ナショナルバイオリソースプロジェクト
-Barley Genetic Resources Database-
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| Clone Name | bast57c07 |
|---|---|
| Clone Library Name | barley_pub |
>RLCK7_ARATH (Q9LQQ8) Probable serine/threonine-protein kinase RLCKVII (EC| 2.7.11.1) Length = 423 Score = 128 bits (321), Expect = 9e-30 Identities = 69/158 (43%), Positives = 98/158 (62%), Gaps = 7/158 (4%) Frame = +3 Query: 6 ERFQVYEFMENGSLKDHLH--SSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDI 179 +R VYE+M GSL+DHLH SGK L W R++IA A LEYLH PP+ + D+ Sbjct: 172 QRLLVYEYMPQGSLEDHLHVLPSGKKPLDWNTRMKIAAGAARGLEYLHDRMTPPVIYRDL 231 Query: 180 KPSNVLLDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAK 359 K SN+LL ++Y KL+ G+A G+ T + ++ T GY P+Y +T +LT K Sbjct: 232 KCSNILLGEDYQPKLSDFGLAKVGPSGD----KTHVSTRVMGTYGYCAPDYAMTGQLTFK 287 Query: 360 SDVYSYGVLLLELVTGRPVVQD-----DRSLVEWSREL 458 SD+YS+GV+LLEL+TGR + + D++LV W+R L Sbjct: 288 SDIYSFGVVLLELITGRKAIDNTKTRKDQNLVGWARPL 325
>RLK5_ARATH (P47735) Receptor-like protein kinase 5 precursor (EC 2.7.11.1)| Length = 999 Score = 124 bits (311), Expect = 1e-28 Identities = 68/149 (45%), Positives = 90/149 (60%), Gaps = 6/149 (4%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSS--GKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSN 191 VYE+M NGSL D LH G ++L W R++IA+D A L YLH C PP+ H D+K SN Sbjct: 765 VYEYMPNGSLADVLHGDRKGGVVLGWPERLRIALDAAEGLSYLHHDCVPPIVHRDVKSSN 824 Query: 192 VLLDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVK-IQATPGYVDPEYVVTQELTAKSDV 368 +LLD +Y AK+A GIA G TP + I + GY+ PEYV T + KSD+ Sbjct: 825 ILLDSDYGAKVADFGIAKV---GQMSGSKTPEAMSGIAGSCGYIAPEYVYTLRVNEKSDI 881 Query: 369 YSYGVLLLELVTGRPVVQD---DRSLVEW 446 YS+GV+LLELVTG+ D+ + +W Sbjct: 882 YSFGVVLLELVTGKQPTDSELGDKDMAKW 910
>PBS1_ARATH (Q9FE20) Serine/threonine-protein kinase PBS1 (EC 2.7.11.1)| (AvrPphB susceptible protein 1) Length = 456 Score = 122 bits (305), Expect = 6e-28 Identities = 68/158 (43%), Positives = 94/158 (59%), Gaps = 7/158 (4%) Frame = +3 Query: 6 ERFQVYEFMENGSLKDHLHS--SGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDI 179 +R VYEFM GSL+DHLH K L W R++IA A LE+LH +PP+ + D Sbjct: 155 QRLLVYEFMPLGSLEDHLHDLPPDKEALDWNMRMKIAAGAAKGLEFLHDKANPPVIYRDF 214 Query: 180 KPSNVLLDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAK 359 K SN+LLD+ + KL+ G+A G+ ST ++ T GY PEY +T +LT K Sbjct: 215 KSSNILLDEGFHPKLSDFGLAKLGPTGDKSHVST----RVMGTYGYCAPEYAMTGQLTVK 270 Query: 360 SDVYSYGVLLLELVTGRPVVQD-----DRSLVEWSREL 458 SDVYS+GV+ LEL+TGR + +++LV W+R L Sbjct: 271 SDVYSFGVVFLELITGRKAIDSEMPHGEQNLVAWARPL 308
>CRI4_MAIZE (O24585) Putative receptor protein kinase CRINKLY4 precursor (EC| 2.7.11.1) Length = 901 Score = 121 bits (304), Expect = 8e-28 Identities = 67/158 (42%), Positives = 95/158 (60%), Gaps = 6/158 (3%) Frame = +3 Query: 6 ERFQVYEFMENGSLKDHLHSSG---KLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGD 176 ER VYEFM +GSL HLH K L W R+ IA+ A +EYLH Y PP+ H D Sbjct: 575 ERLLVYEFMAHGSLYQHLHGKDPNLKKRLNWARRVTIAVQAARGIEYLHGYACPPVIHRD 634 Query: 177 IKPSNVLLDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTA 356 IK SN+L+D+++ A++A G++ + TP + T GY+DPEY LT Sbjct: 635 IKSSNILIDEDHNARVADFGLSILGPADS----GTPLSELPAGTLGYLDPEYYRLHYLTT 690 Query: 357 KSDVYSYGVLLLELVTGRPVVQ---DDRSLVEWSRELI 461 KSDVYS+GV+LLE+++GR + ++ ++VEW+ LI Sbjct: 691 KSDVYSFGVVLLEILSGRKAIDMQFEEGNIVEWAVPLI 728
>SIRK_ARATH (O64483) Senescence-induced receptor-like serine/threonine-protein| kinase precursor (FLG22-induced receptor-like kinase 1) Length = 876 Score = 119 bits (299), Expect = 3e-27 Identities = 55/139 (39%), Positives = 90/139 (64%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVL 197 +YE+M N +L D+L +L W+ R++I++D A LEYLH C PP+ H D+KP+N+L Sbjct: 645 IYEYMANENLGDYLAGKRSFILSWEERLKISLDAAQGLEYLHNGCKPPIVHRDVKPTNIL 704 Query: 198 LDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVYSY 377 L++ AK+A G++ ++ GS + + + GY+DPEY T+++ KSDVYS Sbjct: 705 LNEKLQAKMADFGLSR----SFSVEGSGQISTVVAGSIGYLDPEYYSTRQMNEKSDVYSL 760 Query: 378 GVLLLELVTGRPVVQDDRS 434 GV+LLE++TG+P + ++ Sbjct: 761 GVVLLEVITGQPAIASSKT 779
>BRL3_ARATH (Q9LJF3) Serine/threonine-protein kinase BRI1-like 3 precursor (EC| 2.7.11.1) (BRASSINOSTEROID INSENSITIVE 1-like protein 3) Length = 1164 Score = 117 bits (294), Expect = 1e-26 Identities = 65/159 (40%), Positives = 97/159 (61%), Gaps = 8/159 (5%) Frame = +3 Query: 6 ERFQVYEFMENGSLKDHLHSS---GKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGD 176 ER VYE+M+ GSL+ LH G + L W R +IAI A L +LH C P + H D Sbjct: 926 ERLLVYEYMKYGSLETVLHEKTKKGGIFLDWSARKKIAIGAARGLAFLHHSCIPHIIHRD 985 Query: 177 IKPSNVLLDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTA 356 +K SNVLLD++++A+++ G+A + +T + + + TPGYV PEY + TA Sbjct: 986 MKSSNVLLDQDFVARVSDFGMARLVSALDTHLSVS----TLAGTPGYVPPEYYQSFRCTA 1041 Query: 357 KSDVYSYGVLLLELVTGRPVVQ-----DDRSLVEWSREL 458 K DVYSYGV+LLEL++G+ + +D +LV W+++L Sbjct: 1042 KGDVYSYGVILLELLSGKKPIDPEEFGEDNNLVGWAKQL 1080
>NORK_MEDTR (Q8L4H4) Nodulation receptor kinase precursor (EC 2.7.11.1) (Does not| make infections protein 2) (Symbiosis receptor-like kinase) (MtSYMRK) Length = 925 Score = 117 bits (292), Expect = 2e-26 Identities = 62/151 (41%), Positives = 96/151 (63%), Gaps = 3/151 (1%) Frame = +3 Query: 6 ERFQVYEFMENGSLKDHLH--SSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDI 179 ++ VY FM NGSL D L+ +S + +L W R+ IA+ A L YLH + + H D+ Sbjct: 664 QQILVYPFMSNGSLLDRLYGEASKRKILDWPTRLSIALGAARGLAYLHTFPGRSVIHRDV 723 Query: 180 KPSNVLLDKNYLAKLAGCGIA-HCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTA 356 K SN+LLD++ AK+A G + + G++ V +++++ T GY+DPEY TQ+L+ Sbjct: 724 KSSNILLDQSMCAKVADFGFSKYAPQEGDSYV-----SLEVRGTAGYLDPEYYKTQQLSE 778 Query: 357 KSDVYSYGVLLLELVTGRPVVQDDRSLVEWS 449 KSDV+S+GV+LLE+V+GR + R +EWS Sbjct: 779 KSDVFSFGVVLLEIVSGREPLNIKRPRIEWS 809
>NORK_PEA (Q8LKZ1) Nodulation receptor kinase precursor (EC 2.7.11.1)| Length = 924 Score = 115 bits (287), Expect = 7e-26 Identities = 62/151 (41%), Positives = 94/151 (62%), Gaps = 3/151 (1%) Frame = +3 Query: 6 ERFQVYEFMENGSLKDHLHS--SGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDI 179 ++ VY FM NGSL D L+ + + +L W R+ IA+ A L YLH + + H D+ Sbjct: 663 QQILVYPFMSNGSLLDRLYGEPAKRKILDWPTRLSIALGAARGLAYLHTFPGRSVIHRDV 722 Query: 180 KPSNVLLDKNYLAKLAGCGIA-HCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTA 356 K SN+LLD + AK+A G + + G++ V +++++ T GY+DPEY TQ+L+ Sbjct: 723 KSSNILLDHSMCAKVADFGFSKYAPQEGDSYV-----SLEVRGTAGYLDPEYYKTQQLSE 777 Query: 357 KSDVYSYGVLLLELVTGRPVVQDDRSLVEWS 449 KSDV+S+GV+LLE+V+GR + R VEWS Sbjct: 778 KSDVFSFGVVLLEIVSGREPLNIKRPRVEWS 808
>BRL1_ARATH (Q9ZWC8) Serine/threonine-protein kinase BRI1-like 1 precursor (EC| 2.7.11.1) (BRASSINOSTEROID INSENSITIVE 1-like protein 1) Length = 1166 Score = 114 bits (284), Expect = 2e-25 Identities = 65/160 (40%), Positives = 96/160 (60%), Gaps = 9/160 (5%) Frame = +3 Query: 6 ERFQVYEFMENGSLKDHLHSS----GKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHG 173 ER VYE+M+ GSL+ LH G + L W R +IAI A L +LH C P + H Sbjct: 927 ERLLVYEYMKWGSLETVLHEKSSKKGGIYLNWAARKKIAIGAARGLAFLHHSCIPHIIHR 986 Query: 174 DIKPSNVLLDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELT 353 D+K SNVLLD+++ A+++ G+A + +T + + + TPGYV PEY + T Sbjct: 987 DMKSSNVLLDEDFEARVSDFGMARLVSALDTHLSVS----TLAGTPGYVPPEYYQSFRCT 1042 Query: 354 AKSDVYSYGVLLLELVTGRPVVQ-----DDRSLVEWSREL 458 AK DVYSYGV+LLEL++G+ + +D +LV W+++L Sbjct: 1043 AKGDVYSYGVILLELLSGKKPIDPGEFGEDNNLVGWAKQL 1082
>BRI1_ARATH (O22476) BRASSINOSTEROID INSENSITIVE 1 precursor (EC 2.7.11.1)| (AtBRI1) (Brassinosteroid LRR receptor kinase) Length = 1196 Score = 114 bits (284), Expect = 2e-25 Identities = 66/156 (42%), Positives = 91/156 (58%), Gaps = 6/156 (3%) Frame = +3 Query: 6 ERFQVYEFMENGSLKDHLHSSGK--LLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDI 179 ER VYEFM+ GSL+D LH K + L W R +IAI A L +LH C P + H D+ Sbjct: 951 ERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAFLHHNCSPHIIHRDM 1010 Query: 180 KPSNVLLDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAK 359 K SNVLLD+N A+++ G+A + +T + + + TPGYV PEY + + K Sbjct: 1011 KSSNVLLDENLEARVSDFGMARLMSAMDTHLSVS----TLAGTPGYVPPEYYQSFRCSTK 1066 Query: 360 SDVYSYGVLLLELVTGRPVVQD----DRSLVEWSRE 455 DVYSYGV+LLEL+TG+ D +LV W ++ Sbjct: 1067 GDVYSYGVVLLELLTGKRPTDSPDFGDNNLVGWVKQ 1102
>APK1B_ARATH (P46573) Protein kinase APK1B, chloroplast precursor (EC 2.7.11.1)| Length = 412 Score = 113 bits (283), Expect = 2e-25 Identities = 68/158 (43%), Positives = 91/158 (57%), Gaps = 7/158 (4%) Frame = +3 Query: 9 RFQVYEFMENGSLKDHLHSSGKLLLP--WKNRIQIAIDVANALEYLHFYCDPPLYHGDIK 182 R VYEFM GSL++HL G P W R+++A+ A L +LH + + + D K Sbjct: 148 RLLVYEFMPRGSLENHLFRRGSYFQPLSWTLRLKVALGAAKGLAFLH-NAETSVIYRDFK 206 Query: 183 PSNVLLDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKS 362 SN+LLD Y AKL+ G+A G+ ST +I T GY PEY+ T LT KS Sbjct: 207 TSNILLDSEYNAKLSDFGLAKDGPTGDKSHVST----RIMGTYGYAAPEYLATGHLTTKS 262 Query: 363 DVYSYGVLLLELVTGRPVVQDDR-----SLVEWSRELI 461 DVYSYGV+LLE+++GR V +R LVEW+R L+ Sbjct: 263 DVYSYGVVLLEVLSGRRAVDKNRPPGEQKLVEWARPLL 300
>NAK_ARATH (P43293) Probable serine/threonine-protein kinase NAK (EC 2.7.11.1)| Length = 389 Score = 113 bits (282), Expect = 3e-25 Identities = 64/155 (41%), Positives = 90/155 (58%), Gaps = 7/155 (4%) Frame = +3 Query: 9 RFQVYEFMENGSLKDHLHSSGKLLLP--WKNRIQIAIDVANALEYLHFYCDPPLYHGDIK 182 R VYEFM GSL++HL G P W R+++A+ A L +LH P + + D K Sbjct: 147 RLLVYEFMTRGSLENHLFRRGTFYQPLSWNTRVRMALGAARGLAFLH-NAQPQVIYRDFK 205 Query: 183 PSNVLLDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKS 362 SN+LLD NY AKL+ G+A G+ ST ++ T GY PEY+ T L+ KS Sbjct: 206 ASNILLDSNYNAKLSDFGLARDGPMGDNSHVST----RVMGTQGYAAPEYLATGHLSVKS 261 Query: 363 DVYSYGVLLLELVTGRPVVQ-----DDRSLVEWSR 452 DVYS+GV+LLEL++GR + + +LV+W+R Sbjct: 262 DVYSFGVVLLELLSGRRAIDKNQPVGEHNLVDWAR 296
>KPRO_MAIZE (P17801) Putative receptor protein kinase ZmPK1 precursor (EC| 2.7.11.1) Length = 817 Score = 111 bits (277), Expect = 1e-24 Identities = 62/137 (45%), Positives = 83/137 (60%), Gaps = 1/137 (0%) Frame = +3 Query: 9 RFQVYEFMENGSLKDHLHSSG-KLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKP 185 R V E++ENGSL + L S G +LL W+ R IA+ VA L YLH C + H D+KP Sbjct: 602 RLLVSEYVENGSLANILFSEGGNILLDWEGRFNIALGVAKGLAYLHHECLEWVIHCDVKP 661 Query: 186 SNVLLDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSD 365 N+LLD+ + K+ G+ N G GST ++ T GY+ PE+V + +TAK D Sbjct: 662 ENILLDQAFEPKITDFGLVKLLNRG----GSTQNVSHVRGTLGYIAPEWVSSLPITAKVD 717 Query: 366 VYSYGVLLLELVTGRPV 416 VYSYGV+LLEL+TG V Sbjct: 718 VYSYGVVLLELLTGTRV 734
>BRI1_LYCPE (Q8L899) Systemin receptor SR160 precursor (EC 2.7.11.1)| (Brassinosteroid LRR receptor kinase) Length = 1207 Score = 111 bits (277), Expect = 1e-24 Identities = 65/153 (42%), Positives = 89/153 (58%), Gaps = 6/153 (3%) Frame = +3 Query: 6 ERFQVYEFMENGSLKDHLHSSGK--LLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDI 179 ER VYE+M+ GSL+D LH K + L W R +IAI A L +LH C P + H D+ Sbjct: 956 ERLLVYEYMKYGSLEDVLHDRKKTGIKLNWPARRKIAIGAARGLAFLHHNCIPHIIHRDM 1015 Query: 180 KPSNVLLDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAK 359 K SNVLLD+N A+++ G+A + +T + + + TPGYV PEY + + K Sbjct: 1016 KSSNVLLDENLEARVSDFGMARLMSAMDTHLSVS----TLAGTPGYVPPEYYQSFRCSTK 1071 Query: 360 SDVYSYGVLLLELVTGRPVVQD----DRSLVEW 446 DVYSYGV+LLEL+TG+ D +LV W Sbjct: 1072 GDVYSYGVVLLELLTGKQPTDSADFGDNNLVGW 1104
>BRI1_LYCES (Q8GUQ5) Brassinosteroid LRR receptor kinase precursor (EC 2.7.11.1)| (tBRI1) (Altered brassinolide sensitivity 1) (Systemin receptor SR160) Length = 1207 Score = 111 bits (277), Expect = 1e-24 Identities = 65/153 (42%), Positives = 89/153 (58%), Gaps = 6/153 (3%) Frame = +3 Query: 6 ERFQVYEFMENGSLKDHLHSSGKL--LLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDI 179 ER VYE+M+ GSL+D LH K+ L W R +IAI A L +LH C P + H D+ Sbjct: 956 ERLLVYEYMKYGSLEDVLHDRKKIGIKLNWPARRKIAIGAARGLAFLHHNCIPHIIHRDM 1015 Query: 180 KPSNVLLDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAK 359 K SNVLLD+N A+++ G+A + +T + + + TPGYV PEY + + K Sbjct: 1016 KSSNVLLDENLEARVSDFGMARLMSAMDTHLSVS----TLAGTPGYVPPEYYQSFRCSTK 1071 Query: 360 SDVYSYGVLLLELVTGRPVVQD----DRSLVEW 446 DVYSYGV+LLEL+TG+ D +LV W Sbjct: 1072 GDVYSYGVVLLELLTGKQPTDSADFGDNNLVGW 1104
>APK1A_ARATH (Q06548) Protein kinase APK1A, chloroplast precursor (EC 2.7.11.1)| Length = 410 Score = 110 bits (276), Expect = 1e-24 Identities = 67/155 (43%), Positives = 90/155 (58%), Gaps = 7/155 (4%) Frame = +3 Query: 9 RFQVYEFMENGSLKDHLHSSGKLLLP--WKNRIQIAIDVANALEYLHFYCDPPLYHGDIK 182 R VYEFM GSL++HL G P WK R+++A+ A L +LH +Y D K Sbjct: 147 RLLVYEFMPRGSLENHLFRRGLYFQPLSWKLRLKVALGAAKGLAFLHSSETRVIYR-DFK 205 Query: 183 PSNVLLDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKS 362 SN+LLD Y AKL+ G+A G+ ST ++ T GY PEY+ T LT KS Sbjct: 206 TSNILLDSEYNAKLSDFGLAKDGPIGDKSHVST----RVMGTHGYAAPEYLATGHLTTKS 261 Query: 363 DVYSYGVLLLELVTGRPVV-----QDDRSLVEWSR 452 DVYS+GV+LLEL++GR V +R+LVEW++ Sbjct: 262 DVYSFGVVLLELLSGRRAVDKNRPSGERNLVEWAK 296
>PSKR_ARATH (Q9ZVR7) Putative phytosulfokine receptor precursor (EC 2.7.11.1)| (Phytosulfokine LRR receptor kinase) Length = 1008 Score = 110 bits (276), Expect = 1e-24 Identities = 67/154 (43%), Positives = 88/154 (57%), Gaps = 7/154 (4%) Frame = +3 Query: 6 ERFQVYEFMENGSLKDHLH--SSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDI 179 +R +Y +MENGSL LH + G LL WK R++IA A L YLH CDP + H DI Sbjct: 802 DRLLIYSYMENGSLDYWLHERNDGPALLKWKTRLRIAQGAAKGLLYLHEGCDPHILHRDI 861 Query: 180 KPSNVLLDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAK 359 K SN+LLD+N+ + LA G+A + T V + + T GY+ PEY T K Sbjct: 862 KSSNILLDENFNSHLADFGLARLMSPYETHV-----STDLVGTLGYIPPEYGQASVATYK 916 Query: 360 SDVYSYGVLLLELVTG-RPV----VQDDRSLVEW 446 DVYS+GV+LLEL+T RPV + R L+ W Sbjct: 917 GDVYSFGVVLLELLTDKRPVDMCKPKGCRDLISW 950
>TMK1_ARATH (P43298) Putative receptor protein kinase TMK1 precursor (EC| 2.7.11.1) Length = 942 Score = 108 bits (270), Expect = 7e-24 Identities = 61/159 (38%), Positives = 87/159 (54%), Gaps = 8/159 (5%) Frame = +3 Query: 6 ERFQVYEFMENGSLKDHLHS---SGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGD 176 E+ VYE+M G+L HL G L WK R+ +A+DVA +EYLH H D Sbjct: 658 EKLLVYEYMPQGTLSRHLFEWSEEGLKPLLWKQRLTLALDVARGVEYLHGLAHQSFIHRD 717 Query: 177 IKPSNVLLDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTA 356 +KPSN+LL + AK+A G+ + G + +I T GY+ PEY VT +T Sbjct: 718 LKPSNILLGDDMRAKVADFGLVRLAPEGKGSI-----ETRIAGTFGYLAPEYAVTGRVTT 772 Query: 357 KSDVYSYGVLLLELVTGRPVVQDDR-----SLVEWSREL 458 K DVYS+GV+L+EL+TGR + + + LV W + + Sbjct: 773 KVDVYSFGVILMELITGRKSLDESQPEESIHLVSWFKRM 811
>RPK1_IPONI (P93194) Receptor-like protein kinase precursor (EC 2.7.11.1)| Length = 1109 Score = 107 bits (268), Expect = 1e-23 Identities = 62/152 (40%), Positives = 84/152 (55%), Gaps = 5/152 (3%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLL-LPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNV 194 +Y +MENGSL D LH + L W R IA+ A+ L YLHF CDP + H DIKP N+ Sbjct: 889 LYTYMENGSLHDILHETNPPKPLDWSTRHNIAVGTAHGLAYLHFDCDPAIVHRDIKPMNI 948 Query: 195 LLDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVYS 374 LLD + ++ GIA + T + S +Q T GY+ PE T + +SDVYS Sbjct: 949 LLDSDLEPHISDFGIAKLLDQSATSIPSN----TVQGTIGYMAPENAFTTVKSRESDVYS 1004 Query: 375 YGVLLLELVTGR----PVVQDDRSLVEWSREL 458 YGV+LLEL+T + P + +V W R + Sbjct: 1005 YGVVLLELITRKKALDPSFNGETDIVGWVRSV 1036
>PSKR_DAUCA (Q8LPB4) Phytosulfokine receptor precursor (EC 2.7.11.1)| (Phytosulfokine LRR receptor kinase) Length = 1021 Score = 105 bits (262), Expect = 6e-23 Identities = 62/154 (40%), Positives = 84/154 (54%), Gaps = 7/154 (4%) Frame = +3 Query: 6 ERFQVYEFMENGSLKDHLHSS--GKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDI 179 ++ +Y +M+NGSL LH G L WK R++IA A L YLH C+P + H DI Sbjct: 811 DKLLIYSYMDNGSLDYWLHEKVDGPPSLDWKTRLRIARGAAEGLAYLHQSCEPHILHRDI 870 Query: 180 KPSNVLLDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAK 359 K SN+LL ++A LA G+A +T V T + T GY+ PEY T K Sbjct: 871 KSSNILLSDTFVAHLADFGLARLILPYDTHV-----TTDLVGTLGYIPPEYGQASVATYK 925 Query: 360 SDVYSYGVLLLELVTGRPVV-----QDDRSLVEW 446 DVYS+GV+LLEL+TGR + + R L+ W Sbjct: 926 GDVYSFGVVLLELLTGRRPMDVCKPRGSRDLISW 959
>BRL2_ARATH (Q9ZPS9) Serine/threonine-protein kinase BRI1-like 2 precursor (EC| 2.7.11.1) (BRASSINOSTEROID INSENSITIVE 1-like protein 2) (Protein VASCULAR HIGHWAY 1) Length = 1143 Score = 104 bits (259), Expect = 1e-22 Identities = 63/157 (40%), Positives = 94/157 (59%), Gaps = 8/157 (5%) Frame = +3 Query: 6 ERFQVYEFMENGSLKDHLHS----SGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHG 173 ER VYEFM+ GSL++ LH + +L W+ R +IA A L +LH C P + H Sbjct: 906 ERLLVYEFMQYGSLEEVLHGPRTGEKRRILGWEERKKIAKGAAKGLCFLHHNCIPHIIHR 965 Query: 174 DIKPSNVLLDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELT 353 D+K SNVLLD++ A+++ G+A + +T + + + TPGYV PEY + T Sbjct: 966 DMKSSNVLLDQDMEARVSDFGMARLISALDTHLSVST----LAGTPGYVPPEYYQSFRCT 1021 Query: 354 AKSDVYSYGVLLLELVTG-RPVVQD---DRSLVEWSR 452 AK DVYS GV++LE+++G RP ++ D +LV WS+ Sbjct: 1022 AKGDVYSIGVVMLEILSGKRPTDKEEFGDTNLVGWSK 1058
>CLV1_ARATH (Q9SYQ8) Receptor protein kinase CLAVATA1 precursor (EC 2.7.11.1)| Length = 980 Score = 102 bits (254), Expect = 5e-22 Identities = 57/148 (38%), Positives = 85/148 (57%), Gaps = 3/148 (2%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVL 197 +YE+M NGSL + LH S L W+ R ++A++ A L YLH C P + H D+K +N+L Sbjct: 765 LYEYMPNGSLGELLHGSKGGHLQWETRHRVAVEAAKGLCYLHHDCSPLILHRDVKSNNIL 824 Query: 198 LDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVYSY 377 LD ++ A +A G+A G ++ I + GY+ PEY T ++ KSDVYS+ Sbjct: 825 LDSDFEAHVADFGLAKFLVDG----AASECMSSIAGSYGYIAPEYAYTLKVDEKSDVYSF 880 Query: 378 GVLLLELVTGRPVV---QDDRSLVEWSR 452 GV+LLEL+ G+ V + +V W R Sbjct: 881 GVVLLELIAGKKPVGEFGEGVDIVRWVR 908
>BAK1_ARATH (Q94F62) BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1| precursor (EC 2.7.11.1) (BRI1-associated receptor kinase 1) (Somatic embryogenesis receptor-like kinase 3) Length = 615 Score = 102 bits (254), Expect = 5e-22 Identities = 59/161 (36%), Positives = 90/161 (55%), Gaps = 9/161 (5%) Frame = +3 Query: 6 ERFQVYEFMENGSLKDHLHSSGKLLLP--WKNRIQIAIDVANALEYLHFYCDPPLYHGDI 179 ER VY +M NGS+ L + P W R +IA+ A L YLH +CDP + H D+ Sbjct: 358 ERLLVYPYMANGSVASCLRERPESQPPLDWPKRQRIALGSARGLAYLHDHCDPKIIHRDV 417 Query: 180 KPSNVLLDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAK 359 K +N+LLD+ + A + G+A + +T V T ++ T G++ PEY+ T + + K Sbjct: 418 KAANILLDEEFEAVVGDFGLAKLMDYKDTHV-----TTAVRGTIGHIAPEYLSTGKSSEK 472 Query: 360 SDVYSYGVLLLELVTG-------RPVVQDDRSLVEWSRELI 461 +DV+ YGV+LLEL+TG R DD L++W + L+ Sbjct: 473 TDVFGYGVMLLELITGQRAFDLARLANDDDVMLLDWVKGLL 513
>EXS_ARATH (Q9LYN8) Leucine-rich repeat receptor protein kinase EXS precursor| (EC 2.7.11.1) (Extra sporogenous cells protein) (EXCESS MICROSPOROCYTES1 protein) Length = 1192 Score = 100 bits (248), Expect = 2e-21 Identities = 62/160 (38%), Positives = 87/160 (54%), Gaps = 8/160 (5%) Frame = +3 Query: 6 ERFQVYEFMENGSLKDHLHSSGKLL--LPWKNRIQIAIDVANALEYLHFYCDPPLYHGDI 179 E+ VYE+M NGSL L + +L L W R++IA+ A L +LH P + H DI Sbjct: 985 EKLLVYEYMVNGSLDHWLRNQTGMLEVLDWSKRLKIAVGAARGLAFLHHGFIPHIIHRDI 1044 Query: 180 KPSNVLLDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAK 359 K SN+LLD ++ K+A G+A + + V + I T GY+ PEY + T K Sbjct: 1045 KASNILLDGDFEPKVADFGLARLISACESHVSTV-----IAGTFGYIPPEYGQSARATTK 1099 Query: 360 SDVYSYGVLLLELVTGRPVVQDD------RSLVEWSRELI 461 DVYS+GV+LLELVTG+ D +LV W+ + I Sbjct: 1100 GDVYSFGVILLELVTGKEPTGPDFKESEGGNLVGWAIQKI 1139
>CX32_ARATH (P27450) Probable serine/threonine-protein kinase Cx32, chloroplast| precursor (EC 2.7.11.1) Length = 419 Score = 97.8 bits (242), Expect = 1e-20 Identities = 65/156 (41%), Positives = 83/156 (53%), Gaps = 7/156 (4%) Frame = +3 Query: 6 ERFQVYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKP 185 E VYEFM GSL+ HL PW RI+I I A L +LH +Y D K Sbjct: 164 ELLLVYEFMPKGSLESHLFRRNDPF-PWDLRIKIVIGAARGLAFLHSLQREVIYR-DFKA 221 Query: 186 SNVLLDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSD 365 SN+LLD NY AKL+ G+A + T +I T GY PEY+ T L KSD Sbjct: 222 SNILLDSNYDAKLSDFGLAKLGPADE----KSHVTTRIMGTYGYAAPEYMATGHLYVKSD 277 Query: 366 VYSYGVLLLELVTG-------RPVVQDDRSLVEWSR 452 V+++GV+LLE++TG RP Q+ SLV+W R Sbjct: 278 VFAFGVVLLEIMTGLTAHNTKRPRGQE--SLVDWLR 311
>IRAK1_MOUSE (Q62406) Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1)| (IRAK-1) (IRAK) (Pelle-like protein kinase) (mPLK) Length = 710 Score = 95.5 bits (236), Expect = 6e-20 Identities = 56/153 (36%), Positives = 84/153 (54%), Gaps = 5/153 (3%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLP--WKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSN 191 VY F+ NGSL+D LH + P W R+ I + A A+++LH P L HGDIK SN Sbjct: 287 VYGFLPNGSLEDQLHLQTQACSPLSWPQRLDILLGTARAIQFLH-QDSPSLIHGDIKSSN 345 Query: 192 VLLDKNYLAKLAGCGIAHCSN--GGNTMVGSTPG-TVKIQATPGYVDPEYVVTQELTAKS 362 VLLD+ + KL G+A S G ST T ++ T Y+ EY+ T L + Sbjct: 346 VLLDERLMPKLGDFGLARFSRFAGAKASQSSTVARTSTVRGTLAYLPEEYIKTGRLAVDT 405 Query: 363 DVYSYGVLLLELVTGRPVVQDDRSLVEWSRELI 461 D +S+GV++LE + G+ V+ + ++ ++LI Sbjct: 406 DTFSFGVVILETLAGQRAVRTQGAKTKYLKDLI 438
>IRAK1_HUMAN (P51617) Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1)| (IRAK-1) Length = 712 Score = 93.2 bits (230), Expect = 3e-19 Identities = 55/157 (35%), Positives = 84/157 (53%), Gaps = 9/157 (5%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLP--WKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSN 191 VY F+ NGSL+D LH + P W R+ I + A A+++LH P L HGDIK SN Sbjct: 287 VYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLH-QDSPSLIHGDIKSSN 345 Query: 192 VLLDKNYLAKLAGCGIAHCSNGGNTMVGSTPG-------TVKIQATPGYVDPEYVVTQEL 350 VLLD+ KL G+A S GS+P T ++ T Y+ EY+ T L Sbjct: 346 VLLDERLTPKLGDFGLARFSR----FAGSSPSQSSMVARTQTVRGTLAYLPEEYIKTGRL 401 Query: 351 TAKSDVYSYGVLLLELVTGRPVVQDDRSLVEWSRELI 461 +D +S+GV++LE + G+ V+ + ++ ++L+ Sbjct: 402 AVDTDTFSFGVVVLETLAGQRAVKTHGARTKYLKDLV 438
>IRAK4_MOUSE (Q8R4K2) Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1)| (IRAK-4) Length = 459 Score = 92.8 bits (229), Expect = 4e-19 Identities = 56/139 (40%), Positives = 80/139 (57%), Gaps = 1/139 (0%) Frame = +3 Query: 18 VYEFMENGSLKDHLHS-SGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNV 194 VY +M NGSL D L G L W R ++A AN + +LH + H DIK +N+ Sbjct: 261 VYAYMPNGSLLDRLSCLDGTPPLSWHTRCKVAQGTANGIRFLH---ENHHIHRDIKSANI 317 Query: 195 LLDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVYS 374 LLDK++ AK++ G+A S + T T +I T Y+ PE + E+T KSD+YS Sbjct: 318 LLDKDFTAKISDFGLARAS----ARLAQTVMTSRIVGTTAYMAPE-ALRGEITPKSDIYS 372 Query: 375 YGVLLLELVTGRPVVQDDR 431 +GV+LLEL+TG V ++R Sbjct: 373 FGVVLLELITGLAAVDENR 391
>IRAK4_HUMAN (Q9NWZ3) Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1)| (IRAK-4) (NY-REN-64 antigen) Length = 460 Score = 90.1 bits (222), Expect = 3e-18 Identities = 56/139 (40%), Positives = 78/139 (56%), Gaps = 1/139 (0%) Frame = +3 Query: 18 VYEFMENGSLKDHLHS-SGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNV 194 VY +M NGSL D L G L W R +IA AN + +LH + H DIK +N+ Sbjct: 261 VYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLH---ENHHIHRDIKSANI 317 Query: 195 LLDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVYS 374 LLD+ + AK++ G+A S T T +I T Y+ PE + E+T KSD+YS Sbjct: 318 LLDEAFTAKISDFGLARASE----KFAQTVMTSRIVGTTAYMAPE-ALRGEITPKSDIYS 372 Query: 375 YGVLLLELVTGRPVVQDDR 431 +GV+LLE++TG P V + R Sbjct: 373 FGVVLLEIITGLPAVDEHR 391
>SRK6_BRAOE (Q09092) Putative serine/threonine-protein kinase receptor| precursor (EC 2.7.11.1) (S-receptor kinase) (SRK) Length = 849 Score = 89.7 bits (221), Expect = 3e-18 Identities = 51/136 (37%), Positives = 77/136 (56%), Gaps = 1/136 (0%) Frame = +3 Query: 6 ERFQVYEFMENGSLKDHLHS-SGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIK 182 E+ +YE++EN SL +L + + L W R I VA L YLH + H D+K Sbjct: 596 EKMLIYEYLENLSLDSYLFGKTRRSKLNWNERFDITNGVARGLLYLHQDSRFRIIHRDLK 655 Query: 183 PSNVLLDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKS 362 SN+LLDKN + K++ G+A T T+K+ T GY+ PEY + + KS Sbjct: 656 VSNILLDKNMIPKISDFGMARIFERDETEAN----TMKVVGTYGYMSPEYAMYGIFSEKS 711 Query: 363 DVYSYGVLLLELVTGR 410 DV+S+GV++LE+V+G+ Sbjct: 712 DVFSFGVIVLEIVSGK 727
>RIPK3_MOUSE (Q9QZL0) Receptor-interacting serine/threonine-protein kinase 3 (EC| 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) (mRIP3) Length = 486 Score = 82.4 bits (202), Expect = 5e-16 Identities = 54/141 (38%), Positives = 74/141 (52%), Gaps = 2/141 (1%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVL 197 V FMENGSL L + PW ++ +V + YLH DPPL H D+KPSN+L Sbjct: 94 VTRFMENGSLAGLLQP--ECPRPWPLLCRLLQEVVLGMCYLHSL-DPPLLHRDLKPSNIL 150 Query: 198 LDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAK--SDVY 371 LD AKLA G++ G + GS G+ T Y+DPE + L A SDVY Sbjct: 151 LDPELHAKLADFGLSTFQGGSQSGSGSGSGSRDSGGTLAYLDPELLFKVNLKASKASDVY 210 Query: 372 SYGVLLLELVTGRPVVQDDRS 434 S+G+L+ ++ GR D++ Sbjct: 211 SFGILVWAVLAGREAELVDKT 231
>TMKL1_ARATH (P33543) Putative kinase-like protein TMKL1 precursor| Length = 674 Score = 82.0 bits (201), Expect = 7e-16 Identities = 49/138 (35%), Positives = 77/138 (55%), Gaps = 3/138 (2%) Frame = +3 Query: 6 ERFQVYEFMENGSLKDHLHSSG--KLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDI 179 E+ +Y+++ N SL D LH S K L W R +IA+ +A L YLH + P+ HG+I Sbjct: 442 EKLLIYDYLPNISLHDLLHESKPRKPALNWARRHKIALGIARGLAYLHTGQEVPIIHGNI 501 Query: 180 KPSNVLLDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQA-TPGYVDPEYVVTQELTA 356 + NVL+D + A+L G+ MV + + QA + GY PE ++ Sbjct: 502 RSKNVLVDDFFFARLTEFGL------DKIMVQAVADEIVSQAKSDGYKAPELHKMKKCNP 555 Query: 357 KSDVYSYGVLLLELVTGR 410 +SDVY++G+LLLE++ G+ Sbjct: 556 RSDVYAFGILLLEILMGK 573
>KPEL_DROME (Q05652) Probable serine/threonine-protein kinase pelle (EC| 2.7.11.1) Length = 501 Score = 81.3 bits (199), Expect = 1e-15 Identities = 49/137 (35%), Positives = 75/137 (54%), Gaps = 4/137 (2%) Frame = +3 Query: 18 VYEFMENGSLKDHL--HSSGKLL--LPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKP 185 VY+ M+ GSL+ L H + L L W+ R I++ A + +LH PL HGDIKP Sbjct: 290 VYQLMKGGSLEARLRAHKAQNPLPALTWQQRFSISLGTARGIYFLHTARGTPLIHGDIKP 349 Query: 186 SNVLLDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSD 365 +N+LLD+ K+ G+ G + + K+ T Y+ PE+ ++L+ D Sbjct: 350 ANILLDQCLQPKIGDFGLV---REGPKSLDAVVEVNKVFGTKIYLPPEFRNFRQLSTGVD 406 Query: 366 VYSYGVLLLELVTGRPV 416 VYS+G++LLE+ TGR V Sbjct: 407 VYSFGIVLLEVFTGRQV 423
>IRAK2_HUMAN (O43187) Interleukin-1 receptor-associated kinase-like 2 (IRAK-2)| Length = 590 Score = 80.1 bits (196), Expect = 3e-15 Identities = 48/142 (33%), Positives = 78/142 (54%), Gaps = 1/142 (0%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKL-LLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNV 194 +Y +M NGSL+D L G LPW R+ I + A+EYLH + H ++K SNV Sbjct: 285 IYPYMANGSLQDRLQGQGGSDPLPWPQRVSICSGLLCAVEYLHGL---EIIHSNVKSSNV 341 Query: 195 LLDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVYS 374 LLD+N KLA +AH + T ++ + Y+ +++ +LT + D++S Sbjct: 342 LLDQNLTPKLAH-PMAHLCPVNKRSKYTMMKTHLLRTSAAYLPEDFIRVGQLTKRVDIFS 400 Query: 375 YGVLLLELVTGRPVVQDDRSLV 440 G++L E++TG P + ++RS V Sbjct: 401 CGIVLAEVLTGIPAMDNNRSPV 422
>IRAK3_HUMAN (Q9Y616) Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1)| (IRAK-3) (IL-1 receptor-associated kinase M) (IRAK-M) Length = 596 Score = 79.0 bits (193), Expect = 6e-15 Identities = 47/138 (34%), Positives = 72/138 (52%), Gaps = 1/138 (0%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLL-LPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNV 194 +Y +M NG+L D L G LPW RI I I ++ A+ YLH + G I +N+ Sbjct: 240 IYPYMRNGTLFDRLQCVGDTAPLPWHIRIGILIGISKAIHYLHNVQPCSVICGSISSANI 299 Query: 195 LLDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVYS 374 LLD + KL +AH + + T Y+ EY+ +L+ K+DVYS Sbjct: 300 LLDDQFQPKLTDFAMAHFRSHLEHQSCTINMTSSSSKHLWYMPEEYIRQGKLSIKTDVYS 359 Query: 375 YGVLLLELVTGRPVVQDD 428 +G++++E++TG VV DD Sbjct: 360 FGIVIMEVLTGCRVVLDD 377
>IRAK3_MOUSE (Q8K4B2) Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1)| (IRAK-3) (IL-1 receptor-associated kinase M) (IRAK-M) Length = 609 Score = 77.4 bits (189), Expect = 2e-14 Identities = 47/143 (32%), Positives = 74/143 (51%), Gaps = 1/143 (0%) Frame = +3 Query: 18 VYEFMENGSLKDHLH-SSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNV 194 VY +M NG+L D L ++G L W RI + I +A A++YLH + G++ +N+ Sbjct: 253 VYPYMSNGTLFDRLQCTNGTTPLSWHVRISVLIGIAKAIQYLHNTQPCAVICGNVSSANI 312 Query: 195 LLDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVYS 374 LLD KL AH + T + Y+ EY+ L+ K+DVYS Sbjct: 313 LLDDQLQPKLTDFAAAHFRPNLEQQSSTINMTGGGRKHLWYMPEEYIRQGRLSVKTDVYS 372 Query: 375 YGVLLLELVTGRPVVQDDRSLVE 443 +G++++E++TG VV DD V+ Sbjct: 373 FGIVIMEVLTGCKVVLDDPKHVQ 395
>CTR1_ARATH (Q05609) Serine/threonine-protein kinase CTR1 (EC 2.7.11.1)| Length = 821 Score = 77.4 bits (189), Expect = 2e-14 Identities = 48/130 (36%), Positives = 71/130 (54%), Gaps = 1/130 (0%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSG-KLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNV 194 V E++ GSL LH SG + L + R+ +A DVA + YLH +PP+ H D+K N+ Sbjct: 624 VTEYLSRGSLYRLLHKSGAREQLDERRRLSMAYDVAKGMNYLHNR-NPPIVHRDLKSPNL 682 Query: 195 LLDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVYS 374 L+DK Y K+ G++ +T + S TP ++ PE + + KSDVYS Sbjct: 683 LVDKKYTVKVCDFGLSRLK--ASTFLSSKSAA----GTPEWMAPEVLRDEPSNEKSDVYS 736 Query: 375 YGVLLLELVT 404 +GV+L EL T Sbjct: 737 FGVILWELAT 746
>PKNX_STRCO (Q9XA16) Probable serine/threonine-protein kinase SCO3848 (EC| 2.7.11.1) Length = 673 Score = 76.6 bits (187), Expect = 3e-14 Identities = 50/133 (37%), Positives = 76/133 (57%), Gaps = 1/133 (0%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVL 197 V E+++ +L++ LHS G+ LLP + +++ I + ALEY H + H DIKP+NV+ Sbjct: 91 VMEYVDGSTLRELLHS-GRKLLP-ERTLEMTIGILQALEYSH---RAGIVHRDIKPANVM 145 Query: 198 LDKNYLAKLAGCGIAHC-SNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVYS 374 L +N K+ GIA + G TM T + T Y+ PE +++ A+SD+YS Sbjct: 146 LTRNGQVKVMDFGIARAMGDSGMTMTQ----TAAVIGTAQYLSPEQAKGEQVDARSDLYS 201 Query: 375 YGVLLLELVTGRP 413 G LL EL+T RP Sbjct: 202 TGCLLYELLTVRP 214
>RIPK4_HUMAN (P57078) Receptor-interacting serine/threonine-protein kinase 4 (EC| 2.7.11.1) (Ankyrin repeat domain protein 3) (PKC-delta-interacting protein kinase) Length = 832 Score = 73.6 bits (179), Expect = 3e-13 Identities = 46/143 (32%), Positives = 79/143 (55%), Gaps = 2/143 (1%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVL 197 V E+ME GSL+ L S LPW R +I + A + +LH PPL H D+KP+N+L Sbjct: 95 VMEYMETGSLEKLLASEP---LPWDLRFRIIHETAVGMNFLHCMA-PPLLHLDLKPANIL 150 Query: 198 LDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYV--VTQELTAKSDVY 371 LD +Y K++ G+A C+ ++ S G + T Y+ PE + ++ K DVY Sbjct: 151 LDAHYHVKISDFGLAKCNGLSHSHDLSMDG---LFGTIAYLPPERIREKSRLFDTKHDVY 207 Query: 372 SYGVLLLELVTGRPVVQDDRSLV 440 S+ +++ ++T + D+++++ Sbjct: 208 SFAIVIWGVLTQKKPFADEKNIL 230
>YR831_MIMIV (Q7T6Y2) Putative serine/threonine-protein kinase/receptor R831| precursor (EC 2.7.11.1) Length = 1624 Score = 72.8 bits (177), Expect = 4e-13 Identities = 40/131 (30%), Positives = 74/131 (56%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVL 197 V E+M G+L+D L + + + + N++++ A ++YLH +P + H DIKP+N+L Sbjct: 1437 VTEYMRMGNLRDVLKNPD-IKITFANKLKLLYGAAMGIDYLHS-SNPMIVHRDIKPANIL 1494 Query: 198 LDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVYSY 377 +D+++ K+A G A TM TP + PE + ++ K+DV+S+ Sbjct: 1495 VDEHFNVKIADFGFARIKEDNTTMTRC--------GTPCWTAPEVIRGEKYCEKADVFSF 1546 Query: 378 GVLLLELVTGR 410 GV++ E++TG+ Sbjct: 1547 GVVMWEVLTGK 1557 Score = 48.5 bits (114), Expect = 9e-06 Identities = 37/131 (28%), Positives = 64/131 (48%), Gaps = 2/131 (1%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVL 197 V EFM GSL D L + +P+ +I++A + + +LH + H D+K N+L Sbjct: 859 VMEFMSLGSLYDLLGNELIPEIPYALKIKMAYQASKGMHFLH---SSGIVHRDLKSLNLL 915 Query: 198 LDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYV--VTQELTAKSDVY 371 LD + K++ G+ + + I T ++ PE + T+ +DVY Sbjct: 916 LDSKWNVKVSDFGLTKV----KSELDKKKTNDNIIGTIHWIAPEILNDSTEVDYILADVY 971 Query: 372 SYGVLLLELVT 404 S+G++L EL+T Sbjct: 972 SFGIILWELLT 982
>RIPK3_RAT (Q9Z2P5) Receptor-interacting serine/threonine-protein kinase 3 (EC| 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) (Homocysteine respondent protein HCYP2) Length = 478 Score = 72.4 bits (176), Expect = 6e-13 Identities = 55/140 (39%), Positives = 73/140 (52%), Gaps = 2/140 (1%) Frame = +3 Query: 27 FMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVLLDK 206 FMENGSL L S PW ++ +V + YLH +P L H D+KPSNVLLD Sbjct: 97 FMENGSLSGLLQPSCPR--PWPLLCRLLEEVVLGMCYLHSL-NPSLLHRDLKPSNVLLDL 153 Query: 207 NYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAK-SDVYSYGV 383 AKLA G++ G + GS G+ T Y+ PE + +K SDVYS+GV Sbjct: 154 ELHAKLADFGLSTFQGGSQS--GSGSGSRDSGGTLAYLAPELLDNDGKASKASDVYSFGV 211 Query: 384 LLLELVTGRPV-VQDDRSLV 440 L+ ++ GR V D SL+ Sbjct: 212 LVWTVLAGREAEVVDKTSLI 231
>RIPK3_HUMAN (Q9Y572) Receptor-interacting serine/threonine-protein kinase 3 (EC| 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) Length = 518 Score = 72.4 bits (176), Expect = 6e-13 Identities = 52/136 (38%), Positives = 72/136 (52%), Gaps = 3/136 (2%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVL 197 V +FMENGSL L S + PW ++ +V + YLH +P L H D+KPSNVL Sbjct: 93 VTKFMENGSLSGLLQS--QCPRPWPLLCRLLKEVVLGMFYLHDQ-NPVLLHRDLKPSNVL 149 Query: 198 LDKNYLAKLAGCGIAHCSNGGNTMVGS-TPGTVKIQATPGYVDPEYV--VTQELTAKSDV 368 D KLA G++ G + GS PG T GY+ PE V ++ + SDV Sbjct: 150 PDPELHVKLADFGLSTFQGGSQSGTGSGEPG-----GTLGYLAPELFVNVNRKASTASDV 204 Query: 369 YSYGVLLLELVTGRPV 416 YS+G+L+ ++ GR V Sbjct: 205 YSFGILMWAVLAGREV 220
>PKSC_STRCO (Q9S2C0) Serine/threonine protein kinase pksC (EC 2.7.11.1)| Length = 556 Score = 70.9 bits (172), Expect = 2e-12 Identities = 42/110 (38%), Positives = 60/110 (54%) Frame = +3 Query: 81 LPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVLLDKNYLAKLAGCGIAHCSNGG 260 +P ++I DV ALE H + L H DIKP NV++ K + K+ GIA G Sbjct: 123 MPADKALKITADVLAALEISH---EMGLVHRDIKPGNVMMTKRGVVKVMDFGIARAMQSG 179 Query: 261 NTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVYSYGVLLLELVTGR 410 T + T V TP Y+ PE + + + A+SD+YS G++L +LVTGR Sbjct: 180 VTSMTQTGMVV---GTPQYLSPEQALGRGVDARSDLYSVGIMLFQLVTGR 226
>M3LK7_DROME (P83104) Putative mitogen-activated protein kinase kinase kinase| 7-like (EC 2.7.11.25) Length = 393 Score = 70.5 bits (171), Expect = 2e-12 Identities = 45/132 (34%), Positives = 72/132 (54%), Gaps = 1/132 (0%) Frame = +3 Query: 12 FQVYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSN 191 + + E++E GSL ++L+ K + ++ A+ A AL YLH D P+ H DIKP N Sbjct: 80 YLLMEYLEEGSLHNYLYGDDKWEYTVEQAVRWALQCAKALAYLHSL-DRPIVHRDIKPQN 138 Query: 192 VLL-DKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDV 368 +LL +++ K+ G+A + T +Q T Y+ PE + + TAK DV Sbjct: 139 MLLYNQHEDLKICDFGLATDMSNNKT---------DMQGTLRYMAPEAIKHLKYTAKCDV 189 Query: 369 YSYGVLLLELVT 404 YS+G++L EL+T Sbjct: 190 YSFGIMLWELMT 201
>PKNB_MYCLE (P54744) Probable serine/threonine-protein kinase pknB (EC| 2.7.11.1) Length = 622 Score = 68.2 bits (165), Expect = 1e-11 Identities = 40/132 (30%), Positives = 65/132 (49%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVL 197 V E+++ +L+D +H+ G + P + I+I D AL + H + H D+KP+N++ Sbjct: 91 VMEYVDGATLRDIVHTDGPM--PPQQAIEIVADACQALNFSH---QNGIIHRDVKPANIM 145 Query: 198 LDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVYSY 377 + K+ GIA S T + T Y+ PE + A+SDVYS Sbjct: 146 ISATNAVKVMDFGIARAIADST----SVTQTAAVIGTAQYLSPEQARGDSVDARSDVYSL 201 Query: 378 GVLLLELVTGRP 413 G +L E++TG P Sbjct: 202 GCVLYEILTGEP 213
>PKNB_MYCTU (P0A5S4) Probable serine/threonine-protein kinase pknB (EC| 2.7.11.1) Length = 626 Score = 67.8 bits (164), Expect = 1e-11 Identities = 42/138 (30%), Positives = 69/138 (50%), Gaps = 1/138 (0%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVL 197 V E+++ +L+D +H+ G + K I++ D AL + H + H D+KP+N++ Sbjct: 91 VMEYVDGVTLRDIVHTEGPMTP--KRAIEVIADACQALNFSH---QNGIIHRDVKPANIM 145 Query: 198 LDKNYLAKLAGCGIAHC-SNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVYS 374 + K+ GIA ++ GN S T + T Y+ PE + A+SDVYS Sbjct: 146 ISATNAVKVMDFGIARAIADSGN----SVTQTAAVIGTAQYLSPEQARGDSVDARSDVYS 201 Query: 375 YGVLLLELVTGRPVVQDD 428 G +L E++TG P D Sbjct: 202 LGCVLYEVLTGEPPFTGD 219
>PKNB_MYCBO (P0A5S5) Probable serine/threonine-protein kinase pknB (EC| 2.7.11.1) Length = 626 Score = 67.8 bits (164), Expect = 1e-11 Identities = 42/138 (30%), Positives = 69/138 (50%), Gaps = 1/138 (0%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVL 197 V E+++ +L+D +H+ G + K I++ D AL + H + H D+KP+N++ Sbjct: 91 VMEYVDGVTLRDIVHTEGPMTP--KRAIEVIADACQALNFSH---QNGIIHRDVKPANIM 145 Query: 198 LDKNYLAKLAGCGIAHC-SNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVYS 374 + K+ GIA ++ GN S T + T Y+ PE + A+SDVYS Sbjct: 146 ISATNAVKVMDFGIARAIADSGN----SVTQTAAVIGTAQYLSPEQARGDSVDARSDVYS 201 Query: 375 YGVLLLELVTGRPVVQDD 428 G +L E++TG P D Sbjct: 202 LGCVLYEVLTGEPPFTGD 219
>PKNB_BIFLO (Q8G6P9) Probable serine/threonine-protein kinase pknB (EC| 2.7.11.1) Length = 690 Score = 65.5 bits (158), Expect = 7e-11 Identities = 41/140 (29%), Positives = 73/140 (52%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVL 197 V E+++ +L+D + +G L ++ Q+ + V NAL+Y H + H DIKP N++ Sbjct: 99 VMEYVKGQTLRDIIKVNGAL--SQRDCEQVMLGVLNALDYSHRM---GIIHRDIKPGNIM 153 Query: 198 LDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVYSY 377 + + + K+ GIA + + + G V T Y+ PE + + +SD+YS Sbjct: 154 ISEQGVVKVMDFGIARALDDSAATMTQSQGVV---GTAQYLSPEQARGETVDMRSDLYSA 210 Query: 378 GVLLLELVTGRPVVQDDRSL 437 G +L E++TGRP D ++ Sbjct: 211 GCVLYEMLTGRPPFTGDSAV 230
>SRC64_DROME (P00528) Tyrosine-protein kinase Src64B (EC 2.7.10.2) (Dsrc64)| Length = 552 Score = 65.1 bits (157), Expect = 9e-11 Identities = 47/136 (34%), Positives = 68/136 (50%), Gaps = 7/136 (5%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVL 197 V E+M GSL D L L +++ I IA VA+ +EYL L H D+ NVL Sbjct: 355 VQEYMSKGSLLDFLREGDGRYLHFEDLIYIATQVASGMEYLE---SKQLIHRDLAARNVL 411 Query: 198 LDKNYLAKLAGCGIA-------HCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTA 356 + +N +AK+ G+A +C G+ VK A PE ++ + + Sbjct: 412 IGENNVAKICDFGLARVIADDEYCPKQGSRF------PVKWTA------PEAIIYGKFSI 459 Query: 357 KSDVYSYGVLLLELVT 404 KSDV+SYG+LL+EL T Sbjct: 460 KSDVWSYGILLMELFT 475
>PKN2_CORGL (Q8NU97) Serine/threonine protein kinases pknA (EC 2.7.11.1)| Length = 469 Score = 65.1 bits (157), Expect = 9e-11 Identities = 48/143 (33%), Positives = 68/143 (47%), Gaps = 1/143 (0%) Frame = +3 Query: 12 FQVYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSN 191 F V EF+ SL D L G+L P + + A+ L +H + H DIKP N Sbjct: 99 FIVMEFVRGESLADLLEREGRL--PEDLALDVMEQAAHGLSVIHRM---DMVHRDIKPGN 153 Query: 192 VLLDKNYLAKLAGCGIAHCSNGGN-TMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDV 368 +L+ N + K+ GIA + T G GT + YV PE +E+TA SD+ Sbjct: 154 MLITANGIVKITDFGIAKAAAAVPLTRTGMVVGTAQ------YVSPEQAQGKEVTAASDI 207 Query: 369 YSYGVLLLELVTGRPVVQDDRSL 437 YS GV+ E++ GR D S+ Sbjct: 208 YSLGVVGYEMMAGRRPFTGDSSV 230
>PKN1_THETN (Q8R9T6) Probable serine/threonine-protein kinase Sps1 (EC| 2.7.11.1) Length = 625 Score = 64.7 bits (156), Expect = 1e-10 Identities = 42/138 (30%), Positives = 69/138 (50%), Gaps = 1/138 (0%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVL 197 V E+++ +LK+ + +G L K ++IA V AL++ H + H DIKP N+L Sbjct: 86 VMEYVKGRTLKELIRENGGPL-EVKRAVEIASQVCRALDHAH---KNKIIHRDIKPQNIL 141 Query: 198 LDKNYLAKLAGCGIAHCSNGGN-TMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVYS 374 + + K+ GIA +NG T G GT Y PE + ++D+YS Sbjct: 142 VTDEDVVKVTDFGIARAANGATITYTGDVIGTAY------YFSPEQAKGSIVDERTDIYS 195 Query: 375 YGVLLLELVTGRPVVQDD 428 G++L E++TG+ + D Sbjct: 196 LGIVLFEMLTGKVPFEGD 213
>TESK2_RAT (Q924U5) Dual specificity testis-specific protein kinase 2 (EC| 2.7.12.1) (Testicular protein kinase 2) Length = 570 Score = 64.3 bits (155), Expect = 2e-10 Identities = 40/129 (31%), Positives = 72/129 (55%), Gaps = 3/129 (2%) Frame = +3 Query: 24 EFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVLL- 200 E++ +G+L+ L S+ L LPW R+++A D+A L YLHF ++H D+ N L+ Sbjct: 131 EYINSGNLEQLLDSN--LYLPWTVRVKLAYDIAVGLSYLHF---KGIFHRDLTSKNCLIK 185 Query: 201 --DKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVYS 374 + Y A +A G+A + +GS + + +P ++ PE + + K+DV+S Sbjct: 186 RDENGYSAVVADFGLA--EKIPDASIGSE--KLAVVGSPFWMAPEVLRDEPYNEKADVFS 241 Query: 375 YGVLLLELV 401 YG++L E++ Sbjct: 242 YGIILCEII 250
>ANKK1_HUMAN (Q8NFD2) Ankyrin repeat and protein kinase domain-containing| protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (X-kinase) (SgK288) Length = 765 Score = 63.2 bits (152), Expect = 3e-10 Identities = 43/131 (32%), Positives = 65/131 (49%), Gaps = 2/131 (1%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVL 197 V EFM NGSL+ L + L WK R +I + + A+ +LH PPL H D+KP N+L Sbjct: 97 VMEFMANGSLEKVLSTHS---LCWKLRFRIIHETSLAMNFLHSI-KPPLLHLDLKPGNIL 152 Query: 198 LDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELT--AKSDVY 371 LD N K++ G++ M ++ Y+ PE + K DVY Sbjct: 153 LDSNMHVKISDFGLSKWMEQSTRMQYIERSA--LRGMLSYIPPEMFLESNKAPGPKYDVY 210 Query: 372 SYGVLLLELVT 404 S+ +++ EL+T Sbjct: 211 SFAIVIWELLT 221
>PKN2_CLOPE (Q8XJL8) Probable serine/threonine protein kinase CPE1738 (EC| 2.7.11.1) Length = 685 Score = 62.8 bits (151), Expect = 4e-10 Identities = 44/131 (33%), Positives = 66/131 (50%), Gaps = 1/131 (0%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVL 197 V E++E +LKD + G L P++ I I I VA ALE H + H D+KP N+L Sbjct: 86 VMEYVEGKTLKDIIKEKGAL--PYEVAISIGIKVAKALECAH---KSGIIHRDVKPQNIL 140 Query: 198 LDKNYLAKLAGCGIAHCSNGGNTMVGSTPG-TVKIQATPGYVDPEYVVTQELTAKSDVYS 374 + + + K+ GIA +M ST T + + Y PE ++D+YS Sbjct: 141 VTEEGVVKVTDFGIA------KSMDSSTIAHTNSVMGSAHYFSPEQAKGTYTDYRTDLYS 194 Query: 375 YGVLLLELVTG 407 G++L E+VTG Sbjct: 195 LGIVLYEMVTG 205
>TESK2_HUMAN (Q96S53) Dual specificity testis-specific protein kinase 2 (EC| 2.7.12.1) (Testicular protein kinase 2) Length = 571 Score = 62.8 bits (151), Expect = 4e-10 Identities = 40/129 (31%), Positives = 72/129 (55%), Gaps = 3/129 (2%) Frame = +3 Query: 24 EFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVLL- 200 E++ +G+L+ L S+ L LPW R+++A D+A L YLHF ++H D+ N L+ Sbjct: 131 EYINSGNLEQLLDSN--LHLPWTVRVKLAYDIAVGLSYLHF---KGIFHRDLTSKNCLIK 185 Query: 201 --DKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVYS 374 + Y A +A G+A + +GS + + +P ++ PE + + K+DV+S Sbjct: 186 RDENGYSAVVADFGLA--EKIPDVSMGSE--KLAVVGSPFWMAPEVLRDEPYNEKADVFS 241 Query: 375 YGVLLLELV 401 YG++L E++ Sbjct: 242 YGIILCEII 250
>KYK1_DICDI (P18160) Non-receptor tyrosine kinase spore lysis A (EC 2.7.10.2)| (Tyrosine-protein kinase 1) Length = 1584 Score = 62.0 bits (149), Expect = 8e-10 Identities = 45/150 (30%), Positives = 71/150 (47%), Gaps = 14/150 (9%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLPWKN-RIQIAIDVANALEYLHFYCDPPLYHGDIKPSNV 194 V E+M GSL+ L LL + R+++A+D+A + YLH + PP+ H D+ N+ Sbjct: 1365 VTEWMGGGSLRQFLTDHFNLLEQNPHIRLKLALDIAKGMNYLHGWT-PPILHRDLSSRNI 1423 Query: 195 LLDKNY-------------LAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYV 335 LLD N K++ G++ + + + G + Y+ PE Sbjct: 1424 LLDHNIDPKNPVVSSRQDIKCKISDFGLSRLKKEQASQMTQSVGCIP------YMAPEVF 1477 Query: 336 VTQELTAKSDVYSYGVLLLELVTGRPVVQD 425 + KSDVYSYG++L EL+T QD Sbjct: 1478 KGDSNSEKSDVYSYGMVLFELLTSDEPQQD 1507
>TESK2_MOUSE (Q8VCT9) Dual specificity testis-specific protein kinase 2 (EC| 2.7.12.1) (Testicular protein kinase 2) Length = 570 Score = 62.0 bits (149), Expect = 8e-10 Identities = 39/129 (30%), Positives = 70/129 (54%), Gaps = 3/129 (2%) Frame = +3 Query: 24 EFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVLL- 200 E++ +G+L+ L S L LPW R+++A D+A L YLHF ++H D+ N L+ Sbjct: 131 EYINSGNLEQLLDSD--LYLPWTVRVKLAYDIAVGLSYLHF---KGIFHRDLTSKNCLIK 185 Query: 201 --DKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVYS 374 + Y A +A G+A + +G + + +P ++ PE + + K+DV+S Sbjct: 186 RDENGYSAVVADFGLA--EKIPDASIGRE--KLAVVGSPFWMAPEVLRDEPYNEKADVFS 241 Query: 375 YGVLLLELV 401 YG++L E++ Sbjct: 242 YGIILCEII 250
>GUC2G_RAT (P55205) Guanylate cyclase 2G precursor (EC 4.6.1.2) (Guanylyl| cyclase receptor G) (GC-G) (Kinase-like domain-containing soluble guanylyl cyclase) (ksGC) Length = 1100 Score = 61.6 bits (148), Expect = 1e-09 Identities = 41/132 (31%), Positives = 68/132 (51%), Gaps = 4/132 (3%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVL 197 V ++ + GSLKD L +S + W ++ D+ N + +LH P HG++KPSN L Sbjct: 631 VTQYCKKGSLKDVLRNSDHEM-DWIFKLSFVYDIVNGMLFLHG--SPLRSHGNLKPSNCL 687 Query: 198 LDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQEL----TAKSD 365 +D + KLAG G+ +G + + T + + PE + +EL T + D Sbjct: 688 VDSHMQLKLAGFGLWEFKHGSTCRIYNQEATDHSELY--WTAPELLRLRELPWSGTPQGD 745 Query: 366 VYSYGVLLLELV 401 VYS+ +LL +L+ Sbjct: 746 VYSFAILLRDLI 757
>RIPK2_MOUSE (P58801) Receptor-interacting serine/threonine-protein kinase 2 (EC| 2.7.11.1) Length = 539 Score = 61.2 bits (147), Expect = 1e-09 Identities = 43/134 (32%), Positives = 67/134 (50%), Gaps = 5/134 (3%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLL-LPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNV 194 V E+M NGSL + LH + + W R +I ++A + YLH +PPL H D+K N+ Sbjct: 94 VTEYMPNGSLNELLHRKTEYPDIAWPLRFRILHEIALGVNYLH-NMNPPLLHHDLKTQNI 152 Query: 195 LLDKNYLAKLAGCGIAH---CSNGGNTMVGSTP-GTVKIQATPGYVDPEYVVTQELTAKS 362 LLD + K+A G++ S + S P G I P +P + K Sbjct: 153 LLDNEFHVKIADFGLSKWRMMSLSQSRSYKSAPEGGTIIYMPPENYEPGQ--KSRASVKH 210 Query: 363 DVYSYGVLLLELVT 404 D+YSY V++ E+++ Sbjct: 211 DIYSYAVIMWEVLS 224
>PKN2_COREF (Q8FUI4) Serine/threonine protein kinases drp72 (EC 2.7.11.1)| Length = 520 Score = 61.2 bits (147), Expect = 1e-09 Identities = 47/143 (32%), Positives = 67/143 (46%), Gaps = 1/143 (0%) Frame = +3 Query: 12 FQVYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSN 191 F V E++ SL D L G L P + + + A+ L +H L H DIKP N Sbjct: 99 FIVLEYIRGESLADMLEREGAL--PEELALDVMEQAAHGLSVIHRM---GLVHRDIKPGN 153 Query: 192 VLLDKNYLAKLAGCGIAHCSNGGN-TMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDV 368 +L+ N + K+ GIA + T G GT + YV PE ++T SDV Sbjct: 154 MLITANGILKITDFGIAKAAASVPLTRTGMVVGTAQ------YVSPEQAQGHQVTPASDV 207 Query: 369 YSYGVLLLELVTGRPVVQDDRSL 437 YS GV+ E+++GR D S+ Sbjct: 208 YSLGVVGYEMLSGRRPFTGDSSV 230
>PKN5_MYXXA (P54737) Serine/threonine-protein kinase pkn5 (EC 2.7.11.1)| Length = 380 Score = 60.8 bits (146), Expect = 2e-09 Identities = 38/122 (31%), Positives = 67/122 (54%), Gaps = 2/122 (1%) Frame = +3 Query: 111 IDVANALEYLHFYCDPPLYHGDIKPSNVLLDKNYLAKLAGCGIAH--CSNGGNTMVGSTP 284 + + AL Y+H + L H D+KPSN+++D + +L G+A + T G Sbjct: 226 LQICEALAYIHGH---GLVHRDLKPSNIMVDDDRQVRLMDFGLAKFLADDAAITEAGKLV 282 Query: 285 GTVKIQATPGYVDPEYVVTQELTAKSDVYSYGVLLLELVTGRPVVQDDRSLVEWSRELIG 464 GT + Y+ PE ++ + L ++D+YS GV+L EL++GRP D ++ E R+++ Sbjct: 283 GTYR------YMAPEQILGEPLDGRADLYSLGVILYELLSGRPPF-DAKTPHELWRQVLE 335 Query: 465 TD 470 T+ Sbjct: 336 TE 337
>RIPK2_HUMAN (O43353) Receptor-interacting serine/threonine-protein kinase 2 (EC| 2.7.11.1) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (CARD-containing interleukin-1 beta-converting enzyme-associated kinase) (CARD-containi Length = 540 Score = 60.8 bits (146), Expect = 2e-09 Identities = 43/142 (30%), Positives = 69/142 (48%), Gaps = 6/142 (4%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLL-LPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNV 194 V E+M NGSL + LH + + W R +I ++A + YLH PPL H D+K N+ Sbjct: 94 VTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLH-NMTPPLLHHDLKTQNI 152 Query: 195 LLDKNYLAKLAGCGIA-----HCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAK 359 LLD + K+A G++ S ++ GT+ I P +P + K Sbjct: 153 LLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTI-IYMPPENYEPGQ--KSRASIK 209 Query: 360 SDVYSYGVLLLELVTGRPVVQD 425 D+YSY V+ E+++ + +D Sbjct: 210 HDIYSYAVITWEVLSRKQPFED 231
>PKN2_CLOAB (Q97IC2) Probable serine/threonine protein kinase CAC1728 (EC| 2.7.11.1) Length = 657 Score = 60.5 bits (145), Expect = 2e-09 Identities = 37/131 (28%), Positives = 65/131 (49%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVL 197 V E++ +LK + +GK+ + I A +A AL + H + H DIKP N++ Sbjct: 86 VMEYVAGKTLKKLIKENGKI--EFNKIIDYATQIAKALNFAH---KNGIVHRDIKPHNIM 140 Query: 198 LDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVYSY 377 + + + K+ GIA SN T K+ + Y+ PE + ++D+YS+ Sbjct: 141 VTDDDIIKVTDFGIAKASNESTITT-----TNKVVGSAHYLSPEQAQGIPVDCRTDIYSF 195 Query: 378 GVLLLELVTGR 410 G++L E+ TG+ Sbjct: 196 GIVLYEMATGK 206
>KAPA_YEAST (P06244) cAMP-dependent protein kinase type 1 (EC 2.7.11.11) (PKA| 1) (CDC25-suppressing protein kinase) (PK-25) Length = 397 Score = 60.5 bits (145), Expect = 2e-09 Identities = 44/150 (29%), Positives = 70/150 (46%), Gaps = 1/150 (0%) Frame = +3 Query: 12 FQVYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSN 191 F + +++E G L L S + P A +V ALEYLH + + D+KP N Sbjct: 161 FMIMDYIEGGELFSLLRKSQRFPNPVAKFY--AAEVCLALEYLH---SKDIIYRDLKPEN 215 Query: 192 VLLDKNYLAKLAGCGIA-HCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDV 368 +LLDKN K+ G A + + T+ G TP Y+ PE V T+ D Sbjct: 216 ILLDKNGHIKITDFGFAKYVPDVTYTLCG----------TPDYIAPEVVSTKPYNKSIDW 265 Query: 369 YSYGVLLLELVTGRPVVQDDRSLVEWSREL 458 +S+G+L+ E++ G D ++ + + L Sbjct: 266 WSFGILIYEMLAGYTPFYDSNTMKTYEKIL 295
>KKK1_YEAST (P34244) Probable serine/threonine-protein kinase YKL101W (EC| 2.7.11.1) Length = 1518 Score = 60.1 bits (144), Expect = 3e-09 Identities = 46/143 (32%), Positives = 68/143 (47%), Gaps = 2/143 (1%) Frame = +3 Query: 6 ERFQVYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKP 185 E + V E+++ G L D+L S GKL P + I + + Y H + + H D+KP Sbjct: 188 ELYLVLEYVDGGELFDYLVSKGKL--PEREAIHYFKQIVEGVSYCHSF---NICHRDLKP 242 Query: 186 SNVLLDK-NYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTA-K 359 N+LLDK N K+A G+A + S +P Y PE V+ + Sbjct: 243 ENLLLDKKNRRIKIADFGMAALELPNKLLKTSC-------GSPHYASPEIVMGRPYHGGP 295 Query: 360 SDVYSYGVLLLELVTGRPVVQDD 428 SDV+S G++L L+TG DD Sbjct: 296 SDVWSCGIVLFALLTGHLPFNDD 318
>KAPC_YEAST (P05986) cAMP-dependent protein kinase type 3 (EC 2.7.11.11) (PKA| 3) Length = 398 Score = 59.7 bits (143), Expect = 4e-09 Identities = 44/133 (33%), Positives = 64/133 (48%), Gaps = 1/133 (0%) Frame = +3 Query: 12 FQVYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSN 191 F V +++E G L L S + P A +V ALEYLH + + D+KP N Sbjct: 162 FMVMDYIEGGELFSLLRKSQRFPNPVAKFY--AAEVCLALEYLH---SKDIIYRDLKPEN 216 Query: 192 VLLDKNYLAKLAGCGIA-HCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDV 368 +LLDKN K+ G A + + T+ G TP Y+ PE V T+ D Sbjct: 217 ILLDKNGHIKITDFGFAKYVPDVTYTLCG----------TPDYIAPEVVSTKPYNKSVDW 266 Query: 369 YSYGVLLLELVTG 407 +S+GVL+ E++ G Sbjct: 267 WSFGVLIYEMLAG 279
>CSK_RAT (P32577) Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase)| Length = 450 Score = 59.7 bits (143), Expect = 4e-09 Identities = 40/127 (31%), Positives = 67/127 (52%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVL 197 V E+M GSL D+L S G+ +L ++ ++DV A+EYL H D+ NVL Sbjct: 265 VTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLE---GNNFVHRDLAARNVL 321 Query: 198 LDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVYSY 377 + ++ +AK++ G+ ST T K+ + PE + ++ + KSDV+S+ Sbjct: 322 VSEDNVAKVSDFGL-------TKEASSTQDTGKLPVK--WTAPEALREKKFSTKSDVWSF 372 Query: 378 GVLLLEL 398 G+LL E+ Sbjct: 373 GILLWEI 379
>CSK_HUMAN (P41240) Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase)| (Protein-tyrosine kinase CYL) Length = 450 Score = 59.7 bits (143), Expect = 4e-09 Identities = 40/127 (31%), Positives = 67/127 (52%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVL 197 V E+M GSL D+L S G+ +L ++ ++DV A+EYL H D+ NVL Sbjct: 265 VTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLE---GNNFVHRDLAARNVL 321 Query: 198 LDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVYSY 377 + ++ +AK++ G+ ST T K+ + PE + ++ + KSDV+S+ Sbjct: 322 VSEDNVAKVSDFGL-------TKEASSTQDTGKLPVK--WTAPEALREKKFSTKSDVWSF 372 Query: 378 GVLLLEL 398 G+LL E+ Sbjct: 373 GILLWEI 379
>CSK_CHICK (P41239) Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase)| Length = 450 Score = 59.7 bits (143), Expect = 4e-09 Identities = 40/127 (31%), Positives = 67/127 (52%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVL 197 V E+M GSL D+L S G+ +L ++ ++DV A+EYL H D+ NVL Sbjct: 265 VTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLE---ANNFVHRDLAARNVL 321 Query: 198 LDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVYSY 377 + ++ +AK++ G+ ST T K+ + PE + ++ + KSDV+S+ Sbjct: 322 VSEDNIAKVSDFGL-------TKEASSTQDTGKLPVK--WTAPEALREKKFSTKSDVWSF 372 Query: 378 GVLLLEL 398 G+LL E+ Sbjct: 373 GILLWEI 379
>GRK6_HUMAN (P43250) G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G| protein-coupled receptor kinase GRK6) Length = 576 Score = 59.3 bits (142), Expect = 5e-09 Identities = 41/142 (28%), Positives = 67/142 (47%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVL 197 V M G LK H++ G+ P + A ++ LE LH + + D+KP N+L Sbjct: 262 VLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLH---RERIVYRDLKPENIL 318 Query: 198 LDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVYSY 377 LD + +++ G+A G T+ G GTV GY+ PE V + T D ++ Sbjct: 319 LDDHGHIRISDLGLAVHVPEGQTIKGRV-GTV------GYMAPEVVKNERYTFSPDWWAL 371 Query: 378 GVLLLELVTGRPVVQDDRSLVE 443 G LL E++ G+ Q + ++ Sbjct: 372 GCLLYEMIAGQSPFQQRKKKIK 393
>CSK_MOUSE (P41241) Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase)| (Protein-tyrosine kinase MPK-2) (p50CSK) Length = 450 Score = 59.3 bits (142), Expect = 5e-09 Identities = 40/127 (31%), Positives = 67/127 (52%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVL 197 V E+M GSL D+L S G+ +L ++ ++DV A+EYL H D+ NVL Sbjct: 265 VTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVLEAMEYLE---GNNFVHRDLAARNVL 321 Query: 198 LDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVYSY 377 + ++ +AK++ G+ ST T K+ + PE + ++ + KSDV+S+ Sbjct: 322 VSEDNVAKVSDFGL-------TKEASSTQDTGKLPVK--WTAPEALREKKFSTKSDVWSF 372 Query: 378 GVLLLEL 398 G+LL E+ Sbjct: 373 GILLWEI 379
>PKN2_BACSU (O34507) Probable serine/threonine-protein kinase yloP (EC| 2.7.11.1) Length = 648 Score = 58.9 bits (141), Expect = 6e-09 Identities = 43/132 (32%), Positives = 68/132 (51%), Gaps = 1/132 (0%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVL 197 V E++E +LK+++ ++G L K + I + +A+ + H + H DIKP N+L Sbjct: 87 VMEYVEGMTLKEYITANGPLHP--KEALNIMEQIVSAIAHAH---QNQIVHRDIKPHNIL 141 Query: 198 LDKNYLAKLAGCGIAHC-SNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVYS 374 +D K+ GIA S+ T S G+V Y+ PE T KSD+Y+ Sbjct: 142 IDHMGNIKVTDFGIATALSSTTITHTNSVLGSVH------YLSPEQARGGLATKKSDIYA 195 Query: 375 YGVLLLELVTGR 410 G++L EL+TGR Sbjct: 196 LGIVLFELLTGR 207
>GRK6_MOUSE (O70293) G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G| protein-coupled receptor kinase GRK6) Length = 576 Score = 58.9 bits (141), Expect = 6e-09 Identities = 41/142 (28%), Positives = 67/142 (47%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVL 197 V M G LK H++ G+ P + A ++ LE LH + + D+KP N+L Sbjct: 262 VLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLH---RERIVYRDLKPENIL 318 Query: 198 LDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVYSY 377 LD + +++ G+A G T+ G GTV GY+ PE V + T D ++ Sbjct: 319 LDDHGHIRISDLGLAVHVPEGQTIKGRV-GTV------GYMAPEVVRNERYTFSPDWWAL 371 Query: 378 GVLLLELVTGRPVVQDDRSLVE 443 G LL E++ G+ Q + ++ Sbjct: 372 GCLLYEMIAGQSPFQQRKKKIK 393
>HT1_ARATH (Q2MHE4) Serine/threonine-protein kinase HT1 (EC 2.7.11.1) (High| leaf temperature protein 1) Length = 390 Score = 58.9 bits (141), Expect = 6e-09 Identities = 36/129 (27%), Positives = 65/129 (50%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVL 197 + E+M G+L+ +L+ L + +++A+D++ +EYLH + H D+K +N+L Sbjct: 163 ITEYMSQGNLRMYLNKKEPYSLSIETVLRLALDISRGMEYLH---SQGVIHRDLKSNNLL 219 Query: 198 LDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVYSY 377 L+ K+A G + G+ T ++ PE + + T K DVYS+ Sbjct: 220 LNDEMRVKVADFGTSCLETQCREAKGN-------MGTYRWMAPEMIKEKPYTRKVDVYSF 272 Query: 378 GVLLLELVT 404 G++L EL T Sbjct: 273 GIVLWELTT 281
>STK36_PONPY (Q5RAJ5) Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused| homolog) Length = 1315 Score = 58.5 bits (140), Expect = 8e-09 Identities = 45/125 (36%), Positives = 59/125 (47%) Frame = +3 Query: 39 GSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVLLDKNYLA 218 G L L GKL P IA + +AL YLH + + H D+KP N+LL K Sbjct: 85 GELLQILEDDGKL--PEDQVQAIAAQLVSALYYLHSH---RILHRDMKPQNILLAKGGGI 139 Query: 219 KLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVYSYGVLLLEL 398 KL G A + NTMV I+ TP Y+ PE V + +D++S G +L EL Sbjct: 140 KLCDFGFARAMST-NTMV-----LTSIKGTPLYMSPELVEERPYDHTADLWSVGCILYEL 193 Query: 399 VTGRP 413 G P Sbjct: 194 AVGTP 198
>PKNB_LACLA (Q9CEF5) Probable serine/threonine-protein kinase pknB (EC| 2.7.11.1) Length = 627 Score = 58.5 bits (140), Expect = 8e-09 Identities = 39/140 (27%), Positives = 70/140 (50%), Gaps = 5/140 (3%) Frame = +3 Query: 6 ERFQVYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKP 185 +++ V EF++ +LK +++ + L I+I ++ +A++ H + + H D+KP Sbjct: 85 QQYIVMEFVDGMTLKQYINQNAPLAND--EAIEIITEILSAMDMAHSH---GIIHRDLKP 139 Query: 186 SNVLLDKNYLAKLAGCGIAHCSNGG-----NTMVGSTPGTVKIQATPGYVDPEYVVTQEL 350 NVL+ + K+ GIA + NTM GS Y+ PE Sbjct: 140 QNVLVSSSGTVKVTDFGIAKALSETSLTQTNTMFGSVH----------YLSPEQARGSNA 189 Query: 351 TAKSDVYSYGVLLLELVTGR 410 T +SD+Y+ G++L EL+TG+ Sbjct: 190 TVQSDIYAIGIILFELLTGQ 209
>ICL1_KLULA (Q6CWQ4) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) Length = 361 Score = 58.2 bits (139), Expect = 1e-08 Identities = 45/152 (29%), Positives = 71/152 (46%), Gaps = 4/152 (2%) Frame = +3 Query: 15 QVYEFMEN-GSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSN 191 ++Y+F++N G L + L S +ANAL+Y+H + H DIKP N Sbjct: 184 ELYKFLKNNGPLNETLAS------------YFVYQMANALDYMH---SKNILHRDIKPEN 228 Query: 192 VLLDKNYLAKLAGCGIAHCSNGGN---TMVGSTPGTVKIQATPGYVDPEYVVTQELTAKS 362 +L+ N KL G + + G T+ G T Y+ PE + ++E K Sbjct: 229 ILIGFNNTIKLTDFGWSVYNEDGQKRKTLCG----------TIDYLSPELIKSREYNNKV 278 Query: 363 DVYSYGVLLLELVTGRPVVQDDRSLVEWSREL 458 DV++ GVL EL+ G P ++D + + R L Sbjct: 279 DVWALGVLTYELLVGSPPFEEDTKEMTYRRIL 310
>PKNL_MYCTU (O53510) Probable serine/threonine-protein kinase pknL (EC| 2.7.11.1) Length = 399 Score = 58.2 bits (139), Expect = 1e-08 Identities = 45/142 (31%), Positives = 62/142 (43%) Frame = +3 Query: 12 FQVYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSN 191 F V E +E G+L++ L G + P + + V L H L H D+KP N Sbjct: 93 FLVMELIEGGTLRELLIERGPM--PPHAVVAVLRPVLGGLAAAH---RAGLVHRDVKPEN 147 Query: 192 VLLDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVY 371 +L+ + KLA G+ S T I T Y+ PE V +SDVY Sbjct: 148 ILISDDGDVKLADFGLVRA-----VAAASITSTGVILGTAAYLSPEQVRDGNADPRSDVY 202 Query: 372 SYGVLLLELVTGRPVVQDDRSL 437 S GVL+ EL+TG D +L Sbjct: 203 SVGVLVYELLTGHTPFTGDSAL 224
>PKNL_MYCBO (Q7TYY6) Probable serine/threonine-protein kinase pknL (EC| 2.7.11.1) Length = 399 Score = 58.2 bits (139), Expect = 1e-08 Identities = 45/142 (31%), Positives = 62/142 (43%) Frame = +3 Query: 12 FQVYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSN 191 F V E +E G+L++ L G + P + + V L H L H D+KP N Sbjct: 93 FLVMELIEGGTLRELLIERGPM--PPHAVVAVLRPVLGGLAAAH---RAGLVHRDVKPEN 147 Query: 192 VLLDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVY 371 +L+ + KLA G+ S T I T Y+ PE V +SDVY Sbjct: 148 ILISDDGDVKLADFGLVRA-----VAAASITSTGVILGTAAYLSPEQVRDGNADPRSDVY 202 Query: 372 SYGVLLLELVTGRPVVQDDRSL 437 S GVL+ EL+TG D +L Sbjct: 203 SVGVLVYELLTGHTPFTGDSAL 224
>STK36_HUMAN (Q9NRP7) Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused| homolog) Length = 1315 Score = 58.2 bits (139), Expect = 1e-08 Identities = 45/125 (36%), Positives = 59/125 (47%) Frame = +3 Query: 39 GSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVLLDKNYLA 218 G L L GKL P IA + +AL YLH + + H D+KP N+LL K Sbjct: 85 GELFQILEDDGKL--PEDQVQAIAAQLVSALYYLHSH---RILHRDMKPQNILLAKGGGI 139 Query: 219 KLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVYSYGVLLLEL 398 KL G A + NTMV I+ TP Y+ PE V + +D++S G +L EL Sbjct: 140 KLCDFGFARAMST-NTMV-----LTSIKGTPLYMSPELVEERPYDHTADLWSVGCILYEL 193 Query: 399 VTGRP 413 G P Sbjct: 194 AVGTP 198
>CHK1_YEAST (P38147) Serine/threonine-protein kinase CHK1 (EC 2.7.11.1)| (Checkpoint kinase 1) Length = 527 Score = 58.2 bits (139), Expect = 1e-08 Identities = 36/104 (34%), Positives = 59/104 (56%), Gaps = 6/104 (5%) Frame = +3 Query: 117 VANALEYLHFYCDPPLYHGDIKPSNVLLDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVK 296 + +A+ YLH C + H DIKP N+LLDKN KLA G+A + GT++ Sbjct: 125 LVSAINYLHVECG--VAHRDIKPENILLDKNGNLKLADFGLA-------SQFRRKDGTLR 175 Query: 297 I----QATPGYVDPEYVVTQE--LTAKSDVYSYGVLLLELVTGR 410 + + +P Y+ PE + ++E ++D++S G+LL L+TG+ Sbjct: 176 VSMDQRGSPPYMAPEVLYSEEGYYADRTDIWSIGILLFVLLTGQ 219
>NEK4_MOUSE (Q9Z1J2) Serine/threonine-protein kinase Nek4 (EC 2.7.11.1)| (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) Length = 792 Score = 58.2 bits (139), Expect = 1e-08 Identities = 39/129 (30%), Positives = 57/129 (44%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVL 197 V F E G L L LLP ++ + +A AL+YLH + + H D+K NV Sbjct: 82 VMGFCEGGDLYRKLKEQKGQLLPESQVVEWFVQIAMALQYLH---EKHILHRDLKTQNVF 138 Query: 198 LDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVYSY 377 L + + K+ GIA M + G TP Y+ PE + KSDV++ Sbjct: 139 LTRTNIIKVGDLGIARVLENHGDMASTLIG------TPYYMSPELFSNKPYNYKSDVWAL 192 Query: 378 GVLLLELVT 404 G + E+ T Sbjct: 193 GCCVYEMAT 201
>STK36_MOUSE (Q69ZM6) Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused| homolog) Length = 1268 Score = 58.2 bits (139), Expect = 1e-08 Identities = 45/125 (36%), Positives = 59/125 (47%) Frame = +3 Query: 39 GSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVLLDKNYLA 218 G L L GKL P IA + +AL YLH + + H D+KP N+LL K Sbjct: 85 GELFQILEDDGKL--PEDQVQAIAAQLVSALYYLHSH---RILHRDMKPQNILLAKGGGI 139 Query: 219 KLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVYSYGVLLLEL 398 KL G A + NTMV I+ TP Y+ PE V + +D++S G +L EL Sbjct: 140 KLCDFGFARAMST-NTMV-----LTSIKGTPLYMSPELVEERPYDHTADLWSVGCILYEL 193 Query: 399 VTGRP 413 G P Sbjct: 194 AVGTP 198
>ULK2_MOUSE (Q9QY01) Serine/threonine-protein kinase ULK2 (EC 2.7.11.1)| (Unc-51-like kinase 2) (Serine/threonine-protein kinase Unc51.2) Length = 1037 Score = 57.8 bits (138), Expect = 1e-08 Identities = 43/158 (27%), Positives = 76/158 (48%), Gaps = 8/158 (5%) Frame = +3 Query: 12 FQVYEFMENGSLKDHLHSSGKLLLPWKNRIQIAI-DVANALEYLHFYCDPPLYHGDIKPS 188 F V E+ G L D+L + G L ++ I++ + +A A+ LH + H D+KP Sbjct: 82 FLVMEYCNGGDLADYLQAKGTLS---EDTIRVFLHQIAAAMRILH---SKGIIHRDLKPQ 135 Query: 189 NVLLD--KNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKS 362 N+LL + ++G I G + S + +P Y+ PE +++Q AK+ Sbjct: 136 NILLSYANRRKSNVSGIRIKIADFGFARYLHSNTMAATLCGSPMYMAPEVIMSQHYDAKA 195 Query: 363 DVYSYGVLLLELVTGRPVV-----QDDRSLVEWSRELI 461 D++S G ++ + + G+P QD R E +R L+ Sbjct: 196 DLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKNRSLM 233
>PKN6_MYXXA (P54738) Serine/threonine-protein kinase pkn6 (EC 2.7.11.1)| Length = 710 Score = 57.8 bits (138), Expect = 1e-08 Identities = 39/140 (27%), Positives = 66/140 (47%), Gaps = 7/140 (5%) Frame = +3 Query: 12 FQVYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPP------LYHG 173 F EF++ +L+ + + + LP ++ A L Y H + D L H Sbjct: 83 FLAMEFIDGPNLRKLVKRAAEEALPPAFCAKVVAAAAEGLAYAHEFRDVETGEPLGLIHR 142 Query: 174 DIKPSNVLLDKNYLAKLAGCGIAHCSNGGN-TMVGSTPGTVKIQATPGYVDPEYVVTQEL 350 D+ P N+L+ + K+ GIA + G+ T+ G G V Y+ PE + + + Sbjct: 143 DVSPDNILVSRQGAVKVVDFGIAKVAGQGHRTLTGVVKGKV------AYMPPEQLQAKAM 196 Query: 351 TAKSDVYSYGVLLLELVTGR 410 + DVY+ GV+L EL+TG+ Sbjct: 197 DRRVDVYALGVVLYELLTGK 216
>GRK6_RAT (P97711) G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G| protein-coupled receptor kinase GRK6) Length = 576 Score = 57.8 bits (138), Expect = 1e-08 Identities = 40/142 (28%), Positives = 66/142 (46%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVL 197 V M G LK H++ G+ P + A ++ LE LH + + D+KP N+L Sbjct: 262 VLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLH---RERIVYRDLKPENIL 318 Query: 198 LDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVYSY 377 LD + +++ G+ G T+ G GTV GY+ PE V + T D ++ Sbjct: 319 LDDHGHIRISDLGLTVHVPEGQTIKGRV-GTV------GYMAPEVVKNERYTFSPDWWAL 371 Query: 378 GVLLLELVTGRPVVQDDRSLVE 443 G LL E++ G+ Q + ++ Sbjct: 372 GCLLYEMIAGQSPFQQRKKKIK 393
>CLA4_YEAST (P48562) Serine/threonine-protein kinase CLA4 (EC 2.7.11.1)| Length = 842 Score = 57.8 bits (138), Expect = 1e-08 Identities = 45/139 (32%), Positives = 62/139 (44%), Gaps = 7/139 (5%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSS-------GKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGD 176 V EFME GSL D + +S L P QIA V + L F D + H D Sbjct: 639 VMEFMEGGSLTDIIENSPTNDNSHSPLTEP-----QIAYIVRETCQGLKFLHDKHIIHRD 693 Query: 177 IKPSNVLLDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTA 356 IK NVLLD K+ G C+ + + TP ++ PE V +E Sbjct: 694 IKSDNVLLDTRARVKITDFGF--CAR----LTDKRSKRATMVGTPYWMAPEVVKQREYDE 747 Query: 357 KSDVYSYGVLLLELVTGRP 413 K DV+S G++ +E++ G P Sbjct: 748 KIDVWSLGIMTIEMLEGEP 766
>MATK_MOUSE (P41242) Megakaryocyte-associated tyrosine-protein kinase (EC| 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK) Length = 505 Score = 57.8 bits (138), Expect = 1e-08 Identities = 40/127 (31%), Positives = 66/127 (51%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVL 197 V E + G+L + L + G+ L+ +Q A+ VA +EYL L H D+ N+L Sbjct: 301 VMEHVSKGNLVNFLRTRGRALVSTSQLLQFALHVAEGMEYLE---SKKLVHRDLAARNIL 357 Query: 198 LDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVYSY 377 + ++ +AK++ G+A G + S+ VK A PE + ++KSDV+S+ Sbjct: 358 VSEDLVAKVSDFGLAKAERKG---LDSSRLPVKWTA------PEALKNGRFSSKSDVWSF 408 Query: 378 GVLLLEL 398 GVLL E+ Sbjct: 409 GVLLWEV 415
>KAPB_YEAST (P06245) cAMP-dependent protein kinase type 2 (EC 2.7.11.11) (PKA| 2) Length = 380 Score = 57.4 bits (137), Expect = 2e-08 Identities = 45/151 (29%), Positives = 69/151 (45%) Frame = +3 Query: 12 FQVYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSN 191 F V +++E G L L S + P A +V ALEYLH + + + D+KP N Sbjct: 144 FMVMDYIEGGELFSLLRKSQRFPNPVAKFY--AAEVILALEYLHAH---NIIYRDLKPEN 198 Query: 192 VLLDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVY 371 +LLD+N K+ G A T+ + GT P Y+ PE + T+ D + Sbjct: 199 ILLDRNGHIKITDFGFA---KEVQTVTWTLCGT------PDYIAPEVITTKPYNKSVDWW 249 Query: 372 SYGVLLLELVTGRPVVQDDRSLVEWSRELIG 464 S GVL+ E++ G D + + + L G Sbjct: 250 SLGVLIYEMLAGYTPFYDTTPMKTYEKILQG 280
>FUSED_DROME (P23647) Serine/threonine-protein kinase fused (EC 2.7.11.1)| Length = 805 Score = 57.4 bits (137), Expect = 2e-08 Identities = 36/99 (36%), Positives = 50/99 (50%) Frame = +3 Query: 117 VANALEYLHFYCDPPLYHGDIKPSNVLLDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVK 296 + +AL YLH + H D+KP NVLLDKN AKL G+A M T Sbjct: 109 LVSALYYLH---SNRILHRDLKPQNVLLDKNMHAKLCDFGLA------RNMTLGTHVLTS 159 Query: 297 IQATPGYVDPEYVVTQELTAKSDVYSYGVLLLELVTGRP 413 I+ TP Y+ PE + Q +D++S G + E + G+P Sbjct: 160 IKGTPLYMAPELLAEQPYDHHADMWSLGCIAYESMAGQP 198
>KSS1_YEAST (P14681) Mitogen-activated protein kinase KSS1 (EC 2.7.11.24) (MAP| kinase KSS1) (Kinase suppressor of SST2) Length = 368 Score = 57.4 bits (137), Expect = 2e-08 Identities = 39/105 (37%), Positives = 58/105 (55%), Gaps = 5/105 (4%) Frame = +3 Query: 117 VANALEYLHFYCDPPLYHGDIKPSNVLLDKNYLAKLAGCGIAHC----SNGGNTMVGSTP 284 + AL+ +H + H DIKPSN+LL+ N K+ G+A C S+ T+VG Sbjct: 127 ILRALKSIH---SAQVIHRDIKPSNLLLNSNCDLKVCDFGLARCLASSSDSRETLVGFMT 183 Query: 285 GTVKIQATPGYVDPEYVVT-QELTAKSDVYSYGVLLLELVTGRPV 416 V AT Y PE ++T QE T D++S G +L E+V+G+P+ Sbjct: 184 EYV---ATRWYRAPEIMLTFQEYTTAMDIWSCGCILAEMVSGKPL 225
>NEK4_HUMAN (P51957) Serine/threonine-protein kinase Nek4 (EC 2.7.11.1)| (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2) Length = 841 Score = 57.4 bits (137), Expect = 2e-08 Identities = 41/134 (30%), Positives = 61/134 (45%), Gaps = 5/134 (3%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVL 197 V F E G L L LLP ++ + +A AL+YLH + + H D+K NV Sbjct: 82 VMGFCEGGDLYRKLKEQKGQLLPENQVVEWFVQIAMALQYLH---EKHILHRDLKTQNVF 138 Query: 198 LDKNYLAKLAGCGIA-----HCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKS 362 L + + K+ GIA HC +T++G TP Y+ PE + KS Sbjct: 139 LTRTNIIKVGDLGIARVLENHCDMA-STLIG----------TPYYMSPELFSNKPYNYKS 187 Query: 363 DVYSYGVLLLELVT 404 DV++ G + E+ T Sbjct: 188 DVWALGCCVYEMAT 201
>PKN1_COREF (Q8FUI5) Probable serine/threonine protein kinase CE0033 (EC| 2.7.11.1) Length = 660 Score = 57.4 bits (137), Expect = 2e-08 Identities = 34/103 (33%), Positives = 54/103 (52%) Frame = +3 Query: 105 IAIDVANALEYLHFYCDPPLYHGDIKPSNVLLDKNYLAKLAGCGIAHCSNGGNTMVGSTP 284 I I V +AL+ H + + H D+KP+N++++ K+ GIA + + + T Sbjct: 116 IMIPVCHALQSSH---EAGIIHRDVKPANIMINNTGGVKVMDFGIARALDDSTSAMTQTA 172 Query: 285 GTVKIQATPGYVDPEYVVTQELTAKSDVYSYGVLLLELVTGRP 413 + T Y+ PE + A+SDVY+ G +L ELVTGRP Sbjct: 173 AVI---GTAQYLSPEQARGKPADARSDVYAAGCVLYELVTGRP 212
>PKN1_CORGL (Q8NU98) Probable serine/threonine protein kinase pknB (EC| 2.7.11.1) Length = 646 Score = 57.4 bits (137), Expect = 2e-08 Identities = 33/103 (32%), Positives = 52/103 (50%) Frame = +3 Query: 105 IAIDVANALEYLHFYCDPPLYHGDIKPSNVLLDKNYLAKLAGCGIAHCSNGGNTMVGSTP 284 I I V AL+ H D + H D+KP+N+++ K+ GIA N + + T Sbjct: 116 ILIPVCEALQASH---DAGIIHRDVKPANIMITNTGGVKVMDFGIARAVNDSTSAMTQTS 172 Query: 285 GTVKIQATPGYVDPEYVVTQELTAKSDVYSYGVLLLELVTGRP 413 + T Y+ PE + A+SD+Y+ G ++ ELVTG+P Sbjct: 173 AVI---GTAQYLSPEQARGKPADARSDIYATGCVMYELVTGKP 212
>ULK2_HUMAN (Q8IYT8) Serine/threonine-protein kinase ULK2 (EC 2.7.11.1)| (Unc-51-like kinase 2) Length = 1036 Score = 57.4 bits (137), Expect = 2e-08 Identities = 43/158 (27%), Positives = 76/158 (48%), Gaps = 8/158 (5%) Frame = +3 Query: 12 FQVYEFMENGSLKDHLHSSGKLLLPWKNRIQIAI-DVANALEYLHFYCDPPLYHGDIKPS 188 F V E+ G L D+L + G L ++ I++ + +A A+ LH + H D+KP Sbjct: 82 FLVMEYCNGGDLADYLQAKGTLS---EDTIRVFLHQIAAAMRILH---SKGIIHRDLKPQ 135 Query: 189 NVLLD--KNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKS 362 N+LL + ++G I G + S + +P Y+ PE +++Q AK+ Sbjct: 136 NILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAATLCGSPMYMAPEVIMSQHYDAKA 195 Query: 363 DVYSYGVLLLELVTGRPVV-----QDDRSLVEWSRELI 461 D++S G ++ + + G+P QD R E +R L+ Sbjct: 196 DLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKNRSLM 233
>AAPK1_PONPY (Q5RDH5) 5'-AMP-activated protein kinase catalytic subunit alpha-1| (EC 2.7.11.1) (AMPK alpha-1 chain) Length = 550 Score = 57.0 bits (136), Expect = 2e-08 Identities = 42/141 (29%), Positives = 72/141 (51%), Gaps = 2/141 (1%) Frame = +3 Query: 12 FQVYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSN 191 F V E++ G L D++ +G+L K ++ + + ++Y H + + H D+KP N Sbjct: 92 FMVMEYVSGGELFDYICKNGRL--DEKESRRLFQQILSGVDYCHRHM---VVHRDLKPEN 146 Query: 192 VLLDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTA--KSD 365 VLLD + AK+A G+++ + G + S +P Y PE V++ L A + D Sbjct: 147 VLLDAHMNAKIADFGLSNMMSDGEFLRTSC-------GSPNYAAPE-VISGRLYAGPEVD 198 Query: 366 VYSYGVLLLELVTGRPVVQDD 428 ++S GV+L L+ G DD Sbjct: 199 IWSSGVILYALLCGTLPFDDD 219
>AAPK1_HUMAN (Q13131) 5'-AMP-activated protein kinase catalytic subunit alpha-1| (EC 2.7.11.1) (AMPK alpha-1 chain) Length = 550 Score = 57.0 bits (136), Expect = 2e-08 Identities = 42/141 (29%), Positives = 72/141 (51%), Gaps = 2/141 (1%) Frame = +3 Query: 12 FQVYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSN 191 F V E++ G L D++ +G+L K ++ + + ++Y H + + H D+KP N Sbjct: 92 FMVMEYVSGGELFDYICKNGRL--DEKESRRLFQQILSGVDYCHRHM---VVHRDLKPEN 146 Query: 192 VLLDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTA--KSD 365 VLLD + AK+A G+++ + G + S +P Y PE V++ L A + D Sbjct: 147 VLLDAHMNAKIADFGLSNMMSDGEFLRTSC-------GSPNYAAPE-VISGRLYAGPEVD 198 Query: 366 VYSYGVLLLELVTGRPVVQDD 428 ++S GV+L L+ G DD Sbjct: 199 IWSSGVILYALLCGTLPFDDD 219
>AAPK1_RAT (P54645) 5'-AMP-activated protein kinase catalytic subunit alpha-1| (EC 2.7.11.1) (AMPK alpha-1 chain) Length = 548 Score = 57.0 bits (136), Expect = 2e-08 Identities = 42/141 (29%), Positives = 72/141 (51%), Gaps = 2/141 (1%) Frame = +3 Query: 12 FQVYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSN 191 F V E++ G L D++ +G+L K ++ + + ++Y H + + H D+KP N Sbjct: 90 FMVMEYVSGGELFDYICKNGRL--DEKESRRLFQQILSGVDYCHRHM---VVHRDLKPEN 144 Query: 192 VLLDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTA--KSD 365 VLLD + AK+A G+++ + G + S +P Y PE V++ L A + D Sbjct: 145 VLLDAHMNAKIADFGLSNMMSDGEFLRTSC-------GSPNYAAPE-VISGRLYAGPEVD 196 Query: 366 VYSYGVLLLELVTGRPVVQDD 428 ++S GV+L L+ G DD Sbjct: 197 IWSSGVILYALLCGTLPFDDD 217
>AAPK1_MOUSE (Q5EG47) 5'-AMP-activated protein kinase catalytic subunit alpha-1| (EC 2.7.11.1) (AMPK alpha-1 chain) Length = 548 Score = 57.0 bits (136), Expect = 2e-08 Identities = 42/141 (29%), Positives = 72/141 (51%), Gaps = 2/141 (1%) Frame = +3 Query: 12 FQVYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSN 191 F V E++ G L D++ +G+L K ++ + + ++Y H + + H D+KP N Sbjct: 90 FMVMEYVSGGELFDYICKNGRL--DEKESRRLFQQILSGVDYCHRHM---VVHRDLKPEN 144 Query: 192 VLLDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTA--KSD 365 VLLD + AK+A G+++ + G + S +P Y PE V++ L A + D Sbjct: 145 VLLDAHMNAKIADFGLSNMMSDGEFLRTSC-------GSPNYAAPE-VISGRLYAGPEVD 196 Query: 366 VYSYGVLLLELVTGRPVVQDD 428 ++S GV+L L+ G DD Sbjct: 197 IWSSGVILYALLCGTLPFDDD 217
>MATK_HUMAN (P42679) Megakaryocyte-associated tyrosine-protein kinase (EC| 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase) Length = 507 Score = 57.0 bits (136), Expect = 2e-08 Identities = 40/127 (31%), Positives = 67/127 (52%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVL 197 V E + G+L + L + G+ L+ +Q ++ VA +EYL L H D+ N+L Sbjct: 303 VMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLE---SKKLVHRDLAARNIL 359 Query: 198 LDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVYSY 377 + ++ +AK++ G+A G + S+ VK A PE + + T+KSDV+S+ Sbjct: 360 VSEDLVAKVSDFGLAKAERKG---LDSSRLPVKWTA------PEALKHGKFTSKSDVWSF 410 Query: 378 GVLLLEL 398 GVLL E+ Sbjct: 411 GVLLWEV 417
>KGS9_YEAST (P43637) Probable serine/threonine-protein kinase YGL179C (EC| 2.7.11.1) Length = 560 Score = 56.6 bits (135), Expect = 3e-08 Identities = 36/127 (28%), Positives = 67/127 (52%), Gaps = 6/127 (4%) Frame = +3 Query: 48 KDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVLLDKNYLAKLA 227 K + + G +L ++ ++ +DV + LEYLH + H DIKPSN+L+ N K++ Sbjct: 150 KMEIKAVGPSILTFQQSRKVVLDVVSGLEYLH---SQGITHRDIKPSNLLISSNGTVKIS 206 Query: 228 GCGIAHCSNGGNTMVGSTPGTV---KIQATPGYVDPEYVVTQE---LTAKSDVYSYGVLL 389 G+A + G+T + S+ + + TP + PE T++ ++ D++S GV + Sbjct: 207 DFGVAMSTATGSTNIQSSHEQLLKSRALGTPAFFAPELCSTEKEYSCSSAIDIWSLGVTI 266 Query: 390 LELVTGR 410 L+ G+ Sbjct: 267 YCLLFGK 273
>FRK_HUMAN (P42685) Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear| tyrosine protein kinase RAK) Length = 505 Score = 56.6 bits (135), Expect = 3e-08 Identities = 34/129 (26%), Positives = 67/129 (51%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVL 197 + E M +GSL+++L + + ++ +A VA+ + YL H D+ NVL Sbjct: 305 ITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAYLE---SRNYIHRDLAARNVL 361 Query: 198 LDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVYSY 377 + ++ + K+A G+A N + + +K+ + PE + + + + KSDV+S+ Sbjct: 362 VGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVK--WTAPEAIRSNKFSIKSDVWSF 419 Query: 378 GVLLLELVT 404 G+LL E++T Sbjct: 420 GILLYEIIT 428
>M3K7_DROME (Q9V3Q6) Mitogen-activated protein kinase kinase kinase 7 (EC| 2.7.11.25) (TGF-beta-activated kinase 1) (dTAK1) Length = 678 Score = 56.6 bits (135), Expect = 3e-08 Identities = 38/147 (25%), Positives = 66/147 (44%), Gaps = 2/147 (1%) Frame = +3 Query: 12 FQVYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSN 191 + + EF E GSL + LH K + + A A L YLH PL H D+KP N Sbjct: 86 YLIMEFAEGGSLHNFLHGKVKPAYSLAHAMSWARQCAEGLAYLHAMTPKPLIHRDVKPLN 145 Query: 192 VLLDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVY 371 +LL G + C G T+ + + + ++ PE + T K D++ Sbjct: 146 LLLTNK------GRNLKICDFG--TVADKSTMMTNNRGSAAWMAPEVFEGSKYTEKCDIF 197 Query: 372 SYGVLLLELVTGRPVVQ--DDRSLVEW 446 S+ ++L E+++ + + D+ ++W Sbjct: 198 SWAIVLWEVLSRKQPFKGIDNAYTIQW 224
>CLA4_ASHGO (Q9HFW2) Serine/threonine-protein kinase CLA4 (EC 2.7.11.1)| Length = 793 Score = 56.6 bits (135), Expect = 3e-08 Identities = 43/142 (30%), Positives = 64/142 (45%), Gaps = 2/142 (1%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSS--GKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSN 191 V E+ME GSL D + +S QIA V + L F D + H DIK N Sbjct: 590 VMEYMEGGSLTDVIENSIGSDASESPMTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDN 649 Query: 192 VLLDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVY 371 VLLD + K+ G C+ + + TP ++ PE V +E K DV+ Sbjct: 650 VLLDTHGRVKITDFGF--CAK----LTDKRSKRATMVGTPYWMAPEVVKQREYDEKVDVW 703 Query: 372 SYGVLLLELVTGRPVVQDDRSL 437 S G++ +E++ G P ++ L Sbjct: 704 SLGIMTIEMLEGEPPYLNEEPL 725
>ANKK1_MOUSE (Q8BZ25) Ankyrin repeat and protein kinase domain-containing| protein 1 (EC 2.7.11.1) Length = 745 Score = 56.6 bits (135), Expect = 3e-08 Identities = 41/135 (30%), Positives = 68/135 (50%), Gaps = 6/135 (4%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVL 197 V EFM +GSL+ L + L W +++I + + A+ +LH PPL H D+KP N+L Sbjct: 109 VMEFMASGSLEKTLPTHS---LCWPLKLRIIHETSLAMNFLHSI-KPPLLHLDLKPGNIL 164 Query: 198 LDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTV----KIQATPGYVDPEYVVTQELT--AK 359 LD N K++ G++ M ST ++ T Y+ PE + + Sbjct: 165 LDNNMHVKISDFGLS------KWMEQSTQKQYIERSALRGTLSYIPPEMFLENNKAPGPE 218 Query: 360 SDVYSYGVLLLELVT 404 DVYS+ +++ E++T Sbjct: 219 YDVYSFAIVIWEILT 233
>ARK1_SCHPO (O59790) Serine/threonine-protein kinase ark1 (EC 2.7.11.1)| (Aurora-related kinase 1) Length = 355 Score = 56.2 bits (134), Expect = 4e-08 Identities = 45/140 (32%), Positives = 64/140 (45%), Gaps = 2/140 (1%) Frame = +3 Query: 12 FQVYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSN 191 + + EF G L HL + + ++ +ANAL YLH + H DIKP N Sbjct: 163 YLILEFAGRGELYQHLRRAKRFSEEVASKY--IFQMANALSYLH---KKHVIHRDIKPEN 217 Query: 192 VLLDKNYLAKLA--GCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSD 365 +LL + KL+ G + SN T+ G T Y+ PE V +E T K D Sbjct: 218 ILLGIDGEIKLSDFGWSVHAPSNRRTTLCG----------TLDYLPPEMVEGKEHTEKVD 267 Query: 366 VYSYGVLLLELVTGRPVVQD 425 ++S GVL E + G P +D Sbjct: 268 LWSLGVLTYEFLVGAPPFED 287
>PK2_DICDI (P28178) Protein kinase 2 (EC 2.7.11.1)| Length = 479 Score = 56.2 bits (134), Expect = 4e-08 Identities = 40/135 (29%), Positives = 65/135 (48%), Gaps = 1/135 (0%) Frame = +3 Query: 12 FQVYEFMENGSLKDHLHSSGKLLLPWKNRIQI-AIDVANALEYLHFYCDPPLYHGDIKPS 188 + V +F+ G L HL G+ P R++I A ++ +AL++LH + + D+KP Sbjct: 227 YMVLDFVNGGELFFHLKREGRFSEP---RVKIYAAEIVSALDHLH---KQDIVYRDLKPE 280 Query: 189 NVLLDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDV 368 N+LLD + G++ + +T GT TP Y+ PE + D Sbjct: 281 NILLDSEGHICITDFGLSK-------KIETTDGTFTFCGTPEYLAPEVLNGHGHGCAVDW 333 Query: 369 YSYGVLLLELVTGRP 413 +S G LL E++TG P Sbjct: 334 WSLGTLLYEMLTGLP 348
>RIPK1_MOUSE (Q60855) Receptor-interacting serine/threonine-protein kinase 1 (EC| 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein) Length = 656 Score = 55.8 bits (133), Expect = 5e-08 Identities = 38/134 (28%), Positives = 66/134 (49%), Gaps = 10/134 (7%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVL 197 V E+ME G+L L + + L K RI + A+E + + D + H D+KP N+L Sbjct: 91 VMEYMEKGNLMHVLKTQIDVPLSLKGRI-----IVEAIEGMCYLHDKGVIHKDLKPENIL 145 Query: 198 LDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPG--------YVDPEYV--VTQE 347 +D+++ K+A G+A ++ +T Y+ PE++ + + Sbjct: 146 VDRDFHIKIADLGVASFKTWSKLTKEKDNKQKEVSSTTKKNNGGTLYYMAPEHLNDINAK 205 Query: 348 LTAKSDVYSYGVLL 389 T KSDVYS+G++L Sbjct: 206 PTEKSDVYSFGIVL 219
>ABL1_CAEEL (P03949) Tyrosine-protein kinase abl-1 (EC 2.7.10.2)| Length = 1224 Score = 55.8 bits (133), Expect = 5e-08 Identities = 41/132 (31%), Positives = 67/132 (50%), Gaps = 3/132 (2%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYL---HFYCDPPLYHGDIKPS 188 + EFM NG+L ++L + K LLP +Q+A +A+ + YL HF H D+ Sbjct: 383 ITEFMCNGNLLEYLRRTDKSLLPPIILVQMASQIASGMSYLEARHF------IHRDLAAR 436 Query: 189 NVLLDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDV 368 N L+ ++ + K+A G+A +T I+ T PE + ++KSDV Sbjct: 437 NCLVSEHNIVKIADFGLARFMK-EDTYTAHAGAKFPIKWTA----PEGLAFNTFSSKSDV 491 Query: 369 YSYGVLLLELVT 404 +++GVLL E+ T Sbjct: 492 WAFGVLLWEIAT 503
>IPL1_ASHGO (Q755C4) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) Length = 367 Score = 55.8 bits (133), Expect = 5e-08 Identities = 42/152 (27%), Positives = 72/152 (47%), Gaps = 3/152 (1%) Frame = +3 Query: 12 FQVYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSN 191 + + E++ NG L HL G+ +A+AL+Y+H + + H DIKP N Sbjct: 183 YLLMEYLVNGELYKHL--KGRSHFNDVVASYYVYQMADALDYMH---ERNILHRDIKPEN 237 Query: 192 VLLDKNYLAKLAGCGIAHCSNGGN---TMVGSTPGTVKIQATPGYVDPEYVVTQELTAKS 362 +++ N KL G + + G+ T+ G T Y+ PE + ++E K Sbjct: 238 IIIGFNNTIKLTDFGWSVITPKGSKRKTLCG----------TVDYLSPELIRSREYNEKV 287 Query: 363 DVYSYGVLLLELVTGRPVVQDDRSLVEWSREL 458 DV++ GVL EL+ G P +++ + + R L Sbjct: 288 DVWALGVLTYELLVGSPPFEEESKELTYKRIL 319
>MLTK_MOUSE (Q9ESL4) Mitogen-activated protein kinase kinase kinase MLT (EC| 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper-and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) ( Length = 802 Score = 55.8 bits (133), Expect = 5e-08 Identities = 36/131 (27%), Positives = 66/131 (50%), Gaps = 2/131 (1%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVL 197 V E+ GSL D+++S+ + ++ + A DVA + YLH + H D+K NV+ Sbjct: 81 VTEYASLGSLYDYINSNRSEEMDMEHIMTWATDVAKGMHYLHMEAPVKVIHRDLKSRNVV 140 Query: 198 LDKNYLAKLAGCGIAHCSNGGN--TMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVY 371 + + + K+ G + N ++VG+ P ++ PE + + ++ D Y Sbjct: 141 IAADGVLKICDFGASRFHNHTTHMSLVGTFP----------WMAPEVIQSLPVSETCDTY 190 Query: 372 SYGVLLLELVT 404 SYGV+L E++T Sbjct: 191 SYGVVLWEMLT 201
>GUC2G_MOUSE (Q6TL19) Guanylate cyclase 2G precursor (EC 4.6.1.2) (Guanylyl| cyclase receptor G) (mGC-G) Length = 1100 Score = 55.8 bits (133), Expect = 5e-08 Identities = 39/132 (29%), Positives = 67/132 (50%), Gaps = 4/132 (3%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVL 197 V ++ + GSL+D + +S + W ++ A D+ N L +LH P HG++KPSN L Sbjct: 631 VTQYCKKGSLQDVMRNSDHEI-DWIFKLSFAYDIVNGLLFLHG--SPLRSHGNLKPSNCL 687 Query: 198 LDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQEL----TAKSD 365 +D + KL+G G+ +G + T + + PE + +E T + D Sbjct: 688 VDSHMQLKLSGFGLWEFKHGSTWRSYNQEATDHSELY--WTAPELLRLRESPCSGTPQGD 745 Query: 366 VYSYGVLLLELV 401 VYS+ +LL +L+ Sbjct: 746 VYSFAILLRDLI 757
>SPKA_SYNY3 (Q9FAB3) Serine/threonine-protein kinase A (EC 2.7.11.1)| Length = 521 Score = 55.8 bits (133), Expect = 5e-08 Identities = 36/101 (35%), Positives = 51/101 (50%), Gaps = 5/101 (4%) Frame = +3 Query: 159 PLYHGDIKPSNVLLDKN----YLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDP 326 P+ H DIKPSNVLL ++ L K+ GIA T T Y P Sbjct: 143 PVVHRDIKPSNVLLVEDPALGELVKILDFGIAKL-----VQAAEESKTQAFMGTLAYCSP 197 Query: 327 EYVVTQELTAKSDVYSYGVLLLELVTGR-PVVQDDRSLVEW 446 E + +EL ++SD+YS GV++ E++TG P+ D+ S W Sbjct: 198 EQMEGKELDSRSDIYSLGVMMYEMLTGEMPLFPDNSSFGGW 238
>KPCG_BOVIN (P05128) Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma)| (Fragment) Length = 682 Score = 55.8 bits (133), Expect = 5e-08 Identities = 42/132 (31%), Positives = 63/132 (47%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVL 197 V E++ G L H+ GK P + A ++A L +LH + + + D+K NV+ Sbjct: 418 VMEYVTGGDLMYHIQQLGKFKEP--HAAFYAAEIAIGLFFLH---NQGIIYRDLKLDNVM 472 Query: 198 LDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVYSY 377 LD K+ G+ C N GST T TP Y+ PE + Q D +S+ Sbjct: 473 LDAEGHIKITDFGM--CKE--NVFPGSTTRT--FCGTPDYIAPEIIAYQPYGKSVDWWSF 526 Query: 378 GVLLLELVTGRP 413 GVLL E++ G+P Sbjct: 527 GVLLYEMLAGQP 538
>KPCG_RAT (P63319) Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma)| Length = 697 Score = 55.8 bits (133), Expect = 5e-08 Identities = 42/132 (31%), Positives = 63/132 (47%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVL 197 V E++ G L H+ GK P + A ++A L +LH + + + D+K NV+ Sbjct: 433 VMEYVTGGDLMYHIQQLGKFKEP--HAAFYAAEIAIGLFFLH---NQGIIYRDLKLDNVM 487 Query: 198 LDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVYSY 377 LD K+ G+ C N GST T TP Y+ PE + Q D +S+ Sbjct: 488 LDAEGHIKITDFGM--CKE--NVFPGSTTRT--FCGTPDYIAPEIIAYQPYGKSVDWWSF 541 Query: 378 GVLLLELVTGRP 413 GVLL E++ G+P Sbjct: 542 GVLLYEMLAGQP 553
>KPCG_MOUSE (P63318) Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma)| Length = 697 Score = 55.8 bits (133), Expect = 5e-08 Identities = 42/132 (31%), Positives = 63/132 (47%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVL 197 V E++ G L H+ GK P + A ++A L +LH + + + D+K NV+ Sbjct: 433 VMEYVTGGDLMYHIQQLGKFKEP--HAAFYAAEIAIGLFFLH---NQGIIYRDLKLDNVM 487 Query: 198 LDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVYSY 377 LD K+ G+ C N GST T TP Y+ PE + Q D +S+ Sbjct: 488 LDAEGHIKITDFGM--CKE--NVFPGSTTRT--FCGTPDYIAPEIIAYQPYGKSVDWWSF 541 Query: 378 GVLLLELVTGRP 413 GVLL E++ G+P Sbjct: 542 GVLLYEMLAGQP 553
>PKNH_MYCTU (Q11053) Probable serine/threonine-protein kinase pknH (EC| 2.7.11.1) Length = 626 Score = 55.5 bits (132), Expect = 7e-08 Identities = 44/154 (28%), Positives = 70/154 (45%), Gaps = 1/154 (0%) Frame = +3 Query: 6 ERFQVYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKP 185 + F +E L L G L P + I +A+AL+ H + H D+KP Sbjct: 88 QMFLEMRLVEGTDLDSVLKRFGPLTPP--RAVAIITQIASALDAAHA---DGVMHRDVKP 142 Query: 186 SNVLLDKNYLAKLAGCGIAHCSNGGN-TMVGSTPGTVKIQATPGYVDPEYVVTQELTAKS 362 N+L+ ++ A L GIA + T +G+ GT K Y+ PE E+T ++ Sbjct: 143 QNILITRDDFAYLVDFGIASATTDEKLTQLGTAVGTWK------YMAPERFSNDEVTYRA 196 Query: 363 DVYSYGVLLLELVTGRPVVQDDRSLVEWSRELIG 464 D+Y+ +L E +TG P + D + S L+G Sbjct: 197 DIYALACVLHECLTGAPPYRADSAGTLVSSHLMG 230
>STK_HYDAT (P17713) Tyrosine-protein kinase STK (EC 2.7.10.2) (P57-STK)| Length = 509 Score = 55.5 bits (132), Expect = 7e-08 Identities = 40/130 (30%), Positives = 61/130 (46%), Gaps = 1/130 (0%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVL 197 V E+M GSL D+L + L I +A VA+ + +L H D+ N+L Sbjct: 311 VTEYMSGGSLLDYLSKGEGVNLQLPTLIDMAAQVASGMAFLEAQ---GYIHRDLAARNIL 367 Query: 198 LDKNYLAKLAGCGIAHCSNGGN-TMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVYS 374 + +NY+ K+A G+A T +K A PE + T KSDV+S Sbjct: 368 VGENYICKVADFGLARLIEDDEYTAHEGAKFPIKWTA------PEAALYNRFTIKSDVWS 421 Query: 375 YGVLLLELVT 404 +G+L+ E+VT Sbjct: 422 FGILMAEIVT 431
>YPK2_YEAST (P18961) Serine/threonine-protein kinase YPK2/YKR2 (EC 2.7.11.1)| Length = 677 Score = 55.5 bits (132), Expect = 7e-08 Identities = 45/149 (30%), Positives = 70/149 (46%) Frame = +3 Query: 12 FQVYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSN 191 + V F+ G L HL G+ L ++R IA ++ AL+ LH + + D+KP N Sbjct: 418 YLVLAFINGGELFYHLQHEGRFSLA-RSRFYIA-ELLCALDSLHKL---DVIYRDLKPEN 472 Query: 192 VLLDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVY 371 +LLD Y +A C C + T TP Y+ PE ++ Q T D + Sbjct: 473 ILLD--YQGHIALCDFGLCKLN----MKDNDKTDTFCGTPEYLAPEILLGQGYTKTVDWW 526 Query: 372 SYGVLLLELVTGRPVVQDDRSLVEWSREL 458 + G+LL E++TG P D+ V + + L Sbjct: 527 TLGILLYEMMTGLPPYYDENVPVMYKKIL 555
>RIPK1_HUMAN (Q13546) Receptor-interacting serine/threonine-protein kinase 1 (EC| 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein) Length = 671 Score = 55.5 bits (132), Expect = 7e-08 Identities = 43/133 (32%), Positives = 67/133 (50%), Gaps = 9/133 (6%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVL 197 V E+ME G+L L + L K RI +++ + YLH + H D+KP N+L Sbjct: 91 VMEYMEKGNLMHVLKAEMSTPLSVKGRI--ILEIIEGMCYLH---GKGVIHKDLKPENIL 145 Query: 198 LDKNYLAKLAGCGIA------HCSNGGNTMVGSTPGTVKIQ-ATPGYVDPEYV--VTQEL 350 +D ++ K+A G+A +N + + GT K T Y+ PE++ V + Sbjct: 146 VDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNGGTLYYMAPEHLNDVNAKP 205 Query: 351 TAKSDVYSYGVLL 389 T KSDVYS+ V+L Sbjct: 206 TEKSDVYSFAVVL 218
>FYN_XIPHE (P27446) Proto-oncogene tyrosine-protein kinase FYN (EC 2.7.10.2)| (P59-FYN) Length = 536 Score = 55.5 bits (132), Expect = 7e-08 Identities = 41/129 (31%), Positives = 59/129 (45%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVL 197 V E+M GSL D L L N + +A VA + Y+ H D++ +N+L Sbjct: 340 VTEYMSKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERM---NYIHRDLRSANIL 396 Query: 198 LDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVYSY 377 + N + K+A G+A N I+ T PE + T KSDV+S+ Sbjct: 397 VGDNLVCKIADFGLARLIED-NEYTARQGAKFPIKWTA----PEAALYGRFTIKSDVWSF 451 Query: 378 GVLLLELVT 404 G+LL ELVT Sbjct: 452 GILLTELVT 460
>KPC1_LYTPI (Q25378) Protein kinase C (EC 2.7.11.13)| Length = 658 Score = 55.5 bits (132), Expect = 7e-08 Identities = 42/136 (30%), Positives = 62/136 (45%), Gaps = 2/136 (1%) Frame = +3 Query: 12 FQVYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSN 191 F V EF+ G L + GK P + + A ++A L YLH + + D+K N Sbjct: 400 FFVMEFVNGGDLMFQIQKVGKFREP--HAVFYAAEIAVGLFYLH---SQGVIYRDLKLDN 454 Query: 192 VLLDKNYLAKLAGCGIA--HCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSD 365 VL+D K+A G+ H + G T TP Y+ PE V Q D Sbjct: 455 VLVDAEGHIKIADFGMCKEHMNEGDTTRT--------FCGTPDYIAPEIVAYQPYGKAVD 506 Query: 366 VYSYGVLLLELVTGRP 413 +++GVLL E++ G+P Sbjct: 507 WWAFGVLLYEMLAGQP 522
>TNI3K_RAT (Q7TQP6) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 834 Score = 55.5 bits (132), Expect = 7e-08 Identities = 44/133 (33%), Positives = 71/133 (53%), Gaps = 3/133 (2%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVL 197 V +++ GSL LH K +L ++++ IA+DVA +EYLH P+ H D+ N+L Sbjct: 537 VTQYISGGSLFSLLHEQ-KRILDLQSKLIIAVDVAKGMEYLHSLTQ-PIIHRDLNSHNIL 594 Query: 198 LDKNYLAKLAGCGIAH-CSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQ--ELTAKSDV 368 L ++ A +A G + + + PG ++ ++ PE V TQ T K+DV Sbjct: 595 LYEDGHAVVADFGESRFLQSLDEDNMTKQPGNLR------WMAPE-VFTQCTRYTIKADV 647 Query: 369 YSYGVLLLELVTG 407 +SY + L EL+TG Sbjct: 648 FSYSLCLWELLTG 660
>PKNH_MYCBO (Q7U095) Probable serine/threonine-protein kinase pknH (EC| 2.7.11.1) Length = 596 Score = 55.5 bits (132), Expect = 7e-08 Identities = 44/154 (28%), Positives = 70/154 (45%), Gaps = 1/154 (0%) Frame = +3 Query: 6 ERFQVYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKP 185 + F +E L L G L P + I +A+AL+ H + H D+KP Sbjct: 88 QMFLEMRLVEGTDLDSVLKRFGPLTPP--RAVAIITQIASALDAAHA---DGVMHRDVKP 142 Query: 186 SNVLLDKNYLAKLAGCGIAHCSNGGN-TMVGSTPGTVKIQATPGYVDPEYVVTQELTAKS 362 N+L+ ++ A L GIA + T +G+ GT K Y+ PE E+T ++ Sbjct: 143 QNILITRDDFAYLVDFGIASATTDEKLTQLGTAVGTWK------YMAPERFSNDEVTYRA 196 Query: 363 DVYSYGVLLLELVTGRPVVQDDRSLVEWSRELIG 464 D+Y+ +L E +TG P + D + S L+G Sbjct: 197 DIYALACVLHECLTGAPPYRADSAGTLVSSHLMG 230
>SHK2_SCHPO (Q10056) Serine/threonine-protein kinase shk2 (EC 2.7.11.1)| Length = 589 Score = 55.1 bits (131), Expect = 9e-08 Identities = 43/136 (31%), Positives = 64/136 (47%), Gaps = 4/136 (2%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVL 197 V E+M GSL D + S L +I ++ +++LH + H DIK NVL Sbjct: 388 VMEYMNAGSLTDIIEKSK---LTEAQIARICLETCKGIQHLHAR---NIIHRDIKSDNVL 441 Query: 198 LDKNYLAKLAGCGI-AHCSNGGN---TMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSD 365 LD + K+ G A SN N TMVG TP ++ PE V E K D Sbjct: 442 LDNSGNIKITDFGFCARLSNRTNKRVTMVG----------TPYWMAPEVVKQNEYGTKVD 491 Query: 366 VYSYGVLLLELVTGRP 413 ++S G++++E++ P Sbjct: 492 IWSLGIMIIEMIENEP 507
>YES_AVISY (P00527) Tyrosine-protein kinase transforming protein YES (EC| 2.7.10.2) (Fragment) Length = 528 Score = 55.1 bits (131), Expect = 9e-08 Identities = 40/129 (31%), Positives = 59/129 (45%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVL 197 V EFM GSL D L L + +A +A+ + Y+ H D++ +N+L Sbjct: 337 VTEFMTKGSLLDFLKEGEGKFLKLPQLVDMAAQIADGMAYIERM---NYIHRDLRAANIL 393 Query: 198 LDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVYSY 377 + N + K+A G+A N I+ T PE + T KSDV+S+ Sbjct: 394 VGDNLVCKIADFGLARLIED-NEYTARQGAKFPIKWTA----PEAALYGRFTIKSDVWSF 448 Query: 378 GVLLLELVT 404 G+LL ELVT Sbjct: 449 GILLTELVT 457
>CDC7_SCHPO (P41892) Cell division control protein 7 (EC 2.7.11.1)| Length = 1062 Score = 55.1 bits (131), Expect = 9e-08 Identities = 43/138 (31%), Positives = 65/138 (47%), Gaps = 2/138 (1%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVL 197 + E+ ENGSL+ + GK+ P V L YLH + + H DIK +N+L Sbjct: 84 ILEYCENGSLRSICKNFGKI--PENLVALYTFQVLQGLLYLH---NQGVIHRDIKGANIL 138 Query: 198 LDKNYLAKLAGCGIAHCSNG--GNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVY 371 K+ KLA G+A N +++VGS P ++ PE + T SD++ Sbjct: 139 TTKDGTIKLADFGVATKINALEDHSVVGS----------PYWMAPEVIELVGATTASDIW 188 Query: 372 SYGVLLLELVTGRPVVQD 425 S G ++EL+ G P D Sbjct: 189 SVGCTVIELLDGNPPYYD 206
>CLA4_CANAL (O14427) Serine/threonine-protein kinase CLA4 (EC 2.7.11.1)| Length = 971 Score = 55.1 bits (131), Expect = 9e-08 Identities = 43/148 (29%), Positives = 68/148 (45%), Gaps = 4/148 (2%) Frame = +3 Query: 6 ERFQVYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKP 185 E + + E+M+ GSL + + ++ L K I + L++LH + H DIK Sbjct: 751 ELWVIMEYMQGGSLTEIIENND-FKLNEKQIATICFETLKGLQHLH---KKHIIHRDIKS 806 Query: 186 SNVLLDKNYLAKLAGCG----IAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELT 353 NVLLD K+ G + N TMVG TP ++ PE V +E Sbjct: 807 DNVLLDAYGNVKITDFGFCAKLTDQRNKRATMVG----------TPYWMAPEVVKQKEYD 856 Query: 354 AKSDVYSYGVLLLELVTGRPVVQDDRSL 437 K DV+S G++ +E++ G P ++ L Sbjct: 857 EKVDVWSLGIMTIEMIEGEPPYLNEEPL 884
>YES_CHICK (P09324) Tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes)| Length = 540 Score = 55.1 bits (131), Expect = 9e-08 Identities = 40/129 (31%), Positives = 59/129 (45%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVL 197 V EFM GSL D L L + +A +A+ + Y+ H D++ +N+L Sbjct: 344 VTEFMTKGSLLDFLKEGEGKFLKLPQLVDMAAQIADGMAYIERM---NYIHRDLRAANIL 400 Query: 198 LDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVYSY 377 + N + K+A G+A N I+ T PE + T KSDV+S+ Sbjct: 401 VGDNLVCKIADFGLARLIED-NEYTARQGAKFPIKWTA----PEAALYGRFTIKSDVWSF 455 Query: 378 GVLLLELVT 404 G+LL ELVT Sbjct: 456 GILLTELVT 464
>LYN_MOUSE (P25911) Tyrosine-protein kinase Lyn (EC 2.7.10.2)| Length = 511 Score = 55.1 bits (131), Expect = 9e-08 Identities = 43/131 (32%), Positives = 64/131 (48%), Gaps = 2/131 (1%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSS--GKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSN 191 + EFM GSL D L S GK+LLP I + +A + Y+ H D++ +N Sbjct: 317 ITEFMAKGSLLDFLKSDEGGKVLLP--KLIDFSAQIAEGMAYIE---RKNYIHRDLRAAN 371 Query: 192 VLLDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVY 371 VL+ ++ + K+A G+A N I+ T PE + T KSDV+ Sbjct: 372 VLVSESLMCKIADFGLARVIED-NEYTAREGAKFPIKWTA----PEAINFGCFTIKSDVW 426 Query: 372 SYGVLLLELVT 404 S+G+LL E+VT Sbjct: 427 SFGILLYEIVT 437
>UNC51_CAEEL (Q23023) Serine/threonine-protein kinase unc-51 (EC 2.7.11.1)| (Uncoordinated protein 51) Length = 856 Score = 55.1 bits (131), Expect = 9e-08 Identities = 43/144 (29%), Positives = 70/144 (48%), Gaps = 11/144 (7%) Frame = +3 Query: 12 FQVYEFMENGSLKDHLHSSGKLLLPWKNRIQ-IAIDVANALEYLHFYCDPPLYHGDIKPS 188 + V EF G L D+L L ++ IQ + +A+ALE ++ + H D+KP Sbjct: 85 YLVMEFCNGGDLADYLQQKTTLN---EDTIQHFVVQIAHALEAIN---KKGIVHRDLKPQ 138 Query: 189 NVLLDKN----------YLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVV 338 N+LL N + KLA G A N G M + G+ P Y+ PE ++ Sbjct: 139 NILLCNNSRTQNPHFTDIVIKLADFGFARFLNDG-VMAATLCGS------PMYMAPEVIM 191 Query: 339 TQELTAKSDVYSYGVLLLELVTGR 410 + + AK+D++S G +L + +TG+ Sbjct: 192 SMQYDAKADLWSIGTILFQCLTGK 215
>PKNK_MYCBO (Q7TXA9) Probable serine/threonine-protein kinase pknK (EC| 2.7.11.1) Length = 1110 Score = 55.1 bits (131), Expect = 9e-08 Identities = 41/132 (31%), Positives = 57/132 (43%) Frame = +3 Query: 12 FQVYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSN 191 F V + SL+ + G L W+ + I + +A ALE H H D+KP N Sbjct: 100 FIVMPYHAKNSLETLIRRHGPL--DWRETLSIGVKLAGALEAAHRV---GTLHRDVKPGN 154 Query: 192 VLLDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVY 371 +LL +L GIA + G T G G +P + PE + T SDVY Sbjct: 155 ILLTDYGEPQLTDFGIARIAGGFETATGVIAG------SPAFTAPEVLEGASPTPASDVY 208 Query: 372 SYGVLLLELVTG 407 S G L ++TG Sbjct: 209 SLGATLFCVLTG 220
>MLTK_HUMAN (Q9NYL2) Mitogen-activated protein kinase kinase kinase MLT (EC| 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper-and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase Length = 800 Score = 55.1 bits (131), Expect = 9e-08 Identities = 36/131 (27%), Positives = 65/131 (49%), Gaps = 2/131 (1%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVL 197 V E+ GSL D+++S+ + + + A DVA + YLH + H D+K NV+ Sbjct: 81 VTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAPVKVIHRDLKSRNVV 140 Query: 198 LDKNYLAKLAGCGIAHCSNGGN--TMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVY 371 + + + K+ G + N ++VG+ P ++ PE + + ++ D Y Sbjct: 141 IAADGVLKICDFGASRFHNHTTHMSLVGTFP----------WMAPEVIQSLPVSETCDTY 190 Query: 372 SYGVLLLELVT 404 SYGV+L E++T Sbjct: 191 SYGVVLWEMLT 201
>KPC2_DROME (P13677) Protein kinase C, eye isozyme (EC 2.7.11.13) (PKC)| (dPKC53E(EY)) (Protein INAC) (Inactivation no after-potential C protein) (Photoreceptor-specific PKC) (Eye-PKC) Length = 700 Score = 54.7 bits (130), Expect = 1e-07 Identities = 45/146 (30%), Positives = 69/146 (47%), Gaps = 3/146 (2%) Frame = +3 Query: 12 FQVYEFMENGSLKDHLHSSGKLLLPWKNRIQI--AIDVANALEYLHFYCDPPLYHGDIKP 185 F V E+ + G L H+ G+ +K + I A++VA AL +LH + + + D+K Sbjct: 446 FFVMEYCKGGDLMYHMQQYGR----FKESVAIFYAVEVAIALFFLH---ERDIIYRDLKL 498 Query: 186 SNVLLDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSD 365 N+LLD KL G++ V T TP Y+ PE V + +D Sbjct: 499 DNILLDGEGHVKLVDFGLS------KEGVTERQTTRTFCGTPNYMAPEIVSYDPYSIAAD 552 Query: 366 VYSYGVLLLELVTGR-PVVQDDRSLV 440 +S+GVLL E + G+ P DD + V Sbjct: 553 WWSFGVLLFEFMAGQAPFEGDDETTV 578
>PKN2_MYXXA (P54736) Serine/threonine-protein kinase pkn2 (EC 2.7.11.1)| Length = 830 Score = 54.7 bits (130), Expect = 1e-07 Identities = 43/134 (32%), Positives = 63/134 (47%), Gaps = 3/134 (2%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVL 197 V EF+E SL D L +P + + +A L +H D + H D+KP NV Sbjct: 89 VMEFVEGESLYDVLTPGP---MPPGRALPLLQQLAEGLAAIH---DKGIIHRDLKPENVF 142 Query: 198 LDKNYL---AKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDV 368 + K+ A+L GIA S G V TP Y+ PE V ++ +SD+ Sbjct: 143 ISKSARGEQARLLDFGIARLVEPDAASSVSQIGVVL--GTPEYLSPEQAVGAKVDTRSDL 200 Query: 369 YSYGVLLLELVTGR 410 YS+GVL +++GR Sbjct: 201 YSFGVLTYRVLSGR 214
>STE7_YEAST (P06784) Serine/threonine-protein kinase STE7 (EC 2.7.12.2)| Length = 515 Score = 54.7 bits (130), Expect = 1e-07 Identities = 38/112 (33%), Positives = 57/112 (50%), Gaps = 5/112 (4%) Frame = +3 Query: 87 WKNRI---QIAIDVANALEYLHFYCDPPLYHGDIKPSNVLLDKNYLAKLAGCGIAH--CS 251 W N + +IA V N L+ H Y + H DIKPSNVL++ KL G++ + Sbjct: 301 WFNELTISKIAYGVLNGLD--HLYRQYKIIHRDIKPSNVLINSKGQIKLCDFGVSKKLIN 358 Query: 252 NGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVYSYGVLLLELVTG 407 + +T VG T Y+ PE + + K DV+S G++++ELVTG Sbjct: 359 SIADTFVG----------TSTYMSPERIQGNVYSIKGDVWSLGLMIIELVTG 400
>YRK_CHICK (Q02977) Proto-oncogene tyrosine-protein kinase Yrk (EC 2.7.10.2)| (p60-Yrk) (Yes-related kinase) Length = 535 Score = 54.7 bits (130), Expect = 1e-07 Identities = 40/129 (31%), Positives = 59/129 (45%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVL 197 V EFM GSL D L L + +A +A + Y+ H D++ +N+L Sbjct: 339 VTEFMSQGSLLDFLKDGDGRYLKLPQLVDMAAQIAAGMAYIERM---NYIHRDLRAANIL 395 Query: 198 LDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVYSY 377 + N + K+A G+A N I+ T PE + + T KSDV+S+ Sbjct: 396 VGDNLVCKIADFGLARLIED-NEYTARQGAKFPIKWTA----PEAALFGKFTIKSDVWSF 450 Query: 378 GVLLLELVT 404 G+LL ELVT Sbjct: 451 GILLTELVT 459
>SPK1_DUGTI (P42687) Tyrosine-protein kinase SPK-1 (EC 2.7.10.2)| Length = 497 Score = 54.7 bits (130), Expect = 1e-07 Identities = 31/129 (24%), Positives = 67/129 (51%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVL 197 + E+M+NGSLK++L + + + +++ + YL + H D++ N+L Sbjct: 293 IVEYMKNGSLKEYLKTPDGKKTNLNQMVHMMAEISEGMAYLE---SEKVVHRDLRADNIL 349 Query: 198 LDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVYSY 377 + + K+A G+ ++G ++ T++ + PE ++ T+KSDV+SY Sbjct: 350 VANDLTRKVADFGLTELTDG--SLGDQEKKTLRFPYK--WTAPEAAKSKVFTSKSDVWSY 405 Query: 378 GVLLLELVT 404 G+++ E++T Sbjct: 406 GIVMFEILT 414
>KPCZ_RABIT (O19111) Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta)| Length = 591 Score = 54.7 bits (130), Expect = 1e-07 Identities = 41/133 (30%), Positives = 64/133 (48%) Frame = +3 Query: 12 FQVYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSN 191 F V E++ G L H+ KL P ++ A ++ AL +LH + + + D+K N Sbjct: 326 FLVIEYVNGGDLMFHMQRQRKL--PEEHARFYAAEICIALNFLH---ERGIIYRDLKLDN 380 Query: 192 VLLDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVY 371 VLLD + KL G+ C G +G T TP Y+ PE + +E D + Sbjct: 381 VLLDADGHIKLTDYGM--CKEG----LGPGDTTSTFCGTPNYIAPEILRGEEYGFSVDWW 434 Query: 372 SYGVLLLELVTGR 410 + GVL+ E++ GR Sbjct: 435 ALGVLMFEMMAGR 447
>KPCT_HUMAN (Q04759) Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta)| Length = 706 Score = 54.7 bits (130), Expect = 1e-07 Identities = 39/133 (29%), Positives = 65/133 (48%) Frame = +3 Query: 12 FQVYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSN 191 F V E++ G L H+ S K L A ++ L++LH + + D+K N Sbjct: 455 FFVMEYLNGGDLMYHIQSCHKFDL--SRATFYAAEIILGLQFLH---SKGIVYRDLKLDN 509 Query: 192 VLLDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVY 371 +LLDK+ K+A G+ + G+ + GT P Y+ PE ++ Q+ D + Sbjct: 510 ILLDKDGHIKIADFGMCKENMLGDAKTNTFCGT------PDYIAPEILLGQKYNHSVDWW 563 Query: 372 SYGVLLLELVTGR 410 S+GVLL E++ G+ Sbjct: 564 SFGVLLYEMLIGQ 576
>KAPC_CAEEL (P21137) cAMP-dependent protein kinase catalytic subunit (EC| 2.7.11.11) (PKA C) Length = 404 Score = 54.7 bits (130), Expect = 1e-07 Identities = 40/151 (26%), Positives = 65/151 (43%) Frame = +3 Query: 12 FQVYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSN 191 + V EF+ G + HL G+ P A + A EYLH L + D+KP N Sbjct: 155 YMVLEFISGGEMFSHLRRIGRFSEPHSRFY--AAQIVLAFEYLHSL---DLIYRDLKPEN 209 Query: 192 VLLDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVY 371 +L+D K+ G A G T + TP Y+ PE ++++ D + Sbjct: 210 LLIDSTGYLKITDFGFAKRVKGR---------TWTLCGTPEYLAPEIILSKGYNKAVDWW 260 Query: 372 SYGVLLLELVTGRPVVQDDRSLVEWSRELIG 464 + GVL+ E+ G P D+ + + + + G Sbjct: 261 ALGVLIYEMAAGYPPFFADQPIQIYEKIVSG 291
>FYN_XENLA (P13406) Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2)| (p59-Fyn) Length = 536 Score = 54.7 bits (130), Expect = 1e-07 Identities = 40/129 (31%), Positives = 58/129 (44%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVL 197 V E+M GSL D L L N + +A VA + Y+ H D++ +N+L Sbjct: 340 VTEYMSKGSLLDFLKDGEGRALKLPNLVDMAAQVARGMAYIERM---NYIHRDLRSANIL 396 Query: 198 LDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVYSY 377 + + K+A G+A N I+ T PE + T KSDV+S+ Sbjct: 397 VGNGLICKIADFGLARLIED-NEYTARQGAKFPIKWTA----PEAALYGRFTIKSDVWSF 451 Query: 378 GVLLLELVT 404 G+LL ELVT Sbjct: 452 GILLTELVT 460
>MATK_RAT (P41243) Megakaryocyte-associated tyrosine-protein kinase (EC| 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase BATK) Length = 467 Score = 54.7 bits (130), Expect = 1e-07 Identities = 36/127 (28%), Positives = 62/127 (48%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVL 197 V E + G+L + L + G+ L+ +Q A+ VA +EYL L H D+ N+L Sbjct: 262 VMEHVSKGNLVNFLRTRGRALVSTSQLLQFALHVAEGMEYLE---SKKLVHRDLAARNIL 318 Query: 198 LDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVYSY 377 + ++ +AK++ G+A G + + PE + ++KSDV+S+ Sbjct: 319 VSEDLVAKVSDFGLAKAE--------LRKGLDSSRLPVKWTAPEALKNGRFSSKSDVWSF 370 Query: 378 GVLLLEL 398 GVLL E+ Sbjct: 371 GVLLWEV 377
>KPCZ_RAT (P09217) Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta)| Length = 592 Score = 54.7 bits (130), Expect = 1e-07 Identities = 41/133 (30%), Positives = 64/133 (48%) Frame = +3 Query: 12 FQVYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSN 191 F V E++ G L H+ KL P ++ A ++ AL +LH + + + D+K N Sbjct: 327 FLVIEYVNGGDLMFHMQRQRKL--PEEHARFYAAEICIALNFLH---ERGIIYRDLKLDN 381 Query: 192 VLLDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVY 371 VLLD + KL G+ C G +G T TP Y+ PE + +E D + Sbjct: 382 VLLDADGHIKLTDYGM--CKEG----LGPGDTTSTFCGTPNYIAPEILRGEEYGFSVDWW 435 Query: 372 SYGVLLLELVTGR 410 + GVL+ E++ GR Sbjct: 436 ALGVLMFEMMAGR 448
>KPCZ_MOUSE (Q02956) Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta)| Length = 592 Score = 54.7 bits (130), Expect = 1e-07 Identities = 41/133 (30%), Positives = 64/133 (48%) Frame = +3 Query: 12 FQVYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSN 191 F V E++ G L H+ KL P ++ A ++ AL +LH + + + D+K N Sbjct: 327 FLVIEYVNGGDLMFHMQRQRKL--PEEHARFYAAEICIALNFLH---ERGIIYRDLKLDN 381 Query: 192 VLLDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVY 371 VLLD + KL G+ C G +G T TP Y+ PE + +E D + Sbjct: 382 VLLDADGHIKLTDYGM--CKEG----LGPGDTTSTFCGTPNYIAPEILRGEEYGFSVDWW 435 Query: 372 SYGVLLLELVTGR 410 + GVL+ E++ GR Sbjct: 436 ALGVLMFEMMAGR 448
>KPCZ_HUMAN (Q05513) Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta)| Length = 592 Score = 54.7 bits (130), Expect = 1e-07 Identities = 41/133 (30%), Positives = 64/133 (48%) Frame = +3 Query: 12 FQVYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSN 191 F V E++ G L H+ KL P ++ A ++ AL +LH + + + D+K N Sbjct: 327 FLVIEYVNGGDLMFHMQRQRKL--PEEHARFYAAEICIALNFLH---ERGIIYRDLKLDN 381 Query: 192 VLLDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVY 371 VLLD + KL G+ C G +G T TP Y+ PE + +E D + Sbjct: 382 VLLDADGHIKLTDYGM--CKEG----LGPGDTTSTFCGTPNYIAPEILRGEEYGFSVDWW 435 Query: 372 SYGVLLLELVTGR 410 + GVL+ E++ GR Sbjct: 436 ALGVLMFEMMAGR 448
>GAD8_SCHPO (Q9P7J8) Serine/threonine-protein kinase gad8 (EC 2.7.11.1)| Length = 569 Score = 54.7 bits (130), Expect = 1e-07 Identities = 43/139 (30%), Positives = 65/139 (46%) Frame = +3 Query: 12 FQVYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSN 191 + V F+ G L HL G ++ + IA ++ ALE LH + + + D+KP N Sbjct: 304 YLVLAFVNGGELFHHLQREG-CFDTYRAKFYIA-ELLVALECLHEF---NVIYRDLKPEN 358 Query: 192 VLLDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVY 371 +LLD Y +A C C + T T TP Y+ PE ++ T D + Sbjct: 359 ILLD--YTGHIALCDFGLCKLN----MAKTDRTNTFCGTPEYLAPELLLGHGYTKVVDWW 412 Query: 372 SYGVLLLELVTGRPVVQDD 428 + GVLL E++TG P D+ Sbjct: 413 TLGVLLYEMITGLPPFYDE 431
>LRRK2_HUMAN (Q5S007) Leucine-rich repeat serine/threonine-protein kinase 2 (EC| 2.7.11.1) (Dardarin) Length = 2527 Score = 54.7 bits (130), Expect = 1e-07 Identities = 49/140 (35%), Positives = 67/140 (47%), Gaps = 8/140 (5%) Frame = +3 Query: 9 RFQVYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPS 188 R V E GSL D L K L + +IA+ VA+ L YLH + + D+KP Sbjct: 1943 RMLVMELASKGSL-DRLLQQDKASLTRTLQHRIALHVADGLRYLH---SAMIIYRDLKPH 1998 Query: 189 NVLLDKNY-----LAKLAGCGIAH--CSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQE 347 NVLL Y +AK+A GIA C G T G TPG+ PE Sbjct: 1999 NVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEG----------TPGFRAPEVARGNV 2048 Query: 348 L-TAKSDVYSYGVLLLELVT 404 + ++DVYS+G+LL +++T Sbjct: 2049 IYNQQADVYSFGLLLYDILT 2068
>MEK2_CAEEL (Q10664) Dual specificity mitogen-activated protein kinase kinase| mek-2 (EC 2.7.12.2) (MAP kinase kinase mek-2) Length = 387 Score = 54.7 bits (130), Expect = 1e-07 Identities = 42/131 (32%), Positives = 65/131 (49%), Gaps = 2/131 (1%) Frame = +3 Query: 24 EFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVLLD 203 E+M+ SL L G+L + RI +A V L YL + + H D+KPSN+L++ Sbjct: 149 EYMDGLSLDIVLKKVGRLPEKFVGRISVA--VVRGLTYLKD--EIKILHRDVKPSNMLVN 204 Query: 204 KNYLAKLAGCGIAHC--SNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVYSY 377 N KL G++ + N+ VG T Y+ PE + T SD++S+ Sbjct: 205 SNGEIKLCDFGVSGMLIDSMANSFVG----------TRSYMAPERLTGSHYTISSDIWSF 254 Query: 378 GVLLLELVTGR 410 G+ L+EL+ GR Sbjct: 255 GLSLVELLIGR 265
>SKM1_YEAST (Q12469) Serine/threonine-protein kinase SKM1 (EC 2.7.11.1)| (Protein kinase 75490 D) Length = 655 Score = 54.7 bits (130), Expect = 1e-07 Identities = 44/145 (30%), Positives = 68/145 (46%), Gaps = 9/145 (6%) Frame = +3 Query: 6 ERFQVYEFMENGSLKDHLHS-----SGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYH 170 E + + E+ME G L D L + +G+ P N Q+A V + L F + + H Sbjct: 447 ELWVIMEYMEGGCLTDILDAVARSNTGEHSSPL-NENQMAYIVKETCQGLKFLHNKKIIH 505 Query: 171 GDIKPSNVLLDKNYLAKLAGCG----IAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVV 338 DIK N+LL+ L K+ G + + TMVG TP ++ PE V Sbjct: 506 RDIKSDNILLNSQGLVKITDFGFCVELTEKRSKRATMVG----------TPYWMAPEIVN 555 Query: 339 TQELTAKSDVYSYGVLLLELVTGRP 413 + K DV+S G++L+E++ G P Sbjct: 556 QKGYDEKVDVWSLGIMLIEMIEGEP 580
>KAPC_DROME (P12370) cAMP-dependent protein kinase catalytic subunit (EC| 2.7.11.11) (PKA C) Length = 352 Score = 54.7 bits (130), Expect = 1e-07 Identities = 39/151 (25%), Positives = 66/151 (43%) Frame = +3 Query: 12 FQVYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSN 191 + V E++ G + HL G+ P A + A EYLH+ L + D+KP N Sbjct: 119 YMVLEYVPGGEMFSHLRKVGRFSEPHSRFY--AAQIVLAFEYLHYL---DLIYRDLKPEN 173 Query: 192 VLLDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVY 371 +L+D K+ G A G T + TP Y+ PE ++++ D + Sbjct: 174 LLIDSQGYLKVTDFGFAKRVKGR---------TWTLCGTPEYLAPEIILSKGYNKAVDWW 224 Query: 372 SYGVLLLELVTGRPVVQDDRSLVEWSRELIG 464 + GVL+ E+ G P D+ + + + + G Sbjct: 225 ALGVLVYEMAAGYPPFFADQPIQIYEKIVSG 255
>KPCG_RABIT (P10829) Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma)| (PKC-delta) Length = 697 Score = 54.7 bits (130), Expect = 1e-07 Identities = 41/132 (31%), Positives = 63/132 (47%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVL 197 V E++ G L H+ GK P + A ++A L +LH + + + D+K NV+ Sbjct: 433 VMEYVTGGDLMYHIQQLGKFKEP--HAAFYAAEIAIGLFFLH---NQGIIYRDLKLDNVM 487 Query: 198 LDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVYSY 377 LD K+ G+ C N G+T T TP Y+ PE + Q D +S+ Sbjct: 488 LDAEGHIKITDFGM--CKE--NVFPGTTTRT--FCGTPDYIAPEIIAYQPYGKSVDWWSF 541 Query: 378 GVLLLELVTGRP 413 GVLL E++ G+P Sbjct: 542 GVLLYEMLAGQP 553
>KPCG_HUMAN (P05129) Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma)| Length = 697 Score = 54.7 bits (130), Expect = 1e-07 Identities = 41/132 (31%), Positives = 63/132 (47%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVL 197 V E++ G L H+ GK P + A ++A L +LH + + + D+K NV+ Sbjct: 433 VMEYVTGGDLMYHIQQLGKFKEP--HAAFYAAEIAIGLFFLH---NQGIIYRDLKLDNVM 487 Query: 198 LDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVYSY 377 LD K+ G+ C N G+T T TP Y+ PE + Q D +S+ Sbjct: 488 LDAEGHIKITDFGM--CKE--NVFPGTTTRT--FCGTPDYIAPEIIAYQPYGKSVDWWSF 541 Query: 378 GVLLLELVTGRP 413 GVLL E++ G+P Sbjct: 542 GVLLYEMLAGQP 553
>KPC1_DROME (P05130) Protein kinase C, brain isozyme (EC 2.7.11.13) (PKC)| (dPKC53E(BR)) Length = 679 Score = 54.3 bits (129), Expect = 2e-07 Identities = 41/134 (30%), Positives = 63/134 (47%) Frame = +3 Query: 12 FQVYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSN 191 F V E++ G L + GK P + A ++A L +LH + + D+K N Sbjct: 425 FFVMEYVNGGDLMFQIQQFGKFKEPVA--VFYAAEIAAGLFFLH---TKGILYRDLKLDN 479 Query: 192 VLLDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVY 371 VLLD + K+A G+ +VG T TP Y+ PE ++ Q D + Sbjct: 480 VLLDADGHVKIADFGMCK-----ENIVGDKT-TKTFCGTPDYIAPEIILYQPYGKSVDWW 533 Query: 372 SYGVLLLELVTGRP 413 +YGVLL E++ G+P Sbjct: 534 AYGVLLYEMLVGQP 547
>TNI3K_HUMAN (Q59H18) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 936 Score = 54.3 bits (129), Expect = 2e-07 Identities = 43/133 (32%), Positives = 71/133 (53%), Gaps = 3/133 (2%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVL 197 V +++ GSL LH K +L ++++ IA+DVA +EYLH P+ H D+ N+L Sbjct: 639 VTQYISGGSLFSLLHEQ-KRILDLQSKLIIAVDVAKGMEYLH-NLTQPIIHRDLNSHNIL 696 Query: 198 LDKNYLAKLAGCGIAH-CSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQ--ELTAKSDV 368 L ++ A +A G + + + PG ++ ++ PE V TQ T K+DV Sbjct: 697 LYEDGHAVVADFGESRFLQSLDEDNMTKQPGNLR------WMAPE-VFTQCTRYTIKADV 749 Query: 369 YSYGVLLLELVTG 407 +SY + L E++TG Sbjct: 750 FSYALCLWEILTG 762
>LCK_MOUSE (P06240) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) Length = 508 Score = 54.3 bits (129), Expect = 2e-07 Identities = 37/129 (28%), Positives = 61/129 (47%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVL 197 + E+MENGSL D L + + L + +A +A + ++ + H D++ +N+L Sbjct: 314 ITEYMENGSLVDFLKTPSGIKLNVNKLLDMAAQIAEGMAFIE---EQNYIHRDLRAANIL 370 Query: 198 LDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVYSY 377 + K+A G+A N I+ T PE + T KSDV+S+ Sbjct: 371 VSDTLSCKIADFGLARLIED-NEYTAREGAKFPIKWTA----PEAINYGTFTIKSDVWSF 425 Query: 378 GVLLLELVT 404 G+LL E+VT Sbjct: 426 GILLTEIVT 434
>LCK_HUMAN (P06239) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell-specific protein-tyrosine kinase) Length = 508 Score = 54.3 bits (129), Expect = 2e-07 Identities = 37/129 (28%), Positives = 61/129 (47%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVL 197 + E+MENGSL D L + + L + +A +A + ++ + H D++ +N+L Sbjct: 314 ITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIE---ERNYIHRDLRAANIL 370 Query: 198 LDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVYSY 377 + K+A G+A N I+ T PE + T KSDV+S+ Sbjct: 371 VSDTLSCKIADFGLARLIED-NEYTAREGAKFPIKWTA----PEAINYGTFTIKSDVWSF 425 Query: 378 GVLLLELVT 404 G+LL E+VT Sbjct: 426 GILLTEIVT 434
>LCK_AOTNA (Q5PXS1) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) Length = 508 Score = 54.3 bits (129), Expect = 2e-07 Identities = 37/129 (28%), Positives = 61/129 (47%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVL 197 + E+MENGSL D L + + L + +A +A + ++ + H D++ +N+L Sbjct: 314 ITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIE---ERNYIHRDLRAANIL 370 Query: 198 LDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVYSY 377 + K+A G+A N I+ T PE + T KSDV+S+ Sbjct: 371 VSDTLSCKIADFGLARLIED-NEYTAREGAKFPIKWTA----PEAINYGTFTIKSDVWSF 425 Query: 378 GVLLLELVT 404 G+LL E+VT Sbjct: 426 GILLTEIVT 434
>KPCA_RAT (P05696) Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha)| (PKC-A) Length = 671 Score = 54.3 bits (129), Expect = 2e-07 Identities = 41/132 (31%), Positives = 63/132 (47%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVL 197 V E++ G L H+ GK P + A +++ L +LH + + D+K NV+ Sbjct: 415 VMEYVNGGDLMYHIQQVGKFKEP--QAVFYAAEISIGLFFLH---KRGIIYRDLKLDNVM 469 Query: 198 LDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVYSY 377 LD K+A G+ C + M G T T TP Y+ PE + Q D ++Y Sbjct: 470 LDSEGHIKIADFGM--CKE--HMMDGVTTRT--FCGTPDYIAPEIIAYQPYGKSVDWWAY 523 Query: 378 GVLLLELVTGRP 413 GVLL E++ G+P Sbjct: 524 GVLLYEMLAGQP 535
>KPCA_RABIT (P10102) Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha)| (PKC-A) Length = 671 Score = 54.3 bits (129), Expect = 2e-07 Identities = 41/132 (31%), Positives = 63/132 (47%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVL 197 V E++ G L H+ GK P + A +++ L +LH + + D+K NV+ Sbjct: 415 VMEYVNGGDLMYHIQQVGKFKEP--QAVFYAAEISIGLFFLH---KRGIIYRDLKLDNVM 469 Query: 198 LDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVYSY 377 LD K+A G+ C + M G T T TP Y+ PE + Q D ++Y Sbjct: 470 LDSEGHIKIADFGM--CKE--HMMDGVTTRT--FCGTPDYIAPEIIAYQPYGKSVDWWAY 523 Query: 378 GVLLLELVTGRP 413 GVLL E++ G+P Sbjct: 524 GVLLYEMLAGQP 535
>KPCA_HUMAN (P17252) Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha)| (PKC-A) Length = 671 Score = 54.3 bits (129), Expect = 2e-07 Identities = 41/132 (31%), Positives = 63/132 (47%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVL 197 V E++ G L H+ GK P + A +++ L +LH + + D+K NV+ Sbjct: 415 VMEYVNGGDLMYHIQQVGKFKEP--QAVFYAAEISIGLFFLH---KRGIIYRDLKLDNVM 469 Query: 198 LDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVYSY 377 LD K+A G+ C + M G T T TP Y+ PE + Q D ++Y Sbjct: 470 LDSEGHIKIADFGM--CKE--HMMDGVTTRT--FCGTPDYIAPEIIAYQPYGKSVDWWAY 523 Query: 378 GVLLLELVTGRP 413 GVLL E++ G+P Sbjct: 524 GVLLYEMLAGQP 535
>KPCA_BOVIN (P04409) Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha)| (PKC-A) Length = 671 Score = 54.3 bits (129), Expect = 2e-07 Identities = 41/132 (31%), Positives = 63/132 (47%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVL 197 V E++ G L H+ GK P + A +++ L +LH + + D+K NV+ Sbjct: 415 VMEYVNGGDLMYHIQQVGKFKEP--QAVFYAAEISIGLFFLH---KRGIIYRDLKLDNVM 469 Query: 198 LDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVYSY 377 LD K+A G+ C + M G T T TP Y+ PE + Q D ++Y Sbjct: 470 LDSEGHIKIADFGM--CKE--HMMDGVTTRT--FCGTPDYIAPEIIAYQPYGKSVDWWAY 523 Query: 378 GVLLLELVTGRP 413 GVLL E++ G+P Sbjct: 524 GVLLYEMLAGQP 535
>YES_MOUSE (Q04736) Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2)| (p61-Yes) (c-Yes) Length = 540 Score = 54.3 bits (129), Expect = 2e-07 Identities = 39/129 (30%), Positives = 59/129 (45%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVL 197 V EFM GSL D L L + +A +A+ + Y+ H D++ +N+L Sbjct: 344 VTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERM---NYIHRDLRAANIL 400 Query: 198 LDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVYSY 377 + +N + K+A G+A N I+ T PE + T KSDV+S+ Sbjct: 401 VGENLICKIADFGLARLIED-NEYTARQGAKFPIKWTA----PEAALYGRFTIKSDVWSF 455 Query: 378 GVLLLELVT 404 G+L ELVT Sbjct: 456 GILQTELVT 464
>ABL_DROME (P00522) Tyrosine-protein kinase Abl (EC 2.7.10.2) (Abelson| protein) (D-ash) Length = 1620 Score = 54.3 bits (129), Expect = 2e-07 Identities = 39/129 (30%), Positives = 62/129 (48%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVL 197 + EFM +G+L D L S+G+ L + +A +A+ + YL H D+ N L Sbjct: 443 ITEFMSHGNLLDFLRSAGRETLDAVALLYMATQIASGMSYLE---SRNYIHRDLAARNCL 499 Query: 198 LDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVYSY 377 + N L K+A G+A +T I+ T PE + + + KSDV+++ Sbjct: 500 VGDNKLVKVADFGLARLMRD-DTYTAHAGAKFPIKWTA----PEGLAYNKFSTKSDVWAF 554 Query: 378 GVLLLELVT 404 GVLL E+ T Sbjct: 555 GVLLWEIAT 563
>KDC2_DROME (P16912) Protein kinase DC2 (EC 2.7.11.1)| Length = 583 Score = 54.3 bits (129), Expect = 2e-07 Identities = 38/159 (23%), Positives = 73/159 (45%), Gaps = 10/159 (6%) Frame = +3 Query: 12 FQVYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSN 191 + +++++ G L +L ++GK N A ++ +ALEYLH + + D+KP N Sbjct: 348 YMIFDYVCGGELFTYLRNAGKFTSQTSNFY--AAEIVSALEYLHSL---QIVYRDLKPEN 402 Query: 192 VLLDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVY 371 +L++++ K+ G A T + TP Y+ PE + ++ D + Sbjct: 403 LLINRDGHLKITDFGFAKKLRDR---------TWTLCGTPEYIAPEIIQSKGHNKAVDWW 453 Query: 372 SYGVLLLELVTGRPVVQDDRSL----------VEWSREL 458 + GVL+ E++ G P D++ +EW R + Sbjct: 454 ALGVLIYEMLVGYPPFYDEQPFGIYEKILSGKIEWERHM 492
>IPL1_CANGA (Q6FV07) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) Length = 358 Score = 54.3 bits (129), Expect = 2e-07 Identities = 45/153 (29%), Positives = 75/153 (49%), Gaps = 5/153 (3%) Frame = +3 Query: 15 QVYEFMENGSLKDHLHSSGKLLLPWKNRI--QIAIDVANALEYLHFYCDPPLYHGDIKPS 188 +VY ME+ S+ L+ S K P+ + + +A+AL Y+H + H D+KP Sbjct: 172 RVYLLMEH-SINGELYKSLKNNGPFNDVLASHYIYQIADALHYMH---KKRIIHRDVKPE 227 Query: 189 NVLLDKNYLAKLAGCGIAHCSNGGN---TMVGSTPGTVKIQATPGYVDPEYVVTQELTAK 359 NVL+ + + KLA G + + G+ T+ G T Y+ PE + +E + Sbjct: 228 NVLIGFDNVVKLADFGWSILNPEGSKRKTLCG----------TIDYLSPEMITPREYDEQ 277 Query: 360 SDVYSYGVLLLELVTGRPVVQDDRSLVEWSREL 458 DV++ GVL ELV G P +++ + + R L Sbjct: 278 VDVWALGVLAYELVVGVPPFEENSKELTYKRIL 310
>PKNK_MYCTU (P95078) Probable serine/threonine-protein kinase pknK (EC| 2.7.11.1) Length = 1110 Score = 54.3 bits (129), Expect = 2e-07 Identities = 41/132 (31%), Positives = 56/132 (42%) Frame = +3 Query: 12 FQVYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSN 191 F V + SL+ + G L W+ + I + +A ALE H H D+KP N Sbjct: 100 FIVMPYHAKNSLETLIRRHGPL--DWRETLSIGVKLAGALEAAHRV---GTLHRDVKPGN 154 Query: 192 VLLDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVY 371 +LL +L GIA + G T G G +P + PE + T SDVY Sbjct: 155 ILLTDYGEPQLTDFGIARIAGGFETATGVIAG------SPAFTAPEVLEGASPTPASDVY 208 Query: 372 SYGVLLLELVTG 407 S G L +TG Sbjct: 209 SLGATLFCALTG 220
>SKH1_SCHPO (Q9Y884) MAP kinase kinase skh1/pek1 (EC 2.7.12.2)| Length = 363 Score = 53.9 bits (128), Expect = 2e-07 Identities = 36/103 (34%), Positives = 50/103 (48%) Frame = +3 Query: 102 QIAIDVANALEYLHFYCDPPLYHGDIKPSNVLLDKNYLAKLAGCGIAHCSNGGNTMVGST 281 +IA V + L YLH D + H DIKPSN+LL KL G++ +V S Sbjct: 185 KIAFGVLSGLSYLH---DRKIIHRDIKPSNILLTSKGQVKLCDFGVS------GELVNSL 235 Query: 282 PGTVKIQATPGYVDPEYVVTQELTAKSDVYSYGVLLLELVTGR 410 GT T Y+ PE + T SD++S G+ L+E+ R Sbjct: 236 AGT--FTGTSYYMAPERISGGSYTISSDIWSLGLTLMEVALNR 276
>ABL_FSVHY (P10447) Tyrosine-protein kinase transforming protein Abl (EC| 2.7.10.2) (V-abl) Length = 439 Score = 53.9 bits (128), Expect = 2e-07 Identities = 38/130 (29%), Positives = 64/130 (49%), Gaps = 1/130 (0%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVL 197 + EFM G+L D+L + + + +A +++A+EYL H D+ N L Sbjct: 263 ITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLE---KKNFIHRDLAARNCL 319 Query: 198 LDKNYLAKLAGCGIAHCSNGGN-TMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVYS 374 + +N+L K+A G++ G T T +K A PE + + + KSDV++ Sbjct: 320 VGENHLVKVADFGLSRLMTGDTYTAHAGTKFPIKWTA------PESLAYNKFSIKSDVWA 373 Query: 375 YGVLLLELVT 404 +GVLL E+ T Sbjct: 374 FGVLLWEIAT 383
>ABL1_MOUSE (P00520) Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2)| (p150) (c-ABL) (Abelson murine leukemia viral oncogene homolog 1) Length = 1123 Score = 53.9 bits (128), Expect = 2e-07 Identities = 37/129 (28%), Positives = 64/129 (49%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVL 197 + EFM G+L D+L + + + +A +++A+EYL H D+ N L Sbjct: 314 ITEFMTYGNLLDYLRECNRQEVSAVVLLYMATQISSAMEYLE---KKNFIHRDLAARNCL 370 Query: 198 LDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVYSY 377 + +N+L K+A G++ G +T I+ T PE + + + KSDV+++ Sbjct: 371 VGENHLVKVADFGLSRLMTG-DTYTAHAGAKFPIKWTA----PESLAYNKFSIKSDVWAF 425 Query: 378 GVLLLELVT 404 GVLL E+ T Sbjct: 426 GVLLWEIAT 434
>YES_HUMAN (P07947) Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2)| (p61-Yes) (c-Yes) Length = 542 Score = 53.9 bits (128), Expect = 2e-07 Identities = 39/129 (30%), Positives = 59/129 (45%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVL 197 V EFM GSL D L L + +A +A+ + Y+ H D++ +N+L Sbjct: 346 VTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERM---NYIHRDLRAANIL 402 Query: 198 LDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVYSY 377 + +N + K+A G+A N I+ T PE + T KSDV+S+ Sbjct: 403 VGENLVCKIADFGLARLIED-NEYTARQGAKFPIKWTA----PEAALYGRFTIKSDVWSF 457 Query: 378 GVLLLELVT 404 G+L ELVT Sbjct: 458 GILQTELVT 466
>RKIN1_SECCE (Q02723) Carbon catabolite derepressing protein kinase (EC| 2.7.11.1) Length = 502 Score = 53.9 bits (128), Expect = 2e-07 Identities = 44/141 (31%), Positives = 69/141 (48%), Gaps = 2/141 (1%) Frame = +3 Query: 12 FQVYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSN 191 F V E+ +NG L D++ +L R + +A+EY H + H D+KP N Sbjct: 91 FVVMEYCQNGDLLDYILEKRRLQEDEARRT--FQQIISAVEYCH---RNKVVHRDLKPEN 145 Query: 192 VLLDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTA--KSD 365 +LLD Y KLA G+++ + G+ + S + Y PE V++ +L A + D Sbjct: 146 LLLDSKYNVKLADFGLSNVMHDGHFLKTSC-------GSLNYAAPE-VISGKLYAGPEID 197 Query: 366 VYSYGVLLLELVTGRPVVQDD 428 V+S GV+L L+ G DD Sbjct: 198 VWSCGVILYALLCGAVPFDDD 218
>ITK_MOUSE (Q03526) Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2)| (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK) Length = 625 Score = 53.9 bits (128), Expect = 2e-07 Identities = 40/140 (28%), Positives = 68/140 (48%), Gaps = 1/140 (0%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVL 197 V+EFME+G L D+L S L + + + +DV + YL C + H D+ N L Sbjct: 439 VFEFMEHGCLSDYLRSQRGLFAA-ETLLGMCLDVCEGMAYLEKAC---VIHRDLAARNCL 494 Query: 198 LDKNYLAKLAGCGIAH-CSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVYS 374 + +N + K++ G+ + T T VK + PE ++KSDV+S Sbjct: 495 VGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVK------WASPEVFSFSRYSSKSDVWS 548 Query: 375 YGVLLLELVTGRPVVQDDRS 434 +GVL+ E+ + + ++RS Sbjct: 549 FGVLMWEVFSEGKIPYENRS 568
>MP2K1_XENLA (Q05116) Dual specificity mitogen-activated protein kinase kinase 1| (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1) Length = 394 Score = 53.9 bits (128), Expect = 2e-07 Identities = 43/143 (30%), Positives = 69/143 (48%), Gaps = 3/143 (2%) Frame = +3 Query: 24 EFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVLLD 203 E M+ GSL L +GK+ P K +++I V L YL + H D+KPSN+L++ Sbjct: 143 EHMDGGSLDQVLKKAGKI--PEKILGKVSIAVIKGLTYLRE--KHKIMHRDVKPSNILVN 198 Query: 204 KNYLAKLAGCGIAH--CSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVYSY 377 KL G++ + N+ VG T Y+ PE + + +SD++S Sbjct: 199 SRGEIKLCDFGVSGQLIDSMANSFVG----------TRSYMSPERLQGTHYSVQSDIWSM 248 Query: 378 GVLLLELVTGR-PVVQDDRSLVE 443 G+ L+E+ GR P+ D +E Sbjct: 249 GLSLVEMAIGRYPIPPPDAKELE 271
>PKPA_PHYBL (Q01577) Serine/threonine-protein kinase pkpA (EC 2.7.11.1)| Length = 613 Score = 53.9 bits (128), Expect = 2e-07 Identities = 39/137 (28%), Positives = 67/137 (48%), Gaps = 7/137 (5%) Frame = +3 Query: 18 VYEFMENGSLKDHLHS-----SGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIK 182 + E M +G+L++++ + K++ W +I L YLH + +PP+ H DIK Sbjct: 90 ITELMTSGTLREYIRKLTPLPNIKIVKRWCRQI------LKGLAYLHGH-EPPIIHRDIK 142 Query: 183 PSNVLLDKNY-LAKLAGCGIAHCSNGGN-TMVGSTPGTVKIQATPGYVDPEYVVTQELTA 356 N+ ++ + K+ G A NG T++G TP ++ PE Q Sbjct: 143 CDNIFINGAHGEIKIGDMGTAEMKNGKKYTVIG----------TPEFMAPEMYEEQGYNE 192 Query: 357 KSDVYSYGVLLLELVTG 407 K D+Y++G+ LLE+ TG Sbjct: 193 KVDIYAFGMCLLEMATG 209
>IPL1_YEAST (P38991) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) (Increase-in-ploidy protein 1) Length = 367 Score = 53.9 bits (128), Expect = 2e-07 Identities = 43/152 (28%), Positives = 69/152 (45%), Gaps = 5/152 (3%) Frame = +3 Query: 12 FQVYEFMENGSLKDHLHSSGKLLLPWKNRI--QIAIDVANALEYLHFYCDPPLYHGDIKP 185 + + E++ NG + L G P+ + + +ANAL+Y+H + H DIKP Sbjct: 178 YLLMEYLVNGEMYKLLRLHG----PFNDILASDYIYQIANALDYMH---KKNIIHRDIKP 230 Query: 186 SNVLLDKNYLAKLAGCG---IAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTA 356 N+L+ N + KL G I N T+ G T Y+ PE V ++E Sbjct: 231 ENILIGFNNVIKLTDFGWSIINPPENRRKTVCG----------TIDYLSPEMVESREYDH 280 Query: 357 KSDVYSYGVLLLELVTGRPVVQDDRSLVEWSR 452 D ++ GVL EL+TG P +++ + R Sbjct: 281 TIDAWALGVLAFELLTGAPPFEEEMKDTTYKR 312
>FYN_HUMAN (P06241) Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2)| (p59-Fyn) (Protooncogene Syn) (SLK) Length = 536 Score = 53.9 bits (128), Expect = 2e-07 Identities = 40/129 (31%), Positives = 58/129 (44%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVL 197 V E+M GSL D L L N + +A VA + Y+ H D++ +N+L Sbjct: 340 VTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERM---NYIHRDLRSANIL 396 Query: 198 LDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVYSY 377 + + K+A G+A N I+ T PE + T KSDV+S+ Sbjct: 397 VGNGLICKIADFGLARLIED-NEYTARQGAKFPIKWTA----PEAALYGRFTIKSDVWSF 451 Query: 378 GVLLLELVT 404 G+LL ELVT Sbjct: 452 GILLTELVT 460
>M3KSL_DROME (Q95UN8) Mitogen-activated protein kinase kinase kinase (EC| 2.7.11.25) (Mixed lineage kinase) (dMLK) (Protein slipper) Length = 1161 Score = 53.9 bits (128), Expect = 2e-07 Identities = 47/138 (34%), Positives = 66/138 (47%), Gaps = 8/138 (5%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVL 197 V E+ GSL L +GK+ P + AI +A + YLH + H D+K SNVL Sbjct: 216 VMEYARGGSLNRIL--AGKI--PPDVLVNWAIQIARGMNYLHNEAPMSIIHRDLKSSNVL 271 Query: 198 L----DKNYLA----KLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELT 353 + + N+L K+ G+A NT S GT ++ PE + + Sbjct: 272 IYEAIEGNHLQQKTLKITDFGLAR--EMYNTQRMSAAGTY------AWMPPEVISVSTYS 323 Query: 354 AKSDVYSYGVLLLELVTG 407 SDV+SYGVLL EL+TG Sbjct: 324 KFSDVWSYGVLLWELITG 341
>BRSK1_HUMAN (Q8TDC3) BR serine/threonine-protein kinase 1 (EC 2.7.11.1) (SAD1| kinase) (SAD1A) Length = 794 Score = 53.9 bits (128), Expect = 2e-07 Identities = 42/147 (28%), Positives = 71/147 (48%), Gaps = 3/147 (2%) Frame = +3 Query: 12 FQVYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSN 191 + V E + G L D+L G+L K + + +AL++ H Y + H D+KP N Sbjct: 123 YLVLEHVSGGELFDYLVKKGRLTP--KEARKFFRQIVSALDFCHSYS---ICHRDLKPEN 177 Query: 192 VLLDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTA-KSDV 368 +LLD+ ++A G+A G + + S +P Y PE + ++ ++D+ Sbjct: 178 LLLDEKNNIRIADFGMASLQVGDSLLETSC-------GSPHYACPEVIKGEKYDGRRADM 230 Query: 369 YSYGVLLLELVTGRPVVQDD--RSLVE 443 +S GV+L L+ G DD R L+E Sbjct: 231 WSCGVILFALLVGALPFDDDNLRQLLE 257
>LYN_HUMAN (P07948) Tyrosine-protein kinase Lyn (EC 2.7.10.2)| Length = 511 Score = 53.9 bits (128), Expect = 2e-07 Identities = 42/131 (32%), Positives = 64/131 (48%), Gaps = 2/131 (1%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSS--GKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSN 191 + E+M GSL D L S GK+LLP I + +A + Y+ H D++ +N Sbjct: 317 ITEYMAKGSLLDFLKSDEGGKVLLP--KLIDFSAQIAEGMAYIE---RKNYIHRDLRAAN 371 Query: 192 VLLDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVY 371 VL+ ++ + K+A G+A N I+ T PE + T KSDV+ Sbjct: 372 VLVSESLMCKIADFGLARVIED-NEYTAREGAKFPIKWTA----PEAINFGCFTIKSDVW 426 Query: 372 SYGVLLLELVT 404 S+G+LL E+VT Sbjct: 427 SFGILLYEIVT 437
>KPCD_HUMAN (Q05655) Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta)| Length = 676 Score = 53.9 bits (128), Expect = 2e-07 Identities = 40/139 (28%), Positives = 65/139 (46%) Frame = +3 Query: 12 FQVYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSN 191 F V EF+ G L H+ G+ L A ++ L++LH + + D+K N Sbjct: 424 FFVMEFLNGGDLMYHIQDKGRFEL--YRATFYAAEIMCGLQFLH---SKGIIYRDLKLDN 478 Query: 192 VLLDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVY 371 VLLD++ K+A G+ + G + + GT P Y+ PE + + T D + Sbjct: 479 VLLDRDGHIKIADFGMCKENIFGESRASTFCGT------PDYIAPEILQGLKYTFSVDWW 532 Query: 372 SYGVLLLELVTGRPVVQDD 428 S+GVLL E++ G+ D Sbjct: 533 SFGVLLYEMLIGQSPFHGD 551
>M3K9_HUMAN (P80192) Mitogen-activated protein kinase kinase kinase 9 (EC| 2.7.11.25) (Mixed lineage kinase 1) Length = 1104 Score = 53.9 bits (128), Expect = 2e-07 Identities = 45/138 (32%), Positives = 64/138 (46%), Gaps = 8/138 (5%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVL 197 V EF G L L SGK + P + A+ +A + YLH P+ H D+K SN+L Sbjct: 219 VMEFARGGPLNRVL--SGKRIPP-DILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNIL 275 Query: 198 LDK--------NYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELT 353 + + N + K+ G+A T S GT ++ PE + + Sbjct: 276 ILQKVENGDLSNKILKITDFGLAR--EWHRTTKMSAAGTY------AWMAPEVIRASMFS 327 Query: 354 AKSDVYSYGVLLLELVTG 407 SDV+SYGVLL EL+TG Sbjct: 328 KGSDVWSYGVLLWELLTG 345
>ABL_MLVAB (P00521) Tyrosine-protein kinase transforming protein Abl (EC| 2.7.10.2) (V-abl) Length = 746 Score = 53.9 bits (128), Expect = 2e-07 Identities = 37/129 (28%), Positives = 64/129 (49%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVL 197 + EFM G+L D+L + + + +A +++A+EYL H D+ N L Sbjct: 200 ITEFMTYGNLLDYLRECNRQEVSAVVLLYMATQISSAMEYLE---KKNFIHRDLAARNCL 256 Query: 198 LDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVYSY 377 + +N+L K+A G++ G +T I+ T PE + + + KSDV+++ Sbjct: 257 VGENHLVKVADFGLSRLMTG-DTYTAHAGAKFPIKWTA----PESLAYNKFSIKSDVWAF 311 Query: 378 GVLLLELVT 404 GVLL E+ T Sbjct: 312 GVLLWEIAT 320
>FYN_MOUSE (P39688) Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2)| (p59-Fyn) Length = 533 Score = 53.9 bits (128), Expect = 2e-07 Identities = 40/129 (31%), Positives = 58/129 (44%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVL 197 V E+M GSL D L L N + +A VA + Y+ H D++ +N+L Sbjct: 337 VTEYMSKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERM---NYIHRDLRSANIL 393 Query: 198 LDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVYSY 377 + + K+A G+A N I+ T PE + T KSDV+S+ Sbjct: 394 VGNGLICKIADFGLARLIED-NEYTARQGAKFPIKWTA----PEAALYGRFTIKSDVWSF 448 Query: 378 GVLLLELVT 404 G+LL ELVT Sbjct: 449 GILLTELVT 457
>TESK1_HUMAN (Q15569) Dual specificity testis-specific protein kinase 1 (EC| 2.7.12.1) (Testicular protein kinase 1) Length = 626 Score = 53.5 bits (127), Expect = 3e-07 Identities = 37/137 (27%), Positives = 67/137 (48%), Gaps = 3/137 (2%) Frame = +3 Query: 24 EFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVLL- 200 E+M G+L+ L S L W R+ +A+D+A L YLH ++H D+ N L+ Sbjct: 130 EYMNGGTLEQLLSSPEPL--SWPVRLHLALDIARGLRYLH---SKGVFHRDLTSKNCLVR 184 Query: 201 --DKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVYS 374 D+ + A + G+A G+ + + +P ++ PE + + K+DV++ Sbjct: 185 REDRGFTAVVGDFGLAEKIPVYRE--GARKEPLAVVGSPYWMAPEVLRGELYDEKADVFA 242 Query: 375 YGVLLLELVTGRPVVQD 425 +G++L EL+ P D Sbjct: 243 FGIVLCELIARVPADPD 259
>RAF1_RAT (P11345) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 53.5 bits (127), Expect = 3e-07 Identities = 42/135 (31%), Positives = 65/135 (48%), Gaps = 5/135 (3%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVL 197 V ++ E SL HLH ++ I IA A ++YLH + H D+K +N+ Sbjct: 420 VTQWCEGSSLYKHLHVQETKFQMFQ-LIDIARQTAQGMDYLHA---KNIIHRDMKSNNIF 475 Query: 198 LDKNYLAKLAGCGIAHCSN--GGNTMVGSTPGTVKIQATPGYVDPEYVVTQE---LTAKS 362 L + K+ G+A + G+ V G+V A PE + Q+ + +S Sbjct: 476 LHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMA------PEVIRMQDNNPFSFQS 529 Query: 363 DVYSYGVLLLELVTG 407 DVYSYG++L EL+TG Sbjct: 530 DVYSYGIVLYELMTG 544
>RAF1_HUMAN (P04049) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 53.5 bits (127), Expect = 3e-07 Identities = 42/135 (31%), Positives = 65/135 (48%), Gaps = 5/135 (3%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVL 197 V ++ E SL HLH ++ I IA A ++YLH + H D+K +N+ Sbjct: 420 VTQWCEGSSLYKHLHVQETKFQMFQ-LIDIARQTAQGMDYLHA---KNIIHRDMKSNNIF 475 Query: 198 LDKNYLAKLAGCGIAHCSN--GGNTMVGSTPGTVKIQATPGYVDPEYVVTQE---LTAKS 362 L + K+ G+A + G+ V G+V A PE + Q+ + +S Sbjct: 476 LHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMA------PEVIRMQDNNPFSFQS 529 Query: 363 DVYSYGVLLLELVTG 407 DVYSYG++L EL+TG Sbjct: 530 DVYSYGIVLYELMTG 544
>BRSK2_HUMAN (Q8IWQ3) BR serine/threonine-protein kinase 2 (EC 2.7.11.1)| (Serine/threonine-protein kinase 29) (SAD1B) Length = 736 Score = 53.5 bits (127), Expect = 3e-07 Identities = 43/147 (29%), Positives = 71/147 (48%), Gaps = 3/147 (2%) Frame = +3 Query: 12 FQVYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSN 191 + V E + G L D+L G+L K + + +AL++ H + + H D+KP N Sbjct: 92 YLVLEHVSGGELFDYLVKKGRLTP--KEARKFFRQIISALDFCHSHS---ICHRDLKPEN 146 Query: 192 VLLDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTA-KSDV 368 +LLD+ ++A G+A G + + S +P Y PE + ++ K+DV Sbjct: 147 LLLDEKNNIRIADFGMASLQVGDSLLETSC-------GSPHYACPEVIRGEKYDGRKADV 199 Query: 369 YSYGVLLLELVTGRPVVQDD--RSLVE 443 +S GV+L L+ G DD R L+E Sbjct: 200 WSCGVILFALLVGALPFDDDNLRQLLE 226
>PKNA_MYCLE (P54743) Probable serine/threonine-protein kinase pknA (EC| 2.7.11.1) Length = 437 Score = 53.5 bits (127), Expect = 3e-07 Identities = 41/143 (28%), Positives = 64/143 (44%), Gaps = 1/143 (0%) Frame = +3 Query: 12 FQVYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSN 191 + V E + L L +G+L L ++ + + AL+ H L H D+KP N Sbjct: 92 YLVMELVNGEPLNSVLKRTGRLSL--RHALDMLEQTGRALQIAHA---AGLVHRDVKPGN 146 Query: 192 VLLDKNYLAKLAGCGIAHCSNGGN-TMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDV 368 +L+ K+ GIA + T G GT + Y+ PE + + T SDV Sbjct: 147 ILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQ------YIAPEQALGHDATPASDV 200 Query: 369 YSYGVLLLELVTGRPVVQDDRSL 437 YS GV+ E+V+G+ D +L Sbjct: 201 YSLGVIGYEVVSGKRPFTGDGAL 223
>ABL1_HUMAN (P00519) Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2)| (p150) (c-ABL) (Abelson murine leukemia viral oncogene homolog 1) Length = 1130 Score = 53.5 bits (127), Expect = 3e-07 Identities = 37/129 (28%), Positives = 64/129 (49%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVL 197 + EFM G+L D+L + + + +A +++A+EYL H D+ N L Sbjct: 314 ITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLE---KKNFIHRDLAARNCL 370 Query: 198 LDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVYSY 377 + +N+L K+A G++ G +T I+ T PE + + + KSDV+++ Sbjct: 371 VGENHLVKVADFGLSRLMTG-DTYTAHAGAKFPIKWTA----PESLAYNKFSIKSDVWAF 425 Query: 378 GVLLLELVT 404 GVLL E+ T Sbjct: 426 GVLLWEIAT 434
>TNI3K_MOUSE (Q5GIG6) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 833 Score = 53.1 bits (126), Expect = 3e-07 Identities = 43/133 (32%), Positives = 70/133 (52%), Gaps = 3/133 (2%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVL 197 V +++ GSL LH K +L ++++ IA+DVA +EYLH P+ H D+ N+L Sbjct: 536 VTQYISGGSLFSLLHEQ-KRILDLQSKLIIAVDVAKGMEYLHSLTQ-PIIHRDLNSHNIL 593 Query: 198 LDKNYLAKLAGCGIAH-CSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQ--ELTAKSDV 368 L ++ A +A G + + + PG ++ ++ PE V TQ T K+DV Sbjct: 594 LYEDGHAVVADFGESRFLQSLDEDNMTKQPGNLR------WMAPE-VFTQCTRYTIKADV 646 Query: 369 YSYGVLLLELVTG 407 +SY + L EL+ G Sbjct: 647 FSYALCLWELLIG 659
>AAPK2_PONPY (Q5RD00) 5'-AMP-activated protein kinase catalytic subunit alpha-2| (EC 2.7.11.1) (AMPK alpha-2 chain) Length = 552 Score = 53.1 bits (126), Expect = 3e-07 Identities = 41/141 (29%), Positives = 71/141 (50%), Gaps = 2/141 (1%) Frame = +3 Query: 12 FQVYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSN 191 F V E++ G L D++ G++ R+ + +A++Y H + + H D+KP N Sbjct: 90 FMVMEYVSGGELFDYICKHGRVEEMEARRL--FQQILSAVDYCHRHM---VVHRDLKPEN 144 Query: 192 VLLDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTA--KSD 365 VLLD + AK+A G+++ + G + S +P Y PE V++ L A + D Sbjct: 145 VLLDAHMNAKIADFGLSNIMSDGEFLRTSC-------GSPNYAAPE-VISGRLYAGPEVD 196 Query: 366 VYSYGVLLLELVTGRPVVQDD 428 ++S GV+L L+ G D+ Sbjct: 197 IWSCGVILYALLCGTLPFDDE 217
>AAPK2_HUMAN (P54646) 5'-AMP-activated protein kinase catalytic subunit alpha-2| (EC 2.7.11.1) (AMPK alpha-2 chain) Length = 552 Score = 53.1 bits (126), Expect = 3e-07 Identities = 41/141 (29%), Positives = 71/141 (50%), Gaps = 2/141 (1%) Frame = +3 Query: 12 FQVYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSN 191 F V E++ G L D++ G++ R+ + +A++Y H + + H D+KP N Sbjct: 90 FMVMEYVSGGELFDYICKHGRVEEMEARRL--FQQILSAVDYCHRHM---VVHRDLKPEN 144 Query: 192 VLLDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTA--KSD 365 VLLD + AK+A G+++ + G + S +P Y PE V++ L A + D Sbjct: 145 VLLDAHMNAKIADFGLSNMMSDGEFLRTSC-------GSPNYAAPE-VISGRLYAGPEVD 196 Query: 366 VYSYGVLLLELVTGRPVVQDD 428 ++S GV+L L+ G D+ Sbjct: 197 IWSCGVILYALLCGTLPFDDE 217
>RAF1_CHICK (P05625) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (RAF-1) (C-RAF) (MIL proto-oncogene serine/threonine-protein kinase) (C-MIL) Length = 647 Score = 53.1 bits (126), Expect = 3e-07 Identities = 41/135 (30%), Positives = 65/135 (48%), Gaps = 5/135 (3%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVL 197 V ++ E SL HLH ++ I IA A ++YLH + H D+K +N+ Sbjct: 420 VTQWCEGSSLYKHLHVQETKFQMFQ-LIDIARQTAQGMDYLHA---KNIIHRDMKSNNIF 475 Query: 198 LDKNYLAKLAGCGIAHCSN--GGNTMVGSTPGTVKIQATPGYVDPEYVVTQE---LTAKS 362 L + K+ G+A + G+ V G++ A PE + Q+ + +S Sbjct: 476 LHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSILWMA------PEVIRMQDSNPFSFQS 529 Query: 363 DVYSYGVLLLELVTG 407 DVYSYG++L EL+TG Sbjct: 530 DVYSYGIVLYELMTG 544
>KPCE_MOUSE (P16054) Protein kinase C epsilon type (EC 2.7.11.13)| (nPKC-epsilon) Length = 737 Score = 53.1 bits (126), Expect = 3e-07 Identities = 45/139 (32%), Positives = 68/139 (48%) Frame = +3 Query: 12 FQVYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSN 191 F V E++ G L + S K P ++R A +V +AL +LH + + + D+K N Sbjct: 483 FFVMEYVNGGDLMFQIQRSRKFDEP-RSRFYAA-EVTSALMFLHQH---GVIYRDLKLDN 537 Query: 192 VLLDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVY 371 +LLD KLA G+ C G M G T T TP Y+ PE + E D + Sbjct: 538 ILLDAEGHCKLADFGM--CKEG--IMNGVT--TTTFCGTPDYIAPEILQELEYGPSVDWW 591 Query: 372 SYGVLLLELVTGRPVVQDD 428 + GVL+ E++ G+P + D Sbjct: 592 ALGVLMYEMMAGQPPFEAD 610
>NEK7_HUMAN (Q8TDX7) Serine/threonine-protein kinase Nek7 (EC 2.7.11.1)| (NimA-related protein kinase 7) Length = 302 Score = 53.1 bits (126), Expect = 3e-07 Identities = 38/135 (28%), Positives = 61/135 (45%), Gaps = 1/135 (0%) Frame = +3 Query: 72 KLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVLLDKNYLAKLAGCGIAHCS 251 K L+P + + + + +ALE++H + H DIKP+NV + + KL G+ Sbjct: 130 KRLIPERTVWKYFVQLCSALEHMH---SRRVMHRDIKPANVFITATGVVKLGDLGLGRFF 186 Query: 252 NGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVYSYGVLLLELVT-GRPVVQDD 428 + T S GT P Y+ PE + KSD++S G LL E+ P D Sbjct: 187 SSKTTAAHSLVGT------PYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDK 240 Query: 429 RSLVEWSRELIGTDY 473 +L +++ DY Sbjct: 241 MNLYSLCKKIEQCDY 255
>SRK2_SPOLA (P42688) Tyrosine-protein kinase SRK2 (EC 2.7.10.2) (Fragment)| Length = 362 Score = 53.1 bits (126), Expect = 3e-07 Identities = 42/132 (31%), Positives = 64/132 (48%), Gaps = 3/132 (2%) Frame = +3 Query: 18 VYEFMENGSLKDHLHS-SGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNV 194 + E M GSL D+L +G L LP I +A VA + YL + H D+ N+ Sbjct: 166 ITELMSKGSLLDYLQGEAGALKLP--QLIDMAAQVAAGMAYLELH---NYIHRDLAARNI 220 Query: 195 LLDKNYLAKLAGCGIAHC--SNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDV 368 L+ N + K+A G+A S+ N G+ + + PE + + KSDV Sbjct: 221 LVGDNNICKVADFGLARLIVSDDYNATEGA-------KFPIKWTAPEAALFNRFSIKSDV 273 Query: 369 YSYGVLLLELVT 404 +S+G+L+ ELVT Sbjct: 274 WSFGILITELVT 285
>SRC_RSVPA (P31693) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 522 Score = 53.1 bits (126), Expect = 3e-07 Identities = 37/129 (28%), Positives = 61/129 (47%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVL 197 V E+M GSL D L L +++A +A+ + Y+ H D++ +N+L Sbjct: 333 VIEYMSKGSLLDFLKGEMGKYLRLPQLVEMAAQIASGMAYVERM---NYVHRDLRAANIL 389 Query: 198 LDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVYSY 377 + +N + K+A G+A + PG + + PE + T KSDV+S+ Sbjct: 390 VGENLVCKVADFGLARLIEDNEYT--ARPGA---RFPVKWTAPEAALYGRFTIKSDVWSF 444 Query: 378 GVLLLELVT 404 G+LL EL T Sbjct: 445 GILLTELTT 453
>KOK0_YEAST (Q12236) Probable serine/threonine-protein kinase YOL100W (EC| 2.7.11.1) Length = 1081 Score = 53.1 bits (126), Expect = 3e-07 Identities = 31/107 (28%), Positives = 51/107 (47%), Gaps = 5/107 (4%) Frame = +3 Query: 108 AIDVANALEYLHFYCDPPLYHGDIKPSNVLLDKNYLAKLAGCGIAHCSNGGNTMVGSTPG 287 A + +A++YLH + H DIKP N+LLD KL G A N N V Sbjct: 284 AAQIIDAIDYLH---SNGIIHRDIKPENILLDGEMKIKLTDFGTAKLLNPTNNSVSKPEY 340 Query: 288 TVKIQA-----TPGYVDPEYVVTQELTAKSDVYSYGVLLLELVTGRP 413 + ++ T YV PE + + D++++G +L +++ G+P Sbjct: 341 DLSTRSKSFVGTAEYVSPELLNDSFTDYRCDIWAFGCILFQMIAGKP 387
>HCK_MOUSE (P08103) Tyrosine-protein kinase HCK (EC 2.7.10.2)| (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK) Length = 523 Score = 52.8 bits (125), Expect = 5e-07 Identities = 38/131 (29%), Positives = 60/131 (45%) Frame = +3 Query: 12 FQVYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSN 191 F V EFM GSL D L S P I + ++ + ++ H D++ +N Sbjct: 327 FIVTEFMAKGSLLDFLKSEEGSKQPLPKLIDFSAQISEGMAFIE---QRNYIHRDLRAAN 383 Query: 192 VLLDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVY 371 +L+ + + K+A G+A N I+ T PE + T KSDV+ Sbjct: 384 ILVSASLVCKIADFGLARIIED-NEYTAREGAKFPIKWTA----PEAINFGSFTIKSDVW 438 Query: 372 SYGVLLLELVT 404 S+G+LL+E+VT Sbjct: 439 SFGILLMEIVT 449
>ITK_HUMAN (Q08881) Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2)| (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT) Length = 620 Score = 52.8 bits (125), Expect = 5e-07 Identities = 39/140 (27%), Positives = 68/140 (48%), Gaps = 1/140 (0%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVL 197 V+EFME+G L D+L + L + + + +DV + YL C + H D+ N L Sbjct: 434 VFEFMEHGCLSDYLRTQRGLFAA-ETLLGMCLDVCEGMAYLEEAC---VIHRDLAARNCL 489 Query: 198 LDKNYLAKLAGCGIAH-CSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVYS 374 + +N + K++ G+ + T T VK + PE ++KSDV+S Sbjct: 490 VGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVK------WASPEVFSFSRYSSKSDVWS 543 Query: 375 YGVLLLELVTGRPVVQDDRS 434 +GVL+ E+ + + ++RS Sbjct: 544 FGVLMWEVFSEGKIPYENRS 563
>AAPK2_RAT (Q09137) 5'-AMP-activated protein kinase catalytic subunit alpha-2| (EC 2.7.11.1) (AMPK alpha-2 chain) Length = 552 Score = 52.8 bits (125), Expect = 5e-07 Identities = 41/141 (29%), Positives = 70/141 (49%), Gaps = 2/141 (1%) Frame = +3 Query: 12 FQVYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSN 191 F V E++ G L D++ G++ R+ + +A++Y H + + H D+KP N Sbjct: 90 FMVMEYVSGGELFDYICKHGRVEEVEARRL--FQQILSAVDYCHRHM---VVHRDLKPEN 144 Query: 192 VLLDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTA--KSD 365 VLLD AK+A G+++ + G + S +P Y PE V++ L A + D Sbjct: 145 VLLDAQMNAKIADFGLSNMMSDGEFLRTSC-------GSPNYAAPE-VISGRLYAGPEVD 196 Query: 366 VYSYGVLLLELVTGRPVVQDD 428 ++S GV+L L+ G D+ Sbjct: 197 IWSCGVILYALLCGTLPFDDE 217
>AAPK2_PIG (Q28948) 5'-AMP-activated protein kinase catalytic subunit alpha-2| (EC 2.7.11.1) (AMPK alpha-2 chain) Length = 552 Score = 52.8 bits (125), Expect = 5e-07 Identities = 41/141 (29%), Positives = 70/141 (49%), Gaps = 2/141 (1%) Frame = +3 Query: 12 FQVYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSN 191 F V E++ G L D++ G++ R+ + +A++Y H + + H D+KP N Sbjct: 90 FMVMEYVSGGELFDYICKHGRVEEMEARRL--FQQILSAVDYCHRHM---VVHRDLKPEN 144 Query: 192 VLLDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTA--KSD 365 VLLD AK+A G+++ + G + S +P Y PE V++ L A + D Sbjct: 145 VLLDAQMNAKIADFGLSNMMSDGEFLRTSC-------GSPNYAAPE-VISGRLYAGPEVD 196 Query: 366 VYSYGVLLLELVTGRPVVQDD 428 ++S GV+L L+ G D+ Sbjct: 197 IWSCGVILYALLCGTLPFDDE 217
>NRKA_TRYBB (Q08942) Putative serine/threonine-protein kinase A (EC 2.7.11.1)| Length = 431 Score = 52.8 bits (125), Expect = 5e-07 Identities = 40/131 (30%), Positives = 63/131 (48%), Gaps = 3/131 (2%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGK---LLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPS 188 V EF ++G+L + + G + + + + AL+Y+H + + H DIK + Sbjct: 95 VMEFADSGNLDEQIKLRGSGDARYFQEHEALFLFLQLCLALDYIHSH---KMLHRDIKSA 151 Query: 189 NVLLDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDV 368 NVLL L KL G +H +T+ G T TP Y+ PE + K+DV Sbjct: 152 NVLLTSTGLVKLGDFGFSHQYE--DTVSGVVAST--FCGTPYYLAPELWNNKRYNKKADV 207 Query: 369 YSYGVLLLELV 401 +S GVLL E++ Sbjct: 208 WSLGVLLYEIM 218
>KPCI_MOUSE (Q62074) Protein kinase C iota type (EC 2.7.11.13) (nPKC-iota)| (Atypical protein kinase C-lambda/iota) (aPKC-lambda/iota) Length = 586 Score = 52.8 bits (125), Expect = 5e-07 Identities = 41/133 (30%), Positives = 64/133 (48%) Frame = +3 Query: 12 FQVYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSN 191 F V E++ G L H+ KL P ++ + +++ AL YLH + + + D+K N Sbjct: 319 FFVIEYVNGGDLMFHMQRQRKL--PEEHARFYSAEISLALNYLH---ERGIIYRDLKLDN 373 Query: 192 VLLDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVY 371 VLLD KL G+ C G G T T TP Y+ PE + ++ D + Sbjct: 374 VLLDSEGHIKLTDYGM--CKEG--LRPGDTTST--FCGTPNYIAPEILRGEDYGFSVDWW 427 Query: 372 SYGVLLLELVTGR 410 + GVL+ E++ GR Sbjct: 428 ALGVLMFEMMAGR 440
>KGP2_MOUSE (Q61410) cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2)| (cGKII) (Type II cGMP-dependent protein kinase) Length = 762 Score = 52.8 bits (125), Expect = 5e-07 Identities = 33/99 (33%), Positives = 48/99 (48%) Frame = +3 Query: 117 VANALEYLHFYCDPPLYHGDIKPSNVLLDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVK 296 V A +YLH + + D+KP N++LD + KL G A +GS T Sbjct: 560 VTEAFDYLHLL---GIIYRDLKPENLILDADGYLKLVDFGFAK-------KIGSGQKTWT 609 Query: 297 IQATPGYVDPEYVVTQELTAKSDVYSYGVLLLELVTGRP 413 TP YV PE ++ + D +S G+L+ EL+TG P Sbjct: 610 FCGTPEYVAPEVILNKGHDFSVDFWSLGILVYELLTGNP 648
>DCAK2_HUMAN (Q8N568) Serine/threonine-protein kinase DCAMKL2 (EC 2.7.11.1)| (Doublecortin-like and CAM kinase-like 2) Length = 766 Score = 52.8 bits (125), Expect = 5e-07 Identities = 45/150 (30%), Positives = 67/150 (44%), Gaps = 4/150 (2%) Frame = +3 Query: 6 ERFQVYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKP 185 E F V E ++ G L D + SS K ++ + ++ANAL YLH + H DIKP Sbjct: 464 ELFLVMELVKGGDLFDAITSSTKYTE--RDGSAMVYNLANALRYLHGLS---IVHRDIKP 518 Query: 186 SNVLL----DKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELT 353 N+L+ D KL G+A G + TP YV PE + Sbjct: 519 ENLLVCEYPDGTKSLKLGDFGLATVVEGP---------LYTVCGTPTYVAPEIIAETGYG 569 Query: 354 AKSDVYSYGVLLLELVTGRPVVQDDRSLVE 443 K D+++ GV+ L+ G P + + +L E Sbjct: 570 LKVDIWAAGVITYILLCGFPPFRSENNLQE 599
>KPCI_PONPY (Q5R4K9) Protein kinase C iota type (EC 2.7.11.13) (nPKC-iota)| Length = 587 Score = 52.8 bits (125), Expect = 5e-07 Identities = 41/133 (30%), Positives = 64/133 (48%) Frame = +3 Query: 12 FQVYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSN 191 F V E++ G L H+ KL P ++ + +++ AL YLH + + + D+K N Sbjct: 320 FFVIEYVNGGDLMFHMQRQRKL--PEEHARFYSAEISLALNYLH---ERGIIYRDLKLDN 374 Query: 192 VLLDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVY 371 VLLD KL G+ C G G T T TP Y+ PE + ++ D + Sbjct: 375 VLLDSEGHIKLTDYGM--CKEG--LRPGDTTST--FCGTPNYIAPEILRGEDYGFSVDWW 428 Query: 372 SYGVLLLELVTGR 410 + GVL+ E++ GR Sbjct: 429 ALGVLMFEMMAGR 441
>KPCI_HUMAN (P41743) Protein kinase C iota type (EC 2.7.11.13) (nPKC-iota)| (Atypical protein kinase C-lambda/iota) (aPKC-lambda/iota) (PRKC-lambda/iota) Length = 587 Score = 52.8 bits (125), Expect = 5e-07 Identities = 41/133 (30%), Positives = 64/133 (48%) Frame = +3 Query: 12 FQVYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSN 191 F V E++ G L H+ KL P ++ + +++ AL YLH + + + D+K N Sbjct: 320 FFVIEYVNGGDLMFHMQRQRKL--PEEHARFYSAEISLALNYLH---ERGIIYRDLKLDN 374 Query: 192 VLLDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVY 371 VLLD KL G+ C G G T T TP Y+ PE + ++ D + Sbjct: 375 VLLDSEGHIKLTDYGM--CKEG--LRPGDTTST--FCGTPNYIAPEILRGEDYGFSVDWW 428 Query: 372 SYGVLLLELVTGR 410 + GVL+ E++ GR Sbjct: 429 ALGVLMFEMMAGR 441
>LCK_SAISC (Q95KR7) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) Length = 508 Score = 52.8 bits (125), Expect = 5e-07 Identities = 36/129 (27%), Positives = 60/129 (46%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVL 197 + E+MENGSL D L + + L + +A + + +L + H D++ +N+L Sbjct: 314 ITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIVEGMAFLE---ERNYIHRDLRAANIL 370 Query: 198 LDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVYSY 377 + K+A G+A N I+ T PE + T KSDV+S+ Sbjct: 371 VSDTLSCKIADFGLARLIED-NEYTAREGAKFPIKWTA----PEAINYGTFTIKSDVWSF 425 Query: 378 GVLLLELVT 404 G+L+ E+VT Sbjct: 426 GILMTEIVT 434
>GIN4_YEAST (Q12263) Serine/threonine-protein kinase GIN4 (EC 2.7.11.1)| Length = 1142 Score = 52.8 bits (125), Expect = 5e-07 Identities = 45/144 (31%), Positives = 65/144 (45%), Gaps = 2/144 (1%) Frame = +3 Query: 12 FQVYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSN 191 + V E+ E G L + L G L P I+ + + Y H + H D+KP N Sbjct: 107 YLVLEYAEKGELFNLLVERGPL--PEHEAIRFFRQIIIGVSYCHAL---GIVHRDLKPEN 161 Query: 192 VLLDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTA-KSDV 368 +LLD Y K+A G+A G + S +P Y PE V SDV Sbjct: 162 LLLDHKYNIKIADFGMAALETEGKLLETSC-------GSPHYAAPEIVSGIPYQGFASDV 214 Query: 369 YSYGVLLLELVTGR-PVVQDDRSL 437 +S GV+L L+TGR P ++D ++ Sbjct: 215 WSCGVILFALLTGRLPFDEEDGNI 238
>KPC1_APLCA (Q16974) Calcium-dependent protein kinase C (EC 2.7.11.13) (APL I)| Length = 649 Score = 52.8 bits (125), Expect = 5e-07 Identities = 43/132 (32%), Positives = 61/132 (46%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVL 197 V E++ G L + GK P A ++A L YLH + + D+K NV+ Sbjct: 397 VMEYVNGGDLMYRIQQEGKFKEPVA--AFYAAEIAIGLFYLH---TQGIVYRDLKLDNVM 451 Query: 198 LDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVYSY 377 LD K+A G+ C N M T T TP Y+ PE V+ Q D ++Y Sbjct: 452 LDAEGHIKIADFGM--CKE--NIMGDKTTRT--FCGTPDYIAPEIVLYQPYGRSVDWWAY 505 Query: 378 GVLLLELVTGRP 413 GVLL E++ G+P Sbjct: 506 GVLLYEMLAGQP 517
>KPCT_MOUSE (Q02111) Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta)| Length = 707 Score = 52.8 bits (125), Expect = 5e-07 Identities = 38/133 (28%), Positives = 65/133 (48%) Frame = +3 Query: 12 FQVYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSN 191 F V E++ G L H+ S K L A +V L++LH + + D+K N Sbjct: 455 FFVMEYLNGGDLMYHIQSCHKFDL--SRATFYAAEVILGLQFLH---SKGIVYRDLKLDN 509 Query: 192 VLLDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVY 371 +LLD++ K+A G+ + G+ + GT P Y+ PE ++ Q+ D + Sbjct: 510 ILLDRDGHIKIADFGMCKENMLGDAKTNTFCGT------PDYIAPEILLGQKYNHSVDWW 563 Query: 372 SYGVLLLELVTGR 410 S+GVL+ E++ G+ Sbjct: 564 SFGVLVYEMLIGQ 576
>HCK_RAT (P50545) Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK)| (Hemopoietic cell kinase) Length = 502 Score = 52.8 bits (125), Expect = 5e-07 Identities = 38/131 (29%), Positives = 60/131 (45%) Frame = +3 Query: 12 FQVYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSN 191 F V EFM GSL D L S P I + ++ + ++ H D++ +N Sbjct: 306 FIVTEFMAKGSLLDFLKSEEGSKQPLPKLIDFSAQISEGMAFIE---QRNYIHRDLRAAN 362 Query: 192 VLLDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVY 371 +L+ + + K+A G+A N I+ T PE + T KSDV+ Sbjct: 363 ILVSASLVCKIADFGLARIIED-NEYTAREGAKFPIKWTA----PEAINFGSFTIKSDVW 417 Query: 372 SYGVLLLELVT 404 S+G+LL+E+VT Sbjct: 418 SFGILLMEIVT 428
>KPCA_MOUSE (P20444) Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha)| (PKC-A) Length = 671 Score = 52.8 bits (125), Expect = 5e-07 Identities = 40/132 (30%), Positives = 64/132 (48%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVL 197 V E++ G L H+ GK P + A +++ L +LH + + D+K +NV+ Sbjct: 415 VMEYVNGGDLMYHIQQVGKFKEP--QAVFYAAEISIGLFFLH---KRGIIYRDLKLNNVM 469 Query: 198 LDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVYSY 377 L+ K+A G+ C + M G T T TP Y+ PE + Q D ++Y Sbjct: 470 LNSEGHIKIADFGM--CKE--HMMDGVTTRT--FCGTPDYIAPEIIAYQPYGKSVDWWAY 523 Query: 378 GVLLLELVTGRP 413 GVLL E++ G+P Sbjct: 524 GVLLYEMLAGQP 535
>TESK1_MOUSE (O70146) Dual specificity testis-specific protein kinase 1 (EC| 2.7.12.1) (Testicular protein kinase 1) Length = 627 Score = 52.8 bits (125), Expect = 5e-07 Identities = 37/137 (27%), Positives = 67/137 (48%), Gaps = 3/137 (2%) Frame = +3 Query: 24 EFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVLL- 200 E+M G+L+ L S L W R+ +A+D+A L YLH ++H D+ N L+ Sbjct: 125 EYMNGGTLEQLLSSPEPL--SWPVRLHLALDIAQGLRYLHA---KGVFHRDLTSKNCLVR 179 Query: 201 --DKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVYS 374 D+ + A + G+A G+ + + +P ++ PE + + K+DV++ Sbjct: 180 REDRGFTAVVGDFGLAEKIPVYRE--GTRKEPLAVVGSPYWMAPEVLRGELYDEKADVFA 237 Query: 375 YGVLLLELVTGRPVVQD 425 +G++L EL+ P D Sbjct: 238 FGIVLCELIARVPADPD 254
>M3K13_PONPY (Q5R8X7) Mitogen-activated protein kinase kinase kinase 13 (EC| 2.7.11.25) Length = 966 Score = 52.8 bits (125), Expect = 5e-07 Identities = 42/148 (28%), Positives = 72/148 (48%), Gaps = 5/148 (3%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGK----LLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKP 185 + E+ +G L + L + K LL+ W I A+ + YLH + + H D+K Sbjct: 232 IMEYCAHGQLYEVLRAGRKITPRLLVDWSTGI------ASGMNYLHLH---KIIHRDLKS 282 Query: 186 SNVLLDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSD 365 NVL+ K++ G + + +T + S GTV ++ PE + + ++ K D Sbjct: 283 PNVLVTHTDAVKISDFGTSKELSDKSTKM-SFAGTV------AWLAPEVIRNEPVSEKVD 335 Query: 366 VYSYGVLLLELVTGR-PVVQDDRSLVEW 446 ++S+GV+L EL+TG P D S + W Sbjct: 336 IWSFGVVLWELLTGEIPYKDVDSSAIIW 363
>M3K13_HUMAN (O43283) Mitogen-activated protein kinase kinase kinase 13 (EC| 2.7.11.25) (Mixed lineage kinase) (MLK) (Leucine zipper-bearing kinase) Length = 966 Score = 52.8 bits (125), Expect = 5e-07 Identities = 42/148 (28%), Positives = 72/148 (48%), Gaps = 5/148 (3%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGK----LLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKP 185 + E+ +G L + L + K LL+ W I A+ + YLH + + H D+K Sbjct: 232 IMEYCAHGQLYEVLRAGRKITPRLLVDWSTGI------ASGMNYLHLH---KIIHRDLKS 282 Query: 186 SNVLLDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSD 365 NVL+ K++ G + + +T + S GTV ++ PE + + ++ K D Sbjct: 283 PNVLVTHTDAVKISDFGTSKELSDKSTKM-SFAGTV------AWMAPEVIRNEPVSEKVD 335 Query: 366 VYSYGVLLLELVTGR-PVVQDDRSLVEW 446 ++S+GV+L EL+TG P D S + W Sbjct: 336 IWSFGVVLWELLTGEIPYKDVDSSAIIW 363
>KPC3_DROME (P13678) Protein kinase C (EC 2.7.11.13) (PKC) (dPKC98F)| Length = 634 Score = 52.8 bits (125), Expect = 5e-07 Identities = 42/139 (30%), Positives = 66/139 (47%) Frame = +3 Query: 12 FQVYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSN 191 F V E++ G L + + + A +V AL++LH + + + D+K N Sbjct: 378 FFVMEYVNGGDLMFQIQKARRFEA--SRAAFYAAEVTLALQFLHTH---GVIYRDLKLDN 432 Query: 192 VLLDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVY 371 +LLD+ KLA G+ C G M G T TP Y+ PE + QE A D + Sbjct: 433 ILLDQEGHCKLADFGM--CKEG--IMNGML--TTTFCGTPDYIAPEILKEQEYGASVDWW 486 Query: 372 SYGVLLLELVTGRPVVQDD 428 + GVL+ E++ G+P + D Sbjct: 487 ALGVLMYEMMAGQPPFEAD 505
>LYN_RAT (Q07014) Tyrosine-protein kinase Lyn (EC 2.7.10.2)| Length = 511 Score = 52.8 bits (125), Expect = 5e-07 Identities = 42/131 (32%), Positives = 63/131 (48%), Gaps = 2/131 (1%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSS--GKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSN 191 + EFM GSL D L S K+LLP I + +A + Y+ H D++ +N Sbjct: 317 ITEFMAKGSLLDFLKSDEGSKVLLP--KLIDFSAQIAEGMAYIE---RKNYIHRDLRAAN 371 Query: 192 VLLDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVY 371 VL+ ++ + K+A G+A N I+ T PE + T KSDV+ Sbjct: 372 VLVSESLMCKIADFGLARVIED-NEYTAREGAKFPIKWTA----PEAINFGCFTIKSDVW 426 Query: 372 SYGVLLLELVT 404 S+G+LL E+VT Sbjct: 427 SFGILLYEIVT 437
>KIN16_CAEEL (P34892) Receptor-like tyrosine-protein kinase kin-16 precursor (EC| 2.7.10.1) Length = 495 Score = 52.8 bits (125), Expect = 5e-07 Identities = 36/129 (27%), Positives = 58/129 (44%), Gaps = 1/129 (0%) Frame = +3 Query: 21 YEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVLL 200 Y F D++ L + + + +AN ++YL P+ H D+ NVLL Sbjct: 273 YVFKNTDENSDYVIKESLDSLTTSDLLSFGLQIANGMQYL---ASIPMVHRDLALRNVLL 329 Query: 201 DKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATP-GYVDPEYVVTQELTAKSDVYSY 377 KN ++A G+A + + P K P ++ PE T + T KSDV+S+ Sbjct: 330 KKNKTIRIADFGMARTHENKSYYI---PQKTKDAPVPVRWMSPEAFDTMKFTEKSDVWSF 386 Query: 378 GVLLLELVT 404 G+ L E+ T Sbjct: 387 GICLYEIFT 395
>KPCI_BRARE (Q90XF2) Protein kinase C iota type (EC 2.7.11.13) (nPKC-iota)| (Atypical protein kinase C-lambda/iota) (aPKC-lambda/iota) (Heart and soul protein) Length = 588 Score = 52.8 bits (125), Expect = 5e-07 Identities = 41/133 (30%), Positives = 64/133 (48%) Frame = +3 Query: 12 FQVYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSN 191 F V E++ G L H+ KL P ++ + +++ AL YLH + + + D+K N Sbjct: 321 FFVIEYVNGGDLMFHMQRQRKL--PEEHARFYSAEISLALNYLH---ERGIIYRDLKLDN 375 Query: 192 VLLDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVY 371 VLLD KL G+ C G G T T TP Y+ PE + ++ D + Sbjct: 376 VLLDSEGHIKLTDYGM--CKEG--LRPGDTTST--FCGTPNYIAPEILRGEDYGFSVDWW 429 Query: 372 SYGVLLLELVTGR 410 + GVL+ E++ GR Sbjct: 430 ALGVLMFEMMAGR 442
>RIPK5_CHICK (Q6XUX0) Receptor-interacting serine/threonine-protein kinase 5 (EC| 2.7.11.1) (Dusty protein kinase) (Dusty PK) Length = 930 Score = 52.8 bits (125), Expect = 5e-07 Identities = 41/117 (35%), Positives = 57/117 (48%) Frame = +3 Query: 57 LHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVLLDKNYLAKLAGCG 236 L++ K L + R+QIA+DV + YLH L H DIK NVLLDK AK+ G Sbjct: 742 LYTGLKAGLELETRLQIALDVVEGIRYLH---SQGLVHRDIKLKNVLLDKKNRAKITDLG 798 Query: 237 IAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVYSYGVLLLELVTG 407 M GS G TP ++ PE + T + DVY++G+L + +G Sbjct: 799 FC---KPEAMMSGSIVG------TPIHMAPE-LFTGKYDNSVDVYAFGILFWYICSG 845
>STE20_CANAL (Q92212) Serine/threonine-protein kinase STE20 homolog (EC 2.7.11.1)| Length = 1230 Score = 52.8 bits (125), Expect = 5e-07 Identities = 42/136 (30%), Positives = 62/136 (45%), Gaps = 4/136 (2%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVL 197 + E+ME GSL D + S QI + L+ L F + H DIK N+L Sbjct: 1027 IMEYMEGGSLTDIVTHSVM------TEGQIGVVCRETLKGLKFLHSKGVIHRDIKSDNIL 1080 Query: 198 LDKNYLAKLAGCGIAHCSNGGN----TMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSD 365 L+ + K+ G N N TMVG TP ++ PE V +E K D Sbjct: 1081 LNMDGNIKITDFGFCAQINEINSKRITMVG----------TPYWMAPEIVSRKEYGPKVD 1130 Query: 366 VYSYGVLLLELVTGRP 413 V+S G++++E++ G P Sbjct: 1131 VWSLGIMIIEMLEGEP 1146
>M3K3_MOUSE (Q61084) Mitogen-activated protein kinase kinase kinase 3 (EC| 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3) Length = 626 Score = 52.4 bits (124), Expect = 6e-07 Identities = 38/130 (29%), Positives = 60/130 (46%) Frame = +3 Query: 24 EFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVLLD 203 E+M GS+KD L + G L + + + YLH + H DIK +N+L D Sbjct: 444 EYMPGGSVKDQLKAYGALTESVTRKY--TRQILEGMSYLH---SNMIVHRDIKGANILRD 498 Query: 204 KNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVYSYGV 383 KL G S T+ S G + TP ++ PE + + K+DV+S G Sbjct: 499 SAGNVKLGDFG---ASKRLQTICMSGTGIRSVTGTPYWMSPEVISGEGYGRKADVWSLGC 555 Query: 384 LLLELVTGRP 413 ++E++T +P Sbjct: 556 TVVEMLTEKP 565
>M3K3_HUMAN (Q99759) Mitogen-activated protein kinase kinase kinase 3 (EC| 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3) Length = 626 Score = 52.4 bits (124), Expect = 6e-07 Identities = 38/130 (29%), Positives = 60/130 (46%) Frame = +3 Query: 24 EFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVLLD 203 E+M GS+KD L + G L + + + YLH + H DIK +N+L D Sbjct: 444 EYMPGGSVKDQLKAYGALTESVTRKY--TRQILEGMSYLH---SNMIVHRDIKGANILRD 498 Query: 204 KNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVYSYGV 383 KL G S T+ S G + TP ++ PE + + K+DV+S G Sbjct: 499 SAGNVKLGDFG---ASKRLQTICMSGTGMRSVTGTPYWMSPEVISGEGYGRKADVWSLGC 555 Query: 384 LLLELVTGRP 413 ++E++T +P Sbjct: 556 TVVEMLTEKP 565
>HCK_HUMAN (P08631) Tyrosine-protein kinase HCK (EC 2.7.10.2)| (p59-HCK/p60-HCK) (Hemopoietic cell kinase) Length = 525 Score = 52.4 bits (124), Expect = 6e-07 Identities = 37/129 (28%), Positives = 59/129 (45%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVL 197 + EFM GSL D L S P I + +A + ++ H D++ +N+L Sbjct: 331 ITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIE---QRNYIHRDLRAANIL 387 Query: 198 LDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVYSY 377 + + + K+A G+A N I+ T PE + T KSDV+S+ Sbjct: 388 VSASLVCKIADFGLARVIED-NEYTAREGAKFPIKWTA----PEAINFGSFTIKSDVWSF 442 Query: 378 GVLLLELVT 404 G+LL+E+VT Sbjct: 443 GILLMEIVT 451
>LOK_DROME (O61267) Ovarian-specific serine/threonine-protein kinase Lok (EC| 2.7.11.1) (Protein loki) (dMNK) Length = 476 Score = 52.4 bits (124), Expect = 6e-07 Identities = 44/145 (30%), Positives = 73/145 (50%), Gaps = 6/145 (4%) Frame = +3 Query: 12 FQVYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSN 191 + V EFM G L + + S+ KLL +++ + +A++YLH D + H D+KP N Sbjct: 254 YMVLEFMRGGDLLNRIISN-KLLSEDISKLYF-YQMCHAVKYLH---DRGITHRDLKPDN 308 Query: 192 VLL---DKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVT---QELT 353 VLL D+ L K++ G++ + M + TP YV PE ++T + T Sbjct: 309 VLLETNDEETLLKVSDFGLSKFVQKDSVM-------RTLCGTPLYVAPEVLITGGREAYT 361 Query: 354 AKSDVYSYGVLLLELVTGRPVVQDD 428 K D++S GV+L ++G D+ Sbjct: 362 KKVDIWSLGVVLFTCLSGTLPFSDE 386
>KGP1A_RABIT (O77676) cGMP-dependent protein kinase 1, alpha isozyme (EC| 2.7.11.12) (CGK 1 alpha) (cGKI-alpha) Length = 670 Score = 52.4 bits (124), Expect = 6e-07 Identities = 33/99 (33%), Positives = 47/99 (47%) Frame = +3 Query: 117 VANALEYLHFYCDPPLYHGDIKPSNVLLDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVK 296 V A YLH + + D+KP N++LD AKL G A +G T Sbjct: 467 VVEAFAYLH---SKGIIYRDLKPENLILDHRGYAKLVDFGFAK-------KIGFGKKTWT 516 Query: 297 IQATPGYVDPEYVVTQELTAKSDVYSYGVLLLELVTGRP 413 TP YV PE ++ + +D +S G+L+ EL+TG P Sbjct: 517 FCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSP 555
>KGP1A_HUMAN (Q13976) cGMP-dependent protein kinase 1, alpha isozyme (EC| 2.7.11.12) (CGK 1 alpha) (cGKI-alpha) Length = 670 Score = 52.4 bits (124), Expect = 6e-07 Identities = 33/99 (33%), Positives = 47/99 (47%) Frame = +3 Query: 117 VANALEYLHFYCDPPLYHGDIKPSNVLLDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVK 296 V A YLH + + D+KP N++LD AKL G A +G T Sbjct: 467 VVEAFAYLH---SKGIIYRDLKPENLILDHRGYAKLVDFGFAK-------KIGFGKKTWT 516 Query: 297 IQATPGYVDPEYVVTQELTAKSDVYSYGVLLLELVTGRP 413 TP YV PE ++ + +D +S G+L+ EL+TG P Sbjct: 517 FCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSP 555
>KGP1A_BOVIN (P00516) cGMP-dependent protein kinase 1, alpha isozyme (EC| 2.7.11.12) (CGK 1 alpha) (cGKI-alpha) Length = 670 Score = 52.4 bits (124), Expect = 6e-07 Identities = 33/99 (33%), Positives = 47/99 (47%) Frame = +3 Query: 117 VANALEYLHFYCDPPLYHGDIKPSNVLLDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVK 296 V A YLH + + D+KP N++LD AKL G A +G T Sbjct: 467 VVEAFAYLH---SKGIIYRDLKPENLILDHRGYAKLVDFGFAK-------KIGFGKKTWT 516 Query: 297 IQATPGYVDPEYVVTQELTAKSDVYSYGVLLLELVTGRP 413 TP YV PE ++ + +D +S G+L+ EL+TG P Sbjct: 517 FCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSP 555
>DCAK2_MOUSE (Q6PGN3) Serine/threonine-protein kinase DCAMKL2 (EC 2.7.11.1)| (Doublecortin-like and CAM kinase-like 2) Length = 756 Score = 52.4 bits (124), Expect = 6e-07 Identities = 45/148 (30%), Positives = 66/148 (44%), Gaps = 4/148 (2%) Frame = +3 Query: 12 FQVYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSN 191 F V E ++ G L D + SS K ++ + ++ANAL YLH + H DIKP N Sbjct: 465 FLVMELVKGGDLFDAITSSTKYTE--RDGSAMVYNLANALRYLHSLS---IVHRDIKPEN 519 Query: 192 VLL----DKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAK 359 +L+ D KL G+A G + TP YV PE + K Sbjct: 520 LLVCEYPDGTKSLKLGDFGLATVVEGP---------LYTVCGTPTYVAPEIIAETGYGLK 570 Query: 360 SDVYSYGVLLLELVTGRPVVQDDRSLVE 443 DV++ GV+ L+ G P + + +L E Sbjct: 571 VDVWAAGVITYILLCGFPPFRSENNLQE 598
>YES_CANFA (Q28923) Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2)| (p61-Yes) (c-Yes) Length = 538 Score = 52.4 bits (124), Expect = 6e-07 Identities = 38/129 (29%), Positives = 58/129 (44%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVL 197 V EFM GSL D L L + +A +A+ + Y+ H D++ +N+L Sbjct: 342 VTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERM---NYIHRDLRAANIL 398 Query: 198 LDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVYSY 377 + +N + K+A G+A N I+ T PE + T KSDV+S+ Sbjct: 399 VGENLVCKIADFGLARLIED-NEYTARQGAKFPIKWTA----PEAALYGRFTIKSDVWSF 453 Query: 378 GVLLLELVT 404 G+L EL T Sbjct: 454 GILQTELTT 462
>STE7_CANAL (P46599) Serine/threonine-protein kinase STE7 homolog (EC 2.7.12.2)| Length = 589 Score = 52.4 bits (124), Expect = 6e-07 Identities = 34/109 (31%), Positives = 54/109 (49%) Frame = +3 Query: 102 QIAIDVANALEYLHFYCDPPLYHGDIKPSNVLLDKNYLAKLAGCGIAHCSNGGNTMVGST 281 +++ + + L YL Y + H DIKP+NVL+ KL G++ M + Sbjct: 352 KLSFAILSGLTYL--YTTHKIIHRDIKPNNVLMTHKGEFKLCDFGVSRELTNSLAMADTF 409 Query: 282 PGTVKIQATPGYVDPEYVVTQELTAKSDVYSYGVLLLELVTGRPVVQDD 428 GT Y+ PE + + KSDV+S G++L+EL +G PV +D Sbjct: 410 VGTSM------YMSPERIQGLDYGVKSDVWSTGLMLIELASGVPVWSED 452
>GUC2C_PIG (P55204) Heat-stable enterotoxin receptor precursor (GC-C)| (Intestinal guanylate cyclase) (EC 4.6.1.2) (STA receptor) Length = 1073 Score = 52.4 bits (124), Expect = 6e-07 Identities = 33/137 (24%), Positives = 61/137 (44%), Gaps = 4/137 (2%) Frame = +3 Query: 12 FQVYEFMENGSLKDHLHSS----GKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDI 179 F V E+ E GSL++ L+ + + W+ +I + D+A + YLH HG + Sbjct: 558 FGVIEYCERGSLREVLNDTISYPDGTFMDWEFKISVLYDIAKGMSYLH--SSKTEVHGRL 615 Query: 180 KPSNVLLDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAK 359 K +N ++D + K+ G ++ + PE++ ++ K Sbjct: 616 KSTNCVVDSRMVVKITDFGC---------------NSILAPKKDLWTAPEHLRRASVSQK 660 Query: 360 SDVYSYGVLLLELVTGR 410 DVYSYG++ E++ R Sbjct: 661 GDVYSYGIIAQEIILRR 677
>KAPB_SCHPO (P40376) cAMP-dependent protein kinase catalytic subunit (EC| 2.7.11.11) Length = 512 Score = 52.4 bits (124), Expect = 6e-07 Identities = 40/134 (29%), Positives = 60/134 (44%) Frame = +3 Query: 12 FQVYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSN 191 F V +F E G L L + P K A +V AL+YLH + + D+KP N Sbjct: 275 FMVMDFAEGGELFSLLRKCHRF--PEKVAKFYAAEVILALDYLHHN---QIVYRDLKPEN 329 Query: 192 VLLDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVY 371 +LLD+ K+ G A ST + TP Y+ PE + + +D + Sbjct: 330 LLLDRFGHLKIVDFGFAKRV--------STSNCCTLCGTPDYLAPEIISLKPYNKAADWW 381 Query: 372 SYGVLLLELVTGRP 413 S G+L+ E++ G P Sbjct: 382 SLGILIFEMLAGYP 395
>ULK1_MOUSE (O70405) Serine/threonine-protein kinase ULK1 (EC 2.7.11.1)| (Unc-51-like kinase 1) (Serine/threonine-protein kinase Unc51.1) Length = 1051 Score = 52.4 bits (124), Expect = 6e-07 Identities = 39/147 (26%), Positives = 69/147 (46%), Gaps = 10/147 (6%) Frame = +3 Query: 12 FQVYEFMENGSLKDHLHSSGKLLLPWKNRIQIAID-VANALEYLHFYCDPPLYHGDIKPS 188 + V E+ G L D+LH+ L ++ +++ + +A A+ LH + H D+KP Sbjct: 89 YLVMEYCNGGDLADYLHTMRTLS---EDTVRLFLQQIAGAMRLLH---SKGIIHRDLKPQ 142 Query: 189 NVLLDK---------NYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVT 341 N+LL N K+A G A N M + G+ P Y+ PE +++ Sbjct: 143 NILLSNPGGRRANPSNIRVKIADFGFARYLQS-NMMAATLCGS------PMYMAPEVIMS 195 Query: 342 QELTAKSDVYSYGVLLLELVTGRPVVQ 422 Q K+D++S G ++ + +TG+ Q Sbjct: 196 QHYDGKADLWSIGTIVYQCLTGKAPFQ 222
>LRRK2_MOUSE (Q5S006) Leucine-rich repeat serine/threonine-protein kinase 2 (EC| 2.7.11.1) Length = 2527 Score = 52.4 bits (124), Expect = 6e-07 Identities = 49/140 (35%), Positives = 66/140 (47%), Gaps = 8/140 (5%) Frame = +3 Query: 9 RFQVYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPS 188 R V E GSL D L K L + +IA+ VA+ L YLH + + D+KP Sbjct: 1943 RMLVMELASKGSL-DRLLQQDKASLTRTLQHRIALHVADGLRYLH---SAMIIYRDLKPH 1998 Query: 189 NVLLDKNY-----LAKLAGCGIAH--CSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQE 347 NVLL Y +AK+A GIA C G T G TPG+ PE Sbjct: 1999 NVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEG----------TPGFRAPEVARGNV 2048 Query: 348 L-TAKSDVYSYGVLLLELVT 404 + ++DVYS+G+LL ++ T Sbjct: 2049 IYNQQADVYSFGLLLHDIWT 2068
>TIE2_MOUSE (Q02858) Angiopoietin-1 receptor precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (HYK) (STK1) (CD202b antigen) Length = 1122 Score = 52.4 bits (124), Expect = 6e-07 Identities = 42/141 (29%), Positives = 65/141 (46%), Gaps = 14/141 (9%) Frame = +3 Query: 24 EFMENGSLKDHLHSSGKL--------------LLPWKNRIQIAIDVANALEYLHFYCDPP 161 E+ +G+L D L S L L + + A DVA ++YL Sbjct: 901 EYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLS---QKQ 957 Query: 162 LYHGDIKPSNVLLDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVT 341 H D+ N+L+ +NY+AK+A G+ S G V T G + ++ ++ E + Sbjct: 958 FIHRDLAARNILVGENYIAKIADFGL---SRGQEVYVKKTMGRLPVR----WMAIESLNY 1010 Query: 342 QELTAKSDVYSYGVLLLELVT 404 T SDV+SYGVLL E+V+ Sbjct: 1011 SVYTTNSDVWSYGVLLWEIVS 1031
>LCK_CHICK (P42683) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (Protein-tyrosine kinase C-TKL) (p56tk1) Length = 507 Score = 52.4 bits (124), Expect = 6e-07 Identities = 37/129 (28%), Positives = 61/129 (47%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVL 197 + E+ME GSL D L +S + L + +A +A + ++ H D++ +N+L Sbjct: 313 ITEYMEKGSLVDFLKTSEGIKLSINKLLDMAAQIAEGMAFIEA---KNYIHRDLRAANIL 369 Query: 198 LDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVYSY 377 + + K+A G+A N I+ T PE + T KSDV+S+ Sbjct: 370 VSEALCCKIADFGLARLIED-NEYTAREGAKFPIKWTA----PEAINYGTFTIKSDVWSF 424 Query: 378 GVLLLELVT 404 G+LL E+VT Sbjct: 425 GILLTEIVT 433
>NEK6_RAT (P59895) Serine/threonine-protein kinase Nek6 (EC 2.7.11.1)| (NimA-related protein kinase 6) Length = 313 Score = 52.4 bits (124), Expect = 6e-07 Identities = 41/155 (26%), Positives = 67/155 (43%), Gaps = 3/155 (1%) Frame = +3 Query: 18 VYEFMENGSLKDHLH--SSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSN 191 V E + G L + K L+P + + + + +A+E++H + H DIKP+N Sbjct: 121 VLELADAGDLSQMIKYFKKQKRLIPERTVWKYFVQLCSAVEHMH---SRRVMHRDIKPAN 177 Query: 192 VLLDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVY 371 V + + KL G+ + T S GT P Y+ PE + KSD++ Sbjct: 178 VFITATGIVKLGDLGLGRFFSSETTAAHSLVGT------PYYMSPERIHENGYNFKSDIW 231 Query: 372 SYGVLLLELVT-GRPVVQDDRSLVEWSRELIGTDY 473 S G LL E+ P D +L +++ DY Sbjct: 232 SLGCLLYEMAALQSPFYGDKMNLFSLCQKIEQCDY 266
>NEK6_MOUSE (Q9ES70) Serine/threonine-protein kinase Nek6 (EC 2.7.11.1)| (NimA-related protein kinase 6) Length = 313 Score = 52.4 bits (124), Expect = 6e-07 Identities = 41/155 (26%), Positives = 67/155 (43%), Gaps = 3/155 (1%) Frame = +3 Query: 18 VYEFMENGSLKDHLH--SSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSN 191 V E + G L + K L+P + + + + +A+E++H + H DIKP+N Sbjct: 121 VLELADAGDLSQMIKYFKKQKRLIPERTVWKYFVQLCSAVEHMH---SRRVMHRDIKPAN 177 Query: 192 VLLDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVY 371 V + + KL G+ + T S GT P Y+ PE + KSD++ Sbjct: 178 VFITATGIVKLGDLGLGRFFSSETTAAHSLVGT------PYYMSPERIHENGYNFKSDIW 231 Query: 372 SYGVLLLELVT-GRPVVQDDRSLVEWSRELIGTDY 473 S G LL E+ P D +L +++ DY Sbjct: 232 SLGCLLYEMAALQSPFYGDKMNLFSLCQKIEQCDY 266
>KGP1B_MOUSE (Q9Z0Z0) cGMP-dependent protein kinase 1, beta isozyme (EC| 2.7.11.12) (cGK 1 beta) (cGKI-beta) Length = 686 Score = 52.4 bits (124), Expect = 6e-07 Identities = 33/99 (33%), Positives = 47/99 (47%) Frame = +3 Query: 117 VANALEYLHFYCDPPLYHGDIKPSNVLLDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVK 296 V A YLH + + D+KP N++LD AKL G A +G T Sbjct: 483 VVEAFAYLH---SKGIIYRDLKPENLILDHRGYAKLVDFGFAK-------KIGFGKKTWT 532 Query: 297 IQATPGYVDPEYVVTQELTAKSDVYSYGVLLLELVTGRP 413 TP YV PE ++ + +D +S G+L+ EL+TG P Sbjct: 533 FCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSP 571
>KGP1B_HUMAN (P14619) cGMP-dependent protein kinase 1, beta isozyme (EC| 2.7.11.12) (cGK 1 beta) (cGKI-beta) Length = 686 Score = 52.4 bits (124), Expect = 6e-07 Identities = 33/99 (33%), Positives = 47/99 (47%) Frame = +3 Query: 117 VANALEYLHFYCDPPLYHGDIKPSNVLLDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVK 296 V A YLH + + D+KP N++LD AKL G A +G T Sbjct: 483 VVEAFAYLH---SKGIIYRDLKPENLILDHRGYAKLVDFGFAK-------KIGFGKKTWT 532 Query: 297 IQATPGYVDPEYVVTQELTAKSDVYSYGVLLLELVTGRP 413 TP YV PE ++ + +D +S G+L+ EL+TG P Sbjct: 533 FCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSP 571
>KGP1B_BOVIN (P21136) cGMP-dependent protein kinase 1, beta isozyme (EC| 2.7.11.12) (cGK 1 beta) (cGKI-beta) Length = 686 Score = 52.4 bits (124), Expect = 6e-07 Identities = 33/99 (33%), Positives = 47/99 (47%) Frame = +3 Query: 117 VANALEYLHFYCDPPLYHGDIKPSNVLLDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVK 296 V A YLH + + D+KP N++LD AKL G A +G T Sbjct: 483 VVEAFAYLH---SKGIIYRDLKPENLILDHRGYAKLVDFGFAK-------KIGFGKKTWT 532 Query: 297 IQATPGYVDPEYVVTQELTAKSDVYSYGVLLLELVTGRP 413 TP YV PE ++ + +D +S G+L+ EL+TG P Sbjct: 533 FCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSP 571
>SRC_RSVSE (P63185) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 52.0 bits (123), Expect = 8e-07 Identities = 38/129 (29%), Positives = 59/129 (45%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVL 197 V E+M GSL D L L + +A +A+ + Y+ H D++ +N+L Sbjct: 336 VIEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERM---NYVHRDLRAANIL 392 Query: 198 LDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVYSY 377 + +N + K+A G+A N I+ T PE + T KSDV+S+ Sbjct: 393 VGENLVCKVADFGLARLIED-NEYTARQGAKFPIKWTA----PEAALYGRFTIKSDVWSF 447 Query: 378 GVLLLELVT 404 G+LL EL T Sbjct: 448 GILLTELTT 456
>SRC_RSVP (P00526) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 52.0 bits (123), Expect = 8e-07 Identities = 38/129 (29%), Positives = 59/129 (45%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVL 197 V E+M GSL D L L + +A +A+ + Y+ H D++ +N+L Sbjct: 336 VIEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERM---NYVHRDLRAANIL 392 Query: 198 LDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVYSY 377 + +N + K+A G+A N I+ T PE + T KSDV+S+ Sbjct: 393 VGENLVCKVADFGLARLIED-NEYTARQGAKFPIKWTA----PEAALYGRFTIKSDVWSF 447 Query: 378 GVLLLELVT 404 G+LL EL T Sbjct: 448 GILLTELTT 456
>SRC_RSVH1 (P25020) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 52.0 bits (123), Expect = 8e-07 Identities = 38/129 (29%), Positives = 59/129 (45%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVL 197 V E+M GSL D L L + +A +A+ + Y+ H D++ +N+L Sbjct: 336 VIEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERM---NYVHRDLRAANIL 392 Query: 198 LDKNYLAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVYSY 377 + +N + K+A G+A N I+ T PE + T KSDV+S+ Sbjct: 393 VGENLVCKVADFGLARLIED-NEYTARQGAKFPIKWTA----PEAALYGRFTIKSDVWSF 447 Query: 378 GVLLLELVT 404 G+LL EL T Sbjct: 448 GILLTELTT 456
>JAK_DROME (Q24592) Tyrosine-protein kinase hopscotch (EC 2.7.10.2)| Length = 1177 Score = 52.0 bits (123), Expect = 8e-07 Identities = 36/130 (27%), Positives = 64/130 (49%), Gaps = 3/130 (2%) Frame = +3 Query: 18 VYEFMENGSLKDHLHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVL 197 + E++++GS +L + L + A+D+AN ++YL D L H D+ N+L Sbjct: 966 IMEYLQSGSFDIYLRFTAPNLNN-PRLVSFALDIANGMKYLS---DMGLIHRDLAARNIL 1021 Query: 198 LDKNY---LAKLAGCGIAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDV 368 +D N K++ G+A +N + + I+ + PE + T ++ SDV Sbjct: 1022 VDHNGDGDCVKISDFGLAQFANSDGYYYAKSKRDIPIR----WYSPEAISTCRFSSYSDV 1077 Query: 369 YSYGVLLLEL 398 +SYGV L E+ Sbjct: 1078 WSYGVTLFEM 1087
>RIPK5_FUGRU (Q4VSN2) Receptor-interacting serine/threonine-protein kinase 5 (EC| 2.7.11.1) (Dusty protein kinase) (Dusty PK) Length = 921 Score = 52.0 bits (123), Expect = 8e-07 Identities = 41/117 (35%), Positives = 57/117 (48%) Frame = +3 Query: 57 LHSSGKLLLPWKNRIQIAIDVANALEYLHFYCDPPLYHGDIKPSNVLLDKNYLAKLAGCG 236 L++ K L + R+QIA+DV + +LH + L H DIK NVLLDK AK+ G Sbjct: 734 LYTGLKAGLSLQERLQIALDVVEGIRFLH---NQGLLHRDIKLKNVLLDKQNRAKITDLG 790 Query: 237 IAHCSNGGNTMVGSTPGTVKIQATPGYVDPEYVVTQELTAKSDVYSYGVLLLELVTG 407 M GS G TP ++ PE + T + DVY++G+L L G Sbjct: 791 FC---KPEAMMSGSIVG------TPIHMAPE-LFTGKYDNSVDVYAFGILFWYLCAG 837 Database: uniprot_sprot.fasta Posted date: May 25, 2006 5:36 PM Number of letters in database: 80,573,946 Number of sequences in database: 219,361 Lambda K H 0.318 0.135 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 77,356,884 Number of Sequences: 219361 Number of extensions: 1799859 Number of successful extensions: 8700 Number of sequences better than 10.0: 500 Number of HSP's better than 10.0 without gapping: 7231 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 7658 length of database: 80,573,946 effective HSP length: 103 effective length of database: 57,979,763 effective search space used: 3130907202 frameshift window, decay const: 50, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)
