ナショナルバイオリソースプロジェクト
-Barley Genetic Resources Database-
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| Clone Name | bast52a07 |
|---|---|
| Clone Library Name | barley_pub |
>BRL1_ARATH (Q9ZWC8) Serine/threonine-protein kinase BRI1-like 1 precursor (EC| 2.7.11.1) (BRASSINOSTEROID INSENSITIVE 1-like protein 1) Length = 1166 Score = 106 bits (265), Expect = 3e-23 Identities = 63/140 (45%), Positives = 86/140 (61%), Gaps = 4/140 (2%) Frame = +2 Query: 5 EGTVLAILRLPSTSADGAVVVEEGSFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVY 184 +G+V+AI +L + G + F E E++G++KHRNL L GY + RLLVY Sbjct: 880 DGSVVAIKKLIRITGQG-----DREFMAEMETIGKIKHRNLVPLLGYCK--VGEERLLVY 932 Query: 185 DYMPNGNLATLLQEASHQDGHI-LNWPMRHLIALGVSRGLAFLHQS---GVIHGDVKPQN 352 +YM G+L T+L E S + G I LNW R IA+G +RGLAFLH S +IH D+K N Sbjct: 933 EYMKWGSLETVLHEKSSKKGGIYLNWAARKKIAIGAARGLAFLHHSCIPHIIHRDMKSSN 992 Query: 353 ILFDADFEPHLSDFGLEPMV 412 +L D DFE +SDFG+ +V Sbjct: 993 VLLDEDFEARVSDFGMARLV 1012
>BRL3_ARATH (Q9LJF3) Serine/threonine-protein kinase BRI1-like 3 precursor (EC| 2.7.11.1) (BRASSINOSTEROID INSENSITIVE 1-like protein 3) Length = 1164 Score = 105 bits (261), Expect = 9e-23 Identities = 59/140 (42%), Positives = 85/140 (60%), Gaps = 3/140 (2%) Frame = +2 Query: 2 SEGTVLAILRLPSTSADGAVVVEEGSFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLV 181 ++G+V+AI +L + G + F E E++G++KHRNL L GY + RLLV Sbjct: 878 ADGSVVAIKKLIQVTGQG-----DREFMAEMETIGKIKHRNLVPLLGYCK--IGEERLLV 930 Query: 182 YDYMPNGNLATLLQEASHQDGHILNWPMRHLIALGVSRGLAFLHQS---GVIHGDVKPQN 352 Y+YM G+L T+L E + + G L+W R IA+G +RGLAFLH S +IH D+K N Sbjct: 931 YEYMKYGSLETVLHEKTKKGGIFLDWSARKKIAIGAARGLAFLHHSCIPHIIHRDMKSSN 990 Query: 353 ILFDADFEPHLSDFGLEPMV 412 +L D DF +SDFG+ +V Sbjct: 991 VLLDQDFVARVSDFGMARLV 1010
>BRI1_LYCPE (Q8L899) Systemin receptor SR160 precursor (EC 2.7.11.1)| (Brassinosteroid LRR receptor kinase) Length = 1207 Score = 98.2 bits (243), Expect = 1e-20 Identities = 57/135 (42%), Positives = 81/135 (60%), Gaps = 3/135 (2%) Frame = +2 Query: 5 EGTVLAILRLPSTSADGAVVVEEGSFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVY 184 +G+V+AI +L S G + F E E++G++KHRNL L GY + RLLVY Sbjct: 909 DGSVVAIKKLIHVSGQG-----DREFTAEMETIGKIKHRNLVPLLGYCK--VGEERLLVY 961 Query: 185 DYMPNGNLATLLQEASHQDGHILNWPMRHLIALGVSRGLAFLHQS---GVIHGDVKPQNI 355 +YM G+L +L + + G LNWP R IA+G +RGLAFLH + +IH D+K N+ Sbjct: 962 EYMKYGSLEDVLHDRK-KTGIKLNWPARRKIAIGAARGLAFLHHNCIPHIIHRDMKSSNV 1020 Query: 356 LFDADFEPHLSDFGL 400 L D + E +SDFG+ Sbjct: 1021 LLDENLEARVSDFGM 1035
>CLV1_ARATH (Q9SYQ8) Receptor protein kinase CLAVATA1 precursor (EC 2.7.11.1)| Length = 980 Score = 97.4 bits (241), Expect = 2e-20 Identities = 51/115 (44%), Positives = 73/115 (63%), Gaps = 3/115 (2%) Frame = +2 Query: 80 FRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHILNW 259 F E ++LGR++HR++ L GY A D LL+Y+YMPNG+L LL + + GH L W Sbjct: 734 FTAEIQTLGRIRHRHIVRLLGYVANK--DTNLLLYEYMPNGSLGELLHGS--KGGH-LQW 788 Query: 260 PMRHLIALGVSRGLAFLHQSG---VIHGDVKPQNILFDADFEPHLSDFGLEPMVV 415 RH +A+ ++GL +LH ++H DVK NIL D+DFE H++DFGL +V Sbjct: 789 ETRHRVAVEAAKGLCYLHHDCSPLILHRDVKSNNILLDSDFEAHVADFGLAKFLV 843
>BRI1_LYCES (Q8GUQ5) Brassinosteroid LRR receptor kinase precursor (EC 2.7.11.1)| (tBRI1) (Altered brassinolide sensitivity 1) (Systemin receptor SR160) Length = 1207 Score = 97.4 bits (241), Expect = 2e-20 Identities = 57/135 (42%), Positives = 81/135 (60%), Gaps = 3/135 (2%) Frame = +2 Query: 5 EGTVLAILRLPSTSADGAVVVEEGSFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVY 184 +G+V+AI +L S G + F E E++G++KHRNL L GY + RLLVY Sbjct: 909 DGSVVAIKKLIHVSGQG-----DREFTAEMETIGKIKHRNLVPLLGYCK--VGEERLLVY 961 Query: 185 DYMPNGNLATLLQEASHQDGHILNWPMRHLIALGVSRGLAFLHQS---GVIHGDVKPQNI 355 +YM G+L +L + + G LNWP R IA+G +RGLAFLH + +IH D+K N+ Sbjct: 962 EYMKYGSLEDVLHDRK-KIGIKLNWPARRKIAIGAARGLAFLHHNCIPHIIHRDMKSSNV 1020 Query: 356 LFDADFEPHLSDFGL 400 L D + E +SDFG+ Sbjct: 1021 LLDENLEARVSDFGM 1035
>BAK1_ARATH (Q94F62) BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1| precursor (EC 2.7.11.1) (BRI1-associated receptor kinase 1) (Somatic embryogenesis receptor-like kinase 3) Length = 615 Score = 96.3 bits (238), Expect = 4e-20 Identities = 59/140 (42%), Positives = 79/140 (56%), Gaps = 3/140 (2%) Frame = +2 Query: 2 SEGTVLAILRLPSTSADGAVVVEEGSFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLV 181 ++GT++A+ RL G E F+ E E + HRNL LRG+ P RLLV Sbjct: 309 ADGTLVAVKRLKEERTQGG----ELQFQTEVEMISMAVHRNLLRLRGFCMTPTE--RLLV 362 Query: 182 YDYMPNGNLATLLQEASHQDGHILNWPMRHLIALGVSRGLAFLHQS---GVIHGDVKPQN 352 Y YM NG++A+ L+E L+WP R IALG +RGLA+LH +IH DVK N Sbjct: 363 YPYMANGSVASCLRERPESQPP-LDWPKRQRIALGSARGLAYLHDHCDPKIIHRDVKAAN 421 Query: 353 ILFDADFEPHLSDFGLEPMV 412 IL D +FE + DFGL ++ Sbjct: 422 ILLDEEFEAVVGDFGLAKLM 441
>RPK1_IPONI (P93194) Receptor-like protein kinase precursor (EC 2.7.11.1)| Length = 1109 Score = 93.6 bits (231), Expect = 3e-19 Identities = 53/140 (37%), Positives = 80/140 (57%), Gaps = 3/140 (2%) Frame = +2 Query: 2 SEGTVLAILRLPSTSADGAVVVEEGSFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLV 181 S V A+ +L T V S +E E++G+V+HRNL L ++ + L++ Sbjct: 836 SPDKVYAVKKLVFTGIKNGSV----SMVREIETIGKVRHRNLIKLEEFWLRK--EYGLIL 889 Query: 182 YDYMPNGNLATLLQEASHQDGHILNWPMRHLIALGVSRGLAFLH---QSGVIHGDVKPQN 352 Y YM NG+L +L E + L+W RH IA+G + GLA+LH ++H D+KP N Sbjct: 890 YTYMENGSLHDILHETNPPKP--LDWSTRHNIAVGTAHGLAYLHFDCDPAIVHRDIKPMN 947 Query: 353 ILFDADFEPHLSDFGLEPMV 412 IL D+D EPH+SDFG+ ++ Sbjct: 948 ILLDSDLEPHISDFGIAKLL 967
>TMKL1_ARATH (P33543) Putative kinase-like protein TMKL1 precursor| Length = 674 Score = 93.2 bits (230), Expect = 3e-19 Identities = 48/108 (44%), Positives = 73/108 (67%), Gaps = 3/108 (2%) Frame = +2 Query: 101 LGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHILNWPMRHLIA 280 LGR++H NL LR +Y G + +LL+YDY+PN +L LL E+ + LNW RH IA Sbjct: 421 LGRIRHENLVPLRAFYQGKRGE-KLLIYDYLPNISLHDLLHESKPRKP-ALNWARRHKIA 478 Query: 281 LGVSRGLAFLH---QSGVIHGDVKPQNILFDADFEPHLSDFGLEPMVV 415 LG++RGLA+LH + +IHG+++ +N+L D F L++FGL+ ++V Sbjct: 479 LGIARGLAYLHTGQEVPIIHGNIRSKNVLVDDFFFARLTEFGLDKIMV 526
>EXS_ARATH (Q9LYN8) Leucine-rich repeat receptor protein kinase EXS precursor| (EC 2.7.11.1) (Extra sporogenous cells protein) (EXCESS MICROSPOROCYTES1 protein) Length = 1192 Score = 92.4 bits (228), Expect = 6e-19 Identities = 54/116 (46%), Positives = 73/116 (62%), Gaps = 5/116 (4%) Frame = +2 Query: 80 FRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDG--HIL 253 F E E+LG+VKH NL L GY + + +LLVY+YM NG+L L+ +Q G +L Sbjct: 958 FMAEMETLGKVKHPNLVSLLGYCSFS--EEKLLVYEYMVNGSLDHWLR---NQTGMLEVL 1012 Query: 254 NWPMRHLIALGVSRGLAFLHQS---GVIHGDVKPQNILFDADFEPHLSDFGLEPMV 412 +W R IA+G +RGLAFLH +IH D+K NIL D DFEP ++DFGL ++ Sbjct: 1013 DWSKRLKIAVGAARGLAFLHHGFIPHIIHRDIKASNILLDGDFEPKVADFGLARLI 1068
>BRI1_ARATH (O22476) BRASSINOSTEROID INSENSITIVE 1 precursor (EC 2.7.11.1)| (AtBRI1) (Brassinosteroid LRR receptor kinase) Length = 1196 Score = 92.4 bits (228), Expect = 6e-19 Identities = 55/135 (40%), Positives = 79/135 (58%), Gaps = 3/135 (2%) Frame = +2 Query: 5 EGTVLAILRLPSTSADGAVVVEEGSFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVY 184 +G+ +AI +L S G + F E E++G++KHRNL L GY D RLLVY Sbjct: 904 DGSAVAIKKLIHVSGQG-----DREFMAEMETIGKIKHRNLVPLLGYCK--VGDERLLVY 956 Query: 185 DYMPNGNLATLLQEASHQDGHILNWPMRHLIALGVSRGLAFLHQS---GVIHGDVKPQNI 355 ++M G+L +L + + G LNW R IA+G +RGLAFLH + +IH D+K N+ Sbjct: 957 EFMKYGSLEDVLHDPK-KAGVKLNWSTRRKIAIGSARGLAFLHHNCSPHIIHRDMKSSNV 1015 Query: 356 LFDADFEPHLSDFGL 400 L D + E +SDFG+ Sbjct: 1016 LLDENLEARVSDFGM 1030
>BRL2_ARATH (Q9ZPS9) Serine/threonine-protein kinase BRI1-like 2 precursor (EC| 2.7.11.1) (BRASSINOSTEROID INSENSITIVE 1-like protein 2) (Protein VASCULAR HIGHWAY 1) Length = 1143 Score = 86.3 bits (212), Expect = 4e-17 Identities = 53/140 (37%), Positives = 78/140 (55%), Gaps = 4/140 (2%) Frame = +2 Query: 5 EGTVLAILRLPSTSADGAVVVEEGSFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVY 184 +G+ +AI +L S G + F E E+LG++KHRNL L GY + RLLVY Sbjct: 859 DGSSVAIKKLIRLSCQG-----DREFMAEMETLGKIKHRNLVPLLGYCK--IGEERLLVY 911 Query: 185 DYMPNGNLATLLQ-EASHQDGHILNWPMRHLIALGVSRGLAFLHQS---GVIHGDVKPQN 352 ++M G+L +L + + IL W R IA G ++GL FLH + +IH D+K N Sbjct: 912 EFMQYGSLEEVLHGPRTGEKRRILGWEERKKIAKGAAKGLCFLHHNCIPHIIHRDMKSSN 971 Query: 353 ILFDADFEPHLSDFGLEPMV 412 +L D D E +SDFG+ ++ Sbjct: 972 VLLDQDMEARVSDFGMARLI 991
>KPRO_MAIZE (P17801) Putative receptor protein kinase ZmPK1 precursor (EC| 2.7.11.1) Length = 817 Score = 85.1 bits (209), Expect = 9e-17 Identities = 50/110 (45%), Positives = 68/110 (61%), Gaps = 3/110 (2%) Frame = +2 Query: 80 FRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHILNW 259 F+ E +GR+ H NL + G+ + RLLV +Y+ NG+LA +L S +L+W Sbjct: 574 FQAELSVIGRINHMNLVRIWGFCS--EGSHRLLVSEYVENGSLANIL--FSEGGNILLDW 629 Query: 260 PMRHLIALGVSRGLAFLHQS---GVIHGDVKPQNILFDADFEPHLSDFGL 400 R IALGV++GLA+LH VIH DVKP+NIL D FEP ++DFGL Sbjct: 630 EGRFNIALGVAKGLAYLHHECLEWVIHCDVKPENILLDQAFEPKITDFGL 679
>RLK5_ARATH (P47735) Receptor-like protein kinase 5 precursor (EC 2.7.11.1)| Length = 999 Score = 84.7 bits (208), Expect = 1e-16 Identities = 50/139 (35%), Positives = 78/139 (56%), Gaps = 8/139 (5%) Frame = +2 Query: 8 GTVLAILRLPSTSADGAVVVEEGS-----FRKEAESLGRVKHRNLTVLRGYYAGPPPDVR 172 G V+A+ +L + G S F E E+LG ++H++ ++R + D + Sbjct: 705 GEVVAVKKLNKSVKGGDDEYSSDSLNRDVFAAEVETLGTIRHKS--IVRLWCCCSSGDCK 762 Query: 173 LLVYDYMPNGNLATLLQEASHQDGHILNWPMRHLIALGVSRGLAFLHQS---GVIHGDVK 343 LLVY+YMPNG+LA +L + G +L WP R IAL + GL++LH ++H DVK Sbjct: 763 LLVYEYMPNGSLADVL-HGDRKGGVVLGWPERLRIALDAAEGLSYLHHDCVPPIVHRDVK 821 Query: 344 PQNILFDADFEPHLSDFGL 400 NIL D+D+ ++DFG+ Sbjct: 822 SSNILLDSDYGAKVADFGI 840
>PSKR_ARATH (Q9ZVR7) Putative phytosulfokine receptor precursor (EC 2.7.11.1)| (Phytosulfokine LRR receptor kinase) Length = 1008 Score = 83.6 bits (205), Expect = 3e-16 Identities = 54/145 (37%), Positives = 76/145 (52%), Gaps = 4/145 (2%) Frame = +2 Query: 71 EGSFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGH- 247 E F E E+L R +H NL +LRG+ + RLL+Y YM NG+L L E + DG Sbjct: 772 EREFEAEVETLSRAQHPNLVLLRGFCFYK--NDRLLIYSYMENGSLDYWLHERN--DGPA 827 Query: 248 ILNWPMRHLIALGVSRGLAFLHQS---GVIHGDVKPQNILFDADFEPHLSDFGLEPMVVX 418 +L W R IA G ++GL +LH+ ++H D+K NIL D +F HL+DFGL ++ Sbjct: 828 LLKWKTRLRIAQGAAKGLLYLHEGCDPHILHRDIKSSNILLDENFNSHLADFGLARLM-- 885 Query: 419 XXXXXXXXXXXXXXXXXPVGSLGYV 493 VG+LGY+ Sbjct: 886 -------SPYETHVSTDLVGTLGYI 903
>PSKR_DAUCA (Q8LPB4) Phytosulfokine receptor precursor (EC 2.7.11.1)| (Phytosulfokine LRR receptor kinase) Length = 1021 Score = 81.6 bits (200), Expect = 1e-15 Identities = 63/167 (37%), Positives = 85/167 (50%), Gaps = 4/167 (2%) Frame = +2 Query: 5 EGTVLAILRLPSTSADGAVVVEEGSFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVY 184 +GT +AI RL S D + E F+ E E+L R +H NL L GY + +LL+Y Sbjct: 764 DGTKVAIKRL---SGDTGQMDRE--FQAEVETLSRAQHPNLVHLLGYCNYK--NDKLLIY 816 Query: 185 DYMPNGNLATLLQEASHQDGH-ILNWPMRHLIALGVSRGLAFLHQS---GVIHGDVKPQN 352 YM NG+L L E DG L+W R IA G + GLA+LHQS ++H D+K N Sbjct: 817 SYMDNGSLDYWLHEKV--DGPPSLDWKTRLRIARGAAEGLAYLHQSCEPHILHRDIKSSN 874 Query: 353 ILFDADFEPHLSDFGLEPMVVXXXXXXXXXXXXXXXXXXPVGSLGYV 493 IL F HL+DFGL +++ VG+LGY+ Sbjct: 875 ILLSDTFVAHLADFGLARLILPYDTHVTTDL---------VGTLGYI 912
>CX32_ARATH (P27450) Probable serine/threonine-protein kinase Cx32, chloroplast| precursor (EC 2.7.11.1) Length = 419 Score = 80.9 bits (198), Expect = 2e-15 Identities = 54/133 (40%), Positives = 71/133 (53%), Gaps = 2/133 (1%) Frame = +2 Query: 8 GTVLAILRLPSTSADGAVVVEEGSFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYD 187 G ++AI RL S S G +R E LG + HRNL L GY LLVY+ Sbjct: 118 GMIVAIKRLNSESVQGFA-----EWRSEVNFLGMLSHRNLVKLLGYCREDKE--LLLVYE 170 Query: 188 YMPNGNLATLLQEASHQDGHILNWPMRHLIALGVSRGLAFLH--QSGVIHGDVKPQNILF 361 +MP G+L + L + W +R I +G +RGLAFLH Q VI+ D K NIL Sbjct: 171 FMPKGSLESHLFRRNDP----FPWDLRIKIVIGAARGLAFLHSLQREVIYRDFKASNILL 226 Query: 362 DADFEPHLSDFGL 400 D++++ LSDFGL Sbjct: 227 DSNYDAKLSDFGL 239
>TMK1_ARATH (P43298) Putative receptor protein kinase TMK1 precursor (EC| 2.7.11.1) Length = 942 Score = 80.1 bits (196), Expect = 3e-15 Identities = 51/135 (37%), Positives = 72/135 (53%), Gaps = 3/135 (2%) Frame = +2 Query: 5 EGTVLAILRLPSTSADGAVVVEEGSFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVY 184 +GT +A+ R+ + G E F+ E L +V+HR+L L GY + +LLVY Sbjct: 609 DGTKIAVKRMENGVIAGKGFAE---FKSEIAVLTKVRHRHLVTLLGYCLDG--NEKLLVY 663 Query: 185 DYMPNGNLATLLQEASHQDGHILNWPMRHLIALGVSRGLAFLH---QSGVIHGDVKPQNI 355 +YMP G L+ L E S + L W R +AL V+RG+ +LH IH D+KP NI Sbjct: 664 EYMPQGTLSRHLFEWSEEGLKPLLWKQRLTLALDVARGVEYLHGLAHQSFIHRDLKPSNI 723 Query: 356 LFDADFEPHLSDFGL 400 L D ++DFGL Sbjct: 724 LLGDDMRAKVADFGL 738
>PBS1_ARATH (Q9FE20) Serine/threonine-protein kinase PBS1 (EC 2.7.11.1)| (AvrPphB susceptible protein 1) Length = 456 Score = 79.3 bits (194), Expect = 5e-15 Identities = 56/136 (41%), Positives = 68/136 (50%), Gaps = 3/136 (2%) Frame = +2 Query: 2 SEGTVLAILRLPSTSADGAVVVEEGSFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLV 181 S G V+A+ +L G F E L + H NL L GY A D RLLV Sbjct: 107 STGQVVAVKQLDRNGLQG-----NREFLVEVLMLSLLHHPNLVNLIGYCADG--DQRLLV 159 Query: 182 YDYMPNGNLATLLQEASHQDGHILNWPMRHLIALGVSRGLAFLHQSG---VIHGDVKPQN 352 Y++MP G+L L + D L+W MR IA G ++GL FLH VI+ D K N Sbjct: 160 YEFMPLGSLEDHLHDLP-PDKEALDWNMRMKIAAGAAKGLEFLHDKANPPVIYRDFKSSN 218 Query: 353 ILFDADFEPHLSDFGL 400 IL D F P LSDFGL Sbjct: 219 ILLDEGFHPKLSDFGL 234
>IRAK1_HUMAN (P51617) Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1)| (IRAK-1) Length = 712 Score = 79.3 bits (194), Expect = 5e-15 Identities = 53/132 (40%), Positives = 67/132 (50%), Gaps = 2/132 (1%) Frame = +2 Query: 11 TVLAILRLPSTSADGAVVVEEGSFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDY 190 TV A+ RL +AD + SF E E L R +H N+ GY A LVY + Sbjct: 234 TVYAVKRLKE-NADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGYCA--QNGFYCLVYGF 290 Query: 191 MPNGNLATLLQEASHQDGHILNWPMRHLIALGVSRGLAFLHQSG--VIHGDVKPQNILFD 364 +PNG+L L Q L+WP R I LG +R + FLHQ +IHGD+K N+L D Sbjct: 291 LPNGSLEDRLH-CQTQACPPLSWPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLD 349 Query: 365 ADFEPHLSDFGL 400 P L DFGL Sbjct: 350 ERLTPKLGDFGL 361
>IRAK1_MOUSE (Q62406) Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1)| (IRAK-1) (IRAK) (Pelle-like protein kinase) (mPLK) Length = 710 Score = 78.6 bits (192), Expect = 9e-15 Identities = 52/132 (39%), Positives = 68/132 (51%), Gaps = 2/132 (1%) Frame = +2 Query: 11 TVLAILRLPSTSADGAVVVEEGSFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDY 190 T A+ RL AD + + SF E E L R +H N+ GY A + LVY + Sbjct: 234 TTYAVKRLKE-EADLEWTMVKQSFLTEVEQLSRFRHPNIVDFAGYCA--ESGLYCLVYGF 290 Query: 191 MPNGNLATLLQEASHQDGHILNWPMRHLIALGVSRGLAFLHQSG--VIHGDVKPQNILFD 364 +PNG+L L + Q L+WP R I LG +R + FLHQ +IHGD+K N+L D Sbjct: 291 LPNGSLEDQLHLQT-QACSPLSWPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLD 349 Query: 365 ADFEPHLSDFGL 400 P L DFGL Sbjct: 350 ERLMPKLGDFGL 361
>APK1B_ARATH (P46573) Protein kinase APK1B, chloroplast precursor (EC 2.7.11.1)| Length = 412 Score = 76.6 bits (187), Expect = 3e-14 Identities = 51/134 (38%), Positives = 73/134 (54%), Gaps = 3/134 (2%) Frame = +2 Query: 8 GTVLAILRLPSTSADGAVVVEEGSFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYD 187 G V+A+ +L G + E LG+ H NL L GY + RLLVY+ Sbjct: 101 GVVIAVKKLNQDGWQG-----HQEWLAEVNYLGQFSHPNLVKLIGYCL--EDEHRLLVYE 153 Query: 188 YMPNGNLAT-LLQEASHQDGHILNWPMRHLIALGVSRGLAFLH--QSGVIHGDVKPQNIL 358 +MP G+L L + S+ L+W +R +ALG ++GLAFLH ++ VI+ D K NIL Sbjct: 154 FMPRGSLENHLFRRGSYFQP--LSWTLRLKVALGAAKGLAFLHNAETSVIYRDFKTSNIL 211 Query: 359 FDADFEPHLSDFGL 400 D+++ LSDFGL Sbjct: 212 LDSEYNAKLSDFGL 225
>NORK_MEDTR (Q8L4H4) Nodulation receptor kinase precursor (EC 2.7.11.1) (Does| not make infections protein 2) (Symbiosis receptor-like kinase) (MtSYMRK) Length = 925 Score = 75.5 bits (184), Expect = 7e-14 Identities = 55/135 (40%), Positives = 70/135 (51%), Gaps = 4/135 (2%) Frame = +2 Query: 5 EGTVLAILRLPSTSADGAVVVEEGSFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVY 184 +G +A+ STS G F E L ++H NL L GY D ++LVY Sbjct: 617 DGQEVAVKVRSSTSTQGT-----REFDNELNLLSAIQHENLVPLLGYCN--EYDQQILVY 669 Query: 185 DYMPNGNLATLLQ-EASHQDGHILNWPMRHLIALGVSRGLAFLHQ---SGVIHGDVKPQN 352 +M NG+L L EAS + IL+WP R IALG +RGLA+LH VIH DVK N Sbjct: 670 PFMSNGSLLDRLYGEASKRK--ILDWPTRLSIALGAARGLAYLHTFPGRSVIHRDVKSSN 727 Query: 353 ILFDADFEPHLSDFG 397 IL D ++DFG Sbjct: 728 ILLDQSMCAKVADFG 742
>APK1A_ARATH (Q06548) Protein kinase APK1A, chloroplast precursor (EC 2.7.11.1)| Length = 410 Score = 74.3 bits (181), Expect = 2e-13 Identities = 51/133 (38%), Positives = 70/133 (52%), Gaps = 2/133 (1%) Frame = +2 Query: 8 GTVLAILRLPSTSADGAVVVEEGSFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYD 187 G V+A+ +L G + E LG+ HR+L L GY + RLLVY+ Sbjct: 100 GLVIAVKKLNQDGWQG-----HQEWLAEVNYLGQFSHRHLVKLIGYCL--EDEHRLLVYE 152 Query: 188 YMPNGNLATLLQEASHQDGHILNWPMRHLIALGVSRGLAFLHQS--GVIHGDVKPQNILF 361 +MP G+L L L+W +R +ALG ++GLAFLH S VI+ D K NIL Sbjct: 153 FMPRGSLENHLFRRGLYF-QPLSWKLRLKVALGAAKGLAFLHSSETRVIYRDFKTSNILL 211 Query: 362 DADFEPHLSDFGL 400 D+++ LSDFGL Sbjct: 212 DSEYNAKLSDFGL 224
>IRAK4_MOUSE (Q8R4K2) Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1)| (IRAK-4) Length = 459 Score = 73.2 bits (178), Expect = 4e-13 Identities = 45/108 (41%), Positives = 60/108 (55%), Gaps = 1/108 (0%) Frame = +2 Query: 80 FRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHI-LN 256 F +E + + +H NL L G+ + D LVY YMPNG+L L S DG L+ Sbjct: 230 FDQEIKVMATCQHENLVELLGFSSDS--DNLCLVYAYMPNGSL---LDRLSCLDGTPPLS 284 Query: 257 WPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGL 400 W R +A G + G+ FLH++ IH D+K NIL D DF +SDFGL Sbjct: 285 WHTRCKVAQGTANGIRFLHENHHIHRDIKSANILLDKDFTAKISDFGL 332
>IRAK4_HUMAN (Q9NWZ3) Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1)| (IRAK-4) (NY-REN-64 antigen) Length = 460 Score = 72.8 bits (177), Expect = 5e-13 Identities = 46/108 (42%), Positives = 61/108 (56%), Gaps = 1/108 (0%) Frame = +2 Query: 80 FRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHI-LN 256 F +E + + + +H NL L G+ + D LVY YMPNG+L L S DG L+ Sbjct: 230 FDQEIKVMAKCQHENLVELLGFSSDG--DDLCLVYVYMPNGSL---LDRLSCLDGTPPLS 284 Query: 257 WPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGL 400 W MR IA G + G+ FLH++ IH D+K NIL D F +SDFGL Sbjct: 285 WHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGL 332
>SRK6_BRAOE (Q09092) Putative serine/threonine-protein kinase receptor| precursor (EC 2.7.11.1) (S-receptor kinase) (SRK) Length = 849 Score = 71.6 bits (174), Expect = 1e-12 Identities = 47/135 (34%), Positives = 70/135 (51%), Gaps = 3/135 (2%) Frame = +2 Query: 5 EGTVLAILRLPSTSADGAVVVEEGSFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVY 184 +G +A+ RL TS G F E + R++H NL + G D ++L+Y Sbjct: 549 DGKEIAVKRLSKTSVQGT-----DEFMNEVTLIARLQHINLVQVLGCCI--EGDEKMLIY 601 Query: 185 DYMPNGNLATLLQEASHQDGHILNWPMRHLIALGVSRGLAFLHQSG---VIHGDVKPQNI 355 +Y+ N +L + L + + LNW R I GV+RGL +LHQ +IH D+K NI Sbjct: 602 EYLENLSLDSYLFGKTRRSK--LNWNERFDITNGVARGLLYLHQDSRFRIIHRDLKVSNI 659 Query: 356 LFDADFEPHLSDFGL 400 L D + P +SDFG+ Sbjct: 660 LLDKNMIPKISDFGM 674
>NORK_PEA (Q8LKZ1) Nodulation receptor kinase precursor (EC 2.7.11.1)| Length = 924 Score = 71.6 bits (174), Expect = 1e-12 Identities = 51/134 (38%), Positives = 66/134 (49%), Gaps = 3/134 (2%) Frame = +2 Query: 5 EGTVLAILRLPSTSADGAVVVEEGSFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVY 184 +G +A+ +TS G F E L ++H NL L GY D ++LVY Sbjct: 616 DGQEVAVKVRSATSTQGT-----REFDNELNLLSAIQHENLVPLLGYCN--EYDQQILVY 668 Query: 185 DYMPNGNLATLLQEASHQDGHILNWPMRHLIALGVSRGLAFLHQ---SGVIHGDVKPQNI 355 +M NG+L L IL+WP R IALG +RGLA+LH VIH DVK NI Sbjct: 669 PFMSNGSLLDRLY-GEPAKRKILDWPTRLSIALGAARGLAYLHTFPGRSVIHRDVKSSNI 727 Query: 356 LFDADFEPHLSDFG 397 L D ++DFG Sbjct: 728 LLDHSMCAKVADFG 741
>CRI4_MAIZE (O24585) Putative receptor protein kinase CRINKLY4 precursor (EC| 2.7.11.1) Length = 901 Score = 71.2 bits (173), Expect = 1e-12 Identities = 54/166 (32%), Positives = 74/166 (44%), Gaps = 3/166 (1%) Frame = +2 Query: 5 EGTVLAILRLPSTSADGAVVVEEGSFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVY 184 +GTV+A+ R S V F E + L R+ H +L L GY RLLVY Sbjct: 526 DGTVVAVKRAIKASD---VKKSSKEFHNELDLLSRLNHAHLLNLLGYCEDGSE--RLLVY 580 Query: 185 DYMPNGNLATLLQEASHQDGHILNWPMRHLIALGVSRGLAFLHQSG---VIHGDVKPQNI 355 ++M +G+L L LNW R IA+ +RG+ +LH VIH D+K NI Sbjct: 581 EFMAHGSLYQHLHGKDPNLKKRLNWARRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNI 640 Query: 356 LFDADFEPHLSDFGLEPMVVXXXXXXXXXXXXXXXXXXPVGSLGYV 493 L D D ++DFGL + P G+LGY+ Sbjct: 641 LIDEDHNARVADFGLSIL--------GPADSGTPLSELPAGTLGYL 678
>NAK_ARATH (P43293) Probable serine/threonine-protein kinase NAK (EC 2.7.11.1)| Length = 389 Score = 71.2 bits (173), Expect = 1e-12 Identities = 53/135 (39%), Positives = 71/135 (52%), Gaps = 4/135 (2%) Frame = +2 Query: 8 GTVLAILRLPSTSADGAVVVEEGSFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYD 187 G V+A+ RL G + E LG++ H NL L GY + RLLVY+ Sbjct: 100 GIVIAVKRLNQEGFQG-----HREWLAEINYLGQLDHPNLVKLIGYCL--EEEHRLLVYE 152 Query: 188 YMPNGNLATLL--QEASHQDGHILNWPMRHLIALGVSRGLAFLH--QSGVIHGDVKPQNI 355 +M G+L L + +Q L+W R +ALG +RGLAFLH Q VI+ D K NI Sbjct: 153 FMTRGSLENHLFRRGTFYQP---LSWNTRVRMALGAARGLAFLHNAQPQVIYRDFKASNI 209 Query: 356 LFDADFEPHLSDFGL 400 L D+++ LSDFGL Sbjct: 210 LLDSNYNAKLSDFGL 224
>KPEL_DROME (Q05652) Probable serine/threonine-protein kinase pelle (EC| 2.7.11.1) Length = 501 Score = 70.5 bits (171), Expect = 2e-12 Identities = 47/134 (35%), Positives = 69/134 (51%), Gaps = 6/134 (4%) Frame = +2 Query: 17 LAILRLPSTSADGAVVVEEGSFRKEAESLGRVKHRNLTVLRGYY--AGPPPDVRLLVYDY 190 + ++ S + D +V + S+ E + L ++H N+ L GY G P LVY Sbjct: 239 IKVMNYRSPNIDQKMVELQQSYN-ELKYLNSIRHDNILALYGYSIKGGKP----CLVYQL 293 Query: 191 MPNGNLATLLQEASHQDG-HILNWPMRHLIALGVSRGLAFLHQSG---VIHGDVKPQNIL 358 M G+L L+ Q+ L W R I+LG +RG+ FLH + +IHGD+KP NIL Sbjct: 294 MKGGSLEARLRAHKAQNPLPALTWQQRFSISLGTARGIYFLHTARGTPLIHGDIKPANIL 353 Query: 359 FDADFEPHLSDFGL 400 D +P + DFGL Sbjct: 354 LDQCLQPKIGDFGL 367
>SIRK_ARATH (O64483) Senescence-induced receptor-like serine/threonine-protein| kinase precursor (FLG22-induced receptor-like kinase 1) Length = 876 Score = 69.7 bits (169), Expect = 4e-12 Identities = 49/134 (36%), Positives = 69/134 (51%), Gaps = 3/134 (2%) Frame = +2 Query: 8 GTVLAILRLPSTSADGAVVVEEGSFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYD 187 G +A+ L SA G FR E + L RV H NLT L GY + +L+Y+ Sbjct: 595 GEQVAVKVLSEESAQGYK-----EFRAEVDLLMRVHHTNLTSLVGYCN--EINHMVLIYE 647 Query: 188 YMPNGNLATLLQEASHQDGHILNWPMRHLIALGVSRGLAFLHQS---GVIHGDVKPQNIL 358 YM N NL L + + IL+W R I+L ++GL +LH ++H DVKP NIL Sbjct: 648 YMANENLGDYL---AGKRSFILSWEERLKISLDAAQGLEYLHNGCKPPIVHRDVKPTNIL 704 Query: 359 FDADFEPHLSDFGL 400 + + ++DFGL Sbjct: 705 LNEKLQAKMADFGL 718
>RLCK7_ARATH (Q9LQQ8) Probable serine/threonine-protein kinase RLCKVII (EC| 2.7.11.1) Length = 423 Score = 69.3 bits (168), Expect = 5e-12 Identities = 52/132 (39%), Positives = 65/132 (49%), Gaps = 3/132 (2%) Frame = +2 Query: 14 VLAILRLPSTSADGAVVVEEGSFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYM 193 V+AI +L G F E +L H NL L G+ A D RLLVY+YM Sbjct: 128 VVAIKQLDRNGVQGI-----REFVVEVLTLSLADHPNLVKLIGFCA--EGDQRLLVYEYM 180 Query: 194 PNGNLATLLQEASHQDGHILNWPMRHLIALGVSRGLAFLHQS---GVIHGDVKPQNILFD 364 P G+L L L+W R IA G +RGL +LH VI+ D+K NIL Sbjct: 181 PQGSLEDHLHVLP-SGKKPLDWNTRMKIAAGAARGLEYLHDRMTPPVIYRDLKCSNILLG 239 Query: 365 ADFEPHLSDFGL 400 D++P LSDFGL Sbjct: 240 EDYQPKLSDFGL 251
>UHMK1_RAT (Q63285) Serine/threonine-protein kinase Kist (EC 2.7.11.1) (Kinase| interacting with stathmin) (U2AF homology motif kinase 1) (PAM COOH-terminal interactor protein 2) (P-CIP2) Length = 419 Score = 61.2 bits (147), Expect = 1e-09 Identities = 46/128 (35%), Positives = 69/128 (53%), Gaps = 5/128 (3%) Frame = +2 Query: 32 LPSTSADGAVVVEEGSFRKEAESLGRVK-HRNLTVLRGYYA---GPPPDVRLLVYDYMPN 199 LP + A E FRKE +L +++ HRN+ L G + P R L+ + + + Sbjct: 57 LPPGTTGAAASAAEYGFRKERAALEQLQGHRNIVTLYGVFTIHFSPNVPSRCLLLELL-D 115 Query: 200 GNLATLLQEASHQDGHILNWPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEP 379 +++ LL +SHQ + W ++H A V LAFLH G +H D+KP+NIL+ A+ E Sbjct: 116 VSVSELLVYSSHQGCSM--WMIQHC-ARDVLEALAFLHHEGYVHADLKPRNILWSAENEC 172 Query: 380 -HLSDFGL 400 L DFGL Sbjct: 173 FKLIDFGL 180
>UHMK1_MOUSE (P97343) Serine/threonine-protein kinase Kist (EC 2.7.11.1) (Kinase| interacting with stathmin) (U2AF homology motif kinase 1) Length = 419 Score = 61.2 bits (147), Expect = 1e-09 Identities = 46/128 (35%), Positives = 69/128 (53%), Gaps = 5/128 (3%) Frame = +2 Query: 32 LPSTSADGAVVVEEGSFRKEAESLGRVK-HRNLTVLRGYYA---GPPPDVRLLVYDYMPN 199 LP + A E FRKE +L +++ HRN+ L G + P R L+ + + + Sbjct: 57 LPPGTTGAAASAAEYGFRKERAALEQLQGHRNIVTLYGVFTIHFSPNVPSRCLLLELL-D 115 Query: 200 GNLATLLQEASHQDGHILNWPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEP 379 +++ LL +SHQ + W ++H A V LAFLH G +H D+KP+NIL+ A+ E Sbjct: 116 VSVSELLLYSSHQGCSM--WMIQHC-ARDVLEALAFLHHEGYVHADLKPRNILWSAENEC 172 Query: 380 -HLSDFGL 400 L DFGL Sbjct: 173 FKLIDFGL 180
>UHMK1_HUMAN (Q8TAS1) Serine/threonine-protein kinase Kist (EC 2.7.11.1) (Kinase| interacting with stathmin) (U2AF homology motif kinase 1) Length = 419 Score = 61.2 bits (147), Expect = 1e-09 Identities = 46/128 (35%), Positives = 69/128 (53%), Gaps = 5/128 (3%) Frame = +2 Query: 32 LPSTSADGAVVVEEGSFRKEAESLGRVK-HRNLTVLRGYYA---GPPPDVRLLVYDYMPN 199 LP + A E FRKE +L +++ HRN+ L G + P R L+ + + + Sbjct: 57 LPPGTTGAAASAAEYGFRKERAALEQLQGHRNIVTLYGVFTIHFSPNVPSRCLLLELL-D 115 Query: 200 GNLATLLQEASHQDGHILNWPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEP 379 +++ LL +SHQ + W ++H A V LAFLH G +H D+KP+NIL+ A+ E Sbjct: 116 VSVSELLLYSSHQGCSM--WMIQHC-ARDVLEALAFLHHEGYVHADLKPRNILWSAENEC 172 Query: 380 -HLSDFGL 400 L DFGL Sbjct: 173 FKLIDFGL 180
>HT1_ARATH (Q2MHE4) Serine/threonine-protein kinase HT1 (EC 2.7.11.1) (High| leaf temperature protein 1) Length = 390 Score = 60.5 bits (145), Expect = 2e-09 Identities = 37/125 (29%), Positives = 65/125 (52%) Frame = +2 Query: 23 ILRLPSTSADGAVVVEEGSFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNG 202 ++R+P+ + +E+ F+ E L R+ H N+ PP V ++ +YM G Sbjct: 114 MVRIPTHKEETRAKLEQ-QFKSEVALLSRLFHPNIVQFIAACKKPP--VYCIITEYMSQG 170 Query: 203 NLATLLQEASHQDGHILNWPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPH 382 NL L + ++ + L+ +AL +SRG+ +LH GVIH D+K N+L + + Sbjct: 171 NLRMYLNK---KEPYSLSIETVLRLALDISRGMEYLHSQGVIHRDLKSNNLLLNDEMRVK 227 Query: 383 LSDFG 397 ++DFG Sbjct: 228 VADFG 232
>RIPK2_MOUSE (P58801) Receptor-interacting serine/threonine-protein kinase 2 (EC| 2.7.11.1) Length = 539 Score = 58.2 bits (139), Expect = 1e-08 Identities = 36/113 (31%), Positives = 58/113 (51%), Gaps = 2/113 (1%) Frame = +2 Query: 68 EEGSFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGH 247 E +EAE L + + + + G P+ +V +YMPNG+L LL + Sbjct: 59 ERNDILREAEILHKARFSYILPILGICN--EPEFLGIVTEYMPNGSLNELLHRKTEYPD- 115 Query: 248 ILNWPMRHLIALGVSRGLAFLHQSG--VIHGDVKPQNILFDADFEPHLSDFGL 400 + WP+R I ++ G+ +LH ++H D+K QNIL D +F ++DFGL Sbjct: 116 -IAWPLRFRILHEIALGVNYLHNMNPPLLHHDLKTQNILLDNEFHVKIADFGL 167
>SPK1_DUGTI (P42687) Tyrosine-protein kinase SPK-1 (EC 2.7.10.2)| Length = 497 Score = 57.4 bits (137), Expect = 2e-08 Identities = 37/112 (33%), Positives = 58/112 (51%), Gaps = 1/112 (0%) Frame = +2 Query: 68 EEGSFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGH 247 E F EA+ + +++HR + L G P L++ +YM NG+L L+ DG Sbjct: 256 EREKFVLEAKIMHKLRHRKIVELLGVCTEPQDMPMLIIVEYMKNGSLKEYLKTP---DGK 312 Query: 248 ILNW-PMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGL 400 N M H++A +S G+A+L V+H D++ NIL D ++DFGL Sbjct: 313 KTNLNQMVHMMA-EISEGMAYLESEKVVHRDLRADNILVANDLTRKVADFGL 363
>RIPK1_HUMAN (Q13546) Receptor-interacting serine/threonine-protein kinase 1 (EC| 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein) Length = 671 Score = 56.6 bits (135), Expect = 4e-08 Identities = 36/107 (33%), Positives = 56/107 (52%), Gaps = 2/107 (1%) Frame = +2 Query: 86 KEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHILNWPM 265 +EA+ + R++H + L G LV +YM GNL +L+ ++ P+ Sbjct: 62 EEAKMMNRLRHSRVVKLLGVII--EEGKYSLVMEYMEKGNLMHVLKAE-------MSTPL 112 Query: 266 --RHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGL 400 + I L + G+ +LH GVIH D+KP+NIL D DF ++D GL Sbjct: 113 SVKGRIILEIIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGL 159
>PKNL_MYCTU (O53510) Probable serine/threonine-protein kinase pknL (EC| 2.7.11.1) Length = 399 Score = 56.2 bits (134), Expect = 5e-08 Identities = 37/107 (34%), Positives = 55/107 (51%) Frame = +2 Query: 80 FRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHILNW 259 FR EA ++ R+ +R L + Y G LV + + G L LL E H + Sbjct: 64 FRLEARAVARLNNRALVAV--YDQGKDGRHPFLVMELIEGGTLRELLIERGPMPPHAVVA 121 Query: 260 PMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGL 400 +R ++ GLA H++G++H DVKP+NIL D + L+DFGL Sbjct: 122 VLRPVLG-----GLAAAHRAGLVHRDVKPENILISDDGDVKLADFGL 163
>PKNL_MYCBO (Q7TYY6) Probable serine/threonine-protein kinase pknL (EC| 2.7.11.1) Length = 399 Score = 56.2 bits (134), Expect = 5e-08 Identities = 37/107 (34%), Positives = 55/107 (51%) Frame = +2 Query: 80 FRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHILNW 259 FR EA ++ R+ +R L + Y G LV + + G L LL E H + Sbjct: 64 FRLEARAVARLNNRALVAV--YDQGKDGRHPFLVMELIEGGTLRELLIERGPMPPHAVVA 121 Query: 260 PMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGL 400 +R ++ GLA H++G++H DVKP+NIL D + L+DFGL Sbjct: 122 VLRPVLG-----GLAAAHRAGLVHRDVKPENILISDDGDVKLADFGL 163
>AURKC_MOUSE (O88445) Serine/threonine-protein kinase 13 (EC 2.7.11.1)| (Aurora/Ipl1/Eg2 protein 1) (Aurora-C) Length = 282 Score = 56.2 bits (134), Expect = 5e-08 Identities = 38/110 (34%), Positives = 55/110 (50%), Gaps = 1/110 (0%) Frame = +2 Query: 71 EGSFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRL-LVYDYMPNGNLATLLQEASHQDGH 247 E R+E E ++HRN+ L Y+ D R+ L+ +Y P G L LQ HQ Sbjct: 58 EHQLRREVEIQAHLQHRNILRLYNYFYD---DTRIYLILEYAPGGELYKELQR--HQK-- 110 Query: 248 ILNWPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFG 397 L+ I +S L + H+ VIH D+KP+N+L + E +SDFG Sbjct: 111 -LDQQRTATIIQELSDALTYCHEKKVIHRDIKPENLLLGLNGEVKISDFG 159
>ROR1_DROME (Q24488) Tyrosine-protein kinase transmembrane receptor Ror| precursor (EC 2.7.10.1) (dRor) Length = 685 Score = 56.2 bits (134), Expect = 5e-08 Identities = 34/117 (29%), Positives = 58/117 (49%) Frame = +2 Query: 50 DGAVVVEEGSFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEA 229 + A V + F++E E + +KH+N+ + G P ++++YM NG+L L Sbjct: 446 ENASVKTQQDFKREIELISDLKHQNIVCILGVVLNKEP--YCMLFEYMANGDLHEFLISN 503 Query: 230 SHQDGHILNWPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGL 400 S +G L+ IAL +S G+ +L +H D+ +N L + +SDFGL Sbjct: 504 SPTEGKSLSQLEFLQIALQISEGMQYLSAHHYVHRDLAARNCLVNEGLVVKISDFGL 560
>RIPK2_HUMAN (O43353) Receptor-interacting serine/threonine-protein kinase 2 (EC| 2.7.11.1) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (CARD-containing interleukin-1 beta-converting enzyme-associated kinase) (CARD-containi Length = 540 Score = 55.8 bits (133), Expect = 6e-08 Identities = 35/107 (32%), Positives = 57/107 (53%), Gaps = 2/107 (1%) Frame = +2 Query: 86 KEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHILNWPM 265 +EAE L + + + + G P+ +V +YMPNG+L LL + + WP+ Sbjct: 65 REAEILHKARFSYILPILGICN--EPEFLGIVTEYMPNGSLNELLHRKTEYPD--VAWPL 120 Query: 266 RHLIALGVSRGLAFLHQSG--VIHGDVKPQNILFDADFEPHLSDFGL 400 R I ++ G+ +LH ++H D+K QNIL D +F ++DFGL Sbjct: 121 RFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGL 167
>RIPK3_RAT (Q9Z2P5) Receptor-interacting serine/threonine-protein kinase 3 (EC| 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) (Homocysteine respondent protein HCYP2) Length = 478 Score = 55.5 bits (132), Expect = 8e-08 Identities = 36/123 (29%), Positives = 60/123 (48%), Gaps = 10/123 (8%) Frame = +2 Query: 62 VVEEGSFRKEAESLGRVKHRNLTVLRG--------YYAGPPPDVRLLVYDYMPNGNLATL 217 +V +E +++ ++H N+ +L G Y GP LV +M NG+L+ L Sbjct: 52 IVNSKKISREVKAMVNLRHENVLLLLGVTENLEWDYVYGPA-----LVTGFMENGSLSGL 106 Query: 218 LQEASHQDGHILNWPMRHLIALGVSRGLAFLHQ--SGVIHGDVKPQNILFDADFEPHLSD 391 LQ + + WP+ + V G+ +LH ++H D+KP N+L D + L+D Sbjct: 107 LQPSCPRP-----WPLLCRLLEEVVLGMCYLHSLNPSLLHRDLKPSNVLLDLELHAKLAD 161 Query: 392 FGL 400 FGL Sbjct: 162 FGL 164
>RIPK1_MOUSE (Q60855) Receptor-interacting serine/threonine-protein kinase 1 (EC| 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein) Length = 656 Score = 55.5 bits (132), Expect = 8e-08 Identities = 36/122 (29%), Positives = 57/122 (46%) Frame = +2 Query: 35 PSTSADGAVVVEEGSFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLAT 214 P+ + V++EEG VK + + G Y+ LV +YM GNL Sbjct: 51 PNRAEYNEVLLEEGKMMHRLRHSRVVKLLGIIIEEGNYS--------LVMEYMEKGNLMH 102 Query: 215 LLQEASHQDGHILNWPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDF 394 +L+ + ++ I + G+ +LH GVIH D+KP+NIL D DF ++D Sbjct: 103 VLKTQID-----VPLSLKGRIIVEAIEGMCYLHDKGVIHKDLKPENILVDRDFHIKIADL 157 Query: 395 GL 400 G+ Sbjct: 158 GV 159
>RIM15_YEAST (P43565) Serine/threonine-protein kinase RIM15 (EC 2.7.11.1)| Length = 1770 Score = 55.1 bits (131), Expect = 1e-07 Identities = 30/79 (37%), Positives = 47/79 (59%) Frame = +2 Query: 164 DVRLLVYDYMPNGNLATLLQEASHQDGHILNWPMRHLIALGVSRGLAFLHQSGVIHGDVK 343 D LV +Y+P G+LATL++ + W ++L + V G+ +HQ+G+IH D+K Sbjct: 866 DNLFLVMEYLPGGDLATLIKMMGYLPDQ---WAKQYLTEIVV--GVNDMHQNGIIHHDLK 920 Query: 344 PQNILFDADFEPHLSDFGL 400 P+N+L D L+DFGL Sbjct: 921 PENLLIDNAGHVKLTDFGL 939
>IRAK3_HUMAN (Q9Y616) Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1)| (IRAK-3) (IL-1 receptor-associated kinase M) (IRAK-M) Length = 596 Score = 54.7 bits (130), Expect = 1e-07 Identities = 38/110 (34%), Positives = 52/110 (47%), Gaps = 3/110 (2%) Frame = +2 Query: 80 FRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHILNW 259 F E E L H N+ L Y+ + L+Y YM NG L LQ D L W Sbjct: 209 FLSELEVLLLFHHPNILELAAYFT--ETEKFCLIYPYMRNGTLFDRLQCVG--DTAPLPW 264 Query: 260 PMRHLIALGVSRGLAFLHQ---SGVIHGDVKPQNILFDADFEPHLSDFGL 400 +R I +G+S+ + +LH VI G + NIL D F+P L+DF + Sbjct: 265 HIRIGILIGISKAIHYLHNVQPCSVICGSISSANILLDDQFQPKLTDFAM 314
>IPL1_ASHGO (Q755C4) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) Length = 367 Score = 54.7 bits (130), Expect = 1e-07 Identities = 33/110 (30%), Positives = 60/110 (54%), Gaps = 1/110 (0%) Frame = +2 Query: 71 EGSFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRL-LVYDYMPNGNLATLLQEASHQDGH 247 E FR+E E ++H NLT L GY+ + R+ L+ +Y+ NG L L+ SH + Sbjct: 151 EKQFRREVEIQSSLRHPNLTQLYGYFHD---EKRVYLLMEYLVNGELYKHLKGRSHFNDV 207 Query: 248 ILNWPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFG 397 + ++ + + + L ++H+ ++H D+KP+NI+ + L+DFG Sbjct: 208 VASYYVYQM-----ADALDYMHERNILHRDIKPENIIIGFNNTIKLTDFG 252
>IRAK2_HUMAN (O43187) Interleukin-1 receptor-associated kinase-like 2 (IRAK-2)| Length = 590 Score = 53.9 bits (128), Expect = 2e-07 Identities = 38/121 (31%), Positives = 57/121 (47%) Frame = +2 Query: 26 LRLPSTSADGAVVVEEGSFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGN 205 LR + S+ G++ E F+ E + R H N+ + G+ A +Y YM NG+ Sbjct: 239 LRETACSSPGSI---ERFFQAELQICLRCCHPNVLPVLGFCAAR--QFHSFIYPYMANGS 293 Query: 206 LATLLQEASHQDGHILNWPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHL 385 L LQ D L WP R I G+ + +LH +IH +VK N+L D + P L Sbjct: 294 LQDRLQGQGGSDP--LPWPQRVSICSGLLCAVEYLHGLEIIHSNVKSSNVLLDQNLTPKL 351 Query: 386 S 388 + Sbjct: 352 A 352
>TESK1_HUMAN (Q15569) Dual specificity testis-specific protein kinase 1 (EC| 2.7.12.1) (Testicular protein kinase 1) Length = 626 Score = 53.9 bits (128), Expect = 2e-07 Identities = 41/132 (31%), Positives = 60/132 (45%), Gaps = 3/132 (2%) Frame = +2 Query: 14 VLAILRLPSTSADGAVVVEEGSFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYM 193 VL + +LPS G+ +E + + R++H N+ G L +YM Sbjct: 84 VLKMNKLPSN---------RGNTLREVQLMNRLRHPNILRFMGVCVHQGQLHALT--EYM 132 Query: 194 PNGNLATLLQEASHQDGHILNWPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILF---D 364 G L LL L+WP+R +AL ++RGL +LH GV H D+ +N L D Sbjct: 133 NGGTLEQLLSSPEP-----LSWPVRLHLALDIARGLRYLHSKGVFHRDLTSKNCLVRRED 187 Query: 365 ADFEPHLSDFGL 400 F + DFGL Sbjct: 188 RGFTAVVGDFGL 199
>IPL1_CANAL (Q59S66) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) Length = 530 Score = 53.9 bits (128), Expect = 2e-07 Identities = 37/109 (33%), Positives = 53/109 (48%) Frame = +2 Query: 71 EGSFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHI 250 E S R+E E + H N+T L ++ LL +Y G L T L++ D Sbjct: 286 EKSLRREIEIQSNLYHINITRLYSWFHDSINIYLLL--EYSIEGELYTHLKKLKRFDNI- 342 Query: 251 LNWPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFG 397 M +++ L FLHQ G+IH D+KP+NI+ D + LSDFG Sbjct: 343 ----MASNYIFQITQALIFLHQRGIIHRDLKPENIMISLDNQLKLSDFG 387
>GUC2G_MOUSE (Q6TL19) Guanylate cyclase 2G precursor (EC 4.6.1.2) (Guanylyl| cyclase receptor G) (mGC-G) Length = 1100 Score = 53.9 bits (128), Expect = 2e-07 Identities = 34/113 (30%), Positives = 57/113 (50%), Gaps = 1/113 (0%) Frame = +2 Query: 65 VEEGSFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDG 244 V++ + R+E + +KH N+ G PP +V Y G+L +++ + H+ Sbjct: 595 VKKPTVRREVCLMCELKHENIVPFFGVCTEPPNIC--IVTQYCKKGSLQDVMRNSDHE-- 650 Query: 245 HILNWPMRHLIALGVSRGLAFLHQSGV-IHGDVKPQNILFDADFEPHLSDFGL 400 ++W + A + GL FLH S + HG++KP N L D+ + LS FGL Sbjct: 651 --IDWIFKLSFAYDIVNGLLFLHGSPLRSHGNLKPSNCLVDSHMQLKLSGFGL 701
>PKN2_CLOPE (Q8XJL8) Probable serine/threonine protein kinase CPE1738 (EC| 2.7.11.1) Length = 685 Score = 53.5 bits (127), Expect = 3e-07 Identities = 32/107 (29%), Positives = 56/107 (52%) Frame = +2 Query: 80 FRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHILNW 259 F+KEA ++ + + N V+ G D+ +V +Y+ L +++E L + Sbjct: 55 FKKEATAIANLSNPN--VVNVLDVGTQDDINYIVMEYVEGKTLKDIIKEKG-----ALPY 107 Query: 260 PMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGL 400 + I + V++ L H+SG+IH DVKPQNIL + ++DFG+ Sbjct: 108 EVAISIGIKVAKALECAHKSGIIHRDVKPQNILVTEEGVVKVTDFGI 154
>EPHA3_MOUSE (P29319) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ETK1) (MEK4) Length = 983 Score = 53.5 bits (127), Expect = 3e-07 Identities = 32/109 (29%), Positives = 58/109 (53%), Gaps = 2/109 (1%) Frame = +2 Query: 80 FRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHILNW 259 F EA +G+ H N+ L G P+ ++V +YM NG+L + L++ H + Sbjct: 667 FLGEASIMGQFDHPNIIRLEGVVTKSKPE--MIVTEYMENGSLDSFLRK------HDAQF 718 Query: 260 PMRHLIAL--GVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGL 400 + L+ + G++ G+ +L G +H D+ +NIL +++ +SDFGL Sbjct: 719 TVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGL 767
>STK6_XENLA (Q91820) Serine/threonine-protein kinase Eg2 (EC 2.7.11.1) (pEg2)| (p46Eg265) Length = 407 Score = 53.1 bits (126), Expect = 4e-07 Identities = 33/109 (30%), Positives = 52/109 (47%) Frame = +2 Query: 71 EGSFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHI 250 E R+E E ++H N+ L GY+ L+ DY P G L LQ+ + D Sbjct: 182 EHQLRREVEIQSHLRHPNILRLYGYFHDASRVY--LILDYAPGGELFRELQKCTRFDDQR 239 Query: 251 LNWPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFG 397 ++ L + L + H VIH D+KP+N+L ++ E ++DFG Sbjct: 240 SAMYIKQL-----AEALLYCHSKKVIHRDIKPENLLLGSNGELKIADFG 283
>EPHA5_HUMAN (P54756) Ephrin type-A receptor 5 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Receptor protein-tyrosine kinase HEK7) Length = 1037 Score = 53.1 bits (126), Expect = 4e-07 Identities = 34/109 (31%), Positives = 57/109 (52%), Gaps = 2/109 (1%) Frame = +2 Query: 80 FRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHILNW 259 F EA +G+ H N+ L G P ++V +YM NG+L T L++ Q + Sbjct: 721 FLGEASIMGQFDHPNIIHLEGVVTKSKPV--MIVTEYMENGSLDTFLKKNDGQ------F 772 Query: 260 PMRHLIAL--GVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGL 400 + L+ + G+S G+ +L G +H D+ +NIL +++ +SDFGL Sbjct: 773 TVIQLVGMLRGISAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGL 821
>LATS2_HUMAN (Q9NRM7) Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Large| tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Kinase phosphorylated during mitosis protein) (Warts-like kinase) Length = 1088 Score = 52.8 bits (125), Expect = 5e-07 Identities = 31/93 (33%), Positives = 47/93 (50%) Frame = +2 Query: 122 NLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHILNWPMRHLIALGVSRGL 301 N V++ YY+ D V DY+P G++ +LL H+ + + L + + Sbjct: 725 NEWVVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIRMEVFPEHLARFYIAEL-----TLAI 779 Query: 302 AFLHQSGVIHGDVKPQNILFDADFEPHLSDFGL 400 +H+ G IH D+KP NIL D D L+DFGL Sbjct: 780 ESVHKMGFIHRDIKPDNILIDLDGHIKLTDFGL 812
>YR831_MIMIV (Q7T6Y2) Putative serine/threonine-protein kinase/receptor R831| precursor (EC 2.7.11.1) Length = 1624 Score = 52.8 bits (125), Expect = 5e-07 Identities = 32/110 (29%), Positives = 58/110 (52%) Frame = +2 Query: 71 EGSFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHI 250 E SF +E + + ++H N+ + P +V ++M G+L LL + Sbjct: 825 ERSFFEEVKIMTSLRHPNVVLFMAASTKSPN--MCIVMEFMSLGSLYDLLGNELIPE--- 879 Query: 251 LNWPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGL 400 + + ++ +A S+G+ FLH SG++H D+K N+L D+ + +SDFGL Sbjct: 880 IPYALKIKMAYQASKGMHFLHSSGIVHRDLKSLNLLLDSKWNVKVSDFGL 929 Score = 52.0 bits (123), Expect = 9e-07 Identities = 33/108 (30%), Positives = 52/108 (48%), Gaps = 2/108 (1%) Frame = +2 Query: 80 FRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHILNW 259 FR E L +KH N+ G P +V +YM GNL +L+ + + + Sbjct: 1406 FRAEMAFLSELKHSNIVTFIGACIKKPNIC--IVTEYMRMGNLRDVLKNPDIK----ITF 1459 Query: 260 PMRHLIALGVSRGLAFLHQSG--VIHGDVKPQNILFDADFEPHLSDFG 397 + + G + G+ +LH S ++H D+KP NIL D F ++DFG Sbjct: 1460 ANKLKLLYGAAMGIDYLHSSNPMIVHRDIKPANILVDEHFNVKIADFG 1507
>EPHA5_RAT (P54757) Ephrin type-A receptor 5 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) Length = 1005 Score = 52.8 bits (125), Expect = 5e-07 Identities = 33/109 (30%), Positives = 57/109 (52%), Gaps = 2/109 (1%) Frame = +2 Query: 80 FRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHILNW 259 F EA +G+ H N+ L G P ++V +YM NG+L T L++ Q + Sbjct: 723 FLSEASIMGQFDHPNIIHLEGVVTKSKPV--MIVTEYMENGSLDTFLKKNDGQ------F 774 Query: 260 PMRHLIAL--GVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGL 400 + L+ + G++ G+ +L G +H D+ +NIL +++ +SDFGL Sbjct: 775 TVIQLVGMLRGIAAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGL 823
>IRAK3_MOUSE (Q8K4B2) Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1)| (IRAK-3) (IL-1 receptor-associated kinase M) (IRAK-M) Length = 609 Score = 52.8 bits (125), Expect = 5e-07 Identities = 35/108 (32%), Positives = 54/108 (50%), Gaps = 3/108 (2%) Frame = +2 Query: 80 FRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHILNW 259 F E E L +H ++ L Y+ + LVY YM NG L LQ + L+W Sbjct: 222 FLSELEVLLLFRHPHILELAAYFT--ETEKLCLVYPYMSNGTLFDRLQCTNGTTP--LSW 277 Query: 260 PMRHLIALGVSRGLAFLHQS---GVIHGDVKPQNILFDADFEPHLSDF 394 +R + +G+++ + +LH + VI G+V NIL D +P L+DF Sbjct: 278 HVRISVLIGIAKAIQYLHNTQPCAVICGNVSSANILLDDQLQPKLTDF 325
>LATS2_MOUSE (Q7TSJ6) Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Large| tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Kinase phosphorylated during mitosis protein) Length = 1042 Score = 52.8 bits (125), Expect = 5e-07 Identities = 31/93 (33%), Positives = 47/93 (50%) Frame = +2 Query: 122 NLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHILNWPMRHLIALGVSRGL 301 N V++ YY+ D V DY+P G++ +LL H+ + + L + + Sbjct: 683 NEWVVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIRMEVFPEHLARFYIAEL-----TLAI 737 Query: 302 AFLHQSGVIHGDVKPQNILFDADFEPHLSDFGL 400 +H+ G IH D+KP NIL D D L+DFGL Sbjct: 738 ESVHKMGFIHRDIKPDNILIDLDGHIKLTDFGL 770
>ICL1_KLULA (Q6CWQ4) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) Length = 361 Score = 52.8 bits (125), Expect = 5e-07 Identities = 33/106 (31%), Positives = 50/106 (47%) Frame = +2 Query: 80 FRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHILNW 259 FR+E E G KH+NLT L G++ L+ Y Y G L L+ LN Sbjct: 145 FRREVEIQGSFKHKNLTQLYGFFYDEKRVYLLMEYVYY--GELYKFLKNNGP-----LNE 197 Query: 260 PMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFG 397 + ++ L ++H ++H D+KP+NIL + L+DFG Sbjct: 198 TLASYFVYQMANALDYMHSKNILHRDIKPENILIGFNNTIKLTDFG 243
>STK6L_XENLA (Q91819) Serine/threonine-protein kinase Eg2-like (EC 2.7.11.1)| (p46XlEg22) Length = 408 Score = 52.8 bits (125), Expect = 5e-07 Identities = 33/109 (30%), Positives = 52/109 (47%) Frame = +2 Query: 71 EGSFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHI 250 E R+E E ++H N+ L GY+ L+ DY P G L LQ+ + D Sbjct: 182 EHQLRREVEIQSHLRHPNILRLYGYFHDASRVY--LILDYAPGGELFRELQKCTRFDDQR 239 Query: 251 LNWPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFG 397 ++ L + L + H VIH D+KP+N+L ++ E ++DFG Sbjct: 240 SALYIKQL-----AEALLYCHSKKVIHRDIKPENLLLGSNGELKIADFG 283
>BCK1_YEAST (Q01389) Serine/threonine-protein kinase BCK1/SLK1/SSP31 (EC| 2.7.11.1) Length = 1478 Score = 52.4 bits (124), Expect = 7e-07 Identities = 33/120 (27%), Positives = 62/120 (51%) Frame = +2 Query: 41 TSADGAVVVEEGSFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLL 220 +S + A++ + R E +L + H N+ G+ ++ L +Y+ G++ +L+ Sbjct: 1212 SSQNEAILSTVEALRSEVSTLKDLDHLNIVQYLGFEN--KNNIYSLFLEYVAGGSVGSLI 1269 Query: 221 QEASHQDGHILNWPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGL 400 + D ++ +HL V +GLA+LH G++H D+K N+L D D +SDFG+ Sbjct: 1270 RMYGRFDEPLI----KHLTTQ-VLKGLAYLHSKGILHRDMKADNLLLDQDGICKISDFGI 1324
>VAB1_CAEEL (O61460) Ephrin receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein| kinase Eph receptor) (Variable abnormal protein 1) Length = 1122 Score = 52.4 bits (124), Expect = 7e-07 Identities = 34/125 (27%), Positives = 58/125 (46%), Gaps = 5/125 (4%) Frame = +2 Query: 41 TSADGAVVVEEGSFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLL 220 T G+ + F EA +G+ H N+ L G P ++V +YM NG+L L Sbjct: 749 TLKSGSSAKAKAEFLTEATIMGQFSHPNVIRLIGVVTSAEPV--MIVAEYMANGSLDQFL 806 Query: 221 QEASHQDGHILNWPMRHLIALGVSRGLAFLHQSGVIHG-----DVKPQNILFDADFEPHL 385 + Q G ++W + G++ G+ +L G +H D+ +N+L D + + Sbjct: 807 RNTD-QRGEKVHWEKITEMLYGIASGMKYLTDMGYVHRVSFLRDLAARNVLLDMELRCKI 865 Query: 386 SDFGL 400 +DFGL Sbjct: 866 ADFGL 870
>PKH3_YEAST (Q03306) Serine/threonine-protein kinase PKH3 (EC 2.7.11.1)| (Pkb-activating kinase homolog 3) Length = 898 Score = 52.4 bits (124), Expect = 7e-07 Identities = 34/107 (31%), Positives = 53/107 (49%) Frame = +2 Query: 77 SFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHILN 256 + K +L KH + +++ YY + V D+ P G L +LL H+ G + Sbjct: 58 TIEKNTMNLLAQKH-HAGIIKLYYTFHDEENLYFVLDFAPGGELLSLL----HKMGTFND 112 Query: 257 WPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFG 397 RH A + L F+H G+IH D+KP+N+L D D ++DFG Sbjct: 113 IWTRHFTAQLID-ALEFIHSHGIIHRDLKPENVLLDRDGRLMITDFG 158
>SSK22_YEAST (P25390) Serine/threonine-protein kinase SSK22 (EC 2.7.11.1) (MAP| kinase kinase kinase SSK22) (Suppressor of sensor kinase 22) Length = 1331 Score = 52.0 bits (123), Expect = 9e-07 Identities = 36/111 (32%), Positives = 55/111 (49%) Frame = +2 Query: 83 RKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHILNWP 262 ++E L + H N +++ Y D + +Y G+LA+LL G I + Sbjct: 1081 KEEMTVLEMLNHPN--IVQYYGVEVHRDKVNIFMEYCEGGSLASLLDH-----GRIEDEM 1133 Query: 263 MRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGLEPMVV 415 + + + GLA+LHQSGV+H D+KP+NIL D + DFG VV Sbjct: 1134 VTQVYTFELLEGLAYLHQSGVVHRDIKPENILLDFNGIIKYVDFGTARTVV 1184
>EPHA5_MOUSE (Q60629) Ephrin type-A receptor 5 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Brain-specific kinase) (CEK-7) Length = 877 Score = 52.0 bits (123), Expect = 9e-07 Identities = 33/109 (30%), Positives = 57/109 (52%), Gaps = 2/109 (1%) Frame = +2 Query: 80 FRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHILNW 259 F EA +G+ H N+ L G P ++V +YM NG+L T L++ Q + Sbjct: 560 FLGEASIMGQFDHPNIIHLEGVVTKSKPV--MIVTEYMENGSLDTFLKKNDGQ------F 611 Query: 260 PMRHLIAL--GVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGL 400 + L+ + G++ G+ +L G +H D+ +NIL +++ +SDFGL Sbjct: 612 TVIQLVGMLRGIAAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGL 660
>ABL2_HUMAN (P42684) Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine| leukemia viral oncogene homolog 2) (Tyrosine kinase ARG) Length = 1182 Score = 52.0 bits (123), Expect = 9e-07 Identities = 37/124 (29%), Positives = 61/124 (49%) Frame = +2 Query: 41 TSADGAVVVEEGSFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLL 220 T + + VEE F KEA + +KH NL L G PP +V +YMP GNL L Sbjct: 318 TLKEDTMEVEE--FLKEAAVMKEIKHPNLVQLLGVCTLEPPFY--IVTEYMPYGNLLDYL 373 Query: 221 QEASHQDGHILNWPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGL 400 +E + ++ + + +A +S + +L + IH D+ +N L + ++DFGL Sbjct: 374 RECNREE---VTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGL 430 Query: 401 EPMV 412 ++ Sbjct: 431 SRLM 434
>EPHA3_CHICK (P29318) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ETK1) (CEK4) Length = 983 Score = 52.0 bits (123), Expect = 9e-07 Identities = 38/136 (27%), Positives = 65/136 (47%), Gaps = 11/136 (8%) Frame = +2 Query: 26 LRLPS---------TSADGAVVVEEGSFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLL 178 L+LPS T G + F EA +G+ H N+ L G P ++ Sbjct: 640 LKLPSKKEISVAIKTLKAGYTEKQRRDFLGEASIMGQFDHPNIIRLEGVVTKSKPV--MI 697 Query: 179 VYDYMPNGNLATLLQEASHQDGHILNWPMRHLIAL--GVSRGLAFLHQSGVIHGDVKPQN 352 V +YM NG+L + L++ H + + L+ + G++ G+ +L G +H D+ +N Sbjct: 698 VTEYMENGSLDSFLRK------HDAQFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARN 751 Query: 353 ILFDADFEPHLSDFGL 400 IL +++ +SDFGL Sbjct: 752 ILINSNLVCKVSDFGL 767
>EPHA5_CHICK (P54755) Ephrin type-A receptor 5 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor CEK7) Length = 1013 Score = 52.0 bits (123), Expect = 9e-07 Identities = 33/109 (30%), Positives = 57/109 (52%), Gaps = 2/109 (1%) Frame = +2 Query: 80 FRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHILNW 259 F EA +G+ H N+ L G P ++V +YM NG+L T L++ Q + Sbjct: 697 FLGEASIMGQFDHPNIIHLEGVVTKSKPV--MIVTEYMENGSLDTFLKKNDGQ------F 748 Query: 260 PMRHLIAL--GVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGL 400 + L+ + G++ G+ +L G +H D+ +NIL +++ +SDFGL Sbjct: 749 TVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGL 797
>SSK2_YEAST (P53599) MAP kinase kinase kinase SSK2 (EC 2.7.11.25) (Suppressor of| sensor kinase 2) Length = 1579 Score = 51.6 bits (122), Expect = 1e-06 Identities = 28/71 (39%), Positives = 41/71 (57%) Frame = +2 Query: 185 DYMPNGNLATLLQEASHQDGHILNWPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFD 364 +Y G+LA LL+ G I + + + L + GLA+LH+SG++H DVKP+NIL D Sbjct: 1345 EYCEGGSLAALLEH-----GRIEDEMVTQVYTLQLLEGLAYLHESGIVHRDVKPENILLD 1399 Query: 365 ADFEPHLSDFG 397 + DFG Sbjct: 1400 FNGVIKYVDFG 1410
>EPHA3_RAT (O08680) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor REK4) (TYRO-4) Length = 984 Score = 51.6 bits (122), Expect = 1e-06 Identities = 32/109 (29%), Positives = 57/109 (52%), Gaps = 2/109 (1%) Frame = +2 Query: 80 FRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHILNW 259 F EA +G+ H N+ L G P ++V +YM NG+L + L++ H + Sbjct: 668 FLGEASIMGQFDHPNIIRLEGVVTKSKPV--MIVTEYMENGSLDSFLRK------HDAQF 719 Query: 260 PMRHLIAL--GVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGL 400 + L+ + G++ G+ +L G +H D+ +NIL +++ +SDFGL Sbjct: 720 TVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGL 768
>PKN1_THETN (Q8R9T6) Probable serine/threonine-protein kinase Sps1 (EC| 2.7.11.1) Length = 625 Score = 51.6 bits (122), Expect = 1e-06 Identities = 39/128 (30%), Positives = 65/128 (50%) Frame = +2 Query: 17 LAILRLPSTSADGAVVVEEGSFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMP 196 + ILR P +AD V + F++E+++ + H N+ + Y G D+ +V +Y+ Sbjct: 38 IKILR-PEFAADENFVKK---FKRESQAAASLSHPNIVGI--YDVGQEGDIYYIVMEYVK 91 Query: 197 NGNLATLLQEASHQDGHILNWPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFE 376 L L++E +G L IA V R L H++ +IH D+KPQNIL + Sbjct: 92 GRTLKELIRE----NGGPLEVKRAVEIASQVCRALDHAHKNKIIHRDIKPQNILVTDEDV 147 Query: 377 PHLSDFGL 400 ++DFG+ Sbjct: 148 VKVTDFGI 155
>FYN_XENLA (P13406) Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2)| (p59-Fyn) Length = 536 Score = 51.6 bits (122), Expect = 1e-06 Identities = 34/112 (30%), Positives = 58/112 (51%) Frame = +2 Query: 77 SFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHILN 256 SF +EA+ + ++KH L L YA + +V +YM G+L L++ +G L Sbjct: 309 SFLEEAQIMKKLKHDKLVQL---YAVVSEEPIYIVTEYMSKGSLLDFLKDG---EGRALK 362 Query: 257 WPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGLEPMV 412 P +A V+RG+A++ + IH D++ NIL ++DFGL ++ Sbjct: 363 LPNLVDMAAQVARGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLI 414
>EPHA3_HUMAN (P29320) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ETK1) (HEK) (HEK4) Length = 983 Score = 51.6 bits (122), Expect = 1e-06 Identities = 32/109 (29%), Positives = 57/109 (52%), Gaps = 2/109 (1%) Frame = +2 Query: 80 FRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHILNW 259 F EA +G+ H N+ L G P ++V +YM NG+L + L++ H + Sbjct: 667 FLGEASIMGQFDHPNIIRLEGVVTKSKPV--MIVTEYMENGSLDSFLRK------HDAQF 718 Query: 260 PMRHLIAL--GVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGL 400 + L+ + G++ G+ +L G +H D+ +NIL +++ +SDFGL Sbjct: 719 TVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGL 767
>KGS9_YEAST (P43637) Probable serine/threonine-protein kinase YGL179C (EC| 2.7.11.1) Length = 560 Score = 51.2 bits (121), Expect = 1e-06 Identities = 33/115 (28%), Positives = 49/115 (42%), Gaps = 3/115 (2%) Frame = +2 Query: 65 VEEGSFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQ---EASH 235 VE +E E + R H N+ L P LV +Y G + + E Sbjct: 96 VENPRVNQEIEVMKRCHHENVVELYEILNDPESTKVYLVLEYCSRGPVKWCPENKMEIKA 155 Query: 236 QDGHILNWPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGL 400 IL + + L V GL +LH G+ H D+KP N+L ++ +SDFG+ Sbjct: 156 VGPSILTFQQSRKVVLDVVSGLEYLHSQGITHRDIKPSNLLISSNGTVKISDFGV 210
>KCC1D_MOUSE (Q8BW96) Calcium/calmodulin-dependent protein kinase type 1D (EC| 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK) (mCKLiK) Length = 385 Score = 51.2 bits (121), Expect = 1e-06 Identities = 36/137 (26%), Positives = 63/137 (45%), Gaps = 3/137 (2%) Frame = +2 Query: 8 GTVLAILRLPSTSADGAVVVEEGSFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYD 187 G + A+ +P + G +E S E L ++KH N+ L Y P + LV Sbjct: 46 GKLFAVKCIPKKALKG----KESSIENEIAVLRKIKHENIVALEDIYESP--NHLYLVMQ 99 Query: 188 YMPNGNLATLLQEASHQDGHILNWPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILF-- 361 + G L + E + +R ++ + +LH+ G++H D+KP+N+L+ Sbjct: 100 LVSGGELFDRIVEKGFYTEKDASTLIRQVLD-----AVYYLHRMGIVHRDLKPENLLYYS 154 Query: 362 -DADFEPHLSDFGLEPM 409 D + + +SDFGL M Sbjct: 155 QDEESKIMISDFGLSKM 171
>KCC1D_HUMAN (Q8IU85) Calcium/calmodulin-dependent protein kinase type 1D (EC| 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK) Length = 385 Score = 51.2 bits (121), Expect = 1e-06 Identities = 36/137 (26%), Positives = 63/137 (45%), Gaps = 3/137 (2%) Frame = +2 Query: 8 GTVLAILRLPSTSADGAVVVEEGSFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYD 187 G + A+ +P + G +E S E L ++KH N+ L Y P + LV Sbjct: 46 GKLFAVKCIPKKALKG----KESSIENEIAVLRKIKHENIVALEDIYESP--NHLYLVMQ 99 Query: 188 YMPNGNLATLLQEASHQDGHILNWPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILF-- 361 + G L + E + +R ++ + +LH+ G++H D+KP+N+L+ Sbjct: 100 LVSGGELFDRIVEKGFYTEKDASTLIRQVLD-----AVYYLHRMGIVHRDLKPENLLYYS 154 Query: 362 -DADFEPHLSDFGLEPM 409 D + + +SDFGL M Sbjct: 155 QDEESKIMISDFGLSKM 171
>EPHA8_HUMAN (P29322) Ephrin type-A receptor 8 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) (HEK3) Length = 1005 Score = 51.2 bits (121), Expect = 1e-06 Identities = 33/109 (30%), Positives = 55/109 (50%), Gaps = 2/109 (1%) Frame = +2 Query: 80 FRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHILNW 259 F EA +G+ H N+ L G + ++V +YM NG+L T L+ Q + Sbjct: 681 FLSEASIMGQFDHPNIIRLEGVVTRGR--LAMIVTEYMENGSLDTFLRTHDGQ------F 732 Query: 260 PMRHLIAL--GVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGL 400 + L+ + GV G+ +L G +H D+ +N+L D++ +SDFGL Sbjct: 733 TIMQLVGMLRGVGAGMRYLSDLGYVHRDLAARNVLVDSNLVCKVSDFGL 781
>GUC2C_CAVPO (P70106) Heat-stable enterotoxin receptor precursor (GC-C)| (Intestinal guanylate cyclase) (EC 4.6.1.2) (STA receptor) (Guanylyl cyclase C) Length = 1076 Score = 51.2 bits (121), Expect = 1e-06 Identities = 31/113 (27%), Positives = 59/113 (52%), Gaps = 4/113 (3%) Frame = +2 Query: 71 EGSF-RKEAESLGRVKHRNLTVLRGYYAGPPPDVRLL-VYDYMPNGNLATLLQEA-SHQD 241 +G+F K+ L ++ + L +Y D R+ V +Y G+L +L E S+ D Sbjct: 525 DGNFSEKQKIELDKLLPSDFYSLTKFYGTVKLDTRIFGVIEYCERGSLREVLNETISYPD 584 Query: 242 GHILNWPMRHLIALGVSRGLAFLHQSGV-IHGDVKPQNILFDADFEPHLSDFG 397 G I+ W + + +++G+++LH S + +HG +K N + D+ ++DFG Sbjct: 585 GTIMGWEFKISVLYDIAKGMSYLHSSKIEVHGRLKSTNCVVDSRMVVKITDFG 637
>RIPK4_HUMAN (P57078) Receptor-interacting serine/threonine-protein kinase 4 (EC| 2.7.11.1) (Ankyrin repeat domain protein 3) (PKC-delta-interacting protein kinase) Length = 832 Score = 51.2 bits (121), Expect = 1e-06 Identities = 44/132 (33%), Positives = 59/132 (44%), Gaps = 2/132 (1%) Frame = +2 Query: 11 TVLAILRLPSTSADGAVVVEEGSFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDY 190 T LAI PS D E +EA+ + K R + + G P LV +Y Sbjct: 46 TWLAIKCSPSLHVDDR---ERMELLEEAKKMEMAKFRYILPVYGICREPVG----LVMEY 98 Query: 191 MPNGNLATLLQEASHQDGHILNWPMRHLIALGVSRGLAFLHQSG--VIHGDVKPQNILFD 364 M G+L LL L W +R I + G+ FLH ++H D+KP NIL D Sbjct: 99 METGSLEKLLASEP------LPWDLRFRIIHETAVGMNFLHCMAPPLLHLDLKPANILLD 152 Query: 365 ADFEPHLSDFGL 400 A + +SDFGL Sbjct: 153 AHYHVKISDFGL 164
>ARK1_SCHPO (O59790) Serine/threonine-protein kinase ark1 (EC 2.7.11.1)| (Aurora-related kinase 1) Length = 355 Score = 50.8 bits (120), Expect = 2e-06 Identities = 33/110 (30%), Positives = 58/110 (52%), Gaps = 1/110 (0%) Frame = +2 Query: 71 EGSFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRL-LVYDYMPNGNLATLLQEASHQDGH 247 E R+E E ++H+N+ L G++ + R+ L+ ++ G L L+ A Sbjct: 131 EKQVRREIEIQSNLRHKNILRLYGHFHD---EKRIYLILEFAGRGELYQHLRRAKRFSEE 187 Query: 248 ILNWPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFG 397 + + +++ + + L++LH+ VIH D+KP+NIL D E LSDFG Sbjct: 188 VAS---KYIFQM--ANALSYLHKKHVIHRDIKPENILLGIDGEIKLSDFG 232
>ABL_FSVHY (P10447) Tyrosine-protein kinase transforming protein Abl (EC| 2.7.10.2) (V-abl) Length = 439 Score = 50.8 bits (120), Expect = 2e-06 Identities = 36/124 (29%), Positives = 61/124 (49%) Frame = +2 Query: 41 TSADGAVVVEEGSFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLL 220 T + + VEE F KEA + +KH NL L G PP ++ ++M GNL L Sbjct: 221 TLKEDTMEVEE--FLKEAAVMKEIKHPNLVQLLGVCTREPPFY--IITEFMTYGNLLDYL 276 Query: 221 QEASHQDGHILNWPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGL 400 +E + Q+ +N + +A +S + +L + IH D+ +N L + ++DFGL Sbjct: 277 RECNRQE---VNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGL 333 Query: 401 EPMV 412 ++ Sbjct: 334 SRLM 337
>PCTK1_HUMAN (Q00536) Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22)| (PCTAIRE-motif protein kinase 1) Length = 496 Score = 50.8 bits (120), Expect = 2e-06 Identities = 40/142 (28%), Positives = 62/142 (43%), Gaps = 10/142 (7%) Frame = +2 Query: 5 EGTVLAILRLPSTSADGAVVVEEGSFR----------KEAESLGRVKHRNLTVLRGYYAG 154 EGT + + S D V ++E +E L +KH N+ L Sbjct: 173 EGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHT 232 Query: 155 PPPDVRLLVYDYMPNGNLATLLQEASHQDGHILNWPMRHLIALGVSRGLAFLHQSGVIHG 334 LV++Y+ L++ G+I+N L + RGLA+ H+ V+H Sbjct: 233 EKS--LTLVFEYLDKD-----LKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQKVLHR 285 Query: 335 DVKPQNILFDADFEPHLSDFGL 400 D+KPQN+L + E L+DFGL Sbjct: 286 DLKPQNLLINERGELKLADFGL 307
>MRCKG_MOUSE (Q80UW5) Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1)| (CDC42-binding protein kinase gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (Myotonic dystrophy protein kinase-like alpha) (MRCK gamma) (DMPK-like gamma Length = 1551 Score = 50.8 bits (120), Expect = 2e-06 Identities = 37/110 (33%), Positives = 51/110 (46%) Frame = +2 Query: 68 EEGSFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGH 247 E FR+E + L + R +T L +YA + LV DY G+L TLL + Sbjct: 112 ETACFREERDVLVKGDSRWVTAL--HYAFQDEEYLYLVMDYYAGGDLLTLLSRFEDR--- 166 Query: 248 ILNWPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFG 397 L + + + LHQ G +H DVKP NIL D + L+DFG Sbjct: 167 -LPPELAQFYLAEMVLAIHSLHQLGYVHRDVKPDNILLDMNGHIRLADFG 215
>MRCKG_HUMAN (Q6DT37) Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1)| (CDC42-binding protein kinase gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (Myotonic dystrophy protein kinase-like alpha) (MRCK gamma) (DMPK-like gamma Length = 1551 Score = 50.8 bits (120), Expect = 2e-06 Identities = 36/110 (32%), Positives = 51/110 (46%) Frame = +2 Query: 68 EEGSFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGH 247 E FR+E + L + R +T L +YA + LV DY G+L TLL + Sbjct: 112 ETACFREERDVLVKGDSRWVTTL--HYAFQDEEYLYLVMDYYAGGDLLTLLSRFEDR--- 166 Query: 248 ILNWPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFG 397 L + + + LHQ G +H DVKP N+L D + L+DFG Sbjct: 167 -LPPELAQFYLAEMVLAIHSLHQLGYVHRDVKPDNVLLDVNGHIRLADFG 215
>PKN2_CLOAB (Q97IC2) Probable serine/threonine protein kinase CAC1728 (EC| 2.7.11.1) Length = 657 Score = 50.8 bits (120), Expect = 2e-06 Identities = 29/108 (26%), Positives = 58/108 (53%), Gaps = 1/108 (0%) Frame = +2 Query: 80 FRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQD-GHILN 256 F++EA + R+ + N+ + Y G +V +V +Y+ L L++E + I++ Sbjct: 55 FKREASAAARIANANIVNI--YDVGADGNVNYIVMEYVAGKTLKKLIKENGKIEFNKIID 112 Query: 257 WPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGL 400 + A +++ L F H++G++H D+KP NI+ D ++DFG+ Sbjct: 113 Y------ATQIAKALNFAHKNGIVHRDIKPHNIMVTDDDIIKVTDFGI 154
>ABL1_HUMAN (P00519) Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2)| (p150) (c-ABL) (Abelson murine leukemia viral oncogene homolog 1) Length = 1130 Score = 50.8 bits (120), Expect = 2e-06 Identities = 36/124 (29%), Positives = 61/124 (49%) Frame = +2 Query: 41 TSADGAVVVEEGSFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLL 220 T + + VEE F KEA + +KH NL L G PP ++ ++M GNL L Sbjct: 272 TLKEDTMEVEE--FLKEAAVMKEIKHPNLVQLLGVCTREPPFY--IITEFMTYGNLLDYL 327 Query: 221 QEASHQDGHILNWPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGL 400 +E + Q+ +N + +A +S + +L + IH D+ +N L + ++DFGL Sbjct: 328 RECNRQE---VNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGL 384 Query: 401 EPMV 412 ++ Sbjct: 385 SRLM 388
>STK6_MOUSE (P97477) Serine/threonine-protein kinase 6 (EC 2.7.11.1)| (Aurora-family kinase 1) (Aurora/IPL1-related kinase 1) (Ipl1- and aurora-related kinase 1) (Aurora-A) (Serine/threonine-protein kinase Ayk1) Length = 395 Score = 50.4 bits (119), Expect = 3e-06 Identities = 38/128 (29%), Positives = 61/128 (47%) Frame = +2 Query: 14 VLAILRLPSTSADGAVVVEEGSFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYM 193 +LA+ L T + A V E R+E E ++H N+ L GY+ L+ +Y Sbjct: 149 ILALKVLFKTQLEKANV--EHQLRREVEIQSHLRHPNILRLYGYFHDATRVY--LILEYA 204 Query: 194 PNGNLATLLQEASHQDGHILNWPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADF 373 P G + LQ+ S D + L + L++ H VIH D+KP+N+L ++ Sbjct: 205 PLGTVYRELQKLSKFDEQRTATYITEL-----ANALSYCHSKRVIHRDIKPENLLLGSNG 259 Query: 374 EPHLSDFG 397 E ++DFG Sbjct: 260 ELKIADFG 267
>PCTK1_RAT (Q63686) Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22)| (PCTAIRE-motif protein kinase 1) Length = 496 Score = 50.4 bits (119), Expect = 3e-06 Identities = 39/142 (27%), Positives = 62/142 (43%), Gaps = 10/142 (7%) Frame = +2 Query: 5 EGTVLAILRLPSTSADGAVVVEEGSFR----------KEAESLGRVKHRNLTVLRGYYAG 154 EGT + + S D V ++E +E L +KH N+ L Sbjct: 173 EGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHT 232 Query: 155 PPPDVRLLVYDYMPNGNLATLLQEASHQDGHILNWPMRHLIALGVSRGLAFLHQSGVIHG 334 LV++Y+ L++ G+++N L + RGLA+ H+ V+H Sbjct: 233 EKS--LTLVFEYLDKD-----LKQYLDDCGNVINMHNVKLFLFQLLRGLAYCHRQKVLHR 285 Query: 335 DVKPQNILFDADFEPHLSDFGL 400 D+KPQN+L + E L+DFGL Sbjct: 286 DLKPQNLLINERGELKLADFGL 307
>PCTK1_MOUSE (Q04735) Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22)| (PCTAIRE-motif protein kinase 1) (CRK5) Length = 496 Score = 50.4 bits (119), Expect = 3e-06 Identities = 39/142 (27%), Positives = 62/142 (43%), Gaps = 10/142 (7%) Frame = +2 Query: 5 EGTVLAILRLPSTSADGAVVVEEGSFR----------KEAESLGRVKHRNLTVLRGYYAG 154 EGT + + S D V ++E +E L +KH N+ L Sbjct: 173 EGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHT 232 Query: 155 PPPDVRLLVYDYMPNGNLATLLQEASHQDGHILNWPMRHLIALGVSRGLAFLHQSGVIHG 334 LV++Y+ L++ G+++N L + RGLA+ H+ V+H Sbjct: 233 EKS--LTLVFEYLDKD-----LKQYLDDCGNVINMHNVKLFLFQLLRGLAYCHRQKVLHR 285 Query: 335 DVKPQNILFDADFEPHLSDFGL 400 D+KPQN+L + E L+DFGL Sbjct: 286 DLKPQNLLINERGELKLADFGL 307
>IPL1_YEAST (P38991) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) (Increase-in-ploidy protein 1) Length = 367 Score = 50.4 bits (119), Expect = 3e-06 Identities = 34/111 (30%), Positives = 57/111 (51%), Gaps = 5/111 (4%) Frame = +2 Query: 80 FRKEAESLGRVKHRNLTVLRGYYAGPPPDVRL-LVYDYMPNGNLATLLQEASHQDGHILN 256 FR+E E + H NLT GY+ + R+ L+ +Y+ NG + LL+ L+ Sbjct: 149 FRREVEIQTSLNHPNLTKSYGYFHD---EKRVYLLMEYLVNGEMYKLLR---------LH 196 Query: 257 WPMRHLIALG----VSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFG 397 P ++A ++ L ++H+ +IH D+KP+NIL + L+DFG Sbjct: 197 GPFNDILASDYIYQIANALDYMHKKNIIHRDIKPENILIGFNNVIKLTDFG 247
>MK14B_DROME (O61443) Mitogen-activated protein kinase 14B (EC 2.7.11.24) (MAP| kinase p38b) (D-p38b) Length = 365 Score = 50.4 bits (119), Expect = 3e-06 Identities = 30/111 (27%), Positives = 55/111 (49%), Gaps = 6/111 (5%) Frame = +2 Query: 86 KEAESLGRVKHRNLT-VLRGYYAGPPPDV-----RLLVYDYMPNGNLATLLQEASHQDGH 247 +E L + H N+ +L ++ G P D ++ + ++ + +L +++ D H Sbjct: 70 RELRLLKHMDHENVIGLLDVFHPGQPADSLDQFQQVYMVTHLMDADLNNIIRTQKLSDDH 129 Query: 248 ILNWPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGL 400 + + + RGL ++H +GVIH D+KP NI + D E + DFGL Sbjct: 130 V------QFLVYQILRGLKYIHSAGVIHRDLKPSNIAVNEDCELRILDFGL 174
>LATS1_MOUSE (Q8BYR2) Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large| tumor suppressor homolog 1) (WARTS protein kinase) Length = 1129 Score = 50.4 bits (119), Expect = 3e-06 Identities = 32/93 (34%), Positives = 46/93 (49%) Frame = +2 Query: 122 NLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHILNWPMRHLIALGVSRGL 301 N V+R YY+ D V DY+P G++ +LL ++ + + L S Sbjct: 761 NEWVVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRMGIFPENLARFYIAELTCAVES--- 817 Query: 302 AFLHQSGVIHGDVKPQNILFDADFEPHLSDFGL 400 +H+ G IH D+KP NIL D D L+DFGL Sbjct: 818 --VHKMGFIHRDIKPDNILIDRDGHIKLTDFGL 848
>GUC2D_RAT (P51839) Olfactory guanylyl cyclase GC-D precursor (EC 4.6.1.2)| (Guanylate cyclase, olfactory) Length = 1110 Score = 50.4 bits (119), Expect = 3e-06 Identities = 28/96 (29%), Positives = 49/96 (51%) Frame = +2 Query: 110 VKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHILNWPMRHLIALGV 289 ++H N+T G + GP +V +V ++ G+L LL+ + L+W + + L + Sbjct: 607 MRHENVTAFLGLFVGP--EVSAMVLEHCARGSLEDLLRNEDLR----LDWTFKASLLLDL 660 Query: 290 SRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFG 397 RGL +LH HG +K +N + D F ++D G Sbjct: 661 IRGLRYLHHRHFPHGRLKSRNCVVDTRFVLKITDHG 696
>TESK1_RAT (Q63572) Dual specificity testis-specific protein kinase 1 (EC| 2.7.12.1) (Testicular protein kinase 1) Length = 628 Score = 50.4 bits (119), Expect = 3e-06 Identities = 34/108 (31%), Positives = 51/108 (47%), Gaps = 3/108 (2%) Frame = +2 Query: 86 KEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHILNWPM 265 +E + + R++H N+ G L +YM G L LL L+WP+ Sbjct: 94 REVQLMNRLRHPNILRFMGVCVHQGQLHALT--EYMNGGTLEQLLSSPEP-----LSWPV 146 Query: 266 RHLIALGVSRGLAFLHQSGVIHGDVKPQNILF---DADFEPHLSDFGL 400 R +AL +++GL +LH GV H D+ +N L D F + DFGL Sbjct: 147 RLHLALDIAQGLRYLHAKGVFHRDLTSKNCLVRREDGGFTAVVGDFGL 194
>LIMK1_DROME (Q8IR79) LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (dLIMK)| Length = 1257 Score = 50.1 bits (118), Expect = 3e-06 Identities = 33/109 (30%), Positives = 53/109 (48%), Gaps = 1/109 (0%) Frame = +2 Query: 77 SFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRL-LVYDYMPNGNLATLLQEASHQDGHIL 253 +F KE L + HR++ G D +L +V +Y+ G L+E H +L Sbjct: 442 NFIKEVAVLRLLDHRHVLKFIGVLY---KDKKLHMVTEYVAGG----CLKELIHDPAQVL 494 Query: 254 NWPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGL 400 WP R +A ++ G+++LH +IH D+ N L D ++DFGL Sbjct: 495 PWPQRVRLARDIACGMSYLHSMNIIHRDLNSMNCLVREDRSVIVADFGL 543
>M3K1_MOUSE (P53349) Mitogen-activated protein kinase kinase kinase 1 (EC| 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1) Length = 1493 Score = 50.1 bits (118), Expect = 3e-06 Identities = 39/135 (28%), Positives = 75/135 (55%), Gaps = 5/135 (3%) Frame = +2 Query: 8 GTVLAILRLP---STSADGAVVVEEGSFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLL 178 GT++A+ ++ +TS++ VVE + R+E +G + H N+ + G A L Sbjct: 1247 GTLMAVKQVTYVRNTSSEQEEVVE--ALREEIRMMGHLNHPNIIRMLG--ATCEKSNYNL 1302 Query: 179 VYDYMPNGNLATLLQE-ASHQDGHILNWPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNI 355 ++M G++A LL + + ++ ++N+ + L RGL++LH++ +IH DVK N+ Sbjct: 1303 FIEWMAGGSVAHLLSKYGAFKESVVINYTEQLL------RGLSYLHENQIIHRDVKGANL 1356 Query: 356 LFDADFEP-HLSDFG 397 L D+ + ++DFG Sbjct: 1357 LIDSTGQRLRIADFG 1371
>ANKK1_HUMAN (Q8NFD2) Ankyrin repeat and protein kinase domain-containing| protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (X-kinase) (SgK288) Length = 765 Score = 50.1 bits (118), Expect = 3e-06 Identities = 33/107 (30%), Positives = 55/107 (51%), Gaps = 2/107 (1%) Frame = +2 Query: 86 KEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHILNWPM 265 +EA + ++K +++ + G P +V ++M NG+L +L H L W + Sbjct: 70 EEAAKMKKIKFQHIVSIYGVCKQPLG----IVMEFMANGSLEKVLST------HSLCWKL 119 Query: 266 RHLIALGVSRGLAFLH--QSGVIHGDVKPQNILFDADFEPHLSDFGL 400 R I S + FLH + ++H D+KP NIL D++ +SDFGL Sbjct: 120 RFRIIHETSLAMNFLHSIKPPLLHLDLKPGNILLDSNMHVKISDFGL 166
>EPHA2_MOUSE (Q03145) Ephrin type-A receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2) Length = 977 Score = 50.1 bits (118), Expect = 3e-06 Identities = 32/109 (29%), Positives = 57/109 (52%), Gaps = 2/109 (1%) Frame = +2 Query: 80 FRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHILNW 259 F EA +G+ H N+ L G + P +++ +YM NG L L+E +DG + Sbjct: 661 FLSEASIMGQFSHHNIIPLEGVVSKYKP--MMIITEYMENGALDKFLRE---KDGE---F 712 Query: 260 PMRHLIAL--GVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGL 400 + L+ + G++ G+ +L +H D+ +NIL +++ +SDFGL Sbjct: 713 SVLQLVGMLRGIASGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGL 761
>CRK1_LEIME (Q06309) Cell division protein kinase 2 homolog CRK1 (EC 2.7.11.23)| Length = 301 Score = 50.1 bits (118), Expect = 3e-06 Identities = 44/144 (30%), Positives = 66/144 (45%), Gaps = 12/144 (8%) Frame = +2 Query: 5 EGTVLAILRLPSTSADGAVVV--------EEG---SFRKEAESLGRVKHRNLTVLRGYYA 151 EGT + + TS V + EEG + +E L ++H N+ L Sbjct: 13 EGTYGVVYKARDTSTAATVALKRIRLDSEEEGVPCTAIREISLLKELRHENIVKLLDVCH 72 Query: 152 GPPPDVRL-LVYDYMPNGNLATLLQEASHQDGHILNWPMRHLIALGVSRGLAFLHQSGVI 328 + RL +V++Y+ L +E + D + MR L+ RG+AF HQ V+ Sbjct: 73 S---EHRLTIVFEYLDLDLKKYLDRENGNLDAATIQHFMRDLL-----RGVAFCHQRSVL 124 Query: 329 HGDVKPQNILFDADFEPHLSDFGL 400 H D+KPQN+L + E L DFGL Sbjct: 125 HRDLKPQNLLISREKELKLGDFGL 148
>TESK1_MOUSE (O70146) Dual specificity testis-specific protein kinase 1 (EC| 2.7.12.1) (Testicular protein kinase 1) Length = 627 Score = 50.1 bits (118), Expect = 3e-06 Identities = 34/108 (31%), Positives = 51/108 (47%), Gaps = 3/108 (2%) Frame = +2 Query: 86 KEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHILNWPM 265 +E + + R++H N+ G L +YM G L LL L+WP+ Sbjct: 94 REVQLMNRLRHPNILRFMGVCVHQGQLHALT--EYMNGGTLEQLLSSPEP-----LSWPV 146 Query: 266 RHLIALGVSRGLAFLHQSGVIHGDVKPQNILF---DADFEPHLSDFGL 400 R +AL +++GL +LH GV H D+ +N L D F + DFGL Sbjct: 147 RLHLALDIAQGLRYLHAKGVFHRDLTSKNCLVRREDRGFTAVVGDFGL 194
>CTR1_ARATH (Q05609) Serine/threonine-protein kinase CTR1 (EC 2.7.11.1)| Length = 821 Score = 50.1 bits (118), Expect = 3e-06 Identities = 31/109 (28%), Positives = 57/109 (52%), Gaps = 2/109 (1%) Frame = +2 Query: 80 FRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHILNW 259 F +E + R++H N+ + G PP +V +Y+ G+L LL ++ ++ L+ Sbjct: 593 FLREVAIMKRLRHPNIVLFMGAVTQPPN--LSIVTEYLSRGSLYRLLHKSGAREQ--LDE 648 Query: 260 PMRHLIALGVSRGLAFLHQSG--VIHGDVKPQNILFDADFEPHLSDFGL 400 R +A V++G+ +LH ++H D+K N+L D + + DFGL Sbjct: 649 RRRLSMAYDVAKGMNYLHNRNPPIVHRDLKSPNLLVDKKYTVKVCDFGL 697
>LATS1_HUMAN (O95835) Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large| tumor suppressor homolog 1) (WARTS protein kinase) (h-warts) Length = 1130 Score = 50.1 bits (118), Expect = 3e-06 Identities = 31/93 (33%), Positives = 45/93 (48%) Frame = +2 Query: 122 NLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHILNWPMRHLIALGVSRGL 301 N V+R YY+ D V DY+P G++ +LL I + ++ + Sbjct: 762 NEWVVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRMG-----IFPESLARFYIAELTCAV 816 Query: 302 AFLHQSGVIHGDVKPQNILFDADFEPHLSDFGL 400 +H+ G IH D+KP NIL D D L+DFGL Sbjct: 817 ESVHKMGFIHRDIKPDNILIDRDGHIKLTDFGL 849
>EPHA3_BRARE (O13146) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ZEK1) (EPH-like kinase 1) Length = 981 Score = 49.7 bits (117), Expect = 4e-06 Identities = 32/107 (29%), Positives = 55/107 (51%) Frame = +2 Query: 80 FRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHILNW 259 F EA +G+ H N+ L G P ++V +YM NG+L T L++ DG Sbjct: 672 FLSEASIMGQFDHPNIIRLEGVVTRCKPV--MIVTEYMENGSLDTFLKK---HDGQFTVI 726 Query: 260 PMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGL 400 + ++ G++ G+ +L + +H D+ +NIL + + +SDFGL Sbjct: 727 QLLGMLR-GIAAGMQYLSEMNYVHRDLAARNILVNRNLVCKVSDFGL 772
>TNIK_HUMAN (Q9UKE5) TRAF2 and NCK-interacting kinase (EC 2.7.11.1)| Length = 1360 Score = 49.7 bits (117), Expect = 4e-06 Identities = 39/133 (29%), Positives = 61/133 (45%), Gaps = 5/133 (3%) Frame = +2 Query: 17 LAILRLPSTSADGAVVVEEGSFRKEAESLGRVKH-RNLTVLRGYYAGPPP----DVRLLV 181 LA +++ + D EE ++E L + H RN+ G + P D LV Sbjct: 50 LAAIKVMDVTGD-----EEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLV 104 Query: 182 YDYMPNGNLATLLQEASHQDGHILNWPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILF 361 ++ G++ L++ G+ L I + RGL+ LHQ VIH D+K QN+L Sbjct: 105 MEFCGAGSVTDLIKNTK---GNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLL 161 Query: 362 DADFEPHLSDFGL 400 + E L DFG+ Sbjct: 162 TENAEVKLVDFGV 174
>AURKB_MOUSE (O70126) Serine/threonine-protein kinase 12 (EC 2.7.11.1)| (Aurora-related kinase 2) (Serine/threonine-protein kinase 5) (STK-1) (Aurora-B) Length = 345 Score = 49.7 bits (117), Expect = 4e-06 Identities = 34/109 (31%), Positives = 49/109 (44%) Frame = +2 Query: 71 EGSFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHI 250 E R+E E +KH N+ L Y+ L+ +Y P G L LQ++ D Sbjct: 124 EHQLRREIEIQAHLKHPNILQLYNYFYDQQRIY--LILEYAPRGELYKELQKSRTFDEQR 181 Query: 251 LNWPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFG 397 M L S L + H+ VIH D+KP+N+L E ++DFG Sbjct: 182 TATIMEEL-----SDALTYCHKKKVIHRDIKPENLLLGLQGELKIADFG 225
>YRK_CHICK (Q02977) Proto-oncogene tyrosine-protein kinase Yrk (EC 2.7.10.2)| (p60-Yrk) (Yes-related kinase) Length = 535 Score = 49.7 bits (117), Expect = 4e-06 Identities = 31/112 (27%), Positives = 58/112 (51%) Frame = +2 Query: 77 SFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHILN 256 +F +EA+ + R++H L L YA + +V ++M G+L L++ DG L Sbjct: 308 AFLEEAQIMKRLRHDKLVQL---YAVVSEEPIYIVTEFMSQGSLLDFLKDG---DGRYLK 361 Query: 257 WPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGLEPMV 412 P +A ++ G+A++ + IH D++ NIL + ++DFGL ++ Sbjct: 362 LPQLVDMAAQIAAGMAYIERMNYIHRDLRAANILVGDNLVCKIADFGLARLI 413
>AURKB_RAT (O55099) Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-| and Ipl1-like midbody-associated protein 1) (AIM-1) (Aurora-B) Length = 343 Score = 49.7 bits (117), Expect = 4e-06 Identities = 34/109 (31%), Positives = 49/109 (44%) Frame = +2 Query: 71 EGSFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHI 250 E R+E E +KH N+ L Y+ L+ +Y P G L LQ++ D Sbjct: 122 EHQLRREIEIQAHLKHPNILQLYNYFYDQQRIY--LILEYAPRGELYKELQKSGTFDEQR 179 Query: 251 LNWPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFG 397 M L S L + H+ VIH D+KP+N+L E ++DFG Sbjct: 180 TATIMEEL-----SDALMYCHKKKVIHRDIKPENLLLGLQGELKIADFG 223
>ANPRA_RAT (P18910) Atrial natriuretic peptide receptor A precursor (ANP-A)| (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor) Length = 1057 Score = 49.7 bits (117), Expect = 4e-06 Identities = 31/106 (29%), Positives = 56/106 (52%), Gaps = 1/106 (0%) Frame = +2 Query: 89 EAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHILNWPMR 268 E + + V++ +LT G PP ++ +L +Y P G+L +L+ S L+W R Sbjct: 579 ELKHMRDVQNEHLTRFVGACTDPP-NICILT-EYCPRGSLQDILENESIT----LDWMFR 632 Query: 269 HLIALGVSRGLAFLHQSGVI-HGDVKPQNILFDADFEPHLSDFGLE 403 + + + +G+ FLH + HG++K N + D F ++D+GLE Sbjct: 633 YSLTNDIVKGMLFLHNGAICSHGNLKSSNCVVDGRFVLKITDYGLE 678
>HOG1_CANAL (Q92207) Mitogen-activated protein kinase HOG1 (EC 2.7.11.24) (MAP| kinase HOG1) Length = 377 Score = 49.7 bits (117), Expect = 4e-06 Identities = 31/105 (29%), Positives = 52/105 (49%) Frame = +2 Query: 86 KEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHILNWPM 265 +E + L +KH NL L + P D+ + + + +L LL + I + Sbjct: 69 RELKLLKHLKHENLITLDDIFISPLEDIYFV--NELQGTDLHRLLNSRPLEKQFIQYFTY 126 Query: 266 RHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGL 400 + + RGL ++H +GVIH D+KP NIL + + + + DFGL Sbjct: 127 Q------IMRGLKYIHSAGVIHRDLKPSNILINENCDLKICDFGL 165
>TNIK_MOUSE (P83510) Traf2 and NCK-interacting kinase (EC 2.7.11.1) (Fragments)| Length = 916 Score = 49.7 bits (117), Expect = 4e-06 Identities = 39/133 (29%), Positives = 61/133 (45%), Gaps = 5/133 (3%) Frame = +2 Query: 17 LAILRLPSTSADGAVVVEEGSFRKEAESLGRVKH-RNLTVLRGYYAGPPP----DVRLLV 181 LA +++ + D EE ++E L + H RN+ G + P D LV Sbjct: 50 LAAIKVMDVTGD-----EEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLV 104 Query: 182 YDYMPNGNLATLLQEASHQDGHILNWPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILF 361 ++ G++ L++ G+ L I + RGL+ LHQ VIH D+K QN+L Sbjct: 105 MEFCGAGSVTDLIKNTK---GNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLL 161 Query: 362 DADFEPHLSDFGL 400 + E L DFG+ Sbjct: 162 TENAEVKLVDFGV 174
>RIPK3_MOUSE (Q9QZL0) Receptor-interacting serine/threonine-protein kinase 3 (EC| 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) (mRIP3) Length = 486 Score = 49.7 bits (117), Expect = 4e-06 Identities = 35/118 (29%), Positives = 57/118 (48%), Gaps = 5/118 (4%) Frame = +2 Query: 62 VVEEGSFRKEAESLGRVKHRNLTVLRGYYAGPPPDV---RLLVYDYMPNGNLATLLQEAS 232 +V E +++ +++ N+ +L G D + LV +M NG+LA LLQ Sbjct: 52 IVNSKKISWEVKAMVNLRNENVLLLLGVTEDLQWDFVSGQALVTRFMENGSLAGLLQPEC 111 Query: 233 HQDGHILNWPMRHLIALGVSRGLAFLHQSG--VIHGDVKPQNILFDADFEPHLSDFGL 400 + WP+ + V G+ +LH ++H D+KP NIL D + L+DFGL Sbjct: 112 PRP-----WPLLCRLLQEVVLGMCYLHSLDPPLLHRDLKPSNILLDPELHAKLADFGL 164
>ANPRA_HUMAN (P16066) Atrial natriuretic peptide receptor A precursor (ANP-A)| (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor) Length = 1061 Score = 49.7 bits (117), Expect = 4e-06 Identities = 31/106 (29%), Positives = 56/106 (52%), Gaps = 1/106 (0%) Frame = +2 Query: 89 EAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHILNWPMR 268 E + + V++ +LT G PP ++ +L +Y P G+L +L+ S L+W R Sbjct: 583 ELKHMRDVQNEHLTRFVGACTDPP-NICILT-EYCPRGSLQDILENESIT----LDWMFR 636 Query: 269 HLIALGVSRGLAFLHQSGVI-HGDVKPQNILFDADFEPHLSDFGLE 403 + + + +G+ FLH + HG++K N + D F ++D+GLE Sbjct: 637 YSLTNDIVKGMLFLHNGAICSHGNLKSSNCVVDGRFVLKITDYGLE 682
>ORB6_SCHPO (O13310) Serine/threonine-protein kinase orb6 (EC 2.7.11.1)| Length = 469 Score = 49.7 bits (117), Expect = 4e-06 Identities = 29/86 (33%), Positives = 42/86 (48%) Frame = +2 Query: 143 YYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHILNWPMRHLIALGVSRGLAFLHQSG 322 YYA L+ +++P G+L T+L + + M + +A +H+ G Sbjct: 157 YYAFQDSLYLYLIMEFLPGGDLMTMLINYDTFSEDVTRFYMAECVL-----AIADVHRMG 211 Query: 323 VIHGDVKPQNILFDADFEPHLSDFGL 400 IH D+KP NIL D D LSDFGL Sbjct: 212 YIHRDIKPDNILIDRDGHIKLSDFGL 237
>CDC7_SCHPO (P41892) Cell division control protein 7 (EC 2.7.11.1)| Length = 1062 Score = 49.3 bits (116), Expect = 6e-06 Identities = 32/106 (30%), Positives = 51/106 (48%) Frame = +2 Query: 83 RKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHILNWP 262 + E + L + H N+ RG Y D ++ +Y NG+L ++ + +++ Sbjct: 54 KMEIDLLKNLDHPNIVKYRGSYQ--TNDSLCIILEYCENGSLRSICKNFGKIPENLVA-- 109 Query: 263 MRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGL 400 L V +GL +LH GVIH D+K NIL D L+DFG+ Sbjct: 110 ---LYTFQVLQGLLYLHNQGVIHRDIKGANILTTKDGTIKLADFGV 152
>KPCE_RAT (P09216) Protein kinase C epsilon type (EC 2.7.11.13)| (nPKC-epsilon) Length = 737 Score = 49.3 bits (116), Expect = 6e-06 Identities = 35/96 (36%), Positives = 46/96 (47%) Frame = +2 Query: 113 KHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHILNWPMRHLIALGVS 292 KH LT L Y D V +Y+ G+L +Q + D P A V+ Sbjct: 465 KHPYLTQL--YCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDE-----PRSGFYAAEVT 517 Query: 293 RGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGL 400 L FLHQ GVI+ D+K NIL DA+ L+DFG+ Sbjct: 518 SALMFLHQHGVIYRDLKLDNILLDAEGHSKLADFGM 553
>KPCE_MOUSE (P16054) Protein kinase C epsilon type (EC 2.7.11.13)| (nPKC-epsilon) Length = 737 Score = 49.3 bits (116), Expect = 6e-06 Identities = 35/96 (36%), Positives = 46/96 (47%) Frame = +2 Query: 113 KHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHILNWPMRHLIALGVS 292 KH LT L Y D V +Y+ G+L +Q + D P A V+ Sbjct: 465 KHPYLTQL--YCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDE-----PRSRFYAAEVT 517 Query: 293 RGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGL 400 L FLHQ GVI+ D+K NIL DA+ L+DFG+ Sbjct: 518 SALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGM 553
>KPCE_HUMAN (Q02156) Protein kinase C epsilon type (EC 2.7.11.13)| (nPKC-epsilon) Length = 737 Score = 49.3 bits (116), Expect = 6e-06 Identities = 35/96 (36%), Positives = 46/96 (47%) Frame = +2 Query: 113 KHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHILNWPMRHLIALGVS 292 KH LT L Y D V +Y+ G+L +Q + D P A V+ Sbjct: 465 KHPYLTQL--YCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDE-----PRSRFYAAEVT 517 Query: 293 RGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGL 400 L FLHQ GVI+ D+K NIL DA+ L+DFG+ Sbjct: 518 SALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGM 553
>KOK0_YEAST (Q12236) Probable serine/threonine-protein kinase YOL100W (EC| 2.7.11.1) Length = 1081 Score = 49.3 bits (116), Expect = 6e-06 Identities = 23/71 (32%), Positives = 40/71 (56%) Frame = +2 Query: 185 DYMPNGNLATLLQEASHQDGHILNWPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFD 364 +Y PNG+ +L+++ D + +I + +LH +G+IH D+KP+NIL D Sbjct: 258 EYAPNGDFLSLMKKYGSLDETCARYYAAQIID-----AIDYLHSNGIIHRDIKPENILLD 312 Query: 365 ADFEPHLSDFG 397 + + L+DFG Sbjct: 313 GEMKIKLTDFG 323
>ANPRA_MOUSE (P18293) Atrial natriuretic peptide receptor A precursor (ANP-A)| (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor) Length = 1057 Score = 49.3 bits (116), Expect = 6e-06 Identities = 31/106 (29%), Positives = 56/106 (52%), Gaps = 1/106 (0%) Frame = +2 Query: 89 EAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHILNWPMR 268 E + + V++ +LT G PP ++ +L +Y P G+L +L+ S L+W R Sbjct: 579 ELKHMRDVQNEHLTRFVGACTDPP-NICILT-EYCPRGSLQDILENESIT----LDWMFR 632 Query: 269 HLIALGVSRGLAFLHQSGV-IHGDVKPQNILFDADFEPHLSDFGLE 403 + + + +G+ FLH + HG++K N + D F ++D+GLE Sbjct: 633 YSLTNDIVKGMLFLHNGAIGSHGNLKSSNCVVDGRFVLKITDYGLE 678
>FYN_MOUSE (P39688) Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2)| (p59-Fyn) Length = 533 Score = 49.3 bits (116), Expect = 6e-06 Identities = 33/112 (29%), Positives = 57/112 (50%) Frame = +2 Query: 77 SFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHILN 256 SF +EA+ + ++KH L L YA + +V +YM G+L L++ +G L Sbjct: 306 SFLEEAQIMKKLKHDKLVQL---YAVVSEEPIYIVTEYMSKGSLLDFLKDG---EGRALK 359 Query: 257 WPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGLEPMV 412 P +A V+ G+A++ + IH D++ NIL ++DFGL ++ Sbjct: 360 LPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLI 411
>RIPK5_XENLA (Q67E01) Receptor-interacting serine/threonine-protein kinase 5 (EC| 2.7.11.1) (Dusty protein kinase) (Dusty PK) Length = 916 Score = 49.3 bits (116), Expect = 6e-06 Identities = 36/109 (33%), Positives = 50/109 (45%), Gaps = 14/109 (12%) Frame = +2 Query: 113 KHRNLTVLRGYYAGPPPDVRLLV--------YDYMPNGNLATLL-QEASHQDGHI----- 250 KH N L +Y P LV Y Y ++A LL E H+D ++ Sbjct: 678 KHWNDLALEFHYMRSLPKHERLVDLHGSVIDYSYGGGSSIAVLLITERLHRDLYVGLKTG 737 Query: 251 LNWPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFG 397 L+ R IAL V G+ FLH GV+H D+K +N+L D ++D G Sbjct: 738 LSLETRLQIALDVVEGIRFLHNQGVVHRDIKLKNVLLDKKHRAKITDLG 786
>KPCE_RABIT (P10830) Protein kinase C epsilon type (EC 2.7.11.13)| (nPKC-epsilon) Length = 736 Score = 49.3 bits (116), Expect = 6e-06 Identities = 35/96 (36%), Positives = 46/96 (47%) Frame = +2 Query: 113 KHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHILNWPMRHLIALGVS 292 KH LT L Y D V +Y+ G+L +Q + D P A V+ Sbjct: 464 KHPYLTQL--YCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDE-----PRSRFYAAEVT 516 Query: 293 RGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGL 400 L FLHQ GVI+ D+K NIL DA+ L+DFG+ Sbjct: 517 SALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGM 552
>YES_CANFA (Q28923) Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2)| (p61-Yes) (c-Yes) Length = 538 Score = 49.3 bits (116), Expect = 6e-06 Identities = 31/112 (27%), Positives = 58/112 (51%) Frame = +2 Query: 77 SFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHILN 256 +F +EA+ + +++H L L YA + +V ++M G+L L+E DG L Sbjct: 311 AFLQEAQIMKKLRHDKLVPL---YAVVSEEPIYIVTEFMSKGSLLDFLKEG---DGKYLK 364 Query: 257 WPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGLEPMV 412 P +A ++ G+A++ + IH D++ NIL + ++DFGL ++ Sbjct: 365 LPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLVCKIADFGLARLI 416
>FYN_XIPHE (P27446) Proto-oncogene tyrosine-protein kinase FYN (EC 2.7.10.2)| (P59-FYN) Length = 536 Score = 49.3 bits (116), Expect = 6e-06 Identities = 32/112 (28%), Positives = 58/112 (51%) Frame = +2 Query: 77 SFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHILN 256 SF +EA+ + +++H L L YA + +V +YM G+L L++ +G L Sbjct: 309 SFLEEAQIMKKLRHDKLVQL---YAVVSEEPIYIVTEYMSKGSLLDFLKDG---EGRALK 362 Query: 257 WPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGLEPMV 412 P +A V+ G+A++ + IH D++ NIL + ++DFGL ++ Sbjct: 363 LPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGDNLVCKIADFGLARLI 414
>YES_HUMAN (P07947) Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2)| (p61-Yes) (c-Yes) Length = 542 Score = 49.3 bits (116), Expect = 6e-06 Identities = 31/112 (27%), Positives = 58/112 (51%) Frame = +2 Query: 77 SFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHILN 256 +F +EA+ + +++H L L YA + +V ++M G+L L+E DG L Sbjct: 315 AFLQEAQIMKKLRHDKLVPL---YAVVSEEPIYIVTEFMSKGSLLDFLKEG---DGKYLK 368 Query: 257 WPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGLEPMV 412 P +A ++ G+A++ + IH D++ NIL + ++DFGL ++ Sbjct: 369 LPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLVCKIADFGLARLI 420
>STK_HYDAT (P17713) Tyrosine-protein kinase STK (EC 2.7.10.2) (P57-STK)| Length = 509 Score = 48.9 bits (115), Expect = 7e-06 Identities = 34/112 (30%), Positives = 57/112 (50%) Frame = +2 Query: 77 SFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHILN 256 SF EA + +++H++L L + P +V +YM G+L L + +G L Sbjct: 279 SFLDEAGVMKKLRHKHLVQLYAICSDREPIY--IVTEYMSGGSLLDYLSKG---EGVNLQ 333 Query: 257 WPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGLEPMV 412 P +A V+ G+AFL G IH D+ +NIL ++ ++DFGL ++ Sbjct: 334 LPTLIDMAAQVASGMAFLEAQGYIHRDLAARNILVGENYICKVADFGLARLI 385
>FYN_HUMAN (P06241) Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2)| (p59-Fyn) (Protooncogene Syn) (SLK) Length = 536 Score = 48.9 bits (115), Expect = 7e-06 Identities = 33/112 (29%), Positives = 57/112 (50%) Frame = +2 Query: 77 SFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHILN 256 SF +EA+ + ++KH L L YA + +V +YM G+L L++ +G L Sbjct: 309 SFLEEAQIMKKLKHDKLVQL---YAVVSEEPIYIVTEYMNKGSLLDFLKDG---EGRALK 362 Query: 257 WPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGLEPMV 412 P +A V+ G+A++ + IH D++ NIL ++DFGL ++ Sbjct: 363 LPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLI 414
>HOG1_ZYGRO (O93982) Mitogen-activated protein kinase HOG1 (EC 2.7.11.24) (MAP| kinase HOG1) Length = 380 Score = 48.9 bits (115), Expect = 7e-06 Identities = 30/105 (28%), Positives = 51/105 (48%) Frame = +2 Query: 86 KEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHILNWPM 265 +E + L ++H NL L+ + P D+ + + +L LLQ + + Sbjct: 69 RELKLLKHLRHENLICLQDIFLSPLEDIYFVTE--LQGTDLHRLLQTRPLEKQFV----- 121 Query: 266 RHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGL 400 + RGL ++H +GVIH D+KP NIL + + + + DFGL Sbjct: 122 -QYFLYQILRGLKYVHSAGVIHRDLKPSNILINENCDLKICDFGL 165
>IPL1_YARLI (Q6C3J2) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) Length = 371 Score = 48.9 bits (115), Expect = 7e-06 Identities = 33/109 (30%), Positives = 55/109 (50%) Frame = +2 Query: 71 EGSFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHI 250 E FR+E E ++H N+ L G++ D L+ +Y+ +G L LL+ +Q Sbjct: 141 EKQFRREVEIQSNLRHTNVLRLFGHFHDK--DRVYLILEYVVHGELYKLLR---NQKRFT 195 Query: 251 LNWPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFG 397 + ++ + S L +LH +IH D+KP+NIL + +SDFG Sbjct: 196 ESTASSYIYQM--SEALLYLHGKNIIHRDIKPENILLHFNDTIKISDFG 242
>ABL1_MOUSE (P00520) Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2)| (p150) (c-ABL) (Abelson murine leukemia viral oncogene homolog 1) Length = 1123 Score = 48.9 bits (115), Expect = 7e-06 Identities = 35/124 (28%), Positives = 61/124 (49%) Frame = +2 Query: 41 TSADGAVVVEEGSFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLL 220 T + + VEE F KEA + +KH NL L G PP ++ ++M GNL L Sbjct: 272 TLKEDTMEVEE--FLKEAAVMKEIKHPNLVQLLGVCTREPPFY--IITEFMTYGNLLDYL 327 Query: 221 QEASHQDGHILNWPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGL 400 +E + Q+ ++ + +A +S + +L + IH D+ +N L + ++DFGL Sbjct: 328 RECNRQE---VSAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGL 384 Query: 401 EPMV 412 ++ Sbjct: 385 SRLM 388
>STK6_RAT (P59241) Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Aurora-A)| (ratAurA) Length = 397 Score = 48.9 bits (115), Expect = 7e-06 Identities = 32/109 (29%), Positives = 52/109 (47%) Frame = +2 Query: 71 EGSFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHI 250 E R+E E ++H N+ L GY+ L+ +Y P G + LQ+ S D Sbjct: 168 EHQLRREVEIQSHLRHPNILRLYGYFHDATRVY--LILEYAPLGTVYRELQKLSKFDEQR 225 Query: 251 LNWPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFG 397 + L + L++ H VIH D+KP+N+L ++ E ++DFG Sbjct: 226 TATYITEL-----ANALSYCHSKRVIHRDIKPENLLLGSNGELKIADFG 269
>M3K10_HUMAN (Q02779) Mitogen-activated protein kinase kinase kinase 10 (EC| 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST) Length = 954 Score = 48.9 bits (115), Expect = 7e-06 Identities = 41/128 (32%), Positives = 59/128 (46%), Gaps = 11/128 (8%) Frame = +2 Query: 50 DGAVVVEEGSFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEA 229 D AV E+ +EA G ++H N+ LRG PP LV +Y G L+ +L Sbjct: 134 DPAVTAEQVC--QEARLFGALQHPNIIALRGACLNPPH--LCLVMEYARGGALSRVLAGR 189 Query: 230 SHQDGHILNWPMRHLIALGVSRGLAFLHQSG---VIHGDVKPQNILFDADFEPH------ 382 ++NW A+ V+RG+ +LH +IH D+K NIL E H Sbjct: 190 RVPPHVLVNW------AVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTV 243 Query: 383 --LSDFGL 400 ++DFGL Sbjct: 244 LKITDFGL 251
>HOG1_YEAST (P32485) Mitogen-activated protein kinase HOG1 (EC 2.7.11.24) (MAP| kinase HOG1) (Osmosensing protein HOG1) Length = 435 Score = 48.9 bits (115), Expect = 7e-06 Identities = 30/105 (28%), Positives = 51/105 (48%) Frame = +2 Query: 86 KEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHILNWPM 265 +E + L ++H NL L+ + P D+ + + +L LLQ + + Sbjct: 69 RELKLLKHLRHENLICLQDIFLSPLEDIYFVTE--LQGTDLHRLLQTRPLEKQFV----- 121 Query: 266 RHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGL 400 + RGL ++H +GVIH D+KP NIL + + + + DFGL Sbjct: 122 -QYFLYQILRGLKYVHSAGVIHRDLKPSNILINENCDLKICDFGL 165
>ABL_MLVAB (P00521) Tyrosine-protein kinase transforming protein Abl (EC| 2.7.10.2) (V-abl) Length = 746 Score = 48.9 bits (115), Expect = 7e-06 Identities = 35/124 (28%), Positives = 61/124 (49%) Frame = +2 Query: 41 TSADGAVVVEEGSFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLL 220 T + + VEE F KEA + +KH NL L G PP ++ ++M GNL L Sbjct: 158 TLKEDTMEVEE--FLKEAAVMKEIKHPNLVQLLGVCTREPPFY--IITEFMTYGNLLDYL 213 Query: 221 QEASHQDGHILNWPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGL 400 +E + Q+ ++ + +A +S + +L + IH D+ +N L + ++DFGL Sbjct: 214 RECNRQE---VSAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGL 270 Query: 401 EPMV 412 ++ Sbjct: 271 SRLM 274
>YES_MOUSE (Q04736) Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2)| (p61-Yes) (c-Yes) Length = 540 Score = 48.9 bits (115), Expect = 7e-06 Identities = 31/112 (27%), Positives = 58/112 (51%) Frame = +2 Query: 77 SFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHILN 256 +F +EA+ + +++H L L YA + +V ++M G+L L+E DG L Sbjct: 313 AFLQEAQIMKKLRHDKLVPL---YAVVSEEPIYIVTEFMSKGSLLDFLKEG---DGKYLK 366 Query: 257 WPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGLEPMV 412 P +A ++ G+A++ + IH D++ NIL + ++DFGL ++ Sbjct: 367 LPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLI 418
>PCTK2_HUMAN (Q00537) Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22)| (PCTAIRE-motif protein kinase 2) Length = 523 Score = 48.5 bits (114), Expect = 1e-05 Identities = 34/106 (32%), Positives = 53/106 (50%), Gaps = 1/106 (0%) Frame = +2 Query: 86 KEAESLGRVKHRNLTVLRGYYAGPPPDVRL-LVYDYMPNGNLATLLQEASHQDGHILNWP 262 +E L +KH N+ L D L LV++Y+ L++ G+I++ Sbjct: 237 REVSLLKDLKHANIVTLHDIVH---TDKSLTLVFEYLDKD-----LKQYMDDCGNIMSMH 288 Query: 263 MRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGL 400 L + RGLA+ H+ V+H D+KPQN+L + E L+DFGL Sbjct: 289 NVKLFLYQILRGLAYCHRRKVLHRDLKPQNLLINEKGELKLADFGL 334
>HOG1_CANGA (Q6FIU2) Mitogen-activated protein kinase HOG1 (EC 2.7.11.24) (MAP| kinase HOG1) Length = 447 Score = 48.5 bits (114), Expect = 1e-05 Identities = 30/105 (28%), Positives = 53/105 (50%) Frame = +2 Query: 86 KEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHILNWPM 265 +E + L ++H NL L+ + P D+ + + +L LLQ + + + Sbjct: 69 RELKLLKHLRHENLICLQDIFLSPLEDIYFVTE--LQGTDLHRLLQTRPLEKQFVQYFHY 126 Query: 266 RHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGL 400 + L RGL ++H +GV+H D+KP NIL + + + + DFGL Sbjct: 127 QIL------RGLKYVHSAGVVHRDLKPSNILINENCDLKICDFGL 165
>HOG1_ASHGO (Q750A9) Mitogen-activated protein kinase HOG1 (EC 2.7.11.24) (MAP| kinase HOG1) Length = 447 Score = 48.5 bits (114), Expect = 1e-05 Identities = 31/105 (29%), Positives = 49/105 (46%) Frame = +2 Query: 86 KEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHILNWPM 265 +E + L ++H NL L + P D+ + + +L LLQ L Sbjct: 69 RELKLLKHLRHENLICLEDIFLSPLEDIYFVTE--LQGTDLHRLLQTRP------LEKQF 120 Query: 266 RHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGL 400 + RGL ++H +GVIH D+KP NIL + + + + DFGL Sbjct: 121 LQYFLYQILRGLKYVHSAGVIHRDLKPSNILINENCDLKICDFGL 165
>GUC2C_RAT (P23897) Heat-stable enterotoxin receptor precursor (GC-C)| (Intestinal guanylate cyclase) (EC 4.6.1.2) (STA receptor) Length = 1072 Score = 48.5 bits (114), Expect = 1e-05 Identities = 29/113 (25%), Positives = 59/113 (52%), Gaps = 4/113 (3%) Frame = +2 Query: 71 EGSF-RKEAESLGRVKHRNLTVLRGYYAGPPPDVRLL-VYDYMPNGNLATLLQEA-SHQD 241 +G+F K+ L ++ + L +Y D R+ V +Y G+L +L + S+ D Sbjct: 521 DGNFSEKQKIELNKLLQSDYYNLTKFYGTVKLDTRIFGVVEYCERGSLREVLNDTISYPD 580 Query: 242 GHILNWPMRHLIALGVSRGLAFLHQSGV-IHGDVKPQNILFDADFEPHLSDFG 397 G ++W + + +++G+++LH S + +HG +K N + D+ ++DFG Sbjct: 581 GTFMDWEFKISVLNDIAKGMSYLHSSKIEVHGRLKSTNCVVDSRMVVKITDFG 633
>EPHA8_RAT (P29321) Ephrin type-A receptor 8 (EC 2.7.10.1) (Tyrosine-protein| kinase receptor EEK) (EPH- and ELK-related kinase) (Fragment) Length = 372 Score = 48.5 bits (114), Expect = 1e-05 Identities = 34/109 (31%), Positives = 53/109 (48%), Gaps = 2/109 (1%) Frame = +2 Query: 80 FRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHILNW 259 F +EA +G+ H N+ L G + ++V +YM NG+L L+ Q + Sbjct: 48 FLREAAIMGQFDHPNIIRLEGVVTRGR--LAMIVTEYMENGSLDAFLRTHDGQ------F 99 Query: 260 PMRHLIAL--GVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGL 400 + L+ + GV G+ +L G IH D+ +NIL D +SDFGL Sbjct: 100 TILQLVGMLKGVGAGMRYLSDLGYIHRDLAARNILVDGRLVCKVSDFGL 148
>AAPK1_RAT (P54645) 5'-AMP-activated protein kinase catalytic subunit alpha-1| (EC 2.7.11.1) (AMPK alpha-1 chain) Length = 548 Score = 48.5 bits (114), Expect = 1e-05 Identities = 32/113 (28%), Positives = 56/113 (49%) Frame = +2 Query: 74 GSFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHIL 253 G R+E ++L +H ++ L Y P +V +Y+ G L + + +G + Sbjct: 59 GKIRREIQNLKLFRHPHIIKL--YQVISTPSDIFMVMEYVSGGELFDYICK----NGRLD 112 Query: 254 NWPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGLEPMV 412 R L +S G+ + H+ V+H D+KP+N+L DA ++DFGL M+ Sbjct: 113 EKESRRLFQQILS-GVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMM 164
>AAPK1_MOUSE (Q5EG47) 5'-AMP-activated protein kinase catalytic subunit alpha-1| (EC 2.7.11.1) (AMPK alpha-1 chain) Length = 548 Score = 48.5 bits (114), Expect = 1e-05 Identities = 32/113 (28%), Positives = 56/113 (49%) Frame = +2 Query: 74 GSFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHIL 253 G R+E ++L +H ++ L Y P +V +Y+ G L + + +G + Sbjct: 59 GKIRREIQNLKLFRHPHIIKL--YQVISTPSDIFMVMEYVSGGELFDYICK----NGRLD 112 Query: 254 NWPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGLEPMV 412 R L +S G+ + H+ V+H D+KP+N+L DA ++DFGL M+ Sbjct: 113 EKESRRLFQQILS-GVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMM 164
>MKK1_YEAST (P32490) MAP kinase kinase MKK1/SSP32 (EC 2.7.12.2)| Length = 508 Score = 48.5 bits (114), Expect = 1e-05 Identities = 27/75 (36%), Positives = 42/75 (56%) Frame = +2 Query: 176 LVYDYMPNGNLATLLQEASHQDGHILNWPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNI 355 + +YM +L + + + G I + IA V RGL++LH+ VIH D+KPQNI Sbjct: 297 IAMEYMGGRSLDAIYKNLLERGGRISEKVLGK-IAEAVLRGLSYLHEKKVIHRDIKPQNI 355 Query: 356 LFDADFEPHLSDFGL 400 L + + + L DFG+ Sbjct: 356 LLNENGQVKLCDFGV 370
>SKH1_SCHPO (Q9Y884) MAP kinase kinase skh1/pek1 (EC 2.7.12.2)| Length = 363 Score = 48.5 bits (114), Expect = 1e-05 Identities = 27/80 (33%), Positives = 41/80 (51%) Frame = +2 Query: 176 LVYDYMPNGNLATLLQEASHQDGHILNWPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNI 355 + +Y G+L + + Q G P+ IA GV GL++LH +IH D+KP NI Sbjct: 154 IAMEYCGAGSLDAIYKRVRSQGGRTGERPLGK-IAFGVLSGLSYLHDRKIIHRDIKPSNI 212 Query: 356 LFDADFEPHLSDFGLEPMVV 415 L + + L DFG+ +V Sbjct: 213 LLTSKGQVKLCDFGVSGELV 232
>GUC2G_RAT (P55205) Guanylate cyclase 2G precursor (EC 4.6.1.2) (Guanylyl| cyclase receptor G) (GC-G) (Kinase-like domain-containing soluble guanylyl cyclase) (ksGC) Length = 1100 Score = 48.5 bits (114), Expect = 1e-05 Identities = 30/113 (26%), Positives = 55/113 (48%), Gaps = 1/113 (0%) Frame = +2 Query: 65 VEEGSFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDG 244 +++ + +E + +KH N+ G PP +V Y G+L +L+ + H+ Sbjct: 595 IKKPTVLREVWLMCELKHENIVPFFGVCTEPPNIC--IVTQYCKKGSLKDVLRNSDHE-- 650 Query: 245 HILNWPMRHLIALGVSRGLAFLHQSGV-IHGDVKPQNILFDADFEPHLSDFGL 400 ++W + + G+ FLH S + HG++KP N L D+ + L+ FGL Sbjct: 651 --MDWIFKLSFVYDIVNGMLFLHGSPLRSHGNLKPSNCLVDSHMQLKLAGFGL 701
>EPHA7_CHICK (O42422) Ephrin type-A receptor 7 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor CEPHA7) (Tyrosine-protein kinase receptor CEK11) Length = 993 Score = 48.5 bits (114), Expect = 1e-05 Identities = 32/113 (28%), Positives = 57/113 (50%), Gaps = 2/113 (1%) Frame = +2 Query: 80 FRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHILNW 259 F EA +G+ H N+ L G P ++V +YM NG L L++ Q + Sbjct: 674 FLCEASIMGQFDHPNVVHLEGVVTRGKPV--MIVIEYMENGALDAFLRKHDGQ------F 725 Query: 260 PMRHLIAL--GVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGLEPMV 412 + L+ + G++ G+ +L G +H D+ +NIL +++ +SDFGL ++ Sbjct: 726 TVIQLVGMLRGIAAGMRYLADMGYVHRDLAARNILVNSNLVCKVSDFGLSRVI 778
>AAPK1_PONPY (Q5RDH5) 5'-AMP-activated protein kinase catalytic subunit alpha-1| (EC 2.7.11.1) (AMPK alpha-1 chain) Length = 550 Score = 48.5 bits (114), Expect = 1e-05 Identities = 32/113 (28%), Positives = 56/113 (49%) Frame = +2 Query: 74 GSFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHIL 253 G R+E ++L +H ++ L Y P +V +Y+ G L + + +G + Sbjct: 61 GKIRREIQNLKLFRHPHIIKL--YQVISTPSDIFMVMEYVSGGELFDYICK----NGRLD 114 Query: 254 NWPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGLEPMV 412 R L +S G+ + H+ V+H D+KP+N+L DA ++DFGL M+ Sbjct: 115 EKESRRLFQQILS-GVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMM 166
>AAPK1_HUMAN (Q13131) 5'-AMP-activated protein kinase catalytic subunit alpha-1| (EC 2.7.11.1) (AMPK alpha-1 chain) Length = 550 Score = 48.5 bits (114), Expect = 1e-05 Identities = 32/113 (28%), Positives = 56/113 (49%) Frame = +2 Query: 74 GSFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHIL 253 G R+E ++L +H ++ L Y P +V +Y+ G L + + +G + Sbjct: 61 GKIRREIQNLKLFRHPHIIKL--YQVISTPSDIFMVMEYVSGGELFDYICK----NGRLD 114 Query: 254 NWPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGLEPMV 412 R L +S G+ + H+ V+H D+KP+N+L DA ++DFGL M+ Sbjct: 115 EKESRRLFQQILS-GVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMM 166
>ANPRB_BOVIN (P46197) Atrial natriuretic peptide receptor B precursor (ANP-B)| (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor) Length = 1047 Score = 48.5 bits (114), Expect = 1e-05 Identities = 27/82 (32%), Positives = 47/82 (57%), Gaps = 1/82 (1%) Frame = +2 Query: 158 PPDVRLLVYDYMPNGNLATLLQEASHQDGHILNWPMRHLIALGVSRGLAFLHQSGVI-HG 334 PP++ +V +Y P G+L +L+ D L+W R+ + + +G+AFLH S + HG Sbjct: 589 PPNI-CIVTEYCPRGSLQDILEN----DSINLDWMFRYSLINDLVKGMAFLHNSIIASHG 643 Query: 335 DVKPQNILFDADFEPHLSDFGL 400 +K N + D+ F ++D+GL Sbjct: 644 SLKSSNCVVDSRFVLKITDYGL 665
>EPHB5_CHICK (Q07497) Ephrin type-B receptor 5 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase CEK9) Length = 1002 Score = 48.5 bits (114), Expect = 1e-05 Identities = 32/122 (26%), Positives = 60/122 (49%), Gaps = 2/122 (1%) Frame = +2 Query: 41 TSADGAVVVEEGSFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLL 220 T G + F EA +G+ +H N+ L G P ++V ++M NG+L + L Sbjct: 670 TLKSGYTDEQRREFLSEASIMGQFEHPNVIHLEGVVTKSRPV--MIVTEFMENGSLDSFL 727 Query: 221 QEASHQDGHILNWPMRHLIAL--GVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDF 394 ++ Q + + L+ + G++ G+ +L +H D+ +NIL +++ +SDF Sbjct: 728 RQKEGQ------FSVLQLVGMLRGIAAGMRYLSDMNYVHRDLAARNILVNSNLVCKVSDF 781 Query: 395 GL 400 GL Sbjct: 782 GL 783
>PK1_NPVLD (P41720) Serine/threonine-protein kinase 1 (EC 2.7.11.1)| Length = 274 Score = 48.1 bits (113), Expect = 1e-05 Identities = 32/93 (34%), Positives = 48/93 (51%) Frame = +2 Query: 122 NLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHILNWPMRHLIALGVSRGL 301 N LR +Y+ LLV DY+P+G+L L+Q L P LIA + L Sbjct: 67 NKYFLRLFYSLHSLREHLLVMDYIPDGDLFDLMQTEPR-----LREPEISLIAYQLIDAL 121 Query: 302 AFLHQSGVIHGDVKPQNILFDADFEPHLSDFGL 400 LH+ V+H DVK +N+L+ + ++ D+GL Sbjct: 122 QALHKHNVVHNDVKLENVLYRRFEQIYVCDYGL 154
>ANPRB_RAT (P16067) Atrial natriuretic peptide receptor B precursor (ANP-B)| (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor) Length = 1047 Score = 48.1 bits (113), Expect = 1e-05 Identities = 27/82 (32%), Positives = 47/82 (57%), Gaps = 1/82 (1%) Frame = +2 Query: 158 PPDVRLLVYDYMPNGNLATLLQEASHQDGHILNWPMRHLIALGVSRGLAFLHQSGV-IHG 334 PP++ +V +Y P G+L +L+ D L+W R+ + + +G+AFLH S + HG Sbjct: 589 PPNI-CIVTEYCPRGSLQDILEN----DSINLDWMFRYSLINDLVKGMAFLHNSIISSHG 643 Query: 335 DVKPQNILFDADFEPHLSDFGL 400 +K N + D+ F ++D+GL Sbjct: 644 SLKSSNCVVDSRFVLKITDYGL 665
>ANPRB_MOUSE (Q6VVW5) Atrial natriuretic peptide receptor B precursor (ANP-B)| (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor) Length = 1047 Score = 48.1 bits (113), Expect = 1e-05 Identities = 27/82 (32%), Positives = 47/82 (57%), Gaps = 1/82 (1%) Frame = +2 Query: 158 PPDVRLLVYDYMPNGNLATLLQEASHQDGHILNWPMRHLIALGVSRGLAFLHQSGV-IHG 334 PP++ +V +Y P G+L +L+ D L+W R+ + + +G+AFLH S + HG Sbjct: 589 PPNI-CIVTEYCPRGSLQDILEN----DSINLDWMFRYSLINDLVKGMAFLHNSIISSHG 643 Query: 335 DVKPQNILFDADFEPHLSDFGL 400 +K N + D+ F ++D+GL Sbjct: 644 SLKSSNCVVDSRFVLKITDYGL 665
>ANPRB_HUMAN (P20594) Atrial natriuretic peptide receptor B precursor (ANP-B)| (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor) Length = 1047 Score = 48.1 bits (113), Expect = 1e-05 Identities = 27/82 (32%), Positives = 47/82 (57%), Gaps = 1/82 (1%) Frame = +2 Query: 158 PPDVRLLVYDYMPNGNLATLLQEASHQDGHILNWPMRHLIALGVSRGLAFLHQSGV-IHG 334 PP++ +V +Y P G+L +L+ D L+W R+ + + +G+AFLH S + HG Sbjct: 589 PPNI-CIVTEYCPRGSLQDILEN----DSINLDWMFRYSLINDLVKGMAFLHNSIISSHG 643 Query: 335 DVKPQNILFDADFEPHLSDFGL 400 +K N + D+ F ++D+GL Sbjct: 644 SLKSSNCVVDSRFVLKITDYGL 665
>YPC2_CAEEL (Q11179) Putative serine/threonine-protein kinase C05D10.2 in| chromosome III (EC 2.7.11.24) Length = 470 Score = 48.1 bits (113), Expect = 1e-05 Identities = 30/96 (31%), Positives = 47/96 (48%) Frame = +2 Query: 113 KHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHILNWPMRHLIALGVS 292 KH N+ L + L +++M +L ++++ G IL + I + Sbjct: 69 KHPNVIKLYNIFRADNDRDIYLAFEFM-EADLHNVIKK-----GSILKDVHKQYIMCQLF 122 Query: 293 RGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGL 400 R + FLH V+H D+KP N+L DAD L+DFGL Sbjct: 123 RAIRFLHSGNVLHRDLKPSNVLLDADCRVKLADFGL 158
>AL2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.11.22)| (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein) Length = 384 Score = 48.1 bits (113), Expect = 1e-05 Identities = 35/105 (33%), Positives = 51/105 (48%) Frame = +2 Query: 86 KEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHILNWPM 265 +EA L +KH N+ +L + V++YM L Q S G + + Sbjct: 97 REASLLKGLKHANIVLLHDIIH--TKETLTFVFEYMHTD----LAQYMSQHPGGLHPHNV 150 Query: 266 RHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGL 400 R L + RGLA++H V+H D+KPQN+L E L+DFGL Sbjct: 151 R-LFMFQLLRGLAYIHHQHVLHRDLKPQNLLISHLGELKLADFGL 194
>MINK1_HUMAN (Q8N4C8) Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated| protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK) Length = 1332 Score = 48.1 bits (113), Expect = 1e-05 Identities = 36/116 (31%), Positives = 53/116 (45%), Gaps = 5/116 (4%) Frame = +2 Query: 68 EEGSFRKEAESLGRVKH-RNLTVLRGYYAGPPP----DVRLLVYDYMPNGNLATLLQEAS 232 EE ++E L + H RN+ G + P D LV ++ G++ L++ Sbjct: 62 EEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTK 121 Query: 233 HQDGHILNWPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGL 400 G+ L I + RGLA LH VIH D+K QN+L + E L DFG+ Sbjct: 122 ---GNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGV 174
>KYK2_DICDI (P18161) Tyrosine-protein kinase 2 (EC 2.7.10.2) (Fragment)| Length = 410 Score = 48.1 bits (113), Expect = 1e-05 Identities = 30/108 (27%), Positives = 54/108 (50%), Gaps = 1/108 (0%) Frame = +2 Query: 80 FRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHI-LN 256 F +E ++L + H+N+ + G P ++ +YM G+L +L + + + Sbjct: 150 FIREVQNLKKGNHQNIVMFIGACYKPA----CIITEYMAGGSLYNILHNPNSSTPKVKYS 205 Query: 257 WPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGL 400 +P+ +A ++ GL LH ++H D+ QNIL D +SDFGL Sbjct: 206 FPLVLKMATDMALGLLHLHSITIVHRDLTSQNILLDELGNIKISDFGL 253
>EPHA2_HUMAN (P29317) Ephrin type-A receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) Length = 976 Score = 48.1 bits (113), Expect = 1e-05 Identities = 32/109 (29%), Positives = 57/109 (52%), Gaps = 2/109 (1%) Frame = +2 Query: 80 FRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHILNW 259 F EA +G+ H N+ L G + P +++ +YM NG L L+E +DG + Sbjct: 660 FLGEAGIMGQFSHHNIIRLEGVISKYKP--MMIITEYMENGALDKFLRE---KDGE---F 711 Query: 260 PMRHLIAL--GVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGL 400 + L+ + G++ G+ +L +H D+ +NIL +++ +SDFGL Sbjct: 712 SVLQLVGMLRGIAAGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGL 760
>YES_XIPHE (P27447) Tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes)| Length = 543 Score = 48.1 bits (113), Expect = 1e-05 Identities = 32/112 (28%), Positives = 58/112 (51%) Frame = +2 Query: 77 SFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHILN 256 +F +EA+ + +++H L L YA + +V ++M G+L L+E DG L Sbjct: 316 AFLEEAQIMKKLRHDKLVPL---YAVVSEEPIYIVTEFMGKGSLLDFLKEG---DGKHLK 369 Query: 257 WPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGLEPMV 412 P +A ++ G+AF+ + IH D++ NIL + ++DFGL ++ Sbjct: 370 LPQLVDMASQIADGMAFIERMNYIHRDLRAANILVADNLVCKIADFGLARLI 421
>MLTK_HUMAN (Q9NYL2) Mitogen-activated protein kinase kinase kinase MLT (EC| 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper-and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase Length = 800 Score = 48.1 bits (113), Expect = 1e-05 Identities = 40/137 (29%), Positives = 63/137 (45%), Gaps = 7/137 (5%) Frame = +2 Query: 8 GTVLAILRLPSTSADGAVVVEEG-SFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVY 184 G+ ++ R S D V V++ KEAE L + HRN+ G PP +V Sbjct: 25 GSFGSVYRAKWISQDKEVAVKKLLKIEKEAEILSVLSHRNIIQFYGVILEPPNYG--IVT 82 Query: 185 DYMPNGNLATLLQEASHQD---GHILNWPMRHLIALGVSRGLAFLHQSG---VIHGDVKP 346 +Y G+L + ++ HI+ W A V++G+ +LH VIH D+K Sbjct: 83 EYASLGSLYDYINSNRSEEMDMDHIMTW------ATDVAKGMHYLHMEAPVKVIHRDLKS 136 Query: 347 QNILFDADFEPHLSDFG 397 +N++ AD + DFG Sbjct: 137 RNVVIAADGVLKICDFG 153
>PCTK2_MOUSE (Q8K0D0) Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22)| (PCTAIRE-motif protein kinase 2) Length = 523 Score = 48.1 bits (113), Expect = 1e-05 Identities = 34/106 (32%), Positives = 53/106 (50%), Gaps = 1/106 (0%) Frame = +2 Query: 86 KEAESLGRVKHRNLTVLRGYYAGPPPDVRL-LVYDYMPNGNLATLLQEASHQDGHILNWP 262 +E L +KH N+ L D L LV++Y+ L++ G+I++ Sbjct: 237 REVSLLKDLKHANIVTLHDIVH---TDKSLTLVFEYLDKD-----LKQYMDDCGNIMSMH 288 Query: 263 MRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGL 400 L + RGLA+ H+ V+H D+KPQN+L + E L+DFGL Sbjct: 289 NVKLFLYQILRGLAYCHRRKVLHRDLKPQNLLINERGELKLADFGL 334
>RIPK5_XENTR (Q67E00) Receptor-interacting serine/threonine-protein kinase 5 (EC| 2.7.11.1) (Dusty protein kinase) (Dusty PK) Length = 918 Score = 48.1 bits (113), Expect = 1e-05 Identities = 35/109 (32%), Positives = 50/109 (45%), Gaps = 14/109 (12%) Frame = +2 Query: 113 KHRNLTVLRGYYAGPPPDVRLLV--------YDYMPNGNLATLL-QEASHQDGHI----- 250 KH N L +Y P LV Y Y ++A LL E H+D ++ Sbjct: 680 KHWNDLALEFHYMRSLPKHERLVDLHGSVIDYSYGGGSSIAVLLITERLHRDLYVGLKTG 739 Query: 251 LNWPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFG 397 L+ R IAL V G+ FLH G++H D+K +N+L D ++D G Sbjct: 740 LSLETRLQIALDVVEGIRFLHNQGLVHRDIKLKNVLLDKKHRAKITDLG 788
>MINK1_MOUSE (Q9JM52) Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated| protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK) Length = 1308 Score = 48.1 bits (113), Expect = 1e-05 Identities = 36/116 (31%), Positives = 53/116 (45%), Gaps = 5/116 (4%) Frame = +2 Query: 68 EEGSFRKEAESLGRVKH-RNLTVLRGYYAGPPP----DVRLLVYDYMPNGNLATLLQEAS 232 EE ++E L + H RN+ G + P D LV ++ G++ L++ Sbjct: 62 EEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTK 121 Query: 233 HQDGHILNWPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGL 400 G+ L I + RGLA LH VIH D+K QN+L + E L DFG+ Sbjct: 122 ---GNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGV 174
>YES_CHICK (P09324) Tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes)| Length = 540 Score = 47.8 bits (112), Expect = 2e-05 Identities = 30/112 (26%), Positives = 58/112 (51%) Frame = +2 Query: 77 SFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHILN 256 +F +EA+ + +++H L L YA + +V ++M G+L L+E +G L Sbjct: 313 AFLQEAQIMKKLRHDKLVPL---YAVVSEEPIYIVTEFMTKGSLLDFLKEG---EGKFLK 366 Query: 257 WPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGLEPMV 412 P +A ++ G+A++ + IH D++ NIL + ++DFGL ++ Sbjct: 367 LPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGDNLVCKIADFGLARLI 418
>PSK1_SCHPO (Q12706) Serine/threonine-protein kinase psk1 (EC 2.7.11.22)| Length = 436 Score = 47.8 bits (112), Expect = 2e-05 Identities = 33/106 (31%), Positives = 51/106 (48%) Frame = +2 Query: 83 RKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHILNWP 262 + E + L V+H + R YYA D L+ Y P G L + L E ++ + Sbjct: 138 KNERQILEEVRHP--FICRLYYAFQDHDRLYLILQYAPGGELFSHLAEQRMLPEDVVAFY 195 Query: 263 MRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGL 400 L + L LH+ G+++ D+KP+N L DA+ L+DFGL Sbjct: 196 TAEL-----TLALIHLHKLGIVYRDLKPENCLLDAEGHILLTDFGL 236
>PHKG2_MOUSE (Q9DB30) Phosphorylase b kinase gamma catalytic chain, testis/liver| isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase gamma subunit 2) Length = 406 Score = 47.8 bits (112), Expect = 2e-05 Identities = 39/126 (30%), Positives = 57/126 (45%), Gaps = 14/126 (11%) Frame = +2 Query: 62 VVEEGSFRKEAESLGRVK---HRNLTVLRGYYAGPPPDVRL-----------LVYDYMPN 199 ++E + R E L V+ R + +LR AG P + L LV+D M Sbjct: 54 IMEVSAERLSLEQLEEVRDATRREMHILR-QVAGHPHIITLIDSYESSSFMFLVFDLMRK 112 Query: 200 GNLATLLQEASHQDGHILNWPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEP 379 G L L E MR L+ ++FLH + ++H D+KP+NIL D + + Sbjct: 113 GELFDYLTEKVALSEKETRSIMRSLL-----EAVSFLHANNIVHRDLKPENILLDDNMQI 167 Query: 380 HLSDFG 397 LSDFG Sbjct: 168 RLSDFG 173
>STK11_XENLA (Q91604) Serine/threonine-protein kinase 11 (EC 2.7.11.1)| (Serine/threonine-protein kinase XEEK1) (Egg and embryo kinase 1) Length = 432 Score = 47.8 bits (112), Expect = 2e-05 Identities = 33/110 (30%), Positives = 50/110 (45%) Frame = +2 Query: 71 EGSFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHI 250 E + +KE + L R++HRN+ L +V +Y G L S QD H Sbjct: 95 EANVKKEIQLLRRLRHRNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEML---DSVQDKHF 151 Query: 251 LNWPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGL 400 + H + GL +LH G++H D+KP N+L D +SD G+ Sbjct: 152 PVF-QAHGYFCQLIDGLEYLHSQGIVHKDIKPGNLLLTTDGTLKISDLGV 200
>LRRK2_MOUSE (Q5S006) Leucine-rich repeat serine/threonine-protein kinase 2 (EC| 2.7.11.1) Length = 2527 Score = 47.8 bits (112), Expect = 2e-05 Identities = 38/111 (34%), Positives = 58/111 (52%), Gaps = 5/111 (4%) Frame = +2 Query: 83 RKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHILNWP 262 R+E L + H +L L AG P R+LV + G+L LLQ QD L Sbjct: 1918 RQELVVLCHLHHPSLISLLA--AGIRP--RMLVMELASKGSLDRLLQ----QDKASLTRT 1969 Query: 263 MRHLIALGVSRGLAFLHQSGVIHGDVKPQNILF-----DADFEPHLSDFGL 400 ++H IAL V+ GL +LH + +I+ D+KP N+L +A ++D+G+ Sbjct: 1970 LQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGI 2020
>LRRK2_HUMAN (Q5S007) Leucine-rich repeat serine/threonine-protein kinase 2 (EC| 2.7.11.1) (Dardarin) Length = 2527 Score = 47.8 bits (112), Expect = 2e-05 Identities = 38/111 (34%), Positives = 58/111 (52%), Gaps = 5/111 (4%) Frame = +2 Query: 83 RKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHILNWP 262 R+E L + H +L L AG P R+LV + G+L LLQ QD L Sbjct: 1918 RQELVVLCHLHHPSLISLLA--AGIRP--RMLVMELASKGSLDRLLQ----QDKASLTRT 1969 Query: 263 MRHLIALGVSRGLAFLHQSGVIHGDVKPQNILF-----DADFEPHLSDFGL 400 ++H IAL V+ GL +LH + +I+ D+KP N+L +A ++D+G+ Sbjct: 1970 LQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGI 2020
>FYN_CHICK (Q05876) Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2)| (p59-Fyn) Length = 533 Score = 47.8 bits (112), Expect = 2e-05 Identities = 32/112 (28%), Positives = 56/112 (50%) Frame = +2 Query: 77 SFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHILN 256 SF +EA+ + ++KH L L + P +V +YM G+L L++ +G L Sbjct: 306 SFLEEAQIMKKLKHDKLVQLYAVVSRRPI---YIVTEYMSKGSLLIFLKDG---EGRALK 359 Query: 257 WPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGLEPMV 412 P +A V+ G+A++ + IH D++ NIL ++DFGL ++ Sbjct: 360 LPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLI 411
>BTKL_DROME (P08630) Tyrosine-protein kinase Btk29A (EC 2.7.10.2) (Dsrc28C)| Length = 786 Score = 47.8 bits (112), Expect = 2e-05 Identities = 33/117 (28%), Positives = 61/117 (52%) Frame = +2 Query: 65 VEEGSFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDG 244 + E F +EA+ + +++H NL L G + P +V +YM +G+L L+ H+ Sbjct: 561 MSEDDFIEEAKVMTKLQHPNLVQLYGVCSKHRPIY--IVTEYMKHGSLLNYLRR--HEKT 616 Query: 245 HILNWPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGLEPMVV 415 I N + + + VS+G+ +L + IH D+ +N L ++ ++DFGL V+ Sbjct: 617 LIGNMGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLARYVL 673
>STK6_HUMAN (O14965) Serine/threonine-protein kinase 6 (EC 2.7.11.1)| (Serine/threonine kinase 15) (Aurora/IPL1-related kinase 1) (Aurora-related kinase 1) (hARK1) (Aurora-A) (Breast-tumor-amplified kinase) Length = 403 Score = 47.8 bits (112), Expect = 2e-05 Identities = 32/109 (29%), Positives = 51/109 (46%) Frame = +2 Query: 71 EGSFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHI 250 E R+E E ++H N+ L GY+ L+ +Y P G + LQ+ S D Sbjct: 175 EHQLRREVEIQSHLRHPNILRLYGYFHDATRVY--LILEYAPLGTVYRELQKLSKFDEQR 232 Query: 251 LNWPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFG 397 + L + L++ H VIH D+KP+N+L + E ++DFG Sbjct: 233 TATYITEL-----ANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFG 276
>SSP1_SCHPO (P50526) Serine/threonine-protein kinase ssp1 (EC 2.7.11.1)| Length = 652 Score = 47.8 bits (112), Expect = 2e-05 Identities = 32/106 (30%), Positives = 48/106 (45%) Frame = +2 Query: 83 RKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHILNWP 262 R+E L + H N+ LR P LV +YM G + + D +L+ Sbjct: 188 RREIAILKKCVHPNVVRLREVIDDPSSTKVYLVLEYMSGGEVPW-----TDCDSPVLSIS 242 Query: 263 MRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGL 400 V GL +LH G+IH D+KP N+L ++ +SDFG+ Sbjct: 243 EARQYFRDVVLGLEYLHYQGIIHRDIKPANLLLNSSNCVKISDFGV 288
>TOPK_BRARE (Q6DHU8) T-lymphokine-activated killer cell-originated protein| kinase homolog (EC 2.7.12.2) (PDZ-binding kinase) Length = 339 Score = 47.8 bits (112), Expect = 2e-05 Identities = 33/120 (27%), Positives = 58/120 (48%), Gaps = 1/120 (0%) Frame = +2 Query: 20 AILRLPSTSADGAVVVEEGSFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPN 199 AI ++ S A G V V + +EA+ L +KH N+ R + + L ++ Sbjct: 65 AIKKINSKCAQGQVSVYQKRLCEEAKILKDLKHPNIVGFRAFTTAKDGS-KCLAMEFGGE 123 Query: 200 GNLATLLQEASHQDGHILNWPMRHLIALGVSRGLAFLH-QSGVIHGDVKPQNILFDADFE 376 +L L+++ + +AL V+RGL +LH + ++HGD+K N++ DFE Sbjct: 124 QSLNDLIEKRREEGLQAFPVDTIEKVALHVARGLLYLHNEKKLLHGDMKSCNVVIKGDFE 183
>M3K1_HUMAN (Q13233) Mitogen-activated protein kinase kinase kinase 1 (EC| 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1) (Fragment) Length = 1495 Score = 47.8 bits (112), Expect = 2e-05 Identities = 38/135 (28%), Positives = 74/135 (54%), Gaps = 5/135 (3%) Frame = +2 Query: 8 GTVLAILRLP---STSADGAVVVEEGSFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLL 178 GT++A+ ++ +TS++ VVE + R+E + + H N+ + G A L Sbjct: 1249 GTLMAVKQVTYVRNTSSEQEEVVE--ALREEIRMMSHLNHPNIIRMLG--ATCEKSNYNL 1304 Query: 179 VYDYMPNGNLATLLQE-ASHQDGHILNWPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNI 355 ++M G++A LL + + ++ ++N+ + L RGL++LH++ +IH DVK N+ Sbjct: 1305 FIEWMAGGSVAHLLSKYGAFKESVVINYTEQLL------RGLSYLHENQIIHRDVKGANL 1358 Query: 356 LFDADFEP-HLSDFG 397 L D+ + ++DFG Sbjct: 1359 LIDSTGQRLRIADFG 1373
>YES_XENLA (P10936) Tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes)| Length = 536 Score = 47.8 bits (112), Expect = 2e-05 Identities = 31/112 (27%), Positives = 58/112 (51%) Frame = +2 Query: 77 SFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHILN 256 +F +EA+ + +++H L L YA + +V +YM G+L L+E + G L Sbjct: 309 AFLQEAQIMKKLRHDKLVPL---YAVVSEEPIYIVTEYMIKGSLLDFLKEGN---GKYLK 362 Query: 257 WPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGLEPMV 412 P +A ++ G+A++ + IH D++ NIL + ++DFGL ++ Sbjct: 363 LPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGDNLVCKIADFGLARLI 414
>HUNK_MOUSE (O88866) Hormonally up-regulated neu tumor-associated kinase (EC| 2.7.11.1) (Serine/threonine-protein kinase MAK-V) Length = 714 Score = 47.8 bits (112), Expect = 2e-05 Identities = 35/115 (30%), Positives = 52/115 (45%), Gaps = 7/115 (6%) Frame = +2 Query: 77 SFRKEAESLGRVKHRNLTVL-------RGYYAGPPPDVRLLVYDYMPNGNLATLLQEASH 235 + R+E + ++H N+T L YY LV + P GNL + E Sbjct: 107 NLRREGQIQQMIRHPNITQLLDILETENSYY---------LVMELCPGGNLMHKIYEKKR 157 Query: 236 QDGHILNWPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGL 400 D +R LI+ + LH++GV+H D+K +N+L D D L DFGL Sbjct: 158 LDEAEARRYIRQLIS-----AVEHLHRAGVVHRDLKIENLLLDEDNNIKLIDFGL 207
>PAK1_YEAST (P38990) Serine/threonine-protein kinase PAK1 (EC 2.7.11.1)| Length = 1142 Score = 47.8 bits (112), Expect = 2e-05 Identities = 30/116 (25%), Positives = 50/116 (43%), Gaps = 3/116 (2%) Frame = +2 Query: 62 VVEEGSFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQD 241 + E ++E + + H+++ L LV +Y G + + D Sbjct: 183 ISENDKIKREIAIMKKCHHKHVVQLIEVLDDLKSRKIYLVLEYCSRGEVKWCPPDCMESD 242 Query: 242 GH---ILNWPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGL 400 +L++ I GV GL +LH G+IH D+KP N+L D +SDFG+ Sbjct: 243 AKGPSLLSFQETREILRGVVLGLEYLHYQGIIHRDIKPANLLISGDGTVKISDFGV 298
>YES_AVISY (P00527) Tyrosine-protein kinase transforming protein YES (EC| 2.7.10.2) (Fragment) Length = 528 Score = 47.8 bits (112), Expect = 2e-05 Identities = 30/112 (26%), Positives = 58/112 (51%) Frame = +2 Query: 77 SFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHILN 256 +F +EA+ + +++H L L YA + +V ++M G+L L+E +G L Sbjct: 306 AFLQEAQIMKKLRHDKLVPL---YAVVSEEPIYIVTEFMTKGSLLDFLKEG---EGKFLK 359 Query: 257 WPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGLEPMV 412 P +A ++ G+A++ + IH D++ NIL + ++DFGL ++ Sbjct: 360 LPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGDNLVCKIADFGLARLI 411
>SRK1_SCHPO (O94547) Serine/threonine-protein kinase srk1 (EC 2.7.11.1)| (Sty1-regulated kinase 1) Length = 580 Score = 47.8 bits (112), Expect = 2e-05 Identities = 34/107 (31%), Positives = 55/107 (51%), Gaps = 2/107 (1%) Frame = +2 Query: 65 VEEGSFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDG 244 VE + KE + + RVKH N+ L + P+ LV + G L + ++ Sbjct: 173 VESHNILKEVQIMRRVKHPNIIQLLEFIQ--TPEYYYLVLELADGGELFHQIVRLTYFSE 230 Query: 245 HILNWPMRHLIALGVSRGLAFLHQS-GVIHGDVKPQNILFDA-DFEP 379 + RH+I V+ + +LH+ GV+H D+KP+N+LFD+ DF P Sbjct: 231 DL----SRHVITQ-VAHAIRYLHEDCGVVHRDIKPENLLFDSIDFVP 272
>JAK3_MOUSE (Q62137) Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3)| (JAK-3) Length = 1299 Score = 47.8 bits (112), Expect = 2e-05 Identities = 35/138 (25%), Positives = 65/138 (47%), Gaps = 3/138 (2%) Frame = +2 Query: 8 GTVLAILRLPSTSADGAVVVEEGSFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYD 187 G ++A+ +L + D ++ F++E + L + + RG GP LV + Sbjct: 1058 GPLVAVKQLQHSGPD-----QQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVME 1112 Query: 188 YMPNGNLATLLQE---ASHQDGHILNWPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNIL 358 Y+P+G L LQ A H D +L A + +G+ +L +H D+ +NIL Sbjct: 1113 YLPSGCLRDFLQRHRAALHTDRLLL-------FAWQICKGMEYLGARRCVHRDLAARNIL 1165 Query: 359 FDADFEPHLSDFGLEPMV 412 +++ ++DFGL ++ Sbjct: 1166 VESEAHVKIADFGLAKLL 1183 Score = 30.4 bits (67), Expect = 2.7 Identities = 29/120 (24%), Positives = 57/120 (47%), Gaps = 7/120 (5%) Frame = +2 Query: 77 SFRKEAESLGRVKHRNLTVLRGY-YAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHIL 253 SF + A + +V + +L +L G AG ++V +++ G + L++ GH++ Sbjct: 779 SFLEAASLMSQVSYPHLVLLHGVCMAGDS----IMVQEFVYLGAIDMYLRKR----GHLV 830 Query: 254 NWPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILF---DADFEP---HLSDFGLEPMVV 415 + + + ++ L +L G+ HG+V + +L D P LSD G+ P V+ Sbjct: 831 SASWKLQVTKQLAYALNYLEDKGLPHGNVSARKVLLAREGGDGNPPFIKLSDPGVSPTVL 890
>MLTK_MOUSE (Q9ESL4) Mitogen-activated protein kinase kinase kinase MLT (EC| 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper-and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) ( Length = 802 Score = 47.8 bits (112), Expect = 2e-05 Identities = 40/137 (29%), Positives = 63/137 (45%), Gaps = 7/137 (5%) Frame = +2 Query: 8 GTVLAILRLPSTSADGAVVVEEG-SFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVY 184 G+ ++ R S D V V++ KEAE L + HRN+ G PP +V Sbjct: 25 GSFGSVYRAKWISQDKEVAVKKLLKIEKEAEILSVLSHRNIIQFYGVILEPPNYG--IVT 82 Query: 185 DYMPNGNLATLLQEASHQD---GHILNWPMRHLIALGVSRGLAFLHQSG---VIHGDVKP 346 +Y G+L + ++ HI+ W A V++G+ +LH VIH D+K Sbjct: 83 EYASLGSLYDYINSNRSEEMDMEHIMTW------ATDVAKGMHYLHMEAPVKVIHRDLKS 136 Query: 347 QNILFDADFEPHLSDFG 397 +N++ AD + DFG Sbjct: 137 RNVVIAADGVLKICDFG 153
>STE20_CANAL (Q92212) Serine/threonine-protein kinase STE20 homolog (EC 2.7.11.1)| Length = 1230 Score = 47.4 bits (111), Expect = 2e-05 Identities = 24/74 (32%), Positives = 39/74 (52%) Frame = +2 Query: 176 LVYDYMPNGNLATLLQEASHQDGHILNWPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNI 355 ++ +YM G+L ++ + +G I ++ +GL FLH GVIH D+K NI Sbjct: 1026 VIMEYMEGGSLTDIVTHSVMTEGQI------GVVCRETLKGLKFLHSKGVIHRDIKSDNI 1079 Query: 356 LFDADFEPHLSDFG 397 L + D ++DFG Sbjct: 1080 LLNMDGNIKITDFG 1093
>PCTK2_RAT (O35831) Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22)| (PCTAIRE-motif protein kinase 2) Length = 523 Score = 47.4 bits (111), Expect = 2e-05 Identities = 34/106 (32%), Positives = 52/106 (49%), Gaps = 1/106 (0%) Frame = +2 Query: 86 KEAESLGRVKHRNLTVLRGYYAGPPPDVRL-LVYDYMPNGNLATLLQEASHQDGHILNWP 262 +E L +KH N+ L D L LV++Y+ L++ G I++ Sbjct: 237 REVSLLKDLKHANIVTLHDIVH---TDKSLTLVFEYLDKD-----LKQYMDDCGSIMSMH 288 Query: 263 MRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGL 400 L + RGLA+ H+ V+H D+KPQN+L + E L+DFGL Sbjct: 289 NVKLFLYQILRGLAYCHRRKVLHRDLKPQNLLINERGELKLADFGL 334
>SGK2_HUMAN (Q9HBY8) Serine/threonine-protein kinase Sgk2 (EC 2.7.11.1)| (Serum/glucocorticoid-regulated kinase 2) Length = 427 Score = 47.4 bits (111), Expect = 2e-05 Identities = 34/100 (34%), Positives = 48/100 (48%) Frame = +2 Query: 101 LGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHILNWPMRHLIA 280 L V+H L LR Y+ P+ V DY+ G L LQ ++ L P A Sbjct: 148 LKNVRHPFLVGLR--YSFQTPEKLYFVLDYVNGGELFFHLQ----RERRFLE-PRARFYA 200 Query: 281 LGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGL 400 V+ + +LH +I+ D+KP+NIL D L+DFGL Sbjct: 201 AEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGL 240
>PKNB_MYCLE (P54744) Probable serine/threonine-protein kinase pknB (EC| 2.7.11.1) Length = 622 Score = 47.4 bits (111), Expect = 2e-05 Identities = 33/112 (29%), Positives = 54/112 (48%), Gaps = 5/112 (4%) Frame = +2 Query: 80 FRKEAESLGRVKHRNLTVLRGY-----YAGPPPDVRLLVYDYMPNGNLATLLQEASHQDG 244 FR+EA++ + H ++ + AGP P +V +Y+ L ++ H DG Sbjct: 56 FRREAQNAAALNHPSIVAVYDTGEAETSAGPLP---YIVMEYVDGATLRDIV----HTDG 108 Query: 245 HILNWPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGL 400 + ++A + L F HQ+G+IH DVKP NI+ A + DFG+ Sbjct: 109 PMPPQQAIEIVA-DACQALNFSHQNGIIHRDVKPANIMISATNAVKVMDFGI 159
>PKN2_BACSU (O34507) Probable serine/threonine-protein kinase yloP (EC| 2.7.11.1) Length = 648 Score = 47.4 bits (111), Expect = 2e-05 Identities = 31/111 (27%), Positives = 51/111 (45%), Gaps = 4/111 (3%) Frame = +2 Query: 80 FRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHILNW 259 FR+EA+S + H N+ + Y G D+ +V +Y+ L + N Sbjct: 56 FRREAQSASSLDHPNIVSI--YDLGEEDDIYYIVMEYVEGMTLKEYITA---------NG 104 Query: 260 PMRHLIALGVSR----GLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGL 400 P+ AL + +A HQ+ ++H D+KP NIL D ++DFG+ Sbjct: 105 PLHPKEALNIMEQIVSAIAHAHQNQIVHRDIKPHNILIDHMGNIKVTDFGI 155
>SPKC_SYNY3 (P74745) Serine/threonine-protein kinase C (EC 2.7.11.1)| Length = 535 Score = 47.4 bits (111), Expect = 2e-05 Identities = 35/110 (31%), Positives = 58/110 (52%), Gaps = 3/110 (2%) Frame = +2 Query: 80 FRKEAESLGRV--KHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHIL 253 F +EA +L + H + L Y++ + LV +++P L +A Q G+ Sbjct: 62 FHREAATLEELGENHPQIPQLYAYFS--EGEDFYLVQEWIPG----LTLTQAHAQKGNFS 115 Query: 254 NWPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILF-DADFEPHLSDFGL 400 + + L+ LG+ L F+HQ +IH D+KP NI+ +AD +P L DFG+ Sbjct: 116 STAVEELL-LGILPVLEFIHQRRIIHRDIKPDNIILREADGKPILIDFGI 164
>SGK2_RAT (Q8R4U9) Serine/threonine-protein kinase Sgk2 (EC 2.7.11.1)| (Serum/glucocorticoid-regulated kinase 2) (Fragment) Length = 302 Score = 47.4 bits (111), Expect = 2e-05 Identities = 33/100 (33%), Positives = 45/100 (45%) Frame = +2 Query: 101 LGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHILNWPMRHLIA 280 L V+H L LR Y+ P+ V DY+ G L LQ H P Sbjct: 71 LKNVRHPFLVGLR--YSFQTPEKLYFVLDYVNGGELFFHLQRE-----HRFLEPRARFYT 123 Query: 281 LGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGL 400 V+ + +LH +I+ D+KP+NIL D L+DFGL Sbjct: 124 AEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGL 163
>PKNK_MYCTU (P95078) Probable serine/threonine-protein kinase pknK (EC| 2.7.11.1) Length = 1110 Score = 47.4 bits (111), Expect = 2e-05 Identities = 37/110 (33%), Positives = 56/110 (50%), Gaps = 3/110 (2%) Frame = +2 Query: 80 FRKEAESLGRVK-HRNL-TVLR-GYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHI 250 F +E ++GR+ H ++ TVL+ G AG P +V Y +L TL++ Sbjct: 69 FLREQRAMGRLSGHPHIVTVLQVGVLAGGRP---FIVMPYHAKNSLETLIRRHGP----- 120 Query: 251 LNWPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGL 400 L+W I + ++ L H+ G +H DVKP NIL EP L+DFG+ Sbjct: 121 LDWRETLSIGVKLAGALEAAHRVGTLHRDVKPGNILLTDYGEPQLTDFGI 170
>PKNK_MYCBO (Q7TXA9) Probable serine/threonine-protein kinase pknK (EC| 2.7.11.1) Length = 1110 Score = 47.4 bits (111), Expect = 2e-05 Identities = 37/110 (33%), Positives = 56/110 (50%), Gaps = 3/110 (2%) Frame = +2 Query: 80 FRKEAESLGRVK-HRNL-TVLR-GYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHI 250 F +E ++GR+ H ++ TVL+ G AG P +V Y +L TL++ Sbjct: 69 FLREQRAMGRLSGHPHIVTVLQVGVLAGGRP---FIVMPYHAKNSLETLIRRHGP----- 120 Query: 251 LNWPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGL 400 L+W I + ++ L H+ G +H DVKP NIL EP L+DFG+ Sbjct: 121 LDWRETLSIGVKLAGALEAAHRVGTLHRDVKPGNILLTDYGEPQLTDFGI 170
>PHO85_YARLI (Q6C7U8) Negative regulator of the PHO system (EC 2.7.11.22)| (Serine/threonine-protein kinase PHO85) Length = 294 Score = 47.4 bits (111), Expect = 2e-05 Identities = 42/142 (29%), Positives = 65/142 (45%), Gaps = 11/142 (7%) Frame = +2 Query: 8 GTVLAILRLPSTSADG--AVVVEEGSFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLV 181 G ++A+ + S +G + + E S KE +KH N+ L Y + LV Sbjct: 30 GQLVALKEINLDSEEGTPSTAIREISLMKE------LKHENIVTL--YDVIHTENKLNLV 81 Query: 182 YDYMP---------NGNLATLLQEASHQDGHILNWPMRHLIALGVSRGLAFLHQSGVIHG 334 ++YM NGN L + + W M L+ RG+ F H + V+H Sbjct: 82 FEYMDKDLKKFMDTNGNKGALETKQ-------VKWFMYQLL-----RGILFCHDNRVLHR 129 Query: 335 DVKPQNILFDADFEPHLSDFGL 400 D+KPQN+L +A + L+DFGL Sbjct: 130 DLKPQNLLINAKGQLKLADFGL 151
>PCTK3_RAT (O35832) Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22)| (PCTAIRE-motif protein kinase 3) Length = 451 Score = 47.4 bits (111), Expect = 2e-05 Identities = 32/106 (30%), Positives = 54/106 (50%), Gaps = 1/106 (0%) Frame = +2 Query: 86 KEAESLGRVKHRNLTVLRGYYAGPPPDVRL-LVYDYMPNGNLATLLQEASHQDGHILNWP 262 +E L +KH N+ L D L LV++Y+ + L++ G+++N Sbjct: 166 REVSLLKDLKHANIVTLHDLIH---TDRSLTLVFEYLDSD-----LKQYLDHCGNLMNMH 217 Query: 263 MRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGL 400 + + RGLA+ H+ ++H D+KPQN+L + E L+DFGL Sbjct: 218 NVKIFMFQLLRGLAYCHRRKILHRDLKPQNLLINERGELKLADFGL 263
>ANPRB_ANGJA (P55202) Atrial natriuretic peptide receptor B precursor (ANP-B)| (ANPRB) (GC-B) (Guanylate cyclase) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor) Length = 1050 Score = 47.4 bits (111), Expect = 2e-05 Identities = 26/82 (31%), Positives = 47/82 (57%), Gaps = 1/82 (1%) Frame = +2 Query: 158 PPDVRLLVYDYMPNGNLATLLQEASHQDGHILNWPMRHLIALGVSRGLAFLHQSGV-IHG 334 PP++ +V +Y P G+L +L+ S L+W R+ + + +G+ FLH S + HG Sbjct: 593 PPNI-CIVTEYCPRGSLQDILENESIN----LDWMFRYSLINDIVKGMNFLHNSYIGSHG 647 Query: 335 DVKPQNILFDADFEPHLSDFGL 400 ++K N + D+ F ++D+GL Sbjct: 648 NLKSSNCVVDSRFVLKITDYGL 669
>M4K4_MOUSE (P97820) Mitogen-activated protein kinase kinase kinase kinase 4| (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase) Length = 1233 Score = 47.4 bits (111), Expect = 2e-05 Identities = 40/135 (29%), Positives = 60/135 (44%), Gaps = 5/135 (3%) Frame = +2 Query: 11 TVLAILRLPSTSADGAVVVEEGSFRKEAESLGRVKH-RNLTVLRGYYAGPPP----DVRL 175 TV A +++ + D EE E L + H RN+ G + P D Sbjct: 47 TVTAAIKVMDVTED-----EEEEITLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLW 101 Query: 176 LVYDYMPNGNLATLLQEASHQDGHILNWPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNI 355 LV ++ G++ L++ G+ L I+ + RGLA LH VIH D+K QN+ Sbjct: 102 LVMEFCGAGSITDLVKNTK---GNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNV 158 Query: 356 LFDADFEPHLSDFGL 400 L + E L DFG+ Sbjct: 159 LLTENAEVKLVDFGV 173
>RIPK5_BRARE (Q4VSN1) Receptor-interacting serine/threonine-protein kinase 5 (EC| 2.7.11.1) (Dusty protein kinase) (Dusty PK) Length = 885 Score = 47.4 bits (111), Expect = 2e-05 Identities = 35/109 (32%), Positives = 50/109 (45%), Gaps = 14/109 (12%) Frame = +2 Query: 113 KHRNLTVLRGYYAGPPPDVRLLV--------YDYMPNGNLATLL-QEASHQDGHI----- 250 KH N L +Y P LV + Y ++A LL E H+D + Sbjct: 651 KHWNDLALEFHYTRSLPKHERLVNLHGSVIDHSYSGGSSIAVLLIMERLHRDLYTGLKAG 710 Query: 251 LNWPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFG 397 L+ R LIAL V G+ FLH G++H D+K +N+L D ++D G Sbjct: 711 LSLKERLLIALDVVEGIRFLHSQGLLHRDIKLKNVLLDKQNRAKITDLG 759
>CEK1_SCHPO (P38938) Serine/threonine-protein kinase cek1 (EC 2.7.11.1)| Length = 1338 Score = 47.4 bits (111), Expect = 2e-05 Identities = 33/90 (36%), Positives = 47/90 (52%) Frame = +2 Query: 131 VLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHILNWPMRHLIALGVSRGLAFL 310 V + YY D LV +Y+ G+ +LL+ D L+W +R IA V L L Sbjct: 650 VAKLYYTFQSKDYLYLVMEYLNGGDCGSLLKTMGVLD---LDW-IRTYIAETVLC-LGDL 704 Query: 311 HQSGVIHGDVKPQNILFDADFEPHLSDFGL 400 H G+IH D+KP+N+L + L+DFGL Sbjct: 705 HDRGIIHRDIKPENLLISQNGHLKLTDFGL 734
>M4K4_HUMAN (O95819) Mitogen-activated protein kinase kinase kinase kinase 4| (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase) Length = 1239 Score = 47.0 bits (110), Expect = 3e-05 Identities = 36/116 (31%), Positives = 53/116 (45%), Gaps = 5/116 (4%) Frame = +2 Query: 68 EEGSFRKEAESLGRVKH-RNLTVLRGYYAGPPP----DVRLLVYDYMPNGNLATLLQEAS 232 EE + E L + H RN+ G + P D LV ++ G++ L++ Sbjct: 62 EEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTK 121 Query: 233 HQDGHILNWPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGL 400 G+ L I+ + RGLA LH VIH D+K QN+L + E L DFG+ Sbjct: 122 ---GNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGV 174
>GSK3B_RAT (P18266) Glycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3| beta) (Factor A) (FA) Length = 420 Score = 47.0 bits (110), Expect = 3e-05 Identities = 40/126 (31%), Positives = 65/126 (51%), Gaps = 8/126 (6%) Frame = +2 Query: 62 VVEEGSFR-KEAESLGRVKHRNLTVLRGYY--AGPPPD-VRL-LVYDYMPNGNLATLLQE 226 V+++ F+ +E + + ++ H N+ LR ++ +G D V L LV DY+P T+ + Sbjct: 87 VLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPE----TVYRV 142 Query: 227 ASHQDGHILNWPMRH--LIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEP-HLSDFG 397 A H P+ + L + R LA++H G+ H D+KPQN+L D D L DFG Sbjct: 143 ARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFG 202 Query: 398 LEPMVV 415 +V Sbjct: 203 SAKQLV 208
>GSK3B_MOUSE (Q9WV60) Glycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3| beta) Length = 420 Score = 47.0 bits (110), Expect = 3e-05 Identities = 40/126 (31%), Positives = 65/126 (51%), Gaps = 8/126 (6%) Frame = +2 Query: 62 VVEEGSFR-KEAESLGRVKHRNLTVLRGYY--AGPPPD-VRL-LVYDYMPNGNLATLLQE 226 V+++ F+ +E + + ++ H N+ LR ++ +G D V L LV DY+P T+ + Sbjct: 87 VLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPE----TVYRV 142 Query: 227 ASHQDGHILNWPMRH--LIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEP-HLSDFG 397 A H P+ + L + R LA++H G+ H D+KPQN+L D D L DFG Sbjct: 143 ARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFG 202 Query: 398 LEPMVV 415 +V Sbjct: 203 SAKQLV 208
>GSK3B_HUMAN (P49841) Glycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3| beta) Length = 420 Score = 47.0 bits (110), Expect = 3e-05 Identities = 40/126 (31%), Positives = 65/126 (51%), Gaps = 8/126 (6%) Frame = +2 Query: 62 VVEEGSFR-KEAESLGRVKHRNLTVLRGYY--AGPPPD-VRL-LVYDYMPNGNLATLLQE 226 V+++ F+ +E + + ++ H N+ LR ++ +G D V L LV DY+P T+ + Sbjct: 87 VLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPE----TVYRV 142 Query: 227 ASHQDGHILNWPMRH--LIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEP-HLSDFG 397 A H P+ + L + R LA++H G+ H D+KPQN+L D D L DFG Sbjct: 143 ARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFG 202 Query: 398 LEPMVV 415 +V Sbjct: 203 SAKQLV 208
>EPHB2_HUMAN (P29323) Ephrin type-B receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EPH-3) (DRT) (Receptor protein-tyrosine kinase HEK5) (ERK) (NY-REN-47 antigen) Length = 1055 Score = 47.0 bits (110), Expect = 3e-05 Identities = 31/122 (25%), Positives = 59/122 (48%), Gaps = 2/122 (1%) Frame = +2 Query: 41 TSADGAVVVEEGSFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLL 220 T G + F EA +G+ H N+ L G P +++ ++M NG+L + L Sbjct: 654 TLKSGYTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPV--MIITEFMENGSLDSFL 711 Query: 221 QEASHQDGHILNWPMRHLIAL--GVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDF 394 ++ Q + + L+ + G++ G+ +L +H D+ +NIL +++ +SDF Sbjct: 712 RQNDGQ------FTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDF 765 Query: 395 GL 400 GL Sbjct: 766 GL 767
>MKK2_YEAST (P32491) MAP kinase kinase MKK2/SSP33 (EC 2.7.12.2)| Length = 506 Score = 47.0 bits (110), Expect = 3e-05 Identities = 23/42 (54%), Positives = 29/42 (69%) Frame = +2 Query: 275 IALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGL 400 IA V RGL++LH+ VIH D+KPQNIL + E L DFG+ Sbjct: 322 IAESVLRGLSYLHERKVIHRDIKPQNILLNEKGEIKLCDFGV 363
>HOG1_DEBHA (Q9UV50) Mitogen-activated protein kinase HOG1 (EC 2.7.11.24) (MAP| kinase HOG1) Length = 387 Score = 47.0 bits (110), Expect = 3e-05 Identities = 31/105 (29%), Positives = 51/105 (48%) Frame = +2 Query: 86 KEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHILNWPM 265 +E + L ++H NL L + P D+ + + +L LL + I + Sbjct: 69 RELKLLKHLRHENLITLDDIFLSPLEDIYFVTE--LQGTDLHRLLTSRPLEKQFIQYFTY 126 Query: 266 RHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGL 400 + L RGL ++H +GVIH D+KP NIL + + + + DFGL Sbjct: 127 QIL------RGLKYVHSAGVIHRDLKPSNILINENCDLKICDFGL 165
>EPHA7_RAT (P54759) Ephrin type-A receptor 7 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) Length = 998 Score = 47.0 bits (110), Expect = 3e-05 Identities = 31/113 (27%), Positives = 57/113 (50%), Gaps = 2/113 (1%) Frame = +2 Query: 80 FRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHILNW 259 F EA +G+ H N+ L G P ++V ++M NG L L++ Q + Sbjct: 679 FLCEASIMGQFDHPNVVHLEGVVTRGKPV--MIVIEFMENGALDAFLRKHDGQ------F 730 Query: 260 PMRHLIAL--GVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGLEPMV 412 + L+ + G++ G+ +L G +H D+ +NIL +++ +SDFGL ++ Sbjct: 731 TVIQLVGMLRGIAAGMRYLADMGYVHRDLAARNILVNSNLVCKVSDFGLSRVI 783
>EPHA7_MOUSE (Q61772) Ephrin type-A receptor 7 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Embryonic brain kinase) (EBK) (Developmental kinase 1) (MDK-1) Length = 998 Score = 47.0 bits (110), Expect = 3e-05 Identities = 31/113 (27%), Positives = 57/113 (50%), Gaps = 2/113 (1%) Frame = +2 Query: 80 FRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHILNW 259 F EA +G+ H N+ L G P ++V ++M NG L L++ Q + Sbjct: 679 FLCEASIMGQFDHPNVVHLEGVVTRGKPV--MIVIEFMENGALDAFLRKHDGQ------F 730 Query: 260 PMRHLIAL--GVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGLEPMV 412 + L+ + G++ G+ +L G +H D+ +NIL +++ +SDFGL ++ Sbjct: 731 TVIQLVGMLRGIAAGMRYLADMGYVHRDLAARNILVNSNLVCKVSDFGLSRVI 783
>EPHA7_HUMAN (Q15375) Ephrin type-A receptor 7 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Receptor protein-tyrosine kinase HEK11) Length = 998 Score = 47.0 bits (110), Expect = 3e-05 Identities = 31/113 (27%), Positives = 57/113 (50%), Gaps = 2/113 (1%) Frame = +2 Query: 80 FRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHILNW 259 F EA +G+ H N+ L G P ++V ++M NG L L++ Q + Sbjct: 679 FLCEASIMGQFDHPNVVHLEGVVTRGKPV--MIVIEFMENGALDAFLRKHDGQ------F 730 Query: 260 PMRHLIAL--GVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGLEPMV 412 + L+ + G++ G+ +L G +H D+ +NIL +++ +SDFGL ++ Sbjct: 731 TVIQLVGMLRGIAAGMRYLADMGYVHRDLAARNILVNSNLVCKVSDFGLSRVI 783
>SRC64_DROME (P00528) Tyrosine-protein kinase Src64B (EC 2.7.10.2) (Dsrc64)| Length = 552 Score = 47.0 bits (110), Expect = 3e-05 Identities = 31/112 (27%), Positives = 54/112 (48%) Frame = +2 Query: 77 SFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHILN 256 +F +EA + + +H L L + P +V +YM G+L L+E DG L+ Sbjct: 323 AFLQEAAIMKKFRHNRLVALYAVCSQEEPIY--IVQEYMSKGSLLDFLREG---DGRYLH 377 Query: 257 WPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGLEPMV 412 + IA V+ G+ +L +IH D+ +N+L + + DFGL ++ Sbjct: 378 FEDLIYIATQVASGMEYLESKQLIHRDLAARNVLIGENNVAKICDFGLARVI 429
>EPHB2_MOUSE (P54763) Ephrin type-B receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EPH-3) (Neural kinase) (Nuk receptor tyrosine kinase) (SEK-3) Length = 994 Score = 47.0 bits (110), Expect = 3e-05 Identities = 31/122 (25%), Positives = 59/122 (48%), Gaps = 2/122 (1%) Frame = +2 Query: 41 TSADGAVVVEEGSFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLL 220 T G + F EA +G+ H N+ L G P +++ ++M NG+L + L Sbjct: 662 TLKSGYTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPV--MIITEFMENGSLDSFL 719 Query: 221 QEASHQDGHILNWPMRHLIAL--GVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDF 394 ++ Q + + L+ + G++ G+ +L +H D+ +NIL +++ +SDF Sbjct: 720 RQNDGQ------FTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDF 773 Query: 395 GL 400 GL Sbjct: 774 GL 775
>FGR_FSVGR (P00544) Tyrosine-protein kinase transforming protein Fgr (EC| 2.7.10.2) Length = 545 Score = 47.0 bits (110), Expect = 3e-05 Identities = 31/109 (28%), Positives = 57/109 (52%) Frame = +2 Query: 86 KEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHILNWPM 265 +EA+ + ++H L L YA P + +V ++M +G+L L++ Q+G L P Sbjct: 328 EEAQIMKLLRHDKLVQL---YAVVPEEPIYIVTEFMCHGSLLEFLKD---QEGQDLTLPQ 381 Query: 266 RHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGLEPMV 412 +A V+ G+A++ + IH D++ NIL ++DFGL ++ Sbjct: 382 LVDMAAQVAEGMAYMERMDYIHRDLRAANILVGERLVCKIADFGLARLI 430
>PHKG2_HUMAN (P15735) Phosphorylase b kinase gamma catalytic chain, testis/liver| isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase gamma subunit 2) (PSK-C3) Length = 406 Score = 47.0 bits (110), Expect = 3e-05 Identities = 30/81 (37%), Positives = 41/81 (50%), Gaps = 4/81 (4%) Frame = +2 Query: 176 LVYDYMPNGNLATLLQEASHQDGHILNWPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNI 355 LV+D M G L L E MR L+ ++FLH + ++H D+KP+NI Sbjct: 105 LVFDLMRKGELFDYLTEKVALSEKETRSIMRSLL-----EAVSFLHANNIVHRDLKPENI 159 Query: 356 LFDADFEPHLSDFG----LEP 406 L D + + LSDFG LEP Sbjct: 160 LLDDNMQIRLSDFGFSCHLEP 180
>PCTK3_MOUSE (Q04899) Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22)| (PCTAIRE-motif protein kinase 3) Length = 451 Score = 47.0 bits (110), Expect = 3e-05 Identities = 32/106 (30%), Positives = 53/106 (50%), Gaps = 1/106 (0%) Frame = +2 Query: 86 KEAESLGRVKHRNLTVLRGYYAGPPPDVRL-LVYDYMPNGNLATLLQEASHQDGHILNWP 262 +E L +KH N+ L D L LV++Y+ + L++ G+++N Sbjct: 166 REVSLLKDLKHANIVTLHDLIH---TDRSLTLVFEYLDSD-----LKQYLDHCGNLMNMH 217 Query: 263 MRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGL 400 + + RGLA+ H ++H D+KPQN+L + E L+DFGL Sbjct: 218 NVKIFMFQLLRGLAYCHHRKILHRDLKPQNLLINERGELKLADFGL 263
>PFTK1_MOUSE (O35495) Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22)| Length = 469 Score = 47.0 bits (110), Expect = 3e-05 Identities = 33/105 (31%), Positives = 56/105 (53%) Frame = +2 Query: 86 KEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHILNWPM 265 +EA L +KH N+ +L + LV++Y+ + +L +++ H G L+ Sbjct: 180 REASLLKGLKHANIVLLHDIIH--TKETLTLVFEYV-HTDLCQYMEQ--HPGG--LHPDN 232 Query: 266 RHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGL 400 L + RGL+++HQ ++H D+KPQN+L E L+DFGL Sbjct: 233 VKLFLFQLLRGLSYIHQRYILHRDLKPQNLLISDTGELKLADFGL 277
>EPHB2_CHICK (P28693) Ephrin type-B receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor CEK5) Length = 1004 Score = 47.0 bits (110), Expect = 3e-05 Identities = 31/122 (25%), Positives = 59/122 (48%), Gaps = 2/122 (1%) Frame = +2 Query: 41 TSADGAVVVEEGSFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLL 220 T G + F EA +G+ H N+ L G P +++ ++M NG+L + L Sbjct: 672 TLKSGYTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSSPV--MIITEFMENGSLDSFL 729 Query: 221 QEASHQDGHILNWPMRHLIAL--GVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDF 394 ++ Q + + L+ + G++ G+ +L +H D+ +NIL +++ +SDF Sbjct: 730 RQNDGQ------FTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDF 783 Query: 395 GL 400 GL Sbjct: 784 GL 785
>EPHA8_MOUSE (O09127) Ephrin type-A receptor 8 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) Length = 1004 Score = 47.0 bits (110), Expect = 3e-05 Identities = 33/109 (30%), Positives = 52/109 (47%), Gaps = 2/109 (1%) Frame = +2 Query: 80 FRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHILNW 259 F EA +G+ H N+ L G + ++V +YM NG+L L+ Q + Sbjct: 680 FLSEAAIMGQFDHPNIIRLEGVVTRGR--LAMIVTEYMENGSLDAFLRTHDGQ------F 731 Query: 260 PMRHLIAL--GVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGL 400 + L+ + GV G+ +L G IH D+ +N+L D +SDFGL Sbjct: 732 TIVQLVGMLRGVGAGMRYLSDLGYIHRDLAARNVLVDGRLVCKVSDFGL 780
>AURKC_HUMAN (Q9UQB9) Serine/threonine-protein kinase 13 (EC 2.7.11.1)| (Aurora/Ipl1/Eg2 protein 2) (Aurora/Ipl1-related kinase 3) (Aurora-C) Length = 309 Score = 46.6 bits (109), Expect = 4e-05 Identities = 33/111 (29%), Positives = 50/111 (45%), Gaps = 2/111 (1%) Frame = +2 Query: 71 EGSFRKEAESLGRVKHRNLTVLRGYYAGPPPDVR--LLVYDYMPNGNLATLLQEASHQDG 244 E R+E E ++H N+ L Y+ D R L+ +Y P G L LQ++ D Sbjct: 85 EHQLRREIEIQAHLQHPNILRLYNYFH----DARRVYLILEYAPRGELYKELQKSEKLDE 140 Query: 245 HILNWPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFG 397 + L + L + H VIH D+KP+N+L E ++DFG Sbjct: 141 QRTATIIEEL-----ADALTYCHDKKVIHRDIKPENLLLGFRGEVKIADFG 186
>PK1_STRTO (Q9KIG4) Serine/threonine-protein kinase PK-1 (EC 2.7.11.1)| (stoPK-1) Length = 641 Score = 46.6 bits (109), Expect = 4e-05 Identities = 38/123 (30%), Positives = 62/123 (50%), Gaps = 1/123 (0%) Frame = +2 Query: 35 PSTSADGAVVVEEGSFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLAT 214 PS +AD + V F +EA+S+ R+ H N V++ + G L +Y+ L Sbjct: 51 PSLAADASFVER---FIREAKSVARLAHPN--VVQVFDQGTDGAYVYLAMEYIAGCTLRD 105 Query: 215 LLQE-ASHQDGHILNWPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSD 391 +L+E + Q L+ L ALG + H++G +H D+KP+N+L D ++D Sbjct: 106 VLRERGALQPRAALDILEPVLAALGAA------HRAGFVHRDMKPENVLIGDDGRVKVAD 159 Query: 392 FGL 400 FGL Sbjct: 160 FGL 162
>RIPK5_HUMAN (Q6XUX3) Receptor-interacting serine/threonine-protein kinase 5 (EC| 2.7.11.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase) Length = 929 Score = 46.6 bits (109), Expect = 4e-05 Identities = 35/109 (32%), Positives = 49/109 (44%), Gaps = 14/109 (12%) Frame = +2 Query: 113 KHRNLTVLRGYYAGPPPDVRLLV--------YDYMPNGNLATLL-QEASHQDGHI----- 250 KH N L +Y P LV Y+Y ++A LL E H+D + Sbjct: 689 KHWNDLALEFHYMRSLPKHERLVDLHGSVIDYNYGGGSSIAVLLIMERLHRDLYTGLKAG 748 Query: 251 LNWPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFG 397 L R IAL V G+ FLH G++H D+K +N+L D ++D G Sbjct: 749 LTLETRLQIALDVVEGIRFLHSQGLVHRDIKLKNVLLDKQNRAKITDLG 797
>CDS1_SCHPO (Q09170) Serine/threonine-protein kinase cds1 (EC 2.7.11.1)| (Checkpoint kinase cds1) Length = 460 Score = 46.6 bits (109), Expect = 4e-05 Identities = 31/111 (27%), Positives = 50/111 (45%) Frame = +2 Query: 80 FRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHILNW 259 F++E + L + H + + D +V +Y+ G+L L D Sbjct: 216 FQREIDILKSLHHPGVVQCHEIFEND--DELFIVMEYVEGGDLMDFLIANGSIDEQDCKP 273 Query: 260 PMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGLEPMV 412 ++ L+ L LH+ GV H D+KP+NIL DF +SDFGL ++ Sbjct: 274 LLKQLLET-----LLHLHKQGVTHRDIKPENILITNDFHLKISDFGLAKVI 319
>TESK2_HUMAN (Q96S53) Dual specificity testis-specific protein kinase 2 (EC| 2.7.12.1) (Testicular protein kinase 2) Length = 571 Score = 46.6 bits (109), Expect = 4e-05 Identities = 32/108 (29%), Positives = 51/108 (47%), Gaps = 3/108 (2%) Frame = +2 Query: 86 KEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHILNWPM 265 KE + + R+ H N+ G L +Y+ +GNL LL H L W + Sbjct: 100 KEVQLMNRLSHPNILRFMGVCVHQGQLHALT--EYINSGNLEQLLDSNLH-----LPWTV 152 Query: 266 RHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDAD---FEPHLSDFGL 400 R +A ++ GL++LH G+ H D+ +N L D + ++DFGL Sbjct: 153 RVKLAYDIAVGLSYLHFKGIFHRDLTSKNCLIKRDENGYSAVVADFGL 200
>CHK1_SCHPO (P34208) Serine/threonine-protein kinase chk1 (EC 2.7.11.1)| (Checkpoint kinase 1) Length = 496 Score = 46.6 bits (109), Expect = 4e-05 Identities = 27/94 (28%), Positives = 46/94 (48%) Frame = +2 Query: 116 HRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHILNWPMRHLIALGVSR 295 H+N ++ Y P R +V ++ G+L ++ D + + L+ Sbjct: 71 HKN--IIHFYNTAENPQWRWVVLEFAQGGDLFDKIEPDVGIDEDVAQFYFAQLM-----E 123 Query: 296 GLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFG 397 G++F+H GV H D+KP+NIL D + +SDFG Sbjct: 124 GISFMHSKGVAHRDLKPENILLDYNGNLKISDFG 157
>M3K3_ARATH (O22042) Mitogen-activated protein kinase kinase kinase 3 (EC| 2.7.11.25) (Arabidospsis NPK1-related protein kinase 3) Length = 651 Score = 46.6 bits (109), Expect = 4e-05 Identities = 37/140 (26%), Positives = 69/140 (49%), Gaps = 4/140 (2%) Frame = +2 Query: 8 GTVLAILRLPSTSADGAVVVEEGSFRK---EAESLGRVKHRNLTVLRGYYAGPPPDVRLL 178 G +LAI ++ + + +G R+ E + L + H N+ G D + Sbjct: 91 GELLAIKQVLIAPSSASKEKTQGHIRELEEEVQLLKNLSHPNIVRYLGTVR--ESDSLNI 148 Query: 179 VYDYMPNGNLATLLQE-ASHQDGHILNWPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNI 355 + +++P G++++LL++ S + I+ + + L+ GL +LH +G++H D+K NI Sbjct: 149 LMEFVPGGSISSLLEKFGSFPEPVIIMYTKQLLL------GLEYLHNNGIMHRDIKGANI 202 Query: 356 LFDADFEPHLSDFGLEPMVV 415 L D L+DFG VV Sbjct: 203 LVDNKGCIRLADFGASKKVV 222
>ANKK1_MOUSE (Q8BZ25) Ankyrin repeat and protein kinase domain-containing| protein 1 (EC 2.7.11.1) Length = 745 Score = 46.6 bits (109), Expect = 4e-05 Identities = 32/107 (29%), Positives = 54/107 (50%), Gaps = 2/107 (1%) Frame = +2 Query: 86 KEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHILNWPM 265 +EA + ++K +++ + G P +V ++M +G+L L H L WP+ Sbjct: 82 EEAVKMEKIKFQHIVSIYGVCKQPLG----IVMEFMASGSLEKTLPT------HSLCWPL 131 Query: 266 RHLIALGVSRGLAFLH--QSGVIHGDVKPQNILFDADFEPHLSDFGL 400 + I S + FLH + ++H D+KP NIL D + +SDFGL Sbjct: 132 KLRIIHETSLAMNFLHSIKPPLLHLDLKPGNILLDNNMHVKISDFGL 178
>PHKG2_RAT (P31325) Phosphorylase b kinase gamma catalytic chain, testis/liver| isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase gamma subunit 2) Length = 406 Score = 46.6 bits (109), Expect = 4e-05 Identities = 42/133 (31%), Positives = 59/133 (44%), Gaps = 18/133 (13%) Frame = +2 Query: 62 VVEEGSFRKEAESLGRVK---HRNLTVLRGYYAGPPPDVRL-----------LVYDYMPN 199 ++E + R E L V+ R + +LR AG P + L LV+D M Sbjct: 54 IMEVSAERLSLEQLEEVRDATRREMHILR-QVAGHPHIITLIDSYESSSFMFLVFDLMRK 112 Query: 200 GNLATLLQEASHQDGHILNWPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEP 379 G L L E MR L+ + FLH + ++H D+KP+NIL D + + Sbjct: 113 GELFDYLTEKVALSEKETRSIMRSLL-----EAVNFLHVNNIVHRDLKPENILLDDNMQI 167 Query: 380 HLSDFG----LEP 406 LSDFG LEP Sbjct: 168 RLSDFGFSCHLEP 180
>WEE1A_XENLA (P47817) Wee1-like protein kinase (EC 2.7.10.2)| Length = 555 Score = 46.6 bits (109), Expect = 4e-05 Identities = 24/75 (32%), Positives = 43/75 (57%) Frame = +2 Query: 131 VLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHILNWPMRHLIALGVSRGLAFL 310 V+R Y A D ++ +Y G+L L+ + + + +L ++ ++ L VS GL ++ Sbjct: 270 VVRYYSAWAEDDHMIIQNEYCNGGSLQDLIVDNNKEGQFVLEQELKEIL-LQVSMGLKYI 328 Query: 311 HQSGVIHGDVKPQNI 355 H SG++H D+KP NI Sbjct: 329 HGSGLVHMDIKPSNI 343
>RIPK5_PANTR (Q4VSN5) Receptor-interacting serine/threonine-protein kinase 5 (EC| 2.7.11.1) (Dusty protein kinase) (Dusty PK) Length = 930 Score = 46.6 bits (109), Expect = 4e-05 Identities = 35/109 (32%), Positives = 49/109 (44%), Gaps = 14/109 (12%) Frame = +2 Query: 113 KHRNLTVLRGYYAGPPPDVRLLV--------YDYMPNGNLATLL-QEASHQDGHI----- 250 KH N L +Y P LV Y+Y ++A LL E H+D + Sbjct: 690 KHWNDLALEFHYMRSLPKHERLVDLHGSVIDYNYGGGSSIAVLLIMERLHRDLYTGLKAG 749 Query: 251 LNWPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFG 397 L R IAL V G+ FLH G++H D+K +N+L D ++D G Sbjct: 750 LTLETRLQIALDVVEGIRFLHSQGLVHRDIKLKNVLLDKQNRAKITDLG 798
>OXSR1_MOUSE (Q6P9R2) Serine/threonine-protein kinase OSR1 (EC 2.7.11.1)| (Oxidative stress-responsive 1 protein) Length = 527 Score = 46.6 bits (109), Expect = 4e-05 Identities = 33/110 (30%), Positives = 54/110 (49%), Gaps = 5/110 (4%) Frame = +2 Query: 86 KEAESLGRVKHRNLTVLRGYYAG-PPPDVRLLVYDYMPNGNLATLLQ----EASHQDGHI 250 KE +++ + H N+ YY D LV + G++ +++ + H+ G + Sbjct: 62 KEIQAMSQCHHPNIV---SYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSG-V 117 Query: 251 LNWPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGL 400 L+ P I V GL +LH++G IH DVK NIL D ++DFG+ Sbjct: 118 LDEPTIATILREVLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGV 167
>STK38_MOUSE (Q91VJ4) Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1| protein kinase) (Nuclear Dbf2-related kinase 1) Length = 465 Score = 46.6 bits (109), Expect = 4e-05 Identities = 31/109 (28%), Positives = 53/109 (48%) Frame = +2 Query: 74 GSFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHIL 253 G R E + L V+ +L V++ +Y+ L+ +++P G++ TLL + Sbjct: 132 GHIRAERDIL--VEADSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEET 189 Query: 254 NWPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGL 400 + + + + +HQ G IH D+KP N+L D+ LSDFGL Sbjct: 190 QFYIAETVL-----AIDSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGL 233
>STK38_HUMAN (Q15208) Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1| protein kinase) (Nuclear Dbf2-related kinase 1) Length = 465 Score = 46.6 bits (109), Expect = 4e-05 Identities = 31/109 (28%), Positives = 53/109 (48%) Frame = +2 Query: 74 GSFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHIL 253 G R E + L V+ +L V++ +Y+ L+ +++P G++ TLL + Sbjct: 132 GHIRAERDIL--VEADSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEET 189 Query: 254 NWPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGL 400 + + + + +HQ G IH D+KP N+L D+ LSDFGL Sbjct: 190 QFYIAETVL-----AIDSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGL 233
>RIPK5_RAT (Q6XUX2) Receptor-interacting serine/threonine-protein kinase 5 (EC| 2.7.11.1) (Dusty protein kinase) (Dusty PK) Length = 927 Score = 46.6 bits (109), Expect = 4e-05 Identities = 35/109 (32%), Positives = 50/109 (45%), Gaps = 14/109 (12%) Frame = +2 Query: 113 KHRNLTVLRGYYAGPPPDVRLLV--------YDYMPNGNLATLL-QEASHQDGHI----- 250 KH N L +Y P LV Y+Y ++A LL E H+D + Sbjct: 687 KHWNDLALEFHYMRSLPKHERLVDLHGSVIDYNYGGGSSVAVLLIMERLHRDLYTGLKAG 746 Query: 251 LNWPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFG 397 L+ R IAL V G+ FLH G++H D+K +N+L D ++D G Sbjct: 747 LSLETRLQIALDVVEGIRFLHSQGLVHRDIKLKNVLLDKQNRAKITDLG 795
>KOIA_SCHPO (Q9Y7J6) Putative serine/threonine-protein kinase C1778.10c (EC| 2.7.11.1) Length = 550 Score = 46.6 bits (109), Expect = 4e-05 Identities = 21/73 (28%), Positives = 40/73 (54%) Frame = +2 Query: 179 VYDYMPNGNLATLLQEASHQDGHILNWPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNIL 358 V + PNG L +++ D + + + +++ + ++H G+IH D+KP+NIL Sbjct: 131 VLELAPNGELLQYIKKYRFLDENCVRFYAAEILS-----SIEYMHSCGIIHRDLKPENIL 185 Query: 359 FDADFEPHLSDFG 397 FD + ++DFG Sbjct: 186 FDGNMHVKITDFG 198
>RIPK5_CANFA (Q4VSN4) Receptor-interacting serine/threonine-protein kinase 5 (EC| 2.7.11.1) (Dusty protein kinase) (Dusty PK) Length = 931 Score = 46.6 bits (109), Expect = 4e-05 Identities = 35/109 (32%), Positives = 49/109 (44%), Gaps = 14/109 (12%) Frame = +2 Query: 113 KHRNLTVLRGYYAGPPPDVRLLV--------YDYMPNGNLATLL-QEASHQDGHI----- 250 KH N L +Y P LV Y+Y ++A LL E H+D + Sbjct: 691 KHWNDLALEFHYMRSLPKHERLVDLHGSVIDYNYGGGSSIAVLLIMERLHRDLYTGLKAG 750 Query: 251 LNWPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFG 397 L R IAL V G+ FLH G++H D+K +N+L D ++D G Sbjct: 751 LTLETRLQIALDVVEGIRFLHSQGLVHRDIKLKNVLLDKQNRAKITDLG 799
>HUNK_PANTR (Q68UT7) Hormonally up-regulated neu tumor-associated kinase (EC| 2.7.11.1) Length = 714 Score = 46.6 bits (109), Expect = 4e-05 Identities = 34/115 (29%), Positives = 52/115 (45%), Gaps = 7/115 (6%) Frame = +2 Query: 77 SFRKEAESLGRVKHRNLTVL-------RGYYAGPPPDVRLLVYDYMPNGNLATLLQEASH 235 + R+E + ++H N+T L YY LV + P GNL + E Sbjct: 107 NLRREGQIQQMIRHPNITQLLDILETENSYY---------LVMELCPGGNLMHKIYEKKR 157 Query: 236 QDGHILNWPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGL 400 + +R LI+ + LH++GV+H D+K +N+L D D L DFGL Sbjct: 158 LEESEARRYIRQLIS-----AVEHLHRAGVVHRDLKIENLLLDEDNNIKLIDFGL 207
>HUNK_HUMAN (P57058) Hormonally up-regulated neu tumor-associated kinase (EC| 2.7.11.1) (Serine/threonine-protein kinase MAK-V) (B19) Length = 714 Score = 46.6 bits (109), Expect = 4e-05 Identities = 34/115 (29%), Positives = 52/115 (45%), Gaps = 7/115 (6%) Frame = +2 Query: 77 SFRKEAESLGRVKHRNLTVL-------RGYYAGPPPDVRLLVYDYMPNGNLATLLQEASH 235 + R+E + ++H N+T L YY LV + P GNL + E Sbjct: 107 NLRREGQIQQMIRHPNITQLLDILETENSYY---------LVMELCPGGNLMHKIYEKKR 157 Query: 236 QDGHILNWPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGL 400 + +R LI+ + LH++GV+H D+K +N+L D D L DFGL Sbjct: 158 LEESEARRYIRQLIS-----AVEHLHRAGVVHRDLKIENLLLDEDNNIKLIDFGL 207
>MK14C_DROME (P83100) Putative mitogen-activated protein kinase 14C (EC| 2.7.11.24) (MAP kinase p38c) Length = 356 Score = 46.6 bits (109), Expect = 4e-05 Identities = 31/117 (26%), Positives = 57/117 (48%), Gaps = 4/117 (3%) Frame = +2 Query: 71 EGSFRKEAESLGRVKHRNLTVLRGYYAGPPPDV----RLLVYDYMPNGNLATLLQEASHQ 238 +G++R E L + HRN+ L + P ++ ++ + ++ + +L + Sbjct: 62 KGTYR-EIRLLKHMNHRNVISLLNVFHPPAHNMMEFQQVYLVTHLMDADLHRYSRSKRMS 120 Query: 239 DGHILNWPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGLEPM 409 D I +I + RGL ++H +GV+H D+KP NI + + E + DFGL M Sbjct: 121 DQEI------RIILYQILRGLKYIHSAGVVHRDLKPCNIAVNGNSEVRILDFGLSRM 171
>SRC_RSVSE (P63185) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 46.6 bits (109), Expect = 4e-05 Identities = 29/112 (25%), Positives = 58/112 (51%) Frame = +2 Query: 77 SFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHILN 256 +F +EA+ + +++H+ L L YA + +V +YM G+L L+ + G L Sbjct: 305 AFLQEAQVMKKLRHKKLVQL---YAVVSEEPIYIVIEYMSKGSLLDFLKG---EMGKYLR 358 Query: 257 WPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGLEPMV 412 P +A ++ G+A++ + +H D++ NIL + ++DFGL ++ Sbjct: 359 LPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLI 410
>EPA4A_BRARE (O13148) Ephrin type-A receptor 4a (EC 2.7.10.1) (Tyrosine-protein| kinase receptor ZEK2) (EPH-like kinase 2) (Fragment) Length = 292 Score = 46.2 bits (108), Expect = 5e-05 Identities = 29/107 (27%), Positives = 54/107 (50%) Frame = +2 Query: 80 FRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHILNW 259 F EA +G+ H N+ L G P +++ +YM NG+L L++ DG Sbjct: 41 FLSEASIMGQFDHPNIIRLEGVVTKCKPV--MIITEYMENGSLDAFLRK---NDGRFTVI 95 Query: 260 PMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGL 400 + ++ G++ G+ +L +H D+ +NIL +++ +SDFG+ Sbjct: 96 QLVGILR-GIASGMKYLSDMSYVHRDLAARNILVNSNLVCKVSDFGM 141
>KBN8_YEAST (P38070) Probable serine/threonine-protein kinase YBR028C (EC| 2.7.11.1) Length = 525 Score = 46.2 bits (108), Expect = 5e-05 Identities = 32/104 (30%), Positives = 50/104 (48%) Frame = +2 Query: 89 EAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHILNWPMR 268 E L ++H N+ L +Y+ L+ Y+P G L L+E D +++ Sbjct: 202 ERSILSEIEHPNIVKL--FYSFHDNSKLYLLLQYIPGGELFYHLKEHGTLDETTVSF--- 256 Query: 269 HLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGL 400 A +S L FLH GV++ D+KP+N L + L+DFGL Sbjct: 257 --YAAEISCALRFLHTKGVVYRDLKPENCLLNQRGHLVLTDFGL 298
>GSK3_SCHPO (Q10452) Protein kinase gsk3 (EC 2.7.11.1) (Protein kinaae skp1)| Length = 387 Score = 46.2 bits (108), Expect = 5e-05 Identities = 39/126 (30%), Positives = 64/126 (50%), Gaps = 8/126 (6%) Frame = +2 Query: 62 VVEEGSFR-KEAESLGRVKHRNLTVLRGYY---AGPPPDVRL-LVYDYMPNGNLATLLQE 226 V+++ F+ +E + + +KH N+ L YY +V L LV ++MP T+ + Sbjct: 63 VLQDKRFKNRELQIMRIMKHPNIVDLIAYYYTTGDNSDEVYLNLVLEFMPE----TIYRA 118 Query: 227 ASHQDGHILNWPMRH--LIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFE-PHLSDFG 397 + L+ PM L + R LA++H SG+ H D+KPQN+L D + L DFG Sbjct: 119 SRLYTRQKLSMPMLEVKLYIYQLLRSLAYIHASGICHRDIKPQNLLLDPENGILKLCDFG 178 Query: 398 LEPMVV 415 ++V Sbjct: 179 SAKILV 184
>EPB1A_XENLA (Q91571) Ephrin type-B receptor 1-A precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor XEK) Length = 985 Score = 46.2 bits (108), Expect = 5e-05 Identities = 29/109 (26%), Positives = 56/109 (51%), Gaps = 2/109 (1%) Frame = +2 Query: 80 FRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHILNW 259 F EA +G+ H N+ L G P +++ ++M NG L + L++ Q + Sbjct: 666 FLSEASIMGQFDHPNIIRLEGVVTKSRPV--MIITEFMENGALDSFLRQNDGQ------F 717 Query: 260 PMRHLIAL--GVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGL 400 + L+ + G++ G+ +L + +H D+ +NIL +++ +SDFGL Sbjct: 718 TVIQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGL 766
>CDK2_CARAU (P43450) Cell division protein kinase 2 (EC 2.7.11.22)| Length = 298 Score = 46.2 bits (108), Expect = 5e-05 Identities = 39/141 (27%), Positives = 64/141 (45%), Gaps = 9/141 (6%) Frame = +2 Query: 5 EGTVLAILRLPSTSADGAVVVEEGSFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVY 184 EGT + + + V +++ E E + R +++L+ P V+L + Sbjct: 12 EGTYGVVYKAKNKVTGETVALKKIRLDTETEGVPSTAIREISLLKEL--NHPNIVKL--H 67 Query: 185 DYMPNGNLATLLQEASHQDGHI---------LNWPMRHLIALGVSRGLAFLHQSGVIHGD 337 D + N L+ E HQD ++ P+ + +GLAF H V+H D Sbjct: 68 DVIHTENKLYLVFEFLHQDLKRFMDSSTVTGISLPLVKSYLFQLLQGLAFCHSHRVLHRD 127 Query: 338 VKPQNILFDADFEPHLSDFGL 400 +KPQN+L +A E L+DFGL Sbjct: 128 LKPQNLLINAQGEIKLADFGL 148
>CDK2_BOVIN (Q5E9Y0) Cell division protein kinase 2 (EC 2.7.11.22)| Length = 298 Score = 46.2 bits (108), Expect = 5e-05 Identities = 40/141 (28%), Positives = 63/141 (44%), Gaps = 9/141 (6%) Frame = +2 Query: 5 EGTVLAILRLPSTSADGAVVVEEGSFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVY 184 EGT + + + V +++ E E + R +++L+ P V+LL Sbjct: 12 EGTYGVVYKAKNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKEL--NHPNIVKLL-- 67 Query: 185 DYMPNGNLATLLQEASHQDGHI---------LNWPMRHLIALGVSRGLAFLHQSGVIHGD 337 D + N L+ E HQD + P+ + +GLAF H V+H D Sbjct: 68 DVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRD 127 Query: 338 VKPQNILFDADFEPHLSDFGL 400 +KPQN+L +AD L+DFGL Sbjct: 128 LKPQNLLINADGSIKLADFGL 148
>VHS1_YEAST (Q03785) Serine/threonine-protein kinase VHS1 (EC 2.7.11.1) (Viable| in a HAL3 SIT4 background protein 1) Length = 461 Score = 46.2 bits (108), Expect = 5e-05 Identities = 33/130 (25%), Positives = 59/130 (45%), Gaps = 4/130 (3%) Frame = +2 Query: 23 ILRLPSTSADGAVVVEEGSFRK----EAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDY 190 ++R+PS + + E F+K + SL H + ++ + +V DY Sbjct: 81 VVRVPSIDLESIENMSEEDFKKLPHYKEISLHLRVHHHKNIVTIHEVLQSAVCTFIVMDY 140 Query: 191 MPNGNLATLLQEASHQDGHILNWPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDAD 370 P +L T + + H + N + + L + L + H+ G+ H D+KP+N+L D + Sbjct: 141 YPT-DLFTSIVDNRH---FVTNGLLVKKVFLQICSALNYCHEHGIYHCDIKPENLLLDTE 196 Query: 371 FEPHLSDFGL 400 L DFGL Sbjct: 197 DNVFLCDFGL 206
>SRC_HUMAN (P12931) Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2)| (p60-Src) (c-Src) (pp60c-src) Length = 535 Score = 46.2 bits (108), Expect = 5e-05 Identities = 29/112 (25%), Positives = 57/112 (50%) Frame = +2 Query: 77 SFRKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHILN 256 +F +EA+ + +++H L L YA + +V +YM G+L L+ + G L Sbjct: 308 AFLQEAQVMKKLRHEKLVQL---YAVVSEEPIYIVTEYMSKGSLLDFLKG---ETGKYLR 361 Query: 257 WPMRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGLEPMV 412 P +A ++ G+A++ + +H D++ NIL + ++DFGL ++ Sbjct: 362 LPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLI 413
>MELK_HUMAN (Q14680) Maternal embryonic leucine zipper kinase (EC 2.7.11.1)| (hMELK) (Protein kinase PK38) (hPK38) Length = 651 Score = 46.2 bits (108), Expect = 5e-05 Identities = 28/106 (26%), Positives = 50/106 (47%) Frame = +2 Query: 83 RKEAESLGRVKHRNLTVLRGYYAGPPPDVRLLVYDYMPNGNLATLLQEASHQDGHILNWP 262 + E E+L ++H+++ L Y+ + +V +Y P G L + Sbjct: 55 KTEIEALKNLRHQHICQL--YHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVV 112 Query: 263 MRHLIALGVSRGLAFLHQSGVIHGDVKPQNILFDADFEPHLSDFGL 400 R +++ +A++H G H D+KP+N+LFD + L DFGL Sbjct: 113 FRQIVS-----AVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGL 153 Database: uniprot_sprot.fasta Posted date: May 25, 2006 5:36 PM Number of letters in database: 80,573,946 Number of sequences in database: 219,361 Lambda K H 0.318 0.135 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 62,875,932 Number of Sequences: 219361 Number of extensions: 1194961 Number of successful extensions: 5987 Number of sequences better than 10.0: 500 Number of HSP's better than 10.0 without gapping: 5513 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 5725 length of database: 80,573,946 effective HSP length: 104 effective length of database: 57,760,402 effective search space used: 3465624120 frameshift window, decay const: 50, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)
