ナショナルバイオリソースプロジェクト
-Barley Genetic Resources Database-
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| Clone Name | bast59d08 |
|---|---|
| Clone Library Name | barley_pub |
>PBS1_ARATH (Q9FE20) Serine/threonine-protein kinase PBS1 (EC 2.7.11.1)| (AvrPphB susceptible protein 1) Length = 456 Score = 132 bits (331), Expect = 6e-31 Identities = 72/143 (50%), Positives = 92/143 (64%), Gaps = 1/143 (0%) Frame = +3 Query: 24 TFSISELEKATDKFSFNRIIGEGGYGRVYRGIVQD-GVEVAVKLLTGKHQNRDREFIAEV 200 TF+ EL AT F + +GEGG+GRVY+G + G VAVK L +REF+ EV Sbjct: 73 TFAFRELAAATMNFHPDTFLGEGGFGRVYKGRLDSTGQVVAVKQLDRNGLQGNREFLVEV 132 Query: 201 EMLSRLHHRNLVKMIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIAL 380 MLS LHH NLV +IG C + R LV+E +P GS+E HLH LD++ RMKIA Sbjct: 133 LMLSLLHHPNLVNLIGYCADGDQRLLVYEFMPLGSLEDHLHDLPPDKEALDWNMRMKIAA 192 Query: 381 GAARGLAYLHEDANPHVIHRDFR 449 GAA+GL +LH+ ANP VI+RDF+ Sbjct: 193 GAAKGLEFLHDKANPPVIYRDFK 215
>NAK_ARATH (P43293) Probable serine/threonine-protein kinase NAK (EC 2.7.11.1)| Length = 389 Score = 131 bits (329), Expect = 1e-30 Identities = 68/154 (44%), Positives = 101/154 (65%), Gaps = 10/154 (6%) Frame = +3 Query: 18 VKTFSISELEKATDKFSFNRIIGEGGYGRVYRGIVQD----------GVEVAVKLLTGKH 167 +K FS+SEL+ AT F + ++GEGG+G V++G + + G+ +AVK L + Sbjct: 53 LKNFSLSELKSATRNFRPDSVVGEGGFGCVFKGWIDESSLAPSKPGTGIVIAVKRLNQEG 112 Query: 168 QNRDREFIAEVEMLSRLHHRNLVKMIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGP 347 RE++AE+ L +L H NLVK+IG C+E R LV+E + GS+E+HL Y P Sbjct: 113 FQGHREWLAEINYLGQLDHPNLVKLIGYCLEEEHRLLVYEFMTRGSLENHLFRRGTFYQP 172 Query: 348 LDFDTRMKIALGAARGLAYLHEDANPHVIHRDFR 449 L ++TR+++ALGAARGLA+LH +A P VI+RDF+ Sbjct: 173 LSWNTRVRMALGAARGLAFLH-NAQPQVIYRDFK 205
>PSKR_DAUCA (Q8LPB4) Phytosulfokine receptor precursor (EC 2.7.11.1)| (Phytosulfokine LRR receptor kinase) Length = 1021 Score = 129 bits (325), Expect = 3e-30 Identities = 65/142 (45%), Positives = 94/142 (66%), Gaps = 2/142 (1%) Frame = +3 Query: 30 SISELEKATDKFSFNRIIGEGGYGRVYRGIVQDGVEVAVKLLTGKHQNRDREFIAEVEML 209 S+ ++ K+T F+ IIG GG+G VY+ + DG +VA+K L+G DREF AEVE L Sbjct: 732 SLDDILKSTSSFNQANIIGCGGFGLVYKATLPDGTKVAIKRLSGDTGQMDREFQAEVETL 791 Query: 210 SRLHHRNLVKMIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGP--LDFDTRMKIALG 383 SR H NLV ++G C + + L++ + NGS++ LH +K+ GP LD+ TR++IA G Sbjct: 792 SRAQHPNLVHLLGYCNYKNDKLLIYSYMDNGSLDYWLH--EKVDGPPSLDWKTRLRIARG 849 Query: 384 AARGLAYLHEDANPHVIHRDFR 449 AA GLAYLH+ PH++HRD + Sbjct: 850 AAEGLAYLHQSCEPHILHRDIK 871
>BAK1_ARATH (Q94F62) BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1| precursor (EC 2.7.11.1) (BRI1-associated receptor kinase 1) (Somatic embryogenesis receptor-like kinase 3) Length = 615 Score = 129 bits (323), Expect = 5e-30 Identities = 68/147 (46%), Positives = 95/147 (64%), Gaps = 1/147 (0%) Frame = +3 Query: 18 VKTFSISELEKATDKFSFNRIIGEGGYGRVYRGIVQDGVEVAVKLLTGKH-QNRDREFIA 194 +K FS+ EL+ A+D FS I+G GG+G+VY+G + DG VAVK L + Q + +F Sbjct: 274 LKRFSLRELQVASDNFSNKNILGRGGFGKVYKGRLADGTLVAVKRLKEERTQGGELQFQT 333 Query: 195 EVEMLSRLHHRNLVKMIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKI 374 EVEM+S HRNL+++ G C+ R LV+ + NGSV S L + PLD+ R +I Sbjct: 334 EVEMISMAVHRNLLRLRGFCMTPTERLLVYPYMANGSVASCLRERPESQPPLDWPKRQRI 393 Query: 375 ALGAARGLAYLHEDANPHVIHRDFRLA 455 ALG+ARGLAYLH+ +P +IHRD + A Sbjct: 394 ALGSARGLAYLHDHCDPKIIHRDVKAA 420
>RLCK7_ARATH (Q9LQQ8) Probable serine/threonine-protein kinase RLCKVII (EC| 2.7.11.1) Length = 423 Score = 127 bits (318), Expect = 2e-29 Identities = 73/149 (48%), Positives = 94/149 (63%), Gaps = 2/149 (1%) Frame = +3 Query: 21 KTFSISELEKATDKFSFNRIIGEGGYGRVYRGIVQ--DGVEVAVKLLTGKHQNRDREFIA 194 +TF+ EL +AT F + +GEGG+G+V++G ++ D V VA+K L REF+ Sbjct: 89 QTFTFQELAEATGNFRSDCFLGEGGFGKVFKGTIEKLDQV-VAIKQLDRNGVQGIREFVV 147 Query: 195 EVEMLSRLHHRNLVKMIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKI 374 EV LS H NLVK+IG C E R LV+E +P GS+E HLH PLD++TRMKI Sbjct: 148 EVLTLSLADHPNLVKLIGFCAEGDQRLLVYEYMPQGSLEDHLHVLPSGKKPLDWNTRMKI 207 Query: 375 ALGAARGLAYLHEDANPHVIHRDFRLACS 461 A GAARGL YLH+ P VI+RD L CS Sbjct: 208 AAGAARGLEYLHDRMTPPVIYRD--LKCS 234
>BRI1_ARATH (O22476) BRASSINOSTEROID INSENSITIVE 1 precursor (EC 2.7.11.1)| (AtBRI1) (Brassinosteroid LRR receptor kinase) Length = 1196 Score = 127 bits (318), Expect = 2e-29 Identities = 62/144 (43%), Positives = 95/144 (65%) Frame = +3 Query: 18 VKTFSISELEKATDKFSFNRIIGEGGYGRVYRGIVQDGVEVAVKLLTGKHQNRDREFIAE 197 ++ + ++L +AT+ F + +IG GG+G VY+ I++DG VA+K L DREF+AE Sbjct: 868 LRKLTFADLLQATNGFHNDSLIGSGGFGDVYKAILKDGSAVAIKKLIHVSGQGDREFMAE 927 Query: 198 VEMLSRLHHRNLVKMIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIA 377 +E + ++ HRNLV ++G C R LV+E + GS+E LH K L++ TR KIA Sbjct: 928 METIGKIKHRNLVPLLGYCKVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIA 987 Query: 378 LGAARGLAYLHEDANPHVIHRDFR 449 +G+ARGLA+LH + +PH+IHRD + Sbjct: 988 IGSARGLAFLHHNCSPHIIHRDMK 1011
>APK1B_ARATH (P46573) Protein kinase APK1B, chloroplast precursor (EC 2.7.11.1)| Length = 412 Score = 124 bits (310), Expect = 2e-28 Identities = 65/156 (41%), Positives = 98/156 (62%), Gaps = 10/156 (6%) Frame = +3 Query: 12 PTVKTFSISELEKATDKFSFNRIIGEGGYGRVYRGIVQD----------GVEVAVKLLTG 161 P +K+F+ +EL+ AT F + ++GEGG+G V++G + + GV +AVK L Sbjct: 52 PNLKSFTFAELKAATRNFRPDSVLGEGGFGSVFKGWIDEQTLTASKPGTGVVIAVKKLNQ 111 Query: 162 KHQNRDREFIAEVEMLSRLHHRNLVKMIGICIERRTRCLVFELVPNGSVESHLHGSDKIY 341 +E++AEV L + H NLVK+IG C+E R LV+E +P GS+E+HL + Sbjct: 112 DGWQGHQEWLAEVNYLGQFSHPNLVKLIGYCLEDEHRLLVYEFMPRGSLENHLFRRGSYF 171 Query: 342 GPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFR 449 PL + R+K+ALGAA+GLA+LH +A VI+RDF+ Sbjct: 172 QPLSWTLRLKVALGAAKGLAFLH-NAETSVIYRDFK 206
>APK1A_ARATH (Q06548) Protein kinase APK1A, chloroplast precursor (EC 2.7.11.1)| Length = 410 Score = 122 bits (306), Expect = 5e-28 Identities = 64/156 (41%), Positives = 98/156 (62%), Gaps = 10/156 (6%) Frame = +3 Query: 12 PTVKTFSISELEKATDKFSFNRIIGEGGYGRVYRGIVQD----------GVEVAVKLLTG 161 P +K+FS +EL+ AT F + ++GEGG+G V++G + + G+ +AVK L Sbjct: 51 PNLKSFSFAELKSATRNFRPDSVLGEGGFGCVFKGWIDEKSLTASRPGTGLVIAVKKLNQ 110 Query: 162 KHQNRDREFIAEVEMLSRLHHRNLVKMIGICIERRTRCLVFELVPNGSVESHLHGSDKIY 341 +E++AEV L + HR+LVK+IG C+E R LV+E +P GS+E+HL + Sbjct: 111 DGWQGHQEWLAEVNYLGQFSHRHLVKLIGYCLEDEHRLLVYEFMPRGSLENHLFRRGLYF 170 Query: 342 GPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFR 449 PL + R+K+ALGAA+GLA+LH + VI+RDF+ Sbjct: 171 QPLSWKLRLKVALGAAKGLAFLH-SSETRVIYRDFK 205
>NORK_PEA (Q8LKZ1) Nodulation receptor kinase precursor (EC 2.7.11.1)| Length = 924 Score = 122 bits (305), Expect = 6e-28 Identities = 66/145 (45%), Positives = 90/145 (62%) Frame = +3 Query: 15 TVKTFSISELEKATDKFSFNRIIGEGGYGRVYRGIVQDGVEVAVKLLTGKHQNRDREFIA 194 +VK F++ +E AT+K+ +IGEGG+G VYRG + DG EVAVK+ + REF Sbjct: 581 SVKPFTLEYIELATEKYK--TLIGEGGFGSVYRGTLDDGQEVAVKVRSATSTQGTREFDN 638 Query: 195 EVEMLSRLHHRNLVKMIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKI 374 E+ +LS + H NLV ++G C E + LV+ + NGS+ L+G LD+ TR+ I Sbjct: 639 ELNLLSAIQHENLVPLLGYCNEYDQQILVYPFMSNGSLLDRLYGEPAKRKILDWPTRLSI 698 Query: 375 ALGAARGLAYLHEDANPHVIHRDFR 449 ALGAARGLAYLH VIHRD + Sbjct: 699 ALGAARGLAYLHTFPGRSVIHRDVK 723
>BRI1_LYCES (Q8GUQ5) Brassinosteroid LRR receptor kinase precursor (EC 2.7.11.1)| (tBRI1) (Altered brassinolide sensitivity 1) (Systemin receptor SR160) Length = 1207 Score = 122 bits (305), Expect = 6e-28 Identities = 61/144 (42%), Positives = 92/144 (63%) Frame = +3 Query: 18 VKTFSISELEKATDKFSFNRIIGEGGYGRVYRGIVQDGVEVAVKLLTGKHQNRDREFIAE 197 ++ + ++L +AT+ F + ++G GG+G VY+ ++DG VA+K L DREF AE Sbjct: 873 LRKLTFADLLEATNGFHNDSLVGSGGFGDVYKAQLKDGSVVAIKKLIHVSGQGDREFTAE 932 Query: 198 VEMLSRLHHRNLVKMIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIA 377 +E + ++ HRNLV ++G C R LV+E + GS+E LH KI L++ R KIA Sbjct: 933 METIGKIKHRNLVPLLGYCKVGEERLLVYEYMKYGSLEDVLHDRKKIGIKLNWPARRKIA 992 Query: 378 LGAARGLAYLHEDANPHVIHRDFR 449 +GAARGLA+LH + PH+IHRD + Sbjct: 993 IGAARGLAFLHHNCIPHIIHRDMK 1016
>NORK_MEDTR (Q8L4H4) Nodulation receptor kinase precursor (EC 2.7.11.1) (Does not| make infections protein 2) (Symbiosis receptor-like kinase) (MtSYMRK) Length = 925 Score = 121 bits (304), Expect = 8e-28 Identities = 65/145 (44%), Positives = 91/145 (62%) Frame = +3 Query: 15 TVKTFSISELEKATDKFSFNRIIGEGGYGRVYRGIVQDGVEVAVKLLTGKHQNRDREFIA 194 +VK F++ +E+AT+++ +IGEGG+G VYRG + DG EVAVK+ + REF Sbjct: 582 SVKPFTLEYIEQATEQYK--TLIGEGGFGSVYRGTLDDGQEVAVKVRSSTSTQGTREFDN 639 Query: 195 EVEMLSRLHHRNLVKMIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKI 374 E+ +LS + H NLV ++G C E + LV+ + NGS+ L+G LD+ TR+ I Sbjct: 640 ELNLLSAIQHENLVPLLGYCNEYDQQILVYPFMSNGSLLDRLYGEASKRKILDWPTRLSI 699 Query: 375 ALGAARGLAYLHEDANPHVIHRDFR 449 ALGAARGLAYLH VIHRD + Sbjct: 700 ALGAARGLAYLHTFPGRSVIHRDVK 724
>BRL3_ARATH (Q9LJF3) Serine/threonine-protein kinase BRI1-like 3 precursor (EC| 2.7.11.1) (BRASSINOSTEROID INSENSITIVE 1-like protein 3) Length = 1164 Score = 120 bits (302), Expect = 1e-27 Identities = 64/145 (44%), Positives = 92/145 (63%), Gaps = 1/145 (0%) Frame = +3 Query: 18 VKTFSISELEKATDKFSFNRIIGEGGYGRVYRGIVQDGVEVAVKLLTGKHQNRDREFIAE 197 ++ + + L +AT+ FS + +IG GG+G VY+ + DG VA+K L DREF+AE Sbjct: 843 LRKLTFAHLLEATNGFSADSMIGSGGFGDVYKAKLADGSVVAIKKLIQVTGQGDREFMAE 902 Query: 198 VEMLSRLHHRNLVKMIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGP-LDFDTRMKI 374 +E + ++ HRNLV ++G C R LV+E + GS+E+ LH K G LD+ R KI Sbjct: 903 METIGKIKHRNLVPLLGYCKIGEERLLVYEYMKYGSLETVLHEKTKKGGIFLDWSARKKI 962 Query: 375 ALGAARGLAYLHEDANPHVIHRDFR 449 A+GAARGLA+LH PH+IHRD + Sbjct: 963 AIGAARGLAFLHHSCIPHIIHRDMK 987
>PSKR_ARATH (Q9ZVR7) Putative phytosulfokine receptor precursor (EC 2.7.11.1)| (Phytosulfokine LRR receptor kinase) Length = 1008 Score = 120 bits (301), Expect = 2e-27 Identities = 62/143 (43%), Positives = 88/143 (61%) Frame = +3 Query: 21 KTFSISELEKATDKFSFNRIIGEGGYGRVYRGIVQDGVEVAVKLLTGKHQNRDREFIAEV 200 K S +L +T+ F IIG GG+G VY+ + DG +VA+K L+G +REF AEV Sbjct: 720 KELSYDDLLDSTNSFDQANIIGCGGFGMVYKATLPDGKKVAIKKLSGDCGQIEREFEAEV 779 Query: 201 EMLSRLHHRNLVKMIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIAL 380 E LSR H NLV + G C + R L++ + NGS++ LH + L + TR++IA Sbjct: 780 ETLSRAQHPNLVLLRGFCFYKNDRLLIYSYMENGSLDYWLHERNDGPALLKWKTRLRIAQ 839 Query: 381 GAARGLAYLHEDANPHVIHRDFR 449 GAA+GL YLHE +PH++HRD + Sbjct: 840 GAAKGLLYLHEGCDPHILHRDIK 862
>BRI1_LYCPE (Q8L899) Systemin receptor SR160 precursor (EC 2.7.11.1)| (Brassinosteroid LRR receptor kinase) Length = 1207 Score = 120 bits (300), Expect = 2e-27 Identities = 60/144 (41%), Positives = 91/144 (63%) Frame = +3 Query: 18 VKTFSISELEKATDKFSFNRIIGEGGYGRVYRGIVQDGVEVAVKLLTGKHQNRDREFIAE 197 ++ + ++L +AT+ F + ++G GG+G VY+ ++DG VA+K L DREF AE Sbjct: 873 LRKLTFADLLEATNGFHNDSLVGSGGFGDVYKAQLKDGSVVAIKKLIHVSGQGDREFTAE 932 Query: 198 VEMLSRLHHRNLVKMIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIA 377 +E + ++ HRNLV ++G C R LV+E + GS+E LH K L++ R KIA Sbjct: 933 METIGKIKHRNLVPLLGYCKVGEERLLVYEYMKYGSLEDVLHDRKKTGIKLNWPARRKIA 992 Query: 378 LGAARGLAYLHEDANPHVIHRDFR 449 +GAARGLA+LH + PH+IHRD + Sbjct: 993 IGAARGLAFLHHNCIPHIIHRDMK 1016
>EXS_ARATH (Q9LYN8) Leucine-rich repeat receptor protein kinase EXS precursor| (EC 2.7.11.1) (Extra sporogenous cells protein) (EXCESS MICROSPOROCYTES1 protein) Length = 1192 Score = 117 bits (294), Expect = 1e-26 Identities = 59/139 (42%), Positives = 87/139 (62%) Frame = +3 Query: 33 ISELEKATDKFSFNRIIGEGGYGRVYRGIVQDGVEVAVKLLTGKHQNRDREFIAEVEMLS 212 + ++ +ATD FS IIG+GG+G VY+ + VAVK L+ +REF+AE+E L Sbjct: 907 LGDIVEATDHFSKKNIIGDGGFGTVYKACLPGEKTVAVKKLSEAKTQGNREFMAEMETLG 966 Query: 213 RLHHRNLVKMIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAAR 392 ++ H NLV ++G C + LV+E + NGS++ L + LD+ R+KIA+GAAR Sbjct: 967 KVKHPNLVSLLGYCSFSEEKLLVYEYMVNGSLDHWLRNQTGMLEVLDWSKRLKIAVGAAR 1026 Query: 393 GLAYLHEDANPHVIHRDFR 449 GLA+LH PH+IHRD + Sbjct: 1027 GLAFLHHGFIPHIIHRDIK 1045
>BRL1_ARATH (Q9ZWC8) Serine/threonine-protein kinase BRI1-like 1 precursor (EC| 2.7.11.1) (BRASSINOSTEROID INSENSITIVE 1-like protein 1) Length = 1166 Score = 117 bits (292), Expect = 2e-26 Identities = 61/146 (41%), Positives = 91/146 (62%), Gaps = 2/146 (1%) Frame = +3 Query: 18 VKTFSISELEKATDKFSFNRIIGEGGYGRVYRGIVQDGVEVAVKLLTGKHQNRDREFIAE 197 ++ + + L +AT+ FS ++G GG+G VY+ ++DG VA+K L DREF+AE Sbjct: 844 LRKLTFAHLLEATNGFSAETMVGSGGFGEVYKAQLRDGSVVAIKKLIRITGQGDREFMAE 903 Query: 198 VEMLSRLHHRNLVKMIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGP--LDFDTRMK 371 +E + ++ HRNLV ++G C R LV+E + GS+E+ LH G L++ R K Sbjct: 904 METIGKIKHRNLVPLLGYCKVGEERLLVYEYMKWGSLETVLHEKSSKKGGIYLNWAARKK 963 Query: 372 IALGAARGLAYLHEDANPHVIHRDFR 449 IA+GAARGLA+LH PH+IHRD + Sbjct: 964 IAIGAARGLAFLHHSCIPHIIHRDMK 989
>BRL2_ARATH (Q9ZPS9) Serine/threonine-protein kinase BRI1-like 2 precursor (EC| 2.7.11.1) (BRASSINOSTEROID INSENSITIVE 1-like protein 2) (Protein VASCULAR HIGHWAY 1) Length = 1143 Score = 116 bits (290), Expect = 3e-26 Identities = 61/146 (41%), Positives = 91/146 (62%), Gaps = 2/146 (1%) Frame = +3 Query: 18 VKTFSISELEKATDKFSFNRIIGEGGYGRVYRGIVQDGVEVAVKLLTGKHQNRDREFIAE 197 ++ S+L +AT+ FS +IG GG+G V++ ++DG VA+K L DREF+AE Sbjct: 823 LRKLKFSQLIEATNGFSAASMIGHGGFGEVFKATLKDGSSVAIKKLIRLSCQGDREFMAE 882 Query: 198 VEMLSRLHHRNLVKMIGICIERRTRCLVFELVPNGSVESHLHG--SDKIYGPLDFDTRMK 371 +E L ++ HRNLV ++G C R LV+E + GS+E LHG + + L ++ R K Sbjct: 883 METLGKIKHRNLVPLLGYCKIGEERLLVYEFMQYGSLEEVLHGPRTGEKRRILGWEERKK 942 Query: 372 IALGAARGLAYLHEDANPHVIHRDFR 449 IA GAA+GL +LH + PH+IHRD + Sbjct: 943 IAKGAAKGLCFLHHNCIPHIIHRDMK 968
>CLV1_ARATH (Q9SYQ8) Receptor protein kinase CLAVATA1 precursor (EC 2.7.11.1)| Length = 980 Score = 111 bits (277), Expect = 1e-24 Identities = 55/125 (44%), Positives = 84/125 (67%), Gaps = 1/125 (0%) Frame = +3 Query: 78 IIGEGGYGRVYRGIVQDGVEVAVKLLTGKHQNR-DREFIAEVEMLSRLHHRNLVKMIGIC 254 IIG+GG G VYRG + + V+VA+K L G+ R D F AE++ L R+ HR++V+++G Sbjct: 697 IIGKGGAGIVYRGSMPNNVDVAIKRLVGRGTGRSDHGFTAEIQTLGRIRHRHIVRLLGYV 756 Query: 255 IERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVI 434 + T L++E +PNGS+ LHGS G L ++TR ++A+ AA+GL YLH D +P ++ Sbjct: 757 ANKDTNLLLYEYMPNGSLGELLHGSKG--GHLQWETRHRVAVEAAKGLCYLHHDCSPLIL 814 Query: 435 HRDFR 449 HRD + Sbjct: 815 HRDVK 819
>CX32_ARATH (P27450) Probable serine/threonine-protein kinase Cx32, chloroplast| precursor (EC 2.7.11.1) Length = 419 Score = 111 bits (277), Expect = 1e-24 Identities = 63/156 (40%), Positives = 92/156 (58%), Gaps = 10/156 (6%) Frame = +3 Query: 12 PTVKTFSISELEKATDKFSFNRIIGEGGYGRVYRGIVQ----------DGVEVAVKLLTG 161 P +K ++ +L+ AT F + ++G+GG+G+VYRG V G+ VA+K L Sbjct: 69 PNLKVYNFLDLKTATKNFKPDSMLGQGGFGKVYRGWVDATTLAPSRVGSGMIVAIKRLNS 128 Query: 162 KHQNRDREFIAEVEMLSRLHHRNLVKMIGICIERRTRCLVFELVPNGSVESHLHGSDKIY 341 + E+ +EV L L HRNLVK++G C E + LV+E +P GS+ESHL + Sbjct: 129 ESVQGFAEWRSEVNFLGMLSHRNLVKLLGYCREDKELLLVYEFMPKGSLESHLFRRN--- 185 Query: 342 GPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFR 449 P +D R+KI +GAARGLA+LH VI+RDF+ Sbjct: 186 DPFPWDLRIKIVIGAARGLAFLH-SLQREVIYRDFK 220
>CRI4_MAIZE (O24585) Putative receptor protein kinase CRINKLY4 precursor (EC| 2.7.11.1) Length = 901 Score = 109 bits (273), Expect = 3e-24 Identities = 60/144 (41%), Positives = 92/144 (63%), Gaps = 3/144 (2%) Frame = +3 Query: 27 FSISELEKATDKFSFNRIIGEGGYGRVYRGIVQDGVEVAVK--LLTGKHQNRDREFIAEV 200 FS ELE+AT FS + +G+G + V++GI++DG VAVK + + +EF E+ Sbjct: 493 FSYEELEQATGGFSEDSQVGKGSFSCVFKGILRDGTVVAVKRAIKASDVKKSSKEFHNEL 552 Query: 201 EMLSRLHHRNLVKMIGICIERRTRCLVFELVPNGSVESHLHGSD-KIYGPLDFDTRMKIA 377 ++LSRL+H +L+ ++G C + R LV+E + +GS+ HLHG D + L++ R+ IA Sbjct: 553 DLLSRLNHAHLLNLLGYCEDGSERLLVYEFMAHGSLYQHLHGKDPNLKKRLNWARRVTIA 612 Query: 378 LGAARGLAYLHEDANPHVIHRDFR 449 + AARG+ YLH A P VIHRD + Sbjct: 613 VQAARGIEYLHGYACPPVIHRDIK 636
>SRK6_BRAOE (Q09092) Putative serine/threonine-protein kinase receptor| precursor (EC 2.7.11.1) (S-receptor kinase) (SRK) Length = 849 Score = 108 bits (271), Expect = 5e-24 Identities = 56/136 (41%), Positives = 88/136 (64%) Frame = +3 Query: 48 KATDKFSFNRIIGEGGYGRVYRGIVQDGVEVAVKLLTGKHQNRDREFIAEVEMLSRLHHR 227 KAT+ FS +G+GG+G VY+G + DG E+AVK L+ EF+ EV +++RL H Sbjct: 523 KATENFSSCNKLGQGGFGIVYKGRLLDGKEIAVKRLSKTSVQGTDEFMNEVTLIARLQHI 582 Query: 228 NLVKMIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYL 407 NLV+++G CIE + L++E + N S++S+L G + L+++ R I G ARGL YL Sbjct: 583 NLVQVLGCCIEGDEKMLIYEYLENLSLDSYLFGKTR-RSKLNWNERFDITNGVARGLLYL 641 Query: 408 HEDANPHVIHRDFRLA 455 H+D+ +IHRD +++ Sbjct: 642 HQDSRFRIIHRDLKVS 657
>SIRK_ARATH (O64483) Senescence-induced receptor-like serine/threonine-protein| kinase precursor (FLG22-induced receptor-like kinase 1) Length = 876 Score = 107 bits (267), Expect = 2e-23 Identities = 55/141 (39%), Positives = 89/141 (63%) Frame = +3 Query: 27 FSISELEKATDKFSFNRIIGEGGYGRVYRGIVQDGVEVAVKLLTGKHQNRDREFIAEVEM 206 F SE+ T+ +F R+IG+GG+G+VY G++ +G +VAVK+L+ + +EF AEV++ Sbjct: 564 FKYSEVVNITN--NFERVIGKGGFGKVYHGVI-NGEQVAVKVLSEESAQGYKEFRAEVDL 620 Query: 207 LSRLHHRNLVKMIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGA 386 L R+HH NL ++G C E L++E + N ++ +L G L ++ R+KI+L A Sbjct: 621 LMRVHHTNLTSLVGYCNEINHMVLIYEYMANENLGDYLAGKRSFI--LSWEERLKISLDA 678 Query: 387 ARGLAYLHEDANPHVIHRDFR 449 A+GL YLH P ++HRD + Sbjct: 679 AQGLEYLHNGCKPPIVHRDVK 699
>TMK1_ARATH (P43298) Putative receptor protein kinase TMK1 precursor (EC| 2.7.11.1) Length = 942 Score = 100 bits (249), Expect = 2e-21 Identities = 55/146 (37%), Positives = 89/146 (60%), Gaps = 6/146 (4%) Frame = +3 Query: 30 SISELEKATDKFSFNRIIGEGGYGRVYRGIVQDGVEVAVK-----LLTGKHQNRDREFIA 194 SI L T+ FS + I+G GG+G VY+G + DG ++AVK ++ GK EF + Sbjct: 577 SIQVLRSVTNNFSSDNILGSGGFGVVYKGELHDGTKIAVKRMENGVIAGKGF---AEFKS 633 Query: 195 EVEMLSRLHHRNLVKMIGICIERRTRCLVFELVPNGSVESHL-HGSDKIYGPLDFDTRMK 371 E+ +L+++ HR+LV ++G C++ + LV+E +P G++ HL S++ PL + R+ Sbjct: 634 EIAVLTKVRHRHLVTLLGYCLDGNEKLLVYEYMPQGTLSRHLFEWSEEGLKPLLWKQRLT 693 Query: 372 IALGAARGLAYLHEDANPHVIHRDFR 449 +AL ARG+ YLH A+ IHRD + Sbjct: 694 LALDVARGVEYLHGLAHQSFIHRDLK 719
>IRAK1_HUMAN (P51617) Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1)| (IRAK-1) Length = 712 Score = 99.4 bits (246), Expect = 4e-21 Identities = 58/146 (39%), Positives = 82/146 (56%), Gaps = 7/146 (4%) Frame = +3 Query: 33 ISELEKATDKFSFNRIIGEGGYGRVYRGIVQDGVEVAVKLLTGKHQNRDRE-------FI 191 + E+ + T FS IGEGG+G VYR ++++ V AVK L +N D E F+ Sbjct: 202 LCEISRGTHNFSEELKIGEGGFGCVYRAVMRNTV-YAVKRLK---ENADLEWTAVKQSFL 257 Query: 192 AEVEMLSRLHHRNLVKMIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMK 371 EVE LSR H N+V G C + CLV+ +PNGS+E LH + PL + R+ Sbjct: 258 TEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLD 317 Query: 372 IALGAARGLAYLHEDANPHVIHRDFR 449 I LG AR + +LH+D +P +IH D + Sbjct: 318 ILLGTARAIQFLHQD-SPSLIHGDIK 342
>IRAK1_MOUSE (Q62406) Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1)| (IRAK-1) (IRAK) (Pelle-like protein kinase) (mPLK) Length = 710 Score = 96.7 bits (239), Expect = 3e-20 Identities = 56/150 (37%), Positives = 81/150 (54%), Gaps = 4/150 (2%) Frame = +3 Query: 12 PTVKTFSISELEKATDKFSFNRIIGEGGYGRVYRGIVQDGVEVAVKLLTGKHQNR----D 179 P+ + E+ + T FS IGEGG+G VYR ++++ AVK L + Sbjct: 195 PSPFCWPFCEISQGTCNFSEELRIGEGGFGCVYRAVMRN-TTYAVKRLKEEADLEWTMVK 253 Query: 180 REFIAEVEMLSRLHHRNLVKMIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFD 359 + F+ EVE LSR H N+V G C E CLV+ +PNGS+E LH + PL + Sbjct: 254 QSFLTEVEQLSRFRHPNIVDFAGYCAESGLYCLVYGFLPNGSLEDQLHLQTQACSPLSWP 313 Query: 360 TRMKIALGAARGLAYLHEDANPHVIHRDFR 449 R+ I LG AR + +LH+D +P +IH D + Sbjct: 314 QRLDILLGTARAIQFLHQD-SPSLIHGDIK 342
>KPRO_MAIZE (P17801) Putative receptor protein kinase ZmPK1 precursor (EC| 2.7.11.1) Length = 817 Score = 95.5 bits (236), Expect = 6e-20 Identities = 60/145 (41%), Positives = 85/145 (58%), Gaps = 2/145 (1%) Frame = +3 Query: 21 KTFSISELEKATDKFSFNRIIGEGGYGRVYRGIVQDGVEVAVKLLTGKHQNRDREFIAEV 200 + +S EL KAT KF +G G G VY+G+++D VAVK L Q ++ F AE+ Sbjct: 522 RRYSYRELVKATRKFKVE--LGRGESGTVYKGVLEDDRHVAVKKLENVRQGKE-VFQAEL 578 Query: 201 EMLSRLHHRNLVKMIGICIERRTRCLVFELVPNGSVESHL--HGSDKIYGPLDFDTRMKI 374 ++ R++H NLV++ G C E R LV E V NGS+ + L G + + LD++ R I Sbjct: 579 SVIGRINHMNLVRIWGFCSEGSHRLLVSEYVENGSLANILFSEGGNIL---LDWEGRFNI 635 Query: 375 ALGAARGLAYLHEDANPHVIHRDFR 449 ALG A+GLAYLH + VIH D + Sbjct: 636 ALGVAKGLAYLHHECLEWVIHCDVK 660
>RLK5_ARATH (P47735) Receptor-like protein kinase 5 precursor (EC 2.7.11.1)| Length = 999 Score = 89.0 bits (219), Expect = 6e-18 Identities = 55/151 (36%), Positives = 80/151 (52%), Gaps = 10/151 (6%) Frame = +3 Query: 27 FSISELEKATDKFSFNRIIGEGGYGRVYRGIVQDGVEVAVKLLTGKHQNRDRE------- 185 FS E+ D+ +IG G G+VY+ ++ G VAVK L + D E Sbjct: 674 FSEHEIADCLDE---KNVIGFGSSGKVYKVELRGGEVVAVKKLNKSVKGGDDEYSSDSLN 730 Query: 186 ---FIAEVEMLSRLHHRNLVKMIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDF 356 F AEVE L + H+++V++ C + LV+E +PNGS+ LHG K L + Sbjct: 731 RDVFAAEVETLGTIRHKSIVRLWCCCSSGDCKLLVYEYMPNGSLADVLHGDRKGGVVLGW 790 Query: 357 DTRMKIALGAARGLAYLHEDANPHVIHRDFR 449 R++IAL AA GL+YLH D P ++HRD + Sbjct: 791 PERLRIALDAAEGLSYLHHDCVPPIVHRDVK 821
>RPK1_IPONI (P93194) Receptor-like protein kinase precursor (EC 2.7.11.1)| Length = 1109 Score = 87.0 bits (214), Expect = 2e-17 Identities = 44/140 (31%), Positives = 81/140 (57%), Gaps = 1/140 (0%) Frame = +3 Query: 33 ISELEKATDKFSFNRIIGEGGYGRVYRGIVQ-DGVEVAVKLLTGKHQNRDREFIAEVEML 209 ++++ +AT+ + +IG+G +G +Y+ + D V KL+ +N + E+E + Sbjct: 806 LNKVLEATENLNDKYVIGKGAHGTIYKATLSPDKVYAVKKLVFTGIKNGSVSMVREIETI 865 Query: 210 SRLHHRNLVKMIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAA 389 ++ HRNL+K+ + + +++ + NGS+ LH ++ PLD+ TR IA+G A Sbjct: 866 GKVRHRNLIKLEEFWLRKEYGLILYTYMENGSLHDILHETNPPK-PLDWSTRHNIAVGTA 924 Query: 390 RGLAYLHEDANPHVIHRDFR 449 GLAYLH D +P ++HRD + Sbjct: 925 HGLAYLHFDCDPAIVHRDIK 944
>IRAK4_HUMAN (Q9NWZ3) Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1)| (IRAK-4) (NY-REN-64 antigen) Length = 460 Score = 84.3 bits (207), Expect = 1e-16 Identities = 56/154 (36%), Positives = 84/154 (54%), Gaps = 10/154 (6%) Frame = +3 Query: 24 TFSISELEKATDKFSFNRI------IGEGGYGRVYRGIVQDGVEVAVKLLTGK----HQN 173 +FS EL+ T+ F I +GEGG+G VY+G V + VAVK L + Sbjct: 167 SFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNN-TTVAVKKLAAMVDITTEE 225 Query: 174 RDREFIAEVEMLSRLHHRNLVKMIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLD 353 ++F E++++++ H NLV+++G + CLV+ +PNGS+ L D PL Sbjct: 226 LKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGT-PPLS 284 Query: 354 FDTRMKIALGAARGLAYLHEDANPHVIHRDFRLA 455 + R KIA GAA G+ +LHE+ H IHRD + A Sbjct: 285 WHMRCKIAQGAANGINFLHEN---HHIHRDIKSA 315
>IRAK4_MOUSE (Q8R4K2) Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1)| (IRAK-4) Length = 459 Score = 84.0 bits (206), Expect = 2e-16 Identities = 56/155 (36%), Positives = 85/155 (54%), Gaps = 11/155 (7%) Frame = +3 Query: 24 TFSISELEKATDKFSF-------NRIIGEGGYGRVYRGIVQDGVEVAVKLLTG----KHQ 170 +FS EL+ T+ F NR+ GEGG+G VY+G V + + VAVK L + Sbjct: 167 SFSFHELKSITNNFDEQPASAGGNRM-GEGGFGVVYKGCVNNTI-VAVKKLGAMVEISTE 224 Query: 171 NRDREFIAEVEMLSRLHHRNLVKMIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPL 350 ++F E+++++ H NLV+++G + CLV+ +PNGS+ L D PL Sbjct: 225 ELKQQFDQEIKVMATCQHENLVELLGFSSDSDNLCLVYAYMPNGSLLDRLSCLDGT-PPL 283 Query: 351 DFDTRMKIALGAARGLAYLHEDANPHVIHRDFRLA 455 + TR K+A G A G+ +LHE+ H IHRD + A Sbjct: 284 SWHTRCKVAQGTANGIRFLHEN---HHIHRDIKSA 315
>KPEL_DROME (Q05652) Probable serine/threonine-protein kinase pelle (EC| 2.7.11.1) Length = 501 Score = 83.6 bits (205), Expect = 2e-16 Identities = 49/148 (33%), Positives = 85/148 (57%), Gaps = 8/148 (5%) Frame = +3 Query: 36 SELEKATDKFSFNRIIGEGGYGRVYRGIVQDGVEVAVKLLTGKHQNRDREFIA------E 197 +ELE ATD +S + +G+GG+G VYRG + ++VA+K++ + N D++ + E Sbjct: 204 AELENATDGWSPDNRLGQGGFGDVYRGKWKQ-LDVAIKVMNYRSPNIDQKMVELQQSYNE 262 Query: 198 VEMLSRLHHRNLVKMIGICIERRTRCLVFELVPNGSVESHL--HGSDKIYGPLDFDTRMK 371 ++ L+ + H N++ + G I+ CLV++L+ GS+E+ L H + L + R Sbjct: 263 LKYLNSIRHDNILALYGYSIKGGKPCLVYQLMKGGSLEARLRAHKAQNPLPALTWQQRFS 322 Query: 372 IALGAARGLAYLHEDANPHVIHRDFRLA 455 I+LG ARG+ +LH +IH D + A Sbjct: 323 ISLGTARGIYFLHTARGTPLIHGDIKPA 350
>YR831_MIMIV (Q7T6Y2) Putative serine/threonine-protein kinase/receptor R831| precursor (EC 2.7.11.1) Length = 1624 Score = 79.7 bits (195), Expect = 3e-15 Identities = 50/135 (37%), Positives = 75/135 (55%), Gaps = 2/135 (1%) Frame = +3 Query: 57 DKFSFNRIIGEGGYGRVYRGIVQDGVEVAVKLLTGKHQNRDR--EFIAEVEMLSRLHHRN 230 D+ S + IG G YG V+ G + GV+VAVK + + + EF AE+ LS L H N Sbjct: 1362 DEISIGKQIGLGSYGIVFNGKWK-GVDVAVKKFVKQKLSETQLLEFRAEMAFLSELKHSN 1420 Query: 231 LVKMIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLH 410 +V IG CI++ C+V E + G++ L D + F ++K+ GAA G+ YLH Sbjct: 1421 IVTFIGACIKKPNICIVTEYMRMGNLRDVLKNPDI---KITFANKLKLLYGAAMGIDYLH 1477 Query: 411 EDANPHVIHRDFRLA 455 +NP ++HRD + A Sbjct: 1478 -SSNPMIVHRDIKPA 1491 Score = 73.9 bits (180), Expect = 2e-13 Identities = 41/125 (32%), Positives = 73/125 (58%), Gaps = 2/125 (1%) Frame = +3 Query: 81 IGEGGYGRVYRGIVQDGVEVAVKLLTGKHQNRD--REFIAEVEMLSRLHHRNLVKMIGIC 254 +G GGYG VY+ I + G EVAVKL++ KH ++D R F EV++++ L H N+V + Sbjct: 792 LGTGGYGEVYKSIWK-GTEVAVKLISSKHVSKDMERSFFEEVKIMTSLRHPNVVLFMAAS 850 Query: 255 IERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVI 434 + C+V E + GS+ L +++ + + ++K+A A++G+ +LH ++ Sbjct: 851 TKSPNMCIVMEFMSLGSLYDLL--GNELIPEIPYALKIKMAYQASKGMHFLHSSG---IV 905 Query: 435 HRDFR 449 HRD + Sbjct: 906 HRDLK 910
>TRK1_LYMST (O76997) Putative neurotrophin receptor LTRK 1 precursor (EC| 2.7.10.1) Length = 794 Score = 74.7 bits (182), Expect = 1e-13 Identities = 55/167 (32%), Positives = 78/167 (46%), Gaps = 20/167 (11%) Frame = +3 Query: 3 TCPPTVKTFSISELEKATDKFSFNRIIGEGGYGRVYRGIVQDGVE------VAVKLLTGK 164 TCP TV+ +I + R+IGEG +GRV+ G ++ VAVK L G Sbjct: 494 TCPKTVRLQTILLM----------RVIGEGAFGRVFLGTCAHLIQKNEFAIVAVKTLKGS 543 Query: 165 -HQNRDREFIAEVEMLSRLHHRNLVKMIGICIERRTRCLVFELVPNGSVESHL--HGSDK 335 + R+F E EML+ + H N+V G+C E ++FE + NG + +L HG D Sbjct: 544 CSDSLKRDFEREAEMLATIEHANIVTFYGVCTESDQWMMIFEFMENGDLNKYLRMHGPDA 603 Query: 336 IY-----------GPLDFDTRMKIALGAARGLAYLHEDANPHVIHRD 443 + G L + MKI L A + YL A H +HRD Sbjct: 604 AFLKDRDSMDSDEGQLTREQLMKIVLQIASAMEYL---ALQHFVHRD 647
>YSK4_HUMAN (Q56UN5) SPS1/STE20-related protein kinase YSK4 (EC 2.7.11.1)| (Regulated in COPD, protein kinase) Length = 1328 Score = 72.4 bits (176), Expect = 5e-13 Identities = 44/130 (33%), Positives = 67/130 (51%), Gaps = 6/130 (4%) Frame = +3 Query: 78 IIGEGGYGRVYRGIVQDGVEVAVKLLTGKHQNR------DREFIAEVEMLSRLHHRNLVK 239 I+G+G YG VY G+ G +AVK + N+ R+ EV++L L H N+V Sbjct: 1066 ILGKGAYGTVYCGLTSQGQLIAVKQVALDTSNKLAAEKEYRKLQEEVDLLKALKHVNIVA 1125 Query: 240 MIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDA 419 +G C++ T + E VP GS+ S ++ +GPL K +G+AYLHE+ Sbjct: 1126 YLGTCLQENTVSIFMEFVPGGSISSIINR----FGPLPEMVFCKYTKQILQGVAYLHENC 1181 Query: 420 NPHVIHRDFR 449 V+HRD + Sbjct: 1182 ---VVHRDIK 1188
>HT1_ARATH (Q2MHE4) Serine/threonine-protein kinase HT1 (EC 2.7.11.1) (High| leaf temperature protein 1) Length = 390 Score = 70.1 bits (170), Expect = 3e-12 Identities = 43/126 (34%), Positives = 72/126 (57%), Gaps = 6/126 (4%) Frame = +3 Query: 90 GGYGRVYRGIVQDGVEVAVKLL---TGKHQNR---DREFIAEVEMLSRLHHRNLVKMIGI 251 G + R+YRGI + VAVK++ T K + R +++F +EV +LSRL H N+V+ I Sbjct: 95 GAHSRIYRGIYKQRA-VAVKMVRIPTHKEETRAKLEQQFKSEVALLSRLFHPNIVQFIAA 153 Query: 252 CIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHV 431 C + C++ E + G++ +L+ + L +T +++AL +RG+ YLH V Sbjct: 154 CKKPPVYCIITEYMSQGNLRMYLNKKEPY--SLSIETVLRLALDISRGMEYLHSQG---V 208 Query: 432 IHRDFR 449 IHRD + Sbjct: 209 IHRDLK 214
>FLK_RAT (P09760) Tyrosine-protein kinase FLK (EC 2.7.10.2) (Fragment)| Length = 323 Score = 69.3 bits (168), Expect = 5e-12 Identities = 42/127 (33%), Positives = 66/127 (51%), Gaps = 1/127 (0%) Frame = +3 Query: 66 SFNRIIGEGGYGRVYRGIVQDGVEVAVKLLTGK-HQNRDREFIAEVEMLSRLHHRNLVKM 242 S ++G+G +G VY+G ++D VAVK Q +F+ E ++L + H N+VK+ Sbjct: 65 SLGELLGKGNFGEVYKGTLKDKTPVAVKTCKEDLPQELKIKFLQEAKILKQYDHPNIVKL 124 Query: 243 IGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDAN 422 IG+C +R+ ++ ELVP G S L K L ++ +L A G+ YL Sbjct: 125 IGVCTQRQPVYIIMELVPGGDFLSFLR---KRKDELKLKQLVRFSLDVAAGMLYLE---G 178 Query: 423 PHVIHRD 443 + IHRD Sbjct: 179 KNCIHRD 185
>NTRK2_CHICK (Q91987) BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (Trk-B) Length = 818 Score = 68.6 bits (166), Expect = 8e-12 Identities = 45/138 (32%), Positives = 67/138 (48%), Gaps = 15/138 (10%) Frame = +3 Query: 75 RIIGEGGYGRVYRGIV------QDGVEVAVKLLTGKHQNRDREFIAEVEMLSRLHHRNLV 236 R +GEG +G+V+ QD + VAVK L N ++F E E+L+ L H ++V Sbjct: 538 RELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIV 597 Query: 237 KMIGICIERRTRCLVFELVPNGSVESHL--HGSDKIY-------GPLDFDTRMKIALGAA 389 K G+C+E +VFE + +G + L HG D + L + IA A Sbjct: 598 KFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNRPAELTQSQMLHIAQQIA 657 Query: 390 RGLAYLHEDANPHVIHRD 443 G+ YL A+ H +HRD Sbjct: 658 AGMVYL---ASQHFVHRD 672
>CTR1_ARATH (Q05609) Serine/threonine-protein kinase CTR1 (EC 2.7.11.1)| Length = 821 Score = 68.6 bits (166), Expect = 8e-12 Identities = 45/125 (36%), Positives = 67/125 (53%), Gaps = 2/125 (1%) Frame = +3 Query: 81 IGEGGYGRVYRGIVQDGVEVAVKLLTGK--HQNRDREFIAEVEMLSRLHHRNLVKMIGIC 254 IG G +G V+R G +VAVK+L + H R EF+ EV ++ RL H N+V +G Sbjct: 557 IGAGSFGTVHRA-EWHGSDVAVKILMEQDFHAERVNEFLREVAIMKRLRHPNIVLFMGAV 615 Query: 255 IERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVI 434 + +V E + GS+ LH S LD R+ +A A+G+ YLH + NP ++ Sbjct: 616 TQPPNLSIVTEYLSRGSLYRLLHKSG-AREQLDERRRLSMAYDVAKGMNYLH-NRNPPIV 673 Query: 435 HRDFR 449 HRD + Sbjct: 674 HRDLK 678
>TMKL1_ARATH (P33543) Putative kinase-like protein TMKL1 precursor| Length = 674 Score = 68.2 bits (165), Expect = 1e-11 Identities = 41/126 (32%), Positives = 65/126 (51%), Gaps = 1/126 (0%) Frame = +3 Query: 75 RIIGEGGYGRVYRGIVQDGVEVAVKLLTGKHQNRDREFIAEVEMLSRLHHRNLVKMIGIC 254 +++ + YG VY+ + DG +A++LL + + L R+ H NLV + Sbjct: 377 QVMEKTSYGTVYKAKLSDGGNIALRLLREGTCKDRSSCLPVIRQLGRIRHENLVPLRAFY 436 Query: 255 IERR-TRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHV 431 +R + L+++ +PN S+ LH S L++ R KIALG ARGLAYLH + Sbjct: 437 QGKRGEKLLIYDYLPNISLHDLLHESKPRKPALNWARRHKIALGIARGLAYLHTGQEVPI 496 Query: 432 IHRDFR 449 IH + R Sbjct: 497 IHGNIR 502
>ITK_HUMAN (Q08881) Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2)| (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT) Length = 620 Score = 67.8 bits (164), Expect = 1e-11 Identities = 40/128 (31%), Positives = 70/128 (54%) Frame = +3 Query: 60 KFSFNRIIGEGGYGRVYRGIVQDGVEVAVKLLTGKHQNRDREFIAEVEMLSRLHHRNLVK 239 + +F + IG G +G V+ G + +VA+K + + + +FI E E++ +L H LV+ Sbjct: 362 ELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEE-DFIEEAEVMMKLSHPKLVQ 420 Query: 240 MIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDA 419 + G+C+E+ CLVFE + +G + +L ++ +T + + L G+AYL E Sbjct: 421 LYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAA---ETLLGMCLDVCEGMAYLEEAC 477 Query: 420 NPHVIHRD 443 VIHRD Sbjct: 478 ---VIHRD 482
>ROS_AVISU (P00529) Tyrosine-protein kinase transforming protein ros (EC| 2.7.10.1) Length = 402 Score = 67.8 bits (164), Expect = 1e-11 Identities = 44/140 (31%), Positives = 71/140 (50%), Gaps = 11/140 (7%) Frame = +3 Query: 57 DKFSFNRIIGEGGYGRVYRG----IVQDGV---EVAVKLLT-GKHQNRDREFIAEVEMLS 212 DK + ++++G G +G VY G I+ DG VAVK L G EF+ E ++S Sbjct: 96 DKLNLHKLLGSGAFGEVYEGTALDILADGSGESRVAVKTLKRGATDQEKSEFLKEAHLMS 155 Query: 213 RLHHRNLVKMIGICIERRTRCLVFELVPNGSVESHLHGS--DKIYGP-LDFDTRMKIALG 383 + H +++K++G+C+ + L+ EL+ G + S+L G+ K P L + I L Sbjct: 156 KFDHPHILKLLGVCLLNEPQYLILELMEGGDLLSYLRGARKQKFQSPLLTLTDLLDICLD 215 Query: 384 AARGLAYLHEDANPHVIHRD 443 +G YL + IHRD Sbjct: 216 ICKGCVYLEK---MRFIHRD 232
>ROS_CHICK (P08941) Proto-oncogene tyrosine-protein kinase ROS precursor (EC| 2.7.10.1) (c-ros-1) Length = 2311 Score = 67.8 bits (164), Expect = 1e-11 Identities = 44/140 (31%), Positives = 71/140 (50%), Gaps = 11/140 (7%) Frame = +3 Query: 57 DKFSFNRIIGEGGYGRVYRG----IVQDGV---EVAVKLLT-GKHQNRDREFIAEVEMLS 212 DK + ++++G G +G VY G I+ DG VAVK L G EF+ E ++S Sbjct: 1959 DKLNLHKLLGSGAFGEVYEGTALDILADGSGESRVAVKTLKRGATDQEKSEFLKEAHLMS 2018 Query: 213 RLHHRNLVKMIGICIERRTRCLVFELVPNGSVESHLHGS--DKIYGP-LDFDTRMKIALG 383 + H +++K++G+C+ + L+ EL+ G + S+L G+ K P L + I L Sbjct: 2019 KFDHPHILKLLGVCLLNEPQYLILELMEGGDLLSYLRGARKQKFQSPLLTLTDLLDICLD 2078 Query: 384 AARGLAYLHEDANPHVIHRD 443 +G YL + IHRD Sbjct: 2079 ICKGCVYLEK---MRFIHRD 2095
>NTRK2_HUMAN (Q16620) BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB) (Trk-B) Length = 822 Score = 67.8 bits (164), Expect = 1e-11 Identities = 45/138 (32%), Positives = 67/138 (48%), Gaps = 15/138 (10%) Frame = +3 Query: 75 RIIGEGGYGRVYRGIV------QDGVEVAVKLLTGKHQNRDREFIAEVEMLSRLHHRNLV 236 R +GEG +G+V+ QD + VAVK L N ++F E E+L+ L H ++V Sbjct: 542 RELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIV 601 Query: 237 KMIGICIERRTRCLVFELVPNGSVESHL--HGSDKIY-------GPLDFDTRMKIALGAA 389 K G+C+E +VFE + +G + L HG D + L + IA A Sbjct: 602 KFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIA 661 Query: 390 RGLAYLHEDANPHVIHRD 443 G+ YL A+ H +HRD Sbjct: 662 AGMVYL---ASQHFVHRD 676
>M3KL4_HUMAN (Q5TCX8) Mitogen-activated protein kinase kinase kinase (EC| 2.7.11.25) (Mixed lineage kinase 4) Length = 1036 Score = 67.8 bits (164), Expect = 1e-11 Identities = 46/155 (29%), Positives = 76/155 (49%), Gaps = 17/155 (10%) Frame = +3 Query: 36 SELEKATDKFSFNRIIGEGGYGRVYRGIVQDGVEVAVKLLTGKHQNRDREFIAEVEMLSR 215 S + A ++ +IG GG+G+VYR Q G EVAVK Q+ +++ A E + R Sbjct: 115 SPVHVAFERLELKELIGAGGFGQVYRATWQ-GQEVAVK---AARQDPEQDAAAAAESVRR 170 Query: 216 -------LHHRNLVKMIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTR--- 365 L H N++++ G+C+++ CLV E G++ L ++ P R Sbjct: 171 EARLFAMLRHPNIIELRGVCLQQPHLCLVLEFARGGALNRALAAANAAPDPRAPGPRRAR 230 Query: 366 -------MKIALGAARGLAYLHEDANPHVIHRDFR 449 + A+ ARG+ YLHE+A ++HRD + Sbjct: 231 RIPPHVLVNWAVQIARGMLYLHEEAFVPILHRDLK 265
>NTRK2_RAT (Q63604) BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B) Length = 821 Score = 67.8 bits (164), Expect = 1e-11 Identities = 45/138 (32%), Positives = 67/138 (48%), Gaps = 15/138 (10%) Frame = +3 Query: 75 RIIGEGGYGRVYRGIV------QDGVEVAVKLLTGKHQNRDREFIAEVEMLSRLHHRNLV 236 R +GEG +G+V+ QD + VAVK L N ++F E E+L+ L H ++V Sbjct: 541 RELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIV 600 Query: 237 KMIGICIERRTRCLVFELVPNGSVESHL--HGSDKIY-------GPLDFDTRMKIALGAA 389 K G+C+E +VFE + +G + L HG D + L + IA A Sbjct: 601 KFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIA 660 Query: 390 RGLAYLHEDANPHVIHRD 443 G+ YL A+ H +HRD Sbjct: 661 AGMVYL---ASQHFVHRD 675
>NTRK2_MOUSE (P15209) BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B) Length = 821 Score = 67.8 bits (164), Expect = 1e-11 Identities = 45/138 (32%), Positives = 67/138 (48%), Gaps = 15/138 (10%) Frame = +3 Query: 75 RIIGEGGYGRVYRGIV------QDGVEVAVKLLTGKHQNRDREFIAEVEMLSRLHHRNLV 236 R +GEG +G+V+ QD + VAVK L N ++F E E+L+ L H ++V Sbjct: 541 RELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIV 600 Query: 237 KMIGICIERRTRCLVFELVPNGSVESHL--HGSDKIY-------GPLDFDTRMKIALGAA 389 K G+C+E +VFE + +G + L HG D + L + IA A Sbjct: 601 KFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIA 660 Query: 390 RGLAYLHEDANPHVIHRD 443 G+ YL A+ H +HRD Sbjct: 661 AGMVYL---ASQHFVHRD 675
>NTRK1_HUMAN (P04629) High affinity nerve growth factor receptor precursor (EC| 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1 transforming tyrosine kinase protein) (p140-TrkA) (Trk-A) Length = 796 Score = 67.4 bits (163), Expect = 2e-11 Identities = 43/138 (31%), Positives = 67/138 (48%), Gaps = 17/138 (12%) Frame = +3 Query: 81 IGEGGYGRVYRGIV------QDGVEVAVKLLTGKHQNRDREFIAEVEMLSRLHHRNLVKM 242 +GEG +G+V+ QD + VAVK L ++ ++F E E+L+ L H+++V+ Sbjct: 516 LGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRF 575 Query: 243 IGICIERRTRCLVFELVPNGSVESHLH-----------GSDKIYGPLDFDTRMKIALGAA 389 G+C E R +VFE + +G + L G D GPL + +A A Sbjct: 576 FGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVA 635 Query: 390 RGLAYLHEDANPHVIHRD 443 G+ YL A H +HRD Sbjct: 636 AGMVYL---AGLHFVHRD 650
>NTRK1_RAT (P35739) High affinity nerve growth factor receptor precursor (EC| 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (p140-TrkA) (Slow nerve growth factor receptor) (Trk-A) Length = 799 Score = 67.0 bits (162), Expect = 2e-11 Identities = 43/138 (31%), Positives = 67/138 (48%), Gaps = 17/138 (12%) Frame = +3 Query: 81 IGEGGYGRVYRGIV------QDGVEVAVKLLTGKHQNRDREFIAEVEMLSRLHHRNLVKM 242 +GEG +G+V+ QD + VAVK L +N ++F E E+L+ L H+++V+ Sbjct: 519 LGEGAFGKVFLAECYNLLNDQDKMLVAVKALKETSENARQDFHREAELLTMLQHQHIVRF 578 Query: 243 IGICIERRTRCLVFELVPNGSVESHLH-----------GSDKIYGPLDFDTRMKIALGAA 389 G+C E +VFE + +G + L G D GPL + +A A Sbjct: 579 FGVCTEGGPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVA 638 Query: 390 RGLAYLHEDANPHVIHRD 443 G+ YL A+ H +HRD Sbjct: 639 AGMVYL---ASLHFVHRD 653
>ITK_MOUSE (Q03526) Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2)| (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK) Length = 625 Score = 67.0 bits (162), Expect = 2e-11 Identities = 39/128 (30%), Positives = 70/128 (54%) Frame = +3 Query: 60 KFSFNRIIGEGGYGRVYRGIVQDGVEVAVKLLTGKHQNRDREFIAEVEMLSRLHHRNLVK 239 + +F + IG G +G V+ G + +VA+K + + + +FI E E++ +L H LV+ Sbjct: 367 ELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIQEGAMSEE-DFIEEAEVMMKLSHPKLVQ 425 Query: 240 MIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDA 419 + G+C+E+ CLVFE + +G + +L ++ +T + + L G+AYL + Sbjct: 426 LYGVCLEQAPICLVFEFMEHGCLSDYLRSQRGLFAA---ETLLGMCLDVCEGMAYLEKAC 482 Query: 420 NPHVIHRD 443 VIHRD Sbjct: 483 ---VIHRD 487
>TNI3K_MOUSE (Q5GIG6) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 833 Score = 66.6 bits (161), Expect = 3e-11 Identities = 42/132 (31%), Positives = 74/132 (56%), Gaps = 4/132 (3%) Frame = +3 Query: 60 KFSFNRIIGEGGYGRVYRGIVQDGVEVAVKLLTGKHQNRDRE---FIAEVEMLSRLHHRN 230 + F+ IIG G +G+VY+G ++ + VA+K + F EV +L +L+H Sbjct: 460 EIEFHEIIGSGSFGKVYKGRCRNKI-VAIKRYRANTYCSKSDVDMFCREVSILCQLNHPC 518 Query: 231 LVKMIGICIERRTR-CLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYL 407 +V+ +G C++ ++ +V + + GS+ S LH +I LD +++ IA+ A+G+ YL Sbjct: 519 VVQFVGACLDDPSQFAIVTQYISGGSLFSLLHEQKRI---LDLQSKLIIAVDVAKGMEYL 575 Query: 408 HEDANPHVIHRD 443 H P +IHRD Sbjct: 576 HSLTQP-IIHRD 586
>TNI3K_PONPY (Q5RF15) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) Length = 617 Score = 66.6 bits (161), Expect = 3e-11 Identities = 42/132 (31%), Positives = 73/132 (55%), Gaps = 4/132 (3%) Frame = +3 Query: 60 KFSFNRIIGEGGYGRVYRGIVQDGVEVAVKLLTGKHQNRDRE---FIAEVEMLSRLHHRN 230 + F+ IIG G +G+VY+G ++ + VA+K + F EV +L +L+H Sbjct: 461 EIEFHEIIGSGSFGKVYKGRCRNKI-VAIKRYRANTYCSKSDVDMFCREVSILCQLNHPC 519 Query: 231 LVKMIGICIERRTR-CLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYL 407 +++ +G C+ ++ +V + + GS+ S LH +I LD +++ IA+ ARG+ YL Sbjct: 520 VIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQKRI---LDLQSKLIIAVDVARGMEYL 576 Query: 408 HEDANPHVIHRD 443 H P +IHRD Sbjct: 577 HNLTQP-IIHRD 587
>TNI3K_RAT (Q7TQP6) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 834 Score = 66.6 bits (161), Expect = 3e-11 Identities = 42/132 (31%), Positives = 74/132 (56%), Gaps = 4/132 (3%) Frame = +3 Query: 60 KFSFNRIIGEGGYGRVYRGIVQDGVEVAVKLLTGKHQNRDRE---FIAEVEMLSRLHHRN 230 + F+ IIG G +G+VY+G ++ + VA+K + F EV +L +L+H Sbjct: 461 EIEFHEIIGSGSFGKVYKGRCRNKI-VAIKRYRANTYCSKSDVDMFCREVSILCQLNHPC 519 Query: 231 LVKMIGICIERRTR-CLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYL 407 +V+ +G C++ ++ +V + + GS+ S LH +I LD +++ IA+ A+G+ YL Sbjct: 520 VVQFVGACLDDPSQFAIVTQYISGGSLFSLLHEQKRI---LDLQSKLIIAVDVAKGMEYL 576 Query: 408 HEDANPHVIHRD 443 H P +IHRD Sbjct: 577 HSLTQP-IIHRD 587
>TXK_HUMAN (P42681) Tyrosine-protein kinase TXK (EC 2.7.10.2)| Length = 527 Score = 66.2 bits (160), Expect = 4e-11 Identities = 40/147 (27%), Positives = 75/147 (51%) Frame = +3 Query: 3 TCPPTVKTFSISELEKATDKFSFNRIIGEGGYGRVYRGIVQDGVEVAVKLLTGKHQNRDR 182 +C P FS + E + +F + IG G +G V+ G + ++VA+K + + + Sbjct: 251 SCLPATAGFSYEKWEIDPSELAFIKEIGSGQFGVVHLGEWRSHIQVAIKAINEGSMSEE- 309 Query: 183 EFIAEVEMLSRLHHRNLVKMIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDT 362 +FI E +++ +L H LV++ G+CI+R+ +V E + NG + ++L + G L + Sbjct: 310 DFIEEAKVMMKLSHSKLVQLYGVCIQRKPLYIVTEFMENGCLLNYLRENK---GKLRKEM 366 Query: 363 RMKIALGAARGLAYLHEDANPHVIHRD 443 + + G+ YL + IHRD Sbjct: 367 LLSVCQDICEGMEYLERNG---YIHRD 390
>M3KSL_DROME (Q95UN8) Mitogen-activated protein kinase kinase kinase (EC| 2.7.11.25) (Mixed lineage kinase) (dMLK) (Protein slipper) Length = 1161 Score = 66.2 bits (160), Expect = 4e-11 Identities = 43/135 (31%), Positives = 68/135 (50%), Gaps = 4/135 (2%) Frame = +3 Query: 57 DKFSFNRIIGEGGYGRVYRGIVQDGVEVAVKLL--TGKH--QNRDREFIAEVEMLSRLHH 224 ++ +IG GG+ +V+RG DG EVA+K+ TG+ Q + E ++ L H Sbjct: 140 NELDIKEVIGSGGFCKVHRGYY-DGEEVAIKIAHQTGEDDMQRMRDNVLQEAKLFWALKH 198 Query: 225 RNLVKMIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAY 404 N+ + G+C+ + CLV E GS+ L G + D + A+ ARG+ Y Sbjct: 199 ENIAALRGVCLNTKL-CLVMEYARGGSLNRILAGK------IPPDVLVNWAIQIARGMNY 251 Query: 405 LHEDANPHVIHRDFR 449 LH +A +IHRD + Sbjct: 252 LHNEAPMSIIHRDLK 266
>FER_HUMAN (P16591) Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2)| (p94-FER) (c-FER) Length = 822 Score = 65.9 bits (159), Expect = 5e-11 Identities = 40/123 (32%), Positives = 66/123 (53%), Gaps = 1/123 (0%) Frame = +3 Query: 78 IIGEGGYGRVYRGIVQDGVEVAVKLLTGK-HQNRDREFIAEVEMLSRLHHRNLVKMIGIC 254 ++G+G +G VY+G ++D VAVK Q +F+ E ++L + H N+VK+IG+C Sbjct: 568 LLGKGNFGEVYKGTLKDKTSVAVKTCKEDLPQELKIKFLQEAKILKQYDHPNIVKLIGVC 627 Query: 255 IERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVI 434 +R+ ++ ELV G + L + L +K +L AA G+ YL + + I Sbjct: 628 TQRQPVYIIMELVSGGDFLTFLR---RKKDELKLKQLVKFSLDAAAGMLYLE---SKNCI 681 Query: 435 HRD 443 HRD Sbjct: 682 HRD 684
>TNI3K_HUMAN (Q59H18) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 936 Score = 65.5 bits (158), Expect = 7e-11 Identities = 41/132 (31%), Positives = 73/132 (55%), Gaps = 4/132 (3%) Frame = +3 Query: 60 KFSFNRIIGEGGYGRVYRGIVQDGVEVAVKLLTGKHQNRDRE---FIAEVEMLSRLHHRN 230 + F+ IIG G +G+VY+G ++ + VA+K + F EV +L +L+H Sbjct: 563 EIEFHEIIGSGSFGKVYKGRCRNKI-VAIKRYRANTYCSKSDVDMFCREVSILCQLNHPC 621 Query: 231 LVKMIGICIERRTR-CLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYL 407 +++ +G C+ ++ +V + + GS+ S LH +I LD +++ IA+ A+G+ YL Sbjct: 622 VIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQKRI---LDLQSKLIIAVDVAKGMEYL 678 Query: 408 HEDANPHVIHRD 443 H P +IHRD Sbjct: 679 HNLTQP-IIHRD 689
>M3K9_HUMAN (P80192) Mitogen-activated protein kinase kinase kinase 9 (EC| 2.7.11.25) (Mixed lineage kinase 1) Length = 1104 Score = 65.1 bits (157), Expect = 9e-11 Identities = 46/153 (30%), Positives = 71/153 (46%), Gaps = 4/153 (2%) Frame = +3 Query: 3 TCPPTVKTFSISELEKATDKFSFNRIIGEGGYGRVYRGIVQDGVEVAVKLLTGKHQNRDR 182 +C P ++ I E + IIG GG+G+VYR G EVAVK Sbjct: 129 SCYPPIQLLEIDFAE-----LTLEEIIGIGGFGKVYRAF-WIGDEVAVKAARHDPDEDIS 182 Query: 183 EFIA----EVEMLSRLHHRNLVKMIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPL 350 + I E ++ + L H N++ + G+C++ CLV E G + L G + Sbjct: 183 QTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGK-----RI 237 Query: 351 DFDTRMKIALGAARGLAYLHEDANPHVIHRDFR 449 D + A+ ARG+ YLH++A +IHRD + Sbjct: 238 PPDILVNWAVQIARGMNYLHDEAIVPIIHRDLK 270
>M3K7_DROME (Q9V3Q6) Mitogen-activated protein kinase kinase kinase 7 (EC| 2.7.11.25) (TGF-beta-activated kinase 1) (dTAK1) Length = 678 Score = 64.7 bits (156), Expect = 1e-10 Identities = 48/145 (33%), Positives = 70/145 (48%), Gaps = 3/145 (2%) Frame = +3 Query: 24 TFSISELEKATDKFS---FNRIIGEGGYGRVYRGIVQDGVEVAVKLLTGKHQNRDREFIA 194 T S+ L+ A FS +G G YG V + + +D + VAVK + +D E Sbjct: 3 TASLDALQAAYVDFSEITLREKVGHGSYGVVCKAVWRDKL-VAVKEFFASAEQKDIE--K 59 Query: 195 EVEMLSRLHHRNLVKMIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKI 374 EV+ LSR+ H N++ + GI ++ L+ E GS+ + LHG K+ M Sbjct: 60 EVKQLSRVKHPNIIALHGISSYQQATYLIMEFAEGGSLHNFLHG--KVKPAYSLAHAMSW 117 Query: 375 ALGAARGLAYLHEDANPHVIHRDFR 449 A A GLAYLH +IHRD + Sbjct: 118 ARQCAEGLAYLHAMTPKPLIHRDVK 142
>LTK_MOUSE (P08923) Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1)| Length = 888 Score = 64.7 bits (156), Expect = 1e-10 Identities = 44/144 (30%), Positives = 72/144 (50%), Gaps = 15/144 (10%) Frame = +3 Query: 75 RIIGEGGYGRVYRGIV------QDGVEVAVKLLTGKHQNRDR-EFIAEVEMLSRLHHRNL 233 R +G G +G VY G+V + VA+K L ++D +F+ E ++S+ H+N+ Sbjct: 510 RALGHGAFGEVYEGLVTGLPGDSSPLPVAIKTLPELCSHQDELDFLMEALIISKFSHQNI 569 Query: 234 VKMIGICIERRTRCLVFELVPNGSVESHLHGSDKIYG---PLDFDTRMKIALGAARGLAY 404 V+ +G+ R ++ EL+ G ++S L S G PL +++A A+G Y Sbjct: 570 VRCVGLSFRSAPRLILLELMSGGDMKSFLRHSRPHPGQLAPLTMQDLLQLAQDIAQGCHY 629 Query: 405 LHEDANPHVIHRDFR-----LACS 461 L E+ H IHRD L+CS Sbjct: 630 LEEN---HFIHRDIAARNCLLSCS 650
>M3K7_HUMAN (O43318) Mitogen-activated protein kinase kinase kinase 7 (EC| 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1) Length = 606 Score = 64.7 bits (156), Expect = 1e-10 Identities = 42/127 (33%), Positives = 69/127 (54%), Gaps = 3/127 (2%) Frame = +3 Query: 78 IIGEGGYGRVYRGIVQDGVEVAVKLLTGKHQNRDREFIAEVEMLSRLHHRNLVKMIGICI 257 ++G G +G V + + +VA+K + + + + FI E+ LSR++H N+VK+ G C+ Sbjct: 41 VVGRGAFGVVCKAKWR-AKDVAIKQIESESERK--AFIVELRQLSRVNHPNIVKLYGACL 97 Query: 258 ERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDT---RMKIALGAARGLAYLHEDANPH 428 CLV E GS+ + LHG++ PL + T M L ++G+AYLH Sbjct: 98 --NPVCLVMEYAEGGSLYNVLHGAE----PLPYYTAAHAMSWCLQCSQGVAYLHSMQPKA 151 Query: 429 VIHRDFR 449 +IHRD + Sbjct: 152 LIHRDLK 158
>M3K7_MOUSE (Q62073) Mitogen-activated protein kinase kinase kinase 7 (EC| 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1) Length = 579 Score = 64.7 bits (156), Expect = 1e-10 Identities = 42/127 (33%), Positives = 69/127 (54%), Gaps = 3/127 (2%) Frame = +3 Query: 78 IIGEGGYGRVYRGIVQDGVEVAVKLLTGKHQNRDREFIAEVEMLSRLHHRNLVKMIGICI 257 ++G G +G V + + +VA+K + + + + FI E+ LSR++H N+VK+ G C+ Sbjct: 41 VVGRGAFGVVCKAKWR-AKDVAIKQIESESERK--AFIVELRQLSRVNHPNIVKLYGACL 97 Query: 258 ERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDT---RMKIALGAARGLAYLHEDANPH 428 CLV E GS+ + LHG++ PL + T M L ++G+AYLH Sbjct: 98 --NPVCLVMEYAEGGSLYNVLHGAE----PLPYYTAAHAMSWCLQCSQGVAYLHSMQPKA 151 Query: 429 VIHRDFR 449 +IHRD + Sbjct: 152 LIHRDLK 158
>LTK_HUMAN (P29376) Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1)| (Protein tyrosine kinase 1) Length = 864 Score = 64.7 bits (156), Expect = 1e-10 Identities = 41/133 (30%), Positives = 69/133 (51%), Gaps = 10/133 (7%) Frame = +3 Query: 75 RIIGEGGYGRVYRGIV------QDGVEVAVKLLTGKHQNRDR-EFIAEVEMLSRLHHRNL 233 R +G G +G VY G+V ++VA+K L +D +F+ E ++S+ H+N+ Sbjct: 514 RALGHGAFGEVYEGLVIGLPGDSSPLQVAIKTLPELCSPQDELDFLMEALIISKFRHQNI 573 Query: 234 VKMIGICIERRTRCLVFELVPNGSVESHLHGSDKIYG---PLDFDTRMKIALGAARGLAY 404 V+ +G+ + R ++ EL+ G ++S L S G PL +++A A+G Y Sbjct: 574 VRCVGLSLRATPRLILLELMSGGDMKSFLRHSRPHLGQPSPLVMRDLLQLAQDIAQGCHY 633 Query: 405 LHEDANPHVIHRD 443 L E+ H IHRD Sbjct: 634 LEEN---HFIHRD 643
>ROS_HUMAN (P08922) Proto-oncogene tyrosine-protein kinase ROS precursor (EC| 2.7.10.1) (c-ros-1) Length = 2347 Score = 63.9 bits (154), Expect = 2e-10 Identities = 38/140 (27%), Positives = 72/140 (51%), Gaps = 11/140 (7%) Frame = +3 Query: 57 DKFSFNRIIGEGGYGRVYRGIVQD-------GVEVAVKLLTGKHQNRDR-EFIAEVEMLS 212 +K + ++G G +G VY G D ++VAVK L ++++ EF+ E ++S Sbjct: 1943 EKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMS 2002 Query: 213 RLHHRNLVKMIGICIERRTRCLVFELVPNGSVESHLHGS--DKIYGP-LDFDTRMKIALG 383 + +H N++K +G+C+ + ++ EL+ G + ++L + YGP L + + + Sbjct: 2003 KFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVD 2062 Query: 384 AARGLAYLHEDANPHVIHRD 443 ++G YL H IHRD Sbjct: 2063 ISKGCVYLE---RMHFIHRD 2079
>ROR1_DROME (Q24488) Tyrosine-protein kinase transmembrane receptor Ror| precursor (EC 2.7.10.1) (dRor) Length = 685 Score = 63.5 bits (153), Expect = 2e-10 Identities = 39/130 (30%), Positives = 72/130 (55%), Gaps = 9/130 (6%) Frame = +3 Query: 81 IGEGGYGRVYRGIV----QDGVEVAVKLLTGKHQNR-DREFIAEVEMLSRLHHRNLVKMI 245 +GEG +G+VY+G + + + VA+K L + ++F E+E++S L H+N+V ++ Sbjct: 416 LGEGAFGKVYKGQLLQPNKTTITVAIKALKENASVKTQQDFKREIELISDLKHQNIVCIL 475 Query: 246 GICIERRTRCLVFELVPNGSVESHLHGSD----KIYGPLDFDTRMKIALGAARGLAYLHE 413 G+ + + C++FE + NG + L + K L+F ++IAL + G+ YL Sbjct: 476 GVVLNKEPYCMLFEYMANGDLHEFLISNSPTEGKSLSQLEF---LQIALQISEGMQYL-- 530 Query: 414 DANPHVIHRD 443 + H +HRD Sbjct: 531 -SAHHYVHRD 539
>SRK1_SPOLA (P42686) Tyrosine-protein kinase isoform SRK1 (EC 2.7.10.2)| Length = 505 Score = 62.8 bits (151), Expect = 4e-10 Identities = 42/135 (31%), Positives = 68/135 (50%) Frame = +3 Query: 39 ELEKATDKFSFNRIIGEGGYGRVYRGIVQDGVEVAVKLLTGKHQNRDREFIAEVEMLSRL 218 E+EK K R +G G +G V+ G+ VAVK L + + EF+ E ++ RL Sbjct: 234 EIEKTQIKLL--RRLGAGQFGEVWEGLWNGTTSVAVKTLKPGTMSVE-EFLQEASIMKRL 290 Query: 219 HHRNLVKMIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGL 398 H L+++ +C + +V EL+ GS+ +L G D G L + + +A A G+ Sbjct: 291 RHPKLIQLYAVCTKEEPIYIVTELMKYGSLLEYLRGED---GVLKIEQLVDVAAQVASGM 347 Query: 399 AYLHEDANPHVIHRD 443 +YL + + IHRD Sbjct: 348 SYLEQQ---NYIHRD 359
>SHARK_DROME (Q24145) Tyrosine-protein kinase shark (EC 2.7.10.2)| Length = 939 Score = 62.0 bits (149), Expect = 7e-10 Identities = 50/164 (30%), Positives = 85/164 (51%), Gaps = 18/164 (10%) Frame = +3 Query: 6 CPPTVKTFSISELEKAT-------DKFSFNRIIGEGGYGRVYRGIV--------QDGVEV 140 C T T S +E+E A +K +R IG G +G V+ G + + +EV Sbjct: 636 CSGTPSTPSATEVEAAKLRFFIEPEKLVLDREIGHGEFGSVHSGWLLRKSGAGEESRLEV 695 Query: 141 AVKLLTGKHQNRDREFIAEVEMLSRLHHRNLVKMIGICIERRTRCLVFELVPNGSVESHL 320 A+K+L+ +H N+ +EF+ E ++ RL H+ +V++IGI + +V EL P GS+ ++ Sbjct: 696 AIKMLSDEHSNK-QEFLREASVMMRLEHKCIVRLIGIA-KGEMLMMVQELAPLGSMLQYI 753 Query: 321 --HGSDKIYGPLDFDTRMKI-ALGAARGLAYLHEDANPHVIHRD 443 HG + + + +K+ A A G+ YL + H +HRD Sbjct: 754 LDHGHE-----ITANAELKVWASQIACGMHYLE---SQHFVHRD 789
>TXK_MOUSE (P42682) Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18)| (Resting lymphocyte kinase) Length = 527 Score = 62.0 bits (149), Expect = 7e-10 Identities = 40/147 (27%), Positives = 72/147 (48%) Frame = +3 Query: 3 TCPPTVKTFSISELEKATDKFSFNRIIGEGGYGRVYRGIVQDGVEVAVKLLTGKHQNRDR 182 +C P FS + E + +F + IG G +G V+ G + + VA+K + + + Sbjct: 251 SCLPATSGFSYEKWEIDPSELAFVKEIGSGQFGVVHLGEWRAHIPVAIKAINEGSMSEE- 309 Query: 183 EFIAEVEMLSRLHHRNLVKMIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDT 362 +FI E +++ +L H LV++ G+CI+++ +V E + NG + +L + G L Sbjct: 310 DFIEEAKVMMKLSHSRLVQLYGVCIQQKPLYIVTEFMENGCLLDYLR---ERKGQLQKAL 366 Query: 363 RMKIALGAARGLAYLHEDANPHVIHRD 443 + + G+AYL IHRD Sbjct: 367 LLSMCQDICEGMAYLERSC---YIHRD 390
>ALK_HUMAN (Q9UM73) ALK tyrosine kinase receptor precursor (EC 2.7.10.1)| (Anaplastic lymphoma kinase) (CD246 antigen) Length = 1620 Score = 62.0 bits (149), Expect = 7e-10 Identities = 48/155 (30%), Positives = 77/155 (49%), Gaps = 14/155 (9%) Frame = +3 Query: 21 KTFSISELEKATDK-FSFNRIIGEGGYGRVYRGIVQ------DGVEVAVKLLTGKHQNRD 179 KT SIS+L++ K + R +G G +G VY G V ++VAVK L +D Sbjct: 1101 KTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQD 1160 Query: 180 R-EFIAEVEMLSRLHHRNLVKMIGICIERRTRCLVFELVPNGSVESHLH------GSDKI 338 +F+ E ++S+ +H+N+V+ IG+ ++ R ++ EL+ G ++S L Sbjct: 1161 ELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSS 1220 Query: 339 YGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRD 443 LD + +A A G YL E+ H IHRD Sbjct: 1221 LAMLDL---LHVARDIACGCQYLEEN---HFIHRD 1249
>ALK_MOUSE (P97793) ALK tyrosine kinase receptor precursor (EC 2.7.10.1)| (Anaplastic lymphoma kinase) (CD246 antigen) Length = 1621 Score = 61.6 bits (148), Expect = 9e-10 Identities = 48/155 (30%), Positives = 77/155 (49%), Gaps = 14/155 (9%) Frame = +3 Query: 21 KTFSISELEKATDK-FSFNRIIGEGGYGRVYRGIVQ------DGVEVAVKLLTGKHQNRD 179 KT SIS+L++ K + R +G G +G VY G V ++VAVK L +D Sbjct: 1105 KTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQD 1164 Query: 180 R-EFIAEVEMLSRLHHRNLVKMIGICIERRTRCLVFELVPNGSVESHLH------GSDKI 338 +F+ E ++S+ +H+N+V+ IG+ ++ R ++ EL+ G ++S L Sbjct: 1165 ELDFLMEALIISKFNHQNIVRCIGVSLQALPRFILLELMAGGDLKSFLRETRPRPNQPTS 1224 Query: 339 YGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRD 443 LD + +A A G YL E+ H IHRD Sbjct: 1225 LAMLDL---LHVARDIACGCQYLEEN---HFIHRD 1253
>SRK2_SPOLA (P42688) Tyrosine-protein kinase SRK2 (EC 2.7.10.2) (Fragment)| Length = 362 Score = 61.2 bits (147), Expect = 1e-09 Identities = 39/133 (29%), Positives = 66/133 (49%) Frame = +3 Query: 45 EKATDKFSFNRIIGEGGYGRVYRGIVQDGVEVAVKLLTGKHQNRDREFIAEVEMLSRLHH 224 E + D + R +G G +G VY+G+ + VAVK L + F+AE +++ +L H Sbjct: 89 EISRDSITLIRKLGAGQFGEVYQGLWNNSTPVAVKTLKAGTM-QPAAFLAEAQIMKKLRH 147 Query: 225 RNLVKMIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAY 404 L+++ +C + ++ EL+ GS+ +L G G L + +A A G+AY Sbjct: 148 PKLIQLYAVCTQGEPVYIITELMSKGSLLDYLQGE---AGALKLPQLIDMAAQVAAGMAY 204 Query: 405 LHEDANPHVIHRD 443 L + IHRD Sbjct: 205 LELH---NYIHRD 214
>NTRK1_CHICK (Q91009) High affinity nerve growth factor receptor precursor (EC| 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (Trk-A) (Fragment) Length = 778 Score = 61.2 bits (147), Expect = 1e-09 Identities = 46/138 (33%), Positives = 67/138 (48%), Gaps = 17/138 (12%) Frame = +3 Query: 81 IGEGGYGRVYRGIV------QDGVEVAVKLLTGKHQNRDREFIAEVEMLSRLHHRNLVKM 242 +GEG +G+V+ Q+ VAVK L +N +F E E+L+ L H ++VK Sbjct: 499 LGEGAFGKVFLAECSHLLPEQEKTLVAVKALKEVTENARLDFQREAELLTVLQHEHIVKF 558 Query: 243 IGICIERRTRCLVFELVPNGSVESHL--HGSD-KIY--------GPLDFDTRMKIALGAA 389 G+C E +VFE + +G + L HG D KI G L ++IA A Sbjct: 559 YGVCTEGDPLIMVFEYMKHGDLNRFLRSHGPDAKILDQGQGQPCGQLTLSHMLQIATQIA 618 Query: 390 RGLAYLHEDANPHVIHRD 443 G+ YL A+ H +HRD Sbjct: 619 SGMVYL---ASLHFVHRD 633
>TESK1_HUMAN (Q15569) Dual specificity testis-specific protein kinase 1 (EC| 2.7.12.1) (Testicular protein kinase 1) Length = 626 Score = 61.2 bits (147), Expect = 1e-09 Identities = 41/138 (29%), Positives = 69/138 (50%) Frame = +3 Query: 30 SISELEKATDKFSFNRIIGEGGYGRVYRGIVQDGVEVAVKLLTGKHQNRDREFIAEVEML 209 ++S L + D F IG G + VY+ + +V V + NR + EV+++ Sbjct: 47 AVSSLARVDD-FHCAEKIGAGFFSEVYKVRHRQSGQVMVLKMNKLPSNRGNT-LREVQLM 104 Query: 210 SRLHHRNLVKMIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAA 389 +RL H N+++ +G+C+ + + E + G++E L + PL + R+ +AL A Sbjct: 105 NRLRHPNILRFMGVCVHQGQLHALTEYMNGGTLEQLLSSPE----PLSWPVRLHLALDIA 160 Query: 390 RGLAYLHEDANPHVIHRD 443 RGL YLH V HRD Sbjct: 161 RGLRYLHSKG---VFHRD 175
>LIMK1_DROME (Q8IR79) LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (dLIMK)| Length = 1257 Score = 60.8 bits (146), Expect = 2e-09 Identities = 39/122 (31%), Positives = 68/122 (55%), Gaps = 1/122 (0%) Frame = +3 Query: 81 IGEGGYGRVYRGIVQDGVEVAV-KLLTGKHQNRDREFIAEVEMLSRLHHRNLVKMIGICI 257 +GEG +G+V++ + EV V K L + R FI EV +L L HR+++K IG+ Sbjct: 407 LGEGFFGKVFKVTHRQSGEVMVLKELHRADEEAQRNFIKEVAVLRLLDHRHVLKFIGVLY 466 Query: 258 ERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIH 437 + + +V E V G ++ +H ++ L + R+++A A G++YLH + ++IH Sbjct: 467 KDKKLHMVTEYVAGGCLKELIHDPAQV---LPWPQRVRLARDIACGMSYLH---SMNIIH 520 Query: 438 RD 443 RD Sbjct: 521 RD 522
>MLTK_HUMAN (Q9NYL2) Mitogen-activated protein kinase kinase kinase MLT (EC| 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper-and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase Length = 800 Score = 60.8 bits (146), Expect = 2e-09 Identities = 46/133 (34%), Positives = 65/133 (48%), Gaps = 2/133 (1%) Frame = +3 Query: 57 DKFSFNRIIGEGGYGRVYRG--IVQDGVEVAVKLLTGKHQNRDREFIAEVEMLSRLHHRN 230 D F G G +G VYR I QD EVAVK L + E E+LS L HRN Sbjct: 14 DDLQFFENCGGGSFGSVYRAKWISQDK-EVAVKKLL--------KIEKEAEILSVLSHRN 64 Query: 231 LVKMIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLH 410 +++ G+ +E +V E GS+ +++ + +D D M A A+G+ YLH Sbjct: 65 IIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRS--EEMDMDHIMTWATDVAKGMHYLH 122 Query: 411 EDANPHVIHRDFR 449 +A VIHRD + Sbjct: 123 MEAPVKVIHRDLK 135
>SPK1_DUGTI (P42687) Tyrosine-protein kinase SPK-1 (EC 2.7.10.2)| Length = 497 Score = 60.5 bits (145), Expect = 2e-09 Identities = 38/125 (30%), Positives = 66/125 (52%), Gaps = 2/125 (1%) Frame = +3 Query: 81 IGEGGYGRVYRGIVQDGVEVAVKLLTGKHQNRDREFIAEVEMLSRLHHRNLVKMIGICIE 260 IG G +G V+R EVA K+L R++ F+ E +++ +L HR +V+++G+C E Sbjct: 226 IGRGFFGSVHRAKWGRSYEVAAKMLQSSKAEREK-FVLEAKIMHKLRHRKIVELLGVCTE 284 Query: 261 RR--TRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVI 434 + ++ E + NGS++ +L D L+ M + + G+AYL + V+ Sbjct: 285 PQDMPMLIIVEYMKNGSLKEYLKTPDGKKTNLNQMVHMMAEI--SEGMAYLESE---KVV 339 Query: 435 HRDFR 449 HRD R Sbjct: 340 HRDLR 344
>NTRK3_SAIBB (Q5IS82) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) Length = 825 Score = 60.1 bits (144), Expect = 3e-09 Identities = 43/141 (30%), Positives = 66/141 (46%), Gaps = 18/141 (12%) Frame = +3 Query: 75 RIIGEGGYGRVYRGI------VQDGVEVAVKLLTGKHQNRDREFIAEVEMLSRLHHRNLV 236 R +GEG +G+V+ +D + VAVK L ++F E E+L+ L H ++V Sbjct: 542 RELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIV 601 Query: 237 KMIGICIERRTRCLVFELVPNGSVESHL--HGSDKIY----------GPLDFDTRMKIAL 380 K G+C + +VFE + +G + L HG D + G L + IA Sbjct: 602 KFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPXQAKGELGLSQMLHIAS 661 Query: 381 GAARGLAYLHEDANPHVIHRD 443 A G+ YL A+ H +HRD Sbjct: 662 QIASGMVYL---ASQHFVHRD 679
>NTRK3_PANTR (Q5IS37) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) Length = 825 Score = 60.1 bits (144), Expect = 3e-09 Identities = 43/141 (30%), Positives = 66/141 (46%), Gaps = 18/141 (12%) Frame = +3 Query: 75 RIIGEGGYGRVYRGI------VQDGVEVAVKLLTGKHQNRDREFIAEVEMLSRLHHRNLV 236 R +GEG +G+V+ +D + VAVK L ++F E E+L+ L H ++V Sbjct: 542 RELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIV 601 Query: 237 KMIGICIERRTRCLVFELVPNGSVESHL--HGSDKIY----------GPLDFDTRMKIAL 380 K G+C + +VFE + +G + L HG D + G L + IA Sbjct: 602 KFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIAS 661 Query: 381 GAARGLAYLHEDANPHVIHRD 443 A G+ YL A+ H +HRD Sbjct: 662 QIASGMVYL---ASQHFVHRD 679
>NTRK3_MACFA (Q5IFJ9) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) Length = 825 Score = 60.1 bits (144), Expect = 3e-09 Identities = 43/141 (30%), Positives = 66/141 (46%), Gaps = 18/141 (12%) Frame = +3 Query: 75 RIIGEGGYGRVYRGI------VQDGVEVAVKLLTGKHQNRDREFIAEVEMLSRLHHRNLV 236 R +GEG +G+V+ +D + VAVK L ++F E E+L+ L H ++V Sbjct: 542 RELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIV 601 Query: 237 KMIGICIERRTRCLVFELVPNGSVESHL--HGSDKIY----------GPLDFDTRMKIAL 380 K G+C + +VFE + +G + L HG D + G L + IA Sbjct: 602 KFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIAS 661 Query: 381 GAARGLAYLHEDANPHVIHRD 443 A G+ YL A+ H +HRD Sbjct: 662 QIASGMVYL---ASQHFVHRD 679
>TESK1_RAT (Q63572) Dual specificity testis-specific protein kinase 1 (EC| 2.7.12.1) (Testicular protein kinase 1) Length = 628 Score = 60.1 bits (144), Expect = 3e-09 Identities = 40/138 (28%), Positives = 69/138 (50%) Frame = +3 Query: 30 SISELEKATDKFSFNRIIGEGGYGRVYRGIVQDGVEVAVKLLTGKHQNRDREFIAEVEML 209 ++S L + D F IG G + VY+ + +V V + NR + EV+++ Sbjct: 42 AVSSLARVDD-FDCAEKIGAGFFSEVYKVRHRQSGQVMVLKMNKLPSNRSNT-LREVQLM 99 Query: 210 SRLHHRNLVKMIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAA 389 +RL H N+++ +G+C+ + + E + G++E L + PL + R+ +AL A Sbjct: 100 NRLRHPNILRFMGVCVHQGQLHALTEYMNGGTLEQLLSSPE----PLSWPVRLHLALDIA 155 Query: 390 RGLAYLHEDANPHVIHRD 443 +GL YLH V HRD Sbjct: 156 QGLRYLHAKG---VFHRD 170
>7LESS_DROVI (P20806) Protein sevenless (EC 2.7.10.1)| Length = 2594 Score = 60.1 bits (144), Expect = 3e-09 Identities = 42/143 (29%), Positives = 69/143 (48%), Gaps = 9/143 (6%) Frame = +3 Query: 57 DKFSFNRIIGEGGYGRVYRGIVQDGVE-----VAVKLLTGKHQNRDREFIAEVEMLSRLH 221 ++ + R +G G +G VY G +Q E VA+K L K + E + E +++S Sbjct: 2222 NRLTLLRFLGSGAFGEVYEGQLQAEDEAQPQRVAIKSLR-KGASEFAELLQEAQLMSNFK 2280 Query: 222 HRNLVKMIGICIERRTRCLVFELVPNGSVESHLH----GSDKIYGPLDFDTRMKIALGAA 389 H N+V +IGIC + + L+ E + G + S+L S + L + + L A Sbjct: 2281 HENIVCLIGICCDTDSISLIMEHMEAGDLLSYLRAARPSSQEALSKLQLPELLSMCLDVA 2340 Query: 390 RGLAYLHEDANPHVIHRDFRLAC 458 G +Y+ + H +HRD LAC Sbjct: 2341 NGCSYMED---MHFVHRD--LAC 2358
>M3K10_HUMAN (Q02779) Mitogen-activated protein kinase kinase kinase 10 (EC| 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST) Length = 954 Score = 60.1 bits (144), Expect = 3e-09 Identities = 41/134 (30%), Positives = 61/134 (45%), Gaps = 4/134 (2%) Frame = +3 Query: 60 KFSFNRIIGEGGYGRVYRGIVQDGVEVAVKLLTGKHQNRD----REFIAEVEMLSRLHHR 227 + IIG GG+G+VYR + + G EVAVK + + E + L H Sbjct: 97 ELQLEEIIGVGGFGKVYRALWR-GEEVAVKAARLDPEKDPAVTAEQVCQEARLFGALQHP 155 Query: 228 NLVKMIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYL 407 N++ + G C+ CLV E G++ L G + + A+ ARG+ YL Sbjct: 156 NIIALRGACLNPPHLCLVMEYARGGALSRVLAGRR-----VPPHVLVNWAVQVARGMNYL 210 Query: 408 HEDANPHVIHRDFR 449 H DA +IHRD + Sbjct: 211 HNDAPVPIIHRDLK 224
>TESK1_MOUSE (O70146) Dual specificity testis-specific protein kinase 1 (EC| 2.7.12.1) (Testicular protein kinase 1) Length = 627 Score = 60.1 bits (144), Expect = 3e-09 Identities = 40/138 (28%), Positives = 69/138 (50%) Frame = +3 Query: 30 SISELEKATDKFSFNRIIGEGGYGRVYRGIVQDGVEVAVKLLTGKHQNRDREFIAEVEML 209 ++S L + D F IG G + VY+ + +V V + NR + EV+++ Sbjct: 42 AVSSLARVDD-FDCAEKIGAGFFSEVYKVRHRQSGQVMVLKMNKLPSNRSNT-LREVQLM 99 Query: 210 SRLHHRNLVKMIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAA 389 +RL H N+++ +G+C+ + + E + G++E L + PL + R+ +AL A Sbjct: 100 NRLRHPNILRFMGVCVHQGQLHALTEYMNGGTLEQLLSSPE----PLSWPVRLHLALDIA 155 Query: 390 RGLAYLHEDANPHVIHRD 443 +GL YLH V HRD Sbjct: 156 QGLRYLHAKG---VFHRD 170
>NTRK3_RAT (Q03351) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C) Length = 864 Score = 60.1 bits (144), Expect = 3e-09 Identities = 43/141 (30%), Positives = 66/141 (46%), Gaps = 18/141 (12%) Frame = +3 Query: 75 RIIGEGGYGRVYRGI------VQDGVEVAVKLLTGKHQNRDREFIAEVEMLSRLHHRNLV 236 R +GEG +G+V+ +D + VAVK L ++F E E+L+ L H ++V Sbjct: 542 RELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIV 601 Query: 237 KMIGICIERRTRCLVFELVPNGSVESHL--HGSDKIY----------GPLDFDTRMKIAL 380 K G+C + +VFE + +G + L HG D + G L + IA Sbjct: 602 KFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIAS 661 Query: 381 GAARGLAYLHEDANPHVIHRD 443 A G+ YL A+ H +HRD Sbjct: 662 QIASGMVYL---ASQHFVHRD 679
>NTRK3_HUMAN (Q16288) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C) Length = 839 Score = 60.1 bits (144), Expect = 3e-09 Identities = 43/141 (30%), Positives = 66/141 (46%), Gaps = 18/141 (12%) Frame = +3 Query: 75 RIIGEGGYGRVYRGI------VQDGVEVAVKLLTGKHQNRDREFIAEVEMLSRLHHRNLV 236 R +GEG +G+V+ +D + VAVK L ++F E E+L+ L H ++V Sbjct: 542 RELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIV 601 Query: 237 KMIGICIERRTRCLVFELVPNGSVESHL--HGSDKIY----------GPLDFDTRMKIAL 380 K G+C + +VFE + +G + L HG D + G L + IA Sbjct: 602 KFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIAS 661 Query: 381 GAARGLAYLHEDANPHVIHRD 443 A G+ YL A+ H +HRD Sbjct: 662 QIASGMVYL---ASQHFVHRD 679
>IGF1R_HUMAN (P08069) Insulin-like growth factor 1 receptor precursor (EC| 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 recepto Length = 1367 Score = 59.7 bits (143), Expect = 4e-09 Identities = 39/148 (26%), Positives = 79/148 (53%), Gaps = 13/148 (8%) Frame = +3 Query: 39 ELEKATDKFSFNRIIGEGGYGRVY----RGIVQDGVE--VAVKLLTGKHQNRDR-EFIAE 197 E E A +K + +R +G+G +G VY +G+V+D E VA+K + R+R EF+ E Sbjct: 991 EWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNE 1050 Query: 198 VEMLSRLHHRNLVKMIGICIERRTRCLVFELVPNGSVESHLHG------SDKIYGPLDFD 359 ++ + ++V+++G+ + + ++ EL+ G ++S+L ++ + P Sbjct: 1051 ASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSLS 1110 Query: 360 TRMKIALGAARGLAYLHEDANPHVIHRD 443 +++A A G+AYL+ + +HRD Sbjct: 1111 KMIQMAGEIADGMAYLNAN---KFVHRD 1135
>IGF1R_RAT (P24062) Insulin-like growth factor 1 receptor precursor (EC| 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain] Length = 1370 Score = 59.7 bits (143), Expect = 4e-09 Identities = 40/148 (27%), Positives = 79/148 (53%), Gaps = 13/148 (8%) Frame = +3 Query: 39 ELEKATDKFSFNRIIGEGGYGRVY----RGIVQDGVE--VAVKLLTGKHQNRDR-EFIAE 197 E E A +K + NR +G+G +G VY +G+V+D E VA+K + R+R EF+ E Sbjct: 992 EWEVAREKITMNRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNE 1051 Query: 198 VEMLSRLHHRNLVKMIGICIERRTRCLVFELVPNGSVESHLHG------SDKIYGPLDFD 359 ++ + ++V+++G+ + + ++ EL+ G ++S+L ++ + P Sbjct: 1052 ASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEVENNLVLIPPSLS 1111 Query: 360 TRMKIALGAARGLAYLHEDANPHVIHRD 443 +++A A G+AYL+ + +HRD Sbjct: 1112 KMIQMAGEIADGMAYLNAN---KFVHRD 1136
>KYK1_DICDI (P18160) Non-receptor tyrosine kinase spore lysis A (EC 2.7.10.2)| (Tyrosine-protein kinase 1) Length = 1584 Score = 59.7 bits (143), Expect = 4e-09 Identities = 47/150 (31%), Positives = 77/150 (51%), Gaps = 5/150 (3%) Frame = +3 Query: 9 PPTVKTFSISELEKATDKFSFNRIIGEGGYGRVYRGIVQDGVEVAVKLLTG---KHQNRD 179 PP + SE E ++ F + IG+G +G V RG ++ +VA+K++ K ++ Sbjct: 1271 PPPPQLPVRSEYEIDFNELEFGQTIGKGFFGEVKRGYWRE-TDVAIKIIYRDQFKTKSSL 1329 Query: 180 REFIAEVEMLSRLHHRNLVKMIGICIE--RRTRCLVFELVPNGSVESHLHGSDKIYGPLD 353 F EV +LS+L H N+V+ +G C C+V E + GS+ L + + Sbjct: 1330 VMFQNEVGILSKLRHPNVVQFLGACTAGGEDHHCIVTEWMGGGSLRQFLTDHFNLL-EQN 1388 Query: 354 FDTRMKIALGAARGLAYLHEDANPHVIHRD 443 R+K+AL A+G+ YLH P ++HRD Sbjct: 1389 PHIRLKLALDIAKGMNYLH-GWTPPILHRD 1417
>NTRK3_CHICK (Q91044) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (Trk-C) Length = 827 Score = 59.7 bits (143), Expect = 4e-09 Identities = 43/141 (30%), Positives = 65/141 (46%), Gaps = 18/141 (12%) Frame = +3 Query: 75 RIIGEGGYGRVYRGI------VQDGVEVAVKLLTGKHQNRDREFIAEVEMLSRLHHRNLV 236 R +GEG +G+V+ D + VAVK L ++F E E+L+ L H ++V Sbjct: 544 RELGEGAFGKVFLAECYNLSPTNDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIV 603 Query: 237 KMIGICIERRTRCLVFELVPNGSVESHL--HGSDKIY----------GPLDFDTRMKIAL 380 K G+C + +VFE + +G + L HG D + G L + IA Sbjct: 604 KFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIAS 663 Query: 381 GAARGLAYLHEDANPHVIHRD 443 A G+ YL A+ H +HRD Sbjct: 664 QIASGMVYL---ASQHFVHRD 681
>IGF1R_BOVIN (Q05688) Insulin-like growth factor 1 receptor precursor (EC| 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain] (F Length = 640 Score = 59.7 bits (143), Expect = 4e-09 Identities = 39/148 (26%), Positives = 79/148 (53%), Gaps = 13/148 (8%) Frame = +3 Query: 39 ELEKATDKFSFNRIIGEGGYGRVY----RGIVQDGVE--VAVKLLTGKHQNRDR-EFIAE 197 E E A +K + +R +G+G +G VY +G+V+D E VA+K + R+R EF+ E Sbjct: 264 EWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNE 323 Query: 198 VEMLSRLHHRNLVKMIGICIERRTRCLVFELVPNGSVESHLHG------SDKIYGPLDFD 359 ++ + ++V+++G+ + + ++ EL+ G ++S+L ++ + P Sbjct: 324 ASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSLS 383 Query: 360 TRMKIALGAARGLAYLHEDANPHVIHRD 443 +++A A G+AYL+ + +HRD Sbjct: 384 KMIQMAGEIADGMAYLNAN---KFVHRD 408
>EPHA2_HUMAN (P29317) Ephrin type-A receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) Length = 976 Score = 59.7 bits (143), Expect = 4e-09 Identities = 34/129 (26%), Positives = 68/129 (52%), Gaps = 6/129 (4%) Frame = +3 Query: 75 RIIGEGGYGRVYRGIVQDG-----VEVAVKLLTGKHQNRDR-EFIAEVEMLSRLHHRNLV 236 ++IG G +G VY+G+++ V VA+K L + + R +F+ E ++ + H N++ Sbjct: 617 KVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQRVDFLGEAGIMGQFSHHNII 676 Query: 237 KMIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHED 416 ++ G+ + + ++ E + NG+++ L D + L ++ G A G+ YL Sbjct: 677 RLEGVISKYKPMMIITEYMENGALDKFLREKDGEFSVLQLVGMLR---GIAAGMKYL--- 730 Query: 417 ANPHVIHRD 443 AN + +HRD Sbjct: 731 ANMNYVHRD 739
>MLTK_MOUSE (Q9ESL4) Mitogen-activated protein kinase kinase kinase MLT (EC| 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper-and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) ( Length = 802 Score = 59.3 bits (142), Expect = 5e-09 Identities = 45/133 (33%), Positives = 65/133 (48%), Gaps = 2/133 (1%) Frame = +3 Query: 57 DKFSFNRIIGEGGYGRVYRG--IVQDGVEVAVKLLTGKHQNRDREFIAEVEMLSRLHHRN 230 D F G G +G VYR I QD EVAVK L + E E+LS L HRN Sbjct: 14 DDLQFFENCGGGSFGSVYRAKWISQDK-EVAVKKLL--------KIEKEAEILSVLSHRN 64 Query: 231 LVKMIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLH 410 +++ G+ +E +V E GS+ +++ + +D + M A A+G+ YLH Sbjct: 65 IIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRS--EEMDMEHIMTWATDVAKGMHYLH 122 Query: 411 EDANPHVIHRDFR 449 +A VIHRD + Sbjct: 123 MEAPVKVIHRDLK 135
>M3K11_HUMAN (Q16584) Mitogen-activated protein kinase kinase kinase 11 (EC| 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline-rich kinase) Length = 847 Score = 59.3 bits (142), Expect = 5e-09 Identities = 47/154 (30%), Positives = 68/154 (44%), Gaps = 7/154 (4%) Frame = +3 Query: 9 PPTVKTFSISELEKATDKFSFNRIIGEGGYGRVYRGIVQDGVEVAVKLLTGKHQNRDREF 188 PP + S EL +IG GG+G+VYRG + G VAVK Q+ D + Sbjct: 106 PPPCEVASFQELR-------LEEVIGIGGFGKVYRGSWR-GELVAVK---AARQDPDEDI 154 Query: 189 IA-------EVEMLSRLHHRNLVKMIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGP 347 E + + L H N++ + +C+E CLV E G + L G Sbjct: 155 SVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGR-----R 209 Query: 348 LDFDTRMKIALGAARGLAYLHEDANPHVIHRDFR 449 + + A+ ARG+ YLH +A VIHRD + Sbjct: 210 VPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLK 243
>KIN31_CAEEL (P34265) Probable tyrosine-protein kinase kin-31 (EC 2.7.10.2)| Length = 437 Score = 59.3 bits (142), Expect = 5e-09 Identities = 43/130 (33%), Positives = 69/130 (53%), Gaps = 9/130 (6%) Frame = +3 Query: 81 IGEGGYGRVYRGIVQDG-----VEVAVKLLT----GKHQNRDREFIAEVEMLSRLHHRNL 233 +GEG +G V G+++ V+VAVK + GK Q +D F+ E + L H N+ Sbjct: 136 LGEGAFGEVSSGVMKFKRGGRLVKVAVKQVKTDGIGKDQIKD--FLMEARTMRNLGHPNI 193 Query: 234 VKMIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHE 413 V+ +GI + + LV EL G+++S+L ++ L D R ++ L AA GL Y+H Sbjct: 194 VRFLGIAVLQEPLFLVMELATGGALDSYLKHNEL----LPIDKRHEMLLQAAWGLEYIH- 248 Query: 414 DANPHVIHRD 443 ++HRD Sbjct: 249 --GKPMLHRD 256
>ABL1_CAEEL (P03949) Tyrosine-protein kinase abl-1 (EC 2.7.10.2)| Length = 1224 Score = 59.3 bits (142), Expect = 5e-09 Identities = 41/122 (33%), Positives = 62/122 (50%), Gaps = 1/122 (0%) Frame = +3 Query: 81 IGEGGYGRVYRGI-VQDGVEVAVKLLTGKHQNRDREFIAEVEMLSRLHHRNLVKMIGICI 257 +G G YG VY G + +AVK L EF+AE ++ LHH+NLV+++G+C Sbjct: 317 LGGGQYGDVYEGYWKRHDCTIAVKALKEDAMPL-HEFLAEAAIMKDLHHKNLVRLLGVCT 375 Query: 258 ERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIH 437 ++ E + NG++ +L +DK P +M A A G++YL H IH Sbjct: 376 HEAPFYIITEFMCNGNLLEYLRRTDKSLLPPIILVQM--ASQIASGMSYLEA---RHFIH 430 Query: 438 RD 443 RD Sbjct: 431 RD 432
>IGF1R_MOUSE (Q60751) Insulin-like growth factor 1 receptor precursor (EC| 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain] Length = 1373 Score = 59.3 bits (142), Expect = 5e-09 Identities = 40/149 (26%), Positives = 79/149 (53%), Gaps = 14/149 (9%) Frame = +3 Query: 39 ELEKATDKFSFNRIIGEGGYGRVY----RGIVQDGVE--VAVKLLTGKHQNRDR-EFIAE 197 E E A +K + NR +G+G +G VY +G+V+D E VA+K + R+R EF+ E Sbjct: 992 EWEVAREKITMNRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNE 1051 Query: 198 VEMLSRLHHRNLVKMIGICIERRTRCLVFELVPNGSVESHLHG-------SDKIYGPLDF 356 ++ + ++V+++G+ + + ++ EL+ G ++S+L ++ + P Sbjct: 1052 ASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEVEQNNLVLIPPSL 1111 Query: 357 DTRMKIALGAARGLAYLHEDANPHVIHRD 443 +++A A G+AYL+ + +HRD Sbjct: 1112 SKMIQMAGEIADGMAYLNAN---KFVHRD 1137
>M3LK7_DROME (P83104) Putative mitogen-activated protein kinase kinase kinase| 7-like (EC 2.7.11.25) Length = 393 Score = 58.9 bits (141), Expect = 6e-09 Identities = 39/139 (28%), Positives = 71/139 (51%) Frame = +3 Query: 33 ISELEKATDKFSFNRIIGEGGYGRVYRGIVQDGVEVAVKLLTGKHQNRDREFIAEVEMLS 212 + +++ A K S + +G G G V + Q+ E+AVK+ + + E+ LS Sbjct: 2 VKQVDFAEVKLS-EKFLGAGSGGAVRKATFQNQ-EIAVKIFDFLEETIKKNAEREITHLS 59 Query: 213 RLHHRNLVKMIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAAR 392 + H N++++IG + L+ E + GS+ ++L+G DK + ++ AL A+ Sbjct: 60 EIDHENVIRVIGRASNGKKDYLLMEYLEEGSLHNYLYGDDK--WEYTVEQAVRWALQCAK 117 Query: 393 GLAYLHEDANPHVIHRDFR 449 LAYLH P ++HRD + Sbjct: 118 ALAYLHSLDRP-IVHRDIK 135
>FPS_DROME (P18106) Tyrosine-protein kinase Fps85D (EC 2.7.10.2) (dFer)| Length = 1325 Score = 58.9 bits (141), Expect = 6e-09 Identities = 48/154 (31%), Positives = 77/154 (50%), Gaps = 9/154 (5%) Frame = +3 Query: 9 PPTVKTFSI-------SELEKATDKFSFNRIIGEGGYGRVYRGIVQDG-VEVAVKLLTGK 164 P TVK+ +I E + D IG G +G VY+ ++ ++VAVK Sbjct: 1038 PVTVKSGAILRRPVCRERWELSNDDVVLLERIGRGNFGDVYKAKLKSTKLDVAVKTCRMT 1097 Query: 165 -HQNRDREFIAEVEMLSRLHHRNLVKMIGICIERRTRCLVFELVPNGSVESHLHGSDKIY 341 + R+F+ E +L + H N+VK+IGIC++++ +V ELV GS+ ++L K Sbjct: 1098 LPDEQKRKFLQEGRILKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLR---KNS 1154 Query: 342 GPLDFDTRMKIALGAARGLAYLHEDANPHVIHRD 443 L +M + AA G+ YL + + IHRD Sbjct: 1155 NGLTTRQQMGMCRDAAAGMRYLE---SKNCIHRD 1185
>SRC42_DROME (Q9V9J3) Tyrosine-protein kinase Src42A (EC 2.7.10.2) (Dsrc41)| Length = 517 Score = 58.9 bits (141), Expect = 6e-09 Identities = 37/135 (27%), Positives = 70/135 (51%) Frame = +3 Query: 39 ELEKATDKFSFNRIIGEGGYGRVYRGIVQDGVEVAVKLLTGKHQNRDREFIAEVEMLSRL 218 E+++ + KF R +G G +G V+ G+ + VA+K L + ++F+AE +++ +L Sbjct: 242 EIDRTSLKFV--RKLGSGQFGDVWEGLWNNTTPVAIKTLKSGTMD-PKDFLAEAQIMKKL 298 Query: 219 HHRNLVKMIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGL 398 H L+++ +C ++ EL+ +GS+ +L L T + +A A G+ Sbjct: 299 RHTKLIQLYAVCTVEEPIYIITELMKHGSLLEYLQAIAGKGRSLKMQTLIDMAAQIAAGM 358 Query: 399 AYLHEDANPHVIHRD 443 AYL + + IHRD Sbjct: 359 AYLE---SQNYIHRD 370
>ZYG1_CAEBR (Q621J7) Probable serine/threonine-protein kinase zyg-1 (EC| 2.7.11.1) (Zygote defective protein 1) Length = 709 Score = 58.2 bits (139), Expect = 1e-08 Identities = 39/122 (31%), Positives = 63/122 (51%), Gaps = 1/122 (0%) Frame = +3 Query: 81 IGEGGYGRVYRGIVQDGVEVAVKLL-TGKHQNRDREFIAEVEMLSRLHHRNLVKMIGICI 257 IG+GG+G VY ++G +VA+K + Q R +E E++ + L HRN+V+ Sbjct: 19 IGQGGFGVVYSAQRENGEKVAIKKIGNAASQTRIKE---EIKTMKLLRHRNIVQFYETFF 75 Query: 258 ERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIH 437 E LV EL GS+ ++ K GPLD T + I + Y+H++ +++H Sbjct: 76 ENGETYLVMELCEGGSLMDYV----KQKGPLDDSTAVHILRQLIAAVKYIHDE---NILH 128 Query: 438 RD 443 RD Sbjct: 129 RD 130
>BTKL_DROME (P08630) Tyrosine-protein kinase Btk29A (EC 2.7.10.2) (Dsrc28C)| Length = 786 Score = 58.2 bits (139), Expect = 1e-08 Identities = 35/122 (28%), Positives = 69/122 (56%), Gaps = 1/122 (0%) Frame = +3 Query: 81 IGEGGYGRVYRGIVQDGVEVAVKLLTGKHQNRDREFIAEVEMLSRLHHRNLVKMIGICIE 260 +G G +G V RG + ++ AVK++ + D +FI E +++++L H NLV++ G+C + Sbjct: 532 LGSGQFGVVRRGKWRGSIDTAVKMMKEGTMSED-DFIEEAKVMTKLQHPNLVQLYGVCSK 590 Query: 261 RRTRCLVFELVPNGSVESHLHGSDK-IYGPLDFDTRMKIALGAARGLAYLHEDANPHVIH 437 R +V E + +GS+ ++L +K + G + + + + ++G+ YL + IH Sbjct: 591 HRPIYIVTEYMKHGSLLNYLRRHEKTLIG--NMGLLLDMCIQVSKGMTYLERH---NYIH 645 Query: 438 RD 443 RD Sbjct: 646 RD 647
>KYK2_DICDI (P18161) Tyrosine-protein kinase 2 (EC 2.7.10.2) (Fragment)| Length = 410 Score = 58.2 bits (139), Expect = 1e-08 Identities = 40/129 (31%), Positives = 66/129 (51%), Gaps = 4/129 (3%) Frame = +3 Query: 69 FNRIIGEGGYGRVYRGIVQDGVEVAVKLLT--GKHQNRDREFIAEVEMLSRLHHRNLVKM 242 F + +GEG + V+ G + G+ VA+K L G + FI EV+ L + +H+N+V Sbjct: 110 FIQKVGEGAFSEVWEGWWK-GIHVAIKKLKIIGDEEQFKERFIREVQNLKKGNHQNIVMF 168 Query: 243 IGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPL--DFDTRMKIALGAARGLAYLHED 416 IG C + C++ E + GS+ + LH + + F +K+A A GL +LH Sbjct: 169 IGACY--KPACIITEYMAGGSLYNILHNPNSSTPKVKYSFPLVLKMATDMALGLLHLHSI 226 Query: 417 ANPHVIHRD 443 ++HRD Sbjct: 227 T---IVHRD 232
>IRAK2_HUMAN (O43187) Interleukin-1 receptor-associated kinase-like 2 (IRAK-2)| Length = 590 Score = 58.2 bits (139), Expect = 1e-08 Identities = 39/131 (29%), Positives = 65/131 (49%), Gaps = 3/131 (2%) Frame = +3 Query: 27 FSISELEKATDKFSFNRIIGEGGYGRVYRGIVQDGVEVAVKL---LTGKHQNRDREFIAE 197 +S +++ +ATD F+ NR I +G + VYRG V KL + +R F AE Sbjct: 198 WSEADVVQATDDFNQNRKISQGTFADVYRGHRHGKPFVFKKLRETACSSPGSIERFFQAE 257 Query: 198 VEMLSRLHHRNLVKMIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIA 377 +++ R H N++ ++G C R+ ++ + NGS++ L G PL + R+ I Sbjct: 258 LQICLRCCHPNVLPVLGFCAARQFHSFIYPYMANGSLQDRLQGQGG-SDPLPWPQRVSIC 316 Query: 378 LGAARGLAYLH 410 G + YLH Sbjct: 317 SGLLCAVEYLH 327
>EPHA2_MOUSE (Q03145) Ephrin type-A receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2) Length = 977 Score = 58.2 bits (139), Expect = 1e-08 Identities = 33/129 (25%), Positives = 67/129 (51%), Gaps = 6/129 (4%) Frame = +3 Query: 75 RIIGEGGYGRVYRGIVQDG-----VEVAVKLLTGKHQNRDR-EFIAEVEMLSRLHHRNLV 236 ++IG G +G VY+G ++ + VA+K L + + R +F++E ++ + H N++ Sbjct: 618 KVIGAGEFGEVYKGTLKASSGKKEIPVAIKTLKAGYTEKQRVDFLSEASIMGQFSHHNII 677 Query: 237 KMIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHED 416 + G+ + + ++ E + NG+++ L D + L ++ G A G+ YL Sbjct: 678 PLEGVVSKYKPMMIITEYMENGALDKFLREKDGEFSVLQLVGMLR---GIASGMKYL--- 731 Query: 417 ANPHVIHRD 443 AN + +HRD Sbjct: 732 ANMNYVHRD 740
>EPB1B_XENLA (Q91736) Ephrin type-B receptor 1-B (EC 2.7.10.1) (Tyrosine-protein| kinase receptor XELK) (Fragment) Length = 902 Score = 58.2 bits (139), Expect = 1e-08 Identities = 35/127 (27%), Positives = 68/127 (53%), Gaps = 5/127 (3%) Frame = +3 Query: 78 IIGEGGYGRVYRGIVQ----DGVEVAVKLL-TGKHQNRDREFIAEVEMLSRLHHRNLVKM 242 +IG G +G VY+G ++ + VA+K L G + + R+F++E ++ + H N++++ Sbjct: 542 VIGAGEFGEVYKGRLKLPSKREISVAIKTLKAGYSEKQRRDFLSEASIMGQFDHPNIIRL 601 Query: 243 IGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDAN 422 G+ + R ++ E + NG+++S L +D G + + G A G+ YL E Sbjct: 602 EGVVTKSRPVMIITEFMENGALDSFLRQND---GQFTVIQLVGMLRGIAAGMKYLSE--- 655 Query: 423 PHVIHRD 443 + +HRD Sbjct: 656 MNYVHRD 662
>FAK2_MOUSE (Q9QVP9) Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal| adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinas Length = 1009 Score = 58.2 bits (139), Expect = 1e-08 Identities = 41/136 (30%), Positives = 71/136 (52%), Gaps = 5/136 (3%) Frame = +3 Query: 51 ATDKFSFNRIIGEGGYGRVYRGIVQD--GVEVAVKLLTGKH---QNRDREFIAEVEMLSR 215 A ++ NRI+GEG +G VY G+ + G ++ V + T K Q+ +F++E ++ Sbjct: 421 AREEVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTQDNKEKFMSEAVIMKN 480 Query: 216 LHHRNLVKMIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARG 395 L H ++VK+IGI IE ++ EL P G + +L ++ L T + L + Sbjct: 481 LDHPHIVKLIGI-IEEEPTWIIMELYPYGELGHYL---ERNKNSLKVPTLVLYTLQICKA 536 Query: 396 LAYLHEDANPHVIHRD 443 +AYL + + +HRD Sbjct: 537 MAYLE---SINCVHRD 549
>EPB1A_XENLA (Q91571) Ephrin type-B receptor 1-A precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor XEK) Length = 985 Score = 58.2 bits (139), Expect = 1e-08 Identities = 35/127 (27%), Positives = 68/127 (53%), Gaps = 5/127 (3%) Frame = +3 Query: 78 IIGEGGYGRVYRGIVQ----DGVEVAVKLL-TGKHQNRDREFIAEVEMLSRLHHRNLVKM 242 +IG G +G VY+G ++ + VA+K L G + + R+F++E ++ + H N++++ Sbjct: 625 VIGAGEFGEVYKGRLKLPSKREISVAIKTLKAGYSEKQRRDFLSEASIMGQFDHPNIIRL 684 Query: 243 IGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDAN 422 G+ + R ++ E + NG+++S L +D G + + G A G+ YL E Sbjct: 685 EGVVTKSRPVMIITEFMENGALDSFLRQND---GQFTVIQLVGMLRGIAAGMKYLSE--- 738 Query: 423 PHVIHRD 443 + +HRD Sbjct: 739 MNYVHRD 745
>TIE1_HUMAN (P35590) Tyrosine-protein kinase receptor Tie-1 precursor (EC| 2.7.10.1) Length = 1138 Score = 57.8 bits (138), Expect = 1e-08 Identities = 43/146 (29%), Positives = 72/146 (49%), Gaps = 17/146 (11%) Frame = +3 Query: 57 DKFSFNRIIGEGGYGRVYRGIVQ-DGVEV--AVKLLTG-KHQNRDREFIAEVEMLSRL-H 221 + +F +IGEG +G+V R +++ DG+++ A+K+L +N R+F E+E+L +L H Sbjct: 837 EDITFEDLIGEGNFGQVIRAMIKKDGLKMNAAIKMLKEYASENDHRDFAGELEVLCKLGH 896 Query: 222 HRNLVKMIGICIERRTRCLVFELVPNGSVESHLHGSDKI------------YGPLDFDTR 365 H N++ ++G C R + E P G++ L S + L Sbjct: 897 HPNIINLLGACKNRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTLSSRQL 956 Query: 366 MKIALGAARGLAYLHEDANPHVIHRD 443 ++ A AA G+ YL E IHRD Sbjct: 957 LRFASDAANGMQYLSE---KQFIHRD 979
>TIE1_BOVIN (Q06805) Tyrosine-protein kinase receptor Tie-1 precursor (EC| 2.7.10.1) Length = 1136 Score = 57.8 bits (138), Expect = 1e-08 Identities = 43/146 (29%), Positives = 72/146 (49%), Gaps = 17/146 (11%) Frame = +3 Query: 57 DKFSFNRIIGEGGYGRVYRGIVQ-DGVEV--AVKLLTG-KHQNRDREFIAEVEMLSRL-H 221 + +F +IGEG +G+V R +++ DG+++ A+K+L +N R+F E+E+L +L H Sbjct: 835 EDITFEDLIGEGNFGQVIRAMIKKDGLKMNAAIKMLKEYASENDHRDFAGELEVLCKLGH 894 Query: 222 HRNLVKMIGICIERRTRCLVFELVPNGSVESHLHGSDKI------------YGPLDFDTR 365 H N++ ++G C R + E P G++ L S + L Sbjct: 895 HPNIINLLGACENRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTLSSRQL 954 Query: 366 MKIALGAARGLAYLHEDANPHVIHRD 443 ++ A AA G+ YL E IHRD Sbjct: 955 LRFASDAANGMQYLSE---KQFIHRD 977
>TIE1_MOUSE (Q06806) Tyrosine-protein kinase receptor Tie-1 precursor (EC| 2.7.10.1) Length = 1134 Score = 57.8 bits (138), Expect = 1e-08 Identities = 43/146 (29%), Positives = 72/146 (49%), Gaps = 17/146 (11%) Frame = +3 Query: 57 DKFSFNRIIGEGGYGRVYRGIVQ-DGVEV--AVKLLTG-KHQNRDREFIAEVEMLSRL-H 221 + +F +IGEG +G+V R +++ DG+++ A+K+L +N R+F E+E+L +L H Sbjct: 833 EDITFEDLIGEGNFGQVIRAMIKKDGLKMNAAIKMLKEYASENDHRDFAGELEVLCKLGH 892 Query: 222 HRNLVKMIGICIERRTRCLVFELVPNGSVESHLHGSDKI------------YGPLDFDTR 365 H N++ ++G C R + E P G++ L S + L Sbjct: 893 HPNIINLLGACENRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTLSSRQL 952 Query: 366 MKIALGAARGLAYLHEDANPHVIHRD 443 ++ A AA G+ YL E IHRD Sbjct: 953 LRFASDAANGMQYLSE---KQFIHRD 975
>PTK6_HUMAN (Q13882) Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor| kinase) (Tyrosine-protein kinase BRK) Length = 451 Score = 57.8 bits (138), Expect = 1e-08 Identities = 34/133 (25%), Positives = 71/133 (53%) Frame = +3 Query: 45 EKATDKFSFNRIIGEGGYGRVYRGIVQDGVEVAVKLLTGKHQNRDREFIAEVEMLSRLHH 224 E+ ++F+ R +G G +G V+ G+ +D V+VA+K+++ + + +E++ + +L H Sbjct: 185 ERPREEFTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMKKLRH 244 Query: 225 RNLVKMIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAY 404 ++++ + + ++ EL+ GS+ L SD+ P+ + IA A G+ Y Sbjct: 245 KHILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPV--SELLDIAWQVAEGMCY 302 Query: 405 LHEDANPHVIHRD 443 L + + IHRD Sbjct: 303 LE---SQNYIHRD 312
>SRMS_MOUSE (Q62270) Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70)| Length = 496 Score = 57.8 bits (138), Expect = 1e-08 Identities = 39/135 (28%), Positives = 65/135 (48%) Frame = +3 Query: 39 ELEKATDKFSFNRIIGEGGYGRVYRGIVQDGVEVAVKLLTGKHQNRDREFIAEVEMLSRL 218 E E+ +F R +GEG +G V+ G+ + VAVK++ + + E+E L L Sbjct: 226 EWERPRSEFVLRRKLGEGFFGEVWEGLWLGSIPVAVKVIKSADM-KLADLTKEIEALKSL 284 Query: 219 HHRNLVKMIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGL 398 H L+++ IC +V EL+ G+++ +L S+ L + A A G+ Sbjct: 285 RHERLIRLHAICSLGEPVYIVTELMGKGNLQVYLGSSEG--KALSLPHLLGFACQVAEGM 342 Query: 399 AYLHEDANPHVIHRD 443 +YL E V+HRD Sbjct: 343 SYLEE---RRVVHRD 354
>EPHB1_RAT (P09759) Ephrin type-B receptor 1 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EPH-2) (ELK) Length = 984 Score = 57.4 bits (137), Expect = 2e-08 Identities = 35/127 (27%), Positives = 68/127 (53%), Gaps = 5/127 (3%) Frame = +3 Query: 78 IIGEGGYGRVYRGIVQ----DGVEVAVKLL-TGKHQNRDREFIAEVEMLSRLHHRNLVKM 242 +IG G +G VY+G ++ + VA+K L G + + R+F++E ++ + H N++++ Sbjct: 624 VIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRDFLSEASIMGQFDHPNIIRL 683 Query: 243 IGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDAN 422 G+ + R ++ E + NG+++S L +D G + + G A G+ YL E Sbjct: 684 EGVVTKSRPVMIITEFMENGALDSFLRQND---GQFTVIQLVGMLRGIAAGMKYLSE--- 737 Query: 423 PHVIHRD 443 + +HRD Sbjct: 738 MNYVHRD 744
>EPHB1_HUMAN (P54762) Ephrin type-B receptor 1 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EPH-2) (NET) (HEK6) (ELK) Length = 984 Score = 57.4 bits (137), Expect = 2e-08 Identities = 35/127 (27%), Positives = 68/127 (53%), Gaps = 5/127 (3%) Frame = +3 Query: 78 IIGEGGYGRVYRGIVQ----DGVEVAVKLL-TGKHQNRDREFIAEVEMLSRLHHRNLVKM 242 +IG G +G VY+G ++ + VA+K L G + + R+F++E ++ + H N++++ Sbjct: 624 VIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRDFLSEASIMGQFDHPNIIRL 683 Query: 243 IGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDAN 422 G+ + R ++ E + NG+++S L +D G + + G A G+ YL A Sbjct: 684 EGVVTKSRPVMIITEFMENGALDSFLRQND---GQFTVIQLVGMLRGIAAGMKYL---AE 737 Query: 423 PHVIHRD 443 + +HRD Sbjct: 738 MNYVHRD 744
>EPHB1_CHICK (Q07494) Ephrin type-B receptor 1 (EC 2.7.10.1) (Tyrosine-protein| kinase receptor EPH-2) (Tyrosine kinase CEK6 receptor) (Fragment) Length = 984 Score = 57.4 bits (137), Expect = 2e-08 Identities = 35/127 (27%), Positives = 68/127 (53%), Gaps = 5/127 (3%) Frame = +3 Query: 78 IIGEGGYGRVYRGIVQ----DGVEVAVKLL-TGKHQNRDREFIAEVEMLSRLHHRNLVKM 242 +IG G +G VY+G ++ + VA+K L G + + R+F++E ++ + H N++++ Sbjct: 624 VIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRDFLSEASIMGQFDHPNIIRL 683 Query: 243 IGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDAN 422 G+ + R ++ E + NG+++S L +D G + + G A G+ YL A Sbjct: 684 EGVVTKSRPVMIITEFMENGALDSFLRQND---GQFTVIQLVGMLRGIAAGMKYL---AE 737 Query: 423 PHVIHRD 443 + +HRD Sbjct: 738 MNYVHRD 744
>FPS_AVISP (P00541) Tyrosine-protein kinase transforming protein Fps (EC| 2.7.10.2) Length = 533 Score = 57.4 bits (137), Expect = 2e-08 Identities = 41/124 (33%), Positives = 62/124 (50%), Gaps = 3/124 (2%) Frame = +3 Query: 81 IGEGGYGRVYRGIVQ-DGVEVAVKLLTGK-HQNRDREFIAEVEMLSRLHHRNLVKMIGIC 254 IG G +G V+ G ++ D VAVK +F+ E +L + +H N+V++IG+C Sbjct: 278 IGRGNFGEVFSGRLRADNTPVAVKSCRETLPPELKAKFLQEARILKQYNHPNIVRLIGVC 337 Query: 255 IERRTRCLVFELVPNGSVESHLHGSDKIYGP-LDFDTRMKIALGAARGLAYLHEDANPHV 431 +++ +V ELV G S L GP L +K+ AA G+ YL + H Sbjct: 338 TQKQPIYIVMELVQGGDFLSFLRSK----GPHLKMKELIKMMENAAAGMEYLE---SKHC 390 Query: 432 IHRD 443 IHRD Sbjct: 391 IHRD 394
>FAK2_RAT (P70600) Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal| adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) Length = 1009 Score = 57.4 bits (137), Expect = 2e-08 Identities = 42/136 (30%), Positives = 70/136 (51%), Gaps = 5/136 (3%) Frame = +3 Query: 51 ATDKFSFNRIIGEGGYGRVYRGIVQD--GVEVAVKLLTGKHQ---NRDREFIAEVEMLSR 215 A + NRI+GEG +G VY G+ + G ++ V + T K + +F++E ++ Sbjct: 421 AREDVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKN 480 Query: 216 LHHRNLVKMIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARG 395 L H ++VK+IGI IE +V EL P G + +L ++ L T + AL + Sbjct: 481 LDHPHIVKLIGI-IEEEPTWIVMELYPYGELGHYL---ERNKNSLKVPTLVLYALQICKA 536 Query: 396 LAYLHEDANPHVIHRD 443 +AYL + + +HRD Sbjct: 537 MAYLE---SINCVHRD 549
>FPS_FUJSV (P00530) Tyrosine-protein kinase transforming protein FPS (EC| 2.7.10.2) Length = 873 Score = 57.4 bits (137), Expect = 2e-08 Identities = 41/124 (33%), Positives = 62/124 (50%), Gaps = 3/124 (2%) Frame = +3 Query: 81 IGEGGYGRVYRGIVQ-DGVEVAVKLLTGK-HQNRDREFIAEVEMLSRLHHRNLVKMIGIC 254 IG G +G V+ G ++ D VAVK +F+ E +L + +H N+V++IG+C Sbjct: 618 IGRGNFGEVFSGRLRADNTPVAVKSCRETLPPELKAKFLQEARILKQCNHPNIVRLIGVC 677 Query: 255 IERRTRCLVFELVPNGSVESHLHGSDKIYGP-LDFDTRMKIALGAARGLAYLHEDANPHV 431 +++ +V ELV G S L GP L +K+ AA G+ YL + H Sbjct: 678 TQKQPIYIVMELVQGGDFLSFLRSK----GPRLKMKKLIKMMENAAAGMEYLE---SKHC 730 Query: 432 IHRD 443 IHRD Sbjct: 731 IHRD 734
>CDC7_SCHPO (P41892) Cell division control protein 7 (EC 2.7.11.1)| Length = 1062 Score = 57.0 bits (136), Expect = 2e-08 Identities = 42/126 (33%), Positives = 63/126 (50%), Gaps = 3/126 (2%) Frame = +3 Query: 81 IGEGGYGRVYRGI-VQDGVEVAVKLLT-GKHQNRDREFIA-EVEMLSRLHHRNLVKMIGI 251 +G+G +G VYRG+ +++G VAVK + K D I E+++L L H N+VK G Sbjct: 15 LGKGAFGAVYRGLNIKNGETVAVKKVKLSKMLKSDLSVIKMEIDLLKNLDHPNIVKYRGS 74 Query: 252 CIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHV 431 + C++ E NGS+ S K +G + + +GL YLH N V Sbjct: 75 YQTNDSLCIILEYCENGSLRSIC----KNFGKIPENLVALYTFQVLQGLLYLH---NQGV 127 Query: 432 IHRDFR 449 IHRD + Sbjct: 128 IHRDIK 133
>NTRK3_PIG (P24786) NT-3 growth factor receptor precursor (EC 2.7.10.1)| (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C) Length = 825 Score = 57.0 bits (136), Expect = 2e-08 Identities = 40/141 (28%), Positives = 64/141 (45%), Gaps = 18/141 (12%) Frame = +3 Query: 75 RIIGEGGYGRVYRGIVQDGVEVAVKLLTGKHQNRD------REFIAEVEMLSRLHHRNLV 236 R +GEG +G+V+ + VK+L +D ++F E E+L+ L H ++V Sbjct: 542 RELGEGAFGKVFLAECYNLSPTKVKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIV 601 Query: 237 KMIGICIERRTRCLVFELVPNGSVESHL--HGSDKIY----------GPLDFDTRMKIAL 380 K G+C + +VFE + +G + L HG D + G L + IA Sbjct: 602 KFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIAS 661 Query: 381 GAARGLAYLHEDANPHVIHRD 443 G+ YL A+ H +HRD Sbjct: 662 QICSGMVYL---ASQHFVHRD 679
>STK_HYDAT (P17713) Tyrosine-protein kinase STK (EC 2.7.10.2) (P57-STK)| Length = 509 Score = 57.0 bits (136), Expect = 2e-08 Identities = 37/129 (28%), Positives = 64/129 (49%) Frame = +3 Query: 57 DKFSFNRIIGEGGYGRVYRGIVQDGVEVAVKLLTGKHQNRDREFIAEVEMLSRLHHRNLV 236 + NR +G G +G V+ G+ + +VAVK L + F+ E ++ +L H++LV Sbjct: 238 ESLRLNRKLGAGQFGEVWAGVWNNTTQVAVKTLKPGTMS-PASFLDEAGVMKKLRHKHLV 296 Query: 237 KMIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHED 416 ++ IC +R +V E + GS+ +L + + L T + +A A G+A+L Sbjct: 297 QLYAICSDREPIYIVTEYMSGGSLLDYLSKGEGV--NLQLPTLIDMAAQVASGMAFLEAQ 354 Query: 417 ANPHVIHRD 443 IHRD Sbjct: 355 G---YIHRD 360
>LRRK2_MOUSE (Q5S006) Leucine-rich repeat serine/threonine-protein kinase 2 (EC| 2.7.11.1) Length = 2527 Score = 57.0 bits (136), Expect = 2e-08 Identities = 46/124 (37%), Positives = 67/124 (54%) Frame = +3 Query: 78 IIGEGGYGRVYRGIVQDGVEVAVKLLTGKHQNRDREFIAEVEMLSRLHHRNLVKMIGICI 257 ++G+G +G VYR +G EVAVK+ KH + R E+ +L LHH +L+ ++ I Sbjct: 1884 LLGDGSFGSVYRA-AYEGEEVAVKIFN-KHTSL-RLLRQELVVLCHLHHPSLISLLAAGI 1940 Query: 258 ERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIH 437 R R LV EL GS++ L DK L + +IAL A GL YLH + +I+ Sbjct: 1941 --RPRMLVMELASKGSLDRLLQ-QDK--ASLTRTLQHRIALHVADGLRYLH---SAMIIY 1992 Query: 438 RDFR 449 RD + Sbjct: 1993 RDLK 1996
>LRRK2_HUMAN (Q5S007) Leucine-rich repeat serine/threonine-protein kinase 2 (EC| 2.7.11.1) (Dardarin) Length = 2527 Score = 57.0 bits (136), Expect = 2e-08 Identities = 46/124 (37%), Positives = 67/124 (54%) Frame = +3 Query: 78 IIGEGGYGRVYRGIVQDGVEVAVKLLTGKHQNRDREFIAEVEMLSRLHHRNLVKMIGICI 257 ++G+G +G VYR +G EVAVK+ KH + R E+ +L LHH +L+ ++ I Sbjct: 1884 LLGDGSFGSVYRA-AYEGEEVAVKIFN-KHTSL-RLLRQELVVLCHLHHPSLISLLAAGI 1940 Query: 258 ERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIH 437 R R LV EL GS++ L DK L + +IAL A GL YLH + +I+ Sbjct: 1941 --RPRMLVMELASKGSLDRLLQ-QDK--ASLTRTLQHRIALHVADGLRYLH---SAMIIY 1992 Query: 438 RDFR 449 RD + Sbjct: 1993 RDLK 1996
>PR2_DROME (Q9I7F7) Tyrosine-protein kinase PR2 (EC 2.7.10.2)| Length = 1337 Score = 56.6 bits (135), Expect = 3e-08 Identities = 39/133 (29%), Positives = 65/133 (48%), Gaps = 4/133 (3%) Frame = +3 Query: 57 DKFSFNRIIGEGGYGRVYRGIVQDG---VEVAVKLLTGKH-QNRDREFIAEVEMLSRLHH 224 D S N+ +G G +G V +G+ +G ++VA+K L + Q+ EF+ E ++ + H Sbjct: 131 DSISVNKQLGTGEFGIVQQGVWSNGNERIQVAIKCLCRERMQSNPMEFLKEAAIMHSIEH 190 Query: 225 RNLVKMIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAY 404 N+V++ G+ + + LV EL S+ L S L T + AL G+ Y Sbjct: 191 ENIVRLYGVVLATDSLMLVTELAHLRSLLECLKDSGLRVSFLTIPTLCEFALQICNGMRY 250 Query: 405 LHEDANPHVIHRD 443 L + +IHRD Sbjct: 251 LEQ---KRLIHRD 260
>EPHA3_MOUSE (P29319) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ETK1) (MEK4) Length = 983 Score = 56.2 bits (134), Expect = 4e-08 Identities = 37/147 (25%), Positives = 74/147 (50%), Gaps = 7/147 (4%) Frame = +3 Query: 24 TFSISELEKATD--KFSFNRIIGEGGYGRVYRGIVQ----DGVEVAVKLL-TGKHQNRDR 182 T ++ E K D S ++++G G +G V G ++ + VA+K L G + + R Sbjct: 606 TQAVHEFAKELDATNISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRR 665 Query: 183 EFIAEVEMLSRLHHRNLVKMIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDT 362 +F+ E ++ + H N++++ G+ + + +V E + NGS++S L D + + Sbjct: 666 DFLGEASIMGQFDHPNIIRLEGVVTKSKPEMIVTEYMENGSLDSFLRKHDAQFTVIQLVG 725 Query: 363 RMKIALGAARGLAYLHEDANPHVIHRD 443 ++ G A G+ YL ++ +HRD Sbjct: 726 MLR---GIASGMKYL---SDMGYVHRD 746
>M3K3_ARATH (O22042) Mitogen-activated protein kinase kinase kinase 3 (EC| 2.7.11.25) (Arabidospsis NPK1-related protein kinase 3) Length = 651 Score = 56.2 bits (134), Expect = 4e-08 Identities = 43/133 (32%), Positives = 64/133 (48%), Gaps = 9/133 (6%) Frame = +3 Query: 78 IIGEGGYGRVYRGIVQDGVEV-AVKLLT--------GKHQNRDREFIAEVEMLSRLHHRN 230 +IG G +GRVY G+ D E+ A+K + K Q RE EV++L L H N Sbjct: 73 LIGCGAFGRVYMGMNLDSGELLAIKQVLIAPSSASKEKTQGHIRELEEEVQLLKNLSHPN 132 Query: 231 LVKMIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLH 410 +V+ +G E + ++ E VP GS+ S L P+ ++ L GL YLH Sbjct: 133 IVRYLGTVRESDSLNILMEFVPGGSISSLLEKFGSFPEPVIIMYTKQLLL----GLEYLH 188 Query: 411 EDANPHVIHRDFR 449 N ++HRD + Sbjct: 189 ---NNGIMHRDIK 198
>ERBB4_HUMAN (Q15303) Receptor tyrosine-protein kinase erbB-4 precursor (EC| 2.7.10.1) (p180erbB4) (Tyrosine kinase-type cell surface receptor HER4) Length = 1308 Score = 56.2 bits (134), Expect = 4e-08 Identities = 43/132 (32%), Positives = 76/132 (57%), Gaps = 9/132 (6%) Frame = +3 Query: 75 RIIGEGGYGRVYRGI-VQDG----VEVAVKLL---TGKHQNRDREFIAEVEMLSRLHHRN 230 +++G G +G VY+GI V +G + VA+K+L TG N EF+ E +++ + H + Sbjct: 722 KVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANV--EFMDEALIMASMDHPH 779 Query: 231 LVKMIGICIERRTRCLVFELVPNGSVESHLH-GSDKIYGPLDFDTRMKIALGAARGLAYL 407 LV+++G+C+ T LV +L+P+G + ++H D I L + ++I A+G+ YL Sbjct: 780 LVRLLGVCLS-PTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQI----AKGMMYL 834 Query: 408 HEDANPHVIHRD 443 E ++HRD Sbjct: 835 EE---RRLVHRD 843
>M3K2_ARATH (Q9FZ36) Mitogen-activated protein kinase kinase kinase 2 (EC| 2.7.11.25) (Arabidospsis NPK1-related protein kinase 2) Length = 651 Score = 55.8 bits (133), Expect = 5e-08 Identities = 49/156 (31%), Positives = 71/156 (45%), Gaps = 9/156 (5%) Frame = +3 Query: 9 PPTVKTFSISELEKATDKFSFNRIIGEGGYGRVYRGIVQDGVEV-AVK--LLTG------ 161 PP T I K ++ ++IG G +G VY G+ D E+ AVK L+T Sbjct: 54 PPNNSTVQI----KPPIRWRKGQLIGRGAFGTVYMGMNLDSGELLAVKQVLITSNCASKE 109 Query: 162 KHQNRDREFIAEVEMLSRLHHRNLVKMIGICIERRTRCLVFELVPNGSVESHLHGSDKIY 341 K Q +E EV++L L H N+V+ +G E T ++ E VP GS+ S L + + Sbjct: 110 KTQAHIQELEEEVKLLKNLSHPNIVRYLGTVREDETLNILLEFVPGGSISSLL----EKF 165 Query: 342 GPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFR 449 G GL YLH A ++HRD + Sbjct: 166 GAFPESVVRTYTNQLLLGLEYLHNHA---IMHRDIK 198
>MKH1_SCHPO (Q10407) MAP kinase kinase kinase mkh1 (EC 2.7.11.25)| Length = 1116 Score = 55.8 bits (133), Expect = 5e-08 Identities = 43/158 (27%), Positives = 70/158 (44%), Gaps = 11/158 (6%) Frame = +3 Query: 9 PPTVKTFSISELEKATDKFSFNRIIGEGGYGRVYRGI-VQDGVEVAVK------LLTGKH 167 P T T + AT K+ +IG G YG+V+ + + G +AVK + G+H Sbjct: 807 PDTTITSGSVVSQNATFKWMKGELIGNGTYGKVFLAMNINTGELIAVKQVEIPQTINGRH 866 Query: 168 QNRDREFI----AEVEMLSRLHHRNLVKMIGICIERRTRCLVFELVPNGSVESHLHGSDK 335 ++ + AE+ M++ L H N+V+ +G + E V GS+ L Sbjct: 867 DQLRKDIVDSINAEISMIADLDHLNIVQYLGFEKTETDISIFLEYVSGGSIGRCLRN--- 923 Query: 336 IYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFR 449 YGP + ++ GL+YLH +IHRD + Sbjct: 924 -YGPFEEQLVRFVSRQVLYGLSYLHSKG---IIHRDLK 957
>ERBB4_RAT (Q62956) Receptor tyrosine-protein kinase erbB-4 precursor (EC| 2.7.10.1) Length = 1308 Score = 55.8 bits (133), Expect = 5e-08 Identities = 43/132 (32%), Positives = 76/132 (57%), Gaps = 9/132 (6%) Frame = +3 Query: 75 RIIGEGGYGRVYRGI-VQDG----VEVAVKLL---TGKHQNRDREFIAEVEMLSRLHHRN 230 +++G G +G VY+GI V +G + VA+K+L TG N EF+ E +++ + H + Sbjct: 722 KVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANV--EFMDEALIMASVDHPH 779 Query: 231 LVKMIGICIERRTRCLVFELVPNGSVESHLH-GSDKIYGPLDFDTRMKIALGAARGLAYL 407 LV+++G+C+ T LV +L+P+G + ++H D I L + ++I A+G+ YL Sbjct: 780 LVRLLGVCLS-PTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQI----AKGMMYL 834 Query: 408 HEDANPHVIHRD 443 E ++HRD Sbjct: 835 EE---RRLVHRD 843
>M3K6_HUMAN (O95382) Mitogen-activated protein kinase kinase kinase 6 (EC| 2.7.11.25) Length = 1011 Score = 55.8 bits (133), Expect = 5e-08 Identities = 38/128 (29%), Positives = 65/128 (50%), Gaps = 4/128 (3%) Frame = +3 Query: 78 IIGEGGYGRVYRGIVQDG-VEVAVKLLTGKHQNRDREFIAEVEMLSRLHHRNLVKMIGIC 254 ++G+G YG VY G + V +A+K + + + E+ + RL H+N+V+ +G Sbjct: 376 VLGKGTYGVVYAGRDRHTRVRIAIKEIPERDSRFSQPLHEEIALHRRLRHKNIVRYLGSA 435 Query: 255 IERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIAL---GAARGLAYLHEDANP 425 + + E VP GS+ S L ++GPL D I+ +GL YLH++ Sbjct: 436 SQGGYLKIFMEEVPGGSLSSLLR---SVWGPLK-DNESTISFYTRQILQGLGYLHDN--- 488 Query: 426 HVIHRDFR 449 H++HRD + Sbjct: 489 HIVHRDIK 496
>M3K1_ARATH (O22040) Mitogen-activated protein kinase kinase kinase 1 (EC| 2.7.11.25) (Arabidospsis NPK1-related protein kinase 1) Length = 666 Score = 55.8 bits (133), Expect = 5e-08 Identities = 43/134 (32%), Positives = 63/134 (47%), Gaps = 9/134 (6%) Frame = +3 Query: 75 RIIGEGGYGRVYRGIVQDGVEV-AVKLLT--------GKHQNRDREFIAEVEMLSRLHHR 227 ++IG G +G VY G+ D E+ AVK + K Q +E EV++L L H Sbjct: 73 QLIGRGAFGTVYMGMNLDSGELLAVKQVLIAANFASKEKTQAHIQELEEEVKLLKNLSHP 132 Query: 228 NLVKMIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYL 407 N+V+ +G E T ++ E VP GS+ S L + +GP GL YL Sbjct: 133 NIVRYLGTVREDDTLNILLEFVPGGSISSLL----EKFGPFPESVVRTYTRQLLLGLEYL 188 Query: 408 HEDANPHVIHRDFR 449 H A ++HRD + Sbjct: 189 HNHA---IMHRDIK 199
>CDC15_YEAST (P27636) Cell division control protein 15 (EC 2.7.11.1)| Length = 974 Score = 55.8 bits (133), Expect = 5e-08 Identities = 40/146 (27%), Positives = 73/146 (50%), Gaps = 4/146 (2%) Frame = +3 Query: 30 SISELEKATDK---FSFNRIIGEGGYGRVYRGIVQDGVEV-AVKLLTGKHQNRDREFIAE 197 +++ +++A++K + ++IG G YG VY+ I + +V A+K + ++ + +AE Sbjct: 11 NLTPIQRASEKSVQYHLKQVIGRGSYGVVYKAINKHTDQVVAIKEVVYENDEELNDIMAE 70 Query: 198 VEMLSRLHHRNLVKMIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIA 377 + +L L+H N+VK G + ++ E NGS+ + S + T + Sbjct: 71 ISLLKNLNHNNIVKYHGFIRKSYELYILLEYCANGSLRRLISRSSTGLSENESKTYVTQT 130 Query: 378 LGAARGLAYLHEDANPHVIHRDFRLA 455 L GL YLH + VIHRD + A Sbjct: 131 L---LGLKYLHGEG---VIHRDIKAA 150
>EPHA3_HUMAN (P29320) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ETK1) (HEK) (HEK4) Length = 983 Score = 55.1 bits (131), Expect = 9e-08 Identities = 37/147 (25%), Positives = 74/147 (50%), Gaps = 7/147 (4%) Frame = +3 Query: 24 TFSISELEKATD--KFSFNRIIGEGGYGRVYRGIVQ----DGVEVAVKLL-TGKHQNRDR 182 T ++ E K D S ++++G G +G V G ++ + VA+K L G + + R Sbjct: 606 TQAVHEFAKELDATNISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRR 665 Query: 183 EFIAEVEMLSRLHHRNLVKMIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDT 362 +F+ E ++ + H N++++ G+ + + +V E + NGS++S L D + + Sbjct: 666 DFLGEASIMGQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFTVIQLVG 725 Query: 363 RMKIALGAARGLAYLHEDANPHVIHRD 443 ++ G A G+ YL ++ +HRD Sbjct: 726 MLR---GIASGMKYL---SDMGYVHRD 746
>LIMK2_CHICK (P53666) LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2)| Length = 642 Score = 55.1 bits (131), Expect = 9e-08 Identities = 33/123 (26%), Positives = 64/123 (52%), Gaps = 1/123 (0%) Frame = +3 Query: 78 IIGEGGYGRVYRGIVQ-DGVEVAVKLLTGKHQNRDREFIAEVEMLSRLHHRNLVKMIGIC 254 ++G+G +G+ + + G + +K L + + F+ EV+++ L H N++K IG+ Sbjct: 336 VLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVL 395 Query: 255 IERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVI 434 + + L+ E + G+++ L +D P + ++ A G A G+AYLH +I Sbjct: 396 YKDKKLNLLTEYIEGGTLKDFLRNAD----PFPWQQKVSFAKGIASGMAYLHSMC---II 448 Query: 435 HRD 443 HRD Sbjct: 449 HRD 451
>7LESS_DROME (P13368) Protein sevenless (EC 2.7.10.1)| Length = 2554 Score = 55.1 bits (131), Expect = 9e-08 Identities = 38/140 (27%), Positives = 66/140 (47%), Gaps = 12/140 (8%) Frame = +3 Query: 75 RIIGEGGYGRVYRGIV-----QDGVEVAVKLLTGKHQNRDREFIAEVEMLSRLHHRNLVK 239 R +G G +G VY G + ++ VA+K L K + E + E +++S H N+V Sbjct: 2213 RFLGSGAFGEVYEGQLKTEDSEEPQRVAIKSLR-KGASEFAELLQEAQLMSNFKHENIVC 2271 Query: 240 MIGICIERRTRCLVFELVPNGSVESHLHGS-------DKIYGPLDFDTRMKIALGAARGL 398 ++GIC + + L+ E + G + S+L + + L + + + A G Sbjct: 2272 LVGICFDTESISLIMEHMEAGDLLSYLRAARATSTQEPQPTAGLSLSELLAMCIDVANGC 2331 Query: 399 AYLHEDANPHVIHRDFRLAC 458 +YL + H +HRD LAC Sbjct: 2332 SYLED---MHFVHRD--LAC 2346
>LIMK2_HUMAN (P53671) LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2)| Length = 638 Score = 55.1 bits (131), Expect = 9e-08 Identities = 33/123 (26%), Positives = 64/123 (52%), Gaps = 1/123 (0%) Frame = +3 Query: 78 IIGEGGYGRVYRGIVQ-DGVEVAVKLLTGKHQNRDREFIAEVEMLSRLHHRNLVKMIGIC 254 ++G+G +G+ + + G + +K L + + F+ EV+++ L H N++K IG+ Sbjct: 336 VLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVL 395 Query: 255 IERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVI 434 + + L+ E + G+++ L D P + +++ A G A G+AYLH +I Sbjct: 396 YKDKKLNLLTEYIEGGTLKDFLRSMD----PFPWQQKVRFAKGIASGMAYLHSMC---II 448 Query: 435 HRD 443 HRD Sbjct: 449 HRD 451
>LIMK2_RAT (P53670) LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2)| Length = 638 Score = 54.7 bits (130), Expect = 1e-07 Identities = 33/123 (26%), Positives = 64/123 (52%), Gaps = 1/123 (0%) Frame = +3 Query: 78 IIGEGGYGRVYRGIVQ-DGVEVAVKLLTGKHQNRDREFIAEVEMLSRLHHRNLVKMIGIC 254 ++G+G +G+ + + G + +K L + + F+ EV+++ L H N++K IG+ Sbjct: 336 VLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVL 395 Query: 255 IERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVI 434 + + L+ E + G+++ L D P + +++ A G A G+AYLH +I Sbjct: 396 YKDKKLNLLTEYIEGGTLKDFLRNVD----PFPWQQKVRFAKGIASGMAYLHSMC---II 448 Query: 435 HRD 443 HRD Sbjct: 449 HRD 451
>FAK2_HUMAN (Q14289) Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal| adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinas Length = 1009 Score = 54.7 bits (130), Expect = 1e-07 Identities = 40/136 (29%), Positives = 70/136 (51%), Gaps = 5/136 (3%) Frame = +3 Query: 51 ATDKFSFNRIIGEGGYGRVYRGIVQD--GVEVAVKLLTGKHQ---NRDREFIAEVEMLSR 215 A + NRI+GEG +G VY G+ + G ++ V + T K + +F++E ++ Sbjct: 421 AREDVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKN 480 Query: 216 LHHRNLVKMIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARG 395 L H ++VK+IGI IE ++ EL P G + +L ++ L T + +L + Sbjct: 481 LDHPHIVKLIGI-IEEEPTWIIMELYPYGELGHYL---ERNKNSLKVLTLVLYSLQICKA 536 Query: 396 LAYLHEDANPHVIHRD 443 +AYL + + +HRD Sbjct: 537 MAYLE---SINCVHRD 549
>SRK3_SPOLA (P42689) Tyrosine-protein kinase SRK3 (EC 2.7.10.2) (Fragment)| Length = 334 Score = 54.7 bits (130), Expect = 1e-07 Identities = 33/130 (25%), Positives = 65/130 (50%), Gaps = 4/130 (3%) Frame = +3 Query: 39 ELEKATDKFSFNRIIGEGGYGRVYRGIVQDGVEVAVKLLTGKHQNRDREFIAEVEMLSRL 218 E+++ T R +G+G +G V+ G+ VAVK L ++F+ E +++ ++ Sbjct: 60 EIDRTT--IQLQRKLGQGNFGEVWAGVWNGTTAVAVKTLKPDTMEV-KDFVQEAQVMKKI 116 Query: 219 HHRNLVKMIGICIERRTRCLVFELVPNGSVESHL-HGSDK---IYGPLDFDTRMKIALGA 386 HH NL+++ +C +V EL+ GS+ +L HG K ++ +D ++ + Sbjct: 117 HHPNLLQLYAVCTIGEPIYIVTELMKYGSMLEYLKHGEGKNITLHQMVDMSAQIASGMTY 176 Query: 387 ARGLAYLHED 416 +Y+H D Sbjct: 177 LEAHSYIHRD 186
>PTK6_MOUSE (Q64434) Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related| intestinal kinase) Length = 451 Score = 54.7 bits (130), Expect = 1e-07 Identities = 34/137 (24%), Positives = 71/137 (51%), Gaps = 4/137 (2%) Frame = +3 Query: 45 EKATDKFSFNRIIGEGGYGRVYRGIVQDGVEVAVKLLTGKHQNRDREFIAEVEMLSRLHH 224 E+ ++F+ + +G G +G V+ + + V VAVK+++ + F AE++ + +L H Sbjct: 185 ERPREEFTLCKKLGAGYFGEVFEALWKGQVHVAVKVISRDNLLHQHTFQAEIQAMKKLRH 244 Query: 225 RNLVKMIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPL----DFDTRMKIALGAAR 392 ++++ + + ++ EL+P G++ L SD+ P+ DF +++ A Sbjct: 245 KHILSLYAVATAGDPVYIITELMPKGNLLQLLRDSDEKALPILELVDFASQV------AE 298 Query: 393 GLAYLHEDANPHVIHRD 443 G+ YL + + IHRD Sbjct: 299 GMCYLE---SQNYIHRD 312
>EPHA3_CHICK (P29318) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ETK1) (CEK4) Length = 983 Score = 54.3 bits (129), Expect = 2e-07 Identities = 36/145 (24%), Positives = 73/145 (50%), Gaps = 7/145 (4%) Frame = +3 Query: 30 SISELEKATD--KFSFNRIIGEGGYGRVYRGIVQ----DGVEVAVKLL-TGKHQNRDREF 188 ++ E K D S ++++G G +G V G ++ + VA+K L G + + R+F Sbjct: 608 AVHEFAKELDASNISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKAGYTEKQRRDF 667 Query: 189 IAEVEMLSRLHHRNLVKMIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRM 368 + E ++ + H N++++ G+ + + +V E + NGS++S L D + + + Sbjct: 668 LGEASIMGQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFTVIQLVGML 727 Query: 369 KIALGAARGLAYLHEDANPHVIHRD 443 + G A G+ YL ++ +HRD Sbjct: 728 R---GIASGMKYL---SDMGYVHRD 746
>JAK2_HUMAN (O60674) Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase| 2) (JAK-2) Length = 1132 Score = 54.3 bits (129), Expect = 2e-07 Identities = 33/128 (25%), Positives = 64/128 (50%), Gaps = 8/128 (6%) Frame = +3 Query: 69 FNRIIGEGGYGRVYRGIVQD--------GVEVAVKLLTGKHQNRDREFIAEVEMLSRLHH 224 FN +G+G + ++++G+ ++ EV +K+L H+N F M+S+L H Sbjct: 547 FNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSH 606 Query: 225 RNLVKMIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAY 404 ++LV G+C+ LV E V GS++++L + L ++++A A + + Sbjct: 607 KHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINIL---WKLEVAKQLAWAMHF 663 Query: 405 LHEDANPH 428 L E+ H Sbjct: 664 LEENTLIH 671 Score = 50.4 bits (119), Expect = 2e-06 Identities = 42/132 (31%), Positives = 62/132 (46%), Gaps = 7/132 (5%) Frame = +3 Query: 69 FNRIIGEGGYGRVYR---GIVQD--GVEVAVKLLTGKHQNRDREFIAEVEMLSRLHHRNL 233 F + +G+G +G V +QD G VAVK L + R+F E+E+L L H N+ Sbjct: 851 FLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNI 910 Query: 234 VKMIGICIE--RRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYL 407 VK G+C RR L+ E +P GS+ +L K +D ++ +G+ YL Sbjct: 911 VKYKGVCYSAGRRNLKLIMEYLPYGSLRDYL---QKHKERIDHIKLLQYTSQICKGMEYL 967 Query: 408 HEDANPHVIHRD 443 IHRD Sbjct: 968 ---GTKRYIHRD 976
>EPHA3_RAT (O08680) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor REK4) (TYRO-4) Length = 984 Score = 53.9 bits (128), Expect = 2e-07 Identities = 36/147 (24%), Positives = 74/147 (50%), Gaps = 7/147 (4%) Frame = +3 Query: 24 TFSISELEKATD--KFSFNRIIGEGGYGRVYRGIVQ----DGVEVAVKLL-TGKHQNRDR 182 T ++ E K D + ++++G G +G V G ++ + VA+K L G + + R Sbjct: 607 TQAVHEFAKELDATNIAIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRR 666 Query: 183 EFIAEVEMLSRLHHRNLVKMIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDT 362 +F+ E ++ + H N++++ G+ + + +V E + NGS++S L D + + Sbjct: 667 DFLGEASIMGQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFTVIQLVG 726 Query: 363 RMKIALGAARGLAYLHEDANPHVIHRD 443 ++ G A G+ YL ++ +HRD Sbjct: 727 MLR---GIASGMKYL---SDMGYVHRD 747
>PTK7_CHICK (Q91048) Tyrosine-protein kinase-like 7 precursor (Kinase-like| protein) Length = 1051 Score = 53.9 bits (128), Expect = 2e-07 Identities = 42/154 (27%), Positives = 69/154 (44%), Gaps = 18/154 (11%) Frame = +3 Query: 36 SELEKATDKFSFNR-------IIGEGGYGRVYRGIVQDGVE------VAVKLLTGKHQNR 176 S+ A DK F R +G G +G V+ + + V VK L + + Sbjct: 761 SKRHSARDKMHFPRSNLQTITTLGRGEFGEVFLAKAKGAEDAEGEALVLVKSLQTRDEQL 820 Query: 177 DREFIAEVEMLSRLHHRNLVKMIGICIERRTRCLVFELVPNGSVESHLH---GSDKIYGP 347 +F E EM +L+H N+V+++G+C E +V E V G ++ L D+ P Sbjct: 821 QLDFRREAEMFGKLNHVNVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDESLKP 880 Query: 348 LDFDTRMKIAL--GAARGLAYLHEDANPHVIHRD 443 T+ K++L A G+ +L +N +HRD Sbjct: 881 QPLSTKHKVSLCTQVALGMEHL---SNGRFVHRD 911
>INSR_XENLA (Q9PVZ4) Insulin receptor precursor (EC 2.7.10.1) (IR) (Xe-InsR)| (XTK-1b) [Contains: Insulin receptor alpha subunit; Insulin receptor beta subunit] Length = 1362 Score = 53.9 bits (128), Expect = 2e-07 Identities = 41/148 (27%), Positives = 73/148 (49%), Gaps = 13/148 (8%) Frame = +3 Query: 39 ELEKATDKFSFNRIIGEGGYGRVYRGIVQD------GVEVAVKLLTGKHQNRDR-EFIAE 197 E E DK + R +G+G +G VY GI +D V VAVK + R+R EF+ E Sbjct: 1004 EWEVPRDKINLLRELGQGSFGMVYEGIAKDIIKGEPEVRVAVKTVNESASLRERIEFLNE 1063 Query: 198 VEMLSRLHHRNLVKMIGICIERRTRCLVFELVPNGSVESHLHG--SDKIYGPLDFDTRMK 371 ++ + ++V+++G+ + + ++ EL+ +G ++S+L D P +K Sbjct: 1064 ASVMKAFNCHHVVRLLGVVSKGQPTLVIMELMAHGDLKSYLRSLRPDAENNPGRLAPTLK 1123 Query: 372 ----IALGAARGLAYLHEDANPHVIHRD 443 +A + G+AYL+ +HRD Sbjct: 1124 EIIQMAAEISDGMAYLNA---KKFVHRD 1148
>SRC64_DROME (P00528) Tyrosine-protein kinase Src64B (EC 2.7.10.2) (Dsrc64)| Length = 552 Score = 53.9 bits (128), Expect = 2e-07 Identities = 36/123 (29%), Positives = 59/123 (47%) Frame = +3 Query: 75 RIIGEGGYGRVYRGIVQDGVEVAVKLLTGKHQNRDREFIAEVEMLSRLHHRNLVKMIGIC 254 R +G G +G V+ G ++ ++VAVK L + F+ E ++ + H LV + +C Sbjct: 288 RKLGRGNFGEVFYGKWRNSIDVAVKTLR-EGTMSTAAFLQEAAIMKKFRHNRLVALYAVC 346 Query: 255 IERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVI 434 + +V E + GS+ L D Y L F+ + IA A G+ YL + +I Sbjct: 347 SQEEPIYIVQEYMSKGSLLDFLREGDGRY--LHFEDLIYIATQVASGMEYLE---SKQLI 401 Query: 435 HRD 443 HRD Sbjct: 402 HRD 404
>MIPR_LYMST (Q25410) Putative molluscan insulin-related peptide(s) receptor| precursor (EC 2.7.10.1) [Contains: Putative molluscan insulin-related peptide(s) receptor alpha chain; Putative molluscan insulin-related peptide(s) receptor beta chain] Length = 1607 Score = 53.9 bits (128), Expect = 2e-07 Identities = 41/158 (25%), Positives = 75/158 (47%), Gaps = 14/158 (8%) Frame = +3 Query: 12 PTVKTFSISELEKATDKFSFNRIIGEGGYGRVYRGIVQ-------DGVEVAVKLLTGKHQ 170 P+ + E E DK + +G+G +G VY G+ + + + VAVK + + Sbjct: 1020 PSEILYISDEWEVDRDKIKLIKELGQGSFGMVYEGVAKGIRDDPNEEIPVAVKTVNDRAS 1079 Query: 171 NRD-REFIAEVEMLSRLHHRNLVKMIGICIERRTRCLVFELVPNGSVESHLHG------S 329 D REF+ E + H ++VK++G+ + ++ EL+ G ++++L G Sbjct: 1080 FSDRREFLKEATTMKEFHCHHVVKLLGVVSTGQPALVIMELMALGDLKNYLRGHRPDEDH 1139 Query: 330 DKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRD 443 + P D +++A A G+AYL A+ +HRD Sbjct: 1140 PGVMPPHLLDI-LQMAGEIADGMAYL---ADKKFVHRD 1173
>IRAK3_HUMAN (Q9Y616) Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1)| (IRAK-3) (IL-1 receptor-associated kinase M) (IRAK-M) Length = 596 Score = 53.9 bits (128), Expect = 2e-07 Identities = 36/133 (27%), Positives = 68/133 (51%), Gaps = 4/133 (3%) Frame = +3 Query: 24 TFSISELEKATDKFSFNRIIGEGGYGRVYRGIVQDGVEVAVKLLTGKHQNRDRE----FI 191 + S + + T F + +IGEG VYR +Q+ + AVKL + + + ++ F+ Sbjct: 152 SISFQNIIEGTRNFHKDFLIGEGEIFEVYRVEIQN-LTYAVKLFKQEKKMQCKKHWKRFL 210 Query: 192 AEVEMLSRLHHRNLVKMIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMK 371 +E+E+L HH N++++ E CL++ + NG++ L PL + R+ Sbjct: 211 SELEVLLLFHHPNILELAAYFTETEKFCLIYPYMRNGTLFDRLQCVGDT-APLPWHIRIG 269 Query: 372 IALGAARGLAYLH 410 I +G ++ + YLH Sbjct: 270 ILIGISKAIHYLH 282
>ROR2_DROME (Q9V6K3) Tyrosine-protein kinase transmembrane receptor Ror2| precursor (EC 2.7.10.1) (Neurospecific receptor tyrosine kinase) Length = 724 Score = 53.9 bits (128), Expect = 2e-07 Identities = 42/154 (27%), Positives = 73/154 (47%), Gaps = 17/154 (11%) Frame = +3 Query: 33 ISELEKATDKFSFNRIIGEGGYGRVYR----GIV--QDGVEVAVKLLTGKHQNR-DREFI 191 + +LE + R +G+G +GRV++ G+V Q+ + VAVK+L ++ +F Sbjct: 431 LEKLEYPRGDIVYVRSLGQGAFGRVFQARAPGLVPDQEDLLVAVKMLKDDASDQMQMDFE 490 Query: 192 AEVEMLSRLHHRNLVKMIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTR-- 365 E +L+ H N+V+++G+C R CL+FE + G + L Y T+ Sbjct: 491 REACLLAEFDHPNIVRLLGVCALGRPMCLLFEYMAPGDLSEFLRACSP-YATHQAPTQDR 549 Query: 366 --------MKIALGAARGLAYLHEDANPHVIHRD 443 +++A A G+ YL E +HRD Sbjct: 550 LQLNELHLLQMAANIAAGMLYLSE---RKFVHRD 580
>MERTK_HUMAN (Q12866) Proto-oncogene tyrosine-protein kinase MER precursor (EC| 2.7.10.1) (C-mer) (Receptor tyrosine kinase MerTK) Length = 999 Score = 53.9 bits (128), Expect = 2e-07 Identities = 37/136 (27%), Positives = 68/136 (50%), Gaps = 13/136 (9%) Frame = +3 Query: 75 RIIGEGGYGRVYRGIV--QDGVEVAVKLLTGKHQNRDR----EFIAEVEMLSRLHHRNLV 236 +I+GEG +G V G + +DG + V + T K N EF++E + H N++ Sbjct: 591 KILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSHREIEEFLSEAACMKDFSHPNVI 650 Query: 237 KMIGICIERRTR-----CLVFELVPNGSVESHLHGSDKIYGP--LDFDTRMKIALGAARG 395 +++G+CIE ++ ++ + G + ++L S GP + T +K + A G Sbjct: 651 RLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDIALG 710 Query: 396 LAYLHEDANPHVIHRD 443 + YL +N + +HRD Sbjct: 711 MEYL---SNRNFLHRD 723
>EPHA8_RAT (P29321) Ephrin type-A receptor 8 (EC 2.7.10.1) (Tyrosine-protein| kinase receptor EEK) (EPH- and ELK-related kinase) (Fragment) Length = 372 Score = 53.9 bits (128), Expect = 2e-07 Identities = 41/142 (28%), Positives = 65/142 (45%), Gaps = 9/142 (6%) Frame = +3 Query: 60 KFSFNRIIGEGGYGRVYRGIVQ----DGVEVAVKLLTGKHQNRDRE-FIAEVEMLSRLHH 224 + +IIG G G V G +Q V VA+K L + R R+ F+ E ++ + H Sbjct: 1 RIHIEKIIGSGESGEVCYGRLQVPGQRDVPVAIKALKAGYTERQRQDFLREAAIMGQFDH 60 Query: 225 RNLVKMIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAA----R 392 N++++ G+ R +V E + NGS+++ L D + L +K +GA Sbjct: 61 PNIIRLEGVVTRGRLAMIVTEYMENGSLDAFLRTHDGQFTILQLVGMLK-GVGAGMRYLS 119 Query: 393 GLAYLHEDANPHVIHRDFRLAC 458 L Y+H D I D RL C Sbjct: 120 DLGYIHRDLAARNILVDGRLVC 141
>M3K2_MOUSE (Q61083) Mitogen-activated protein kinase kinase kinase 2 (EC| 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2) Length = 619 Score = 53.9 bits (128), Expect = 2e-07 Identities = 40/147 (27%), Positives = 69/147 (46%), Gaps = 9/147 (6%) Frame = +3 Query: 36 SELEKATDKFSFNRIIGEGGYGRVYRGI-VQDGVEVAVKLLTGKHQNRD-----REFIAE 197 S +A + +++G+G +GRVY V G E+AVK + ++ + E Sbjct: 347 SRSPRAPTNWRLGKLLGQGAFGRVYLCYDVDTGRELAVKQVQFNPESPETSKEVNALECE 406 Query: 198 VEMLSRLHHRNLVKMIGICI---ERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRM 368 +++L L H +V+ G C+ + +T + EL P GS++ L K YG L + Sbjct: 407 IQLLKNLLHERIVQYYG-CLRDPQEKTLSIFMELSPGGSIKDQL----KAYGALTENVTR 461 Query: 369 KIALGAARGLAYLHEDANPHVIHRDFR 449 K G+ YLH + ++HRD + Sbjct: 462 KYTRQILEGVHYLHSNM---IVHRDIK 485
>M3K2_HUMAN (Q9Y2U5) Mitogen-activated protein kinase kinase kinase 2 (EC| 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2) Length = 619 Score = 53.9 bits (128), Expect = 2e-07 Identities = 45/161 (27%), Positives = 73/161 (45%), Gaps = 15/161 (9%) Frame = +3 Query: 12 PTVKTFSIS---ELEKATDKFSFNRIIGEGGYGRVYRGI-VQDGVEVAVKLL-------- 155 PT+ IS +A + +++G+G +GRVY V G E+AVK + Sbjct: 336 PTLTVMDISPPSRSPRAPTNWRLGKLLGQGAFGRVYLCYDVDTGRELAVKQVQFDPDSPE 395 Query: 156 TGKHQNRDREFIAEVEMLSRLHHRNLVKMIGICI---ERRTRCLVFELVPNGSVESHLHG 326 T K N E+++L L H +V+ G C+ + +T + E +P GS++ L Sbjct: 396 TSKEVN---ALECEIQLLKNLLHERIVQYYG-CLRDPQEKTLSIFMEYMPGGSIKDQL-- 449 Query: 327 SDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFR 449 K YG L + K G+ YLH + ++HRD + Sbjct: 450 --KAYGALTENVTRKYTRQILEGVHYLHSNM---IVHRDIK 485
>EPHB3_XENLA (Q91735) Ephrin type-B receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor TCK) Length = 974 Score = 53.9 bits (128), Expect = 2e-07 Identities = 36/127 (28%), Positives = 64/127 (50%), Gaps = 5/127 (3%) Frame = +3 Query: 78 IIGEGGYGRVYRGIVQDGVE----VAVKLL-TGKHQNRDREFIAEVEMLSRLHHRNLVKM 242 +IG G +G V RG ++ VA+K L G + + R+F+ E ++ + H N++++ Sbjct: 614 VIGAGEFGEVCRGKLKQAGRREQFVAIKTLKAGYTEQQRRDFLGEASIMGQFDHPNIIRL 673 Query: 243 IGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDAN 422 G+ R ++ E + NG+++S L +D G + I G A G+ YL E Sbjct: 674 EGVVTRSRPVMILTEFMENGALDSFLRMND---GQFTVIQLVGILRGIASGMKYLSE--- 727 Query: 423 PHVIHRD 443 + +HRD Sbjct: 728 MNYVHRD 734
>SRK4_SPOLA (P42690) Tyrosine-protein kinase isoform SRK4 (EC 2.7.10.2)| Length = 506 Score = 53.9 bits (128), Expect = 2e-07 Identities = 38/135 (28%), Positives = 66/135 (48%) Frame = +3 Query: 39 ELEKATDKFSFNRIIGEGGYGRVYRGIVQDGVEVAVKLLTGKHQNRDREFIAEVEMLSRL 218 E+EK K R +G G +G V+ G+ VAVK L + + EF+ E ++ +L Sbjct: 234 EIEKKQIKLL--RGLGAGQFGEVWEGLWNGTTSVAVKTLKPGTMSIE-EFLEEASIMKQL 290 Query: 219 HHRNLVKMIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGL 398 H L+++ +C + +V EL+ +GS+ +L G + L + + A G+ Sbjct: 291 RHPKLIQLYAVCTKEEPIYIVTELMKHGSLLEYLRGDGR---SLKLPDLVDMCSQVASGM 347 Query: 399 AYLHEDANPHVIHRD 443 +YL + + IHRD Sbjct: 348 SYLEQQ---NYIHRD 359
>CSK_CHICK (P41239) Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase)| Length = 450 Score = 53.9 bits (128), Expect = 2e-07 Identities = 39/124 (31%), Positives = 70/124 (56%), Gaps = 1/124 (0%) Frame = +3 Query: 75 RIIGEGGYGRVYRGIVQDGVEVAVKLLTGKHQNRDREFIAEVEMLSRLHHRNLVKMIGIC 254 +IIG+G +G V G + G +VAVK + K+ + F+AE ++++L H NLV+++G+ Sbjct: 199 QIIGKGEFGDVMLGDYR-GNKVAVKCI--KNDATAQAFLAEASVMTQLRHSNLVQLLGVI 255 Query: 255 IERRTRC-LVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHV 431 +E ++ +V E + GS+ +L + L D +K +L + YL +AN + Sbjct: 256 VEEKSGLYIVTEYMAKGSLVDYLRSRGR--SVLGGDCLLKFSLDVCEAMEYL--EAN-NF 310 Query: 432 IHRD 443 +HRD Sbjct: 311 VHRD 314
>TIE2_HUMAN (Q02763) Angiopoietin-1 receptor precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (CD202b antigen) Length = 1124 Score = 53.5 bits (127), Expect = 3e-07 Identities = 42/142 (29%), Positives = 66/142 (46%), Gaps = 17/142 (11%) Frame = +3 Query: 69 FNRIIGEGGYGRVYRG-IVQDGV--EVAVKLLTGKHQNRD-REFIAEVEMLSRL-HHRNL 233 F +IGEG +G+V + I +DG+ + A+K + D R+F E+E+L +L HH N+ Sbjct: 826 FQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNI 885 Query: 234 VKMIGICIERRTRCLVFELVPNGSVESHLHGS------------DKIYGPLDFDTRMKIA 377 + ++G C R L E P+G++ L S + L + A Sbjct: 886 INLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFA 945 Query: 378 LGAARGLAYLHEDANPHVIHRD 443 ARG+ YL + IHRD Sbjct: 946 ADVARGMDYL---SQKQFIHRD 964
>TIE2_BOVIN (Q06807) Angiopoietin-1 receptor precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor TIE-2) (CD202b antigen) Length = 1125 Score = 53.5 bits (127), Expect = 3e-07 Identities = 42/142 (29%), Positives = 66/142 (46%), Gaps = 17/142 (11%) Frame = +3 Query: 69 FNRIIGEGGYGRVYRG-IVQDGV--EVAVKLLTGKHQNRD-REFIAEVEMLSRL-HHRNL 233 F +IGEG +G+V + I +DG+ + A+K + D R+F E+E+L +L HH N+ Sbjct: 827 FQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNI 886 Query: 234 VKMIGICIERRTRCLVFELVPNGSVESHLHGS------------DKIYGPLDFDTRMKIA 377 + ++G C R L E P+G++ L S + L + A Sbjct: 887 INLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFA 946 Query: 378 LGAARGLAYLHEDANPHVIHRD 443 ARG+ YL + IHRD Sbjct: 947 ADVARGMDYL---SQKQFIHRD 965
>LIMK1_CHICK (Q8QFP8) LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (chLIMK1)| Length = 662 Score = 53.5 bits (127), Expect = 3e-07 Identities = 34/123 (27%), Positives = 63/123 (51%), Gaps = 1/123 (0%) Frame = +3 Query: 78 IIGEGGYGRVYRGIVQDGVEVAV-KLLTGKHQNRDREFIAEVEMLSRLHHRNLVKMIGIC 254 ++G+G +G+ + ++ EV V K L + R F+ EV+++ L H N++K IG+ Sbjct: 351 VLGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGVL 410 Query: 255 IERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVI 434 + + + E + G++ + D Y + R+ A A G+AYLH + ++I Sbjct: 411 YKEKRLNFITEYIKGGTLRGLIKSMDSHY---PWSQRVSFAKDIAAGMAYLH---SMNII 464 Query: 435 HRD 443 HRD Sbjct: 465 HRD 467
>LIMK2_MOUSE (O54785) LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2)| Length = 638 Score = 53.5 bits (127), Expect = 3e-07 Identities = 32/123 (26%), Positives = 64/123 (52%), Gaps = 1/123 (0%) Frame = +3 Query: 78 IIGEGGYGRVYRGIVQ-DGVEVAVKLLTGKHQNRDREFIAEVEMLSRLHHRNLVKMIGIC 254 ++G+G +G+ + + G + +K L + + F+ EV+++ L H N++K IG+ Sbjct: 336 VLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVL 395 Query: 255 IERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVI 434 + + L+ E + G+++ L D P + +++ A G + G+AYLH +I Sbjct: 396 YKDKKLNLLTEYIEGGTLKDFLRSVD----PFPWQQKVRFAKGISSGMAYLHSMC---II 448 Query: 435 HRD 443 HRD Sbjct: 449 HRD 451
>JAK2_RAT (Q62689) Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase| 2) (JAK-2) Length = 1132 Score = 53.5 bits (127), Expect = 3e-07 Identities = 27/92 (29%), Positives = 50/92 (54%), Gaps = 8/92 (8%) Frame = +3 Query: 69 FNRIIGEGGYGRVYRGIVQD--------GVEVAVKLLTGKHQNRDREFIAEVEMLSRLHH 224 FN +G+G + ++++G+ ++ EV +K+L H+N F M+S+L H Sbjct: 547 FNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSQLSH 606 Query: 225 RNLVKMIGICIERRTRCLVFELVPNGSVESHL 320 ++LV G+C+ LV E V GS++++L Sbjct: 607 KHLVLNYGVCVCGEENILVQEFVKFGSLDTYL 638 Score = 51.2 bits (121), Expect = 1e-06 Identities = 42/132 (31%), Positives = 62/132 (46%), Gaps = 7/132 (5%) Frame = +3 Query: 69 FNRIIGEGGYGRVYR---GIVQD--GVEVAVKLLTGKHQNRDREFIAEVEMLSRLHHRNL 233 F + +G+G +G V +QD G VAVK L + R+F E+E+L L H N+ Sbjct: 851 FLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNI 910 Query: 234 VKMIGICIE--RRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYL 407 VK G+C RR L+ E +P GS+ +L K +D ++ +G+ YL Sbjct: 911 VKYKGVCYSAGRRNLRLIMEYLPYGSLRDYL---QKHKERIDHKKLLQYTSQICKGMEYL 967 Query: 408 HEDANPHVIHRD 443 IHRD Sbjct: 968 ---GTKRYIHRD 976
>JAK2_MOUSE (Q62120) Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase| 2) (JAK-2) Length = 1129 Score = 53.5 bits (127), Expect = 3e-07 Identities = 27/92 (29%), Positives = 50/92 (54%), Gaps = 8/92 (8%) Frame = +3 Query: 69 FNRIIGEGGYGRVYRGIVQD--------GVEVAVKLLTGKHQNRDREFIAEVEMLSRLHH 224 FN +G+G + ++++G+ ++ EV +K+L H+N F M+S+L H Sbjct: 547 FNESLGQGTFTKIFKGVRREVGDYGQLHKTEVLLKVLDKAHRNYSESFFEAASMMSQLSH 606 Query: 225 RNLVKMIGICIERRTRCLVFELVPNGSVESHL 320 ++LV G+C+ LV E V GS++++L Sbjct: 607 KHLVLNYGVCVCGEENILVQEFVKFGSLDTYL 638 Score = 51.2 bits (121), Expect = 1e-06 Identities = 42/132 (31%), Positives = 62/132 (46%), Gaps = 7/132 (5%) Frame = +3 Query: 69 FNRIIGEGGYGRVYR---GIVQD--GVEVAVKLLTGKHQNRDREFIAEVEMLSRLHHRNL 233 F + +G+G +G V +QD G VAVK L + R+F E+E+L L H N+ Sbjct: 851 FLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNI 910 Query: 234 VKMIGICIE--RRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYL 407 VK G+C RR L+ E +P GS+ +L K +D ++ +G+ YL Sbjct: 911 VKYKGVCYSAGRRNLRLIMEYLPYGSLRDYL---QKHKERIDHKKLLQYTSQICKGMEYL 967 Query: 408 HEDANPHVIHRD 443 IHRD Sbjct: 968 ---GTKRYIHRD 976
>TIE2_MOUSE (Q02858) Angiopoietin-1 receptor precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (HYK) (STK1) (CD202b antigen) Length = 1122 Score = 53.5 bits (127), Expect = 3e-07 Identities = 42/142 (29%), Positives = 66/142 (46%), Gaps = 17/142 (11%) Frame = +3 Query: 69 FNRIIGEGGYGRVYRG-IVQDGV--EVAVKLLTGKHQNRD-REFIAEVEMLSRL-HHRNL 233 F +IGEG +G+V + I +DG+ + A+K + D R+F E+E+L +L HH N+ Sbjct: 824 FQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNI 883 Query: 234 VKMIGICIERRTRCLVFELVPNGSVESHLHGS------------DKIYGPLDFDTRMKIA 377 + ++G C R L E P+G++ L S + L + A Sbjct: 884 INLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFA 943 Query: 378 LGAARGLAYLHEDANPHVIHRD 443 ARG+ YL + IHRD Sbjct: 944 ADVARGMDYL---SQKQFIHRD 962
>MYO3B_HUMAN (Q8WXR4) Myosin IIIB (EC 2.7.11.1)| Length = 1341 Score = 53.5 bits (127), Expect = 3e-07 Identities = 50/147 (34%), Positives = 68/147 (46%), Gaps = 8/147 (5%) Frame = +3 Query: 33 ISELEKATDKFSFNRIIGEGGYGRVYRGI-VQDGVEVAVKLLTGKHQNRDREFIAEVEML 209 + L TD + IG+G YG+VY+ +DG AVK+L + D E AE +L Sbjct: 17 LESLPDPTDTWEIIETIGKGTYGKVYKVTNKRDGSLAAVKIL-DPVSDMDEEIEAEYNIL 75 Query: 210 SRL-HHRNLVKMIGICIERRTRC------LVFELVPNGSVESHLHGSDKIYGPLDFDTRM 368 L +H N+VK G+ + C LV EL GSV + G + LD Sbjct: 76 QFLPNHPNVVKFYGM-FYKADHCVGGQLWLVLELCNGGSVTELVKGLLRCGQRLDEAMIS 134 Query: 369 KIALGAARGLAYLHEDANPHVIHRDFR 449 I GA GL +LH N +IHRD + Sbjct: 135 YILYGALLGLQHLH---NNRIIHRDVK 158
>TAOK2_XENLA (Q6GPK9) Serine/threonine-protein kinase TAO2 (EC 2.7.11.1)| (Thousand and one amino acid protein 2) Length = 1025 Score = 53.1 bits (126), Expect = 3e-07 Identities = 50/151 (33%), Positives = 71/151 (47%), Gaps = 4/151 (2%) Frame = +3 Query: 9 PPTVKTFSISELEKATDKFSFNRIIGEGGYGRVYRGI-VQDGVEVAVKLLT--GKHQNRD 179 P + F + EK F+ R IG G +G VY +++ VA+K ++ GK N Sbjct: 13 PEVAELFFKDDPEKL---FADLREIGHGSFGAVYFARDIRNNEVVAIKKMSYSGKQSNEK 69 Query: 180 -REFIAEVEMLSRLHHRNLVKMIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDF 356 ++ I EV+ L +L H N ++ G + T LV E GS L K PL Sbjct: 70 WQDIIKEVKFLQKLRHPNTIEYKGCYLREHTAWLVMEYCL-GSASDLLEVHKK---PLQE 125 Query: 357 DTRMKIALGAARGLAYLHEDANPHVIHRDFR 449 I GA +GLAYLH N ++IHRD + Sbjct: 126 MEIAAITHGALQGLAYLH---NHNMIHRDVK 153
>SRMS_HUMAN (Q9H3Y6) Tyrosine-protein kinase Srms (EC 2.7.10.2)| Length = 488 Score = 53.1 bits (126), Expect = 3e-07 Identities = 34/133 (25%), Positives = 65/133 (48%) Frame = +3 Query: 45 EKATDKFSFNRIIGEGGYGRVYRGIVQDGVEVAVKLLTGKHQNRDREFIAEVEMLSRLHH 224 E+ +F+ R +GEG +G V+ G+ + VA+K++ + + + E++ L L H Sbjct: 224 ERPHSEFALGRKLGEGYFGEVWEGLWLGSLPVAIKVIKSANM-KLTDLAKEIQTLKGLRH 282 Query: 225 RNLVKMIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAY 404 L+++ +C +V EL+ G++++ L + L + A A G++Y Sbjct: 283 ERLIRLHAVCSGGEPVYIVTELMRKGNLQAFLGTPEG--RALRLPPLLGFACQVAEGMSY 340 Query: 405 LHEDANPHVIHRD 443 L E V+HRD Sbjct: 341 LEEQ---RVVHRD 350
>EGFR_DROME (P04412) Epidermal growth factor receptor precursor (EC 2.7.10.1)| (Egfr) (Gurken receptor) (Protein torpedo) (Drosophila relative of ERBB) Length = 1426 Score = 53.1 bits (126), Expect = 3e-07 Identities = 39/131 (29%), Positives = 73/131 (55%), Gaps = 9/131 (6%) Frame = +3 Query: 78 IIGEGGYGRVYRGI-VQDG----VEVAVK-LLTGKHQNRDREFIAEVEMLSRLHHRNLVK 239 ++G G +GRVY+G+ V +G + VA+K LL EF+ E +++ H NL+K Sbjct: 943 VLGMGAFGRVYKGVWVPEGENVKIPVAIKELLKSTGAESSEEFLREAYIMASEEHVNLLK 1002 Query: 240 MIGICIERRTRCLVFELVPNGSVESHLHGS-DKIYGP--LDFDTRMKIALGAARGLAYLH 410 ++ +C+ + L+ +L+P G + ++ + DKI L++ T++ A+G++YL Sbjct: 1003 LLAVCMSSQ-MMLITQLMPLGCLLDYVRNNRDKIGSKALLNWSTQI------AKGMSYLE 1055 Query: 411 EDANPHVIHRD 443 E ++HRD Sbjct: 1056 E---KRLVHRD 1063
>LCK_AOTNA (Q5PXS1) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) Length = 508 Score = 53.1 bits (126), Expect = 3e-07 Identities = 37/125 (29%), Positives = 63/125 (50%) Frame = +3 Query: 81 IGEGGYGRVYRGIVQDGVEVAVKLLTGKHQNRDREFIAEVEMLSRLHHRNLVKMIGICIE 260 +G G +G V+ G D +VAVK L + D F+AE ++ +L H+ LV++ + + Sbjct: 250 LGAGQFGEVWMGYYNDHTKVAVKSLKQGSMSPD-AFLAEANLMKQLQHQRLVRLYAV-VT 307 Query: 261 RRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHR 440 + ++ E + NGS+ L I L + + +A A G+A++ E + IHR Sbjct: 308 QEPIYIITEYMENGSLVDFLKTPSGI--KLTINKLLDMAAQIAEGMAFIEE---RNYIHR 362 Query: 441 DFRLA 455 D R A Sbjct: 363 DLRAA 367
>JAK1_HUMAN (P23458) Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1)| (JAK-1) Length = 1142 Score = 53.1 bits (126), Expect = 3e-07 Identities = 41/130 (31%), Positives = 66/130 (50%), Gaps = 7/130 (5%) Frame = +3 Query: 75 RIIGEGGYGRV----YRGIVQDGVEVAVKLLTGKHQ-NRDREFIAEVEMLSRLHHRNLVK 239 R +GEG +G+V Y G +VAVK L + N + E+E+L L+H N+VK Sbjct: 868 RDLGEGHFGKVELCRYDPEDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVK 927 Query: 240 MIGICIERRTR--CLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHE 413 GIC E L+ E +P+GS++ +L K ++ ++K A+ +G+ YL Sbjct: 928 YKGICTEDGGNGIKLIMEFLPSGSLKEYL---PKNKNKINLKQQLKYAVQICKGMDYL-- 982 Query: 414 DANPHVIHRD 443 + +HRD Sbjct: 983 -GSRQYVHRD 991
>EPHA3_BRARE (O13146) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ZEK1) (EPH-like kinase 1) Length = 981 Score = 53.1 bits (126), Expect = 3e-07 Identities = 35/128 (27%), Positives = 67/128 (52%), Gaps = 5/128 (3%) Frame = +3 Query: 75 RIIGEGGYGRVYRGIVQ----DGVEVAVKLL-TGKHQNRDREFIAEVEMLSRLHHRNLVK 239 R+IG G +G V G ++ ++VA+K L G +++ R+F++E ++ + H N+++ Sbjct: 630 RVIGAGEFGEVCSGRLRLPSKREIQVAIKSLKAGYSEHQRRDFLSEASIMGQFDHPNIIR 689 Query: 240 MIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDA 419 + G+ + +V E + NGS+++ L D G + + G A G+ YL E Sbjct: 690 LEGVVTRCKPVMIVTEYMENGSLDTFLKKHD---GQFTVIQLLGMLRGIAAGMQYLSE-- 744 Query: 420 NPHVIHRD 443 + +HRD Sbjct: 745 -MNYVHRD 751
>LIMK1_RAT (P53669) LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1)| Length = 647 Score = 52.8 bits (125), Expect = 4e-07 Identities = 34/123 (27%), Positives = 63/123 (51%), Gaps = 1/123 (0%) Frame = +3 Query: 78 IIGEGGYGRVYRGIVQDGVEVAV-KLLTGKHQNRDREFIAEVEMLSRLHHRNLVKMIGIC 254 ++G+G +G+ + ++ EV V K L + R F+ EV+++ L H N++K IG+ Sbjct: 344 VLGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGVL 403 Query: 255 IERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVI 434 + + + E + G++ + D Y + R+ A A G+AYLH + ++I Sbjct: 404 YKDKRLNFITEYIKGGTLRGIIKSMDSQY---PWSQRVSFAKDIASGMAYLH---SMNII 457 Query: 435 HRD 443 HRD Sbjct: 458 HRD 460
>LIMK1_MOUSE (P53668) LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (KIZ-1)| Length = 647 Score = 52.8 bits (125), Expect = 4e-07 Identities = 34/123 (27%), Positives = 63/123 (51%), Gaps = 1/123 (0%) Frame = +3 Query: 78 IIGEGGYGRVYRGIVQDGVEVAV-KLLTGKHQNRDREFIAEVEMLSRLHHRNLVKMIGIC 254 ++G+G +G+ + ++ EV V K L + R F+ EV+++ L H N++K IG+ Sbjct: 344 VLGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGVL 403 Query: 255 IERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVI 434 + + + E + G++ + D Y + R+ A A G+AYLH + ++I Sbjct: 404 YKDKRLNFITEYIKGGTLRGIIKNMDSQY---PWSQRVSFAKDIASGMAYLH---SMNII 457 Query: 435 HRD 443 HRD Sbjct: 458 HRD 460
>LIMK1_HUMAN (P53667) LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1)| Length = 647 Score = 52.8 bits (125), Expect = 4e-07 Identities = 34/123 (27%), Positives = 63/123 (51%), Gaps = 1/123 (0%) Frame = +3 Query: 78 IIGEGGYGRVYRGIVQDGVEVAV-KLLTGKHQNRDREFIAEVEMLSRLHHRNLVKMIGIC 254 ++G+G +G+ + ++ EV V K L + R F+ EV+++ L H N++K IG+ Sbjct: 344 VLGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGVL 403 Query: 255 IERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVI 434 + + + E + G++ + D Y + R+ A A G+AYLH + ++I Sbjct: 404 YKDKRLNFITEYIKGGTLRGIIKSMDSQY---PWSQRVSFAKDIASGMAYLH---SMNII 457 Query: 435 HRD 443 HRD Sbjct: 458 HRD 460
>EPHA8_MOUSE (O09127) Ephrin type-A receptor 8 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) Length = 1004 Score = 52.8 bits (125), Expect = 4e-07 Identities = 40/149 (26%), Positives = 65/149 (43%), Gaps = 11/149 (7%) Frame = +3 Query: 45 EKATDKFSFNRIIGEGGYGRVYRGIVQ----DGVEVAVKLLTGKHQNRDRE-FIAEVEML 209 E + +IIG G G V G +Q V VA+K L + R R+ F++E ++ Sbjct: 628 EIEASRIHIEKIIGSGESGEVCYGRLQVPGQRDVPVAIKALKAGYTERQRQDFLSEAAIM 687 Query: 210 SRLHHRNLVKMIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAA 389 + H N++++ G+ R +V E + NGS+++ L D G + + G Sbjct: 688 GQFDHPNIIRLEGVVTRGRLAMIVTEYMENGSLDAFLRTHD---GQFTIVQLVGMLRGVG 744 Query: 390 RG------LAYLHEDANPHVIHRDFRLAC 458 G L Y+H D + D RL C Sbjct: 745 AGMRYLSDLGYIHRDLAARNVLVDGRLVC 773
>MERTK_MOUSE (Q60805) Proto-oncogene tyrosine-protein kinase MER precursor (EC| 2.7.10.1) (C-mer) (Receptor tyrosine kinase MerTK) Length = 994 Score = 52.8 bits (125), Expect = 4e-07 Identities = 36/136 (26%), Positives = 69/136 (50%), Gaps = 13/136 (9%) Frame = +3 Query: 75 RIIGEGGYGRVYRGIV--QDGVEVAVKLLTGKHQNRDR----EFIAEVEMLSRLHHRNLV 236 +++GEG +G V G + +DG V + T K N + EF++E + +H N++ Sbjct: 586 KVLGEGEFGSVMEGNLKQEDGTSQKVAVKTMKLDNFSQREIEEFLSEAACMKDFNHPNVI 645 Query: 237 KMIGICIERRTR-----CLVFELVPNGSVESHLHGSDKIYGP--LDFDTRMKIALGAARG 395 +++G+CIE ++ ++ + G + + L S GP + T +K + A+G Sbjct: 646 RLLGVCIELSSQGIPKPMVILPFMKYGDLHTFLLYSRLNTGPKYIHLQTLLKFMMDIAQG 705 Query: 396 LAYLHEDANPHVIHRD 443 + YL +N + +HRD Sbjct: 706 MEYL---SNRNFLHRD 718
>IGF1R_XENLA (O73798) Insulin-like growth factor 1 receptor precursor (EC| 2.7.10.1) (xIGF-1R) (xIGFR) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain] Length = 1358 Score = 52.8 bits (125), Expect = 4e-07 Identities = 37/146 (25%), Positives = 75/146 (51%), Gaps = 13/146 (8%) Frame = +3 Query: 45 EKATDKFSFNRIIGEGGYGRVY----RGIVQDGVE--VAVKLLTGKHQNRDR-EFIAEVE 203 E +K + NR +G+G +G VY +G+V+D E VA+K + R+R EF+ E Sbjct: 989 EVPREKITMNRELGQGSFGMVYEGIAKGVVKDEAETKVAIKTVNEAASMRERIEFLNEAS 1048 Query: 204 MLSRLHHRNLVKMIGICIERRTRCLVFELVPNGSVESHLHG------SDKIYGPLDFDTR 365 ++ + ++V+++G+ + + ++ EL+ G ++S+L S+ Sbjct: 1049 VMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPDTESNSGQPTPSLKKM 1108 Query: 366 MKIALGAARGLAYLHEDANPHVIHRD 443 +++A A G++YL+ + +HRD Sbjct: 1109 IQMAGEIADGMSYLNAN---KFVHRD 1131
>IPL1_ASHGO (Q755C4) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) Length = 367 Score = 52.4 bits (124), Expect = 6e-07 Identities = 37/133 (27%), Positives = 63/133 (47%), Gaps = 4/133 (3%) Frame = +3 Query: 63 FSFNRIIGEGGYGRVYR-GIVQDGVEVAVKLLTGK---HQNRDREFIAEVEMLSRLHHRN 230 F +++G+G +GRVY ++ G A+K + K N +++F EVE+ S L H N Sbjct: 109 FEIGKVLGKGKFGRVYCVRHIESGFVCALKAMEKKDIIQYNIEKQFRREVEIQSSLRHPN 168 Query: 231 LVKMIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLH 410 L ++ G + + L+ E + NG + HL G + A L Y+H Sbjct: 169 LTQLYGYFHDEKRVYLLMEYLVNGELYKHLKGRSHFNDVV----ASYYVYQMADALDYMH 224 Query: 411 EDANPHVIHRDFR 449 E +++HRD + Sbjct: 225 E---RNILHRDIK 234
>EPHB4_HUMAN (P54760) Ephrin type-B receptor 4 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor HTK) Length = 987 Score = 52.4 bits (124), Expect = 6e-07 Identities = 36/127 (28%), Positives = 64/127 (50%), Gaps = 5/127 (3%) Frame = +3 Query: 78 IIGEGGYGRVYRGIVQDGVE----VAVKLLTGKHQNRDR-EFIAEVEMLSRLHHRNLVKM 242 +IG G +G V RG ++ + VA+K L G + R R EF++E ++ + H N++++ Sbjct: 620 VIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTERQRREFLSEASIMGQFEHPNIIRL 679 Query: 243 IGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDAN 422 G+ ++ E + NG+++S L +D G + + G A G+ YL A Sbjct: 680 EGVVTNSMPVMILTEFMENGALDSFLRLND---GQFTVIQLVGMLRGIASGMRYL---AE 733 Query: 423 PHVIHRD 443 +HRD Sbjct: 734 MSYVHRD 740
>CC2H1_TRYBB (P38973) Cell division control protein 2 homolog 1 (EC 2.7.11.22)| Length = 301 Score = 52.4 bits (124), Expect = 6e-07 Identities = 39/126 (30%), Positives = 62/126 (49%), Gaps = 3/126 (2%) Frame = +3 Query: 81 IGEGGYGRVYRGI-VQDGVEVAVKL--LTGKHQNRDREFIAEVEMLSRLHHRNLVKMIGI 251 IGEG YG V+R V G VAVK L + + I E+ +L L H N+V+++ + Sbjct: 11 IGEGSYGVVFRARDVTTGTIVAVKRIRLEKEEEGVPCTAIREISILKELRHENIVRLLDV 70 Query: 252 CIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHV 431 C + LVFE + ++ ++ D + G LD T + G+ + HE +V Sbjct: 71 CHSEKRLTLVFECM-EMDLKKYM---DHVGGDLDAGTIQEFMRSLLSGVRFCHE---RNV 123 Query: 432 IHRDFR 449 +HRD + Sbjct: 124 LHRDLK 129
>FGFR4_RAT (Q498D6) Fibroblast growth factor receptor 4 precursor (EC| 2.7.10.1) (FGFR-4) Length = 800 Score = 52.4 bits (124), Expect = 6e-07 Identities = 39/151 (25%), Positives = 66/151 (43%), Gaps = 22/151 (14%) Frame = +3 Query: 57 DKFSFNRIIGEGGYGRVYRGIV--------QDGVEVAVKLLTGKHQNRD-REFIAEVEML 209 D+ + +GEG +G+V R VAVK+L ++D + I+E+EM+ Sbjct: 463 DRLVLGKPLGEGCFGQVVRAEALGMDSSRPDQTSTVAVKMLKDNASDKDLADLISEMEMM 522 Query: 210 SRL-HHRNLVKMIGICIERRTRCLVFELVPNGSVESHLH------------GSDKIYGPL 350 + H+N++ ++G+C + ++ E G++ L G GPL Sbjct: 523 KLIGRHKNIINLLGVCTQEGPLYVIVEYAAKGNLREFLRARRPPGPDLSPDGPRSSEGPL 582 Query: 351 DFDTRMKIALGAARGLAYLHEDANPHVIHRD 443 F + A ARG+ YL + IHRD Sbjct: 583 SFPALVSCAYQVARGMQYLE---SRKCIHRD 610
>TIE2_BRARE (O73791) Tyrosine-protein kinase receptor Tie-2 precursor (EC| 2.7.10.1) Length = 1116 Score = 52.4 bits (124), Expect = 6e-07 Identities = 41/142 (28%), Positives = 68/142 (47%), Gaps = 17/142 (11%) Frame = +3 Query: 69 FNRIIGEGGYGRVYRG-IVQDGV--EVAVKLLTG-KHQNRDREFIAEVEMLSRLH-HRNL 233 F ++GEG +G+V + I +DG+ + AVK + Q+ R+F E+E+L RL H+N+ Sbjct: 818 FQDVLGEGNFGQVLKARIRKDGLRMDAAVKRMKDYASQDDHRDFAGELEVLCRLGPHKNI 877 Query: 234 VKMIGICIERRTRCLVFELVPNGSVESHLHGS------------DKIYGPLDFDTRMKIA 377 + ++G C R L E P+G++ L S + L + + Sbjct: 878 IHLLGACEHRGYLYLAIEFAPHGNLLDFLRKSRVLETDPAFAIAHRTASTLSSQQLLAFS 937 Query: 378 LGAARGLAYLHEDANPHVIHRD 443 ARG++YL + IHRD Sbjct: 938 ADVARGMSYL---SQKQFIHRD 956
>TAOK2_RAT (Q9JLS3) Serine/threonine-protein kinase TAO2 (EC 2.7.11.1)| (Thousand and one amino acid protein 2) Length = 1235 Score = 52.0 bits (123), Expect = 8e-07 Identities = 50/151 (33%), Positives = 70/151 (46%), Gaps = 4/151 (2%) Frame = +3 Query: 9 PPTVKTFSISELEKATDKFSFNRIIGEGGYGRVYRGI-VQDGVEVAVKLLT--GKHQNRD 179 P + F + EK FS R IG G +G VY V++ VA+K ++ GK N Sbjct: 13 PDVAELFFKDDPEKL---FSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEK 69 Query: 180 -REFIAEVEMLSRLHHRNLVKMIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDF 356 ++ I EV L +L H N ++ G + T LV E GS L K PL Sbjct: 70 WQDIIKEVRFLQKLRHPNTIQYRGCYLREHTAWLVMEYCL-GSASDLLEVHKK---PLQE 125 Query: 357 DTRMKIALGAARGLAYLHEDANPHVIHRDFR 449 + GA +GLAYLH + ++IHRD + Sbjct: 126 VEIAAVTHGALQGLAYLH---SHNMIHRDVK 153
>TAOK2_HUMAN (Q9UL54) Serine/threonine-protein kinase TAO2 (EC 2.7.11.1)| (Thousand and one amino acid protein 2) (Prostate-derived STE20-like kinase 1) (PSK-1) (Kinase from chicken homolog C) (hKFC-C) Length = 1235 Score = 52.0 bits (123), Expect = 8e-07 Identities = 50/151 (33%), Positives = 70/151 (46%), Gaps = 4/151 (2%) Frame = +3 Query: 9 PPTVKTFSISELEKATDKFSFNRIIGEGGYGRVYRGI-VQDGVEVAVKLLT--GKHQNRD 179 P + F + EK FS R IG G +G VY V++ VA+K ++ GK N Sbjct: 13 PDVAELFFKDDPEKL---FSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEK 69 Query: 180 -REFIAEVEMLSRLHHRNLVKMIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDF 356 ++ I EV L +L H N ++ G + T LV E GS L K PL Sbjct: 70 WQDIIKEVRFLQKLRHPNTIQYRGCYLREHTAWLVMEYCL-GSASDLLEVHKK---PLQE 125 Query: 357 DTRMKIALGAARGLAYLHEDANPHVIHRDFR 449 + GA +GLAYLH + ++IHRD + Sbjct: 126 VEIAAVTHGALQGLAYLH---SHNMIHRDVK 153
>TAOK2_MOUSE (Q6ZQ29) Serine/threonine-protein kinase TAO2 (EC 2.7.11.1)| (Thousand and one amino acid protein 2) Length = 1055 Score = 52.0 bits (123), Expect = 8e-07 Identities = 50/151 (33%), Positives = 70/151 (46%), Gaps = 4/151 (2%) Frame = +3 Query: 9 PPTVKTFSISELEKATDKFSFNRIIGEGGYGRVYRGI-VQDGVEVAVKLLT--GKHQNRD 179 P + F + EK FS R IG G +G VY V++ VA+K ++ GK N Sbjct: 13 PDVAELFFKDDPEKL---FSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEK 69 Query: 180 -REFIAEVEMLSRLHHRNLVKMIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDF 356 ++ I EV L +L H N ++ G + T LV E GS L K PL Sbjct: 70 WQDIIKEVRFLQKLRHPNTIQYRGCYLREHTAWLVMEYCL-GSASDLLEVHKK---PLQE 125 Query: 357 DTRMKIALGAARGLAYLHEDANPHVIHRDFR 449 + GA +GLAYLH + ++IHRD + Sbjct: 126 VEIAAVTHGALQGLAYLH---SHNMIHRDVK 153
>EPHB5_CHICK (Q07497) Ephrin type-B receptor 5 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase CEK9) Length = 1002 Score = 52.0 bits (123), Expect = 8e-07 Identities = 39/145 (26%), Positives = 71/145 (48%), Gaps = 7/145 (4%) Frame = +3 Query: 30 SISELEKATDK--FSFNRIIGEGGYGRVYRGIVQDGVE----VAVKLL-TGKHQNRDREF 188 +I E K D +IG G +G V G ++ + VA+K L +G + REF Sbjct: 624 AIREFAKEIDVSFIKIEEVIGSGEFGEVCFGRLKHPGKREYTVAIKTLKSGYTDEQRREF 683 Query: 189 IAEVEMLSRLHHRNLVKMIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRM 368 ++E ++ + H N++ + G+ + R +V E + NGS++S L + + L + Sbjct: 684 LSEASIMGQFEHPNVIHLEGVVTKSRPVMIVTEFMENGSLDSFLRQKEGQFSVLQLVGML 743 Query: 369 KIALGAARGLAYLHEDANPHVIHRD 443 + G A G+ YL ++ + +HRD Sbjct: 744 R---GIAAGMRYL---SDMNYVHRD 762
>TEC_HUMAN (P42680) Tyrosine-protein kinase Tec (EC 2.7.10.2)| Length = 631 Score = 52.0 bits (123), Expect = 8e-07 Identities = 37/144 (25%), Positives = 69/144 (47%) Frame = +3 Query: 12 PTVKTFSISELEKATDKFSFNRIIGEGGYGRVYRGIVQDGVEVAVKLLTGKHQNRDREFI 191 PT FS + E + +F R +G G +G V G + +VA+K + + + +FI Sbjct: 353 PTTAGFSYEKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIR-EGAMCEEDFI 411 Query: 192 AEVEMLSRLHHRNLVKMIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMK 371 E +++ +L H LV++ G+C +++ +V E + G + + L + G D + Sbjct: 412 EEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLR---QRQGHFSRDVLLS 468 Query: 372 IALGAARGLAYLHEDANPHVIHRD 443 + G+ YL ++ IHRD Sbjct: 469 MCQDVCEGMEYLERNS---FIHRD 489
>DDR2_MOUSE (Q62371) Discoidin domain-containing receptor 2 precursor (EC| 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen) Length = 854 Score = 52.0 bits (123), Expect = 8e-07 Identities = 42/175 (24%), Positives = 81/175 (46%), Gaps = 29/175 (16%) Frame = +3 Query: 6 CPPTVKTFSISELEKATDKF-----SFNRIIGEGGYGRVYRGIVQDGVE----------- 137 C P V +S + A ++F +F +GEG +G V+ V+ G+E Sbjct: 539 CVPAVTMDLLSGKDVAVEEFPRKLLAFKEKLGEGQFGEVHLCEVE-GMEKFKDKDFALDV 597 Query: 138 -------VAVKLLTGK-HQNRDREFIAEVEMLSRLHHRNLVKMIGICIERRTRCLVFELV 293 VAVK+L ++N +F+ E++++SRL N+++++ +CI C++ E + Sbjct: 598 SANQPVLVAVKMLRADANKNARNDFLKEIKIMSRLKDPNIIRLLAVCITEDPLCMITEYM 657 Query: 294 PNGSVESHLHGSDKIY-----GPLDFDTRMKIALGAARGLAYLHEDANPHVIHRD 443 NG + L + + + + +A A G+ YL ++ + +HRD Sbjct: 658 ENGDLNQFLSRHEPLSSCSSDATVSYANLKFMATQIASGMKYL---SSLNFVHRD 709
>M4K4_MOUSE (P97820) Mitogen-activated protein kinase kinase kinase kinase 4| (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase) Length = 1233 Score = 52.0 bits (123), Expect = 8e-07 Identities = 43/146 (29%), Positives = 65/146 (44%), Gaps = 7/146 (4%) Frame = +3 Query: 33 ISELEKATDKFSFNRIIGEGGYGRVYRGIVQDGVEVAVKLLTGKHQNRDREFIAEVEMLS 212 +S L F ++G G YG+VY+G V A+K++ ++ + E E+ ML Sbjct: 15 LSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTVTAAIKVM-DVTEDEEEEITLEINMLK 73 Query: 213 RL-HHRNLVKMIGICIERR------TRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMK 371 + HHRN+ G I++ LV E GS+ + + L D Sbjct: 74 KYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKG--NTLKEDWIAY 131 Query: 372 IALGAARGLAYLHEDANPHVIHRDFR 449 I+ RGLA+LH HVIHRD + Sbjct: 132 ISREILRGLAHLHIH---HVIHRDIK 154
>EPHA7_MOUSE (Q61772) Ephrin type-A receptor 7 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Embryonic brain kinase) (EBK) (Developmental kinase 1) (MDK-1) Length = 998 Score = 52.0 bits (123), Expect = 8e-07 Identities = 37/128 (28%), Positives = 63/128 (49%), Gaps = 5/128 (3%) Frame = +3 Query: 75 RIIGEGGYGRVYRGIV----QDGVEVAVKLL-TGKHQNRDREFIAEVEMLSRLHHRNLVK 239 R+IG G +G V G + Q V VA+K L G + + R+F+ E ++ + H N+V Sbjct: 637 RVIGAGEFGEVCSGRLKLPGQRDVAVAIKTLKVGYTEKQRRDFLCEASIMGQFDHPNVVH 696 Query: 240 MIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDA 419 + G+ + +V E + NG++++ L D G + + G A G+ YL A Sbjct: 697 LEGVVTRGKPVMIVIEFMENGALDAFLRKHD---GQFTVIQLVGMLRGIAAGMRYL---A 750 Query: 420 NPHVIHRD 443 + +HRD Sbjct: 751 DMGYVHRD 758
>EPHA8_HUMAN (P29322) Ephrin type-A receptor 8 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) (HEK3) Length = 1005 Score = 51.6 bits (122), Expect = 1e-06 Identities = 37/138 (26%), Positives = 64/138 (46%), Gaps = 5/138 (3%) Frame = +3 Query: 45 EKATDKFSFNRIIGEGGYGRVYRGIV----QDGVEVAVKLLTGKHQNRDR-EFIAEVEML 209 E + +IIG G G V G + Q V VA+K L + R R +F++E ++ Sbjct: 629 EIEASRIHIEKIIGSGDSGEVCYGRLRVPGQRDVPVAIKALKAGYTERQRRDFLSEASIM 688 Query: 210 SRLHHRNLVKMIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAA 389 + H N++++ G+ R +V E + NGS+++ L D G + + G Sbjct: 689 GQFDHPNIIRLEGVVTRGRLAMIVTEYMENGSLDTFLRTHD---GQFTIMQLVGMLRGVG 745 Query: 390 RGLAYLHEDANPHVIHRD 443 G+ YL ++ +HRD Sbjct: 746 AGMRYL---SDLGYVHRD 760
>TEC_MOUSE (P24604) Tyrosine-protein kinase Tec (EC 2.7.10.2)| Length = 630 Score = 51.6 bits (122), Expect = 1e-06 Identities = 37/144 (25%), Positives = 69/144 (47%) Frame = +3 Query: 12 PTVKTFSISELEKATDKFSFNRIIGEGGYGRVYRGIVQDGVEVAVKLLTGKHQNRDREFI 191 PT FS + E + +F R +G G +G V G + +VA+K + + + +FI Sbjct: 352 PTTAGFSYDKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIR-EGAMCEEDFI 410 Query: 192 AEVEMLSRLHHRNLVKMIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMK 371 E +++ +L H LV++ G+C +++ +V E + G + + L + G D + Sbjct: 411 EEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLR---QRQGHFSRDMLLS 467 Query: 372 IALGAARGLAYLHEDANPHVIHRD 443 + G+ YL ++ IHRD Sbjct: 468 MCQDVCEGMEYLERNS---FIHRD 488
>EPHB4_MOUSE (P54761) Ephrin type-B receptor 4 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor MDK-2) (Developmental kinase 2) (Tyrosine kinase MYK-1) Length = 987 Score = 51.6 bits (122), Expect = 1e-06 Identities = 36/127 (28%), Positives = 64/127 (50%), Gaps = 5/127 (3%) Frame = +3 Query: 78 IIGEGGYGRVYRGIVQDGVE----VAVKLLTGKHQNRDR-EFIAEVEMLSRLHHRNLVKM 242 +IG G +G V RG ++ + VA+K L G + R R EF++E ++ + H N++++ Sbjct: 620 VIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTERQRREFLSEASIMGQFEHPNIIRL 679 Query: 243 IGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDAN 422 G+ ++ E + NG+++S L +D G + + G A G+ YL A Sbjct: 680 EGVVTNSVPVMILTEFMENGALDSFLRLND---GQFTVIQLVGMLRGIASGMRYL---AE 733 Query: 423 PHVIHRD 443 +HRD Sbjct: 734 MSYVHRD 740
>CRK1_LEIME (Q06309) Cell division protein kinase 2 homolog CRK1 (EC 2.7.11.23)| Length = 301 Score = 51.6 bits (122), Expect = 1e-06 Identities = 39/135 (28%), Positives = 64/135 (47%), Gaps = 3/135 (2%) Frame = +3 Query: 54 TDKFSFNRIIGEGGYGRVYRGI-VQDGVEVAVKL--LTGKHQNRDREFIAEVEMLSRLHH 224 T ++ IGEG YG VY+ VA+K L + + I E+ +L L H Sbjct: 2 TSRYERQEKIGEGTYGVVYKARDTSTAATVALKRIRLDSEEEGVPCTAIREISLLKELRH 61 Query: 225 RNLVKMIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAY 404 N+VK++ +C +VFE + + ++ +L D+ G LD T RG+A+ Sbjct: 62 ENIVKLLDVCHSEHRLTIVFEYL-DLDLKKYL---DRENGNLDAATIQHFMRDLLRGVAF 117 Query: 405 LHEDANPHVIHRDFR 449 H+ + V+HRD + Sbjct: 118 CHQRS---VLHRDLK 129
>M3K3_HUMAN (Q99759) Mitogen-activated protein kinase kinase kinase 3 (EC| 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3) Length = 626 Score = 51.6 bits (122), Expect = 1e-06 Identities = 39/133 (29%), Positives = 65/133 (48%), Gaps = 8/133 (6%) Frame = +3 Query: 75 RIIGEGGYGRVYRGI-VQDGVEVAVKLLTGKHQNRD--REFIA---EVEMLSRLHHRNLV 236 +++G+G +GRVY V G E+A K + + + +E A E+++L L H +V Sbjct: 366 KLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQHERIV 425 Query: 237 KMIGICIER--RTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLH 410 + G +R +T + E +P GSV+ L K YG L K G++YLH Sbjct: 426 QYYGCLRDRAEKTLTIFMEYMPGGSVKDQL----KAYGALTESVTRKYTRQILEGMSYLH 481 Query: 411 EDANPHVIHRDFR 449 + ++HRD + Sbjct: 482 SNM---IVHRDIK 491
>LCK_SAISC (Q95KR7) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) Length = 508 Score = 51.6 bits (122), Expect = 1e-06 Identities = 37/125 (29%), Positives = 61/125 (48%) Frame = +3 Query: 81 IGEGGYGRVYRGIVQDGVEVAVKLLTGKHQNRDREFIAEVEMLSRLHHRNLVKMIGICIE 260 +G G +G V+ G + +VAVK L + D F+AE ++ +L H+ LV++ + E Sbjct: 250 LGAGQFGEVWMGYYNEHTKVAVKSLKQGSMSPDA-FLAEANLMKQLQHKRLVRLYAVVTE 308 Query: 261 RRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHR 440 ++ E + NGS+ L I L + + +A G+A+L E + IHR Sbjct: 309 EPI-YIITEYMENGSLVDFLKTPSGI--KLTINKLLDMAAQIVEGMAFLEE---RNYIHR 362 Query: 441 DFRLA 455 D R A Sbjct: 363 DLRAA 367
>BYR2_SCHPO (P28829) Protein kinase byr2 (EC 2.7.11.25) (Protein kinase ste8)| (MAPK kinase kinase) (MAPKKK) Length = 659 Score = 51.6 bits (122), Expect = 1e-06 Identities = 43/160 (26%), Positives = 71/160 (44%), Gaps = 13/160 (8%) Frame = +3 Query: 9 PPTVKTFSISELEKATD----KFSFNRIIGEGGYGRVYRGI-VQDGVEVAVK--LLTGKH 167 P + + + LE+ TD K+ +IG G +G+VY G+ G +AVK +L Sbjct: 372 PTSTTSEDTNTLEEDTDDQSIKWIRGALIGSGSFGQVYLGMNASSGELMAVKQVILDSVS 431 Query: 168 QNRDRE------FIAEVEMLSRLHHRNLVKMIGICIERRTRCLVFELVPNGSVESHLHGS 329 +++DR E+ +L L H ++V+ +G + + E VP GSV L Sbjct: 432 ESKDRHAKLLDALAGEIALLQELSHEHIVQYLGSNLNSDHLNIFLEYVPGGSVAGLL--- 488 Query: 330 DKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRDFR 449 +YG + +GL YLH ++HRD + Sbjct: 489 -TMYGSFEETLVKNFIKQTLKGLEYLHSRG---IVHRDIK 524
>JAK3_HUMAN (P52333) Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase| 3) (JAK-3) (Leukocyte janus kinase) (L-JAK) Length = 1124 Score = 51.2 bits (121), Expect = 1e-06 Identities = 33/131 (25%), Positives = 66/131 (50%), Gaps = 7/131 (5%) Frame = +3 Query: 57 DKFSFNRIIGEGGYGRVYRGI---VQDG----VEVAVKLLTGKHQNRDREFIAEVEMLSR 215 D ++ +G G + ++YRG V DG EV +K++ KH+N F+ ++S+ Sbjct: 519 DSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQ 578 Query: 216 LHHRNLVKMIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARG 395 + +R+LV + G+C+ + +V E V G+++ +L + + ++++ A Sbjct: 579 VSYRHLVLLHGVCMAGDS-TMVQEFVHLGAIDMYLRKRGHL---VPASWKLQVVKQLAYA 634 Query: 396 LAYLHEDANPH 428 L YL + PH Sbjct: 635 LNYLEDKGLPH 645 Score = 38.5 bits (88), Expect = 0.009 Identities = 35/128 (27%), Positives = 60/128 (46%), Gaps = 7/128 (5%) Frame = +3 Query: 81 IGEGGYGRV----YRGIVQD-GVEVAVKLLTGKHQNRDREFIAEVEMLSRLHHRNLVKMI 245 +G+G +G V Y + + G VAVK L ++ R+F E+++L LH +VK Sbjct: 828 LGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYR 887 Query: 246 GICI--ERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDA 419 G+ R++ LV E +P+G + L + LD + + +G+ YL Sbjct: 888 GVSYGPGRQSLRLVMEYLPSGCLRDFL---QRHRARLDASRLLLYSSQICKGMEYL---G 941 Query: 420 NPHVIHRD 443 + +HRD Sbjct: 942 SRRCVHRD 949
>FGFR4_HUMAN (P22455) Fibroblast growth factor receptor 4 precursor (EC| 2.7.10.1) (FGFR-4) (CD334 antigen) Length = 802 Score = 51.2 bits (121), Expect = 1e-06 Identities = 37/151 (24%), Positives = 66/151 (43%), Gaps = 22/151 (14%) Frame = +3 Query: 57 DKFSFNRIIGEGGYGRVYRGIV--------QDGVEVAVKLLTGKHQNRD-REFIAEVEML 209 D+ + +GEG +G+V R VAVK+L ++D + ++E+E++ Sbjct: 465 DRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVM 524 Query: 210 SRL-HHRNLVKMIGICIERRTRCLVFELVPNGSVESHLH------------GSDKIYGPL 350 + H+N++ ++G+C + ++ E G++ L G GPL Sbjct: 525 KLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPL 584 Query: 351 DFDTRMKIALGAARGLAYLHEDANPHVIHRD 443 F + A ARG+ YL + IHRD Sbjct: 585 SFPVLVSCAYQVARGMQYLE---SRKCIHRD 612
>INSR_HUMAN (P06213) Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220| antigen) [Contains: Insulin receptor alpha subunit; Insulin receptor beta subunit] Length = 1382 Score = 51.2 bits (121), Expect = 1e-06 Identities = 38/148 (25%), Positives = 74/148 (50%), Gaps = 13/148 (8%) Frame = +3 Query: 39 ELEKATDKFSFNRIIGEGGYGRVYRGIVQDGVE------VAVKLLTGKHQNRDR-EFIAE 197 E E + +K + R +G+G +G VY G +D ++ VAVK + R+R EF+ E Sbjct: 1015 EWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNE 1074 Query: 198 VEMLSRLHHRNLVKMIGICIERRTRCLVFELVPNGSVESHLHG------SDKIYGPLDFD 359 ++ ++V+++G+ + + +V EL+ +G ++S+L ++ P Sbjct: 1075 ASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQ 1134 Query: 360 TRMKIALGAARGLAYLHEDANPHVIHRD 443 +++A A G+AYL+ +HRD Sbjct: 1135 EMIQMAAEIADGMAYLNA---KKFVHRD 1159
>CDKL2_MACFA (Q4R7T5) Cyclin-dependent kinase-like 2 (EC 2.7.11.22)| Length = 570 Score = 51.2 bits (121), Expect = 1e-06 Identities = 37/134 (27%), Positives = 67/134 (50%), Gaps = 3/134 (2%) Frame = +3 Query: 57 DKFSFNRIIGEGGYGRVYRGIVQD-GVEVAVKLLTGKHQNRDREFIA--EVEMLSRLHHR 227 +K+ ++GEG YG V + +D G VA+K ++ + IA E+++L +L H Sbjct: 2 EKYENLGLVGEGSYGMVVKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRHE 61 Query: 228 NLVKMIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYL 407 NLV ++ +C +++ LVFE V + + L + LD+ K G+ + Sbjct: 62 NLVNLLEVCKKKKRWYLVFEFVDH----TILDDLELFPNGLDYQVVQKYLFQIINGIGFC 117 Query: 408 HEDANPHVIHRDFR 449 H + ++IHRD + Sbjct: 118 H---SHNIIHRDIK 128
>INSR_RAT (P15127) Insulin receptor precursor (EC 2.7.10.1) (IR) [Contains:| Insulin receptor alpha subunit; Insulin receptor beta subunit] Length = 1383 Score = 51.2 bits (121), Expect = 1e-06 Identities = 38/148 (25%), Positives = 72/148 (48%), Gaps = 13/148 (8%) Frame = +3 Query: 39 ELEKATDKFSFNRIIGEGGYGRVYRGIVQDGVE------VAVKLLTGKHQNRDR-EFIAE 197 E E +K + R +G+G +G VY G +D ++ VAVK + R+R EF+ E Sbjct: 1016 EWEVPREKITLLRELGQGSFGMVYEGNAKDIIKGEVETRVAVKTVNESASLRERIEFLNE 1075 Query: 198 VEMLSRLHHRNLVKMIGICIERRTRCLVFELVPNGSVESHLHG------SDKIYGPLDFD 359 ++ ++V+++G+ + + +V EL+ +G ++SHL ++ P Sbjct: 1076 ASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSHLRSLRPDAENNPGRPPPTLQ 1135 Query: 360 TRMKIALGAARGLAYLHEDANPHVIHRD 443 +++ A G+AYL+ +HRD Sbjct: 1136 EMIQMTAEIADGMAYLNA---KKFVHRD 1160
>M3K5_HUMAN (Q99683) Mitogen-activated protein kinase kinase kinase 5 (EC| 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal-regulating kinase 1) (ASK-1) Length = 1374 Score = 51.2 bits (121), Expect = 1e-06 Identities = 36/128 (28%), Positives = 62/128 (48%), Gaps = 4/128 (3%) Frame = +3 Query: 78 IIGEGGYGRVYRGI-VQDGVEVAVKLLTGKHQNRDREFIAEVEMLSRLHHRNLVKMIGIC 254 ++G+G YG VY G + + V +A+K + + + E+ + L H+N+V+ +G Sbjct: 685 VLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKHLKHKNIVQYLGSF 744 Query: 255 IERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAAR---GLAYLHEDANP 425 E + E VP GS+ + L +GPL D I + GL YLH++ Sbjct: 745 SENGFIKIFMEQVPGGSLSALLRSK---WGPLK-DNEQTIGFYTKQILEGLKYLHDN--- 797 Query: 426 HVIHRDFR 449 ++HRD + Sbjct: 798 QIVHRDIK 805
>INSR_MOUSE (P15208) Insulin receptor precursor (EC 2.7.10.1) (IR) [Contains:| Insulin receptor alpha subunit; Insulin receptor beta subunit] Length = 1372 Score = 51.2 bits (121), Expect = 1e-06 Identities = 38/148 (25%), Positives = 72/148 (48%), Gaps = 13/148 (8%) Frame = +3 Query: 39 ELEKATDKFSFNRIIGEGGYGRVYRGIVQDGVE------VAVKLLTGKHQNRDR-EFIAE 197 E E +K + R +G+G +G VY G +D ++ VAVK + R+R EF+ E Sbjct: 1005 EWEVPREKITLLRELGQGSFGMVYEGNAKDIIKGEAETRVAVKTVNESASLRERIEFLNE 1064 Query: 198 VEMLSRLHHRNLVKMIGICIERRTRCLVFELVPNGSVESHLHG------SDKIYGPLDFD 359 ++ ++V+++G+ + + +V EL+ +G ++SHL ++ P Sbjct: 1065 ASVMKGFTCHHVVRLLGVVSKGQPMLVVMELMAHGDLKSHLRSLRPDAENNPGRPPPTLQ 1124 Query: 360 TRMKIALGAARGLAYLHEDANPHVIHRD 443 +++ A G+AYL+ +HRD Sbjct: 1125 EMIQMTAEIADGMAYLNA---KKFVHRD 1149
>ARK1_SCHPO (O59790) Serine/threonine-protein kinase ark1 (EC 2.7.11.1)| (Aurora-related kinase 1) Length = 355 Score = 51.2 bits (121), Expect = 1e-06 Identities = 36/133 (27%), Positives = 62/133 (46%), Gaps = 4/133 (3%) Frame = +3 Query: 63 FSFNRIIGEGGYGRVYRGIVQD-GVEVAVKLLTGKH---QNRDREFIAEVEMLSRLHHRN 230 F + +G+G +GRVY + G VA+K L +++ E+E+ S L H+N Sbjct: 89 FEIGKPLGKGKFGRVYLAKEKKTGFIVALKTLHKSELVQSKIEKQVRREIEIQSNLRHKN 148 Query: 231 LVKMIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLH 410 ++++ G + + L+ E G + HL + + + K A L+YLH Sbjct: 149 ILRLYGHFHDEKRIYLILEFAGRGELYQHLRRAKR----FSEEVASKYIFQMANALSYLH 204 Query: 411 EDANPHVIHRDFR 449 + HVIHRD + Sbjct: 205 K---KHVIHRDIK 214
>CDKL2_PONPY (Q5R754) Cyclin-dependent kinase-like 2 (EC 2.7.11.22)| Length = 493 Score = 51.2 bits (121), Expect = 1e-06 Identities = 37/134 (27%), Positives = 67/134 (50%), Gaps = 3/134 (2%) Frame = +3 Query: 57 DKFSFNRIIGEGGYGRVYRGIVQD-GVEVAVKLLTGKHQNRDREFIA--EVEMLSRLHHR 227 +K+ ++GEG YG V + +D G VA+K ++ + IA E+++L +L H Sbjct: 2 EKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRHE 61 Query: 228 NLVKMIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYL 407 NLV ++ +C +++ LVFE V + + L + LD+ K G+ + Sbjct: 62 NLVNLLEVCKKKKRWYLVFEFVDH----TILDDLELFPNGLDYQVVQKYLFQIINGIGFC 117 Query: 408 HEDANPHVIHRDFR 449 H + ++IHRD + Sbjct: 118 H---SHNIIHRDIK 128
>CDKL2_HUMAN (Q92772) Cyclin-dependent kinase-like 2 (EC 2.7.11.22)| (Serine/threonine-protein kinase KKIAMRE) (Protein kinase p56 KKIAMRE) Length = 493 Score = 51.2 bits (121), Expect = 1e-06 Identities = 37/134 (27%), Positives = 67/134 (50%), Gaps = 3/134 (2%) Frame = +3 Query: 57 DKFSFNRIIGEGGYGRVYRGIVQD-GVEVAVKLLTGKHQNRDREFIA--EVEMLSRLHHR 227 +K+ ++GEG YG V + +D G VA+K ++ + IA E+++L +L H Sbjct: 2 EKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRHE 61 Query: 228 NLVKMIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYL 407 NLV ++ +C +++ LVFE V + + L + LD+ K G+ + Sbjct: 62 NLVNLLEVCKKKKRWYLVFEFVDH----TILDDLELFPNGLDYQVVQKYLFQIINGIGFC 117 Query: 408 HEDANPHVIHRDFR 449 H + ++IHRD + Sbjct: 118 H---SHNIIHRDIK 128
>M3K5_MOUSE (O35099) Mitogen-activated protein kinase kinase kinase 5 (EC| 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal-regulating kinase 1) (ASK-1) Length = 1380 Score = 51.2 bits (121), Expect = 1e-06 Identities = 36/128 (28%), Positives = 62/128 (48%), Gaps = 4/128 (3%) Frame = +3 Query: 78 IIGEGGYGRVYRGI-VQDGVEVAVKLLTGKHQNRDREFIAEVEMLSRLHHRNLVKMIGIC 254 ++G+G YG VY G + + V +A+K + + + E+ + L H+N+V+ +G Sbjct: 692 VLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKHLKHKNIVQYLGSF 751 Query: 255 IERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAAR---GLAYLHEDANP 425 E + E VP GS+ + L +GPL D I + GL YLH++ Sbjct: 752 SENGFIKIFMEQVPGGSLSALLRSK---WGPLK-DNEQTIGFYTKQILEGLKYLHDN--- 804 Query: 426 HVIHRDFR 449 ++HRD + Sbjct: 805 QIVHRDIK 812
>EPHB3_HUMAN (P54753) Ephrin type-B receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor HEK-2) Length = 998 Score = 51.2 bits (121), Expect = 1e-06 Identities = 37/127 (29%), Positives = 67/127 (52%), Gaps = 5/127 (3%) Frame = +3 Query: 78 IIGEGGYGRVYRG-IVQDG---VEVAVKLL-TGKHQNRDREFIAEVEMLSRLHHRNLVKM 242 +IG G +G V RG + Q G V VA+K L G + + R+F++E ++ + H N++++ Sbjct: 638 VIGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGYTERQRRDFLSEASIMGQFDHPNIIRL 697 Query: 243 IGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDAN 422 G+ + R ++ E + N +++S L +D G + + G A G+ YL E Sbjct: 698 EGVVTKSRPVMILTEFMENCALDSFLRLND---GQFTVIQLVGMLRGIAAGMKYLSE--- 751 Query: 423 PHVIHRD 443 + +HRD Sbjct: 752 MNYVHRD 758
>M3K3_MOUSE (Q61084) Mitogen-activated protein kinase kinase kinase 3 (EC| 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3) Length = 626 Score = 50.8 bits (120), Expect = 2e-06 Identities = 39/133 (29%), Positives = 64/133 (48%), Gaps = 8/133 (6%) Frame = +3 Query: 75 RIIGEGGYGRVYRGI-VQDGVEVAVKLLTGKHQNRD--REFIA---EVEMLSRLHHRNLV 236 +++G+G +GRVY V G E+A K + + + +E A E+++L L H +V Sbjct: 366 KLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQHERIV 425 Query: 237 KMIGICIERRTRCLV--FELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLH 410 + G +R + L E +P GSV+ L K YG L K G++YLH Sbjct: 426 QYYGCLRDRAEKILTIFMEYMPGGSVKDQL----KAYGALTESVTRKYTRQILEGMSYLH 481 Query: 411 EDANPHVIHRDFR 449 + ++HRD + Sbjct: 482 SNM---IVHRDIK 491
>FES_MOUSE (P16879) Proto-oncogene tyrosine-protein kinase Fes/Fps (EC| 2.7.10.2) (C-Fes) Length = 820 Score = 50.8 bits (120), Expect = 2e-06 Identities = 37/123 (30%), Positives = 60/123 (48%), Gaps = 2/123 (1%) Frame = +3 Query: 81 IGEGGYGRVYRGIVQ-DGVEVAVKLLTGK-HQNRDREFIAEVEMLSRLHHRNLVKMIGIC 254 IG G +G V+ G ++ D VAVK + +F+ E +L + +H N+V++IG+C Sbjct: 565 IGRGNFGEVFSGRLRADNTPVAVKSCRETLPPDLKAKFLQEARILKQYNHPNIVRLIGVC 624 Query: 255 IERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVI 434 +++ +V ELV G + L L T +++ AA G+ YL I Sbjct: 625 TQKQPIYIVMELVQGGDFLTFLRTEG---ARLRVKTLLQMMGDAAAGMEYLESKC---CI 678 Query: 435 HRD 443 HRD Sbjct: 679 HRD 681
>JAK1_MOUSE (P52332) Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1)| (JAK-1) Length = 1153 Score = 50.8 bits (120), Expect = 2e-06 Identities = 40/131 (30%), Positives = 66/131 (50%), Gaps = 8/131 (6%) Frame = +3 Query: 75 RIIGEGGYGRVYRGIVQD-----GVEVAVKLLTGKHQ-NRDREFIAEVEMLSRLHHRNLV 236 R +GEG +G+V G +VAVK L + N + E+E+L L+H N+V Sbjct: 878 RDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIV 937 Query: 237 KMIGICIERRTR--CLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLH 410 K GIC+E L+ E +P+GS++ +L K ++ ++K A+ +G+ YL Sbjct: 938 KYKGICMEDGGNGIKLIMEFLPSGSLKEYL---PKNKNKINLKQQLKYAIQICKGMDYL- 993 Query: 411 EDANPHVIHRD 443 + +HRD Sbjct: 994 --GSRQYVHRD 1002
>FGFR1_CHICK (P21804) Basic fibroblast growth factor receptor 1 precursor (EC| 2.7.10.1) Length = 819 Score = 50.8 bits (120), Expect = 2e-06 Identities = 42/155 (27%), Positives = 72/155 (46%), Gaps = 22/155 (14%) Frame = +3 Query: 45 EKATDKFSFNRIIGEGGYGRVYR----GIVQDG----VEVAVKLLTGKHQNRD-REFIAE 197 E D+ + +GEG +G+V G+ +D +VAVK+L +D + I+E Sbjct: 470 ELPRDRLILGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISE 529 Query: 198 VEMLSRL-HHRNLVKMIGICIERRTRCLVFELVPNGSVESHLH-----GSDKIYGP---- 347 +EM+ + H+N++ ++G C + ++ E G++ +L G + Y P Sbjct: 530 MEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGMEYCYNPTRIP 589 Query: 348 ---LDFDTRMKIALGAARGLAYLHEDANPHVIHRD 443 L F + A ARG+ YL A+ IHRD Sbjct: 590 EEQLSFKDLVSCAYQVARGMEYL---ASKKCIHRD 621
>FGFR2_XENLA (Q03364) Fibroblast growth factor receptor 2 precursor (EC| 2.7.10.1) (FGFR-2) Length = 813 Score = 50.8 bits (120), Expect = 2e-06 Identities = 38/155 (24%), Positives = 69/155 (44%), Gaps = 22/155 (14%) Frame = +3 Query: 45 EKATDKFSFNRIIGEGGYGRVYRGIV--------QDGVEVAVKLLTGKHQNRD-REFIAE 197 E + DK + + +GEG +G+V ++ V VAVK+L +D + ++E Sbjct: 465 EFSRDKLTLGKPLGEGCFGQVVMAEALGIDKERPKESVTVAVKMLKDNATEKDLADLVSE 524 Query: 198 VEMLSRL-HHRNLVKMIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTR--- 365 +EM+ + H+N++ ++G C + T ++ E G++ +L + FD Sbjct: 525 MEMMKMIGKHKNIINLLGACTQGGTLYVIVEYAAKGNLRQYLRARRPLEMEYSFDVTRVP 584 Query: 366 ---------MKIALGAARGLAYLHEDANPHVIHRD 443 + ARG+ YL A+ IHRD Sbjct: 585 DEQMTFKDLVSCTYQIARGMEYL---ASQKCIHRD 616
>CDC2H_PLACH (Q4Y4B1) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) Length = 288 Score = 50.8 bits (120), Expect = 2e-06 Identities = 38/125 (30%), Positives = 57/125 (45%), Gaps = 2/125 (1%) Frame = +3 Query: 81 IGEGGYGRVYRGIVQDGVEVAVKLLTGKHQNRD--REFIAEVEMLSRLHHRNLVKMIGIC 254 IGEG YG VY+ DG A+K + + ++ I E+ +L L H N+VK+ + Sbjct: 10 IGEGTYGVVYKAQNSDGESFALKKIRLEKEDEGIPSTAIREISILKELRHSNIVKLYDVI 69 Query: 255 IERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVI 434 ++ LVFE + + D G L+ T L G+AY HE V+ Sbjct: 70 HAKKRLILVFEHLDQDLKKL----IDVCDGGLESVTAKSFLLQLLNGIAYCHEH---RVL 122 Query: 435 HRDFR 449 HRD + Sbjct: 123 HRDLK 127
>CDC2H_PLABA (Q4Z6R1) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) Length = 288 Score = 50.8 bits (120), Expect = 2e-06 Identities = 38/125 (30%), Positives = 57/125 (45%), Gaps = 2/125 (1%) Frame = +3 Query: 81 IGEGGYGRVYRGIVQDGVEVAVKLLTGKHQNRD--REFIAEVEMLSRLHHRNLVKMIGIC 254 IGEG YG VY+ DG A+K + + ++ I E+ +L L H N+VK+ + Sbjct: 10 IGEGTYGVVYKAQNSDGESFALKKIRLEKEDEGIPSTAIREISILKELRHSNIVKLYDVI 69 Query: 255 IERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVI 434 ++ LVFE + + D G L+ T L G+AY HE V+ Sbjct: 70 HAKKRLILVFEHLDQDLKKL----IDVCDGGLESVTAKSFLLQLLNGIAYCHEH---RVL 122 Query: 435 HRDFR 449 HRD + Sbjct: 123 HRDLK 127
>MUSK_CHICK (Q8AXY6) Muscle, skeletal receptor tyrosine protein kinase precursor| (EC 2.7.10.1) (Muscle-specific tyrosine protein kinase receptor) (Muscle-specific kinase receptor) (MuSK) Length = 947 Score = 50.8 bits (120), Expect = 2e-06 Identities = 43/169 (25%), Positives = 77/169 (45%), Gaps = 25/169 (14%) Frame = +3 Query: 12 PTVKTFSISELEKATDKFSFNRIIGEGGYGRVYR----GIV--QDGVEVAVKLLTGKHQ- 170 P + + LE + + R IGEG +GRV++ G++ + VAVK+L + Sbjct: 638 PLLLNPKLLSLEYPRNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASA 697 Query: 171 NRDREFIAEVEMLSRLHHRNLVKMIGICIERRTRCLVFELVPNGSVESHLHGSDK----- 335 + +F E +++ + N+VK++G+C + CL+FE + G + +L Sbjct: 698 DMQADFQREAALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEYLRDRSPRNLCS 757 Query: 336 -IYGPLD------------FDTRMKIALGAARGLAYLHEDANPHVIHRD 443 + G L+ +++ IA A G+AYL E +HRD Sbjct: 758 LVQGGLEARACLLNPLALCCTSQLCIAKQVAAGMAYLSE---RKFVHRD 803
>CD2L7_CAEEL (P46551) Putative cell division cycle 2-related protein kinase 7| (EC 2.7.11.22) Length = 730 Score = 50.8 bits (120), Expect = 2e-06 Identities = 46/141 (32%), Positives = 72/141 (51%), Gaps = 18/141 (12%) Frame = +3 Query: 81 IGEGGYGRVYRGIVQ-DGVEVAVKLLTGKHQNRDREF----IAEVEMLSRLHHRNLVKMI 245 IGEG YG+VY+ + G +VA+K + + +N F I E+++L +LHH+N+V+++ Sbjct: 317 IGEGTYGQVYKAVNNLTGEQVALKRV--RLENEKEGFPITAIREIKILRQLHHKNIVRLM 374 Query: 246 GICIE-------RRTRC---LVFELVPN---GSVESHLHGSDKIYGPLDFDTRMKIALGA 386 I I+ +RTR LVFE V + G +ES K + D + Sbjct: 375 DIVIDDISMDELKRTRANFYLVFEYVDHDLIGLLES------KELVDFNKDQICSLFKQL 428 Query: 387 ARGLAYLHEDANPHVIHRDFR 449 GLAY+H N +HRD + Sbjct: 429 LEGLAYIH---NTGFLHRDIK 446
>TAO1B_XENLA (Q7ZYJ0) Serine/threonine-protein kinase TAO1-B (EC 2.7.11.1)| (Thousand and one amino acid protein 1-B) Length = 1001 Score = 50.8 bits (120), Expect = 2e-06 Identities = 50/151 (33%), Positives = 69/151 (45%), Gaps = 4/151 (2%) Frame = +3 Query: 9 PPTVKTFSISELEKATDKFSFNRIIGEGGYGRVYRGI-VQDGVEVAVKLLT--GKHQNRD 179 P + F + EK FS R IG G +G VY + VA+K ++ GK N Sbjct: 13 PDVAELFFRDDPEKL---FSDLREIGHGSFGAVYFAHDARTSEVVAIKKMSYSGKQSNEK 69 Query: 180 -REFIAEVEMLSRLHHRNLVKMIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDF 356 ++ I EV+ L R+ H N ++ G + T LV E GS L K PL Sbjct: 70 WQDIIKEVKFLQRIQHPNSIEYKGCYLREHTAWLVMEYCL-GSASDLLEVHKK---PLQE 125 Query: 357 DTRMKIALGAARGLAYLHEDANPHVIHRDFR 449 I GA +GLAYLH + ++IHRD + Sbjct: 126 IEIAAITHGALQGLAYLH---SHNLIHRDIK 153
>FRK_HUMAN (P42685) Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear| tyrosine protein kinase RAK) Length = 505 Score = 50.8 bits (120), Expect = 2e-06 Identities = 31/121 (25%), Positives = 61/121 (50%) Frame = +3 Query: 81 IGEGGYGRVYRGIVQDGVEVAVKLLTGKHQNRDREFIAEVEMLSRLHHRNLVKMIGICIE 260 +G G +G V+ G+ + VAVK L + + +F+ E +++ L H L+++ +C Sbjct: 240 LGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPN-DFLREAQIMKNLRHPKLIQLYAVCTL 298 Query: 261 RRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHR 440 ++ EL+ +GS++ +L + ++ +A A G+AYL + + IHR Sbjct: 299 EDPIYIITELMRHGSLQEYLQNDTG--SKIHLTQQVDMAAQVASGMAYLE---SRNYIHR 353 Query: 441 D 443 D Sbjct: 354 D 354
>XMRK_XIPMA (P13388) Melanoma receptor tyrosine-protein kinase precursor (EC| 2.7.10.1) Length = 1167 Score = 50.8 bits (120), Expect = 2e-06 Identities = 37/135 (27%), Positives = 76/135 (56%), Gaps = 7/135 (5%) Frame = +3 Query: 60 KFSFNRIIGEGGYGRVYRGIVQ-DG----VEVAVKLLTGKHQNR-DREFIAEVEMLSRLH 221 +F +R++G G +G VY+G+ DG + VA+K+L + ++E + E +++ + Sbjct: 709 EFKKDRVLGSGAFGTVYKGLWNPDGENIRIPVAIKVLREATSPKVNQEVLDEAYVMASVD 768 Query: 222 HRNLVKMIGICIERRTRCLVFELVPNGSVESHL-HGSDKIYGPLDFDTRMKIALGAARGL 398 H ++ +++GIC+ + LV +L+P G + ++ ++I G + ++I A+G+ Sbjct: 769 HPHVCRLLGICLTSAVQ-LVTQLMPYGCLLDYVRQHQERICGQWLLNWCVQI----AKGM 823 Query: 399 AYLHEDANPHVIHRD 443 YL E H++HRD Sbjct: 824 NYLEE---RHLVHRD 835
>VAB1_CAEEL (O61460) Ephrin receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein| kinase Eph receptor) (Variable abnormal protein 1) Length = 1122 Score = 50.8 bits (120), Expect = 2e-06 Identities = 33/133 (24%), Positives = 62/133 (46%), Gaps = 1/133 (0%) Frame = +3 Query: 33 ISELEKATDKFSF-NRIIGEGGYGRVYRGIVQDGVEVAVKLLTGKHQNRDREFIAEVEML 209 +S+ A K+S N +G GG G Y + V + L +G EF+ E ++ Sbjct: 711 LSKNSPAAAKWSVSNTTMGRGGGGGGYESEPYETVAIKT-LKSGSSAKAKAEFLTEATIM 769 Query: 210 SRLHHRNLVKMIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAA 389 + H N++++IG+ +V E + NGS++ L +D+ + ++ ++ G A Sbjct: 770 GQFSHPNVIRLIGVVTSAEPVMIVAEYMANGSLDQFLRNTDQRGEKVHWEKITEMLYGIA 829 Query: 390 RGLAYLHEDANPH 428 G+ YL + H Sbjct: 830 SGMKYLTDMGYVH 842
>DDR1_MOUSE (Q03146) Epithelial discoidin domain-containing receptor 1 precursor| (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (Protei Length = 911 Score = 50.4 bits (119), Expect = 2e-06 Identities = 42/161 (26%), Positives = 74/161 (45%), Gaps = 33/161 (20%) Frame = +3 Query: 60 KFSFNRIIGEGGYGRVYRGIVQDGVE-----------------VAVKLLT-GKHQNRDRE 185 + F +GEG +G V+ V+D + VAVK+L +N + Sbjct: 607 RLRFKEKLGEGQFGEVHLCEVEDPQDLVSSDFPISVHKGHPLLVAVKILRPDATKNARND 666 Query: 186 FIAEVEMLSRLHHRNLVKMIGICIERRTRCLVFELVPNGSVESHLHG---SDKIYGPLDF 356 F+ EV+++SRL N+++++G+C++ C++ + + NG + L +K L Sbjct: 667 FLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSARQLENKATQGLSG 726 Query: 357 DTR----------MKIALGA--ARGLAYLHEDANPHVIHRD 443 DT M + +GA A G+ YL A + +HRD Sbjct: 727 DTESDQGPTISYPMLLHVGAQIASGMRYL---ATLNFVHRD 764
>EPHB2_CHICK (P28693) Ephrin type-B receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor CEK5) Length = 1004 Score = 50.4 bits (119), Expect = 2e-06 Identities = 34/128 (26%), Positives = 67/128 (52%), Gaps = 5/128 (3%) Frame = +3 Query: 75 RIIGEGGYGRVYRGIVQ----DGVEVAVKLL-TGKHQNRDREFIAEVEMLSRLHHRNLVK 239 ++IG G +G V G ++ + VA+K L +G + + R+F++E ++ + H N++ Sbjct: 643 QVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNVIH 702 Query: 240 MIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDA 419 + G+ + ++ E + NGS++S L +D G + + G A G+ YL A Sbjct: 703 LEGVVTKSSPVMIITEFMENGSLDSFLRQND---GQFTVIQLVGMLRGIAAGMKYL---A 756 Query: 420 NPHVIHRD 443 + + +HRD Sbjct: 757 DMNYVHRD 764
>TESK2_RAT (Q924U5) Dual specificity testis-specific protein kinase 2 (EC| 2.7.12.1) (Testicular protein kinase 2) Length = 570 Score = 50.4 bits (119), Expect = 2e-06 Identities = 37/138 (26%), Positives = 68/138 (49%), Gaps = 1/138 (0%) Frame = +3 Query: 33 ISELEKATDKFSFNRI-IGEGGYGRVYRGIVQDGVEVAVKLLTGKHQNRDREFIAEVEML 209 IS + T F R IG G + V++ + +V + NR + E++++ Sbjct: 47 ISAFSRLTSLDDFTREKIGSGFFSEVFKVRHRASGQVMALKMNTLSSNR-ANLLKEMQLM 105 Query: 210 SRLHHRNLVKMIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAA 389 +RL H N+++ +G+C+ + + E + +G++E L +Y L + R+K+A A Sbjct: 106 NRLSHPNILRFMGVCVHQGQLHALTEYINSGNLEQLL--DSNLY--LPWTVRVKLAYDIA 161 Query: 390 RGLAYLHEDANPHVIHRD 443 GL+YLH + HRD Sbjct: 162 VGLSYLHFKG---IFHRD 176
>PTK7_HUMAN (Q13308) Tyrosine-protein kinase-like 7 precursor (Colon carcinoma| kinase 4) (CCK-4) Length = 1070 Score = 50.4 bits (119), Expect = 2e-06 Identities = 41/148 (27%), Positives = 69/148 (46%), Gaps = 18/148 (12%) Frame = +3 Query: 54 TDKFSFNR-------IIGEGGYGRVYRGIVQ---DGVE---VAVKLLTGKHQNRDREFIA 194 +DK F R +G+ +G V+ Q +GV V VK L K + + +F Sbjct: 786 SDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQLDFRR 845 Query: 195 EVEMLSRLHHRNLVKMIGICIERRTRCLVFELVPNGSVESHLH---GSDKIYGPLDFDTR 365 E+EM +L+H N+V+++G+C E +V E V ++ L D+ T+ Sbjct: 846 ELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLEDLKQFLRISKSKDEKLKSQPLSTK 905 Query: 366 MKIAL--GAARGLAYLHEDANPHVIHRD 443 K+AL A G+ +L +N +H+D Sbjct: 906 QKVALCTQVALGMEHL---SNNRFVHKD 930
>BMX_HUMAN (P51813) Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2)| (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38) Length = 675 Score = 50.4 bits (119), Expect = 2e-06 Identities = 35/133 (26%), Positives = 62/133 (46%) Frame = +3 Query: 45 EKATDKFSFNRIIGEGGYGRVYRGIVQDGVEVAVKLLTGKHQNRDREFIAEVEMLSRLHH 224 E ++ + + +G G +G V G + +VAVK++ + D EF E + + +L H Sbjct: 411 ELKREEITLLKELGSGQFGVVQLGKWKGQYDVAVKMIKEGSMSED-EFFQEAQTMMKLSH 469 Query: 225 RNLVKMIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAY 404 LVK G+C + +V E + NG + ++L K P +++ G+A+ Sbjct: 470 PKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQL---LEMCYDVCEGMAF 526 Query: 405 LHEDANPHVIHRD 443 L + IHRD Sbjct: 527 LE---SHQFIHRD 536
>EPHB2_COTJA (Q90344) Ephrin type-B receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor QEK5) Length = 987 Score = 50.4 bits (119), Expect = 2e-06 Identities = 34/128 (26%), Positives = 67/128 (52%), Gaps = 5/128 (3%) Frame = +3 Query: 75 RIIGEGGYGRVYRGIVQ----DGVEVAVKLL-TGKHQNRDREFIAEVEMLSRLHHRNLVK 239 ++IG G +G V G ++ + VA+K L +G + + R+F++E ++ + H N++ Sbjct: 626 QVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNVIH 685 Query: 240 MIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDA 419 + G+ + ++ E + NGS++S L +D G + + G A G+ YL A Sbjct: 686 LEGVVTKSSPVMIITEFMENGSLDSFLRQND---GQFTVIQLVGMLRGIAAGMKYL---A 739 Query: 420 NPHVIHRD 443 + + +HRD Sbjct: 740 DMNYVHRD 747
>M4K4_HUMAN (O95819) Mitogen-activated protein kinase kinase kinase kinase 4| (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase) Length = 1239 Score = 50.4 bits (119), Expect = 2e-06 Identities = 44/147 (29%), Positives = 67/147 (45%), Gaps = 8/147 (5%) Frame = +3 Query: 33 ISELEKATDKFSFNRIIGEGGYGRVYRG-IVQDGVEVAVKLLTGKHQNRDREFIAEVEML 209 +S L F ++G G YG+VY+G V+ G A+K++ ++ + E E+ ML Sbjct: 15 LSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVM-DVTEDEEEEIKLEINML 73 Query: 210 SRL-HHRNLVKMIGICIERR------TRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRM 368 + HHRN+ G I++ LV E GS+ + + L D Sbjct: 74 KKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKG--NTLKEDWIA 131 Query: 369 KIALGAARGLAYLHEDANPHVIHRDFR 449 I+ RGLA+LH HVIHRD + Sbjct: 132 YISREILRGLAHLHIH---HVIHRDIK 155
>EPHB2_MOUSE (P54763) Ephrin type-B receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EPH-3) (Neural kinase) (Nuk receptor tyrosine kinase) (SEK-3) Length = 994 Score = 50.4 bits (119), Expect = 2e-06 Identities = 34/128 (26%), Positives = 67/128 (52%), Gaps = 5/128 (3%) Frame = +3 Query: 75 RIIGEGGYGRVYRGIVQ----DGVEVAVKLL-TGKHQNRDREFIAEVEMLSRLHHRNLVK 239 ++IG G +G V G ++ + VA+K L +G + + R+F++E ++ + H N++ Sbjct: 633 QVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNVIH 692 Query: 240 MIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDA 419 + G+ + ++ E + NGS++S L +D G + + G A G+ YL A Sbjct: 693 LEGVVTKSTPVMIITEFMENGSLDSFLRQND---GQFTVIQLVGMLRGIAAGMKYL---A 746 Query: 420 NPHVIHRD 443 + + +HRD Sbjct: 747 DMNYVHRD 754
>EPHB2_HUMAN (P29323) Ephrin type-B receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EPH-3) (DRT) (Receptor protein-tyrosine kinase HEK5) (ERK) (NY-REN-47 antigen) Length = 1055 Score = 50.4 bits (119), Expect = 2e-06 Identities = 34/128 (26%), Positives = 67/128 (52%), Gaps = 5/128 (3%) Frame = +3 Query: 75 RIIGEGGYGRVYRGIVQ----DGVEVAVKLL-TGKHQNRDREFIAEVEMLSRLHHRNLVK 239 ++IG G +G V G ++ + VA+K L +G + + R+F++E ++ + H N++ Sbjct: 625 QVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNVIH 684 Query: 240 MIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDA 419 + G+ + ++ E + NGS++S L +D G + + G A G+ YL A Sbjct: 685 LEGVVTKSTPVMIITEFMENGSLDSFLRQND---GQFTVIQLVGMLRGIAAGMKYL---A 738 Query: 420 NPHVIHRD 443 + + +HRD Sbjct: 739 DMNYVHRD 746
>CDKL2_RAT (Q5XIT0) Cyclin-dependent kinase-like 2 (EC 2.7.11.22)| Length = 507 Score = 50.4 bits (119), Expect = 2e-06 Identities = 37/135 (27%), Positives = 69/135 (51%), Gaps = 4/135 (2%) Frame = +3 Query: 57 DKFSFNRIIGEGGYGRVYRGIVQD-GVEVAVKLLTGKHQNRDREFIA--EVEMLSRLHHR 227 +K+ ++GEG YG V + +D G VA+K ++ + IA E+++L +L H Sbjct: 2 EKYENLGLVGEGSYGMVMKCRNKDSGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRHE 61 Query: 228 NLVKMIGICIERRTRCLVFELVPNGSVESHLHGSDKIY-GPLDFDTRMKIALGAARGLAY 404 NLV ++ +C +++ LVFE V + ++ K++ LD+ K G+ + Sbjct: 62 NLVNLLEVCKKKKRWYLVFEFVDHTILDDL-----KLFPNGLDYQVVQKYLFQIINGIGF 116 Query: 405 LHEDANPHVIHRDFR 449 H + ++IHRD + Sbjct: 117 CH---SHNIIHRDIK 128
>CDKL2_MOUSE (Q9QUK0) Cyclin-dependent kinase-like 2 (EC 2.7.11.22)| (Serine/threonine-protein kinase KKIAMRE) Length = 568 Score = 50.4 bits (119), Expect = 2e-06 Identities = 37/135 (27%), Positives = 69/135 (51%), Gaps = 4/135 (2%) Frame = +3 Query: 57 DKFSFNRIIGEGGYGRVYRGIVQD-GVEVAVKLLTGKHQNRDREFIA--EVEMLSRLHHR 227 +K+ ++GEG YG V + +D G VA+K ++ + IA E+++L +L H Sbjct: 2 EKYENLGLVGEGSYGMVMKCRNKDSGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRHE 61 Query: 228 NLVKMIGICIERRTRCLVFELVPNGSVESHLHGSDKIY-GPLDFDTRMKIALGAARGLAY 404 NLV ++ +C +++ LVFE V + ++ K++ LD+ K G+ + Sbjct: 62 NLVNLLEVCKKKKRWYLVFEFVDHTILDDL-----KLFPNGLDYQVVQKYLFQIINGIGF 116 Query: 405 LHEDANPHVIHRDFR 449 H + ++IHRD + Sbjct: 117 CH---SHNIIHRDIK 128
>IRAK3_MOUSE (Q8K4B2) Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1)| (IRAK-3) (IL-1 receptor-associated kinase M) (IRAK-M) Length = 609 Score = 50.4 bits (119), Expect = 2e-06 Identities = 34/131 (25%), Positives = 67/131 (51%), Gaps = 4/131 (3%) Frame = +3 Query: 30 SISELEKATDKFSFNRIIGEGGYGRVYRGIVQDGVEVAVKLLTGKHQNRDRE----FIAE 197 S + + T F + +IGEG VYR +++ AVKL + + + ++ F++E Sbjct: 167 SFQSILEGTKHFHKDFLIGEGEIFEVYRVDIRNQA-YAVKLFKQEKKMQLKKHWKRFLSE 225 Query: 198 VEMLSRLHHRNLVKMIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIA 377 +E+L H +++++ E CLV+ + NG++ L ++ PL + R+ + Sbjct: 226 LEVLLLFRHPHILELAAYFTETEKLCLVYPYMSNGTLFDRLQCTNGT-TPLSWHVRISVL 284 Query: 378 LGAARGLAYLH 410 +G A+ + YLH Sbjct: 285 IGIAKAIQYLH 295
>FGFR4_MOUSE (Q03142) Fibroblast growth factor receptor 4 precursor (EC| 2.7.10.1) (FGFR-4) (Protein-tyrosine kinase receptor MPK-11) Length = 799 Score = 50.4 bits (119), Expect = 2e-06 Identities = 37/151 (24%), Positives = 66/151 (43%), Gaps = 22/151 (14%) Frame = +3 Query: 57 DKFSFNRIIGEGGYGRVYRGIV--------QDGVEVAVKLLTGKHQNRD-REFIAEVEML 209 D+ + +GEG +G+V R VAVK+L ++D + ++E+E++ Sbjct: 462 DRLVLGKPLGEGCFGQVVRAEAFGMDPSRPDQTSTVAVKMLKDNASDKDLADLVSEMEVM 521 Query: 210 SRL-HHRNLVKMIGICIERRTRCLVFELVPNGSVESHLH------------GSDKIYGPL 350 + H+N++ ++G+C + ++ E G++ L G GPL Sbjct: 522 KLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPL 581 Query: 351 DFDTRMKIALGAARGLAYLHEDANPHVIHRD 443 F + A ARG+ YL + IHRD Sbjct: 582 SFPALVSCAYQVARGMQYLE---SRKCIHRD 609
>LCK_MOUSE (P06240) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) Length = 508 Score = 50.4 bits (119), Expect = 2e-06 Identities = 36/125 (28%), Positives = 62/125 (49%) Frame = +3 Query: 81 IGEGGYGRVYRGIVQDGVEVAVKLLTGKHQNRDREFIAEVEMLSRLHHRNLVKMIGICIE 260 +G G +G V+ G +VAVK L + D F+AE ++ +L H LV++ + + Sbjct: 250 LGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDA-FLAEANLMKQLQHPRLVRLYAV-VT 307 Query: 261 RRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHR 440 + ++ E + NGS+ L I L+ + + +A A G+A++ E + IHR Sbjct: 308 QEPIYIITEYMENGSLVDFLKTPSGI--KLNVNKLLDMAAQIAEGMAFIEEQ---NYIHR 362 Query: 441 DFRLA 455 D R A Sbjct: 363 DLRAA 367
>LCK_HUMAN (P06239) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell-specific protein-tyrosine kinase) Length = 508 Score = 50.4 bits (119), Expect = 2e-06 Identities = 36/125 (28%), Positives = 62/125 (49%) Frame = +3 Query: 81 IGEGGYGRVYRGIVQDGVEVAVKLLTGKHQNRDREFIAEVEMLSRLHHRNLVKMIGICIE 260 +G G +G V+ G +VAVK L + D F+AE ++ +L H+ LV++ + + Sbjct: 250 LGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDA-FLAEANLMKQLQHQRLVRLYAV-VT 307 Query: 261 RRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHR 440 + ++ E + NGS+ L I L + + +A A G+A++ E + IHR Sbjct: 308 QEPIYIITEYMENGSLVDFLKTPSGI--KLTINKLLDMAAQIAEGMAFIEE---RNYIHR 362 Query: 441 DFRLA 455 D R A Sbjct: 363 DLRAA 367
>MUSK_HUMAN (O15146) Muscle, skeletal receptor tyrosine protein kinase precursor| (EC 2.7.10.1) (Muscle-specific tyrosine protein kinase receptor) (Muscle-specific kinase receptor) (MuSK) Length = 869 Score = 50.4 bits (119), Expect = 2e-06 Identities = 44/171 (25%), Positives = 74/171 (43%), Gaps = 27/171 (15%) Frame = +3 Query: 12 PTVKTFSISELEKATDKFSFNRIIGEGGYGRVYR----GIV--QDGVEVAVKLLTGKHQ- 170 P + + LE + + R IGEG +GRV++ G++ + VAVK+L + Sbjct: 558 PLLLNPKLLSLEYPRNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASA 617 Query: 171 NRDREFIAEVEMLSRLHHRNLVKMIGICIERRTRCLVFELVPNGSVESHLHG-------- 326 + +F E +++ + N+VK++G+C + CL+FE + G + L Sbjct: 618 DMQADFQREAALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCS 677 Query: 327 ------------SDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRD 443 S PL ++ IA A G+AYL E +HRD Sbjct: 678 LSHSDLSMRAQVSSPGPPPLSCAEQLCIARQVAAGMAYLSE---RKFVHRD 725
>MUSK_RAT (Q62838) Muscle, skeletal receptor tyrosine protein kinase precursor| (EC 2.7.10.1) (Muscle-specific kinase receptor) (MuSK) Length = 868 Score = 50.4 bits (119), Expect = 2e-06 Identities = 44/171 (25%), Positives = 74/171 (43%), Gaps = 27/171 (15%) Frame = +3 Query: 12 PTVKTFSISELEKATDKFSFNRIIGEGGYGRVYR----GIV--QDGVEVAVKLLTGKHQ- 170 P + + LE + + R IGEG +GRV++ G++ + VAVK+L + Sbjct: 557 PLLLNPKLLSLEYPRNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASA 616 Query: 171 NRDREFIAEVEMLSRLHHRNLVKMIGICIERRTRCLVFELVPNGSVESHLHG-------- 326 + +F E +++ + N+VK++G+C + CL+FE + G + L Sbjct: 617 DMQADFQREAALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCS 676 Query: 327 ------------SDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRD 443 S PL ++ IA A G+AYL E +HRD Sbjct: 677 LSHSDLSTRARVSSPGPPPLSCAEQLCIARQVAAGMAYLSE---RKFVHRD 724
>MUSK_MOUSE (Q61006) Muscle, skeletal receptor tyrosine protein kinase precursor| (EC 2.7.10.1) (Muscle-specific kinase receptor) (MuSK) Length = 868 Score = 50.4 bits (119), Expect = 2e-06 Identities = 44/171 (25%), Positives = 74/171 (43%), Gaps = 27/171 (15%) Frame = +3 Query: 12 PTVKTFSISELEKATDKFSFNRIIGEGGYGRVYR----GIV--QDGVEVAVKLLTGKHQ- 170 P + + LE + + R IGEG +GRV++ G++ + VAVK+L + Sbjct: 557 PLLLNPKLLSLEYPRNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASA 616 Query: 171 NRDREFIAEVEMLSRLHHRNLVKMIGICIERRTRCLVFELVPNGSVESHLHG-------- 326 + +F E +++ + N+VK++G+C + CL+FE + G + L Sbjct: 617 DMQADFQREAALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCS 676 Query: 327 ------------SDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVIHRD 443 S PL ++ IA A G+AYL E +HRD Sbjct: 677 LSHSDLSTRARVSSPGPPPLSCAEQLCIARQVAAGMAYLSE---RKFVHRD 724
>CDC2H_PLAYO (Q7RM49) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) Length = 289 Score = 50.4 bits (119), Expect = 2e-06 Identities = 38/126 (30%), Positives = 57/126 (45%), Gaps = 3/126 (2%) Frame = +3 Query: 81 IGEGGYGRVYRGIVQDGVEVAVKLLTGKHQNR---DREFIAEVEMLSRLHHRNLVKMIGI 251 IGEG YG VY+ DG A+K + + ++ I E+ +L L H N+VK+ + Sbjct: 10 IGEGTYGVVYKAQNSDGESFALKKIRLEKEDEGIPSTVSIREISILKELRHSNIVKLYDV 69 Query: 252 CIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHV 431 ++ LVFE + + D G L+ T L G+AY HE V Sbjct: 70 IHAKKRLILVFEHLDQDLKKL----IDVCDGGLESVTAKSFLLQLLNGIAYCHEH---RV 122 Query: 432 IHRDFR 449 +HRD + Sbjct: 123 LHRDLK 128
>EPHA7_RAT (P54759) Ephrin type-A receptor 7 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) Length = 998 Score = 50.4 bits (119), Expect = 2e-06 Identities = 36/128 (28%), Positives = 63/128 (49%), Gaps = 5/128 (3%) Frame = +3 Query: 75 RIIGEGGYGRVYRGIVQ----DGVEVAVKLL-TGKHQNRDREFIAEVEMLSRLHHRNLVK 239 R+IG G +G V G ++ V VA+K L G + + R+F+ E ++ + H N+V Sbjct: 637 RVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTEKQRRDFLCEASIMGQFDHPNVVH 696 Query: 240 MIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDA 419 + G+ + +V E + NG++++ L D G + + G A G+ YL A Sbjct: 697 LEGVVTRGKPVMIVIEFMENGALDAFLRKHD---GQFTVIQLVGMLRGIAAGMRYL---A 750 Query: 420 NPHVIHRD 443 + +HRD Sbjct: 751 DMGYVHRD 758
>EPHA7_HUMAN (Q15375) Ephrin type-A receptor 7 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Receptor protein-tyrosine kinase HEK11) Length = 998 Score = 50.4 bits (119), Expect = 2e-06 Identities = 36/128 (28%), Positives = 63/128 (49%), Gaps = 5/128 (3%) Frame = +3 Query: 75 RIIGEGGYGRVYRGIVQ----DGVEVAVKLL-TGKHQNRDREFIAEVEMLSRLHHRNLVK 239 R+IG G +G V G ++ V VA+K L G + + R+F+ E ++ + H N+V Sbjct: 637 RVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTEKQRRDFLCEASIMGQFDHPNVVH 696 Query: 240 MIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDA 419 + G+ + +V E + NG++++ L D G + + G A G+ YL A Sbjct: 697 LEGVVTRGKPVMIVIEFMENGALDAFLRKHD---GQFTVIQLVGMLRGIAAGMRYL---A 750 Query: 420 NPHVIHRD 443 + +HRD Sbjct: 751 DMGYVHRD 758
>TESK2_MOUSE (Q8VCT9) Dual specificity testis-specific protein kinase 2 (EC| 2.7.12.1) (Testicular protein kinase 2) Length = 570 Score = 50.1 bits (118), Expect = 3e-06 Identities = 37/138 (26%), Positives = 68/138 (49%), Gaps = 1/138 (0%) Frame = +3 Query: 33 ISELEKATDKFSFNRI-IGEGGYGRVYRGIVQDGVEVAVKLLTGKHQNRDREFIAEVEML 209 IS + T F R IG G + V++ + +V + NR + E++++ Sbjct: 47 ISAFSRLTSLDDFTREKIGSGFFSEVFKVRHRASGQVMALKMNTLSSNR-ANLLKEMQLM 105 Query: 210 SRLHHRNLVKMIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAA 389 +RL H N+++ +G+C+ + + E + +G++E L +Y L + R+K+A A Sbjct: 106 NRLSHPNILRFMGVCVHQGQLHALTEYINSGNLEQLL--DSDLY--LPWTVRVKLAYDIA 161 Query: 390 RGLAYLHEDANPHVIHRD 443 GL+YLH + HRD Sbjct: 162 VGLSYLHFKG---IFHRD 176
>M3K1_HUMAN (Q13233) Mitogen-activated protein kinase kinase kinase 1 (EC| 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1) (Fragment) Length = 1495 Score = 50.1 bits (118), Expect = 3e-06 Identities = 40/130 (30%), Positives = 65/130 (50%), Gaps = 7/130 (5%) Frame = +3 Query: 81 IGEGGYGRVYRGI-VQDGVEVAVKLLTG-KHQNRDREFIAE-----VEMLSRLHHRNLVK 239 IG G + Y+ V G +AVK +T ++ + ++E + E + M+S L+H N+++ Sbjct: 1232 IGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMSHLNHPNIIR 1291 Query: 240 MIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDA 419 M+G E+ L E + GSV +HL YG + RGL+YLHE+ Sbjct: 1292 MLGATCEKSNYNLFIEWMAGGSV-AHLLSK---YGAFKESVVINYTEQLLRGLSYLHEN- 1346 Query: 420 NPHVIHRDFR 449 +IHRD + Sbjct: 1347 --QIIHRDVK 1354
>EPHB3_BRARE (O13147) Ephrin type-B receptor 3 (EC 2.7.10.1) (Tyrosine-protein| kinase receptor ZEK3) (EPH-like kinase 3) (Fragment) Length = 500 Score = 50.1 bits (118), Expect = 3e-06 Identities = 34/127 (26%), Positives = 65/127 (51%), Gaps = 5/127 (3%) Frame = +3 Query: 78 IIGEGGYGRVYRGIVQDG----VEVAVKLL-TGKHQNRDREFIAEVEMLSRLHHRNLVKM 242 +IG G +G V RG ++ VA+K L G +++ R+F++E ++ + H N++ + Sbjct: 192 VIGAGEFGEVCRGRLKQAGRKETTVAIKTLKAGYTEHQRRDFLSEASIMGQFDHPNVIHL 251 Query: 243 IGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDAN 422 G+ +V E + NG+++S L +D G + + G A G+ YL ++ Sbjct: 252 EGVLTRSCPVLIVTEFMENGALDSFLRLND---GRFTVTQLVGMLRGIAAGMKYL---SD 305 Query: 423 PHVIHRD 443 + +HRD Sbjct: 306 MNYVHRD 312
>EPHA7_CHICK (O42422) Ephrin type-A receptor 7 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor CEPHA7) (Tyrosine-protein kinase receptor CEK11) Length = 993 Score = 50.1 bits (118), Expect = 3e-06 Identities = 36/128 (28%), Positives = 63/128 (49%), Gaps = 5/128 (3%) Frame = +3 Query: 75 RIIGEGGYGRVYRGIVQ----DGVEVAVKLL-TGKHQNRDREFIAEVEMLSRLHHRNLVK 239 R+IG G +G V G ++ V VA+K L G + + R+F+ E ++ + H N+V Sbjct: 632 RVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTEKQRRDFLCEASIMGQFDHPNVVH 691 Query: 240 MIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDA 419 + G+ + +V E + NG++++ L D G + + G A G+ YL A Sbjct: 692 LEGVVTRGKPVMIVIEYMENGALDAFLRKHD---GQFTVIQLVGMLRGIAAGMRYL---A 745 Query: 420 NPHVIHRD 443 + +HRD Sbjct: 746 DMGYVHRD 753
>RIPK1_MOUSE (Q60855) Receptor-interacting serine/threonine-protein kinase 1 (EC| 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein) Length = 656 Score = 50.1 bits (118), Expect = 3e-06 Identities = 41/142 (28%), Positives = 68/142 (47%), Gaps = 2/142 (1%) Frame = +3 Query: 30 SISELEKATDKFSFNRIIGEGGYGRVYRGIVQD-GVEVAVKLLTGKHQNRDREFIAEV-E 203 S+ ++ A+ + GG+G+V + G + K+ TG ++ E + E + Sbjct: 6 SLDNIKMASSDLLEKTDLDSGGFGKVSLCYHRSHGFVILKKVYTGPNRAEYNEVLLEEGK 65 Query: 204 MLSRLHHRNLVKMIGICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALG 383 M+ RL H +VK++GI IE LV E + G++ L +I PL R I + Sbjct: 66 MMHRLRHSRVVKLLGIIIEEGNYSLVMEYMEKGNLMHVL--KTQIDVPLSLKGR--IIVE 121 Query: 384 AARGLAYLHEDANPHVIHRDFR 449 A G+ YLH+ VIH+D + Sbjct: 122 AIEGMCYLHDKG---VIHKDLK 140
>BTK_CHICK (Q8JH64) Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton's| tyrosine kinase) Length = 657 Score = 50.1 bits (118), Expect = 3e-06 Identities = 31/126 (24%), Positives = 63/126 (50%) Frame = +3 Query: 66 SFNRIIGEGGYGRVYRGIVQDGVEVAVKLLTGKHQNRDREFIAEVEMLSRLHHRNLVKMI 245 +F + +G G +G V G + VA+K++ + D EFI E +++ L H LV++ Sbjct: 401 TFLKELGTGQFGVVKYGKWRGQYNVAIKMIREGSMSED-EFIDEAKVMMNLSHEKLVQLY 459 Query: 246 GICIERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANP 425 G+C ++R ++ E + NG + + L + + + P + +++ + YL + Sbjct: 460 GVCTKQRPIFIITEYMANGCLLNFLRETQRRFQPAEL---LEMCKDVCEAMEYLE---SK 513 Query: 426 HVIHRD 443 +HRD Sbjct: 514 QFLHRD 519
>FES_FSVST (P00543) Tyrosine-protein kinase transforming protein Fes (EC| 2.7.10.2) Length = 477 Score = 50.1 bits (118), Expect = 3e-06 Identities = 37/123 (30%), Positives = 60/123 (48%), Gaps = 2/123 (1%) Frame = +3 Query: 81 IGEGGYGRVYRGIVQ-DGVEVAVKLLTGK-HQNRDREFIAEVEMLSRLHHRNLVKMIGIC 254 IG G +G V+ G ++ D VAVK + +F+ E ++L + H N+V++IG+C Sbjct: 222 IGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDIKAKFLQEAKILKQYSHPNIVRLIGVC 281 Query: 255 IERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVI 434 +++ +V ELV G + L L T +++ AA G+ YL I Sbjct: 282 TQKQPIYIVMELVQGGDFLTFLRTEG---ARLRMKTLLQMVGDAAAGMEYLESKC---CI 335 Query: 435 HRD 443 HRD Sbjct: 336 HRD 338
>FES_FELCA (P14238) Proto-oncogene tyrosine-protein kinase FES/FPS (EC| 2.7.10.2) (C-FES) Length = 820 Score = 50.1 bits (118), Expect = 3e-06 Identities = 37/123 (30%), Positives = 60/123 (48%), Gaps = 2/123 (1%) Frame = +3 Query: 81 IGEGGYGRVYRGIVQ-DGVEVAVKLLTGK-HQNRDREFIAEVEMLSRLHHRNLVKMIGIC 254 IG G +G V+ G ++ D VAVK + +F+ E ++L + H N+V++IG+C Sbjct: 565 IGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDIKAKFLQEAKILKQYSHPNIVRLIGVC 624 Query: 255 IERRTRCLVFELVPNGSVESHLHGSDKIYGPLDFDTRMKIALGAARGLAYLHEDANPHVI 434 +++ +V ELV G + L L T +++ AA G+ YL I Sbjct: 625 TQKQPIYIVMELVQGGDFLTFLRTEG---ARLRMKTLLQMVGDAAAGMEYLESKC---CI 678 Query: 435 HRD 443 HRD Sbjct: 679 HRD 681 Database: uniprot_sprot.fasta Posted date: May 25, 2006 5:36 PM Number of letters in database: 80,573,946 Number of sequences in database: 219,361 Lambda K H 0.318 0.135 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 69,102,437 Number of Sequences: 219361 Number of extensions: 1442201 Number of successful extensions: 5335 Number of sequences better than 10.0: 500 Number of HSP's better than 10.0 without gapping: 4868 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 4988 length of database: 80,573,946 effective HSP length: 103 effective length of database: 57,979,763 effective search space used: 3014947676 frameshift window, decay const: 50, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)
