ナショナルバイオリソースプロジェクト
-Barley Genetic Resources Database-
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| Clone Name | bast73g08 |
|---|---|
| Clone Library Name | barley_pub |
>NAK_ARATH (P43293) Probable serine/threonine-protein kinase NAK (EC 2.7.11.1)| Length = 389 Score = 173 bits (439), Expect = 2e-43 Identities = 87/146 (59%), Positives = 113/146 (77%), Gaps = 1/146 (0%) Frame = +2 Query: 11 RCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFK 190 R LV+E + GS+E+HL Y PL ++TR+++ALGAARGLA+LH +A P VI+RDFK Sbjct: 147 RLLVYEFMTRGSLENHLFRRGTFYQPLSWNTRVRMALGAARGLAFLH-NAQPQVIYRDFK 205 Query: 191 ASNVLLENDFTAKVADFGLAKEASEGIE-HISTQVMGTFGYVAPEYAMTGHLLVKSDVYS 367 ASN+LL++++ AK++DFGLA++ G H+ST+VMGT GY APEY TGHL VKSDVYS Sbjct: 206 ASNILLDSNYNAKLSDFGLARDGPMGDNSHVSTRVMGTQGYAAPEYLATGHLSVKSDVYS 265 Query: 368 YGVVLLELLSGRKPVDMTQPSGSENL 445 +GVVLLELLSGR+ +D QP G NL Sbjct: 266 FGVVLLELLSGRRAIDKNQPVGEHNL 291
>PBS1_ARATH (Q9FE20) Serine/threonine-protein kinase PBS1 (EC 2.7.11.1)| (AvrPphB susceptible protein 1) Length = 456 Score = 172 bits (435), Expect = 4e-43 Identities = 86/146 (58%), Positives = 109/146 (74%), Gaps = 1/146 (0%) Frame = +2 Query: 11 RCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFK 190 R LV+E +P GS+E HLH LD++ RMKIA GAA+GL +LH+ ANP VI+RDFK Sbjct: 156 RLLVYEFMPLGSLEDHLHDLPPDKEALDWNMRMKIAAGAAKGLEFLHDKANPPVIYRDFK 215 Query: 191 ASNVLLENDFTAKVADFGLAKEASEGIE-HISTQVMGTFGYVAPEYAMTGHLLVKSDVYS 367 +SN+LL+ F K++DFGLAK G + H+ST+VMGT+GY APEYAMTG L VKSDVYS Sbjct: 216 SSNILLDEGFHPKLSDFGLAKLGPTGDKSHVSTRVMGTYGYCAPEYAMTGQLTVKSDVYS 275 Query: 368 YGVVLLELLSGRKPVDMTQPSGSENL 445 +GVV LEL++GRK +D P G +NL Sbjct: 276 FGVVFLELITGRKAIDSEMPHGEQNL 301
>APK1B_ARATH (P46573) Protein kinase APK1B, chloroplast precursor (EC 2.7.11.1)| Length = 412 Score = 169 bits (428), Expect = 3e-42 Identities = 82/146 (56%), Positives = 111/146 (76%), Gaps = 1/146 (0%) Frame = +2 Query: 11 RCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFK 190 R LV+E +P GS+E+HL + PL + R+K+ALGAA+GLA+LH +A VI+RDFK Sbjct: 148 RLLVYEFMPRGSLENHLFRRGSYFQPLSWTLRLKVALGAAKGLAFLH-NAETSVIYRDFK 206 Query: 191 ASNVLLENDFTAKVADFGLAKEASEGIE-HISTQVMGTFGYVAPEYAMTGHLLVKSDVYS 367 SN+LL++++ AK++DFGLAK+ G + H+ST++MGT+GY APEY TGHL KSDVYS Sbjct: 207 TSNILLDSEYNAKLSDFGLAKDGPTGDKSHVSTRIMGTYGYAAPEYLATGHLTTKSDVYS 266 Query: 368 YGVVLLELLSGRKPVDMTQPSGSENL 445 YGVVLLE+LSGR+ VD +P G + L Sbjct: 267 YGVVLLEVLSGRRAVDKNRPPGEQKL 292
>APK1A_ARATH (Q06548) Protein kinase APK1A, chloroplast precursor (EC 2.7.11.1)| Length = 410 Score = 168 bits (426), Expect = 5e-42 Identities = 84/146 (57%), Positives = 110/146 (75%), Gaps = 1/146 (0%) Frame = +2 Query: 11 RCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFK 190 R LV+E +P GS+E+HL + PL + R+K+ALGAA+GLA+LH + VI+RDFK Sbjct: 147 RLLVYEFMPRGSLENHLFRRGLYFQPLSWKLRLKVALGAAKGLAFLHS-SETRVIYRDFK 205 Query: 191 ASNVLLENDFTAKVADFGLAKEASEGIE-HISTQVMGTFGYVAPEYAMTGHLLVKSDVYS 367 SN+LL++++ AK++DFGLAK+ G + H+ST+VMGT GY APEY TGHL KSDVYS Sbjct: 206 TSNILLDSEYNAKLSDFGLAKDGPIGDKSHVSTRVMGTHGYAAPEYLATGHLTTKSDVYS 265 Query: 368 YGVVLLELLSGRKPVDMTQPSGSENL 445 +GVVLLELLSGR+ VD +PSG NL Sbjct: 266 FGVVLLELLSGRRAVDKNRPSGERNL 291
>RLCK7_ARATH (Q9LQQ8) Probable serine/threonine-protein kinase RLCKVII (EC| 2.7.11.1) Length = 423 Score = 168 bits (425), Expect = 6e-42 Identities = 84/146 (57%), Positives = 107/146 (73%), Gaps = 1/146 (0%) Frame = +2 Query: 11 RCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFK 190 R LV+E +P GS+E HLH PLD++TRMKIA GAARGL YLH+ P VI+RD K Sbjct: 173 RLLVYEYMPQGSLEDHLHVLPSGKKPLDWNTRMKIAAGAARGLEYLHDRMTPPVIYRDLK 232 Query: 191 ASNVLLENDFTAKVADFGLAKEASEGIE-HISTQVMGTFGYVAPEYAMTGHLLVKSDVYS 367 SN+LL D+ K++DFGLAK G + H+ST+VMGT+GY AP+YAMTG L KSD+YS Sbjct: 233 CSNILLGEDYQPKLSDFGLAKVGPSGDKTHVSTRVMGTYGYCAPDYAMTGQLTFKSDIYS 292 Query: 368 YGVVLLELLSGRKPVDMTQPSGSENL 445 +GVVLLEL++GRK +D T+ +NL Sbjct: 293 FGVVLLELITGRKAIDNTKTRKDQNL 318
>PSKR_DAUCA (Q8LPB4) Phytosulfokine receptor precursor (EC 2.7.11.1)| (Phytosulfokine LRR receptor kinase) Length = 1021 Score = 149 bits (377), Expect = 2e-36 Identities = 72/150 (48%), Positives = 104/150 (69%), Gaps = 2/150 (1%) Frame = +2 Query: 2 RRTRCLVFELVPNGSVESHLHGSDKIYGP--LDFDTRMKIALGAARGLAYLHEDANPHVI 175 + + L++ + NGS++ LH +K+ GP LD+ TR++IA GAA GLAYLH+ PH++ Sbjct: 809 KNDKLLIYSYMDNGSLDYWLH--EKVDGPPSLDWKTRLRIARGAAEGLAYLHQSCEPHIL 866 Query: 176 HRDFKASNVLLENDFTAKVADFGLAKEASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKS 355 HRD K+SN+LL + F A +ADFGLA+ H++T ++GT GY+ PEY K Sbjct: 867 HRDIKSSNILLSDTFVAHLADFGLARLILPYDTHVTTDLVGTLGYIPPEYGQASVATYKG 926 Query: 356 DVYSYGVVLLELLSGRKPVDMTQPSGSENL 445 DVYS+GVVLLELL+GR+P+D+ +P GS +L Sbjct: 927 DVYSFGVVLLELLTGRRPMDVCKPRGSRDL 956
>PSKR_ARATH (Q9ZVR7) Putative phytosulfokine receptor precursor (EC 2.7.11.1)| (Phytosulfokine LRR receptor kinase) Length = 1008 Score = 146 bits (368), Expect = 3e-35 Identities = 69/148 (46%), Positives = 100/148 (67%) Frame = +2 Query: 2 RRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHR 181 + R L++ + NGS++ LH + L + TR++IA GAA+GL YLHE +PH++HR Sbjct: 800 KNDRLLIYSYMENGSLDYWLHERNDGPALLKWKTRLRIAQGAAKGLLYLHEGCDPHILHR 859 Query: 182 DFKASNVLLENDFTAKVADFGLAKEASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDV 361 D K+SN+LL+ +F + +ADFGLA+ S H+ST ++GT GY+ PEY K DV Sbjct: 860 DIKSSNILLDENFNSHLADFGLARLMSPYETHVSTDLVGTLGYIPPEYGQASVATYKGDV 919 Query: 362 YSYGVVLLELLSGRKPVDMTQPSGSENL 445 YS+GVVLLELL+ ++PVDM +P G +L Sbjct: 920 YSFGVVLLELLTDKRPVDMCKPKGCRDL 947
>CX32_ARATH (P27450) Probable serine/threonine-protein kinase Cx32, chloroplast| precursor (EC 2.7.11.1) Length = 419 Score = 145 bits (367), Expect = 3e-35 Identities = 74/144 (51%), Positives = 106/144 (73%), Gaps = 1/144 (0%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 LV+E +P GS+ESHL + P +D R+KI +GAARGLA+LH VI+RDFKAS Sbjct: 167 LVYEFMPKGSLESHLFRRND---PFPWDLRIKIVIGAARGLAFLHS-LQREVIYRDFKAS 222 Query: 197 NVLLENDFTAKVADFGLAKEA-SEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYSYG 373 N+LL++++ AK++DFGLAK ++ H++T++MGT+GY APEY TGHL VKSDV+++G Sbjct: 223 NILLDSNYDAKLSDFGLAKLGPADEKSHVTTRIMGTYGYAAPEYMATGHLYVKSDVFAFG 282 Query: 374 VVLLELLSGRKPVDMTQPSGSENL 445 VVLLE+++G + +P G E+L Sbjct: 283 VVLLEIMTGLTAHNTKRPRGQESL 306
>EXS_ARATH (Q9LYN8) Leucine-rich repeat receptor protein kinase EXS precursor| (EC 2.7.11.1) (Extra sporogenous cells protein) (EXCESS MICROSPOROCYTES1 protein) Length = 1192 Score = 145 bits (365), Expect = 6e-35 Identities = 69/133 (51%), Positives = 93/133 (69%) Frame = +2 Query: 11 RCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFK 190 + LV+E + NGS++ L + LD+ R+KIA+GAARGLA+LH PH+IHRD K Sbjct: 986 KLLVYEYMVNGSLDHWLRNQTGMLEVLDWSKRLKIAVGAARGLAFLHHGFIPHIIHRDIK 1045 Query: 191 ASNVLLENDFTAKVADFGLAKEASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYSY 370 ASN+LL+ DF KVADFGLA+ S H+ST + GTFGY+ PEY + K DVYS+ Sbjct: 1046 ASNILLDGDFEPKVADFGLARLISACESHVSTVIAGTFGYIPPEYGQSARATTKGDVYSF 1105 Query: 371 GVVLLELLSGRKP 409 GV+LLEL++G++P Sbjct: 1106 GVILLELVTGKEP 1118
>BRL3_ARATH (Q9LJF3) Serine/threonine-protein kinase BRI1-like 3 precursor (EC| 2.7.11.1) (BRASSINOSTEROID INSENSITIVE 1-like protein 3) Length = 1164 Score = 143 bits (360), Expect = 2e-34 Identities = 77/147 (52%), Positives = 98/147 (66%), Gaps = 2/147 (1%) Frame = +2 Query: 11 RCLVFELVPNGSVESHLHGSDKIYGP-LDFDTRMKIALGAARGLAYLHEDANPHVIHRDF 187 R LV+E + GS+E+ LH K G LD+ R KIA+GAARGLA+LH PH+IHRD Sbjct: 927 RLLVYEYMKYGSLETVLHEKTKKGGIFLDWSARKKIAIGAARGLAFLHHSCIPHIIHRDM 986 Query: 188 KASNVLLENDFTAKVADFGLAKEASEGIEHISTQVM-GTFGYVAPEYAMTGHLLVKSDVY 364 K+SNVLL+ DF A+V+DFG+A+ S H+S + GT GYV PEY + K DVY Sbjct: 987 KSSNVLLDQDFVARVSDFGMARLVSALDTHLSVSTLAGTPGYVPPEYYQSFRCTAKGDVY 1046 Query: 365 SYGVVLLELLSGRKPVDMTQPSGSENL 445 SYGV+LLELLSG+KP+D + NL Sbjct: 1047 SYGVILLELLSGKKPIDPEEFGEDNNL 1073
>TMK1_ARATH (P43298) Putative receptor protein kinase TMK1 precursor (EC| 2.7.11.1) Length = 942 Score = 141 bits (355), Expect = 8e-34 Identities = 73/146 (50%), Positives = 101/146 (69%), Gaps = 1/146 (0%) Frame = +2 Query: 11 RCLVFELVPNGSVESHL-HGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDF 187 + LV+E +P G++ HL S++ PL + R+ +AL ARG+ YLH A+ IHRD Sbjct: 659 KLLVYEYMPQGTLSRHLFEWSEEGLKPLLWKQRLTLALDVARGVEYLHGLAHQSFIHRDL 718 Query: 188 KASNVLLENDFTAKVADFGLAKEASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYS 367 K SN+LL +D AKVADFGL + A EG I T++ GTFGY+APEYA+TG + K DVYS Sbjct: 719 KPSNILLGDDMRAKVADFGLVRLAPEGKGSIETRIAGTFGYLAPEYAVTGRVTTKVDVYS 778 Query: 368 YGVVLLELLSGRKPVDMTQPSGSENL 445 +GV+L+EL++GRK +D +QP S +L Sbjct: 779 FGVILMELITGRKSLDESQPEESIHL 804
>CLV1_ARATH (Q9SYQ8) Receptor protein kinase CLAVATA1 precursor (EC 2.7.11.1)| Length = 980 Score = 139 bits (350), Expect = 3e-33 Identities = 70/136 (51%), Positives = 99/136 (72%), Gaps = 1/136 (0%) Frame = +2 Query: 8 TRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDF 187 T L++E +PNGS+ LHGS G L ++TR ++A+ AA+GL YLH D +P ++HRD Sbjct: 761 TNLLLYEYMPNGSLGELLHGSKG--GHLQWETRHRVAVEAAKGLCYLHHDCSPLILHRDV 818 Query: 188 KASNVLLENDFTAKVADFGLAKEASEG-IEHISTQVMGTFGYVAPEYAMTGHLLVKSDVY 364 K++N+LL++DF A VADFGLAK +G + + G++GY+APEYA T + KSDVY Sbjct: 819 KSNNILLDSDFEAHVADFGLAKFLVDGAASECMSSIAGSYGYIAPEYAYTLKVDEKSDVY 878 Query: 365 SYGVVLLELLSGRKPV 412 S+GVVLLEL++G+KPV Sbjct: 879 SFGVVLLELIAGKKPV 894
>BAK1_ARATH (Q94F62) BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1| precursor (EC 2.7.11.1) (BRI1-associated receptor kinase 1) (Somatic embryogenesis receptor-like kinase 3) Length = 615 Score = 138 bits (348), Expect = 5e-33 Identities = 68/145 (46%), Positives = 98/145 (67%) Frame = +2 Query: 11 RCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFK 190 R LV+ + NGSV S L + PLD+ R +IALG+ARGLAYLH+ +P +IHRD K Sbjct: 359 RLLVYPYMANGSVASCLRERPESQPPLDWPKRQRIALGSARGLAYLHDHCDPKIIHRDVK 418 Query: 191 ASNVLLENDFTAKVADFGLAKEASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYSY 370 A+N+LL+ +F A V DFGLAK H++T V GT G++APEY TG K+DV+ Y Sbjct: 419 AANILLDEEFEAVVGDFGLAKLMDYKDTHVTTAVRGTIGHIAPEYLSTGKSSEKTDVFGY 478 Query: 371 GVVLLELLSGRKPVDMTQPSGSENL 445 GV+LLEL++G++ D+ + + +++ Sbjct: 479 GVMLLELITGQRAFDLARLANDDDV 503
>BRI1_ARATH (O22476) BRASSINOSTEROID INSENSITIVE 1 precursor (EC 2.7.11.1)| (AtBRI1) (Brassinosteroid LRR receptor kinase) Length = 1196 Score = 137 bits (346), Expect = 9e-33 Identities = 73/146 (50%), Positives = 98/146 (67%), Gaps = 1/146 (0%) Frame = +2 Query: 11 RCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFK 190 R LV+E + GS+E LH K L++ TR KIA+G+ARGLA+LH + +PH+IHRD K Sbjct: 952 RLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAFLHHNCSPHIIHRDMK 1011 Query: 191 ASNVLLENDFTAKVADFGLAKEASEGIEHISTQVM-GTFGYVAPEYAMTGHLLVKSDVYS 367 +SNVLL+ + A+V+DFG+A+ S H+S + GT GYV PEY + K DVYS Sbjct: 1012 SSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPEYYQSFRCSTKGDVYS 1071 Query: 368 YGVVLLELLSGRKPVDMTQPSGSENL 445 YGVVLLELL+G++P D + G NL Sbjct: 1072 YGVVLLELLTGKRPTD-SPDFGDNNL 1096
>BRL1_ARATH (Q9ZWC8) Serine/threonine-protein kinase BRI1-like 1 precursor (EC| 2.7.11.1) (BRASSINOSTEROID INSENSITIVE 1-like protein 1) Length = 1166 Score = 137 bits (346), Expect = 9e-33 Identities = 75/148 (50%), Positives = 97/148 (65%), Gaps = 3/148 (2%) Frame = +2 Query: 11 RCLVFELVPNGSVESHLHGSDKIYGP--LDFDTRMKIALGAARGLAYLHEDANPHVIHRD 184 R LV+E + GS+E+ LH G L++ R KIA+GAARGLA+LH PH+IHRD Sbjct: 928 RLLVYEYMKWGSLETVLHEKSSKKGGIYLNWAARKKIAIGAARGLAFLHHSCIPHIIHRD 987 Query: 185 FKASNVLLENDFTAKVADFGLAKEASEGIEHISTQVM-GTFGYVAPEYAMTGHLLVKSDV 361 K+SNVLL+ DF A+V+DFG+A+ S H+S + GT GYV PEY + K DV Sbjct: 988 MKSSNVLLDEDFEARVSDFGMARLVSALDTHLSVSTLAGTPGYVPPEYYQSFRCTAKGDV 1047 Query: 362 YSYGVVLLELLSGRKPVDMTQPSGSENL 445 YSYGV+LLELLSG+KP+D + NL Sbjct: 1048 YSYGVILLELLSGKKPIDPGEFGEDNNL 1075
>NORK_PEA (Q8LKZ1) Nodulation receptor kinase precursor (EC 2.7.11.1)| Length = 924 Score = 135 bits (341), Expect = 4e-32 Identities = 72/138 (52%), Positives = 96/138 (69%), Gaps = 1/138 (0%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 LV+ + NGS+ L+G LD+ TR+ IALGAARGLAYLH VIHRD K+S Sbjct: 666 LVYPFMSNGSLLDRLYGEPAKRKILDWPTRLSIALGAARGLAYLHTFPGRSVIHRDVKSS 725 Query: 197 NVLLENDFTAKVADFGLAKEA-SEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYSYG 373 N+LL++ AKVADFG +K A EG ++S +V GT GY+ PEY T L KSDV+S+G Sbjct: 726 NILLDHSMCAKVADFGFSKYAPQEGDSYVSLEVRGTAGYLDPEYYKTQQLSEKSDVFSFG 785 Query: 374 VVLLELLSGRKPVDMTQP 427 VVLLE++SGR+P+++ +P Sbjct: 786 VVLLEIVSGREPLNIKRP 803
>BRI1_LYCES (Q8GUQ5) Brassinosteroid LRR receptor kinase precursor (EC 2.7.11.1)| (tBRI1) (Altered brassinolide sensitivity 1) (Systemin receptor SR160) Length = 1207 Score = 135 bits (341), Expect = 4e-32 Identities = 74/146 (50%), Positives = 97/146 (66%), Gaps = 1/146 (0%) Frame = +2 Query: 11 RCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFK 190 R LV+E + GS+E LH KI L++ R KIA+GAARGLA+LH + PH+IHRD K Sbjct: 957 RLLVYEYMKYGSLEDVLHDRKKIGIKLNWPARRKIAIGAARGLAFLHHNCIPHIIHRDMK 1016 Query: 191 ASNVLLENDFTAKVADFGLAKEASEGIEHISTQVM-GTFGYVAPEYAMTGHLLVKSDVYS 367 +SNVLL+ + A+V+DFG+A+ S H+S + GT GYV PEY + K DVYS Sbjct: 1017 SSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPEYYQSFRCSTKGDVYS 1076 Query: 368 YGVVLLELLSGRKPVDMTQPSGSENL 445 YGVVLLELL+G++P D + G NL Sbjct: 1077 YGVVLLELLTGKQPTD-SADFGDNNL 1101
>NORK_MEDTR (Q8L4H4) Nodulation receptor kinase precursor (EC 2.7.11.1) (Does not| make infections protein 2) (Symbiosis receptor-like kinase) (MtSYMRK) Length = 925 Score = 135 bits (340), Expect = 5e-32 Identities = 72/138 (52%), Positives = 95/138 (68%), Gaps = 1/138 (0%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 LV+ + NGS+ L+G LD+ TR+ IALGAARGLAYLH VIHRD K+S Sbjct: 667 LVYPFMSNGSLLDRLYGEASKRKILDWPTRLSIALGAARGLAYLHTFPGRSVIHRDVKSS 726 Query: 197 NVLLENDFTAKVADFGLAKEA-SEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYSYG 373 N+LL+ AKVADFG +K A EG ++S +V GT GY+ PEY T L KSDV+S+G Sbjct: 727 NILLDQSMCAKVADFGFSKYAPQEGDSYVSLEVRGTAGYLDPEYYKTQQLSEKSDVFSFG 786 Query: 374 VVLLELLSGRKPVDMTQP 427 VVLLE++SGR+P+++ +P Sbjct: 787 VVLLEIVSGREPLNIKRP 804
>BRI1_LYCPE (Q8L899) Systemin receptor SR160 precursor (EC 2.7.11.1)| (Brassinosteroid LRR receptor kinase) Length = 1207 Score = 134 bits (336), Expect = 1e-31 Identities = 73/146 (50%), Positives = 96/146 (65%), Gaps = 1/146 (0%) Frame = +2 Query: 11 RCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFK 190 R LV+E + GS+E LH K L++ R KIA+GAARGLA+LH + PH+IHRD K Sbjct: 957 RLLVYEYMKYGSLEDVLHDRKKTGIKLNWPARRKIAIGAARGLAFLHHNCIPHIIHRDMK 1016 Query: 191 ASNVLLENDFTAKVADFGLAKEASEGIEHISTQVM-GTFGYVAPEYAMTGHLLVKSDVYS 367 +SNVLL+ + A+V+DFG+A+ S H+S + GT GYV PEY + K DVYS Sbjct: 1017 SSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPEYYQSFRCSTKGDVYS 1076 Query: 368 YGVVLLELLSGRKPVDMTQPSGSENL 445 YGVVLLELL+G++P D + G NL Sbjct: 1077 YGVVLLELLTGKQPTD-SADFGDNNL 1101
>RLK5_ARATH (P47735) Receptor-like protein kinase 5 precursor (EC 2.7.11.1)| Length = 999 Score = 131 bits (329), Expect = 9e-31 Identities = 69/139 (49%), Positives = 97/139 (69%), Gaps = 4/139 (2%) Frame = +2 Query: 11 RCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFK 190 + LV+E +PNGS+ LHG K L + R++IAL AA GL+YLH D P ++HRD K Sbjct: 762 KLLVYEYMPNGSLADVLHGDRKGGVVLGWPERLRIALDAAEGLSYLHHDCVPPIVHRDVK 821 Query: 191 ASNVLLENDFTAKVADFGLAK----EASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSD 358 +SN+LL++D+ AKVADFG+AK S+ E +S + G+ GY+APEY T + KSD Sbjct: 822 SSNILLDSDYGAKVADFGIAKVGQMSGSKTPEAMS-GIAGSCGYIAPEYVYTLRVNEKSD 880 Query: 359 VYSYGVVLLELLSGRKPVD 415 +YS+GVVLLEL++G++P D Sbjct: 881 IYSFGVVLLELVTGKQPTD 899
>CRI4_MAIZE (O24585) Putative receptor protein kinase CRINKLY4 precursor (EC| 2.7.11.1) Length = 901 Score = 127 bits (319), Expect = 1e-29 Identities = 72/145 (49%), Positives = 95/145 (65%), Gaps = 3/145 (2%) Frame = +2 Query: 11 RCLVFELVPNGSVESHLHGSD-KIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDF 187 R LV+E + +GS+ HLHG D + L++ R+ IA+ AARG+ YLH A P VIHRD Sbjct: 576 RLLVYEFMAHGSLYQHLHGKDPNLKKRLNWARRVTIAVQAARGIEYLHGYACPPVIHRDI 635 Query: 188 KASNVLLENDFTAKVADFGLA--KEASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDV 361 K+SN+L++ D A+VADFGL+ A G +S GT GY+ PEY +L KSDV Sbjct: 636 KSSNILIDEDHNARVADFGLSILGPADSGTP-LSELPAGTLGYLDPEYYRLHYLTTKSDV 694 Query: 362 YSYGVVLLELLSGRKPVDMTQPSGS 436 YS+GVVLLE+LSGRK +DM G+ Sbjct: 695 YSFGVVLLEILSGRKAIDMQFEEGN 719
>BRL2_ARATH (Q9ZPS9) Serine/threonine-protein kinase BRI1-like 2 precursor (EC| 2.7.11.1) (BRASSINOSTEROID INSENSITIVE 1-like protein 2) (Protein VASCULAR HIGHWAY 1) Length = 1143 Score = 125 bits (314), Expect = 5e-29 Identities = 70/148 (47%), Positives = 95/148 (64%), Gaps = 3/148 (2%) Frame = +2 Query: 11 RCLVFELVPNGSVESHLHG--SDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRD 184 R LV+E + GS+E LHG + + L ++ R KIA GAA+GL +LH + PH+IHRD Sbjct: 907 RLLVYEFMQYGSLEEVLHGPRTGEKRRILGWEERKKIAKGAAKGLCFLHHNCIPHIIHRD 966 Query: 185 FKASNVLLENDFTAKVADFGLAKEASEGIEHISTQVM-GTFGYVAPEYAMTGHLLVKSDV 361 K+SNVLL+ D A+V+DFG+A+ S H+S + GT GYV PEY + K DV Sbjct: 967 MKSSNVLLDQDMEARVSDFGMARLISALDTHLSVSTLAGTPGYVPPEYYQSFRCTAKGDV 1026 Query: 362 YSYGVVLLELLSGRKPVDMTQPSGSENL 445 YS GVV+LE+LSG++P D + G NL Sbjct: 1027 YSIGVVMLEILSGKRPTD-KEEFGDTNL 1053
>IRAK4_MOUSE (Q8R4K2) Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1)| (IRAK-4) Length = 459 Score = 119 bits (298), Expect = 3e-27 Identities = 64/135 (47%), Positives = 93/135 (68%), Gaps = 1/135 (0%) Frame = +2 Query: 14 CLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKA 193 CLV+ +PNGS+ L D PL + TR K+A G A G+ +LHE+ H IHRD K+ Sbjct: 259 CLVYAYMPNGSLLDRLSCLDGT-PPLSWHTRCKVAQGTANGIRFLHEN---HHIHRDIKS 314 Query: 194 SNVLLENDFTAKVADFGLAKEASEGIEHIST-QVMGTFGYVAPEYAMTGHLLVKSDVYSY 370 +N+LL+ DFTAK++DFGLA+ ++ + + T +++GT Y+APE A+ G + KSD+YS+ Sbjct: 315 ANILLDKDFTAKISDFGLARASARLAQTVMTSRIVGTTAYMAPE-ALRGEITPKSDIYSF 373 Query: 371 GVVLLELLSGRKPVD 415 GVVLLEL++G VD Sbjct: 374 GVVLLELITGLAAVD 388
>RPK1_IPONI (P93194) Receptor-like protein kinase precursor (EC 2.7.11.1)| Length = 1109 Score = 116 bits (291), Expect = 2e-26 Identities = 62/134 (46%), Positives = 87/134 (64%), Gaps = 1/134 (0%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 +++ + NGS+ LH ++ PLD+ TR IA+G A GLAYLH D +P ++HRD K Sbjct: 888 ILYTYMENGSLHDILHETNPPK-PLDWSTRHNIAVGTAHGLAYLHFDCDPAIVHRDIKPM 946 Query: 197 NVLLENDFTAKVADFGLAKEASEGIEHI-STQVMGTFGYVAPEYAMTGHLLVKSDVYSYG 373 N+LL++D ++DFG+AK + I S V GT GY+APE A T +SDVYSYG Sbjct: 947 NILLDSDLEPHISDFGIAKLLDQSATSIPSNTVQGTIGYMAPENAFTTVKSRESDVYSYG 1006 Query: 374 VVLLELLSGRKPVD 415 VVLLEL++ +K +D Sbjct: 1007 VVLLELITRKKALD 1020
>SRK6_BRAOE (Q09092) Putative serine/threonine-protein kinase receptor| precursor (EC 2.7.11.1) (S-receptor kinase) (SRK) Length = 849 Score = 115 bits (287), Expect = 6e-26 Identities = 59/134 (44%), Positives = 93/134 (69%), Gaps = 2/134 (1%) Frame = +2 Query: 11 RCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFK 190 + L++E + N S++S+L G + L+++ R I G ARGL YLH+D+ +IHRD K Sbjct: 597 KMLIYEYLENLSLDSYLFGKTR-RSKLNWNERFDITNGVARGLLYLHQDSRFRIIHRDLK 655 Query: 191 ASNVLLENDFTAKVADFGLAK--EASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVY 364 SN+LL+ + K++DFG+A+ E E E + +V+GT+GY++PEYAM G KSDV+ Sbjct: 656 VSNILLDKNMIPKISDFGMARIFERDE-TEANTMKVVGTYGYMSPEYAMYGIFSEKSDVF 714 Query: 365 SYGVVLLELLSGRK 406 S+GV++LE++SG+K Sbjct: 715 SFGVIVLEIVSGKK 728
>IRAK4_HUMAN (Q9NWZ3) Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1)| (IRAK-4) (NY-REN-64 antigen) Length = 460 Score = 114 bits (286), Expect = 8e-26 Identities = 63/135 (46%), Positives = 92/135 (68%), Gaps = 1/135 (0%) Frame = +2 Query: 14 CLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKA 193 CLV+ +PNGS+ L D PL + R KIA GAA G+ +LHE+ H IHRD K+ Sbjct: 259 CLVYVYMPNGSLLDRLSCLDGT-PPLSWHMRCKIAQGAANGINFLHEN---HHIHRDIKS 314 Query: 194 SNVLLENDFTAKVADFGLAKEASEGIEHIST-QVMGTFGYVAPEYAMTGHLLVKSDVYSY 370 +N+LL+ FTAK++DFGLA+ + + + + T +++GT Y+APE A+ G + KSD+YS+ Sbjct: 315 ANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPE-ALRGEITPKSDIYSF 373 Query: 371 GVVLLELLSGRKPVD 415 GVVLLE+++G VD Sbjct: 374 GVVLLEIITGLPAVD 388
>SIRK_ARATH (O64483) Senescence-induced receptor-like serine/threonine-protein| kinase precursor (FLG22-induced receptor-like kinase 1) Length = 876 Score = 110 bits (276), Expect = 1e-24 Identities = 59/133 (44%), Positives = 85/133 (63%), Gaps = 1/133 (0%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 L++E + N ++ +L G L ++ R+KI+L AA+GL YLH P ++HRD K + Sbjct: 644 LIYEYMANENLGDYLAGKRSFI--LSWEERLKISLDAAQGLEYLHNGCKPPIVHRDVKPT 701 Query: 197 NVLLENDFTAKVADFGLAKEAS-EGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYSYG 373 N+LL AK+ADFGL++ S EG IST V G+ GY+ PEY T + KSDVYS G Sbjct: 702 NILLNEKLQAKMADFGLSRSFSVEGSGQISTVVAGSIGYLDPEYYSTRQMNEKSDVYSLG 761 Query: 374 VVLLELLSGRKPV 412 VVLLE+++G+ + Sbjct: 762 VVLLEVITGQPAI 774
>IRAK1_HUMAN (P51617) Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1)| (IRAK-1) Length = 712 Score = 109 bits (272), Expect = 4e-24 Identities = 61/141 (43%), Positives = 85/141 (60%), Gaps = 8/141 (5%) Frame = +2 Query: 14 CLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKA 193 CLV+ +PNGS+E LH + PL + R+ I LG AR + +LH+D +P +IH D K+ Sbjct: 285 CLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLHQD-SPSLIHGDIKS 343 Query: 194 SNVLLENDFTAKVADFGLAK-------EASEGIEHISTQ-VMGTFGYVAPEYAMTGHLLV 349 SNVLL+ T K+ DFGLA+ S+ TQ V GT Y+ EY TG L V Sbjct: 344 SNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEEYIKTGRLAV 403 Query: 350 KSDVYSYGVVLLELLSGRKPV 412 +D +S+GVV+LE L+G++ V Sbjct: 404 DTDTFSFGVVVLETLAGQRAV 424
>IRAK1_MOUSE (Q62406) Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1)| (IRAK-1) (IRAK) (Pelle-like protein kinase) (mPLK) Length = 710 Score = 108 bits (271), Expect = 5e-24 Identities = 60/142 (42%), Positives = 84/142 (59%), Gaps = 9/142 (6%) Frame = +2 Query: 14 CLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKA 193 CLV+ +PNGS+E LH + PL + R+ I LG AR + +LH+D +P +IH D K+ Sbjct: 285 CLVYGFLPNGSLEDQLHLQTQACSPLSWPQRLDILLGTARAIQFLHQD-SPSLIHGDIKS 343 Query: 194 SNVLLENDFTAKVADFGLAK---------EASEGIEHISTQVMGTFGYVAPEYAMTGHLL 346 SNVLL+ K+ DFGLA+ S + ST V GT Y+ EY TG L Sbjct: 344 SNVLLDERLMPKLGDFGLARFSRFAGAKASQSSTVARTST-VRGTLAYLPEEYIKTGRLA 402 Query: 347 VKSDVYSYGVVLLELLSGRKPV 412 V +D +S+GVV+LE L+G++ V Sbjct: 403 VDTDTFSFGVVILETLAGQRAV 424
>KPRO_MAIZE (P17801) Putative receptor protein kinase ZmPK1 precursor (EC| 2.7.11.1) Length = 817 Score = 106 bits (265), Expect = 2e-23 Identities = 64/136 (47%), Positives = 85/136 (62%), Gaps = 4/136 (2%) Frame = +2 Query: 11 RCLVFELVPNGSVESHL--HGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRD 184 R LV E V NGS+ + L G + + LD++ R IALG A+GLAYLH + VIH D Sbjct: 602 RLLVSEYVENGSLANILFSEGGNIL---LDWEGRFNIALGVAKGLAYLHHECLEWVIHCD 658 Query: 185 FKASNVLLENDFTAKVADFGLAKEASEG--IEHISTQVMGTFGYVAPEYAMTGHLLVKSD 358 K N+LL+ F K+ DFGL K + G +++S V GT GY+APE+ + + K D Sbjct: 659 VKPENILLDQAFEPKITDFGLVKLLNRGGSTQNVS-HVRGTLGYIAPEWVSSLPITAKVD 717 Query: 359 VYSYGVVLLELLSGRK 406 VYSYGVVLLELL+G + Sbjct: 718 VYSYGVVLLELLTGTR 733
>KPEL_DROME (Q05652) Probable serine/threonine-protein kinase pelle (EC| 2.7.11.1) Length = 501 Score = 94.4 bits (233), Expect = 1e-19 Identities = 51/138 (36%), Positives = 79/138 (57%), Gaps = 4/138 (2%) Frame = +2 Query: 14 CLVFELVPNGSVESHL--HGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDF 187 CLV++L+ GS+E+ L H + L + R I+LG ARG+ +LH +IH D Sbjct: 288 CLVYQLMKGGSLEARLRAHKAQNPLPALTWQQRFSISLGTARGIYFLHTARGTPLIHGDI 347 Query: 188 KASNVLLENDFTAKVADFGLAKEASEGIEHI--STQVMGTFGYVAPEYAMTGHLLVKSDV 361 K +N+LL+ K+ DFGL +E + ++ + +V GT Y+ PE+ L DV Sbjct: 348 KPANILLDQCLQPKIGDFGLVREGPKSLDAVVEVNKVFGTKIYLPPEFRNFRQLSTGVDV 407 Query: 362 YSYGVVLLELLSGRKPVD 415 YS+G+VLLE+ +GR+ D Sbjct: 408 YSFGIVLLEVFTGRQVTD 425
>TMKL1_ARATH (P33543) Putative kinase-like protein TMKL1 precursor| Length = 674 Score = 93.2 bits (230), Expect = 3e-19 Identities = 51/136 (37%), Positives = 79/136 (58%) Frame = +2 Query: 2 RRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHR 181 R + L+++ +PN S+ LH S L++ R KIALG ARGLAYLH +IH Sbjct: 440 RGEKLLIYDYLPNISLHDLLHESKPRKPALNWARRHKIALGIARGLAYLHTGQEVPIIHG 499 Query: 182 DFKASNVLLENDFTAKVADFGLAKEASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDV 361 + ++ NVL+++ F A++ +FGL K + + + GY APE +SDV Sbjct: 500 NIRSKNVLVDDFFFARLTEFGLDKIMVQAVADEIVSQAKSDGYKAPELHKMKKCNPRSDV 559 Query: 362 YSYGVVLLELLSGRKP 409 Y++G++LLE+L G+KP Sbjct: 560 YAFGILLLEILMGKKP 575
>RIPK2_MOUSE (P58801) Receptor-interacting serine/threonine-protein kinase 2 (EC| 2.7.11.1) Length = 539 Score = 85.9 bits (211), Expect = 4e-17 Identities = 54/145 (37%), Positives = 81/145 (55%), Gaps = 8/145 (5%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 +V E +PNGS+ LH + Y + + R +I A G+ YLH + NP ++H D K Sbjct: 93 IVTEYMPNGSLNELLHRKTE-YPDIAWPLRFRILHEIALGVNYLH-NMNPPLLHHDLKTQ 150 Query: 197 NVLLENDFTAKVADFGLAK----EASEGIEHISTQVMGTFGYVAPEYAMTG---HLLVKS 355 N+LL+N+F K+ADFGL+K S+ + S GT Y+ PE G VK Sbjct: 151 NILLDNEFHVKIADFGLSKWRMMSLSQSRSYKSAPEGGTIIYMPPENYEPGQKSRASVKH 210 Query: 356 DVYSYGVVLLELLSGRKPV-DMTQP 427 D+YSY V++ E+LS ++P ++T P Sbjct: 211 DIYSYAVIMWEVLSRKQPFEEVTNP 235
>YR831_MIMIV (Q7T6Y2) Putative serine/threonine-protein kinase/receptor R831| precursor (EC 2.7.11.1) Length = 1624 Score = 83.2 bits (204), Expect = 3e-16 Identities = 46/132 (34%), Positives = 76/132 (57%) Frame = +2 Query: 14 CLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKA 193 C+V E + G++ L D + F ++K+ GAA G+ YLH +NP ++HRD K Sbjct: 1435 CIVTEYMRMGNLRDVLKNPDI---KITFANKLKLLYGAAMGIDYLHS-SNPMIVHRDIKP 1490 Query: 194 SNVLLENDFTAKVADFGLAKEASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYSYG 373 +N+L++ F K+ADFG A+ ++ + GT + APE K+DV+S+G Sbjct: 1491 ANILVDEHFNVKIADFGFARIKE---DNTTMTRCGTPCWTAPEVIRGEKYCEKADVFSFG 1547 Query: 374 VVLLELLSGRKP 409 VV+ E+L+G++P Sbjct: 1548 VVMWEVLTGKEP 1559 Score = 76.3 bits (186), Expect = 3e-14 Identities = 45/142 (31%), Positives = 82/142 (57%), Gaps = 3/142 (2%) Frame = +2 Query: 14 CLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKA 193 C+V E + GS+ L +++ + + ++K+A A++G+ +LH ++HRD K+ Sbjct: 857 CIVMEFMSLGSLYDLL--GNELIPEIPYALKIKMAYQASKGMHFLHSSG---IVHRDLKS 911 Query: 194 SNVLLENDFTAKVADFGLAKEASE-GIEHISTQVMGTFGYVAPEYA--MTGHLLVKSDVY 364 N+LL++ + KV+DFGL K SE + + ++GT ++APE T + +DVY Sbjct: 912 LNLLLDSKWNVKVSDFGLTKVKSELDKKKTNDNIIGTIHWIAPEILNDSTEVDYILADVY 971 Query: 365 SYGVVLLELLSGRKPVDMTQPS 430 S+G++L ELL+ +P P+ Sbjct: 972 SFGIILWELLTREQPYKGMTPA 993
>RIPK2_HUMAN (O43353) Receptor-interacting serine/threonine-protein kinase 2 (EC| 2.7.11.1) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (CARD-containing interleukin-1 beta-converting enzyme-associated kinase) (CARD-containi Length = 540 Score = 82.0 bits (201), Expect = 6e-16 Identities = 53/145 (36%), Positives = 78/145 (53%), Gaps = 8/145 (5%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 +V E +PNGS+ LH + Y + + R +I A G+ YLH + P ++H D K Sbjct: 93 IVTEYMPNGSLNELLHRKTE-YPDVAWPLRFRILHEIALGVNYLH-NMTPPLLHHDLKTQ 150 Query: 197 NVLLENDFTAKVADFGLAK----EASEGIEHISTQVMGTFGYVAPEYAMTG---HLLVKS 355 N+LL+N+F K+ADFGL+K S+ S GT Y+ PE G +K Sbjct: 151 NILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKH 210 Query: 356 DVYSYGVVLLELLSGRKPV-DMTQP 427 D+YSY V+ E+LS ++P D+T P Sbjct: 211 DIYSYAVITWEVLSRKQPFEDVTNP 235
>SRK1_SPOLA (P42686) Tyrosine-protein kinase isoform SRK1 (EC 2.7.10.2)| Length = 505 Score = 82.0 bits (201), Expect = 6e-16 Identities = 55/145 (37%), Positives = 77/145 (53%), Gaps = 2/145 (1%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 +V EL+ GS+ +L G D G L + + +A A G++YL + + IHRD A Sbjct: 310 IVTELMKYGSLLEYLRGED---GVLKIEQLVDVAAQVASGMSYLEQQ---NYIHRDLAAR 363 Query: 197 NVLLENDFTAKVADFGLAKEASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYSYGV 376 N+L+ KVADFGLA+ E I T + APE AM +KSDV+S+GV Sbjct: 364 NILVGEHGICKVADFGLARVIDEEIYEAHTGAKFPIKWTAPEAAMYNRFTIKSDVWSFGV 423 Query: 377 VLLELLS-GRKPV-DMTQPSGSENL 445 VL E+++ GR P MT P E + Sbjct: 424 VLYEIITYGRFPYPGMTNPEVLEKI 448
>M3LK7_DROME (P83104) Putative mitogen-activated protein kinase kinase kinase| 7-like (EC 2.7.11.25) Length = 393 Score = 79.3 bits (194), Expect = 4e-15 Identities = 50/142 (35%), Positives = 75/142 (52%), Gaps = 1/142 (0%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 L+ E + GS+ ++L+G DK + ++ AL A+ LAYLH P ++HRD K Sbjct: 81 LLMEYLEEGSLHNYLYGDDK--WEYTVEQAVRWALQCAKALAYLHSLDRP-IVHRDIKPQ 137 Query: 197 NVLLENDFT-AKVADFGLAKEASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYSYG 373 N+LL N K+ DFGLA + S T + GT Y+APE K DVYS+G Sbjct: 138 NMLLYNQHEDLKICDFGLATDMSNN----KTDMQGTLRYMAPEAIKHLKYTAKCDVYSFG 193 Query: 374 VVLLELLSGRKPVDMTQPSGSE 439 ++L EL++ + P + S+ Sbjct: 194 IMLWELMTRQLPYSHLENPNSQ 215
>CTR1_ARATH (Q05609) Serine/threonine-protein kinase CTR1 (EC 2.7.11.1)| Length = 821 Score = 79.0 bits (193), Expect = 5e-15 Identities = 52/139 (37%), Positives = 79/139 (56%), Gaps = 1/139 (0%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 +V E + GS+ LH S LD R+ +A A+G+ YLH + NP ++HRD K+ Sbjct: 623 IVTEYLSRGSLYRLLHKSGA-REQLDERRRLSMAYDVAKGMNYLH-NRNPPIVHRDLKSP 680 Query: 197 NVLLENDFTAKVADFGLAK-EASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYSYG 373 N+L++ +T KV DFGL++ +AS + S GT ++APE KSDVYS+G Sbjct: 681 NLLVDKKYTVKVCDFGLSRLKASTFLS--SKSAAGTPEWMAPEVLRDEPSNEKSDVYSFG 738 Query: 374 VVLLELLSGRKPVDMTQPS 430 V+L EL + ++P P+ Sbjct: 739 VILWELATLQQPWGNLNPA 757
>TNI3K_RAT (Q7TQP6) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 834 Score = 79.0 bits (193), Expect = 5e-15 Identities = 49/141 (34%), Positives = 77/141 (54%), Gaps = 1/141 (0%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 +V + + GS+ S LH +I LD +++ IA+ A+G+ YLH P +IHRD + Sbjct: 536 IVTQYISGGSLFSLLHEQKRI---LDLQSKLIIAVDVAKGMEYLHSLTQP-IIHRDLNSH 591 Query: 197 NVLLENDFTAKVADFGLAKEASEGIEHISTQVMGTFGYVAPE-YAMTGHLLVKSDVYSYG 373 N+LL D A VADFG ++ E T+ G ++APE + +K+DV+SY Sbjct: 592 NILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNLRWMAPEVFTQCTRYTIKADVFSYS 651 Query: 374 VVLLELLSGRKPVDMTQPSGS 436 + L ELL+G P +P+ + Sbjct: 652 LCLWELLTGEIPFAHLKPAAA 672
>TNI3K_HUMAN (Q59H18) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 936 Score = 78.2 bits (191), Expect = 9e-15 Identities = 48/141 (34%), Positives = 77/141 (54%), Gaps = 1/141 (0%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 +V + + GS+ S LH +I LD +++ IA+ A+G+ YLH P +IHRD + Sbjct: 638 IVTQYISGGSLFSLLHEQKRI---LDLQSKLIIAVDVAKGMEYLHNLTQP-IIHRDLNSH 693 Query: 197 NVLLENDFTAKVADFGLAKEASEGIEHISTQVMGTFGYVAPE-YAMTGHLLVKSDVYSYG 373 N+LL D A VADFG ++ E T+ G ++APE + +K+DV+SY Sbjct: 694 NILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNLRWMAPEVFTQCTRYTIKADVFSYA 753 Query: 374 VVLLELLSGRKPVDMTQPSGS 436 + L E+L+G P +P+ + Sbjct: 754 LCLWEILTGEIPFAHLKPAAA 774
>TNI3K_MOUSE (Q5GIG6) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 833 Score = 77.8 bits (190), Expect = 1e-14 Identities = 49/141 (34%), Positives = 76/141 (53%), Gaps = 1/141 (0%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 +V + + GS+ S LH +I LD +++ IA+ A+G+ YLH P +IHRD + Sbjct: 535 IVTQYISGGSLFSLLHEQKRI---LDLQSKLIIAVDVAKGMEYLHSLTQP-IIHRDLNSH 590 Query: 197 NVLLENDFTAKVADFGLAKEASEGIEHISTQVMGTFGYVAPE-YAMTGHLLVKSDVYSYG 373 N+LL D A VADFG ++ E T+ G ++APE + +K+DV+SY Sbjct: 591 NILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNLRWMAPEVFTQCTRYTIKADVFSYA 650 Query: 374 VVLLELLSGRKPVDMTQPSGS 436 + L ELL G P +P+ + Sbjct: 651 LCLWELLIGEIPFAHLKPAAA 671
>PKN6_MYXXA (P54738) Serine/threonine-protein kinase pkn6 (EC 2.7.11.1)| Length = 710 Score = 77.8 bits (190), Expect = 1e-14 Identities = 43/110 (39%), Positives = 59/110 (53%), Gaps = 6/110 (5%) Frame = +2 Query: 110 KIALGAARGLAYLHEDANPH------VIHRDFKASNVLLENDFTAKVADFGLAKEASEGI 271 K+ AA GLAY HE + +IHRD N+L+ KV DFG+AK A +G Sbjct: 113 KVVAAAAEGLAYAHEFRDVETGEPLGLIHRDVSPDNILVSRQGAVKVVDFGIAKVAGQGH 172 Query: 272 EHISTQVMGTFGYVAPEYAMTGHLLVKSDVYSYGVVLLELLSGRKPVDMT 421 ++ V G Y+ PE + + DVY+ GVVL ELL+G++P D T Sbjct: 173 RTLTGVVKGKVAYMPPEQLQAKAMDRRVDVYALGVVLYELLTGKRPFDAT 222
>HT1_ARATH (Q2MHE4) Serine/threonine-protein kinase HT1 (EC 2.7.11.1) (High| leaf temperature protein 1) Length = 390 Score = 77.4 bits (189), Expect = 1e-14 Identities = 47/138 (34%), Positives = 76/138 (55%) Frame = +2 Query: 14 CLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKA 193 C++ E + G++ +L+ + L +T +++AL +RG+ YLH VIHRD K+ Sbjct: 161 CIITEYMSQGNLRMYLNKKEPY--SLSIETVLRLALDISRGMEYLHSQG---VIHRDLKS 215 Query: 194 SNVLLENDFTAKVADFGLAKEASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYSYG 373 +N+LL ++ KVADFG + ++ E + MGT+ ++APE K DVYS+G Sbjct: 216 NNLLLNDEMRVKVADFGTSCLETQCRE--AKGNMGTYRWMAPEMIKEKPYTRKVDVYSFG 273 Query: 374 VVLLELLSGRKPVDMTQP 427 +VL EL + P P Sbjct: 274 IVLWELTTALLPFQGMTP 291
>PKN2_CLOAB (Q97IC2) Probable serine/threonine protein kinase CAC1728 (EC| 2.7.11.1) Length = 657 Score = 77.0 bits (188), Expect = 2e-14 Identities = 37/115 (32%), Positives = 69/115 (60%) Frame = +2 Query: 83 GPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKASNVLLENDFTAKVADFGLAKEAS 262 G ++F+ + A A+ L + H++ ++HRD K N+++ +D KV DFG+AK ++ Sbjct: 103 GKIEFNKIIDYATQIAKALNFAHKNG---IVHRDIKPHNIMVTDDDIIKVTDFGIAKASN 159 Query: 263 EGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYSYGVVLLELLSGRKPVDMTQP 427 E + +V+G+ Y++PE A + ++D+YS+G+VL E+ +G+ P D P Sbjct: 160 ESTITTTNKVVGSAHYLSPEQAQGIPVDCRTDIYSFGIVLYEMATGKVPYDADTP 214
>M3KSL_DROME (Q95UN8) Mitogen-activated protein kinase kinase kinase (EC| 2.7.11.25) (Mixed lineage kinase) (dMLK) (Protein slipper) Length = 1161 Score = 76.6 bits (187), Expect = 3e-14 Identities = 53/143 (37%), Positives = 72/143 (50%), Gaps = 11/143 (7%) Frame = +2 Query: 14 CLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKA 193 CLV E GS+ L G + D + A+ ARG+ YLH +A +IHRD K+ Sbjct: 214 CLVMEYARGGSLNRILAGK------IPPDVLVNWAIQIARGMNYLHNEAPMSIIHRDLKS 267 Query: 194 SNVLLENDF--------TAKVADFGLAKEASEGIEHISTQVM---GTFGYVAPEYAMTGH 340 SNVL+ T K+ DFGLA+E +TQ M GT+ ++ PE Sbjct: 268 SNVLIYEAIEGNHLQQKTLKITDFGLAREM------YNTQRMSAAGTYAWMPPEVISVST 321 Query: 341 LLVKSDVYSYGVVLLELLSGRKP 409 SDV+SYGV+L EL++G P Sbjct: 322 YSKFSDVWSYGVLLWELITGETP 344
>PKN1_THETN (Q8R9T6) Probable serine/threonine-protein kinase Sps1 (EC| 2.7.11.1) Length = 625 Score = 76.3 bits (186), Expect = 3e-14 Identities = 40/115 (34%), Positives = 66/115 (57%) Frame = +2 Query: 83 GPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKASNVLLENDFTAKVADFGLAKEAS 262 GPL+ ++IA R L + H++ +IHRD K N+L+ ++ KV DFG+A+ A+ Sbjct: 104 GPLEVKRAVEIASQVCRALDHAHKNK---IIHRDIKPQNILVTDEDVVKVTDFGIARAAN 160 Query: 263 EGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYSYGVVLLELLSGRKPVDMTQP 427 + V+GT Y +PE A + ++D+YS G+VL E+L+G+ P + P Sbjct: 161 GATITYTGDVIGTAYYFSPEQAKGSIVDERTDIYSLGIVLFEMLTGKVPFEGDSP 215
>M3KL4_HUMAN (Q5TCX8) Mitogen-activated protein kinase kinase kinase (EC| 2.7.11.25) (Mixed lineage kinase 4) Length = 1036 Score = 75.5 bits (184), Expect = 6e-14 Identities = 54/152 (35%), Positives = 80/152 (52%), Gaps = 20/152 (13%) Frame = +2 Query: 14 CLVFELVPNGSVESHLHGSDKIYGPLDFDTR----------MKIALGAARGLAYLHEDAN 163 CLV E G++ L ++ P R + A+ ARG+ YLHE+A Sbjct: 197 CLVLEFARGGALNRALAAANAAPDPRAPGPRRARRIPPHVLVNWAVQIARGMLYLHEEAF 256 Query: 164 PHVIHRDFKASNVLL----END----FTAKVADFGLAKEASEGIEHISTQV--MGTFGYV 313 ++HRD K+SN+LL E+D T K+ DFGLA+E H +T++ GT+ ++ Sbjct: 257 VPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLARE-----WHRTTKMSTAGTYAWM 311 Query: 314 APEYAMTGHLLVKSDVYSYGVVLLELLSGRKP 409 APE + SD++SYGV+L ELL+G P Sbjct: 312 APEVIKSSLFSKGSDIWSYGVLLWELLTGEVP 343
>M3K9_HUMAN (P80192) Mitogen-activated protein kinase kinase kinase 9 (EC| 2.7.11.25) (Mixed lineage kinase 1) Length = 1104 Score = 75.5 bits (184), Expect = 6e-14 Identities = 53/142 (37%), Positives = 76/142 (53%), Gaps = 10/142 (7%) Frame = +2 Query: 14 CLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKA 193 CLV E G + L G + D + A+ ARG+ YLH++A +IHRD K+ Sbjct: 217 CLVMEFARGGPLNRVLSGKR-----IPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKS 271 Query: 194 SNVLL----EN----DFTAKVADFGLAKEASEGIEHISTQV--MGTFGYVAPEYAMTGHL 343 SN+L+ EN + K+ DFGLA+E H +T++ GT+ ++APE Sbjct: 272 SNILILQKVENGDLSNKILKITDFGLARE-----WHRTTKMSAAGTYAWMAPEVIRASMF 326 Query: 344 LVKSDVYSYGVVLLELLSGRKP 409 SDV+SYGV+L ELL+G P Sbjct: 327 SKGSDVWSYGVLLWELLTGEVP 348
>KYK1_DICDI (P18160) Non-receptor tyrosine kinase spore lysis A (EC 2.7.10.2)| (Tyrosine-protein kinase 1) Length = 1584 Score = 75.5 bits (184), Expect = 6e-14 Identities = 51/151 (33%), Positives = 77/151 (50%), Gaps = 13/151 (8%) Frame = +2 Query: 14 CLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKA 193 C+V E + GS+ L + + R+K+AL A+G+ YLH P ++HRD + Sbjct: 1363 CIVTEWMGGGSLRQFLTDHFNLLEQ-NPHIRLKLALDIAKGMNYLH-GWTPPILHRDLSS 1420 Query: 194 SNVLLEN-------------DFTAKVADFGLAKEASEGIEHISTQVMGTFGYVAPEYAMT 334 N+LL++ D K++DFGL++ E + TQ +G Y+APE Sbjct: 1421 RNILLDHNIDPKNPVVSSRQDIKCKISDFGLSRLKKEQASQM-TQSVGCIPYMAPEVFKG 1479 Query: 335 GHLLVKSDVYSYGVVLLELLSGRKPVDMTQP 427 KSDVYSYG+VL ELL+ +P +P Sbjct: 1480 DSNSEKSDVYSYGMVLFELLTSDEPQQDMKP 1510
>BCK1_YEAST (Q01389) Serine/threonine-protein kinase BCK1/SLK1/SSP31 (EC| 2.7.11.1) Length = 1478 Score = 75.1 bits (183), Expect = 7e-14 Identities = 43/132 (32%), Positives = 72/132 (54%), Gaps = 1/132 (0%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 L E V GSV S + ++YG D + +GLAYLH ++HRD KA Sbjct: 1255 LFLEYVAGGSVGSLI----RMYGRFDEPLIKHLTTQVLKGLAYLHSKG---ILHRDMKAD 1307 Query: 197 NVLLENDFTAKVADFGLAKEASEGIEHISTQVMGTFGYVAPEYAMTGH-LLVKSDVYSYG 373 N+LL+ D K++DFG+++++ + + + GT ++APE T K D++S G Sbjct: 1308 NLLLDQDGICKISDFGISRKSKDIYSNSDMTMRGTVFWMAPEMVDTKQGYSAKVDIWSLG 1367 Query: 374 VVLLELLSGRKP 409 ++LE+ +G++P Sbjct: 1368 CIVLEMFAGKRP 1379
>PKN5_MYXXA (P54737) Serine/threonine-protein kinase pkn5 (EC 2.7.11.1)| Length = 380 Score = 74.3 bits (181), Expect = 1e-13 Identities = 44/110 (40%), Positives = 67/110 (60%), Gaps = 2/110 (1%) Frame = +2 Query: 104 RMKIA-LGAARGLAYLHEDANPHVIHRDFKASNVLLENDFTAKVADFGLAKE-ASEGIEH 277 R+K A L LAY+H ++HRD K SN+++++D ++ DFGLAK A + Sbjct: 220 RLKDAMLQICEALAYIHGHG---LVHRDLKPSNIMVDDDRQVRLMDFGLAKFLADDAAIT 276 Query: 278 ISTQVMGTFGYVAPEYAMTGHLLVKSDVYSYGVVLLELLSGRKPVDMTQP 427 + +++GT+ Y+APE + L ++D+YS GV+L ELLSGR P D P Sbjct: 277 EAGKLVGTYRYMAPEQILGEPLDGRADLYSLGVILYELLSGRPPFDAKTP 326
>PKN2_BACSU (O34507) Probable serine/threonine-protein kinase yloP (EC| 2.7.11.1) Length = 648 Score = 74.3 bits (181), Expect = 1e-13 Identities = 43/133 (32%), Positives = 71/133 (53%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 +V E V +++ ++ + GPL + I +A+ H++ ++HRD K Sbjct: 86 IVMEYVEGMTLKEYITAN----GPLHPKEALNIMEQIVSAIAHAHQN---QIVHRDIKPH 138 Query: 197 NVLLENDFTAKVADFGLAKEASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYSYGV 376 N+L+++ KV DFG+A S + V+G+ Y++PE A G KSD+Y+ G+ Sbjct: 139 NILIDHMGNIKVTDFGIATALSSTTITHTNSVLGSVHYLSPEQARGGLATKKSDIYALGI 198 Query: 377 VLLELLSGRKPVD 415 VL ELL+GR P D Sbjct: 199 VLFELLTGRIPFD 211
>M3K7_MOUSE (Q62073) Mitogen-activated protein kinase kinase kinase 7 (EC| 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1) Length = 579 Score = 73.9 bits (180), Expect = 2e-13 Identities = 50/138 (36%), Positives = 74/138 (53%), Gaps = 4/138 (2%) Frame = +2 Query: 14 CLVFELVPNGSVESHLHGSDKIYGPLDFDTR---MKIALGAARGLAYLHEDANPHVIHRD 184 CLV E GS+ + LHG++ PL + T M L ++G+AYLH +IHRD Sbjct: 101 CLVMEYAEGGSLYNVLHGAE----PLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRD 156 Query: 185 FKASNVLLENDFTA-KVADFGLAKEASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDV 361 K N+LL T K+ DFG A + I+ T G+ ++APE + K DV Sbjct: 157 LKPPNLLLVAGGTVLKICDFGTACD----IQTHMTNNKGSAAWMAPEVFEGSNYSEKCDV 212 Query: 362 YSYGVVLLELLSGRKPVD 415 +S+G++L E+++ RKP D Sbjct: 213 FSWGIILWEVITRRKPFD 230
>M3K7_HUMAN (O43318) Mitogen-activated protein kinase kinase kinase 7 (EC| 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1) Length = 606 Score = 73.9 bits (180), Expect = 2e-13 Identities = 50/138 (36%), Positives = 74/138 (53%), Gaps = 4/138 (2%) Frame = +2 Query: 14 CLVFELVPNGSVESHLHGSDKIYGPLDFDTR---MKIALGAARGLAYLHEDANPHVIHRD 184 CLV E GS+ + LHG++ PL + T M L ++G+AYLH +IHRD Sbjct: 101 CLVMEYAEGGSLYNVLHGAE----PLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRD 156 Query: 185 FKASNVLLENDFTA-KVADFGLAKEASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDV 361 K N+LL T K+ DFG A + I+ T G+ ++APE + K DV Sbjct: 157 LKPPNLLLVAGGTVLKICDFGTACD----IQTHMTNNKGSAAWMAPEVFEGSNYSEKCDV 212 Query: 362 YSYGVVLLELLSGRKPVD 415 +S+G++L E+++ RKP D Sbjct: 213 FSWGIILWEVITRRKPFD 230
>FUZ7_USTMA (Q99078) Dual specificity protein kinase FUZ7 (EC 2.7.12.2)| Length = 435 Score = 73.9 bits (180), Expect = 2e-13 Identities = 46/132 (34%), Positives = 71/132 (53%) Frame = +2 Query: 14 CLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKA 193 C+ E + S++ G K YGP+ + KIA+ + GL YL++ +IHRD K Sbjct: 181 CMCMEFMQKDSLD----GIYKKYGPISPEICGKIAVAVSHGLTYLYDVHR--IIHRDVKP 234 Query: 194 SNVLLENDFTAKVADFGLAKEASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYSYG 373 SN+L+ K+ DFG++ E I I+ +GT Y++PE VKSDV+S G Sbjct: 235 SNILVNGAGQIKICDFGVSGEL---INSIADTFVGTSTYMSPERIQGDQYSVKSDVWSLG 291 Query: 374 VVLLELLSGRKP 409 V ++++ GR P Sbjct: 292 VSIIDVALGRFP 303
>PKNB_LACLA (Q9CEF5) Probable serine/threonine-protein kinase pknB (EC| 2.7.11.1) Length = 627 Score = 73.9 bits (180), Expect = 2e-13 Identities = 43/133 (32%), Positives = 71/133 (53%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 +V E V +++ +++ + PL D ++I + H +IHRD K Sbjct: 88 IVMEFVDGMTLKQYINQN----APLANDEAIEIITEILSAMDMAHSHG---IIHRDLKPQ 140 Query: 197 NVLLENDFTAKVADFGLAKEASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYSYGV 376 NVL+ + T KV DFG+AK SE + + G+ Y++PE A + V+SD+Y+ G+ Sbjct: 141 NVLVSSSGTVKVTDFGIAKALSETSLTQTNTMFGSVHYLSPEQARGSNATVQSDIYAIGI 200 Query: 377 VLLELLSGRKPVD 415 +L ELL+G+ P D Sbjct: 201 ILFELLTGQIPFD 213
>PKSC_STRCO (Q9S2C0) Serine/threonine protein kinase pksC (EC 2.7.11.1)| Length = 556 Score = 73.2 bits (178), Expect = 3e-13 Identities = 45/142 (31%), Positives = 71/142 (50%), Gaps = 2/142 (1%) Frame = +2 Query: 8 TRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDF 187 T +V E V + S L + G + D +KI L HE ++HRD Sbjct: 96 TPYIVMEYVEGRPLGSVLDEDVRQQGAMPADKALKITADVLAALEISHEMG---LVHRDI 152 Query: 188 KASNVLLENDFTAKVADFGLAKEASEGIEHIST--QVMGTFGYVAPEYAMTGHLLVKSDV 361 K NV++ KV DFG+A+ G+ ++ V+GT Y++PE A+ + +SD+ Sbjct: 153 KPGNVMMTKRGVVKVMDFGIARAMQSGVTSMTQTGMVVGTPQYLSPEQALGRGVDARSDL 212 Query: 362 YSYGVVLLELLSGRKPVDMTQP 427 YS G++L +L++GR P D P Sbjct: 213 YSVGIMLFQLVTGRLPFDADSP 234
>TYK2_HUMAN (P29597) Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2)| Length = 1187 Score = 73.2 bits (178), Expect = 3e-13 Identities = 52/130 (40%), Positives = 64/130 (49%), Gaps = 3/130 (2%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 LV E VP GS+ +L + + A G+AYLH H IHRD A Sbjct: 976 LVMEYVPLGSLRDYLPRHS-----IGLAQLLLFAQQICEGMAYLHAQ---HYIHRDLAAR 1027 Query: 197 NVLLENDFTAKVADFGLAKEASEGIEHISTQVMG---TFGYVAPEYAMTGHLLVKSDVYS 367 NVLL+ND K+ DFGLAK EG E+ + G F Y APE SDV+S Sbjct: 1028 NVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWY-APECLKEYKFYYASDVWS 1086 Query: 368 YGVVLLELLS 397 +GV L ELL+ Sbjct: 1087 FGVTLYELLT 1096
>IRAK3_MOUSE (Q8K4B2) Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1)| (IRAK-3) (IL-1 receptor-associated kinase M) (IRAK-M) Length = 609 Score = 73.2 bits (178), Expect = 3e-13 Identities = 45/139 (32%), Positives = 75/139 (53%), Gaps = 6/139 (4%) Frame = +2 Query: 14 CLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKA 193 CLV+ + NG++ L ++ PL + R+ + +G A+ + YLH VI + + Sbjct: 251 CLVYPYMSNGTLFDRLQCTNGTT-PLSWHVRISVLIGIAKAIQYLHNTQPCAVICGNVSS 309 Query: 194 SNVLLENDFTAKVADFGLAKEASEGIEHISTQVMGTFG------YVAPEYAMTGHLLVKS 355 +N+LL++ K+ DF A +E S+ + T G Y+ EY G L VK+ Sbjct: 310 ANILLDDQLQPKLTDFAAA-HFRPNLEQQSSTINMTGGGRKHLWYMPEEYIRQGRLSVKT 368 Query: 356 DVYSYGVVLLELLSGRKPV 412 DVYS+G+V++E+L+G K V Sbjct: 369 DVYSFGIVIMEVLTGCKVV 387
>M3K10_HUMAN (Q02779) Mitogen-activated protein kinase kinase kinase 10 (EC| 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST) Length = 954 Score = 72.8 bits (177), Expect = 4e-13 Identities = 52/142 (36%), Positives = 74/142 (52%), Gaps = 10/142 (7%) Frame = +2 Query: 14 CLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKA 193 CLV E G++ L G + + A+ ARG+ YLH DA +IHRD K+ Sbjct: 171 CLVMEYARGGALSRVLAGRR-----VPPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKS 225 Query: 194 SNVL----LEN----DFTAKVADFGLAKEASEGIEHISTQV--MGTFGYVAPEYAMTGHL 343 N+L +EN D K+ DFGLA+E H +T++ GT+ ++APE Sbjct: 226 INILILEAIENHNLADTVLKITDFGLARE-----WHKTTKMSAAGTYAWMAPEVIRLSLF 280 Query: 344 LVKSDVYSYGVVLLELLSGRKP 409 SDV+S+GV+L ELL+G P Sbjct: 281 SKSSDVWSFGVLLWELLTGEVP 302
>MLTK_HUMAN (Q9NYL2) Mitogen-activated protein kinase kinase kinase MLT (EC| 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper-and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase Length = 800 Score = 72.8 bits (177), Expect = 4e-13 Identities = 47/131 (35%), Positives = 70/131 (53%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 +V E GS+ +++ + +D D M A A+G+ YLH +A VIHRD K+ Sbjct: 80 IVTEYASLGSLYDYINSNRS--EEMDMDHIMTWATDVAKGMHYLHMEAPVKVIHRDLKSR 137 Query: 197 NVLLENDFTAKVADFGLAKEASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYSYGV 376 NV++ D K+ DFG A H+S ++GTF ++APE + + D YSYGV Sbjct: 138 NVVIAADGVLKICDFG-ASRFHNHTTHMS--LVGTFPWMAPEVIQSLPVSETCDTYSYGV 194 Query: 377 VLLELLSGRKP 409 VL E+L+ P Sbjct: 195 VLWEMLTREVP 205
>M3K11_HUMAN (Q16584) Mitogen-activated protein kinase kinase kinase 11 (EC| 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline-rich kinase) Length = 847 Score = 72.4 bits (176), Expect = 5e-13 Identities = 54/142 (38%), Positives = 75/142 (52%), Gaps = 10/142 (7%) Frame = +2 Query: 14 CLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKA 193 CLV E G + L G + + A+ ARG+ YLH +A VIHRD K+ Sbjct: 190 CLVMEYAAGGPLSRALAGRR-----VPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKS 244 Query: 194 SNVLL----ENDF----TAKVADFGLAKEASEGIEHISTQVM--GTFGYVAPEYAMTGHL 343 +N+LL E+D T K+ DFGLA+E H +TQ+ GT+ ++APE Sbjct: 245 NNILLLQPIESDDMEHKTLKITDFGLAREW-----HKTTQMSAAGTYAWMAPEVIKASTF 299 Query: 344 LVKSDVYSYGVVLLELLSGRKP 409 SDV+S+GV+L ELL+G P Sbjct: 300 SKGSDVWSFGVLLWELLTGEVP 321
>TYK2_MOUSE (Q9R117) Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2)| Length = 1180 Score = 72.0 bits (175), Expect = 6e-13 Identities = 53/130 (40%), Positives = 64/130 (49%), Gaps = 3/130 (2%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 LV E VP GS+ +L L + A G+AYLH H IHRD A Sbjct: 969 LVMEYVPLGSLRDYLPRHCVGLAQL-----LLFAQQICEGMAYLHAQ---HYIHRDLAAR 1020 Query: 197 NVLLENDFTAKVADFGLAKEASEGIEHISTQVMG---TFGYVAPEYAMTGHLLVKSDVYS 367 NVLL+ND K+ DFGLAK EG E+ + G F Y APE SDV+S Sbjct: 1021 NVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWY-APECLKECKFYYASDVWS 1079 Query: 368 YGVVLLELLS 397 +GV L ELL+ Sbjct: 1080 FGVTLYELLT 1089
>MEK2_CAEEL (Q10664) Dual specificity mitogen-activated protein kinase kinase| mek-2 (EC 2.7.12.2) (MAP kinase kinase mek-2) Length = 387 Score = 72.0 bits (175), Expect = 6e-13 Identities = 37/101 (36%), Positives = 62/101 (61%) Frame = +2 Query: 110 KIALGAARGLAYLHEDANPHVIHRDFKASNVLLENDFTAKVADFGLAKEASEGIEHISTQ 289 +I++ RGL YL ++ ++HRD K SN+L+ ++ K+ DFG++ I+ ++ Sbjct: 173 RISVAVVRGLTYLKDEIK--ILHRDVKPSNMLVNSNGEIKLCDFGVSGML---IDSMANS 227 Query: 290 VMGTFGYVAPEYAMTGHLLVKSDVYSYGVVLLELLSGRKPV 412 +GT Y+APE H + SD++S+G+ L+ELL GR PV Sbjct: 228 FVGTRSYMAPERLTGSHYTISSDIWSFGLSLVELLIGRYPV 268
>MKK1_YEAST (P32490) MAP kinase kinase MKK1/SSP32 (EC 2.7.12.2)| Length = 508 Score = 72.0 bits (175), Expect = 6e-13 Identities = 42/100 (42%), Positives = 58/100 (58%) Frame = +2 Query: 110 KIALGAARGLAYLHEDANPHVIHRDFKASNVLLENDFTAKVADFGLAKEASEGIEHISTQ 289 KIA RGL+YLHE VIHRD K N+LL + K+ DFG++ EA + ++T Sbjct: 328 KIAEAVLRGLSYLHEKK---VIHRDIKPQNILLNENGQVKLCDFGVSGEA---VNSLATT 381 Query: 290 VMGTFGYVAPEYAMTGHLLVKSDVYSYGVVLLELLSGRKP 409 GT Y+APE V SDV+S G+ +LE+ +G+ P Sbjct: 382 FTGTSFYMAPERIQGQPYSVTSDVWSLGLTILEVANGKFP 421
>MKH1_SCHPO (Q10407) MAP kinase kinase kinase mkh1 (EC 2.7.11.25)| Length = 1116 Score = 71.6 bits (174), Expect = 8e-13 Identities = 44/134 (32%), Positives = 71/134 (52%), Gaps = 3/134 (2%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 + E V GS+ L YGP + ++ GL+YLH +IHRD KA Sbjct: 907 IFLEYVSGGSIGRCLRN----YGPFEEQLVRFVSRQVLYGLSYLHSKG---IIHRDLKAD 959 Query: 197 NVLLENDFTAKVADFGLAKEASEGIEH-ISTQVMGTFGYVAPEYAMTGH--LLVKSDVYS 367 N+L++ D K++DFG++K + ++ + + G+ ++APE H K DV+S Sbjct: 960 NLLIDFDGVCKISDFGISKHSDNVYDNDANLSMQGSIFWMAPEVIHNDHQGYSAKVDVWS 1019 Query: 368 YGVVLLELLSGRKP 409 G V+LE+L+GR+P Sbjct: 1020 LGCVVLEMLAGRRP 1033
>SPK1_DUGTI (P42687) Tyrosine-protein kinase SPK-1 (EC 2.7.10.2)| Length = 497 Score = 71.6 bits (174), Expect = 8e-13 Identities = 46/129 (35%), Positives = 73/129 (56%), Gaps = 2/129 (1%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 ++ E + NGS++ +L D L+ M + + G+AYL + V+HRD +A Sbjct: 292 IIVEYMKNGSLKEYLKTPDGKKTNLNQMVHMMAEI--SEGMAYLESEK---VVHRDLRAD 346 Query: 197 NVLLENDFTAKVADFGLAK--EASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYSY 370 N+L+ ND T KVADFGL + + S G + T + + + APE A + KSDV+SY Sbjct: 347 NILVANDLTRKVADFGLTELTDGSLGDQEKKT-LRFPYKWTAPEAAKSKVFTSKSDVWSY 405 Query: 371 GVVLLELLS 397 G+V+ E+L+ Sbjct: 406 GIVMFEILT 414
>M3K13_PONPY (Q5R8X7) Mitogen-activated protein kinase kinase kinase 13 (EC| 2.7.11.25) Length = 966 Score = 71.6 bits (174), Expect = 8e-13 Identities = 47/132 (35%), Positives = 69/132 (52%) Frame = +2 Query: 14 CLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKA 193 C++ E +G + L KI L D + G A G+ YLH +IHRD K+ Sbjct: 230 CIIMEYCAHGQLYEVLRAGRKITPRLLVDW----STGIASGMNYLHLHK---IIHRDLKS 282 Query: 194 SNVLLENDFTAKVADFGLAKEASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYSYG 373 NVL+ + K++DFG +KE S+ +S GT ++APE + K D++S+G Sbjct: 283 PNVLVTHTDAVKISDFGTSKELSDKSTKMS--FAGTVAWLAPEVIRNEPVSEKVDIWSFG 340 Query: 374 VVLLELLSGRKP 409 VVL ELL+G P Sbjct: 341 VVLWELLTGEIP 352
>M3K13_HUMAN (O43283) Mitogen-activated protein kinase kinase kinase 13 (EC| 2.7.11.25) (Mixed lineage kinase) (MLK) (Leucine zipper-bearing kinase) Length = 966 Score = 71.6 bits (174), Expect = 8e-13 Identities = 47/132 (35%), Positives = 69/132 (52%) Frame = +2 Query: 14 CLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKA 193 C++ E +G + L KI L D + G A G+ YLH +IHRD K+ Sbjct: 230 CIIMEYCAHGQLYEVLRAGRKITPRLLVDW----STGIASGMNYLHLHK---IIHRDLKS 282 Query: 194 SNVLLENDFTAKVADFGLAKEASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYSYG 373 NVL+ + K++DFG +KE S+ +S GT ++APE + K D++S+G Sbjct: 283 PNVLVTHTDAVKISDFGTSKELSDKSTKMS--FAGTVAWMAPEVIRNEPVSEKVDIWSFG 340 Query: 374 VVLLELLSGRKP 409 VVL ELL+G P Sbjct: 341 VVLWELLTGEIP 352
>IRAK3_HUMAN (Q9Y616) Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1)| (IRAK-3) (IL-1 receptor-associated kinase M) (IRAK-M) Length = 596 Score = 71.6 bits (174), Expect = 8e-13 Identities = 44/139 (31%), Positives = 74/139 (53%), Gaps = 6/139 (4%) Frame = +2 Query: 14 CLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKA 193 CL++ + NG++ L PL + R+ I +G ++ + YLH VI + Sbjct: 238 CLIYPYMRNGTLFDRLQCVGDT-APLPWHIRIGILIGISKAIHYLHNVQPCSVICGSISS 296 Query: 194 SNVLLENDFTAKVADFGLAKEASEGIEHISTQVMGTFG------YVAPEYAMTGHLLVKS 355 +N+LL++ F K+ DF +A S +EH S + T Y+ EY G L +K+ Sbjct: 297 ANILLDDQFQPKLTDFAMAHFRSH-LEHQSCTINMTSSSSKHLWYMPEEYIRQGKLSIKT 355 Query: 356 DVYSYGVVLLELLSGRKPV 412 DVYS+G+V++E+L+G + V Sbjct: 356 DVYSFGIVIMEVLTGCRVV 374
>LRRK1_MOUSE (Q3UHC2) Leucine-rich repeat serine/threonine-protein kinase 1 (EC| 2.7.11.1) Length = 2014 Score = 71.6 bits (174), Expect = 8e-13 Identities = 51/140 (36%), Positives = 76/140 (54%), Gaps = 8/140 (5%) Frame = +2 Query: 14 CLVFELVPNGSVESHL--HGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDF 187 C EL P GS+ + L + D + PL KIA A GLAYLH+ ++I D Sbjct: 1331 CFALELAPLGSLNTVLSENAKDSSFMPLGHMLTQKIAYQIASGLAYLHKK---NIIFCDL 1387 Query: 188 KASNVLL-----ENDFTAKVADFGLAKEA-SEGIEHISTQVMGTFGYVAPEYAMTGHLLV 349 K+ N+L+ + K++D+G+++++ EG + V GT GY APE Sbjct: 1388 KSDNILVWSLSAKEHINIKLSDYGISRQSFHEG----ALGVEGTPGYQAPEIRPRIVYDE 1443 Query: 350 KSDVYSYGVVLLELLSGRKP 409 K D++SYG+VL ELLSG++P Sbjct: 1444 KVDMFSYGMVLYELLSGQRP 1463
>MP2K2_HUMAN (P36507) Dual specificity mitogen-activated protein kinase kinase 2| (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2) Length = 400 Score = 71.6 bits (174), Expect = 8e-13 Identities = 38/101 (37%), Positives = 61/101 (60%) Frame = +2 Query: 110 KIALGAARGLAYLHEDANPHVIHRDFKASNVLLENDFTAKVADFGLAKEASEGIEHISTQ 289 K+++ RGLAYL E ++HRD K SN+L+ + K+ DFG++ + I+ ++ Sbjct: 172 KVSIAVLRGLAYLRE--KHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQL---IDSMANS 226 Query: 290 VMGTFGYVAPEYAMTGHLLVKSDVYSYGVVLLELLSGRKPV 412 +GT Y+APE H V+SD++S G+ L+EL GR P+ Sbjct: 227 FVGTRSYMAPERLQGTHYSVQSDIWSMGLSLVELAVGRYPI 267
>PKN2_COREF (Q8FUI4) Serine/threonine protein kinases drp72 (EC 2.7.11.1)| Length = 520 Score = 71.2 bits (173), Expect = 1e-12 Identities = 42/109 (38%), Positives = 61/109 (55%) Frame = +2 Query: 83 GPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKASNVLLENDFTAKVADFGLAKEAS 262 G L + + + AA GL+ +H ++HRD K N+L+ + K+ DFG+AK A+ Sbjct: 118 GALPEELALDVMEQAAHGLSVIHRMG---LVHRDIKPGNMLITANGILKITDFGIAKAAA 174 Query: 263 EGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYSYGVVLLELLSGRKP 409 + V+GT YV+PE A + SDVYS GVV E+LSGR+P Sbjct: 175 SVPLTRTGMVVGTAQYVSPEQAQGHQVTPASDVYSLGVVGYEMLSGRRP 223
>MLTK_MOUSE (Q9ESL4) Mitogen-activated protein kinase kinase kinase MLT (EC| 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper-and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) ( Length = 802 Score = 71.2 bits (173), Expect = 1e-12 Identities = 46/131 (35%), Positives = 70/131 (53%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 +V E GS+ +++ + +D + M A A+G+ YLH +A VIHRD K+ Sbjct: 80 IVTEYASLGSLYDYINSNRS--EEMDMEHIMTWATDVAKGMHYLHMEAPVKVIHRDLKSR 137 Query: 197 NVLLENDFTAKVADFGLAKEASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYSYGV 376 NV++ D K+ DFG A H+S ++GTF ++APE + + D YSYGV Sbjct: 138 NVVIAADGVLKICDFG-ASRFHNHTTHMS--LVGTFPWMAPEVIQSLPVSETCDTYSYGV 194 Query: 377 VLLELLSGRKP 409 VL E+L+ P Sbjct: 195 VLWEMLTREVP 205
>AVR2B_PIG (Q66T47) Activin receptor type 2B precursor (EC 2.7.11.30) (Activin| receptor type IIB) (ACTR-IIB) Length = 512 Score = 71.2 bits (173), Expect = 1e-12 Identities = 51/139 (36%), Positives = 72/139 (51%), Gaps = 14/139 (10%) Frame = +2 Query: 41 GSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDA--------NPHVIHRDFKAS 196 GS+ +L G+ + L +A +RGL+YLHED P + HRDFK+ Sbjct: 271 GSLTDYLKGNIITWNEL-----CHVAETMSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSK 325 Query: 197 NVLLENDFTAKVADFGLAKEASEGIEHISTQ-VMGTFGYVAPEYA-----MTGHLLVKSD 358 NVLL++D TA +ADFGLA G T +GT Y+APE + ++ D Sbjct: 326 NVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQVGTRRYMAPEVLEGAINFQRNAFLRID 385 Query: 359 VYSYGVVLLELLSGRKPVD 415 +Y+ G+VL EL+S K D Sbjct: 386 MYAMGLVLWELVSRCKAAD 404
>PKN2_CORGL (Q8NU97) Serine/threonine protein kinases pknA (EC 2.7.11.1)| Length = 469 Score = 70.9 bits (172), Expect = 1e-12 Identities = 40/109 (36%), Positives = 61/109 (55%) Frame = +2 Query: 83 GPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKASNVLLENDFTAKVADFGLAKEAS 262 G L D + + AA GL+ +H ++HRD K N+L+ + K+ DFG+AK A+ Sbjct: 118 GRLPEDLALDVMEQAAHGLSVIHR---MDMVHRDIKPGNMLITANGIVKITDFGIAKAAA 174 Query: 263 EGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYSYGVVLLELLSGRKP 409 + V+GT YV+PE A + SD+YS GVV E+++GR+P Sbjct: 175 AVPLTRTGMVVGTAQYVSPEQAQGKEVTAASDIYSLGVVGYEMMAGRRP 223
>PK1_STRTO (Q9KIG4) Serine/threonine-protein kinase PK-1 (EC 2.7.11.1)| (stoPK-1) Length = 641 Score = 70.9 bits (172), Expect = 1e-12 Identities = 43/114 (37%), Positives = 62/114 (54%) Frame = +2 Query: 89 LDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKASNVLLENDFTAKVADFGLAKEASEG 268 LD + ALGAA + +HRD K NVL+ +D KVADFGL + A + Sbjct: 119 LDILEPVLAALGAAHRAGF---------VHRDMKPENVLIGDDGRVKVADFGLVR-AVDS 168 Query: 269 IEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYSYGVVLLELLSGRKPVDMTQPS 430 + + + V+GT Y+APE G + DVY+ G++L E+L+G KP D P+ Sbjct: 169 VTNTTGTVLGTVSYLAPEQIEHGTADPRVDVYACGILLYEMLTGEKPHDGDSPA 222
>AVR2B_HUMAN (Q13705) Activin receptor type 2B precursor (EC 2.7.11.30) (Activin| receptor type IIB) (ACTR-IIB) Length = 512 Score = 70.9 bits (172), Expect = 1e-12 Identities = 52/140 (37%), Positives = 74/140 (52%), Gaps = 15/140 (10%) Frame = +2 Query: 41 GSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDA--------NPHVIHRDFKAS 196 GS+ +L G+ + L +A +RGL+YLHED P + HRDFK+ Sbjct: 271 GSLTDYLKGNIITWNEL-----CHVAETMSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSK 325 Query: 197 NVLLENDFTAKVADFGLAKEASEGIEHISTQ-VMGTFGYVAPEYAMTGHL------LVKS 355 NVLL++D TA +ADFGLA G T +GT Y+APE + G + ++ Sbjct: 326 NVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQVGTRRYMAPE-VLEGAINFQRDAFLRI 384 Query: 356 DVYSYGVVLLELLSGRKPVD 415 D+Y+ G+VL EL+S K D Sbjct: 385 DMYAMGLVLWELVSRCKAAD 404
>AVR2B_BOVIN (Q95126) Activin receptor type 2B precursor (EC 2.7.11.30) (Activin| receptor type IIB) (ACTR-IIB) Length = 512 Score = 70.9 bits (172), Expect = 1e-12 Identities = 52/140 (37%), Positives = 74/140 (52%), Gaps = 15/140 (10%) Frame = +2 Query: 41 GSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDA--------NPHVIHRDFKAS 196 GS+ +L G+ + L +A +RGL+YLHED P + HRDFK+ Sbjct: 271 GSLTDYLKGNIITWNEL-----CHVAETMSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSK 325 Query: 197 NVLLENDFTAKVADFGLAKEASEGIEHISTQ-VMGTFGYVAPEYAMTGHL------LVKS 355 NVLL++D TA +ADFGLA G T +GT Y+APE + G + ++ Sbjct: 326 NVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQVGTRRYMAPE-VLEGAINFQRDAFLRI 384 Query: 356 DVYSYGVVLLELLSGRKPVD 415 D+Y+ G+VL EL+S K D Sbjct: 385 DMYAMGLVLWELVSRCKAAD 404
>AVR2B_MOUSE (P27040) Activin receptor type 2B precursor (EC 2.7.11.30) (Activin| receptor type IIB) (ACTR-IIB) Length = 536 Score = 70.9 bits (172), Expect = 1e-12 Identities = 52/140 (37%), Positives = 74/140 (52%), Gaps = 15/140 (10%) Frame = +2 Query: 41 GSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDA--------NPHVIHRDFKAS 196 GS+ +L G+ + L +A +RGL+YLHED P + HRDFK+ Sbjct: 295 GSLTDYLKGNIITWNEL-----CHVAETMSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSK 349 Query: 197 NVLLENDFTAKVADFGLAKEASEGIEHISTQ-VMGTFGYVAPEYAMTGHL------LVKS 355 NVLL++D TA +ADFGLA G T +GT Y+APE + G + ++ Sbjct: 350 NVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQVGTRRYMAPE-VLEGAINFQRDAFLRI 408 Query: 356 DVYSYGVVLLELLSGRKPVD 415 D+Y+ G+VL EL+S K D Sbjct: 409 DMYAMGLVLWELVSRCKAAD 428
>MP2K2_MOUSE (Q63932) Dual specificity mitogen-activated protein kinase kinase 2| (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2) Length = 401 Score = 70.9 bits (172), Expect = 1e-12 Identities = 43/132 (32%), Positives = 73/132 (55%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 + E + GS++ L + +I D K+++ RGLAYL E ++HRD K S Sbjct: 145 ICMEHMDGGSLDQVLKEAKRI----PEDILGKVSIAVLRGLAYLRE--KHQIMHRDVKPS 198 Query: 197 NVLLENDFTAKVADFGLAKEASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYSYGV 376 N+L+ + K+ DFG++ + I+ ++ +GT Y++PE H V+SD++S G+ Sbjct: 199 NILVNSRGEIKLCDFGVSGQL---IDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGL 255 Query: 377 VLLELLSGRKPV 412 L+EL GR P+ Sbjct: 256 SLVELAIGRYPI 267
>AVR2B_RAT (P38445) Activin receptor type 2B precursor (EC 2.7.11.30) (Activin| receptor type IIB) (ACTR-IIB) Length = 513 Score = 70.9 bits (172), Expect = 1e-12 Identities = 52/140 (37%), Positives = 74/140 (52%), Gaps = 15/140 (10%) Frame = +2 Query: 41 GSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDA--------NPHVIHRDFKAS 196 GS+ +L G+ + L +A +RGL+YLHED P + HRDFK+ Sbjct: 272 GSLTDYLKGNIITWNEL-----CHVAETMSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSK 326 Query: 197 NVLLENDFTAKVADFGLAKEASEGIEHISTQ-VMGTFGYVAPEYAMTGHL------LVKS 355 NVLL++D TA +ADFGLA G T +GT Y+APE + G + ++ Sbjct: 327 NVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQVGTRRYMAPE-VLEGAINFQRDAFLRI 385 Query: 356 DVYSYGVVLLELLSGRKPVD 415 D+Y+ G+VL EL+S K D Sbjct: 386 DMYAMGLVLWELVSRCKAAD 405
>SRK4_SPOLA (P42690) Tyrosine-protein kinase isoform SRK4 (EC 2.7.10.2)| Length = 506 Score = 70.9 bits (172), Expect = 1e-12 Identities = 46/132 (34%), Positives = 69/132 (52%), Gaps = 1/132 (0%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 +V EL+ +GS+ +L G + L + + A G++YL + + IHRD A Sbjct: 310 IVTELMKHGSLLEYLRGDGR---SLKLPDLVDMCSQVASGMSYLEQQ---NYIHRDLAAR 363 Query: 197 NVLLENDFTAKVADFGLAKEASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYSYGV 376 N+L+ KVADFGLA+ E I + APE AM +KSDV+S+G+ Sbjct: 364 NILVGEHKICKVADFGLARVIDEEIYEAKLGAKFPIKWTAPEAAMYSRFTIKSDVWSFGI 423 Query: 377 VLLELLS-GRKP 409 VL E+++ GR P Sbjct: 424 VLYEVITYGRFP 435
>MP2K2_RAT (P36506) Dual specificity mitogen-activated protein kinase kinase 2| (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2) Length = 400 Score = 70.9 bits (172), Expect = 1e-12 Identities = 43/132 (32%), Positives = 73/132 (55%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 + E + GS++ L + +I D K+++ RGLAYL E ++HRD K S Sbjct: 145 ICMEHMDGGSLDQVLKEAKRI----PEDILGKVSIAVLRGLAYLRE--KHQIMHRDVKPS 198 Query: 197 NVLLENDFTAKVADFGLAKEASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYSYGV 376 N+L+ + K+ DFG++ + I+ ++ +GT Y++PE H V+SD++S G+ Sbjct: 199 NILVNSRGEIKLCDFGVSGQL---IDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGL 255 Query: 377 VLLELLSGRKPV 412 L+EL GR P+ Sbjct: 256 SLVELAIGRYPI 267
>M3K12_RAT (Q63796) Mitogen-activated protein kinase kinase kinase 12 (EC| 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK) Length = 888 Score = 70.5 bits (171), Expect = 2e-12 Identities = 46/132 (34%), Positives = 67/132 (50%) Frame = +2 Query: 14 CLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKA 193 C++ E G + L + L D M G A G+ YLH +IHRD K+ Sbjct: 220 CILMEFCAQGQLYEVLRAGRPVTPSLLVDWSM----GIAGGMNYLHLHK---IIHRDLKS 272 Query: 194 SNVLLENDFTAKVADFGLAKEASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYSYG 373 N+L+ D K++DFG +KE S+ +S GT ++APE + K D++S+G Sbjct: 273 PNMLITYDDVVKISDFGTSKELSDKSTKMS--FAGTVAWMAPEVIRNEPVSEKVDIWSFG 330 Query: 374 VVLLELLSGRKP 409 VVL ELL+G P Sbjct: 331 VVLWELLTGEIP 342
>M3K12_MOUSE (Q60700) Mitogen-activated protein kinase kinase kinase 12 (EC| 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK) Length = 888 Score = 70.5 bits (171), Expect = 2e-12 Identities = 46/132 (34%), Positives = 67/132 (50%) Frame = +2 Query: 14 CLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKA 193 C++ E G + L + L D M G A G+ YLH +IHRD K+ Sbjct: 220 CILMEFCAQGQLYEVLRAGRPVTPSLLVDWSM----GIAGGMNYLHLHK---IIHRDLKS 272 Query: 194 SNVLLENDFTAKVADFGLAKEASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYSYG 373 N+L+ D K++DFG +KE S+ +S GT ++APE + K D++S+G Sbjct: 273 PNMLITYDDVVKISDFGTSKELSDKSTKMS--FAGTVAWMAPEVIRNEPVSEKVDIWSFG 330 Query: 374 VVLLELLSGRKP 409 VVL ELL+G P Sbjct: 331 VVLWELLTGEIP 342
>M3K12_HUMAN (Q12852) Mitogen-activated protein kinase kinase kinase 12 (EC| 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK) Length = 859 Score = 70.5 bits (171), Expect = 2e-12 Identities = 46/132 (34%), Positives = 67/132 (50%) Frame = +2 Query: 14 CLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKA 193 C++ E G + L + L D M G A G+ YLH +IHRD K+ Sbjct: 187 CILMEFCAQGQLYEVLRAGRPVTPSLLVDWSM----GIAGGMNYLHLHK---IIHRDLKS 239 Query: 194 SNVLLENDFTAKVADFGLAKEASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYSYG 373 N+L+ D K++DFG +KE S+ +S GT ++APE + K D++S+G Sbjct: 240 PNMLITYDDVVKISDFGTSKELSDKSTKMS--FAGTVAWMAPEVIRNEPVSEKVDIWSFG 297 Query: 374 VVLLELLSGRKP 409 VVL ELL+G P Sbjct: 298 VVLWELLTGEIP 309
>PTK6_MOUSE (Q64434) Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related| intestinal kinase) Length = 451 Score = 70.5 bits (171), Expect = 2e-12 Identities = 49/136 (36%), Positives = 75/136 (55%), Gaps = 5/136 (3%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPL----DFDTRMKIALGAARGLAYLHEDANPHVIHRD 184 ++ EL+P G++ L SD+ P+ DF +++ A G+ YL + IHRD Sbjct: 262 IITELMPKGNLLQLLRDSDEKALPILELVDFASQV------AEGMCYLESQ---NYIHRD 312 Query: 185 FKASNVLLENDFTAKVADFGLAKEASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVY 364 A NVL+ + KV DFGLA+ E I ++S + + + APE GH +KSDV+ Sbjct: 313 LAARNVLVTENNLCKVGDFGLARLVKEDI-YLSHEHNVPYKWTAPEALSRGHYSIKSDVW 371 Query: 365 SYGVVLLELLS-GRKP 409 S+GV+L E+ S G+ P Sbjct: 372 SFGVLLHEIFSRGQMP 387
>PKNL_MYCTU (O53510) Probable serine/threonine-protein kinase pknL (EC| 2.7.11.1) Length = 399 Score = 70.5 bits (171), Expect = 2e-12 Identities = 43/131 (32%), Positives = 67/131 (51%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 LV EL+ G++ L GP+ + + GLA H ++HRD K Sbjct: 94 LVMELIEGGTLRELLIER----GPMPPHAVVAVLRPVLGGLAAAHRAG---LVHRDVKPE 146 Query: 197 NVLLENDFTAKVADFGLAKEASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYSYGV 376 N+L+ +D K+ADFGL + + + ++GT Y++PE G+ +SDVYS GV Sbjct: 147 NILISDDGDVKLADFGLVRAVAAASITSTGVILGTAAYLSPEQVRDGNADPRSDVYSVGV 206 Query: 377 VLLELLSGRKP 409 ++ ELL+G P Sbjct: 207 LVYELLTGHTP 217
>PKNL_MYCBO (Q7TYY6) Probable serine/threonine-protein kinase pknL (EC| 2.7.11.1) Length = 399 Score = 70.5 bits (171), Expect = 2e-12 Identities = 43/131 (32%), Positives = 67/131 (51%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 LV EL+ G++ L GP+ + + GLA H ++HRD K Sbjct: 94 LVMELIEGGTLRELLIER----GPMPPHAVVAVLRPVLGGLAAAHRAG---LVHRDVKPE 146 Query: 197 NVLLENDFTAKVADFGLAKEASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYSYGV 376 N+L+ +D K+ADFGL + + + ++GT Y++PE G+ +SDVYS GV Sbjct: 147 NILISDDGDVKLADFGLVRAVAAASITSTGVILGTAAYLSPEQVRDGNADPRSDVYSVGV 206 Query: 377 VLLELLSGRKP 409 ++ ELL+G P Sbjct: 207 LVYELLTGHTP 217
>AVR2B_XENLA (P27041) Activin receptor type 2B precursor (EC 2.7.11.30) (Activin| receptor type IIB) (ACTR-IIB) Length = 511 Score = 70.1 bits (170), Expect = 2e-12 Identities = 46/105 (43%), Positives = 60/105 (57%), Gaps = 15/105 (14%) Frame = +2 Query: 128 ARGLAYLHEDA--------NPHVIHRDFKASNVLLENDFTAKVADFGLAKEASEGIEHIS 283 ARGLAYLHED P + HRDFK+ NVLL ND TA +ADFGLA G Sbjct: 294 ARGLAYLHEDVPRCKGEGHKPAIAHRDFKSKNVLLRNDLTAILADFGLAVRFEPGKPPGD 353 Query: 284 TQ-VMGTFGYVAPEYAMTGHL------LVKSDVYSYGVVLLELLS 397 T +GT Y+APE + G + ++ D+Y+ G+VL E++S Sbjct: 354 THGQVGTRRYMAPE-VLEGAINFQRDSFLRIDMYAMGLVLWEIVS 397
>MP2K2_CHICK (Q90891) Dual specificity mitogen-activated protein kinase kinase 2| (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2) Length = 398 Score = 70.1 bits (170), Expect = 2e-12 Identities = 37/101 (36%), Positives = 61/101 (60%) Frame = +2 Query: 110 KIALGAARGLAYLHEDANPHVIHRDFKASNVLLENDFTAKVADFGLAKEASEGIEHISTQ 289 K+++ RGLAYL E ++HRD K SN+L+ + K+ DFG++ + I+ ++ Sbjct: 170 KVSIAVLRGLAYLRE--KHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQL---IDSMANS 224 Query: 290 VMGTFGYVAPEYAMTGHLLVKSDVYSYGVVLLELLSGRKPV 412 +GT Y++PE H V+SD++S G+ L+EL GR P+ Sbjct: 225 FVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVELSIGRYPI 265
>PKNB_MYCLE (P54744) Probable serine/threonine-protein kinase pknB (EC| 2.7.11.1) Length = 622 Score = 70.1 bits (170), Expect = 2e-12 Identities = 42/132 (31%), Positives = 69/132 (52%), Gaps = 1/132 (0%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 +V E V ++ +H GP+ ++I A + L + H++ +IHRD K + Sbjct: 90 IVMEYVDGATLRDIVHTD----GPMPPQQAIEIVADACQALNFSHQNG---IIHRDVKPA 142 Query: 197 NVLLENDFTAKVADFGLAKEASEGIEHISTQ-VMGTFGYVAPEYAMTGHLLVKSDVYSYG 373 N+++ KV DFG+A+ ++ T V+GT Y++PE A + +SDVYS G Sbjct: 143 NIMISATNAVKVMDFGIARAIADSTSVTQTAAVIGTAQYLSPEQARGDSVDARSDVYSLG 202 Query: 374 VVLLELLSGRKP 409 VL E+L+G P Sbjct: 203 CVLYEILTGEPP 214
>PKNA2_BIFLO (Q8G4G1) Probable serine/threonine-protein kinase pknA2 (EC| 2.7.11.1) Length = 757 Score = 69.7 bits (169), Expect = 3e-12 Identities = 35/107 (32%), Positives = 56/107 (52%) Frame = +2 Query: 107 MKIALGAARGLAYLHEDANPHVIHRDFKASNVLLENDFTAKVADFGLAKEASEGIEHIST 286 +++ GLA H V+HRD K N+L+ + ++ DFGLAK AS+ + Sbjct: 118 LRVVAETLDGLASAHRAG---VVHRDIKPENILINDRGHVQITDFGLAKAASQATLSSTG 174 Query: 287 QVMGTFGYVAPEYAMTGHLLVKSDVYSYGVVLLELLSGRKPVDMTQP 427 ++GT Y+APE + D+YS G++ E+L+G+ P D P Sbjct: 175 MLLGTAAYLAPEMIENNQATAQGDLYSVGIMAWEMLTGKVPFDSDNP 221
>RAF1_XENLA (P09560) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (C-RAF) Length = 638 Score = 69.7 bits (169), Expect = 3e-12 Identities = 47/136 (34%), Positives = 70/136 (51%), Gaps = 5/136 (3%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 +V + S+ HLH D + + IA A+G+ YLH ++IHRD K++ Sbjct: 410 IVTQWCEGSSLYYHLHVLDTKFQMFQL---IDIARQTAQGMDYLHAK---NIIHRDMKSN 463 Query: 197 NVLLENDFTAKVADFGLA--KEASEGIEHISTQVMGTFGYVAPEYAM---TGHLLVKSDV 361 N+ L T K+ DFGLA K G + + Q+ G+ ++APE +SDV Sbjct: 464 NIFLHEGLTVKIGDFGLATVKTRWSGSQQVE-QLTGSILWMAPEVIRMQDNNPFSFQSDV 522 Query: 362 YSYGVVLLELLSGRKP 409 YSYG+VL EL++G P Sbjct: 523 YSYGIVLYELMTGELP 538
>MATK_MOUSE (P41242) Megakaryocyte-associated tyrosine-protein kinase (EC| 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK) Length = 505 Score = 69.7 bits (169), Expect = 3e-12 Identities = 42/102 (41%), Positives = 58/102 (56%), Gaps = 1/102 (0%) Frame = +2 Query: 107 MKIALGAARGLAYLHEDANPHVIHRDFKASNVLLENDFTAKVADFGLAKEASEGIEHIST 286 ++ AL A G+ YL + ++HRD A N+L+ D AKV+DFGLAK +G++ Sbjct: 328 LQFALHVAEGMEYLE---SKKLVHRDLAARNILVSEDLVAKVSDFGLAKAERKGLDSSRL 384 Query: 287 QVMGTFGYVAPEYAMTGHLLVKSDVYSYGVVLLELLS-GRKP 409 V T APE G KSDV+S+GV+L E+ S GR P Sbjct: 385 PVKWT----APEALKNGRFSSKSDVWSFGVLLWEVFSYGRAP 422
>PKN2_CLOPE (Q8XJL8) Probable serine/threonine protein kinase CPE1738 (EC| 2.7.11.1) Length = 685 Score = 69.7 bits (169), Expect = 3e-12 Identities = 37/115 (32%), Positives = 60/115 (52%) Frame = +2 Query: 83 GPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKASNVLLENDFTAKVADFGLAKEAS 262 G L ++ + I + A+ L H+ +IHRD K N+L+ + KV DFG+AK Sbjct: 103 GALPYEVAISIGIKVAKALECAHKSG---IIHRDVKPQNILVTEEGVVKVTDFGIAKSMD 159 Query: 263 EGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYSYGVVLLELLSGRKPVDMTQP 427 + VMG+ Y +PE A + ++D+YS G+VL E+++G P + P Sbjct: 160 SSTIAHTNSVMGSAHYFSPEQAKGTYTDYRTDLYSLGIVLYEMVTGVVPFNGDSP 214
>LCK_MOUSE (P06240) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) Length = 508 Score = 69.7 bits (169), Expect = 3e-12 Identities = 46/145 (31%), Positives = 77/145 (53%), Gaps = 2/145 (1%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 ++ E + NGS+ L I L+ + + +A A G+A++ E + IHRD +A+ Sbjct: 313 IITEYMENGSLVDFLKTPSGI--KLNVNKLLDMAAQIAEGMAFIEEQ---NYIHRDLRAA 367 Query: 197 NVLLENDFTAKVADFGLAKEASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYSYGV 376 N+L+ + + K+ADFGLA+ + + APE G +KSDV+S+G+ Sbjct: 368 NILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGI 427 Query: 377 VLLELLS-GRKPV-DMTQPSGSENL 445 +L E+++ GR P MT P +NL Sbjct: 428 LLTEIVTHGRIPYPGMTNPEVIQNL 452
>CDC7_SCHPO (P41892) Cell division control protein 7 (EC 2.7.11.1)| Length = 1062 Score = 69.7 bits (169), Expect = 3e-12 Identities = 46/141 (32%), Positives = 70/141 (49%) Frame = +2 Query: 14 CLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKA 193 C++ E NGS+ S K +G + + +GL YLH N VIHRD K Sbjct: 82 CIILEYCENGSLRSIC----KNFGKIPENLVALYTFQVLQGLLYLH---NQGVIHRDIKG 134 Query: 194 SNVLLENDFTAKVADFGLAKEASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYSYG 373 +N+L D T K+ADFG+A + + +H V+G+ ++APE SD++S G Sbjct: 135 ANILTTKDGTIKLADFGVATKINALEDH---SVVGSPYWMAPEVIELVGATTASDIWSVG 191 Query: 374 VVLLELLSGRKPVDMTQPSGS 436 ++ELL G P P+ + Sbjct: 192 CTVIELLDGNPPYYDLDPTSA 212
>BYR1_SCHPO (P10506) Protein kinase byr1 (EC 2.7.12.2) (MAPK kinase) (MAPKK)| Length = 340 Score = 69.3 bits (168), Expect = 4e-12 Identities = 43/131 (32%), Positives = 69/131 (52%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 L E + GS+++ L GP+ D KI +GL YL+ H+IHRD K S Sbjct: 137 LCMEYMDCGSLDAILREG----GPIPLDILGKIINSMVKGLIYLYNVL--HIIHRDLKPS 190 Query: 197 NVLLENDFTAKVADFGLAKEASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYSYGV 376 NV++ + K+ DFG++ E + ++ +GT Y++PE G VKSD++S G+ Sbjct: 191 NVVVNSRGEIKLCDFGVSGEL---VNSVAQTFVGTSTYMSPERIRGGKYTVKSDIWSLGI 247 Query: 377 VLLELLSGRKP 409 ++EL + P Sbjct: 248 SIIELATQELP 258
>MIL_AVIMH (P00531) Serine/threonine-protein kinase transforming protein mil| (EC 2.7.11.1) Length = 380 Score = 69.3 bits (168), Expect = 4e-12 Identities = 46/136 (33%), Positives = 70/136 (51%), Gaps = 5/136 (3%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 +V + S+ HLH + + + IA A+G+ YLH ++IHRD K++ Sbjct: 152 IVTQWCEGSSLYKHLHVQETKFQMFQL---IDIARQTAQGMDYLHAK---NIIHRDMKSN 205 Query: 197 NVLLENDFTAKVADFGLA--KEASEGIEHISTQVMGTFGYVAPEYAM---TGHLLVKSDV 361 N+ L T K+ DFGLA K G + + Q G+ ++APE + +SDV Sbjct: 206 NIFLHGGLTVKIGDFGLATVKSRWSGSQQVE-QPTGSILWMAPEVIRMQDSNPFSFQSDV 264 Query: 362 YSYGVVLLELLSGRKP 409 YSYG+VL EL++G P Sbjct: 265 YSYGIVLYELMTGELP 280
>STE11_YEAST (P23561) Serine/threonine-protein kinase STE11 (EC 2.7.11.1)| Length = 738 Score = 69.3 bits (168), Expect = 4e-12 Identities = 40/133 (30%), Positives = 70/133 (52%), Gaps = 2/133 (1%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 + E VP GSV S L+ YGP + G+AYLH+ ++IHRD K + Sbjct: 552 IFLEYVPGGSVSSMLNN----YGPFEESLITNFTRQILIGVAYLHKK---NIIHRDIKGA 604 Query: 197 NVLLENDFTAKVADFGLAKEAS--EGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYSY 370 N+L++ K+ DFG++K+ S ++ + G+ +++PE K+D++S Sbjct: 605 NILIDIKGCVKITDFGISKKLSPLNKKQNKRASLQGSVFWMSPEVVKQTATTAKADIWST 664 Query: 371 GVVLLELLSGRKP 409 G V++E+ +G+ P Sbjct: 665 GCVVIEMFTGKHP 677
>RAF1_CHICK (P05625) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (RAF-1) (C-RAF) (MIL proto-oncogene serine/threonine-protein kinase) (C-MIL) Length = 647 Score = 69.3 bits (168), Expect = 4e-12 Identities = 46/136 (33%), Positives = 70/136 (51%), Gaps = 5/136 (3%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 +V + S+ HLH + + + IA A+G+ YLH ++IHRD K++ Sbjct: 419 IVTQWCEGSSLYKHLHVQETKFQMFQL---IDIARQTAQGMDYLHAK---NIIHRDMKSN 472 Query: 197 NVLLENDFTAKVADFGLA--KEASEGIEHISTQVMGTFGYVAPEYAM---TGHLLVKSDV 361 N+ L T K+ DFGLA K G + + Q G+ ++APE + +SDV Sbjct: 473 NIFLHEGLTVKIGDFGLATVKSRWSGSQQVE-QPTGSILWMAPEVIRMQDSNPFSFQSDV 531 Query: 362 YSYGVVLLELLSGRKP 409 YSYG+VL EL++G P Sbjct: 532 YSYGIVLYELMTGELP 547
>RMIL_AVII1 (P10533) Serine/threonine-protein kinase transforming protein Rmil| (EC 2.7.11.1) Length = 367 Score = 68.9 bits (167), Expect = 5e-12 Identities = 45/135 (33%), Positives = 71/135 (52%), Gaps = 4/135 (2%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 +V + S+ HLH + + + + IA A+G+ YLH + +IHRD K++ Sbjct: 137 IVTQWCEGSSLYHHLHIIETKFEMIKL---IDIARQTAQGMDYLHAKS---IIHRDLKSN 190 Query: 197 NVLLENDFTAKVADFGLAKEASE-GIEHISTQVMGTFGYVAPEYAM---TGHLLVKSDVY 364 N+ L D T K+ DFGLA S H Q+ G+ ++APE +SDVY Sbjct: 191 NIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVY 250 Query: 365 SYGVVLLELLSGRKP 409 ++G+VL EL++G+ P Sbjct: 251 AFGIVLYELMTGQLP 265
>RIPK4_HUMAN (P57078) Receptor-interacting serine/threonine-protein kinase 4 (EC| 2.7.11.1) (Ankyrin repeat domain protein 3) (PKC-delta-interacting protein kinase) Length = 832 Score = 68.9 bits (167), Expect = 5e-12 Identities = 49/137 (35%), Positives = 71/137 (51%), Gaps = 6/137 (4%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 LV E + GS+E L PL +D R +I A G+ +LH A P ++H D K + Sbjct: 94 LVMEYMETGSLEKLLASE-----PLPWDLRFRIIHETAVGMNFLHCMAPP-LLHLDLKPA 147 Query: 197 NVLLENDFTAKVADFGLAKEASEGIEHISTQVM----GTFGYVAPEYAMTGHLL--VKSD 358 N+LL+ + K++DFGLAK G+ H M GT Y+ PE L K D Sbjct: 148 NILLDAHYHVKISDFGLAK--CNGLSHSHDLSMDGLFGTIAYLPPERIREKSRLFDTKHD 205 Query: 359 VYSYGVVLLELLSGRKP 409 VYS+ +V+ +L+ +KP Sbjct: 206 VYSFAIVIWGVLTQKKP 222
>YRK_CHICK (Q02977) Proto-oncogene tyrosine-protein kinase Yrk (EC 2.7.10.2)| (p60-Yrk) (Yes-related kinase) Length = 535 Score = 68.9 bits (167), Expect = 5e-12 Identities = 44/132 (33%), Positives = 70/132 (53%), Gaps = 1/132 (0%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 +V E + GS+ L D Y L + +A A G+AY+ + IHRD +A+ Sbjct: 338 IVTEFMSQGSLLDFLKDGDGRY--LKLPQLVDMAAQIAAGMAYIER---MNYIHRDLRAA 392 Query: 197 NVLLENDFTAKVADFGLAKEASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYSYGV 376 N+L+ ++ K+ADFGLA+ + + APE A+ G +KSDV+S+G+ Sbjct: 393 NILVGDNLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALFGKFTIKSDVWSFGI 452 Query: 377 VLLELLS-GRKP 409 +L EL++ GR P Sbjct: 453 LLTELVTKGRVP 464
>RMIL_AVEVR (P27966) Serine/threonine-protein kinase transforming protein Rmil| (EC 2.7.11.1) Length = 450 Score = 68.9 bits (167), Expect = 5e-12 Identities = 45/135 (33%), Positives = 71/135 (52%), Gaps = 4/135 (2%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 +V + S+ HLH + + + + IA A+G+ YLH + +IHRD K++ Sbjct: 153 IVTQWCEGSSLYHHLHIIETKFEMIKL---IDIARQTAQGMDYLHAKS---IIHRDLKSN 206 Query: 197 NVLLENDFTAKVADFGLAKEASE-GIEHISTQVMGTFGYVAPEYAM---TGHLLVKSDVY 364 N+ L D T K+ DFGLA S H Q+ G+ ++APE +SDVY Sbjct: 207 NIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVY 266 Query: 365 SYGVVLLELLSGRKP 409 ++G+VL EL++G+ P Sbjct: 267 AFGIVLYELMTGQLP 281
>MP2K2_CYPCA (Q90321) Dual specificity mitogen-activated protein kinase kinase 2| (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2) Length = 397 Score = 68.9 bits (167), Expect = 5e-12 Identities = 37/101 (36%), Positives = 60/101 (59%) Frame = +2 Query: 110 KIALGAARGLAYLHEDANPHVIHRDFKASNVLLENDFTAKVADFGLAKEASEGIEHISTQ 289 K+++ RGL YL E ++HRD K SN+L+ + K+ DFG++ + I+ ++ Sbjct: 169 KVSIAVLRGLVYLRE--KHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQL---IDSMANS 223 Query: 290 VMGTFGYVAPEYAMTGHLLVKSDVYSYGVVLLELLSGRKPV 412 +GT Y++PE H V+SDV+S G+ L+EL GR P+ Sbjct: 224 FVGTRSYMSPERLQGTHYSVQSDVWSMGLSLVELAIGRFPI 264
>BRAF1_HUMAN (P15056) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (p94) (v-Raf murine sarcoma viral oncogene homolog B1) Length = 766 Score = 68.9 bits (167), Expect = 5e-12 Identities = 45/135 (33%), Positives = 71/135 (52%), Gaps = 4/135 (2%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 +V + S+ HLH + + + + IA A+G+ YLH + +IHRD K++ Sbjct: 527 IVTQWCEGSSLYHHLHIIETKFEMIKL---IDIARQTAQGMDYLHAKS---IIHRDLKSN 580 Query: 197 NVLLENDFTAKVADFGLAKEASE-GIEHISTQVMGTFGYVAPEYAM---TGHLLVKSDVY 364 N+ L D T K+ DFGLA S H Q+ G+ ++APE +SDVY Sbjct: 581 NIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVY 640 Query: 365 SYGVVLLELLSGRKP 409 ++G+VL EL++G+ P Sbjct: 641 AFGIVLYELMTGQLP 655
>BRAF1_COTJA (P34908) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (RMIL serine/threonine-protein kinase) (c-RMIL) Length = 807 Score = 68.9 bits (167), Expect = 5e-12 Identities = 45/135 (33%), Positives = 71/135 (52%), Gaps = 4/135 (2%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 +V + S+ HLH + + + + IA A+G+ YLH + +IHRD K++ Sbjct: 567 IVTQWCEGSSLYHHLHIIETKFEMIKL---IDIARQTAQGMDYLHAKS---IIHRDLKSN 620 Query: 197 NVLLENDFTAKVADFGLAKEASE-GIEHISTQVMGTFGYVAPEYAM---TGHLLVKSDVY 364 N+ L D T K+ DFGLA S H Q+ G+ ++APE +SDVY Sbjct: 621 NIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVY 680 Query: 365 SYGVVLLELLSGRKP 409 ++G+VL EL++G+ P Sbjct: 681 AFGIVLYELMTGQLP 695
>BRAF1_MOUSE (P28028) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Fragment) Length = 328 Score = 68.9 bits (167), Expect = 5e-12 Identities = 45/135 (33%), Positives = 71/135 (52%), Gaps = 4/135 (2%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 +V + S+ HLH + + + + IA A+G+ YLH + +IHRD K++ Sbjct: 89 IVTQWCEGSSLYHHLHIIETKFEMIKL---IDIARQTAQGMDYLHAKS---IIHRDLKSN 142 Query: 197 NVLLENDFTAKVADFGLAKEASE-GIEHISTQVMGTFGYVAPEYAM---TGHLLVKSDVY 364 N+ L D T K+ DFGLA S H Q+ G+ ++APE +SDVY Sbjct: 143 NIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVY 202 Query: 365 SYGVVLLELLSGRKP 409 ++G+VL EL++G+ P Sbjct: 203 AFGIVLYELMTGQLP 217
>BRAF1_CHICK (Q04982) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Rmil serine/threonine-protein kinase) (c-Rmil) Length = 806 Score = 68.9 bits (167), Expect = 5e-12 Identities = 45/135 (33%), Positives = 71/135 (52%), Gaps = 4/135 (2%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 +V + S+ HLH + + + + IA A+G+ YLH + +IHRD K++ Sbjct: 567 IVTQWCEGSSLYHHLHIIETKFEMIKL---IDIARQTAQGMDYLHAKS---IIHRDLKSN 620 Query: 197 NVLLENDFTAKVADFGLAKEASE-GIEHISTQVMGTFGYVAPEYAM---TGHLLVKSDVY 364 N+ L D T K+ DFGLA S H Q+ G+ ++APE +SDVY Sbjct: 621 NIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVY 680 Query: 365 SYGVVLLELLSGRKP 409 ++G+VL EL++G+ P Sbjct: 681 AFGIVLYELMTGQLP 695
>M3K1_ARATH (O22040) Mitogen-activated protein kinase kinase kinase 1 (EC| 2.7.11.25) (Arabidospsis NPK1-related protein kinase 1) Length = 666 Score = 68.6 bits (166), Expect = 7e-12 Identities = 44/133 (33%), Positives = 71/133 (53%), Gaps = 2/133 (1%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 ++ E VP GS+ S L +GP GL YLH A ++HRD K + Sbjct: 149 ILLEFVPGGSISSLLEK----FGPFPESVVRTYTRQLLLGLEYLHNHA---IMHRDIKGA 201 Query: 197 NVLLENDFTAKVADFGLAKEASEGIEHISTQVM-GTFGYVAPEYAM-TGHLLVKSDVYSY 370 N+L++N K+ADFG +K+ +E + M GT ++APE + TGH +D++S Sbjct: 202 NILVDNKGCIKLADFGASKQVAELATMTGAKSMKGTPYWMAPEVILQTGHSF-SADIWSV 260 Query: 371 GVVLLELLSGRKP 409 G ++E+++G+ P Sbjct: 261 GCTVIEMVTGKAP 273
>RAF1_RAT (P11345) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 68.6 bits (166), Expect = 7e-12 Identities = 46/136 (33%), Positives = 69/136 (50%), Gaps = 5/136 (3%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 +V + S+ HLH + + + IA A+G+ YLH ++IHRD K++ Sbjct: 419 IVTQWCEGSSLYKHLHVQETKFQMFQL---IDIARQTAQGMDYLHAK---NIIHRDMKSN 472 Query: 197 NVLLENDFTAKVADFGLA--KEASEGIEHISTQVMGTFGYVAPEYAM---TGHLLVKSDV 361 N+ L T K+ DFGLA K G + + Q G+ ++APE +SDV Sbjct: 473 NIFLHEGLTVKIGDFGLATVKSRWSGSQQVE-QPTGSVLWMAPEVIRMQDNNPFSFQSDV 531 Query: 362 YSYGVVLLELLSGRKP 409 YSYG+VL EL++G P Sbjct: 532 YSYGIVLYELMTGELP 547
>RAF1_HUMAN (P04049) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 68.6 bits (166), Expect = 7e-12 Identities = 46/136 (33%), Positives = 69/136 (50%), Gaps = 5/136 (3%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 +V + S+ HLH + + + IA A+G+ YLH ++IHRD K++ Sbjct: 419 IVTQWCEGSSLYKHLHVQETKFQMFQL---IDIARQTAQGMDYLHAK---NIIHRDMKSN 472 Query: 197 NVLLENDFTAKVADFGLA--KEASEGIEHISTQVMGTFGYVAPEYAM---TGHLLVKSDV 361 N+ L T K+ DFGLA K G + + Q G+ ++APE +SDV Sbjct: 473 NIFLHEGLTVKIGDFGLATVKSRWSGSQQVE-QPTGSVLWMAPEVIRMQDNNPFSFQSDV 531 Query: 362 YSYGVVLLELLSGRKP 409 YSYG+VL EL++G P Sbjct: 532 YSYGIVLYELMTGELP 547
>RIPK3_HUMAN (Q9Y572) Receptor-interacting serine/threonine-protein kinase 3 (EC| 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) Length = 518 Score = 68.6 bits (166), Expect = 7e-12 Identities = 50/141 (35%), Positives = 75/141 (53%), Gaps = 3/141 (2%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 LV + + NGS+ L PL ++ LG + YLH D NP ++HRD K S Sbjct: 92 LVTKFMENGSLSGLLQSQCPRPWPLLCRLLKEVVLG----MFYLH-DQNPVLLHRDLKPS 146 Query: 197 NVLLENDFTAKVADFGLAK-EASEGIEHISTQVMGTFGYVAPEYAMTGH--LLVKSDVYS 367 NVL + + K+ADFGL+ + S + GT GY+APE + + SDVYS Sbjct: 147 NVLPDPELHVKLADFGLSTFQGGSQSGTGSGEPGGTLGYLAPELFVNVNRKASTASDVYS 206 Query: 368 YGVVLLELLSGRKPVDMTQPS 430 +G+++ +L+GR+ T+PS Sbjct: 207 FGILMWAVLAGREVELPTEPS 227
>SKH1_SCHPO (Q9Y884) MAP kinase kinase skh1/pek1 (EC 2.7.12.2)| Length = 363 Score = 68.6 bits (166), Expect = 7e-12 Identities = 41/109 (37%), Positives = 59/109 (54%) Frame = +2 Query: 110 KIALGAARGLAYLHEDANPHVIHRDFKASNVLLENDFTAKVADFGLAKEASEGIEHISTQ 289 KIA G GL+YLH+ +IHRD K SN+LL + K+ DFG++ E + ++ Sbjct: 185 KIAFGVLSGLSYLHDRK---IIHRDIKPSNILLTSKGQVKLCDFGVSGEL---VNSLAGT 238 Query: 290 VMGTFGYVAPEYAMTGHLLVKSDVYSYGVVLLELLSGRKPVDMTQPSGS 436 GT Y+APE G + SD++S G+ L+E+ R P P GS Sbjct: 239 FTGTSYYMAPERISGGSYTISSDIWSLGLTLMEVALNRFPF---PPEGS 284
>SPKA_SYNY3 (Q9FAB3) Serine/threonine-protein kinase A (EC 2.7.11.1)| Length = 521 Score = 68.6 bits (166), Expect = 7e-12 Identities = 46/121 (38%), Positives = 62/121 (51%), Gaps = 10/121 (8%) Frame = +2 Query: 80 YGPLDFDTRMKIALGAARGLAYLHE------DANPHVIHRDFKASNVLLENDFT----AK 229 Y PL + +KIA GL H+ +A P V+HRD K SNVLL D K Sbjct: 109 YRPLKVERFLKIARQICFGLDCAHKGIIYQGEACP-VVHRDIKPSNVLLVEDPALGELVK 167 Query: 230 VADFGLAKEASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYSYGVVLLELLSGRKP 409 + DFG+AK E + MGT Y +PE L +SD+YS GV++ E+L+G P Sbjct: 168 ILDFGIAKLVQAAEESKTQAFMGTLAYCSPEQMEGKELDSRSDIYSLGVMMYEMLTGEMP 227 Query: 410 V 412 + Sbjct: 228 L 228
>LRRK1_HUMAN (Q38SD2) Leucine-rich repeat serine/threonine-protein kinase 1 (EC| 2.7.11.1) Length = 2038 Score = 68.6 bits (166), Expect = 7e-12 Identities = 50/140 (35%), Positives = 75/140 (53%), Gaps = 8/140 (5%) Frame = +2 Query: 14 CLVFELVPNGSVESHL--HGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDF 187 C EL P S+ + L + D + PL KIA A GLAYLH+ ++I D Sbjct: 1354 CFALELAPLSSLNTVLSENARDSSFIPLGHMLTQKIAYQIASGLAYLHKK---NIIFCDL 1410 Query: 188 KASNVLL-----ENDFTAKVADFGLAKEA-SEGIEHISTQVMGTFGYVAPEYAMTGHLLV 349 K+ N+L+ + K++D+G+++++ EG + V GT GY APE Sbjct: 1411 KSDNILVWSLDVKEHINIKLSDYGISRQSFHEG----ALGVEGTPGYQAPEIRPRIVYDE 1466 Query: 350 KSDVYSYGVVLLELLSGRKP 409 K D++SYG+VL ELLSG++P Sbjct: 1467 KVDMFSYGMVLYELLSGQRP 1486
>LCK_HUMAN (P06239) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell-specific protein-tyrosine kinase) Length = 508 Score = 68.6 bits (166), Expect = 7e-12 Identities = 46/145 (31%), Positives = 76/145 (52%), Gaps = 2/145 (1%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 ++ E + NGS+ L I L + + +A A G+A++ E + IHRD +A+ Sbjct: 313 IITEYMENGSLVDFLKTPSGI--KLTINKLLDMAAQIAEGMAFIEER---NYIHRDLRAA 367 Query: 197 NVLLENDFTAKVADFGLAKEASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYSYGV 376 N+L+ + + K+ADFGLA+ + + APE G +KSDV+S+G+ Sbjct: 368 NILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGI 427 Query: 377 VLLELLS-GRKPV-DMTQPSGSENL 445 +L E+++ GR P MT P +NL Sbjct: 428 LLTEIVTHGRIPYPGMTNPEVIQNL 452
>LCK_AOTNA (Q5PXS1) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) Length = 508 Score = 68.6 bits (166), Expect = 7e-12 Identities = 46/145 (31%), Positives = 76/145 (52%), Gaps = 2/145 (1%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 ++ E + NGS+ L I L + + +A A G+A++ E + IHRD +A+ Sbjct: 313 IITEYMENGSLVDFLKTPSGI--KLTINKLLDMAAQIAEGMAFIEER---NYIHRDLRAA 367 Query: 197 NVLLENDFTAKVADFGLAKEASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYSYGV 376 N+L+ + + K+ADFGLA+ + + APE G +KSDV+S+G+ Sbjct: 368 NILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGI 427 Query: 377 VLLELLS-GRKPV-DMTQPSGSENL 445 +L E+++ GR P MT P +NL Sbjct: 428 LLTEIVTHGRIPYPGMTNPEVIQNL 452
>PKN2_MYXXA (P54736) Serine/threonine-protein kinase pkn2 (EC 2.7.11.1)| Length = 830 Score = 68.2 bits (165), Expect = 9e-12 Identities = 48/145 (33%), Positives = 73/145 (50%), Gaps = 7/145 (4%) Frame = +2 Query: 14 CLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKA 193 CLV E V S+ L GP+ + + A GLA +H+ +IHRD K Sbjct: 87 CLVMEFVEGESLYDVLTP-----GPMPPGRALPLLQQLAEGLAAIHDKG---IIHRDLKP 138 Query: 194 SNVLLENDFT---AKVADFGLAK----EASEGIEHISTQVMGTFGYVAPEYAMTGHLLVK 352 NV + A++ DFG+A+ +A+ + I V+GT Y++PE A+ + + Sbjct: 139 ENVFISKSARGEQARLLDFGIARLVEPDAASSVSQIGV-VLGTPEYLSPEQAVGAKVDTR 197 Query: 353 SDVYSYGVVLLELLSGRKPVDMTQP 427 SD+YS+GV+ +LSGR P D P Sbjct: 198 SDLYSFGVLTYRVLSGRLPFDGPLP 222
>AVR2A_SHEEP (Q28560) Activin receptor type 2A precursor (EC 2.7.11.30) (Activin| receptor type IIA) (ACTR-IIA) Length = 513 Score = 68.2 bits (165), Expect = 9e-12 Identities = 47/109 (43%), Positives = 62/109 (56%), Gaps = 14/109 (12%) Frame = +2 Query: 113 IALGAARGLAYLHEDA-------NPHVIHRDFKASNVLLENDFTAKVADFGLAKEASEGI 271 IA ARGLAYLHED P + HRD K+ NVLL+N+ TA +ADFGLA + G Sbjct: 292 IAETMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGK 351 Query: 272 EHISTQ-VMGTFGYVAPEYAMTGHL------LVKSDVYSYGVVLLELLS 397 T +GT Y+APE + G + ++ D+Y+ G+VL EL S Sbjct: 352 SAGDTHGQVGTRRYMAPE-VLEGAINFQRDAFLRIDMYAMGLVLWELAS 399
>AVR2A_RAT (P38444) Activin receptor type 2A precursor (EC 2.7.11.30) (Activin| receptor type IIA) (ACTR-IIA) Length = 513 Score = 68.2 bits (165), Expect = 9e-12 Identities = 47/109 (43%), Positives = 62/109 (56%), Gaps = 14/109 (12%) Frame = +2 Query: 113 IALGAARGLAYLHEDA-------NPHVIHRDFKASNVLLENDFTAKVADFGLAKEASEGI 271 IA ARGLAYLHED P + HRD K+ NVLL+N+ TA +ADFGLA + G Sbjct: 292 IAETMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGK 351 Query: 272 EHISTQ-VMGTFGYVAPEYAMTGHL------LVKSDVYSYGVVLLELLS 397 T +GT Y+APE + G + ++ D+Y+ G+VL EL S Sbjct: 352 SGGDTHGQVGTRRYMAPE-VLEGAINFQRDAFLRIDMYAMGLVLWELAS 399
>AVR2A_MOUSE (P27038) Activin receptor type 2A precursor (EC 2.7.11.30) (Activin| receptor type IIA) (ACTR-IIA) Length = 513 Score = 68.2 bits (165), Expect = 9e-12 Identities = 47/109 (43%), Positives = 62/109 (56%), Gaps = 14/109 (12%) Frame = +2 Query: 113 IALGAARGLAYLHEDA-------NPHVIHRDFKASNVLLENDFTAKVADFGLAKEASEGI 271 IA ARGLAYLHED P + HRD K+ NVLL+N+ TA +ADFGLA + G Sbjct: 292 IAETMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGK 351 Query: 272 EHISTQ-VMGTFGYVAPEYAMTGHL------LVKSDVYSYGVVLLELLS 397 T +GT Y+APE + G + ++ D+Y+ G+VL EL S Sbjct: 352 SAGDTHGQVGTRRYMAPE-VLEGAINFQRDAFLRIDMYAMGLVLWELAS 399
>AVR2A_HUMAN (P27037) Activin receptor type 2A precursor (EC 2.7.11.30) (Activin| receptor type IIA) (ACTR-IIA) (ACTRIIA) Length = 513 Score = 68.2 bits (165), Expect = 9e-12 Identities = 47/109 (43%), Positives = 62/109 (56%), Gaps = 14/109 (12%) Frame = +2 Query: 113 IALGAARGLAYLHEDA-------NPHVIHRDFKASNVLLENDFTAKVADFGLAKEASEGI 271 IA ARGLAYLHED P + HRD K+ NVLL+N+ TA +ADFGLA + G Sbjct: 292 IAETMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGK 351 Query: 272 EHISTQ-VMGTFGYVAPEYAMTGHL------LVKSDVYSYGVVLLELLS 397 T +GT Y+APE + G + ++ D+Y+ G+VL EL S Sbjct: 352 SAGDTHGQVGTRRYMAPE-VLEGAINFQRDAFLRIDMYAMGLVLWELAS 399
>AVR2A_BOVIN (Q28043) Activin receptor type 2A precursor (EC 2.7.11.30) (Activin| receptor type IIA) (ACTR-IIA) Length = 513 Score = 68.2 bits (165), Expect = 9e-12 Identities = 47/109 (43%), Positives = 62/109 (56%), Gaps = 14/109 (12%) Frame = +2 Query: 113 IALGAARGLAYLHEDA-------NPHVIHRDFKASNVLLENDFTAKVADFGLAKEASEGI 271 IA ARGLAYLHED P + HRD K+ NVLL+N+ TA +ADFGLA + G Sbjct: 292 IAETMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGK 351 Query: 272 EHISTQ-VMGTFGYVAPEYAMTGHL------LVKSDVYSYGVVLLELLS 397 T +GT Y+APE + G + ++ D+Y+ G+VL EL S Sbjct: 352 SAGDTHGQVGTRRYMAPE-VLEGAINFQRDAFLRIDMYAMGLVLWELAS 399
>RAF1_MOUSE (Q99N57) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 68.2 bits (165), Expect = 9e-12 Identities = 46/136 (33%), Positives = 69/136 (50%), Gaps = 5/136 (3%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 +V + S+ HLH + + + IA A+G+ YLH ++IHRD K++ Sbjct: 419 IVTQWCEGSSLYKHLHVQETKFQMFQL---IDIARQTAQGMDYLHAK---NIIHRDMKSN 472 Query: 197 NVLLENDFTAKVADFGLA--KEASEGIEHISTQVMGTFGYVAPEYAM---TGHLLVKSDV 361 N+ L T K+ DFGLA K G + + Q G+ ++APE +SDV Sbjct: 473 NIFLHEGLTVKIGDFGLATVKSRWSGSQQVE-QPTGSVLWMAPEVIRMQDDNPFSFQSDV 531 Query: 362 YSYGVVLLELLSGRKP 409 YSYG+VL EL++G P Sbjct: 532 YSYGIVLYELMAGELP 547
>TESK1_HUMAN (Q15569) Dual specificity testis-specific protein kinase 1 (EC| 2.7.12.1) (Testicular protein kinase 1) Length = 626 Score = 68.2 bits (165), Expect = 9e-12 Identities = 51/137 (37%), Positives = 75/137 (54%), Gaps = 7/137 (5%) Frame = +2 Query: 26 ELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKASNVL 205 E + G++E L + PL + R+ +AL ARGL YLH V HRD + N L Sbjct: 130 EYMNGGTLEQLLSSPE----PLSWPVRLHLALDIARGLRYLHSKG---VFHRDLTSKNCL 182 Query: 206 LEND---FTAKVADFGLAKEA---SEGIEHISTQVMGTFGYVAPEYAMTGHLL-VKSDVY 364 + + FTA V DFGLA++ EG V+G+ ++APE + G L K+DV+ Sbjct: 183 VRREDRGFTAVVGDFGLAEKIPVYREGARKEPLAVVGSPYWMAPE-VLRGELYDEKADVF 241 Query: 365 SYGVVLLELLSGRKPVD 415 ++G+VL EL++ R P D Sbjct: 242 AFGIVLCELIA-RVPAD 257
>RAF_MSV36 (P00532) Serine/threonine-protein kinase transforming protein raf| (EC 2.7.11.1) Length = 323 Score = 68.2 bits (165), Expect = 9e-12 Identities = 46/136 (33%), Positives = 69/136 (50%), Gaps = 5/136 (3%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 +V + S+ HLH + + + IA A+G+ YLH ++IHRD K++ Sbjct: 94 IVTQWCEGSSLYKHLHVQETKFQMFQL---IDIARQTAQGMDYLHAK---NIIHRDMKSN 147 Query: 197 NVLLENDFTAKVADFGLA--KEASEGIEHISTQVMGTFGYVAPEYAM---TGHLLVKSDV 361 N+ L T K+ DFGLA K G + + Q G+ ++APE +SDV Sbjct: 148 NIFLHEGLTVKIGDFGLATVKSRWSGSQQVE-QPTGSVLWMAPEVIRMQDDNPFSFQSDV 206 Query: 362 YSYGVVLLELLSGRKP 409 YSYG+VL EL++G P Sbjct: 207 YSYGIVLYELMAGELP 222
>MKK2_YEAST (P32491) MAP kinase kinase MKK2/SSP33 (EC 2.7.12.2)| Length = 506 Score = 68.2 bits (165), Expect = 9e-12 Identities = 42/102 (41%), Positives = 55/102 (53%) Frame = +2 Query: 110 KIALGAARGLAYLHEDANPHVIHRDFKASNVLLENDFTAKVADFGLAKEASEGIEHISTQ 289 KIA RGL+YLHE VIHRD K N+LL K+ DFG++ EA + ++ Sbjct: 321 KIAESVLRGLSYLHERK---VIHRDIKPQNILLNEKGEIKLCDFGVSGEA---VNSLAMT 374 Query: 290 VMGTFGYVAPEYAMTGHLLVKSDVYSYGVVLLELLSGRKPVD 415 GT Y+APE V DV+S G+ LLE+ GR P + Sbjct: 375 FTGTSFYMAPERIQGQPYSVTCDVWSLGLTLLEVAGGRFPFE 416
>MATK_HUMAN (P42679) Megakaryocyte-associated tyrosine-protein kinase (EC| 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase) Length = 507 Score = 67.8 bits (164), Expect = 1e-11 Identities = 41/102 (40%), Positives = 58/102 (56%), Gaps = 1/102 (0%) Frame = +2 Query: 107 MKIALGAARGLAYLHEDANPHVIHRDFKASNVLLENDFTAKVADFGLAKEASEGIEHIST 286 ++ +L A G+ YL + ++HRD A N+L+ D AKV+DFGLAK +G++ Sbjct: 330 LQFSLHVAEGMEYLE---SKKLVHRDLAARNILVSEDLVAKVSDFGLAKAERKGLDSSRL 386 Query: 287 QVMGTFGYVAPEYAMTGHLLVKSDVYSYGVVLLELLS-GRKP 409 V T APE G KSDV+S+GV+L E+ S GR P Sbjct: 387 PVKWT----APEALKHGKFTSKSDVWSFGVLLWEVFSYGRAP 424
>RIPK3_RAT (Q9Z2P5) Receptor-interacting serine/threonine-protein kinase 3 (EC| 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) (Homocysteine respondent protein HCYP2) Length = 478 Score = 67.8 bits (164), Expect = 1e-11 Identities = 51/134 (38%), Positives = 70/134 (52%), Gaps = 4/134 (2%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 LV + NGS+ L S PL ++ LG + YLH NP ++HRD K S Sbjct: 93 LVTGFMENGSLSGLLQPSCPRPWPLLCRLLEEVVLG----MCYLHS-LNPSLLHRDLKPS 147 Query: 197 NVLLENDFTAKVADFGLAK---EASEGIEHISTQVMGTFGYVAPEYA-MTGHLLVKSDVY 364 NVLL+ + AK+ADFGL+ + G S GT Y+APE G SDVY Sbjct: 148 NVLLDLELHAKLADFGLSTFQGGSQSGSGSGSRDSGGTLAYLAPELLDNDGKASKASDVY 207 Query: 365 SYGVVLLELLSGRK 406 S+GV++ +L+GR+ Sbjct: 208 SFGVLVWTVLAGRE 221
>DSOR1_DROME (Q24324) Dual specificity mitogen-activated protein kinase kinase| dSOR1 (EC 2.7.12.2) (Downstream of RAF) (MAPKK) Length = 396 Score = 67.8 bits (164), Expect = 1e-11 Identities = 35/101 (34%), Positives = 60/101 (59%) Frame = +2 Query: 110 KIALGAARGLAYLHEDANPHVIHRDFKASNVLLENDFTAKVADFGLAKEASEGIEHISTQ 289 +I L +GL+YL + N +IHRD K SN+L+ + K+ DFG++ + I+ ++ Sbjct: 187 RITLAVLKGLSYLRD--NHAIIHRDVKPSNILVNSSGEIKICDFGVSGQL---IDSMANS 241 Query: 290 VMGTFGYVAPEYAMTGHLLVKSDVYSYGVVLLELLSGRKPV 412 +GT Y++PE H V+SD++S G+ L+E+ G P+ Sbjct: 242 FVGTRSYMSPERLQGTHYSVQSDIWSLGLSLVEMAIGMYPI 282
>PKNA_MYCLE (P54743) Probable serine/threonine-protein kinase pknA (EC| 2.7.11.1) Length = 437 Score = 67.8 bits (164), Expect = 1e-11 Identities = 47/135 (34%), Positives = 64/135 (47%) Frame = +2 Query: 5 RTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRD 184 RT LV ELV + S L K G L + + R L H ++HRD Sbjct: 89 RTAYLVMELVNGEPLNSVL----KRTGRLSLRHALDMLEQTGRALQIAHAAG---LVHRD 141 Query: 185 FKASNVLLENDFTAKVADFGLAKEASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVY 364 K N+L+ K+ DFG+AK + VMGT Y+APE A+ SDVY Sbjct: 142 VKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQALGHDATPASDVY 201 Query: 365 SYGVVLLELLSGRKP 409 S GV+ E++SG++P Sbjct: 202 SLGVIGYEVVSGKRP 216
>PKNB_BIFLO (Q8G6P9) Probable serine/threonine-protein kinase pknB (EC| 2.7.11.1) Length = 690 Score = 67.4 bits (163), Expect = 2e-11 Identities = 40/114 (35%), Positives = 60/114 (52%), Gaps = 2/114 (1%) Frame = +2 Query: 74 KIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKASNVLLENDFTAKVADFGLAK 253 K+ G L ++ LG L Y H +IHRD K N+++ KV DFG+A+ Sbjct: 113 KVNGALSQRDCEQVMLGVLNALDYSHRMG---IIHRDIKPGNIMISEQGVVKVMDFGIAR 169 Query: 254 EASEGIEHI--STQVMGTFGYVAPEYAMTGHLLVKSDVYSYGVVLLELLSGRKP 409 + + S V+GT Y++PE A + ++SD+YS G VL E+L+GR P Sbjct: 170 ALDDSAATMTQSQGVVGTAQYLSPEQARGETVDMRSDLYSAGCVLYEMLTGRPP 223
>FYN_XENLA (P13406) Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2)| (p59-Fyn) Length = 536 Score = 67.4 bits (163), Expect = 2e-11 Identities = 43/132 (32%), Positives = 69/132 (52%), Gaps = 1/132 (0%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 +V E + GS+ L + L + +A ARG+AY+ + IHRD +++ Sbjct: 339 IVTEYMSKGSLLDFLKDGEG--RALKLPNLVDMAAQVARGMAYIER---MNYIHRDLRSA 393 Query: 197 NVLLENDFTAKVADFGLAKEASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYSYGV 376 N+L+ N K+ADFGLA+ + + APE A+ G +KSDV+S+G+ Sbjct: 394 NILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGI 453 Query: 377 VLLELLS-GRKP 409 +L EL++ GR P Sbjct: 454 LLTELVTKGRVP 465
>PTK6_HUMAN (Q13882) Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor| kinase) (Tyrosine-protein kinase BRK) Length = 451 Score = 67.4 bits (163), Expect = 2e-11 Identities = 44/127 (34%), Positives = 67/127 (52%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 ++ EL+ GS+ L SD+ P+ + IA A G+ YL + IHRD A Sbjct: 262 IITELMAKGSLLELLRDSDEKVLPVS--ELLDIAWQVAEGMCYLESQ---NYIHRDLAAR 316 Query: 197 NVLLENDFTAKVADFGLAKEASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYSYGV 376 N+L+ + KV DFGLA+ E + ++S + + APE GH KSDV+S+G+ Sbjct: 317 NILVGENTLCKVGDFGLARLIKEDV-YLSHDHNIPYKWTAPEALSRGHYSTKSDVWSFGI 375 Query: 377 VLLELLS 397 +L E+ S Sbjct: 376 LLHEMFS 382
>AVR2A_XENLA (P27039) Activin receptor type 2A precursor (EC 2.7.11.30) (Activin| receptor type II) (ACTR-II) Length = 514 Score = 67.4 bits (163), Expect = 2e-11 Identities = 46/109 (42%), Positives = 63/109 (57%), Gaps = 14/109 (12%) Frame = +2 Query: 113 IALGAARGLAYLHEDA-------NPHVIHRDFKASNVLLENDFTAKVADFGLAKEASEGI 271 IA ARGL++LHED P V HRD K+ NVLL+N+ TA +ADFGLA + G Sbjct: 293 IAETMARGLSHLHEDIPGLKDGHKPAVAHRDIKSKNVLLKNNLTACIADFGLALKFEAGK 352 Query: 272 EHISTQ-VMGTFGYVAPEYAMTGHL------LVKSDVYSYGVVLLELLS 397 T +GT Y+APE + G + ++ D+Y++G+VL EL S Sbjct: 353 SAGDTHGQVGTRRYMAPE-VLEGAINFQRDAFLRIDMYAFGLVLWELAS 400
>MATK_RAT (P41243) Megakaryocyte-associated tyrosine-protein kinase (EC| 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase BATK) Length = 467 Score = 67.4 bits (163), Expect = 2e-11 Identities = 43/103 (41%), Positives = 59/103 (57%), Gaps = 2/103 (1%) Frame = +2 Query: 107 MKIALGAARGLAYLHEDANPHVIHRDFKASNVLLENDFTAKVADFGLAK-EASEGIEHIS 283 ++ AL A G+ YL + ++HRD A N+L+ D AKV+DFGLAK E +G++ Sbjct: 289 LQFALHVAEGMEYLE---SKKLVHRDLAARNILVSEDLVAKVSDFGLAKAELRKGLDSSR 345 Query: 284 TQVMGTFGYVAPEYAMTGHLLVKSDVYSYGVVLLELLS-GRKP 409 V T APE G KSDV+S+GV+L E+ S GR P Sbjct: 346 LPVKWT----APEALKNGRFSSKSDVWSFGVLLWEVFSYGRAP 384
>SRC_RSVPA (P31693) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 522 Score = 67.4 bits (163), Expect = 2e-11 Identities = 44/132 (33%), Positives = 69/132 (52%), Gaps = 1/132 (0%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 +V E + GS+ L G Y L +++A A G+AY+ + +HRD +A+ Sbjct: 332 IVIEYMSKGSLLDFLKGEMGKY--LRLPQLVEMAAQIASGMAYVER---MNYVHRDLRAA 386 Query: 197 NVLLENDFTAKVADFGLAKEASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYSYGV 376 N+L+ + KVADFGLA+ + + APE A+ G +KSDV+S+G+ Sbjct: 387 NILVGENLVCKVADFGLARLIEDNEYTARPGARFPVKWTAPEAALYGRFTIKSDVWSFGI 446 Query: 377 VLLELLS-GRKP 409 +L EL + GR P Sbjct: 447 LLTELTTKGRVP 458
>PKNX_STRCO (Q9XA16) Probable serine/threonine-protein kinase SCO3848 (EC| 2.7.11.1) Length = 673 Score = 67.0 bits (162), Expect = 2e-11 Identities = 43/133 (32%), Positives = 70/133 (52%), Gaps = 2/133 (1%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 +V E V ++ LH K+ + +++ +G + L Y H ++HRD K + Sbjct: 90 IVMEYVDGSTLRELLHSGRKLLP----ERTLEMTIGILQALEYSHRAG---IVHRDIKPA 142 Query: 197 NVLLENDFTAKVADFGLAKEASE-GIEHISTQ-VMGTFGYVAPEYAMTGHLLVKSDVYSY 370 NV+L + KV DFG+A+ + G+ T V+GT Y++PE A + +SD+YS Sbjct: 143 NVMLTRNGQVKVMDFGIARAMGDSGMTMTQTAAVIGTAQYLSPEQAKGEQVDARSDLYST 202 Query: 371 GVVLLELLSGRKP 409 G +L ELL+ R P Sbjct: 203 GCLLYELLTVRPP 215
>SRC1_XENLA (P13115) Tyrosine-protein kinase Src-1 (EC 2.7.10.2) (p60-Src-1)| Length = 531 Score = 67.0 bits (162), Expect = 2e-11 Identities = 44/132 (33%), Positives = 68/132 (51%), Gaps = 1/132 (0%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 +V E + GS+ L G Y L + +A A G+AY+ + +HRD +A+ Sbjct: 334 IVTEYISKGSLLDFLKGEMGRY--LRLPQLVDMAAQIASGMAYVER---MNYVHRDLRAA 388 Query: 197 NVLLENDFTAKVADFGLAKEASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYSYGV 376 N+L+ + KVADFGLA+ + + APE A+ G +KSDV+S+G+ Sbjct: 389 NILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGI 448 Query: 377 VLLELLS-GRKP 409 +L EL + GR P Sbjct: 449 LLTELTTKGRVP 460
>PKNA_MYCTU (P65726) Probable serine/threonine-protein kinase pknA (EC| 2.7.11.1) Length = 431 Score = 67.0 bits (162), Expect = 2e-11 Identities = 48/135 (35%), Positives = 63/135 (46%) Frame = +2 Query: 5 RTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRD 184 RT LV ELV + S L K G L + + R L H ++HRD Sbjct: 89 RTAYLVMELVNGEPLNSVL----KRTGRLSLRHALDMLEQTGRALQIAHAAG---LVHRD 141 Query: 185 FKASNVLLENDFTAKVADFGLAKEASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVY 364 K N+L+ K+ DFG+AK + VMGT Y+APE A+ SDVY Sbjct: 142 VKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQALGHDASPASDVY 201 Query: 365 SYGVVLLELLSGRKP 409 S GVV E +SG++P Sbjct: 202 SLGVVGYEAVSGKRP 216
>PKNA_MYCBO (P65727) Probable serine/threonine-protein kinase pknA (EC| 2.7.11.1) Length = 431 Score = 67.0 bits (162), Expect = 2e-11 Identities = 48/135 (35%), Positives = 63/135 (46%) Frame = +2 Query: 5 RTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRD 184 RT LV ELV + S L K G L + + R L H ++HRD Sbjct: 89 RTAYLVMELVNGEPLNSVL----KRTGRLSLRHALDMLEQTGRALQIAHAAG---LVHRD 141 Query: 185 FKASNVLLENDFTAKVADFGLAKEASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVY 364 K N+L+ K+ DFG+AK + VMGT Y+APE A+ SDVY Sbjct: 142 VKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQALGHDASPASDVY 201 Query: 365 SYGVVLLELLSGRKP 409 S GVV E +SG++P Sbjct: 202 SLGVVGYEAVSGKRP 216
>SRC_RSVSE (P63185) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 67.0 bits (162), Expect = 2e-11 Identities = 44/132 (33%), Positives = 68/132 (51%), Gaps = 1/132 (0%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 +V E + GS+ L G Y L + +A A G+AY+ + +HRD +A+ Sbjct: 335 IVIEYMSKGSLLDFLKGEMGKY--LRLPQLVDMAAQIASGMAYVER---MNYVHRDLRAA 389 Query: 197 NVLLENDFTAKVADFGLAKEASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYSYGV 376 N+L+ + KVADFGLA+ + + APE A+ G +KSDV+S+G+ Sbjct: 390 NILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGI 449 Query: 377 VLLELLS-GRKP 409 +L EL + GR P Sbjct: 450 LLTELTTKGRVP 461
>SRC_RSVP (P00526) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 67.0 bits (162), Expect = 2e-11 Identities = 44/132 (33%), Positives = 68/132 (51%), Gaps = 1/132 (0%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 +V E + GS+ L G Y L + +A A G+AY+ + +HRD +A+ Sbjct: 335 IVIEYMSKGSLLDFLKGEMGKY--LRLPQLVDMAAQIASGMAYVER---MNYVHRDLRAA 389 Query: 197 NVLLENDFTAKVADFGLAKEASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYSYGV 376 N+L+ + KVADFGLA+ + + APE A+ G +KSDV+S+G+ Sbjct: 390 NILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGI 449 Query: 377 VLLELLS-GRKP 409 +L EL + GR P Sbjct: 450 LLTELTTKGRVP 461
>SRC_RSVH1 (P25020) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 67.0 bits (162), Expect = 2e-11 Identities = 44/132 (33%), Positives = 68/132 (51%), Gaps = 1/132 (0%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 +V E + GS+ L G Y L + +A A G+AY+ + +HRD +A+ Sbjct: 335 IVIEYMSKGSLLDFLKGEMGKY--LRLPQLVDMAAQIASGMAYVER---MNYVHRDLRAA 389 Query: 197 NVLLENDFTAKVADFGLAKEASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYSYGV 376 N+L+ + KVADFGLA+ + + APE A+ G +KSDV+S+G+ Sbjct: 390 NILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGI 449 Query: 377 VLLELLS-GRKP 409 +L EL + GR P Sbjct: 450 LLTELTTKGRVP 461
>PKNB_MYCTU (P0A5S4) Probable serine/threonine-protein kinase pknB (EC| 2.7.11.1) Length = 626 Score = 67.0 bits (162), Expect = 2e-11 Identities = 41/139 (29%), Positives = 71/139 (51%), Gaps = 2/139 (1%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 +V E V ++ +H GP+ +++ A + L + H++ +IHRD K + Sbjct: 90 IVMEYVDGVTLRDIVHTE----GPMTPKRAIEVIADACQALNFSHQNG---IIHRDVKPA 142 Query: 197 NVLLENDFTAKVADFGLAKEASEGIEHIS--TQVMGTFGYVAPEYAMTGHLLVKSDVYSY 370 N+++ KV DFG+A+ ++ ++ V+GT Y++PE A + +SDVYS Sbjct: 143 NIMISATNAVKVMDFGIARAIADSGNSVTQTAAVIGTAQYLSPEQARGDSVDARSDVYSL 202 Query: 371 GVVLLELLSGRKPVDMTQP 427 G VL E+L+G P P Sbjct: 203 GCVLYEVLTGEPPFTGDSP 221
>PKNB_MYCBO (P0A5S5) Probable serine/threonine-protein kinase pknB (EC| 2.7.11.1) Length = 626 Score = 67.0 bits (162), Expect = 2e-11 Identities = 41/139 (29%), Positives = 71/139 (51%), Gaps = 2/139 (1%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 +V E V ++ +H GP+ +++ A + L + H++ +IHRD K + Sbjct: 90 IVMEYVDGVTLRDIVHTE----GPMTPKRAIEVIADACQALNFSHQNG---IIHRDVKPA 142 Query: 197 NVLLENDFTAKVADFGLAKEASEGIEHIS--TQVMGTFGYVAPEYAMTGHLLVKSDVYSY 370 N+++ KV DFG+A+ ++ ++ V+GT Y++PE A + +SDVYS Sbjct: 143 NIMISATNAVKVMDFGIARAIADSGNSVTQTAAVIGTAQYLSPEQARGDSVDARSDVYSL 202 Query: 371 GVVLLELLSGRKPVDMTQP 427 G VL E+L+G P P Sbjct: 203 GCVLYEVLTGEPPFTGDSP 221
>SRC_HUMAN (P12931) Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2)| (p60-Src) (c-Src) (pp60c-src) Length = 535 Score = 67.0 bits (162), Expect = 2e-11 Identities = 44/132 (33%), Positives = 68/132 (51%), Gaps = 1/132 (0%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 +V E + GS+ L G Y L + +A A G+AY+ + +HRD +A+ Sbjct: 338 IVTEYMSKGSLLDFLKGETGKY--LRLPQLVDMAAQIASGMAYVER---MNYVHRDLRAA 392 Query: 197 NVLLENDFTAKVADFGLAKEASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYSYGV 376 N+L+ + KVADFGLA+ + + APE A+ G +KSDV+S+G+ Sbjct: 393 NILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGI 452 Query: 377 VLLELLS-GRKP 409 +L EL + GR P Sbjct: 453 LLTELTTKGRVP 464
>LCK_SAISC (Q95KR7) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) Length = 508 Score = 67.0 bits (162), Expect = 2e-11 Identities = 45/145 (31%), Positives = 75/145 (51%), Gaps = 2/145 (1%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 ++ E + NGS+ L I L + + +A G+A+L E + IHRD +A+ Sbjct: 313 IITEYMENGSLVDFLKTPSGI--KLTINKLLDMAAQIVEGMAFLEER---NYIHRDLRAA 367 Query: 197 NVLLENDFTAKVADFGLAKEASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYSYGV 376 N+L+ + + K+ADFGLA+ + + APE G +KSDV+S+G+ Sbjct: 368 NILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGI 427 Query: 377 VLLELLS-GRKPV-DMTQPSGSENL 445 ++ E+++ GR P MT P +NL Sbjct: 428 LMTEIVTHGRIPYPGMTNPEVIQNL 452
>MP2K1_XENLA (Q05116) Dual specificity mitogen-activated protein kinase kinase 1| (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1) Length = 394 Score = 66.6 bits (161), Expect = 3e-11 Identities = 34/101 (33%), Positives = 60/101 (59%) Frame = +2 Query: 110 KIALGAARGLAYLHEDANPHVIHRDFKASNVLLENDFTAKVADFGLAKEASEGIEHISTQ 289 K+++ +GL YL E ++HRD K SN+L+ + K+ DFG++ + I+ ++ Sbjct: 167 KVSIAVIKGLTYLREKHK--IMHRDVKPSNILVNSRGEIKLCDFGVSGQL---IDSMANS 221 Query: 290 VMGTFGYVAPEYAMTGHLLVKSDVYSYGVVLLELLSGRKPV 412 +GT Y++PE H V+SD++S G+ L+E+ GR P+ Sbjct: 222 FVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAIGRYPI 262
>M3K7_DROME (Q9V3Q6) Mitogen-activated protein kinase kinase kinase 7 (EC| 2.7.11.25) (TGF-beta-activated kinase 1) (dTAK1) Length = 678 Score = 66.6 bits (161), Expect = 3e-11 Identities = 45/132 (34%), Positives = 64/132 (48%), Gaps = 1/132 (0%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 L+ E GS+ + LHG K+ M A A GLAYLH +IHRD K Sbjct: 87 LIMEFAEGGSLHNFLHG--KVKPAYSLAHAMSWARQCAEGLAYLHAMTPKPLIHRDVKPL 144 Query: 197 NVLLEN-DFTAKVADFGLAKEASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYSYG 373 N+LL N K+ DFG + S + T G+ ++APE K D++S+ Sbjct: 145 NLLLTNKGRNLKICDFGTVADKST----MMTNNRGSAAWMAPEVFEGSKYTEKCDIFSWA 200 Query: 374 VVLLELLSGRKP 409 +VL E+LS ++P Sbjct: 201 IVLWEVLSRKQP 212
>STE7_YEAST (P06784) Serine/threonine-protein kinase STE7 (EC 2.7.12.2)| Length = 515 Score = 66.6 bits (161), Expect = 3e-11 Identities = 38/104 (36%), Positives = 60/104 (57%) Frame = +2 Query: 101 TRMKIALGAARGLAYLHEDANPHVIHRDFKASNVLLENDFTAKVADFGLAKEASEGIEHI 280 T KIA G GL +L+ +IHRD K SNVL+ + K+ DFG++K+ I I Sbjct: 306 TISKIAYGVLNGLDHLYRQYK--IIHRDIKPSNVLINSKGQIKLCDFGVSKKL---INSI 360 Query: 281 STQVMGTFGYVAPEYAMTGHLLVKSDVYSYGVVLLELLSGRKPV 412 + +GT Y++PE +K DV+S G++++EL++G P+ Sbjct: 361 ADTFVGTSTYMSPERIQGNVYSIKGDVWSLGLMIIELVTGEFPL 404
>CSK_CHICK (P41239) Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase)| Length = 450 Score = 66.6 bits (161), Expect = 3e-11 Identities = 51/134 (38%), Positives = 70/134 (52%), Gaps = 3/134 (2%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 +V E + GS+ +L + L D +K +L + YL +AN + +HRD A Sbjct: 264 IVTEYMAKGSLVDYLRSRGR--SVLGGDCLLKFSLDVCEAMEYL--EAN-NFVHRDLAAR 318 Query: 197 NVLLENDFTAKVADFGLAKEASEGIEHISTQVMGTF--GYVAPEYAMTGHLLVKSDVYSY 370 NVL+ D AKV+DFGL KEAS STQ G + APE KSDV+S+ Sbjct: 319 NVLVSEDNIAKVSDFGLTKEAS------STQDTGKLPVKWTAPEALREKKFSTKSDVWSF 372 Query: 371 GVVLLELLS-GRKP 409 G++L E+ S GR P Sbjct: 373 GILLWEIYSFGRVP 386
>SRC64_DROME (P00528) Tyrosine-protein kinase Src64B (EC 2.7.10.2) (Dsrc64)| Length = 552 Score = 66.6 bits (161), Expect = 3e-11 Identities = 44/127 (34%), Positives = 66/127 (51%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 +V E + GS+ L D Y L F+ + IA A G+ YL + +IHRD A Sbjct: 354 IVQEYMSKGSLLDFLREGDGRY--LHFEDLIYIATQVASGMEYLE---SKQLIHRDLAAR 408 Query: 197 NVLLENDFTAKVADFGLAKEASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYSYGV 376 NVL+ + AK+ DFGLA+ ++ + APE + G +KSDV+SYG+ Sbjct: 409 NVLIGENNVAKICDFGLARVIADDEYCPKQGSRFPVKWTAPEAIIYGKFSIKSDVWSYGI 468 Query: 377 VLLELLS 397 +L+EL + Sbjct: 469 LLMELFT 475
>JAK1_HUMAN (P23458) Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1)| (JAK-1) Length = 1142 Score = 66.6 bits (161), Expect = 3e-11 Identities = 43/130 (33%), Positives = 69/130 (53%), Gaps = 3/130 (2%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 L+ E +P+GS++ +L K ++ ++K A+ +G+ YL + +HRD A Sbjct: 942 LIMEFLPSGSLKEYL---PKNKNKINLKQQLKYAVQICKGMDYL---GSRQYVHRDLAAR 995 Query: 197 NVLLENDFTAKVADFGLAKEASEGIEHIST---QVMGTFGYVAPEYAMTGHLLVKSDVYS 367 NVL+E++ K+ DFGL K E+ + + F Y APE M + SDV+S Sbjct: 996 NVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWY-APECLMQSKFYIASDVWS 1054 Query: 368 YGVVLLELLS 397 +GV L ELL+ Sbjct: 1055 FGVTLHELLT 1064
>RK_MOUSE (Q9WVL4) Rhodopsin kinase precursor (EC 2.7.11.14) (RK) (G| protein-coupled receptor kinase 1) Length = 564 Score = 66.6 bits (161), Expect = 3e-11 Identities = 40/132 (30%), Positives = 65/132 (49%) Frame = +2 Query: 14 CLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKA 193 CLV ++ G V H++ D+ + GL +LH+ +++RD K Sbjct: 264 CLVMTIMNGGDVRYHIYNVDEDNPGFSEPRAIYYTAQIISGLEHLHQR---RIVYRDLKP 320 Query: 194 SNVLLENDFTAKVADFGLAKEASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYSYG 373 NVLL+ND +++D GLA E EG ++ + GT G++APE D ++ G Sbjct: 321 ENVLLDNDGNIRISDLGLAVELKEG-QNKTKGYAGTPGFMAPELLRGEEYDFSVDYFALG 379 Query: 374 VVLLELLSGRKP 409 V L E+++ R P Sbjct: 380 VTLYEMIAARGP 391
>MP2K1_SERCA (Q91447) Dual specificity mitogen-activated protein kinase kinase 1| (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1) (Fragment) Length = 388 Score = 66.6 bits (161), Expect = 3e-11 Identities = 34/101 (33%), Positives = 60/101 (59%) Frame = +2 Query: 110 KIALGAARGLAYLHEDANPHVIHRDFKASNVLLENDFTAKVADFGLAKEASEGIEHISTQ 289 K+++ +GL YL E ++HRD K SN+L+ + K+ DFG++ + I+ ++ Sbjct: 161 KVSIAVIKGLTYLREKHK--IMHRDVKPSNILVNSRGEIKLCDFGVSGQL---IDSMANS 215 Query: 290 VMGTFGYVAPEYAMTGHLLVKSDVYSYGVVLLELLSGRKPV 412 +GT Y++PE H V+SD++S G+ L+E+ GR P+ Sbjct: 216 FVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAIGRYPI 256
>MP2K1_CRIGR (Q63980) Dual specificity mitogen-activated protein kinase kinase 1| (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1) Length = 393 Score = 66.6 bits (161), Expect = 3e-11 Identities = 34/101 (33%), Positives = 60/101 (59%) Frame = +2 Query: 110 KIALGAARGLAYLHEDANPHVIHRDFKASNVLLENDFTAKVADFGLAKEASEGIEHISTQ 289 K+++ +GL YL E ++HRD K SN+L+ + K+ DFG++ + I+ ++ Sbjct: 168 KVSIAVIKGLTYLREKHK--IMHRDVKPSNILVNSRGEIKLCDFGVSGQL---IDSMANS 222 Query: 290 VMGTFGYVAPEYAMTGHLLVKSDVYSYGVVLLELLSGRKPV 412 +GT Y++PE H V+SD++S G+ L+E+ GR P+ Sbjct: 223 FVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPI 263
>MP2K1_RAT (Q01986) Dual specificity mitogen-activated protein kinase kinase 1| (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1) Length = 392 Score = 66.6 bits (161), Expect = 3e-11 Identities = 34/101 (33%), Positives = 60/101 (59%) Frame = +2 Query: 110 KIALGAARGLAYLHEDANPHVIHRDFKASNVLLENDFTAKVADFGLAKEASEGIEHISTQ 289 K+++ +GL YL E ++HRD K SN+L+ + K+ DFG++ + I+ ++ Sbjct: 167 KVSIAVIKGLTYLREKHK--IMHRDVKPSNILVNSRGEIKLCDFGVSGQL---IDSMANS 221 Query: 290 VMGTFGYVAPEYAMTGHLLVKSDVYSYGVVLLELLSGRKPV 412 +GT Y++PE H V+SD++S G+ L+E+ GR P+ Sbjct: 222 FVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPI 262
>MP2K1_RABIT (P29678) Dual specificity mitogen-activated protein kinase kinase 1| (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1) Length = 392 Score = 66.6 bits (161), Expect = 3e-11 Identities = 34/101 (33%), Positives = 60/101 (59%) Frame = +2 Query: 110 KIALGAARGLAYLHEDANPHVIHRDFKASNVLLENDFTAKVADFGLAKEASEGIEHISTQ 289 K+++ +GL YL E ++HRD K SN+L+ + K+ DFG++ + I+ ++ Sbjct: 167 KVSIAVIKGLTYLREKHK--IMHRDVKPSNILVNSRGEIKLCDFGVSGQL---IDSMANS 221 Query: 290 VMGTFGYVAPEYAMTGHLLVKSDVYSYGVVLLELLSGRKPV 412 +GT Y++PE H V+SD++S G+ L+E+ GR P+ Sbjct: 222 FVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPI 262
>MP2K1_MOUSE (P31938) Dual specificity mitogen-activated protein kinase kinase 1| (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1) Length = 392 Score = 66.6 bits (161), Expect = 3e-11 Identities = 34/101 (33%), Positives = 60/101 (59%) Frame = +2 Query: 110 KIALGAARGLAYLHEDANPHVIHRDFKASNVLLENDFTAKVADFGLAKEASEGIEHISTQ 289 K+++ +GL YL E ++HRD K SN+L+ + K+ DFG++ + I+ ++ Sbjct: 167 KVSIAVIKGLTYLREKHK--IMHRDVKPSNILVNSRGEIKLCDFGVSGQL---IDSMANS 221 Query: 290 VMGTFGYVAPEYAMTGHLLVKSDVYSYGVVLLELLSGRKPV 412 +GT Y++PE H V+SD++S G+ L+E+ GR P+ Sbjct: 222 FVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPI 262
>MP2K1_HUMAN (Q02750) Dual specificity mitogen-activated protein kinase kinase 1| (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1) Length = 392 Score = 66.6 bits (161), Expect = 3e-11 Identities = 34/101 (33%), Positives = 60/101 (59%) Frame = +2 Query: 110 KIALGAARGLAYLHEDANPHVIHRDFKASNVLLENDFTAKVADFGLAKEASEGIEHISTQ 289 K+++ +GL YL E ++HRD K SN+L+ + K+ DFG++ + I+ ++ Sbjct: 167 KVSIAVIKGLTYLREKHK--IMHRDVKPSNILVNSRGEIKLCDFGVSGQL---IDSMANS 221 Query: 290 VMGTFGYVAPEYAMTGHLLVKSDVYSYGVVLLELLSGRKPV 412 +GT Y++PE H V+SD++S G+ L+E+ GR P+ Sbjct: 222 FVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPI 262
>SRC2_XENLA (P13116) Tyrosine-protein kinase Src-2 (EC 2.7.10.2) (p60-Src-2)| Length = 531 Score = 66.2 bits (160), Expect = 3e-11 Identities = 44/132 (33%), Positives = 68/132 (51%), Gaps = 1/132 (0%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 +V E + GS+ L G Y L + +A A G+AY+ + +HRD +A+ Sbjct: 334 IVTEYMSKGSLLDFLKGEMGRY--LRLPQLVDMAAQIASGMAYVER---MNYVHRDLRAA 388 Query: 197 NVLLENDFTAKVADFGLAKEASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYSYGV 376 N+L+ + KVADFGLA+ + + APE A+ G +KSDV+S+G+ Sbjct: 389 NILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGI 448 Query: 377 VLLELLS-GRKP 409 +L EL + GR P Sbjct: 449 LLTELTTKGRVP 460
>SRC_AVIST (P14085) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 556 Score = 66.2 bits (160), Expect = 3e-11 Identities = 44/132 (33%), Positives = 68/132 (51%), Gaps = 1/132 (0%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 +V E + GS+ L G Y L + +A A G+AY+ + +HRD +A+ Sbjct: 335 IVTEYMSKGSLLDFLKGEMGKY--LRLPQLVDMAAQIASGMAYVER---MNYVHRDLRAA 389 Query: 197 NVLLENDFTAKVADFGLAKEASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYSYGV 376 N+L+ + KVADFGLA+ + + APE A+ G +KSDV+S+G+ Sbjct: 390 NILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGI 449 Query: 377 VLLELLS-GRKP 409 +L EL + GR P Sbjct: 450 LLTELTTKGRVP 461
>SRC_RSVSA (P00524) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 66.2 bits (160), Expect = 3e-11 Identities = 44/132 (33%), Positives = 68/132 (51%), Gaps = 1/132 (0%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 +V E + GS+ L G Y L + +A A G+AY+ + +HRD +A+ Sbjct: 335 IVTEYMSKGSLLDFLKGEMGKY--LRLPQLVDMAAQIASGMAYVER---MNYVHRDLRAA 389 Query: 197 NVLLENDFTAKVADFGLAKEASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYSYGV 376 N+L+ + KVADFGLA+ + + APE A+ G +KSDV+S+G+ Sbjct: 390 NILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGI 449 Query: 377 VLLELLS-GRKP 409 +L EL + GR P Sbjct: 450 LLTELTTKGRVP 461
>SRC_AVISR (P00525) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 66.2 bits (160), Expect = 3e-11 Identities = 44/132 (33%), Positives = 68/132 (51%), Gaps = 1/132 (0%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 +V E + GS+ L G Y L + +A A G+AY+ + +HRD +A+ Sbjct: 335 IVTEYMSKGSLLDFLKGEMGKY--LRLPQLVDMAAQIASGMAYVER---MNYVHRDLRAA 389 Query: 197 NVLLENDFTAKVADFGLAKEASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYSYGV 376 N+L+ + KVADFGLA+ + + APE A+ G +KSDV+S+G+ Sbjct: 390 NILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGI 449 Query: 377 VLLELLS-GRKP 409 +L EL + GR P Sbjct: 450 LLTELTTKGRVP 461
>FGR_FSVGR (P00544) Tyrosine-protein kinase transforming protein Fgr (EC| 2.7.10.2) Length = 545 Score = 66.2 bits (160), Expect = 3e-11 Identities = 44/132 (33%), Positives = 69/132 (52%), Gaps = 1/132 (0%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 +V E + +GS+ L D+ L + +A A G+AY+ IHRD +A+ Sbjct: 355 IVTEFMCHGSLLEFL--KDQEGQDLTLPQLVDMAAQVAEGMAYMER---MDYIHRDLRAA 409 Query: 197 NVLLENDFTAKVADFGLAKEASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYSYGV 376 N+L+ K+ADFGLA+ + + + APE A+ G +KSDV+S+G+ Sbjct: 410 NILVGERLVCKIADFGLARLIEDNEYNPRQGAKFPIKWTAPEAALFGRFTIKSDVWSFGI 469 Query: 377 VLLELLS-GRKP 409 +L EL+S GR P Sbjct: 470 LLTELISKGRVP 481
>SRC_AVIS2 (P15054) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 586 Score = 66.2 bits (160), Expect = 3e-11 Identities = 44/132 (33%), Positives = 68/132 (51%), Gaps = 1/132 (0%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 +V E + GS+ L G Y L + +A A G+AY+ + +HRD +A+ Sbjct: 335 IVTEYMSKGSLLDFLKGEMGKY--LRLPQLVDMAAQIASGMAYVER---MNYVHRDLRAA 389 Query: 197 NVLLENDFTAKVADFGLAKEASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYSYGV 376 N+L+ + KVADFGLA+ + + APE A+ G +KSDV+S+G+ Sbjct: 390 NILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGI 449 Query: 377 VLLELLS-GRKP 409 +L EL + GR P Sbjct: 450 LLTELTTKGRVP 461
>CLA4_YEAST (P48562) Serine/threonine-protein kinase CLA4 (EC 2.7.11.1)| Length = 842 Score = 66.2 bits (160), Expect = 3e-11 Identities = 43/134 (32%), Positives = 65/134 (48%), Gaps = 3/134 (2%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGS---DKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDF 187 +V E + GS+ + S D + PL I +GL +LH+ H+IHRD Sbjct: 638 VVMEFMEGGSLTDIIENSPTNDNSHSPLTEPQIAYIVRETCQGLKFLHDK---HIIHRDI 694 Query: 188 KASNVLLENDFTAKVADFGLAKEASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYS 367 K+ NVLL+ K+ DFG ++ +T V GT ++APE K DV+S Sbjct: 695 KSDNVLLDTRARVKITDFGFCARLTDKRSKRATMV-GTPYWMAPEVVKQREYDEKIDVWS 753 Query: 368 YGVVLLELLSGRKP 409 G++ +E+L G P Sbjct: 754 LGIMTIEMLEGEPP 767
>SRMS_MOUSE (Q62270) Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70)| Length = 496 Score = 66.2 bits (160), Expect = 3e-11 Identities = 44/127 (34%), Positives = 68/127 (53%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 +V EL+ G+++ +L S+ L + A A G++YL E V+HRD A Sbjct: 304 IVTELMGKGNLQVYLGSSEG--KALSLPHLLGFACQVAEGMSYLEER---RVVHRDLAAR 358 Query: 197 NVLLENDFTAKVADFGLAKEASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYSYGV 376 NVL+ +D T KVADFGLA+ + + S+ + APE A KSDV+S+G+ Sbjct: 359 NVLVGDDLTCKVADFGLARLLKDDVYSPSSGSKIPVKWTAPEAANYRVFSQKSDVWSFGI 418 Query: 377 VLLELLS 397 +L E+ + Sbjct: 419 LLYEVFT 425
>TESK1_RAT (Q63572) Dual specificity testis-specific protein kinase 1 (EC| 2.7.12.1) (Testicular protein kinase 1) Length = 628 Score = 66.2 bits (160), Expect = 3e-11 Identities = 50/137 (36%), Positives = 75/137 (54%), Gaps = 7/137 (5%) Frame = +2 Query: 26 ELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKASNVL 205 E + G++E L + PL + R+ +AL A+GL YLH V HRD + N L Sbjct: 125 EYMNGGTLEQLLSSPE----PLSWPVRLHLALDIAQGLRYLHAKG---VFHRDLTSKNCL 177 Query: 206 LEND---FTAKVADFGLAKEAS---EGIEHISTQVMGTFGYVAPEYAMTGHLL-VKSDVY 364 + + FTA V DFGLA++ EG V+G+ ++APE + G L K+DV+ Sbjct: 178 VRREDGGFTAVVGDFGLAEKIPVYREGARKEPLAVVGSPYWMAPE-VLRGELYDEKADVF 236 Query: 365 SYGVVLLELLSGRKPVD 415 ++G+VL EL++ R P D Sbjct: 237 AFGIVLCELIA-RVPAD 252
>SRC42_DROME (Q9V9J3) Tyrosine-protein kinase Src42A (EC 2.7.10.2) (Dsrc41)| Length = 517 Score = 66.2 bits (160), Expect = 3e-11 Identities = 45/132 (34%), Positives = 67/132 (50%), Gaps = 1/132 (0%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 ++ EL+ +GS+ +L L T + +A A G+AYL + IHRD A Sbjct: 318 IITELMKHGSLLEYLQAIAGKGRSLKMQTLIDMAAQIAAGMAYLESQ---NYIHRDLAAR 374 Query: 197 NVLLENDFTAKVADFGLAKEASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYSYGV 376 NVL+ + K+ADFGLA+ E + APE A +KSDV+S+G+ Sbjct: 375 NVLVGDGNIVKIADFGLARLIKEDEYEARVGARFPIKWTAPEAANYSKFSIKSDVWSFGI 434 Query: 377 VLLELLS-GRKP 409 +L EL++ GR P Sbjct: 435 LLTELVTYGRIP 446
>CSK_RAT (P32577) Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase)| Length = 450 Score = 66.2 bits (160), Expect = 3e-11 Identities = 49/134 (36%), Positives = 68/134 (50%), Gaps = 3/134 (2%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 +V E + GS+ +L + L D +K +L + YL + + +HRD A Sbjct: 264 IVTEYMAKGSLVDYLRSRGR--SVLGGDCLLKFSLDVCEAMEYLEGN---NFVHRDLAAR 318 Query: 197 NVLLENDFTAKVADFGLAKEASEGIEHISTQVMGTF--GYVAPEYAMTGHLLVKSDVYSY 370 NVL+ D AKV+DFGL KEAS STQ G + APE KSDV+S+ Sbjct: 319 NVLVSEDNVAKVSDFGLTKEAS------STQDTGKLPVKWTAPEALREKKFSTKSDVWSF 372 Query: 371 GVVLLELLS-GRKP 409 G++L E+ S GR P Sbjct: 373 GILLWEIYSFGRVP 386
>CSK_HUMAN (P41240) Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase)| (Protein-tyrosine kinase CYL) Length = 450 Score = 66.2 bits (160), Expect = 3e-11 Identities = 49/134 (36%), Positives = 68/134 (50%), Gaps = 3/134 (2%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 +V E + GS+ +L + L D +K +L + YL + + +HRD A Sbjct: 264 IVTEYMAKGSLVDYLRSRGR--SVLGGDCLLKFSLDVCEAMEYLEGN---NFVHRDLAAR 318 Query: 197 NVLLENDFTAKVADFGLAKEASEGIEHISTQVMGTF--GYVAPEYAMTGHLLVKSDVYSY 370 NVL+ D AKV+DFGL KEAS STQ G + APE KSDV+S+ Sbjct: 319 NVLVSEDNVAKVSDFGLTKEAS------STQDTGKLPVKWTAPEALREKKFSTKSDVWSF 372 Query: 371 GVVLLELLS-GRKP 409 G++L E+ S GR P Sbjct: 373 GILLWEIYSFGRVP 386
>CLA4_ASHGO (Q9HFW2) Serine/threonine-protein kinase CLA4 (EC 2.7.11.1)| Length = 793 Score = 66.2 bits (160), Expect = 3e-11 Identities = 44/140 (31%), Positives = 68/140 (48%), Gaps = 3/140 (2%) Frame = +2 Query: 17 LVFELVPNGSVESHLH---GSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDF 187 +V E + GS+ + GSD P+ I +GL +LH+ H+IHRD Sbjct: 589 VVMEYMEGGSLTDVIENSIGSDASESPMTEPQIAYIVRETCQGLKFLHDK---HIIHRDI 645 Query: 188 KASNVLLENDFTAKVADFGLAKEASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYS 367 K+ NVLL+ K+ DFG + ++ +T V GT ++APE K DV+S Sbjct: 646 KSDNVLLDTHGRVKITDFGFCAKLTDKRSKRATMV-GTPYWMAPEVVKQREYDEKVDVWS 704 Query: 368 YGVVLLELLSGRKPVDMTQP 427 G++ +E+L G P +P Sbjct: 705 LGIMTIEMLEGEPPYLNEEP 724
>SRC_AVISS (P14084) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 567 Score = 66.2 bits (160), Expect = 3e-11 Identities = 44/132 (33%), Positives = 68/132 (51%), Gaps = 1/132 (0%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 +V E + GS+ L G Y L + +A A G+AY+ + +HRD +A+ Sbjct: 335 IVTEYMSKGSLLDFLKGEMGKY--LRLPQLVDMAAQIASGMAYVER---MNYVHRDLRAA 389 Query: 197 NVLLENDFTAKVADFGLAKEASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYSYGV 376 N+L+ + KVADFGLA+ + + APE A+ G +KSDV+S+G+ Sbjct: 390 NILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGI 449 Query: 377 VLLELLS-GRKP 409 +L EL + GR P Sbjct: 450 LLTELTTKGRVP 461
>RK_RAT (Q63651) Rhodopsin kinase precursor (EC 2.7.11.14) (RK) (G| protein-coupled receptor kinase 1) Length = 564 Score = 66.2 bits (160), Expect = 3e-11 Identities = 40/132 (30%), Positives = 65/132 (49%) Frame = +2 Query: 14 CLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKA 193 CLV ++ G V H++ D+ + GL +LH+ +++RD K Sbjct: 264 CLVMTIMNGGDVRYHIYNVDEENPGFPEPRAIYYTAQIISGLEHLHQR---RIVYRDLKP 320 Query: 194 SNVLLENDFTAKVADFGLAKEASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYSYG 373 NVLL+ND +++D GLA E EG ++ + GT G++APE D ++ G Sbjct: 321 ENVLLDNDGNIRISDLGLAVELKEG-QNKTKGYAGTPGFMAPELLRGEEYDFSVDYFALG 379 Query: 374 VVLLELLSGRKP 409 V L E+++ R P Sbjct: 380 VTLYEMIAARGP 391
>SRC_CHICK (P00523) Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2)| (p60-Src) (c-Src) (pp60c-src) Length = 532 Score = 66.2 bits (160), Expect = 3e-11 Identities = 44/132 (33%), Positives = 68/132 (51%), Gaps = 1/132 (0%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 +V E + GS+ L G Y L + +A A G+AY+ + +HRD +A+ Sbjct: 335 IVTEYMSKGSLLDFLKGEMGKY--LRLPQLVDMAAQIASGMAYVER---MNYVHRDLRAA 389 Query: 197 NVLLENDFTAKVADFGLAKEASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYSYGV 376 N+L+ + KVADFGLA+ + + APE A+ G +KSDV+S+G+ Sbjct: 390 NILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGI 449 Query: 377 VLLELLS-GRKP 409 +L EL + GR P Sbjct: 450 LLTELTTKGRVP 461
>TESK1_MOUSE (O70146) Dual specificity testis-specific protein kinase 1 (EC| 2.7.12.1) (Testicular protein kinase 1) Length = 627 Score = 66.2 bits (160), Expect = 3e-11 Identities = 50/137 (36%), Positives = 75/137 (54%), Gaps = 7/137 (5%) Frame = +2 Query: 26 ELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKASNVL 205 E + G++E L + PL + R+ +AL A+GL YLH V HRD + N L Sbjct: 125 EYMNGGTLEQLLSSPE----PLSWPVRLHLALDIAQGLRYLHAKG---VFHRDLTSKNCL 177 Query: 206 LEND---FTAKVADFGLAKEAS---EGIEHISTQVMGTFGYVAPEYAMTGHLL-VKSDVY 364 + + FTA V DFGLA++ EG V+G+ ++APE + G L K+DV+ Sbjct: 178 VRREDRGFTAVVGDFGLAEKIPVYREGTRKEPLAVVGSPYWMAPE-VLRGELYDEKADVF 236 Query: 365 SYGVVLLELLSGRKPVD 415 ++G+VL EL++ R P D Sbjct: 237 AFGIVLCELIA-RVPAD 252
>TESK2_RAT (Q924U5) Dual specificity testis-specific protein kinase 2 (EC| 2.7.12.1) (Testicular protein kinase 2) Length = 570 Score = 65.9 bits (159), Expect = 4e-11 Identities = 47/130 (36%), Positives = 77/130 (59%), Gaps = 6/130 (4%) Frame = +2 Query: 26 ELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKASNVL 205 E + +G++E L + +Y P + R+K+A A GL+YLH + HRD + N L Sbjct: 131 EYINSGNLEQLLDSN--LYLP--WTVRVKLAYDIAVGLSYLHFKG---IFHRDLTSKNCL 183 Query: 206 L---ENDFTAKVADFGLAK---EASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYS 367 + EN ++A VADFGLA+ +AS G E ++ V+G+ ++APE K+DV+S Sbjct: 184 IKRDENGYSAVVADFGLAEKIPDASIGSEKLA--VVGSPFWMAPEVLRDEPYNEKADVFS 241 Query: 368 YGVVLLELLS 397 YG++L E+++ Sbjct: 242 YGIILCEIIA 251
>FYN_CHICK (Q05876) Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2)| (p59-Fyn) Length = 533 Score = 65.9 bits (159), Expect = 4e-11 Identities = 44/137 (32%), Positives = 70/137 (51%), Gaps = 1/137 (0%) Frame = +2 Query: 2 RRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHR 181 RR +V E + GS+ L + L + +A A G+AY+ + IHR Sbjct: 331 RRPIYIVTEYMSKGSLLIFLKDGEG--RALKLPNLVDMAAQVAAGMAYIER---MNYIHR 385 Query: 182 DFKASNVLLENDFTAKVADFGLAKEASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDV 361 D +++N+L+ N K+ADFGLA+ + + APE A+ G +KSDV Sbjct: 386 DLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDV 445 Query: 362 YSYGVVLLELLS-GRKP 409 +S+G++L EL++ GR P Sbjct: 446 WSFGILLTELVTKGRVP 462
>LCK_CHICK (P42683) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (Protein-tyrosine kinase C-TKL) (p56tk1) Length = 507 Score = 65.9 bits (159), Expect = 4e-11 Identities = 45/145 (31%), Positives = 74/145 (51%), Gaps = 2/145 (1%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 ++ E + GS+ L S+ I L + + +A A G+A++ + IHRD +A+ Sbjct: 312 IITEYMEKGSLVDFLKTSEGI--KLSINKLLDMAAQIAEGMAFIEAK---NYIHRDLRAA 366 Query: 197 NVLLENDFTAKVADFGLAKEASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYSYGV 376 N+L+ K+ADFGLA+ + + APE G +KSDV+S+G+ Sbjct: 367 NILVSEALCCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGI 426 Query: 377 VLLELLS-GRKPV-DMTQPSGSENL 445 +L E+++ GR P MT P +NL Sbjct: 427 LLTEIVTYGRIPYPGMTNPEVIQNL 451
>GPRK2_DROME (P32866) G protein-coupled receptor kinase 2 (EC 2.7.11.16)| Length = 714 Score = 65.9 bits (159), Expect = 4e-11 Identities = 42/135 (31%), Positives = 70/135 (51%) Frame = +2 Query: 14 CLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKA 193 CLV ++ G ++ H++ G + + A A GL +LH+ +++RD K Sbjct: 383 CLVLTIMNGGDLKFHIYNMGGEPG-FELERARFYAAEVACGLQHLHKQG---IVYRDCKP 438 Query: 194 SNVLLENDFTAKVADFGLAKEASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYSYG 373 N+LL++ +++D GLA E EG E + +V GT GY+APE D +S+G Sbjct: 439 ENILLDDHGHVRISDLGLAVEIPEG-EMVRGRV-GTVGYMAPEVIDNEKYAFSPDWFSFG 496 Query: 374 VVLLELLSGRKPVDM 418 +L E++ G+ P M Sbjct: 497 CLLYEMIEGQAPFRM 511
>CSK_MOUSE (P41241) Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase)| (Protein-tyrosine kinase MPK-2) (p50CSK) Length = 450 Score = 65.9 bits (159), Expect = 4e-11 Identities = 49/134 (36%), Positives = 68/134 (50%), Gaps = 3/134 (2%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 +V E + GS+ +L + L D +K +L + YL + + +HRD A Sbjct: 264 IVTEYMAKGSLVDYLRSRGR--SVLGGDCLLKFSLDVLEAMEYLEGN---NFVHRDLAAR 318 Query: 197 NVLLENDFTAKVADFGLAKEASEGIEHISTQVMGTF--GYVAPEYAMTGHLLVKSDVYSY 370 NVL+ D AKV+DFGL KEAS STQ G + APE KSDV+S+ Sbjct: 319 NVLVSEDNVAKVSDFGLTKEAS------STQDTGKLPVKWTAPEALREKKFSTKSDVWSF 372 Query: 371 GVVLLELLS-GRKP 409 G++L E+ S GR P Sbjct: 373 GILLWEIYSFGRVP 386
>YES_HUMAN (P07947) Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2)| (p61-Yes) (c-Yes) Length = 542 Score = 65.9 bits (159), Expect = 4e-11 Identities = 43/132 (32%), Positives = 68/132 (51%), Gaps = 1/132 (0%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 +V E + GS+ L D Y L + +A A G+AY+ + IHRD +A+ Sbjct: 345 IVTEFMSKGSLLDFLKEGDGKY--LKLPQLVDMAAQIADGMAYIER---MNYIHRDLRAA 399 Query: 197 NVLLENDFTAKVADFGLAKEASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYSYGV 376 N+L+ + K+ADFGLA+ + + APE A+ G +KSDV+S+G+ Sbjct: 400 NILVGENLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGI 459 Query: 377 VLLELLS-GRKP 409 + EL++ GR P Sbjct: 460 LQTELVTKGRVP 471
>SRK2_SPOLA (P42688) Tyrosine-protein kinase SRK2 (EC 2.7.10.2) (Fragment)| Length = 362 Score = 65.9 bits (159), Expect = 4e-11 Identities = 44/132 (33%), Positives = 70/132 (53%), Gaps = 1/132 (0%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 ++ EL+ GS+ +L G G L + +A A G+AYL + IHRD A Sbjct: 165 IITELMSKGSLLDYLQGEA---GALKLPQLIDMAAQVAAGMAYLELH---NYIHRDLAAR 218 Query: 197 NVLLENDFTAKVADFGLAKEASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYSYGV 376 N+L+ ++ KVADFGLA+ + + + APE A+ +KSDV+S+G+ Sbjct: 219 NILVGDNNICKVADFGLARLIVSDDYNATEGAKFPIKWTAPEAALFNRFSIKSDVWSFGI 278 Query: 377 VLLELLS-GRKP 409 ++ EL++ GR P Sbjct: 279 LITELVTYGRIP 290
>YES_XENLA (P10936) Tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes)| Length = 536 Score = 65.5 bits (158), Expect = 6e-11 Identities = 43/132 (32%), Positives = 70/132 (53%), Gaps = 1/132 (0%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 +V E + GS+ L + Y L + +A A G+AY+ + IHRD +A+ Sbjct: 339 IVTEYMIKGSLLDFLKEGNGKY--LKLPQLVDMAAQIADGMAYIER---MNYIHRDLRAA 393 Query: 197 NVLLENDFTAKVADFGLAKEASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYSYGV 376 N+L+ ++ K+ADFGLA+ + + APE A+ G +KSDV+S+G+ Sbjct: 394 NILVGDNLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGI 453 Query: 377 VLLELLS-GRKP 409 +L EL++ GR P Sbjct: 454 LLTELVAKGRVP 465
>PLK4_MOUSE (Q64702) Serine/threonine-protein kinase PLK4 (EC 2.7.11.21)| (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine-protein kinase 18) Length = 925 Score = 65.5 bits (158), Expect = 6e-11 Identities = 44/133 (33%), Positives = 66/133 (49%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 LV E+ NG + +L K + + M + G+ YLH ++HRD S Sbjct: 87 LVLEMCHNGEMNRYLKNRMKPFSEREARHFMHQII---TGMLYLHSHG---ILHRDLTLS 140 Query: 197 NVLLENDFTAKVADFGLAKEASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYSYGV 376 N+LL + K+ADFGLA + + E T + GT Y++PE A ++SD++S G Sbjct: 141 NILLTRNMNIKIADFGLATQLNMPHEKHYT-LCGTPNYISPEIATRSAHGLESDIWSLGC 199 Query: 377 VLLELLSGRKPVD 415 + LL GR P D Sbjct: 200 MFYTLLIGRPPFD 212
>JAK1_CYPCA (Q09178) Tyrosine-protein kinase Jak1 (EC 2.7.10.2) (Janus kinase 1)| (Jak-1) Length = 1156 Score = 65.5 bits (158), Expect = 6e-11 Identities = 43/129 (33%), Positives = 69/129 (53%), Gaps = 2/129 (1%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 L+ E +P GS++ +L + +D T + A+ +G+ L A+ + IHRD A Sbjct: 954 LIMEFLPAGSLKEYLPRNK---AHIDLKTLLNYAVQICQGMDLL---ASRNYIHRDLAAR 1007 Query: 197 NVLLENDFTAKVADFGLAK--EASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYSY 370 NVL+EN+ T K+ DFGL K + +EG + + + APE + SDV+S+ Sbjct: 1008 NVLVENENTVKIGDFGLTKSIKDNEGYYTVKDDLDSPVFWYAPECLIHCKFYRASDVWSF 1067 Query: 371 GVVLLELLS 397 GV + ELL+ Sbjct: 1068 GVTMYELLT 1076
>YES_MOUSE (Q04736) Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2)| (p61-Yes) (c-Yes) Length = 540 Score = 65.5 bits (158), Expect = 6e-11 Identities = 43/132 (32%), Positives = 68/132 (51%), Gaps = 1/132 (0%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 +V E + GS+ L D Y L + +A A G+AY+ + IHRD +A+ Sbjct: 343 IVTEFMSKGSLLDFLKEGDGKY--LKLPQLVDMAAQIADGMAYIER---MNYIHRDLRAA 397 Query: 197 NVLLENDFTAKVADFGLAKEASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYSYGV 376 N+L+ + K+ADFGLA+ + + APE A+ G +KSDV+S+G+ Sbjct: 398 NILVGENLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGI 457 Query: 377 VLLELLS-GRKP 409 + EL++ GR P Sbjct: 458 LQTELVTKGRVP 469
>YES_CHICK (P09324) Tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes)| Length = 540 Score = 65.5 bits (158), Expect = 6e-11 Identities = 42/132 (31%), Positives = 70/132 (53%), Gaps = 1/132 (0%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 +V E + GS+ L + + L + +A A G+AY+ + IHRD +A+ Sbjct: 343 IVTEFMTKGSLLDFLKEGEGKF--LKLPQLVDMAAQIADGMAYIER---MNYIHRDLRAA 397 Query: 197 NVLLENDFTAKVADFGLAKEASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYSYGV 376 N+L+ ++ K+ADFGLA+ + + APE A+ G +KSDV+S+G+ Sbjct: 398 NILVGDNLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGI 457 Query: 377 VLLELLS-GRKP 409 +L EL++ GR P Sbjct: 458 LLTELVTKGRVP 469
>SRC_MOUSE (P05480) Neuronal proto-oncogene tyrosine-protein kinase Src (EC| 2.7.10.2) (p60-Src) (c-Src) (pp60c-src) Length = 540 Score = 65.5 bits (158), Expect = 6e-11 Identities = 43/132 (32%), Positives = 68/132 (51%), Gaps = 1/132 (0%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 +V E + GS+ L G Y L + ++ A G+AY+ + +HRD +A+ Sbjct: 343 IVTEYMNKGSLLDFLKGETGKY--LRLPQLVDMSAQIASGMAYVER---MNYVHRDLRAA 397 Query: 197 NVLLENDFTAKVADFGLAKEASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYSYGV 376 N+L+ + KVADFGLA+ + + APE A+ G +KSDV+S+G+ Sbjct: 398 NILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGI 457 Query: 377 VLLELLS-GRKP 409 +L EL + GR P Sbjct: 458 LLTELTTKGRVP 469
>PKWA_THECU (P49695) Probable serine/threonine-protein kinase pkwA (EC| 2.7.11.1) Length = 742 Score = 65.5 bits (158), Expect = 6e-11 Identities = 40/109 (36%), Positives = 57/109 (52%) Frame = +2 Query: 83 GPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKASNVLLENDFTAKVADFGLAKEAS 262 GPL + +A G GLA +H ++HRDFK SN++L D +V DFG+A+ Sbjct: 108 GPLYGNNLRTLAAGLVEGLAAIHACG---LVHRDFKPSNIVLAAD-GPRVIDFGVARPLD 163 Query: 263 EGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYSYGVVLLELLSGRKP 409 + S V+GT Y++PE + SDV+S G VL +GR P Sbjct: 164 SSVMTQSGAVIGTLAYMSPEQTDGSQVGPASDVFSLGTVLAFAATGRSP 212
>KRAF1_DROME (P11346) Raf homolog serine/threonine-protein kinase dRAF-1 (EC| 2.7.11.1) (Protein pole-hole) Length = 739 Score = 65.5 bits (158), Expect = 6e-11 Identities = 42/131 (32%), Positives = 70/131 (53%), Gaps = 4/131 (3%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 +V + S+ H+H S+ + +T + I A+G+ YLH ++IHRD K++ Sbjct: 499 IVTQWCEGSSLYKHVHVSETKF---KLNTLIDIGRQVAQGMDYLHAK---NIIHRDLKSN 552 Query: 197 NVLLENDFTAKVADFGLAKEASE-GIEHISTQVMGTFGYVAPEYAMTGHL---LVKSDVY 364 N+ L D + K+ DFGLA + E + Q G+ ++APE L +SDVY Sbjct: 553 NIFLHEDLSVKIGDFGLATAKTRWSGEKQANQPTGSILWMAPEVIRMQELNPYSFQSDVY 612 Query: 365 SYGVVLLELLS 397 ++G+V+ ELL+ Sbjct: 613 AFGIVMYELLA 623
>YES_AVISY (P00527) Tyrosine-protein kinase transforming protein YES (EC| 2.7.10.2) (Fragment) Length = 528 Score = 65.5 bits (158), Expect = 6e-11 Identities = 42/132 (31%), Positives = 70/132 (53%), Gaps = 1/132 (0%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 +V E + GS+ L + + L + +A A G+AY+ + IHRD +A+ Sbjct: 336 IVTEFMTKGSLLDFLKEGEGKF--LKLPQLVDMAAQIADGMAYIER---MNYIHRDLRAA 390 Query: 197 NVLLENDFTAKVADFGLAKEASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYSYGV 376 N+L+ ++ K+ADFGLA+ + + APE A+ G +KSDV+S+G+ Sbjct: 391 NILVGDNLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGI 450 Query: 377 VLLELLS-GRKP 409 +L EL++ GR P Sbjct: 451 LLTELVTKGRVP 462
>YES_CANFA (Q28923) Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2)| (p61-Yes) (c-Yes) Length = 538 Score = 65.1 bits (157), Expect = 8e-11 Identities = 43/132 (32%), Positives = 67/132 (50%), Gaps = 1/132 (0%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 +V E + GS+ L D Y L + +A A G+AY+ + IHRD +A+ Sbjct: 341 IVTEFMSKGSLLDFLKEGDGKY--LKLPQLVDMAAQIADGMAYIER---MNYIHRDLRAA 395 Query: 197 NVLLENDFTAKVADFGLAKEASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYSYGV 376 N+L+ + K+ADFGLA+ + + APE A+ G +KSDV+S+G+ Sbjct: 396 NILVGENLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGI 455 Query: 377 VLLELLS-GRKP 409 + EL + GR P Sbjct: 456 LQTELTTKGRVP 467
>TLK1_CAEEL (P34314) Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1)| (Tousled-like kinase 1) Length = 965 Score = 65.1 bits (157), Expect = 8e-11 Identities = 50/151 (33%), Positives = 80/151 (52%), Gaps = 14/151 (9%) Frame = +2 Query: 14 CLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKA 193 C V E VP ++ +L + I + + R I + L YL+E + P +IH D K Sbjct: 730 CTVLEYVPGNDLDFYLKQNRSIS---EKEAR-SIIMQVVSALVYLNEKSTP-IIHYDLKP 784 Query: 194 SNVLLENDFTA---KVADFGLAK-------EASEGIEHISTQVMGTFGYVAPEYAMTG-- 337 +N+LLE+ T+ K+ DFGL+K + GIE +++Q GT+ Y+ PE + Sbjct: 785 ANILLESGNTSGAIKITDFGLSKIMEGESDDHDLGIE-LTSQFAGTYWYLPPETFIVPPP 843 Query: 338 HLLVKSDVYSYGVVLLELLSGRKPV--DMTQ 424 + K DV+S GV+ + + G+KP D+TQ Sbjct: 844 KITCKVDVWSIGVIFYQCIYGKKPFGNDLTQ 874
>PKN1_COREF (Q8FUI5) Probable serine/threonine protein kinase CE0033 (EC| 2.7.11.1) Length = 660 Score = 65.1 bits (157), Expect = 8e-11 Identities = 43/134 (32%), Positives = 64/134 (47%), Gaps = 7/134 (5%) Frame = +2 Query: 47 VESHLHGSD-----KIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKASNVLLE 211 V +HG D + GP I + L HE +IHRD K +N+++ Sbjct: 89 VMERVHGRDLRDIVREDGPYSPSQAATIMIPVCHALQSSHEAG---IIHRDVKPANIMIN 145 Query: 212 NDFTAKVADFGLAKEASEGIEHIS--TQVMGTFGYVAPEYAMTGHLLVKSDVYSYGVVLL 385 N KV DFG+A+ + ++ V+GT Y++PE A +SDVY+ G VL Sbjct: 146 NTGGVKVMDFGIARALDDSTSAMTQTAAVIGTAQYLSPEQARGKPADARSDVYAAGCVLY 205 Query: 386 ELLSGRKPVDMTQP 427 EL++GR P + P Sbjct: 206 ELVTGRPPFEGESP 219
>ANKK1_HUMAN (Q8NFD2) Ankyrin repeat and protein kinase domain-containing| protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (X-kinase) (SgK288) Length = 765 Score = 65.1 bits (157), Expect = 8e-11 Identities = 43/136 (31%), Positives = 72/136 (52%), Gaps = 5/136 (3%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 +V E + NGS+E L L + R +I + + +LH P ++H D K Sbjct: 96 IVMEFMANGSLEKVLSTHS-----LCWKLRFRIIHETSLAMNFLHS-IKPPLLHLDLKPG 149 Query: 197 NVLLENDFTAKVADFGLAK--EASEGIEHISTQVM-GTFGYVAPEYAMTGHLL--VKSDV 361 N+LL+++ K++DFGL+K E S +++I + G Y+ PE + + K DV Sbjct: 150 NILLDSNMHVKISDFGLSKWMEQSTRMQYIERSALRGMLSYIPPEMFLESNKAPGPKYDV 209 Query: 362 YSYGVVLLELLSGRKP 409 YS+ +V+ ELL+ +KP Sbjct: 210 YSFAIVIWELLTQKKP 225
>PLK4_HUMAN (O00444) Serine/threonine-protein kinase PLK4 (EC 2.7.11.21)| (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine-protein kinase 18) Length = 970 Score = 65.1 bits (157), Expect = 8e-11 Identities = 45/133 (33%), Positives = 63/133 (47%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 LV E+ NG + +L K P + G+ YLH ++HRD S Sbjct: 87 LVLEMCHNGEMNRYLKNRVK---PFSENEARHFMHQIITGMLYLHSHG---ILHRDLTLS 140 Query: 197 NVLLENDFTAKVADFGLAKEASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYSYGV 376 N+LL + K+ADFGLA + E T + GT Y++PE A ++SDV+S G Sbjct: 141 NLLLTRNMNIKIADFGLATQLKMPHEKHYT-LCGTPNYISPEIATRSAHGLESDVWSLGC 199 Query: 377 VLLELLSGRKPVD 415 + LL GR P D Sbjct: 200 MFYTLLIGRPPFD 212
>SRC_RAT (Q9WUD9) Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2)| (p60-Src) (c-Src) (pp60c-src) Length = 535 Score = 65.1 bits (157), Expect = 8e-11 Identities = 43/132 (32%), Positives = 68/132 (51%), Gaps = 1/132 (0%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 +V E + GS+ L G Y L + ++ A G+AY+ + +HRD +A+ Sbjct: 338 IVTEYMNKGSLLDFLKGETGKY--LRLPQLVDMSAQIASGMAYVDR---MNYVHRDLRAA 392 Query: 197 NVLLENDFTAKVADFGLAKEASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYSYGV 376 N+L+ + KVADFGLA+ + + APE A+ G +KSDV+S+G+ Sbjct: 393 NILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGI 452 Query: 377 VLLELLS-GRKP 409 +L EL + GR P Sbjct: 453 LLTELTTKGRVP 464
>TESK2_MOUSE (Q8VCT9) Dual specificity testis-specific protein kinase 2 (EC| 2.7.12.1) (Testicular protein kinase 2) Length = 570 Score = 65.1 bits (157), Expect = 8e-11 Identities = 47/130 (36%), Positives = 76/130 (58%), Gaps = 6/130 (4%) Frame = +2 Query: 26 ELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKASNVL 205 E + +G++E L +Y P + R+K+A A GL+YLH + HRD + N L Sbjct: 131 EYINSGNLEQLLDSD--LYLP--WTVRVKLAYDIAVGLSYLHFKG---IFHRDLTSKNCL 183 Query: 206 L---ENDFTAKVADFGLAK---EASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYS 367 + EN ++A VADFGLA+ +AS G E ++ V+G+ ++APE K+DV+S Sbjct: 184 IKRDENGYSAVVADFGLAEKIPDASIGREKLA--VVGSPFWMAPEVLRDEPYNEKADVFS 241 Query: 368 YGVVLLELLS 397 YG++L E+++ Sbjct: 242 YGIILCEIIA 251
>FYN_MOUSE (P39688) Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2)| (p59-Fyn) Length = 533 Score = 65.1 bits (157), Expect = 8e-11 Identities = 42/132 (31%), Positives = 68/132 (51%), Gaps = 1/132 (0%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 +V E + GS+ L + L + +A A G+AY+ + IHRD +++ Sbjct: 336 IVTEYMSKGSLLDFLKDGEG--RALKLPNLVDMAAQVAAGMAYIER---MNYIHRDLRSA 390 Query: 197 NVLLENDFTAKVADFGLAKEASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYSYGV 376 N+L+ N K+ADFGLA+ + + APE A+ G +KSDV+S+G+ Sbjct: 391 NILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGI 450 Query: 377 VLLELLS-GRKP 409 +L EL++ GR P Sbjct: 451 LLTELVTKGRVP 462
>YES_XIPHE (P27447) Tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes)| Length = 543 Score = 64.7 bits (156), Expect = 1e-10 Identities = 42/132 (31%), Positives = 70/132 (53%), Gaps = 1/132 (0%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 +V E + GS+ L D + L + +A A G+A++ + IHRD +A+ Sbjct: 346 IVTEFMGKGSLLDFLKEGDGKH--LKLPQLVDMASQIADGMAFIER---MNYIHRDLRAA 400 Query: 197 NVLLENDFTAKVADFGLAKEASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYSYGV 376 N+L+ ++ K+ADFGLA+ + + APE A+ G +KSDV+S+G+ Sbjct: 401 NILVADNLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGI 460 Query: 377 VLLELLS-GRKP 409 +L EL++ GR P Sbjct: 461 LLTELVTKGRVP 472
>SRK3_SPOLA (P42689) Tyrosine-protein kinase SRK3 (EC 2.7.10.2) (Fragment)| Length = 334 Score = 64.7 bits (156), Expect = 1e-10 Identities = 45/133 (33%), Positives = 69/133 (51%), Gaps = 2/133 (1%) Frame = +2 Query: 17 LVFELVPNGSVESHL-HGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKA 193 +V EL+ GS+ +L HG K + + ++ A G+ YL + IHRD A Sbjct: 136 IVTELMKYGSMLEYLKHGEGK---NITLHQMVDMSAQIASGMTYLEAHS---YIHRDLAA 189 Query: 194 SNVLLENDFTAKVADFGLAKEASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYSYG 373 N+L+ KVADFGLA+ E I + + APE A+ +KSDV+S+G Sbjct: 190 RNILVGEGNVCKVADFGLARVIKEDIYNPREGTKFPIKWTAPEAALYNRFTIKSDVWSFG 249 Query: 374 VVLLELLS-GRKP 409 V++ E+++ GR P Sbjct: 250 VLISEIVTHGRMP 262
>FYN_HUMAN (P06241) Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2)| (p59-Fyn) (Protooncogene Syn) (SLK) Length = 536 Score = 64.7 bits (156), Expect = 1e-10 Identities = 36/100 (36%), Positives = 57/100 (57%), Gaps = 1/100 (1%) Frame = +2 Query: 113 IALGAARGLAYLHEDANPHVIHRDFKASNVLLENDFTAKVADFGLAKEASEGIEHISTQV 292 +A A G+AY+ + IHRD +++N+L+ N K+ADFGLA+ + Sbjct: 369 MAAQVAAGMAYIER---MNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGA 425 Query: 293 MGTFGYVAPEYAMTGHLLVKSDVYSYGVVLLELLS-GRKP 409 + APE A+ G +KSDV+S+G++L EL++ GR P Sbjct: 426 KFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVP 465
>ARAF_RAT (P14056) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) Length = 604 Score = 64.7 bits (156), Expect = 1e-10 Identities = 45/136 (33%), Positives = 70/136 (51%), Gaps = 5/136 (3%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 ++ + S+ HLH +D + D + +A A+G+ YLH ++IHRD K++ Sbjct: 378 IITQWCEGSSLYHHLHVADTRF---DMVQLIDVARQTAQGMDYLHAK---NIIHRDLKSN 431 Query: 197 NVLLENDFTAKVADFGLA--KEASEGIEHISTQVMGTFGYVAPEYAM---TGHLLVKSDV 361 N+ L T K+ DFGLA K G + + Q G+ ++A E +SDV Sbjct: 432 NIFLHEGLTVKIGDFGLATVKTRWSGAQPLE-QPSGSVLWMAAEVIRMQDPNPYSFQSDV 490 Query: 362 YSYGVVLLELLSGRKP 409 Y+YGVVL EL++G P Sbjct: 491 YAYGVVLYELMTGSLP 506
>ARAF_MOUSE (P04627) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) Length = 604 Score = 64.7 bits (156), Expect = 1e-10 Identities = 45/136 (33%), Positives = 70/136 (51%), Gaps = 5/136 (3%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 ++ + S+ HLH +D + D + +A A+G+ YLH ++IHRD K++ Sbjct: 378 IITQWCEGSSLYHHLHVADTRF---DMVQLIDVARQTAQGMDYLHAK---NIIHRDLKSN 431 Query: 197 NVLLENDFTAKVADFGLA--KEASEGIEHISTQVMGTFGYVAPEYAM---TGHLLVKSDV 361 N+ L T K+ DFGLA K G + + Q G+ ++A E +SDV Sbjct: 432 NIFLHEGLTVKIGDFGLATVKTRWSGAQPLE-QPSGSVLWMAAEVIRMQDPNPYSFQSDV 490 Query: 362 YSYGVVLLELLSGRKP 409 Y+YGVVL EL++G P Sbjct: 491 YAYGVVLYELMTGSLP 506
>FGR_MOUSE (P14234) Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2)| (P55-FGR) (C-FGR) Length = 517 Score = 64.7 bits (156), Expect = 1e-10 Identities = 37/100 (37%), Positives = 57/100 (57%), Gaps = 1/100 (1%) Frame = +2 Query: 113 IALGAARGLAYLHEDANPHVIHRDFKASNVLLENDFTAKVADFGLAKEASEGIEHISTQV 292 +A A G+AY+ + IHRD +A+N+L+ K+ADFGLA+ + + Sbjct: 350 MAAQVAEGMAYMER---MNYIHRDLRAANILVGEYLICKIADFGLARLIEDNEYNPQQGT 406 Query: 293 MGTFGYVAPEYAMTGHLLVKSDVYSYGVVLLELLS-GRKP 409 + APE A+ G VKSDV+S+G++L EL++ GR P Sbjct: 407 KFPIKWTAPEAALFGRFTVKSDVWSFGILLTELITKGRVP 446
>M3K6_HUMAN (O95382) Mitogen-activated protein kinase kinase kinase 6 (EC| 2.7.11.25) Length = 1011 Score = 64.7 bits (156), Expect = 1e-10 Identities = 48/138 (34%), Positives = 73/138 (52%), Gaps = 7/138 (5%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAAR---GLAYLHEDANPHVIHRDF 187 + E VP GS+ S L ++GPL D I+ + GL YLH++ H++HRD Sbjct: 443 IFMEEVPGGSLSSLLRS---VWGPLK-DNESTISFYTRQILQGLGYLHDN---HIVHRDI 495 Query: 188 KASNVLLENDFTA--KVADFGLAKEASEGIEHISTQVMGTFGYVAPEYAMTG--HLLVKS 355 K NVL+ N F+ K++DFG +K + GI + GT Y+APE G + Sbjct: 496 KGDNVLI-NTFSGLLKISDFGTSKRLA-GITPCTETFTGTLQYMAPEIIDQGPRGYGKAA 553 Query: 356 DVYSYGVVLLELLSGRKP 409 D++S G ++E+ +GR P Sbjct: 554 DIWSLGCTVIEMATGRPP 571
>ARAF_PIG (O19004) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (A-Raf-1) Length = 606 Score = 64.7 bits (156), Expect = 1e-10 Identities = 45/136 (33%), Positives = 70/136 (51%), Gaps = 5/136 (3%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 ++ + S+ HLH +D + D + +A A+G+ YLH ++IHRD K++ Sbjct: 380 IITQWCEGSSLYHHLHVADTRF---DMVQLIDVARQTAQGMDYLHAK---NIIHRDLKSN 433 Query: 197 NVLLENDFTAKVADFGLA--KEASEGIEHISTQVMGTFGYVAPEYAM---TGHLLVKSDV 361 N+ L T K+ DFGLA K G + + Q G+ ++A E +SDV Sbjct: 434 NIFLHEGLTVKIGDFGLATVKTRWSGAQPLE-QPSGSVLWMAAEVIRMQDPNPYSFQSDV 492 Query: 362 YSYGVVLLELLSGRKP 409 Y+YGVVL EL++G P Sbjct: 493 YAYGVVLYELMTGSLP 508
>ARAF_HUMAN (P10398) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (A-raf-1) (Proto-oncogene Pks) Length = 606 Score = 64.7 bits (156), Expect = 1e-10 Identities = 45/136 (33%), Positives = 70/136 (51%), Gaps = 5/136 (3%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 ++ + S+ HLH +D + D + +A A+G+ YLH ++IHRD K++ Sbjct: 380 IITQWCEGSSLYHHLHVADTRF---DMVQLIDVARQTAQGMDYLHAK---NIIHRDLKSN 433 Query: 197 NVLLENDFTAKVADFGLA--KEASEGIEHISTQVMGTFGYVAPEYAM---TGHLLVKSDV 361 N+ L T K+ DFGLA K G + + Q G+ ++A E +SDV Sbjct: 434 NIFLHEGLTVKIGDFGLATVKTRWSGAQPLE-QPSGSVLWMAAEVIRMQDPNPYSFQSDV 492 Query: 362 YSYGVVLLELLSGRKP 409 Y+YGVVL EL++G P Sbjct: 493 YAYGVVLYELMTGSLP 508
>RIPK3_MOUSE (Q9QZL0) Receptor-interacting serine/threonine-protein kinase 3 (EC| 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) (mRIP3) Length = 486 Score = 64.7 bits (156), Expect = 1e-10 Identities = 46/139 (33%), Positives = 71/139 (51%), Gaps = 7/139 (5%) Frame = +2 Query: 11 RCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFK 190 + LV + NGS+ L PL ++ LG + YLH +P ++HRD K Sbjct: 91 QALVTRFMENGSLAGLLQPECPRPWPLLCRLLQEVVLG----MCYLHS-LDPPLLHRDLK 145 Query: 191 ASNVLLENDFTAKVADFGLA-----KEASEGIEHISTQVMGTFGYVAPEYAMTGHLLVK- 352 SN+LL+ + AK+ADFGL+ ++ G S GT Y+ PE +L Sbjct: 146 PSNILLDPELHAKLADFGLSTFQGGSQSGSGSGSGSRDSGGTLAYLDPELLFKVNLKASK 205 Query: 353 -SDVYSYGVVLLELLSGRK 406 SDVYS+G+++ +L+GR+ Sbjct: 206 ASDVYSFGILVWAVLAGRE 224
>FGR_HUMAN (P09769) Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2)| (P55-FGR) (C-FGR) Length = 529 Score = 64.7 bits (156), Expect = 1e-10 Identities = 43/123 (34%), Positives = 66/123 (53%), Gaps = 7/123 (5%) Frame = +2 Query: 62 HGS--DKIYGPLDFDTRMK----IALGAARGLAYLHEDANPHVIHRDFKASNVLLENDFT 223 HGS D + P D R+ +A A G+AY+ + IHRD +A+N+L+ Sbjct: 339 HGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMER---MNYIHRDLRAANILVGERLA 395 Query: 224 AKVADFGLAKEASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYSYGVVLLELLS-G 400 K+ADFGLA+ + + + APE A+ G +KSDV+S+G++L EL++ G Sbjct: 396 CKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELITKG 455 Query: 401 RKP 409 R P Sbjct: 456 RIP 458
>M3K2_ARATH (Q9FZ36) Mitogen-activated protein kinase kinase kinase 2 (EC| 2.7.11.25) (Arabidospsis NPK1-related protein kinase 2) Length = 651 Score = 64.7 bits (156), Expect = 1e-10 Identities = 44/134 (32%), Positives = 72/134 (53%), Gaps = 3/134 (2%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 ++ E VP GS+ S L +G GL YLH A ++HRD K + Sbjct: 148 ILLEFVPGGSISSLLEK----FGAFPESVVRTYTNQLLLGLEYLHNHA---IMHRDIKGA 200 Query: 197 NVLLENDFTAKVADFGLAKEASEGIEHIS--TQVMGTFGYVAPEYAM-TGHLLVKSDVYS 367 N+L++N K+ADFG +K+ +E + IS + GT ++APE + TGH +D++S Sbjct: 201 NILVDNQGCIKLADFGASKQVAE-LATISGAKSMKGTPYWMAPEVILQTGHSF-SADIWS 258 Query: 368 YGVVLLELLSGRKP 409 G ++E+++G+ P Sbjct: 259 VGCTVIEMVTGKAP 272
>KPCD_CANFA (Q5PU49) Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta)| Length = 674 Score = 64.3 bits (155), Expect = 1e-10 Identities = 45/126 (35%), Positives = 62/126 (49%), Gaps = 5/126 (3%) Frame = +2 Query: 47 VESHLHGSDKIY-----GPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKASNVLLE 211 V L+G D +Y G + A GL +LH N +I+RD K NV+L+ Sbjct: 424 VMEFLNGGDLMYHIQDKGRFELYRATFYAAEIVCGLQFLH---NKGIIYRDLKLDNVMLD 480 Query: 212 NDFTAKVADFGLAKEASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYSYGVVLLEL 391 D K+ADFG+ KE G + ST GT Y+APE D +S+GV+L E+ Sbjct: 481 QDGHIKIADFGMCKENIFGEKQAST-FCGTPDYIAPEILQGLKYSFSVDWWSFGVLLYEM 539 Query: 392 LSGRKP 409 L G+ P Sbjct: 540 LIGQSP 545
>JAK1_MOUSE (P52332) Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1)| (JAK-1) Length = 1153 Score = 64.3 bits (155), Expect = 1e-10 Identities = 42/130 (32%), Positives = 69/130 (53%), Gaps = 3/130 (2%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 L+ E +P+GS++ +L K ++ ++K A+ +G+ YL + +HRD A Sbjct: 953 LIMEFLPSGSLKEYL---PKNKNKINLKQQLKYAIQICKGMDYL---GSRQYVHRDLAAR 1006 Query: 197 NVLLENDFTAKVADFGLAKEASEGIEHIST---QVMGTFGYVAPEYAMTGHLLVKSDVYS 367 NVL+E++ K+ DFGL K E+ + + F Y APE + + SDV+S Sbjct: 1007 NVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWY-APECLIQCKFYIASDVWS 1065 Query: 368 YGVVLLELLS 397 +GV L ELL+ Sbjct: 1066 FGVTLHELLT 1075
>FYN_XIPHE (P27446) Proto-oncogene tyrosine-protein kinase FYN (EC 2.7.10.2)| (P59-FYN) Length = 536 Score = 64.3 bits (155), Expect = 1e-10 Identities = 41/132 (31%), Positives = 69/132 (52%), Gaps = 1/132 (0%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 +V E + GS+ L + L + +A A G+AY+ + IHRD +++ Sbjct: 339 IVTEYMSKGSLLDFLKDGEG--RALKLPNLVDMAAQVAAGMAYIER---MNYIHRDLRSA 393 Query: 197 NVLLENDFTAKVADFGLAKEASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYSYGV 376 N+L+ ++ K+ADFGLA+ + + APE A+ G +KSDV+S+G+ Sbjct: 394 NILVGDNLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGI 453 Query: 377 VLLELLS-GRKP 409 +L EL++ GR P Sbjct: 454 LLTELVTKGRVP 465
>TESK2_HUMAN (Q96S53) Dual specificity testis-specific protein kinase 2 (EC| 2.7.12.1) (Testicular protein kinase 2) Length = 571 Score = 64.3 bits (155), Expect = 1e-10 Identities = 47/134 (35%), Positives = 76/134 (56%), Gaps = 10/134 (7%) Frame = +2 Query: 26 ELVPNGSVE----SHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKA 193 E + +G++E S+LH L + R+K+A A GL+YLH + HRD + Sbjct: 131 EYINSGNLEQLLDSNLH--------LPWTVRVKLAYDIAVGLSYLHFKG---IFHRDLTS 179 Query: 194 SNVLL---ENDFTAKVADFGLAK---EASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKS 355 N L+ EN ++A VADFGLA+ + S G E ++ V+G+ ++APE K+ Sbjct: 180 KNCLIKRDENGYSAVVADFGLAEKIPDVSMGSEKLA--VVGSPFWMAPEVLRDEPYNEKA 237 Query: 356 DVYSYGVVLLELLS 397 DV+SYG++L E+++ Sbjct: 238 DVFSYGIILCEIIA 251
>KPC1_APLCA (Q16974) Calcium-dependent protein kinase C (EC 2.7.11.13) (APL I)| Length = 649 Score = 63.9 bits (154), Expect = 2e-10 Identities = 43/132 (32%), Positives = 66/132 (50%) Frame = +2 Query: 20 VFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKASN 199 V E V G + + K P+ +IA+G L YLH +++RD K N Sbjct: 397 VMEYVNGGDLMYRIQQEGKFKEPVAAFYAAEIAIG----LFYLHTQG---IVYRDLKLDN 449 Query: 200 VLLENDFTAKVADFGLAKEASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYSYGVV 379 V+L+ + K+ADFG+ KE G + + GT Y+APE + D ++YGV+ Sbjct: 450 VMLDAEGHIKIADFGMCKENIMG-DKTTRTFCGTPDYIAPEIVLYQPYGRSVDWWAYGVL 508 Query: 380 LLELLSGRKPVD 415 L E+L+G+ P D Sbjct: 509 LYEMLAGQPPFD 520
>MOS_XENLA (P12965) Serine/threonine-protein kinase mos (EC 2.7.11.1)| (pp39-mos) Length = 359 Score = 63.9 bits (154), Expect = 2e-10 Identities = 41/139 (29%), Positives = 66/139 (47%), Gaps = 8/139 (5%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 ++ E G++ ++G PL + M+ A A GL +LH D V+H D K + Sbjct: 140 IIMEYTGTGTLHQRIYGRSP---PLGAEICMRYARHVADGLRFLHRDG---VVHLDLKPA 193 Query: 197 NVLLENDFTAKVADFGLAKEASEGIEHISTQ--------VMGTFGYVAPEYAMTGHLLVK 352 NVLL K+ DFG ++ EG E + V GT+ + APE + K Sbjct: 194 NVLLAPGDLCKIGDFGCSQRLREGDEAAGGEPCCTQLRHVGGTYTHRAPELLKGEPVTAK 253 Query: 353 SDVYSYGVVLLELLSGRKP 409 +D+YS+ + L +++S P Sbjct: 254 ADIYSFAITLWQMVSRELP 272
>KPC2_CAEEL (P90980) Protein kinase C-like 2 (EC 2.7.11.13) (PKC2)| Length = 682 Score = 63.9 bits (154), Expect = 2e-10 Identities = 44/132 (33%), Positives = 65/132 (49%) Frame = +2 Query: 20 VFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKASN 199 V E V G + + K P+ +IA+G L +LH +I+RD K N Sbjct: 425 VMEFVNGGDLMYQIQQVGKFKEPVAVFYAAEIAVG----LFFLHSKG---IIYRDLKLDN 477 Query: 200 VLLENDFTAKVADFGLAKEASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYSYGVV 379 V+LE D K+ DFG+ KE G + + GT Y+APE + D ++YGV+ Sbjct: 478 VMLERDGHIKITDFGMCKENIFG-DATTKTFCGTPDYIAPEIILYQPYGKSVDWWAYGVL 536 Query: 380 LLELLSGRKPVD 415 L E+L+G+ P D Sbjct: 537 LFEMLAGQPPFD 548
>YSK4_HUMAN (Q56UN5) SPS1/STE20-related protein kinase YSK4 (EC 2.7.11.1)| (Regulated in COPD, protein kinase) Length = 1328 Score = 63.9 bits (154), Expect = 2e-10 Identities = 45/140 (32%), Positives = 71/140 (50%), Gaps = 5/140 (3%) Frame = +2 Query: 8 TRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDF 187 T + E VP GS+ S ++ +GPL K +G+AYLHE+ V+HRD Sbjct: 1135 TVSIFMEFVPGGSISSIINR----FGPLPEMVFCKYTKQILQGVAYLHENC---VVHRDI 1187 Query: 188 KASNVLLENDFTAKVADFGLAKE-ASEGIEHISTQVM----GTFGYVAPEYAMTGHLLVK 352 K +NV+L K+ DFG A+ A G+ + ++ GT ++APE K Sbjct: 1188 KGNNVMLMPTGIIKLIDFGCARRLAWAGLNGTHSDMLKSMHGTPYWMAPEVINESGYGRK 1247 Query: 353 SDVYSYGVVLLELLSGRKPV 412 SD++S G + E+ +G+ P+ Sbjct: 1248 SDIWSIGCTVFEMATGKPPL 1267
>STK_HYDAT (P17713) Tyrosine-protein kinase STK (EC 2.7.10.2) (P57-STK)| Length = 509 Score = 63.9 bits (154), Expect = 2e-10 Identities = 44/134 (32%), Positives = 71/134 (52%), Gaps = 3/134 (2%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 +V E + GS+ +L + + L T + +A A G+A+L IHRD A Sbjct: 310 IVTEYMSGGSLLDYLSKGEGVN--LQLPTLIDMAAQVASGMAFLEAQG---YIHRDLAAR 364 Query: 197 NVLLENDFTAKVADFGLAK--EASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYSY 370 N+L+ ++ KVADFGLA+ E E H + + APE A+ +KSDV+S+ Sbjct: 365 NILVGENYICKVADFGLARLIEDDEYTAHEGAKF--PIKWTAPEAALYNRFTIKSDVWSF 422 Query: 371 GVVLLELLS-GRKP 409 G+++ E+++ GR P Sbjct: 423 GILMAEIVTKGRIP 436
>RIPK1_MOUSE (Q60855) Receptor-interacting serine/threonine-protein kinase 1 (EC| 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein) Length = 656 Score = 63.5 bits (153), Expect = 2e-10 Identities = 48/148 (32%), Positives = 74/148 (50%), Gaps = 15/148 (10%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 LV E + G++ L +I PL R I + A G+ YLH+ VIH+D K Sbjct: 90 LVMEYMEKGNLMHVL--KTQIDVPLSLKGR--IIVEAIEGMCYLHDKG---VIHKDLKPE 142 Query: 197 NVLLENDFTAKVADFGLA---------KEASEGIEHISTQVM----GTFGYVAPEYA--M 331 N+L++ DF K+AD G+A KE + +S+ GT Y+APE+ + Sbjct: 143 NILVDRDFHIKIADLGVASFKTWSKLTKEKDNKQKEVSSTTKKNNGGTLYYMAPEHLNDI 202 Query: 332 TGHLLVKSDVYSYGVVLLELLSGRKPVD 415 KSDVYS+G+VL + + ++P + Sbjct: 203 NAKPTEKSDVYSFGIVLWAIFAKKEPYE 230
>MK01_HUMAN (P28482) Mitogen-activated protein kinase 1 (EC 2.7.11.24)| (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1) Length = 359 Score = 63.5 bits (153), Expect = 2e-10 Identities = 38/94 (40%), Positives = 53/94 (56%), Gaps = 3/94 (3%) Frame = +2 Query: 131 RGLAYLHEDANPHVIHRDFKASNVLLENDFTAKVADFGLAKEASEGIEHIS--TQVMGTF 304 RGL Y+H + +V+HRD K SN+LL K+ DFGLA+ A +H T+ + T Sbjct: 134 RGLKYIH---SANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATR 190 Query: 305 GYVAPEYAMTGHLLVKS-DVYSYGVVLLELLSGR 403 Y APE + KS D++S G +L E+LS R Sbjct: 191 WYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNR 224
>MK01_BOVIN (P46196) Mitogen-activated protein kinase 1 (EC 2.7.11.24)| (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1) Length = 359 Score = 63.5 bits (153), Expect = 2e-10 Identities = 38/94 (40%), Positives = 53/94 (56%), Gaps = 3/94 (3%) Frame = +2 Query: 131 RGLAYLHEDANPHVIHRDFKASNVLLENDFTAKVADFGLAKEASEGIEHIS--TQVMGTF 304 RGL Y+H + +V+HRD K SN+LL K+ DFGLA+ A +H T+ + T Sbjct: 134 RGLKYIH---SANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATR 190 Query: 305 GYVAPEYAMTGHLLVKS-DVYSYGVVLLELLSGR 403 Y APE + KS D++S G +L E+LS R Sbjct: 191 WYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNR 224
>JAK2_RAT (Q62689) Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2)| (JAK-2) Length = 1132 Score = 63.5 bits (153), Expect = 2e-10 Identities = 47/153 (30%), Positives = 70/153 (45%), Gaps = 7/153 (4%) Frame = +2 Query: 2 RRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHR 181 RR L+ E +P GS+ +L K +D ++ +G+ YL IHR Sbjct: 922 RRNLRLIMEYLPYGSLRDYLQ---KHKERIDHKKLLQYTSQICKGMEYL---GTKRYIHR 975 Query: 182 DFKASNVLLENDFTAKVADFGLAKEASEGIEHISTQVMG--TFGYVAPEYAMTGHLLVKS 355 D N+L+EN+ K+ DFGL K + E+ + G + APE V S Sbjct: 976 DLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVAS 1035 Query: 356 DVYSYGVVLLELL-----SGRKPVDMTQPSGSE 439 DV+S+GVVL EL S PV+ + G++ Sbjct: 1036 DVWSFGVVLYELFTYIEKSKSPPVEFMRMIGND 1068
>MK01_XENLA (P26696) Mitogen-activated protein kinase 1 (EC 2.7.11.24) (Myelin| xP42 protein kinase) (Myelin basic protein kinase) (MBP kinase) (M phase MAP kinase) Length = 361 Score = 63.5 bits (153), Expect = 2e-10 Identities = 38/94 (40%), Positives = 53/94 (56%), Gaps = 3/94 (3%) Frame = +2 Query: 131 RGLAYLHEDANPHVIHRDFKASNVLLENDFTAKVADFGLAKEASEGIEHIS--TQVMGTF 304 RGL Y+H + +V+HRD K SN+LL K+ DFGLA+ A +H T+ + T Sbjct: 138 RGLKYIH---SANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATR 194 Query: 305 GYVAPEYAMTGHLLVKS-DVYSYGVVLLELLSGR 403 Y APE + KS D++S G +L E+LS R Sbjct: 195 WYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNR 228
>MK01_RAT (P63086) Mitogen-activated protein kinase 1 (EC 2.7.11.24)| (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1) Length = 357 Score = 63.5 bits (153), Expect = 2e-10 Identities = 38/94 (40%), Positives = 53/94 (56%), Gaps = 3/94 (3%) Frame = +2 Query: 131 RGLAYLHEDANPHVIHRDFKASNVLLENDFTAKVADFGLAKEASEGIEHIS--TQVMGTF 304 RGL Y+H + +V+HRD K SN+LL K+ DFGLA+ A +H T+ + T Sbjct: 132 RGLKYIH---SANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATR 188 Query: 305 GYVAPEYAMTGHLLVKS-DVYSYGVVLLELLSGR 403 Y APE + KS D++S G +L E+LS R Sbjct: 189 WYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNR 222
>MK01_MOUSE (P63085) Mitogen-activated protein kinase 1 (EC 2.7.11.24)| (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1) Length = 357 Score = 63.5 bits (153), Expect = 2e-10 Identities = 38/94 (40%), Positives = 53/94 (56%), Gaps = 3/94 (3%) Frame = +2 Query: 131 RGLAYLHEDANPHVIHRDFKASNVLLENDFTAKVADFGLAKEASEGIEHIS--TQVMGTF 304 RGL Y+H + +V+HRD K SN+LL K+ DFGLA+ A +H T+ + T Sbjct: 132 RGLKYIH---SANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATR 188 Query: 305 GYVAPEYAMTGHLLVKS-DVYSYGVVLLELLSGR 403 Y APE + KS D++S G +L E+LS R Sbjct: 189 WYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNR 222
>ANKK1_MOUSE (Q8BZ25) Ankyrin repeat and protein kinase domain-containing| protein 1 (EC 2.7.11.1) Length = 745 Score = 63.5 bits (153), Expect = 2e-10 Identities = 42/136 (30%), Positives = 75/136 (55%), Gaps = 5/136 (3%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 +V E + +GS+E L + + PL +++I + + +LH P ++H D K Sbjct: 108 IVMEFMASGSLEKTLP-THSLCWPL----KLRIIHETSLAMNFLHS-IKPPLLHLDLKPG 161 Query: 197 NVLLENDFTAKVADFGLAK--EASEGIEHISTQVM-GTFGYVAPEYAMTGHLL--VKSDV 361 N+LL+N+ K++DFGL+K E S ++I + GT Y+ PE + + + DV Sbjct: 162 NILLDNNMHVKISDFGLSKWMEQSTQKQYIERSALRGTLSYIPPEMFLENNKAPGPEYDV 221 Query: 362 YSYGVVLLELLSGRKP 409 YS+ +V+ E+L+ +KP Sbjct: 222 YSFAIVIWEILTQKKP 237
>KOK0_YEAST (Q12236) Probable serine/threonine-protein kinase YOL100W (EC| 2.7.11.1) Length = 1081 Score = 63.5 bits (153), Expect = 2e-10 Identities = 43/144 (29%), Positives = 68/144 (47%), Gaps = 10/144 (6%) Frame = +2 Query: 20 VFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKASN 199 + E PNG S + K YG LD A + YLH + +IHRD K N Sbjct: 256 LLEYAPNGDFLSLM----KKYGSLDETCARYYAAQIIDAIDYLHSNG---IIHRDIKPEN 308 Query: 200 VLLENDFTAKVADFGLAK-------EASEGIEHISTQ---VMGTFGYVAPEYAMTGHLLV 349 +LL+ + K+ DFG AK S+ +ST+ +GT YV+PE Sbjct: 309 ILLDGEMKIKLTDFGTAKLLNPTNNSVSKPEYDLSTRSKSFVGTAEYVSPELLNDSFTDY 368 Query: 350 KSDVYSYGVVLLELLSGRKPVDMT 421 + D++++G +L ++++G+ P T Sbjct: 369 RCDIWAFGCILFQMIAGKPPFKAT 392
>M3K3_ARATH (O22042) Mitogen-activated protein kinase kinase kinase 3 (EC| 2.7.11.25) (Arabidospsis NPK1-related protein kinase 3) Length = 651 Score = 63.5 bits (153), Expect = 2e-10 Identities = 42/133 (31%), Positives = 72/133 (54%), Gaps = 2/133 (1%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 ++ E VP GS+ S L P+ ++ LG L YLH N ++HRD K + Sbjct: 148 ILMEFVPGGSISSLLEKFGSFPEPVIIMYTKQLLLG----LEYLH---NNGIMHRDIKGA 200 Query: 197 NVLLENDFTAKVADFGLAKEASE-GIEHISTQVMGTFGYVAPEYAM-TGHLLVKSDVYSY 370 N+L++N ++ADFG +K+ E + + + GT ++APE + TGH +D++S Sbjct: 201 NILVDNKGCIRLADFGASKKVVELATVNGAKSMKGTPYWMAPEVILQTGHSF-SADIWSV 259 Query: 371 GVVLLELLSGRKP 409 G ++E+ +G+ P Sbjct: 260 GCTVIEMATGKPP 272
>CHK1_DROME (O61661) Serine/threonine-protein kinase grp (EC 2.7.11.1) (Protein| grapes) (Chk1 homolog) Length = 512 Score = 63.5 bits (153), Expect = 2e-10 Identities = 38/100 (38%), Positives = 56/100 (56%), Gaps = 1/100 (1%) Frame = +2 Query: 134 GLAYLHEDANPHVIHRDFKASNVLLENDFTAKVADFGLAKE-ASEGIEHISTQVMGTFGY 310 GL YLH+ + HRD K N+LL+ K++DFG+A +G E + + GT Y Sbjct: 130 GLNYLHQRG---IAHRDLKPENLLLDEHDNVKISDFGMATMFRCKGKERLLDKRCGTLPY 186 Query: 311 VAPEYAMTGHLLVKSDVYSYGVVLLELLSGRKPVDMTQPS 430 VAPE + +D++S GV+L+ +L+G P D QPS Sbjct: 187 VAPEVLQKAYHAQPADLWSCGVILVTMLAGELPWD--QPS 224
>KPCD_HUMAN (Q05655) Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta)| Length = 676 Score = 63.2 bits (152), Expect = 3e-10 Identities = 38/92 (41%), Positives = 50/92 (54%) Frame = +2 Query: 134 GLAYLHEDANPHVIHRDFKASNVLLENDFTAKVADFGLAKEASEGIEHISTQVMGTFGYV 313 GL +LH +I+RD K NVLL+ D K+ADFG+ KE G ST GT Y+ Sbjct: 460 GLQFLHSKG---IIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRAST-FCGTPDYI 515 Query: 314 APEYAMTGHLLVKSDVYSYGVVLLELLSGRKP 409 APE D +S+GV+L E+L G+ P Sbjct: 516 APEILQGLKYTFSVDWWSFGVLLYEMLIGQSP 547
>SKM1_YEAST (Q12469) Serine/threonine-protein kinase SKM1 (EC 2.7.11.1)| (Protein kinase 75490 D) Length = 655 Score = 63.2 bits (152), Expect = 3e-10 Identities = 38/108 (35%), Positives = 57/108 (52%) Frame = +2 Query: 86 PLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKASNVLLENDFTAKVADFGLAKEASE 265 PL+ + I +GL +LH N +IHRD K+ N+LL + K+ DFG E +E Sbjct: 478 PLNENQMAYIVKETCQGLKFLH---NKKIIHRDIKSDNILLNSQGLVKITDFGFCVELTE 534 Query: 266 GIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYSYGVVLLELLSGRKP 409 +T V GT ++APE K DV+S G++L+E++ G P Sbjct: 535 KRSKRATMV-GTPYWMAPEIVNQKGYDEKVDVWSLGIMLIEMIEGEPP 581
>EPHA7_RAT (P54759) Ephrin type-A receptor 7 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) Length = 998 Score = 63.2 bits (152), Expect = 3e-10 Identities = 41/134 (30%), Positives = 70/134 (52%), Gaps = 3/134 (2%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 +V E + NG++++ L D + + ++ G A G+ YL A+ +HRD A Sbjct: 709 IVIEFMENGALDAFLRKHDGQFTVIQLVGMLR---GIAAGMRYL---ADMGYVHRDLAAR 762 Query: 197 NVLLENDFTAKVADFGLAKEASEGIEHISTQVMGTF--GYVAPEYAMTGHLLVKSDVYSY 370 N+L+ ++ KV+DFGL++ + E + T G + APE SDV+SY Sbjct: 763 NILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPEAIQYRKFTSASDVWSY 822 Query: 371 GVVLLELLS-GRKP 409 G+V+ E++S G +P Sbjct: 823 GIVMWEVMSYGERP 836
>EPHA7_MOUSE (Q61772) Ephrin type-A receptor 7 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Embryonic brain kinase) (EBK) (Developmental kinase 1) (MDK-1) Length = 998 Score = 63.2 bits (152), Expect = 3e-10 Identities = 41/134 (30%), Positives = 70/134 (52%), Gaps = 3/134 (2%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 +V E + NG++++ L D + + ++ G A G+ YL A+ +HRD A Sbjct: 709 IVIEFMENGALDAFLRKHDGQFTVIQLVGMLR---GIAAGMRYL---ADMGYVHRDLAAR 762 Query: 197 NVLLENDFTAKVADFGLAKEASEGIEHISTQVMGTF--GYVAPEYAMTGHLLVKSDVYSY 370 N+L+ ++ KV+DFGL++ + E + T G + APE SDV+SY Sbjct: 763 NILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPEAIQYRKFTSASDVWSY 822 Query: 371 GVVLLELLS-GRKP 409 G+V+ E++S G +P Sbjct: 823 GIVMWEVMSYGERP 836
>EPHA7_HUMAN (Q15375) Ephrin type-A receptor 7 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Receptor protein-tyrosine kinase HEK11) Length = 998 Score = 63.2 bits (152), Expect = 3e-10 Identities = 41/134 (30%), Positives = 70/134 (52%), Gaps = 3/134 (2%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 +V E + NG++++ L D + + ++ G A G+ YL A+ +HRD A Sbjct: 709 IVIEFMENGALDAFLRKHDGQFTVIQLVGMLR---GIAAGMRYL---ADMGYVHRDLAAR 762 Query: 197 NVLLENDFTAKVADFGLAKEASEGIEHISTQVMGTF--GYVAPEYAMTGHLLVKSDVYSY 370 N+L+ ++ KV+DFGL++ + E + T G + APE SDV+SY Sbjct: 763 NILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPEAIQYRKFTSASDVWSY 822 Query: 371 GVVLLELLS-GRKP 409 G+V+ E++S G +P Sbjct: 823 GIVMWEVMSYGERP 836
>RK_BOVIN (P28327) Rhodopsin kinase precursor (EC 2.7.11.14) (RK) (G| protein-coupled receptor kinase 1) Length = 561 Score = 63.2 bits (152), Expect = 3e-10 Identities = 38/132 (28%), Positives = 65/132 (49%) Frame = +2 Query: 14 CLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKA 193 CLV ++ G + H++ D+ + GL +LH+ ++I+RD K Sbjct: 261 CLVMTIMNGGDIRYHIYNVDEDNPGFQEPRAIFYTAQIVSGLEHLHQR---NIIYRDLKP 317 Query: 194 SNVLLENDFTAKVADFGLAKEASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYSYG 373 NVLL++D +++D GLA E G + + GT G++APE + D ++ G Sbjct: 318 ENVLLDDDGNVRISDLGLAVELKAG-QTKTKGYAGTPGFMAPELLLGEEYDFSVDYFALG 376 Query: 374 VVLLELLSGRKP 409 V L E+++ R P Sbjct: 377 VTLYEMIAARGP 388
>ROR1_DROME (Q24488) Tyrosine-protein kinase transmembrane receptor Ror| precursor (EC 2.7.10.1) (dRor) Length = 685 Score = 63.2 bits (152), Expect = 3e-10 Identities = 42/138 (30%), Positives = 71/138 (51%), Gaps = 6/138 (4%) Frame = +2 Query: 14 CLVFELVPNGSVESHLHGSDKIYGP----LDFDTRMKIALGAARGLAYLHEDANPHVIHR 181 C++FE + NG + L + G L+F ++IAL + G+ YL H +HR Sbjct: 485 CMLFEYMANGDLHEFLISNSPTEGKSLSQLEF---LQIALQISEGMQYLSAH---HYVHR 538 Query: 182 DFKASNVLLENDFTAKVADFGLAKEA-SEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSD 358 D A N L+ K++DFGL+++ S + ++ + ++ E + G +SD Sbjct: 539 DLAARNCLVNEGLVVKISDFGLSRDIYSSDYYRVQSKSLLPVRWMPSESILYGKFTTESD 598 Query: 359 VYSYGVVLLELLS-GRKP 409 V+S+GVVL E+ S G +P Sbjct: 599 VWSFGVVLWEIYSYGMQP 616
>ITK_HUMAN (Q08881) Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2)| (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT) Length = 620 Score = 63.2 bits (152), Expect = 3e-10 Identities = 41/131 (31%), Positives = 64/131 (48%) Frame = +2 Query: 14 CLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKA 193 CLVFE + +G + +L ++ +T + + L G+AYL E VIHRD A Sbjct: 432 CLVFEFMEHGCLSDYLRTQRGLFAA---ETLLGMCLDVCEGMAYLEEAC---VIHRDLAA 485 Query: 194 SNVLLENDFTAKVADFGLAKEASEGIEHISTQVMGTFGYVAPEYAMTGHLLVKSDVYSYG 373 N L+ + KV+DFG+ + + ST + +PE KSDV+S+G Sbjct: 486 RNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFG 545 Query: 374 VVLLELLSGRK 406 V++ E+ S K Sbjct: 546 VLMWEVFSEGK 556
>EPHA7_CHICK (O42422) Ephrin type-A receptor 7 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor CEPHA7) (Tyrosine-protein kinase receptor CEK11) Length = 993 Score = 62.8 bits (151), Expect = 4e-10 Identities = 41/134 (30%), Positives = 70/134 (52%), Gaps = 3/134 (2%) Frame = +2 Query: 17 LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFKAS 196 +V E + NG++++ L D + + ++ G A G+ YL A+ +HRD A Sbjct: 704 IVIEYMENGALDAFLRKHDGQFTVIQLVGMLR---GIAAGMRYL---ADMGYVHRDLAAR 757 Query: 197 NVLLENDFTAKVADFGLAKEASEGIEHISTQVMGTF--GYVAPEYAMTGHLLVKSDVYSY 370 N+L+ ++ KV+DFGL++ + E + T G + APE SDV+SY Sbjct: 758 NILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPEAIQYRKFTSASDVWSY 817 Query: 371 GVVLLELLS-GRKP 409 G+V+ E++S G +P Sbjct: 818 GIVMWEVMSYGERP 831
>CHK1_YEAST (P38147) Serine/threonine-protein kinase CHK1 (EC 2.7.11.1)| (Checkpoint kinase 1) Length = 527 Score = 62.8 bits (151), Expect = 4e-10 Identities = 35/96 (36%), Positives = 57/96 (59%), Gaps = 4/96 (4%) Frame = +2 Query: 143 YLHEDANPHVIHRDFKASNVLLENDFTAKVADFGLAKE--ASEGIEHISTQVMGTFGYVA 316 YLH + V HRD K N+LL+ + K+ADFGLA + +G +S G+ Y+A Sbjct: 131 YLHVECG--VAHRDIKPENILLDKNGNLKLADFGLASQFRRKDGTLRVSMDQRGSPPYMA 188 Query: 317 PE--YAMTGHLLVKSDVYSYGVVLLELLSGRKPVDM 418 PE Y+ G+ ++D++S G++L LL+G+ P ++ Sbjct: 189 PEVLYSEEGYYADRTDIWSIGILLFVLLTGQTPWEL 224
>ERKA_DROME (P40417) Mitogen-activated protein kinase ERK-A (EC 2.7.11.24)| (Extracellular-regulated kinase A) (Protein rolled) Length = 376 Score = 62.8 bits (151), Expect = 4e-10 Identities = 38/94 (40%), Positives = 53/94 (56%), Gaps = 3/94 (3%) Frame = +2 Query: 131 RGLAYLHEDANPHVIHRDFKASNVLLENDFTAKVADFGLAKEASEGIEHIS--TQVMGTF 304 RGL Y+H + +V+HRD K SN+LL K+ DFGLA+ A +H T+ + T Sbjct: 148 RGLKYIH---SANVLHRDLKPSNLLLNKTCDLKICDFGLARIADPEHDHTGFLTEYVATR 204 Query: 305 GYVAPEYAMTGHLLVKS-DVYSYGVVLLELLSGR 403 Y APE + KS D++S G +L E+LS R Sbjct: 205 WYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNR 238
>SUR1_CAEEL (P39745) Mitogen-activated protein kinase mpk-1 (EC 2.7.11.24) (MAP| kinase sur-1) Length = 444 Score = 62.8 bits (151), Expect = 4e-10 Identities = 38/94 (40%), Positives = 52/94 (55%), Gaps = 3/94 (3%) Frame = +2 Query: 131 RGLAYLHEDANPHVIHRDFKASNVLLENDFTAKVADFGLAKEASEGIEHIS--TQVMGTF 304 RGL Y+H + +V+HRD K SN+LL K+ DFGLA+ +H T+ + T Sbjct: 206 RGLKYIH---SANVLHRDLKPSNLLLNTTCDLKICDFGLARVTDPQTDHTGFLTEYVATR 262 Query: 305 GYVAPEYAMTGHLLVKS-DVYSYGVVLLELLSGR 403 Y APE + KS DV+S G +L E+LS R Sbjct: 263 WYRAPEIMLNSKGYTKSIDVWSVGCILAEMLSNR 296 Database: uniprot_sprot.fasta Posted date: May 25, 2006 5:36 PM Number of letters in database: 80,573,946 Number of sequences in database: 219,361 Lambda K H 0.318 0.135 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 77,179,848 Number of Sequences: 219361 Number of extensions: 1829960 Number of successful extensions: 9410 Number of sequences better than 10.0: 500 Number of HSP's better than 10.0 without gapping: 7479 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 8297 length of database: 80,573,946 effective HSP length: 102 effective length of database: 58,199,124 effective search space used: 2677159704 frameshift window, decay const: 50, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)
