>WIPI3_XENTR (Q640T2) WD-repeat domain phosphoinositide-interacting protein 3|
           (WIPI-3) (WD-repeat protein 45-like) (WDR45-like
           protein)
          Length = 344

 Score = 69.3 bits (168), Expect = 2e-12
 Identities = 30/49 (61%), Positives = 37/49 (75%)
 Frame = +2

Query: 143 EMLFRCNILALVGGGDAPHYPPNKVMIWDDHQSRCIGELSFKSPVRGVR 289
           EMLFRCN LALVGGG  P YPPNKVMIWDD + + + E+ F + V+ V+
Sbjct: 58  EMLFRCNYLALVGGGKKPKYPPNKVMIWDDLKKKTVIEIEFSTEVKAVK 106

>WIPI3_XENLA (Q68F45) WD-repeat domain phosphoinositide-interacting protein 3|
           (WIPI-3) (WD-repeat protein 45-like) (WDR45-like
           protein)
          Length = 344

 Score = 69.3 bits (168), Expect = 2e-12
 Identities = 30/49 (61%), Positives = 37/49 (75%)
 Frame = +2

Query: 143 EMLFRCNILALVGGGDAPHYPPNKVMIWDDHQSRCIGELSFKSPVRGVR 289
           EMLFRCN LALVGGG  P YPPNKVMIWDD + + + E+ F + V+ V+
Sbjct: 58  EMLFRCNYLALVGGGKKPKYPPNKVMIWDDLKKKTVIEIEFSTEVKAVK 106

>WIPI3_PONPY (Q5R7W0) WD-repeat domain phosphoinositide-interacting protein 3|
           (WIPI-3) (WD-repeat protein 45-like) (WDR45-like
           protein)
          Length = 344

 Score = 69.3 bits (168), Expect = 2e-12
 Identities = 30/49 (61%), Positives = 37/49 (75%)
 Frame = +2

Query: 143 EMLFRCNILALVGGGDAPHYPPNKVMIWDDHQSRCIGELSFKSPVRGVR 289
           EMLFRCN LALVGGG  P YPPNKVMIWDD + + + E+ F + V+ V+
Sbjct: 58  EMLFRCNYLALVGGGKKPKYPPNKVMIWDDLKKKTVIEIEFSTEVKAVK 106

>WIPI3_MOUSE (Q9CR39) WD-repeat domain phosphoinositide-interacting protein 3|
           (WIPI-3) (WD-repeat protein 45-like) (WDR45-like
           protein)
          Length = 344

 Score = 69.3 bits (168), Expect = 2e-12
 Identities = 30/49 (61%), Positives = 37/49 (75%)
 Frame = +2

Query: 143 EMLFRCNILALVGGGDAPHYPPNKVMIWDDHQSRCIGELSFKSPVRGVR 289
           EMLFRCN LALVGGG  P YPPNKVMIWDD + + + E+ F + V+ V+
Sbjct: 58  EMLFRCNYLALVGGGKKPKYPPNKVMIWDDLKKKTVIEIEFSTEVKAVK 106

>WIPI3_HUMAN (Q5MNZ6) WD-repeat domain phosphoinositide-interacting protein 3|
           (WIPI-3) (WD-repeat protein 45-like) (WDR45-like
           protein) (WIPI49-like protein)
          Length = 344

 Score = 69.3 bits (168), Expect = 2e-12
 Identities = 30/49 (61%), Positives = 37/49 (75%)
 Frame = +2

Query: 143 EMLFRCNILALVGGGDAPHYPPNKVMIWDDHQSRCIGELSFKSPVRGVR 289
           EMLFRCN LALVGGG  P YPPNKVMIWDD + + + E+ F + V+ V+
Sbjct: 58  EMLFRCNYLALVGGGKKPKYPPNKVMIWDDLKKKTVIEIEFSTEVKAVK 106

>WIPI3_CHICK (Q5ZL16) WD-repeat domain phosphoinositide-interacting protein 3|
           (WIPI-3) (WD-repeat protein 45-like) (WDR45-like
           protein)
          Length = 344

 Score = 69.3 bits (168), Expect = 2e-12
 Identities = 30/49 (61%), Positives = 37/49 (75%)
 Frame = +2

Query: 143 EMLFRCNILALVGGGDAPHYPPNKVMIWDDHQSRCIGELSFKSPVRGVR 289
           EMLFRCN LALVGGG  P YPPNKVMIWDD + + + E+ F + V+ V+
Sbjct: 58  EMLFRCNYLALVGGGKKPKYPPNKVMIWDDLKKKTVIEIEFSTEVKAVK 106

>WIPI3_BRARE (Q7ZUW6) WD-repeat domain phosphoinositide-interacting protein 3|
           (WIPI-3) (WD-repeat protein 45-like) (WDR45-like
           protein)
          Length = 344

 Score = 69.3 bits (168), Expect = 2e-12
 Identities = 30/49 (61%), Positives = 37/49 (75%)
 Frame = +2

Query: 143 EMLFRCNILALVGGGDAPHYPPNKVMIWDDHQSRCIGELSFKSPVRGVR 289
           EMLFRCN LALVGGG  P YPPNKVMIWDD + + + E+ F + V+ V+
Sbjct: 58  EMLFRCNYLALVGGGKKPKYPPNKVMIWDDLKKKTVIEIEFSTEVKAVK 106

>HSV2_SCHPO (Q9P3W2) SVP1-like protein 2|
          Length = 364

 Score = 56.2 bits (134), Expect = 2e-08
 Identities = 23/48 (47%), Positives = 33/48 (68%)
 Frame = +2

Query: 143 EMLFRCNILALVGGGDAPHYPPNKVMIWDDHQSRCIGELSFKSPVRGV 286
           +MLFR N+L LVGGG  P Y PNK+++WDD + R + EL     ++G+
Sbjct: 49  KMLFRSNVLLLVGGGGNPKYAPNKLIVWDDVKERPVKELELNFEIKGI 96

>HSV2_EMENI (Q5B464) SVP1-like protein 2|
          Length = 317

 Score = 52.4 bits (124), Expect = 3e-07
 Identities = 24/48 (50%), Positives = 33/48 (68%)
 Frame = +2

Query: 146 MLFRCNILALVGGGDAPHYPPNKVMIWDDHQSRCIGELSFKSPVRGVR 289
           ML + N LALVGGG  P +P NK++IWDD + + +  L F++ V GVR
Sbjct: 1   MLGQSNYLALVGGGRQPKFPQNKLVIWDDAKQKVVITLEFRTSVLGVR 48

>HSV2_YARLI (Q6CEI9) SVP1-like protein 2|
          Length = 359

 Score = 52.4 bits (124), Expect = 3e-07
 Identities = 25/48 (52%), Positives = 32/48 (66%)
 Frame = +2

Query: 143 EMLFRCNILALVGGGDAPHYPPNKVMIWDDHQSRCIGELSFKSPVRGV 286
           +ML R N LA+VGGG  P +P NK++IWDD +S+    L F SPV  V
Sbjct: 62  QMLHRTNYLAVVGGGSNPKFPQNKLVIWDDLKSKPALSLEFLSPVLNV 109

>HSV2_CANGA (Q6FXC1) SVP1-like protein 2|
          Length = 445

 Score = 50.8 bits (120), Expect = 9e-07
 Identities = 25/48 (52%), Positives = 31/48 (64%)
 Frame = +2

Query: 143 EMLFRCNILALVGGGDAPHYPPNKVMIWDDHQSRCIGELSFKSPVRGV 286
           +ML+R N +ALVGGG  P Y  N+V+IWDD Q +    L F S VR V
Sbjct: 67  QMLYRTNYIALVGGGQRPRYSLNRVVIWDDLQQKESFSLKFMSIVRKV 114

>WIPI4_XENLA (Q6DCV0) WD-repeat domain phosphoinositide-interacting protein 4|
           (WIPI-4) (WD-repeat protein 45)
          Length = 355

 Score = 50.4 bits (119), Expect = 1e-06
 Identities = 25/52 (48%), Positives = 32/52 (61%), Gaps = 3/52 (5%)
 Frame = +2

Query: 143 EMLFRCNILALVGGGDAPHYPPNKVMIWDDH---QSRCIGELSFKSPVRGVR 289
           EML RCN+LALVGGG  P +    V+IWDD    + + + E +F  PV  VR
Sbjct: 53  EMLHRCNLLALVGGGSNPKFSDISVLIWDDSRDGKDKLVLEFTFTKPVLSVR 104

>HSV2_CANAL (Q59P11) SVP1-like protein 2|
          Length = 595

 Score = 50.1 bits (118), Expect = 1e-06
 Identities = 23/47 (48%), Positives = 31/47 (65%)
 Frame = +2

Query: 146 MLFRCNILALVGGGDAPHYPPNKVMIWDDHQSRCIGELSFKSPVRGV 286
           ML R N LAL+GGG+ P +P NK++IWDD + +    L F +PV  V
Sbjct: 141 MLHRTNYLALIGGGENPKFPINKLIIWDDLKRKTSLSLEFDTPVLNV 187

>HSV2_ASHGO (Q75AQ4) SVP1-like protein 2|
          Length = 401

 Score = 49.7 bits (117), Expect = 2e-06
 Identities = 22/44 (50%), Positives = 28/44 (63%)
 Frame = +2

Query: 146 MLFRCNILALVGGGDAPHYPPNKVMIWDDHQSRCIGELSFKSPV 277
           ML+R N + LVGGG +P +  NK+ IWDD Q R    + F SPV
Sbjct: 67  MLYRTNYIGLVGGGASPRFSTNKIAIWDDIQQRDSVSIRFNSPV 110

>HSV2_PICAN (Q5QA93) SVP1-like protein 2|
          Length = 360

 Score = 47.8 bits (112), Expect = 7e-06
 Identities = 23/47 (48%), Positives = 29/47 (61%)
 Frame = +2

Query: 146 MLFRCNILALVGGGDAPHYPPNKVMIWDDHQSRCIGELSFKSPVRGV 286
           ML R N +ALVGGG  P +P NK+ IWDD + +    L F SP+  V
Sbjct: 64  MLHRTNYVALVGGGRQPRFPVNKLCIWDDLKKKPSIMLEFMSPILNV 110

>HSV2_DEBHA (Q6BUX9) SVP1-like protein 2|
          Length = 432

 Score = 47.0 bits (110), Expect = 1e-05
 Identities = 24/47 (51%), Positives = 29/47 (61%)
 Frame = +2

Query: 146 MLFRCNILALVGGGDAPHYPPNKVMIWDDHQSRCIGELSFKSPVRGV 286
           ML R N LALVGGG  P +  NK++IWDD + +    L F SPV  V
Sbjct: 68  MLHRTNYLALVGGGKNPKFANNKLVIWDDLKRKNSLNLEFMSPVLNV 114

>WIPI4_MOUSE (Q91VM3) WD-repeat domain phosphoinositide-interacting protein 4|
           (WIPI-4) (WD-repeat protein 45) (WD repeat domain
           X-linked 1)
          Length = 360

 Score = 46.6 bits (109), Expect = 2e-05
 Identities = 24/55 (43%), Positives = 32/55 (58%), Gaps = 6/55 (10%)
 Frame = +2

Query: 143 EMLFRCNILALVGGGDAPHYPPNKVMIWD------DHQSRCIGELSFKSPVRGVR 289
           EML R N+LALVGGG +P +    V+IWD      D + + + E +F  PV  VR
Sbjct: 55  EMLHRSNLLALVGGGSSPKFSEISVLIWDDAREGKDSKDKLVLEFTFTKPVLAVR 109

>WIPI4_HUMAN (Q9Y484) WD-repeat domain phosphoinositide-interacting protein 4|
           (WIPI-4) (WD-repeat protein 45)
          Length = 360

 Score = 46.6 bits (109), Expect = 2e-05
 Identities = 24/55 (43%), Positives = 32/55 (58%), Gaps = 6/55 (10%)
 Frame = +2

Query: 143 EMLFRCNILALVGGGDAPHYPPNKVMIWD------DHQSRCIGELSFKSPVRGVR 289
           EML R N+LALVGGG +P +    V+IWD      D + + + E +F  PV  VR
Sbjct: 55  EMLHRSNLLALVGGGSSPKFSEISVLIWDDAREGKDSKEKLVLEFTFTKPVLSVR 109

>WIPI4_RAT (Q5U2Y0) WD-repeat domain phosphoinositide-interacting protein 4|
           (WIPI-4) (WD-repeat protein 45)
          Length = 309

 Score = 46.6 bits (109), Expect = 2e-05
 Identities = 24/55 (43%), Positives = 32/55 (58%), Gaps = 6/55 (10%)
 Frame = +2

Query: 143 EMLFRCNILALVGGGDAPHYPPNKVMIWD------DHQSRCIGELSFKSPVRGVR 289
           EML R N+LALVGGG +P +    V+IWD      D + + + E +F  PV  VR
Sbjct: 55  EMLHRSNLLALVGGGSSPKFSEISVLIWDDAREGKDSKDKLVLEFTFTKPVLAVR 109

>HSV2_YEAST (P50079) SVP1-like protein 2|
          Length = 448

 Score = 44.3 bits (103), Expect = 8e-05
 Identities = 21/47 (44%), Positives = 29/47 (61%)
 Frame = +2

Query: 146 MLFRCNILALVGGGDAPHYPPNKVMIWDDHQSRCIGELSFKSPVRGV 286
           ML+R N +ALVGGG  P +  NK++IWDD   +    L F S ++ V
Sbjct: 73  MLYRTNYIALVGGGKRPRHALNKLIIWDDLLQKETITLKFMSSIKDV 119

>ATG18_YARLI (Q6C044) Autophagy-related protein 18|
          Length = 400

 Score = 43.1 bits (100), Expect = 2e-04
 Identities = 29/96 (30%), Positives = 42/96 (43%)
 Frame = +2

Query: 2   RIYNCDPFREIFRRDLGPSPAAPDNDQALHQPPXXXXXXXXXXXXXXEMLFRCNILALVG 181
           +IYNCDPF + F +  G                              EMLF  +++A+VG
Sbjct: 26  KIYNCDPFGKCFSKADG-------------------------GMGIVEMLFCTSLIAVVG 60

Query: 182 GGDAPHYPPNKVMIWDDHQSRCIGELSFKSPVRGVR 289
            GD P   P ++ I +  +   I EL+F + V GVR
Sbjct: 61  MGDQPQNSPRRLKIVNTKRQSTICELTFPTAVLGVR 96

>WIPI4_BRARE (Q7ZUX3) WD-repeat domain phosphoinositide-interacting protein 4|
           (WIPI-4) (WD-repeat protein 45)
          Length = 358

 Score = 40.8 bits (94), Expect = 9e-04
 Identities = 22/54 (40%), Positives = 30/54 (55%), Gaps = 6/54 (11%)
 Frame = +2

Query: 146 MLFRCNILALVGGGDAPHYPPNKVMIWD------DHQSRCIGELSFKSPVRGVR 289
           ML R N+LA+VGGG  P +    V+IWD      D + + + E +F  PV  VR
Sbjct: 54  MLHRSNLLAVVGGGVNPKFSEISVLIWDDAREVRDPKDKLVLEFTFTKPVLAVR 107

>ATG18_YEAST (P43601) Autophagy-related protein 18 (Cytoplasm to vacuole|
           targeting protein 18) (Swollen vacuole phenotype protein
           1) (Needed for premeiotic replication protein 1)
          Length = 500

 Score = 39.3 bits (90), Expect = 0.003
 Identities = 25/96 (26%), Positives = 41/96 (42%)
 Frame = +2

Query: 2   RIYNCDPFREIFRRDLGPSPAAPDNDQALHQPPXXXXXXXXXXXXXXEMLFRCNILALVG 181
           +I+NC+PF + +  D G                              EMLF  ++LALVG
Sbjct: 29  KIFNCEPFGKFYSEDSG-------------------------GYAIVEMLFSTSLLALVG 63

Query: 182 GGDAPHYPPNKVMIWDDHQSRCIGELSFKSPVRGVR 289
            GD P   P ++ I +  +   I E++F + +  V+
Sbjct: 64  IGDQPALSPRRLRIINTKKHSIICEVTFPTSILSVK 99

>ATG21_PICAN (Q5QJC0) Autophagy-related protein 21|
          Length = 388

 Score = 38.5 bits (88), Expect = 0.004
 Identities = 28/96 (29%), Positives = 43/96 (44%)
 Frame = +2

Query: 2   RIYNCDPFREIFRRDLGPSPAAPDNDQALHQPPXXXXXXXXXXXXXXEMLFRCNILALVG 181
           ++YNCDPF E F++       A D    L                  EMLF  +++A+VG
Sbjct: 24  KVYNCDPFGECFQK-------ADDGGANL-----------------VEMLFSTSLIAVVG 59

Query: 182 GGDAPHYPPNKVMIWDDHQSRCIGELSFKSPVRGVR 289
            GD P     K+ I +  +   I EL+F + +  V+
Sbjct: 60  IGDKPANTMRKLKIINTKRKAVICELTFPTAILYVK 95

>ATG18_CANGA (Q6FM63) Autophagy-related protein 18|
          Length = 505

 Score = 36.6 bits (83), Expect = 0.017
 Identities = 25/95 (26%), Positives = 39/95 (41%)
 Frame = +2

Query: 5   IYNCDPFREIFRRDLGPSPAAPDNDQALHQPPXXXXXXXXXXXXXXEMLFRCNILALVGG 184
           I+NC PF + +  D G                              EMLF  ++LALVG 
Sbjct: 30  IFNCAPFGKFYSEDSG-------------------------GYGIVEMLFSTSLLALVGI 64

Query: 185 GDAPHYPPNKVMIWDDHQSRCIGELSFKSPVRGVR 289
           GD P   P ++ I +  +   I E++F + +  V+
Sbjct: 65  GDQPMLSPRRLRIINTKKHSIICEVTFPTKILSVK 99

>ATG18_PICPA (Q8X1F5) Autophagy-related protein 18 (Glucose-induced selective|
           autophagy protein 12)
          Length = 543

 Score = 35.4 bits (80), Expect = 0.037
 Identities = 16/49 (32%), Positives = 30/49 (61%)
 Frame = +2

Query: 143 EMLFRCNILALVGGGDAPHYPPNKVMIWDDHQSRCIGELSFKSPVRGVR 289
           EMLF  +++A+VG G+ P   P K+ +++  +   I EL+F + +  V+
Sbjct: 65  EMLFSSSLVAIVGLGELPDSSPRKLKVFNTKRRSIICELTFPTSILAVK 113

>ATG18_PICAN (Q5QA94) Autophagy-related protein 18|
          Length = 525

 Score = 34.7 bits (78), Expect = 0.064
 Identities = 23/96 (23%), Positives = 39/96 (40%)
 Frame = +2

Query: 2   RIYNCDPFREIFRRDLGPSPAAPDNDQALHQPPXXXXXXXXXXXXXXEMLFRCNILALVG 181
           +IYNC+PF + + +  G                              EMLF  ++LA+VG
Sbjct: 55  KIYNCEPFGQCYSKSDG-------------------------SIGIVEMLFSSSLLAIVG 89

Query: 182 GGDAPHYPPNKVMIWDDHQSRCIGELSFKSPVRGVR 289
            G+     P ++ I +  +   I EL+F   +  V+
Sbjct: 90  MGEQHSLSPRRLKIINTKRQTTICELTFPGAILAVK 125

>ATG21_CANGA (Q6FRU4) Autophagy-related protein 21|
          Length = 453

 Score = 32.3 bits (72), Expect = 0.32
 Identities = 23/89 (25%), Positives = 38/89 (42%)
 Frame = +2

Query: 5   IYNCDPFREIFRRDLGPSPAAPDNDQALHQPPXXXXXXXXXXXXXXEMLFRCNILALVGG 184
           +YNCDPF + F  ++  +     ND  +                  EMLF  ++LA+V  
Sbjct: 24  VYNCDPFGKCFEFNIS-NVNGDSNDNGIGYDSLEAGSSSIESQVIAEMLFSTSLLAVVDK 82

Query: 185 GDAPHYPPNKVMIWDDHQSRCIGELSFKS 271
           G   +    K+ I +  +   I E++F S
Sbjct: 83  GQGIN-TGKKLKIVNIKKRSLICEIAFPS 110

>ATG18_SCHPO (Q9HDZ7) Autophagy-related protein 18|
          Length = 373

 Score = 32.0 bits (71), Expect = 0.41
 Identities = 25/96 (26%), Positives = 40/96 (41%)
 Frame = +2

Query: 2   RIYNCDPFREIFRRDLGPSPAAPDNDQALHQPPXXXXXXXXXXXXXXEMLFRCNILALVG 181
           +IYNCDPF + F +  G                              EMLF  +++ALV 
Sbjct: 24  KIYNCDPFGKCFHKIQG-------------------------ATSIVEMLFSTSLVALVE 58

Query: 182 GGDAPHYPPNKVMIWDDHQSRCIGELSFKSPVRGVR 289
             D  +    K+ + +  +S  I EL+F +P+  V+
Sbjct: 59  KDDGNN---RKLKLINTKKSTTICELTFPTPLLAVK 91

>EFHC1_MOUSE (Q9D9T8) EF-hand domain-containing protein 1|
          Length = 648

 Score = 29.3 bits (64), Expect = 2.7
 Identities = 13/32 (40%), Positives = 16/32 (50%)
 Frame = +2

Query: 5   IYNCDPFREIFRRDLGPSPAAPDNDQALHQPP 100
           IY+CDPF   F +D    P  P  D    +PP
Sbjct: 344 IYDCDPFTRQFYKDKFGMPDLPPVDVTKKEPP 375

>ATG18_DEBHA (Q6BIL4) Autophagy-related protein 18|
          Length = 562

 Score = 28.9 bits (63), Expect = 3.5
 Identities = 16/49 (32%), Positives = 27/49 (55%)
 Frame = +2

Query: 143 EMLFRCNILALVGGGDAPHYPPNKVMIWDDHQSRCIGELSFKSPVRGVR 289
           EML+  +++A+VG G+     P K+ I +  +   I EL F S +  V+
Sbjct: 84  EMLYCTSLIAIVGLGEEVGSSPRKLKIINTRRQSTICELIFPSTILQVK 132

>WHRN_MOUSE (Q80VW5) Whirlin|
          Length = 906

 Score = 28.9 bits (63), Expect = 3.5
 Identities = 19/46 (41%), Positives = 21/46 (45%), Gaps = 13/46 (28%)
 Frame = +1

Query: 193 PALPAQQGHD--LGRP-------PEPL----HRGALLQVPRPRRPP 291
           P  P  QGHD  LG+P       P PL    H G +   PR R PP
Sbjct: 585 PPPPLAQGHDRLLGQPRKPGREDPAPLSSAAHSGIVFSAPRNRSPP 630

>MMP15_MOUSE (O54732) Matrix metalloproteinase-15 precursor (EC 3.4.24.-)|
           (MMP-15) (Membrane-type matrix metalloproteinase 2)
           (MT-MMP 2) (MTMMP2) (Membrane-type-2 matrix
           metalloproteinase) (MT2-MMP) (MT2MMP)
          Length = 657

 Score = 28.5 bits (62), Expect = 4.6
 Identities = 13/33 (39%), Positives = 16/33 (48%)
 Frame = +1

Query: 193 PALPAQQGHDLGRPPEPLHRGALLQVPRPRRPP 291
           P  P +  H   RPP+P H G      +P RPP
Sbjct: 317 PRRPGRPDHQPPRPPQPPHPGG-----KPERPP 344


  Database: uniprot_sprot.fasta
    Posted date:  May 25, 2006  5:36 PM
  Number of letters in database: 80,573,946
  Number of sequences in database:  219,361
  
Lambda     K      H
   0.318    0.135    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,064,216
Number of Sequences: 219361
Number of extensions: 420016
Number of successful extensions: 1571
Number of sequences better than 10.0: 33
Number of HSP's better than 10.0 without gapping: 1535
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 1570
length of database: 80,573,946
effective HSP length: 72
effective length of database: 64,779,954
effective search space used: 1554718896
frameshift window, decay const: 50,  0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)