ナショナルバイオリソースプロジェクト
-Barley Genetic Resources Database-
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| Clone Name | bast63c05 |
|---|---|
| Clone Library Name | barley_pub |
>CTR1_ARATH (Q05609) Serine/threonine-protein kinase CTR1 (EC 2.7.11.1)| Length = 821 Score = 74.3 bits (181), Expect = 2e-13 Identities = 41/108 (37%), Positives = 62/108 (57%) Frame = +3 Query: 147 DLEELRELGSGTFGTVYHGKWRGTDVAIKRIKKSCFTGRSSEQERLAQEFWREAEILSKL 326 DL ++G+G+FGTV+ +W G+DVA+K + + F ER+ EF RE I+ +L Sbjct: 550 DLNIKEKIGAGSFGTVHRAEWHGSDVAVKILMEQDF-----HAERV-NEFLREVAIMKRL 603 Query: 327 HHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQRKGQCPDLPQR 470 HPN+V F G V P L+ +TE++ GSL +L + G L +R Sbjct: 604 RHPNIVLFMGAVTQPP--NLSIVTEYLSRGSLYRLLHKSGAREQLDER 649
>BMX_HUMAN (P51813) Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2)| (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38) Length = 675 Score = 72.8 bits (177), Expect = 5e-13 Identities = 46/107 (42%), Positives = 66/107 (61%), Gaps = 2/107 (1%) Frame = +3 Query: 135 IKNEDLEELRELGSGTFGTVYHGKWRGT-DVAIKRIKKSCFTGRSSEQERLAQEFWREAE 311 +K E++ L+ELGSG FG V GKW+G DVA+K IK+ G SE EF++EA+ Sbjct: 412 LKREEITLLKELGSGQFGVVQLGKWKGQYDVAVKMIKE----GSMSE-----DEFFQEAQ 462 Query: 312 ILSKLHHPNVVAFYGVV-KDGPGGTLATLTEFMVNGSLRHVLQRKGQ 449 + KL HP +V FYGV K+ P + +TE++ NG L + L+ G+ Sbjct: 463 TMMKLSHPKLVKFYGVCSKEYP---IYIVTEYISNGCLLNYLRSHGK 506
>BMX_MOUSE (P97504) Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2)| (Bone marrow tyrosine kinase gene in chromosome X protein homolog) Length = 651 Score = 69.7 bits (169), Expect = 4e-12 Identities = 44/107 (41%), Positives = 65/107 (60%), Gaps = 2/107 (1%) Frame = +3 Query: 135 IKNEDLEELRELGSGTFGTVYHGKWRGT-DVAIKRIKKSCFTGRSSEQERLAQEFWREAE 311 +K E++ L+ELG+G FG V G+W+G DVA+K IK+ G SE EF++EA+ Sbjct: 388 LKREEITLLKELGNGQFGVVQLGQWKGQYDVAVKMIKE----GAMSE-----DEFFQEAQ 438 Query: 312 ILSKLHHPNVVAFYGVV-KDGPGGTLATLTEFMVNGSLRHVLQRKGQ 449 + KL HP +V FYGV K P + +TE++ NG L + L+ G+ Sbjct: 439 TMMKLSHPKLVKFYGVCSKKYP---IYIVTEYITNGCLLNYLKSHGK 482
>TNI3K_RAT (Q7TQP6) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 834 Score = 69.3 bits (168), Expect = 5e-12 Identities = 45/120 (37%), Positives = 65/120 (54%) Frame = +3 Query: 123 HLQIIKNEDLEELRELGSGTFGTVYHGKWRGTDVAIKRIKKSCFTGRSSEQERLAQEFWR 302 HLQ+ ++E +GSG+FG VY G+ R VAIKR + + + +S F R Sbjct: 456 HLQL---SEIEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCSKSD-----VDMFCR 507 Query: 303 EAEILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQRKGQCPDLPQRLIIA 482 E IL +L+HP VV F G D P A +T+++ GSL +L + + DL +LIIA Sbjct: 508 EVSILCQLNHPCVVQFVGACLDDP-SQFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIA 566
>TNI3K_MOUSE (Q5GIG6) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 833 Score = 69.3 bits (168), Expect = 5e-12 Identities = 45/120 (37%), Positives = 65/120 (54%) Frame = +3 Query: 123 HLQIIKNEDLEELRELGSGTFGTVYHGKWRGTDVAIKRIKKSCFTGRSSEQERLAQEFWR 302 HLQ+ ++E +GSG+FG VY G+ R VAIKR + + + +S F R Sbjct: 455 HLQL---SEIEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCSKSD-----VDMFCR 506 Query: 303 EAEILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQRKGQCPDLPQRLIIA 482 E IL +L+HP VV F G D P A +T+++ GSL +L + + DL +LIIA Sbjct: 507 EVSILCQLNHPCVVQFVGACLDDP-SQFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIA 565
>BTKL_DROME (P08630) Tyrosine-protein kinase Btk29A (EC 2.7.10.2) (Dsrc28C)| Length = 786 Score = 67.0 bits (162), Expect = 2e-11 Identities = 43/100 (43%), Positives = 61/100 (61%), Gaps = 2/100 (2%) Frame = +3 Query: 147 DLEELRELGSGTFGTVYHGKWRGT-DVAIKRIKKSCFTGRSSEQERLAQEFWREAEILSK 323 +L + ELGSG FG V GKWRG+ D A+K +K+ G SE +F EA++++K Sbjct: 525 ELMLMEELGSGQFGVVRRGKWRGSIDTAVKMMKE----GTMSE-----DDFIEEAKVMTK 575 Query: 324 LHHPNVVAFYGVV-KDGPGGTLATLTEFMVNGSLRHVLQR 440 L HPN+V YGV K P + +TE+M +GSL + L+R Sbjct: 576 LQHPNLVQLYGVCSKHRP---IYIVTEYMKHGSLLNYLRR 612
>TNI3K_HUMAN (Q59H18) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 936 Score = 67.0 bits (162), Expect = 2e-11 Identities = 43/120 (35%), Positives = 65/120 (54%) Frame = +3 Query: 123 HLQIIKNEDLEELRELGSGTFGTVYHGKWRGTDVAIKRIKKSCFTGRSSEQERLAQEFWR 302 HLQ+ ++E +GSG+FG VY G+ R VAIKR + + + +S F R Sbjct: 558 HLQL---SEIEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCSKSD-----VDMFCR 609 Query: 303 EAEILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQRKGQCPDLPQRLIIA 482 E IL +L+HP V+ F G + P A +T+++ GSL +L + + DL +LIIA Sbjct: 610 EVSILCQLNHPCVIQFVGACLNDP-SQFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIA 668
>TNI3K_PONPY (Q5RF15) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) Length = 617 Score = 67.0 bits (162), Expect = 2e-11 Identities = 43/120 (35%), Positives = 65/120 (54%) Frame = +3 Query: 123 HLQIIKNEDLEELRELGSGTFGTVYHGKWRGTDVAIKRIKKSCFTGRSSEQERLAQEFWR 302 HLQ+ ++E +GSG+FG VY G+ R VAIKR + + + +S F R Sbjct: 456 HLQL---SEIEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCSKSD-----VDMFCR 507 Query: 303 EAEILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQRKGQCPDLPQRLIIA 482 E IL +L+HP V+ F G + P A +T+++ GSL +L + + DL +LIIA Sbjct: 508 EVSILCQLNHPCVIQFVGACLNDP-SQFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIA 566
>KYK1_DICDI (P18160) Non-receptor tyrosine kinase spore lysis A (EC 2.7.10.2)| (Tyrosine-protein kinase 1) Length = 1584 Score = 65.9 bits (159), Expect = 6e-11 Identities = 43/96 (44%), Positives = 50/96 (52%) Frame = +3 Query: 147 DLEELRELGSGTFGTVYHGKWRGTDVAIKRIKKSCFTGRSSEQERLAQEFWREAEILSKL 326 +LE + +G G FG V G WR TDVAIK I + F +SS F E ILSKL Sbjct: 1288 ELEFGQTIGKGFFGEVKRGYWRETDVAIKIIYRDQFKTKSS-----LVMFQNEVGILSKL 1342 Query: 327 HHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVL 434 HPNVV F G G +TE+M GSLR L Sbjct: 1343 RHPNVVQFLGACTAGGEDHHCIVTEWMGGGSLRQFL 1378
>BTK_HUMAN (Q06187) Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton's| tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) Length = 658 Score = 65.9 bits (159), Expect = 6e-11 Identities = 45/103 (43%), Positives = 59/103 (57%), Gaps = 2/103 (1%) Frame = +3 Query: 135 IKNEDLEELRELGSGTFGTVYHGKWRGT-DVAIKRIKKSCFTGRSSEQERLAQEFWREAE 311 I +DL L+ELG+G FG V +GKWRG DVAIK IK+ G SE EF EA+ Sbjct: 396 IDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKE----GSMSE-----DEFIEEAK 446 Query: 312 ILSKLHHPNVVAFYGV-VKDGPGGTLATLTEFMVNGSLRHVLQ 437 ++ L H +V YGV K P + +TE+M NG L + L+ Sbjct: 447 VMMNLSHEKLVQLYGVCTKQRP---IFIITEYMANGCLLNYLR 486
>YR831_MIMIV (Q7T6Y2) Putative serine/threonine-protein kinase/receptor R831| precursor (EC 2.7.11.1) Length = 1624 Score = 65.5 bits (158), Expect = 7e-11 Identities = 38/102 (37%), Positives = 60/102 (58%) Frame = +3 Query: 132 IIKNEDLEELRELGSGTFGTVYHGKWRGTDVAIKRIKKSCFTGRSSEQERLAQEFWREAE 311 II +++ +++G G++G V++GKW+G DVA+K+ K + SE + L EF E Sbjct: 1358 IINYDEISIGKQIGLGSYGIVFNGKWKGVDVAVKKFVKQ----KLSETQLL--EFRAEMA 1411 Query: 312 ILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQ 437 LS+L H N+V F G P + +TE+M G+LR VL+ Sbjct: 1412 FLSELKHSNIVTFIGACIKKP--NICIVTEYMRMGNLRDVLK 1451 Score = 58.9 bits (141), Expect = 7e-09 Identities = 40/111 (36%), Positives = 57/111 (51%) Frame = +3 Query: 147 DLEELRELGSGTFGTVYHGKWRGTDVAIKRIKKSCFTGRSSEQERLAQEFWREAEILSKL 326 +LE LG+G +G VY W+GT+VA+K I S + ER F+ E +I++ L Sbjct: 785 ELEIGETLGTGGYGEVYKSIWKGTEVAVKLISSKHV---SKDMER---SFFEEVKIMTSL 838 Query: 327 HHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQRKGQCPDLPQRLII 479 HPNVV F P + + EFM GSL +L + P++P L I Sbjct: 839 RHPNVVLFMAASTKSP--NMCIVMEFMSLGSLYDLLGNE-LIPEIPYALKI 886
>BTK_MOUSE (P35991) Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton's| tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB) Length = 658 Score = 64.7 bits (156), Expect = 1e-10 Identities = 44/103 (42%), Positives = 59/103 (57%), Gaps = 2/103 (1%) Frame = +3 Query: 135 IKNEDLEELRELGSGTFGTVYHGKWRGT-DVAIKRIKKSCFTGRSSEQERLAQEFWREAE 311 I +DL L+ELG+G FG V +GKWRG DVAIK I++ G SE EF EA+ Sbjct: 396 IDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIRE----GSMSE-----DEFIEEAK 446 Query: 312 ILSKLHHPNVVAFYGV-VKDGPGGTLATLTEFMVNGSLRHVLQ 437 ++ L H +V YGV K P + +TE+M NG L + L+ Sbjct: 447 VMMNLSHEKLVQLYGVCTKQRP---IFIITEYMANGCLLNYLR 486
>CSK_RAT (P32577) Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase)| Length = 450 Score = 64.7 bits (156), Expect = 1e-10 Identities = 44/133 (33%), Positives = 67/133 (50%) Frame = +3 Query: 51 EPKFEEDRTAAQVMDASLRDSDFEHLQIIKNEDLEELRELGSGTFGTVYHGKWRGTDVAI 230 +PK E AAQ D + + ++L+ L+ +G G FG V G +RG VA+ Sbjct: 169 KPKVMEGTVAAQ-------DEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAV 221 Query: 231 KRIKKSCFTGRSSEQERLAQEFWREAEILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMV 410 K IK + AQ F EA ++++L H N+V GV+ + GG L +TE+M Sbjct: 222 KCIKN----------DATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGG-LYIVTEYMA 270 Query: 411 NGSLRHVLQRKGQ 449 GSL L+ +G+ Sbjct: 271 KGSLVDYLRSRGR 283
>CSK_MOUSE (P41241) Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase)| (Protein-tyrosine kinase MPK-2) (p50CSK) Length = 450 Score = 64.7 bits (156), Expect = 1e-10 Identities = 44/133 (33%), Positives = 67/133 (50%) Frame = +3 Query: 51 EPKFEEDRTAAQVMDASLRDSDFEHLQIIKNEDLEELRELGSGTFGTVYHGKWRGTDVAI 230 +PK E AAQ D + + ++L+ L+ +G G FG V G +RG VA+ Sbjct: 169 KPKVMEGTVAAQ-------DEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAV 221 Query: 231 KRIKKSCFTGRSSEQERLAQEFWREAEILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMV 410 K IK + AQ F EA ++++L H N+V GV+ + GG L +TE+M Sbjct: 222 KCIKN----------DATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGG-LYIVTEYMA 270 Query: 411 NGSLRHVLQRKGQ 449 GSL L+ +G+ Sbjct: 271 KGSLVDYLRSRGR 283
>CSK_HUMAN (P41240) Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase)| (Protein-tyrosine kinase CYL) Length = 450 Score = 64.7 bits (156), Expect = 1e-10 Identities = 44/133 (33%), Positives = 67/133 (50%) Frame = +3 Query: 51 EPKFEEDRTAAQVMDASLRDSDFEHLQIIKNEDLEELRELGSGTFGTVYHGKWRGTDVAI 230 +PK E AAQ D + + ++L+ L+ +G G FG V G +RG VA+ Sbjct: 169 KPKVMEGTVAAQ-------DEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAV 221 Query: 231 KRIKKSCFTGRSSEQERLAQEFWREAEILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMV 410 K IK + AQ F EA ++++L H N+V GV+ + GG L +TE+M Sbjct: 222 KCIKN----------DATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGG-LYIVTEYMA 270 Query: 411 NGSLRHVLQRKGQ 449 GSL L+ +G+ Sbjct: 271 KGSLVDYLRSRGR 283
>BTK_CHICK (Q8JH64) Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton's| tyrosine kinase) Length = 657 Score = 62.4 bits (150), Expect = 6e-10 Identities = 47/114 (41%), Positives = 64/114 (56%), Gaps = 5/114 (4%) Frame = +3 Query: 135 IKNEDLEELRELGSGTFGTVYHGKWRGT-DVAIKRIKKSCFTGRSSEQERLAQEFWREAE 311 I +DL L+ELG+G FG V +GKWRG +VAIK I++ G SE EF EA+ Sbjct: 395 IDPKDLTFLKELGTGQFGVVKYGKWRGQYNVAIKMIRE----GSMSE-----DEFIDEAK 445 Query: 312 ILSKLHHPNVVAFYGV-VKDGPGGTLATLTEFMVNGSLRHVL---QRKGQCPDL 461 ++ L H +V YGV K P + +TE+M NG L + L QR+ Q +L Sbjct: 446 VMMNLSHEKLVQLYGVCTKQRP---IFIITEYMANGCLLNFLRETQRRFQPAEL 496
>CSK_CHICK (P41239) Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase)| Length = 450 Score = 61.2 bits (147), Expect = 1e-09 Identities = 44/133 (33%), Positives = 65/133 (48%) Frame = +3 Query: 51 EPKFEEDRTAAQVMDASLRDSDFEHLQIIKNEDLEELRELGSGTFGTVYHGKWRGTDVAI 230 +PK E AAQ D + +DL+ L+ +G G FG V G +RG VA+ Sbjct: 169 KPKVMEGTVAAQ-------DEFSRSGWALNMKDLKLLQIIGKGEFGDVMLGDYRGNKVAV 221 Query: 231 KRIKKSCFTGRSSEQERLAQEFWREAEILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMV 410 K IK + AQ F EA ++++L H N+V GV+ + G L +TE+M Sbjct: 222 KCIK----------NDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKSG-LYIVTEYMA 270 Query: 411 NGSLRHVLQRKGQ 449 GSL L+ +G+ Sbjct: 271 KGSLVDYLRSRGR 283
>SRK4_SPOLA (P42690) Tyrosine-protein kinase isoform SRK4 (EC 2.7.10.2)| Length = 506 Score = 60.8 bits (146), Expect = 2e-09 Identities = 39/112 (34%), Positives = 59/112 (52%), Gaps = 2/112 (1%) Frame = +3 Query: 135 IKNEDLEELRELGSGTFGTVYHGKWRG-TDVAIKRIKKSCFTGRSSEQERLAQEFWREAE 311 I+ + ++ LR LG+G FG V+ G W G T VA+K +K + +EF EA Sbjct: 235 IEKKQIKLLRGLGAGQFGEVWEGLWNGTTSVAVKTLKPGTMS---------IEEFLEEAS 285 Query: 312 ILSKLHHPNVVAFYGV-VKDGPGGTLATLTEFMVNGSLRHVLQRKGQCPDLP 464 I+ +L HP ++ Y V K+ P + +TE M +GSL L+ G+ LP Sbjct: 286 IMKQLRHPKLIQLYAVCTKEEP---IYIVTELMKHGSLLEYLRGDGRSLKLP 334
>YRK_CHICK (Q02977) Proto-oncogene tyrosine-protein kinase Yrk (EC 2.7.10.2)| (p60-Yrk) (Yes-related kinase) Length = 535 Score = 60.8 bits (146), Expect = 2e-09 Identities = 42/118 (35%), Positives = 62/118 (52%), Gaps = 2/118 (1%) Frame = +3 Query: 135 IKNEDLEELRELGSGTFGTVYHGKWRG-TDVAIKRIKKSCFTGRSSEQERLAQEFWREAE 311 I E L+ L++LG+G FG V+ G W G T VA+K +K + + F EA+ Sbjct: 264 IPRESLQLLQKLGNGQFGEVWMGTWNGTTKVAVKTLKPGTMS---------PEAFLEEAQ 314 Query: 312 ILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQ-RKGQCPDLPQRLIIA 482 I+ +L H +V Y VV + P + +TEFM GSL L+ G+ LPQ + +A Sbjct: 315 IMKRLRHDKLVQLYAVVSEEP---IYIVTEFMSQGSLLDFLKDGDGRYLKLPQLVDMA 369
>FYN_XIPHE (P27446) Proto-oncogene tyrosine-protein kinase FYN (EC 2.7.10.2)| (P59-FYN) Length = 536 Score = 60.5 bits (145), Expect = 2e-09 Identities = 41/118 (34%), Positives = 61/118 (51%), Gaps = 2/118 (1%) Frame = +3 Query: 135 IKNEDLEELRELGSGTFGTVYHGKWRG-TDVAIKRIKKSCFTGRSSEQERLAQEFWREAE 311 I E L+ ++ LG+G FG V+ G W G T VA+K +K + S F EA+ Sbjct: 265 IPRESLQLIKRLGNGQFGEVWMGTWNGTTKVAVKTLKPGTMSPES---------FLEEAQ 315 Query: 312 ILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQ-RKGQCPDLPQRLIIA 482 I+ KL H +V Y VV + P + +TE+M GSL L+ +G+ LP + +A Sbjct: 316 IMKKLRHDKLVQLYAVVSEEP---IYIVTEYMSKGSLLDFLKDGEGRALKLPNLVDMA 370
>FYN_XENLA (P13406) Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2)| (p59-Fyn) Length = 536 Score = 60.5 bits (145), Expect = 2e-09 Identities = 42/118 (35%), Positives = 61/118 (51%), Gaps = 2/118 (1%) Frame = +3 Query: 135 IKNEDLEELRELGSGTFGTVYHGKWRG-TDVAIKRIKKSCFTGRSSEQERLAQEFWREAE 311 I E L+ ++ LG+G FG V+ G W G T VAIK +K + S F EA+ Sbjct: 265 IPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPES---------FLEEAQ 315 Query: 312 ILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQ-RKGQCPDLPQRLIIA 482 I+ KL H +V Y VV + P + +TE+M GSL L+ +G+ LP + +A Sbjct: 316 IMKKLKHDKLVQLYAVVSEEP---IYIVTEYMSKGSLLDFLKDGEGRALKLPNLVDMA 370
>SRK2_SPOLA (P42688) Tyrosine-protein kinase SRK2 (EC 2.7.10.2) (Fragment)| Length = 362 Score = 60.1 bits (144), Expect = 3e-09 Identities = 39/117 (33%), Positives = 56/117 (47%), Gaps = 1/117 (0%) Frame = +3 Query: 135 IKNEDLEELRELGSGTFGTVYHGKW-RGTDVAIKRIKKSCFTGRSSEQERLAQEFWREAE 311 I + + +R+LG+G FG VY G W T VA+K +K + F EA+ Sbjct: 90 ISRDSITLIRKLGAGQFGEVYQGLWNNSTPVAVKTLKAGTMQPAA---------FLAEAQ 140 Query: 312 ILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQRKGQCPDLPQRLIIA 482 I+ KL HP ++ Y V G + +TE M GSL LQ + LPQ + +A Sbjct: 141 IMKKLRHPKLIQLYAVCTQGE--PVYIITELMSKGSLLDYLQGEAGALKLPQLIDMA 195
>YES_CHICK (P09324) Tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes)| Length = 540 Score = 60.1 bits (144), Expect = 3e-09 Identities = 43/118 (36%), Positives = 60/118 (50%), Gaps = 2/118 (1%) Frame = +3 Query: 135 IKNEDLEELRELGSGTFGTVYHGKWRG-TDVAIKRIKKSCFTGRSSEQERLAQEFWREAE 311 I E L +LG G FG V+ G W G T VAIK +K + + F +EA+ Sbjct: 269 IPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTM---------MPEAFLQEAQ 319 Query: 312 ILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQR-KGQCPDLPQRLIIA 482 I+ KL H +V Y VV + P + +TEFM GSL L+ +G+ LPQ + +A Sbjct: 320 IMKKLRHDKLVPLYAVVSEEP---IYIVTEFMTKGSLLDFLKEGEGKFLKLPQLVDMA 374
>FYN_HUMAN (P06241) Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2)| (p59-Fyn) (Protooncogene Syn) (SLK) Length = 536 Score = 60.1 bits (144), Expect = 3e-09 Identities = 42/118 (35%), Positives = 61/118 (51%), Gaps = 2/118 (1%) Frame = +3 Query: 135 IKNEDLEELRELGSGTFGTVYHGKWRG-TDVAIKRIKKSCFTGRSSEQERLAQEFWREAE 311 I E L+ ++ LG+G FG V+ G W G T VAIK +K + S F EA+ Sbjct: 265 IPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPES---------FLEEAQ 315 Query: 312 ILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQ-RKGQCPDLPQRLIIA 482 I+ KL H +V Y VV + P + +TE+M GSL L+ +G+ LP + +A Sbjct: 316 IMKKLKHDKLVQLYAVVSEEP---IYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMA 370
>SPK1_DUGTI (P42687) Tyrosine-protein kinase SPK-1 (EC 2.7.10.2)| Length = 497 Score = 59.7 bits (143), Expect = 4e-09 Identities = 37/102 (36%), Positives = 57/102 (55%), Gaps = 1/102 (0%) Frame = +3 Query: 135 IKNEDLEELRELGSGTFGTVYHGKW-RGTDVAIKRIKKSCFTGRSSEQERLAQEFWREAE 311 I E++E L E+G G FG+V+ KW R +VA K ++ SS+ ER ++F EA+ Sbjct: 215 INRENIEILNEIGRGFFGSVHRAKWGRSYEVAAKMLQ-------SSKAER--EKFVLEAK 265 Query: 312 ILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQ 437 I+ KL H +V GV + + + E+M NGSL+ L+ Sbjct: 266 IMHKLRHRKIVELLGVCTEPQDMPMLIIVEYMKNGSLKEYLK 307
>YES_AVISY (P00527) Tyrosine-protein kinase transforming protein YES (EC| 2.7.10.2) (Fragment) Length = 528 Score = 59.7 bits (143), Expect = 4e-09 Identities = 43/118 (36%), Positives = 60/118 (50%), Gaps = 2/118 (1%) Frame = +3 Query: 135 IKNEDLEELRELGSGTFGTVYHGKWRG-TDVAIKRIKKSCFTGRSSEQERLAQEFWREAE 311 I E L +LG G FG V+ G W G T VAIK +K + + F +EA+ Sbjct: 262 IPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKLGTM---------MPEAFLQEAQ 312 Query: 312 ILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQR-KGQCPDLPQRLIIA 482 I+ KL H +V Y VV + P + +TEFM GSL L+ +G+ LPQ + +A Sbjct: 313 IMKKLRHDKLVPLYAVVSEEP---IYIVTEFMTKGSLLDFLKEGEGKFLKLPQLVDMA 367
>TXK_MOUSE (P42682) Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18)| (Resting lymphocyte kinase) Length = 527 Score = 59.3 bits (142), Expect = 5e-09 Identities = 44/108 (40%), Positives = 61/108 (56%), Gaps = 3/108 (2%) Frame = +3 Query: 135 IKNEDLEELRELGSGTFGTVYHGKWRG-TDVAIKRIKKSCFTGRSSEQERLAQEFWREAE 311 I +L ++E+GSG FG V+ G+WR VAIK I + G SE ++F EA+ Sbjct: 266 IDPSELAFVKEIGSGQFGVVHLGEWRAHIPVAIKAINE----GSMSE-----EDFIEEAK 316 Query: 312 ILSKLHHPNVVAFYGV-VKDGPGGTLATLTEFMVNGSLRHVL-QRKGQ 449 ++ KL H +V YGV ++ P L +TEFM NG L L +RKGQ Sbjct: 317 VMMKLSHSRLVQLYGVCIQQKP---LYIVTEFMENGCLLDYLRERKGQ 361
>ARAF_HUMAN (P10398) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (A-raf-1) (Proto-oncogene Pks) Length = 606 Score = 59.3 bits (142), Expect = 5e-09 Identities = 46/150 (30%), Positives = 74/150 (49%) Frame = +3 Query: 33 PAPDFEEPKFEEDRTAAQVMDASLRDSDFEHLQIIKNEDLEELRELGSGTFGTVYHGKWR 212 PA E +D+ +V + RDS + + +++ L+ +G+G+FGTV+ G+W Sbjct: 275 PAEQRERKSLADDKK--KVKNLGYRDSGY--YWEVPPSEVQLLKRIGTGSFGTVFRGRWH 330 Query: 213 GTDVAIKRIKKSCFTGRSSEQERLAQEFWREAEILSKLHHPNVVAFYGVVKDGPGGTLAT 392 G DVA+K +K S T AQ F E ++L K H N++ F G + PG A Sbjct: 331 G-DVAVKVLKVSQPTAEQ------AQAFKNEMQVLRKTRHVNILLFMGFM-TRPG--FAI 380 Query: 393 LTEFMVNGSLRHVLQRKGQCPDLPQRLIIA 482 +T++ SL H L D+ Q + +A Sbjct: 381 ITQWCEGSSLYHHLHVADTRFDMVQLIDVA 410
>KYK2_DICDI (P18161) Tyrosine-protein kinase 2 (EC 2.7.10.2) (Fragment)| Length = 410 Score = 58.9 bits (141), Expect = 7e-09 Identities = 34/105 (32%), Positives = 55/105 (52%) Frame = +3 Query: 120 EHLQIIKNEDLEELRELGSGTFGTVYHGKWRGTDVAIKRIKKSCFTGRSSEQERLAQEFW 299 E II D++ ++++G G F V+ G W+G VAIK++K ++E+ + F Sbjct: 98 EREYIIDINDIQFIQKVGEGAFSEVWEGWWKGIHVAIKKLK------IIGDEEQFKERFI 151 Query: 300 REAEILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVL 434 RE + L K +H N+V F G +TE+M GSL ++L Sbjct: 152 REVQNLKKGNHQNIVMFIGACYK----PACIITEYMAGGSLYNIL 192
>YES_XENLA (P10936) Tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes)| Length = 536 Score = 58.9 bits (141), Expect = 7e-09 Identities = 42/118 (35%), Positives = 60/118 (50%), Gaps = 2/118 (1%) Frame = +3 Query: 135 IKNEDLEELRELGSGTFGTVYHGKWRG-TDVAIKRIKKSCFTGRSSEQERLAQEFWREAE 311 I E L +LG G FG V+ G W G T VAIK +K + + F +EA+ Sbjct: 265 IPRESLRLDVKLGQGCFGEVWIGTWNGTTKVAIKTLKPGTM---------MPEAFLQEAQ 315 Query: 312 ILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQR-KGQCPDLPQRLIIA 482 I+ KL H +V Y VV + P + +TE+M+ GSL L+ G+ LPQ + +A Sbjct: 316 IMKKLRHDKLVPLYAVVSEEP---IYIVTEYMIKGSLLDFLKEGNGKYLKLPQLVDMA 370
>ARAF_RAT (P14056) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) Length = 604 Score = 58.9 bits (141), Expect = 7e-09 Identities = 45/154 (29%), Positives = 77/154 (50%) Frame = +3 Query: 21 NTNLPAPDFEEPKFEEDRTAAQVMDASLRDSDFEHLQIIKNEDLEELRELGSGTFGTVYH 200 ++ LPA E +++ +V + RDS + + +++ L+ +G+G+FGTV+ Sbjct: 269 HSKLPAEQRERKSLADEKK--KVKNLGYRDSGY--YWEVPPSEVQLLKRIGTGSFGTVFR 324 Query: 201 GKWRGTDVAIKRIKKSCFTGRSSEQERLAQEFWREAEILSKLHHPNVVAFYGVVKDGPGG 380 G+W G DVA+K +K + T AQ F E ++L K H N++ F G + PG Sbjct: 325 GRWHG-DVAVKVLKVAQPTAEQ------AQAFKNEMQVLRKTRHVNILLFMGFM-TRPG- 375 Query: 381 TLATLTEFMVNGSLRHVLQRKGQCPDLPQRLIIA 482 A +T++ SL H L D+ Q + +A Sbjct: 376 -FAIITQWCEGSSLYHHLHVADTRFDMVQLIDVA 408
>RAF1_XENLA (P09560) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (C-RAF) Length = 638 Score = 58.9 bits (141), Expect = 7e-09 Identities = 53/148 (35%), Positives = 73/148 (49%), Gaps = 5/148 (3%) Frame = +3 Query: 21 NTNLPAPDFEEPKFEED-RTAAQVMDASLRDSDFEHLQIIKNEDLEELRELGSGTFGTVY 197 N PAP E + ++ RDS + + +II +E + R +GSG+FGTVY Sbjct: 298 NAKAPAPTHREKAASSTGQEKNKIRARGQRDSSY-YWEIIASEVMLSSR-IGSGSFGTVY 355 Query: 198 HGKWRGTDVAIKRIKKSCFTGRSSEQERLAQEFWREAEILSKLHHPNVVAFYG-VVKDGP 374 GKW G DVA+K +K T + EQ Q F E +L K H N++ F G + KD Sbjct: 356 KGKWHG-DVAVKILK---VTDPTPEQ---LQAFRNEVAVLRKTRHVNILLFMGYMTKD-- 406 Query: 375 GGTLATLTEFMVNGSL---RHVLQRKGQ 449 LA +T++ SL HVL K Q Sbjct: 407 --NLAIVTQWCEGSSLYYHLHVLDTKFQ 432
>TEC_HUMAN (P42680) Tyrosine-protein kinase Tec (EC 2.7.10.2)| Length = 631 Score = 58.5 bits (140), Expect = 9e-09 Identities = 42/106 (39%), Positives = 55/106 (51%), Gaps = 2/106 (1%) Frame = +3 Query: 135 IKNEDLEELRELGSGTFGTVYHGKWRGT-DVAIKRIKKSCFTGRSSEQERLAQEFWREAE 311 I +L +RELGSG FG V GKWR VAIK I+ E ++F EA+ Sbjct: 365 INPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIR---------EGAMCEEDFIEEAK 415 Query: 312 ILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVL-QRKG 446 ++ KL HP +V YGV + +TEFM G L + L QR+G Sbjct: 416 VMMKLTHPKLVQLYGVCTQQK--PIYIVTEFMERGCLLNFLRQRQG 459
>YES_HUMAN (P07947) Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2)| (p61-Yes) (c-Yes) Length = 542 Score = 58.5 bits (140), Expect = 9e-09 Identities = 43/118 (36%), Positives = 59/118 (50%), Gaps = 2/118 (1%) Frame = +3 Query: 135 IKNEDLEELRELGSGTFGTVYHGKWRG-TDVAIKRIKKSCFTGRSSEQERLAQEFWREAE 311 I E L +LG G FG V+ G W G T VAIK +K + + F +EA+ Sbjct: 271 IPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTM---------MPEAFLQEAQ 321 Query: 312 ILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQR-KGQCPDLPQRLIIA 482 I+ KL H +V Y VV + P + +TEFM GSL L+ G+ LPQ + +A Sbjct: 322 IMKKLRHDKLVPLYAVVSEEP---IYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMA 376
>YES_MOUSE (Q04736) Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2)| (p61-Yes) (c-Yes) Length = 540 Score = 58.5 bits (140), Expect = 9e-09 Identities = 43/118 (36%), Positives = 59/118 (50%), Gaps = 2/118 (1%) Frame = +3 Query: 135 IKNEDLEELRELGSGTFGTVYHGKWRG-TDVAIKRIKKSCFTGRSSEQERLAQEFWREAE 311 I E L +LG G FG V+ G W G T VAIK +K + + F +EA+ Sbjct: 269 IPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTM---------MPEAFLQEAQ 319 Query: 312 ILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQR-KGQCPDLPQRLIIA 482 I+ KL H +V Y VV + P + +TEFM GSL L+ G+ LPQ + +A Sbjct: 320 IMKKLRHDKLVPLYAVVSEEP---IYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMA 374
>TEC_MOUSE (P24604) Tyrosine-protein kinase Tec (EC 2.7.10.2)| Length = 630 Score = 58.5 bits (140), Expect = 9e-09 Identities = 42/106 (39%), Positives = 55/106 (51%), Gaps = 2/106 (1%) Frame = +3 Query: 135 IKNEDLEELRELGSGTFGTVYHGKWRGT-DVAIKRIKKSCFTGRSSEQERLAQEFWREAE 311 I +L +RELGSG FG V GKWR VAIK I+ E ++F EA+ Sbjct: 364 INPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIR---------EGAMCEEDFIEEAK 414 Query: 312 ILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVL-QRKG 446 ++ KL HP +V YGV + +TEFM G L + L QR+G Sbjct: 415 VMMKLTHPKLVQLYGVCTQQK--PIYIVTEFMERGCLLNFLRQRQG 458
>FGR_FSVGR (P00544) Tyrosine-protein kinase transforming protein Fgr (EC| 2.7.10.2) Length = 545 Score = 58.2 bits (139), Expect = 1e-08 Identities = 40/109 (36%), Positives = 60/109 (55%), Gaps = 2/109 (1%) Frame = +3 Query: 162 RELGSGTFGTVYHGKWRG-TDVAIKRIKKSCFTGRSSEQERLAQEFWREAEILSKLHHPN 338 R LG+G FG V+ G W G T VA+K +K + ++S + EA+I+ L H Sbjct: 290 RRLGTGCFGDVWLGMWNGSTKVAVKTLKPGTMSPKASLE---------EAQIMKLLRHDK 340 Query: 339 VVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQ-RKGQCPDLPQRLIIA 482 +V Y VV + P + +TEFM +GSL L+ ++GQ LPQ + +A Sbjct: 341 LVQLYAVVPEEP---IYIVTEFMCHGSLLEFLKDQEGQDLTLPQLVDMA 386
>IRAK1_MOUSE (Q62406) Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1)| (IRAK-1) (IRAK) (Pelle-like protein kinase) (mPLK) Length = 710 Score = 58.2 bits (139), Expect = 1e-08 Identities = 44/112 (39%), Positives = 55/112 (49%), Gaps = 3/112 (2%) Frame = +3 Query: 153 EELRELGSGTFGTVYHGKWRGTDVAIKRIKKSCFTGRSSEQERLAQEFWREAEILSKLHH 332 EELR +G G FG VY R T A+KR+K+ E + Q F E E LS+ H Sbjct: 214 EELR-IGEGGFGCVYRAVMRNTTYAVKRLKEEA----DLEWTMVKQSFLTEVEQLSRFRH 268 Query: 333 PNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQRKGQ-CPDL--PQRLII 479 PN+V F G + G + F+ NGSL L + Q C L PQRL I Sbjct: 269 PNIVDFAGYCAE--SGLYCLVYGFLPNGSLEDQLHLQTQACSPLSWPQRLDI 318
>YES_CANFA (Q28923) Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2)| (p61-Yes) (c-Yes) Length = 538 Score = 58.2 bits (139), Expect = 1e-08 Identities = 43/118 (36%), Positives = 59/118 (50%), Gaps = 2/118 (1%) Frame = +3 Query: 135 IKNEDLEELRELGSGTFGTVYHGKWRG-TDVAIKRIKKSCFTGRSSEQERLAQEFWREAE 311 I E L +LG G FG V+ G W G T VAIK +K + + F +EA+ Sbjct: 267 IPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKLGTM---------MPEAFLQEAQ 317 Query: 312 ILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQR-KGQCPDLPQRLIIA 482 I+ KL H +V Y VV + P + +TEFM GSL L+ G+ LPQ + +A Sbjct: 318 IMKKLRHDKLVPLYAVVSEEP---IYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMA 372
>NTRK3_RAT (Q03351) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C) Length = 864 Score = 57.8 bits (138), Expect = 1e-08 Identities = 39/115 (33%), Positives = 56/115 (48%), Gaps = 7/115 (6%) Frame = +3 Query: 123 HLQIIKNEDLEELRELGSGTFGTVYHGKWRGTD-------VAIKRIKKSCFTGRSSEQER 281 ++Q IK D+ RELG G FG V+ + VA+K +K R Sbjct: 529 YVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAAR------ 582 Query: 282 LAQEFWREAEILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQRKG 446 ++F REAE+L+ L H ++V FYGV G G L + E+M +G L L+ G Sbjct: 583 --KDFQREAELLTNLQHEHIVKFYGVC--GDGDPLIMVFEYMKHGDLNKFLRAHG 633
>NTRK3_HUMAN (Q16288) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C) Length = 839 Score = 57.8 bits (138), Expect = 1e-08 Identities = 39/115 (33%), Positives = 56/115 (48%), Gaps = 7/115 (6%) Frame = +3 Query: 123 HLQIIKNEDLEELRELGSGTFGTVYHGKWRGTD-------VAIKRIKKSCFTGRSSEQER 281 ++Q IK D+ RELG G FG V+ + VA+K +K R Sbjct: 529 YVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAAR------ 582 Query: 282 LAQEFWREAEILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQRKG 446 ++F REAE+L+ L H ++V FYGV G G L + E+M +G L L+ G Sbjct: 583 --KDFQREAELLTNLQHEHIVKFYGVC--GDGDPLIMVFEYMKHGDLNKFLRAHG 633
>IRAK1_HUMAN (P51617) Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1)| (IRAK-1) Length = 712 Score = 57.8 bits (138), Expect = 1e-08 Identities = 44/112 (39%), Positives = 56/112 (50%), Gaps = 3/112 (2%) Frame = +3 Query: 153 EELRELGSGTFGTVYHGKWRGTDVAIKRIKKSCFTGRSSEQERLAQEFWREAEILSKLHH 332 EEL+ +G G FG VY R T A+KR+K++ E + Q F E E LS+ H Sbjct: 214 EELK-IGEGGFGCVYRAVMRNTVYAVKRLKENA----DLEWTAVKQSFLTEVEQLSRFRH 268 Query: 333 PNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQRKGQ-CPDL--PQRLII 479 PN+V F G G + F+ NGSL L + Q CP L PQRL I Sbjct: 269 PNIVDFAGYC--AQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDI 318
>NTRK3_SAIBB (Q5IS82) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) Length = 825 Score = 57.8 bits (138), Expect = 1e-08 Identities = 39/115 (33%), Positives = 56/115 (48%), Gaps = 7/115 (6%) Frame = +3 Query: 123 HLQIIKNEDLEELRELGSGTFGTVYHGKWRGTD-------VAIKRIKKSCFTGRSSEQER 281 ++Q IK D+ RELG G FG V+ + VA+K +K R Sbjct: 529 YVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAAR------ 582 Query: 282 LAQEFWREAEILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQRKG 446 ++F REAE+L+ L H ++V FYGV G G L + E+M +G L L+ G Sbjct: 583 --KDFQREAELLTNLQHEHIVKFYGVC--GDGDPLIMVFEYMKHGDLNKFLRAHG 633
>NTRK3_PIG (P24786) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C) Length = 825 Score = 57.8 bits (138), Expect = 1e-08 Identities = 39/115 (33%), Positives = 56/115 (48%), Gaps = 7/115 (6%) Frame = +3 Query: 123 HLQIIKNEDLEELRELGSGTFGTVYHGKWRGTD-------VAIKRIKKSCFTGRSSEQER 281 ++Q IK D+ RELG G FG V+ + VA+K +K R Sbjct: 529 YVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKVKMLVAVKALKDPTLAAR------ 582 Query: 282 LAQEFWREAEILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQRKG 446 ++F REAE+L+ L H ++V FYGV G G L + E+M +G L L+ G Sbjct: 583 --KDFQREAELLTNLQHEHIVKFYGVC--GDGDPLIMVFEYMKHGDLNKFLRAHG 633
>NTRK3_PANTR (Q5IS37) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) Length = 825 Score = 57.8 bits (138), Expect = 1e-08 Identities = 39/115 (33%), Positives = 56/115 (48%), Gaps = 7/115 (6%) Frame = +3 Query: 123 HLQIIKNEDLEELRELGSGTFGTVYHGKWRGTD-------VAIKRIKKSCFTGRSSEQER 281 ++Q IK D+ RELG G FG V+ + VA+K +K R Sbjct: 529 YVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAAR------ 582 Query: 282 LAQEFWREAEILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQRKG 446 ++F REAE+L+ L H ++V FYGV G G L + E+M +G L L+ G Sbjct: 583 --KDFQREAELLTNLQHEHIVKFYGVC--GDGDPLIMVFEYMKHGDLNKFLRAHG 633
>NTRK3_MACFA (Q5IFJ9) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) Length = 825 Score = 57.8 bits (138), Expect = 1e-08 Identities = 39/115 (33%), Positives = 56/115 (48%), Gaps = 7/115 (6%) Frame = +3 Query: 123 HLQIIKNEDLEELRELGSGTFGTVYHGKWRGTD-------VAIKRIKKSCFTGRSSEQER 281 ++Q IK D+ RELG G FG V+ + VA+K +K R Sbjct: 529 YVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAAR------ 582 Query: 282 LAQEFWREAEILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQRKG 446 ++F REAE+L+ L H ++V FYGV G G L + E+M +G L L+ G Sbjct: 583 --KDFQREAELLTNLQHEHIVKFYGVC--GDGDPLIMVFEYMKHGDLNKFLRAHG 633
>NTRK3_CHICK (Q91044) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (Trk-C) Length = 827 Score = 57.8 bits (138), Expect = 1e-08 Identities = 39/115 (33%), Positives = 56/115 (48%), Gaps = 7/115 (6%) Frame = +3 Query: 123 HLQIIKNEDLEELRELGSGTFGTVYHGKWRGTD-------VAIKRIKKSCFTGRSSEQER 281 ++Q IK D+ RELG G FG V+ + VA+K +K R Sbjct: 531 YVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTNDKMLVAVKALKDPTLAAR------ 584 Query: 282 LAQEFWREAEILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQRKG 446 ++F REAE+L+ L H ++V FYGV G G L + E+M +G L L+ G Sbjct: 585 --KDFQREAELLTNLQHEHIVKFYGVC--GDGDPLIMVFEYMKHGDLNKFLRAHG 635
>ARAF_MOUSE (P04627) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) Length = 604 Score = 57.8 bits (138), Expect = 1e-08 Identities = 44/154 (28%), Positives = 77/154 (50%) Frame = +3 Query: 21 NTNLPAPDFEEPKFEEDRTAAQVMDASLRDSDFEHLQIIKNEDLEELRELGSGTFGTVYH 200 ++ LP+ E +++ +V + RDS + + +++ L+ +G+G+FGTV+ Sbjct: 269 HSKLPSEQRERKSLADEKK--KVKNLGYRDSGY--YWEVPPSEVQLLKRIGTGSFGTVFR 324 Query: 201 GKWRGTDVAIKRIKKSCFTGRSSEQERLAQEFWREAEILSKLHHPNVVAFYGVVKDGPGG 380 G+W G DVA+K +K + T AQ F E ++L K H N++ F G + PG Sbjct: 325 GRWHG-DVAVKVLKVAQPTAEQ------AQAFKNEMQVLRKTRHVNILLFMGFM-TRPG- 375 Query: 381 TLATLTEFMVNGSLRHVLQRKGQCPDLPQRLIIA 482 A +T++ SL H L D+ Q + +A Sbjct: 376 -FAIITQWCEGSSLYHHLHVADTRFDMVQLIDVA 408
>M3K7_MOUSE (Q62073) Mitogen-activated protein kinase kinase kinase 7 (EC| 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1) Length = 579 Score = 57.4 bits (137), Expect = 2e-08 Identities = 42/120 (35%), Positives = 66/120 (55%) Frame = +3 Query: 75 TAAQVMDASLRDSDFEHLQIIKNEDLEELRELGSGTFGTVYHGKWRGTDVAIKRIKKSCF 254 +A+++++A + +FE + K ++EE+ +G G FG V KWR DVAIK+I+ Sbjct: 14 SASEMIEAPSQVLNFEEIDY-KEIEVEEV--VGRGAFGVVCKAKWRAKDVAIKQIE---- 66 Query: 255 TGRSSEQERLAQEFWREAEILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVL 434 SE ER A F E LS+++HPN+V YG + + + E+ GSL +VL Sbjct: 67 ----SESERKA--FIVELRQLSRVNHPNIVKLYGACLN----PVCLVMEYAEGGSLYNVL 116
>FGR_HUMAN (P09769) Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2)| (P55-FGR) (C-FGR) Length = 529 Score = 57.4 bits (137), Expect = 2e-08 Identities = 39/109 (35%), Positives = 58/109 (53%), Gaps = 2/109 (1%) Frame = +3 Query: 162 RELGSGTFGTVYHGKWRG-TDVAIKRIKKSCFTGRSSEQERLAQEFWREAEILSKLHHPN 338 R LG+G FG V+ G W G T VA+K +K + ++ F EA+++ L H Sbjct: 267 RRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKA---------FLEEAQVMKLLRHDK 317 Query: 339 VVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQR-KGQCPDLPQRLIIA 482 +V Y VV + P + +TEFM +GSL L+ +GQ LPQ + +A Sbjct: 318 LVQLYAVVSEEP---IYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMA 363
>SRK1_SPOLA (P42686) Tyrosine-protein kinase isoform SRK1 (EC 2.7.10.2)| Length = 505 Score = 57.0 bits (136), Expect = 3e-08 Identities = 36/103 (34%), Positives = 54/103 (52%), Gaps = 2/103 (1%) Frame = +3 Query: 135 IKNEDLEELRELGSGTFGTVYHGKWRG-TDVAIKRIKKSCFTGRSSEQERLAQEFWREAE 311 I+ ++ LR LG+G FG V+ G W G T VA+K +K + +EF +EA Sbjct: 235 IEKTQIKLLRRLGAGQFGEVWEGLWNGTTSVAVKTLKPGTMS---------VEEFLQEAS 285 Query: 312 ILSKLHHPNVVAFYGV-VKDGPGGTLATLTEFMVNGSLRHVLQ 437 I+ +L HP ++ Y V K+ P + +TE M GSL L+ Sbjct: 286 IMKRLRHPKLIQLYAVCTKEEP---IYIVTELMKYGSLLEYLR 325
>M3K7_HUMAN (O43318) Mitogen-activated protein kinase kinase kinase 7 (EC| 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1) Length = 606 Score = 57.0 bits (136), Expect = 3e-08 Identities = 42/120 (35%), Positives = 65/120 (54%) Frame = +3 Query: 75 TAAQVMDASLRDSDFEHLQIIKNEDLEELRELGSGTFGTVYHGKWRGTDVAIKRIKKSCF 254 +A ++++A + +FE + K ++EE+ +G G FG V KWR DVAIK+I+ Sbjct: 14 SAGEMIEAPSQVLNFEEIDY-KEIEVEEV--VGRGAFGVVCKAKWRAKDVAIKQIE---- 66 Query: 255 TGRSSEQERLAQEFWREAEILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVL 434 SE ER A F E LS+++HPN+V YG + + + E+ GSL +VL Sbjct: 67 ----SESERKA--FIVELRQLSRVNHPNIVKLYGACLN----PVCLVMEYAEGGSLYNVL 116
>ARAF_PIG (O19004) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (A-Raf-1) Length = 606 Score = 57.0 bits (136), Expect = 3e-08 Identities = 44/150 (29%), Positives = 74/150 (49%) Frame = +3 Query: 33 PAPDFEEPKFEEDRTAAQVMDASLRDSDFEHLQIIKNEDLEELRELGSGTFGTVYHGKWR 212 P+ E +D+ +V + RDS + + +++ L+ +G+G+FGTV+ G+W Sbjct: 275 PSEQRERKSLADDKK--KVKNLGYRDSGY--YWEVPPSEVQLLKRIGTGSFGTVFRGRWH 330 Query: 213 GTDVAIKRIKKSCFTGRSSEQERLAQEFWREAEILSKLHHPNVVAFYGVVKDGPGGTLAT 392 G DVA+K +K + T AQ F E ++L K H N++ F G + PG A Sbjct: 331 G-DVAVKVLKVAQPTAEQ------AQAFKNEMQVLRKTRHVNILLFMGFM-TRPG--FAI 380 Query: 393 LTEFMVNGSLRHVLQRKGQCPDLPQRLIIA 482 +T++ SL H L D+ Q + +A Sbjct: 381 ITQWCEGSSLYHHLHVADTRFDMVQLIDVA 410
>MLTK_HUMAN (Q9NYL2) Mitogen-activated protein kinase kinase kinase MLT (EC| 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper-and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase Length = 800 Score = 56.6 bits (135), Expect = 3e-08 Identities = 36/98 (36%), Positives = 50/98 (51%), Gaps = 2/98 (2%) Frame = +3 Query: 135 IKNEDLEELRELGSGTFGTVYHGKWRGTD--VAIKRIKKSCFTGRSSEQERLAQEFWREA 308 IK +DL+ G G+FG+VY KW D VA+K++ K +EA Sbjct: 11 IKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLK----------------IEKEA 54 Query: 309 EILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSL 422 EILS L H N++ FYGV+ + P +TE+ GSL Sbjct: 55 EILSVLSHRNIIQFYGVILEPP--NYGIVTEYASLGSL 90
>TXK_HUMAN (P42681) Tyrosine-protein kinase TXK (EC 2.7.10.2)| Length = 527 Score = 56.6 bits (135), Expect = 3e-08 Identities = 42/108 (38%), Positives = 61/108 (56%), Gaps = 3/108 (2%) Frame = +3 Query: 135 IKNEDLEELRELGSGTFGTVYHGKWRG-TDVAIKRIKKSCFTGRSSEQERLAQEFWREAE 311 I +L ++E+GSG FG V+ G+WR VAIK I + G SE ++F EA+ Sbjct: 266 IDPSELAFIKEIGSGQFGVVHLGEWRSHIQVAIKAINE----GSMSE-----EDFIEEAK 316 Query: 312 ILSKLHHPNVVAFYGV-VKDGPGGTLATLTEFMVNGSLRHVL-QRKGQ 449 ++ KL H +V YGV ++ P L +TEFM NG L + L + KG+ Sbjct: 317 VMMKLSHSKLVQLYGVCIQRKP---LYIVTEFMENGCLLNYLRENKGK 361
>MLTK_MOUSE (Q9ESL4) Mitogen-activated protein kinase kinase kinase MLT (EC| 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper-and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) ( Length = 802 Score = 56.6 bits (135), Expect = 3e-08 Identities = 36/98 (36%), Positives = 50/98 (51%), Gaps = 2/98 (2%) Frame = +3 Query: 135 IKNEDLEELRELGSGTFGTVYHGKWRGTD--VAIKRIKKSCFTGRSSEQERLAQEFWREA 308 IK +DL+ G G+FG+VY KW D VA+K++ K +EA Sbjct: 11 IKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLK----------------IEKEA 54 Query: 309 EILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSL 422 EILS L H N++ FYGV+ + P +TE+ GSL Sbjct: 55 EILSVLSHRNIIQFYGVILEPP--NYGIVTEYASLGSL 90
>SRC_AVIST (P14085) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 556 Score = 56.2 bits (134), Expect = 4e-08 Identities = 41/118 (34%), Positives = 59/118 (50%), Gaps = 2/118 (1%) Frame = +3 Query: 135 IKNEDLEELRELGSGTFGTVYHGKWRGTD-VAIKRIKKSCFTGRSSEQERLAQEFWREAE 311 I E L +LG G FG V+ G W GT VAIK +K + + F +EA+ Sbjct: 261 IPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMS---------PEAFLQEAQ 311 Query: 312 ILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQ-RKGQCPDLPQRLIIA 482 ++ KL H +V Y VV + P + +TE+M GSL L+ G+ LPQ + +A Sbjct: 312 VMKKLRHEKLVQLYAVVSEEP---IYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMA 366
>YES_XIPHE (P27447) Tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes)| Length = 543 Score = 56.2 bits (134), Expect = 4e-08 Identities = 43/118 (36%), Positives = 57/118 (48%), Gaps = 2/118 (1%) Frame = +3 Query: 135 IKNEDLEELRELGSGTFGTVYHGKWRG-TDVAIKRIKKSCFTGRSSEQERLAQEFWREAE 311 I E L LG G FG V+ G W G T VAIK +K + + F EA+ Sbjct: 272 IPRESLRLDVRLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMS---------PEAFLEEAQ 322 Query: 312 ILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQR-KGQCPDLPQRLIIA 482 I+ KL H +V Y VV + P + +TEFM GSL L+ G+ LPQ + +A Sbjct: 323 IMKKLRHDKLVPLYAVVSEEP---IYIVTEFMGKGSLLDFLKEGDGKHLKLPQLVDMA 377
>JAK1_BRARE (O12990) Tyrosine-protein kinase Jak1 (EC 2.7.10.2) (Janus kinase 1)| (Jak-1) Length = 1153 Score = 56.2 bits (134), Expect = 4e-08 Identities = 33/109 (30%), Positives = 54/109 (49%), Gaps = 6/109 (5%) Frame = +3 Query: 132 IIKNEDLEELRELGSGTFGTVY------HGKWRGTDVAIKRIKKSCFTGRSSEQERLAQE 293 + + L+++R+LG G FG V G G VA+K +K +E + Sbjct: 866 VFEKRFLKKIRDLGEGHFGKVELCRYDPRGDRTGELVAVKSLKPE-------NREEQSNN 918 Query: 294 FWREAEILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQR 440 WRE IL +L+H N+V + G+ + G ++ + EF+ GSL+ L R Sbjct: 919 LWREIHILRELYHENIVKYKGICNEEGGRSIKLIMEFLPAGSLKEYLPR 967
>M3KL4_HUMAN (Q5TCX8) Mitogen-activated protein kinase kinase kinase (EC| 2.7.11.25) (Mixed lineage kinase 4) Length = 1036 Score = 56.2 bits (134), Expect = 4e-08 Identities = 34/102 (33%), Positives = 49/102 (48%), Gaps = 1/102 (0%) Frame = +3 Query: 156 ELREL-GSGTFGTVYHGKWRGTDVAIKRIKKSCFTGRSSEQERLAQEFWREAEILSKLHH 332 EL+EL G+G FG VY W+G +VA+K ++ + A+ REA + + L H Sbjct: 125 ELKELIGAGGFGQVYRATWQGQEVAVKAARQD----PEQDAAAAAESVRREARLFAMLRH 180 Query: 333 PNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQRKGQCPD 458 PN++ GV P L + EF G+L L PD Sbjct: 181 PNIIELRGVCLQQP--HLCLVLEFARGGALNRALAAANAAPD 220
>SRC_HUMAN (P12931) Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2)| (p60-Src) (c-Src) (pp60c-src) Length = 535 Score = 56.2 bits (134), Expect = 4e-08 Identities = 41/118 (34%), Positives = 59/118 (50%), Gaps = 2/118 (1%) Frame = +3 Query: 135 IKNEDLEELRELGSGTFGTVYHGKWRGTD-VAIKRIKKSCFTGRSSEQERLAQEFWREAE 311 I E L +LG G FG V+ G W GT VAIK +K + + F +EA+ Sbjct: 264 IPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMS---------PEAFLQEAQ 314 Query: 312 ILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQ-RKGQCPDLPQRLIIA 482 ++ KL H +V Y VV + P + +TE+M GSL L+ G+ LPQ + +A Sbjct: 315 VMKKLRHEKLVQLYAVVSEEP---IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMA 369
>SRC_AVISS (P14084) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 567 Score = 56.2 bits (134), Expect = 4e-08 Identities = 41/118 (34%), Positives = 59/118 (50%), Gaps = 2/118 (1%) Frame = +3 Query: 135 IKNEDLEELRELGSGTFGTVYHGKWRGTD-VAIKRIKKSCFTGRSSEQERLAQEFWREAE 311 I E L +LG G FG V+ G W GT VAIK +K + + F +EA+ Sbjct: 261 IPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMS---------PEAFLQEAQ 311 Query: 312 ILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQ-RKGQCPDLPQRLIIA 482 ++ KL H +V Y VV + P + +TE+M GSL L+ G+ LPQ + +A Sbjct: 312 VMKKLRHEKLVRLYAVVSEEP---IYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMA 366
>ITK_MOUSE (Q03526) Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2)| (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK) Length = 625 Score = 56.2 bits (134), Expect = 4e-08 Identities = 38/103 (36%), Positives = 57/103 (55%), Gaps = 1/103 (0%) Frame = +3 Query: 132 IIKNEDLEELRELGSGTFGTVYHGKWRGTD-VAIKRIKKSCFTGRSSEQERLAQEFWREA 308 +I+ +L ++E+GSG FG V+ G W D VAIK I++ G SE++ F EA Sbjct: 362 VIQPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIQE----GAMSEED-----FIEEA 412 Query: 309 EILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQ 437 E++ KL HP +V YGV + + + EFM +G L L+ Sbjct: 413 EVMMKLSHPKLVQLYGVCLE--QAPICLVFEFMEHGCLSDYLR 453
>SRC_CHICK (P00523) Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2)| (p60-Src) (c-Src) (pp60c-src) Length = 532 Score = 56.2 bits (134), Expect = 4e-08 Identities = 41/118 (34%), Positives = 59/118 (50%), Gaps = 2/118 (1%) Frame = +3 Query: 135 IKNEDLEELRELGSGTFGTVYHGKWRGTD-VAIKRIKKSCFTGRSSEQERLAQEFWREAE 311 I E L +LG G FG V+ G W GT VAIK +K + + F +EA+ Sbjct: 261 IPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMS---------PEAFLQEAQ 311 Query: 312 ILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQ-RKGQCPDLPQRLIIA 482 ++ KL H +V Y VV + P + +TE+M GSL L+ G+ LPQ + +A Sbjct: 312 VMKKLRHEKLVQLYAVVSEEP---IYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMA 366
>SRC_RSVSA (P00524) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 56.2 bits (134), Expect = 4e-08 Identities = 41/118 (34%), Positives = 59/118 (50%), Gaps = 2/118 (1%) Frame = +3 Query: 135 IKNEDLEELRELGSGTFGTVYHGKWRGTD-VAIKRIKKSCFTGRSSEQERLAQEFWREAE 311 I E L +LG G FG V+ G W GT VAIK +K + + F +EA+ Sbjct: 261 IPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMS---------PEAFLQEAQ 311 Query: 312 ILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQ-RKGQCPDLPQRLIIA 482 ++ KL H +V Y VV + P + +TE+M GSL L+ G+ LPQ + +A Sbjct: 312 VMKKLRHEKLVQLYAVVSEEP---IYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMA 366
>SRC_AVISR (P00525) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 56.2 bits (134), Expect = 4e-08 Identities = 41/118 (34%), Positives = 59/118 (50%), Gaps = 2/118 (1%) Frame = +3 Query: 135 IKNEDLEELRELGSGTFGTVYHGKWRGTD-VAIKRIKKSCFTGRSSEQERLAQEFWREAE 311 I E L +LG G FG V+ G W GT VAIK +K + + F +EA+ Sbjct: 261 IPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMS---------PEAFLQEAQ 311 Query: 312 ILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQ-RKGQCPDLPQRLIIA 482 ++ KL H +V Y VV + P + +TE+M GSL L+ G+ LPQ + +A Sbjct: 312 VMKKLRHEKLVQLYAVVSEEP---IYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMA 366
>SRC_AVIS2 (P15054) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 586 Score = 56.2 bits (134), Expect = 4e-08 Identities = 41/118 (34%), Positives = 59/118 (50%), Gaps = 2/118 (1%) Frame = +3 Query: 135 IKNEDLEELRELGSGTFGTVYHGKWRGTD-VAIKRIKKSCFTGRSSEQERLAQEFWREAE 311 I E L +LG G FG V+ G W GT VAIK +K + + F +EA+ Sbjct: 261 IPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMS---------PEAFLQEAQ 311 Query: 312 ILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQ-RKGQCPDLPQRLIIA 482 ++ KL H +V Y VV + P + +TE+M GSL L+ G+ LPQ + +A Sbjct: 312 VMKKLRHEKLVQLYAVVSEEP---IYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMA 366
>ITK_HUMAN (Q08881) Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2)| (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT) Length = 620 Score = 55.8 bits (133), Expect = 6e-08 Identities = 38/103 (36%), Positives = 56/103 (54%), Gaps = 1/103 (0%) Frame = +3 Query: 132 IIKNEDLEELRELGSGTFGTVYHGKWRGTD-VAIKRIKKSCFTGRSSEQERLAQEFWREA 308 +I +L ++E+GSG FG V+ G W D VAIK I++ G SE++ F EA Sbjct: 357 VIDPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIRE----GAMSEED-----FIEEA 407 Query: 309 EILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQ 437 E++ KL HP +V YGV + + + EFM +G L L+ Sbjct: 408 EVMMKLSHPKLVQLYGVCLE--QAPICLVFEFMEHGCLSDYLR 448
>SRC_RAT (Q9WUD9) Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2)| (p60-Src) (c-Src) (pp60c-src) Length = 535 Score = 55.5 bits (132), Expect = 7e-08 Identities = 40/113 (35%), Positives = 56/113 (49%), Gaps = 2/113 (1%) Frame = +3 Query: 135 IKNEDLEELRELGSGTFGTVYHGKWRGTD-VAIKRIKKSCFTGRSSEQERLAQEFWREAE 311 I E L +LG G FG V+ G W GT VAIK +K + + F +EA+ Sbjct: 264 IPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMS---------PEAFLQEAQ 314 Query: 312 ILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQ-RKGQCPDLPQ 467 ++ KL H +V Y VV + P + +TE+M GSL L+ G+ LPQ Sbjct: 315 VMKKLRHEKLVQLYAVVSEEP---IYIVTEYMNKGSLLDFLKGETGKYLRLPQ 364
>SRC2_XENLA (P13116) Tyrosine-protein kinase Src-2 (EC 2.7.10.2) (p60-Src-2)| Length = 531 Score = 55.5 bits (132), Expect = 7e-08 Identities = 40/118 (33%), Positives = 59/118 (50%), Gaps = 2/118 (1%) Frame = +3 Query: 135 IKNEDLEELRELGSGTFGTVYHGKWRGTD-VAIKRIKKSCFTGRSSEQERLAQEFWREAE 311 I + L +LG G FG V+ G W GT VAIK +K + + F +EA+ Sbjct: 260 IPRDSLRLELKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMS---------PEAFLQEAQ 310 Query: 312 ILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQ-RKGQCPDLPQRLIIA 482 ++ KL H +V Y VV + P + +TE+M GSL L+ G+ LPQ + +A Sbjct: 311 VMKKLRHEKLVQLYAVVSEEP---IYIVTEYMSKGSLLDFLKGEMGRYLRLPQLVDMA 365
>JAK1_CYPCA (Q09178) Tyrosine-protein kinase Jak1 (EC 2.7.10.2) (Janus kinase 1)| (Jak-1) Length = 1156 Score = 55.5 bits (132), Expect = 7e-08 Identities = 35/116 (30%), Positives = 56/116 (48%), Gaps = 6/116 (5%) Frame = +3 Query: 132 IIKNEDLEELRELGSGTFGTVY------HGKWRGTDVAIKRIKKSCFTGRSSEQERLAQE 293 + + L+++R+LG G FG V G G VA+K +K +E + Sbjct: 869 VFEKRFLKKIRDLGEGHFGKVELCRYDPRGDRTGELVAVKSLKPE-------NREEQSSN 921 Query: 294 FWREAEILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQRKGQCPDL 461 WRE IL +L+H N+V + G+ + G ++ + EF+ GSL+ L R DL Sbjct: 922 LWREIHILRELYHENIVKYKGIWHEEGGRSIKLIMEFLPAGSLKEYLPRNKAHIDL 977
>SRC_MOUSE (P05480) Neuronal proto-oncogene tyrosine-protein kinase Src (EC| 2.7.10.2) (p60-Src) (c-Src) (pp60c-src) Length = 540 Score = 55.5 bits (132), Expect = 7e-08 Identities = 40/113 (35%), Positives = 56/113 (49%), Gaps = 2/113 (1%) Frame = +3 Query: 135 IKNEDLEELRELGSGTFGTVYHGKWRGTD-VAIKRIKKSCFTGRSSEQERLAQEFWREAE 311 I E L +LG G FG V+ G W GT VAIK +K + + F +EA+ Sbjct: 269 IPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMS---------PEAFLQEAQ 319 Query: 312 ILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQ-RKGQCPDLPQ 467 ++ KL H +V Y VV + P + +TE+M GSL L+ G+ LPQ Sbjct: 320 VMKKLRHEKLVQLYAVVSEEP---IYIVTEYMNKGSLLDFLKGETGKYLRLPQ 369
>TRK1_LYMST (O76997) Putative neurotrophin receptor LTRK 1 precursor (EC| 2.7.10.1) Length = 794 Score = 55.1 bits (131), Expect = 1e-07 Identities = 36/103 (34%), Positives = 52/103 (50%), Gaps = 7/103 (6%) Frame = +3 Query: 159 LRELGSGTFGTVYHG-------KWRGTDVAIKRIKKSCFTGRSSEQERLAQEFWREAEIL 317 +R +G G FG V+ G K VA+K +K SC + L ++F REAE+L Sbjct: 507 MRVIGEGAFGRVFLGTCAHLIQKNEFAIVAVKTLKGSC-------SDSLKRDFEREAEML 559 Query: 318 SKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQRKG 446 + + H N+V FYGV + + + EFM NG L L+ G Sbjct: 560 ATIEHANIVTFYGVCTESDQWMM--IFEFMENGDLNKYLRMHG 600
>EPHB5_CHICK (Q07497) Ephrin type-B receptor 5 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase CEK9) Length = 1002 Score = 55.1 bits (131), Expect = 1e-07 Identities = 42/107 (39%), Positives = 56/107 (52%), Gaps = 1/107 (0%) Frame = +3 Query: 126 LQIIKNEDLEELRELGSGTFGTVYHGKWRGTDVAIKRIKKSCFTGRSSEQERLAQEFWRE 305 + IK E++ E G FG + H R VAIK +K +G + EQ R EF E Sbjct: 634 VSFIKIEEVIGSGEFGEVCFGRLKHPGKREYTVAIKTLK----SGYTDEQRR---EFLSE 686 Query: 306 AEILSKLHHPNVVAFYGVV-KDGPGGTLATLTEFMVNGSLRHVLQRK 443 A I+ + HPNV+ GVV K P + +TEFM NGSL L++K Sbjct: 687 ASIMGQFEHPNVIHLEGVVTKSRP---VMIVTEFMENGSLDSFLRQK 730
>SRK3_SPOLA (P42689) Tyrosine-protein kinase SRK3 (EC 2.7.10.2) (Fragment)| Length = 334 Score = 55.1 bits (131), Expect = 1e-07 Identities = 32/93 (34%), Positives = 49/93 (52%), Gaps = 1/93 (1%) Frame = +3 Query: 162 RELGSGTFGTVYHGKWRGTD-VAIKRIKKSCFTGRSSEQERLAQEFWREAEILSKLHHPN 338 R+LG G FG V+ G W GT VA+K +K ++F +EA+++ K+HHPN Sbjct: 70 RKLGQGNFGEVWAGVWNGTTAVAVKTLKPDTME---------VKDFVQEAQVMKKIHHPN 120 Query: 339 VVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQ 437 ++ Y V G + +TE M GS+ L+ Sbjct: 121 LLQLYAVCTIGE--PIYIVTELMKYGSMLEYLK 151
>HT1_ARATH (Q2MHE4) Serine/threonine-protein kinase HT1 (EC 2.7.11.1) (High| leaf temperature protein 1) Length = 390 Score = 54.7 bits (130), Expect = 1e-07 Identities = 33/102 (32%), Positives = 52/102 (50%), Gaps = 3/102 (2%) Frame = +3 Query: 147 DLEEL---RELGSGTFGTVYHGKWRGTDVAIKRIKKSCFTGRSSEQERLAQEFWREAEIL 317 DL +L + SG +Y G ++ VA+K ++ T + + +L Q+F E +L Sbjct: 82 DLSQLFIGNKFASGAHSRIYRGIYKQRAVAVKMVRIP--THKEETRAKLEQQFKSEVALL 139 Query: 318 SKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQRK 443 S+L HPN+V F K P +TE+M G+LR L +K Sbjct: 140 SRLFHPNIVQFIAACKKPP--VYCIITEYMSQGNLRMYLNKK 179
>SRC_RSVH1 (P25020) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 54.7 bits (130), Expect = 1e-07 Identities = 40/118 (33%), Positives = 58/118 (49%), Gaps = 2/118 (1%) Frame = +3 Query: 135 IKNEDLEELRELGSGTFGTVYHGKWRGTD-VAIKRIKKSCFTGRSSEQERLAQEFWREAE 311 I E L +LG G FG V+ G W GT VAIK +K + + F +EA+ Sbjct: 261 IPRESLRLEAKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMS---------PEAFLQEAQ 311 Query: 312 ILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQ-RKGQCPDLPQRLIIA 482 ++ KL H +V Y VV + P + + E+M GSL L+ G+ LPQ + +A Sbjct: 312 VMKKLRHEKLVQLYAVVSEEP---IYIVIEYMSKGSLLDFLKGEMGKYLRLPQLVDMA 366
>FRK_HUMAN (P42685) Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear| tyrosine protein kinase RAK) Length = 505 Score = 54.3 bits (129), Expect = 2e-07 Identities = 35/103 (33%), Positives = 51/103 (49%), Gaps = 2/103 (1%) Frame = +3 Query: 135 IKNEDLEELRELGSGTFGTVYHGKWRG-TDVAIKRIKKSCFTGRSSEQERLAQEFWREAE 311 I ++ L+ LGSG FG V+ G W T VA+K +K +F REA+ Sbjct: 229 IDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMD---------PNDFLREAQ 279 Query: 312 ILSKLHHPNVVAFYGV-VKDGPGGTLATLTEFMVNGSLRHVLQ 437 I+ L HP ++ Y V + P + +TE M +GSL+ LQ Sbjct: 280 IMKNLRHPKLIQLYAVCTLEDP---IYIITELMRHGSLQEYLQ 319
>NTRK1_RAT (P35739) High affinity nerve growth factor receptor precursor (EC| 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (p140-TrkA) (Slow nerve growth factor receptor) (Trk-A) Length = 799 Score = 54.3 bits (129), Expect = 2e-07 Identities = 38/111 (34%), Positives = 57/111 (51%), Gaps = 7/111 (6%) Frame = +3 Query: 135 IKNEDLEELRELGSGTFGTVY----HGKWRGTD---VAIKRIKKSCFTGRSSEQERLAQE 293 IK +D+ ELG G FG V+ + D VA+K +K++ E Q+ Sbjct: 508 IKRQDIILKWELGEGAFGKVFLAECYNLLNDQDKMLVAVKALKET--------SENARQD 559 Query: 294 FWREAEILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQRKG 446 F REAE+L+ L H ++V F+GV + GG L + E+M +G L L+ G Sbjct: 560 FHREAELLTMLQHQHIVRFFGVCTE--GGPLLMVFEYMRHGDLNRFLRSHG 608
>M3K13_PONPY (Q5R8X7) Mitogen-activated protein kinase kinase kinase 13 (EC| 2.7.11.25) Length = 966 Score = 54.3 bits (129), Expect = 2e-07 Identities = 33/98 (33%), Positives = 51/98 (52%) Frame = +3 Query: 144 EDLEELRELGSGTFGTVYHGKWRGTDVAIKRIKKSCFTGRSSEQERLAQEFWREAEILSK 323 E++ EL+ LGSG G V+ GK+R +VAIK++++ T + + L K Sbjct: 166 EEISELQWLGSGAQGAVFLGKFRAEEVAIKKVREQNET---------------DIKHLRK 210 Query: 324 LHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQ 437 L HPN++AF GV P + E+ +G L VL+ Sbjct: 211 LKHPNIIAFKGVCTQAP--CYCIIMEYCAHGQLYEVLR 246
>M3K13_HUMAN (O43283) Mitogen-activated protein kinase kinase kinase 13 (EC| 2.7.11.25) (Mixed lineage kinase) (MLK) (Leucine zipper-bearing kinase) Length = 966 Score = 54.3 bits (129), Expect = 2e-07 Identities = 33/98 (33%), Positives = 51/98 (52%) Frame = +3 Query: 144 EDLEELRELGSGTFGTVYHGKWRGTDVAIKRIKKSCFTGRSSEQERLAQEFWREAEILSK 323 E++ EL+ LGSG G V+ GK+R +VAIK++++ T + + L K Sbjct: 166 EEISELQWLGSGAQGAVFLGKFRAEEVAIKKVREQNET---------------DIKHLRK 210 Query: 324 LHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQ 437 L HPN++AF GV P + E+ +G L VL+ Sbjct: 211 LKHPNIIAFKGVCTQAP--CYCIIMEYCAHGQLYEVLR 246
>M3K1_ARATH (O22040) Mitogen-activated protein kinase kinase kinase 1 (EC| 2.7.11.25) (Arabidospsis NPK1-related protein kinase 1) Length = 666 Score = 53.9 bits (128), Expect = 2e-07 Identities = 32/99 (32%), Positives = 52/99 (52%), Gaps = 2/99 (2%) Frame = +3 Query: 168 LGSGTFGTVYHGKW--RGTDVAIKRIKKSCFTGRSSEQERLAQEFWREAEILSKLHHPNV 341 +G G FGTVY G G +A+K++ + + + QE E ++L L HPN+ Sbjct: 75 IGRGAFGTVYMGMNLDSGELLAVKQVLIAANFASKEKTQAHIQELEEEVKLLKNLSHPNI 134 Query: 342 VAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQRKGQCPD 458 V + G V++ TL L EF+ GS+ +L++ G P+ Sbjct: 135 VRYLGTVRE--DDTLNILLEFVPGGSISSLLEKFGPFPE 171
>SRC1_XENLA (P13115) Tyrosine-protein kinase Src-1 (EC 2.7.10.2) (p60-Src-1)| Length = 531 Score = 53.9 bits (128), Expect = 2e-07 Identities = 39/118 (33%), Positives = 59/118 (50%), Gaps = 2/118 (1%) Frame = +3 Query: 135 IKNEDLEELRELGSGTFGTVYHGKWRGTD-VAIKRIKKSCFTGRSSEQERLAQEFWREAE 311 I + L +LG G FG V+ G W GT VAIK +K + + F +EA+ Sbjct: 260 IPRDSLRLELKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMS---------PEAFLQEAQ 310 Query: 312 ILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQ-RKGQCPDLPQRLIIA 482 ++ KL H +V Y VV + P + +TE++ GSL L+ G+ LPQ + +A Sbjct: 311 VMKKLRHEKLVQLYAVVSEEP---IYIVTEYISKGSLLDFLKGEMGRYLRLPQLVDMA 365
>FGR_MOUSE (P14234) Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2)| (P55-FGR) (C-FGR) Length = 517 Score = 53.9 bits (128), Expect = 2e-07 Identities = 39/109 (35%), Positives = 56/109 (51%), Gaps = 2/109 (1%) Frame = +3 Query: 162 RELGSGTFGTVYHGKWR-GTDVAIKRIKKSCFTGRSSEQERLAQEFWREAEILSKLHHPN 338 R LG+G FG V+ G W T VA+K +K + ++ F EA+I+ L H Sbjct: 255 RRLGTGCFGDVWLGTWNCSTKVAVKTLKPGTMSPKA---------FLEEAQIMKLLRHDK 305 Query: 339 VVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQ-RKGQCPDLPQRLIIA 482 +V Y VV + P + +TEFM GSL L+ R+GQ LP + +A Sbjct: 306 LVQLYAVVSEEP---IYIVTEFMCYGSLLDFLKDREGQNLMLPHLVDMA 351
>SRC64_DROME (P00528) Tyrosine-protein kinase Src64B (EC 2.7.10.2) (Dsrc64)| Length = 552 Score = 53.9 bits (128), Expect = 2e-07 Identities = 33/102 (32%), Positives = 52/102 (50%), Gaps = 1/102 (0%) Frame = +3 Query: 135 IKNEDLEELRELGSGTFGTVYHGKWRGT-DVAIKRIKKSCFTGRSSEQERLAQEFWREAE 311 I +++ LR+LG G FG V++GKWR + DVA+K +++ + F +EA Sbjct: 279 IPRSEIQLLRKLGRGNFGEVFYGKWRNSIDVAVKTLREGTMS---------TAAFLQEAA 329 Query: 312 ILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQ 437 I+ K H +VA Y V + + E+M GSL L+ Sbjct: 330 IMKKFRHNRLVALYAVCSQEE--PIYIVQEYMSKGSLLDFLR 369
>M3K2_ARATH (Q9FZ36) Mitogen-activated protein kinase kinase kinase 2 (EC| 2.7.11.25) (Arabidospsis NPK1-related protein kinase 2) Length = 651 Score = 53.9 bits (128), Expect = 2e-07 Identities = 32/99 (32%), Positives = 52/99 (52%), Gaps = 2/99 (2%) Frame = +3 Query: 168 LGSGTFGTVYHGKW--RGTDVAIKRIKKSCFTGRSSEQERLAQEFWREAEILSKLHHPNV 341 +G G FGTVY G G +A+K++ + + + QE E ++L L HPN+ Sbjct: 74 IGRGAFGTVYMGMNLDSGELLAVKQVLITSNCASKEKTQAHIQELEEEVKLLKNLSHPNI 133 Query: 342 VAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQRKGQCPD 458 V + G V++ TL L EF+ GS+ +L++ G P+ Sbjct: 134 VRYLGTVREDE--TLNILLEFVPGGSISSLLEKFGAFPE 170
>SRC_RSVSE (P63185) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 53.9 bits (128), Expect = 2e-07 Identities = 40/118 (33%), Positives = 58/118 (49%), Gaps = 2/118 (1%) Frame = +3 Query: 135 IKNEDLEELRELGSGTFGTVYHGKWRGTD-VAIKRIKKSCFTGRSSEQERLAQEFWREAE 311 I E L +LG G FG V+ G W GT VAIK +K + + F +EA+ Sbjct: 261 IPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMS---------PEAFLQEAQ 311 Query: 312 ILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQ-RKGQCPDLPQRLIIA 482 ++ KL H +V Y VV + P + + E+M GSL L+ G+ LPQ + +A Sbjct: 312 VMKKLRHKKLVQLYAVVSEEP---IYIVIEYMSKGSLLDFLKGEMGKYLRLPQLVDMA 366
>ROR1_DROME (Q24488) Tyrosine-protein kinase transmembrane receptor Ror| precursor (EC 2.7.10.1) (dRor) Length = 685 Score = 53.9 bits (128), Expect = 2e-07 Identities = 37/102 (36%), Positives = 51/102 (50%), Gaps = 5/102 (4%) Frame = +3 Query: 144 EDLEELRELGSGTFGTVYHGKWRGTD-----VAIKRIKKSCFTGRSSEQERLAQEFWREA 308 +D+E L ELG G FG VY G+ + VAIK +K++ + Q+F RE Sbjct: 408 QDVEFLEELGEGAFGKVYKGQLLQPNKTTITVAIKALKENASV-------KTQQDFKREI 460 Query: 309 EILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVL 434 E++S L H N+V GVV + L E+M NG L L Sbjct: 461 ELISDLKHQNIVCILGVVLNKE--PYCMLFEYMANGDLHEFL 500
>CRI4_MAIZE (O24585) Putative receptor protein kinase CRINKLY4 precursor (EC| 2.7.11.1) Length = 901 Score = 53.1 bits (126), Expect = 4e-07 Identities = 42/132 (31%), Positives = 69/132 (52%), Gaps = 8/132 (6%) Frame = +3 Query: 102 LRDSDFEHLQIIKNEDLEELR-------ELGSGTFGTVYHGKWR-GTDVAIKRIKKSCFT 257 + D Q E+LE+ ++G G+F V+ G R GT VA+KR K+ Sbjct: 482 MEDLKIRRAQEFSYEELEQATGGFSEDSQVGKGSFSCVFKGILRDGTVVAVKRAIKA--- 538 Query: 258 GRSSEQERLAQEFWREAEILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQ 437 S+ ++ ++EF E ++LS+L+H +++ G +DG L + EFM +GSL L Sbjct: 539 ---SDVKKSSKEFHNELDLLSRLNHAHLLNLLGYCEDGSERLL--VYEFMAHGSLYQHLH 593 Query: 438 RKGQCPDLPQRL 473 G+ P+L +RL Sbjct: 594 --GKDPNLKKRL 603
>MOS_RAT (P00539) Proto-oncogene serine/threonine-protein kinase mos (EC| 2.7.11.1) (c-mos) (Oocyte maturation factor mos) Length = 339 Score = 52.8 bits (125), Expect = 5e-07 Identities = 36/103 (34%), Positives = 53/103 (51%), Gaps = 3/103 (2%) Frame = +3 Query: 159 LRELGSGTFGTVYHGKWRGTDVAIKRIKKSCFTGRSSEQERLAQEFWREAEILSKLHHPN 338 L LGSG FG+VY + G VAIK++ K T R+S+ + FW E I ++LHH N Sbjct: 64 LHRLGSGGFGSVYKATYHGVPVAIKQVNKCTRTLRASQ-----RNFWAELNI-ARLHHDN 117 Query: 339 VVAFYGVVKDGPGG--TLAT-LTEFMVNGSLRHVLQRKGQCPD 458 ++ P G +L T + EF N +L V+ + P+ Sbjct: 118 IIRVVAASTRTPEGSNSLGTIIMEFGGNVTLHQVIYGATRSPE 160
>M3K9_HUMAN (P80192) Mitogen-activated protein kinase kinase kinase 9 (EC| 2.7.11.25) (Mixed lineage kinase 1) Length = 1104 Score = 52.8 bits (125), Expect = 5e-07 Identities = 37/104 (35%), Positives = 50/104 (48%) Frame = +3 Query: 150 LEELRELGSGTFGTVYHGKWRGTDVAIKRIKKSCFTGRSSEQERLAQEFWREAEILSKLH 329 LEE+ +G G FG VY W G +VA+K + S E + Q EA++ + L Sbjct: 146 LEEI--IGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQ----EAKLFAMLK 199 Query: 330 HPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQRKGQCPDL 461 HPN++A GV P L + EF G L VL K PD+ Sbjct: 200 HPNIIALRGVCLKEP--NLCLVMEFARGGPLNRVLSGKRIPPDI 241
>FAK2_RAT (P70600) Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal| adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) Length = 1009 Score = 52.8 bits (125), Expect = 5e-07 Identities = 40/139 (28%), Positives = 63/139 (45%), Gaps = 5/139 (3%) Frame = +3 Query: 81 AQVMDASLRDSDFEHLQIIKNEDLEELRELGSGTFGTVYHG-----KWRGTDVAIKRIKK 245 A++ D +LR + + ED+ R LG G FG VY G K +VA+K KK Sbjct: 403 AEIPDETLRRPGGPQYGVAR-EDVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKK 461 Query: 246 SCFTGRSSEQERLAQEFWREAEILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLR 425 C ++F EA I+ L HP++V G++++ P + L + G L Sbjct: 462 DCTLDNK-------EKFMSEAVIMKNLDHPHIVKLIGIIEEEPTWIVMELYPY---GELG 511 Query: 426 HVLQRKGQCPDLPQRLIIA 482 H L+R +P ++ A Sbjct: 512 HYLERNKNSLKVPTLVLYA 530
>FYN_MOUSE (P39688) Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2)| (p59-Fyn) Length = 533 Score = 52.8 bits (125), Expect = 5e-07 Identities = 38/109 (34%), Positives = 55/109 (50%), Gaps = 2/109 (1%) Frame = +3 Query: 162 RELGSGTFGTVYHGKWRG-TDVAIKRIKKSCFTGRSSEQERLAQEFWREAEILSKLHHPN 338 ++LG G F V+ G W G T VAIK +K + S F EA+I+ KL H Sbjct: 271 KKLGQGCFAEVWLGTWNGNTKVAIKTLKPGTMSPES---------FLEEAQIMKKLKHDK 321 Query: 339 VVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQ-RKGQCPDLPQRLIIA 482 +V Y VV + P + +TE+M GSL L+ +G+ LP + +A Sbjct: 322 LVQLYAVVSEEP---IYIVTEYMSKGSLLDFLKDGEGRALKLPNLVDMA 367
>ABL1_CAEEL (P03949) Tyrosine-protein kinase abl-1 (EC 2.7.10.2)| Length = 1224 Score = 52.8 bits (125), Expect = 5e-07 Identities = 35/95 (36%), Positives = 47/95 (49%), Gaps = 3/95 (3%) Frame = +3 Query: 165 ELGSGTFGTVYHGKWRGTD--VAIKRIKKSCFTGRSSEQERLAQEFWREAEILSKLHHPN 338 +LG G +G VY G W+ D +A+K +K E EF EA I+ LHH N Sbjct: 316 KLGGGQYGDVYEGYWKRHDCTIAVKALK---------EDAMPLHEFLAEAAIMKDLHHKN 366 Query: 339 VVAFYGV-VKDGPGGTLATLTEFMVNGSLRHVLQR 440 +V GV + P +TEFM NG+L L+R Sbjct: 367 LVRLLGVCTHEAP---FYIITEFMCNGNLLEYLRR 398
>BRAF1_CHICK (Q04982) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Rmil serine/threonine-protein kinase) (c-Rmil) Length = 806 Score = 52.4 bits (124), Expect = 6e-07 Identities = 40/134 (29%), Positives = 60/134 (44%) Frame = +3 Query: 33 PAPDFEEPKFEEDRTAAQVMDASLRDSDFEHLQIIKNEDLEELRELGSGTFGTVYHGKWR 212 P + + EDR + + D+E I + + + +GSG+FGTVY GKW Sbjct: 462 PQRERKSSSSSEDRNRMKTLGRRDSSDDWE----IPDGQITVGQRIGSGSFGTVYKGKWH 517 Query: 213 GTDVAIKRIKKSCFTGRSSEQERLAQEFWREAEILSKLHHPNVVAFYGVVKDGPGGTLAT 392 G DVA+K + + T + Q F E +L K H N++ F G LA Sbjct: 518 G-DVAVKMLNVTAPTPQQ------LQAFKNEVGVLRKTRHVNILLFMGY---STKPQLAI 567 Query: 393 LTEFMVNGSLRHVL 434 +T++ SL H L Sbjct: 568 VTQWCEGSSLYHHL 581
>RMIL_AVEVR (P27966) Serine/threonine-protein kinase transforming protein Rmil| (EC 2.7.11.1) Length = 450 Score = 52.4 bits (124), Expect = 6e-07 Identities = 40/134 (29%), Positives = 60/134 (44%) Frame = +3 Query: 33 PAPDFEEPKFEEDRTAAQVMDASLRDSDFEHLQIIKNEDLEELRELGSGTFGTVYHGKWR 212 P + + EDR + + D+E I + + + +GSG+FGTVY GKW Sbjct: 48 PQRERKSSSSSEDRNRMKTLGRRDSSDDWE----IPDGQITVGQRIGSGSFGTVYKGKWH 103 Query: 213 GTDVAIKRIKKSCFTGRSSEQERLAQEFWREAEILSKLHHPNVVAFYGVVKDGPGGTLAT 392 G DVA+K + + T + Q F E +L K H N++ F G LA Sbjct: 104 G-DVAVKMLNVTAPTPQQ------LQAFKNEVGVLRKTRHVNILLFMGY---STKPQLAI 153 Query: 393 LTEFMVNGSLRHVL 434 +T++ SL H L Sbjct: 154 VTQWCEGSSLYHHL 167
>MOS_VULGR (Q90XV7) Serine/threonine-protein kinase mos (EC 2.7.11.1) (Oocyte| maturation factor mos) (Fragment) Length = 200 Score = 52.4 bits (124), Expect = 6e-07 Identities = 37/101 (36%), Positives = 53/101 (52%), Gaps = 5/101 (4%) Frame = +3 Query: 159 LRELGSGTFGTVYHGKWRGTDVAIKRIKKSCFTGRSSEQERLA--QEFWREAEILSKLHH 332 L+ LGSG FG+VY + G VA+K++KK S + RLA Q FW E + ++L H Sbjct: 5 LQPLGSGGFGSVYKATYHGATVAVKQVKK-------SSKNRLASRQSFWAELNV-ARLQH 56 Query: 333 PNVVAFYGVVKDGPG--GTLAT-LTEFMVNGSLRHVLQRKG 446 NVV P +L T + E++ N +L HV+ G Sbjct: 57 NNVVRVVAASTCAPASQNSLGTIIMEYVGNITLHHVIYGTG 97
>MOS_GYMCA (Q90XV6) Serine/threonine-protein kinase mos (EC 2.7.11.1) (Oocyte| maturation factor mos) (Fragment) Length = 200 Score = 52.4 bits (124), Expect = 6e-07 Identities = 37/101 (36%), Positives = 53/101 (52%), Gaps = 5/101 (4%) Frame = +3 Query: 159 LRELGSGTFGTVYHGKWRGTDVAIKRIKKSCFTGRSSEQERLA--QEFWREAEILSKLHH 332 L+ LGSG FG+VY + G VA+K++KK S + RLA Q FW E + ++L H Sbjct: 5 LQPLGSGGFGSVYKATYHGATVAVKQVKK-------SSKNRLASRQSFWAELNV-ARLQH 56 Query: 333 PNVVAFYGVVKDGPG--GTLAT-LTEFMVNGSLRHVLQRKG 446 NVV P +L T + E++ N +L HV+ G Sbjct: 57 NNVVRVVAASTCAPASQNSLGTIIMEYVGNITLHHVIYGTG 97
>BRAF1_HUMAN (P15056) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (p94) (v-Raf murine sarcoma viral oncogene homolog B1) Length = 766 Score = 52.4 bits (124), Expect = 6e-07 Identities = 40/134 (29%), Positives = 60/134 (44%) Frame = +3 Query: 33 PAPDFEEPKFEEDRTAAQVMDASLRDSDFEHLQIIKNEDLEELRELGSGTFGTVYHGKWR 212 P + + EDR + + D+E I + + + +GSG+FGTVY GKW Sbjct: 422 PQRERKSSSSSEDRNRMKTLGRRDSSDDWE----IPDGQITVGQRIGSGSFGTVYKGKWH 477 Query: 213 GTDVAIKRIKKSCFTGRSSEQERLAQEFWREAEILSKLHHPNVVAFYGVVKDGPGGTLAT 392 G DVA+K + + T + Q F E +L K H N++ F G LA Sbjct: 478 G-DVAVKMLNVTAPTPQQ------LQAFKNEVGVLRKTRHVNILLFMGY---STKPQLAI 527 Query: 393 LTEFMVNGSLRHVL 434 +T++ SL H L Sbjct: 528 VTQWCEGSSLYHHL 541
>WNK4_RAT (Q7TPK6) Serine/threonine-protein kinase WNK4 (EC 2.7.11.1)| (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4) Length = 1222 Score = 52.4 bits (124), Expect = 6e-07 Identities = 44/139 (31%), Positives = 61/139 (43%), Gaps = 5/139 (3%) Frame = +3 Query: 39 PDFEEPKFEEDRTAAQVMDASLRDSDFEHLQIIKNEDLEELR---ELGSGTFGTVYHGKW 209 P EP D A + D E + + D L+ E+G G+F TVY G Sbjct: 131 PGSREPPRVPDAAARERRREQEEKEDTETQAVATSPDGRYLKFDIEIGRGSFKTVYRGL- 189 Query: 210 RGTDVAIKRIKKSCFTGRSSEQERLAQEFWREAEILSKLHHPNVVAFYGVVKDGPGG--T 383 TD ++ T + S ER Q F E E+L L HPN+V FY K G Sbjct: 190 -DTDTTVEVAWCELQTRKLSRAER--QRFSEEVEMLKGLQHPNIVRFYDSWKSVLRGQVC 246 Query: 384 LATLTEFMVNGSLRHVLQR 440 + +TE M +G+L+ L+R Sbjct: 247 IVLVTELMTSGTLKTYLRR 265
>WNK4_MOUSE (Q80UE6) Serine/threonine-protein kinase WNK4 (EC 2.7.11.1)| (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4) Length = 1222 Score = 52.4 bits (124), Expect = 6e-07 Identities = 44/139 (31%), Positives = 61/139 (43%), Gaps = 5/139 (3%) Frame = +3 Query: 39 PDFEEPKFEEDRTAAQVMDASLRDSDFEHLQIIKNEDLEELR---ELGSGTFGTVYHGKW 209 P EP D A + D E + + D L+ E+G G+F TVY G Sbjct: 131 PGSREPPRVPDAAARERRREQEEKEDTETQAVATSPDGRYLKFDIEIGRGSFKTVYRGL- 189 Query: 210 RGTDVAIKRIKKSCFTGRSSEQERLAQEFWREAEILSKLHHPNVVAFYGVVKDGPGG--T 383 TD ++ T + S ER Q F E E+L L HPN+V FY K G Sbjct: 190 -DTDTTVEVAWCELQTRKLSRAER--QRFSEEVEMLKGLQHPNIVRFYDSWKSVLRGQVC 246 Query: 384 LATLTEFMVNGSLRHVLQR 440 + +TE M +G+L+ L+R Sbjct: 247 IVLVTELMTSGTLKTYLRR 265
>SRC_RSVPA (P31693) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 522 Score = 52.4 bits (124), Expect = 6e-07 Identities = 39/118 (33%), Positives = 58/118 (49%), Gaps = 2/118 (1%) Frame = +3 Query: 135 IKNEDLEELRELGSGTFGTVYHGKWRGTD-VAIKRIKKSCFTGRSSEQERLAQEFWREAE 311 I E L +LG G FG V+ G W GT VAIK +K + + F +EA+ Sbjct: 258 IPRESLRLEVKLGQGYFGEVWMGTWNGTTRVAIKTLKPGTMS---------PEAFLQEAQ 308 Query: 312 ILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQ-RKGQCPDLPQRLIIA 482 ++ KL H +V Y +V + P + + E+M GSL L+ G+ LPQ + +A Sbjct: 309 VMKKLRHEKLVQLYAMVSEEP---IYIVIEYMSKGSLLDFLKGEMGKYLRLPQLVEMA 363
>RMIL_AVII1 (P10533) Serine/threonine-protein kinase transforming protein Rmil| (EC 2.7.11.1) Length = 367 Score = 52.4 bits (124), Expect = 6e-07 Identities = 40/134 (29%), Positives = 60/134 (44%) Frame = +3 Query: 33 PAPDFEEPKFEEDRTAAQVMDASLRDSDFEHLQIIKNEDLEELRELGSGTFGTVYHGKWR 212 P + + EDR + + D+E I + + + +GSG+FGTVY GKW Sbjct: 32 PQRERKSSSSSEDRNRMKTLGRRDSSDDWE----IPDGQITVGQRIGSGSFGTVYKGKWH 87 Query: 213 GTDVAIKRIKKSCFTGRSSEQERLAQEFWREAEILSKLHHPNVVAFYGVVKDGPGGTLAT 392 G DVA+K + + T + Q F E +L K H N++ F G LA Sbjct: 88 G-DVAVKMLNVTAPTPQQ------LQAFKNEVGVLRKTRHVNILLFMGY---STKPQLAI 137 Query: 393 LTEFMVNGSLRHVL 434 +T++ SL H L Sbjct: 138 VTQWCEGSSLYHHL 151
>BRAF1_COTJA (P34908) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (RMIL serine/threonine-protein kinase) (c-RMIL) Length = 807 Score = 52.4 bits (124), Expect = 6e-07 Identities = 40/134 (29%), Positives = 60/134 (44%) Frame = +3 Query: 33 PAPDFEEPKFEEDRTAAQVMDASLRDSDFEHLQIIKNEDLEELRELGSGTFGTVYHGKWR 212 P + + EDR + + D+E I + + + +GSG+FGTVY GKW Sbjct: 462 PQRERKSSSSSEDRNRMKTLGRRDSSDDWE----IPDGQITVGQRIGSGSFGTVYKGKWH 517 Query: 213 GTDVAIKRIKKSCFTGRSSEQERLAQEFWREAEILSKLHHPNVVAFYGVVKDGPGGTLAT 392 G DVA+K + + T + Q F E +L K H N++ F G LA Sbjct: 518 G-DVAVKMLNVTAPTPQQ------LQAFKNEVGVLRKTRHVNILLFMGY---STKPQLAI 567 Query: 393 LTEFMVNGSLRHVL 434 +T++ SL H L Sbjct: 568 VTQWCEGSSLYHHL 581
>MOS_APTAU (P87347) Serine/threonine-protein kinase mos (EC 2.7.11.1) (Oocyte| maturation factor mos) (Fragment) Length = 200 Score = 52.0 bits (123), Expect = 8e-07 Identities = 36/97 (37%), Positives = 52/97 (53%), Gaps = 5/97 (5%) Frame = +3 Query: 159 LRELGSGTFGTVYHGKWRGTDVAIKRIKKSCFTGRSSEQERLA--QEFWREAEILSKLHH 332 L+ LGSG FG+VY + G VA+K++KK S + RLA Q FW E + ++L H Sbjct: 5 LQPLGSGGFGSVYKATYHGATVAVKQVKK-------SSKNRLASRQSFWAELNV-ARLQH 56 Query: 333 PNVVAFYGVVKDGPG--GTLAT-LTEFMVNGSLRHVL 434 NVV P +L T + E++ N +L HV+ Sbjct: 57 ANVVRVVAASTCAPASQNSLGTIIMEYVGNITLHHVI 93
>FAK2_HUMAN (Q14289) Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal| adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinas Length = 1009 Score = 52.0 bits (123), Expect = 8e-07 Identities = 39/125 (31%), Positives = 58/125 (46%), Gaps = 5/125 (4%) Frame = +3 Query: 81 AQVMDASLRDSDFEHLQIIKNEDLEELRELGSGTFGTVYHG-----KWRGTDVAIKRIKK 245 A++ D +LR I + ED+ R LG G FG VY G K +VA+K KK Sbjct: 403 AEIPDETLRRPGGPQYGIAR-EDVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKK 461 Query: 246 SCFTGRSSEQERLAQEFWREAEILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLR 425 C ++F EA I+ L HP++V G++++ P + L + G L Sbjct: 462 DCTLDNK-------EKFMSEAVIMKNLDHPHIVKLIGIIEEEPTWIIMELYPY---GELG 511 Query: 426 HVLQR 440 H L+R Sbjct: 512 HYLER 516
>MOS_CHICK (P10741) Serine/threonine-protein kinase mos (EC 2.7.11.1) (Oocyte| maturation factor mos) Length = 349 Score = 52.0 bits (123), Expect = 8e-07 Identities = 36/97 (37%), Positives = 51/97 (52%), Gaps = 5/97 (5%) Frame = +3 Query: 159 LRELGSGTFGTVYHGKWRGTDVAIKRIKKSCFTGRSSEQERLA--QEFWREAEILSKLHH 332 L+ LGSG FG VY + G VA+K++KK S + RLA Q FW E + ++L H Sbjct: 67 LQPLGSGGFGAVYKATYHGVTVAVKQVKK-------SSKNRLASRQSFWAELNV-ARLQH 118 Query: 333 PNVVAFYGVVKDGPG--GTLAT-LTEFMVNGSLRHVL 434 NVV P +L T + E++ N +L HV+ Sbjct: 119 DNVVRVVAASTCAPASQNSLGTIIMEYVGNVTLHHVI 155
>NTRK2_RAT (Q63604) BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B) Length = 821 Score = 52.0 bits (123), Expect = 8e-07 Identities = 39/127 (30%), Positives = 62/127 (48%), Gaps = 7/127 (5%) Frame = +3 Query: 87 VMDASLRDSDFEHLQIIKNEDLEELRELGSGTFGTVYHGKWRGTD-------VAIKRIKK 245 + ++ L+ F +Q IK ++ RELG G FG V+ + VA+K +K Sbjct: 518 ITNSQLKPDTF--VQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKD 575 Query: 246 SCFTGRSSEQERLAQEFWREAEILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLR 425 + R ++F REAE+L+ L H ++V FYGV + G L + E+M +G L Sbjct: 576 ASDNAR--------KDFHREAELLTNLQHEHIVKFYGVCVE--GDPLIMVFEYMKHGDLN 625 Query: 426 HVLQRKG 446 L+ G Sbjct: 626 KFLRAHG 632
>NTRK2_MOUSE (P15209) BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B) Length = 821 Score = 52.0 bits (123), Expect = 8e-07 Identities = 39/127 (30%), Positives = 62/127 (48%), Gaps = 7/127 (5%) Frame = +3 Query: 87 VMDASLRDSDFEHLQIIKNEDLEELRELGSGTFGTVYHGKWRGTD-------VAIKRIKK 245 + ++ L+ F +Q IK ++ RELG G FG V+ + VA+K +K Sbjct: 518 ITNSQLKPDTF--VQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKD 575 Query: 246 SCFTGRSSEQERLAQEFWREAEILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLR 425 + R ++F REAE+L+ L H ++V FYGV + G L + E+M +G L Sbjct: 576 ASDNAR--------KDFHREAELLTNLQHEHIVKFYGVCVE--GDPLIMVFEYMKHGDLN 625 Query: 426 HVLQRKG 446 L+ G Sbjct: 626 KFLRAHG 632
>NTRK2_CHICK (Q91987) BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (Trk-B) Length = 818 Score = 52.0 bits (123), Expect = 8e-07 Identities = 39/127 (30%), Positives = 62/127 (48%), Gaps = 7/127 (5%) Frame = +3 Query: 87 VMDASLRDSDFEHLQIIKNEDLEELRELGSGTFGTVYHGKWRGTD-------VAIKRIKK 245 + ++ L+ F +Q IK ++ RELG G FG V+ + VA+K +K Sbjct: 515 ITNSQLKPDTF--VQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKD 572 Query: 246 SCFTGRSSEQERLAQEFWREAEILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLR 425 + R ++F REAE+L+ L H ++V FYGV + G L + E+M +G L Sbjct: 573 ASDNAR--------KDFHREAELLTNLQHEHIVKFYGVCVE--GDPLIMVFEYMKHGDLN 622 Query: 426 HVLQRKG 446 L+ G Sbjct: 623 KFLRAHG 629
>MIL_AVIMH (P00531) Serine/threonine-protein kinase transforming protein mil| (EC 2.7.11.1) Length = 380 Score = 52.0 bits (123), Expect = 8e-07 Identities = 46/119 (38%), Positives = 63/119 (52%), Gaps = 4/119 (3%) Frame = +3 Query: 105 RDSDFEHLQIIKNEDLEELRELGSGTFGTVYHGKWRGTDVAIKRIKKSCFTGRSSEQERL 284 RDS + + +I +E L R +GSG+FGTVY GKW G DVA+K +K + EQ Sbjct: 69 RDSSY-YWEIEASEVLLSTR-IGSGSFGTVYKGKWHG-DVAVKILK---VVDPTPEQ--- 119 Query: 285 AQEFWREAEILSKLHHPNVVAFYG-VVKDGPGGTLATLTEFMVNGSL---RHVLQRKGQ 449 Q F E +L K H N++ F G + KD LA +T++ SL HV + K Q Sbjct: 120 FQAFRNEVAVLRKTRHVNILLFMGYMTKD----NLAIVTQWCEGSSLYKHLHVQETKFQ 174
>NTRK2_HUMAN (Q16620) BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB) (Trk-B) Length = 822 Score = 52.0 bits (123), Expect = 8e-07 Identities = 39/127 (30%), Positives = 62/127 (48%), Gaps = 7/127 (5%) Frame = +3 Query: 87 VMDASLRDSDFEHLQIIKNEDLEELRELGSGTFGTVYHGKWRGTD-------VAIKRIKK 245 + ++ L+ F +Q IK ++ RELG G FG V+ + VA+K +K Sbjct: 519 ITNSQLKPDTF--VQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKD 576 Query: 246 SCFTGRSSEQERLAQEFWREAEILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLR 425 + R ++F REAE+L+ L H ++V FYGV + G L + E+M +G L Sbjct: 577 ASDNAR--------KDFHREAELLTNLQHEHIVKFYGVCVE--GDPLIMVFEYMKHGDLN 626 Query: 426 HVLQRKG 446 L+ G Sbjct: 627 KFLRAHG 633
>SRC_RSVP (P00526) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 52.0 bits (123), Expect = 8e-07 Identities = 39/118 (33%), Positives = 57/118 (48%), Gaps = 2/118 (1%) Frame = +3 Query: 135 IKNEDLEELRELGSGTFGTVYHGKWRGTD-VAIKRIKKSCFTGRSSEQERLAQEFWREAE 311 I E L +LG G FG V+ G W T VAIK +K + + F +EA+ Sbjct: 261 IPRESLRLEAKLGQGCFGEVWMGTWNDTTRVAIKTLKPGTMS---------PEAFLQEAQ 311 Query: 312 ILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQ-RKGQCPDLPQRLIIA 482 ++ KL H +V Y VV + P + + E+M GSL L+ G+ LPQ + +A Sbjct: 312 VMKKLRHEKLVQLYAVVSEEP---IYIVIEYMSKGSLLDFLKGEMGKYLRLPQLVDMA 366
>ABL_MLVAB (P00521) Tyrosine-protein kinase transforming protein Abl (EC| 2.7.10.2) (V-abl) Length = 746 Score = 51.6 bits (122), Expect = 1e-06 Identities = 32/103 (31%), Positives = 50/103 (48%), Gaps = 2/103 (1%) Frame = +3 Query: 135 IKNEDLEELRELGSGTFGTVYHGKWR--GTDVAIKRIKKSCFTGRSSEQERLAQEFWREA 308 ++ D+ +LG G +G VY G W+ VA+K +K E +EF +EA Sbjct: 123 MERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLK---------EDTMEVEEFLKEA 173 Query: 309 EILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQ 437 ++ ++ HPN+V GV P +TEFM G+L L+ Sbjct: 174 AVMKEIKHPNLVQLLGVCTREP--PFYIITEFMTYGNLLDYLR 214
>EPB1B_XENLA (Q91736) Ephrin type-B receptor 1-B (EC 2.7.10.1) (Tyrosine-protein| kinase receptor XELK) (Fragment) Length = 902 Score = 51.6 bits (122), Expect = 1e-06 Identities = 40/101 (39%), Positives = 53/101 (52%), Gaps = 7/101 (6%) Frame = +3 Query: 168 LGSGTFGTVYHGKW-----RGTDVAIKRIKKSCFTGRSSEQERLAQEFWREAEILSKLHH 332 +G+G FG VY G+ R VAIK +K G S +Q R +F EA I+ + H Sbjct: 543 IGAGEFGEVYKGRLKLPSKREISVAIKTLK----AGYSEKQRR---DFLSEASIMGQFDH 595 Query: 333 PNVVAFYGVV-KDGPGGTLATLTEFMVNGSLRHVL-QRKGQ 449 PN++ GVV K P + +TEFM NG+L L Q GQ Sbjct: 596 PNIIRLEGVVTKSRP---VMIITEFMENGALDSFLRQNDGQ 633
>ABL_FSVHY (P10447) Tyrosine-protein kinase transforming protein Abl (EC| 2.7.10.2) (V-abl) Length = 439 Score = 51.6 bits (122), Expect = 1e-06 Identities = 32/103 (31%), Positives = 50/103 (48%), Gaps = 2/103 (1%) Frame = +3 Query: 135 IKNEDLEELRELGSGTFGTVYHGKWR--GTDVAIKRIKKSCFTGRSSEQERLAQEFWREA 308 ++ D+ +LG G +G VY G W+ VA+K +K E +EF +EA Sbjct: 186 MERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLK---------EDTMEVEEFLKEA 236 Query: 309 EILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQ 437 ++ ++ HPN+V GV P +TEFM G+L L+ Sbjct: 237 AVMKEIKHPNLVQLLGVCTREP--PFYIITEFMTYGNLLDYLR 277
>ABL1_HUMAN (P00519) Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2)| (p150) (c-ABL) (Abelson murine leukemia viral oncogene homolog 1) Length = 1130 Score = 51.6 bits (122), Expect = 1e-06 Identities = 32/103 (31%), Positives = 50/103 (48%), Gaps = 2/103 (1%) Frame = +3 Query: 135 IKNEDLEELRELGSGTFGTVYHGKWR--GTDVAIKRIKKSCFTGRSSEQERLAQEFWREA 308 ++ D+ +LG G +G VY G W+ VA+K +K E +EF +EA Sbjct: 237 MERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLK---------EDTMEVEEFLKEA 287 Query: 309 EILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQ 437 ++ ++ HPN+V GV P +TEFM G+L L+ Sbjct: 288 AVMKEIKHPNLVQLLGVCTREP--PFYIITEFMTYGNLLDYLR 328
>RAF1_RAT (P11345) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 51.6 bits (122), Expect = 1e-06 Identities = 45/119 (37%), Positives = 63/119 (52%), Gaps = 4/119 (3%) Frame = +3 Query: 105 RDSDFEHLQIIKNEDLEELRELGSGTFGTVYHGKWRGTDVAIKRIKKSCFTGRSSEQERL 284 RDS + + +I +E + R +GSG+FGTVY GKW G DVA+K +K + EQ Sbjct: 336 RDSSY-YWEIEASEVMLSTR-IGSGSFGTVYKGKWHG-DVAVKILK---VVDPTPEQ--- 386 Query: 285 AQEFWREAEILSKLHHPNVVAFYG-VVKDGPGGTLATLTEFMVNGSL---RHVLQRKGQ 449 Q F E +L K H N++ F G + KD LA +T++ SL HV + K Q Sbjct: 387 LQAFRNEVAVLRKTRHVNILLFMGYMTKD----NLAIVTQWCEGSSLYKHLHVQETKFQ 441
>RAF1_MOUSE (Q99N57) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 51.6 bits (122), Expect = 1e-06 Identities = 45/119 (37%), Positives = 63/119 (52%), Gaps = 4/119 (3%) Frame = +3 Query: 105 RDSDFEHLQIIKNEDLEELRELGSGTFGTVYHGKWRGTDVAIKRIKKSCFTGRSSEQERL 284 RDS + + +I +E + R +GSG+FGTVY GKW G DVA+K +K + EQ Sbjct: 336 RDSSY-YWEIEASEVMLSTR-IGSGSFGTVYKGKWHG-DVAVKILK---VVDPTPEQ--- 386 Query: 285 AQEFWREAEILSKLHHPNVVAFYG-VVKDGPGGTLATLTEFMVNGSL---RHVLQRKGQ 449 Q F E +L K H N++ F G + KD LA +T++ SL HV + K Q Sbjct: 387 LQAFRNEVAVLRKTRHVNILLFMGYMTKD----NLAIVTQWCEGSSLYKHLHVQETKFQ 441
>EPB1A_XENLA (Q91571) Ephrin type-B receptor 1-A precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor XEK) Length = 985 Score = 51.6 bits (122), Expect = 1e-06 Identities = 40/101 (39%), Positives = 53/101 (52%), Gaps = 7/101 (6%) Frame = +3 Query: 168 LGSGTFGTVYHGKW-----RGTDVAIKRIKKSCFTGRSSEQERLAQEFWREAEILSKLHH 332 +G+G FG VY G+ R VAIK +K G S +Q R +F EA I+ + H Sbjct: 626 IGAGEFGEVYKGRLKLPSKREISVAIKTLK----AGYSEKQRR---DFLSEASIMGQFDH 678 Query: 333 PNVVAFYGVV-KDGPGGTLATLTEFMVNGSLRHVL-QRKGQ 449 PN++ GVV K P + +TEFM NG+L L Q GQ Sbjct: 679 PNIIRLEGVVTKSRP---VMIITEFMENGALDSFLRQNDGQ 716
>RON_MOUSE (Q62190) Macrophage-stimulating protein receptor precursor (EC| 2.7.10.1) (MSP receptor) (p185-Ron) (Stem cell-derived tyrosine kinase) (CDw136 antigen) [Contains: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating prote Length = 1378 Score = 51.6 bits (122), Expect = 1e-06 Identities = 43/162 (26%), Positives = 76/162 (46%), Gaps = 15/162 (9%) Frame = +3 Query: 15 VDNTNLPAPDFEEPKFEEDRTAAQVMDA-SLRDSDFEHLQIIKNEDLEELRE-------- 167 +++T AP+ EE D T+ ++ S+R D + + + + +D+ E Sbjct: 1004 INDTASGAPNHEESSESRDGTSVPLLRTESIRLQDLDRMLLAEVKDVLIPHEQVVIHTDQ 1063 Query: 168 -LGSGTFGTVYHGKWRG-----TDVAIKRIKKSCFTGRSSEQERLAQEFWREAEILSKLH 329 +G G FG VYHG++ T AIK + R +E + + + F RE ++ LH Sbjct: 1064 VIGKGHFGVVYHGEYTDGAQNQTHCAIKSLS------RITEVQEV-EAFLREGLLMRGLH 1116 Query: 330 HPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQRKGQCP 455 HPN++A G++ P G L +M +G L ++ + P Sbjct: 1117 HPNILALIGIMLP-PEGLPRVLLPYMRHGDLLRFIRSPQRNP 1157
>NTRK1_HUMAN (P04629) High affinity nerve growth factor receptor precursor (EC| 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1 transforming tyrosine kinase protein) (p140-TrkA) (Trk-A) Length = 796 Score = 51.6 bits (122), Expect = 1e-06 Identities = 38/111 (34%), Positives = 56/111 (50%), Gaps = 7/111 (6%) Frame = +3 Query: 135 IKNEDLEELRELGSGTFGTVY----HGKWRGTD---VAIKRIKKSCFTGRSSEQERLAQE 293 IK D+ ELG G FG V+ H D VA+K +K++ + R Q+ Sbjct: 505 IKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESAR--------QD 556 Query: 294 FWREAEILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQRKG 446 F REAE+L+ L H ++V F+GV + G L + E+M +G L L+ G Sbjct: 557 FQREAELLTMLQHQHIVRFFGVCTE--GRPLLMVFEYMRHGDLNRFLRSHG 605
>ABL1_MOUSE (P00520) Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2)| (p150) (c-ABL) (Abelson murine leukemia viral oncogene homolog 1) Length = 1123 Score = 51.6 bits (122), Expect = 1e-06 Identities = 32/103 (31%), Positives = 50/103 (48%), Gaps = 2/103 (1%) Frame = +3 Query: 135 IKNEDLEELRELGSGTFGTVYHGKWR--GTDVAIKRIKKSCFTGRSSEQERLAQEFWREA 308 ++ D+ +LG G +G VY G W+ VA+K +K E +EF +EA Sbjct: 237 MERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLK---------EDTMEVEEFLKEA 287 Query: 309 EILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQ 437 ++ ++ HPN+V GV P +TEFM G+L L+ Sbjct: 288 AVMKEIKHPNLVQLLGVCTREP--PFYIITEFMTYGNLLDYLR 328
>DSOR1_DROME (Q24324) Dual specificity mitogen-activated protein kinase kinase| dSOR1 (EC 2.7.12.2) (Downstream of RAF) (MAPKK) Length = 396 Score = 51.2 bits (121), Expect = 1e-06 Identities = 36/116 (31%), Positives = 59/116 (50%) Frame = +3 Query: 111 SDFEHLQIIKNEDLEELRELGSGTFGTVYHGKWRGTDVAIKRIKKSCFTGRSSEQERLAQ 290 S E + + +EDLE+L ELGSG G V K R T + +K + + + Sbjct: 74 SQKEKIGELSDEDLEKLGELGSGNGGVVM--KVRHTHTHLIMARKLI---HLEVKPAIKK 128 Query: 291 EFWREAEILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQRKGQCPD 458 + RE ++L + + P++V FYG G ++ E+M GSL +L+R G+ P+ Sbjct: 129 QILRELKVLHECNFPHIVGFYGAFYS--DGEISICMEYMDGGSLDLILKRAGRIPE 182
>MOS_CICNG (Q90XV8) Serine/threonine-protein kinase mos (EC 2.7.11.1) (Oocyte| maturation factor mos) (Fragment) Length = 200 Score = 51.2 bits (121), Expect = 1e-06 Identities = 36/101 (35%), Positives = 53/101 (52%), Gaps = 5/101 (4%) Frame = +3 Query: 159 LRELGSGTFGTVYHGKWRGTDVAIKRIKKSCFTGRSSEQERLA--QEFWREAEILSKLHH 332 L+ LGSG FG+VY + G VA+K++K +S + RLA Q FW E + ++L H Sbjct: 5 LQPLGSGGFGSVYKATYHGATVAVKQVK-------NSSKNRLASRQSFWAELNV-ARLQH 56 Query: 333 PNVVAFYGVVKDGPG--GTLATLT-EFMVNGSLRHVLQRKG 446 NVV P +L T+ E++ N +L HV+ G Sbjct: 57 NNVVRVVAASTCAPASQNSLGTIVMEYVGNITLHHVIYGTG 97
>FYN_CHICK (Q05876) Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2)| (p59-Fyn) Length = 533 Score = 51.2 bits (121), Expect = 1e-06 Identities = 38/109 (34%), Positives = 54/109 (49%), Gaps = 2/109 (1%) Frame = +3 Query: 162 RELGSGTFGTVYHGKWRG-TDVAIKRIKKSCFTGRSSEQERLAQEFWREAEILSKLHHPN 338 ++LG G F V+ G W G T VAIK +K + S F EA+I+ KL H Sbjct: 271 QKLGQGCFAEVWRGTWNGNTKVAIKTLKPGTMSPES---------FLEEAQIMKKLKHDK 321 Query: 339 VVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQ-RKGQCPDLPQRLIIA 482 +V Y VV P + +TE+M GSL L+ +G+ LP + +A Sbjct: 322 LVQLYAVVSRRP---IYIVTEYMSKGSLLIFLKDGEGRALKLPNLVDMA 367
>RAF1_HUMAN (P04049) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 51.2 bits (121), Expect = 1e-06 Identities = 45/119 (37%), Positives = 63/119 (52%), Gaps = 4/119 (3%) Frame = +3 Query: 105 RDSDFEHLQIIKNEDLEELRELGSGTFGTVYHGKWRGTDVAIKRIKKSCFTGRSSEQERL 284 RDS + + +I +E + R +GSG+FGTVY GKW G DVA+K +K + EQ Sbjct: 336 RDSSY-YWEIEASEVMLSTR-IGSGSFGTVYKGKWHG-DVAVKILK---VVDPTPEQ--- 386 Query: 285 AQEFWREAEILSKLHHPNVVAFYG-VVKDGPGGTLATLTEFMVNGSL---RHVLQRKGQ 449 Q F E +L K H N++ F G + KD LA +T++ SL HV + K Q Sbjct: 387 FQAFRNEVAVLRKTRHVNILLFMGYMTKD----NLAIVTQWCEGSSLYKHLHVQETKFQ 441
>SRC42_DROME (Q9V9J3) Tyrosine-protein kinase Src42A (EC 2.7.10.2) (Dsrc41)| Length = 517 Score = 51.2 bits (121), Expect = 1e-06 Identities = 36/103 (34%), Positives = 51/103 (49%), Gaps = 2/103 (1%) Frame = +3 Query: 135 IKNEDLEELRELGSGTFGTVYHGKWRG-TDVAIKRIKKSCFTGRSSEQERLAQEFWREAE 311 I L+ +R+LGSG FG V+ G W T VAIK +K ++F EA+ Sbjct: 243 IDRTSLKFVRKLGSGQFGDVWEGLWNNTTPVAIKTLKSGTMD---------PKDFLAEAQ 293 Query: 312 ILSKLHHPNVVAFYGV-VKDGPGGTLATLTEFMVNGSLRHVLQ 437 I+ KL H ++ Y V + P + +TE M +GSL LQ Sbjct: 294 IMKKLRHTKLIQLYAVCTVEEP---IYIITELMKHGSLLEYLQ 333
>RAF1_CHICK (P05625) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (RAF-1) (C-RAF) (MIL proto-oncogene serine/threonine-protein kinase) (C-MIL) Length = 647 Score = 51.2 bits (121), Expect = 1e-06 Identities = 45/119 (37%), Positives = 63/119 (52%), Gaps = 4/119 (3%) Frame = +3 Query: 105 RDSDFEHLQIIKNEDLEELRELGSGTFGTVYHGKWRGTDVAIKRIKKSCFTGRSSEQERL 284 RDS + + +I +E + R +GSG+FGTVY GKW G DVA+K +K + EQ Sbjct: 336 RDSSY-YWEIEASEVMLSTR-IGSGSFGTVYKGKWHG-DVAVKILK---VVDPTPEQ--- 386 Query: 285 AQEFWREAEILSKLHHPNVVAFYG-VVKDGPGGTLATLTEFMVNGSL---RHVLQRKGQ 449 Q F E +L K H N++ F G + KD LA +T++ SL HV + K Q Sbjct: 387 FQAFRNEVAVLRKTRHVNILLFMGYMTKD----NLAIVTQWCEGSSLYKHLHVQETKFQ 441
>WNK4_HUMAN (Q96J92) Serine/threonine-protein kinase WNK4 (EC 2.7.11.1)| (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4) Length = 1243 Score = 51.2 bits (121), Expect = 1e-06 Identities = 43/139 (30%), Positives = 61/139 (43%), Gaps = 5/139 (3%) Frame = +3 Query: 39 PDFEEPKFEEDRTAAQVMDASLRDSDFEHLQIIKNEDLEELR---ELGSGTFGTVYHGKW 209 P EP + A + D E + + D L+ E+G G+F TVY G Sbjct: 134 PGSREPLRVPEAVALERRREQEEKEDMETQAVATSPDGRYLKFDIEIGRGSFKTVYRGL- 192 Query: 210 RGTDVAIKRIKKSCFTGRSSEQERLAQEFWREAEILSKLHHPNVVAFYGVVKDGPGG--T 383 TD ++ T + S ER Q F E E+L L HPN+V FY K G Sbjct: 193 -DTDTTVEVAWCELQTRKLSRAER--QRFSEEVEMLKGLQHPNIVRFYDSWKSVLRGQVC 249 Query: 384 LATLTEFMVNGSLRHVLQR 440 + +TE M +G+L+ L+R Sbjct: 250 IVLVTELMTSGTLKTYLRR 268
>YR62_CAEEL (Q20347) Putative serine/threonine-protein kinase F42G10.2 (EC| 2.7.12.2) Length = 363 Score = 51.2 bits (121), Expect = 1e-06 Identities = 35/106 (33%), Positives = 52/106 (49%), Gaps = 2/106 (1%) Frame = +3 Query: 51 EPKFEEDRTAAQVMDASLRDSDFEHLQIIKNEDLEELRELGSGTFGTVY--HGKWRGTDV 224 E E+ + +L+ D EHL + +L++L +G+G FGTVY K G + Sbjct: 33 EKTLPEESVLRSLSTGTLKYPDDEHLYTFSSANLQDLGAIGNGNFGTVYKMRHKETGKLI 92 Query: 225 AIKRIKKSCFTGRSSEQERLAQEFWREAEILSKLHHPNVVAFYGVV 362 A+KRI+ C EQ RL +E I+ PN+V FYG + Sbjct: 93 AVKRIR--CNNIGHREQIRLLRE---HDTIVKSEKGPNIVKFYGAI 133
>ALK_HUMAN (Q9UM73) ALK tyrosine kinase receptor precursor (EC 2.7.10.1)| (Anaplastic lymphoma kinase) (CD246 antigen) Length = 1620 Score = 50.8 bits (120), Expect = 2e-06 Identities = 40/130 (30%), Positives = 59/130 (45%), Gaps = 7/130 (5%) Frame = +3 Query: 105 RDSDFEHLQIIKNEDLEELRELGSGTFGTVYHGKWRG-------TDVAIKRIKKSCFTGR 263 + S L+ + +++ +R LG G FG VY G+ G VA+K + + C Sbjct: 1101 KTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVC---- 1156 Query: 264 SSEQERLAQEFWREAEILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQRK 443 SEQ+ L +F EA I+SK +H N+V GV + L E M G L+ L+ Sbjct: 1157 -SEQDEL--DFLMEALIISKFNHQNIVRCIGVSLQSLPRFI--LLELMAGGDLKSFLRET 1211 Query: 444 GQCPDLPQRL 473 P P L Sbjct: 1212 RPRPSQPSSL 1221
>MOS_NYCNY (Q90XV9) Serine/threonine-protein kinase mos (EC 2.7.11.1) (Oocyte| maturation factor mos) (Fragment) Length = 200 Score = 50.8 bits (120), Expect = 2e-06 Identities = 37/101 (36%), Positives = 52/101 (51%), Gaps = 5/101 (4%) Frame = +3 Query: 159 LRELGSGTFGTVYHGKWRGTDVAIKRIKKSCFTGRSSEQERLA--QEFWREAEILSKLHH 332 L+ LGSG FG+VY + G VA+K++KK S + RLA Q FW E + + L H Sbjct: 5 LQPLGSGGFGSVYKATYHGATVAVKQVKK-------SSKNRLASRQSFWAELNV-AWLQH 56 Query: 333 PNVVAFYGVVKDGPG--GTLAT-LTEFMVNGSLRHVLQRKG 446 NVV P +L T + E++ N +L HV+ G Sbjct: 57 DNVVRVVAASTCAPASQNSLGTIIMEYVGNITLHHVIYGTG 97
>BRAF1_MOUSE (P28028) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Fragment) Length = 328 Score = 50.8 bits (120), Expect = 2e-06 Identities = 33/91 (36%), Positives = 46/91 (50%) Frame = +3 Query: 162 RELGSGTFGTVYHGKWRGTDVAIKRIKKSCFTGRSSEQERLAQEFWREAEILSKLHHPNV 341 + +GSG+FGTVY GKW G DVA+K + + T + Q F E +L K H N+ Sbjct: 23 QRIGSGSFGTVYKGKWHG-DVAVKMLNVTAPTPQQ------LQAFKNEVGVLRKTRHVNI 75 Query: 342 VAFYGVVKDGPGGTLATLTEFMVNGSLRHVL 434 + F G LA +T++ SL H L Sbjct: 76 LLFMGY---STKPQLAIVTQWCEGSSLYHHL 103
>RAF_MSV36 (P00532) Serine/threonine-protein kinase transforming protein raf| (EC 2.7.11.1) Length = 323 Score = 50.8 bits (120), Expect = 2e-06 Identities = 39/98 (39%), Positives = 52/98 (53%), Gaps = 4/98 (4%) Frame = +3 Query: 168 LGSGTFGTVYHGKWRGTDVAIKRIKKSCFTGRSSEQERLAQEFWREAEILSKLHHPNVVA 347 +GSG+FGTVY GKW G DVA+K +K + EQ Q F E +L K H N++ Sbjct: 30 IGSGSFGTVYKGKWHG-DVAVKILK---VVDPTPEQ---LQAFRNEVAVLRKTRHVNILL 82 Query: 348 FYG-VVKDGPGGTLATLTEFMVNGSL---RHVLQRKGQ 449 F G + KD LA +T++ SL HV + K Q Sbjct: 83 FMGYMTKD----NLAIVTQWCEGSSLYKHLHVQETKFQ 116
>ALK_MOUSE (P97793) ALK tyrosine kinase receptor precursor (EC 2.7.10.1)| (Anaplastic lymphoma kinase) (CD246 antigen) Length = 1621 Score = 50.8 bits (120), Expect = 2e-06 Identities = 40/130 (30%), Positives = 60/130 (46%), Gaps = 7/130 (5%) Frame = +3 Query: 105 RDSDFEHLQIIKNEDLEELRELGSGTFGTVYHGKWRG-------TDVAIKRIKKSCFTGR 263 + S L+ + +++ +R LG G FG VY G+ G VA+K + + C Sbjct: 1105 KTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVC---- 1160 Query: 264 SSEQERLAQEFWREAEILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQRK 443 SEQ+ L +F EA I+SK +H N+V GV + L E M G L+ L+ Sbjct: 1161 -SEQDEL--DFLMEALIISKFNHQNIVRCIGVSLQALPRFI--LLELMAGGDLKSFLRET 1215 Query: 444 GQCPDLPQRL 473 P+ P L Sbjct: 1216 RPRPNQPTSL 1225
>JAK2_RAT (Q62689) Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2)| (JAK-2) Length = 1132 Score = 50.4 bits (119), Expect = 2e-06 Identities = 43/151 (28%), Positives = 65/151 (43%), Gaps = 10/151 (6%) Frame = +3 Query: 18 DNTNLPAPDFE----EPKFEEDRTAAQVMDASLRDSDFEHLQIIKNEDLEELRELGSGTF 185 D +L PD+E R A + D D + L+ L++LG G F Sbjct: 804 DLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFE---ERHLKFLQQLGKGNF 860 Query: 186 GTVYHGKW------RGTDVAIKRIKKSCFTGRSSEQERLAQEFWREAEILSKLHHPNVVA 347 G+V ++ G VA+K+++ S E ++F RE EIL L H N+V Sbjct: 861 GSVEMCRYDPLQDNTGEVVAVKKLQHST--------EEHLRDFEREIEILKSLQHDNIVK 912 Query: 348 FYGVVKDGPGGTLATLTEFMVNGSLRHVLQR 440 + GV L + E++ GSLR LQ+ Sbjct: 913 YKGVCYSAGRRNLRLIMEYLPYGSLRDYLQK 943 Score = 41.2 bits (95), Expect = 0.001 Identities = 34/125 (27%), Positives = 59/125 (47%), Gaps = 9/125 (7%) Frame = +3 Query: 135 IKNEDLEELRELGSGTFGTVY---------HGKWRGTDVAIKRIKKSCFTGRSSEQERLA 287 I+NEDL LG GTF ++ +G+ T+V +K + K+ + Sbjct: 540 IRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKA--------HRNYS 591 Query: 288 QEFWREAEILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQRKGQCPDLPQ 467 + F+ A ++S+L H ++V YGV G L + EF+ GSL L++ ++ Sbjct: 592 ESFFEAASMMSQLSHKHLVLNYGVCVCGEENIL--VQEFVKFGSLDTYLKKNKNSINILW 649 Query: 468 RLIIA 482 +L +A Sbjct: 650 KLGVA 654
>JAK2_HUMAN (O60674) Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2)| (JAK-2) Length = 1132 Score = 50.4 bits (119), Expect = 2e-06 Identities = 43/151 (28%), Positives = 65/151 (43%), Gaps = 10/151 (6%) Frame = +3 Query: 18 DNTNLPAPDFE----EPKFEEDRTAAQVMDASLRDSDFEHLQIIKNEDLEELRELGSGTF 185 D +L PD+E R A + D D + L+ L++LG G F Sbjct: 804 DLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFE---ERHLKFLQQLGKGNF 860 Query: 186 GTVYHGKW------RGTDVAIKRIKKSCFTGRSSEQERLAQEFWREAEILSKLHHPNVVA 347 G+V ++ G VA+K+++ S E ++F RE EIL L H N+V Sbjct: 861 GSVEMCRYDPLQDNTGEVVAVKKLQHST--------EEHLRDFEREIEILKSLQHDNIVK 912 Query: 348 FYGVVKDGPGGTLATLTEFMVNGSLRHVLQR 440 + GV L + E++ GSLR LQ+ Sbjct: 913 YKGVCYSAGRRNLKLIMEYLPYGSLRDYLQK 943 Score = 47.0 bits (110), Expect = 3e-05 Identities = 36/125 (28%), Positives = 60/125 (48%), Gaps = 9/125 (7%) Frame = +3 Query: 135 IKNEDLEELRELGSGTFGTVY---------HGKWRGTDVAIKRIKKSCFTGRSSEQERLA 287 I+NEDL LG GTF ++ +G+ T+V +K + K+ + Sbjct: 540 IRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKA--------HRNYS 591 Query: 288 QEFWREAEILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQRKGQCPDLPQ 467 + F+ A ++SKL H ++V YGV G L + EF+ GSL L++ C ++ Sbjct: 592 ESFFEAASMMSKLSHKHLVLNYGVCVCGDENIL--VQEFVKFGSLDTYLKKNKNCINILW 649 Query: 468 RLIIA 482 +L +A Sbjct: 650 KLEVA 654
>JAK1_MOUSE (P52332) Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1)| (JAK-1) Length = 1153 Score = 50.4 bits (119), Expect = 2e-06 Identities = 33/114 (28%), Positives = 55/114 (48%), Gaps = 6/114 (5%) Frame = +3 Query: 150 LEELRELGSGTFGTVY------HGKWRGTDVAIKRIKKSCFTGRSSEQERLAQEFWREAE 311 L+ +R+LG G FG V G G VA+K +K ++ ++ E E Sbjct: 874 LKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKK-------EIE 926 Query: 312 ILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQRKGQCPDLPQRL 473 IL L+H N+V + G+ + G + + EF+ +GSL+ L + +L Q+L Sbjct: 927 ILRNLYHENIVKYKGICMEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQL 980
>JAK2_MOUSE (Q62120) Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2)| (JAK-2) Length = 1129 Score = 50.4 bits (119), Expect = 2e-06 Identities = 43/151 (28%), Positives = 65/151 (43%), Gaps = 10/151 (6%) Frame = +3 Query: 18 DNTNLPAPDFE----EPKFEEDRTAAQVMDASLRDSDFEHLQIIKNEDLEELRELGSGTF 185 D +L PD+E R A + D D + L+ L++LG G F Sbjct: 804 DLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFE---ERHLKFLQQLGKGNF 860 Query: 186 GTVYHGKW------RGTDVAIKRIKKSCFTGRSSEQERLAQEFWREAEILSKLHHPNVVA 347 G+V ++ G VA+K+++ S E ++F RE EIL L H N+V Sbjct: 861 GSVEMCRYDPLQDNTGEVVAVKKLQHST--------EEHLRDFEREIEILKSLQHDNIVK 912 Query: 348 FYGVVKDGPGGTLATLTEFMVNGSLRHVLQR 440 + GV L + E++ GSLR LQ+ Sbjct: 913 YKGVCYSAGRRNLRLIMEYLPYGSLRDYLQK 943 Score = 41.2 bits (95), Expect = 0.001 Identities = 34/125 (27%), Positives = 59/125 (47%), Gaps = 9/125 (7%) Frame = +3 Query: 135 IKNEDLEELRELGSGTFGTVY---------HGKWRGTDVAIKRIKKSCFTGRSSEQERLA 287 I+NEDL LG GTF ++ +G+ T+V +K + K+ + Sbjct: 540 IRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHKTEVLLKVLDKA--------HRNYS 591 Query: 288 QEFWREAEILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQRKGQCPDLPQ 467 + F+ A ++S+L H ++V YGV G L + EF+ GSL L++ ++ Sbjct: 592 ESFFEAASMMSQLSHKHLVLNYGVCVCGEENIL--VQEFVKFGSLDTYLKKNKNSINILW 649 Query: 468 RLIIA 482 +L +A Sbjct: 650 KLGVA 654
>ACK1_HUMAN (Q07912) Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine| kinase non-receptor protein 2) Length = 1036 Score = 50.4 bits (119), Expect = 2e-06 Identities = 31/103 (30%), Positives = 45/103 (43%) Frame = +3 Query: 132 IIKNEDLEELRELGSGTFGTVYHGKWRGTDVAIKRIKKSCFTGRSSEQERLAQEFWREAE 311 +I +DL L +LG G+FG V G+W + C Q +F RE Sbjct: 120 LIGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVN 179 Query: 312 ILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQR 440 + L H N++ YGVV P + +TE GSL L++ Sbjct: 180 AMHSLDHRNLIRLYGVVLTPP---MKMVTELAPLGSLLDRLRK 219
>FAK2_MOUSE (Q9QVP9) Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal| adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinas Length = 1009 Score = 50.4 bits (119), Expect = 2e-06 Identities = 38/133 (28%), Positives = 59/133 (44%), Gaps = 5/133 (3%) Frame = +3 Query: 81 AQVMDASLRDSDFEHLQIIKNEDLEELRELGSGTFGTVYHG-----KWRGTDVAIKRIKK 245 A++ D +LR + + E + R LG G FG VY G K +VA+K KK Sbjct: 403 AEIPDETLRRPGGPQYGVAREEVVLN-RILGEGFFGEVYEGVYTNHKGEKINVAVKTCKK 461 Query: 246 SCFTGRSSEQERLAQEFWREAEILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLR 425 C ++F EA I+ L HP++V G++++ P + L + G L Sbjct: 462 DCTQDNK-------EKFMSEAVIMKNLDHPHIVKLIGIIEEEPTWIIMELYPY---GELG 511 Query: 426 HVLQRKGQCPDLP 464 H L+R +P Sbjct: 512 HYLERNKNSLKVP 524
>EPHB1_RAT (P09759) Ephrin type-B receptor 1 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EPH-2) (ELK) Length = 984 Score = 50.4 bits (119), Expect = 2e-06 Identities = 40/101 (39%), Positives = 53/101 (52%), Gaps = 7/101 (6%) Frame = +3 Query: 168 LGSGTFGTVYHGKW-----RGTDVAIKRIKKSCFTGRSSEQERLAQEFWREAEILSKLHH 332 +G+G FG VY G+ R VAIK +K G S +Q R +F EA I+ + H Sbjct: 625 IGAGEFGEVYKGRLKLPGKREIYVAIKTLK----AGYSEKQRR---DFLSEASIMGQFDH 677 Query: 333 PNVVAFYGVV-KDGPGGTLATLTEFMVNGSLRHVL-QRKGQ 449 PN++ GVV K P + +TEFM NG+L L Q GQ Sbjct: 678 PNIIRLEGVVTKSRP---VMIITEFMENGALDSFLRQNDGQ 715
>EPHB1_HUMAN (P54762) Ephrin type-B receptor 1 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EPH-2) (NET) (HEK6) (ELK) Length = 984 Score = 50.4 bits (119), Expect = 2e-06 Identities = 40/101 (39%), Positives = 53/101 (52%), Gaps = 7/101 (6%) Frame = +3 Query: 168 LGSGTFGTVYHGKW-----RGTDVAIKRIKKSCFTGRSSEQERLAQEFWREAEILSKLHH 332 +G+G FG VY G+ R VAIK +K G S +Q R +F EA I+ + H Sbjct: 625 IGAGEFGEVYKGRLKLPGKREIYVAIKTLK----AGYSEKQRR---DFLSEASIMGQFDH 677 Query: 333 PNVVAFYGVV-KDGPGGTLATLTEFMVNGSLRHVL-QRKGQ 449 PN++ GVV K P + +TEFM NG+L L Q GQ Sbjct: 678 PNIIRLEGVVTKSRP---VMIITEFMENGALDSFLRQNDGQ 715
>EPHB1_CHICK (Q07494) Ephrin type-B receptor 1 (EC 2.7.10.1) (Tyrosine-protein| kinase receptor EPH-2) (Tyrosine kinase CEK6 receptor) (Fragment) Length = 984 Score = 50.4 bits (119), Expect = 2e-06 Identities = 40/101 (39%), Positives = 53/101 (52%), Gaps = 7/101 (6%) Frame = +3 Query: 168 LGSGTFGTVYHGKW-----RGTDVAIKRIKKSCFTGRSSEQERLAQEFWREAEILSKLHH 332 +G+G FG VY G+ R VAIK +K G S +Q R +F EA I+ + H Sbjct: 625 IGAGEFGEVYKGRLKLPGKREIYVAIKTLK----AGYSEKQRR---DFLSEASIMGQFDH 677 Query: 333 PNVVAFYGVV-KDGPGGTLATLTEFMVNGSLRHVL-QRKGQ 449 PN++ GVV K P + +TEFM NG+L L Q GQ Sbjct: 678 PNIIRLEGVVTKSRP---VMIITEFMENGALDSFLRQNDGQ 715
>RON_HUMAN (Q04912) Macrophage-stimulating protein receptor precursor (EC| 2.7.10.1) (MSP receptor) (p185-Ron) (CDw136 antigen) [Contains: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain] Length = 1400 Score = 50.1 bits (118), Expect = 3e-06 Identities = 34/120 (28%), Positives = 60/120 (50%) Frame = +3 Query: 96 ASLRDSDFEHLQIIKNEDLEELRELGSGTFGTVYHGKWRGTDVAIKRIKKSCFTGRSSEQ 275 A ++D H +++ + D R +G G FG VYHG++ D A RI+ + + + Sbjct: 1068 AEVKDVLIPHERVVTHSD----RVIGKGHFGVVYHGEY--IDQAQNRIQCAIKSLSRITE 1121 Query: 276 ERLAQEFWREAEILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQRKGQCP 455 + + F RE ++ L+HPNV+A G++ P G L +M +G L ++ + P Sbjct: 1122 MQQVEAFLREGLLMRGLNHPNVLALIGIMLP-PEGLPHVLLPYMCHGDLLQFIRSPQRNP 1180
>TYK2_MOUSE (Q9R117) Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2)| Length = 1180 Score = 50.1 bits (118), Expect = 3e-06 Identities = 41/131 (31%), Positives = 62/131 (47%), Gaps = 6/131 (4%) Frame = +3 Query: 108 DSDFEHLQIIKNEDLEELRELGSGTFGTV----YHGKWRGTD--VAIKRIKKSCFTGRSS 269 DS + L+++R+LG G FG V Y GT VA+K +K+ C Sbjct: 876 DSPASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKEGC------ 929 Query: 270 EQERLAQEFWREAEILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQRKGQ 449 +L + RE EIL L+H ++V + G +D ++ + E++ GSLR L R Sbjct: 930 -GPQLRSGWQREIEILRTLYHEHIVKYKGCCEDQGEKSVQLVMEYVPLGSLRDYLPR--H 986 Query: 450 CPDLPQRLIIA 482 C L Q L+ A Sbjct: 987 CVGLAQLLLFA 997 Score = 36.6 bits (83), Expect = 0.036 Identities = 33/132 (25%), Positives = 61/132 (46%), Gaps = 16/132 (12%) Frame = +3 Query: 135 IKNEDLEELRELGSGTFGTVYHGKWRGTDVAIKRIKKSCFT---GRSSEQER-------- 281 + +++ +L LG GT VY G R ++ C G S +Q R Sbjct: 580 VHQDEITQLSHLGQGTRTNVYEGLLRVGGPDEGKVDNGCPPEPGGTSGQQLRVVLKVLDP 639 Query: 282 ----LAQEFWREAEILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQR-KG 446 +A F+ A ++S++ H ++ +GV G + +TEF+ +G L L+R +G Sbjct: 640 SHHDIALAFYEXASLMSQVSHMHLAFLHGVCVRGSENII--VTEFVEHGPLDVWLRRQRG 697 Query: 447 QCPDLPQRLIIA 482 Q P + ++++A Sbjct: 698 QVP-MTWKMVVA 708
>KPEL_DROME (Q05652) Probable serine/threonine-protein kinase pelle (EC| 2.7.11.1) Length = 501 Score = 50.1 bits (118), Expect = 3e-06 Identities = 34/98 (34%), Positives = 51/98 (52%), Gaps = 2/98 (2%) Frame = +3 Query: 168 LGSGTFGTVYHGKWRGTDVAIKRIKKSCFTGRSSEQERL-AQEFWREAEILSKLHHPNVV 344 LG G FG VY GKW+ DVAIK + + + +Q+ + Q+ + E + L+ + H N++ Sbjct: 219 LGQGGFGDVYRGKWKQLDVAIKVMN---YRSPNIDQKMVELQQSYNELKYLNSIRHDNIL 275 Query: 345 AFYGVVKDGPGGTLATLTEFMVNGSLRHVLQ-RKGQCP 455 A YG GG + + M GSL L+ K Q P Sbjct: 276 ALYGY--SIKGGKPCLVYQLMKGGSLEARLRAHKAQNP 311
>CDC2_CHICK (P13863) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 303 Score = 50.1 bits (118), Expect = 3e-06 Identities = 27/75 (36%), Positives = 43/75 (57%), Gaps = 2/75 (2%) Frame = +3 Query: 144 EDLEELRELGSGTFGTVYHGKWRGTD--VAIKRIKKSCFTGRSSEQERLAQEFWREAEIL 317 ED ++ ++G GT+G VY G+ + T VA+K+I+ SE+E + RE +L Sbjct: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLE------SEEEGVPSTAIREISLL 55 Query: 318 SKLHHPNVVAFYGVV 362 +LHHPN+V V+ Sbjct: 56 KELHHPNIVCLQDVL 70
>STK_HYDAT (P17713) Tyrosine-protein kinase STK (EC 2.7.10.2) (P57-STK)| Length = 509 Score = 50.1 bits (118), Expect = 3e-06 Identities = 34/103 (33%), Positives = 49/103 (47%), Gaps = 1/103 (0%) Frame = +3 Query: 135 IKNEDLEELRELGSGTFGTVYHGKWRG-TDVAIKRIKKSCFTGRSSEQERLAQEFWREAE 311 I E L R+LG+G FG V+ G W T VA+K +K + S F EA Sbjct: 235 IPRESLRLNRKLGAGQFGEVWAGVWNNTTQVAVKTLKPGTMSPAS---------FLDEAG 285 Query: 312 ILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQR 440 ++ KL H ++V Y + D + +TE+M GSL L + Sbjct: 286 VMKKLRHKHLVQLYAICSDRE--PIYIVTEYMSGGSLLDYLSK 326
>FPS_DROME (P18106) Tyrosine-protein kinase Fps85D (EC 2.7.10.2) (dFer)| Length = 1325 Score = 50.1 bits (118), Expect = 3e-06 Identities = 40/120 (33%), Positives = 56/120 (46%), Gaps = 12/120 (10%) Frame = +3 Query: 135 IKNEDLEELRELGSGTFGTVYHGKWRGT--DVAIKRIKKSCFTGRSSEQERLAQEFWREA 308 + N+D+ L +G G FG VY K + T DVA+ K+C EQ+R +F +E Sbjct: 1058 LSNDDVVLLERIGRGNFGDVYKAKLKSTKLDVAV----KTCRMTLPDEQKR---KFLQEG 1110 Query: 309 EILSKLHHPNVVAFYGV-VKDGP---------GGTLATLTEFMVNGSLRHVLQRKGQCPD 458 IL + HPN+V G+ V+ P GG+L T NG Q+ G C D Sbjct: 1111 RILKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSNGLTTR--QQMGMCRD 1168
>M3K3_ARATH (O22042) Mitogen-activated protein kinase kinase kinase 3 (EC| 2.7.11.25) (Arabidospsis NPK1-related protein kinase 3) Length = 651 Score = 50.1 bits (118), Expect = 3e-06 Identities = 30/99 (30%), Positives = 52/99 (52%), Gaps = 2/99 (2%) Frame = +3 Query: 168 LGSGTFGTVYHGKW--RGTDVAIKRIKKSCFTGRSSEQERLAQEFWREAEILSKLHHPNV 341 +G G FG VY G G +AIK++ + + + + +E E ++L L HPN+ Sbjct: 74 IGCGAFGRVYMGMNLDSGELLAIKQVLIAPSSASKEKTQGHIRELEEEVQLLKNLSHPNI 133 Query: 342 VAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQRKGQCPD 458 V + G V++ +L L EF+ GS+ +L++ G P+ Sbjct: 134 VRYLGTVRE--SDSLNILMEFVPGGSISSLLEKFGSFPE 170
>7LESS_DROME (P13368) Protein sevenless (EC 2.7.10.1)| Length = 2554 Score = 49.7 bits (117), Expect = 4e-06 Identities = 40/124 (32%), Positives = 59/124 (47%), Gaps = 6/124 (4%) Frame = +3 Query: 84 QVMDASLRDSDFEHLQIIKNEDLEELRELGSGTFGTVYHGKWRGTD------VAIKRIKK 245 + +L D+D L I L+ LR LGSG FG VY G+ + D VAIK ++K Sbjct: 2187 RAFSTTLSDADIALLPQINWSQLKLLRFLGSGAFGEVYEGQLKTEDSEEPQRVAIKSLRK 2246 Query: 246 SCFTGRSSEQERLAQEFWREAEILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLR 425 +SE L Q EA+++S H N+V G+ D +++ + E M G L Sbjct: 2247 G-----ASEFAELLQ----EAQLMSNFKHENIVCLVGICFDTE--SISLIMEHMEAGDLL 2295 Query: 426 HVLQ 437 L+ Sbjct: 2296 SYLR 2299
>7LESS_DROVI (P20806) Protein sevenless (EC 2.7.10.1)| Length = 2594 Score = 49.7 bits (117), Expect = 4e-06 Identities = 41/125 (32%), Positives = 59/125 (47%), Gaps = 6/125 (4%) Frame = +3 Query: 81 AQVMDASLRDSDFEHLQIIKNEDLEELRELGSGTFGTVYHGKWRGTD------VAIKRIK 242 ++ SL D+D L I L LR LGSG FG VY G+ + D VAIK ++ Sbjct: 2201 SRTFSMSLSDADIALLPQINWNRLTLLRFLGSGAFGEVYEGQLQAEDEAQPQRVAIKSLR 2260 Query: 243 KSCFTGRSSEQERLAQEFWREAEILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSL 422 K +SE L Q EA+++S H N+V G+ D +++ + E M G L Sbjct: 2261 KG-----ASEFAELLQ----EAQLMSNFKHENIVCLIGICCD--TDSISLIMEHMEAGDL 2309 Query: 423 RHVLQ 437 L+ Sbjct: 2310 LSYLR 2314
>JAK1_HUMAN (P23458) Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1)| (JAK-1) Length = 1142 Score = 49.7 bits (117), Expect = 4e-06 Identities = 32/113 (28%), Positives = 56/113 (49%), Gaps = 5/113 (4%) Frame = +3 Query: 150 LEELRELGSGTFGTVYHGKW-----RGTDVAIKRIKKSCFTGRSSEQERLAQEFWREAEI 314 L+ +R+LG G FG V ++ G VA+K +K ++ ++ E EI Sbjct: 864 LKRIRDLGEGHFGKVELCRYDPEDNTGEQVAVKSLKPESGGNHIADLKK-------EIEI 916 Query: 315 LSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQRKGQCPDLPQRL 473 L L+H N+V + G+ + G + + EF+ +GSL+ L + +L Q+L Sbjct: 917 LRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQL 969
>MOS_XENLA (P12965) Serine/threonine-protein kinase mos (EC 2.7.11.1)| (pp39-mos) Length = 359 Score = 49.7 bits (117), Expect = 4e-06 Identities = 36/106 (33%), Positives = 52/106 (49%), Gaps = 5/106 (4%) Frame = +3 Query: 159 LRELGSGTFGTVYHGKWRGTDVAIKRIKKSCFTGRSSEQERLAQEFWREAEILSKLHHPN 338 L LGSG FG+VY +RG VA+K++K+S +S Q FW E ++L HP+ Sbjct: 66 LEPLGSGGFGSVYRATYRGETVALKKVKRSTKNSLASR-----QSFWAELN-AARLRHPH 119 Query: 339 VVAFYGVVKDGPG-----GTLATLTEFMVNGSLRHVLQRKGQCPDL 461 VV PG GT+ + E+ G+L + G+ P L Sbjct: 120 VVRVVAASASCPGDPGCPGTI--IMEYTGTGTLHQRIY--GRSPPL 161
>EPHA8_RAT (P29321) Ephrin type-A receptor 8 (EC 2.7.10.1) (Tyrosine-protein| kinase receptor EEK) (EPH- and ELK-related kinase) (Fragment) Length = 372 Score = 49.7 bits (117), Expect = 4e-06 Identities = 34/90 (37%), Positives = 47/90 (52%), Gaps = 5/90 (5%) Frame = +3 Query: 168 LGSGTFGTVYHGKW-----RGTDVAIKRIKKSCFTGRSSEQERLAQEFWREAEILSKLHH 332 +GSG G V +G+ R VAIK +K + ER Q+F REA I+ + H Sbjct: 8 IGSGESGEVCYGRLQVPGQRDVPVAIKALK-------AGYTERQRQDFLREAAIMGQFDH 60 Query: 333 PNVVAFYGVVKDGPGGTLATLTEFMVNGSL 422 PN++ GVV G + +TE+M NGSL Sbjct: 61 PNIIRLEGVVTRGRLAMI--VTEYMENGSL 88
>M3K10_HUMAN (Q02779) Mitogen-activated protein kinase kinase kinase 10 (EC| 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST) Length = 954 Score = 49.7 bits (117), Expect = 4e-06 Identities = 31/95 (32%), Positives = 47/95 (49%) Frame = +3 Query: 150 LEELRELGSGTFGTVYHGKWRGTDVAIKRIKKSCFTGRSSEQERLAQEFWREAEILSKLH 329 LEE+ +G G FG VY WRG +VA+K + + A++ +EA + L Sbjct: 100 LEEI--IGVGGFGKVYRALWRGEEVAVKAAR----LDPEKDPAVTAEQVCQEARLFGALQ 153 Query: 330 HPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVL 434 HPN++A G + P L + E+ G+L VL Sbjct: 154 HPNIIALRGACLNPP--HLCLVMEYARGGALSRVL 186
>IPL1_YEAST (P38991) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) (Increase-in-ploidy protein 1) Length = 367 Score = 49.7 bits (117), Expect = 4e-06 Identities = 38/131 (29%), Positives = 67/131 (51%), Gaps = 2/131 (1%) Frame = +3 Query: 75 TAAQVMDASLRDSDFEHLQIIKNEDLEELRELGSGTFGTVYHGKWRGTDV--AIKRIKKS 248 T+++++ + + F+ L + +D E ++LG G FG VY + R T A+K ++K Sbjct: 82 TSSKMIHENKKLPKFKSLSL---DDFELGKKLGKGKFGKVYCVRHRSTGYICALKVMEKE 138 Query: 249 CFTGRSSEQERLAQEFWREAEILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRH 428 + L ++F RE EI + L+HPN+ YG D + L E++VNG + Sbjct: 139 EII-----KYNLQKQFRREVEIQTSLNHPNLTKSYGYFHDEK--RVYLLMEYLVNGEMYK 191 Query: 429 VLQRKGQCPDL 461 +L+ G D+ Sbjct: 192 LLRLHGPFNDI 202
>IRAK4_HUMAN (Q9NWZ3) Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1)| (IRAK-4) (NY-REN-64 antigen) Length = 460 Score = 49.7 bits (117), Expect = 4e-06 Identities = 38/133 (28%), Positives = 57/133 (42%), Gaps = 5/133 (3%) Frame = +3 Query: 39 PDFEEPKFEEDRTAAQVMDASLRDSDFEHLQIIKNEDLEEL-----RELGSGTFGTVYHG 203 PD P + + +V D F L+ + N E ++G G FG VY G Sbjct: 148 PDSSSP----ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKG 203 Query: 204 KWRGTDVAIKRIKKSCFTGRSSEQERLAQEFWREAEILSKLHHPNVVAFYGVVKDGPGGT 383 T VA+K++ E L Q+F +E ++++K H N+V G D G Sbjct: 204 YVNNTTVAVKKLAAMV----DITTEELKQQFDQEIKVMAKCQHENLVELLGFSSD--GDD 257 Query: 384 LATLTEFMVNGSL 422 L + +M NGSL Sbjct: 258 LCLVYVYMPNGSL 270
>ERBB4_HUMAN (Q15303) Receptor tyrosine-protein kinase erbB-4 precursor (EC| 2.7.10.1) (p180erbB4) (Tyrosine kinase-type cell surface receptor HER4) Length = 1308 Score = 49.3 bits (116), Expect = 5e-06 Identities = 32/99 (32%), Positives = 51/99 (51%) Frame = +3 Query: 126 LQIIKNEDLEELRELGSGTFGTVYHGKWRGTDVAIKRIKKSCFTGRSSEQERLAQEFWRE 305 L+I+K +L+ ++ LGSG FGTVY G W +K I + + + EF E Sbjct: 710 LRILKETELKRVKVLGSGAFGTVYKGIWVPEGETVK-IPVAIKILNETTGPKANVEFMDE 768 Query: 306 AEILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSL 422 A I++ + HP++V GV T+ +T+ M +G L Sbjct: 769 ALIMASMDHPHLVRLLGVCL---SPTIQLVTQLMPHGCL 804
>IPL1_ASHGO (Q755C4) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) Length = 367 Score = 49.3 bits (116), Expect = 5e-06 Identities = 38/114 (33%), Positives = 55/114 (48%), Gaps = 2/114 (1%) Frame = +3 Query: 126 LQIIKNEDLEELRELGSGTFGTVYHGKW--RGTDVAIKRIKKSCFTGRSSEQERLAQEFW 299 LQ +K D E + LG G FG VY + G A+K ++K + Q + ++F Sbjct: 101 LQNLKLADFEIGKVLGKGKFGRVYCVRHIESGFVCALKAMEK-----KDIIQYNIEKQFR 155 Query: 300 REAEILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQRKGQCPDL 461 RE EI S L HPN+ YG D + L E++VNG L L+ + D+ Sbjct: 156 REVEIQSSLRHPNLTQLYGYFHDEK--RVYLLMEYLVNGELYKHLKGRSHFNDV 207
>M3K12_HUMAN (Q12852) Mitogen-activated protein kinase kinase kinase 12 (EC| 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK) Length = 859 Score = 49.3 bits (116), Expect = 5e-06 Identities = 37/119 (31%), Positives = 57/119 (47%) Frame = +3 Query: 120 EHLQIIKNEDLEELRELGSGTFGTVYHGKWRGTDVAIKRIKKSCFTGRSSEQERLAQEFW 299 E L + E++ +L+ +GSG G V+ G++ G +VA+K+++ T Sbjct: 115 EDLWEVPFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKET-------------- 160 Query: 300 REAEILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQRKGQCPDLPQRLI 476 + + L KL HPN++ F GV P L EF G L VL R G+ P P L+ Sbjct: 161 -DIKHLRKLKHPNIITFKGVCTQAP--CYCILMEFCAQGQLYEVL-RAGR-PVTPSLLV 214
>NTRK1_CHICK (Q91009) High affinity nerve growth factor receptor precursor (EC| 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (Trk-A) (Fragment) Length = 778 Score = 49.3 bits (116), Expect = 5e-06 Identities = 37/111 (33%), Positives = 56/111 (50%), Gaps = 7/111 (6%) Frame = +3 Query: 135 IKNEDLEELRELGSGTFGTVYHGKW-------RGTDVAIKRIKKSCFTGRSSEQERLAQE 293 ++ D+ ELG G FG V+ + T VA+K +K+ +E RL + Sbjct: 488 VQRRDIVLKWELGEGAFGKVFLAECSHLLPEQEKTLVAVKALKEV------TENARL--D 539 Query: 294 FWREAEILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQRKG 446 F REAE+L+ L H ++V FYGV + G L + E+M +G L L+ G Sbjct: 540 FQREAELLTVLQHEHIVKFYGVCTE--GDPLIMVFEYMKHGDLNRFLRSHG 588
>M3K12_RAT (Q63796) Mitogen-activated protein kinase kinase kinase 12 (EC| 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK) Length = 888 Score = 49.3 bits (116), Expect = 5e-06 Identities = 37/119 (31%), Positives = 57/119 (47%) Frame = +3 Query: 120 EHLQIIKNEDLEELRELGSGTFGTVYHGKWRGTDVAIKRIKKSCFTGRSSEQERLAQEFW 299 E L + E++ +L+ +GSG G V+ G++ G +VA+K+++ T Sbjct: 148 EDLWEVPFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKET-------------- 193 Query: 300 REAEILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQRKGQCPDLPQRLI 476 + + L KL HPN++ F GV P L EF G L VL R G+ P P L+ Sbjct: 194 -DIKHLRKLKHPNIITFKGVCTQAP--CYCILMEFCAQGQLYEVL-RAGR-PVTPSLLV 247
>M3K12_MOUSE (Q60700) Mitogen-activated protein kinase kinase kinase 12 (EC| 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK) Length = 888 Score = 49.3 bits (116), Expect = 5e-06 Identities = 37/119 (31%), Positives = 57/119 (47%) Frame = +3 Query: 120 EHLQIIKNEDLEELRELGSGTFGTVYHGKWRGTDVAIKRIKKSCFTGRSSEQERLAQEFW 299 E L + E++ +L+ +GSG G V+ G++ G +VA+K+++ T Sbjct: 148 EDLWEVPFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKET-------------- 193 Query: 300 REAEILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQRKGQCPDLPQRLI 476 + + L KL HPN++ F GV P L EF G L VL R G+ P P L+ Sbjct: 194 -DIKHLRKLKHPNIITFKGVCTQAP--CYCILMEFCAQGQLYEVL-RAGR-PVTPSLLV 247
>M3K11_HUMAN (Q16584) Mitogen-activated protein kinase kinase kinase 11 (EC| 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline-rich kinase) Length = 847 Score = 49.3 bits (116), Expect = 5e-06 Identities = 33/95 (34%), Positives = 46/95 (48%) Frame = +3 Query: 150 LEELRELGSGTFGTVYHGKWRGTDVAIKRIKKSCFTGRSSEQERLAQEFWREAEILSKLH 329 LEE+ +G G FG VY G WRG VA+K ++ S E + Q EA + + L Sbjct: 119 LEEV--IGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQ----EARLFAMLA 172 Query: 330 HPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVL 434 HPN++A V + P L + E+ G L L Sbjct: 173 HPNIIALKAVCLEEP--NLCLVMEYAAGGPLSRAL 205
>ACK2_BOVIN (O02742) Activated CDC42 kinase 2 (EC 2.7.10.2) (ACK-2)| Length = 747 Score = 48.9 bits (115), Expect = 7e-06 Identities = 30/103 (29%), Positives = 44/103 (42%) Frame = +3 Query: 132 IIKNEDLEELRELGSGTFGTVYHGKWRGTDVAIKRIKKSCFTGRSSEQERLAQEFWREAE 311 +I +DL +LG G+FG V G+W + C Q +F RE Sbjct: 120 LIGEKDLHLFEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVN 179 Query: 312 ILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQR 440 + L H N++ YGVV P + +TE GSL L++ Sbjct: 180 AMHSLDHRNLIRLYGVVLTPP---MKMVTELAPLGSLLDRLRK 219
>M3K1_HUMAN (Q13233) Mitogen-activated protein kinase kinase kinase 1 (EC| 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1) (Fragment) Length = 1495 Score = 48.9 bits (115), Expect = 7e-06 Identities = 30/103 (29%), Positives = 50/103 (48%), Gaps = 2/103 (1%) Frame = +3 Query: 144 EDLEELR--ELGSGTFGTVYHGKWRGTDVAIKRIKKSCFTGRSSEQERLAQEFWREAEIL 317 ED E L+ ++G G F + Y + GT + + + SSEQE + + E ++ Sbjct: 1222 EDTEWLKGQQIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMM 1281 Query: 318 SKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQRKG 446 S L+HPN++ G + L E+M GS+ H+L + G Sbjct: 1282 SHLNHPNIIRMLGATCEKSNYNL--FIEWMAGGSVAHLLSKYG 1322
>KCC1_YEAST (P27466) Calcium/calmodulin-dependent protein kinase I (EC| 2.7.11.17) Length = 446 Score = 48.9 bits (115), Expect = 7e-06 Identities = 28/65 (43%), Positives = 37/65 (56%), Gaps = 2/65 (3%) Frame = +3 Query: 162 RELGSGTFGTVYHGK--WRGTDVAIKRIKKSCFTGRSSEQERLAQEFWREAEILSKLHHP 335 + LG+GTFG V K G DVA+K + K G + E L + E +IL +LHHP Sbjct: 41 KTLGAGTFGVVRQAKNTETGEDVAVKILIKKALKGNKVQLEAL----YDELDILQRLHHP 96 Query: 336 NVVAF 350 N+VAF Sbjct: 97 NIVAF 101
>ERBB4_RAT (Q62956) Receptor tyrosine-protein kinase erbB-4 precursor (EC| 2.7.10.1) Length = 1308 Score = 48.9 bits (115), Expect = 7e-06 Identities = 32/99 (32%), Positives = 51/99 (51%) Frame = +3 Query: 126 LQIIKNEDLEELRELGSGTFGTVYHGKWRGTDVAIKRIKKSCFTGRSSEQERLAQEFWRE 305 L+I+K +L+ ++ LGSG FGTVY G W +K I + + + EF E Sbjct: 710 LRILKETELKRVKVLGSGAFGTVYKGIWVPEGETVK-IPVAIKILNETTGPKANVEFMDE 768 Query: 306 AEILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSL 422 A I++ + HP++V GV T+ +T+ M +G L Sbjct: 769 ALIMASVDHPHLVRLLGVCL---SPTIQLVTQLMPHGCL 804
>CDC2_CAEEL (P34556) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) Length = 332 Score = 48.9 bits (115), Expect = 7e-06 Identities = 29/74 (39%), Positives = 41/74 (55%), Gaps = 2/74 (2%) Frame = +3 Query: 147 DLEELRELGSGTFGTVYHGKWRGTD--VAIKRIKKSCFTGRSSEQERLAQEFWREAEILS 320 D +L ++G GT+G VY GK R T+ VA+K+I+ SE E + RE +L Sbjct: 21 DFTKLEKIGEGTYGVVYKGKNRRTNAMVAMKKIR------LESEDEGVPSTAVREISLLK 74 Query: 321 KLHHPNVVAFYGVV 362 +L HPNVV V+ Sbjct: 75 ELQHPNVVGLEAVI 88
>ACK1_MOUSE (O54967) Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1)| (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2) Length = 1055 Score = 48.9 bits (115), Expect = 7e-06 Identities = 31/103 (30%), Positives = 45/103 (43%) Frame = +3 Query: 132 IIKNEDLEELRELGSGTFGTVYHGKWRGTDVAIKRIKKSCFTGRSSEQERLAQEFWREAE 311 +I +DL L +LG G+FG V G+W + C Q +F RE Sbjct: 120 LIGEKDLRLLEKLGDGSFGVVRRGEWDAPAGKTVSVAVKCLKPDVLSQPEAMDDFIREVN 179 Query: 312 ILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQR 440 + L H N++ YGVV P + +TE GSL L++ Sbjct: 180 AMHSLDHRNLIRLYGVVLTLP---MKMVTELAPLGSLLDRLRK 219
>PTK6_HUMAN (Q13882) Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor| kinase) (Tyrosine-protein kinase BRK) Length = 451 Score = 48.5 bits (114), Expect = 9e-06 Identities = 33/99 (33%), Positives = 48/99 (48%), Gaps = 1/99 (1%) Frame = +3 Query: 144 EDLEELRELGSGTFGTVYHGKWRG-TDVAIKRIKKSCFTGRSSEQERLAQEFWREAEILS 320 E+ R+LGSG FG V+ G W+ VAIK I + + Q E + + Sbjct: 189 EEFTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQS--------EIQAMK 240 Query: 321 KLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQ 437 KL H +++A Y VV G + +TE M GSL +L+ Sbjct: 241 KLRHKHILALYAVV--SVGDPVYIITELMAKGSLLELLR 277
>EGFR_MOUSE (Q01279) Epidermal growth factor receptor precursor (EC 2.7.10.1)| Length = 1210 Score = 48.5 bits (114), Expect = 9e-06 Identities = 33/121 (27%), Positives = 58/121 (47%), Gaps = 2/121 (1%) Frame = +3 Query: 66 EDRTAAQVMDASLRDSDFEHLQIIKNEDLEELRELGSGTFGTVYHGKW--RGTDVAIKRI 239 ++R + + S + HL+I+K + ++++ LGSG FGTVY G W G V I Sbjct: 686 QERELVEPLTPSGEAPNQAHLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVA 745 Query: 240 KKSCFTGRSSEQERLAQEFWREAEILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGS 419 K R + + +E EA +++ + +P+V G+ T+ +T+ M G Sbjct: 746 IKEL---REATSPKANKEILDEAYVMASVDNPHVCRLLGICLT---STVQLITQLMPYGC 799 Query: 420 L 422 L Sbjct: 800 L 800
>WNK2_HUMAN (Q9Y3S1) Serine/threonine-protein kinase WNK2 (EC 2.7.11.1)| (Protein kinase with no lysine 2) (Protein kinase, lysine-deficient 2) Length = 2297 Score = 48.5 bits (114), Expect = 9e-06 Identities = 43/133 (32%), Positives = 61/133 (45%), Gaps = 2/133 (1%) Frame = +3 Query: 48 EEPKFEEDRTAAQVMDASLRDSDFEHLQIIKNEDLEELRELGSGTFGTVYHGKWRGTDVA 227 +EP+ EED A+ D F I ELG G+F TVY G T V Sbjct: 171 DEPEEEEDDEDDLKAVATSLDGRFLKFDI----------ELGRGSFKTVYKGLDTETWVE 220 Query: 228 IKRIKKSCFTGRSSEQERLAQEFWREAEILSKLHHPNVVAFYGVVKDGPGG--TLATLTE 401 + + + ++ ER Q F EAE+L L HPN+V FY + G + +TE Sbjct: 221 VAWCELQ--DRKLTKLER--QRFKEEAEMLKGLQHPNIVRFYDFWESSAKGKRCIVLVTE 276 Query: 402 FMVNGSLRHVLQR 440 M +G+L+ L+R Sbjct: 277 LMTSGTLKTYLKR 289
>EPHB4_MOUSE (P54761) Ephrin type-B receptor 4 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor MDK-2) (Developmental kinase 2) (Tyrosine kinase MYK-1) Length = 987 Score = 48.5 bits (114), Expect = 9e-06 Identities = 34/95 (35%), Positives = 51/95 (53%), Gaps = 5/95 (5%) Frame = +3 Query: 168 LGSGTFGTVYHGKWRGTD-----VAIKRIKKSCFTGRSSEQERLAQEFWREAEILSKLHH 332 +G+G FG V G+ + VAIK +K G +E++R +EF EA I+ + H Sbjct: 621 IGAGEFGEVCRGRLKAPGKKESCVAIKTLK-----GGYTERQR--REFLSEASIMGQFEH 673 Query: 333 PNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQ 437 PN++ GVV + + LTEFM NG+L L+ Sbjct: 674 PNIIRLEGVVTNSV--PVMILTEFMENGALDSFLR 706
>EPHB4_HUMAN (P54760) Ephrin type-B receptor 4 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor HTK) Length = 987 Score = 48.5 bits (114), Expect = 9e-06 Identities = 34/95 (35%), Positives = 51/95 (53%), Gaps = 5/95 (5%) Frame = +3 Query: 168 LGSGTFGTVYHGKWRGTD-----VAIKRIKKSCFTGRSSEQERLAQEFWREAEILSKLHH 332 +G+G FG V G+ + VAIK +K G +E++R +EF EA I+ + H Sbjct: 621 IGAGEFGEVCRGRLKAPGKKESCVAIKTLK-----GGYTERQR--REFLSEASIMGQFEH 673 Query: 333 PNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQ 437 PN++ GVV + + LTEFM NG+L L+ Sbjct: 674 PNIIRLEGVVTNSM--PVMILTEFMENGALDSFLR 706
>WNK1_MOUSE (P83741) Serine/threonine-protein kinase WNK1 (EC 2.7.11.1)| (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1) Length = 2377 Score = 48.1 bits (113), Expect = 1e-05 Identities = 40/124 (32%), Positives = 60/124 (48%), Gaps = 8/124 (6%) Frame = +3 Query: 93 DASLRDSDFEHLQ---IIKNEDLEELR---ELGSGTFGTVYHGKWRGTDVAIKRIKKSCF 254 D S + D E L+ + + D L+ E+G G+F TVY G T V + + Sbjct: 196 DRSQQQDDIEELETKAVGMSNDGRFLKFDIEIGRGSFKTVYKGLDTETTVEVAWCELQDR 255 Query: 255 TGRSSEQERLAQEFWREAEILSKLHHPNVVAFYGVVKDGPGG--TLATLTEFMVNGSLRH 428 SE++R F EAE+L L HPN+V FY + G + +TE M +G+L+ Sbjct: 256 KLTKSERQR----FKEEAEMLKGLQHPNIVRFYDSWESTVKGKKCIVLVTELMTSGTLKT 311 Query: 429 VLQR 440 L+R Sbjct: 312 YLKR 315
>CDC7_SCHPO (P41892) Cell division control protein 7 (EC 2.7.11.1)| Length = 1062 Score = 48.1 bits (113), Expect = 1e-05 Identities = 31/99 (31%), Positives = 48/99 (48%), Gaps = 2/99 (2%) Frame = +3 Query: 168 LGSGTFGTVYHGK--WRGTDVAIKRIKKSCFTGRSSEQERLAQEFWREAEILSKLHHPNV 341 LG G FG VY G G VA+K++K S ++ E ++L L HPN+ Sbjct: 15 LGKGAFGAVYRGLNIKNGETVAVKKVKLSKMLKSDLSVIKM------EIDLLKNLDHPNI 68 Query: 342 VAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQRKGQCPD 458 V + G + +L + E+ NGSLR + + G+ P+ Sbjct: 69 VKYRGSYQ--TNDSLCIILEYCENGSLRSICKNFGKIPE 105
>ERBB_ALV (P00534) Tyrosine-protein kinase transforming protein erbB (EC| 2.7.10.1) Length = 634 Score = 48.1 bits (113), Expect = 1e-05 Identities = 33/121 (27%), Positives = 58/121 (47%), Gaps = 2/121 (1%) Frame = +3 Query: 66 EDRTAAQVMDASLRDSDFEHLQIIKNEDLEELRELGSGTFGTVYHGKW--RGTDVAIKRI 239 ++R + + S + HL+I+K + ++++ LGSG FGTVY G W G V I Sbjct: 104 QERELVEPLTPSGEAPNQAHLRILKETEFKKVKVLGSGAFGTVYKGLWIPEGEKVKIPVA 163 Query: 240 KKSCFTGRSSEQERLAQEFWREAEILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGS 419 K R + + +E EA +++ + +P+V G+ T+ +T+ M G Sbjct: 164 IKEL---REATSPKANKEILDEAYVMASVDNPHVCRLLGICLT---STVQLITQLMPYGC 217 Query: 420 L 422 L Sbjct: 218 L 218
>YSK4_HUMAN (Q56UN5) SPS1/STE20-related protein kinase YSK4 (EC 2.7.11.1)| (Regulated in COPD, protein kinase) Length = 1328 Score = 48.1 bits (113), Expect = 1e-05 Identities = 32/100 (32%), Positives = 53/100 (53%), Gaps = 2/100 (2%) Frame = +3 Query: 168 LGSGTFGTVYHGKW-RGTDVAIKRIKKSCFTGRSSEQE-RLAQEFWREAEILSKLHHPNV 341 LG G +GTVY G +G +A+K++ ++E+E R QE E ++L L H N+ Sbjct: 1067 LGKGAYGTVYCGLTSQGQLIAVKQVALDTSNKLAAEKEYRKLQE---EVDLLKALKHVNI 1123 Query: 342 VAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQRKGQCPDL 461 VA+ G T++ EF+ GS+ ++ R G P++ Sbjct: 1124 VAYLGTCLQE--NTVSIFMEFVPGGSISSIINRFGPLPEM 1161
>CDS1_SCHPO (Q09170) Serine/threonine-protein kinase cds1 (EC 2.7.11.1)| (Checkpoint kinase cds1) Length = 460 Score = 48.1 bits (113), Expect = 1e-05 Identities = 39/109 (35%), Positives = 51/109 (46%), Gaps = 6/109 (5%) Frame = +3 Query: 138 KNEDLEELRELGSGTFGTVY------HGKWRGTDVAIKRIKKSCFTGRSSEQERLAQEFW 299 +N E +R LGSGTF V GKW AIK I K SSE+ R + F Sbjct: 163 ENSHYEIIRTLGSGTFAVVKLAVEVNSGKW----YAIKIINKRKILLTSSEK-RATEMFQ 217 Query: 300 REAEILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQRKG 446 RE +IL LHHP VV + + ++ L + E++ G L L G Sbjct: 218 REIDILKSLHHPGVVQCHEIFEN--DDELFIVMEYVEGGDLMDFLIANG 264
>WNK1_HUMAN (Q9H4A3) Serine/threonine-protein kinase WNK1 (EC 2.7.11.1)| (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1) (Kinase deficient protein) Length = 2382 Score = 47.8 bits (112), Expect = 2e-05 Identities = 33/94 (35%), Positives = 48/94 (51%), Gaps = 2/94 (2%) Frame = +3 Query: 165 ELGSGTFGTVYHGKWRGTDVAIKRIKKSCFTGRSSEQERLAQEFWREAEILSKLHHPNVV 344 E+G G+F TVY G T V + + SE++R F EAE+L L HPN+V Sbjct: 226 EIGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSERQR----FKEEAEMLKGLQHPNIV 281 Query: 345 AFYGVVKDGPGG--TLATLTEFMVNGSLRHVLQR 440 FY + G + +TE M +G+L+ L+R Sbjct: 282 RFYDSWESTVKGKKCIVLVTELMTSGTLKTYLKR 315
>CDC2_RAT (P39951) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 297 Score = 47.8 bits (112), Expect = 2e-05 Identities = 27/75 (36%), Positives = 43/75 (57%), Gaps = 2/75 (2%) Frame = +3 Query: 144 EDLEELRELGSGTFGTVYHGKWR--GTDVAIKRIKKSCFTGRSSEQERLAQEFWREAEIL 317 ED ++ ++G GT+G VY G+ R G VA+K+I+ SE+E + RE +L Sbjct: 2 EDYIKIEKIGEGTYGVVYKGRHRTTGQIVAMKKIR------LESEEEGVPSTAIREISLL 55 Query: 318 SKLHHPNVVAFYGVV 362 +L HPN+V+ V+ Sbjct: 56 KELRHPNIVSLQDVL 70
>CDC2_MOUSE (P11440) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 297 Score = 47.8 bits (112), Expect = 2e-05 Identities = 27/75 (36%), Positives = 43/75 (57%), Gaps = 2/75 (2%) Frame = +3 Query: 144 EDLEELRELGSGTFGTVYHGKWR--GTDVAIKRIKKSCFTGRSSEQERLAQEFWREAEIL 317 ED ++ ++G GT+G VY G+ R G VA+K+I+ SE+E + RE +L Sbjct: 2 EDYIKIEKIGEGTYGVVYKGRHRVTGQIVAMKKIR------LESEEEGVPSTAIREISLL 55 Query: 318 SKLHHPNVVAFYGVV 362 +L HPN+V+ V+ Sbjct: 56 KELRHPNIVSLQDVL 70
>XMRK_XIPMA (P13388) Melanoma receptor tyrosine-protein kinase precursor (EC| 2.7.10.1) Length = 1167 Score = 47.8 bits (112), Expect = 2e-05 Identities = 27/78 (34%), Positives = 42/78 (53%) Frame = +3 Query: 126 LQIIKNEDLEELRELGSGTFGTVYHGKWRGTDVAIKRIKKSCFTGRSSEQERLAQEFWRE 305 L+I+K + ++ R LGSG FGTVY G W I RI + R + ++ QE E Sbjct: 702 LRILKETEFKKDRVLGSGAFGTVYKGLWNPDGENI-RIPVAIKVLREATSPKVNQEVLDE 760 Query: 306 AEILSKLHHPNVVAFYGV 359 A +++ + HP+V G+ Sbjct: 761 AYVMASVDHPHVCRLLGI 778
>TNK1_MOUSE (Q99ML2) Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2)| (Kinase of embryonic stem cells) Length = 666 Score = 47.8 bits (112), Expect = 2e-05 Identities = 34/108 (31%), Positives = 48/108 (44%), Gaps = 5/108 (4%) Frame = +3 Query: 168 LGSGTFGTVYHGKW-----RGTDVAIKRIKKSCFTGRSSEQERLAQEFWREAEILSKLHH 332 LGSG FG V+ G W + VA+K ++ G +F RE ++ KL H Sbjct: 122 LGSGCFGVVHRGLWTLPSGQSIPVAVKSLR----VGPEGPMGTELGDFLREVSVMMKLEH 177 Query: 333 PNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQRKGQCPDLPQRLI 476 P+V+ +G+V P L + E GSL L P LP L+ Sbjct: 178 PHVLRLHGLVLGQP---LQMVMELAPLGSLHARLTAPAPTPPLPVALL 222
>PKND_CHLTR (O84303) Serine/threonine-protein kinase pknD (EC 2.7.11.1)| Length = 934 Score = 47.8 bits (112), Expect = 2e-05 Identities = 35/110 (31%), Positives = 53/110 (48%), Gaps = 4/110 (3%) Frame = +3 Query: 153 EELRELGSGTFGTVY--HGKWRGTDVAIKRIKKSCFTGRSSEQERLAQEFWREAEILSKL 326 E +R +G G G VY H K VA+KRI++ S L Q F REA+I + L Sbjct: 5 ELIRLIGKGGMGEVYLAHDKACSRRVALKRIREDL-----SGNALLRQRFLREAKIAADL 59 Query: 327 HHPNVVAFYGVVKDGPG--GTLATLTEFMVNGSLRHVLQRKGQCPDLPQR 470 HP +V Y + DG T+ + F + L+ V Q++ +L ++ Sbjct: 60 IHPGIVPVYSICSDGEAVYYTMPYIEGFSLKSLLKSVWQKEVLSKELEEK 109
>FES_MOUSE (P16879) Proto-oncogene tyrosine-protein kinase Fes/Fps (EC| 2.7.10.2) (C-Fes) Length = 820 Score = 47.8 bits (112), Expect = 2e-05 Identities = 30/78 (38%), Positives = 44/78 (56%), Gaps = 2/78 (2%) Frame = +3 Query: 132 IIKNEDLEELRELGSGTFGTVYHGKWRG--TDVAIKRIKKSCFTGRSSEQERLAQEFWRE 305 ++K+EDL ++G G FG V+ G+ R T VA+K SC R + L +F +E Sbjct: 553 VLKHEDLVLGEQIGRGNFGEVFSGRLRADNTPVAVK----SC---RETLPPDLKAKFLQE 605 Query: 306 AEILSKLHHPNVVAFYGV 359 A IL + +HPN+V GV Sbjct: 606 ARILKQYNHPNIVRLIGV 623
>KPCD3_HUMAN (O94806) Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein| kinase C nu type) (nPKC-nu) (Protein kinase EPK2) Length = 890 Score = 47.8 bits (112), Expect = 2e-05 Identities = 34/80 (42%), Positives = 40/80 (50%), Gaps = 8/80 (10%) Frame = +3 Query: 129 QIIKNEDLEELRE------LGSGTFGTVYHGKWR--GTDVAIKRIKKSCFTGRSSEQERL 284 QI +N D+ + + LGSG FG VY GK R G DVAIK I K F + Q R Sbjct: 563 QIQENVDISTVYQIFADEVLGSGQFGIVYGGKHRKTGRDVAIKVIDKMRFPTKQESQLR- 621 Query: 285 AQEFWREAEILSKLHHPNVV 344 E IL LHHP +V Sbjct: 622 -----NEVAILQNLHHPGIV 636
>KPCD1_MOUSE (Q62101) Serine/threonine-protein kinase D1 (EC 2.7.11.13)| (nPKC-D1) (Protein kinase D) (Protein kinase C mu type) (nPKC-mu) Length = 918 Score = 47.8 bits (112), Expect = 2e-05 Identities = 35/80 (43%), Positives = 40/80 (50%), Gaps = 8/80 (10%) Frame = +3 Query: 129 QIIKNEDLEELRE------LGSGTFGTVYHGKWR--GTDVAIKRIKKSCFTGRSSEQERL 284 QI +N D+ + + LGSG FG VY GK R G DVAIK I K F + Q R Sbjct: 576 QIQENVDISTVYQIFPDEVLGSGQFGIVYGGKHRKTGRDVAIKIIDKLRFPTKQESQLR- 634 Query: 285 AQEFWREAEILSKLHHPNVV 344 E IL LHHP VV Sbjct: 635 -----NEVAILQNLHHPGVV 649
>WNK1_RAT (Q9JIH7) Serine/threonine-protein kinase WNK1 (EC 2.7.11.1)| (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1) Length = 2126 Score = 47.8 bits (112), Expect = 2e-05 Identities = 33/94 (35%), Positives = 48/94 (51%), Gaps = 2/94 (2%) Frame = +3 Query: 165 ELGSGTFGTVYHGKWRGTDVAIKRIKKSCFTGRSSEQERLAQEFWREAEILSKLHHPNVV 344 E+G G+F TVY G T V + + SE++R F EAE+L L HPN+V Sbjct: 226 EIGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSERQR----FKEEAEMLKGLQHPNIV 281 Query: 345 AFYGVVKDGPGG--TLATLTEFMVNGSLRHVLQR 440 FY + G + +TE M +G+L+ L+R Sbjct: 282 RFYDSWESTVKGKKCIVLVTELMTSGTLKTYLKR 315
>TMK1_ARATH (P43298) Putative receptor protein kinase TMK1 precursor (EC| 2.7.11.1) Length = 942 Score = 47.8 bits (112), Expect = 2e-05 Identities = 39/110 (35%), Positives = 57/110 (51%), Gaps = 5/110 (4%) Frame = +3 Query: 168 LGSGTFGTVYHGKWR-GTDVAIKRIKKSCFTGRSSEQERLAQEFWREAEILSKLHHPNVV 344 LGSG FG VY G+ GT +A+KR++ G+ EF E +L+K+ H ++V Sbjct: 594 LGSGGFGVVYKGELHDGTKIAVKRMENGVIAGKG------FAEFKSEIAVLTKVRHRHLV 647 Query: 345 AFYGVVKDGPGGTLATLTEFMVNGSL-RHVLQ--RKGQCPDL-PQRLIIA 482 G DG L + E+M G+L RH+ + +G P L QRL +A Sbjct: 648 TLLGYCLDGNEKLL--VYEYMPQGTLSRHLFEWSEEGLKPLLWKQRLTLA 695
>KPCD3_MOUSE (Q8K1Y2) Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein| kinase C nu type) (nPKC-nu) Length = 889 Score = 47.8 bits (112), Expect = 2e-05 Identities = 33/80 (41%), Positives = 40/80 (50%), Gaps = 8/80 (10%) Frame = +3 Query: 129 QIIKNEDLEELRE------LGSGTFGTVYHGKWR--GTDVAIKRIKKSCFTGRSSEQERL 284 Q+ +N D+ + + LGSG FG VY GK R G DVAIK I K F + Q R Sbjct: 562 QVQENVDISSVYQIFADEVLGSGQFGIVYGGKHRKTGRDVAIKVIDKMRFPTKQESQLR- 620 Query: 285 AQEFWREAEILSKLHHPNVV 344 E IL LHHP +V Sbjct: 621 -----NEVAILQNLHHPGIV 635
>E2AK2_SCHPO (Q9UTE5) Eukaryotic translation initiation factor 2-alpha kinase 2| (EC 2.7.11.1) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor 2) Length = 639 Score = 47.8 bits (112), Expect = 2e-05 Identities = 27/72 (37%), Positives = 41/72 (56%), Gaps = 2/72 (2%) Frame = +3 Query: 144 EDLEELRELGSGTFGTVYH--GKWRGTDVAIKRIKKSCFTGRSSEQERLAQEFWREAEIL 317 ED EE LG G FG+VYH K G + A+K+I S+ Q+ + +RE + L Sbjct: 169 EDFEEYSLLGRGGFGSVYHVRNKIDGAEYAMKKI-------NSTFQQMSYSKIFREIKCL 221 Query: 318 SKLHHPNVVAFY 353 +K+ HPNV+ ++ Sbjct: 222 AKMDHPNVIRYF 233
>KPCD1_HUMAN (Q15139) Serine/threonine-protein kinase D1 (EC 2.7.11.13)| (nPKC-D1) (Protein kinase D) (Protein kinase C mu type) (nPKC-mu) Length = 912 Score = 47.8 bits (112), Expect = 2e-05 Identities = 35/80 (43%), Positives = 40/80 (50%), Gaps = 8/80 (10%) Frame = +3 Query: 129 QIIKNEDLEELRE------LGSGTFGTVYHGKWR--GTDVAIKRIKKSCFTGRSSEQERL 284 QI +N D+ + + LGSG FG VY GK R G DVAIK I K F + Q R Sbjct: 570 QIQENVDISTVYQIFPDEVLGSGQFGIVYGGKHRKTGRDVAIKIIDKLRFPTKQESQLR- 628 Query: 285 AQEFWREAEILSKLHHPNVV 344 E IL LHHP VV Sbjct: 629 -----NEVAILQNLHHPGVV 643
>RIPK2_HUMAN (O43353) Receptor-interacting serine/threonine-protein kinase 2 (EC| 2.7.11.1) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (CARD-containing interleukin-1 beta-converting enzyme-associated kinase) (CARD-containi Length = 540 Score = 47.8 bits (112), Expect = 2e-05 Identities = 36/108 (33%), Positives = 50/108 (46%) Frame = +3 Query: 138 KNEDLEELRELGSGTFGTVYHGKWRGTDVAIKRIKKSCFTGRSSEQERLAQEFWREAEIL 317 K DL L SGT + H WR VA+K + S ++ L REAEIL Sbjct: 17 KLADLRYLSRGASGTVSSARHADWR-VQVAVKHLHIHTPLLDSERKDVL-----REAEIL 70 Query: 318 SKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQRKGQCPDL 461 K ++ G+ + L +TE+M NGSL +L RK + PD+ Sbjct: 71 HKARFSYILPILGICNEPE--FLGIVTEYMPNGSLNELLHRKTEYPDV 116
>ERBB_AVIER (P00535) Tyrosine-protein kinase transforming protein erbB (EC| 2.7.10.1) Length = 604 Score = 47.8 bits (112), Expect = 2e-05 Identities = 32/121 (26%), Positives = 58/121 (47%), Gaps = 2/121 (1%) Frame = +3 Query: 66 EDRTAAQVMDASLRDSDFEHLQIIKNEDLEELRELGSGTFGTVYHGKW--RGTDVAIKRI 239 ++R + + S + HL+I+K + ++++ LGSG FGT+Y G W G V I Sbjct: 104 QERELVEPLTPSGEAPNQAHLRILKETEFKKVKVLGSGAFGTIYKGLWIPEGEKVKIPVA 163 Query: 240 KKSCFTGRSSEQERLAQEFWREAEILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGS 419 K R + + +E EA +++ + +P+V G+ T+ +T+ M G Sbjct: 164 IKEL---REATSPKANKEILDEAYVMASVDNPHVCRLLGICLT---STVQLITQLMPYGC 217 Query: 420 L 422 L Sbjct: 218 L 218
>CDC2_HUMAN (P06493) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 297 Score = 47.4 bits (111), Expect = 2e-05 Identities = 27/75 (36%), Positives = 42/75 (56%), Gaps = 2/75 (2%) Frame = +3 Query: 144 EDLEELRELGSGTFGTVYHG--KWRGTDVAIKRIKKSCFTGRSSEQERLAQEFWREAEIL 317 ED ++ ++G GT+G VY G K G VA+K+I+ SE+E + RE +L Sbjct: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIR------LESEEEGVPSTAIREISLL 55 Query: 318 SKLHHPNVVAFYGVV 362 +L HPN+V+ V+ Sbjct: 56 KELRHPNIVSLQDVL 70
>CDC2_BOVIN (P48734) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 297 Score = 47.4 bits (111), Expect = 2e-05 Identities = 27/75 (36%), Positives = 42/75 (56%), Gaps = 2/75 (2%) Frame = +3 Query: 144 EDLEELRELGSGTFGTVYHG--KWRGTDVAIKRIKKSCFTGRSSEQERLAQEFWREAEIL 317 ED ++ ++G GT+G VY G K G VA+K+I+ SE+E + RE +L Sbjct: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIR------LESEEEGVPSTAIREISLL 55 Query: 318 SKLHHPNVVAFYGVV 362 +L HPN+V+ V+ Sbjct: 56 KELRHPNIVSLQDVL 70
>MOS_HUMAN (P00540) Proto-oncogene serine/threonine-protein kinase mos (EC| 2.7.11.1) (c-mos) (Oocyte maturation factor mos) Length = 346 Score = 47.4 bits (111), Expect = 2e-05 Identities = 33/95 (34%), Positives = 50/95 (52%), Gaps = 3/95 (3%) Frame = +3 Query: 159 LRELGSGTFGTVYHGKWRGTDVAIKRIKKSCFTGRSSEQERLAQEFWREAEILSKLHHPN 338 L+ LG+G FG+VY +RG VAIK++ K C R + + + FW E + ++L H N Sbjct: 63 LQRLGAGGFGSVYKATYRGVPVAIKQVNK-CTKNRLASR----RSFWAELNV-ARLRHDN 116 Query: 339 VVAFYGVVKDGPGG--TLAT-LTEFMVNGSLRHVL 434 +V P G +L T + EF N +L V+ Sbjct: 117 IVRVVAASTRTPAGSNSLGTIIMEFGGNVTLHQVI 151
>M3K1_MOUSE (P53349) Mitogen-activated protein kinase kinase kinase 1 (EC| 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1) Length = 1493 Score = 47.4 bits (111), Expect = 2e-05 Identities = 29/103 (28%), Positives = 49/103 (47%), Gaps = 2/103 (1%) Frame = +3 Query: 144 EDLEELR--ELGSGTFGTVYHGKWRGTDVAIKRIKKSCFTGRSSEQERLAQEFWREAEIL 317 ED E L+ ++G G F + Y + GT + + + SSEQE + + E ++ Sbjct: 1220 EDAEWLKGQQIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMM 1279 Query: 318 SKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQRKG 446 L+HPN++ G + L E+M GS+ H+L + G Sbjct: 1280 GHLNHPNIIRMLGATCEKSNYNL--FIEWMAGGSVAHLLSKYG 1320
>TAOK2_MOUSE (Q6ZQ29) Serine/threonine-protein kinase TAO2 (EC 2.7.11.1)| (Thousand and one amino acid protein 2) Length = 1055 Score = 47.4 bits (111), Expect = 2e-05 Identities = 30/89 (33%), Positives = 48/89 (53%), Gaps = 3/89 (3%) Frame = +3 Query: 99 SLRDSDFEHLQIIKNED--LEELRELGSGTFGTVYHGK-WRGTDVAIKRIKKSCFTGRSS 269 SL+D D L + + +LRE+G G+FG VY + R ++V IKK ++G+ S Sbjct: 9 SLKDPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVA--IKKMSYSGKQS 66 Query: 270 EQERLAQEFWREAEILSKLHHPNVVAFYG 356 ++ Q+ +E L KL HPN + + G Sbjct: 67 NEKW--QDIIKEVRFLQKLRHPNTIQYRG 93
>PBS1_ARATH (Q9FE20) Serine/threonine-protein kinase PBS1 (EC 2.7.11.1)| (AvrPphB susceptible protein 1) Length = 456 Score = 47.4 bits (111), Expect = 2e-05 Identities = 40/110 (36%), Positives = 52/110 (47%), Gaps = 5/110 (4%) Frame = +3 Query: 168 LGSGTFGTVYHGKWRGTD--VAIKRIKKSCFTGRSSEQERLAQEFWREAEILSKLHHPNV 341 LG G FG VY G+ T VA+K++ ++ G +EF E +LS LHHPN+ Sbjct: 92 LGEGGFGRVYKGRLDSTGQVVAVKQLDRNGLQGN--------REFLVEVLMLSLLHHPNL 143 Query: 342 VAFYGVVKDGPGGTLATLTEFMVNGSLR---HVLQRKGQCPDLPQRLIIA 482 V G DG L + EFM GSL H L + D R+ IA Sbjct: 144 VNLIGYCADGDQRLL--VYEFMPLGSLEDHLHDLPPDKEALDWNMRMKIA 191
>CDC2_ORYLU (Q9DG98) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 303 Score = 47.4 bits (111), Expect = 2e-05 Identities = 27/75 (36%), Positives = 42/75 (56%), Gaps = 2/75 (2%) Frame = +3 Query: 144 EDLEELRELGSGTFGTVYHGKWRGTD--VAIKRIKKSCFTGRSSEQERLAQEFWREAEIL 317 ED ++ ++G GT+G VY G+ + T VA+K+I+ SE+E + RE +L Sbjct: 2 EDYVKIEKIGEGTYGVVYKGRHKSTGQVVAMKKIR------LESEEEGVPSTAVREVSLL 55 Query: 318 SKLHHPNVVAFYGVV 362 +L HPNVV V+ Sbjct: 56 QELKHPNVVRLLDVL 70
>CDC2_ORYLA (Q9DGD3) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 303 Score = 47.4 bits (111), Expect = 2e-05 Identities = 27/75 (36%), Positives = 42/75 (56%), Gaps = 2/75 (2%) Frame = +3 Query: 144 EDLEELRELGSGTFGTVYHGKWRGTD--VAIKRIKKSCFTGRSSEQERLAQEFWREAEIL 317 ED ++ ++G GT+G VY G+ + T VA+K+I+ SE+E + RE +L Sbjct: 2 EDYVKIEKIGEGTYGVVYKGRHKSTGQVVAMKKIR------LESEEEGVPSTAVREVSLL 55 Query: 318 SKLHHPNVVAFYGVV 362 +L HPNVV V+ Sbjct: 56 QELKHPNVVRLLDVL 70
>CDC2_ORYJA (Q9DGA2) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 303 Score = 47.4 bits (111), Expect = 2e-05 Identities = 27/75 (36%), Positives = 42/75 (56%), Gaps = 2/75 (2%) Frame = +3 Query: 144 EDLEELRELGSGTFGTVYHGKWRGTD--VAIKRIKKSCFTGRSSEQERLAQEFWREAEIL 317 ED ++ ++G GT+G VY G+ + T VA+K+I+ SE+E + RE +L Sbjct: 2 EDYVKIEKIGEGTYGVVYKGRHKSTGQVVAMKKIR------LESEEEGVPSTAVREVSLL 55 Query: 318 SKLHHPNVVAFYGVV 362 +L HPNVV V+ Sbjct: 56 QELKHPNVVRLLDVL 70
>CDC2_ORYCU (Q9DGA5) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 303 Score = 47.4 bits (111), Expect = 2e-05 Identities = 27/75 (36%), Positives = 42/75 (56%), Gaps = 2/75 (2%) Frame = +3 Query: 144 EDLEELRELGSGTFGTVYHGKWRGTD--VAIKRIKKSCFTGRSSEQERLAQEFWREAEIL 317 ED ++ ++G GT+G VY G+ + T VA+K+I+ SE+E + RE +L Sbjct: 2 EDYVKIEKIGEGTYGVVYKGRHKSTGQVVAMKKIR------LESEEEGVPSTAVREVSLL 55 Query: 318 SKLHHPNVVAFYGVV 362 +L HPNVV V+ Sbjct: 56 QELKHPNVVRLLDVL 70
>M3K2_HUMAN (Q9Y2U5) Mitogen-activated protein kinase kinase kinase 2 (EC| 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2) Length = 619 Score = 47.4 bits (111), Expect = 2e-05 Identities = 29/95 (30%), Positives = 48/95 (50%), Gaps = 2/95 (2%) Frame = +3 Query: 168 LGSGTFGTVY--HGKWRGTDVAIKRIKKSCFTGRSSEQERLAQEFWREAEILSKLHHPNV 341 LG G FG VY + G ++A+K+++ F S E + E ++L L H + Sbjct: 362 LGQGAFGRVYLCYDVDTGRELAVKQVQ---FDPDSPETSKEVNALECEIQLLKNLLHERI 418 Query: 342 VAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQRKG 446 V +YG ++D TL+ E+M GS++ L+ G Sbjct: 419 VQYYGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYG 453
>INSRR_HUMAN (P14616) Insulin receptor-related protein precursor (EC 2.7.10.1)| (IRR) (IR-related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain] Length = 1297 Score = 47.4 bits (111), Expect = 2e-05 Identities = 34/115 (29%), Positives = 50/115 (43%), Gaps = 4/115 (3%) Frame = +3 Query: 135 IKNEDLEELRELGSGTFGTVYHGKWRGTDVAIKRIKKSCFTGRSSEQERLAQEFWREAEI 314 + E + +RELG G+FG VY G RG + + + T R EF +EA + Sbjct: 974 VPREQISIIRELGQGSFGMVYEGLARGLEAGEESTPVALKTVNELASPRECIEFLKEASV 1033 Query: 315 LSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLR-HVLQRKGQC---PDLPQ 467 + +VV GVV G + E M G L+ H+ + + P LPQ Sbjct: 1034 MKAFKCHHVVRLLGVVSQGQ--PTLVIMELMTRGDLKSHLRSLRPEAENNPGLPQ 1086
>EPHA8_HUMAN (P29322) Ephrin type-A receptor 8 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) (HEK3) Length = 1005 Score = 47.4 bits (111), Expect = 2e-05 Identities = 43/138 (31%), Positives = 62/138 (44%), Gaps = 7/138 (5%) Frame = +3 Query: 30 LPAPDF--EEPKFEEDRTAAQVMDASLRDSDFEHLQIIKNEDLEELRELGSGTFGTVYHG 203 LP P F E +EE A + + S H++ I +GSG G V +G Sbjct: 604 LPEPQFYAEPHTYEEPGRAGRSFTREIEASRI-HIEKI----------IGSGDSGEVCYG 652 Query: 204 KWR-----GTDVAIKRIKKSCFTGRSSEQERLAQEFWREAEILSKLHHPNVVAFYGVVKD 368 + R VAIK +K + ER ++F EA I+ + HPN++ GVV Sbjct: 653 RLRVPGQRDVPVAIKALK-------AGYTERQRRDFLSEASIMGQFDHPNIIRLEGVVTR 705 Query: 369 GPGGTLATLTEFMVNGSL 422 G + +TE+M NGSL Sbjct: 706 GRLAMI--VTEYMENGSL 721
>EPHA8_MOUSE (O09127) Ephrin type-A receptor 8 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) Length = 1004 Score = 47.4 bits (111), Expect = 2e-05 Identities = 33/90 (36%), Positives = 46/90 (51%), Gaps = 5/90 (5%) Frame = +3 Query: 168 LGSGTFGTVYHGKW-----RGTDVAIKRIKKSCFTGRSSEQERLAQEFWREAEILSKLHH 332 +GSG G V +G+ R VAIK +K + ER Q+F EA I+ + H Sbjct: 640 IGSGESGEVCYGRLQVPGQRDVPVAIKALK-------AGYTERQRQDFLSEAAIMGQFDH 692 Query: 333 PNVVAFYGVVKDGPGGTLATLTEFMVNGSL 422 PN++ GVV G + +TE+M NGSL Sbjct: 693 PNIIRLEGVVTRGRLAMI--VTEYMENGSL 720
>ABL2_HUMAN (P42684) Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine| leukemia viral oncogene homolog 2) (Tyrosine kinase ARG) Length = 1182 Score = 47.4 bits (111), Expect = 2e-05 Identities = 31/103 (30%), Positives = 50/103 (48%), Gaps = 2/103 (1%) Frame = +3 Query: 135 IKNEDLEELRELGSGTFGTVYHGKWR--GTDVAIKRIKKSCFTGRSSEQERLAQEFWREA 308 ++ D+ +LG G +G VY G W+ VA+K +K E +EF +EA Sbjct: 283 MERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLK---------EDTMEVEEFLKEA 333 Query: 309 EILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQ 437 ++ ++ HPN+V GV P +TE+M G+L L+ Sbjct: 334 AVMKEIKHPNLVQLLGVCTLEP--PFYIVTEYMPYGNLLDYLR 374
>TAOK2_RAT (Q9JLS3) Serine/threonine-protein kinase TAO2 (EC 2.7.11.1)| (Thousand and one amino acid protein 2) Length = 1235 Score = 47.4 bits (111), Expect = 2e-05 Identities = 30/89 (33%), Positives = 48/89 (53%), Gaps = 3/89 (3%) Frame = +3 Query: 99 SLRDSDFEHLQIIKNED--LEELRELGSGTFGTVYHGK-WRGTDVAIKRIKKSCFTGRSS 269 SL+D D L + + +LRE+G G+FG VY + R ++V IKK ++G+ S Sbjct: 9 SLKDPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVA--IKKMSYSGKQS 66 Query: 270 EQERLAQEFWREAEILSKLHHPNVVAFYG 356 ++ Q+ +E L KL HPN + + G Sbjct: 67 NEKW--QDIIKEVRFLQKLRHPNTIQYRG 93
>TAOK2_HUMAN (Q9UL54) Serine/threonine-protein kinase TAO2 (EC 2.7.11.1)| (Thousand and one amino acid protein 2) (Prostate-derived STE20-like kinase 1) (PSK-1) (Kinase from chicken homolog C) (hKFC-C) Length = 1235 Score = 47.4 bits (111), Expect = 2e-05 Identities = 30/89 (33%), Positives = 48/89 (53%), Gaps = 3/89 (3%) Frame = +3 Query: 99 SLRDSDFEHLQIIKNED--LEELRELGSGTFGTVYHGK-WRGTDVAIKRIKKSCFTGRSS 269 SL+D D L + + +LRE+G G+FG VY + R ++V IKK ++G+ S Sbjct: 9 SLKDPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVA--IKKMSYSGKQS 66 Query: 270 EQERLAQEFWREAEILSKLHHPNVVAFYG 356 ++ Q+ +E L KL HPN + + G Sbjct: 67 NEKW--QDIIKEVRFLQKLRHPNTIQYRG 93
>INSRR_MOUSE (Q9WTL4) Insulin receptor-related protein precursor (EC 2.7.10.1)| (IRR) (IR-related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain] Length = 1300 Score = 47.4 bits (111), Expect = 2e-05 Identities = 39/122 (31%), Positives = 58/122 (47%), Gaps = 11/122 (9%) Frame = +3 Query: 135 IKNEDLEELRELGSGTFGTVYHGKWRG-------TDVAIKRIKKSCFTGRSSEQERLAQE 293 + E + +RELG G+FG VY G RG T VA+K + + +S +ER+ E Sbjct: 974 VPREQIAIIRELGQGSFGMVYEGLARGLEAGEESTPVALKTVNE-----LASARERV--E 1026 Query: 294 FWREAEILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLR-HVLQRKGQC---PDL 461 F +EA ++ +VV GVV G + E M G L+ H+ + + P L Sbjct: 1027 FLKEASVMKAFKCHHVVRLLGVVSQGQ--PTLVIMELMTRGDLKSHLRSLRPEAENNPGL 1084 Query: 462 PQ 467 PQ Sbjct: 1085 PQ 1086
>EXS_ARATH (Q9LYN8) Leucine-rich repeat receptor protein kinase EXS precursor| (EC 2.7.11.1) (Extra sporogenous cells protein) (EXCESS MICROSPOROCYTES1 protein) Length = 1192 Score = 47.4 bits (111), Expect = 2e-05 Identities = 33/93 (35%), Positives = 47/93 (50%), Gaps = 1/93 (1%) Frame = +3 Query: 168 LGSGTFGTVYHGKWRGTD-VAIKRIKKSCFTGRSSEQERLAQEFWREAEILSKLHHPNVV 344 +G G FGTVY G VA+K++ ++ G +EF E E L K+ HPN+V Sbjct: 923 IGDGGFGTVYKACLPGEKTVAVKKLSEAKTQGN--------REFMAEMETLGKVKHPNLV 974 Query: 345 AFYGVVKDGPGGTLATLTEFMVNGSLRHVLQRK 443 + G L + E+MVNGSL H L+ + Sbjct: 975 SLLGYCSFSEEKLL--VYEYMVNGSLDHWLRNQ 1005
>RIPK2_MOUSE (P58801) Receptor-interacting serine/threonine-protein kinase 2 (EC| 2.7.11.1) Length = 539 Score = 47.0 bits (110), Expect = 3e-05 Identities = 36/108 (33%), Positives = 49/108 (45%) Frame = +3 Query: 138 KNEDLEELRELGSGTFGTVYHGKWRGTDVAIKRIKKSCFTGRSSEQERLAQEFWREAEIL 317 K DL L SGT + H WR VA+K + S + L REAEIL Sbjct: 17 KLADLHYLSRGASGTVSSARHADWR-VRVAVKHLHIHTPLLDSERNDIL-----REAEIL 70 Query: 318 SKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQRKGQCPDL 461 K ++ G+ + L +TE+M NGSL +L RK + PD+ Sbjct: 71 HKARFSYILPILGICNEPE--FLGIVTEYMPNGSLNELLHRKTEYPDI 116
>CDPK1_PLAYO (Q7RAH3) Calcium-dependent protein kinase 1 (EC 2.7.11.1)| Length = 534 Score = 47.0 bits (110), Expect = 3e-05 Identities = 35/100 (35%), Positives = 53/100 (53%), Gaps = 7/100 (7%) Frame = +3 Query: 144 EDLEELRELGSGTFGTVYHGKWRG--TDVAIKRIKKSCFT-GRSSEQ----ERLAQEFWR 302 E ++R+LGSG +G V K + ++ AIK IKKS F GR ++ E+ +E + Sbjct: 54 ESYFKVRKLGSGAYGEVLLCKEKNGHSEKAIKVIKKSQFDKGRYNDDNKNIEKFHEEIYN 113 Query: 303 EAEILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSL 422 E +L L HPN++ + V +D L +TEF G L Sbjct: 114 EISLLKSLDHPNIIKLFDVFEDKKYFYL--VTEFYEGGEL 151
>EPHB2_COTJA (Q90344) Ephrin type-B receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor QEK5) Length = 987 Score = 47.0 bits (110), Expect = 3e-05 Identities = 39/101 (38%), Positives = 50/101 (49%), Gaps = 7/101 (6%) Frame = +3 Query: 168 LGSGTFGTVYHGKW-----RGTDVAIKRIKKSCFTGRSSEQERLAQEFWREAEILSKLHH 332 +G+G FG V G R VAIK +K S E+ ++F EA I+ + H Sbjct: 628 IGAGEFGEVCSGHLKLPGKREIFVAIKTLK-------SGYTEKQRRDFLSEASIMGQFDH 680 Query: 333 PNVVAFYGVV-KDGPGGTLATLTEFMVNGSLRHVL-QRKGQ 449 PNV+ GVV K P + +TEFM NGSL L Q GQ Sbjct: 681 PNVIHLEGVVTKSSP---VMIITEFMENGSLDSFLRQNDGQ 718
>IGF1R_RAT (P24062) Insulin-like growth factor 1 receptor precursor (EC| 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain] Length = 1370 Score = 47.0 bits (110), Expect = 3e-05 Identities = 37/122 (30%), Positives = 59/122 (48%), Gaps = 7/122 (5%) Frame = +3 Query: 135 IKNEDLEELRELGSGTFGTVYHGKWRG-------TDVAIKRIKKSCFTGRSSEQERLAQE 293 + E + RELG G+FG VY G +G T VAIK + ++ +S +ER+ E Sbjct: 995 VAREKITMNRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEA-----ASMRERI--E 1047 Query: 294 FWREAEILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQRKGQCPDLPQRL 473 F EA ++ + + +VV GVV G + E M G L+ L + P++ L Sbjct: 1048 FLNEASVMKEFNCHHVVRLLGVVSQGQ--PTLVIMELMTRGDLKSYL--RSLRPEVENNL 1103 Query: 474 II 479 ++ Sbjct: 1104 VL 1105
>IGF1R_BOVIN (Q05688) Insulin-like growth factor 1 receptor precursor (EC| 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain] (F Length = 640 Score = 47.0 bits (110), Expect = 3e-05 Identities = 35/108 (32%), Positives = 53/108 (49%), Gaps = 7/108 (6%) Frame = +3 Query: 135 IKNEDLEELRELGSGTFGTVYHGKWRG-------TDVAIKRIKKSCFTGRSSEQERLAQE 293 + E + RELG G+FG VY G +G T VAIK + ++ +S +ER+ E Sbjct: 267 VAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEA-----ASMRERI--E 319 Query: 294 FWREAEILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQ 437 F EA ++ + + +VV GVV G + E M G L+ L+ Sbjct: 320 FLNEASVMKEFNCHHVVRLLGVVSQGQ--PTLVIMELMTRGDLKSYLR 365
>IGF1R_HUMAN (P08069) Insulin-like growth factor 1 receptor precursor (EC| 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 recepto Length = 1367 Score = 47.0 bits (110), Expect = 3e-05 Identities = 35/108 (32%), Positives = 53/108 (49%), Gaps = 7/108 (6%) Frame = +3 Query: 135 IKNEDLEELRELGSGTFGTVYHGKWRG-------TDVAIKRIKKSCFTGRSSEQERLAQE 293 + E + RELG G+FG VY G +G T VAIK + ++ +S +ER+ E Sbjct: 994 VAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEA-----ASMRERI--E 1046 Query: 294 FWREAEILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQ 437 F EA ++ + + +VV GVV G + E M G L+ L+ Sbjct: 1047 FLNEASVMKEFNCHHVVRLLGVVSQGQ--PTLVIMELMTRGDLKSYLR 1092
>EPHB2_CHICK (P28693) Ephrin type-B receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor CEK5) Length = 1004 Score = 47.0 bits (110), Expect = 3e-05 Identities = 39/101 (38%), Positives = 50/101 (49%), Gaps = 7/101 (6%) Frame = +3 Query: 168 LGSGTFGTVYHGKW-----RGTDVAIKRIKKSCFTGRSSEQERLAQEFWREAEILSKLHH 332 +G+G FG V G R VAIK +K S E+ ++F EA I+ + H Sbjct: 645 IGAGEFGEVCSGHLKLPGKREIFVAIKTLK-------SGYTEKQRRDFLSEASIMGQFDH 697 Query: 333 PNVVAFYGVV-KDGPGGTLATLTEFMVNGSLRHVL-QRKGQ 449 PNV+ GVV K P + +TEFM NGSL L Q GQ Sbjct: 698 PNVIHLEGVVTKSSP---VMIITEFMENGSLDSFLRQNDGQ 735
>ACV1B_RAT (P80202) Activin receptor type 1B precursor (EC 2.7.11.30)| (ACTR-IB) (Serine/threonine-protein kinase receptor R2) (SKR2) Length = 505 Score = 47.0 bits (110), Expect = 3e-05 Identities = 46/147 (31%), Positives = 68/147 (46%), Gaps = 14/147 (9%) Frame = +3 Query: 42 DFEEPKFE----EDRTAAQ-VMDASLRDSD-----FEHLQIIKNEDLEELRELGSGTFGT 191 D E+P E +D+T V D S S F + + L+E+ +G G FG Sbjct: 163 DMEDPSCEMCLSKDKTLQDLVYDLSTSGSGSGLPLFVQRTVARTIVLQEI--IGKGRFGE 220 Query: 192 VYHGKWRGTDVAIKRIKKSCFTGRSSEQERLAQEFWREAEILS--KLHHPNVVAFYGV-- 359 V+ G+WRG DVA+K SS +ER ++REAEI L H N++ F Sbjct: 221 VWRGRWRGGDVAVKIF--------SSREER---SWFREAEIYQTVMLRHENILGFIAADN 269 Query: 360 VKDGPGGTLATLTEFMVNGSLRHVLQR 440 +G L ++++ +GSL L R Sbjct: 270 KDNGTWTQLWLVSDYHEHGSLFDYLNR 296
>ACV1B_MOUSE (Q61271) Activin receptor type 1B precursor (EC 2.7.11.30)| (ACTR-IB) (Serine/threonine-protein kinase receptor R2) (SKR2) Length = 505 Score = 47.0 bits (110), Expect = 3e-05 Identities = 46/147 (31%), Positives = 68/147 (46%), Gaps = 14/147 (9%) Frame = +3 Query: 42 DFEEPKFE----EDRTAAQ-VMDASLRDSD-----FEHLQIIKNEDLEELRELGSGTFGT 191 D E+P E +D+T V D S S F + + L+E+ +G G FG Sbjct: 163 DMEDPSCEMCLSKDKTLQDLVYDLSTSGSGSGLPLFVQRTVARTIVLQEI--IGKGRFGE 220 Query: 192 VYHGKWRGTDVAIKRIKKSCFTGRSSEQERLAQEFWREAEILS--KLHHPNVVAFYGV-- 359 V+ G+WRG DVA+K SS +ER ++REAEI L H N++ F Sbjct: 221 VWRGRWRGGDVAVKIF--------SSREER---SWFREAEIYQTVMLRHENILGFIAADN 269 Query: 360 VKDGPGGTLATLTEFMVNGSLRHVLQR 440 +G L ++++ +GSL L R Sbjct: 270 KDNGTWTQLWLVSDYHEHGSLFDYLNR 296
>ACV1B_HUMAN (P36896) Activin receptor type 1B precursor (EC 2.7.11.30)| (ACTR-IB) (Serine/threonine-protein kinase receptor R2) (SKR2) (Activin receptor-like kinase 4) (ALK-4) Length = 505 Score = 47.0 bits (110), Expect = 3e-05 Identities = 46/147 (31%), Positives = 68/147 (46%), Gaps = 14/147 (9%) Frame = +3 Query: 42 DFEEPKFE----EDRTAAQ-VMDASLRDSD-----FEHLQIIKNEDLEELRELGSGTFGT 191 D E+P E +D+T V D S S F + + L+E+ +G G FG Sbjct: 163 DMEDPSCEMCLSKDKTLQDLVYDLSTSGSGSGLPLFVQRTVARTIVLQEI--IGKGRFGE 220 Query: 192 VYHGKWRGTDVAIKRIKKSCFTGRSSEQERLAQEFWREAEILS--KLHHPNVVAFYGV-- 359 V+ G+WRG DVA+K SS +ER ++REAEI L H N++ F Sbjct: 221 VWRGRWRGGDVAVKIF--------SSREER---SWFREAEIYQTVMLRHENILGFIAADN 269 Query: 360 VKDGPGGTLATLTEFMVNGSLRHVLQR 440 +G L ++++ +GSL L R Sbjct: 270 KDNGTWTQLWLVSDYHEHGSLFDYLNR 296
>M3K1_RAT (Q62925) Mitogen-activated protein kinase kinase kinase 1 (EC| 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1) Length = 1493 Score = 46.6 bits (109), Expect = 3e-05 Identities = 29/103 (28%), Positives = 49/103 (47%), Gaps = 2/103 (1%) Frame = +3 Query: 144 EDLEELR--ELGSGTFGTVYHGKWRGTDVAIKRIKKSCFTGRSSEQERLAQEFWREAEIL 317 ED E L+ ++G G F + Y + GT + + + SSEQE + + E ++ Sbjct: 1220 EDTEWLKGQQIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMM 1279 Query: 318 SKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQRKG 446 S L+HPN++ G + L E+M S+ H+L + G Sbjct: 1280 SHLNHPNIIRMLGATCEKSNYNL--FIEWMAGASVAHLLSKYG 1320
>IGF1R_MOUSE (Q60751) Insulin-like growth factor 1 receptor precursor (EC| 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain] Length = 1373 Score = 46.6 bits (109), Expect = 3e-05 Identities = 35/108 (32%), Positives = 53/108 (49%), Gaps = 7/108 (6%) Frame = +3 Query: 135 IKNEDLEELRELGSGTFGTVYHGKWRG-------TDVAIKRIKKSCFTGRSSEQERLAQE 293 + E + RELG G+FG VY G +G T VAIK + ++ +S +ER+ E Sbjct: 995 VAREKITMNRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEA-----ASMRERI--E 1047 Query: 294 FWREAEILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQ 437 F EA ++ + + +VV GVV G + E M G L+ L+ Sbjct: 1048 FLNEASVMKEFNCHHVVRLLGVVSQGQ--PTLVIMELMTRGDLKSYLR 1093
>IGF1R_XENLA (O73798) Insulin-like growth factor 1 receptor precursor (EC| 2.7.10.1) (xIGF-1R) (xIGFR) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain] Length = 1358 Score = 46.6 bits (109), Expect = 3e-05 Identities = 35/108 (32%), Positives = 53/108 (49%), Gaps = 7/108 (6%) Frame = +3 Query: 135 IKNEDLEELRELGSGTFGTVYHGKWRG-------TDVAIKRIKKSCFTGRSSEQERLAQE 293 + E + RELG G+FG VY G +G T VAIK + ++ +S +ER+ E Sbjct: 990 VPREKITMNRELGQGSFGMVYEGIAKGVVKDEAETKVAIKTVNEA-----ASMRERI--E 1042 Query: 294 FWREAEILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQ 437 F EA ++ + + +VV GVV G + E M G L+ L+ Sbjct: 1043 FLNEASVMKEFNCHHVVRLLGVVSQGQ--PTLVIMELMTRGDLKSYLR 1088
>INSR_HUMAN (P06213) Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220| antigen) [Contains: Insulin receptor alpha subunit; Insulin receptor beta subunit] Length = 1382 Score = 46.6 bits (109), Expect = 3e-05 Identities = 38/108 (35%), Positives = 54/108 (50%), Gaps = 7/108 (6%) Frame = +3 Query: 135 IKNEDLEELRELGSGTFGTVYHGKWRG-------TDVAIKRIKKSCFTGRSSEQERLAQE 293 + E + LRELG G+FG VY G R T VA+K + +S +S +ER+ E Sbjct: 1018 VSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNES-----ASLRERI--E 1070 Query: 294 FWREAEILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQ 437 F EA ++ +VV GVV G TL + E M +G L+ L+ Sbjct: 1071 FLNEASVMKGFTCHHVVRLLGVVSKGQ-PTLVVM-ELMAHGDLKSYLR 1116
>INSRR_CAVPO (P14617) Insulin receptor-related protein precursor (EC 2.7.10.1)| (IRR) (IR-related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain] Length = 1300 Score = 46.6 bits (109), Expect = 3e-05 Identities = 34/108 (31%), Positives = 52/108 (48%), Gaps = 7/108 (6%) Frame = +3 Query: 135 IKNEDLEELRELGSGTFGTVYHGKWRG-------TDVAIKRIKKSCFTGRSSEQERLAQE 293 + E + +RELG G+FG VY G +G T VA+K + + +S +ER+ E Sbjct: 974 VPREQISIIRELGQGSFGMVYEGVAKGLEAGEESTPVALKTVNE-----LASPRERI--E 1026 Query: 294 FWREAEILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQ 437 F +EA ++ +VV GVV G + E M G L+ L+ Sbjct: 1027 FLKEASVMKAFQCHHVVRLLGVVSQGQ--PTLVIMELMTRGDLKSHLR 1072
>IRAK4_MOUSE (Q8R4K2) Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1)| (IRAK-4) Length = 459 Score = 46.2 bits (108), Expect = 5e-05 Identities = 37/133 (27%), Positives = 54/133 (40%), Gaps = 5/133 (3%) Frame = +3 Query: 39 PDFEEPKFEEDRTAAQVMDASLRDSDFEHLQIIKNEDLEEL-----RELGSGTFGTVYHG 203 PD P D + + D F L+ I N E+ +G G FG VY G Sbjct: 148 PDSSSP----DNRSVESSDTRFHSFSFHELKSITNNFDEQPASAGGNRMGEGGFGVVYKG 203 Query: 204 KWRGTDVAIKRIKKSCFTGRSSEQERLAQEFWREAEILSKLHHPNVVAFYGVVKDGPGGT 383 T VA+K++ E L Q+F +E ++++ H N+V G D Sbjct: 204 CVNNTIVAVKKLGAMV----EISTEELKQQFDQEIKVMATCQHENLVELLGFSSD--SDN 257 Query: 384 LATLTEFMVNGSL 422 L + +M NGSL Sbjct: 258 LCLVYAYMPNGSL 270
>MOS_PIG (P50118) Proto-oncogene serine/threonine-protein kinase mos (EC| 2.7.11.1) (c-mos) (Oocyte maturation factor mos) Length = 345 Score = 46.2 bits (108), Expect = 5e-05 Identities = 32/103 (31%), Positives = 49/103 (47%), Gaps = 3/103 (2%) Frame = +3 Query: 159 LRELGSGTFGTVYHGKWRGTDVAIKRIKKSCFTGRSSEQERLAQEFWREAEILSKLHHPN 338 L+ LG+G FG+VY + G VAIK++ + C R + Q + FW E I ++L H N Sbjct: 66 LQRLGAGGFGSVYKATYHGVPVAIKQVSR-CTKNRLASQ----RSFWAELNI-ARLRHAN 119 Query: 339 VVAFYGVVKDGPG---GTLATLTEFMVNGSLRHVLQRKGQCPD 458 +V P + + EF N +L V+ CP+ Sbjct: 120 IVRVVAASTRTPAAFDSLGSIIMEFGGNVTLHQVIYGATGCPE 162
>ROS_HUMAN (P08922) Proto-oncogene tyrosine-protein kinase ROS precursor (EC| 2.7.10.1) (c-ros-1) Length = 2347 Score = 46.2 bits (108), Expect = 5e-05 Identities = 32/90 (35%), Positives = 46/90 (51%), Gaps = 8/90 (8%) Frame = +3 Query: 114 DFEHLQIIKNEDLEELRELGSGTFGTVYHGK--------WRGTDVAIKRIKKSCFTGRSS 269 + E+L E L LGSG FG VY G VA+K +KK S+ Sbjct: 1933 EIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKG-----ST 1987 Query: 270 EQERLAQEFWREAEILSKLHHPNVVAFYGV 359 +QE++ EF +EA ++SK +HPN++ GV Sbjct: 1988 DQEKI--EFLKEAHLMSKFNHPNILKQLGV 2015
>BMR1A_MOUSE (P36895) Bone morphogenetic protein receptor type IA precursor (EC| 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (BMP-2/BMP-4 receptor) Length = 532 Score = 46.2 bits (108), Expect = 5e-05 Identities = 34/116 (29%), Positives = 55/116 (47%), Gaps = 4/116 (3%) Frame = +3 Query: 144 EDLEELRELGSGTFGTVYHGKWRGTDVAIKRIKKSCFTGRSSEQERLAQEFWREAEILSK 323 + ++ +R++G G +G V+ GKWRG VA+K FT + ++RE EI Sbjct: 232 KQIQMVRQVGKGRYGEVWMGKWRGEKVAVKVF----FTTEEA-------SWFRETEIYQT 280 Query: 324 --LHHPNVVAFYGVVKDGPGG--TLATLTEFMVNGSLRHVLQRKGQCPDLPQRLII 479 + H N++ F G G L +T++ NGSL L +C L R ++ Sbjct: 281 VLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDFL----KCATLDTRALL 332
>BMR1A_HUMAN (P36894) Bone morphogenetic protein receptor type IA precursor (EC| 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (CD292 antigen) Length = 532 Score = 46.2 bits (108), Expect = 5e-05 Identities = 34/116 (29%), Positives = 55/116 (47%), Gaps = 4/116 (3%) Frame = +3 Query: 144 EDLEELRELGSGTFGTVYHGKWRGTDVAIKRIKKSCFTGRSSEQERLAQEFWREAEILSK 323 + ++ +R++G G +G V+ GKWRG VA+K FT + ++RE EI Sbjct: 232 KQIQMVRQVGKGRYGEVWMGKWRGEKVAVKVF----FTTEEA-------SWFRETEIYQT 280 Query: 324 --LHHPNVVAFYGVVKDGPGG--TLATLTEFMVNGSLRHVLQRKGQCPDLPQRLII 479 + H N++ F G G L +T++ NGSL L +C L R ++ Sbjct: 281 VLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDFL----KCATLDTRALL 332
>SEA_AVIET (P23049) Tyrosine-protein kinase transforming protein SEA (EC| 2.7.10.2) Length = 370 Score = 46.2 bits (108), Expect = 5e-05 Identities = 30/107 (28%), Positives = 50/107 (46%), Gaps = 5/107 (4%) Frame = +3 Query: 162 RELGSGTFGTVYHGKWR-----GTDVAIKRIKKSCFTGRSSEQERLAQEFWREAEILSKL 326 R +G G FG+VYHG + A+K + + + +EF RE ++ Sbjct: 64 RVIGRGHFGSVYHGTYMDPLLGNLHCAVKSLHRITYLEE-------VEEFLREGILMKGF 116 Query: 327 HHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQRKGQCPDLPQ 467 HHP V++ GV G L L +M +G LRH ++ + + P + + Sbjct: 117 HHPQVLSLLGVCLPRHGLPLVVL-PYMRHGDLRHFVRAQERSPTVKE 162
>EPHB2_MOUSE (P54763) Ephrin type-B receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EPH-3) (Neural kinase) (Nuk receptor tyrosine kinase) (SEK-3) Length = 994 Score = 46.2 bits (108), Expect = 5e-05 Identities = 39/101 (38%), Positives = 50/101 (49%), Gaps = 7/101 (6%) Frame = +3 Query: 168 LGSGTFGTVYHGKW-----RGTDVAIKRIKKSCFTGRSSEQERLAQEFWREAEILSKLHH 332 +G+G FG V G R VAIK +K S E+ ++F EA I+ + H Sbjct: 635 IGAGEFGEVCSGHLKLPGKREIFVAIKTLK-------SGYTEKQRRDFLSEASIMGQFDH 687 Query: 333 PNVVAFYGVV-KDGPGGTLATLTEFMVNGSLRHVL-QRKGQ 449 PNV+ GVV K P + +TEFM NGSL L Q GQ Sbjct: 688 PNVIHLEGVVTKSTP---VMIITEFMENGSLDSFLRQNDGQ 725
>ILPR_BRALA (O02466) Insulin-like peptide receptor precursor (EC 2.7.10.1) (ILP| receptor) [Contains: Insulin-like peptide receptor alpha chain; Insulin-like peptide receptor beta chain] Length = 1363 Score = 46.2 bits (108), Expect = 5e-05 Identities = 36/109 (33%), Positives = 56/109 (51%), Gaps = 7/109 (6%) Frame = +3 Query: 135 IKNEDLEELRELGSGTFGTVYHGKWRG-------TDVAIKRIKKSCFTGRSSEQERLAQE 293 + E + +RELG G+FG VY G+ + VA+K + +S +S +ER+ E Sbjct: 989 VPREKITLIRELGQGSFGMVYEGEAKDVVKDEPMVSVAVKTVNES-----ASIRERI--E 1041 Query: 294 FWREAEILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQR 440 F EA ++ + +VV GVV G TL + E M G L++ L+R Sbjct: 1042 FLNEASVMKTFNCHHVVKLMGVVSKGQ-PTLVVM-ELMALGDLKNYLRR 1088
>EPHA5_HUMAN (P54756) Ephrin type-A receptor 5 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Receptor protein-tyrosine kinase HEK7) Length = 1037 Score = 46.2 bits (108), Expect = 5e-05 Identities = 36/99 (36%), Positives = 52/99 (52%), Gaps = 6/99 (6%) Frame = +3 Query: 162 RELGSGTFGTVYHGKW-----RGTDVAIKRIKKSCFTGRSSEQERLAQEFWREAEILSKL 326 R +G+G FG V G+ R VAIK +K G + +Q R +F EA I+ + Sbjct: 679 RVIGAGEFGEVCSGRLKLPGKRELPVAIKTLK----VGYTEKQRR---DFLGEASIMGQF 731 Query: 327 HHPNVVAFYGVV-KDGPGGTLATLTEFMVNGSLRHVLQR 440 HPN++ GVV K P + +TE+M NGSL L++ Sbjct: 732 DHPNIIHLEGVVTKSKP---VMIVTEYMENGSLDTFLKK 767
>ERBB_AVIEU (P11273) Tyrosine-protein kinase transforming protein erbB (EC| 2.7.10.1) Length = 540 Score = 46.2 bits (108), Expect = 5e-05 Identities = 32/121 (26%), Positives = 57/121 (47%), Gaps = 2/121 (1%) Frame = +3 Query: 66 EDRTAAQVMDASLRDSDFEHLQIIKNEDLEELRELGSGTFGTVYHGKW--RGTDVAIKRI 239 ++R + + S + HL+I+K + ++++ LG G FGTVY G W G V I Sbjct: 104 QERELVEPLTPSGEAPNQAHLRILKETEFKKVKVLGFGAFGTVYKGLWIPEGEKVTIPVA 163 Query: 240 KKSCFTGRSSEQERLAQEFWREAEILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGS 419 K R + + +E EA +++ + +P+V G+ T+ +T+ M G Sbjct: 164 IKEL---REATSPKANKEILDEAYVMASVDNPHVCRLLGICLT---STVQLITQLMPYGC 217 Query: 420 L 422 L Sbjct: 218 L 218
>ACV1C_RAT (P70539) Activin receptor type 1C precursor (EC 2.7.11.30)| (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7) Length = 493 Score = 46.2 bits (108), Expect = 5e-05 Identities = 34/95 (35%), Positives = 46/95 (48%), Gaps = 4/95 (4%) Frame = +3 Query: 168 LGSGTFGTVYHGKWRGTDVAIKRIKKSCFTGRSSEQERLAQEFWREAEILS--KLHHPNV 341 +G G FG V+HG+W G DVA+K SS ER ++REAEI L H N+ Sbjct: 201 VGKGRFGEVWHGRWCGEDVAVKIF--------SSRDER---SWFREAEIYQTVMLRHENI 249 Query: 342 VAFYGV--VKDGPGGTLATLTEFMVNGSLRHVLQR 440 + F +G L ++E+ GSL L R Sbjct: 250 LGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNR 284
>ACV1C_MOUSE (Q8K348) Activin receptor type 1C precursor (EC 2.7.11.30)| (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7) Length = 493 Score = 46.2 bits (108), Expect = 5e-05 Identities = 34/95 (35%), Positives = 46/95 (48%), Gaps = 4/95 (4%) Frame = +3 Query: 168 LGSGTFGTVYHGKWRGTDVAIKRIKKSCFTGRSSEQERLAQEFWREAEILS--KLHHPNV 341 +G G FG V+HG+W G DVA+K SS ER ++REAEI L H N+ Sbjct: 201 VGKGRFGEVWHGRWCGEDVAVKIF--------SSRDER---SWFREAEIYQTVMLRHENI 249 Query: 342 VAFYGV--VKDGPGGTLATLTEFMVNGSLRHVLQR 440 + F +G L ++E+ GSL L R Sbjct: 250 LGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNR 284
>ACV1C_HUMAN (Q8NER5) Activin receptor type 1C precursor (EC 2.7.11.30)| (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7) Length = 493 Score = 46.2 bits (108), Expect = 5e-05 Identities = 34/95 (35%), Positives = 46/95 (48%), Gaps = 4/95 (4%) Frame = +3 Query: 168 LGSGTFGTVYHGKWRGTDVAIKRIKKSCFTGRSSEQERLAQEFWREAEILS--KLHHPNV 341 +G G FG V+HG+W G DVA+K SS ER ++REAEI L H N+ Sbjct: 201 VGKGRFGEVWHGRWCGEDVAVKIF--------SSRDER---SWFREAEIYQTVMLRHENI 249 Query: 342 VAFYGV--VKDGPGGTLATLTEFMVNGSLRHVLQR 440 + F +G L ++E+ GSL L R Sbjct: 250 LGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNR 284
>EPHB3_XENLA (Q91735) Ephrin type-B receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor TCK) Length = 974 Score = 46.2 bits (108), Expect = 5e-05 Identities = 34/95 (35%), Positives = 48/95 (50%), Gaps = 5/95 (5%) Frame = +3 Query: 168 LGSGTFGTVYHGKWRGTD-----VAIKRIKKSCFTGRSSEQERLAQEFWREAEILSKLHH 332 +G+G FG V GK + VAIK +K G + +Q R +F EA I+ + H Sbjct: 615 IGAGEFGEVCRGKLKQAGRREQFVAIKTLK----AGYTEQQRR---DFLGEASIMGQFDH 667 Query: 333 PNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQ 437 PN++ GVV + LTEFM NG+L L+ Sbjct: 668 PNIIRLEGVVT--RSRPVMILTEFMENGALDSFLR 700
>EPHA3_BRARE (O13146) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ZEK1) (EPH-like kinase 1) Length = 981 Score = 46.2 bits (108), Expect = 5e-05 Identities = 35/98 (35%), Positives = 49/98 (50%), Gaps = 5/98 (5%) Frame = +3 Query: 162 RELGSGTFGTVYHGKWR-----GTDVAIKRIKKSCFTGRSSEQERLAQEFWREAEILSKL 326 R +G+G FG V G+ R VAIK +K G S Q R +F EA I+ + Sbjct: 630 RVIGAGEFGEVCSGRLRLPSKREIQVAIKSLK----AGYSEHQRR---DFLSEASIMGQF 682 Query: 327 HHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQR 440 HPN++ GVV + +TE+M NGSL L++ Sbjct: 683 DHPNIIRLEGVVTRCK--PVMIVTEYMENGSLDTFLKK 718
>WNK3_HUMAN (Q9BYP7) Serine/threonine-protein kinase WNK3 (EC 2.7.11.1)| (Protein kinase with no lysine 3) (Protein kinase, lysine-deficient 3) Length = 1743 Score = 46.2 bits (108), Expect = 5e-05 Identities = 34/94 (36%), Positives = 47/94 (50%), Gaps = 2/94 (2%) Frame = +3 Query: 165 ELGSGTFGTVYHGKWRGTDVAIKRIKKSCFTGRSSEQERLAQEFWREAEILSKLHHPNVV 344 ELG G F TVY G T V + + +EQ+R F EAE+L L HPN+V Sbjct: 152 ELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQR----FKEEAEMLKGLQHPNIV 207 Query: 345 AFYGVVKDGPGG--TLATLTEFMVNGSLRHVLQR 440 FY + G + +TE M +G+L+ L+R Sbjct: 208 RFYDSWESILKGKKCIVLVTELMTSGTLKTYLKR 241
>FUZ7_USTMA (Q99078) Dual specificity protein kinase FUZ7 (EC 2.7.12.2)| Length = 435 Score = 46.2 bits (108), Expect = 5e-05 Identities = 39/120 (32%), Positives = 62/120 (51%), Gaps = 4/120 (3%) Frame = +3 Query: 135 IKNEDLEELRELGSGTFGT---VYHGKWRGTDVAIKRIKKSCFTGRSSEQERLAQEFWRE 305 +KNEDL+ L ELG+G GT V H K GT +A KK F + + ++ RE Sbjct: 104 LKNEDLKTLSELGAGNGGTVTKVLHEK-SGTVMA----KKVVFI---DAKPSVRKQILRE 155 Query: 306 AEILSKLHHPNVVAFYGVVKDGPGGTLATLTEFMVNGSLRHVLQRKGQ-CPDLPQRLIIA 482 +IL + + P +V+FYG + P + EFM SL + ++ G P++ ++ +A Sbjct: 156 LQILHECNSPYIVSFYGAYLNEP--HICMCMEFMQKDSLDGIYKKYGPISPEICGKIAVA 213 Database: uniprot_sprot.fasta Posted date: May 25, 2006 5:36 PM Number of letters in database: 80,573,946 Number of sequences in database: 219,361 Lambda K H 0.318 0.135 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 73,904,527 Number of Sequences: 219361 Number of extensions: 1509566 Number of successful extensions: 7003 Number of sequences better than 10.0: 500 Number of HSP's better than 10.0 without gapping: 6389 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 6695 length of database: 80,573,946 effective HSP length: 103 effective length of database: 57,979,763 effective search space used: 3304846491 frameshift window, decay const: 50, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)
