjct: 677 NCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPE 719
>IRAK3_HUMAN (Q9Y616) Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1)| (IRAK-3) (IL-1 receptor-associated kinase M) (IRAK-M) Length = 596 Score = 77.0 bits (188), Expect = 3e-14 Identities = 44/142 (30%), Positives = 72/142 (50%), Gaps = 5/142 (3%) Frame = +3 Query: 63 REFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYG-SDMPPLGWKK 239 + F +E+E+L H +++ L Y E + L+Y YM GTL L D PL W Sbjct: 207 KRFLSELEVLLLFHHPNILELAAYFTETEKFCLIYPYMRNGTLFDRLQCVGDTAPLPWHI 266 Query: 240 RVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSKTGPELDQ--- 410 R+ I IG ++ +HY H S+I + SANILLD+ K++DF ++ L+ Sbjct: 267 RIGILIGISKAIHYLHNVQPCSVICGSISSANILLDDQFQPKLTDFAMAHFRSHLEHQSC 326 Query: 411 -THVSTAVKGSFGYLDPEYYRR 473 +++++ Y+ EY R+ Sbjct: 327 TINMTSSSSKHLWYMPEEYIRQ 348
>NTRK1_RAT (P35739) High affinity nerve growth factor receptor precursor (EC| 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (p140-TrkA) (Slow nerve growth factor receptor) (Trk-A) Length = 799 Score = 75.9 bits (185), Expect = 6e-14 Identities = 52/173 (30%), Positives = 81/173 (46%), Gaps = 15/173 (8%) Frame = +3 Query: 6 QDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKG 185 QD VAVK + S ++F E ELL+ L+H+H+V G C E +++V+EYM G Sbjct: 539 QDKMLVAVKALKETSENARQDFHREAELLTMLQHQHIVRFFGVCTEGGPLLMVFEYMRHG 598 Query: 186 TLKSHL--YGSDMP-----------PLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVK 326 L L +G D PLG + + + A G+ Y + +HRD+ Sbjct: 599 DLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYL---ASLHFVHRDLA 655 Query: 327 SANILLDENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPE--YYRRQS 479 + N L+ + L+ K+ DFG+S+ D V ++ PE YR+ S Sbjct: 656 TRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFS 708
>NTRK1_HUMAN (P04629) High affinity nerve growth factor receptor precursor (EC| 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1 transforming tyrosine kinase protein) (p140-TrkA) (Trk-A) Length = 796 Score = 75.5 bits (184), Expect = 8e-14 Identities = 49/165 (29%), Positives = 77/165 (46%), Gaps = 13/165 (7%) Frame = +3 Query: 6 QDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKG 185 QD VAVK + S ++F+ E ELL+ L+H+H+V G C E +++V+EYM G Sbjct: 536 QDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHG 595 Query: 186 TLKSHL--YGSDMP-----------PLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVK 326 L L +G D PLG + + + A G+ Y +HRD+ Sbjct: 596 DLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYL---AGLHFVHRDLA 652 Query: 327 SANILLDENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPE 461 + N L+ + L+ K+ DFG+S+ D V ++ PE Sbjct: 653 TRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPE 697
>BRAF1_CHICK (Q04982) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Rmil serine/threonine-protein kinase) (c-Rmil) Length = 806 Score = 75.1 bits (183), Expect = 1e-13 Identities = 52/154 (33%), Positives = 82/154 (53%), Gaps = 2/154 (1%) Frame = +3 Query: 21 VAVKRGN--QKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLK 194 VAVK N + Q L+ F+ E+ +L RH +++ +GY + ++ +V ++ E +L Sbjct: 520 VAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKP-QLAIVTQWCEGSSLY 578 Query: 195 SHLYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSD 374 HL+ + K ++I A+G+ Y H AKSIIHRD+KS NI L E+L K+ D Sbjct: 579 HHLHIIETK-FEMIKLIDIARQTAQGMDYLH---AKSIIHRDLKSNNIFLHEDLTVKIGD 634 Query: 375 FGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQ 476 FGL+ +H + GS ++ PE R Q Sbjct: 635 FGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQ 668
>BRAF1_HUMAN (P15056) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (p94) (v-Raf murine sarcoma viral oncogene homolog B1) Length = 766 Score = 75.1 bits (183), Expect = 1e-13 Identities = 52/154 (33%), Positives = 82/154 (53%), Gaps = 2/154 (1%) Frame = +3 Query: 21 VAVKRGN--QKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLK 194 VAVK N + Q L+ F+ E+ +L RH +++ +GY + ++ +V ++ E +L Sbjct: 480 VAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKP-QLAIVTQWCEGSSLY 538 Query: 195 SHLYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSD 374 HL+ + K ++I A+G+ Y H AKSIIHRD+KS NI L E+L K+ D Sbjct: 539 HHLHIIETK-FEMIKLIDIARQTAQGMDYLH---AKSIIHRDLKSNNIFLHEDLTVKIGD 594 Query: 375 FGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQ 476 FGL+ +H + GS ++ PE R Q Sbjct: 595 FGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQ 628
>BRAF1_COTJA (P34908) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (RMIL serine/threonine-protein kinase) (c-RMIL) Length = 807 Score = 75.1 bits (183), Expect = 1e-13 Identities = 52/154 (33%), Positives = 82/154 (53%), Gaps = 2/154 (1%) Frame = +3 Query: 21 VAVKRGN--QKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLK 194 VAVK N + Q L+ F+ E+ +L RH +++ +GY + ++ +V ++ E +L Sbjct: 520 VAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKP-QLAIVTQWCEGSSLY 578 Query: 195 SHLYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSD 374 HL+ + K ++I A+G+ Y H AKSIIHRD+KS NI L E+L K+ D Sbjct: 579 HHLHIIETK-FEMIKLIDIARQTAQGMDYLH---AKSIIHRDLKSNNIFLHEDLTVKIGD 634 Query: 375 FGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQ 476 FGL+ +H + GS ++ PE R Q Sbjct: 635 FGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQ 668
>RMIL_AVEVR (P27966) Serine/threonine-protein kinase transforming protein Rmil| (EC 2.7.11.1) Length = 450 Score = 75.1 bits (183), Expect = 1e-13 Identities = 52/154 (33%), Positives = 82/154 (53%), Gaps = 2/154 (1%) Frame = +3 Query: 21 VAVKRGN--QKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLK 194 VAVK N + Q L+ F+ E+ +L RH +++ +GY + ++ +V ++ E +L Sbjct: 106 VAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKP-QLAIVTQWCEGSSLY 164 Query: 195 SHLYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSD 374 HL+ + K ++I A+G+ Y H AKSIIHRD+KS NI L E+L K+ D Sbjct: 165 HHLHIIETK-FEMIKLIDIARQTAQGMDYLH---AKSIIHRDLKSNNIFLHEDLTVKIGD 220 Query: 375 FGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQ 476 FGL+ +H + GS ++ PE R Q Sbjct: 221 FGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQ 254
>BRAF1_MOUSE (P28028) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Fragment) Length = 328 Score = 75.1 bits (183), Expect = 1e-13 Identities = 52/154 (33%), Positives = 82/154 (53%), Gaps = 2/154 (1%) Frame = +3 Query: 21 VAVKRGN--QKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLK 194 VAVK N + Q L+ F+ E+ +L RH +++ +GY + ++ +V ++ E +L Sbjct: 42 VAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKP-QLAIVTQWCEGSSLY 100 Query: 195 SHLYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSD 374 HL+ + K ++I A+G+ Y H AKSIIHRD+KS NI L E+L K+ D Sbjct: 101 HHLHIIETK-FEMIKLIDIARQTAQGMDYLH---AKSIIHRDLKSNNIFLHEDLTVKIGD 156 Query: 375 FGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQ 476 FGL+ +H + GS ++ PE R Q Sbjct: 157 FGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQ 190
>RMIL_AVII1 (P10533) Serine/threonine-protein kinase transforming protein Rmil| (EC 2.7.11.1) Length = 367 Score = 75.1 bits (183), Expect = 1e-13 Identities = 52/154 (33%), Positives = 82/154 (53%), Gaps = 2/154 (1%) Frame = +3 Query: 21 VAVKRGN--QKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLK 194 VAVK N + Q L+ F+ E+ +L RH +++ +GY + ++ +V ++ E +L Sbjct: 90 VAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKP-QLAIVTQWCEGSSLY 148 Query: 195 SHLYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSD 374 HL+ + K ++I A+G+ Y H AKSIIHRD+KS NI L E+L K+ D Sbjct: 149 HHLHIIETK-FEMIKLIDIARQTAQGMDYLH---AKSIIHRDLKSNNIFLHEDLTVKIGD 204 Query: 375 FGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQ 476 FGL+ +H + GS ++ PE R Q Sbjct: 205 FGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQ 238
>TESK1_HUMAN (Q15569) Dual specificity testis-specific protein kinase 1 (EC| 2.7.12.1) (Testicular protein kinase 1) Length = 626 Score = 74.7 bits (182), Expect = 1e-13 Identities = 48/136 (35%), Positives = 72/136 (52%), Gaps = 5/136 (3%) Frame = +3 Query: 78 EIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYGSDMPPLGWKKRVEICI 257 E++L++ LRH +++ +G C Q ++ + EYM GTL+ L S PL W R+ + + Sbjct: 100 EVQLMNRLRHPNILRFMGVCVHQGQLHALTEYMNGGTLEQLL--SSPEPLSWPVRLHLAL 157 Query: 258 GAARGLHYQHTGFAKSIIHRDVKSANILL---DENLMAKVSDFGLSKTGPELDQ--THVS 422 ARGL Y H +K + HRD+ S N L+ D A V DFGL++ P + Sbjct: 158 DIARGLRYLH---SKGVFHRDLTSKNCLVRREDRGFTAVVGDFGLAEKIPVYREGARKEP 214 Query: 423 TAVKGSFGYLDPEYYR 470 AV GS ++ PE R Sbjct: 215 LAVVGSPYWMAPEVLR 230
>TESK1_MOUSE (O70146) Dual specificity testis-specific protein kinase 1 (EC| 2.7.12.1) (Testicular protein kinase 1) Length = 627 Score = 74.3 bits (181), Expect = 2e-13 Identities = 48/136 (35%), Positives = 72/136 (52%), Gaps = 5/136 (3%) Frame = +3 Query: 78 EIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYGSDMPPLGWKKRVEICI 257 E++L++ LRH +++ +G C Q ++ + EYM GTL+ L S PL W R+ + + Sbjct: 95 EVQLMNRLRHPNILRFMGVCVHQGQLHALTEYMNGGTLEQLL--SSPEPLSWPVRLHLAL 152 Query: 258 GAARGLHYQHTGFAKSIIHRDVKSANILL---DENLMAKVSDFGLSKTGPELDQ--THVS 422 A+GL Y H AK + HRD+ S N L+ D A V DFGL++ P + Sbjct: 153 DIAQGLRYLH---AKGVFHRDLTSKNCLVRREDRGFTAVVGDFGLAEKIPVYREGTRKEP 209 Query: 423 TAVKGSFGYLDPEYYR 470 AV GS ++ PE R Sbjct: 210 LAVVGSPYWMAPEVLR 225
>NTRK3_RAT (Q03351) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C) Length = 864 Score = 73.9 bits (180), Expect = 2e-13 Identities = 48/160 (30%), Positives = 76/160 (47%), Gaps = 14/160 (8%) Frame = +3 Query: 6 QDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKG 185 +D VAVK + ++F+ E ELL+ L+H H+V G C + + +I+V+EYM+ G Sbjct: 564 KDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHG 623 Query: 186 TLKSHL--YGSD------------MPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDV 323 L L +G D LG + + I A G+ Y ++ +HRD+ Sbjct: 624 DLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYL---ASQHFVHRDL 680 Query: 324 KSANILLDENLMAKVSDFGLSKTGPELDQTHVSTAVKGSF 443 + N L+ NL+ K+ DFG+S+ D KG F Sbjct: 681 ATRNCLVGANLLVKIGDFGMSRDVYSTDYYREGPYQKGPF 720
>TESK1_RAT (Q63572) Dual specificity testis-specific protein kinase 1 (EC| 2.7.12.1) (Testicular protein kinase 1) Length = 628 Score = 73.6 bits (179), Expect = 3e-13 Identities = 48/136 (35%), Positives = 72/136 (52%), Gaps = 5/136 (3%) Frame = +3 Query: 78 EIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYGSDMPPLGWKKRVEICI 257 E++L++ LRH +++ +G C Q ++ + EYM GTL+ L S PL W R+ + + Sbjct: 95 EVQLMNRLRHPNILRFMGVCVHQGQLHALTEYMNGGTLEQLL--SSPEPLSWPVRLHLAL 152 Query: 258 GAARGLHYQHTGFAKSIIHRDVKSANILL---DENLMAKVSDFGLSKTGPELDQ--THVS 422 A+GL Y H AK + HRD+ S N L+ D A V DFGL++ P + Sbjct: 153 DIAQGLRYLH---AKGVFHRDLTSKNCLVRREDGGFTAVVGDFGLAEKIPVYREGARKEP 209 Query: 423 TAVKGSFGYLDPEYYR 470 AV GS ++ PE R Sbjct: 210 LAVVGSPYWMAPEVLR 225
>NTRK3_PANTR (Q5IS37) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) Length = 825 Score = 73.2 bits (178), Expect = 4e-13 Identities = 48/166 (28%), Positives = 78/166 (46%), Gaps = 14/166 (8%) Frame = +3 Query: 6 QDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKG 185 +D VAVK + ++F+ E ELL+ L+H H+V G C + + +I+V+EYM+ G Sbjct: 564 KDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHG 623 Query: 186 TLKSHL--YGSD------------MPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDV 323 L L +G D LG + + I A G+ Y ++ +HRD+ Sbjct: 624 DLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYL---ASQHFVHRDL 680 Query: 324 KSANILLDENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPE 461 + N L+ NL+ K+ DFG+S+ D V ++ PE Sbjct: 681 ATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPE 726
>NTRK3_MACFA (Q5IFJ9) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) Length = 825 Score = 73.2 bits (178), Expect = 4e-13 Identities = 48/166 (28%), Positives = 78/166 (46%), Gaps = 14/166 (8%) Frame = +3 Query: 6 QDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKG 185 +D VAVK + ++F+ E ELL+ L+H H+V G C + + +I+V+EYM+ G Sbjct: 564 KDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHG 623 Query: 186 TLKSHL--YGSD------------MPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDV 323 L L +G D LG + + I A G+ Y ++ +HRD+ Sbjct: 624 DLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYL---ASQHFVHRDL 680 Query: 324 KSANILLDENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPE 461 + N L+ NL+ K+ DFG+S+ D V ++ PE Sbjct: 681 ATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPE 726
>HT1_ARATH (Q2MHE4) Serine/threonine-protein kinase HT1 (EC 2.7.11.1) (High| leaf temperature protein 1) Length = 390 Score = 73.2 bits (178), Expect = 4e-13 Identities = 36/108 (33%), Positives = 65/108 (60%) Frame = +3 Query: 63 REFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYGSDMPPLGWKKR 242 ++F++E+ LLS L H ++V I C + ++ EYM +G L+ +L + L + Sbjct: 130 QQFKSEVALLSRLFHPNIVQFIAACKKPPVYCIITEYMSQGNLRMYLNKKEPYSLSIETV 189 Query: 243 VEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLS 386 + + + +RG+ Y H ++ +IHRD+KS N+LL++ + KV+DFG S Sbjct: 190 LRLALDISRGMEYLH---SQGVIHRDLKSNNLLLNDEMRVKVADFGTS 234
>RIPK2_MOUSE (P58801) Receptor-interacting serine/threonine-protein kinase 2 (EC| 2.7.11.1) Length = 539 Score = 72.8 bits (177), Expect = 5e-13 Identities = 43/134 (32%), Positives = 70/134 (52%), Gaps = 4/134 (2%) Frame = +3 Query: 78 EIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYG-SDMPPLGWKKRVEIC 254 E E+L R +++ ++G C+E + +V EYM G+L L+ ++ P + W R I Sbjct: 66 EAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDIAWPLRFRIL 125 Query: 255 IGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSK---TGPELDQTHVST 425 A G++Y H ++H D+K+ NILLD K++DFGLSK +++ S Sbjct: 126 HEIALGVNYLHN-MNPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSYKSA 184 Query: 426 AVKGSFGYLDPEYY 467 G+ Y+ PE Y Sbjct: 185 PEGGTIIYMPPENY 198
>NUAK1_HUMAN (O60285) NUAK family, SNF1-like kinase 1 (EC 2.7.11.1)| (AMPK-related protein kinase 5) Length = 661 Score = 72.8 bits (177), Expect = 5e-13 Identities = 37/121 (30%), Positives = 67/121 (55%) Frame = +3 Query: 24 AVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHL 203 ++++ K Q + R EIE++S L H H++S+ + +++++++ EY KG L ++ Sbjct: 85 SIRKDKIKDEQDMVHIRREIEIMSSLNHPHIISIYEVFENKDKIVIIMEYASKGELYDYI 144 Query: 204 YGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDFGL 383 S+ L ++ +HY H ++HRD+K NILLD+N K++DFGL Sbjct: 145 --SERRRLSERETRHFFRQIVSAVHYCH---KNGVVHRDLKLENILLDDNCNIKIADFGL 199 Query: 384 S 386 S Sbjct: 200 S 200
>KYK1_DICDI (P18160) Non-receptor tyrosine kinase spore lysis A (EC 2.7.10.2)| (Tyrosine-protein kinase 1) Length = 1584 Score = 72.8 bits (177), Expect = 5e-13 Identities = 56/174 (32%), Positives = 86/174 (49%), Gaps = 19/174 (10%) Frame = +3 Query: 15 TKVAVK---RGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNE--MILVYEYME 179 T VA+K R K+ L F+ E+ +LS LRH ++V +G C E +V E+M Sbjct: 1311 TDVAIKIIYRDQFKTKSSLVMFQNEVGILSKLRHPNVVQFLGACTAGGEDHHCIVTEWMG 1370 Query: 180 KGTLKSHLYGS-DMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDEN- 353 G+L+ L ++ R+++ + A+G++Y H G+ I+HRD+ S NILLD N Sbjct: 1371 GGSLRQFLTDHFNLLEQNPHIRLKLALDIAKGMNYLH-GWTPPILHRDLSSRNILLDHNI 1429 Query: 354 ------------LMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQS 479 + K+SDFGLS+ E Q T G Y+ PE ++ S Sbjct: 1430 DPKNPVVSSRQDIKCKISDFGLSRLKKE--QASQMTQSVGCIPYMAPEVFKGDS 1481
>RIPK2_HUMAN (O43353) Receptor-interacting serine/threonine-protein kinase 2 (EC| 2.7.11.1) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (CARD-containing interleukin-1 beta-converting enzyme-associated kinase) (CARD-containi Length = 540 Score = 72.8 bits (177), Expect = 5e-13 Identities = 45/134 (33%), Positives = 71/134 (52%), Gaps = 4/134 (2%) Frame = +3 Query: 78 EIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYG-SDMPPLGWKKRVEIC 254 E E+L R +++ ++G C+E + +V EYM G+L L+ ++ P + W R I Sbjct: 66 EAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRIL 125 Query: 255 IGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSK-TGPELDQTHVSTAV 431 A G++Y H ++H D+K+ NILLD K++DFGLSK L Q+ S + Sbjct: 126 HEIALGVNYLHN-MTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSA 184 Query: 432 K--GSFGYLDPEYY 467 G+ Y+ PE Y Sbjct: 185 PEGGTIIYMPPENY 198
>NTRK3_CHICK (Q91044) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (Trk-C) Length = 827 Score = 72.8 bits (177), Expect = 5e-13 Identities = 48/165 (29%), Positives = 77/165 (46%), Gaps = 14/165 (8%) Frame = +3 Query: 9 DSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGT 188 D VAVK + ++F+ E ELL+ L+H H+V G C + + +I+V+EYM+ G Sbjct: 567 DKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGD 626 Query: 189 LKSHL--YGSD------------MPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVK 326 L L +G D LG + + I A G+ Y ++ +HRD+ Sbjct: 627 LNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYL---ASQHFVHRDLA 683 Query: 327 SANILLDENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPE 461 + N L+ NL+ K+ DFG+S+ D V ++ PE Sbjct: 684 TRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPE 728
>NTRK3_HUMAN (Q16288) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C) Length = 839 Score = 72.4 bits (176), Expect = 7e-13 Identities = 44/142 (30%), Positives = 72/142 (50%), Gaps = 14/142 (9%) Frame = +3 Query: 6 QDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKG 185 +D VAVK + ++F+ E ELL+ L+H H+V G C + + +I+V+EYM+ G Sbjct: 564 KDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHG 623 Query: 186 TLKSHL--YGSD------------MPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDV 323 L L +G D LG + + I A G+ Y ++ +HRD+ Sbjct: 624 DLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYL---ASQHFVHRDL 680 Query: 324 KSANILLDENLMAKVSDFGLSK 389 + N L+ NL+ K+ DFG+S+ Sbjct: 681 ATRNCLVGANLLVKIGDFGMSR 702
>JAK2_MOUSE (Q62120) Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2)| (JAK-2) Length = 1129 Score = 72.0 bits (175), Expect = 9e-13 Identities = 46/137 (33%), Positives = 74/137 (54%), Gaps = 4/137 (2%) Frame = +3 Query: 3 LQDSTK--VAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDE--QNEMILVYE 170 LQD+T VAVK+ + + LR+F EIE+L L+H ++V G C + + L+ E Sbjct: 871 LQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLRLIME 930 Query: 171 YMEKGTLKSHLYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDE 350 Y+ G+L+ +L + KK ++ +G+ Y T K IHRD+ + NIL++ Sbjct: 931 YLPYGSLRDYLQ-KHKERIDHKKLLQYTSQICKGMEYLGT---KRYIHRDLATRNILVEN 986 Query: 351 NLMAKVSDFGLSKTGPE 401 K+ DFGL+K P+ Sbjct: 987 ENRVKIGDFGLTKVLPQ 1003 Score = 43.1 bits (100), Expect = 4e-04 Identities = 42/127 (33%), Positives = 65/127 (51%), Gaps = 11/127 (8%) Frame = +3 Query: 45 KSHQGLRE-FRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHL-YGSDM 218 K+H+ E F ++S L H+HLV G C E ILV E+++ G+L ++L + Sbjct: 585 KAHRNYSESFFEAASMMSQLSHKHLVLNYGVCVCGEENILVQEFVKFGSLDTYLKKNKNS 644 Query: 219 PPLGWKKRVEICIGAARGLHY-QHTGFAKSIIHRDVKSANILL--DENL------MAKVS 371 + WK +G A+ L + H KS+IH +V + NILL +E+ K+S Sbjct: 645 INILWK------LGVAKQLAWAMHFLEEKSLIHGNVCAKNILLIREEDRRTGNPPFIKLS 698 Query: 372 DFGLSKT 392 D G+S T Sbjct: 699 DPGISIT 705
>RAF1_XENLA (P09560) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (C-RAF) Length = 638 Score = 72.0 bits (175), Expect = 9e-13 Identities = 47/152 (30%), Positives = 78/152 (51%) Frame = +3 Query: 21 VAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSH 200 V + + + + L+ FR E+ +L RH +++ +GY + N + +V ++ E +L H Sbjct: 365 VKILKVTDPTPEQLQAFRNEVAVLRKTRHVNILLFMGYMTKDN-LAIVTQWCEGSSLYYH 423 Query: 201 LYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDFG 380 L+ D + ++I A+G+ Y H AK+IIHRD+KS NI L E L K+ DFG Sbjct: 424 LHVLDTK-FQMFQLIDIARQTAQGMDYLH---AKNIIHRDMKSNNIFLHEGLTVKIGDFG 479 Query: 381 LSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQ 476 L+ + + GS ++ PE R Q Sbjct: 480 LATVKTRWSGSQQVEQLTGSILWMAPEVIRMQ 511
>JAK2_RAT (Q62689) Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2)| (JAK-2) Length = 1132 Score = 72.0 bits (175), Expect = 9e-13 Identities = 46/137 (33%), Positives = 74/137 (54%), Gaps = 4/137 (2%) Frame = +3 Query: 3 LQDSTK--VAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDE--QNEMILVYE 170 LQD+T VAVK+ + + LR+F EIE+L L+H ++V G C + + L+ E Sbjct: 871 LQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLRLIME 930 Query: 171 YMEKGTLKSHLYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDE 350 Y+ G+L+ +L + KK ++ +G+ Y T K IHRD+ + NIL++ Sbjct: 931 YLPYGSLRDYLQ-KHKERIDHKKLLQYTSQICKGMEYLGT---KRYIHRDLATRNILVEN 986 Query: 351 NLMAKVSDFGLSKTGPE 401 K+ DFGL+K P+ Sbjct: 987 ENRVKIGDFGLTKVLPQ 1003 Score = 43.1 bits (100), Expect = 4e-04 Identities = 42/127 (33%), Positives = 65/127 (51%), Gaps = 11/127 (8%) Frame = +3 Query: 45 KSHQGLRE-FRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHL-YGSDM 218 K+H+ E F ++S L H+HLV G C E ILV E+++ G+L ++L + Sbjct: 585 KAHRNYSESFFEAASMMSQLSHKHLVLNYGVCVCGEENILVQEFVKFGSLDTYLKKNKNS 644 Query: 219 PPLGWKKRVEICIGAARGLHY-QHTGFAKSIIHRDVKSANILL--DENL------MAKVS 371 + WK +G A+ L + H KS+IH +V + NILL +E+ K+S Sbjct: 645 INILWK------LGVAKQLAWAMHFLEEKSLIHGNVCAKNILLIREEDRKTGNPPFIKLS 698 Query: 372 DFGLSKT 392 D G+S T Sbjct: 699 DPGISIT 705
>FUSED_DROME (P23647) Serine/threonine-protein kinase fused (EC 2.7.11.1)| Length = 805 Score = 72.0 bits (175), Expect = 9e-13 Identities = 47/153 (30%), Positives = 82/153 (53%) Frame = +3 Query: 18 KVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKS 197 KV KRG ++ + L+ R E ++ + L+H H++ +I + + ++ +V E+ + Sbjct: 33 KVISKRG--RATKELKNLRRECDIQARLKHPHVIEMIESFESKTDLFVVTEF---ALMDL 87 Query: 198 HLYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDF 377 H Y S +G + + L+Y H+ I+HRD+K N+LLD+N+ AK+ DF Sbjct: 88 HRYLSYNGAMGEEPARRVTGHLVSALYYLHSN---RILHRDLKPQNVLLDKNMHAKLCDF 144 Query: 378 GLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQ 476 GL++ THV T++KG+ Y+ PE Q Sbjct: 145 GLARN--MTLGTHVLTSIKGTPLYMAPELLAEQ 175
>SRC64_DROME (P00528) Tyrosine-protein kinase Src64B (EC 2.7.10.2) (Dsrc64)| Length = 552 Score = 71.6 bits (174), Expect = 1e-12 Identities = 42/128 (32%), Positives = 68/128 (53%) Frame = +3 Query: 6 QDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKG 185 ++S VAVK + + F E ++ RH LV+L C ++ + +V EYM KG Sbjct: 304 RNSIDVAVKTLREGT-MSTAAFLQEAAIMKKFRHNRLVALYAVCSQEEPIYIVQEYMSKG 362 Query: 186 TLKSHLYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAK 365 +L L D L ++ + I A G+ Y +K +IHRD+ + N+L+ EN +AK Sbjct: 363 SLLDFLREGDGRYLHFEDLIYIATQVASGMEYLE---SKQLIHRDLAARNVLIGENNVAK 419 Query: 366 VSDFGLSK 389 + DFGL++ Sbjct: 420 ICDFGLAR 427
>KRAF1_DROME (P11346) Raf homolog serine/threonine-protein kinase dRAF-1 (EC| 2.7.11.1) (Protein pole-hole) Length = 739 Score = 71.2 bits (173), Expect = 2e-12 Identities = 53/156 (33%), Positives = 81/156 (51%), Gaps = 4/156 (2%) Frame = +3 Query: 21 VAVKRGNQK--SHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLK 194 VAVK N K S L+ F+ E+ +L RH +++ +G C + + +V ++ E +L Sbjct: 452 VAVKTLNVKTPSPAQLQAFKNEVAMLKKTRHCNILLFMG-CVSKPSLAIVTQWCEGSSLY 510 Query: 195 SHLYGSDMPPLGWKKRVEICIG--AARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKV 368 H++ S+ +K I IG A+G+ Y H AK+IIHRD+KS NI L E+L K+ Sbjct: 511 KHVHVSETK---FKLNTLIDIGRQVAQGMDYLH---AKNIIHRDLKSNNIFLHEDLSVKI 564 Query: 369 SDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQ 476 DFGL+ + GS ++ PE R Q Sbjct: 565 GDFGLATAKTRWSGEKQANQPTGSILWMAPEVIRMQ 600
>NTRK3_SAIBB (Q5IS82) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) Length = 825 Score = 71.2 bits (173), Expect = 2e-12 Identities = 47/166 (28%), Positives = 77/166 (46%), Gaps = 14/166 (8%) Frame = +3 Query: 6 QDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKG 185 +D VAVK + ++F+ E ELL+ L+H H+V G C + + +I+V+EYM+ G Sbjct: 564 KDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHG 623 Query: 186 TLKSHL--YGSD------------MPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDV 323 L L +G D LG + + I A G+ Y ++ +HRD+ Sbjct: 624 DLNKFLRAHGPDAMILVDGQPXQAKGELGLSQMLHIASQIASGMVYL---ASQHFVHRDL 680 Query: 324 KSANILLDENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPE 461 + N + NL+ K+ DFG+S+ D V ++ PE Sbjct: 681 ATRNCXVGANLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPE 726
>NTRK3_PIG (P24786) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C) Length = 825 Score = 71.2 bits (173), Expect = 2e-12 Identities = 47/158 (29%), Positives = 80/158 (50%), Gaps = 11/158 (6%) Frame = +3 Query: 21 VAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSH 200 VAVK + ++F+ E ELL+ L+H H+V G C + + +I+V+EYM+ G L Sbjct: 569 VAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKF 628 Query: 201 L--YGSDMPPL--GWKKRVEICIGAARGLHYQH---TGF----AKSIIHRDVKSANILLD 347 L +G D L G ++ + +G ++ LH +G ++ +HRD+ + N L+ Sbjct: 629 LRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQICSGMVYLASQHFVHRDLATRNCLVG 688 Query: 348 ENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPE 461 NL+ K+ DFG+S+ D V ++ PE Sbjct: 689 ANLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPE 726
>SPK1_DUGTI (P42687) Tyrosine-protein kinase SPK-1 (EC 2.7.10.2)| Length = 497 Score = 70.9 bits (172), Expect = 2e-12 Identities = 38/118 (32%), Positives = 67/118 (56%), Gaps = 2/118 (1%) Frame = +3 Query: 42 QKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEM--ILVYEYMEKGTLKSHLYGSD 215 Q S +F E +++ LRHR +V L+G C E +M +++ EYM+ G+LK +L D Sbjct: 251 QSSKAEREKFVLEAKIMHKLRHRKIVELLGVCTEPQDMPMLIIVEYMKNGSLKEYLKTPD 310 Query: 216 MPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSK 389 + V + + G+ Y + + ++HRD+++ NIL+ +L KV+DFGL++ Sbjct: 311 GKKTNLNQMVHMMAEISEGMAYLES---EKVVHRDLRADNILVANDLTRKVADFGLTE 365
>NTRK1_CHICK (Q91009) High affinity nerve growth factor receptor precursor (EC| 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (Trk-A) (Fragment) Length = 778 Score = 70.9 bits (172), Expect = 2e-12 Identities = 47/165 (28%), Positives = 75/165 (45%), Gaps = 13/165 (7%) Frame = +3 Query: 6 QDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKG 185 Q+ T VAVK + + +F+ E ELL+ L+H H+V G C E + +I+V+EYM+ G Sbjct: 519 QEKTLVAVKALKEVTENARLDFQREAELLTVLQHEHIVKFYGVCTEGDPLIMVFEYMKHG 578 Query: 186 TLKSHL-------------YGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVK 326 L L G L ++I A G+ Y + +HRD+ Sbjct: 579 DLNRFLRSHGPDAKILDQGQGQPCGQLTLSHMLQIATQIASGMVYL---ASLHFVHRDLA 635 Query: 327 SANILLDENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPE 461 + N L+ +L+ K+ DFG+S+ D V ++ PE Sbjct: 636 TRNCLVGHDLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPE 680
>LIMK2_CHICK (P53666) LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2)| Length = 642 Score = 70.5 bits (171), Expect = 3e-12 Identities = 39/109 (35%), Positives = 63/109 (57%) Frame = +3 Query: 63 REFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYGSDMPPLGWKKR 242 + F TE++++ L H +++ IG + ++ L+ EY+E GTLK L +D P W+++ Sbjct: 371 KTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRNAD--PFPWQQK 428 Query: 243 VEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSK 389 V G A G+ Y H + IIHRD+ S N L+ + V+DFGLS+ Sbjct: 429 VSFAKGIASGMAYLH---SMCIIHRDLNSHNCLIKLDKTVVVADFGLSR 474
>ITK_MOUSE (Q03526) Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2)| (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK) Length = 625 Score = 70.5 bits (171), Expect = 3e-12 Identities = 50/150 (33%), Positives = 75/150 (50%) Frame = +3 Query: 18 KVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKS 197 KVA+K Q+ +F E E++ L H LV L G C EQ + LV+E+ME G L Sbjct: 392 KVAIKT-IQEGAMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSD 450 Query: 198 HLYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDF 377 +L S + + +C+ G+ Y +IHRD+ + N L+ EN + KVSDF Sbjct: 451 YL-RSQRGLFAAETLLGMCLDVCEGMAYLEKA---CVIHRDLAARNCLVGENQVIKVSDF 506 Query: 378 GLSKTGPELDQTHVSTAVKGSFGYLDPEYY 467 G+++ + DQ ST K + PE + Sbjct: 507 GMTRFVLD-DQYTSSTGTKFPVKWASPEVF 535
>RAF_MSV36 (P00532) Serine/threonine-protein kinase transforming protein raf| (EC 2.7.11.1) Length = 323 Score = 70.1 bits (170), Expect = 3e-12 Identities = 45/139 (32%), Positives = 72/139 (51%) Frame = +3 Query: 60 LREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYGSDMPPLGWKK 239 L+ FR E+ +L RH +++ +GY + N + +V ++ E +L HL+ + + Sbjct: 62 LQAFRNEVAVLRKTRHVNILLFMGYMTKDN-LAIVTQWCEGSSLYKHLHVQETK-FQMFQ 119 Query: 240 RVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSKTGPELDQTHV 419 ++I A+G+ Y H AK+IIHRD+KS NI L E L K+ DFGL+ + Sbjct: 120 LIDIARQTAQGMDYLH---AKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQ 176 Query: 420 STAVKGSFGYLDPEYYRRQ 476 GS ++ PE R Q Sbjct: 177 VEQPTGSVLWMAPEVIRMQ 195
>NUAK1_MOUSE (Q641K5) NUAK family, SNF1-like kinase 1 (EC 2.7.11.1)| Length = 658 Score = 70.1 bits (170), Expect = 3e-12 Identities = 36/121 (29%), Positives = 66/121 (54%) Frame = +3 Query: 24 AVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHL 203 ++++ K + R EIE++S L H H++S+ + +++++++ EY KG L ++ Sbjct: 86 SIRKDKIKDELDMVHIRREIEIMSSLNHPHIISIYEVFENKDKIVIIMEYASKGELYDYI 145 Query: 204 YGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDFGL 383 S+ L ++ +HY H ++HRD+K NILLD+N K++DFGL Sbjct: 146 --SERRRLSERETRHFFRQIVSAVHYCH---KNGVVHRDLKLENILLDDNCNIKIADFGL 200 Query: 384 S 386 S Sbjct: 201 S 201
>M3K9_HUMAN (P80192) Mitogen-activated protein kinase kinase kinase 9 (EC| 2.7.11.25) (Mixed lineage kinase 1) Length = 1104 Score = 70.1 bits (170), Expect = 3e-12 Identities = 51/166 (30%), Positives = 87/166 (52%), Gaps = 15/166 (9%) Frame = +3 Query: 18 KVAVKRG----NQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKG 185 +VAVK ++ Q + R E +L + L+H ++++L G C ++ + LV E+ G Sbjct: 167 EVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGG 226 Query: 186 TLKSHLYGSDMPP---LGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDE-- 350 L L G +PP + W ++ ARG++Y H IIHRD+KS+NIL+ + Sbjct: 227 PLNRVLSGKRIPPDILVNWAVQI------ARGMNYLHDEAIVPIIHRDLKSSNILILQKV 280 Query: 351 ------NLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYR 470 N + K++DFGL++ E +T +A G++ ++ PE R Sbjct: 281 ENGDLSNKILKITDFGLAR---EWHRTTKMSAA-GTYAWMAPEVIR 322
>RAF1_RAT (P11345) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 70.1 bits (170), Expect = 3e-12 Identities = 45/139 (32%), Positives = 72/139 (51%) Frame = +3 Query: 60 LREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYGSDMPPLGWKK 239 L+ FR E+ +L RH +++ +GY + N + +V ++ E +L HL+ + + Sbjct: 387 LQAFRNEVAVLRKTRHVNILLFMGYMTKDN-LAIVTQWCEGSSLYKHLHVQETK-FQMFQ 444 Query: 240 RVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSKTGPELDQTHV 419 ++I A+G+ Y H AK+IIHRD+KS NI L E L K+ DFGL+ + Sbjct: 445 LIDIARQTAQGMDYLH---AKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQ 501 Query: 420 STAVKGSFGYLDPEYYRRQ 476 GS ++ PE R Q Sbjct: 502 VEQPTGSVLWMAPEVIRMQ 520
>RAF1_MOUSE (Q99N57) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 70.1 bits (170), Expect = 3e-12 Identities = 45/139 (32%), Positives = 72/139 (51%) Frame = +3 Query: 60 LREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYGSDMPPLGWKK 239 L+ FR E+ +L RH +++ +GY + N + +V ++ E +L HL+ + + Sbjct: 387 LQAFRNEVAVLRKTRHVNILLFMGYMTKDN-LAIVTQWCEGSSLYKHLHVQETK-FQMFQ 444 Query: 240 RVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSKTGPELDQTHV 419 ++I A+G+ Y H AK+IIHRD+KS NI L E L K+ DFGL+ + Sbjct: 445 LIDIARQTAQGMDYLH---AKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQ 501 Query: 420 STAVKGSFGYLDPEYYRRQ 476 GS ++ PE R Q Sbjct: 502 VEQPTGSVLWMAPEVIRMQ 520
>LIMK2_HUMAN (P53671) LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2)| Length = 638 Score = 69.7 bits (169), Expect = 4e-12 Identities = 39/109 (35%), Positives = 62/109 (56%) Frame = +3 Query: 63 REFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYGSDMPPLGWKKR 242 + F TE++++ L H +++ IG + ++ L+ EY+E GTLK L M P W+++ Sbjct: 371 KTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFL--RSMDPFPWQQK 428 Query: 243 VEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSK 389 V G A G+ Y H + IIHRD+ S N L+ + V+DFGLS+ Sbjct: 429 VRFAKGIASGMAYLH---SMCIIHRDLNSHNCLIKLDKTVVVADFGLSR 474
>LYN_HUMAN (P07948) Tyrosine-protein kinase Lyn (EC 2.7.10.2)| Length = 511 Score = 69.7 bits (169), Expect = 4e-12 Identities = 42/127 (33%), Positives = 69/127 (54%) Frame = +3 Query: 9 DSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGT 188 +STKVAVK + ++ F E L+ L+H LV L + + ++ EYM KG+ Sbjct: 267 NSTKVAVKT-LKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGS 325 Query: 189 LKSHLYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKV 368 L L + + K ++ A G+ Y K+ IHRD+++AN+L+ E+LM K+ Sbjct: 326 LLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIER---KNYIHRDLRAANVLVSESLMCKI 382 Query: 369 SDFGLSK 389 +DFGL++ Sbjct: 383 ADFGLAR 389
>RIPK4_HUMAN (P57078) Receptor-interacting serine/threonine-protein kinase 4 (EC| 2.7.11.1) (Ankyrin repeat domain protein 3) (PKC-delta-interacting protein kinase) Length = 832 Score = 69.3 bits (168), Expect = 6e-12 Identities = 51/141 (36%), Positives = 74/141 (52%), Gaps = 3/141 (2%) Frame = +3 Query: 66 EFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYGSDMPPLGWKKRV 245 E E + + + R+++ + G C E + LV EYME G+L+ L PL W R Sbjct: 65 ELLEEAKKMEMAKFRYILPVYGICREP--VGLVMEYMETGSLEKLLASE---PLPWDLRF 119 Query: 246 EICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSKTGPELDQTHVST 425 I A G+++ H A ++H D+K ANILLD + K+SDFGL+K L +H Sbjct: 120 RIIHETAVGMNFLHC-MAPPLLHLDLKPANILLDAHYHVKISDFGLAKCN-GLSHSH-DL 176 Query: 426 AVKGSFG---YLDPEYYRRQS 479 ++ G FG YL PE R +S Sbjct: 177 SMDGLFGTIAYLPPERIREKS 197
>LIMK2_RAT (P53670) LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2)| Length = 638 Score = 69.3 bits (168), Expect = 6e-12 Identities = 39/109 (35%), Positives = 62/109 (56%) Frame = +3 Query: 63 REFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYGSDMPPLGWKKR 242 + F TE++++ L H +++ IG + ++ L+ EY+E GTLK L D P W+++ Sbjct: 371 KTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRNVD--PFPWQQK 428 Query: 243 VEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSK 389 V G A G+ Y H + IIHRD+ S N L+ + V+DFGLS+ Sbjct: 429 VRFAKGIASGMAYLH---SMCIIHRDLNSHNCLIKLDKTVVVADFGLSR 474
>RAF1_CHICK (P05625) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (RAF-1) (C-RAF) (MIL proto-oncogene serine/threonine-protein kinase) (C-MIL) Length = 647 Score = 68.9 bits (167), Expect = 7e-12 Identities = 44/136 (32%), Positives = 70/136 (51%) Frame = +3 Query: 69 FRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYGSDMPPLGWKKRVE 248 FR E+ +L RH +++ +GY + N + +V ++ E +L HL+ + + ++ Sbjct: 390 FRNEVAVLRKTRHVNILLFMGYMTKDN-LAIVTQWCEGSSLYKHLHVQETK-FQMFQLID 447 Query: 249 ICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSKTGPELDQTHVSTA 428 I A+G+ Y H AK+IIHRD+KS NI L E L K+ DFGL+ + Sbjct: 448 IARQTAQGMDYLH---AKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQ 504 Query: 429 VKGSFGYLDPEYYRRQ 476 GS ++ PE R Q Sbjct: 505 PTGSILWMAPEVIRMQ 520
>JAK2_HUMAN (O60674) Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2)| (JAK-2) Length = 1132 Score = 68.9 bits (167), Expect = 7e-12 Identities = 45/137 (32%), Positives = 73/137 (53%), Gaps = 4/137 (2%) Frame = +3 Query: 3 LQDSTK--VAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDE--QNEMILVYE 170 LQD+T VAVK+ + + LR+F EIE+L L+H ++V G C + + L+ E Sbjct: 871 LQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIME 930 Query: 171 YMEKGTLKSHLYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDE 350 Y+ G+L+ +L + K ++ +G+ Y T K IHRD+ + NIL++ Sbjct: 931 YLPYGSLRDYLQ-KHKERIDHIKLLQYTSQICKGMEYLGT---KRYIHRDLATRNILVEN 986 Query: 351 NLMAKVSDFGLSKTGPE 401 K+ DFGL+K P+ Sbjct: 987 ENRVKIGDFGLTKVLPQ 1003 Score = 41.2 bits (95), Expect = 0.002 Identities = 39/126 (30%), Positives = 65/126 (51%), Gaps = 10/126 (7%) Frame = +3 Query: 45 KSHQGLRE-FRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHL-YGSDM 218 K+H+ E F ++S L H+HLV G C +E ILV E+++ G+L ++L + Sbjct: 585 KAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNC 644 Query: 219 PPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILL--DENL------MAKVSD 374 + WK +E+ A +H+ ++IH +V + NILL +E+ K+SD Sbjct: 645 INILWK--LEVAKQLAWAMHFLE---ENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSD 699 Query: 375 FGLSKT 392 G+S T Sbjct: 700 PGISIT 705
>M3K11_HUMAN (Q16584) Mitogen-activated protein kinase kinase kinase 11 (EC| 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline-rich kinase) Length = 847 Score = 68.9 bits (167), Expect = 7e-12 Identities = 50/159 (31%), Positives = 75/159 (47%), Gaps = 12/159 (7%) Frame = +3 Query: 21 VAVKRGNQKSHQGL----REFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGT 188 VAVK Q + + R E L + L H ++++L C E+ + LV EY G Sbjct: 141 VAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGP 200 Query: 189 LKSHLYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILL-------- 344 L L G +PP V + ARG+HY H +IHRD+KS NILL Sbjct: 201 LSRALAGRRVPP---HVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDD 257 Query: 345 DENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPE 461 E+ K++DFGL++ + Q + G++ ++ PE Sbjct: 258 MEHKTLKITDFGLAREWHKTTQ----MSAAGTYAWMAPE 292
>STE11_YEAST (P23561) Serine/threonine-protein kinase STE11 (EC 2.7.11.1)| Length = 738 Score = 68.6 bits (166), Expect = 1e-11 Identities = 54/180 (30%), Positives = 91/180 (50%), Gaps = 10/180 (5%) Frame = +3 Query: 3 LQDSTKVAVKRGNQKSHQGLRE-FRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYME 179 ++D V+ + NQ H+ + + + E+ LL L H ++V+ G E + + EY+ Sbjct: 499 IEDVGAVSHPKTNQNIHRKMVDALQHEMNLLKELHHENIVTYYGASQEGGNLNIFLEYVP 558 Query: 180 KGTLKSHL--YGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDEN 353 G++ S L YG L +I IG A Y H K+IIHRD+K ANIL+D Sbjct: 559 GGSVSSMLNNYGPFEESLITNFTRQILIGVA----YLHK---KNIIHRDIKGANILIDIK 611 Query: 354 LMAKVSDFGLS-KTGPELDQTHVSTAVKGSFGYLDPEYYRRQS*P------TVGCVLIRV 512 K++DFG+S K P + + +++GS ++ PE ++ + + GCV+I + Sbjct: 612 GCVKITDFGISKKLSPLNKKQNKRASLQGSVFWMSPEVVKQTATTAKADIWSTGCVVIEM 671
>LCK_CHICK (P42683) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (Protein-tyrosine kinase C-TKL) (p56tk1) Length = 507 Score = 68.6 bits (166), Expect = 1e-11 Identities = 45/125 (36%), Positives = 69/125 (55%) Frame = +3 Query: 15 TKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLK 194 TKVA+K Q S F E L+ L+H LV L ++ + ++ EYMEKG+L Sbjct: 266 TKVAIKNLKQGS-MSPSAFLAEANLMKNLQHPRLVRLYAVVTKE-PIYIITEYMEKGSLV 323 Query: 195 SHLYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSD 374 L S+ L K +++ A G+ + AK+ IHRD+++ANIL+ E L K++D Sbjct: 324 DFLKTSEGIKLSINKLLDMAAQIAEGMAFIE---AKNYIHRDLRAANILVSEALCCKIAD 380 Query: 375 FGLSK 389 FGL++ Sbjct: 381 FGLAR 385
>LYN_MOUSE (P25911) Tyrosine-protein kinase Lyn (EC 2.7.10.2)| Length = 511 Score = 68.6 bits (166), Expect = 1e-11 Identities = 41/127 (32%), Positives = 70/127 (55%) Frame = +3 Query: 9 DSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGT 188 +STKVAVK + ++ F E L+ L+H LV L ++ + ++ E+M KG+ Sbjct: 267 NSTKVAVKT-LKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTKEEPIYIITEFMAKGS 325 Query: 189 LKSHLYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKV 368 L L + + K ++ A G+ Y K+ IHRD+++AN+L+ E+LM K+ Sbjct: 326 LLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIER---KNYIHRDLRAANVLVSESLMCKI 382 Query: 369 SDFGLSK 389 +DFGL++ Sbjct: 383 ADFGLAR 389
>CSK_CHICK (P41239) Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase)| Length = 450 Score = 68.6 bits (166), Expect = 1e-11 Identities = 44/133 (33%), Positives = 71/133 (53%), Gaps = 1/133 (0%) Frame = +3 Query: 18 KVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYC-DEQNEMILVYEYMEKGTLK 194 KVAVK K+ + F E +++ LRH +LV L+G +E++ + +V EYM KG+L Sbjct: 218 KVAVKC--IKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKSGLYIVTEYMAKGSLV 275 Query: 195 SHLYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSD 374 +L LG ++ + + Y A + +HRD+ + N+L+ E+ +AKVSD Sbjct: 276 DYLRSRGRSVLGGDCLLKFSLDVCEAMEYLE---ANNFVHRDLAARNVLVSEDNIAKVSD 332 Query: 375 FGLSKTGPELDQT 413 FGL+K T Sbjct: 333 FGLTKEASSTQDT 345
>CTR1_ARATH (Q05609) Serine/threonine-protein kinase CTR1 (EC 2.7.11.1)| Length = 821 Score = 68.6 bits (166), Expect = 1e-11 Identities = 43/138 (31%), Positives = 74/138 (53%), Gaps = 1/138 (0%) Frame = +3 Query: 60 LREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYGSDM-PPLGWK 236 + EF E+ ++ LRH ++V +G + + +V EY+ +G+L L+ S L + Sbjct: 590 VNEFLREVAIMKRLRHPNIVLFMGAVTQPPNLSIVTEYLSRGSLYRLLHKSGAREQLDER 649 Query: 237 KRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSKTGPELDQTH 416 +R+ + A+G++Y H I+HRD+KS N+L+D+ KV DFGLS+ + Sbjct: 650 RRLSMAYDVAKGMNYLHNR-NPPIVHRDLKSPNLLVDKKYTVKVCDFGLSRLKASTFLSS 708 Query: 417 VSTAVKGSFGYLDPEYYR 470 S A G+ ++ PE R Sbjct: 709 KSAA--GTPEWMAPEVLR 724
>IRAK2_HUMAN (O43187) Interleukin-1 receptor-associated kinase-like 2 (IRAK-2)| Length = 590 Score = 68.6 bits (166), Expect = 1e-11 Identities = 36/104 (34%), Positives = 58/104 (55%), Gaps = 1/104 (0%) Frame = +3 Query: 63 REFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYG-SDMPPLGWKK 239 R F+ E+++ H +++ ++G+C + +Y YM G+L+ L G PL W + Sbjct: 252 RFFQAELQICLRCCHPNVLPVLGFCAARQFHSFIYPYMANGSLQDRLQGQGGSDPLPWPQ 311 Query: 240 RVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVS 371 RV IC G + Y H IIH +VKS+N+LLD+NL K++ Sbjct: 312 RVSICSGLLCAVEYLH---GLEIIHSNVKSSNVLLDQNLTPKLA 352
>RAF1_HUMAN (P04049) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 68.6 bits (166), Expect = 1e-11 Identities = 44/136 (32%), Positives = 70/136 (51%) Frame = +3 Query: 69 FRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYGSDMPPLGWKKRVE 248 FR E+ +L RH +++ +GY + N + +V ++ E +L HL+ + + ++ Sbjct: 390 FRNEVAVLRKTRHVNILLFMGYMTKDN-LAIVTQWCEGSSLYKHLHVQETK-FQMFQLID 447 Query: 249 ICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSKTGPELDQTHVSTA 428 I A+G+ Y H AK+IIHRD+KS NI L E L K+ DFGL+ + Sbjct: 448 IARQTAQGMDYLH---AKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQ 504 Query: 429 VKGSFGYLDPEYYRRQ 476 GS ++ PE R Q Sbjct: 505 PTGSVLWMAPEVIRMQ 520
>PKN2_BACSU (O34507) Probable serine/threonine-protein kinase yloP (EC| 2.7.11.1) Length = 648 Score = 68.2 bits (165), Expect = 1e-11 Identities = 46/137 (33%), Positives = 70/137 (51%) Frame = +3 Query: 60 LREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYGSDMPPLGWKK 239 +R FR E + S L H ++VS+ +E + +V EY+E TLK ++ + PL K+ Sbjct: 53 IRRFRREAQSASSLDHPNIVSIYDLGEEDDIYYIVMEYVEGMTLKEYITANG--PLHPKE 110 Query: 240 RVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSKTGPELDQTHV 419 + I + + H I+HRD+K NIL+D KV+DFG++ TH Sbjct: 111 ALNIMEQIVSAIAHAHQN---QIVHRDIKPHNILIDHMGNIKVTDFGIATALSSTTITH- 166 Query: 420 STAVKGSFGYLDPEYYR 470 + +V GS YL PE R Sbjct: 167 TNSVLGSVHYLSPEQAR 183
>IPL1_ASHGO (Q755C4) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) Length = 367 Score = 68.2 bits (165), Expect = 1e-11 Identities = 45/140 (32%), Positives = 72/140 (51%), Gaps = 4/140 (2%) Frame = +3 Query: 63 REFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYG----SDMPPLG 230 ++FR E+E+ S LRH +L L GY ++ + L+ EY+ G L HL G +D+ Sbjct: 152 KQFRREVEIQSSLRHPNLTQLYGYFHDEKRVYLLMEYLVNGELYKHLKGRSHFNDVVASY 211 Query: 231 WKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSKTGPELDQ 410 + ++ A L Y H ++I+HRD+K NI++ N K++DFG S P+ + Sbjct: 212 YVYQM------ADALDYMH---ERNILHRDIKPENIIIGFNNTIKLTDFGWSVITPKGSK 262 Query: 411 THVSTAVKGSFGYLDPEYYR 470 + G+ YL PE R Sbjct: 263 ---RKTLCGTVDYLSPELIR 279
>M3K7_HUMAN (O43318) Mitogen-activated protein kinase kinase kinase 7 (EC| 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1) Length = 606 Score = 68.2 bits (165), Expect = 1e-11 Identities = 51/151 (33%), Positives = 85/151 (56%), Gaps = 2/151 (1%) Frame = +3 Query: 21 VAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSH 200 VA+K+ +S + + F E+ LS + H ++V L G C N + LV EY E G+L + Sbjct: 60 VAIKQIESESER--KAFIVELRQLSRVNHPNIVKLYGAC--LNPVCLVMEYAEGGSLYNV 115 Query: 201 LYGSD-MPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILL-DENLMAKVSD 374 L+G++ +P + C+ ++G+ Y H+ K++IHRD+K N+LL + K+ D Sbjct: 116 LHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICD 175 Query: 375 FGLSKTGPELDQTHVSTAVKGSFGYLDPEYY 467 FG T ++ QTH+ T KGS ++ PE + Sbjct: 176 FG---TACDI-QTHM-TNNKGSAAWMAPEVF 201
>M3K7_MOUSE (Q62073) Mitogen-activated protein kinase kinase kinase 7 (EC| 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1) Length = 579 Score = 68.2 bits (165), Expect = 1e-11 Identities = 51/151 (33%), Positives = 85/151 (56%), Gaps = 2/151 (1%) Frame = +3 Query: 21 VAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSH 200 VA+K+ +S + + F E+ LS + H ++V L G C N + LV EY E G+L + Sbjct: 60 VAIKQIESESER--KAFIVELRQLSRVNHPNIVKLYGAC--LNPVCLVMEYAEGGSLYNV 115 Query: 201 LYGSD-MPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILL-DENLMAKVSD 374 L+G++ +P + C+ ++G+ Y H+ K++IHRD+K N+LL + K+ D Sbjct: 116 LHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICD 175 Query: 375 FGLSKTGPELDQTHVSTAVKGSFGYLDPEYY 467 FG T ++ QTH+ T KGS ++ PE + Sbjct: 176 FG---TACDI-QTHM-TNNKGSAAWMAPEVF 201
>FGFR1_XENLA (P22182) Fibroblast growth factor receptor 1 precursor (EC| 2.7.10.1) (FGFR-1) Length = 812 Score = 68.2 bits (165), Expect = 1e-11 Identities = 45/165 (27%), Positives = 84/165 (50%), Gaps = 16/165 (9%) Frame = +3 Query: 15 TKVAVKR-GNQKSHQGLREFRTEIELLSGL-RHRHLVSLIGYCDEQNEMILVYEYMEKGT 188 TKVAVK + S + L + +E+E++ + +H+++++L+G C + + ++ EY KG Sbjct: 503 TKVAVKMLKSDASEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYTSKGN 562 Query: 189 LKSHLYGSDMPP--------------LGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVK 326 L+ +L P L +K V ARG+ Y + K IHRD+ Sbjct: 563 LREYLRARRPPAMEYCYNPTCVPDQLLSFKDLVSCAYQVARGMDYLAS---KKCIHRDLA 619 Query: 327 SANILLDENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPE 461 + N+L+ E+ + K++DFGL++ +D +T + ++ PE Sbjct: 620 ARNVLVTEDNIMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPE 664
>LIMK2_MOUSE (O54785) LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2)| Length = 638 Score = 68.2 bits (165), Expect = 1e-11 Identities = 38/109 (34%), Positives = 62/109 (56%) Frame = +3 Query: 63 REFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYGSDMPPLGWKKR 242 + F TE++++ L H +++ IG + ++ L+ EY+E GTLK L D P W+++ Sbjct: 371 KTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRSVD--PFPWQQK 428 Query: 243 VEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSK 389 V G + G+ Y H + IIHRD+ S N L+ + V+DFGLS+ Sbjct: 429 VRFAKGISSGMAYLH---SMCIIHRDLNSHNCLIKLDKTVVVADFGLSR 474
>PTK6_HUMAN (Q13882) Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor| kinase) (Tyrosine-protein kinase BRK) Length = 451 Score = 68.2 bits (165), Expect = 1e-11 Identities = 54/183 (29%), Positives = 90/183 (49%), Gaps = 20/183 (10%) Frame = +3 Query: 6 QDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKG 185 +D +VA+K ++ + + ++EI+ + LRH+H+++L + + ++ E M KG Sbjct: 211 KDRVQVAIKVISRDNLLHQQMLQSEIQAMKKLRHKHILALYAVVSVGDPVYIITELMAKG 270 Query: 186 TLKSHLYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAK 365 +L L SD L + ++I A G+ Y +++ IHRD+ + NIL+ EN + K Sbjct: 271 SLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLE---SQNYIHRDLAARNILVGENTLCK 327 Query: 366 VSDFGLSK------------------TGPE-LDQTHVST-AVKGSFGYLDPEYYRRQS*P 485 V DFGL++ T PE L + H ST + SFG L E + R P Sbjct: 328 VGDFGLARLIKEDVYLSHDHNIPYKWTAPEALSRGHYSTKSDVWSFGILLHEMFSRGQVP 387 Query: 486 TVG 494 G Sbjct: 388 YPG 390
>LYN_RAT (Q07014) Tyrosine-protein kinase Lyn (EC 2.7.10.2)| Length = 511 Score = 68.2 bits (165), Expect = 1e-11 Identities = 41/127 (32%), Positives = 69/127 (54%) Frame = +3 Query: 9 DSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGT 188 +STKVAVK + + F E L+ L+H LV L ++ + ++ E+M KG+ Sbjct: 267 NSTKVAVKT-LKPGTMSAQAFLEEANLMKTLQHDKLVRLYAVVTKEEPIYIITEFMAKGS 325 Query: 189 LKSHLYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKV 368 L L + + K ++ A G+ Y K+ IHRD+++AN+L+ E+LM K+ Sbjct: 326 LLDFLKSDEGSKVLLPKLIDFSAQIAEGMAYIER---KNYIHRDLRAANVLVSESLMCKI 382 Query: 369 SDFGLSK 389 +DFGL++ Sbjct: 383 ADFGLAR 389
>RIPK1_MOUSE (Q60855) Receptor-interacting serine/threonine-protein kinase 1 (EC| 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein) Length = 656 Score = 68.2 bits (165), Expect = 1e-11 Identities = 51/141 (36%), Positives = 71/141 (50%), Gaps = 12/141 (8%) Frame = +3 Query: 78 EIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYGSDMPPLGWKKRVEICI 257 E +++ LRH +V L+G E+ LV EYMEKG L L PL K R I + Sbjct: 63 EGKMMHRLRHSRVVKLLGIIIEEGNYSLVMEYMEKGNLMHVLKTQIDVPLSLKGR--IIV 120 Query: 258 GAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDFGL------SKTGPELD--QT 413 A G+ Y H K +IH+D+K NIL+D + K++D G+ SK E D Q Sbjct: 121 EAIEGMCYLHD---KGVIHKDLKPENILVDRDFHIKIADLGVASFKTWSKLTKEKDNKQK 177 Query: 414 HVSTAVK----GSFGYLDPEY 464 VS+ K G+ Y+ PE+ Sbjct: 178 EVSSTTKKNNGGTLYYMAPEH 198
>M3LK7_DROME (P83104) Putative mitogen-activated protein kinase kinase kinase| 7-like (EC 2.7.11.25) Length = 393 Score = 68.2 bits (165), Expect = 1e-11 Identities = 41/129 (31%), Positives = 73/129 (56%), Gaps = 1/129 (0%) Frame = +3 Query: 78 EIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYGSDMPPLGWKKRVEICI 257 EI LS + H +++ +IG + L+ EY+E+G+L ++LYG D ++ V + Sbjct: 54 EITHLSEIDHENVIRVIGRASNGKKDYLLMEYLEEGSLHNYLYGDDKWEYTVEQAVRWAL 113 Query: 258 GAARGLHYQHTGFAKSIIHRDVKSANILL-DENLMAKVSDFGLSKTGPELDQTHVSTAVK 434 A+ L Y H+ + I+HRD+K N+LL +++ K+ DFGL+ D ++ T ++ Sbjct: 114 QCAKALAYLHS-LDRPIVHRDIKPQNMLLYNQHEDLKICDFGLA-----TDMSNNKTDMQ 167 Query: 435 GSFGYLDPE 461 G+ Y+ PE Sbjct: 168 GTLRYMAPE 176
>M3K3_ARATH (O22042) Mitogen-activated protein kinase kinase kinase 3 (EC| 2.7.11.25) (Arabidospsis NPK1-related protein kinase 3) Length = 651 Score = 68.2 bits (165), Expect = 1e-11 Identities = 43/142 (30%), Positives = 77/142 (54%), Gaps = 2/142 (1%) Frame = +3 Query: 42 QKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHL--YGSD 215 +K+ +RE E++LL L H ++V +G E + + ++ E++ G++ S L +GS Sbjct: 109 EKTQGHIRELEEEVQLLKNLSHPNIVRYLGTVRESDSLNILMEFVPGGSISSLLEKFGSF 168 Query: 216 MPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSKTG 395 P+ ++ +G L Y H I+HRD+K ANIL+D +++DFG SK Sbjct: 169 PEPVIIMYTKQLLLG----LEYLHNN---GIMHRDIKGANILVDNKGCIRLADFGASKKV 221 Query: 396 PELDQTHVSTAVKGSFGYLDPE 461 EL + + ++KG+ ++ PE Sbjct: 222 VELATVNGAKSMKGTPYWMAPE 243
>M3KSL_DROME (Q95UN8) Mitogen-activated protein kinase kinase kinase (EC| 2.7.11.25) (Mixed lineage kinase) (dMLK) (Protein slipper) Length = 1161 Score = 68.2 bits (165), Expect = 1e-11 Identities = 51/163 (31%), Positives = 82/163 (50%), Gaps = 12/163 (7%) Frame = +3 Query: 9 DSTKVAVKRGNQKSHQGLREFRT----EIELLSGLRHRHLVSLIGYCDEQNEMILVYEYM 176 D +VA+K +Q ++ R E +L L+H ++ +L G C ++ LV EY Sbjct: 162 DGEEVAIKIAHQTGEDDMQRMRDNVLQEAKLFWALKHENIAALRGVC-LNTKLCLVMEYA 220 Query: 177 EKGTLKSHLYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENL 356 G+L L G P + V I ARG++Y H SIIHRD+KS+N+L+ E + Sbjct: 221 RGGSLNRILAGKIPPDV----LVNWAIQIARGMNYLHNEAPMSIIHRDLKSSNVLIYEAI 276 Query: 357 --------MAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPE 461 K++DFGL++ E+ T +A G++ ++ PE Sbjct: 277 EGNHLQQKTLKITDFGLAR---EMYNTQRMSAA-GTYAWMPPE 315
>TESK2_HUMAN (Q96S53) Dual specificity testis-specific protein kinase 2 (EC| 2.7.12.1) (Testicular protein kinase 2) Length = 571 Score = 67.8 bits (164), Expect = 2e-11 Identities = 47/134 (35%), Positives = 73/134 (54%), Gaps = 3/134 (2%) Frame = +3 Query: 78 EIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYGSDMPPLGWKKRVEICI 257 E++L++ L H +++ +G C Q ++ + EY+ G L+ L S++ L W RV++ Sbjct: 101 EVQLMNRLSHPNILRFMGVCVHQGQLHALTEYINSGNLE-QLLDSNL-HLPWTVRVKLAY 158 Query: 258 GAARGLHYQHTGFAKSIIHRDVKSANILL--DEN-LMAKVSDFGLSKTGPELDQTHVSTA 428 A GL Y H K I HRD+ S N L+ DEN A V+DFGL++ P++ A Sbjct: 159 DIAVGLSYLH---FKGIFHRDLTSKNCLIKRDENGYSAVVADFGLAEKIPDVSMGSEKLA 215 Query: 429 VKGSFGYLDPEYYR 470 V GS ++ PE R Sbjct: 216 VVGSPFWMAPEVLR 229
>STK_HYDAT (P17713) Tyrosine-protein kinase STK (EC 2.7.10.2) (P57-STK)| Length = 509 Score = 67.8 bits (164), Expect = 2e-11 Identities = 41/127 (32%), Positives = 68/127 (53%) Frame = +3 Query: 9 DSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGT 188 ++T+VAVK + F E ++ LRH+HLV L C ++ + +V EYM G+ Sbjct: 261 NTTQVAVKT-LKPGTMSPASFLDEAGVMKKLRHKHLVQLYAICSDREPIYIVTEYMSGGS 319 Query: 189 LKSHLYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKV 368 L +L + L +++ A G+ + A+ IHRD+ + NIL+ EN + KV Sbjct: 320 LLDYLSKGEGVNLQLPTLIDMAAQVASGMAFLE---AQGYIHRDLAARNILVGENYICKV 376 Query: 369 SDFGLSK 389 +DFGL++ Sbjct: 377 ADFGLAR 383
>ITK_HUMAN (Q08881) Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2)| (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT) Length = 620 Score = 67.8 bits (164), Expect = 2e-11 Identities = 48/150 (32%), Positives = 75/150 (50%) Frame = +3 Query: 18 KVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKS 197 KVA+K + + +F E E++ L H LV L G C EQ + LV+E+ME G L Sbjct: 387 KVAIKTIREGA-MSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSD 445 Query: 198 HLYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDF 377 +L + + + +C+ G+ Y +IHRD+ + N L+ EN + KVSDF Sbjct: 446 YL-RTQRGLFAAETLLGMCLDVCEGMAYLEEA---CVIHRDLAARNCLVGENQVIKVSDF 501 Query: 378 GLSKTGPELDQTHVSTAVKGSFGYLDPEYY 467 G+++ + DQ ST K + PE + Sbjct: 502 GMTRFVLD-DQYTSSTGTKFPVKWASPEVF 530
>SRC_RSVP (P00526) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 67.8 bits (164), Expect = 2e-11 Identities = 44/127 (34%), Positives = 69/127 (54%) Frame = +3 Query: 9 DSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGT 188 D+T+VA+K + F E +++ LRH LV L E+ + +V EYM KG+ Sbjct: 287 DTTRVAIKT-LKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEE-PIYIVIEYMSKGS 344 Query: 189 LKSHLYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKV 368 L L G L + V++ A G+ Y + +HRD+++ANIL+ ENL+ KV Sbjct: 345 LLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVER---MNYVHRDLRAANILVGENLVCKV 401 Query: 369 SDFGLSK 389 +DFGL++ Sbjct: 402 ADFGLAR 408
>FGFR1_CHICK (P21804) Basic fibroblast growth factor receptor 1 precursor (EC| 2.7.10.1) Length = 819 Score = 67.8 bits (164), Expect = 2e-11 Identities = 44/165 (26%), Positives = 84/165 (50%), Gaps = 16/165 (9%) Frame = +3 Query: 15 TKVAVKR-GNQKSHQGLREFRTEIELLSGL-RHRHLVSLIGYCDEQNEMILVYEYMEKGT 188 TKVAVK + + + L + +E+E++ + +H+++++L+G C + + ++ EY KG Sbjct: 507 TKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGN 566 Query: 189 LKSHLYGSDMP--------------PLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVK 326 L+ +L P L +K V ARG+ Y + K IHRD+ Sbjct: 567 LREYLQARRPPGMEYCYNPTRIPEEQLSFKDLVSCAYQVARGMEYLAS---KKCIHRDLA 623 Query: 327 SANILLDENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPE 461 + N+L+ E+ + K++DFGL++ +D +T + ++ PE Sbjct: 624 ARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPE 668
>MATK_RAT (P41243) Megakaryocyte-associated tyrosine-protein kinase (EC| 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase BATK) Length = 467 Score = 67.4 bits (163), Expect = 2e-11 Identities = 43/124 (34%), Positives = 70/124 (56%) Frame = +3 Query: 18 KVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKS 197 KVAVK N K + F E +++ L+HR+LV L+G + +V E++ KG L + Sbjct: 217 KVAVK--NIKCDVTAQAFLDETAVMTKLQHRNLVRLLGVILHHG-LYIVMEHVSKGNLVN 273 Query: 198 HLYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDF 377 L + + ++ + A G+ Y + K ++HRD+ + NIL+ E+L+AKVSDF Sbjct: 274 FLRTRGRALVSTSQLLQFALHVAEGMEYLES---KKLVHRDLAARNILVSEDLVAKVSDF 330 Query: 378 GLSK 389 GL+K Sbjct: 331 GLAK 334
>MATK_MOUSE (P41242) Megakaryocyte-associated tyrosine-protein kinase (EC| 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK) Length = 505 Score = 67.4 bits (163), Expect = 2e-11 Identities = 43/124 (34%), Positives = 70/124 (56%) Frame = +3 Query: 18 KVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKS 197 KVAVK N K + F E +++ L+HR+LV L+G + +V E++ KG L + Sbjct: 256 KVAVK--NIKCDVTAQAFLDETAVMTKLQHRNLVRLLGVILHHG-LYIVMEHVSKGNLVN 312 Query: 198 HLYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDF 377 L + + ++ + A G+ Y + K ++HRD+ + NIL+ E+L+AKVSDF Sbjct: 313 FLRTRGRALVSTSQLLQFALHVAEGMEYLES---KKLVHRDLAARNILVSEDLVAKVSDF 369 Query: 378 GLSK 389 GL+K Sbjct: 370 GLAK 373
>TYK2_MOUSE (Q9R117) Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2)| Length = 1180 Score = 67.4 bits (163), Expect = 2e-11 Identities = 46/130 (35%), Positives = 70/130 (53%), Gaps = 3/130 (2%) Frame = +3 Query: 21 VAVKRGNQKSHQGLRE-FRTEIELLSGLRHRHLVSLIGYCDEQNE--MILVYEYMEKGTL 191 VAVK + LR ++ EIE+L L H H+V G C++Q E + LV EY+ G+L Sbjct: 920 VAVKALKEGCGPQLRSGWQREIEILRTLYHEHIVKYKGCCEDQGEKSVQLVMEYVPLGSL 979 Query: 192 KSHLYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVS 371 + +L +G + + G+ Y H A+ IHRD+ + N+LLD + + K+ Sbjct: 980 RDYL---PRHCVGLAQLLLFAQQICEGMAYLH---AQHYIHRDLAARNVLLDNDRLVKIG 1033 Query: 372 DFGLSKTGPE 401 DFGL+K PE Sbjct: 1034 DFGLAKAVPE 1043 Score = 41.2 bits (95), Expect = 0.002 Identities = 39/132 (29%), Positives = 58/132 (43%), Gaps = 8/132 (6%) Frame = +3 Query: 18 KVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKS 197 +V +K + H F L+S + H HL L G C +E I+V E++E G L Sbjct: 631 RVVLKVLDPSHHDIALAFYEXASLMSQVSHMHLAFLHGVCVRGSENIIVTEFVEHGPLDV 690 Query: 198 HLYGS-DMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILL-------DEN 353 L P+ WK V + +A L Y K+++H +V NILL N Sbjct: 691 WLRRQRGQVPMTWKMVVAQQLASA--LSYLED---KNLVHGNVCGRNILLARLGLEEGTN 745 Query: 354 LMAKVSDFGLSK 389 K+SD G+ + Sbjct: 746 PFIKLSDPGVGQ 757
>RIPK1_HUMAN (Q13546) Receptor-interacting serine/threonine-protein kinase 1 (EC| 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein) Length = 671 Score = 67.0 bits (162), Expect = 3e-11 Identities = 39/103 (37%), Positives = 57/103 (55%) Frame = +3 Query: 78 EIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYGSDMPPLGWKKRVEICI 257 E ++++ LRH +V L+G E+ + LV EYMEKG L L PL K R I + Sbjct: 63 EAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGR--IIL 120 Query: 258 GAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLS 386 G+ Y H K +IH+D+K NIL+D + K++D GL+ Sbjct: 121 EIIEGMCYLH---GKGVIHKDLKPENILVDNDFHIKIADLGLA 160
>TNI3K_MOUSE (Q5GIG6) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 833 Score = 67.0 bits (162), Expect = 3e-11 Identities = 48/153 (31%), Positives = 83/153 (54%), Gaps = 4/153 (2%) Frame = +3 Query: 21 VAVKRGNQKSHQGLRE---FRTEIELLSGLRHRHLVSLIGYC-DEQNEMILVYEYMEKGT 188 VA+KR ++ + F E+ +L L H +V +G C D+ ++ +V +Y+ G+ Sbjct: 485 VAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVVQFVGACLDDPSQFAIVTQYISGGS 544 Query: 189 LKSHLYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKV 368 L S L+ L + ++ I + A+G+ Y H+ + IIHRD+ S NILL E+ A V Sbjct: 545 LFSLLH-EQKRILDLQSKLIIAVDVAKGMEYLHS-LTQPIIHRDLNSHNILLYEDGHAVV 602 Query: 369 SDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYY 467 +DFG S+ LD+ ++ T G+ ++ PE + Sbjct: 603 ADFGESRFLQSLDEDNM-TKQPGNLRWMAPEVF 634
>FPS_FUJSV (P00530) Tyrosine-protein kinase transforming protein FPS (EC| 2.7.10.2) Length = 873 Score = 67.0 bits (162), Expect = 3e-11 Identities = 48/140 (34%), Positives = 73/140 (52%), Gaps = 1/140 (0%) Frame = +3 Query: 9 DSTKVAVKRGNQKSHQGLR-EFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKG 185 D+T VAVK + L+ +F E +L H ++V LIG C ++ + +V E ++ G Sbjct: 634 DNTPVAVKSCRETLPPELKAKFLQEARILKQCNHPNIVRLIGVCTQKQPIYIVMELVQGG 693 Query: 186 TLKSHLYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAK 365 S L S P L KK +++ AA G+ Y + K IHRD+ + N L+ E K Sbjct: 694 DFLSFLR-SKGPRLKMKKLIKMMENAAAGMEYLES---KHCIHRDLAARNCLVTEKNTLK 749 Query: 366 VSDFGLSKTGPELDQTHVST 425 +SDFG+S+ E D + ST Sbjct: 750 ISDFGMSR--QEEDGVYAST 767
>TESK2_MOUSE (Q8VCT9) Dual specificity testis-specific protein kinase 2 (EC| 2.7.12.1) (Testicular protein kinase 2) Length = 570 Score = 67.0 bits (162), Expect = 3e-11 Identities = 48/134 (35%), Positives = 72/134 (53%), Gaps = 3/134 (2%) Frame = +3 Query: 78 EIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYGSDMPPLGWKKRVEICI 257 E++L++ L H +++ +G C Q ++ + EY+ G L+ L SD+ L W RV++ Sbjct: 101 EMQLMNRLSHPNILRFMGVCVHQGQLHALTEYINSGNLE-QLLDSDL-YLPWTVRVKLAY 158 Query: 258 GAARGLHYQHTGFAKSIIHRDVKSANILL--DEN-LMAKVSDFGLSKTGPELDQTHVSTA 428 A GL Y H K I HRD+ S N L+ DEN A V+DFGL++ P+ A Sbjct: 159 DIAVGLSYLH---FKGIFHRDLTSKNCLIKRDENGYSAVVADFGLAEKIPDASIGREKLA 215 Query: 429 VKGSFGYLDPEYYR 470 V GS ++ PE R Sbjct: 216 VVGSPFWMAPEVLR 229
>FGFR1_RAT (Q04589) Basic fibroblast growth factor receptor 1 precursor (EC| 2.7.10.1) (FGFR-1) (bFGF-R) (MFR) Length = 822 Score = 67.0 bits (162), Expect = 3e-11 Identities = 44/165 (26%), Positives = 84/165 (50%), Gaps = 16/165 (9%) Frame = +3 Query: 15 TKVAVKR-GNQKSHQGLREFRTEIELLSGL-RHRHLVSLIGYCDEQNEMILVYEYMEKGT 188 TKVAVK + + + L + +E+E++ + +H+++++L+G C + + ++ EY KG Sbjct: 509 TKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGN 568 Query: 189 LKSHLYGSDMPPLGW--------------KKRVEICIGAARGLHYQHTGFAKSIIHRDVK 326 L+ +L P L + K V ARG+ Y + K IHRD+ Sbjct: 569 LREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLAS---KKCIHRDLA 625 Query: 327 SANILLDENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPE 461 + N+L+ E+ + K++DFGL++ +D +T + ++ PE Sbjct: 626 ARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPE 670
>FGFR1_MOUSE (P16092) Basic fibroblast growth factor receptor 1 precursor (EC| 2.7.10.1) (FGFR-1) (bFGF-R) (MFR) Length = 822 Score = 67.0 bits (162), Expect = 3e-11 Identities = 44/165 (26%), Positives = 84/165 (50%), Gaps = 16/165 (9%) Frame = +3 Query: 15 TKVAVKR-GNQKSHQGLREFRTEIELLSGL-RHRHLVSLIGYCDEQNEMILVYEYMEKGT 188 TKVAVK + + + L + +E+E++ + +H+++++L+G C + + ++ EY KG Sbjct: 509 TKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGN 568 Query: 189 LKSHLYGSDMPPLGW--------------KKRVEICIGAARGLHYQHTGFAKSIIHRDVK 326 L+ +L P L + K V ARG+ Y + K IHRD+ Sbjct: 569 LREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLAS---KKCIHRDLA 625 Query: 327 SANILLDENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPE 461 + N+L+ E+ + K++DFGL++ +D +T + ++ PE Sbjct: 626 ARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPE 670
>FGFR1_HUMAN (P11362) Basic fibroblast growth factor receptor 1 precursor (EC| 2.7.10.1) (FGFR-1) (bFGF-R) (Fms-like tyrosine kinase 2) (c-fgr) (CD331 antigen) Length = 822 Score = 67.0 bits (162), Expect = 3e-11 Identities = 44/165 (26%), Positives = 84/165 (50%), Gaps = 16/165 (9%) Frame = +3 Query: 15 TKVAVKR-GNQKSHQGLREFRTEIELLSGL-RHRHLVSLIGYCDEQNEMILVYEYMEKGT 188 TKVAVK + + + L + +E+E++ + +H+++++L+G C + + ++ EY KG Sbjct: 509 TKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGN 568 Query: 189 LKSHLYGSDMPPLGW--------------KKRVEICIGAARGLHYQHTGFAKSIIHRDVK 326 L+ +L P L + K V ARG+ Y + K IHRD+ Sbjct: 569 LREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLAS---KKCIHRDLA 625 Query: 327 SANILLDENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPE 461 + N+L+ E+ + K++DFGL++ +D +T + ++ PE Sbjct: 626 ARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPE 670
>LIMK1_DROME (Q8IR79) LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (dLIMK)| Length = 1257 Score = 67.0 bits (162), Expect = 3e-11 Identities = 45/147 (30%), Positives = 74/147 (50%), Gaps = 2/147 (1%) Frame = +3 Query: 6 QDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKG 185 Q + +K ++ + R F E+ +L L HRH++ IG + ++ +V EY+ G Sbjct: 422 QSGEVMVLKELHRADEEAQRNFIKEVAVLRLLDHRHVLKFIGVLYKDKKLHMVTEYVAGG 481 Query: 186 TLKSHLYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAK 365 LK L L W +RV + A G+ Y H + +IIHRD+ S N L+ E+ Sbjct: 482 CLK-ELIHDPAQVLPWPQRVRLARDIACGMSYLH---SMNIIHRDLNSMNCLVREDRSVI 537 Query: 366 VSDFGLSKT--GPELDQTHVSTAVKGS 440 V+DFGL+++ P L +++ GS Sbjct: 538 VADFGLARSVDAPRLPSGNMTPGGYGS 564
>TNI3K_RAT (Q7TQP6) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 834 Score = 67.0 bits (162), Expect = 3e-11 Identities = 48/153 (31%), Positives = 83/153 (54%), Gaps = 4/153 (2%) Frame = +3 Query: 21 VAVKRGNQKSHQGLRE---FRTEIELLSGLRHRHLVSLIGYC-DEQNEMILVYEYMEKGT 188 VA+KR ++ + F E+ +L L H +V +G C D+ ++ +V +Y+ G+ Sbjct: 486 VAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVVQFVGACLDDPSQFAIVTQYISGGS 545 Query: 189 LKSHLYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKV 368 L S L+ L + ++ I + A+G+ Y H+ + IIHRD+ S NILL E+ A V Sbjct: 546 LFSLLH-EQKRILDLQSKLIIAVDVAKGMEYLHS-LTQPIIHRDLNSHNILLYEDGHAVV 603 Query: 369 SDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYY 467 +DFG S+ LD+ ++ T G+ ++ PE + Sbjct: 604 ADFGESRFLQSLDEDNM-TKQPGNLRWMAPEVF 635
>TYK2_HUMAN (P29597) Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2)| Length = 1187 Score = 66.6 bits (161), Expect = 4e-11 Identities = 38/113 (33%), Positives = 63/113 (55%), Gaps = 2/113 (1%) Frame = +3 Query: 69 FRTEIELLSGLRHRHLVSLIGYCDEQNE--MILVYEYMEKGTLKSHLYGSDMPPLGWKKR 242 ++ EI++L L H H++ G C++Q E + LV EY+ G+L+ +L +G + Sbjct: 944 WKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYL---PRHSIGLAQL 1000 Query: 243 VEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSKTGPE 401 + G+ Y H A+ IHRD+ + N+LLD + + K+ DFGL+K PE Sbjct: 1001 LLFAQQICEGMAYLH---AQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPE 1050 Score = 40.0 bits (92), Expect = 0.004 Identities = 34/110 (30%), Positives = 49/110 (44%), Gaps = 1/110 (0%) Frame = +3 Query: 18 KVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKS 197 +V +K + H F L+S + H HL + G C E I+V EY+E G L Sbjct: 638 RVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDV 697 Query: 198 HLYGS-DMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILL 344 L P+ WK V + +A L Y K+++H +V NILL Sbjct: 698 WLRRERGHVPMAWKMVVAQQLASA--LSYLEN---KNLVHGNVCGRNILL 742
>ANPRA_MOUSE (P18293) Atrial natriuretic peptide receptor A precursor (ANP-A)| (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor) Length = 1057 Score = 66.6 bits (161), Expect = 4e-11 Identities = 47/159 (29%), Positives = 80/159 (50%), Gaps = 1/159 (0%) Frame = +3 Query: 21 VAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSH 200 VAVKR N+K + R+ E++ + +++ HL +G C + + ++ EY +G+L+ Sbjct: 560 VAVKRVNRKRIELTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQDI 619 Query: 201 LYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDFG 380 L + L W R + +G+ + H G S H ++KS+N ++D + K++D+G Sbjct: 620 LENESI-TLDWMFRYSLTNDIVKGMLFLHNGAIGS--HGNLKSSNCVVDGRFVLKITDYG 676 Query: 381 L-SKTGPELDQTHVSTAVKGSFGYLDPEYYRRQS*PTVG 494 L S PE +Q H A K + PE R S P G Sbjct: 677 LESFRDPEPEQGHTLFAKK---LWTAPELLRMASPPARG 712
>PKNX_STRCO (Q9XA16) Probable serine/threonine-protein kinase SCO3848 (EC| 2.7.11.1) Length = 673 Score = 66.6 bits (161), Expect = 4e-11 Identities = 49/157 (31%), Positives = 78/157 (49%), Gaps = 12/157 (7%) Frame = +3 Query: 69 FRTEIELLSGLRHRHLVSLIG----YCDEQNEMILVYEYMEKGTLKSHLY-GSDMPPLGW 233 FR E + + L H +V++ Y D + +V EY++ TL+ L+ G + P Sbjct: 56 FRREAQSAASLNHPAIVAVYDTGEDYIDNVSIPYIVMEYVDGSTLRELLHSGRKLLP--- 112 Query: 234 KKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSKTGPELDQT 413 ++ +E+ IG + L Y H I+HRD+K AN++L N KV DFG+++ + T Sbjct: 113 ERTLEMTIGILQALEYSHRA---GIVHRDIKPANVMLTRNGQVKVMDFGIARAMGDSGMT 169 Query: 414 HVST-AVKGSFGYLDPEYYR------RQS*PTVGCVL 503 T AV G+ YL PE + R + GC+L Sbjct: 170 MTQTAAVIGTAQYLSPEQAKGEQVDARSDLYSTGCLL 206
>CSK_RAT (P32577) Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase)| Length = 450 Score = 66.6 bits (161), Expect = 4e-11 Identities = 43/133 (32%), Positives = 69/133 (51%), Gaps = 1/133 (0%) Frame = +3 Query: 18 KVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYC-DEQNEMILVYEYMEKGTLK 194 KVAVK K+ + F E +++ LRH +LV L+G +E+ + +V EYM KG+L Sbjct: 218 KVAVKC--IKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLV 275 Query: 195 SHLYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSD 374 +L LG ++ + + Y + +HRD+ + N+L+ E+ +AKVSD Sbjct: 276 DYLRSRGRSVLGGDCLLKFSLDVCEAMEYLE---GNNFVHRDLAARNVLVSEDNVAKVSD 332 Query: 375 FGLSKTGPELDQT 413 FGL+K T Sbjct: 333 FGLTKEASSTQDT 345
>CSK_HUMAN (P41240) Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase)| (Protein-tyrosine kinase CYL) Length = 450 Score = 66.6 bits (161), Expect = 4e-11 Identities = 43/133 (32%), Positives = 69/133 (51%), Gaps = 1/133 (0%) Frame = +3 Query: 18 KVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYC-DEQNEMILVYEYMEKGTLK 194 KVAVK K+ + F E +++ LRH +LV L+G +E+ + +V EYM KG+L Sbjct: 218 KVAVKC--IKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLV 275 Query: 195 SHLYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSD 374 +L LG ++ + + Y + +HRD+ + N+L+ E+ +AKVSD Sbjct: 276 DYLRSRGRSVLGGDCLLKFSLDVCEAMEYLE---GNNFVHRDLAARNVLVSEDNVAKVSD 332 Query: 375 FGLSKTGPELDQT 413 FGL+K T Sbjct: 333 FGLTKEASSTQDT 345
>SRC_RSVPA (P31693) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 522 Score = 66.6 bits (161), Expect = 4e-11 Identities = 44/126 (34%), Positives = 68/126 (53%) Frame = +3 Query: 12 STKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTL 191 +T+VA+K + F E +++ LRH LV L E+ + +V EYM KG+L Sbjct: 285 TTRVAIKT-LKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAMVSEE-PIYIVIEYMSKGSL 342 Query: 192 KSHLYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVS 371 L G L + VE+ A G+ Y + +HRD+++ANIL+ ENL+ KV+ Sbjct: 343 LDFLKGEMGKYLRLPQLVEMAAQIASGMAYVER---MNYVHRDLRAANILVGENLVCKVA 399 Query: 372 DFGLSK 389 DFGL++ Sbjct: 400 DFGLAR 405
>M3K7_DROME (Q9V3Q6) Mitogen-activated protein kinase kinase kinase 7 (EC| 2.7.11.25) (TGF-beta-activated kinase 1) (dTAK1) Length = 678 Score = 66.2 bits (160), Expect = 5e-11 Identities = 45/150 (30%), Positives = 74/150 (49%), Gaps = 1/150 (0%) Frame = +3 Query: 21 VAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSH 200 VAVK + Q ++ E++ LS ++H ++++L G Q L+ E+ E G+L + Sbjct: 43 VAVKEFFASAEQ--KDIEKEVKQLSRVKHPNIIALHGISSYQQATYLIMEFAEGGSLHNF 100 Query: 201 LYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILL-DENLMAKVSDF 377 L+G P + A GL Y H K +IHRDVK N+LL ++ K+ DF Sbjct: 101 LHGKVKPAYSLAHAMSWARQCAEGLAYLHAMTPKPLIHRDVKPLNLLLTNKGRNLKICDF 160 Query: 378 GLSKTGPELDQTHVSTAVKGSFGYLDPEYY 467 G D++ + T +GS ++ PE + Sbjct: 161 -----GTVADKSTMMTNNRGSAAWMAPEVF 185
>MIL_AVIMH (P00531) Serine/threonine-protein kinase transforming protein mil| (EC 2.7.11.1) Length = 380 Score = 66.2 bits (160), Expect = 5e-11 Identities = 43/136 (31%), Positives = 69/136 (50%) Frame = +3 Query: 69 FRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYGSDMPPLGWKKRVE 248 FR E+ +L RH +++ +GY + N + +V ++ E +L HL+ + + ++ Sbjct: 123 FRNEVAVLRKTRHVNILLFMGYMTKDN-LAIVTQWCEGSSLYKHLHVQETK-FQMFQLID 180 Query: 249 ICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSKTGPELDQTHVSTA 428 I A+G+ Y H AK+IIHRD+KS NI L L K+ DFGL+ + Sbjct: 181 IARQTAQGMDYLH---AKNIIHRDMKSNNIFLHGGLTVKIGDFGLATVKSRWSGSQQVEQ 237 Query: 429 VKGSFGYLDPEYYRRQ 476 GS ++ PE R Q Sbjct: 238 PTGSILWMAPEVIRMQ 253
>SRC_RSVSE (P63185) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 66.2 bits (160), Expect = 5e-11 Identities = 43/126 (34%), Positives = 69/126 (54%) Frame = +3 Query: 12 STKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTL 191 +T+VA+K + F E +++ LRH+ LV L E+ + +V EYM KG+L Sbjct: 288 TTRVAIKT-LKPGTMSPEAFLQEAQVMKKLRHKKLVQLYAVVSEE-PIYIVIEYMSKGSL 345 Query: 192 KSHLYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVS 371 L G L + V++ A G+ Y + +HRD+++ANIL+ ENL+ KV+ Sbjct: 346 LDFLKGEMGKYLRLPQLVDMAAQIASGMAYVER---MNYVHRDLRAANILVGENLVCKVA 402 Query: 372 DFGLSK 389 DFGL++ Sbjct: 403 DFGLAR 408
>SRK4_SPOLA (P42690) Tyrosine-protein kinase isoform SRK4 (EC 2.7.10.2)| Length = 506 Score = 66.2 bits (160), Expect = 5e-11 Identities = 42/126 (33%), Positives = 68/126 (53%) Frame = +3 Query: 12 STKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTL 191 +T VAVK + + EF E ++ LRH L+ L C ++ + +V E M+ G+L Sbjct: 262 TTSVAVKT-LKPGTMSIEEFLEEASIMKQLRHPKLIQLYAVCTKEEPIYIVTELMKHGSL 320 Query: 192 KSHLYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVS 371 +L G D L V++C A G+ Y ++ IHRD+ + NIL+ E+ + KV+ Sbjct: 321 LEYLRG-DGRSLKLPDLVDMCSQVASGMSYLEQ---QNYIHRDLAARNILVGEHKICKVA 376 Query: 372 DFGLSK 389 DFGL++ Sbjct: 377 DFGLAR 382
>ANPRA_RAT (P18910) Atrial natriuretic peptide receptor A precursor (ANP-A)| (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor) Length = 1057 Score = 66.2 bits (160), Expect = 5e-11 Identities = 47/159 (29%), Positives = 80/159 (50%), Gaps = 1/159 (0%) Frame = +3 Query: 21 VAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSH 200 VAVKR N+K + R+ E++ + +++ HL +G C + + ++ EY +G+L+ Sbjct: 560 VAVKRVNRKRIELTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQDI 619 Query: 201 LYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDFG 380 L + L W R + +G+ + H G S H ++KS+N ++D + K++D+G Sbjct: 620 LENESI-TLDWMFRYSLTNDIVKGMLFLHNGAICS--HGNLKSSNCVVDGRFVLKITDYG 676 Query: 381 L-SKTGPELDQTHVSTAVKGSFGYLDPEYYRRQS*PTVG 494 L S PE +Q H A K + PE R S P G Sbjct: 677 LESFRDPEPEQGHTLFAKK---LWTAPELLRMASPPARG 712
>M3K10_HUMAN (Q02779) Mitogen-activated protein kinase kinase kinase 10 (EC| 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST) Length = 954 Score = 66.2 bits (160), Expect = 5e-11 Identities = 45/141 (31%), Positives = 70/141 (49%), Gaps = 10/141 (7%) Frame = +3 Query: 78 EIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYGSDMPPLGWKKRVEICI 257 E L L+H ++++L G C + LV EY G L L G +PP V + Sbjct: 145 EARLFGALQHPNIIALRGACLNPPHLCLVMEYARGGALSRVLAGRRVPP---HVLVNWAV 201 Query: 258 GAARGLHYQHTGFAKSIIHRDVKSANILLDE--------NLMAKVSDFGLSKTGPELDQT 413 ARG++Y H IIHRD+KS NIL+ E + + K++DFGL++ + Sbjct: 202 QVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAR------EW 255 Query: 414 HVST--AVKGSFGYLDPEYYR 470 H +T + G++ ++ PE R Sbjct: 256 HKTTKMSAAGTYAWMAPEVIR 276
>CSK_MOUSE (P41241) Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase)| (Protein-tyrosine kinase MPK-2) (p50CSK) Length = 450 Score = 66.2 bits (160), Expect = 5e-11 Identities = 43/133 (32%), Positives = 69/133 (51%), Gaps = 1/133 (0%) Frame = +3 Query: 18 KVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYC-DEQNEMILVYEYMEKGTLK 194 KVAVK K+ + F E +++ LRH +LV L+G +E+ + +V EYM KG+L Sbjct: 218 KVAVKC--IKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLV 275 Query: 195 SHLYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSD 374 +L LG ++ + + Y + +HRD+ + N+L+ E+ +AKVSD Sbjct: 276 DYLRSRGRSVLGGDCLLKFSLDVLEAMEYLE---GNNFVHRDLAARNVLVSEDNVAKVSD 332 Query: 375 FGLSKTGPELDQT 413 FGL+K T Sbjct: 333 FGLTKEASSTQDT 345
>FER_HUMAN (P16591) Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2)| (p94-FER) (c-FER) Length = 822 Score = 66.2 bits (160), Expect = 5e-11 Identities = 43/130 (33%), Positives = 71/130 (54%), Gaps = 1/130 (0%) Frame = +3 Query: 3 LQDSTKVAVKRGNQKSHQGLR-EFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYME 179 L+D T VAVK + Q L+ +F E ++L H ++V LIG C ++ + ++ E + Sbjct: 582 LKDKTSVAVKTCKEDLPQELKIKFLQEAKILKQYDHPNIVKLIGVCTQRQPVYIIMELVS 641 Query: 180 KGTLKSHLYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLM 359 G + L L K+ V+ + AA G+ Y + K+ IHRD+ + N L+ EN + Sbjct: 642 GGDFLTFLRRKK-DELKLKQLVKFSLDAAAGMLYLES---KNCIHRDLAARNCLVGENNV 697 Query: 360 AKVSDFGLSK 389 K+SDFG+S+ Sbjct: 698 LKISDFGMSR 707
>SRC_HUMAN (P12931) Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2)| (p60-Src) (c-Src) (pp60c-src) Length = 535 Score = 65.9 bits (159), Expect = 6e-11 Identities = 43/126 (34%), Positives = 68/126 (53%) Frame = +3 Query: 12 STKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTL 191 +T+VA+K + F E +++ LRH LV L E+ + +V EYM KG+L Sbjct: 291 TTRVAIKT-LKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEE-PIYIVTEYMSKGSL 348 Query: 192 KSHLYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVS 371 L G L + V++ A G+ Y + +HRD+++ANIL+ ENL+ KV+ Sbjct: 349 LDFLKGETGKYLRLPQLVDMAAQIASGMAYVER---MNYVHRDLRAANILVGENLVCKVA 405 Query: 372 DFGLSK 389 DFGL++ Sbjct: 406 DFGLAR 411
>FYN_XIPHE (P27446) Proto-oncogene tyrosine-protein kinase FYN (EC 2.7.10.2)| (P59-FYN) Length = 536 Score = 65.9 bits (159), Expect = 6e-11 Identities = 44/126 (34%), Positives = 67/126 (53%) Frame = +3 Query: 12 STKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTL 191 +TKVAVK + F E +++ LRH LV L E+ + +V EYM KG+L Sbjct: 292 TTKVAVKT-LKPGTMSPESFLEEAQIMKKLRHDKLVQLYAVVSEE-PIYIVTEYMSKGSL 349 Query: 192 KSHLYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVS 371 L + L V++ A G+ Y + IHRD++SANIL+ +NL+ K++ Sbjct: 350 LDFLKDGEGRALKLPNLVDMAAQVAAGMAYIER---MNYIHRDLRSANILVGDNLVCKIA 406 Query: 372 DFGLSK 389 DFGL++ Sbjct: 407 DFGLAR 412
>ROR1_DROME (Q24488) Tyrosine-protein kinase transmembrane receptor Ror| precursor (EC 2.7.10.1) (dRor) Length = 685 Score = 65.9 bits (159), Expect = 6e-11 Identities = 35/112 (31%), Positives = 65/112 (58%), Gaps = 3/112 (2%) Frame = +3 Query: 63 REFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYG---SDMPPLGW 233 ++F+ EIEL+S L+H+++V ++G + +++EYM G L L ++ L Sbjct: 454 QDFKREIELISDLKHQNIVCILGVVLNKEPYCMLFEYMANGDLHEFLISNSPTEGKSLSQ 513 Query: 234 KKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSK 389 + ++I + + G+ Y A +HRD+ + N L++E L+ K+SDFGLS+ Sbjct: 514 LEFLQIALQISEGMQYLS---AHHYVHRDLAARNCLVNEGLVVKISDFGLSR 562
>MATK_HUMAN (P42679) Megakaryocyte-associated tyrosine-protein kinase (EC| 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase) Length = 507 Score = 65.9 bits (159), Expect = 6e-11 Identities = 42/124 (33%), Positives = 70/124 (56%) Frame = +3 Query: 18 KVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKS 197 KVAVK N K + F E +++ ++H +LV L+G Q + +V E++ KG L + Sbjct: 258 KVAVK--NIKCDVTAQAFLDETAVMTKMQHENLVRLLGVILHQG-LYIVMEHVSKGNLVN 314 Query: 198 HLYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDF 377 L + + ++ + A G+ Y + K ++HRD+ + NIL+ E+L+AKVSDF Sbjct: 315 FLRTRGRALVNTAQLLQFSLHVAEGMEYLES---KKLVHRDLAARNILVSEDLVAKVSDF 371 Query: 378 GLSK 389 GL+K Sbjct: 372 GLAK 375
>PTK6_MOUSE (Q64434) Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related| intestinal kinase) Length = 451 Score = 65.9 bits (159), Expect = 6e-11 Identities = 40/123 (32%), Positives = 66/123 (53%) Frame = +3 Query: 21 VAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSH 200 VAVK ++ + F+ EI+ + LRH+H++SL + + ++ E M KG L Sbjct: 216 VAVKVISRDNLLHQHTFQAEIQAMKKLRHKHILSLYAVATAGDPVYIITELMPKGNLLQL 275 Query: 201 LYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDFG 380 L SD L + V+ A G+ Y +++ IHRD+ + N+L+ EN + KV DFG Sbjct: 276 LRDSDEKALPILELVDFASQVAEGMCYLE---SQNYIHRDLAARNVLVTENNLCKVGDFG 332 Query: 381 LSK 389 L++ Sbjct: 333 LAR 335
>BCK1_YEAST (Q01389) Serine/threonine-protein kinase BCK1/SLK1/SSP31 (EC| 2.7.11.1) Length = 1478 Score = 65.9 bits (159), Expect = 6e-11 Identities = 43/156 (27%), Positives = 85/156 (54%), Gaps = 9/156 (5%) Frame = +3 Query: 72 RTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKS--HLYGSDMPPLGWKKRV 245 R+E+ L L H ++V +G+ ++ N L EY+ G++ S +YG PL Sbjct: 1226 RSEVSTLKDLDHLNIVQYLGFENKNNIYSLFLEYVAGGSVGSLIRMYGRFDEPLIKHLTT 1285 Query: 246 EICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSKTGPELDQTHVST 425 ++ +GL Y H+ K I+HRD+K+ N+LLD++ + K+SDFG+S+ ++ ++ Sbjct: 1286 QVL----KGLAYLHS---KGILHRDMKADNLLLDQDGICKISDFGISRKSKDI-YSNSDM 1337 Query: 426 AVKGSFGYLDPE-------YYRRQS*PTVGCVLIRV 512 ++G+ ++ PE Y + ++GC+++ + Sbjct: 1338 TMRGTVFWMAPEMVDTKQGYSAKVDIWSLGCIVLEM 1373
>ARK1_SCHPO (O59790) Serine/threonine-protein kinase ark1 (EC 2.7.11.1)| (Aurora-related kinase 1) Length = 355 Score = 65.5 bits (158), Expect = 8e-11 Identities = 43/133 (32%), Positives = 68/133 (51%) Frame = +3 Query: 63 REFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYGSDMPPLGWKKR 242 ++ R EIE+ S LRH++++ L G+ ++ + L+ E+ +G L HL + + Sbjct: 132 KQVRREIEIQSNLRHKNILRLYGHFHDEKRIYLILEFAGRGELYQHLRRAKR--FSEEVA 189 Query: 243 VEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSKTGPELDQTHVS 422 + A L Y H K +IHRD+K NILL + K+SDFG S P ++ Sbjct: 190 SKYIFQMANALSYLH---KKHVIHRDIKPENILLGIDGEIKLSDFGWSVHAP----SNRR 242 Query: 423 TAVKGSFGYLDPE 461 T + G+ YL PE Sbjct: 243 TTLCGTLDYLPPE 255
>SRC_MOUSE (P05480) Neuronal proto-oncogene tyrosine-protein kinase Src (EC| 2.7.10.2) (p60-Src) (c-Src) (pp60c-src) Length = 540 Score = 65.5 bits (158), Expect = 8e-11 Identities = 43/126 (34%), Positives = 68/126 (53%) Frame = +3 Query: 12 STKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTL 191 +T+VA+K + F E +++ LRH LV L E+ + +V EYM KG+L Sbjct: 296 TTRVAIKT-LKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEE-PIYIVTEYMNKGSL 353 Query: 192 KSHLYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVS 371 L G L + V++ A G+ Y + +HRD+++ANIL+ ENL+ KV+ Sbjct: 354 LDFLKGETGKYLRLPQLVDMSAQIASGMAYVER---MNYVHRDLRAANILVGENLVCKVA 410 Query: 372 DFGLSK 389 DFGL++ Sbjct: 411 DFGLAR 416
>FPS_AVISP (P00541) Tyrosine-protein kinase transforming protein Fps (EC| 2.7.10.2) Length = 533 Score = 65.5 bits (158), Expect = 8e-11 Identities = 47/140 (33%), Positives = 73/140 (52%), Gaps = 1/140 (0%) Frame = +3 Query: 9 DSTKVAVKRGNQKSHQGLR-EFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKG 185 D+T VAVK + L+ +F E +L H ++V LIG C ++ + +V E ++ G Sbjct: 294 DNTPVAVKSCRETLPPELKAKFLQEARILKQYNHPNIVRLIGVCTQKQPIYIVMELVQGG 353 Query: 186 TLKSHLYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAK 365 S L S P L K+ +++ AA G+ Y + K IHRD+ + N L+ E K Sbjct: 354 DFLSFLR-SKGPHLKMKELIKMMENAAAGMEYLES---KHCIHRDLAARNCLVTEKNTLK 409 Query: 366 VSDFGLSKTGPELDQTHVST 425 +SDFG+S+ E D + ST Sbjct: 410 ISDFGMSR--QEEDGVYAST 427
>SRC_RSVH1 (P25020) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 65.5 bits (158), Expect = 8e-11 Identities = 43/126 (34%), Positives = 68/126 (53%) Frame = +3 Query: 12 STKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTL 191 +T+VA+K + F E +++ LRH LV L E+ + +V EYM KG+L Sbjct: 288 TTRVAIKT-LKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEE-PIYIVIEYMSKGSL 345 Query: 192 KSHLYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVS 371 L G L + V++ A G+ Y + +HRD+++ANIL+ ENL+ KV+ Sbjct: 346 LDFLKGEMGKYLRLPQLVDMAAQIASGMAYVER---MNYVHRDLRAANILVGENLVCKVA 402 Query: 372 DFGLSK 389 DFGL++ Sbjct: 403 DFGLAR 408
>TESK2_RAT (Q924U5) Dual specificity testis-specific protein kinase 2 (EC| 2.7.12.1) (Testicular protein kinase 2) Length = 570 Score = 65.5 bits (158), Expect = 8e-11 Identities = 48/138 (34%), Positives = 72/138 (52%), Gaps = 7/138 (5%) Frame = +3 Query: 78 EIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLK----SHLYGSDMPPLGWKKRV 245 E++L++ L H +++ +G C Q ++ + EY+ G L+ S+LY L W RV Sbjct: 101 EMQLMNRLSHPNILRFMGVCVHQGQLHALTEYINSGNLEQLLDSNLY------LPWTVRV 154 Query: 246 EICIGAARGLHYQHTGFAKSIIHRDVKSANILL--DEN-LMAKVSDFGLSKTGPELDQTH 416 ++ A GL Y H K I HRD+ S N L+ DEN A V+DFGL++ P+ Sbjct: 155 KLAYDIAVGLSYLH---FKGIFHRDLTSKNCLIKRDENGYSAVVADFGLAEKIPDASIGS 211 Query: 417 VSTAVKGSFGYLDPEYYR 470 AV GS ++ PE R Sbjct: 212 EKLAVVGSPFWMAPEVLR 229
>CLA4_CANAL (O14427) Serine/threonine-protein kinase CLA4 (EC 2.7.11.1)| Length = 971 Score = 65.5 bits (158), Expect = 8e-11 Identities = 44/157 (28%), Positives = 81/157 (51%), Gaps = 1/157 (0%) Frame = +3 Query: 9 DSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLI-GYCDEQNEMILVYEYMEKG 185 ++ K+A+K+ + + EI ++ +H+++V+ + Y NE+ ++ EYM+ G Sbjct: 703 NNRKIAIKQMDLDAQPRKELIINEILVMKDSQHKNIVNFLDSYLIGDNELWVIMEYMQGG 762 Query: 186 TLKSHLYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAK 365 +L + +D L K+ IC +GL + H K IIHRD+KS N+LLD K Sbjct: 763 SLTEIIENNDFK-LNEKQIATICFETLKGLQHLHK---KHIIHRDIKSDNVLLDAYGNVK 818 Query: 366 VSDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQ 476 ++DFG DQ + + G+ ++ PE +++ Sbjct: 819 ITDFGF--CAKLTDQRNKRATMVGTPYWMAPEVVKQK 853
>STK6_MOUSE (P97477) Serine/threonine-protein kinase 6 (EC 2.7.11.1)| (Aurora-family kinase 1) (Aurora/IPL1-related kinase 1) (Ipl1- and aurora-related kinase 1) (Aurora-A) (Serine/threonine-protein kinase Ayk1) Length = 395 Score = 65.5 bits (158), Expect = 8e-11 Identities = 42/132 (31%), Positives = 64/132 (48%) Frame = +3 Query: 66 EFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYGSDMPPLGWKKRV 245 + R E+E+ S LRH +++ L GY + + L+ EY GT+ L + ++ Sbjct: 168 QLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYREL--QKLSKFDEQRTA 225 Query: 246 EICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSKTGPELDQTHVST 425 A L Y H+ K +IHRD+K N+LL N K++DFG S P + T Sbjct: 226 TYITELANALSYCHS---KRVIHRDIKPENLLLGSNGELKIADFGWSVHAPSSRR----T 278 Query: 426 AVKGSFGYLDPE 461 + G+ YL PE Sbjct: 279 TMCGTLDYLPPE 290
>SRC_AVIST (P14085) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 556 Score = 65.1 bits (157), Expect = 1e-10 Identities = 43/126 (34%), Positives = 68/126 (53%) Frame = +3 Query: 12 STKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTL 191 +T+VA+K + F E +++ LRH LV L E+ + +V EYM KG+L Sbjct: 288 TTRVAIKT-LKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEE-PIYIVTEYMSKGSL 345 Query: 192 KSHLYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVS 371 L G L + V++ A G+ Y + +HRD+++ANIL+ ENL+ KV+ Sbjct: 346 LDFLKGEMGKYLRLPQLVDMAAQIASGMAYVER---MNYVHRDLRAANILVGENLVCKVA 402 Query: 372 DFGLSK 389 DFGL++ Sbjct: 403 DFGLAR 408
>SRC_CHICK (P00523) Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2)| (p60-Src) (c-Src) (pp60c-src) Length = 532 Score = 65.1 bits (157), Expect = 1e-10 Identities = 43/126 (34%), Positives = 68/126 (53%) Frame = +3 Query: 12 STKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTL 191 +T+VA+K + F E +++ LRH LV L E+ + +V EYM KG+L Sbjct: 288 TTRVAIKT-LKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEE-PIYIVTEYMSKGSL 345 Query: 192 KSHLYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVS 371 L G L + V++ A G+ Y + +HRD+++ANIL+ ENL+ KV+ Sbjct: 346 LDFLKGEMGKYLRLPQLVDMAAQIASGMAYVER---MNYVHRDLRAANILVGENLVCKVA 402 Query: 372 DFGLSK 389 DFGL++ Sbjct: 403 DFGLAR 408
>SRC_RSVSA (P00524) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 65.1 bits (157), Expect = 1e-10 Identities = 43/126 (34%), Positives = 68/126 (53%) Frame = +3 Query: 12 STKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTL 191 +T+VA+K + F E +++ LRH LV L E+ + +V EYM KG+L Sbjct: 288 TTRVAIKT-LKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEE-PIYIVTEYMSKGSL 345 Query: 192 KSHLYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVS 371 L G L + V++ A G+ Y + +HRD+++ANIL+ ENL+ KV+ Sbjct: 346 LDFLKGEMGKYLRLPQLVDMAAQIASGMAYVER---MNYVHRDLRAANILVGENLVCKVA 402 Query: 372 DFGLSK 389 DFGL++ Sbjct: 403 DFGLAR 408
>SRC_AVISR (P00525) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 65.1 bits (157), Expect = 1e-10 Identities = 43/126 (34%), Positives = 68/126 (53%) Frame = +3 Query: 12 STKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTL 191 +T+VA+K + F E +++ LRH LV L E+ + +V EYM KG+L Sbjct: 288 TTRVAIKT-LKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEE-PIYIVTEYMSKGSL 345 Query: 192 KSHLYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVS 371 L G L + V++ A G+ Y + +HRD+++ANIL+ ENL+ KV+ Sbjct: 346 LDFLKGEMGKYLRLPQLVDMAAQIASGMAYVER---MNYVHRDLRAANILVGENLVCKVA 402 Query: 372 DFGLSK 389 DFGL++ Sbjct: 403 DFGLAR 408
>MLTK_MOUSE (Q9ESL4) Mitogen-activated protein kinase kinase kinase MLT (EC| 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper-and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) ( Length = 802 Score = 65.1 bits (157), Expect = 1e-10 Identities = 43/153 (28%), Positives = 75/153 (49%) Frame = +3 Query: 3 LQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEK 182 + +VAVK+ L + E E+LS L HR+++ G E +V EY Sbjct: 36 ISQDKEVAVKK--------LLKIEKEAEILSVLSHRNIIQFYGVILEPPNYGIVTEYASL 87 Query: 183 GTLKSHLYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMA 362 G+L ++ + + + + A+G+HY H +IHRD+KS N+++ + + Sbjct: 88 GSLYDYINSNRSEEMDMEHIMTWATDVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVL 147 Query: 363 KVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPE 461 K+ DFG S+ TH+S + G+F ++ PE Sbjct: 148 KICDFGASRF--HNHTTHMS--LVGTFPWMAPE 176
>SRC_AVIS2 (P15054) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 586 Score = 65.1 bits (157), Expect = 1e-10 Identities = 43/126 (34%), Positives = 68/126 (53%) Frame = +3 Query: 12 STKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTL 191 +T+VA+K + F E +++ LRH LV L E+ + +V EYM KG+L Sbjct: 288 TTRVAIKT-LKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEE-PIYIVTEYMSKGSL 345 Query: 192 KSHLYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVS 371 L G L + V++ A G+ Y + +HRD+++ANIL+ ENL+ KV+ Sbjct: 346 LDFLKGEMGKYLRLPQLVDMAAQIASGMAYVER---MNYVHRDLRAANILVGENLVCKVA 402 Query: 372 DFGLSK 389 DFGL++ Sbjct: 403 DFGLAR 408
>SRK1_SPOLA (P42686) Tyrosine-protein kinase isoform SRK1 (EC 2.7.10.2)| Length = 505 Score = 65.1 bits (157), Expect = 1e-10 Identities = 47/151 (31%), Positives = 78/151 (51%), Gaps = 1/151 (0%) Frame = +3 Query: 12 STKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTL 191 +T VAVK + + EF E ++ LRH L+ L C ++ + +V E M+ G+L Sbjct: 262 TTSVAVKT-LKPGTMSVEEFLQEASIMKRLRHPKLIQLYAVCTKEEPIYIVTELMKYGSL 320 Query: 192 KSHLYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVS 371 +L G D L ++ V++ A G+ Y ++ IHRD+ + NIL+ E+ + KV+ Sbjct: 321 LEYLRGED-GVLKIEQLVDVAAQVASGMSYLE---QQNYIHRDLAARNILVGEHGICKVA 376 Query: 372 DFGLSKT-GPELDQTHVSTAVKGSFGYLDPE 461 DFGL++ E+ + H T K + PE Sbjct: 377 DFGLARVIDEEIYEAH--TGAKFPIKWTAPE 405
>SRC_RAT (Q9WUD9) Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2)| (p60-Src) (c-Src) (pp60c-src) Length = 535 Score = 65.1 bits (157), Expect = 1e-10 Identities = 43/126 (34%), Positives = 68/126 (53%) Frame = +3 Query: 12 STKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTL 191 +T+VA+K + F E +++ LRH LV L E+ + +V EYM KG+L Sbjct: 291 TTRVAIKT-LKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEE-PIYIVTEYMNKGSL 348 Query: 192 KSHLYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVS 371 L G L + V++ A G+ Y + +HRD+++ANIL+ ENL+ KV+ Sbjct: 349 LDFLKGETGKYLRLPQLVDMSAQIASGMAYVDR---MNYVHRDLRAANILVGENLVCKVA 405 Query: 372 DFGLSK 389 DFGL++ Sbjct: 406 DFGLAR 411
>ANKK1_HUMAN (Q8NFD2) Ankyrin repeat and protein kinase domain-containing| protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (X-kinase) (SgK288) Length = 765 Score = 64.7 bits (156), Expect = 1e-10 Identities = 40/132 (30%), Positives = 69/132 (52%), Gaps = 2/132 (1%) Frame = +3 Query: 78 EIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYGSDMPPLGWKKRVEICI 257 E + ++ +H+VS+ G C + + +V E+M G+L+ L L WK R I Sbjct: 71 EAAKMKKIKFQHIVSIYGVCKQP--LGIVMEFMANGSLEKVL---STHSLCWKLRFRIIH 125 Query: 258 GAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSKTGPELDQTHV--STAV 431 + +++ H+ ++H D+K NILLD N+ K+SDFGLSK + + +A+ Sbjct: 126 ETSLAMNFLHS-IKPPLLHLDLKPGNILLDSNMHVKISDFGLSKWMEQSTRMQYIERSAL 184 Query: 432 KGSFGYLDPEYY 467 +G Y+ PE + Sbjct: 185 RGMLSYIPPEMF 196
>SRC_AVISS (P14084) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 567 Score = 64.7 bits (156), Expect = 1e-10 Identities = 43/126 (34%), Positives = 68/126 (53%) Frame = +3 Query: 12 STKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTL 191 +T+VA+K + F E +++ LRH LV L E+ + +V EYM KG+L Sbjct: 288 TTRVAIKT-LKPGTMSPEAFLQEAQVMKKLRHEKLVRLYAVVSEE-PIYIVTEYMSKGSL 345 Query: 192 KSHLYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVS 371 L G L + V++ A G+ Y + +HRD+++ANIL+ ENL+ KV+ Sbjct: 346 LDFLKGEMGKYLRLPQLVDMAAQIASGMAYVER---MNYVHRDLRAANILVGENLVCKVA 402 Query: 372 DFGLSK 389 DFGL++ Sbjct: 403 DFGLAR 408
>SRC2_XENLA (P13116) Tyrosine-protein kinase Src-2 (EC 2.7.10.2) (p60-Src-2)| Length = 531 Score = 64.7 bits (156), Expect = 1e-10 Identities = 43/126 (34%), Positives = 68/126 (53%) Frame = +3 Query: 12 STKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTL 191 +T+VA+K + F E +++ LRH LV L E+ + +V EYM KG+L Sbjct: 287 TTRVAIKT-LKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEE-PIYIVTEYMSKGSL 344 Query: 192 KSHLYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVS 371 L G L + V++ A G+ Y + +HRD+++ANIL+ ENL+ KV+ Sbjct: 345 LDFLKGEMGRYLRLPQLVDMAAQIASGMAYVER---MNYVHRDLRAANILVGENLVCKVA 401 Query: 372 DFGLSK 389 DFGL++ Sbjct: 402 DFGLAR 407
>PKNB_MYCLE (P54744) Probable serine/threonine-protein kinase pknB (EC| 2.7.11.1) Length = 622 Score = 64.7 bits (156), Expect = 1e-10 Identities = 47/159 (29%), Positives = 77/159 (48%), Gaps = 11/159 (6%) Frame = +3 Query: 69 FRTEIELLSGLRHRHLVSLIGYCDEQNEM----ILVYEYMEKGTLKSHLY-GSDMPPLGW 233 FR E + + L H +V++ + + +V EY++ TL+ ++ MPP Sbjct: 56 FRREAQNAAALNHPSIVAVYDTGEAETSAGPLPYIVMEYVDGATLRDIVHTDGPMPP--- 112 Query: 234 KKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSKTGPELDQT 413 ++ +EI A + L++ H IIHRDVK ANI++ KV DFG+++ + Sbjct: 113 QQAIEIVADACQALNFSHQN---GIIHRDVKPANIMISATNAVKVMDFGIARAIADSTSV 169 Query: 414 HVSTAVKGSFGYLDPEYYR------RQS*PTVGCVLIRV 512 + AV G+ YL PE R R ++GCVL + Sbjct: 170 TQTAAVIGTAQYLSPEQARGDSVDARSDVYSLGCVLYEI 208
>IPL1_YARLI (Q6C3J2) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) Length = 371 Score = 64.3 bits (155), Expect = 2e-10 Identities = 45/138 (32%), Positives = 70/138 (50%), Gaps = 5/138 (3%) Frame = +3 Query: 63 REFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYGSDMPPLGWKKR 242 ++FR E+E+ S LRH +++ L G+ +++ + L+ EY+ G L L K+ Sbjct: 142 KQFRREVEIQSNLRHTNVLRLFGHFHDKDRVYLILEYVVHGELYKLLRNQ-------KRF 194 Query: 243 VEICIGA-----ARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSKTGPELD 407 E + + L Y H K+IIHRD+K NILL N K+SDFG S P Sbjct: 195 TESTASSYIYQMSEALLYLH---GKNIIHRDIKPENILLHFNDTIKISDFGWSVHAP--- 248 Query: 408 QTHVSTAVKGSFGYLDPE 461 ++ + + G+ YL PE Sbjct: 249 -SNRRSTLCGTMDYLPPE 265
>INSR_MOUSE (P15208) Insulin receptor precursor (EC 2.7.10.1) (IR) [Contains:| Insulin receptor alpha subunit; Insulin receptor beta subunit] Length = 1372 Score = 64.3 bits (155), Expect = 2e-10 Identities = 42/140 (30%), Positives = 69/140 (49%), Gaps = 9/140 (6%) Frame = +3 Query: 15 TKVAVKRGNQKSHQGLR-EFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTL 191 T+VAVK N+ + R EF E ++ G H+V L+G + M++V E M G L Sbjct: 1042 TRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPMLVVMELMAHGDL 1101 Query: 192 KSHL--------YGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLD 347 KSHL PP ++ +++ A G+ Y + AK +HRD+ + N ++ Sbjct: 1102 KSHLRSLRPDAENNPGRPPPTLQEMIQMTAEIADGMAYLN---AKKFVHRDLAARNCMVA 1158 Query: 348 ENLMAKVSDFGLSKTGPELD 407 + K+ DFG+++ E D Sbjct: 1159 HDFTVKIGDFGMTRDIYETD 1178
>PTK7_HUMAN (Q13308) Tyrosine-protein kinase-like 7 precursor (Colon carcinoma| kinase 4) (CCK-4) Length = 1070 Score = 64.3 bits (155), Expect = 2e-10 Identities = 44/133 (33%), Positives = 63/133 (47%), Gaps = 8/133 (6%) Frame = +3 Query: 15 TKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLK 194 T V VK K Q +FR E+E+ L H ++V L+G C E +V EY++ LK Sbjct: 825 TLVLVKSLQSKDEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLEDLK 884 Query: 195 SHLYGS-------DMPPLGWKKRVEICIGAARGL-HYQHTGFAKSIIHRDVKSANILLDE 350 L S PL K++V +C A G+ H + F +H+D+ + N L+ Sbjct: 885 QFLRISKSKDEKLKSQPLSTKQKVALCTQVALGMEHLSNNRF----VHKDLAARNCLVSA 940 Query: 351 NLMAKVSDFGLSK 389 KVS GLSK Sbjct: 941 QRQVKVSALGLSK 953
>EPHA1_MOUSE (Q60750) Ephrin type-A receptor 1 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ESK) Length = 977 Score = 64.3 bits (155), Expect = 2e-10 Identities = 44/153 (28%), Positives = 76/153 (49%), Gaps = 1/153 (0%) Frame = +3 Query: 6 QDSTKVAVKRGNQKSHQGLR-EFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEK 182 QD VA+K S G F E ++ H H++ L G ++ ++++ E+ME Sbjct: 649 QDCKTVAIKTLKDTSPDGYWWNFLREATIMGQFNHPHILRLEGVITKRKPIMIITEFMEN 708 Query: 183 GTLKSHLYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMA 362 G L + L + L + V + +G A G++ + +HRD+ + NIL+++NL Sbjct: 709 GALDAFLKERE-DQLAPGQLVAMLLGIASGMNCLS---GHNYVHRDLAARNILVNQNLCC 764 Query: 363 KVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPE 461 KVSDFGL++ + D T+ + K + PE Sbjct: 765 KVSDFGLTRLLDDFDGTYETQGGKIPIRWTAPE 797
>TNI3K_HUMAN (Q59H18) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 936 Score = 64.3 bits (155), Expect = 2e-10 Identities = 46/153 (30%), Positives = 82/153 (53%), Gaps = 4/153 (2%) Frame = +3 Query: 21 VAVKRGNQKSHQGLRE---FRTEIELLSGLRHRHLVSLIGYC-DEQNEMILVYEYMEKGT 188 VA+KR ++ + F E+ +L L H ++ +G C ++ ++ +V +Y+ G+ Sbjct: 588 VAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVIQFVGACLNDPSQFAIVTQYISGGS 647 Query: 189 LKSHLYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKV 368 L S L+ L + ++ I + A+G+ Y H + IIHRD+ S NILL E+ A V Sbjct: 648 LFSLLH-EQKRILDLQSKLIIAVDVAKGMEYLHN-LTQPIIHRDLNSHNILLYEDGHAVV 705 Query: 369 SDFGLSKTGPELDQTHVSTAVKGSFGYLDPEYY 467 +DFG S+ LD+ ++ T G+ ++ PE + Sbjct: 706 ADFGESRFLQSLDEDNM-TKQPGNLRWMAPEVF 737
>MLTK_HUMAN (Q9NYL2) Mitogen-activated protein kinase kinase kinase MLT (EC| 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper-and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase Length = 800 Score = 64.3 bits (155), Expect = 2e-10 Identities = 43/153 (28%), Positives = 74/153 (48%) Frame = +3 Query: 3 LQDSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEK 182 + +VAVK+ L + E E+LS L HR+++ G E +V EY Sbjct: 36 ISQDKEVAVKK--------LLKIEKEAEILSVLSHRNIIQFYGVILEPPNYGIVTEYASL 87 Query: 183 GTLKSHLYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMA 362 G+L ++ + + + A+G+HY H +IHRD+KS N+++ + + Sbjct: 88 GSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVL 147 Query: 363 KVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPE 461 K+ DFG S+ TH+S + G+F ++ PE Sbjct: 148 KICDFGASRF--HNHTTHMS--LVGTFPWMAPE 176
>FGFR4_RAT (Q498D6) Fibroblast growth factor receptor 4 precursor (EC| 2.7.10.1) (FGFR-4) Length = 800 Score = 64.3 bits (155), Expect = 2e-10 Identities = 39/149 (26%), Positives = 74/149 (49%), Gaps = 15/149 (10%) Frame = +3 Query: 6 QDSTKVAVKRGNQKSHQGLREFRTEIELLSGL-RHRHLVSLIGYCDEQNEMILVYEYMEK 182 Q ST + S + L + +E+E++ + RH+++++L+G C ++ + ++ EY K Sbjct: 494 QTSTVAVKMLKDNASDKDLADLISEMEMMKLIGRHKNIINLLGVCTQEGPLYVIVEYAAK 553 Query: 183 GTLKSHLYGSDMP--------------PLGWKKRVEICIGAARGLHYQHTGFAKSIIHRD 320 G L+ L P PL + V ARG+ Y ++ IHRD Sbjct: 554 GNLREFLRARRPPGPDLSPDGPRSSEGPLSFPALVSCAYQVARGMQYLE---SRKCIHRD 610 Query: 321 VKSANILLDENLMAKVSDFGLSKTGPELD 407 + + N+L+ E+ + K++DFGL++ +D Sbjct: 611 LAARNVLVTEDDVMKIADFGLARGVHHID 639
>ANKK1_MOUSE (Q8BZ25) Ankyrin repeat and protein kinase domain-containing| protein 1 (EC 2.7.11.1) Length = 745 Score = 63.9 bits (154), Expect = 2e-10 Identities = 38/125 (30%), Positives = 68/125 (54%), Gaps = 2/125 (1%) Frame = +3 Query: 99 LRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYGSDMPPLGWKKRVEICIGAARGLH 278 ++ +H+VS+ G C + + +V E+M G+L+ L L W ++ I + ++ Sbjct: 90 IKFQHIVSIYGVCKQP--LGIVMEFMASGSLEKTL---PTHSLCWPLKLRIIHETSLAMN 144 Query: 279 YQHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSKTGPELDQTHV--STAVKGSFGYL 452 + H+ ++H D+K NILLD N+ K+SDFGLSK + Q +A++G+ Y+ Sbjct: 145 FLHS-IKPPLLHLDLKPGNILLDNNMHVKISDFGLSKWMEQSTQKQYIERSALRGTLSYI 203 Query: 453 DPEYY 467 PE + Sbjct: 204 PPEMF 208
>SRMS_HUMAN (Q9H3Y6) Tyrosine-protein kinase Srms (EC 2.7.10.2)| Length = 488 Score = 63.9 bits (154), Expect = 2e-10 Identities = 38/121 (31%), Positives = 60/121 (49%) Frame = +3 Query: 27 VKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLY 206 +K N K L + EI+ L GLRH L+ L C + +V E M KG L++ L Sbjct: 260 IKSANMK----LTDLAKEIQTLKGLRHERLIRLHAVCSGGEPVYIVTELMRKGNLQAFLG 315 Query: 207 GSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLS 386 + L + A G+ Y + ++HRD+ + N+L+D+ L KV+DFGL+ Sbjct: 316 TPEGRALRLPPLLGFACQVAEGMSYLEE---QRVVHRDLAARNVLVDDGLACKVADFGLA 372 Query: 387 K 389 + Sbjct: 373 R 373
>TSSK4_HUMAN (Q6SA08) Testis-specific serine/threonine-protein kinase 4 (EC| 2.7.11.1) (TSSK-4) (Testis-specific kinase 4) (TSK-4) (Serine/threonine-protein kinase 22E) Length = 328 Score = 63.9 bits (154), Expect = 2e-10 Identities = 44/146 (30%), Positives = 72/146 (49%), Gaps = 15/146 (10%) Frame = +3 Query: 78 EIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHL--YGSDMPPLGWKKRVEI 251 EI+++ LRH++L++ + + + ++ E + G + + YG+ PL K ++ Sbjct: 73 EIQVMKVLRHKYLINFYRAIESTSRVYIILELAQGGDVLEWIQRYGACSEPLAGKWFSQL 132 Query: 252 CIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSKTGPELDQ------- 410 +G A Y H+ KSI+HRD+K N+LLD+ K+SDFG +K P Sbjct: 133 TLGIA----YLHS---KSIVHRDLKLENLLLDKWENVKISDFGFAKMVPSNQPVGCSPSY 185 Query: 411 ------THVSTAVKGSFGYLDPEYYR 470 +H+S GSF Y PE R Sbjct: 186 RQVNCFSHLSQTYCGSFAYACPEILR 211
>FLK_RAT (P09760) Tyrosine-protein kinase FLK (EC 2.7.10.2) (Fragment)| Length = 323 Score = 63.5 bits (153), Expect = 3e-10 Identities = 43/130 (33%), Positives = 67/130 (51%), Gaps = 1/130 (0%) Frame = +3 Query: 3 LQDSTKVAVKRGNQKSHQGLR-EFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYME 179 L+D T VAVK + Q L+ +F E ++L H ++V LIG C ++ + ++ E + Sbjct: 83 LKDKTPVAVKTCKEDLPQELKIKFLQEAKILKQYDHPNIVKLIGVCTQRQPVYIIMELVP 142 Query: 180 KGTLKSHLYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLM 359 G S L L K+ V + A G+ Y K+ IHRD+ + N L+ EN Sbjct: 143 GGDFLSFLR-KRKDELKLKQLVRFSLDVAAGMLYLE---GKNCIHRDLAARNCLVGENNT 198 Query: 360 AKVSDFGLSK 389 K+SDFG+S+ Sbjct: 199 LKISDFGMSR 208
>VAB1_CAEEL (O61460) Ephrin receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein| kinase Eph receptor) (Variable abnormal protein 1) Length = 1122 Score = 63.5 bits (153), Expect = 3e-10 Identities = 37/112 (33%), Positives = 59/112 (52%), Gaps = 4/112 (3%) Frame = +3 Query: 66 EFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYGSDM--PPLGWKK 239 EF TE ++ H +++ LIG +++V EYM G+L L +D + W+K Sbjct: 761 EFLTEATIMGQFSHPNVIRLIGVVTSAEPVMIVAEYMANGSLDQFLRNTDQRGEKVHWEK 820 Query: 240 RVEICIGAARGLHY-QHTGFAKSI-IHRDVKSANILLDENLMAKVSDFGLSK 389 E+ G A G+ Y G+ + RD+ + N+LLD L K++DFGLS+ Sbjct: 821 ITEMLYGIASGMKYLTDMGYVHRVSFLRDLAARNVLLDMELRCKIADFGLSR 872
>FYN_XENLA (P13406) Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2)| (p59-Fyn) Length = 536 Score = 63.5 bits (153), Expect = 3e-10 Identities = 42/126 (33%), Positives = 66/126 (52%) Frame = +3 Query: 12 STKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTL 191 +TKVA+K + F E +++ L+H LV L E+ + +V EYM KG+L Sbjct: 292 NTKVAIKT-LKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEE-PIYIVTEYMSKGSL 349 Query: 192 KSHLYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVS 371 L + L V++ ARG+ Y + IHRD++SANIL+ L+ K++ Sbjct: 350 LDFLKDGEGRALKLPNLVDMAAQVARGMAYIER---MNYIHRDLRSANILVGNGLICKIA 406 Query: 372 DFGLSK 389 DFGL++ Sbjct: 407 DFGLAR 412
>IPL1_YEAST (P38991) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) (Increase-in-ploidy protein 1) Length = 367 Score = 63.5 bits (153), Expect = 3e-10 Identities = 43/135 (31%), Positives = 66/135 (48%), Gaps = 2/135 (1%) Frame = +3 Query: 63 REFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKS--HLYGSDMPPLGWK 236 ++FR E+E+ + L H +L GY ++ + L+ EY+ G + L+G P Sbjct: 147 KQFRREVEIQTSLNHPNLTKSYGYFHDEKRVYLLMEYLVNGEMYKLLRLHG----PFNDI 202 Query: 237 KRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSKTGPELDQTH 416 + A L Y H K+IIHRD+K NIL+ N + K++DFG S P ++ Sbjct: 203 LASDYIYQIANALDYMHK---KNIIHRDIKPENILIGFNNVIKLTDFGWSIINPPENR-- 257 Query: 417 VSTAVKGSFGYLDPE 461 V G+ YL PE Sbjct: 258 -RKTVCGTIDYLSPE 271
>ARAF_HUMAN (P10398) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (A-raf-1) (Proto-oncogene Pks) Length = 606 Score = 63.2 bits (152), Expect = 4e-10 Identities = 43/152 (28%), Positives = 75/152 (49%) Frame = +3 Query: 21 VAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSH 200 V V + +Q + + + F+ E+++L RH +++ +G+ I+ ++ E +L H Sbjct: 335 VKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIIT-QWCEGSSLYHH 393 Query: 201 LYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDFG 380 L+ +D + +++ A+G+ Y H AK+IIHRD+KS NI L E L K+ DFG Sbjct: 394 LHVADTR-FDMVQLIDVARQTAQGMDYLH---AKNIIHRDLKSNNIFLHEGLTVKIGDFG 449 Query: 381 LSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQ 476 L+ GS ++ E R Q Sbjct: 450 LATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQ 481
>EPHA1_HUMAN (P21709) Ephrin type-A receptor 1 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EPH) Length = 976 Score = 63.2 bits (152), Expect = 4e-10 Identities = 45/153 (29%), Positives = 76/153 (49%), Gaps = 1/153 (0%) Frame = +3 Query: 6 QDSTKVAVKRGNQKSHQGLR-EFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEK 182 QD VA+K S G F E ++ H H++ L G ++ ++++ E+ME Sbjct: 648 QDCKTVAIKTLKDTSPGGQWWNFLREATIMGQFSHPHILHLEGVVTKRKPIMIITEFMEN 707 Query: 183 GTLKSHLYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMA 362 G L + L + L + V + G A G++Y + +HRD+ + NIL+++NL Sbjct: 708 GALDAFLRERE-DQLVPGQLVAMLQGIASGMNYLSN---HNYVHRDLAARNILVNQNLCC 763 Query: 363 KVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPE 461 KVSDFGL++ + D T+ + K + PE Sbjct: 764 KVSDFGLTRLLDDFDGTYETQGGKIPIRWTAPE 796
>STK6_RAT (P59241) Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Aurora-A)| (ratAurA) Length = 397 Score = 63.2 bits (152), Expect = 4e-10 Identities = 41/132 (31%), Positives = 63/132 (47%) Frame = +3 Query: 66 EFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYGSDMPPLGWKKRV 245 + R E+E+ S LRH +++ L GY + + L+ EY GT+ L + ++ Sbjct: 170 QLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYREL--QKLSKFDEQRTA 227 Query: 246 EICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSKTGPELDQTHVST 425 A L Y H+ K +IHRD+K N+LL N K++DFG S P + T Sbjct: 228 TYITELANALSYCHS---KRVIHRDIKPENLLLGSNGELKIADFGWSVHAPSSRR----T 280 Query: 426 AVKGSFGYLDPE 461 + G+ Y PE Sbjct: 281 TLCGTLDYQPPE 292
>STK36_PONPY (Q5RAJ5) Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused| homolog) Length = 1315 Score = 63.2 bits (152), Expect = 4e-10 Identities = 49/159 (30%), Positives = 81/159 (50%), Gaps = 6/159 (3%) Frame = +3 Query: 45 KSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYGSDMPP 224 +S + LR + EIE++ GLRH ++V ++ + E+++V +Y E G L L P Sbjct: 40 RSEKELRNLQREIEIMRGLRHPNIVHMLDSFETDKEVVVVTDYAE-GELLQILEDDGKLP 98 Query: 225 LGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSKTGPEL 404 + + + +A L+Y H + I+HRD+K NILL + K+ DFG ++ Sbjct: 99 EDQVQAIAAQLVSA--LYYLH---SHRILHRDMKPQNILLAKGGGIKLCDFGFARA--MS 151 Query: 405 DQTHVSTAVKGSFGYLDPE------YYRRQS*PTVGCVL 503 T V T++KG+ Y+ PE Y +VGC+L Sbjct: 152 TNTMVLTSIKGTPLYMSPELVEERPYDHTADLWSVGCIL 190
>M3KL4_HUMAN (Q5TCX8) Mitogen-activated protein kinase kinase kinase (EC| 2.7.11.25) (Mixed lineage kinase 4) Length = 1036 Score = 63.2 bits (152), Expect = 4e-10 Identities = 53/172 (30%), Positives = 78/172 (45%), Gaps = 24/172 (13%) Frame = +3 Query: 18 KVAVKRGNQKSHQ----GLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKG 185 +VAVK Q Q R E L + LRH +++ L G C +Q + LV E+ G Sbjct: 147 EVAVKAARQDPEQDAAAAAESVRREARLFAMLRHPNIIELRGVCLQQPHLCLVLEFARGG 206 Query: 186 TLKSHLYGSDMPP------------LGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKS 329 L L ++ P + V + ARG+ Y H I+HRD+KS Sbjct: 207 ALNRALAAANAAPDPRAPGPRRARRIPPHVLVNWAVQIARGMLYLHEEAFVPILHRDLKS 266 Query: 330 ANILLDE--------NLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPE 461 +NILL E N K++DFGL++ T +STA G++ ++ PE Sbjct: 267 SNILLLEKIEHDDICNKTLKITDFGLAREWHR--TTKMSTA--GTYAWMAPE 314
>SRC1_XENLA (P13115) Tyrosine-protein kinase Src-1 (EC 2.7.10.2) (p60-Src-1)| Length = 531 Score = 63.2 bits (152), Expect = 4e-10 Identities = 42/126 (33%), Positives = 68/126 (53%) Frame = +3 Query: 12 STKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTL 191 +T+VA+K + F E +++ LRH LV L E+ + +V EY+ KG+L Sbjct: 287 TTRVAIKT-LKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEE-PIYIVTEYISKGSL 344 Query: 192 KSHLYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVS 371 L G L + V++ A G+ Y + +HRD+++ANIL+ ENL+ KV+ Sbjct: 345 LDFLKGEMGRYLRLPQLVDMAAQIASGMAYVER---MNYVHRDLRAANILVGENLVCKVA 401 Query: 372 DFGLSK 389 DFGL++ Sbjct: 402 DFGLAR 407
>YES_MOUSE (Q04736) Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2)| (p61-Yes) (c-Yes) Length = 540 Score = 62.8 bits (151), Expect = 5e-10 Identities = 43/126 (34%), Positives = 68/126 (53%) Frame = +3 Query: 12 STKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTL 191 +TKVA+K + F E +++ LRH LV L E+ + +V E+M KG+L Sbjct: 296 TTKVAIKTLKPGTMMP-EAFLQEAQIMKKLRHDKLVPLYAVVSEE-PIYIVTEFMSKGSL 353 Query: 192 KSHLYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVS 371 L D L + V++ A G+ Y + IHRD+++ANIL+ ENL+ K++ Sbjct: 354 LDFLKEGDGKYLKLPQLVDMAAQIADGMAYIER---MNYIHRDLRAANILVGENLICKIA 410 Query: 372 DFGLSK 389 DFGL++ Sbjct: 411 DFGLAR 416
>ABL1_CAEEL (P03949) Tyrosine-protein kinase abl-1 (EC 2.7.10.2)| Length = 1224 Score = 62.8 bits (151), Expect = 5e-10 Identities = 35/110 (31%), Positives = 59/110 (53%) Frame = +3 Query: 60 LREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYGSDMPPLGWKK 239 L EF E ++ L H++LV L+G C + ++ E+M G L +L +D L Sbjct: 349 LHEFLAEAAIMKDLHHKNLVRLLGVCTHEAPFYIITEFMCNGNLLEYLRRTDKSLLPPII 408 Query: 240 RVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSK 389 V++ A G+ Y A+ IHRD+ + N L+ E+ + K++DFGL++ Sbjct: 409 LVQMASQIASGMSYLE---ARHFIHRDLAARNCLVSEHNIVKIADFGLAR 455
>M3K13_PONPY (Q5R8X7) Mitogen-activated protein kinase kinase kinase 13 (EC| 2.7.11.25) Length = 966 Score = 62.8 bits (151), Expect = 5e-10 Identities = 46/154 (29%), Positives = 75/154 (48%), Gaps = 1/154 (0%) Frame = +3 Query: 18 KVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKS 197 +VA+K+ +++ T+I+ L L+H ++++ G C + ++ EY G L Sbjct: 191 EVAIKKVREQNE-------TDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYE 243 Query: 198 HLY-GSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSD 374 L G + P + V+ G A G++Y H IIHRD+KS N+L+ K+SD Sbjct: 244 VLRAGRKITP---RLLVDWSTGIASGMNYLHL---HKIIHRDLKSPNVLVTHTDAVKISD 297 Query: 375 FGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQ 476 FG SK EL + G+ +L PE R + Sbjct: 298 FGTSK---ELSDKSTKMSFAGTVAWLAPEVIRNE 328
>YES_HUMAN (P07947) Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2)| (p61-Yes) (c-Yes) Length = 542 Score = 62.8 bits (151), Expect = 5e-10 Identities = 43/126 (34%), Positives = 68/126 (53%) Frame = +3 Query: 12 STKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTL 191 +TKVA+K + F E +++ LRH LV L E+ + +V E+M KG+L Sbjct: 298 TTKVAIKTLKPGTMMP-EAFLQEAQIMKKLRHDKLVPLYAVVSEE-PIYIVTEFMSKGSL 355 Query: 192 KSHLYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVS 371 L D L + V++ A G+ Y + IHRD+++ANIL+ ENL+ K++ Sbjct: 356 LDFLKEGDGKYLKLPQLVDMAAQIADGMAYIER---MNYIHRDLRAANILVGENLVCKIA 412 Query: 372 DFGLSK 389 DFGL++ Sbjct: 413 DFGLAR 418
>CEK3_CHICK (P18461) Tyrosine kinase receptor CEK3 precursor (EC 2.7.10.1)| Length = 823 Score = 62.8 bits (151), Expect = 5e-10 Identities = 41/168 (24%), Positives = 85/168 (50%), Gaps = 16/168 (9%) Frame = +3 Query: 6 QDSTKVAVKR-GNQKSHQGLREFRTEIELLSGL-RHRHLVSLIGYCDEQNEMILVYEYME 179 +++ VAVK + + + L + +E+E++ + +H+++++L+G C + + ++ EY Sbjct: 511 KEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYAS 570 Query: 180 KGTLKSHLYGSDMPPLGW--------------KKRVEICIGAARGLHYQHTGFAKSIIHR 317 KG L+ +L P + + K V ARG+ Y + + IHR Sbjct: 571 KGNLREYLRARRPPGMEYSFDINRVPEEQMTFKDLVSCTYQLARGMEYLAS---QKCIHR 627 Query: 318 DVKSANILLDENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPE 461 D+ + N+L+ EN + K++DFGL++ +D +T + ++ PE Sbjct: 628 DLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPE 675
>CDC15_YEAST (P27636) Cell division control protein 15 (EC 2.7.11.1)| Length = 974 Score = 62.8 bits (151), Expect = 5e-10 Identities = 38/122 (31%), Positives = 61/122 (50%) Frame = +3 Query: 21 VAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSH 200 VA+K ++ + L + EI LL L H ++V G+ + E+ ++ EY G+L+ Sbjct: 51 VAIKEVVYENDEELNDIMAEISLLKNLNHNNIVKYHGFIRKSYELYILLEYCANGSLR-R 109 Query: 201 LYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDFG 380 L L + GL Y H + +IHRD+K+ANILL + K++DFG Sbjct: 110 LISRSSTGLSENESKTYVTQTLLGLKYLH---GEGVIHRDIKAANILLSADNTVKLADFG 166 Query: 381 LS 386 +S Sbjct: 167 VS 168
>STK36_HUMAN (Q9NRP7) Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused| homolog) Length = 1315 Score = 62.8 bits (151), Expect = 5e-10 Identities = 49/159 (30%), Positives = 81/159 (50%), Gaps = 6/159 (3%) Frame = +3 Query: 45 KSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYGSDMPP 224 +S + LR + EIE++ GLRH ++V ++ + E+++V +Y E G L L P Sbjct: 40 RSEKELRNLQREIEIMRGLRHPNIVHMLDSFETDKEVVVVTDYAE-GELFQILEDDGKLP 98 Query: 225 LGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSKTGPEL 404 + + + +A L+Y H + I+HRD+K NILL + K+ DFG ++ Sbjct: 99 EDQVQAIAAQLVSA--LYYLH---SHRILHRDMKPQNILLAKGGGIKLCDFGFARA--MS 151 Query: 405 DQTHVSTAVKGSFGYLDPE------YYRRQS*PTVGCVL 503 T V T++KG+ Y+ PE Y +VGC+L Sbjct: 152 TNTMVLTSIKGTPLYMSPELVEERPYDHTADLWSVGCIL 190
>FGFR2_MOUSE (P21803) Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1)| (FGFR-2) (Keratinocyte growth factor receptor) Length = 821 Score = 62.8 bits (151), Expect = 5e-10 Identities = 41/168 (24%), Positives = 85/168 (50%), Gaps = 16/168 (9%) Frame = +3 Query: 6 QDSTKVAVKR-GNQKSHQGLREFRTEIELLSGL-RHRHLVSLIGYCDEQNEMILVYEYME 179 +++ VAVK + + + L + +E+E++ + +H+++++L+G C + + ++ EY Sbjct: 509 KEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYAS 568 Query: 180 KGTLKSHLYGSDMPPLGW--------------KKRVEICIGAARGLHYQHTGFAKSIIHR 317 KG L+ +L P + + K V ARG+ Y + + IHR Sbjct: 569 KGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLAS---QKCIHR 625 Query: 318 DVKSANILLDENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPE 461 D+ + N+L+ EN + K++DFGL++ +D +T + ++ PE Sbjct: 626 DLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPE 673
>FGFR2_HUMAN (P21802) Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1)| (FGFR-2) (Keratinocyte growth factor receptor 2) (CD332 antigen) Length = 821 Score = 62.8 bits (151), Expect = 5e-10 Identities = 41/168 (24%), Positives = 85/168 (50%), Gaps = 16/168 (9%) Frame = +3 Query: 6 QDSTKVAVKR-GNQKSHQGLREFRTEIELLSGL-RHRHLVSLIGYCDEQNEMILVYEYME 179 +++ VAVK + + + L + +E+E++ + +H+++++L+G C + + ++ EY Sbjct: 509 KEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYAS 568 Query: 180 KGTLKSHLYGSDMPPLGW--------------KKRVEICIGAARGLHYQHTGFAKSIIHR 317 KG L+ +L P + + K V ARG+ Y + + IHR Sbjct: 569 KGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLAS---QKCIHR 625 Query: 318 DVKSANILLDENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPE 461 D+ + N+L+ EN + K++DFGL++ +D +T + ++ PE Sbjct: 626 DLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPE 673
>PKN1_THETN (Q8R9T6) Probable serine/threonine-protein kinase Sps1 (EC| 2.7.11.1) Length = 625 Score = 62.8 bits (151), Expect = 5e-10 Identities = 41/134 (30%), Positives = 68/134 (50%) Frame = +3 Query: 60 LREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYGSDMPPLGWKK 239 +++F+ E + + L H ++V + E + +V EY++ TLK L + PL K+ Sbjct: 52 VKKFKRESQAAASLSHPNIVGIYDVGQEGDIYYIVMEYVKGRTLKE-LIRENGGPLEVKR 110 Query: 240 RVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSKTGPELDQTHV 419 VEI R L + H IIHRD+K NIL+ + + KV+DFG+++ T+ Sbjct: 111 AVEIASQVCRALDHAHKN---KIIHRDIKPQNILVTDEDVVKVTDFGIARAANGATITYT 167 Query: 420 STAVKGSFGYLDPE 461 + G+ Y PE Sbjct: 168 GDVI-GTAYYFSPE 180
>PHKG2_MOUSE (Q9DB30) Phosphorylase b kinase gamma catalytic chain, testis/liver| isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase gamma subunit 2) Length = 406 Score = 62.4 bits (150), Expect = 7e-10 Identities = 43/131 (32%), Positives = 69/131 (52%), Gaps = 1/131 (0%) Frame = +3 Query: 72 RTEIELLSGLR-HRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYGSDMPPLGWKKRVE 248 R E+ +L + H H+++LI + + M LV++ M KG L +L ++ L K+ Sbjct: 75 RREMHILRQVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYL--TEKVALSEKETRS 132 Query: 249 ICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSKTGPELDQTHVSTA 428 I + + H A +I+HRD+K NILLD+N+ ++SDFG S L+ Sbjct: 133 IMRSLLEAVSFLH---ANNIVHRDLKPENILLDDNMQIRLSDFGFS---CHLEAGEKLRE 186 Query: 429 VKGSFGYLDPE 461 + G+ GYL PE Sbjct: 187 LCGTPGYLAPE 197
>PHKG2_HUMAN (P15735) Phosphorylase b kinase gamma catalytic chain, testis/liver| isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase gamma subunit 2) (PSK-C3) Length = 406 Score = 62.4 bits (150), Expect = 7e-10 Identities = 47/150 (31%), Positives = 78/150 (52%), Gaps = 2/150 (1%) Frame = +3 Query: 18 KVAVKRGNQKSHQGLREF-RTEIELLSGLR-HRHLVSLIGYCDEQNEMILVYEYMEKGTL 191 +V +R + + + +RE R E +L + H H+++LI + + M LV++ M KG L Sbjct: 56 EVTAERLSPEQLEEVREATRRETHILRQVAGHPHIITLIDSYESSSFMFLVFDLMRKGEL 115 Query: 192 KSHLYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVS 371 +L ++ L K+ I + + H A +I+HRD+K NILLD+N+ ++S Sbjct: 116 FDYL--TEKVALSEKETRSIMRSLLEAVSFLH---ANNIVHRDLKPENILLDDNMQIRLS 170 Query: 372 DFGLSKTGPELDQTHVSTAVKGSFGYLDPE 461 DFG S L+ + G+ GYL PE Sbjct: 171 DFGFS---CHLEPGEKLRELCGTPGYLAPE 197
>YES_CANFA (Q28923) Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2)| (p61-Yes) (c-Yes) Length = 538 Score = 62.4 bits (150), Expect = 7e-10 Identities = 43/126 (34%), Positives = 68/126 (53%) Frame = +3 Query: 12 STKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTL 191 +TKVA+K + F E +++ LRH LV L E+ + +V E+M KG+L Sbjct: 294 TTKVAIKTLKLGTMMP-EAFLQEAQIMKKLRHDKLVPLYAVVSEE-PIYIVTEFMSKGSL 351 Query: 192 KSHLYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVS 371 L D L + V++ A G+ Y + IHRD+++ANIL+ ENL+ K++ Sbjct: 352 LDFLKEGDGKYLKLPQLVDMAAQIADGMAYIER---MNYIHRDLRAANILVGENLVCKIA 408 Query: 372 DFGLSK 389 DFGL++ Sbjct: 409 DFGLAR 414
>STK6_HUMAN (O14965) Serine/threonine-protein kinase 6 (EC 2.7.11.1)| (Serine/threonine kinase 15) (Aurora/IPL1-related kinase 1) (Aurora-related kinase 1) (hARK1) (Aurora-A) (Breast-tumor-amplified kinase) Length = 403 Score = 62.4 bits (150), Expect = 7e-10 Identities = 41/132 (31%), Positives = 63/132 (47%) Frame = +3 Query: 66 EFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYGSDMPPLGWKKRV 245 + R E+E+ S LRH +++ L GY + + L+ EY GT+ L + ++ Sbjct: 177 QLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYREL--QKLSKFDEQRTA 234 Query: 246 EICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSKTGPELDQTHVST 425 A L Y H +K +IHRD+K N+LL K++DFG S P + T Sbjct: 235 TYITELANALSYCH---SKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRR----T 287 Query: 426 AVKGSFGYLDPE 461 + G+ YL PE Sbjct: 288 TLCGTLDYLPPE 299
>ANPRB_RAT (P16067) Atrial natriuretic peptide receptor B precursor (ANP-B)| (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor) Length = 1047 Score = 62.4 bits (150), Expect = 7e-10 Identities = 43/160 (26%), Positives = 77/160 (48%), Gaps = 2/160 (1%) Frame = +3 Query: 21 VAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSH 200 VA+K N+K + R+ E++ + ++ HL IG C + + +V EY +G+L+ Sbjct: 548 VAIKHVNKKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQD- 606 Query: 201 LYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDFG 380 + +D L W R + +G+ + H S H +KS+N ++D + K++D+G Sbjct: 607 ILENDSINLDWMFRYSLINDLVKGMAFLHNSIISS--HGSLKSSNCVVDSRFVLKITDYG 664 Query: 381 LS--KTGPELDQTHVSTAVKGSFGYLDPEYYRRQS*PTVG 494 L+ ++ E D +H A K + PE PT G Sbjct: 665 LASFRSTAEPDDSHALYAKK---LWTAPELLSGNPLPTTG 701
>ANPRB_MOUSE (Q6VVW5) Atrial natriuretic peptide receptor B precursor (ANP-B)| (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor) Length = 1047 Score = 62.4 bits (150), Expect = 7e-10 Identities = 43/160 (26%), Positives = 77/160 (48%), Gaps = 2/160 (1%) Frame = +3 Query: 21 VAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSH 200 VA+K N+K + R+ E++ + ++ HL IG C + + +V EY +G+L+ Sbjct: 548 VAIKHVNKKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQD- 606 Query: 201 LYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDFG 380 + +D L W R + +G+ + H S H +KS+N ++D + K++D+G Sbjct: 607 ILENDSINLDWMFRYSLINDLVKGMAFLHNSIISS--HGSLKSSNCVVDSRFVLKITDYG 664 Query: 381 LS--KTGPELDQTHVSTAVKGSFGYLDPEYYRRQS*PTVG 494 L+ ++ E D +H A K + PE PT G Sbjct: 665 LASFRSTAEPDDSHALYAKK---LWTAPELLSGNPLPTTG 701
>ANPRB_HUMAN (P20594) Atrial natriuretic peptide receptor B precursor (ANP-B)| (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor) Length = 1047 Score = 62.4 bits (150), Expect = 7e-10 Identities = 43/160 (26%), Positives = 77/160 (48%), Gaps = 2/160 (1%) Frame = +3 Query: 21 VAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSH 200 VA+K N+K + R+ E++ + ++ HL IG C + + +V EY +G+L+ Sbjct: 548 VAIKHVNKKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQD- 606 Query: 201 LYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDFG 380 + +D L W R + +G+ + H S H +KS+N ++D + K++D+G Sbjct: 607 ILENDSINLDWMFRYSLINDLVKGMAFLHNSIISS--HGSLKSSNCVVDSRFVLKITDYG 664 Query: 381 LS--KTGPELDQTHVSTAVKGSFGYLDPEYYRRQS*PTVG 494 L+ ++ E D +H A K + PE PT G Sbjct: 665 LASFRSTAEPDDSHALYAKK---LWTAPELLSGNPLPTTG 701
>SRMS_MOUSE (Q62270) Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70)| Length = 496 Score = 62.4 bits (150), Expect = 7e-10 Identities = 35/110 (31%), Positives = 56/110 (50%) Frame = +3 Query: 60 LREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYGSDMPPLGWKK 239 L + EIE L LRH L+ L C + +V E M KG L+ +L S+ L Sbjct: 271 LADLTKEIEALKSLRHERLIRLHAICSLGEPVYIVTELMGKGNLQVYLGSSEGKALSLPH 330 Query: 240 RVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSK 389 + A G+ Y + ++HRD+ + N+L+ ++L KV+DFGL++ Sbjct: 331 LLGFACQVAEGMSYLE---ERRVVHRDLAARNVLVGDDLTCKVADFGLAR 377
>PTK7_CHICK (Q91048) Tyrosine-protein kinase-like 7 precursor (Kinase-like| protein) Length = 1051 Score = 62.4 bits (150), Expect = 7e-10 Identities = 42/130 (32%), Positives = 59/130 (45%), Gaps = 7/130 (5%) Frame = +3 Query: 21 VAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSH 200 V VK + Q +FR E E+ L H ++V L+G C E +V EY++ G LK Sbjct: 808 VLVKSLQTRDEQLQLDFRREAEMFGKLNHVNVVRLLGLCREAEPHYMVLEYVDLGDLKQF 867 Query: 201 LYGSDM-------PPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLM 359 L S PL K +V +C A G+ + G +HRD+ + N L+ Sbjct: 868 LRISKSKDESLKPQPLSTKHKVSLCTQVALGMEHLSNG---RFVHRDLAARNCLVSAQRQ 924 Query: 360 AKVSDFGLSK 389 KVS LSK Sbjct: 925 VKVSALSLSK 934
>IGF1R_XENLA (O73798) Insulin-like growth factor 1 receptor precursor (EC| 2.7.10.1) (xIGF-1R) (xIGFR) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain] Length = 1358 Score = 62.4 bits (150), Expect = 7e-10 Identities = 40/140 (28%), Positives = 68/140 (48%), Gaps = 9/140 (6%) Frame = +3 Query: 15 TKVAVKRGNQKSHQGLR-EFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTL 191 TKVA+K N+ + R EF E ++ H+V L+G + +++ E M +G L Sbjct: 1024 TKVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDL 1083 Query: 192 KSHLYG--------SDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLD 347 KS+L S P KK +++ A G+ Y + A +HRD+ + N ++ Sbjct: 1084 KSYLRSLRPDTESNSGQPTPSLKKMIQMAGEIADGMSYLN---ANKFVHRDLAARNCMVT 1140 Query: 348 ENLMAKVSDFGLSKTGPELD 407 E+ K+ DFG+++ E D Sbjct: 1141 EDFTVKIGDFGMTRDIYETD 1160
>LCK_AOTNA (Q5PXS1) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) Length = 508 Score = 62.4 bits (150), Expect = 7e-10 Identities = 43/127 (33%), Positives = 66/127 (51%) Frame = +3 Query: 9 DSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGT 188 D TKVAVK Q S F E L+ L+H+ LV L Q + ++ EYME G+ Sbjct: 265 DHTKVAVKSLKQGS-MSPDAFLAEANLMKQLQHQRLVRLYAVVT-QEPIYIITEYMENGS 322 Query: 189 LKSHLYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKV 368 L L L K +++ A G+ + ++ IHRD+++ANIL+ + L K+ Sbjct: 323 LVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEE---RNYIHRDLRAANILVSDTLSCKI 379 Query: 369 SDFGLSK 389 +DFGL++ Sbjct: 380 ADFGLAR 386
>YRK_CHICK (Q02977) Proto-oncogene tyrosine-protein kinase Yrk (EC 2.7.10.2)| (p60-Yrk) (Yes-related kinase) Length = 535 Score = 62.0 bits (149), Expect = 9e-10 Identities = 42/126 (33%), Positives = 68/126 (53%) Frame = +3 Query: 12 STKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTL 191 +TKVAVK + F E +++ LRH LV L E+ + +V E+M +G+L Sbjct: 291 TTKVAVKT-LKPGTMSPEAFLEEAQIMKRLRHDKLVQLYAVVSEE-PIYIVTEFMSQGSL 348 Query: 192 KSHLYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVS 371 L D L + V++ A G+ Y + IHRD+++ANIL+ +NL+ K++ Sbjct: 349 LDFLKDGDGRYLKLPQLVDMAAQIAAGMAYIER---MNYIHRDLRAANILVGDNLVCKIA 405 Query: 372 DFGLSK 389 DFGL++ Sbjct: 406 DFGLAR 411
>M3K2_ARATH (Q9FZ36) Mitogen-activated protein kinase kinase kinase 2 (EC| 2.7.11.25) (Arabidospsis NPK1-related protein kinase 2) Length = 651 Score = 62.0 bits (149), Expect = 9e-10 Identities = 41/142 (28%), Positives = 75/142 (52%), Gaps = 2/142 (1%) Frame = +3 Query: 42 QKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHL--YGSD 215 +K+ ++E E++LL L H ++V +G E + ++ E++ G++ S L +G+ Sbjct: 109 EKTQAHIQELEEEVKLLKNLSHPNIVRYLGTVREDETLNILLEFVPGGSISSLLEKFGAF 168 Query: 216 MPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSKTG 395 + ++ +G L Y H +I+HRD+K ANIL+D K++DFG SK Sbjct: 169 PESVVRTYTNQLLLG----LEYLHN---HAIMHRDIKGANILVDNQGCIKLADFGASKQV 221 Query: 396 PELDQTHVSTAVKGSFGYLDPE 461 EL + ++KG+ ++ PE Sbjct: 222 AELATISGAKSMKGTPYWMAPE 243
>ARAF_PIG (O19004) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (A-Raf-1) Length = 606 Score = 62.0 bits (149), Expect = 9e-10 Identities = 43/152 (28%), Positives = 74/152 (48%) Frame = +3 Query: 21 VAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSH 200 V V + Q + + + F+ E+++L RH +++ +G+ I+ ++ E +L H Sbjct: 335 VKVLKVAQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIIT-QWCEGSSLYHH 393 Query: 201 LYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDFG 380 L+ +D + +++ A+G+ Y H AK+IIHRD+KS NI L E L K+ DFG Sbjct: 394 LHVADTR-FDMVQLIDVARQTAQGMDYLH---AKNIIHRDLKSNNIFLHEGLTVKIGDFG 449 Query: 381 LSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQ 476 L+ GS ++ E R Q Sbjct: 450 LATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQ 481
>PKN2_CLOPE (Q8XJL8) Probable serine/threonine protein kinase CPE1738 (EC| 2.7.11.1) Length = 685 Score = 62.0 bits (149), Expect = 9e-10 Identities = 42/134 (31%), Positives = 70/134 (52%) Frame = +3 Query: 60 LREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYGSDMPPLGWKK 239 +R F+ E ++ L + ++V+++ + + +V EY+E TLK + + L ++ Sbjct: 52 VRRFKKEATAIANLSNPNVVNVLDVGTQDDINYIVMEYVEGKTLKDII--KEKGALPYEV 109 Query: 240 RVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSKTGPELDQTHV 419 + I I A+ L H IIHRDVK NIL+ E + KV+DFG++K+ H Sbjct: 110 AISIGIKVAKALECAHKS---GIIHRDVKPQNILVTEEGVVKVTDFGIAKSMDSSTIAH- 165 Query: 420 STAVKGSFGYLDPE 461 + +V GS Y PE Sbjct: 166 TNSVMGSAHYFSPE 179
>M3K13_HUMAN (O43283) Mitogen-activated protein kinase kinase kinase 13 (EC| 2.7.11.25) (Mixed lineage kinase) (MLK) (Leucine zipper-bearing kinase) Length = 966 Score = 62.0 bits (149), Expect = 9e-10 Identities = 45/154 (29%), Positives = 75/154 (48%), Gaps = 1/154 (0%) Frame = +3 Query: 18 KVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKS 197 +VA+K+ +++ T+I+ L L+H ++++ G C + ++ EY G L Sbjct: 191 EVAIKKVREQNE-------TDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYE 243 Query: 198 HLY-GSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSD 374 L G + P + V+ G A G++Y H IIHRD+KS N+L+ K+SD Sbjct: 244 VLRAGRKITP---RLLVDWSTGIASGMNYLHL---HKIIHRDLKSPNVLVTHTDAVKISD 297 Query: 375 FGLSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQ 476 FG SK EL + G+ ++ PE R + Sbjct: 298 FGTSK---ELSDKSTKMSFAGTVAWMAPEVIRNE 328
>ANPRB_BOVIN (P46197) Atrial natriuretic peptide receptor B precursor (ANP-B)| (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor) Length = 1047 Score = 62.0 bits (149), Expect = 9e-10 Identities = 43/160 (26%), Positives = 77/160 (48%), Gaps = 2/160 (1%) Frame = +3 Query: 21 VAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSH 200 VA+K N+K + R+ E++ + ++ HL IG C + + +V EY +G+L+ Sbjct: 548 VAIKHVNKKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQD- 606 Query: 201 LYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDFG 380 + +D L W R + +G+ + H S H +KS+N ++D + K++D+G Sbjct: 607 ILENDSINLDWMFRYSLINDLVKGMAFLHNSIIAS--HGSLKSSNCVVDSRFVLKITDYG 664 Query: 381 LS--KTGPELDQTHVSTAVKGSFGYLDPEYYRRQS*PTVG 494 L+ ++ E D +H A K + PE PT G Sbjct: 665 LASFRSTAEPDDSHALYAKK---LWTAPELLSGNPLPTTG 701
>INSR_RAT (P15127) Insulin receptor precursor (EC 2.7.10.1) (IR) [Contains:| Insulin receptor alpha subunit; Insulin receptor beta subunit] Length = 1383 Score = 62.0 bits (149), Expect = 9e-10 Identities = 41/140 (29%), Positives = 68/140 (48%), Gaps = 9/140 (6%) Frame = +3 Query: 15 TKVAVKRGNQKSHQGLR-EFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTL 191 T+VAVK N+ + R EF E ++ G H+V L+G + ++V E M G L Sbjct: 1053 TRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDL 1112 Query: 192 KSHL--------YGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLD 347 KSHL PP ++ +++ A G+ Y + AK +HRD+ + N ++ Sbjct: 1113 KSHLRSLRPDAENNPGRPPPTLQEMIQMTAEIADGMAYLN---AKKFVHRDLAARNCMVA 1169 Query: 348 ENLMAKVSDFGLSKTGPELD 407 + K+ DFG+++ E D Sbjct: 1170 HDFTVKIGDFGMTRDIYETD 1189
>FGFR2_XENLA (Q03364) Fibroblast growth factor receptor 2 precursor (EC| 2.7.10.1) (FGFR-2) Length = 813 Score = 62.0 bits (149), Expect = 9e-10 Identities = 40/150 (26%), Positives = 80/150 (53%), Gaps = 16/150 (10%) Frame = +3 Query: 6 QDSTKVAVKR-GNQKSHQGLREFRTEIELLSGL-RHRHLVSLIGYCDEQNEMILVYEYME 179 ++S VAVK + + + L + +E+E++ + +H+++++L+G C + + ++ EY Sbjct: 499 KESVTVAVKMLKDNATEKDLADLVSEMEMMKMIGKHKNIINLLGACTQGGTLYVIVEYAA 558 Query: 180 KGTLKSHL---------YGSDMP-----PLGWKKRVEICIGAARGLHYQHTGFAKSIIHR 317 KG L+ +L Y D+ + +K V ARG+ Y + + IHR Sbjct: 559 KGNLRQYLRARRPLEMEYSFDVTRVPDEQMTFKDLVSCTYQIARGMEYLAS---QKCIHR 615 Query: 318 DVKSANILLDENLMAKVSDFGLSKTGPELD 407 D+ + N+L+ EN + K++DFGL++ +D Sbjct: 616 DLAARNVLVTENNVMKIADFGLARDVNNID 645
>AAPK1_CAEEL (P45894) 5'-AMP-activated protein kinase catalytic subunit alpha-1| (EC 2.7.11.1) (AMP-activated kinase 1) Length = 589 Score = 62.0 bits (149), Expect = 9e-10 Identities = 52/156 (33%), Positives = 74/156 (47%), Gaps = 3/156 (1%) Frame = +3 Query: 3 LQDSTKVAVK---RGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEY 173 +Q VA+K RG K + + R EI+ L L H H+ L +++ LV E Sbjct: 44 IQTGYDVAIKILNRGRMKGLGTVNKTRNEIDNLQKLTHPHITRLFRVISTPSDIFLVMEL 103 Query: 174 MEKGTLKSHLYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDEN 353 + G L S++ P+ +R I G+ Y H I+HRD+K N+LLD N Sbjct: 104 VSGGELFSYITRKGALPIRESRRYFQQI--ISGVSYCHNHM---IVHRDLKPENLLLDAN 158 Query: 354 LMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPE 461 K++DFGLS + D +STA GS Y PE Sbjct: 159 KNIKIADFGLSNYMTDGDL--LSTAC-GSPNYAAPE 191
>FRK_HUMAN (P42685) Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear| tyrosine protein kinase RAK) Length = 505 Score = 62.0 bits (149), Expect = 9e-10 Identities = 36/127 (28%), Positives = 69/127 (54%) Frame = +3 Query: 9 DSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGT 188 ++T VAVK S +F E +++ LRH L+ L C ++ + ++ E M G+ Sbjct: 255 NTTPVAVKTLKPGSMDP-NDFLREAQIMKNLRHPKLIQLYAVCTLEDPIYIITELMRHGS 313 Query: 189 LKSHLYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKV 368 L+ +L + ++V++ A G+ Y + ++ IHRD+ + N+L+ E+ + KV Sbjct: 314 LQEYLQNDTGSKIHLTQQVDMAAQVASGMAYLES---RNYIHRDLAARNVLVGEHNIYKV 370 Query: 369 SDFGLSK 389 +DFGL++ Sbjct: 371 ADFGLAR 377
>ARAF_RAT (P14056) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) Length = 604 Score = 62.0 bits (149), Expect = 9e-10 Identities = 43/152 (28%), Positives = 74/152 (48%) Frame = +3 Query: 21 VAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSH 200 V V + Q + + + F+ E+++L RH +++ +G+ I+ ++ E +L H Sbjct: 333 VKVLKVAQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIIT-QWCEGSSLYHH 391 Query: 201 LYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDFG 380 L+ +D + +++ A+G+ Y H AK+IIHRD+KS NI L E L K+ DFG Sbjct: 392 LHVADTR-FDMVQLIDVARQTAQGMDYLH---AKNIIHRDLKSNNIFLHEGLTVKIGDFG 447 Query: 381 LSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQ 476 L+ GS ++ E R Q Sbjct: 448 LATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQ 479
>ARAF_MOUSE (P04627) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) Length = 604 Score = 62.0 bits (149), Expect = 9e-10 Identities = 43/152 (28%), Positives = 74/152 (48%) Frame = +3 Query: 21 VAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSH 200 V V + Q + + + F+ E+++L RH +++ +G+ I+ ++ E +L H Sbjct: 333 VKVLKVAQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIIT-QWCEGSSLYHH 391 Query: 201 LYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDFG 380 L+ +D + +++ A+G+ Y H AK+IIHRD+KS NI L E L K+ DFG Sbjct: 392 LHVADTR-FDMVQLIDVARQTAQGMDYLH---AKNIIHRDLKSNNIFLHEGLTVKIGDFG 447 Query: 381 LSKTGPELDQTHVSTAVKGSFGYLDPEYYRRQ 476 L+ GS ++ E R Q Sbjct: 448 LATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQ 479
>MELK_MOUSE (Q61846) Maternal embryonic leucine zipper kinase (EC 2.7.11.1)| (Protein kinase PK38) (mPK38) Length = 643 Score = 62.0 bits (149), Expect = 9e-10 Identities = 44/141 (31%), Positives = 67/141 (47%), Gaps = 1/141 (0%) Frame = +3 Query: 60 LREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYGSDMPPLGWKK 239 L +TEI+ L LRH+H+ L + +N++ +V EY G L ++ D L ++ Sbjct: 51 LPRVKTEIDALKSLRHQHICQLYHVLETKNKIFMVLEYCPGGELFDYIISQDR--LSEEE 108 Query: 240 RVEICIGAARGLHYQHT-GFAKSIIHRDVKSANILLDENLMAKVSDFGLSKTGPELDQTH 416 + + Y H+ G+A HRD+K N+L DEN K+ DFGL H Sbjct: 109 TRVVFRQILSAVAYVHSQGYA----HRDLKPENLLFDENHKLKLIDFGLCAKPKGNKDYH 164 Query: 417 VSTAVKGSFGYLDPEYYRRQS 479 + T GS Y PE + +S Sbjct: 165 LQTCC-GSLAYAAPELIQGKS 184
>ICL1_KLULA (Q6CWQ4) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) Length = 361 Score = 62.0 bits (149), Expect = 9e-10 Identities = 40/133 (30%), Positives = 64/133 (48%) Frame = +3 Query: 63 REFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYGSDMPPLGWKKR 242 ++FR E+E+ +H++L L G+ ++ + L+ EY+ G L L + PL Sbjct: 143 KQFRREVEIQGSFKHKNLTQLYGFFYDEKRVYLLMEYVYYGELYKFLKNNG--PLNETLA 200 Query: 243 VEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSKTGPELDQTHVS 422 A L Y H+ K+I+HRD+K NIL+ N K++DFG S + Sbjct: 201 SYFVYQMANALDYMHS---KNILHRDIKPENILIGFNNTIKLTDFGWSVYN---EDGQKR 254 Query: 423 TAVKGSFGYLDPE 461 + G+ YL PE Sbjct: 255 KTLCGTIDYLSPE 267
>SRK2_SPOLA (P42688) Tyrosine-protein kinase SRK2 (EC 2.7.10.2) (Fragment)| Length = 362 Score = 61.6 bits (148), Expect = 1e-09 Identities = 40/127 (31%), Positives = 67/127 (52%) Frame = +3 Query: 9 DSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGT 188 +ST VAVK + Q F E +++ LRH L+ L C + + ++ E M KG+ Sbjct: 116 NSTPVAVKTLKAGTMQPAA-FLAEAQIMKKLRHPKLIQLYAVCTQGEPVYIITELMSKGS 174 Query: 189 LKSHLYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKV 368 L +L G + L + +++ A G+ Y + IHRD+ + NIL+ +N + KV Sbjct: 175 LLDYLQG-EAGALKLPQLIDMAAQVAAGMAYLE---LHNYIHRDLAARNILVGDNNICKV 230 Query: 369 SDFGLSK 389 +DFGL++ Sbjct: 231 ADFGLAR 237
>LIMK1_CHICK (Q8QFP8) LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (chLIMK1)| Length = 662 Score = 61.6 bits (148), Expect = 1e-09 Identities = 35/109 (32%), Positives = 59/109 (54%) Frame = +3 Query: 63 REFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYGSDMPPLGWKKR 242 R F E++++ L H +++ IG ++ + + EY++ GTL+ + D W +R Sbjct: 386 RTFLKEVKVMRCLEHPNVLKFIGVLYKEKRLNFITEYIKGGTLRGLIKSMDSH-YPWSQR 444 Query: 243 VEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSK 389 V A G+ Y H+ +IIHRD+ S N L+ EN V+DFGL++ Sbjct: 445 VSFAKDIAAGMAYLHS---MNIIHRDLNSHNCLVRENKSVVVADFGLAR 490
>TIE2_MOUSE (Q02858) Angiopoietin-1 receptor precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (HYK) (STK1) (CD202b antigen) Length = 1122 Score = 61.6 bits (148), Expect = 1e-09 Identities = 44/138 (31%), Positives = 70/138 (50%), Gaps = 16/138 (11%) Frame = +3 Query: 24 AVKRGNQ-KSHQGLREFRTEIELLSGLRHR-HLVSLIGYCDEQNEMILVYEYMEKGTL-- 191 A+KR + S R+F E+E+L L H ++++L+G C+ + + L EY G L Sbjct: 851 AIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLD 910 Query: 192 ---KSHLYGSD---------MPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSAN 335 KS + +D L ++ + ARG+ Y K IHRD+ + N Sbjct: 911 FLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQ---KQFIHRDLAARN 967 Query: 336 ILLDENLMAKVSDFGLSK 389 IL+ EN +AK++DFGLS+ Sbjct: 968 ILVGENYIAKIADFGLSR 985
>TIE2_HUMAN (Q02763) Angiopoietin-1 receptor precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (CD202b antigen) Length = 1124 Score = 61.6 bits (148), Expect = 1e-09 Identities = 44/138 (31%), Positives = 70/138 (50%), Gaps = 16/138 (11%) Frame = +3 Query: 24 AVKRGNQ-KSHQGLREFRTEIELLSGLRHR-HLVSLIGYCDEQNEMILVYEYMEKGTL-- 191 A+KR + S R+F E+E+L L H ++++L+G C+ + + L EY G L Sbjct: 853 AIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLD 912 Query: 192 ---KSHLYGSD---------MPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSAN 335 KS + +D L ++ + ARG+ Y K IHRD+ + N Sbjct: 913 FLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQ---KQFIHRDLAARN 969 Query: 336 ILLDENLMAKVSDFGLSK 389 IL+ EN +AK++DFGLS+ Sbjct: 970 ILVGENYVAKIADFGLSR 987
>TIE2_BOVIN (Q06807) Angiopoietin-1 receptor precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor TIE-2) (CD202b antigen) Length = 1125 Score = 61.6 bits (148), Expect = 1e-09 Identities = 44/138 (31%), Positives = 70/138 (50%), Gaps = 16/138 (11%) Frame = +3 Query: 24 AVKRGNQ-KSHQGLREFRTEIELLSGLRHR-HLVSLIGYCDEQNEMILVYEYMEKGTL-- 191 A+KR + S R+F E+E+L L H ++++L+G C+ + + L EY G L Sbjct: 854 AIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLD 913 Query: 192 ---KSHLYGSD---------MPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSAN 335 KS + +D L ++ + ARG+ Y K IHRD+ + N Sbjct: 914 FLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQ---KQFIHRDLAARN 970 Query: 336 ILLDENLMAKVSDFGLSK 389 IL+ EN +AK++DFGLS+ Sbjct: 971 ILVGENYVAKIADFGLSR 988
>ANPRB_ANGJA (P55202) Atrial natriuretic peptide receptor B precursor (ANP-B)| (ANPRB) (GC-B) (Guanylate cyclase) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor) Length = 1050 Score = 61.6 bits (148), Expect = 1e-09 Identities = 37/140 (26%), Positives = 73/140 (52%), Gaps = 2/140 (1%) Frame = +3 Query: 21 VAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSH 200 VA+K N+K + R+ E++ + ++ HL IG C + + +V EY +G+L+ Sbjct: 552 VAIKHVNKKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDI 611 Query: 201 LYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDFG 380 L + L W R + +G+++ H + S H ++KS+N ++D + K++D+G Sbjct: 612 LENESI-NLDWMFRYSLINDIVKGMNFLHNSYIGS--HGNLKSSNCVVDSRFVLKITDYG 668 Query: 381 LS--KTGPELDQTHVSTAVK 434 L+ ++ E + +H A K Sbjct: 669 LASFRSSCENEDSHALYAKK 688
>PHKG2_RAT (P31325) Phosphorylase b kinase gamma catalytic chain, testis/liver| isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase gamma subunit 2) Length = 406 Score = 61.6 bits (148), Expect = 1e-09 Identities = 42/131 (32%), Positives = 69/131 (52%), Gaps = 1/131 (0%) Frame = +3 Query: 72 RTEIELLSGLR-HRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYGSDMPPLGWKKRVE 248 R E+ +L + H H+++LI + + M LV++ M KG L +L ++ L K+ Sbjct: 75 RREMHILRQVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYL--TEKVALSEKETRS 132 Query: 249 ICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSKTGPELDQTHVSTA 428 I +++ H +I+HRD+K NILLD+N+ ++SDFG S L+ Sbjct: 133 IMRSLLEAVNFLHVN---NIVHRDLKPENILLDDNMQIRLSDFGFS---CHLEPGEKLRE 186 Query: 429 VKGSFGYLDPE 461 + G+ GYL PE Sbjct: 187 LCGTPGYLAPE 197
>FYN_MOUSE (P39688) Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2)| (p59-Fyn) Length = 533 Score = 61.2 bits (147), Expect = 2e-09 Identities = 41/126 (32%), Positives = 65/126 (51%) Frame = +3 Query: 12 STKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTL 191 +TKVA+K + F E +++ L+H LV L E+ + +V EYM KG+L Sbjct: 289 NTKVAIKT-LKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEE-PIYIVTEYMSKGSL 346 Query: 192 KSHLYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVS 371 L + L V++ A G+ Y + IHRD++SANIL+ L+ K++ Sbjct: 347 LDFLKDGEGRALKLPNLVDMAAQVAAGMAYIER---MNYIHRDLRSANILVGNGLICKIA 403 Query: 372 DFGLSK 389 DFGL++ Sbjct: 404 DFGLAR 409
>M3K1_ARATH (O22040) Mitogen-activated protein kinase kinase kinase 1 (EC| 2.7.11.25) (Arabidospsis NPK1-related protein kinase 1) Length = 666 Score = 61.2 bits (147), Expect = 2e-09 Identities = 41/140 (29%), Positives = 70/140 (50%) Frame = +3 Query: 42 QKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYGSDMP 221 +K+ ++E E++LL L H ++V +G E + + ++ E++ G++ S L Sbjct: 110 EKTQAHIQELEEEVKLLKNLSHPNIVRYLGTVREDDTLNILLEFVPGGSISSLL--EKFG 167 Query: 222 PLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSKTGPE 401 P GL Y H +I+HRD+K ANIL+D K++DFG SK E Sbjct: 168 PFPESVVRTYTRQLLLGLEYLHN---HAIMHRDIKGANILVDNKGCIKLADFGASKQVAE 224 Query: 402 LDQTHVSTAVKGSFGYLDPE 461 L + ++KG+ ++ PE Sbjct: 225 LATMTGAKSMKGTPYWMAPE 244
>ANPRA_HUMAN (P16066) Atrial natriuretic peptide receptor A precursor (ANP-A)| (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor) Length = 1061 Score = 61.2 bits (147), Expect = 2e-09 Identities = 45/159 (28%), Positives = 79/159 (49%), Gaps = 1/159 (0%) Frame = +3 Query: 21 VAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSH 200 VAVKR N+K + R+ E++ + +++ HL +G C + + ++ EY +G+L+ Sbjct: 564 VAVKRVNRKRIELTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQDI 623 Query: 201 LYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDFG 380 L + L W R + +G+ + H G S H ++KS+N ++D + K++D+G Sbjct: 624 LENESI-TLDWMFRYSLTNDIVKGMLFLHNGAICS--HGNLKSSNCVVDGRFVLKITDYG 680 Query: 381 L-SKTGPELDQTHVSTAVKGSFGYLDPEYYRRQS*PTVG 494 L S + +Q H A K + PE R S P G Sbjct: 681 LESFRDLDPEQGHTVYAKK---LWTAPELLRMASPPVRG 716
>FYN_HUMAN (P06241) Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2)| (p59-Fyn) (Protooncogene Syn) (SLK) Length = 536 Score = 61.2 bits (147), Expect = 2e-09 Identities = 41/126 (32%), Positives = 65/126 (51%) Frame = +3 Query: 12 STKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTL 191 +TKVA+K + F E +++ L+H LV L E+ + +V EYM KG+L Sbjct: 292 NTKVAIKT-LKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEE-PIYIVTEYMNKGSL 349 Query: 192 KSHLYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVS 371 L + L V++ A G+ Y + IHRD++SANIL+ L+ K++ Sbjct: 350 LDFLKDGEGRALKLPNLVDMAAQVAAGMAYIER---MNYIHRDLRSANILVGNGLICKIA 406 Query: 372 DFGLSK 389 DFGL++ Sbjct: 407 DFGLAR 412
>ABL_DROME (P00522) Tyrosine-protein kinase Abl (EC 2.7.10.2) (Abelson| protein) (D-ash) Length = 1620 Score = 61.2 bits (147), Expect = 2e-09 Identities = 36/123 (29%), Positives = 64/123 (52%) Frame = +3 Query: 21 VAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSH 200 VAVK + + L++F E ++ ++H +LV LIG C + ++ E+M G L Sbjct: 397 VAVKTLKEDT-MALKDFLEEAAIMKEMKHPNLVQLIGVCTREPPFYIITEFMSHGNLLDF 455 Query: 201 LYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDFG 380 L + L + + A G+ Y +++ IHRD+ + N L+ +N + KV+DFG Sbjct: 456 LRSAGRETLDAVALLYMATQIASGMSYLE---SRNYIHRDLAARNCLVGDNKLVKVADFG 512 Query: 381 LSK 389 L++ Sbjct: 513 LAR 515
>PKNB_MYCTU (P0A5S4) Probable serine/threonine-protein kinase pknB (EC| 2.7.11.1) Length = 626 Score = 61.2 bits (147), Expect = 2e-09 Identities = 49/162 (30%), Positives = 79/162 (48%), Gaps = 14/162 (8%) Frame = +3 Query: 69 FRTEIELLSGLRHRHLVSLIGYCDEQNEM----ILVYEYMEKGTLKSHLYGSDMPPLGWK 236 FR E + + L H +V++ + + +V EY++ TL+ ++ P+ K Sbjct: 56 FRREAQNAAALNHPAIVAVYDTGEAETPAGPLPYIVMEYVDGVTLRDIVHTEG--PMTPK 113 Query: 237 KRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSK----TGPEL 404 + +E+ A + L++ H IIHRDVK ANI++ KV DFG+++ +G + Sbjct: 114 RAIEVIADACQALNFSHQN---GIIHRDVKPANIMISATNAVKVMDFGIARAIADSGNSV 170 Query: 405 DQTHVSTAVKGSFGYLDPEYYR------RQS*PTVGCVLIRV 512 QT AV G+ YL PE R R ++GCVL V Sbjct: 171 TQT---AAVIGTAQYLSPEQARGDSVDARSDVYSLGCVLYEV 209
>PKNB_MYCBO (P0A5S5) Probable serine/threonine-protein kinase pknB (EC| 2.7.11.1) Length = 626 Score = 61.2 bits (147), Expect = 2e-09 Identities = 49/162 (30%), Positives = 79/162 (48%), Gaps = 14/162 (8%) Frame = +3 Query: 69 FRTEIELLSGLRHRHLVSLIGYCDEQNEM----ILVYEYMEKGTLKSHLYGSDMPPLGWK 236 FR E + + L H +V++ + + +V EY++ TL+ ++ P+ K Sbjct: 56 FRREAQNAAALNHPAIVAVYDTGEAETPAGPLPYIVMEYVDGVTLRDIVHTEG--PMTPK 113 Query: 237 KRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSK----TGPEL 404 + +E+ A + L++ H IIHRDVK ANI++ KV DFG+++ +G + Sbjct: 114 RAIEVIADACQALNFSHQN---GIIHRDVKPANIMISATNAVKVMDFGIARAIADSGNSV 170 Query: 405 DQTHVSTAVKGSFGYLDPEYYR------RQS*PTVGCVLIRV 512 QT AV G+ YL PE R R ++GCVL V Sbjct: 171 TQT---AAVIGTAQYLSPEQARGDSVDARSDVYSLGCVLYEV 209
>BYR2_SCHPO (P28829) Protein kinase byr2 (EC 2.7.11.25) (Protein kinase ste8)| (MAPK kinase kinase) (MAPKKK) Length = 659 Score = 61.2 bits (147), Expect = 2e-09 Identities = 47/139 (33%), Positives = 73/139 (52%), Gaps = 7/139 (5%) Frame = +3 Query: 78 EIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHL--YGSDMPPLGWKKRVEI 251 EI LL L H H+V +G + + + EY+ G++ L YGS L K ++ Sbjct: 447 EIALLQELSHEHIVQYLGSNLNSDHLNIFLEYVPGGSVAGLLTMYGSFEETLV-KNFIKQ 505 Query: 252 CIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSKTGPELDQTHVST-- 425 + +GL Y H+ + I+HRD+K ANIL+D K+SDFG+SK EL+ T T Sbjct: 506 TL---KGLEYLHS---RGIVHRDIKGANILVDNKGKIKISDFGISKK-LELNSTSTKTGG 558 Query: 426 ---AVKGSFGYLDPEYYRR 473 + +GS ++ PE ++ Sbjct: 559 ARPSFQGSSFWMAPEVVKQ 577
>LIMK1_HUMAN (P53667) LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1)| Length = 647 Score = 61.2 bits (147), Expect = 2e-09 Identities = 39/119 (32%), Positives = 61/119 (51%), Gaps = 6/119 (5%) Frame = +3 Query: 63 REFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYGSDMPPLGWKKR 242 R F E++++ L H +++ IG + + + EY++ GTL+ + D W +R Sbjct: 379 RTFLKEVKVMRCLEHPNVLKFIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQ-YPWSQR 437 Query: 243 VEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLS------KTGPE 401 V A G+ Y H+ +IIHRD+ S N L+ EN V+DFGL+ KT PE Sbjct: 438 VSFAKDIASGMAYLHS---MNIIHRDLNSHNCLVRENKNVVVADFGLARLMVDEKTQPE 493
>KIN31_CAEEL (P34265) Probable tyrosine-protein kinase kin-31 (EC 2.7.10.2)| Length = 437 Score = 61.2 bits (147), Expect = 2e-09 Identities = 45/138 (32%), Positives = 71/138 (51%), Gaps = 2/138 (1%) Frame = +3 Query: 18 KVAVKRGNQKS--HQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTL 191 KVAVK+ +++F E + L H ++V +G Q + LV E G L Sbjct: 159 KVAVKQVKTDGIGKDQIKDFLMEARTMRNLGHPNIVRFLGIAVLQEPLFLVMELATGGAL 218 Query: 192 KSHLYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVS 371 S+L +++ P+ KR E+ + AA GL Y H K ++HRD+ + N L + + K+S Sbjct: 219 DSYLKHNELLPID--KRHEMLLQAAWGLEYIH---GKPMLHRDIAARNCLYGDGKV-KIS 272 Query: 372 DFGLSKTGPELDQTHVST 425 DFGL++ G + Q H T Sbjct: 273 DFGLTRRG-TIYQLHPET 289
>BMX_HUMAN (P51813) Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2)| (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38) Length = 675 Score = 61.2 bits (147), Expect = 2e-09 Identities = 38/122 (31%), Positives = 64/122 (52%), Gaps = 2/122 (1%) Frame = +3 Query: 66 EFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHL--YGSDMPPLGWKK 239 EF E + + L H LV G C ++ + +V EY+ G L ++L +G + P + Sbjct: 456 EFFQEAQTMMKLSHPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSHGKGLEP---SQ 512 Query: 240 RVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSKTGPELDQTHV 419 +E+C G+ + + IHRD+ + N L+D +L KVSDFG+++ LD +V Sbjct: 513 LLEMCYDVCEGMAFLES---HQFIHRDLAARNCLVDRDLCVKVSDFGMTRY--VLDDQYV 567 Query: 420 ST 425 S+ Sbjct: 568 SS 569
>EPA4A_BRARE (O13148) Ephrin type-A receptor 4a (EC 2.7.10.1) (Tyrosine-protein| kinase receptor ZEK2) (EPH-like kinase 2) (Fragment) Length = 292 Score = 60.8 bits (146), Expect = 2e-09 Identities = 39/128 (30%), Positives = 69/128 (53%), Gaps = 1/128 (0%) Frame = +3 Query: 63 REFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYGSDMPPLGWKKR 242 R+F +E ++ H +++ L G + ++++ EYME G+L + L +D + Sbjct: 39 RDFLSEASIMGQFDHPNIIRLEGVVTKCKPVMIITEYMENGSLDAFLRKND-GRFTVIQL 97 Query: 243 VEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSKTGPE-LDQTHV 419 V I G A G+ Y S +HRD+ + NIL++ NL+ KVSDFG+S+ E D + Sbjct: 98 VGILRGIASGMKYLSD---MSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEEDPDAAYT 154 Query: 420 STAVKGSF 443 + + G++ Sbjct: 155 TREITGTY 162
>EPHB5_CHICK (Q07497) Ephrin type-B receptor 5 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase CEK9) Length = 1002 Score = 60.8 bits (146), Expect = 2e-09 Identities = 36/109 (33%), Positives = 60/109 (55%) Frame = +3 Query: 63 REFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYGSDMPPLGWKKR 242 REF +E ++ H +++ L G + +++V E+ME G+L S L + + Sbjct: 681 REFLSEASIMGQFEHPNVIHLEGVVTKSRPVMIVTEFMENGSLDSFLRQKE-GQFSVLQL 739 Query: 243 VEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSK 389 V + G A G+ Y + +HRD+ + NIL++ NL+ KVSDFGLS+ Sbjct: 740 VGMLRGIAAGMRYLSD---MNYVHRDLAARNILVNSNLVCKVSDFGLSR 785
>MKH1_SCHPO (Q10407) MAP kinase kinase kinase mkh1 (EC 2.7.11.25)| Length = 1116 Score = 60.8 bits (146), Expect = 2e-09 Identities = 42/155 (27%), Positives = 80/155 (51%), Gaps = 10/155 (6%) Frame = +3 Query: 78 EIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHL--YGSDMPPLGWKKRVEI 251 EI +++ L H ++V +G+ + ++ + EY+ G++ L YG P + + Sbjct: 880 EISMIADLDHLNIVQYLGFEKTETDISIFLEYVSGGSIGRCLRNYG----PFEEQLVRFV 935 Query: 252 CIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSKTGPELDQTHVSTAV 431 GL Y H+ K IIHRD+K+ N+L+D + + K+SDFG+SK + + ++ Sbjct: 936 SRQVLYGLSYLHS---KGIIHRDLKADNLLIDFDGVCKISDFGISKHSDNVYDNDANLSM 992 Query: 432 KGSFGYLDPE--------YYRRQS*PTVGCVLIRV 512 +GS ++ PE Y + ++GCV++ + Sbjct: 993 QGSIFWMAPEVIHNDHQGYSAKVDVWSLGCVVLEM 1027
>LIMK1_RAT (P53669) LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1)| Length = 647 Score = 60.8 bits (146), Expect = 2e-09 Identities = 35/109 (32%), Positives = 58/109 (53%) Frame = +3 Query: 63 REFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYGSDMPPLGWKKR 242 R F E++++ L H +++ IG + + + EY++ GTL+ + D W +R Sbjct: 379 RTFLKEVKVMRCLEHPNVLKFIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQ-YPWSQR 437 Query: 243 VEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSK 389 V A G+ Y H+ +IIHRD+ S N L+ EN V+DFGL++ Sbjct: 438 VSFAKDIASGMAYLHS---MNIIHRDLNSHNCLVRENRNVVVADFGLAR 483
>LIMK1_MOUSE (P53668) LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (KIZ-1)| Length = 647 Score = 60.8 bits (146), Expect = 2e-09 Identities = 35/109 (32%), Positives = 58/109 (53%) Frame = +3 Query: 63 REFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYGSDMPPLGWKKR 242 R F E++++ L H +++ IG + + + EY++ GTL+ + D W +R Sbjct: 379 RTFLKEVKVMRCLEHPNVLKFIGVLYKDKRLNFITEYIKGGTLRGIIKNMDSQ-YPWSQR 437 Query: 243 VEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSK 389 V A G+ Y H+ +IIHRD+ S N L+ EN V+DFGL++ Sbjct: 438 VSFAKDIASGMAYLHS---MNIIHRDLNSHNCLVRENRNVVVADFGLAR 483
>LCK_SAISC (Q95KR7) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) Length = 508 Score = 60.8 bits (146), Expect = 2e-09 Identities = 41/127 (32%), Positives = 66/127 (51%) Frame = +3 Query: 9 DSTKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGT 188 + TKVAVK Q S F E L+ L+H+ LV L E+ + ++ EYME G+ Sbjct: 265 EHTKVAVKSLKQGS-MSPDAFLAEANLMKQLQHKRLVRLYAVVTEE-PIYIITEYMENGS 322 Query: 189 LKSHLYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKV 368 L L L K +++ G+ + ++ IHRD+++ANIL+ + L K+ Sbjct: 323 LVDFLKTPSGIKLTINKLLDMAAQIVEGMAFLEE---RNYIHRDLRAANILVSDTLSCKI 379 Query: 369 SDFGLSK 389 +DFGL++ Sbjct: 380 ADFGLAR 386
>AURKC_HUMAN (Q9UQB9) Serine/threonine-protein kinase 13 (EC 2.7.11.1)| (Aurora/Ipl1/Eg2 protein 2) (Aurora/Ipl1-related kinase 3) (Aurora-C) Length = 309 Score = 60.8 bits (146), Expect = 2e-09 Identities = 45/142 (31%), Positives = 69/142 (48%), Gaps = 1/142 (0%) Frame = +3 Query: 39 NQKSHQGLR-EFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYGSD 215 +Q +GL + R EIE+ + L+H +++ L Y + + L+ EY +G L L S+ Sbjct: 77 SQIEKEGLEHQLRREIEIQAHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSE 136 Query: 216 MPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSKTG 395 L ++ I A L Y H K +IHRD+K N+LL K++DFG S Sbjct: 137 K--LDEQRTATIIEELADALTYCHD---KKVIHRDIKPENLLLGFRGEVKIADFGWSVHT 191 Query: 396 PELDQTHVSTAVKGSFGYLDPE 461 P L + + G+ YL PE Sbjct: 192 PSLRR----KTMCGTLDYLPPE 209
>TSSK4_MOUSE (Q9D411) Testis-specific serine/threonine-protein kinase 4 (EC| 2.7.11.1) (TSSK-4) (Testis-specific kinase 4) (TSK-4) Length = 328 Score = 60.8 bits (146), Expect = 2e-09 Identities = 49/165 (29%), Positives = 80/165 (48%), Gaps = 18/165 (10%) Frame = +3 Query: 21 VAVKRGNQK--SHQGLREFRT-EIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTL 191 VAVK ++K S L +F EI+++ LRH++L++ + + + ++ E + G + Sbjct: 51 VAVKIISKKKASEDYLNKFLPREIQVMKVLRHKYLINFYQAIETTSRVYIILELAQGGDV 110 Query: 192 KSHL--YGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAK 365 + YG+ L K ++ +G A Y H+ K I+HRD+K N+LLD+ K Sbjct: 111 LEWIQRYGACAETLAGKWFSQMALGIA----YLHS---KGIVHRDLKLENLLLDKRENVK 163 Query: 366 VSDFGLSKTGPELDQTHVSTAVK-------------GSFGYLDPE 461 +SDFG +K P H S + + GSF Y PE Sbjct: 164 ISDFGFAKMVPSSQPVHSSPSYRQMNSLSHLSQTYCGSFAYACPE 208
>M3K12_HUMAN (Q12852) Mitogen-activated protein kinase kinase kinase 12 (EC| 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK) Length = 859 Score = 60.5 bits (145), Expect = 3e-09 Identities = 42/148 (28%), Positives = 76/148 (51%), Gaps = 1/148 (0%) Frame = +3 Query: 36 GNQKSHQGLREFR-TEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYGS 212 G + + + +R+ + T+I+ L L+H ++++ G C + ++ E+ +G L L Sbjct: 146 GEEVAVKKVRDLKETDIKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAG 205 Query: 213 DMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSKT 392 P+ V+ +G A G++Y H IIHRD+KS N+L+ + + K+SDFG SK Sbjct: 206 R--PVTPSLLVDWSMGIAGGMNYLHL---HKIIHRDLKSPNMLITYDDVVKISDFGTSK- 259 Query: 393 GPELDQTHVSTAVKGSFGYLDPEYYRRQ 476 EL + G+ ++ PE R + Sbjct: 260 --ELSDKSTKMSFAGTVAWMAPEVIRNE 285
>FGFR4_MOUSE (Q03142) Fibroblast growth factor receptor 4 precursor (EC| 2.7.10.1) (FGFR-4) (Protein-tyrosine kinase receptor MPK-11) Length = 799 Score = 60.5 bits (145), Expect = 3e-09 Identities = 38/149 (25%), Positives = 73/149 (48%), Gaps = 15/149 (10%) Frame = +3 Query: 6 QDSTKVAVKRGNQKSHQGLREFRTEIELLSGL-RHRHLVSLIGYCDEQNEMILVYEYMEK 182 Q ST + S + L + +E+E++ + RH+++++L+G C ++ + ++ E K Sbjct: 493 QTSTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAK 552 Query: 183 GTLKSHLYGSDMP--------------PLGWKKRVEICIGAARGLHYQHTGFAKSIIHRD 320 G L+ L P PL + V ARG+ Y + + IHRD Sbjct: 553 GNLREFLRARRPPGPDLSPDGPRSSEGPLSFPALVSCAYQVARGMQYLES---RKCIHRD 609 Query: 321 VKSANILLDENLMAKVSDFGLSKTGPELD 407 + + N+L+ E+ + K++DFGL++ +D Sbjct: 610 LAARNVLVTEDDVMKIADFGLARGVHHID 638
>CEK2_CHICK (P18460) Tyrosine kinase receptor CEK2 precursor (EC 2.7.10.1)| Length = 806 Score = 60.5 bits (145), Expect = 3e-09 Identities = 41/163 (25%), Positives = 82/163 (50%), Gaps = 16/163 (9%) Frame = +3 Query: 21 VAVKR-GNQKSHQGLREFRTEIELLSGL-RHRHLVSLIGYCDEQNEMILVYEYMEKGTLK 194 VAVK + + + L + +E+E++ + +H+++++L+G C + + ++ EY KG L+ Sbjct: 499 VAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVLVEYASKGNLR 558 Query: 195 SHLYGSDMP--------------PLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSA 332 +L P L +K V ARG+ Y + + IHRD+ + Sbjct: 559 EYLRARRPPGMDYSFDTCKLPEEQLTFKDLVSCAYQVARGMEYLAS---QKCIHRDLAAR 615 Query: 333 NILLDENLMAKVSDFGLSKTGPELDQTHVSTAVKGSFGYLDPE 461 N+L+ E+ + K++DFGL++ +D +T + ++ PE Sbjct: 616 NVLVTEDNVMKIADFGLARDVHNIDYYKKTTNGRLPVKWMAPE 658
>TRK1_LYMST (O76997) Putative neurotrophin receptor LTRK 1 precursor (EC| 2.7.10.1) Length = 794 Score = 60.5 bits (145), Expect = 3e-09 Identities = 39/151 (25%), Positives = 71/151 (47%), Gaps = 18/151 (11%) Frame = +3 Query: 63 REFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHL------------- 203 R+F E E+L+ + H ++V+ G C E ++ ++++E+ME G L +L Sbjct: 550 RDFEREAEMLATIEHANIVTFYGVCTESDQWMMIFEFMENGDLNKYLRMHGPDAAFLKDR 609 Query: 204 --YGSDMPPLGWKKRVEICIGAARGLHY---QHTGFAKSIIHRDVKSANILLDENLMAKV 368 SD L ++ ++I + A + Y QH +HRD+ + N L+ +L+ K+ Sbjct: 610 DSMDSDEGQLTREQLMKIVLQIASAMEYLALQH------FVHRDLATRNCLVGCDLVVKL 663 Query: 369 SDFGLSKTGPELDQTHVSTAVKGSFGYLDPE 461 DFG+S+ D V ++ PE Sbjct: 664 GDFGMSRDVYTTDYYRVEGTAMLPVRWMPPE 694
>EPHA2_MOUSE (Q03145) Ephrin type-A receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2) Length = 977 Score = 60.5 bits (145), Expect = 3e-09 Identities = 35/108 (32%), Positives = 57/108 (52%) Frame = +3 Query: 66 EFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYGSDMPPLGWKKRV 245 +F +E ++ H +++ L G + M+++ EYME G L L D + V Sbjct: 660 DFLSEASIMGQFSHHNIIPLEGVVSKYKPMMIITEYMENGALDKFLREKD-GEFSVLQLV 718 Query: 246 EICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSK 389 + G A G+ Y + +HRD+ + NIL++ NL+ KVSDFGLS+ Sbjct: 719 GMLRGIASGMKYLAN---MNYVHRDLAARNILVNSNLVCKVSDFGLSR 763
>RET_MOUSE (P35546) Proto-oncogene tyrosine-protein kinase receptor ret| precursor (EC 2.7.10.1) (C-ret) Length = 1115 Score = 60.5 bits (145), Expect = 3e-09 Identities = 44/154 (28%), Positives = 68/154 (44%), Gaps = 23/154 (14%) Frame = +3 Query: 15 TKVAVKRGNQKSHQG-LREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTL 191 T VAVK + + Q LR+ +E LL + H H++ L G C + ++L+ EY + G+L Sbjct: 754 TTVAVKMLKENASQSELRDLLSEFNLLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSL 813 Query: 192 KSHLYGS----------------------DMPPLGWKKRVEICIGAARGLHYQHTGFAKS 305 + L S D L + +RG+ Y Sbjct: 814 RGFLRDSRKIGPAYVSGGGSRNSSSLDHPDERVLTMGDLISFAWQISRGMQYLAE---MK 870 Query: 306 IIHRDVKSANILLDENLMAKVSDFGLSKTGPELD 407 ++HRD+ + NIL+ E K+SDFGLS+ E D Sbjct: 871 LVHRDLAARNILVAEGRKMKISDFGLSRDVYEED 904
>LCK_HUMAN (P06239) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell-specific protein-tyrosine kinase) Length = 508 Score = 60.5 bits (145), Expect = 3e-09 Identities = 42/125 (33%), Positives = 65/125 (52%) Frame = +3 Query: 15 TKVAVKRGNQKSHQGLREFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLK 194 TKVAVK Q S F E L+ L+H+ LV L Q + ++ EYME G+L Sbjct: 267 TKVAVKSLKQGS-MSPDAFLAEANLMKQLQHQRLVRLYAVVT-QEPIYIITEYMENGSLV 324 Query: 195 SHLYGSDMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSD 374 L L K +++ A G+ + ++ IHRD+++ANIL+ + L K++D Sbjct: 325 DFLKTPSGIKLTINKLLDMAAQIAEGMAFIEE---RNYIHRDLRAANILVSDTLSCKIAD 381 Query: 375 FGLSK 389 FGL++ Sbjct: 382 FGLAR 386
>LIMK1_XENLA (O42565) LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (xLIMK1)| Length = 615 Score = 60.5 bits (145), Expect = 3e-09 Identities = 37/113 (32%), Positives = 59/113 (52%) Frame = +3 Query: 63 REFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYGSDMPPLGWKKR 242 R F E++++ L H H++ IG + + + EY+ GTL+ + D W +R Sbjct: 354 RTFLKEVKVMRCLEHPHVLKFIGVLYKDKRLNFITEYIPGGTLRRVIKSMDTH-CPWNQR 412 Query: 243 VEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSKTGPE 401 V A G+ Y H+ +IIHRD+ S N L+ E+ V++FGLS+ PE Sbjct: 413 VSFARDIAAGMTYLHS---MNIIHRDLNSHNCLVREDGGLVVANFGLSRLIPE 462
>AURKC_MOUSE (O88445) Serine/threonine-protein kinase 13 (EC 2.7.11.1)| (Aurora/Ipl1/Eg2 protein 1) (Aurora-C) Length = 282 Score = 60.5 bits (145), Expect = 3e-09 Identities = 42/132 (31%), Positives = 63/132 (47%) Frame = +3 Query: 66 EFRTEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYGSDMPPLGWKKRV 245 + R E+E+ + L+HR+++ L Y + + L+ EY G L L L ++ Sbjct: 60 QLRREVEIQAHLQHRNILRLYNYFYDDTRIYLILEYAPGGELYKELQRHQK--LDQQRTA 117 Query: 246 EICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSKTGPELDQTHVST 425 I + L Y H K +IHRD+K N+LL N K+SDFG S P L + Sbjct: 118 TIIQELSDALTYCHE---KKVIHRDIKPENLLLGLNGEVKISDFGWSVHTPSLRR----K 170 Query: 426 AVKGSFGYLDPE 461 + G+ YL PE Sbjct: 171 TMCGTLDYLPPE 182
>M3K12_RAT (Q63796) Mitogen-activated protein kinase kinase kinase 12 (EC| 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK) Length = 888 Score = 60.5 bits (145), Expect = 3e-09 Identities = 42/148 (28%), Positives = 76/148 (51%), Gaps = 1/148 (0%) Frame = +3 Query: 36 GNQKSHQGLREFR-TEIELLSGLRHRHLVSLIGYCDEQNEMILVYEYMEKGTLKSHLYGS 212 G + + + +R+ + T+I+ L L+H ++++ G C + ++ E+ +G L L Sbjct: 179 GEEVAVKKVRDLKETDIKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAG 238 Query: 213 DMPPLGWKKRVEICIGAARGLHYQHTGFAKSIIHRDVKSANILLDENLMAKVSDFGLSKT 392 P+ V+ +G A G++Y H IIHRD+KS N+L+ + + K+SDFG SK Sbjct: 239 R--PVTPSLLVDWSMGIAGGMNYLHL---HKIIHRDLKSPNMLITYDDVVKISDFGTSK- 292 Query: 393 GPELDQTHVSTAVKGSFGYLDPEYYRRQ 476 EL + G+ ++ PE R + Sbjct: 293 --ELSDKSTKMSFAGTVAWMAPEVIRNE 318 Database: uniprot_sprot.fasta Posted date: May 25, 2006 5:36 PM Number of letters in database: 80,573,946 Number of sequences in database: 219,361 Lambda K H 0.318 0.135 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 73,354,830 Number of Sequences: 219361 Number of extensions: 1529048 Number of successful extensions: 6755 Number of sequences better than 10.0: 500 Number of HSP's better than 10.0 without gapping: 5855 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 6135 length of database: 80,573,946 effective HSP length: 104 effective length of database: 57,760,402 effective search space used: 3812186532 frameshift window, decay const: 50, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)
