ナショナルバイオリソースプロジェクト
-Barley Genetic Resources Database-
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| Clone Name | bart48c05 |
|---|---|
| Clone Library Name | barley_pub |
>CDPK_DAUCA (P28582) Calcium-dependent protein kinase (EC 2.7.11.1) (CDPK)| Length = 532 Score = 82.4 bits (202), Expect = 8e-16 Identities = 55/180 (30%), Positives = 86/180 (47%), Gaps = 4/180 (2%) Frame = +2 Query: 8 KPEENH*TMSGELNRD----YXXXXXXXXXXFGVVHRCTSRSTGEAFAVKXXXXXXXXXX 175 +PE N T+ G+ D Y FG V++CT S+G+ +A K Sbjct: 63 RPESN--TILGKPFEDIRGKYTLGKELGRGQFGCVYQCTENSSGQLYACKSILKRKLVSK 120 Query: 176 XXXELAEIEPKLAQLAAAGNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPV 355 E + E ++ Q +G P +V+ V+ED H+VM+LC+G +L D R+ Sbjct: 121 NDKEDIKREIQILQ-HLSGQPNIVEFKGVFEDRQSVHLVMELCAGGELFD--RIIAQGHY 177 Query: 356 PEPVAADIVAQLAQALALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSAAWI 535 E AA I Q+ + +CH GV+HRD+KP+N +L D+ + DFG + +I Sbjct: 178 SERAAATICRQIVNVVHVCHFMGVMHRDLKPENFLLSSKDK----DAMLKATDFGLSVFI 233
>CDPK2_MAIZE (P49101) Calcium-dependent protein kinase 2 (EC 2.7.11.1) (CDPK 2)| Length = 513 Score = 77.4 bits (189), Expect = 3e-14 Identities = 47/149 (31%), Positives = 73/149 (48%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 FGV + CT ++G +A K E E ++ Q +G P +V+ YE Sbjct: 76 FGVTYLCTEIASGRQYACKSISKRKLVSKADREDIRREIQIMQ-HLSGQPNIVEFRGAYE 134 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 D S H+VM+LC+G +L D R+ E AA I + + +CH GV+HRD+KP Sbjct: 135 DKSNVHVVMELCAGGELFD--RIIAKGHYTERAAATICRAVVNVVNICHFMGVMHRDLKP 192 Query: 449 DNVVLDVDDEGENGSPRARLADFGSAAWI 535 +N +L +E + + DFG + +I Sbjct: 193 ENFLLATMEE----NAMLKATDFGLSVFI 217
>CDPK3_ORYSA (P53684) Calcium-dependent protein kinase, isoform 11 (EC 2.7.11.1)| (CDPK 11) Length = 542 Score = 76.6 bits (187), Expect = 4e-14 Identities = 46/149 (30%), Positives = 74/149 (49%), Gaps = 1/149 (0%) Frame = +2 Query: 35 SGELNRDYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLA 214 + +L Y FG + CT +TG +A K E E ++ Sbjct: 72 TADLREHYIIGRKLGQGQFGTTYLCTEINTGCEYACKTIPKRKLITKEDVEDVRREIQIM 131 Query: 215 QLAAAGNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLA 394 +G+ VV + VYED H+VM+LC+G +L D R++ E AA+++ + Sbjct: 132 H-HLSGHKNVVAIKDVYEDGQAVHIVMELCAGGELFD--RIQEKGHYSERKAAELIRIIV 188 Query: 395 QALALCHRRGVIHRDVKPDN-VVLDVDDE 478 +A+CH GV+HRD+KP+N ++LD DD+ Sbjct: 189 SIVAMCHSLGVMHRDLKPENFLLLDKDDD 217
>CSKP_MOUSE (O70589) Peripheral plasma membrane protein CASK (EC 2.7.11.1)| (Calcium/calmodulin-dependent serine protein kinase) Length = 924 Score = 75.9 bits (185), Expect = 7e-14 Identities = 49/155 (31%), Positives = 72/155 (46%), Gaps = 2/155 (1%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 F VV RC +R TG+ FAVK +++ + + +P +V++ Y Sbjct: 23 FSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHMLKHPHIVELLETYS 82 Query: 269 DDSWTHMVMDLCSGPDLLDWV--RLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDV 442 D +MV + G DL + R G E VA+ + Q+ +AL CH +IHRDV Sbjct: 83 SDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILEALRYCHDNNIIHRDV 142 Query: 443 KPDNVVLDVDDEGENGSPRARLADFGSAAWIGADG 547 KP V+L EN +P +L FG A +G G Sbjct: 143 KPHCVLL---ASKENSAP-VKLGGFGVAIQLGESG 173
>CSKP_HUMAN (O14936) Peripheral plasma membrane protein CASK (EC 2.7.11.1)| (hCASK) (Calcium/calmodulin-dependent serine protein kinase) (Lin-2 homolog) Length = 926 Score = 75.9 bits (185), Expect = 7e-14 Identities = 49/155 (31%), Positives = 72/155 (46%), Gaps = 2/155 (1%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 F VV RC +R TG+ FAVK +++ + + +P +V++ Y Sbjct: 23 FSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHMLKHPHIVELLETYS 82 Query: 269 DDSWTHMVMDLCSGPDLLDWV--RLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDV 442 D +MV + G DL + R G E VA+ + Q+ +AL CH +IHRDV Sbjct: 83 SDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILEALRYCHDNNIIHRDV 142 Query: 443 KPDNVVLDVDDEGENGSPRARLADFGSAAWIGADG 547 KP V+L EN +P +L FG A +G G Sbjct: 143 KPHCVLL---ASKENSAP-VKLGGFGVAIQLGESG 173
>CSKP_RAT (Q62915) Peripheral plasma membrane protein CASK (EC 2.7.11.1)| (Calcium/calmodulin-dependent serine protein kinase) Length = 909 Score = 75.9 bits (185), Expect = 7e-14 Identities = 49/155 (31%), Positives = 72/155 (46%), Gaps = 2/155 (1%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 F VV RC +R TG+ FAVK +++ + + +P +V++ Y Sbjct: 23 FSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHMLKHPHIVELLETYS 82 Query: 269 DDSWTHMVMDLCSGPDLLDWV--RLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDV 442 D +MV + G DL + R G E VA+ + Q+ +AL CH +IHRDV Sbjct: 83 SDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILEALRYCHDNNIIHRDV 142 Query: 443 KPDNVVLDVDDEGENGSPRARLADFGSAAWIGADG 547 KP V+L EN +P +L FG A +G G Sbjct: 143 KPHCVLL---ASKENSAP-VKLGGFGVAIQLGESG 173
>CDPK2_ORYSA (P53683) Calcium-dependent protein kinase, isoform 2 (EC 2.7.11.1)| (CDPK 2) Length = 533 Score = 75.5 bits (184), Expect = 1e-13 Identities = 46/149 (30%), Positives = 73/149 (48%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 FGV + CT ++G+ +A K E E ++ Q +G +V+ YE Sbjct: 96 FGVTYLCTEIASGKQYACKSISKRKLVSKADKEDIRREIQIMQ-HLSGQQNIVEFRGAYE 154 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 D S H+VM+LC+G +L D R+ E AA I + + +CH GV+HRD+KP Sbjct: 155 DKSNVHVVMELCAGGELFD--RIIAKGHYSERAAATICRAVVNVVNICHFMGVMHRDLKP 212 Query: 449 DNVVLDVDDEGENGSPRARLADFGSAAWI 535 +N +L +E + + DFG + +I Sbjct: 213 ENFLLATKEE----NAMLKATDFGLSVFI 237
>PKH3_ASHGO (Q753D9) Serine/threonine-protein kinase PKH3 (EC 2.7.11.1)| Length = 726 Score = 73.9 bits (180), Expect = 3e-13 Identities = 50/156 (32%), Positives = 75/156 (48%), Gaps = 2/156 (1%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPK-LAQLAAAGNPGVVQVHAVY 265 + V+R RS+ +A+K + IE L L A +PG+++++ + Sbjct: 21 YSTVYRVVERSSQHQYAIKICSKRHIIGENKVKYVTIEKNTLNLLGQANHPGIIKLYYTF 80 Query: 266 EDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVK 445 D + VMDL G +LL LRR E A + QL + H GVIHRD+K Sbjct: 81 HDQENLYFVMDLAPGGELLQL--LRRQRVFSEAWARHYMCQLVDTVEYIHSMGVIHRDLK 138 Query: 446 PDNVVLDVDDEGENGSPRARLADFGSAAWIG-ADGG 550 P+NV+LD + R +ADFG+A +G +D G Sbjct: 139 PENVLLDKEG-------RLMIADFGAAYTVGQSDAG 167
>RAD53_YEAST (P22216) Serine/threonine-protein kinase RAD53 (EC 2.7.11.1)| (Serine-protein kinase 1) Length = 821 Score = 73.2 bits (178), Expect = 5e-13 Identities = 46/146 (31%), Positives = 69/146 (47%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 F V + R+TG+ FAVK E+E L +P +V++ YE Sbjct: 209 FATVKKAIERTTGKTFAVKIISKRKVIGNMDGVTRELEV----LQKLNHPRIVRLKGFYE 264 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 D +MVM+ SG DL+D+V V E +I Q+ A+ H G+ HRD+KP Sbjct: 265 DTESYYMVMEFVSGGDLMDFVAAH--GAVGEDAGREISRQILTAIKYIHSMGISHRDLKP 322 Query: 449 DNVVLDVDDEGENGSPRARLADFGSA 526 DN++++ DD ++ DFG A Sbjct: 323 DNILIEQDD-----PVLVKITDFGLA 343
>KS6A2_MOUSE (Q9WUT3) Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1)| (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (Protein-tyrosine kinase Mpk-9) (MAP kinase-activated protein kinase 1c) (M Length = 733 Score = 72.8 bits (177), Expect = 6e-13 Identities = 45/155 (29%), Positives = 78/155 (50%), Gaps = 1/155 (0%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 + V RC ++T +AVK E+ L +P ++ + VY+ Sbjct: 426 YSVCKRCVHKATDAEYAVKIIDKSKRDPSEEIEIL--------LRYGQHPNIITLKDVYD 477 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 D + ++VM+L G +LLD R+ R E A+D++ +A+ + H +GV+HRD+KP Sbjct: 478 DGKYVYLVMELMRGGELLD--RILRQRCFSEREASDVLYTIARTMDYLHSQGVVHRDLKP 535 Query: 449 DNVVLDVDDEGENGSPRA-RLADFGSAAWIGADGG 550 N++ E+G+P + R+ DFG A + A+ G Sbjct: 536 SNILY----MDESGNPESIRICDFGFAKQLRAENG 566 Score = 54.7 bits (130), Expect = 2e-07 Identities = 38/142 (26%), Positives = 71/142 (50%) Frame = +2 Query: 95 VVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYEDD 274 +V + T G+ +A+K +++E + LA +P +V++H ++ + Sbjct: 75 LVRKVTGSDAGQLYAMKVLKKATLKVRDRVR-SKMERDI--LAEVNHPFIVKLHYAFQTE 131 Query: 275 SWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKPDN 454 ++++D G DL + RL + E +A+LA AL H G+I+RD+KP+N Sbjct: 132 GKLYLILDFLRGGDL--FTRLSKEVMFTEEDVKFYLAELALALDHLHGLGIIYRDLKPEN 189 Query: 455 VVLDVDDEGENGSPRARLADFG 520 ++L D+EG ++ DFG Sbjct: 190 ILL--DEEG-----HIKITDFG 204
>CDPK_SOYBN (P28583) Calcium-dependent protein kinase SK5 (EC 2.7.11.1) (CDPK)| Length = 508 Score = 72.8 bits (177), Expect = 6e-13 Identities = 44/144 (30%), Positives = 69/144 (47%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 FG CT R++G FA K E E ++ + + VV++ YE Sbjct: 45 FGTTFECTRRASGGKFACKSIPKRKLLCKEDYEDVWREIQIMHHLSE-HANVVRIEGTYE 103 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 D + H+VM+LC G +L D R+ + E AA ++ + + + CH GV+HRD+KP Sbjct: 104 DSTAVHLVMELCEGGELFD--RIVQKGHYSERQAARLIKTIVEVVEACHSLGVMHRDLKP 161 Query: 449 DNVVLDVDDEGENGSPRARLADFG 520 +N + D DE + + DFG Sbjct: 162 ENFLFDTIDE----DAKLKATDFG 181
>CRK_DAUCA (P53681) CDPK-related protein kinase (EC 2.7.11.1) (PK421)| Length = 602 Score = 72.8 bits (177), Expect = 6e-13 Identities = 44/140 (31%), Positives = 71/140 (50%) Frame = +2 Query: 125 GEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYEDDSWTHMVMDLC 304 G+ AVK E E K+ + A G+ +VQ + +ED + ++VM+LC Sbjct: 174 GQDVAVKVIPKAKMTTAIAIEDVRREVKILR-ALTGHNNLVQFYDAFEDHTNVYVVMELC 232 Query: 305 SGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKPDNVVLDVDDEGE 484 G +LLD + L RG E A ++ Q+ +A CH +GV+HRD+KP+N + DE Sbjct: 233 EGGELLDRI-LSRGGKYTEDDAKAVMIQILNVVAFCHLQGVVHRDLKPENFLFKSKDE-- 289 Query: 485 NGSPRARLADFGSAAWIGAD 544 + + DFG + ++ D Sbjct: 290 --DSQLKAIDFGLSDYVKPD 307
>ROCK1_RAT (Q63644) Rho-associated protein kinase 1 (EC 2.7.11.1)| (Rho-associated, coiled-coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK) (p150 RhoA-binding kinase ROK beta) (Liver regeneration-related protein LRRG199) Length = 1369 Score = 72.4 bits (176), Expect = 8e-13 Identities = 53/165 (32%), Positives = 74/165 (44%) Frame = +2 Query: 53 DYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAG 232 DY FG V +ST + +A+K E + +A A Sbjct: 75 DYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDI--MAFAN 132 Query: 233 NPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALC 412 +P VVQ+ ++DD + +MVM+ G DL V L VPE A A++ AL Sbjct: 133 SPWVVQLFYAFQDDRYLYMVMEYMPGGDL---VNLMSNYDVPEKWARFYTAEVVLALDAI 189 Query: 413 HRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSAAWIGADG 547 H G IHRDVKPDN++LD S +LADFG+ + +G Sbjct: 190 HSMGFIHRDVKPDNMLLD-------KSGHLKLADFGTCMKMNKEG 227
>ROCK1_RABIT (O77819) Rho-associated protein kinase 1 (EC 2.7.11.1)| (Rho-associated, coiled-coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK) (cAMP-dependent protein kinase ROCK-I) (CePKA) (Corneal epithelial Rho-associated-Ser/Thr kinase 1) (HEB Length = 1354 Score = 72.4 bits (176), Expect = 8e-13 Identities = 53/165 (32%), Positives = 74/165 (44%) Frame = +2 Query: 53 DYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAG 232 DY FG V +ST + +A+K E + +A A Sbjct: 75 DYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDI--MAFAN 132 Query: 233 NPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALC 412 +P VVQ+ ++DD + +MVM+ G DL V L VPE A A++ AL Sbjct: 133 SPWVVQLFYAFQDDRYLYMVMEYMPGGDL---VNLMSNYDVPEKWARFYTAEVVLALDAI 189 Query: 413 HRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSAAWIGADG 547 H G IHRDVKPDN++LD S +LADFG+ + +G Sbjct: 190 HSMGFIHRDVKPDNMLLD-------KSGHLKLADFGTCMKMNKEG 227
>ROCK1_MOUSE (P70335) Rho-associated protein kinase 1 (EC 2.7.11.1)| (Rho-associated, coiled-coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK) Length = 1354 Score = 72.4 bits (176), Expect = 8e-13 Identities = 53/165 (32%), Positives = 74/165 (44%) Frame = +2 Query: 53 DYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAG 232 DY FG V +ST + +A+K E + +A A Sbjct: 75 DYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDI--MAFAN 132 Query: 233 NPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALC 412 +P VVQ+ ++DD + +MVM+ G DL V L VPE A A++ AL Sbjct: 133 SPWVVQLFYAFQDDRYLYMVMEYMPGGDL---VNLMSNYDVPEKWARFYTAEVVLALDAI 189 Query: 413 HRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSAAWIGADG 547 H G IHRDVKPDN++LD S +LADFG+ + +G Sbjct: 190 HSMGFIHRDVKPDNMLLD-------KSGHLKLADFGTCMKMNKEG 227
>ROCK1_HUMAN (Q13464) Rho-associated protein kinase 1 (EC 2.7.11.1)| (Rho-associated, coiled-coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK) (NY-REN-35 antigen) Length = 1354 Score = 72.4 bits (176), Expect = 8e-13 Identities = 53/165 (32%), Positives = 74/165 (44%) Frame = +2 Query: 53 DYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAG 232 DY FG V +ST + +A+K E + +A A Sbjct: 75 DYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDI--MAFAN 132 Query: 233 NPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALC 412 +P VVQ+ ++DD + +MVM+ G DL V L VPE A A++ AL Sbjct: 133 SPWVVQLFYAFQDDRYLYMVMEYMPGGDL---VNLMSNYDVPEKWARFYTAEVVLALDAI 189 Query: 413 HRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSAAWIGADG 547 H G IHRDVKPDN++LD S +LADFG+ + +G Sbjct: 190 HSMGFIHRDVKPDNMLLD-------KSGHLKLADFGTCMKMNKEG 227
>KCC2A_DROME (Q00168) Calcium/calmodulin-dependent protein kinase type II alpha| chain (EC 2.7.11.17) (CaM-kinase II alpha chain) Length = 530 Score = 72.0 bits (175), Expect = 1e-12 Identities = 47/161 (29%), Positives = 82/161 (50%), Gaps = 8/161 (4%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 F +V RC +STG FA K +L E E ++ + +P +V++H + Sbjct: 25 FSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKL-EREARICR--KLHHPNIVRLHDSIQ 81 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 ++++ ++V DL +G +L + + R E A+ + Q+ +++ CH+ GV+HRD+KP Sbjct: 82 EENYHYLVFDLVTGGELFEDIVAREF--YSEADASHCIQQILESVNHCHQNGVVHRDLKP 139 Query: 449 DNVVLDVDDEGENGSPRARLADFGSA--------AWIGADG 547 +N++L +G +LADFG A AW G G Sbjct: 140 ENLLLASKAKG----AAVKLADFGLAIEVQGDHQAWFGFAG 176
>KS6A2_HUMAN (Q15349) Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1)| (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (MAP kinase-activated protein kinase 1c) (MAPKAPK1C) Length = 733 Score = 72.0 bits (175), Expect = 1e-12 Identities = 45/155 (29%), Positives = 76/155 (49%), Gaps = 1/155 (0%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 + V RC ++T +AVK E+ L +P ++ + VY+ Sbjct: 426 YSVCKRCVHKATDTEYAVKIIDKSKRDPSEEIEIL--------LRYGQHPNIITLKDVYD 477 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 D + ++VM+L G +LLD R+ R E A+D++ + + + H +GV+HRD+KP Sbjct: 478 DGKFVYLVMELMRGGELLD--RILRQRYFSEREASDVLCTITKTMDYLHSQGVVHRDLKP 535 Query: 449 DNVVLDVDDEGENGSPRA-RLADFGSAAWIGADGG 550 N++ E+GSP + R+ DFG A + A G Sbjct: 536 SNILY----RDESGSPESIRVCDFGFAKQLRAGNG 566 Score = 54.7 bits (130), Expect = 2e-07 Identities = 32/101 (31%), Positives = 56/101 (55%) Frame = +2 Query: 218 LAAAGNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQ 397 LA +P +V++H ++ + ++++D G DL + RL + E +A+LA Sbjct: 113 LAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDL--FTRLSKEVMFTEEDVKFYLAELAL 170 Query: 398 ALALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFG 520 AL H G+I+RD+KP+N++L D+EG ++ DFG Sbjct: 171 ALDHLHSLGIIYRDLKPENILL--DEEG-----HIKITDFG 204
>CDPK1_ORYSA (P53682) Calcium-dependent protein kinase, isoform 1 (EC 2.7.11.1)| (CDPK 1) Length = 534 Score = 71.6 bits (174), Expect = 1e-12 Identities = 41/131 (31%), Positives = 67/131 (51%), Gaps = 1/131 (0%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 FG + CT STG +A K E E ++ +G +V + YE Sbjct: 84 FGKTYLCTEISTGCQYACKTILKSNLRCVSDIEDVRREIQIMH-HLSGQKNIVTIKDTYE 142 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 D+ H+VM+LC+G +L ++++ E AA+++ + + CH GV+HRD+KP Sbjct: 143 DEQAVHIVMELCAGGELFS--KIQKRGHYSERKAAELIKIIVGIIETCHSHGVMHRDLKP 200 Query: 449 DN-VVLDVDDE 478 +N ++LD DDE Sbjct: 201 ENFLLLDADDE 211
>KS6A4_HUMAN (O75676) Ribosomal protein S6 kinase alpha-4 (EC 2.7.11.1) (Nuclear| mitogen-and stress-activated protein kinase 2) (90 kDa ribosomal protein S6 kinase 4) (Ribosomal protein kinase B) (RSKB) Length = 772 Score = 70.1 bits (170), Expect = 4e-12 Identities = 48/147 (32%), Positives = 75/147 (51%), Gaps = 1/147 (0%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 F V RC R +G+ FAVK E+A + +L Q +P VV +H V+ Sbjct: 422 FSVCRRCRQRQSGQEFAVKILSRRLEANTQR-EVAAL--RLCQ----SHPNVVNLHEVHH 474 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRR-GVIHRDVK 445 D T++V++L G +LL+ +R +R E A+ I+ L A++ H GV+HRD+K Sbjct: 475 DQLHTYLVLELLRGGELLEHIRKKRH--FSESEASQILRSLVSAVSFMHEEAGVVHRDLK 532 Query: 446 PDNVVLDVDDEGENGSPRARLADFGSA 526 P+N++ D G ++ DFG A Sbjct: 533 PENILYADDTPG----APVKIIDFGFA 555 Score = 41.2 bits (95), Expect = 0.002 Identities = 22/77 (28%), Positives = 42/77 (54%) Frame = +2 Query: 236 PGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCH 415 P +V +H ++ D+ H+++D SG ++ + L + E ++ AL H Sbjct: 96 PFLVTLHYAFQTDAKLHLILDYVSGGEM--FTHLYQRQYFKEAEVRVYGGEIVLALEHLH 153 Query: 416 RRGVIHRDVKPDNVVLD 466 + G+I+RD+K +NV+LD Sbjct: 154 KLGIIYRDLKLENVLLD 170
>MRCKG_HUMAN (Q6DT37) Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1)| (CDC42-binding protein kinase gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (Myotonic dystrophy protein kinase-like alpha) (MRCK gamma) (DMPK-like gamma Length = 1551 Score = 70.1 bits (170), Expect = 4e-12 Identities = 51/153 (33%), Positives = 75/153 (49%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 FG V R TG+ FA+K E A + L + V +H ++ Sbjct: 82 FGEVTVVRQRDTGQIFAMKMLHKWEMLKRA--ETACFREERDVLVKGDSRWVTTLHYAFQ 139 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 D+ + ++VMD +G DLL + R +P +A +A++ A+ H+ G +HRDVKP Sbjct: 140 DEEYLYLVMDYYAGGDLLTLLS-RFEDRLPPELAQFYLAEMVLAIHSLHQLGYVHRDVKP 198 Query: 449 DNVVLDVDDEGENGSPRARLADFGSAAWIGADG 547 DNV+LDV NG RLADFGS + +G Sbjct: 199 DNVLLDV-----NG--HIRLADFGSCLRLNTNG 224
>KCC2D_HUMAN (Q13557) Calcium/calmodulin-dependent protein kinase type II delta| chain (EC 2.7.11.17) (CaM-kinase II delta chain) (CaM kinase II delta subunit) (CaMK-II delta subunit) Length = 499 Score = 69.7 bits (169), Expect = 5e-12 Identities = 46/161 (28%), Positives = 79/161 (49%), Gaps = 8/161 (4%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 F VV RC TG+ +A K +L E E ++ +L +P +V++H Sbjct: 25 FSVVRRCMKIPTGQGYAAKIINTKKLSARDHQKL-EREARICRLLK--HPNIVRLHDSIS 81 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 ++ + ++V DL +G +L + + R E A+ + Q+ +++ CH G++HRD+KP Sbjct: 82 EEGFHYLVFDLVTGGELFEDIVAREY--YSEADASHCIQQILESVNHCHLNGIVHRDLKP 139 Query: 449 DNVVLDVDDEGENGSPRARLADFGSA--------AWIGADG 547 +N++L +G +LADFG A AW G G Sbjct: 140 ENLLLASKSKG----AAVKLADFGLAIEVQGDQQAWFGFAG 176
>KCC2D_RAT (P15791) Calcium/calmodulin-dependent protein kinase type II delta| chain (EC 2.7.11.17) (CaM-kinase II delta chain) (CaM kinase II delta subunit) (CaMK-II delta subunit) Length = 533 Score = 69.3 bits (168), Expect = 7e-12 Identities = 46/161 (28%), Positives = 79/161 (49%), Gaps = 8/161 (4%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 F VV RC TG+ +A K +L E E ++ +L +P +V++H Sbjct: 25 FSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKL-EREARICRLLK--HPNIVRLHDSIS 81 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 ++ + ++V DL +G +L + + R E A+ + Q+ +++ CH G++HRD+KP Sbjct: 82 EEGFHYLVFDLVTGGELFEDIVAREY--YSEADASHCIQQILESVNHCHLNGIVHRDLKP 139 Query: 449 DNVVLDVDDEGENGSPRARLADFGSA--------AWIGADG 547 +N++L +G +LADFG A AW G G Sbjct: 140 ENLLLASKSKG----AAVKLADFGLAIEVQGDQQAWFGFAG 176
>KCC2B_RAT (P08413) Calcium/calmodulin-dependent protein kinase type II beta| chain (EC 2.7.11.17) (CaM-kinase II beta chain) (CaM kinase II beta subunit) (CaMK-II beta subunit) Length = 542 Score = 69.3 bits (168), Expect = 7e-12 Identities = 48/161 (29%), Positives = 78/161 (48%), Gaps = 8/161 (4%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 F VV RC TG +A K +L E E ++ +L N +V++H Sbjct: 25 FSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKL-EREARICRLLKHSN--IVRLHDSIS 81 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 ++ + ++V DL +G +L + + R E A+ + Q+ +A+ CH+ GV+HRD+KP Sbjct: 82 EEGFHYLVFDLVTGGELFEDIVAREY--YSEADASHCIQQILEAVLHCHQMGVVHRDLKP 139 Query: 449 DNVVLDVDDEGENGSPRARLADFGSA--------AWIGADG 547 +N++L +G +LADFG A AW G G Sbjct: 140 ENLLLASKCKG----AAVKLADFGLAIEVQGDQQAWFGFAG 176
>KCC2B_MOUSE (P28652) Calcium/calmodulin-dependent protein kinase type II beta| chain (EC 2.7.11.17) (CaM-kinase II beta chain) (CaM kinase II beta subunit) (CaMK-II beta subunit) Length = 542 Score = 69.3 bits (168), Expect = 7e-12 Identities = 48/161 (29%), Positives = 78/161 (48%), Gaps = 8/161 (4%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 F VV RC TG +A K +L E E ++ +L N +V++H Sbjct: 25 FSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKL-EREARICRLLKHSN--IVRLHDSIS 81 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 ++ + ++V DL +G +L + + R E A+ + Q+ +A+ CH+ GV+HRD+KP Sbjct: 82 EEGFHYLVFDLVTGGELFEDIVAREY--YSEADASHCIQQILEAVLHCHQMGVVHRDLKP 139 Query: 449 DNVVLDVDDEGENGSPRARLADFGSA--------AWIGADG 547 +N++L +G +LADFG A AW G G Sbjct: 140 ENLLLASKCKG----AAVKLADFGLAIEVQGDQQAWFGFAG 176
>KAPC_YEAST (P05986) cAMP-dependent protein kinase type 3 (EC 2.7.11.11) (PKA| 3) Length = 398 Score = 69.3 bits (168), Expect = 7e-12 Identities = 48/178 (26%), Positives = 81/178 (45%), Gaps = 1/178 (0%) Frame = +2 Query: 5 RKPEENH*TMSGELN-RDYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKXXXXXXXXXXXX 181 +KP + SG+ + D+ FG VH S G +A+K Sbjct: 70 KKPMLQYRDTSGKYSLSDFQILRTLGTGSFGRVHLIRSNHNGRFYALKTLKKHTIVKLKQ 129 Query: 182 XELAEIEPKLAQLAAAGNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPE 361 E E ++ L+ +P ++++ ++D MVMD G +L LR+ P Sbjct: 130 VEHTNDERRM--LSIVSHPFIIRMWGTFQDSQQVFMVMDYIEGGELFSL--LRKSQRFPN 185 Query: 362 PVAADIVAQLAQALALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSAAWI 535 PVA A++ AL H + +I+RD+KP+N++LD +NG ++ DFG A ++ Sbjct: 186 PVAKFYAAEVCLALEYLHSKDIIYRDLKPENILLD-----KNG--HIKITDFGFAKYV 236
>KS6A5_CHICK (Q5F3L1) Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1)| Length = 789 Score = 69.3 bits (168), Expect = 7e-12 Identities = 46/146 (31%), Positives = 77/146 (52%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 F + +C + T + +AVK E+ + KL + G+P VV++H VY Sbjct: 427 FSICRKCLHKKTSQEYAVKIISKRMEANTQR-EITAL--KLCE----GHPNVVKLHEVYH 479 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 D T +VM+L G +LL+ R+++ E A+ I+ +L A++ H GV+HRD+KP Sbjct: 480 DQLHTFLVMELLKGGELLE--RIQKKQHFSETEASHIMRRLVSAVSHMHDVGVVHRDLKP 537 Query: 449 DNVVLDVDDEGENGSPRARLADFGSA 526 +N++ DE +N ++ DFG A Sbjct: 538 ENLLF--TDETDNS--EIKIIDFGFA 559 Score = 45.8 bits (107), Expect = 8e-05 Identities = 22/80 (27%), Positives = 45/80 (56%) Frame = +2 Query: 233 NPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALC 412 +P +V +H ++ D+ H+++D +G +L + L + E + ++ AL Sbjct: 101 SPFLVTLHYAFQTDTKLHLILDYINGGEL--FTHLSQRERFSENEVQIYIGEIVLALEHL 158 Query: 413 HRRGVIHRDVKPDNVVLDVD 472 H+ G+I+RD+K +N++LD D Sbjct: 159 HKLGIIYRDIKLENILLDSD 178
>KCC2B_HUMAN (Q13554) Calcium/calmodulin-dependent protein kinase type II beta| chain (EC 2.7.11.17) (CaM-kinase II beta chain) (CaM kinase II beta subunit) (CaMK-II beta subunit) Length = 664 Score = 69.3 bits (168), Expect = 7e-12 Identities = 48/161 (29%), Positives = 78/161 (48%), Gaps = 8/161 (4%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 F VV RC TG +A K +L E E ++ +L N +V++H Sbjct: 25 FSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKL-EREARICRLLKHSN--IVRLHDSIS 81 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 ++ + ++V DL +G +L + + R E A+ + Q+ +A+ CH+ GV+HRD+KP Sbjct: 82 EEGFHYLVFDLVTGGELFEDIVAREY--YSEADASHCIQQILEAVLHCHQMGVVHRDLKP 139 Query: 449 DNVVLDVDDEGENGSPRARLADFGSA--------AWIGADG 547 +N++L +G +LADFG A AW G G Sbjct: 140 ENLLLASKCKG----AAVKLADFGLAIEVQGDQQAWFGFAG 176
>KCCS_MALDO (Q07250) Calcium/calmodulin-dependent serine/threonine-protein| kinase (EC 2.7.11.17) Length = 415 Score = 69.3 bits (168), Expect = 7e-12 Identities = 32/74 (43%), Positives = 50/74 (67%) Frame = +2 Query: 233 NPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALC 412 +P V+ ++ VYED++ H+V++LCSG +L D R+ + E AA +V Q+AQ LA Sbjct: 107 HPNVIDLYDVYEDENGVHLVLELCSGGELFD--RIVKQERYSEVGAAAVVRQIAQGLAAL 164 Query: 413 HRRGVIHRDVKPDN 454 HR ++HRD+KP+N Sbjct: 165 HRSNIVHRDLKPEN 178
>ROCK2_BOVIN (Q28021) Rho-associated protein kinase 2 (EC 2.7.11.1)| (Rho-associated, coiled-coil-containing protein kinase 2) (p164 ROCK-2) Length = 1388 Score = 68.9 bits (167), Expect = 9e-12 Identities = 50/157 (31%), Positives = 74/157 (47%) Frame = +2 Query: 53 DYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAG 232 DY FG V +++ + +A+K E + +A A Sbjct: 91 DYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDI--MAFAN 148 Query: 233 NPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALC 412 +P VVQ+ ++DD + +MVM+ G DL V L VPE A A++ AL Sbjct: 149 SPWVVQLFCAFQDDKYLYMVMEYMPGGDL---VNLMSNYDVPEKWAKFYTAEVVLALDAI 205 Query: 413 HRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGS 523 H G+IHRDVKPDN++LD ++G +LADFG+ Sbjct: 206 HSMGLIHRDVKPDNMLLD-----KHG--HLKLADFGT 235
>CDPK2_PLAFK (O15865) Calcium-dependent protein kinase 2 (EC 2.7.11.1) (PfCDPK2)| Length = 512 Score = 68.9 bits (167), Expect = 9e-12 Identities = 45/169 (26%), Positives = 83/169 (49%), Gaps = 1/169 (0%) Frame = +2 Query: 35 SGELNRDYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXX-ELAEIEPKL 211 SG+L Y +G V++ + T + +A+K + EI KL Sbjct: 64 SGKLEDKYIIDEKLGQGTYGCVYKGIDKVTNQLYAIKEEKKDRLKNINRFFQEIEIMKKL 123 Query: 212 AQLAAAGNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQL 391 +P +V+++ YE+D++ +++M+LCSG +L D + + G+ E AA I+ Q+ Sbjct: 124 ------DHPNIVKLYETYENDNYIYLIMELCSGRELFDSI-IENGS-FTEKNAATIMKQI 175 Query: 392 AQALALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSAAWIG 538 A+ H ++HRD+KP+N + + EN ++ DFG + +G Sbjct: 176 FSAIFYLHSLNIVHRDLKPENFLF----QSENKDSLLKIIDFGLSKNLG 220
>CDPK2_PLAF7 (Q8ICR0) Calcium-dependent protein kinase 2 (EC 2.7.11.1) (PfCDPK2)| Length = 508 Score = 68.9 bits (167), Expect = 9e-12 Identities = 45/169 (26%), Positives = 83/169 (49%), Gaps = 1/169 (0%) Frame = +2 Query: 35 SGELNRDYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXX-ELAEIEPKL 211 SG+L Y +G V++ + T + +A+K + EI KL Sbjct: 64 SGKLEDKYIIDEKLGQGTYGCVYKGIDKVTNQLYAIKEEKKDRLKNINRFFQEIEIMKKL 123 Query: 212 AQLAAAGNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQL 391 +P +V+++ YE+D++ +++M+LCSG +L D + + G+ E AA I+ Q+ Sbjct: 124 ------DHPNIVKLYETYENDNYIYLIMELCSGRELFDSI-IENGS-FTEKNAATIMKQI 175 Query: 392 AQALALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSAAWIG 538 A+ H ++HRD+KP+N + + EN ++ DFG + +G Sbjct: 176 FSAIFYLHSLNIVHRDLKPENFLF----QSENKDSLLKIIDFGLSKNLG 220
>CDPK1_ARATH (Q06850) Calcium-dependent protein kinase, isoform AK1 (EC| 2.7.11.1) (CDPK) Length = 610 Score = 68.9 bits (167), Expect = 9e-12 Identities = 38/122 (31%), Positives = 59/122 (48%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 FG C ++TG+ FA K E E ++ AG+P V+ + YE Sbjct: 161 FGTTFLCVEKTTGKEFACKSIAKRKLLTDEDVEDVRREIQIMH-HLAGHPNVISIKGAYE 219 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 D H+VM+ C+G +L D R+ + E AA++ + + CH GV+HRD+KP Sbjct: 220 DVVAVHLVMECCAGGELFD--RIIQRGHYTERKAAELTRTIVGVVEACHSLGVMHRDLKP 277 Query: 449 DN 454 +N Sbjct: 278 EN 279
>KS6A5_PONPY (Q5R4K3) Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1)| Length = 802 Score = 68.6 bits (166), Expect = 1e-11 Identities = 42/147 (28%), Positives = 76/147 (51%), Gaps = 1/147 (0%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAA-GNPGVVQVHAVY 265 F + +C + + +AFAVK A + ++ L G+P +V++H V+ Sbjct: 437 FSICRKCVHKKSNQAFAVKIISKRME--------ANTQKEITALKLCEGHPNIVKLHEVF 488 Query: 266 EDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVK 445 D T +VM+L +G +L + R+++ E A+ I+ +L A++ H GV+HRD+K Sbjct: 489 HDQLHTFLVMELLNGGELFE--RIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHRDLK 546 Query: 446 PDNVVLDVDDEGENGSPRARLADFGSA 526 P+N++ EN + ++ DFG A Sbjct: 547 PENLLF----TDENDNLEIKIIDFGFA 569 Score = 45.8 bits (107), Expect = 8e-05 Identities = 36/151 (23%), Positives = 69/151 (45%), Gaps = 1/151 (0%) Frame = +2 Query: 95 VVHRCTSRSTGEAFAVKXXXXXXXXXXX-XXELAEIEPKLAQLAAAGNPGVVQVHAVYED 271 +V + + TG+ +A+K E E ++ + +P +V +H ++ Sbjct: 65 LVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHTRQ-SPFLVTLHYAFQT 123 Query: 272 DSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKPD 451 ++ H+++D +G +L + L + E V ++ AL H+ G+I+RD+K + Sbjct: 124 ETKLHLILDYINGGEL--FTHLSQRERFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLE 181 Query: 452 NVVLDVDDEGENGSPRARLADFGSAAWIGAD 544 N++LD NG L DFG + AD Sbjct: 182 NILLD-----SNG--HVMLTDFGLSKEFVAD 205
>KS6A5_HUMAN (O75582) Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1) (Nuclear| mitogen-and stress-activated protein kinase 1) (90 kDa ribosomal protein S6 kinase 5) (RSK-like protein kinase) (RSKL) Length = 802 Score = 68.6 bits (166), Expect = 1e-11 Identities = 42/147 (28%), Positives = 76/147 (51%), Gaps = 1/147 (0%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAA-GNPGVVQVHAVY 265 F + +C + + +AFAVK A + ++ L G+P +V++H V+ Sbjct: 437 FSICRKCVHKKSNQAFAVKIISKRME--------ANTQKEITALKLCEGHPNIVKLHEVF 488 Query: 266 EDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVK 445 D T +VM+L +G +L + R+++ E A+ I+ +L A++ H GV+HRD+K Sbjct: 489 HDQLHTFLVMELLNGGELFE--RIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHRDLK 546 Query: 446 PDNVVLDVDDEGENGSPRARLADFGSA 526 P+N++ EN + ++ DFG A Sbjct: 547 PENLLF----TDENDNLEIKIIDFGFA 569 Score = 44.7 bits (104), Expect = 2e-04 Identities = 29/104 (27%), Positives = 53/104 (50%) Frame = +2 Query: 233 NPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALC 412 +P +V +H ++ ++ H+++D +G +L + L + E V ++ AL Sbjct: 111 SPFLVTLHYAFQTETKLHLILDYINGGEL--FTHLSQRERFTEHEVQIYVGEIVLALEHL 168 Query: 413 HRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSAAWIGAD 544 H+ G+I+RD+K +N++LD NG L DFG + AD Sbjct: 169 HKLGIIYRDIKLENILLD-----SNG--HVVLTDFGLSKEFVAD 205
>CDKL1_MOUSE (Q8CEQ0) Cyclin-dependent kinase-like 1 (EC 2.7.11.22)| Length = 352 Score = 68.6 bits (166), Expect = 1e-11 Identities = 47/154 (30%), Positives = 70/154 (45%), Gaps = 1/154 (0%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXX-XXXXXELAEIEPKLAQLAAAGNPGVVQVHAVY 265 +GVV +C +R TG+ A+K L EI L +P +V + V+ Sbjct: 15 YGVVFKCRNRDTGQIVAIKRFLETEDDPVIKKIALREIR----MLKQLKHPNLVNLLEVF 70 Query: 266 EDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVK 445 H+V + C L + R +RG VPEP+ +I Q QA+ CH+ IHRDVK Sbjct: 71 RRKRRLHLVFEYCDHTVLHELDRYQRG--VPEPLVKNITWQTLQAVNFCHKHNCIHRDVK 128 Query: 446 PDNVVLDVDDEGENGSPRARLADFGSAAWIGADG 547 P+N+++ +L DFG A + G Sbjct: 129 PENILI-------TKQSAIKLCDFGFARLLTGPG 155
>ROCK2_RAT (Q62868) Rho-associated protein kinase 2 (EC 2.7.11.1)| (Rho-associated, coiled-coil-containing protein kinase 2) (p164 ROCK-2) (RhoA-binding kinase 2) (p150 ROK-alpha) (ROKalpha) Length = 1379 Score = 68.6 bits (166), Expect = 1e-11 Identities = 50/157 (31%), Positives = 74/157 (47%) Frame = +2 Query: 53 DYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAG 232 DY FG V +++ + +A+K E + +A A Sbjct: 82 DYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDI--MAFAN 139 Query: 233 NPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALC 412 +P VVQ+ ++DD + +MVM+ G DL V L VPE A A++ AL Sbjct: 140 SPWVVQLFCAFQDDRYLYMVMEYMPGGDL---VNLMSNYDVPEKWAKFYTAEVVLALDAI 196 Query: 413 HRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGS 523 H G+IHRDVKPDN++LD ++G +LADFG+ Sbjct: 197 HSMGLIHRDVKPDNMLLD-----KHG--HLKLADFGT 226
>ROCK2_MOUSE (P70336) Rho-associated protein kinase 2 (EC 2.7.11.1)| (Rho-associated, coiled-coil-containing protein kinase 2) (p164 ROCK-2) Length = 1388 Score = 68.6 bits (166), Expect = 1e-11 Identities = 50/157 (31%), Positives = 74/157 (47%) Frame = +2 Query: 53 DYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAG 232 DY FG V +++ + +A+K E + +A A Sbjct: 91 DYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDI--MAFAN 148 Query: 233 NPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALC 412 +P VVQ+ ++DD + +MVM+ G DL V L VPE A A++ AL Sbjct: 149 SPWVVQLFCAFQDDRYLYMVMEYMPGGDL---VNLMSNYDVPEKWAKFYTAEVVLALDAI 205 Query: 413 HRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGS 523 H G+IHRDVKPDN++LD ++G +LADFG+ Sbjct: 206 HSMGLIHRDVKPDNMLLD-----KHG--HLKLADFGT 235
>PKAB_STRCO (P54740) Serine/threonine protein kinase pkaB (EC 2.7.11.1)| Length = 417 Score = 68.2 bits (165), Expect = 2e-11 Identities = 45/107 (42%), Positives = 56/107 (52%), Gaps = 1/107 (0%) Frame = +2 Query: 218 LAAAGNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQ 397 L +P VV V + D + +VMDL G DL RL R + A +VA +A Sbjct: 59 LLGLDHPHVVSVRDLVVDGNDLALVMDLVRGTDLR--TRLDRERRLAPEAAVAVVADVAD 116 Query: 398 ALALCHRRGVIHRDVKPDNVVLDVDDE-GENGSPRARLADFGSAAWI 535 LA H GV+HRDVKP+NV+LD+ G GS A L DFG A I Sbjct: 117 GLAAAHAAGVVHRDVKPENVLLDMQGPLGPGGSHPALLTDFGVAKLI 163
>KS6A4_MOUSE (Q9Z2B9) Ribosomal protein S6 kinase alpha-4 (EC 2.7.11.1) (Nuclear| mitogen-and stress-activated protein kinase 2) (90 kDa ribosomal protein S6 kinase 4) (RSK-like protein kinase) (RLSK) Length = 773 Score = 68.2 bits (165), Expect = 2e-11 Identities = 48/147 (32%), Positives = 74/147 (50%), Gaps = 1/147 (0%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 F V RC R +G+ FAVK E+A + +L Q +P VV +H V Sbjct: 422 FSVCRRCRQRQSGQEFAVKILSRRLEENTQR-EVAAL--RLCQ----SHPNVVNLHEVLH 474 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRR-GVIHRDVK 445 D T++V++L G +LL+ +R +R E A+ I+ L A++ H GV+HRD+K Sbjct: 475 DQLHTYLVLELLRGGELLEHIRKKR--LFSESEASQILRSLVSAVSFMHEEAGVVHRDLK 532 Query: 446 PDNVVLDVDDEGENGSPRARLADFGSA 526 P+N++ D G ++ DFG A Sbjct: 533 PENILYADDTPG----APVKIIDFGFA 555 Score = 41.2 bits (95), Expect = 0.002 Identities = 22/77 (28%), Positives = 42/77 (54%) Frame = +2 Query: 236 PGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCH 415 P +V +H ++ D+ H+++D SG ++ + L + E ++ AL H Sbjct: 96 PFLVTLHYAFQTDAKLHLILDYVSGGEM--FTHLYQRQYFKEAEVRVYGGEIVLALEHLH 153 Query: 416 RRGVIHRDVKPDNVVLD 466 + G+I+RD+K +NV+LD Sbjct: 154 KLGIIYRDLKLENVLLD 170
>DMPK_HUMAN (Q09013) Myotonin-protein kinase (EC 2.7.11.1) (Myotonic dystrophy| protein kinase) (MDPK) (DM-kinase) (DMK) (DMPK) (MT-PK) Length = 639 Score = 68.2 bits (165), Expect = 2e-11 Identities = 36/102 (35%), Positives = 59/102 (57%) Frame = +2 Query: 242 VVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRR 421 + Q+H ++D+++ ++VM+ G DLL + + G +P +A +A++ A+ HR Sbjct: 141 ITQLHFAFQDENYLYLVMEYYVGGDLLTLLS-KFGERIPAEMARFYLAEIVMAIDSVHRL 199 Query: 422 GVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSAAWIGADG 547 G +HRD+KPDN++LD RLADFGS + ADG Sbjct: 200 GYVHRDIKPDNILLD-------RCGHIRLADFGSCLKLRADG 234
>ROCK2_HUMAN (O75116) Rho-associated protein kinase 2 (EC 2.7.11.1)| (Rho-associated, coiled-coil-containing protein kinase 2) (p164 ROCK-2) (Rho kinase 2) Length = 1388 Score = 67.8 bits (164), Expect = 2e-11 Identities = 50/157 (31%), Positives = 74/157 (47%) Frame = +2 Query: 53 DYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAG 232 DY FG V +++ + +A+K E + +A A Sbjct: 91 DYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDI--MAFAN 148 Query: 233 NPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALC 412 +P VVQ+ ++DD + +MVM+ G DL V L VPE A A++ AL Sbjct: 149 SPWVVQLFYAFQDDRYLYMVMEYMPGGDL---VNLMSNYDVPEKWAKFYTAEVVLALDAI 205 Query: 413 HRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGS 523 H G+IHRDVKPDN++LD ++G +LADFG+ Sbjct: 206 HSMGLIHRDVKPDNMLLD-----KHG--HLKLADFGT 235
>CDS1_SCHPO (Q09170) Serine/threonine-protein kinase cds1 (EC 2.7.11.1)| (Checkpoint kinase cds1) Length = 460 Score = 67.8 bits (164), Expect = 2e-11 Identities = 45/169 (26%), Positives = 77/169 (45%), Gaps = 2/169 (1%) Frame = +2 Query: 47 NRDYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAE--IEPKLAQL 220 N Y F VV ++G+ +A+K + A + ++ L Sbjct: 164 NSHYEIIRTLGSGTFAVVKLAVEVNSGKWYAIKIINKRKILLTSSEKRATEMFQREIDIL 223 Query: 221 AAAGNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQA 400 + +PGVVQ H ++E+D +VM+ G DL+D+ L + E ++ QL + Sbjct: 224 KSLHHPGVVQCHEIFENDDELFIVMEYVEGGDLMDF--LIANGSIDEQDCKPLLKQLLET 281 Query: 401 LALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSAAWIGADG 547 L H++GV HRD+KP+N+++ D +++DFG A I G Sbjct: 282 LLHLHKQGVTHRDIKPENILITNDF-------HLKISDFGLAKVIHGTG 323
>BRSK2_HUMAN (Q8IWQ3) BR serine/threonine-protein kinase 2 (EC 2.7.11.1)| (Serine/threonine-protein kinase 29) (SAD1B) Length = 736 Score = 67.8 bits (164), Expect = 2e-11 Identities = 37/114 (32%), Positives = 67/114 (58%) Frame = +2 Query: 188 LAEIEPKLAQLAAAGNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPV 367 L ++E ++A L +P V+++H VYE+ + ++V++ SG +L D++ +++G P+ Sbjct: 60 LMKVEREIAILKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYL-VKKGRLTPKE- 117 Query: 368 AADIVAQLAQALALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSAA 529 A Q+ AL CH + HRD+KP+N++LD + R+ADFG A+ Sbjct: 118 ARKFFRQIISALDFCHSHSICHRDLKPENLLLDEKN-------NIRIADFGMAS 164
>CCAMK_LILLO (Q43531) Calcium and calcium/calmodulin-dependent| serine/threonine-protein kinase (EC 2.7.11.17) (LlCCaMK) Length = 520 Score = 67.4 bits (163), Expect = 3e-11 Identities = 32/74 (43%), Positives = 48/74 (64%) Frame = +2 Query: 233 NPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALC 412 +P V+ +H VYED + H+V++LCSG +L D R+ E AA++V Q+A LA Sbjct: 101 HPNVIHLHDVYEDANGVHLVLELCSGGELFD--RIVAQDRYSESEAAEVVQQIASGLAAL 158 Query: 413 HRRGVIHRDVKPDN 454 H+ +IHRD+KP+N Sbjct: 159 HKSTIIHRDLKPEN 172
>BRSK1_HUMAN (Q8TDC3) BR serine/threonine-protein kinase 1 (EC 2.7.11.1) (SAD1| kinase) (SAD1A) Length = 794 Score = 67.4 bits (163), Expect = 3e-11 Identities = 37/114 (32%), Positives = 67/114 (58%) Frame = +2 Query: 188 LAEIEPKLAQLAAAGNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPV 367 L ++E ++A L +P V+++H VYE+ + ++V++ SG +L D++ +++G P+ Sbjct: 91 LMKVEREIAILKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYL-VKKGRLTPKE- 148 Query: 368 AADIVAQLAQALALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSAA 529 A Q+ AL CH + HRD+KP+N++LD + R+ADFG A+ Sbjct: 149 ARKFFRQIVSALDFCHSYSICHRDLKPENLLLDEKN-------NIRIADFGMAS 195
>CDKL1_RAT (Q66HE7) Cyclin-dependent kinase-like 1 (EC 2.7.11.22)| Length = 352 Score = 67.4 bits (163), Expect = 3e-11 Identities = 47/154 (30%), Positives = 70/154 (45%), Gaps = 1/154 (0%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXX-XXXXXELAEIEPKLAQLAAAGNPGVVQVHAVY 265 +GVV +C +R TG+ A+K L EI L +P +V + V+ Sbjct: 15 YGVVFKCRNRDTGQIVAIKRFLETEDDPVIKKIALREIR----MLKQLKHPNLVSLLEVF 70 Query: 266 EDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVK 445 H+V + C L + R +RG VPEP+ +I Q QA+ CH+ IHRDVK Sbjct: 71 RRKRRLHLVFEYCHHTVLHELDRYQRG--VPEPLVKNITWQTLQAVNFCHKHNCIHRDVK 128 Query: 446 PDNVVLDVDDEGENGSPRARLADFGSAAWIGADG 547 P+N+++ +L DFG A + G Sbjct: 129 PENILITKHSV-------IKLCDFGFARLLTGPG 155
>KCC2A_RAT (P11275) Calcium/calmodulin-dependent protein kinase type II alpha| chain (EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II alpha subunit) Length = 478 Score = 67.0 bits (162), Expect = 3e-11 Identities = 46/161 (28%), Positives = 78/161 (48%), Gaps = 8/161 (4%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 F VV RC G+ +A K +L E E ++ +L +P +V++H Sbjct: 24 FSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKL-EREARICRLLK--HPNIVRLHDSIS 80 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 ++ +++ DL +G +L + + R E A+ + Q+ +A+ CH+ GV+HRD+KP Sbjct: 81 EEGHHYLIFDLVTGGELFEDIVAREY--YSEADASHCIQQILEAVLHCHQMGVVHRDLKP 138 Query: 449 DNVVLDVDDEGENGSPRARLADFGSA--------AWIGADG 547 +N++L +G +LADFG A AW G G Sbjct: 139 ENLLLASKLKG----AAVKLADFGLAIEVEGEQQAWFGFAG 175
>KCC2A_PONPY (Q5RCC4) Calcium/calmodulin-dependent protein kinase type II alpha| chain (EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II alpha subunit) Length = 478 Score = 67.0 bits (162), Expect = 3e-11 Identities = 46/161 (28%), Positives = 78/161 (48%), Gaps = 8/161 (4%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 F VV RC G+ +A K +L E E ++ +L +P +V++H Sbjct: 24 FSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKL-EREARICRLLK--HPNIVRLHDSIS 80 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 ++ +++ DL +G +L + + R E A+ + Q+ +A+ CH+ GV+HRD+KP Sbjct: 81 EEGHHYLIFDLVTGGELFEDIVAREY--YSEADASHCIQQILEAVLHCHQMGVVHRDLKP 138 Query: 449 DNVVLDVDDEGENGSPRARLADFGSA--------AWIGADG 547 +N++L +G +LADFG A AW G G Sbjct: 139 ENLLLASKLKG----AAVKLADFGLAIEVEGEQQAWFGFAG 175
>KCC2A_HUMAN (Q9UQM7) Calcium/calmodulin-dependent protein kinase type II alpha| chain (EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II alpha subunit) Length = 478 Score = 67.0 bits (162), Expect = 3e-11 Identities = 46/161 (28%), Positives = 78/161 (48%), Gaps = 8/161 (4%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 F VV RC G+ +A K +L E E ++ +L +P +V++H Sbjct: 24 FSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKL-EREARICRLLK--HPNIVRLHDSIS 80 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 ++ +++ DL +G +L + + R E A+ + Q+ +A+ CH+ GV+HRD+KP Sbjct: 81 EEGHHYLIFDLVTGGELFEDIVAREY--YSEADASHCIQQILEAVLHCHQMGVVHRDLKP 138 Query: 449 DNVVLDVDDEGENGSPRARLADFGSA--------AWIGADG 547 +N++L +G +LADFG A AW G G Sbjct: 139 ENLLLASKLKG----AAVKLADFGLAIEVEGEQQAWFGFAG 175
>KS6A3_MOUSE (P18654) Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1)| (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B) Length = 740 Score = 66.2 bits (160), Expect = 6e-11 Identities = 45/155 (29%), Positives = 77/155 (49%), Gaps = 1/155 (0%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 + V RC ++T FAVK E+ L +P ++ + VY+ Sbjct: 433 YSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEIL--------LRYGQHPNIITLKDVYD 484 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 D + ++V +L G +LLD ++ R E A+ ++ + + + H +GV+HRD+KP Sbjct: 485 DGKYVYVVTELMKGGELLD--KILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKP 542 Query: 449 DNVVLDVDDEGENGSPRA-RLADFGSAAWIGADGG 550 N +L VD E+G+P + R+ DFG A + A+ G Sbjct: 543 SN-ILYVD---ESGNPESIRICDFGFAKQLRAENG 573 Score = 53.9 bits (128), Expect = 3e-07 Identities = 32/101 (31%), Positives = 55/101 (54%) Frame = +2 Query: 218 LAAAGNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQ 397 L +P +V++H ++ + ++++D G DL + RL + E +A+LA Sbjct: 122 LVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDL--FTRLSKEVMFTEEDVKFYLAELAL 179 Query: 398 ALALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFG 520 AL H G+I+RD+KP+N++L D+EG +L DFG Sbjct: 180 ALDHLHSLGIIYRDLKPENILL--DEEG-----HIKLTDFG 213
>KS6A3_HUMAN (P51812) Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1)| (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protei Length = 740 Score = 66.2 bits (160), Expect = 6e-11 Identities = 45/155 (29%), Positives = 77/155 (49%), Gaps = 1/155 (0%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 + V RC ++T FAVK E+ L +P ++ + VY+ Sbjct: 433 YSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEIL--------LRYGQHPNIITLKDVYD 484 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 D + ++V +L G +LLD ++ R E A+ ++ + + + H +GV+HRD+KP Sbjct: 485 DGKYVYVVTELMKGGELLD--KILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKP 542 Query: 449 DNVVLDVDDEGENGSPRA-RLADFGSAAWIGADGG 550 N +L VD E+G+P + R+ DFG A + A+ G Sbjct: 543 SN-ILYVD---ESGNPESIRICDFGFAKQLRAENG 573 Score = 53.9 bits (128), Expect = 3e-07 Identities = 32/101 (31%), Positives = 55/101 (54%) Frame = +2 Query: 218 LAAAGNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQ 397 L +P +V++H ++ + ++++D G DL + RL + E +A+LA Sbjct: 122 LVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDL--FTRLSKEVMFTEEDVKFYLAELAL 179 Query: 398 ALALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFG 520 AL H G+I+RD+KP+N++L D+EG +L DFG Sbjct: 180 ALDHLHSLGIIYRDLKPENILL--DEEG-----HIKLTDFG 213
>DMPK_MOUSE (P54265) Myotonin-protein kinase (EC 2.7.11.1) (Myotonic dystrophy| protein kinase) (MDPK) (DM-kinase) (DMK) (DMPK) (MT-PK) Length = 631 Score = 66.2 bits (160), Expect = 6e-11 Identities = 35/102 (34%), Positives = 58/102 (56%) Frame = +2 Query: 242 VVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRR 421 + Q+H ++D+++ ++VM+ G DLL + + G +P +A +A++ A+ HR Sbjct: 131 ITQLHFAFQDENYLYLVMEYYVGGDLLTLLS-KFGERIPAEMARFYLAEIVMAIDSVHRL 189 Query: 422 GVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSAAWIGADG 547 G +HRD+KPDN++LD RLADFGS + DG Sbjct: 190 GYVHRDIKPDNILLD-------RCGHIRLADFGSCLKLQPDG 224
>PKNF_MYCTU (P72003) Probable serine/threonine-protein kinase pknF (EC| 2.7.11.1) Length = 476 Score = 66.2 bits (160), Expect = 6e-11 Identities = 38/110 (34%), Positives = 56/110 (50%) Frame = +2 Query: 221 AAAGNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQA 400 A+ +P +V VH E D + MD G D + +R R +P P +I+ +A+A Sbjct: 65 ASLWHPHIVAVHDRGEFDGQLWIDMDFVDGTDTVSLLRDRYPNGMPGPEVTEIITAVAEA 124 Query: 401 LALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSAAWIGADGG 550 L H R ++HRDVKP N+++ D + R LADFG A W+ G Sbjct: 125 LDYAHERRLLHRDVKPANILIANPDSPDR---RIMLADFGIAGWVDDPSG 171
>PKNF_MYCBO (Q7TZN1) Probable serine/threonine-protein kinase pknF (EC| 2.7.11.1) Length = 476 Score = 66.2 bits (160), Expect = 6e-11 Identities = 38/110 (34%), Positives = 56/110 (50%) Frame = +2 Query: 221 AAAGNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQA 400 A+ +P +V VH E D + MD G D + +R R +P P +I+ +A+A Sbjct: 65 ASLWHPHIVAVHDRGEFDGQLWIDMDFVDGTDTVSLLRDRYPNGMPGPEVTEIITAVAEA 124 Query: 401 LALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSAAWIGADGG 550 L H R ++HRDVKP N+++ D + R LADFG A W+ G Sbjct: 125 LDYAHERRLLHRDVKPANILIANPDSPDR---RIMLADFGIAGWVDDPSG 171
>PHKG2_MOUSE (Q9DB30) Phosphorylase b kinase gamma catalytic chain, testis/liver| isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase gamma subunit 2) Length = 406 Score = 66.2 bits (160), Expect = 6e-11 Identities = 44/154 (28%), Positives = 73/154 (47%), Gaps = 5/154 (3%) Frame = +2 Query: 95 VVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQ-----LAAAGNPGVVQVHA 259 VV RC R+TG+ FAVK +L E+ + AG+P ++ + Sbjct: 37 VVRRCVHRATGDEFAVKIMEVSAERLSLE-QLEEVRDATRREMHILRQVAGHPHIITLID 95 Query: 260 VYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRD 439 YE S+ +V DL +L D+ L + E I+ L +A++ H ++HRD Sbjct: 96 SYESSSFMFLVFDLMRKGELFDY--LTEKVALSEKETRSIMRSLLEAVSFLHANNIVHRD 153 Query: 440 VKPDNVVLDVDDEGENGSPRARLADFGSAAWIGA 541 +KP+N++LD + + RL+DFG + + A Sbjct: 154 LKPENILLD-------DNMQIRLSDFGFSCHLEA 180
>MRCKG_MOUSE (Q80UW5) Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1)| (CDC42-binding protein kinase gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (Myotonic dystrophy protein kinase-like alpha) (MRCK gamma) (DMPK-like gamma Length = 1551 Score = 66.2 bits (160), Expect = 6e-11 Identities = 48/153 (31%), Positives = 75/153 (49%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 FG V R +G+ FA+K E A + L + V +H ++ Sbjct: 82 FGEVAVVRQRGSGQIFAMKMLHKWEMLKRA--ETACFREERDVLVKGDSRWVTALHYAFQ 139 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 D+ + ++VMD +G DLL + R +P +A +A++ A+ H+ G +HRDVKP Sbjct: 140 DEEYLYLVMDYYAGGDLLTLLS-RFEDRLPPELAQFYLAEMVLAIHSLHQLGYVHRDVKP 198 Query: 449 DNVVLDVDDEGENGSPRARLADFGSAAWIGADG 547 DN++LD+ NG RLADFGS + +G Sbjct: 199 DNILLDM-----NG--HIRLADFGSCLRLNNNG 224
>KGP2_RAT (Q64595) cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2)| (cGKII) (Type II cGMP-dependent protein kinase) Length = 762 Score = 66.2 bits (160), Expect = 6e-11 Identities = 44/151 (29%), Positives = 74/151 (49%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 FG V ++ AFA+K E E ++ L +P +V+++ ++ Sbjct: 464 FGRVELVKVKNENIAFAMKCIRKKHIVDTKQQEHVYSEKRI--LEELCSPFIVKLYRTFK 521 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 D+ + +M+++ C G +L W LR EP + VA + +A HR G+I+RD+KP Sbjct: 522 DNKYVYMLLEACLGGEL--WSILRDRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKP 579 Query: 449 DNVVLDVDDEGENGSPRARLADFGSAAWIGA 541 +N++LD D +L DFG A IG+ Sbjct: 580 ENLILDADG-------YLKLVDFGFAKKIGS 603
>CBK1_KLULA (P31034) Serine/threonine-protein kinase CBK1 (EC 2.7.11.1)| Length = 718 Score = 66.2 bits (160), Expect = 6e-11 Identities = 41/156 (26%), Positives = 74/156 (47%) Frame = +2 Query: 53 DYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAG 232 D+ FG V + TG+ +A+K +LA ++ + LA + Sbjct: 302 DFNSVKVIGKGAFGEVRLVQKKDTGKIYAMKTLLKSEMYNKD--QLAHVKAERDVLAGSD 359 Query: 233 NPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALC 412 +P VV ++ ++D + +++M+ G DL+ L R E V +A+ A+ + Sbjct: 360 SPWVVSLYYSFQDSQYLYLIMEFLPGGDLM--TMLIRWQIFTEDVTRFYMAECILAIEVI 417 Query: 413 HRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFG 520 H+ G IHRD+KPDN+++D+ +L+DFG Sbjct: 418 HKLGFIHRDIKPDNILIDI-------RGHIKLSDFG 446
>KAPA_YEAST (P06244) cAMP-dependent protein kinase type 1 (EC 2.7.11.11) (PKA| 1) (CDC25-suppressing protein kinase) (PK-25) Length = 397 Score = 65.9 bits (159), Expect = 8e-11 Identities = 44/162 (27%), Positives = 74/162 (45%) Frame = +2 Query: 50 RDYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAA 229 +D+ FG VH SR G +A+K E E + L+ Sbjct: 85 QDFQILRTLGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERLM--LSIV 142 Query: 230 GNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALAL 409 +P ++++ ++D M+MD G +L LR+ P PVA A++ AL Sbjct: 143 THPFIIRMWGTFQDAQQIFMIMDYIEGGELFSL--LRKSQRFPNPVAKFYAAEVCLALEY 200 Query: 410 CHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSAAWI 535 H + +I+RD+KP+N++LD +NG ++ DFG A ++ Sbjct: 201 LHSKDIIYRDLKPENILLD-----KNG--HIKITDFGFAKYV 235
>KS6AA_CHICK (P18652) Ribosomal protein S6 kinase 2 alpha (EC 2.7.11.1)| (Ribosomal protein S6 kinase II alpha) (S6KII-alpha) (P90-RSK) (MAP kinase-activated protein kinase 1) (MAPK-activated protein kinase 1) (MAPKAP kinase 1) (MAPKAPK-1) Length = 752 Score = 65.9 bits (159), Expect = 8e-11 Identities = 44/155 (28%), Positives = 77/155 (49%), Gaps = 1/155 (0%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 + V RC ++T +AVK E+ L +P ++ + VY+ Sbjct: 446 YSVCKRCIHKTTNMEYAVKVIDKSKRDPSEEIEIL--------LRYGQHPNIITLKDVYD 497 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 D + ++V +L G +LLD ++ R E A+ ++ + + + H +GV+HRD+KP Sbjct: 498 DGKYVYLVTELMRGGELLD--KILRQKFFSEREASSVLHTICKTVEYLHSQGVVHRDLKP 555 Query: 449 DNVVLDVDDEGENGSPRA-RLADFGSAAWIGADGG 550 N +L VD E+G+P + R+ DFG A + A+ G Sbjct: 556 SN-ILYVD---ESGNPESIRICDFGFAKQLRAENG 586 Score = 53.9 bits (128), Expect = 3e-07 Identities = 33/101 (32%), Positives = 55/101 (54%) Frame = +2 Query: 218 LAAAGNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQ 397 LA +P VV++H ++ + ++++D G DL + RL + E +A+LA Sbjct: 134 LADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDL--FTRLSKEVMFTEEDVKFYLAELAL 191 Query: 398 ALALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFG 520 L H G+I+RD+KP+N++L D+EG +L DFG Sbjct: 192 GLDHLHSLGIIYRDLKPENILL--DEEG-----HIKLTDFG 225
>CBK1_DEBHA (Q6BLJ9) Serine/threonine-protein kinase CBK1 (EC 2.7.11.1)| Length = 716 Score = 65.9 bits (159), Expect = 8e-11 Identities = 41/156 (26%), Positives = 73/156 (46%) Frame = +2 Query: 53 DYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAG 232 D+ FG V R TG+ +A+K +LA ++ + LA + Sbjct: 314 DFNTVKVIGKGAFGEVRLVQKRDTGKIYAMKTLLKSEMYKKD--QLAHVKAERDVLAGSD 371 Query: 233 NPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALC 412 +P VV ++ ++D + +++M+ G DL+ L R E + +A+ A+ Sbjct: 372 SPWVVSLYYSFQDAQYLYLIMEFLPGGDLM--TMLIRWQIFTEDITRFYMAECVLAIEAI 429 Query: 413 HRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFG 520 H+ G IHRD+KPDN+++D+ +L+DFG Sbjct: 430 HKLGFIHRDIKPDNILIDI-------RGHIKLSDFG 458
>PKN2_MYXXA (P54736) Serine/threonine-protein kinase pkn2 (EC 2.7.11.1)| Length = 830 Score = 65.9 bits (159), Expect = 8e-11 Identities = 48/151 (31%), Positives = 70/151 (46%) Frame = +2 Query: 92 GVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYED 271 G V+ S G A+K E + E +L L+A +P VV++ E Sbjct: 25 GEVYLGEQVSLGRKVAIKVLHHDLHAQAGMAERFKREARL--LSAVEHPAVVRIVDFGES 82 Query: 272 DSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKPD 451 +VM+ G L D + P+P A ++ QLA+ LA H +G+IHRD+KP+ Sbjct: 83 GDHACLVMEFVEGESLYD---VLTPGPMPPGRALPLLQQLAEGLAAIHDKGIIHRDLKPE 139 Query: 452 NVVLDVDDEGENGSPRARLADFGSAAWIGAD 544 NV + GE +ARL DFG A + D Sbjct: 140 NVFISKSARGE----QARLLDFGIARLVEPD 166
>CCAMK_MEDTR (Q6RET7) Calcium and calcium/calmodulin-dependent| serine/threonine-protein kinase DMI-3 (EC 2.7.11.17) (Does not make infections protein 3) (CCaMK DMI3) (MtCCaMK) Length = 523 Score = 65.9 bits (159), Expect = 8e-11 Identities = 38/97 (39%), Positives = 57/97 (58%), Gaps = 1/97 (1%) Frame = +2 Query: 233 NPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALC 412 +P V+ ++ VYED + H+V++LCSG +L D R+ E AA +V Q+A L Sbjct: 105 HPNVIDLYDVYEDTNGVHLVLELCSGGELFD--RIVAQDKYSETEAATVVHQIASGLEAV 162 Query: 413 HRRGVIHRDVKPDN-VVLDVDDEGENGSPRARLADFG 520 HR ++HRD+KP+N + LDV SP ++ DFG Sbjct: 163 HRANIVHRDLKPENCLFLDV----RKDSP-LKIMDFG 194
>CAKI_DROME (Q24210) Calcium/calmodulin-dependent protein kinase (EC 2.7.11.17)| (CAKI) (Peripheral plasma membrane protein CaMGUK) Length = 898 Score = 65.5 bits (158), Expect = 1e-10 Identities = 43/148 (29%), Positives = 66/148 (44%), Gaps = 2/148 (1%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 F +V RC R + + FAVK A+++ + +P +V++ Y Sbjct: 23 FSIVRRCIHRESNQQFAVKIVDVAKFTASPGLSTADLKREATICHMLKHPHIVELLETYS 82 Query: 269 DDSWTHMVMDLCSGPDLLDWV--RLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDV 442 + +MV + G DL V R G E VA + Q+ +AL CH ++HRDV Sbjct: 83 SEGMLYMVFEFMEGSDLCFEVVRRAVAGFVYSEAVACHYMRQILEALRYCHENDILHRDV 142 Query: 443 KPDNVVLDVDDEGENGSPRARLADFGSA 526 +P +L D N +P +L FGSA Sbjct: 143 RPACALLATVD---NSAP-VKLGGFGSA 166
>PHKG2_HUMAN (P15735) Phosphorylase b kinase gamma catalytic chain, testis/liver| isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase gamma subunit 2) (PSK-C3) Length = 406 Score = 65.1 bits (157), Expect = 1e-10 Identities = 43/146 (29%), Positives = 69/146 (47%), Gaps = 4/146 (2%) Frame = +2 Query: 95 VVHRCTSRSTGEAFAVKXXXXXXXXXX--XXXELAEIEPKLAQLA--AAGNPGVVQVHAV 262 VV RC R+TG FAVK E+ E + + AG+P ++ + Sbjct: 37 VVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETHILRQVAGHPHIITLIDS 96 Query: 263 YEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDV 442 YE S+ +V DL +L D+ L + E I+ L +A++ H ++HRD+ Sbjct: 97 YESSSFMFLVFDLMRKGELFDY--LTEKVALSEKETRSIMRSLLEAVSFLHANNIVHRDL 154 Query: 443 KPDNVVLDVDDEGENGSPRARLADFG 520 KP+N++LD + + RL+DFG Sbjct: 155 KPENILLD-------DNMQIRLSDFG 173
>KGP2_HUMAN (Q13237) cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2)| (cGKII) (Type II cGMP-dependent protein kinase) Length = 762 Score = 65.1 bits (157), Expect = 1e-10 Identities = 43/151 (28%), Positives = 74/151 (49%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 FG V ++ AFA+K E E ++ L +P +V+++ ++ Sbjct: 464 FGRVELVKVKNENVAFAMKCIRKKHIVDTKQQEHVYSEKRI--LEELCSPFIVKLYRTFK 521 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 D+ + +M+++ C G +L W LR EP + VA + +A HR G+I+RD+KP Sbjct: 522 DNKYVYMLLEACLGGEL--WSILRDRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKP 579 Query: 449 DNVVLDVDDEGENGSPRARLADFGSAAWIGA 541 +N++LD + +L DFG A IG+ Sbjct: 580 ENLILDAEG-------YLKLVDFGFAKKIGS 603
>CBK1_ASHGO (Q754N7) Serine/threonine-protein kinase CBK1 (EC 2.7.11.1)| Length = 719 Score = 64.7 bits (156), Expect = 2e-10 Identities = 41/156 (26%), Positives = 73/156 (46%) Frame = +2 Query: 53 DYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAG 232 D+ FG V + TG+ +A+K +LA ++ + LA + Sbjct: 309 DFHTVKVIGKGAFGEVRLVQKKDTGKIYAMKTLLKSEMYKKD--QLAHVKAERDVLAGSD 366 Query: 233 NPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALC 412 +P VV ++ ++D + +++M+ G DL+ L R E V +A+ A+ Sbjct: 367 SPWVVSLYYSFQDAQYLYLIMEFLPGGDLM--TMLIRWQIFTEDVTRFYMAECILAIEAI 424 Query: 413 HRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFG 520 H+ G IHRD+KPDN+++D+ +L+DFG Sbjct: 425 HKLGFIHRDIKPDNILIDI-------RGHIKLSDFG 453
>CPK15_ARATH (P92937) CBL-interacting serine/threonine-protein kinase 15 (EC| 2.7.11.1) (Serine/threonine-protein kinase ATPK10) (SOS2-like protein kinase PKS3) (SOS-interacting protein 2) (SNF1-related kinase 3.1) Length = 421 Score = 64.7 bits (156), Expect = 2e-10 Identities = 43/147 (29%), Positives = 75/147 (51%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 F V+ TG++ A+K E +I+ +++ + +P +V++H V Sbjct: 23 FAKVYHARHLKTGDSVAIKVIDKERILKVGMTE--QIKREISAMRLLRHPNIVELHEVMA 80 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 S + VM+ G +L + V + + E VA QL +A+ CH RGV HRD+KP Sbjct: 81 TKSKIYFVMEHVKGGELFNKVSTGK---LREDVARKYFQQLVRAVDFCHSRGVCHRDLKP 137 Query: 449 DNVVLDVDDEGENGSPRARLADFGSAA 529 +N++LD E+G+ +++DFG +A Sbjct: 138 ENLLLD-----EHGN--LKISDFGLSA 157
>CBK1_YEAST (P53894) Serine/threonine-protein kinase CBK1 (EC 2.7.11.1) (Cell| wall biosynthesis kinase) Length = 756 Score = 64.7 bits (156), Expect = 2e-10 Identities = 41/156 (26%), Positives = 73/156 (46%) Frame = +2 Query: 53 DYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAG 232 D+ FG V + TG+ +A+K +LA ++ + LA + Sbjct: 351 DFHTVKVIGKGAFGEVRLVQKKDTGKIYAMKTLLKSEMYKKD--QLAHVKAERDVLAGSD 408 Query: 233 NPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALC 412 +P VV ++ ++D + +++M+ G DL+ L R E V +A+ A+ Sbjct: 409 SPWVVSLYYSFQDAQYLYLIMEFLPGGDLM--TMLIRWQLFTEDVTRFYMAECILAIETI 466 Query: 413 HRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFG 520 H+ G IHRD+KPDN+++D+ +L+DFG Sbjct: 467 HKLGFIHRDIKPDNILIDI-------RGHIKLSDFG 495
>PKAA_STRCO (P54739) Serine/threonine protein kinase pkaA (EC 2.7.11.1)| Length = 543 Score = 64.7 bits (156), Expect = 2e-10 Identities = 40/105 (38%), Positives = 55/105 (52%) Frame = +2 Query: 233 NPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALC 412 +P +V+V + + +VMDL GPDL + LR P+ AA + AQ+A ALA Sbjct: 76 HPNIVRVRDLVVEGELLALVMDLIDGPDLHRY--LRENGPLTPVAAALLTAQIADALAAS 133 Query: 413 HRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSAAWIGADG 547 H GV+HRD+KP NV+L + G L DFG A + G Sbjct: 134 HADGVVHRDLKPANVLL----KQTGGEMHPMLTDFGIARLADSPG 174
>DAPK3_RAT (O88764) Death-associated protein kinase 3 (EC 2.7.11.1) (DAP| kinase 3) (DAP-like kinase) (Dlk) (ZIP-kinase) Length = 448 Score = 64.3 bits (155), Expect = 2e-10 Identities = 42/152 (27%), Positives = 74/152 (48%), Gaps = 1/152 (0%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXX-XXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVY 265 F +V +C + TG +A K EIE +++ L +P ++ +H V+ Sbjct: 24 FAIVRKCQQKGTGMEYAAKFIKKRRLPSSRRGVSREEIEREVSILREIRHPNIITLHDVF 83 Query: 266 EDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVK 445 E+ + ++++L SG +L D+ L + E A + Q+ + H + + H D+K Sbjct: 84 ENKTDVVLILELVSGGELFDF--LAEKESLTEDEATQFLKQILDGVHYLHSKRIAHFDLK 141 Query: 446 PDNVVLDVDDEGENGSPRARLADFGSAAWIGA 541 P+N++L +D SPR +L DFG A I A Sbjct: 142 PENIML-LDKHA--ASPRIKLIDFGIAHRIEA 170
>DAPK3_MOUSE (O54784) Death-associated protein kinase 3 (EC 2.7.11.1) (DAP| kinase 3) (DAP-like kinase) (Dlk) (ZIP-kinase) Length = 448 Score = 64.3 bits (155), Expect = 2e-10 Identities = 42/152 (27%), Positives = 74/152 (48%), Gaps = 1/152 (0%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXX-XXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVY 265 F +V +C + TG +A K EIE +++ L +P ++ +H V+ Sbjct: 24 FAIVRKCQQKGTGMEYAAKFIKKRRLPSSRRGVSREEIEREVSILREIRHPNIITLHDVF 83 Query: 266 EDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVK 445 E+ + ++++L SG +L D+ L + E A + Q+ + H + + H D+K Sbjct: 84 ENKTDVVLILELVSGGELFDF--LAEKESLTEDEATQFLKQILDGVHYLHSKRIAHFDLK 141 Query: 446 PDNVVLDVDDEGENGSPRARLADFGSAAWIGA 541 P+N++L +D SPR +L DFG A I A Sbjct: 142 PENIML-LDKHA--ASPRIKLIDFGIAHRIEA 170
>KPC1_APLCA (Q16974) Calcium-dependent protein kinase C (EC 2.7.11.13) (APL I)| Length = 649 Score = 64.3 bits (155), Expect = 2e-10 Identities = 44/156 (28%), Positives = 73/156 (46%) Frame = +2 Query: 53 DYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAG 232 D+ FG V + T E +A+K E IE ++ L Sbjct: 319 DFNFLTVLGKGSFGKVVLAERKGTDELYAIKILKKDVIIQDDDVECTMIEKRVLALPDKP 378 Query: 233 NPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALC 412 P +VQ+H+ ++ + VM+ +G DL+ R+++ EPVAA A++A L Sbjct: 379 -PFLVQLHSCFQTMDRLYFVMEYVNGGDLM--YRIQQEGKFKEPVAAFYAAEIAIGLFYL 435 Query: 413 HRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFG 520 H +G+++RD+K DNV+LD + ++ADFG Sbjct: 436 HTQGIVYRDLKLDNVMLDAEG-------HIKIADFG 464
>PHKG2_RAT (P31325) Phosphorylase b kinase gamma catalytic chain, testis/liver| isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase gamma subunit 2) Length = 406 Score = 63.9 bits (154), Expect = 3e-10 Identities = 43/147 (29%), Positives = 69/147 (46%), Gaps = 5/147 (3%) Frame = +2 Query: 95 VVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQ-----LAAAGNPGVVQVHA 259 VV RC R+TG+ FAVK +L E+ + AG+P ++ + Sbjct: 37 VVRRCVHRATGDEFAVKIMEVSAERLSLE-QLEEVRDATRREMHILRQVAGHPHIITLID 95 Query: 260 VYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRD 439 YE S+ +V DL +L D+ L + E I+ L +A+ H ++HRD Sbjct: 96 SYESSSFMFLVFDLMRKGELFDY--LTEKVALSEKETRSIMRSLLEAVNFLHVNNIVHRD 153 Query: 440 VKPDNVVLDVDDEGENGSPRARLADFG 520 +KP+N++LD + + RL+DFG Sbjct: 154 LKPENILLD-------DNMQIRLSDFG 173
>CBK1_CANGA (Q6FP74) Serine/threonine-protein kinase CBK1 (EC 2.7.11.1)| Length = 773 Score = 63.9 bits (154), Expect = 3e-10 Identities = 40/156 (25%), Positives = 72/156 (46%) Frame = +2 Query: 53 DYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAG 232 D+ FG V + TG+ +A+K +LA ++ + LA Sbjct: 369 DFHTVQVIGKGAFGEVRLVQKKDTGKIYAMKTLLKSEMYKKD--QLAHVKAERDVLAGTD 426 Query: 233 NPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALC 412 +P +V ++ ++D + +++M+ G DL+ L R E V +A+ A+ Sbjct: 427 SPWIVSLYYSFQDAQYLYLIMEFLPGGDLM--TMLIRWQLFTEDVTRFYMAECILAIETI 484 Query: 413 HRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFG 520 H+ G IHRD+KPDN+++D+ +L+DFG Sbjct: 485 HKLGFIHRDIKPDNILIDI-------RGHIKLSDFG 513
>ORB6_SCHPO (O13310) Serine/threonine-protein kinase orb6 (EC 2.7.11.1)| Length = 469 Score = 63.9 bits (154), Expect = 3e-10 Identities = 42/156 (26%), Positives = 71/156 (45%) Frame = +2 Query: 53 DYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAG 232 D+ FG V TG+ +A+K +LA ++ + L + Sbjct: 92 DFSTIKVIGKGAFGEVRLVQKLDTGKIYAMKSLLKTEMFKRD--QLAHVKAERDLLVESD 149 Query: 233 NPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALC 412 +P VV ++ ++D + +++M+ G DL+ L E V +A+ A+A Sbjct: 150 SPWVVSLYYAFQDSLYLYLIMEFLPGGDLM--TMLINYDTFSEDVTRFYMAECVLAIADV 207 Query: 413 HRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFG 520 HR G IHRD+KPDN+++D D +L+DFG Sbjct: 208 HRMGYIHRDIKPDNILIDRDG-------HIKLSDFG 236
>CCAMK_PEA (Q6RET6) Calcium and calcium/calmodulin-dependent| serine/threonine-protein kinase (EC 2.7.11.17) (PsCCaMK) (Ps-SYM9) (Fragment) Length = 527 Score = 63.9 bits (154), Expect = 3e-10 Identities = 37/97 (38%), Positives = 58/97 (59%), Gaps = 1/97 (1%) Frame = +2 Query: 233 NPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALC 412 +P V+ ++ VYED + H+V++LCSG +L D R+ E A+ +V Q+ L Sbjct: 113 HPNVIDLYDVYEDTNGVHLVLELCSGGELFD--RIVAQDKYSETEASTVVHQIVAGLEAI 170 Query: 413 HRRGVIHRDVKPDN-VVLDVDDEGENGSPRARLADFG 520 HR +IHRD+KP+N + LDV G++ S ++ DFG Sbjct: 171 HRANIIHRDLKPENCLFLDV---GKDSS--LKIMDFG 202
>KGP2_MOUSE (Q61410) cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2)| (cGKII) (Type II cGMP-dependent protein kinase) Length = 762 Score = 63.9 bits (154), Expect = 3e-10 Identities = 43/151 (28%), Positives = 73/151 (48%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 FG V ++ AFA+K E E ++ L +P +V+++ ++ Sbjct: 464 FGRVELVKVKNENVAFAMKCIRKKHIVDTKQQEHVYSEKRI--LEELCSPFIVKLYRTFK 521 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 D+ + +M+++ C G +L W LR EP + VA + +A H G+I+RD+KP Sbjct: 522 DNKYVYMLLEACLGGEL--WSILRDRGSFDEPTSKFCVACVTEAFDYLHLLGIIYRDLKP 579 Query: 449 DNVVLDVDDEGENGSPRARLADFGSAAWIGA 541 +N++LD D +L DFG A IG+ Sbjct: 580 ENLILDADG-------YLKLVDFGFAKKIGS 603
>KPCD2_HUMAN (Q9BZL6) Serine/threonine-protein kinase D2 (EC 2.7.11.13)| (nPKC-D2) Length = 878 Score = 63.9 bits (154), Expect = 3e-10 Identities = 44/150 (29%), Positives = 72/150 (48%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 FGVV+ R TG AVK +L ++A L + +PG+V + ++E Sbjct: 562 FGVVYGGKHRKTGRDVAVKVIDKLRFPTKQESQLRN---EVAILQSLRHPGIVNLECMFE 618 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 +VM+ G D+L+ + +PE + ++ Q+ AL H + ++H D+KP Sbjct: 619 TPEKVFVVMEKLHG-DMLEMILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKP 677 Query: 449 DNVVLDVDDEGENGSPRARLADFGSAAWIG 538 +NV+L D P+ +L DFG A IG Sbjct: 678 ENVLLASADP----FPQVKLCDFGFARIIG 703
>KS6A1_RAT (Q63531) Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1)| (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A) Length = 735 Score = 63.9 bits (154), Expect = 3e-10 Identities = 44/155 (28%), Positives = 76/155 (49%), Gaps = 1/155 (0%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 + V RC ++T +AVK E+ L +P ++ + VY+ Sbjct: 429 YSVCKRCVHKATNMEYAVKVIDKSKRDPSEEIEIL--------LRYGQHPNIITLKDVYD 480 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 D ++V +L G +LLD ++ R E A+ ++ +++ + H +GV+HRD+KP Sbjct: 481 DSKHVYLVTELMRGGELLD--KILRQKFFSEREASFVLYTISKTVEYLHSQGVVHRDLKP 538 Query: 449 DNVVLDVDDEGENGSPRA-RLADFGSAAWIGADGG 550 N +L VD E+G+P R+ DFG A + A+ G Sbjct: 539 SN-ILYVD---ESGNPECLRICDFGFAKQLRAENG 569 Score = 53.9 bits (128), Expect = 3e-07 Identities = 33/101 (32%), Positives = 55/101 (54%) Frame = +2 Query: 218 LAAAGNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQ 397 LA +P VV++H ++ + ++++D G DL + RL + E +A+LA Sbjct: 116 LADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDL--FTRLSKEVMFTEEDVKFYLAELAL 173 Query: 398 ALALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFG 520 L H G+I+RD+KP+N++L D+EG +L DFG Sbjct: 174 GLDHLHSLGIIYRDLKPENILL--DEEG-----HIKLTDFG 207
>KS6A1_MOUSE (P18653) Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1)| (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A) Length = 724 Score = 63.5 bits (153), Expect = 4e-10 Identities = 44/155 (28%), Positives = 76/155 (49%), Gaps = 1/155 (0%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 + V RC ++T +AVK E+ L +P ++ + VY+ Sbjct: 418 YSVCKRCVHKATNMEYAVKVIDKSKRDPSEEIEIL--------LRYGQHPNIITLKDVYD 469 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 D ++V +L G +LLD ++ R E A+ ++ +++ + H +GV+HRD+KP Sbjct: 470 DGKHVYLVTELMRGGELLD--KILRQKFFSEREASFVLHTISKTVEYLHSQGVVHRDLKP 527 Query: 449 DNVVLDVDDEGENGSPRA-RLADFGSAAWIGADGG 550 N +L VD E+G+P R+ DFG A + A+ G Sbjct: 528 SN-ILYVD---ESGNPECLRICDFGFAKQLRAENG 558 Score = 53.9 bits (128), Expect = 3e-07 Identities = 33/101 (32%), Positives = 55/101 (54%) Frame = +2 Query: 218 LAAAGNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQ 397 LA +P VV++H ++ + ++++D G DL + RL + E +A+LA Sbjct: 116 LADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDL--FTRLSKEVMFTEEDVKFYLAELAL 173 Query: 398 ALALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFG 520 L H G+I+RD+KP+N++L D+EG +L DFG Sbjct: 174 GLDHLHSLGIIYRDLKPENILL--DEEG-----HIKLTDFG 207
>KCC2A_MOUSE (P11798) Calcium/calmodulin-dependent protein kinase type II alpha| chain (EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II alpha subunit) Length = 478 Score = 63.5 bits (153), Expect = 4e-10 Identities = 41/146 (28%), Positives = 73/146 (50%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 F VV RC G+ + K +L E E ++ +L +P +V++H Sbjct: 24 FSVVRRCVKVLAGQEYPAKIINTKKLSARDHQKL-EREARICRLLK--HPNIVRLHDSIS 80 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 ++ +++ DL +G +L + + R E A+ + Q+ +A+ CH+ GV+HRD+KP Sbjct: 81 EEGHHYLIFDLVTGGELFEDIVAREY--YSEADASHCIQQILEAVLHCHQMGVVHRDLKP 138 Query: 449 DNVVLDVDDEGENGSPRARLADFGSA 526 +N++L +G +LADFG A Sbjct: 139 ENLLLASKLKG----AAVKLADFGLA 160
>LATS2_MOUSE (Q7TSJ6) Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Large| tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Kinase phosphorylated during mitosis protein) Length = 1042 Score = 63.5 bits (153), Expect = 4e-10 Identities = 37/112 (33%), Positives = 61/112 (54%) Frame = +2 Query: 185 ELAEIEPKLAQLAAAGNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEP 364 ++A ++ + LA A N VV+++ ++D + VMD G D++ L R PE Sbjct: 667 QVAHVKAERDILAEADNEWVVKLYYSFQDKDSLYFVMDYIPGGDMMSL--LIRMEVFPEH 724 Query: 365 VAADIVAQLAQALALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFG 520 +A +A+L A+ H+ G IHRD+KPDN+++D+D +L DFG Sbjct: 725 LARFYIAELTLAIESVHKMGFIHRDIKPDNILIDLDG-------HIKLTDFG 769
>DAPK3_HUMAN (O43293) Death-associated protein kinase 3 (EC 2.7.11.1) (DAP| kinase 3) (DAP-like kinase) (Dlk) (ZIP-kinase) Length = 454 Score = 63.5 bits (153), Expect = 4e-10 Identities = 40/152 (26%), Positives = 75/152 (49%), Gaps = 1/152 (0%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXX-ELAEIEPKLAQLAAAGNPGVVQVHAVY 265 F +V +C + TG+ +A K EIE ++ L +P ++ +H ++ Sbjct: 24 FAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVNILREIRHPNIITLHDIF 83 Query: 266 EDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVK 445 E+ + ++++L SG +L D++ + + E A + Q+ + H + + H D+K Sbjct: 84 ENKTDVVLILELVSGGELFDFLAEKES--LTEDEATQFLKQILDGVHYLHSKRIAHFDLK 141 Query: 446 PDNVVLDVDDEGENGSPRARLADFGSAAWIGA 541 P+N++L +D N PR +L DFG A I A Sbjct: 142 PENIML-LDKNVPN--PRIKLIDFGIAHKIEA 170
>KS6A_CAEEL (Q21734) Putative ribosomal protein S6 kinase alpha (EC 2.7.11.1)| Length = 784 Score = 63.2 bits (152), Expect = 5e-10 Identities = 47/167 (28%), Positives = 77/167 (46%), Gaps = 1/167 (0%) Frame = +2 Query: 53 DYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAG 232 DY VVH+C ++T +AVK ++ L + Sbjct: 453 DYEILEKIGNGAHSVVHKCQMKATRRKYAVKIVKKAVFDATEEVDIL--------LRHSH 504 Query: 233 NPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALC 412 + VV++ VYED++ +M+ +LC G +LLD + ++ + VAA I+A L A+ Sbjct: 505 HQFVVKLFDVYEDETAIYMIEELCEGGELLDKLVNKKSLGSEKEVAA-IMANLLNAVQYL 563 Query: 413 HRRGVIHRDVKPDNVVLDVDDEGENGSPRA-RLADFGSAAWIGADGG 550 H + V HRD+ N++ + D G P + R+ DFG A A+ G Sbjct: 564 HSQQVAHRDLTAANILFALKD----GDPSSLRIVDFGFAKQSRAENG 606 Score = 54.3 bits (129), Expect = 2e-07 Identities = 35/142 (24%), Positives = 68/142 (47%) Frame = +2 Query: 95 VVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYEDD 274 +V + R +G +A+K + ++E + LA +P +V++H ++ + Sbjct: 120 LVRKVRGRDSGHVYAMKVLKKATLKVRDR-QRTKLERNI--LAHISHPFIVKLHYAFQTE 176 Query: 275 SWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKPDN 454 ++++D G DL + RL + E +A+L AL H G+++RD+KP+N Sbjct: 177 GKLYLILDFLRGGDL--FTRLSKEVMFTEDDVKFYLAELTLALEHLHSLGIVYRDLKPEN 234 Query: 455 VVLDVDDEGENGSPRARLADFG 520 ++LD D ++ DFG Sbjct: 235 ILLDADG-------HIKVTDFG 249
>PHKG1_RABIT (P00518) Phosphorylase b kinase gamma catalytic chain, skeletal| muscle isoform (EC 2.7.11.19) (Phosphorylase kinase gamma subunit 1) Length = 386 Score = 63.2 bits (152), Expect = 5e-10 Identities = 40/147 (27%), Positives = 70/147 (47%), Gaps = 5/147 (3%) Frame = +2 Query: 95 VVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEI-EPKLAQL----AAAGNPGVVQVHA 259 VV RC + T + +AVK E+ E+ E L ++ +G+P ++Q+ Sbjct: 32 VVRRCIHKPTCKEYAVKIIDVTGGGSFSAEEVQELREATLKEVDILRKVSGHPNIIQLKD 91 Query: 260 VYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRD 439 YE +++ +V DL +L D+ L + E I+ L + + H+ ++HRD Sbjct: 92 TYETNTFFFLVFDLMKKGELFDY--LTEKVTLSEKETRKIMRALLEVICALHKLNIVHRD 149 Query: 440 VKPDNVVLDVDDEGENGSPRARLADFG 520 +KP+N++LD D +L DFG Sbjct: 150 LKPENILLDDD-------MNIKLTDFG 169
>CDKL1_HUMAN (Q00532) Cyclin-dependent kinase-like 1 (EC 2.7.11.22)| (Serine/threonine-protein kinase KKIALRE) (Protein kinase p42 KKIALRE) Length = 357 Score = 63.2 bits (152), Expect = 5e-10 Identities = 45/147 (30%), Positives = 66/147 (44%), Gaps = 1/147 (0%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXX-XXXXXELAEIEPKLAQLAAAGNPGVVQVHAVY 265 +GVV +C +R TG+ A+K L EI L +P +V + V+ Sbjct: 15 YGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIR----MLKQLKHPNLVNLLEVF 70 Query: 266 EDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVK 445 H+V + C L + R +RG VPE + I Q QA+ CH+ IHRDVK Sbjct: 71 RRKRRLHLVFEYCDHTVLHELDRYQRG--VPEHLVKSITWQTLQAVNFCHKHNCIHRDVK 128 Query: 446 PDNVVLDVDDEGENGSPRARLADFGSA 526 P+N+++ +L DFG A Sbjct: 129 PENILITKHSV-------IKLCDFGFA 148
>WIN1_SCHPO (O74304) MAP kinase kinase kinase win1 (EC 2.7.11.25)| Length = 1436 Score = 63.2 bits (152), Expect = 5e-10 Identities = 47/151 (31%), Positives = 69/151 (45%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 FG V+R + TG+ AVK + I+ ++ L +P VV + + Sbjct: 1131 FGTVYRAVNLDTGDLMAVKEVALHKPRISRPM-IKRIKGEMLVLELFDHPNVVSYYGIEV 1189 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 ++ M+LC G L ++ LR G E V V QL + LA H GV H+DVKP Sbjct: 1190 HREKVNIFMELCQGSSLFEF--LRYGRIEDELVIQVYVLQLLEGLAYIHSCGVSHQDVKP 1247 Query: 449 DNVVLDVDDEGENGSPRARLADFGSAAWIGA 541 +N++ D NG + DFGSA G+ Sbjct: 1248 ENILFD-----HNGI--MKFTDFGSAKMSGS 1271
>KPCD1_HUMAN (Q15139) Serine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1)| (Protein kinase D) (Protein kinase C mu type) (nPKC-mu) Length = 912 Score = 63.2 bits (152), Expect = 5e-10 Identities = 43/150 (28%), Positives = 71/150 (47%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 FG+V+ R TG A+K +L ++A L +PGVV + ++E Sbjct: 594 FGIVYGGKHRKTGRDVAIKIIDKLRFPTKQESQLRN---EVAILQNLHHPGVVNLECMFE 650 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 +VM+ G D+L+ + +PE + ++ Q+ AL H + ++H D+KP Sbjct: 651 TPERVFVVMEKLHG-DMLEMILSSEKGRLPEHITKFLITQILVALRHLHFKNIVHCDLKP 709 Query: 449 DNVVLDVDDEGENGSPRARLADFGSAAWIG 538 +NV+L D P+ +L DFG A IG Sbjct: 710 ENVLLASADP----FPQVKLCDFGFARIIG 735
>NUAK1_MOUSE (Q641K5) NUAK family, SNF1-like kinase 1 (EC 2.7.11.1)| Length = 658 Score = 62.8 bits (151), Expect = 6e-10 Identities = 38/159 (23%), Positives = 73/159 (45%) Frame = +2 Query: 44 LNRDYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLA 223 L Y +G V R T R +G A+K ++ I ++ ++ Sbjct: 52 LKHRYELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDEL--DMVHIRREIEIMS 109 Query: 224 AAGNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQAL 403 + +P ++ ++ V+E+ ++M+ S +L D++ RR + E Q+ A+ Sbjct: 110 SLNHPHIISIYEVFENKDKIVIIMEYASKGELYDYISERRR--LSERETRHFFRQIVSAV 167 Query: 404 ALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFG 520 CH+ GV+HRD+K +N++LD + ++ADFG Sbjct: 168 HYCHKNGVVHRDLKLENILLD-------DNCNIKIADFG 199
>CDKL1_BRARE (Q6AXJ9) Cyclin-dependent kinase-like 1 (EC 2.7.11.22)| Length = 350 Score = 62.8 bits (151), Expect = 6e-10 Identities = 44/147 (29%), Positives = 67/147 (45%), Gaps = 1/147 (0%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXX-XXXXXELAEIEPKLAQLAAAGNPGVVQVHAVY 265 +GVV +C ++ TG+ A+K L EI L +P +V + V+ Sbjct: 15 YGVVFKCRNKDTGQIVAIKKFVESEDDPIIKKIALREIR----MLKQLKHPNLVNLMEVF 70 Query: 266 EDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVK 445 H+V + C L + R RG VPE + I+ Q QA+ CH++ IHRDVK Sbjct: 71 RRKRKLHLVFEYCDHTVLNELDRYPRG--VPEHMVKSIIWQTLQAVNFCHKQNCIHRDVK 128 Query: 446 PDNVVLDVDDEGENGSPRARLADFGSA 526 P+N+++ +L DFG A Sbjct: 129 PENILITKHQV-------IKLCDFGFA 148
>KS6AA_XENLA (P10665) Ribosomal protein S6 kinase 2 alpha (EC 2.7.11.1)| (Ribosomal protein S6 kinase II alpha) (S6KII-alpha) (P90-RSK) (MAP kinase-activated protein kinase 1) (MAPK-activated protein kinase 1) (MAPKAP kinase 1) (MAPKAPK-1) Length = 733 Score = 62.8 bits (151), Expect = 6e-10 Identities = 46/154 (29%), Positives = 76/154 (49%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 + V RC + T +AVK E EI + Q +P ++ + VY+ Sbjct: 427 YSVCKRCVHKGTNMEYAVKVIDKTKRDPS---EEIEILRRYGQ-----HPNIIALKDVYK 478 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 + + ++V +L G +LLD R+ R E A+ ++ + + + H +GV+HRD+KP Sbjct: 479 EGNSIYVVTELMRGGELLD--RILRQKFFSEREASSVLFTVCKTVENLHSQGVVHRDLKP 536 Query: 449 DNVVLDVDDEGENGSPRARLADFGSAAWIGADGG 550 N +L VD+ G+ S R+ DFG A + AD G Sbjct: 537 SN-ILYVDESGDPES--IRICDFGFAKQLRADNG 567 Score = 53.1 bits (126), Expect = 5e-07 Identities = 33/101 (32%), Positives = 55/101 (54%) Frame = +2 Query: 218 LAAAGNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQ 397 LA +P VV++H ++ + ++++D G DL + RL + E +A+LA Sbjct: 116 LADVHHPFVVRLHYAFQTEGKLYLILDFLRGGDL--FTRLSKEVMFTEEDVKFYLAELAL 173 Query: 398 ALALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFG 520 L H G+I+RD+KP+N++L D+EG +L DFG Sbjct: 174 GLDHLHSLGIIYRDLKPENILL--DEEG-----HIKLTDFG 207
>NUAK1_HUMAN (O60285) NUAK family, SNF1-like kinase 1 (EC 2.7.11.1)| (AMPK-related protein kinase 5) Length = 661 Score = 62.8 bits (151), Expect = 6e-10 Identities = 38/159 (23%), Positives = 73/159 (45%) Frame = +2 Query: 44 LNRDYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLA 223 L Y +G V R T R +G A+K ++ I ++ ++ Sbjct: 51 LKHRYELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDEQ--DMVHIRREIEIMS 108 Query: 224 AAGNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQAL 403 + +P ++ ++ V+E+ ++M+ S +L D++ RR + E Q+ A+ Sbjct: 109 SLNHPHIISIYEVFENKDKIVIIMEYASKGELYDYISERRR--LSERETRHFFRQIVSAV 166 Query: 404 ALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFG 520 CH+ GV+HRD+K +N++LD + ++ADFG Sbjct: 167 HYCHKNGVVHRDLKLENILLD-------DNCNIKIADFG 198
>COT1_NEUCR (P38679) Serine/threonine-protein kinase cot-1 (EC 2.7.11.1)| (Colonial temperature-sensitive 1) Length = 598 Score = 62.8 bits (151), Expect = 6e-10 Identities = 39/144 (27%), Positives = 71/144 (49%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 FG V ++ G+ +A+K +LA + + LA + +P VV+++ ++ Sbjct: 225 FGEVKLVQKKADGKVYAMKSLIKTEMFKKD--QLAHVRAERDILAESDSPWVVKLYTTFQ 282 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 D ++ +M+M+ G DL+ L + E + +A++ A+ H+ G IHRD+KP Sbjct: 283 DANFLYMLMEFLPGGDLM--TMLIKYEIFSEDITRFYIAEIVLAIDAVHKLGFIHRDIKP 340 Query: 449 DNVVLDVDDEGENGSPRARLADFG 520 DN++LD +L DFG Sbjct: 341 DNILLD-------RGGHVKLTDFG 357
>PHKG1_HUMAN (Q16816) Phosphorylase b kinase gamma catalytic chain, skeletal| muscle isoform (EC 2.7.11.19) (Phosphorylase kinase gamma subunit 1) Length = 386 Score = 62.8 bits (151), Expect = 6e-10 Identities = 39/147 (26%), Positives = 70/147 (47%), Gaps = 5/147 (3%) Frame = +2 Query: 95 VVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEI-EPKLAQL----AAAGNPGVVQVHA 259 VV RC + T + +AVK E+ E+ E L ++ +G+P ++Q+ Sbjct: 32 VVRRCIHKPTSQEYAVKVIDVTGGGSFSPEEVRELREATLKEVDILRKVSGHPNIIQLKD 91 Query: 260 VYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRD 439 YE +++ +V DL +L D+ L + E I+ L + + H+ ++HRD Sbjct: 92 TYETNTFFFLVFDLMKRGELFDY--LTEKVTLSEKETRKIMRALLEVICTLHKLNIVHRD 149 Query: 440 VKPDNVVLDVDDEGENGSPRARLADFG 520 +KP+N++LD + +L DFG Sbjct: 150 LKPENILLD-------DNMNIKLTDFG 169
>ZYG1_CAEBR (Q621J7) Probable serine/threonine-protein kinase zyg-1 (EC| 2.7.11.1) (Zygote defective protein 1) Length = 709 Score = 62.4 bits (150), Expect = 8e-10 Identities = 40/153 (26%), Positives = 71/153 (46%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 FGVV+ R GE A+K I+ ++ + + +VQ + + Sbjct: 24 FGVVYSA-QRENGEKVAIKKIGNAASQT-------RIKEEIKTMKLLRHRNIVQFYETFF 75 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 ++ T++VM+LC G L+D+V+ + P+ + A I+ QL A+ H ++HRD+ Sbjct: 76 ENGETYLVMELCEGGSLMDYVKQK--GPLDDSTAVHILRQLIAAVKYIHDENILHRDLSA 133 Query: 449 DNVVLDVDDEGENGSPRARLADFGSAAWIGADG 547 NV + + + +L DFG A +G G Sbjct: 134 GNVFI---KDATKSTITVKLGDFGLATNLGQHG 163
>PHKG1_MOUSE (P07934) Phosphorylase b kinase gamma catalytic chain, skeletal| muscle isoform (EC 2.7.11.19) (Phosphorylase kinase gamma subunit 1) Length = 387 Score = 62.4 bits (150), Expect = 8e-10 Identities = 39/147 (26%), Positives = 70/147 (47%), Gaps = 5/147 (3%) Frame = +2 Query: 95 VVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEI-EPKLAQL----AAAGNPGVVQVHA 259 VV RC + T + +AVK E+ E+ E L ++ +G+P ++Q+ Sbjct: 32 VVRRCIHKPTCQEYAVKIIDITGGGSFSSEEVQELREATLKEVDILQKVSGHPNIIQLKD 91 Query: 260 VYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRD 439 YE +++ +V DL +L D+ L + E I+ L + + H+ ++HRD Sbjct: 92 TYETNTFFFLVFDLMKRGELFDY--LTEKVTLTEKETRKIMRALLEVICTLHKLNIVHRD 149 Query: 440 VKPDNVVLDVDDEGENGSPRARLADFG 520 +KP+N++LD + +L DFG Sbjct: 150 LKPENILLD-------DNMNIKLTDFG 169
>KPCD1_MOUSE (Q62101) Serine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1)| (Protein kinase D) (Protein kinase C mu type) (nPKC-mu) Length = 918 Score = 62.4 bits (150), Expect = 8e-10 Identities = 43/150 (28%), Positives = 71/150 (47%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 FG+V+ R TG A+K +L ++A L +PGVV + ++E Sbjct: 600 FGIVYGGKHRKTGRDVAIKIIDKLRFPTKQESQLRN---EVAILQNLHHPGVVNLECMFE 656 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 +VM+ G D+L+ + +PE + ++ Q+ AL H + ++H D+KP Sbjct: 657 TPERVFVVMEKLHG-DMLEMILSSEKGWLPEHITKFLITQILVALRHLHFKNIVHCDLKP 715 Query: 449 DNVVLDVDDEGENGSPRARLADFGSAAWIG 538 +NV+L D P+ +L DFG A IG Sbjct: 716 ENVLLASADP----FPQVKLCDFGFARIIG 741
>KCC2G_MOUSE (Q923T9) Calcium/calmodulin-dependent protein kinase type II gamma| chain (EC 2.7.11.17) (CaM-kinase II gamma chain) (CaM kinase II gamma subunit) (CaMK-II gamma subunit) Length = 529 Score = 62.4 bits (150), Expect = 8e-10 Identities = 44/173 (25%), Positives = 81/173 (46%), Gaps = 8/173 (4%) Frame = +2 Query: 53 DYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAG 232 DY F VV RC +++ + +A K +L E E ++ +L Sbjct: 13 DYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKL-EREARICRLLK-- 69 Query: 233 NPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALC 412 +P +V++H ++ + ++V DL +G +L + + R E A+ + Q+ +++ Sbjct: 70 HPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREY--YSEADASHCIHQILESVNHI 127 Query: 413 HRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSA--------AWIGADG 547 H+ ++HRD+KP+N++L +G +LADFG A AW G G Sbjct: 128 HQHDIVHRDLKPENLLLASKCKG----AAVKLADFGLAIEVQGEQQAWFGFAG 176
>M3K14_MOUSE (Q9WUL6) Mitogen-activated protein kinase kinase kinase 14 (EC| 2.7.11.25) (NF-kappa beta-inducing kinase) (Serine/threonine-protein kinase NIK) Length = 942 Score = 62.4 bits (150), Expect = 8e-10 Identities = 46/153 (30%), Positives = 68/153 (44%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 FG VHR + TG AVK E+ +E +L A +P +V ++ Sbjct: 413 FGEVHRMKDKQTGFQCAVKKVRL---------EVFRVE-ELVACAGLSSPRIVPLYGAVR 462 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 + W ++ M+L G L ++ + +PE A + Q + L H R ++H DVK Sbjct: 463 EGPWVNIFMELLEGGSLGQLIK--QMGCLPEDRALYYLGQALEGLEYLHTRRILHGDVKA 520 Query: 449 DNVVLDVDDEGENGSPRARLADFGSAAWIGADG 547 DNV+L D RA L DFG A + DG Sbjct: 521 DNVLLSSD------GSRAALCDFGHALCLQPDG 547
>KCC2G_HUMAN (Q13555) Calcium/calmodulin-dependent protein kinase type II gamma| chain (EC 2.7.11.17) (CaM-kinase II gamma chain) (CaM kinase II gamma subunit) (CaMK-II gamma subunit) Length = 558 Score = 62.4 bits (150), Expect = 8e-10 Identities = 44/173 (25%), Positives = 81/173 (46%), Gaps = 8/173 (4%) Frame = +2 Query: 53 DYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAG 232 DY F VV RC +++ + +A K +L E E ++ +L Sbjct: 13 DYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKL-EREARICRLLK-- 69 Query: 233 NPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALC 412 +P +V++H ++ + ++V DL +G +L + + R E A+ + Q+ +++ Sbjct: 70 HPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREY--YSEADASHCIHQILESVNHI 127 Query: 413 HRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSA--------AWIGADG 547 H+ ++HRD+KP+N++L +G +LADFG A AW G G Sbjct: 128 HQHDIVHRDLKPENLLLASKCKG----AAVKLADFGLAIEVQGEQQAWFGFAG 176
>KCC2G_RAT (P11730) Calcium/calmodulin-dependent protein kinase type II gamma| chain (EC 2.7.11.17) (CaM-kinase II gamma chain) (CaM kinase II gamma subunit) (CaMK-II gamma subunit) Length = 527 Score = 62.4 bits (150), Expect = 8e-10 Identities = 44/173 (25%), Positives = 81/173 (46%), Gaps = 8/173 (4%) Frame = +2 Query: 53 DYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAG 232 DY F VV RC +++ + +A K +L E E ++ +L Sbjct: 13 DYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKL-EREARICRLLK-- 69 Query: 233 NPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALC 412 +P +V++H ++ + ++V DL +G +L + + R E A+ + Q+ +++ Sbjct: 70 HPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREY--YSEADASHCIHQILESVNHI 127 Query: 413 HRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSA--------AWIGADG 547 H+ ++HRD+KP+N++L +G +LADFG A AW G G Sbjct: 128 HQHDIVHRDLKPENLLLASKCKG----AAVKLADFGLAIEVQGEQQAWFGFAG 176
>PHKG1_RAT (P13286) Phosphorylase b kinase gamma catalytic chain, skeletal| muscle isoform (EC 2.7.11.19) (Phosphorylase kinase gamma subunit 1) Length = 387 Score = 62.0 bits (149), Expect = 1e-09 Identities = 39/147 (26%), Positives = 70/147 (47%), Gaps = 5/147 (3%) Frame = +2 Query: 95 VVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEI-EPKLAQL----AAAGNPGVVQVHA 259 VV RC + T + +AVK E+ E+ E L ++ +G+P ++Q+ Sbjct: 32 VVRRCIHKPTCQEYAVKIIDITGGGSFSSEEVQELREATLKEVDILQKVSGHPNIIQLKD 91 Query: 260 VYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRD 439 YE +++ +V DL +L D+ L + E I+ L + + H+ ++HRD Sbjct: 92 TYETNTFFFLVFDLMKRGELFDY--LTEKVTLTEKETRKIMRALLEVVCTLHKLNIVHRD 149 Query: 440 VKPDNVVLDVDDEGENGSPRARLADFG 520 +KP+N++LD + +L DFG Sbjct: 150 LKPENILLD-------DNMNIKLTDFG 169
>MRCKB_RAT (Q7TT49) Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1)| (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta) Length = 1713 Score = 62.0 bits (149), Expect = 1e-09 Identities = 36/102 (35%), Positives = 58/102 (56%) Frame = +2 Query: 242 VVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRR 421 + +H ++D+++ ++VMD G DLL + + +PE +A + ++ A+ H+ Sbjct: 136 ITALHYAFQDENYLYLVMDYYVGGDLLTLLS-KFEDKLPEDMARFYIGEMVLAIDSIHQL 194 Query: 422 GVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSAAWIGADG 547 +HRD+KPDNV+LDV NG RLADFGS + DG Sbjct: 195 HYVHRDIKPDNVLLDV-----NG--HIRLADFGSCLKMNDDG 229
>MRCKB_MOUSE (Q7TT50) Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1)| (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta) Length = 1713 Score = 62.0 bits (149), Expect = 1e-09 Identities = 36/102 (35%), Positives = 58/102 (56%) Frame = +2 Query: 242 VVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRR 421 + +H ++D+++ ++VMD G DLL + + +PE +A + ++ A+ H+ Sbjct: 136 ITALHYAFQDENYLYLVMDYYVGGDLLTLLS-KFEDKLPEDMARFYIGEMVLAIDSIHQL 194 Query: 422 GVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSAAWIGADG 547 +HRD+KPDNV+LDV NG RLADFGS + DG Sbjct: 195 HYVHRDIKPDNVLLDV-----NG--HIRLADFGSCLKMNDDG 229
>KPCD3_MOUSE (Q8K1Y2) Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein| kinase C nu type) (nPKC-nu) Length = 889 Score = 62.0 bits (149), Expect = 1e-09 Identities = 42/150 (28%), Positives = 71/150 (47%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 FG+V+ R TG A+K +L ++A L +PG+V + ++E Sbjct: 586 FGIVYGGKHRKTGRDVAIKVIDKMRFPTKQESQLRN---EVAILQNLHHPGIVNLECMFE 642 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 +VM+ G D+L+ + + +PE + +V Q+ AL H + ++H D+KP Sbjct: 643 TPERVFVVMEKLHG-DMLEMILSSEKSRLPERITKFMVTQILVALRNLHFKNIVHCDLKP 701 Query: 449 DNVVLDVDDEGENGSPRARLADFGSAAWIG 538 +NV+L P+ +L DFG A IG Sbjct: 702 ENVLL----ASAEPFPQVKLCDFGFARIIG 727
>KPCD3_HUMAN (O94806) Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein| kinase C nu type) (nPKC-nu) (Protein kinase EPK2) Length = 890 Score = 62.0 bits (149), Expect = 1e-09 Identities = 42/150 (28%), Positives = 71/150 (47%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 FG+V+ R TG A+K +L ++A L +PG+V + ++E Sbjct: 587 FGIVYGGKHRKTGRDVAIKVIDKMRFPTKQESQLRN---EVAILQNLHHPGIVNLECMFE 643 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 +VM+ G D+L+ + + +PE + +V Q+ AL H + ++H D+KP Sbjct: 644 TPERVFVVMEKLHG-DMLEMILSSEKSRLPERITKFMVTQILVALRNLHFKNIVHCDLKP 702 Query: 449 DNVVLDVDDEGENGSPRARLADFGSAAWIG 538 +NV+L P+ +L DFG A IG Sbjct: 703 ENVLL----ASAEPFPQVKLCDFGFARIIG 728
>KS6A6_HUMAN (Q9UK32) Ribosomal protein S6 kinase alpha-6 (EC 2.7.11.1)| (S6K-alpha 6) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4) Length = 745 Score = 62.0 bits (149), Expect = 1e-09 Identities = 42/154 (27%), Positives = 73/154 (47%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 + V RC +T FAVK E+ + +P ++ + V++ Sbjct: 437 YSVCKRCIHATTNMEFAVKIIDKSKRDPSEEIEIL--------MRYGQHPNIITLKDVFD 488 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 D + ++V DL G +LLD R+ + E A+DI+ +++ + H +GV+HRD+KP Sbjct: 489 DGRYVYLVTDLMKGGELLD--RILKQKCFSEREASDILYVISKTVDYLHCQGVVHRDLKP 546 Query: 449 DNVVLDVDDEGENGSPRARLADFGSAAWIGADGG 550 N +L +D+ S R+ DFG A + + G Sbjct: 547 SN-ILYMDESASADS--IRICDFGFAKQLRGENG 577 Score = 50.8 bits (120), Expect = 3e-06 Identities = 30/101 (29%), Positives = 55/101 (54%) Frame = +2 Query: 218 LAAAGNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQ 397 L +P +V++H ++ + ++++D G D+ + RL + E +A+LA Sbjct: 127 LVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDV--FTRLSKEVLFTEEDVKFYLAELAL 184 Query: 398 ALALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFG 520 AL H+ G+++RD+KP+N++LD E G +L DFG Sbjct: 185 ALDHLHQLGIVYRDLKPENILLD-----EIG--HIKLTDFG 218
>LATS2_HUMAN (Q9NRM7) Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Large| tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Kinase phosphorylated during mitosis protein) (Warts-like kinase) Length = 1088 Score = 62.0 bits (149), Expect = 1e-09 Identities = 36/101 (35%), Positives = 55/101 (54%) Frame = +2 Query: 218 LAAAGNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQ 397 LA A N VV+++ ++D + VMD G D++ L R PE +A +A+L Sbjct: 720 LAEADNEWVVKLYYSFQDKDSLYFVMDYIPGGDMMSL--LIRMEVFPEHLARFYIAELTL 777 Query: 398 ALALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFG 520 A+ H+ G IHRD+KPDN+++D+D +L DFG Sbjct: 778 AIESVHKMGFIHRDIKPDNILIDLDG-------HIKLTDFG 811
>KPC2_APLCA (Q16975) Calcium-independent protein kinase C (EC 2.7.11.13) (APL| II) Length = 743 Score = 62.0 bits (149), Expect = 1e-09 Identities = 40/144 (27%), Positives = 68/144 (47%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 FG V + T E +A+K E E ++ L+A +P + +H+ ++ Sbjct: 414 FGKVMLAEKKGTDEVYAIKVLKKDVIIQDDDVECTMTEKRILALSAK-HPFLTALHSSFQ 472 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 VM+ +G DL+ +++R EP A A++ AL HR G+I+RD+K Sbjct: 473 TKERLFFVMEYVNGGDLM--FQIQRARKFDEPRARFYAAEVTLALMFLHRHGIIYRDLKL 530 Query: 449 DNVVLDVDDEGENGSPRARLADFG 520 DN++LD + ++ADFG Sbjct: 531 DNILLDAEG-------HCKIADFG 547
>CBK1_PNECA (Q6TGC6) Serine/threonine-protein kinase CBK1 (EC 2.7.11.1)| Length = 507 Score = 61.6 bits (148), Expect = 1e-09 Identities = 40/156 (25%), Positives = 72/156 (46%) Frame = +2 Query: 53 DYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAG 232 D+ FG V TG+ +A+K +LA ++ + LA + Sbjct: 125 DFHTVKVIGKGAFGEVRLVQKIDTGKIYAMKTLLKSEMFKKD--QLAHVKAERDVLAESD 182 Query: 233 NPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALC 412 +P VV ++ ++D + +++M+ G DL+ L + E V +A+ A+ Sbjct: 183 SPWVVSLYYSFQDSQYLYLIMEFLPGGDLM--TMLIKYDTFSEDVTRFYIAECILAIEAV 240 Query: 413 HRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFG 520 H+ G IHRD+KPDN+++D + +L+DFG Sbjct: 241 HKLGFIHRDIKPDNILID-------KTGHIKLSDFG 269
>PKNE_MYCTU (P72001) Serine/threonine-protein kinase pknE (EC 2.7.11.1)| Length = 566 Score = 61.6 bits (148), Expect = 1e-09 Identities = 39/98 (39%), Positives = 50/98 (51%) Frame = +2 Query: 236 PGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCH 415 P VV +H E D ++ M L +G DL LRR P+ P A IV Q+ AL H Sbjct: 74 PHVVPIHDFGEIDGQLYVDMRLINGVDLA--AMLRRQGPLAPPRAVAIVRQIGSALDAAH 131 Query: 416 RRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSAA 529 G HRDVKP+N+++ DD A L DFG A+ Sbjct: 132 AAGATHRDVKPENILVSADD-------FAYLVDFGIAS 162
>PKNE_MYCBO (Q7TZN3) Serine/threonine-protein kinase pknE (EC 2.7.11.1)| Length = 566 Score = 61.6 bits (148), Expect = 1e-09 Identities = 39/98 (39%), Positives = 50/98 (51%) Frame = +2 Query: 236 PGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCH 415 P VV +H E D ++ M L +G DL LRR P+ P A IV Q+ AL H Sbjct: 74 PHVVPIHDFGEIDGQLYVDMRLINGVDLA--AMLRRQGPLAPPRAVAIVRQIGSALDAAH 131 Query: 416 RRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSAA 529 G HRDVKP+N+++ DD A L DFG A+ Sbjct: 132 AAGATHRDVKPENILVSADD-------FAYLVDFGIAS 162
>KS6AB_XENLA (P10666) Ribosomal protein S6 kinase 2 beta (EC 2.7.11.1)| (Ribosomal protein S6 kinase II beta) (S6KII-beta) (P90-RSK) Length = 629 Score = 61.6 bits (148), Expect = 1e-09 Identities = 45/154 (29%), Positives = 75/154 (48%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 + V RC + T +AVK E EI + Q +P ++ + VYE Sbjct: 427 YSVCKRCVHKGTNMEYAVKVIDKSKRDPS---EEIEILRRYGQ-----HPNIITLKDVYE 478 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 + + ++V +L G +LLD R+ R E A ++ + + + H +GV+HRD+KP Sbjct: 479 ECNSIYLVTELMRGGELLD--RILRQKFFSEREACSVLFTVCKTVEYLHSQGVVHRDLKP 536 Query: 449 DNVVLDVDDEGENGSPRARLADFGSAAWIGADGG 550 N +L VD+ G+ S R+ DFG + + A+ G Sbjct: 537 SN-ILYVDESGDPES--IRICDFGFSKQLRAENG 567 Score = 53.1 bits (126), Expect = 5e-07 Identities = 33/101 (32%), Positives = 55/101 (54%) Frame = +2 Query: 218 LAAAGNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQ 397 LA +P VV++H ++ + ++++D G DL + RL + E +A+LA Sbjct: 116 LADVHHPFVVRLHYAFQTEGKLYLILDFLRGGDL--FTRLSKEVMFTEEDVKFYLAELAL 173 Query: 398 ALALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFG 520 L H G+I+RD+KP+N++L D+EG +L DFG Sbjct: 174 GLDHLHSLGIIYRDLKPENILL--DEEG-----HIKLTDFG 207
>NEK1_MOUSE (P51954) Serine/threonine-protein kinase Nek1 (EC 2.7.11.1)| (NimA-related protein kinase 1) Length = 1203 Score = 61.6 bits (148), Expect = 1e-09 Identities = 37/114 (32%), Positives = 55/114 (48%) Frame = +2 Query: 185 ELAEIEPKLAQLAAAGNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEP 364 E E ++A LA +P +VQ +E++ ++VMD C G DL + ++GA E Sbjct: 44 ERQESRREVAVLANMKHPNIVQYKESFEENGSLYIVMDYCEGGDLFKRINAQKGALFQED 103 Query: 365 VAADIVAQLAQALALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSA 526 D Q+ AL H R ++HRD+K N+ L D +L DFG A Sbjct: 104 QILDWFVQICLALKHVHDRKILHRDIKSQNIFLTKDG-------TVQLGDFGIA 150
>LATS1_HUMAN (O95835) Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large| tumor suppressor homolog 1) (WARTS protein kinase) (h-warts) Length = 1130 Score = 61.6 bits (148), Expect = 1e-09 Identities = 37/112 (33%), Positives = 62/112 (55%) Frame = +2 Query: 185 ELAEIEPKLAQLAAAGNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEP 364 ++A ++ + LA A N VV+++ ++D + VMD G D++ + +R G PE Sbjct: 746 QVAHVKAERDILAEADNEWVVRLYYSFQDKDNLYFVMDYIPGGDMMSLL-IRMGI-FPES 803 Query: 365 VAADIVAQLAQALALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFG 520 +A +A+L A+ H+ G IHRD+KPDN+++D D +L DFG Sbjct: 804 LARFYIAELTCAVESVHKMGFIHRDIKPDNILIDRDG-------HIKLTDFG 848
>CIPK1_ARATH (Q8RWC9) CBL-interacting serine/threonine-protein kinase 1 (EC| 2.7.11.1) (SOS2-like protein kinase PKS13) (SNF1-related kinase 3.16) Length = 444 Score = 61.6 bits (148), Expect = 1e-09 Identities = 46/175 (26%), Positives = 74/175 (42%) Frame = +2 Query: 5 RKPEENH*TMSGELNRDYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXX 184 R+ EE G Y FG V +G +FAVK Sbjct: 3 RRQEEEKKAEKGMRLGKYELGRTLGEGNFGKVKFAKDTVSGHSFAVKIIDKSRIADLNFS 62 Query: 185 ELAEIEPKLAQLAAAGNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEP 364 +I+ ++ L +P +V++H V + +MVM+L +G +L D R+ + E Sbjct: 63 --LQIKREIRTLKMLKHPHIVRLHEVLASKTKINMVMELVTGGELFD--RIVSNGKLTET 118 Query: 365 VAADIVAQLAQALALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSAA 529 + QL ++ CH +GV HRD+K +NV+LD ++ DFG +A Sbjct: 119 DGRKMFQQLIDGISYCHSKGVFHRDLKLENVLLD-------AKGHIKITDFGLSA 166
>KOK0_YEAST (Q12236) Probable serine/threonine-protein kinase YOL100W (EC| 2.7.11.1) Length = 1081 Score = 61.6 bits (148), Expect = 1e-09 Identities = 40/159 (25%), Positives = 71/159 (44%) Frame = +2 Query: 50 RDYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAA 229 +D+ + V TS T + +A K + IE K A Sbjct: 177 KDFKFGSVIGDGAYSTVMLATSIDTKKRYAAKVLNKEYLIRQKKVKYVSIE-KTALQKLN 235 Query: 230 GNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALAL 409 +P VV++ + ++D+S + +++ D L +++ + E A AQ+ A+ Sbjct: 236 NSPSVVRLFSTFQDESSLYFLLEYAPNGDFLSL--MKKYGSLDETCARYYAAQIIDAIDY 293 Query: 410 CHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSA 526 H G+IHRD+KP+N++LD G + +L DFG+A Sbjct: 294 LHSNGIIHRDIKPENILLD-------GEMKIKLTDFGTA 325
>KCC1D_MOUSE (Q8BW96) Calcium/calmodulin-dependent protein kinase type 1D (EC| 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK) (mCKLiK) Length = 385 Score = 61.2 bits (147), Expect = 2e-09 Identities = 41/144 (28%), Positives = 70/144 (48%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 F V ++TG+ FAVK + IE ++A L + +V + +YE Sbjct: 34 FSEVVLAEEKATGKLFAVKCIPKKALKGKE----SSIENEIAVLRKIKHENIVALEDIYE 89 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 + ++VM L SG +L D R+ E A+ ++ Q+ A+ HR G++HRD+KP Sbjct: 90 SPNHLYLVMQLVSGGELFD--RIVEKGFYTEKDASTLIRQVLDAVYYLHRMGIVHRDLKP 147 Query: 449 DNVVLDVDDEGENGSPRARLADFG 520 +N++ DE + ++DFG Sbjct: 148 ENLLYYSQDE----ESKIMISDFG 167
>KCC1D_HUMAN (Q8IU85) Calcium/calmodulin-dependent protein kinase type 1D (EC| 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK) Length = 385 Score = 61.2 bits (147), Expect = 2e-09 Identities = 41/144 (28%), Positives = 70/144 (48%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 F V ++TG+ FAVK + IE ++A L + +V + +YE Sbjct: 34 FSEVVLAEEKATGKLFAVKCIPKKALKGKE----SSIENEIAVLRKIKHENIVALEDIYE 89 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 + ++VM L SG +L D R+ E A+ ++ Q+ A+ HR G++HRD+KP Sbjct: 90 SPNHLYLVMQLVSGGELFD--RIVEKGFYTEKDASTLIRQVLDAVYYLHRMGIVHRDLKP 147 Query: 449 DNVVLDVDDEGENGSPRARLADFG 520 +N++ DE + ++DFG Sbjct: 148 ENLLYYSQDE----ESKIMISDFG 167
>DAPK1_MOUSE (Q80YE7) Death-associated protein kinase 1 (EC 2.7.11.1) (DAP| kinase 1) Length = 1442 Score = 61.2 bits (147), Expect = 2e-09 Identities = 39/147 (26%), Positives = 72/147 (48%), Gaps = 1/147 (0%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAE-IEPKLAQLAAAGNPGVVQVHAVY 265 F VV +C +STG +A K E IE +++ L +P V+ +H VY Sbjct: 24 FAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILKEIRHPNVITLHEVY 83 Query: 266 EDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVK 445 E+ + ++++L +G +L D++ + + E A + + Q+ + H + H D+K Sbjct: 84 ENKTDVILILELVAGGELFDFLAEKES--LTEEEATEFLKQILSGVYYLHSLQIAHFDLK 141 Query: 446 PDNVVLDVDDEGENGSPRARLADFGSA 526 P+N++L + PR ++ DFG A Sbjct: 142 PENIML---LDRNVPKPRIKIIDFGLA 165
>KS6A1_HUMAN (Q15418) Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1)| (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A) Length = 735 Score = 61.2 bits (147), Expect = 2e-09 Identities = 43/150 (28%), Positives = 73/150 (48%), Gaps = 1/150 (0%) Frame = +2 Query: 104 RCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYEDDSWT 283 RC ++T +AVK E+ L +P ++ + VY+D Sbjct: 434 RCVHKATNMEYAVKVIDKSKRDPSEEIEIL--------LRYGQHPNIITLKDVYDDGKHV 485 Query: 284 HMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKPDNVVL 463 ++V +L G +LLD ++ R E A+ ++ + + + H +GV+HRD+KP N +L Sbjct: 486 YLVTELMRGGELLD--KILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHRDLKPSN-IL 542 Query: 464 DVDDEGENGSPRA-RLADFGSAAWIGADGG 550 VD E+G+P R+ DFG A + A+ G Sbjct: 543 YVD---ESGNPECLRICDFGFAKQLRAENG 569 Score = 53.9 bits (128), Expect = 3e-07 Identities = 33/101 (32%), Positives = 55/101 (54%) Frame = +2 Query: 218 LAAAGNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQ 397 LA +P VV++H ++ + ++++D G DL + RL + E +A+LA Sbjct: 116 LADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDL--FTRLSKEVMFTEEDVKFYLAELAL 173 Query: 398 ALALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFG 520 L H G+I+RD+KP+N++L D+EG +L DFG Sbjct: 174 GLDHLHSLGIIYRDLKPENILL--DEEG-----HIKLTDFG 207
>KPC2_DROME (P13677) Protein kinase C, eye isozyme (EC 2.7.11.13) (PKC)| (dPKC53E(EY)) (Protein INAC) (Inactivation no after-potential C protein) (Photoreceptor-specific PKC) (Eye-PKC) Length = 700 Score = 61.2 bits (147), Expect = 2e-09 Identities = 46/145 (31%), Positives = 67/145 (46%), Gaps = 1/145 (0%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPG-VVQVHAVY 265 FG V R T E +AVK EL E K+ LA +G P +V +H+ + Sbjct: 382 FGKVLLAERRGTDELYAVKVLRKDVIIQTDDMELPMNEKKI--LALSGRPPFLVSMHSCF 439 Query: 266 EDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVK 445 + VM+ C G DL+ +++ E VA ++A AL H R +I+RD+K Sbjct: 440 QTMDRLFFVMEYCKGGDLM--YHMQQYGRFKESVAIFYAVEVAIALFFLHERDIIYRDLK 497 Query: 446 PDNVVLDVDDEGENGSPRARLADFG 520 DN++LD G +L DFG Sbjct: 498 LDNILLD-------GEGHVKLVDFG 515
>DAPK1_HUMAN (P53355) Death-associated protein kinase 1 (EC 2.7.11.1) (DAP| kinase 1) Length = 1432 Score = 61.2 bits (147), Expect = 2e-09 Identities = 39/147 (26%), Positives = 72/147 (48%), Gaps = 1/147 (0%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAE-IEPKLAQLAAAGNPGVVQVHAVY 265 F VV +C +STG +A K E IE +++ L +P V+ +H VY Sbjct: 24 FAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILKEIQHPNVITLHEVY 83 Query: 266 EDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVK 445 E+ + ++++L +G +L D++ + + E A + + Q+ + H + H D+K Sbjct: 84 ENKTDVILILELVAGGELFDFLAEKES--LTEEEATEFLKQILNGVYYLHSLQIAHFDLK 141 Query: 446 PDNVVLDVDDEGENGSPRARLADFGSA 526 P+N++L + PR ++ DFG A Sbjct: 142 PENIML---LDRNVPKPRIKIIDFGLA 165
>LATS1_MOUSE (Q8BYR2) Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large| tumor suppressor homolog 1) (WARTS protein kinase) Length = 1129 Score = 61.2 bits (147), Expect = 2e-09 Identities = 37/112 (33%), Positives = 62/112 (55%) Frame = +2 Query: 185 ELAEIEPKLAQLAAAGNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEP 364 ++A ++ + LA A N VV+++ ++D + VMD G D++ + +R G PE Sbjct: 745 QVAHVKAERDILAEADNEWVVRLYYSFQDKDNLYFVMDYIPGGDMMSLL-IRMGI-FPEN 802 Query: 365 VAADIVAQLAQALALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFG 520 +A +A+L A+ H+ G IHRD+KPDN+++D D +L DFG Sbjct: 803 LARFYIAELTCAVESVHKMGFIHRDIKPDNILIDRDG-------HIKLTDFG 847
>KPC1_DROME (P05130) Protein kinase C, brain isozyme (EC 2.7.11.13) (PKC)| (dPKC53E(BR)) Length = 679 Score = 61.2 bits (147), Expect = 2e-09 Identities = 41/144 (28%), Positives = 69/144 (47%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 FG V + + E +A+K E IE ++ L P +VQ+H+ ++ Sbjct: 361 FGKVLLAERKGSEELYAIKILKKDVIIQDDDVECTMIEKRVLALGEKP-PFLVQLHSCFQ 419 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 VM+ +G DL+ ++++ EPVA A++A L H +G+++RD+K Sbjct: 420 TMDRLFFVMEYVNGGDLM--FQIQQFGKFKEPVAVFYAAEIAAGLFFLHTKGILYRDLKL 477 Query: 449 DNVVLDVDDEGENGSPRARLADFG 520 DNV+LD D ++ADFG Sbjct: 478 DNVLLDADG-------HVKIADFG 494
>KAPB_YEAST (P06245) cAMP-dependent protein kinase type 2 (EC 2.7.11.11) (PKA| 2) Length = 380 Score = 60.8 bits (146), Expect = 2e-09 Identities = 44/158 (27%), Positives = 69/158 (43%) Frame = +2 Query: 53 DYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAG 232 D+ FG VH S G +A+K E E ++ +L Sbjct: 69 DFQIMRTLGTGSFGRVHLVRSVHNGRYYAIKVLKKQQVVKMKQVEHTNDERRMLKLVE-- 126 Query: 233 NPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALC 412 +P ++++ ++D MVMD G +L LR+ P PVA A++ AL Sbjct: 127 HPFLIRMWGTFQDARNIFMVMDYIEGGELFSL--LRKSQRFPNPVAKFYAAEVILALEYL 184 Query: 413 HRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSA 526 H +I+RD+KP+N++LD NG ++ DFG A Sbjct: 185 HAHNIIYRDLKPENILLD-----RNG--HIKITDFGFA 215
>DAPK2_MOUSE (Q8VDF3) Death-associated protein kinase 2 (EC 2.7.11.1) (DAP| kinase 2) (DAP-kinase-related protein 1) (DRP-1) Length = 370 Score = 60.8 bits (146), Expect = 2e-09 Identities = 39/147 (26%), Positives = 71/147 (48%), Gaps = 1/147 (0%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAE-IEPKLAQLAAAGNPGVVQVHAVY 265 F +V +C +STG +A K E IE +++ L +P ++ +H VY Sbjct: 34 FAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVCREEIEREVSILRQVLHPNIITLHDVY 93 Query: 266 EDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVK 445 E+ + ++++L SG +L D+ L + + E A + Q+ + H + + H D+K Sbjct: 94 ENRTDVVLILELVSGGELFDF--LAQKESLSEEEATSFIKQILDGVNYLHTKKIAHFDLK 151 Query: 446 PDNVVLDVDDEGENGSPRARLADFGSA 526 P+N++L + P +L DFG A Sbjct: 152 PENIML---LDKNIPIPHIKLIDFGLA 175
>DCAK2_HUMAN (Q8N568) Serine/threonine-protein kinase DCAMKL2 (EC 2.7.11.1)| (Doublecortin-like and CAM kinase-like 2) Length = 766 Score = 60.8 bits (146), Expect = 2e-09 Identities = 47/169 (27%), Positives = 73/169 (43%) Frame = +2 Query: 20 NH*TMSGELNRDYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEI 199 N + S L Y F VV C RSTG+ FA+K I Sbjct: 382 NRCSESSTLLEKYKIGKVIGDGNFAVVKECIDRSTGKEFALKIIDKAKCCGKEHL----I 437 Query: 200 EPKLAQLAAAGNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADI 379 E +++ L +P ++ + E + +VM+L G DL D + E + + Sbjct: 438 ENEVSILRRVKHPNIIMLVEEMETATELFLVMELVKGGDLFD--AITSSTKYTERDGSAM 495 Query: 380 VAQLAQALALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSA 526 V LA AL H ++HRD+KP+N+++ E +G+ +L DFG A Sbjct: 496 VYNLANALRYLHGLSIVHRDIKPENLLV---CEYPDGTKSLKLGDFGLA 541
>LOK_DROME (O61267) Ovarian-specific serine/threonine-protein kinase Lok (EC| 2.7.11.1) (Protein loki) (dMNK) Length = 476 Score = 60.5 bits (145), Expect = 3e-09 Identities = 43/172 (25%), Positives = 78/172 (45%), Gaps = 4/172 (2%) Frame = +2 Query: 41 ELNRDYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKXXXXXXXXXXX-XXELAEIEPKLAQ 217 E+N+ Y +G+V T + FA+K ++ + L + Sbjct: 169 EINKTYYVNRKLGSGAYGLVRLVYDTRTCQQFAMKIVKKNMLSGARPSTNFSDPDRVLNE 228 Query: 218 LAAAGN---PGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQ 388 N P VV++H + + +MV++ G DLL+ R+ + E ++ Q Sbjct: 229 AKIMKNLSHPCVVRMHDIVDKPDSVYMVLEFMRGGDLLN--RIISNKLLSEDISKLYFYQ 286 Query: 389 LAQALALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSAAWIGAD 544 + A+ H RG+ HRD+KPDNV+L+ +DE +++DFG + ++ D Sbjct: 287 MCHAVKYLHDRGITHRDLKPDNVLLETNDE----ETLLKVSDFGLSKFVQKD 334
>CPK11_ARATH (O22932) CBL-interacting serine/threonine-protein kinase 11 (EC| 2.7.11.1) (SOS2-like protein kinase PKS5) (SOS-interacting protein 4) (SNF1-related kinase 3.22) Length = 435 Score = 60.5 bits (145), Expect = 3e-09 Identities = 40/147 (27%), Positives = 71/147 (48%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 F V R TG++ AVK I+ +++ + +P +V++H V Sbjct: 32 FAKVFHARDRRTGQSVAVKILNKKKLLTNPALA-NNIKREISIMRRLSHPNIVKLHEVMA 90 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 S M+ G +L + ++ + + E ++ QL A+ CH RGV HRD+KP Sbjct: 91 TKSKIFFAMEFVKGGELFN--KISKHGRLSEDLSRRYFQQLISAVGYCHARGVYHRDLKP 148 Query: 449 DNVVLDVDDEGENGSPRARLADFGSAA 529 +N+++D ENG+ +++DFG +A Sbjct: 149 ENLLID-----ENGN--LKVSDFGLSA 168
>CBK1_YARLI (Q6CFS5) Serine/threonine-protein kinase CBK1 (EC 2.7.11.1)| Length = 588 Score = 60.5 bits (145), Expect = 3e-09 Identities = 38/156 (24%), Positives = 72/156 (46%) Frame = +2 Query: 53 DYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAG 232 D+ FG V R G+ +A+K + A ++ + LA + Sbjct: 206 DFVTVKVIGKGAFGEVRLVQKRDNGKIYAMKTMLKKEMDMKE--QWAHVKAERDVLADSD 263 Query: 233 NPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALC 412 +P +V ++ ++DD + +++M+ G DL+ L + E + +A+ A+ Sbjct: 264 SPWIVSLYFSFQDDLYLYLIMEFLPGGDLM--TMLIKYDVFSEDITRFYIAECVLAIEAI 321 Query: 413 HRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFG 520 H+ G IHRD+KPDN+++D + +L+DFG Sbjct: 322 HKLGFIHRDIKPDNILID-------KTGHIKLSDFG 350
>KCC4_RAT (P13234) Calcium/calmodulin-dependent protein kinase type IV (EC| 2.7.11.17) (CAM kinase-GR) (CaMK IV) (Calspermin) Length = 474 Score = 60.5 bits (145), Expect = 3e-09 Identities = 38/144 (26%), Positives = 71/144 (49%), Gaps = 2/144 (1%) Frame = +2 Query: 95 VVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYEDD 274 +V+RC + T + +A+K E+ L +P ++++ ++E Sbjct: 55 IVYRCKQKGTQKPYALKVLKKTVDKKIVRTEIGV-------LLRLSHPNIIKLKEIFETP 107 Query: 275 SWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKPDN 454 + +V++L +G +L D R+ E AAD V Q+ +A+A H G++HRD+KP+N Sbjct: 108 TEISLVLELVTGGELFD--RIVEKGYYSERDAADAVKQILEAVAYLHENGIVHRDLKPEN 165 Query: 455 VVLDVDDEGENGSPRA--RLADFG 520 ++ +P A ++ADFG Sbjct: 166 LLY------ATPAPDAPLKIADFG 183
>CDPK1_PLAYO (Q7RAH3) Calcium-dependent protein kinase 1 (EC 2.7.11.1)| Length = 534 Score = 60.5 bits (145), Expect = 3e-09 Identities = 30/117 (25%), Positives = 64/117 (54%) Frame = +2 Query: 194 EIEPKLAQLAAAGNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAA 373 EI +++ L + +P ++++ V+ED + ++V + G +L + + R E AA Sbjct: 110 EIYNEISLLKSLDHPNIIKLFDVFEDKKYFYLVTEFYEGGELFEQIINRH--KFDECDAA 167 Query: 374 DIVAQLAQALALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSAAWIGAD 544 +I+ Q+ + H+ ++HRD+KP+N++L E +N ++ DFG +++ D Sbjct: 168 NIMKQILSGICYLHKHNIVHRDIKPENILL----ENKNSLLNIKIVDFGLSSFFSKD 220
>PKNH_MYCTU (Q11053) Probable serine/threonine-protein kinase pknH (EC| 2.7.11.1) Length = 626 Score = 60.5 bits (145), Expect = 3e-09 Identities = 41/98 (41%), Positives = 52/98 (53%) Frame = +2 Query: 236 PGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCH 415 P VV +H E D + M L G DL D V L+R P+ P A I+ Q+A AL H Sbjct: 74 PHVVPIHDYGEVDGQMFLEMRLVEGTDL-DSV-LKRFGPLTPPRAVAIITQIASALDAAH 131 Query: 416 RRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSAA 529 GV+HRDVKP N+++ DD A L DFG A+ Sbjct: 132 ADGVMHRDVKPQNILITRDD-------FAYLVDFGIAS 162
>MRCKB_HUMAN (Q9Y5S2) Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1)| (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta) Length = 1711 Score = 60.5 bits (145), Expect = 3e-09 Identities = 36/102 (35%), Positives = 57/102 (55%) Frame = +2 Query: 242 VVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRR 421 + +H ++D++ ++VMD G DLL + + +PE +A + ++ A+ H+ Sbjct: 136 ITALHYAFQDENHLYLVMDYYVGGDLLTLLS-KFEDKLPEDMARFYIGEMVLAIDSIHQL 194 Query: 422 GVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSAAWIGADG 547 +HRD+KPDNV+LDV NG RLADFGS + DG Sbjct: 195 HYVHRDIKPDNVLLDV-----NG--HIRLADFGSCLKMNDDG 229
>NEK1_HUMAN (Q96PY6) Serine/threonine-protein kinase Nek1 (EC 2.7.11.1)| (NimA-related protein kinase 1) (NY-REN-55 antigen) Length = 1258 Score = 60.5 bits (145), Expect = 3e-09 Identities = 36/114 (31%), Positives = 54/114 (47%) Frame = +2 Query: 185 ELAEIEPKLAQLAAAGNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEP 364 E E ++A LA +P +VQ +E++ ++VMD C G DL + ++G E Sbjct: 44 EREESRREVAVLANMKHPNIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQED 103 Query: 365 VAADIVAQLAQALALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSA 526 D Q+ AL H R ++HRD+K N+ L D +L DFG A Sbjct: 104 QILDWFVQICLALKHVHDRKILHRDIKSQNIFLTKDG-------TVQLGDFGIA 150
>PKNH_MYCBO (Q7U095) Probable serine/threonine-protein kinase pknH (EC| 2.7.11.1) Length = 596 Score = 60.5 bits (145), Expect = 3e-09 Identities = 41/98 (41%), Positives = 52/98 (53%) Frame = +2 Query: 236 PGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCH 415 P VV +H E D + M L G DL D V L+R P+ P A I+ Q+A AL H Sbjct: 74 PHVVPIHDYGEVDGQMFLEMRLVEGTDL-DSV-LKRFGPLTPPRAVAIITQIASALDAAH 131 Query: 416 RRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSAA 529 GV+HRDVKP N+++ DD A L DFG A+ Sbjct: 132 ADGVMHRDVKPQNILITRDD-------FAYLVDFGIAS 162
>KCC4_HUMAN (Q16566) Calcium/calmodulin-dependent protein kinase type IV (EC| 2.7.11.17) (CAM kinase-GR) (CaMK IV) Length = 473 Score = 60.5 bits (145), Expect = 3e-09 Identities = 38/144 (26%), Positives = 71/144 (49%), Gaps = 2/144 (1%) Frame = +2 Query: 95 VVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYEDD 274 +V+RC + T + +A+K E+ L +P ++++ ++E Sbjct: 59 IVYRCKQKGTQKPYALKVLKKTVDKKIVRTEIGV-------LLRLSHPNIIKLKEIFETP 111 Query: 275 SWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKPDN 454 + +V++L +G +L D R+ E AAD V Q+ +A+A H G++HRD+KP+N Sbjct: 112 TEISLVLELVTGGELFD--RIVEKGYYSERDAADAVKQILEAVAYLHENGIVHRDLKPEN 169 Query: 455 VVLDVDDEGENGSPRA--RLADFG 520 ++ +P A ++ADFG Sbjct: 170 LLY------ATPAPDAPLKIADFG 187
>KPCZ_RABIT (O19111) Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta)| Length = 591 Score = 60.5 bits (145), Expect = 3e-09 Identities = 38/135 (28%), Positives = 68/135 (50%) Frame = +2 Query: 116 RSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYEDDSWTHMVM 295 + G+ +A+K + + E + + A+GNP +V +H+ ++ S +V+ Sbjct: 271 KKNGQVYAMKVVKKELVHDDEDIDWVQTEKHVFE-QASGNPFLVGLHSCFQTTSRLFLVI 329 Query: 296 DLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKPDNVVLDVDD 475 + +G DL+ ++R +PE A A++ AL H RG+I+RD+K DNV+LD D Sbjct: 330 EYVNGGDLM--FHMQRQRKLPEEHARFYAAEICIALNFLHERGIIYRDLKLDNVLLDADG 387 Query: 476 EGENGSPRARLADFG 520 +L D+G Sbjct: 388 -------HIKLTDYG 395
>ULK1_HUMAN (O75385) Serine/threonine-protein kinase ULK1 (EC 2.7.11.1)| (Unc-51-like kinase 1) Length = 1050 Score = 60.1 bits (144), Expect = 4e-09 Identities = 33/101 (32%), Positives = 58/101 (57%), Gaps = 3/101 (2%) Frame = +2 Query: 242 VVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRR 421 +V ++ E + ++VM+ C+G DL D++ R + E + Q+A A+ L H + Sbjct: 75 IVALYDFQEMANSVYLVMEYCNGGDLADYLHAMR--TLSEDTIRLFLQQIAGAMRLLHSK 132 Query: 422 GVIHRDVKPDNVVLDVDDEGENGSP---RARLADFGSAAWI 535 G+IHRD+KP N++L + G +P R ++ADFG A ++ Sbjct: 133 GIIHRDLKPQNILLS-NPAGRRANPNSIRVKIADFGFARYL 172
>PK1_STRTO (Q9KIG4) Serine/threonine-protein kinase PK-1 (EC 2.7.11.1)| (stoPK-1) Length = 641 Score = 60.1 bits (144), Expect = 4e-09 Identities = 38/101 (37%), Positives = 58/101 (57%) Frame = +2 Query: 218 LAAAGNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQ 397 +A +P VVQV D ++ ++ M+ +G L D +R RGA P A DI+ + Sbjct: 70 VARLAHPNVVQVFDQGTDGAYVYLAMEYIAGCTLRDVLR-ERGALQPR-AALDILEPVLA 127 Query: 398 ALALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFG 520 AL HR G +HRD+KP+NV++ G++G R ++ADFG Sbjct: 128 ALGAAHRAGFVHRDMKPENVLI-----GDDG--RVKVADFG 161
>KPC1B_CAEEL (P34885) Protein kinase C-like 1B (EC 2.7.11.13) (PKC1B)| Length = 707 Score = 60.1 bits (144), Expect = 4e-09 Identities = 43/156 (27%), Positives = 68/156 (43%) Frame = +2 Query: 53 DYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAG 232 D+ FG V + T E +A+K E E ++ LAA Sbjct: 377 DFTFMKVLGKGSFGKVMLAERKGTDEVYAIKILKKDVIVQDDDVECTMCEKRILSLAAK- 435 Query: 233 NPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALC 412 +P + +H+ ++ VM+ +G DL+ +++R E A A++ AL Sbjct: 436 HPFLTALHSSFQTSDRLFFVMEYVNGGDLM--FQIQRARKFDESRARFYAAEVTCALQFL 493 Query: 413 HRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFG 520 HR VI+RD+K DN++LD + RLADFG Sbjct: 494 HRNDVIYRDLKLDNILLDAEG-------HCRLADFG 522
>ULK1_MOUSE (O70405) Serine/threonine-protein kinase ULK1 (EC 2.7.11.1)| (Unc-51-like kinase 1) (Serine/threonine-protein kinase Unc51.1) Length = 1051 Score = 60.1 bits (144), Expect = 4e-09 Identities = 33/101 (32%), Positives = 58/101 (57%), Gaps = 3/101 (2%) Frame = +2 Query: 242 VVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRR 421 +V ++ E + ++VM+ C+G DL D++ R + E + Q+A A+ L H + Sbjct: 75 IVALYDFQEMANSVYLVMEYCNGGDLADYLHTMR--TLSEDTVRLFLQQIAGAMRLLHSK 132 Query: 422 GVIHRDVKPDNVVLDVDDEGENGSP---RARLADFGSAAWI 535 G+IHRD+KP N++L + G +P R ++ADFG A ++ Sbjct: 133 GIIHRDLKPQNILLS-NPGGRRANPSNIRVKIADFGFARYL 172
>MRCKA_HUMAN (Q5VT25) Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1)| (CDC42-binding protein kinase alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (Myotonic dystrophy protein kinase-like alpha) (MRCK alpha) (DMPK-like alpha Length = 1732 Score = 60.1 bits (144), Expect = 4e-09 Identities = 37/110 (33%), Positives = 59/110 (53%) Frame = +2 Query: 218 LAAAGNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQ 397 L N + +H ++DD+ ++VMD G DLL + +PE +A +A++ Sbjct: 129 LVNGDNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDR-LPEDMARFYLAEMVI 187 Query: 398 ALALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSAAWIGADG 547 A+ H+ +HRD+KPDN+++D+ NG RLADFGS + DG Sbjct: 188 AIDSVHQLHYVHRDIKPDNILMDM-----NG--HIRLADFGSCLKLMEDG 230
>E2AK2_MOUSE (Q03963) Interferon-induced, double-stranded RNA-activated protein| kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase) (Serine/threonine-protein Length = 515 Score = 59.7 bits (143), Expect = 5e-09 Identities = 45/194 (23%), Positives = 77/194 (39%), Gaps = 16/194 (8%) Frame = +2 Query: 14 EENH*TMSGELNRDYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELA 193 + N T+ N D+ FG V + R G+ +A+K Sbjct: 228 QRNKYTLDARFNSDFEDIEEIGLGGFGQVFKAKHRIDGKRYAIKRVKYNTE--------- 278 Query: 194 EIEPKLAQLAAAGNPGVVQVHAVYEDDSWT----------------HMVMDLCSGPDLLD 325 + E ++ LA + +VQ H+ +E + + M+ C L Sbjct: 279 KAEHEVQALAELNHVNIVQYHSCWEGVDYDPEHSMSDTSRYKTRCLFIQMEFCDKGTLEQ 338 Query: 326 WVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRAR 505 W+R R + V + + D+ Q+ + H +G+IHRD+KP N+ L VD+ + Sbjct: 339 WMRNRNQSKVDKALILDLYEQIVTGVEYIHSKGLIHRDLKPGNIFL-VDER------HIK 391 Query: 506 LADFGSAAWIGADG 547 + DFG A + DG Sbjct: 392 IGDFGLATALENDG 405
>KPCA_RAT (P05696) Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha)| (PKC-A) Length = 671 Score = 59.7 bits (143), Expect = 5e-09 Identities = 47/174 (27%), Positives = 78/174 (44%), Gaps = 4/174 (2%) Frame = +2 Query: 11 PEENH*TMSGELNR----DYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKXXXXXXXXXXX 178 P E+ S L+R D+ FG V + T E +A+K Sbjct: 319 PSEDRKQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDD 378 Query: 179 XXELAEIEPKLAQLAAAGNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVP 358 E +E ++ L P + Q+H+ ++ + VM+ +G DL+ +++ Sbjct: 379 DVECTMVEKRVLALLDKP-PFLTQLHSCFQTVDRLYFVMEYVNGGDLM--YHIQQVGKFK 435 Query: 359 EPVAADIVAQLAQALALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFG 520 EP A A+++ L H+RG+I+RD+K DNV+L D EG ++ADFG Sbjct: 436 EPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVML--DSEG-----HIKIADFG 482
>KPCA_RABIT (P10102) Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha)| (PKC-A) Length = 671 Score = 59.7 bits (143), Expect = 5e-09 Identities = 47/174 (27%), Positives = 78/174 (44%), Gaps = 4/174 (2%) Frame = +2 Query: 11 PEENH*TMSGELNR----DYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKXXXXXXXXXXX 178 P E+ S L+R D+ FG V + T E +A+K Sbjct: 319 PSEDRKQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDD 378 Query: 179 XXELAEIEPKLAQLAAAGNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVP 358 E +E ++ L P + Q+H+ ++ + VM+ +G DL+ +++ Sbjct: 379 DVECTMVEKRVLALMDKP-PFLTQLHSCFQTVDRLYFVMEYVNGGDLM--YHIQQVGKFK 435 Query: 359 EPVAADIVAQLAQALALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFG 520 EP A A+++ L H+RG+I+RD+K DNV+L D EG ++ADFG Sbjct: 436 EPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVML--DSEG-----HIKIADFG 482
>KPCA_HUMAN (P17252) Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha)| (PKC-A) Length = 671 Score = 59.7 bits (143), Expect = 5e-09 Identities = 47/174 (27%), Positives = 78/174 (44%), Gaps = 4/174 (2%) Frame = +2 Query: 11 PEENH*TMSGELNR----DYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKXXXXXXXXXXX 178 P E+ S L+R D+ FG V + T E +A+K Sbjct: 319 PSEDRKQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDD 378 Query: 179 XXELAEIEPKLAQLAAAGNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVP 358 E +E ++ L P + Q+H+ ++ + VM+ +G DL+ +++ Sbjct: 379 DVECTMVEKRVLALLDKP-PFLTQLHSCFQTVDRLYFVMEYVNGGDLM--YHIQQVGKFK 435 Query: 359 EPVAADIVAQLAQALALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFG 520 EP A A+++ L H+RG+I+RD+K DNV+L D EG ++ADFG Sbjct: 436 EPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVML--DSEG-----HIKIADFG 482
>KPCA_BOVIN (P04409) Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha)| (PKC-A) Length = 671 Score = 59.7 bits (143), Expect = 5e-09 Identities = 47/174 (27%), Positives = 78/174 (44%), Gaps = 4/174 (2%) Frame = +2 Query: 11 PEENH*TMSGELNR----DYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKXXXXXXXXXXX 178 P E+ S L+R D+ FG V + T E +A+K Sbjct: 319 PSEDRRQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDD 378 Query: 179 XXELAEIEPKLAQLAAAGNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVP 358 E +E ++ L P + Q+H+ ++ + VM+ +G DL+ +++ Sbjct: 379 DVECTMVEKRVLALLDKP-PFLTQLHSCFQTVDRLYFVMEYVNGGDLM--YHIQQVGKFK 435 Query: 359 EPVAADIVAQLAQALALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFG 520 EP A A+++ L H+RG+I+RD+K DNV+L D EG ++ADFG Sbjct: 436 EPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVML--DSEG-----HIKIADFG 482
>KSG1_SCHPO (Q12701) Serine/threonine-protein kinase ksg1 (EC 2.7.11.1)| Length = 592 Score = 59.7 bits (143), Expect = 5e-09 Identities = 42/157 (26%), Positives = 71/157 (45%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 + V T ST +A+K + IE K A + +PG +++ ++ Sbjct: 110 YSTVLTATENSTKREYAIKVLDKRHIIKEKKEKYVNIE-KEALCILSKHPGFIKLFYTFQ 168 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 D + V+ L +LLD++ + E A A + ++ H RGVIHRD+KP Sbjct: 169 DAHNLYFVLSLARNGELLDYIN--KLGRFNEICAQYYAALIVDSIDYMHGRGVIHRDLKP 226 Query: 449 DNVVLDVDDEGENGSPRARLADFGSAAWIGADGGRAE 559 +N++LD + R ++ DFGSA + + G E Sbjct: 227 ENILLD-------DNMRTKITDFGSAKILNSSHGSHE 256
>KOIA_SCHPO (Q9Y7J6) Putative serine/threonine-protein kinase C1778.10c (EC| 2.7.11.1) Length = 550 Score = 59.7 bits (143), Expect = 5e-09 Identities = 37/158 (23%), Positives = 72/158 (45%) Frame = +2 Query: 53 DYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAG 232 DY F V R T + + + +A+K + IE + + + G Sbjct: 53 DYVFGDIIGDGSFSKVRRATDKKSWKEYAIKVLDKKYIVKENKVKYVNIE-RDSMMRLNG 111 Query: 233 NPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALC 412 PG+ ++ ++DD + V++L +LL +++ R + E A++ ++ Sbjct: 112 FPGISRLFHTFQDDLKLYYVLELAPNGELLQYIKKYRF--LDENCVRFYAAEILSSIEYM 169 Query: 413 HRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSA 526 H G+IHRD+KP+N++ D G+ ++ DFG+A Sbjct: 170 HSCGIIHRDLKPENILFD-------GNMHVKITDFGTA 200
>SNRK_HUMAN (Q9NRH2) SNF-related serine/threonine-protein kinase (EC 2.7.11.1)| (SNF1-related kinase) Length = 765 Score = 59.3 bits (142), Expect = 7e-09 Identities = 38/144 (26%), Positives = 71/144 (49%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 F VV TGE AVK L + ++ + +P +V+++ V + Sbjct: 27 FAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQ---EVRCMKLVQHPNIVRLYEVID 83 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 + +++++L G D+ D++ ++ + E +A AQ+ A++ CH+ V+HRD+KP Sbjct: 84 TQTKLYLILELGDGGDMFDYI-MKHEEGLNEDLAKKYFAQIVHAISYCHKLHVVHRDLKP 142 Query: 449 DNVVLDVDDEGENGSPRARLADFG 520 +NVV + +G +L DFG Sbjct: 143 ENVVF-FEKQG-----LVKLTDFG 160
>SNRK_MOUSE (Q8VDU5) SNF-related serine/threonine-protein kinase (EC 2.7.11.1)| (SNF1-related kinase) Length = 748 Score = 59.3 bits (142), Expect = 7e-09 Identities = 38/144 (26%), Positives = 71/144 (49%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 F VV TGE AVK L + ++ + +P +V+++ V + Sbjct: 27 FAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQ---EVRCMKLVQHPNIVRLYEVID 83 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 + +++++L G D+ D++ ++ + E +A AQ+ A++ CH+ V+HRD+KP Sbjct: 84 TQTKLYLILELGDGGDMFDYI-MKHEEGLNEDLAKKYFAQIVHAISYCHKLHVVHRDLKP 142 Query: 449 DNVVLDVDDEGENGSPRARLADFG 520 +NVV + +G +L DFG Sbjct: 143 ENVVF-FEKQG-----LVKLTDFG 160
>AAPK2_RAT (Q09137) 5'-AMP-activated protein kinase catalytic subunit alpha-2| (EC 2.7.11.1) (AMPK alpha-2 chain) Length = 552 Score = 59.3 bits (142), Expect = 7e-09 Identities = 42/144 (29%), Positives = 69/144 (47%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 FG V + TG AVK + +I+ ++ L +P +++++ V Sbjct: 27 FGKVKIGEHQLTGHKVAVKILNRQKIRSLDV--VGKIKREIQNLKLFRHPHIIKLYQVIS 84 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 + MVM+ SG +L D++ + V E A + Q+ A+ CHR V+HRD+KP Sbjct: 85 TPTDFFMVMEYVSGGELFDYIC--KHGRVEEVEARRLFQQILSAVDYCHRHMVVHRDLKP 142 Query: 449 DNVVLDVDDEGENGSPRARLADFG 520 +NV+LD A++ADFG Sbjct: 143 ENVLLD-------AQMNAKIADFG 159
>AAPK2_PIG (Q28948) 5'-AMP-activated protein kinase catalytic subunit alpha-2| (EC 2.7.11.1) (AMPK alpha-2 chain) Length = 552 Score = 59.3 bits (142), Expect = 7e-09 Identities = 42/144 (29%), Positives = 69/144 (47%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 FG V + TG AVK + +I+ ++ L +P +++++ V Sbjct: 27 FGKVKIGEHQLTGHKVAVKILNRQKIRSLDV--VGKIKREIQNLKLFRHPHIIKLYQVIS 84 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 + MVM+ SG +L D++ + V E A + Q+ A+ CHR V+HRD+KP Sbjct: 85 TPTDFFMVMEYVSGGELFDYIC--KHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKP 142 Query: 449 DNVVLDVDDEGENGSPRARLADFG 520 +NV+LD A++ADFG Sbjct: 143 ENVLLD-------AQMNAKIADFG 159
>NEK3_MOUSE (Q9R0A5) Serine/threonine-protein kinase Nek3 (EC 2.7.11.1)| (NimA-related protein kinase 3) Length = 511 Score = 59.3 bits (142), Expect = 7e-09 Identities = 40/146 (27%), Positives = 66/146 (45%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 FG S+ + FA+K + A + LA +P +V +E Sbjct: 15 FGRALLVLQESSNQTFAMKEIRLLKSDTQTSRKEAVL------LAKMKHPNIVAFKESFE 68 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 + + ++VM+ C G DL+ ++ ++G PE + Q+ + H+R V+HRD+K Sbjct: 69 AEGYLYIVMEYCDGGDLMQRIKQQKGNLFPEDTILNWFIQICLGVNHIHKRRVLHRDIKS 128 Query: 449 DNVVLDVDDEGENGSPRARLADFGSA 526 NV L NG + +L DFGSA Sbjct: 129 KNVFLT-----HNG--KVKLGDFGSA 147
>CDK2_MESAU (P48963) Cell division protein kinase 2 (EC 2.7.11.22)| Length = 298 Score = 59.3 bits (142), Expect = 7e-09 Identities = 40/150 (26%), Positives = 69/150 (46%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 +GVV++ ++ TGE A+K +++ L +P +V++ V Sbjct: 15 YGVVYKAKNKLTGEVVALKKIRLDTETEGVPSTAIR---EISLLKELNHPNIVKLLDVIH 71 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 ++ ++V +L DL ++ +P P+ + QL Q LA CH V+HRD+KP Sbjct: 72 TENKLYLVFELLH-QDLKKFMDASAVTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKP 130 Query: 449 DNVVLDVDDEGENGSPRARLADFGSAAWIG 538 N+++ N +LADFG A G Sbjct: 131 QNLLI-------NAEGSIKLADFGLARAFG 153
>CDK2_CARAU (P43450) Cell division protein kinase 2 (EC 2.7.11.22)| Length = 298 Score = 59.3 bits (142), Expect = 7e-09 Identities = 39/150 (26%), Positives = 69/150 (46%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 +GVV++ ++ TGE A+K +++ L +P +V++H V Sbjct: 15 YGVVYKAKNKVTGETVALKKIRLDTETEGVPSTAIR---EISLLKELNHPNIVKLHDVIH 71 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 ++ ++V + DL ++ + P+ + QL Q LA CH V+HRD+KP Sbjct: 72 TENKLYLVFEFLH-QDLKRFMDSSTVTGISLPLVKSYLFQLLQGLAFCHSHRVLHRDLKP 130 Query: 449 DNVVLDVDDEGENGSPRARLADFGSAAWIG 538 N++++ E +LADFG A G Sbjct: 131 QNLLINAQGE-------IKLADFGLARAFG 153
>SNRK_RAT (Q63553) SNF-related serine/threonine-protein kinase (EC 2.7.11.1)| (SNF1-related kinase) Length = 746 Score = 59.3 bits (142), Expect = 7e-09 Identities = 38/144 (26%), Positives = 71/144 (49%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 F VV TGE AVK L + ++ + +P +V+++ V + Sbjct: 27 FAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQ---EVRCMKLVQHPNIVRLYEVID 83 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 + +++++L G D+ D++ ++ + E +A AQ+ A++ CH+ V+HRD+KP Sbjct: 84 TQTKLYLILELGDGGDMFDYI-MKHEEGLNEDLAKKYFAQIVHAISYCHKLHVVHRDLKP 142 Query: 449 DNVVLDVDDEGENGSPRARLADFG 520 +NVV + +G +L DFG Sbjct: 143 ENVVF-FEKQG-----LVKLTDFG 160
>KGP1_DROME (Q03042) cGMP-dependent protein kinase, isozyme 1 (EC 2.7.11.12)| (CGK) Length = 768 Score = 59.3 bits (142), Expect = 7e-09 Identities = 31/107 (28%), Positives = 59/107 (55%) Frame = +2 Query: 218 LAAAGNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQ 397 + ++ +P + +++ + D+ + +M+++ C G ++ W LR + A I+ + Q Sbjct: 511 MLSSRSPFICRLYRTFRDEKYVYMLLEACMGGEI--WTMLRDRGSFEDNAAQFIIGCVLQ 568 Query: 398 ALALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSAAWIG 538 A H RG+I+RD+KP+N++LD E G ++ DFG A IG Sbjct: 569 AFEYLHARGIIYRDLKPENLMLD-----ERG--YVKIVDFGFAKQIG 608
>CHK1_SCHPO (P34208) Serine/threonine-protein kinase chk1 (EC 2.7.11.1)| (Checkpoint kinase 1) Length = 496 Score = 59.3 bits (142), Expect = 7e-09 Identities = 32/106 (30%), Positives = 56/106 (52%) Frame = +2 Query: 230 GNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALAL 409 G+ ++ + E+ W +V++ G DL D ++ + E VA AQL + ++ Sbjct: 70 GHKNIIHFYNTAENPQWRWVVLEFAQGGDLFD--KIEPDVGIDEDVAQFYFAQLMEGISF 127 Query: 410 CHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSAAWIGADG 547 H +GV HRD+KP+N++LD NG+ +++DFG A+ G Sbjct: 128 MHSKGVAHRDLKPENILLDY-----NGN--LKISDFGFASLFSYKG 166
>NRC2_NEUCR (O42626) Serine/threonine-protein kinase nrc-2 (EC 2.7.11.1)| (Nonrepressible conidiation protein 2) Length = 623 Score = 58.9 bits (141), Expect = 9e-09 Identities = 32/124 (25%), Positives = 63/124 (50%) Frame = +2 Query: 92 GVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYED 271 G V+ + +G +A+K + A E ++ LA + +P +V ++ ++ Sbjct: 254 GKVYLVKEKKSGRLYAMKVLSKKEMIKRNKIKRALAEQEI--LATSNHPFIVTLYHSFQS 311 Query: 272 DSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKPD 451 + + ++ M+ CSG + ++ R G +PE A A++ AL H G I+RD+KP+ Sbjct: 312 EDYLYLCMEYCSGGEFFRALQTRPGKCIPEDDARFYAAEVTAALEYLHLMGFIYRDLKPE 371 Query: 452 NVVL 463 N++L Sbjct: 372 NILL 375
>ARK1_SCHPO (O59790) Serine/threonine-protein kinase ark1 (EC 2.7.11.1)| (Aurora-related kinase 1) Length = 355 Score = 58.9 bits (141), Expect = 9e-09 Identities = 37/144 (25%), Positives = 70/144 (48%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 FG V+ + TG A+K + E ++ N +++++ + Sbjct: 100 FGRVYLAKEKKTGFIVALKTLHKSELVQSKIEKQVRREIEIQSNLRHKN--ILRLYGHFH 157 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 D+ +++++ +L + LRR E VA+ + Q+A AL+ H++ VIHRD+KP Sbjct: 158 DEKRIYLILEFAGRGEL--YQHLRRAKRFSEEVASKYIFQMANALSYLHKKHVIHRDIKP 215 Query: 449 DNVVLDVDDEGENGSPRARLADFG 520 +N++L +D E +L+DFG Sbjct: 216 ENILLGIDGE-------IKLSDFG 232
>AAPK2_PONPY (Q5RD00) 5'-AMP-activated protein kinase catalytic subunit alpha-2| (EC 2.7.11.1) (AMPK alpha-2 chain) Length = 552 Score = 58.9 bits (141), Expect = 9e-09 Identities = 42/144 (29%), Positives = 69/144 (47%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 FG V + TG AVK + +I+ ++ L +P +++++ V Sbjct: 27 FGKVKIGEHQLTGHKVAVKILNRQKIRSLDV--VGKIKREIQNLKLFRHPHIIKLYQVIS 84 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 + MVM+ SG +L D++ + V E A + Q+ A+ CHR V+HRD+KP Sbjct: 85 TPTDFFMVMEYVSGGELFDYIC--KHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKP 142 Query: 449 DNVVLDVDDEGENGSPRARLADFG 520 +NV+LD A++ADFG Sbjct: 143 ENVLLD-------AHMNAKIADFG 159
>AAPK2_HUMAN (P54646) 5'-AMP-activated protein kinase catalytic subunit alpha-2| (EC 2.7.11.1) (AMPK alpha-2 chain) Length = 552 Score = 58.9 bits (141), Expect = 9e-09 Identities = 42/144 (29%), Positives = 69/144 (47%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 FG V + TG AVK + +I+ ++ L +P +++++ V Sbjct: 27 FGKVKIGEHQLTGHKVAVKILNRQKIRSLDV--VGKIKREIQNLKLFRHPHIIKLYQVIS 84 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 + MVM+ SG +L D++ + V E A + Q+ A+ CHR V+HRD+KP Sbjct: 85 TPTDFFMVMEYVSGGELFDYIC--KHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKP 142 Query: 449 DNVVLDVDDEGENGSPRARLADFG 520 +NV+LD A++ADFG Sbjct: 143 ENVLLD-------AHMNAKIADFG 159
>ST17A_HUMAN (Q9UEE5) Serine/threonine-protein kinase 17A (EC 2.7.11.1) (DAP| kinase-related apoptosis-inducing protein kinase 1) Length = 414 Score = 58.9 bits (141), Expect = 9e-09 Identities = 39/144 (27%), Positives = 66/144 (45%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 F VV +C + +G+ FA K E+ E + +LA NP V+ +H VYE Sbjct: 72 FAVVRKCIKKDSGKEFAAKFMRKRRKGQDCRMEIIH-EIAVLELAQ-DNPWVINLHEVYE 129 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 S +V++ +G ++ D R E ++ Q+ + + H R V+H D+KP Sbjct: 130 TASEMILVLEYAAGGEIFDQCVADREEAFKEKDVQRLMRQILEGVHFLHTRDVVHLDLKP 189 Query: 449 DNVVLDVDDEGENGSPRARLADFG 520 N++L E+ ++ DFG Sbjct: 190 QNILL----TSESPLGDIKIVDFG 209
>CDK2_ENTHI (Q04770) Cell division protein kinase 2 homolog (EC 2.7.11.22)| Length = 291 Score = 58.9 bits (141), Expect = 9e-09 Identities = 33/107 (30%), Positives = 60/107 (56%) Frame = +2 Query: 206 KLAQLAAAGNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVA 385 ++A L +P VV ++ +Y +D + ++V + C DL + + R + +P IV Sbjct: 51 EIAVLLELKHPNVVDLYDIYLEDKFLYLVFEFCD-EDLYQF--MSRSSKIPINETRSIVY 107 Query: 386 QLAQALALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSA 526 Q+ Q LA CH ++HRD+KP N++++ +NG+ +L +FG A Sbjct: 108 QILQGLAFCHYHQILHRDMKPQNILIN-----KNGT--IKLGEFGLA 147
>M3K14_HUMAN (Q99558) Mitogen-activated protein kinase kinase kinase 14 (EC| 2.7.11.25) (NF-kappa beta-inducing kinase) (Serine/threonine-protein kinase NIK) (HsNIK) Length = 947 Score = 58.9 bits (141), Expect = 9e-09 Identities = 47/153 (30%), Positives = 67/153 (43%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 FG VHR + TG AVK E+ E +A A +P +V ++ Sbjct: 411 FGEVHRMEDKQTGFQCAVKKVRL---------EVFRAEELMA-CAGLTSPRIVPLYGAVR 460 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 + W ++ M+L G L V+ +G +PE A + Q + L H R ++H DVK Sbjct: 461 EGPWVNIFMELLEGGSLGQLVK-EQGC-LPEDRALYYLGQALEGLEYLHSRRILHGDVKA 518 Query: 449 DNVVLDVDDEGENGSPRARLADFGSAAWIGADG 547 DNV+L D A L DFG A + DG Sbjct: 519 DNVLLSSD------GSHAALCDFGHAVCLQPDG 545
>KCC2_YEAST (P22517) Calcium/calmodulin-dependent protein kinase II (EC| 2.7.11.17) Length = 447 Score = 58.9 bits (141), Expect = 9e-09 Identities = 48/158 (30%), Positives = 74/158 (46%) Frame = +2 Query: 53 DYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAG 232 +Y FGVV + ST E A+K +L + +L+ L Sbjct: 46 NYIFGRTLGAGSFGVVRQARKLSTNEDVAIKILLKKALQGNNV-QLQMLYEELSILQKLS 104 Query: 233 NPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALC 412 +P +V +E ++V L +G +L D + L RG E A +I+ Q+ A+ Sbjct: 105 HPNIVSFKDWFESKDKFYIVTQLATGGELFDRI-LSRGK-FTEVDAVEIIVQILGAVEYM 162 Query: 413 HRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSA 526 H + V+HRD+KP+NV+ D+ EN SP +ADFG A Sbjct: 163 HSKNVVHRDLKPENVL--YVDKSEN-SPLV-IADFGIA 196
>PKH3_YEAST (Q03306) Serine/threonine-protein kinase PKH3 (EC 2.7.11.1)| (Pkb-activating kinase homolog 3) Length = 898 Score = 58.9 bits (141), Expect = 9e-09 Identities = 40/141 (28%), Positives = 64/141 (45%), Gaps = 1/141 (0%) Frame = +2 Query: 116 RSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGN-PGVVQVHAVYEDDSWTHMV 292 +S + +A+K + IE L A + G+++++ + D+ + V Sbjct: 32 KSPNKIYAIKVCSKKHIIKEAKVKYVTIEKNTMNLLAQKHHAGIIKLYYTFHDEENLYFV 91 Query: 293 MDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKPDNVVLDVD 472 +D G +LL L + + AQL AL H G+IHRD+KP+NV+LD D Sbjct: 92 LDFAPGGELLSL--LHKMGTFNDIWTRHFTAQLIDALEFIHSHGIIHRDLKPENVLLDRD 149 Query: 473 DEGENGSPRARLADFGSAAWI 535 R + DFG+AA I Sbjct: 150 G-------RLMITDFGAAATI 163
>KPK7_ARATH (Q05999) Putative serine/threonine-protein kinase PK7 (EC 2.7.11.1)| Length = 578 Score = 58.5 bits (140), Expect = 1e-08 Identities = 38/141 (26%), Positives = 67/141 (47%) Frame = +2 Query: 50 RDYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAA 229 +D+ G V+ TG +FAVK A+ E ++ Q + Sbjct: 180 KDFKLIKKLGGGDIGNVYLAELIGTGVSFAVKVMEKAAIAARKKLVRAQTEKEILQ--SL 237 Query: 230 GNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALAL 409 +P + +++ +E + + +VM+ C G DL + +RG PE A VA++ A+ Sbjct: 238 DHPFLPTLYSHFETEMNSCLVMEFCPGGDLHSLRQKQRGKYFPEQAARFYVAEVLLAMEY 297 Query: 410 CHRRGVIHRDVKPDNVVLDVD 472 H G+I+RD+KP+NV++ D Sbjct: 298 LHMLGIIYRDLKPENVLVRED 318
>SSK2_YEAST (P53599) MAP kinase kinase kinase SSK2 (EC 2.7.11.25) (Suppressor of| sensor kinase 2) Length = 1579 Score = 58.5 bits (140), Expect = 1e-08 Identities = 45/155 (29%), Positives = 65/155 (41%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 FG V+ GE AVK I+ +++ L +P +V + V Sbjct: 1277 FGRVYSAVDLDNGEILAVKEINIQDSKSMQKI-FPLIKEEMSVLEILNHPNIVSYYGVEV 1335 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 ++ M+ C G L L G E V QL + LA H G++HRDVKP Sbjct: 1336 HRDKVNIFMEYCEGGSLA--ALLEHGRIEDEMVTQVYTLQLLEGLAYLHESGIVHRDVKP 1393 Query: 449 DNVVLDVDDEGENGSPRARLADFGSAAWIGADGGR 553 +N++LD NG + DFG+A I +G R Sbjct: 1394 ENILLDF-----NGV--IKYVDFGAAKKIANNGTR 1421
>KCC1G_RAT (Q7TNJ7) Calcium/calmodulin-dependent protein kinase type 1G (EC| 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM-KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III) Length = 476 Score = 58.5 bits (140), Expect = 1e-08 Identities = 40/144 (27%), Positives = 70/144 (48%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 F V R TG+ FA+K + +E ++A L + +V + +YE Sbjct: 34 FSEVFLVKQRVTGKLFALKCIKKSPAFRD-----SSLENEIAVLKRIKHENIVTLEDIYE 88 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 + ++VM L SG +L D + L RG E A+ ++ Q+ A+ H G++HRD+KP Sbjct: 89 STTHYYLVMQLVSGGELFDRI-LERGV-YTEKDASLVIQQVLSAVKYLHENGIVHRDLKP 146 Query: 449 DNVVLDVDDEGENGSPRARLADFG 520 +N++ +E + + + DFG Sbjct: 147 ENLLYLTPEE----NSKIMITDFG 166
>KCC1G_HUMAN (Q96NX5) Calcium/calmodulin-dependent protein kinase type 1G (EC| 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM-KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III) Length = 476 Score = 58.5 bits (140), Expect = 1e-08 Identities = 40/144 (27%), Positives = 70/144 (48%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 F V R TG+ FA+K + +E ++A L + +V + +YE Sbjct: 34 FSEVFLVKQRLTGKLFALKCIKKSPAFRD-----SSLENEIAVLKKIKHENIVTLEDIYE 88 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 + ++VM L SG +L D + L RG E A+ ++ Q+ A+ H G++HRD+KP Sbjct: 89 STTHYYLVMQLVSGGELFDRI-LERGV-YTEKDASLVIQQVLSAVKYLHENGIVHRDLKP 146 Query: 449 DNVVLDVDDEGENGSPRARLADFG 520 +N++ +E + + + DFG Sbjct: 147 ENLLYLTPEE----NSKIMITDFG 166
>KPCG_BOVIN (P05128) Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma)| (Fragment) Length = 682 Score = 58.5 bits (140), Expect = 1e-08 Identities = 40/160 (25%), Positives = 70/160 (43%), Gaps = 4/160 (2%) Frame = +2 Query: 53 DYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAG 232 D+ FG V R + E +A+K + +E ++ L G Sbjct: 335 DFSFLMVLGKGSFGKVMLAERRGSDELYAIKILKKDVIVQDDDVDCTLVEKRVLALGGRG 394 Query: 233 NPG----VVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQA 400 G + Q+H+ ++ + VM+ +G DL+ +++ EP AA A++A Sbjct: 395 PGGRPHFLTQLHSTFQTPDRLYFVMEYVTGGDLM--YHIQQLGKFKEPHAAFYAAEIAIG 452 Query: 401 LALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFG 520 L H +G+I+RD+K DNV+LD + ++ DFG Sbjct: 453 LFFLHNQGIIYRDLKLDNVMLDAEG-------HIKITDFG 485
>DCAK2_MOUSE (Q6PGN3) Serine/threonine-protein kinase DCAMKL2 (EC 2.7.11.1)| (Doublecortin-like and CAM kinase-like 2) Length = 756 Score = 58.5 bits (140), Expect = 1e-08 Identities = 42/146 (28%), Positives = 67/146 (45%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 F VV C R TG+ FA+K IE +++ L +P ++ + E Sbjct: 404 FAVVKECVDRYTGKEFALKIIDKAKCCGKEHL----IENEVSILRRVKHPNIIMLVEEME 459 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 + +VM+L G DL D + E + +V LA AL H ++HRD+KP Sbjct: 460 TATDLFLVMELVKGGDLFD--AITSSTKYTERDGSAMVYNLANALRYLHSLSIVHRDIKP 517 Query: 449 DNVVLDVDDEGENGSPRARLADFGSA 526 +N+++ E +G+ +L DFG A Sbjct: 518 ENLLV---CEYPDGTKSLKLGDFGLA 540
>CTRO_MOUSE (P49025) Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK)| (Rho-interacting, serine/threonine-protein kinase 21) Length = 2055 Score = 58.5 bits (140), Expect = 1e-08 Identities = 41/160 (25%), Positives = 73/160 (45%) Frame = +2 Query: 50 RDYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAA 229 RD+ F V ++TG+ +A+K E E + L+ + Sbjct: 95 RDFEVRSLVGCGHFAEVQVVREKATGDVYAMKIMKKKALLAQEQVSFFEEERNI--LSRS 152 Query: 230 GNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALAL 409 +P + Q+ ++D + ++VM+ G D L + R + E + +A+L A+ Sbjct: 153 TSPWIPQLQYAFQDKNNLYLVMEYQPGGDFLSLLN-RYEDQLDESMIQFYLAELILAVHS 211 Query: 410 CHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSAA 529 H+ G +HRD+KP+N+++D E +L DFGSAA Sbjct: 212 VHQMGYVHRDIKPENILIDRTGE-------IKLVDFGSAA 244
>KPCG_RAT (P63319) Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma)| Length = 697 Score = 58.5 bits (140), Expect = 1e-08 Identities = 40/160 (25%), Positives = 70/160 (43%), Gaps = 4/160 (2%) Frame = +2 Query: 53 DYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAG 232 D+ FG V R + E +A+K + +E ++ L G Sbjct: 350 DFSFLMVLGKGSFGKVMLAERRGSDELYAIKILKKDVIVQDDDVDCTLVEKRVLALGGRG 409 Query: 233 NPG----VVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQA 400 G + Q+H+ ++ + VM+ +G DL+ +++ EP AA A++A Sbjct: 410 PGGRPHFLTQLHSTFQTPDRLYFVMEYVTGGDLM--YHIQQLGKFKEPHAAFYAAEIAIG 467 Query: 401 LALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFG 520 L H +G+I+RD+K DNV+LD + ++ DFG Sbjct: 468 LFFLHNQGIIYRDLKLDNVMLDAEG-------HIKITDFG 500
>KPCG_RABIT (P10829) Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma)| (PKC-delta) Length = 697 Score = 58.5 bits (140), Expect = 1e-08 Identities = 40/160 (25%), Positives = 70/160 (43%), Gaps = 4/160 (2%) Frame = +2 Query: 53 DYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAG 232 D+ FG V R + E +A+K + +E ++ L G Sbjct: 350 DFSFLMVLGKGSFGKVMLAERRGSDELYAIKILKKDVIVQDDDVDCTLVEKRVLALGGRG 409 Query: 233 NPG----VVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQA 400 G + Q+H+ ++ + VM+ +G DL+ +++ EP AA A++A Sbjct: 410 PGGRPHFLTQLHSTFQTPDRLYFVMEYVTGGDLM--YHIQQLGKFKEPHAAFYAAEIAIG 467 Query: 401 LALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFG 520 L H +G+I+RD+K DNV+LD + ++ DFG Sbjct: 468 LFFLHNQGIIYRDLKLDNVMLDAEG-------HIKITDFG 500
>KPCG_MOUSE (P63318) Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma)| Length = 697 Score = 58.5 bits (140), Expect = 1e-08 Identities = 40/160 (25%), Positives = 70/160 (43%), Gaps = 4/160 (2%) Frame = +2 Query: 53 DYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAG 232 D+ FG V R + E +A+K + +E ++ L G Sbjct: 350 DFSFLMVLGKGSFGKVMLAERRGSDELYAIKILKKDVIVQDDDVDCTLVEKRVLALGGRG 409 Query: 233 NPG----VVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQA 400 G + Q+H+ ++ + VM+ +G DL+ +++ EP AA A++A Sbjct: 410 PGGRPHFLTQLHSTFQTPDRLYFVMEYVTGGDLM--YHIQQLGKFKEPHAAFYAAEIAIG 467 Query: 401 LALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFG 520 L H +G+I+RD+K DNV+LD + ++ DFG Sbjct: 468 LFFLHNQGIIYRDLKLDNVMLDAEG-------HIKITDFG 500
>KPCG_HUMAN (P05129) Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma)| Length = 697 Score = 58.5 bits (140), Expect = 1e-08 Identities = 40/160 (25%), Positives = 70/160 (43%), Gaps = 4/160 (2%) Frame = +2 Query: 53 DYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAG 232 D+ FG V R + E +A+K + +E ++ L G Sbjct: 350 DFSFLMVLGKGSFGKVMLAERRGSDELYAIKILKKDVIVQDDDVDCTLVEKRVLALGGRG 409 Query: 233 NPG----VVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQA 400 G + Q+H+ ++ + VM+ +G DL+ +++ EP AA A++A Sbjct: 410 PGGRPHFLTQLHSTFQTPDRLYFVMEYVTGGDLM--YHIQQLGKFKEPHAAFYAAEIAIG 467 Query: 401 LALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFG 520 L H +G+I+RD+K DNV+LD + ++ DFG Sbjct: 468 LFFLHNQGIIYRDLKLDNVMLDAEG-------HIKITDFG 500
>KCC1G_MOUSE (Q91VB2) Calcium/calmodulin-dependent protein kinase type 1G (EC| 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM-KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III) Length = 477 Score = 58.5 bits (140), Expect = 1e-08 Identities = 40/144 (27%), Positives = 70/144 (48%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 F V R TG+ FA+K + +E ++A L + +V + +YE Sbjct: 34 FSEVFLVKQRVTGKLFALKCIKKSPAFRD-----SSLENEIAVLKRIKHENIVTLEDIYE 88 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 + ++VM L SG +L D + L RG E A+ ++ Q+ A+ H G++HRD+KP Sbjct: 89 STTHYYLVMQLVSGGELFDRI-LERGV-YTEKDASLVIQQVLSAVKYLHENGIVHRDLKP 146 Query: 449 DNVVLDVDDEGENGSPRARLADFG 520 +N++ +E + + + DFG Sbjct: 147 ENLLYLTPEE----NSKIMITDFG 166
>MRCKA_RAT (O54874) Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1)| (CDC42-binding protein kinase alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (Myotonic dystrophy protein kinase-like alpha) (MRCK alpha) Length = 1732 Score = 58.5 bits (140), Expect = 1e-08 Identities = 35/102 (34%), Positives = 57/102 (55%) Frame = +2 Query: 242 VVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRR 421 + +H ++DD+ ++VMD G DLL + +PE +A +A++ A+ H+ Sbjct: 137 ITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDR-LPEEMARFYLAEMVIAIDSVHQL 195 Query: 422 GVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSAAWIGADG 547 +HRD+KPDN+++D+ NG RLADFGS + DG Sbjct: 196 HYVHRDIKPDNILMDM-----NG--HIRLADFGSCLKLMEDG 230
>KCC4_MOUSE (P08414) Calcium/calmodulin-dependent protein kinase type IV (EC| 2.7.11.17) (CAM kinase-GR) (CaMK IV) Length = 469 Score = 58.5 bits (140), Expect = 1e-08 Identities = 37/144 (25%), Positives = 70/144 (48%), Gaps = 2/144 (1%) Frame = +2 Query: 95 VVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYEDD 274 +V+RC + T + +A+K E+ L +P ++++ ++E Sbjct: 55 IVYRCKQKGTQKPYALKVLKKTVDKKIVRTEIGV-------LLRLSHPNIIKLKEIFETP 107 Query: 275 SWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKPDN 454 + +V++L +G +L D R+ E A D V Q+ +A+A H G++HRD+KP+N Sbjct: 108 TEISLVLELVTGGELFD--RIVEKGYYSERDARDAVKQILEAVAYLHENGIVHRDLKPEN 165 Query: 455 VVLDVDDEGENGSPRA--RLADFG 520 ++ +P A ++ADFG Sbjct: 166 LLY------ATPAPDAPLKIADFG 183
>CDK2_BOVIN (Q5E9Y0) Cell division protein kinase 2 (EC 2.7.11.22)| Length = 298 Score = 58.5 bits (140), Expect = 1e-08 Identities = 39/150 (26%), Positives = 69/150 (46%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 +GVV++ ++ TGE A+K +++ L +P +V++ V Sbjct: 15 YGVVYKAKNKLTGEVVALKKIRLDTETEGVPSTAIR---EISLLKELNHPNIVKLLDVIH 71 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 ++ ++V + DL ++ +P P+ + QL Q LA CH V+HRD+KP Sbjct: 72 TENKLYLVFEFLH-QDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKP 130 Query: 449 DNVVLDVDDEGENGSPRARLADFGSAAWIG 538 N++++ D +LADFG A G Sbjct: 131 QNLLINADGS-------IKLADFGLARAFG 153
>CDPK1_PLAFK (P62343) Calcium-dependent protein kinase 1 (EC 2.7.11.1) (PfCPK)| (PfCDPK1) Length = 523 Score = 58.5 bits (140), Expect = 1e-08 Identities = 29/117 (24%), Positives = 64/117 (54%) Frame = +2 Query: 194 EIEPKLAQLAAAGNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAA 373 EI +++ L + +P ++++ V+ED + ++V + G +L + + R E AA Sbjct: 111 EIYNEISLLKSLDHPNIIKLFDVFEDKKYFYLVTEFYEGGELFEQIINRH--KFDECDAA 168 Query: 374 DIVAQLAQALALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSAAWIGAD 544 +I+ Q+ + H+ ++HRD+KP+N++L E ++ ++ DFG +++ D Sbjct: 169 NIMKQILSGICYLHKHNIVHRDIKPENILL----ENKHSLLNIKIVDFGLSSFFSKD 221
>CDPK1_PLAF7 (P62344) Calcium-dependent protein kinase 1 (EC 2.7.11.1)| Length = 523 Score = 58.5 bits (140), Expect = 1e-08 Identities = 29/117 (24%), Positives = 64/117 (54%) Frame = +2 Query: 194 EIEPKLAQLAAAGNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAA 373 EI +++ L + +P ++++ V+ED + ++V + G +L + + R E AA Sbjct: 111 EIYNEISLLKSLDHPNIIKLFDVFEDKKYFYLVTEFYEGGELFEQIINRH--KFDECDAA 168 Query: 374 DIVAQLAQALALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSAAWIGAD 544 +I+ Q+ + H+ ++HRD+KP+N++L E ++ ++ DFG +++ D Sbjct: 169 NIMKQILSGICYLHKHNIVHRDIKPENILL----ENKHSLLNIKIVDFGLSSFFSKD 221
>PKN2_CLOPE (Q8XJL8) Probable serine/threonine protein kinase CPE1738 (EC| 2.7.11.1) Length = 685 Score = 58.5 bits (140), Expect = 1e-08 Identities = 39/103 (37%), Positives = 57/103 (55%) Frame = +2 Query: 218 LAAAGNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQ 397 +A NP VV V V D ++VM+ G L D ++ +GA +P VA I ++A+ Sbjct: 62 IANLSNPNVVNVLDVGTQDDINYIVMEYVEGKTLKDIIK-EKGA-LPYEVAISIGIKVAK 119 Query: 398 ALALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSA 526 AL H+ G+IHRDVKP N++ V +EG ++ DFG A Sbjct: 120 ALECAHKSGIIHRDVKPQNIL--VTEEGV-----VKVTDFGIA 155
>DAPK2_HUMAN (Q9UIK4) Death-associated protein kinase 2 (EC 2.7.11.1) (DAP| kinase 2) (DAP-kinase-related protein 1) (DRP-1) Length = 370 Score = 58.2 bits (139), Expect = 2e-08 Identities = 39/147 (26%), Positives = 70/147 (47%), Gaps = 1/147 (0%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXX-ELAEIEPKLAQLAAAGNPGVVQVHAVY 265 F +V +C +STG +A K EIE +++ L + V+ +H VY Sbjct: 34 FAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQVLHHNVITLHDVY 93 Query: 266 EDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVK 445 E+ + ++++L SG +L D+ L + + E A + Q+ + H + + H D+K Sbjct: 94 ENRTDVVLILELVSGGELFDF--LAQKESLSEEEATSFIKQILDGVNYLHTKKIAHFDLK 151 Query: 446 PDNVVLDVDDEGENGSPRARLADFGSA 526 P+N++L + P +L DFG A Sbjct: 152 PENIML---LDKNIPIPHIKLIDFGLA 175
>ST17B_HUMAN (O94768) Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP| kinase-related apoptosis-inducing protein kinase 2) Length = 372 Score = 58.2 bits (139), Expect = 2e-08 Identities = 40/152 (26%), Positives = 73/152 (48%), Gaps = 2/152 (1%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGN-PGVVQVHAVY 265 F VV +C S+STG+ +A K AEI ++A L A + P V+ +H VY Sbjct: 44 FAVVRQCISKSTGQEYAAKFLKKRRRGQDCR---AEILHEIAVLELAKSCPRVINLHEVY 100 Query: 266 EDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVK 445 E+ S ++++ +G ++ V E ++ Q+ + + H+ ++H D+K Sbjct: 101 ENTSEIILILEYAAGGEIFSLCLPELAEMVSENDVIRLIKQILEGVYYLHQNNIVHLDLK 160 Query: 446 PDNVVL-DVDDEGENGSPRARLADFGSAAWIG 538 P N++L + G+ ++ DFG + IG Sbjct: 161 PQNILLSSIYPLGD-----IKIVDFGMSRKIG 187
>WIS4_SCHPO (O14299) MAP kinase kinase kinase wis4 (EC 2.7.11.25) (MAP kinase| kinase kinase wak1) (MAP kinase kinase kinase wik1) Length = 1401 Score = 58.2 bits (139), Expect = 2e-08 Identities = 42/149 (28%), Positives = 65/149 (43%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 FG V+ + TG+ AVK + +I ++ L +P VV + V Sbjct: 1048 FGDVYTGVNMETGDLLAVKEIKLQDSRTFRST-VDQIHNEMTVLERLNHPNVVTYYGVEV 1106 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 ++ M+ C G L D L G E V V QL + LA H + ++HRD+KP Sbjct: 1107 HREKVYIFMEFCQGGSLADL--LAHGRIEDENVLKVYVVQLLEGLAYIHSQHILHRDIKP 1164 Query: 449 DNVVLDVDDEGENGSPRARLADFGSAAWI 535 N++LD + +DFGSA ++ Sbjct: 1165 ANILLD-------HRGMIKYSDFGSALYV 1186
>KPCE_RAT (P09216) Protein kinase C epsilon type (EC 2.7.11.13)| (nPKC-epsilon) Length = 737 Score = 58.2 bits (139), Expect = 2e-08 Identities = 44/174 (25%), Positives = 75/174 (43%), Gaps = 4/174 (2%) Frame = +2 Query: 11 PEENH*TMSGELNR----DYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKXXXXXXXXXXX 178 P EN G+ R ++ FG V + E +AVK Sbjct: 389 PGENGEVRQGQAKRLGLDEFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDD 448 Query: 179 XXELAEIEPKLAQLAAAGNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVP 358 + E ++ LA +P + Q++ ++ VM+ +G DL+ +++R Sbjct: 449 DVDCTMTEKRILALARK-HPYLTQLYCCFQTKDRLFFVMEYVNGGDLM--FQIQRSRKFD 505 Query: 359 EPVAADIVAQLAQALALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFG 520 EP + A++ AL H+ GVI+RD+K DN++LD + ++LADFG Sbjct: 506 EPRSGFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEG-------HSKLADFG 552
>KPK19_ARATH (Q39030) Serine/threonine-protein kinase AtPK19 (EC 2.7.11.1)| (Ribosomal-protein S6 kinase homolog) Length = 471 Score = 58.2 bits (139), Expect = 2e-08 Identities = 44/175 (25%), Positives = 79/175 (45%), Gaps = 1/175 (0%) Frame = +2 Query: 5 RKPEENH*TMSGELN-RDYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKXXXXXXXXXXXX 181 + PEE +SG + D+ FG V++ + T E +A+K Sbjct: 126 KSPEE----VSGVVGIEDFEVLKVVGQGAFGKVYQVRKKDTSEIYAMKVMRKDKIVEKNH 181 Query: 182 XELAEIEPKLAQLAAAGNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPE 361 E + E + L +P +VQ+ ++ ++V+D +G L + +L E Sbjct: 182 AEYMKAERDI--LTKIDHPFIVQLKYSFQTKYRLYLVLDFINGGHL--FFQLYHQGLFRE 237 Query: 362 PVAADIVAQLAQALALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSA 526 +A A++ A++ H +G++HRD+KP+N+++DVD L DFG A Sbjct: 238 DLARVYTAEIVSAVSHLHEKGIMHRDLKPENILMDVDG-------HVMLTDFGLA 285
>KPCL_RAT (Q64617) Protein kinase C eta type (EC 2.7.11.13) (nPKC-eta)| (PKC-L) Length = 683 Score = 58.2 bits (139), Expect = 2e-08 Identities = 43/144 (29%), Positives = 66/144 (45%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 FG V + TGE +AVK E E ++ LA +P + Q+ ++ Sbjct: 366 FGKVMLARIKETGELYAVKVLKKDVILQDDDVECTMTEKRILSLAR-NHPFLTQLFCCFQ 424 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 VM+ +G DL+ +++ E A A++ AL H +G+I+RD+K Sbjct: 425 TPDRLFFVMEFVNGGDLM--FHIQKSRRFDEARARFYAAEIISALMFLHEKGIIYRDLKL 482 Query: 449 DNVVLDVDDEGENGSPRARLADFG 520 DNV+L D EG +LADFG Sbjct: 483 DNVLL--DHEG-----HCKLADFG 499
>KPCL_MOUSE (P23298) Protein kinase C eta type (EC 2.7.11.13) (nPKC-eta)| (PKC-L) Length = 683 Score = 58.2 bits (139), Expect = 2e-08 Identities = 43/144 (29%), Positives = 66/144 (45%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 FG V + TGE +AVK E E ++ LA +P + Q+ ++ Sbjct: 366 FGKVMLARIKETGELYAVKVLKKDVILQDDDVECTMTEKRILSLAR-NHPFLTQLFCCFQ 424 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 VM+ +G DL+ +++ E A A++ AL H +G+I+RD+K Sbjct: 425 TPDRLFFVMEFVNGGDLM--FHIQKSRRFDEARARFYAAEIISALMFLHEKGIIYRDLKL 482 Query: 449 DNVVLDVDDEGENGSPRARLADFG 520 DNV+L D EG +LADFG Sbjct: 483 DNVLL--DHEG-----HCKLADFG 499
>STK6_XENLA (Q91820) Serine/threonine-protein kinase Eg2 (EC 2.7.11.1) (pEg2)| (p46Eg265) Length = 407 Score = 58.2 bits (139), Expect = 2e-08 Identities = 31/96 (32%), Positives = 56/96 (58%) Frame = +2 Query: 233 NPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALC 412 +P +++++ + D S ++++D G +L L++ + +A + QLA+AL C Sbjct: 197 HPNILRLYGYFHDASRVYLILDYAPGGELFR--ELQKCTRFDDQRSAMYIKQLAEALLYC 254 Query: 413 HRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFG 520 H + VIHRD+KP+N++L G NG ++ADFG Sbjct: 255 HSKKVIHRDIKPENLLL-----GSNG--ELKIADFG 283
>OXSR1_MOUSE (Q6P9R2) Serine/threonine-protein kinase OSR1 (EC 2.7.11.1)| (Oxidative stress-responsive 1 protein) Length = 527 Score = 58.2 bits (139), Expect = 2e-08 Identities = 38/126 (30%), Positives = 67/126 (53%), Gaps = 8/126 (6%) Frame = +2 Query: 194 EIEPKLAQLAAAGNPGVVQVHA--VYEDDSWTHMVMDLCSGPDLLDWVRL------RRGA 349 E+ ++ ++ +P +V + V +D+ W +VM L SG +LD ++ + Sbjct: 59 ELLKEIQAMSQCHHPNIVSYYTSFVVKDELW--LVMKLLSGGSVLDIIKHIVAKGEHKSG 116 Query: 350 PVPEPVAADIVAQLAQALALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSAA 529 + EP A I+ ++ + L H+ G IHRDVK N++L GE+GS ++ADFG +A Sbjct: 117 VLDEPTIATILREVLEGLEYLHKNGQIHRDVKAGNILL-----GEDGS--VQIADFGVSA 169 Query: 530 WIGADG 547 ++ G Sbjct: 170 FLATGG 175
>CPK24_ARATH (Q9LDI3) CBL-interacting serine/threonine-protein kinase 24 (EC| 2.7.11.1) (SNF1-related kinase 3.11) (SALT OVERLY SENSITIVE 2 protein) Length = 446 Score = 58.2 bits (139), Expect = 2e-08 Identities = 39/147 (26%), Positives = 74/147 (50%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 F V + TG+ A+K + +I+ +++ + +P +V+++ V Sbjct: 22 FAKVKFARNTDTGDNVAIKIMAKSTILKNRMVD--QIKREISIMKIVRHPNIVRLYEVLA 79 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 S ++V++ +G +L D R+ + E + QL A+A CH +GV HRD+KP Sbjct: 80 SPSKIYIVLEFVTGGELFD--RIVHKGRLEESESRKYFQQLVDAVAHCHCKGVYHRDLKP 137 Query: 449 DNVVLDVDDEGENGSPRARLADFGSAA 529 +N++LD NG+ +++DFG +A Sbjct: 138 ENLLLDT-----NGN--LKVSDFGLSA 157
>ULK2_HUMAN (Q8IYT8) Serine/threonine-protein kinase ULK2 (EC 2.7.11.1)| (Unc-51-like kinase 2) Length = 1036 Score = 57.8 bits (138), Expect = 2e-08 Identities = 30/100 (30%), Positives = 58/100 (58%), Gaps = 2/100 (2%) Frame = +2 Query: 242 VVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRR 421 +V ++ V E + +VM+ C+G DL D+++ + + E + Q+A A+ + H + Sbjct: 68 IVALYDVQELPNSVFLVMEYCNGGDLADYLQAK--GTLSEDTIRVFLHQIAAAMRILHSK 125 Query: 422 GVIHRDVKPDNVVLDVDDEGEN--GSPRARLADFGSAAWI 535 G+IHRD+KP N++L + ++ R ++ADFG A ++ Sbjct: 126 GIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYL 165
>ST17B_MOUSE (Q8BG48) Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP| kinase-related apoptosis-inducing protein kinase 2) Length = 372 Score = 57.8 bits (138), Expect = 2e-08 Identities = 40/152 (26%), Positives = 74/152 (48%), Gaps = 2/152 (1%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGN-PGVVQVHAVY 265 F VV +C S+STG+ +A K AEI ++A L A + P V+ +H VY Sbjct: 44 FAVVRQCISKSTGQEYAAKSLKKRRRGQDCR---AEILHEIAVLELARSCPHVINLHEVY 100 Query: 266 EDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVK 445 E+ + +V++ +G ++ + V E ++ Q+ + + H+ ++H D+K Sbjct: 101 ENATEIILVLEYAAGGEIFNLCLPELAEMVSENDVIRLIKQILEGVHYLHQNNIVHLDLK 160 Query: 446 PDNVVL-DVDDEGENGSPRARLADFGSAAWIG 538 P N++L + G+ ++ DFG + IG Sbjct: 161 PQNILLSSIYPLGD-----IKIVDFGMSRKIG 187
>ULK2_MOUSE (Q9QY01) Serine/threonine-protein kinase ULK2 (EC 2.7.11.1)| (Unc-51-like kinase 2) (Serine/threonine-protein kinase Unc51.2) Length = 1037 Score = 57.8 bits (138), Expect = 2e-08 Identities = 30/100 (30%), Positives = 58/100 (58%), Gaps = 2/100 (2%) Frame = +2 Query: 242 VVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRR 421 +V ++ V E + +VM+ C+G DL D+++ + + E + Q+A A+ + H + Sbjct: 68 IVALYDVQELPNSVFLVMEYCNGGDLADYLQAK--GTLSEDTIRVFLHQIAAAMRILHSK 125 Query: 422 GVIHRDVKPDNVVLDVDDEGEN--GSPRARLADFGSAAWI 535 G+IHRD+KP N++L + ++ R ++ADFG A ++ Sbjct: 126 GIIHRDLKPQNILLSYANRRKSNVSGIRIKIADFGFARYL 165
>NEK3_HUMAN (P51956) Serine/threonine-protein kinase Nek3 (EC 2.7.11.1)| (NimA-related protein kinase 3) (HSPK 36) Length = 506 Score = 57.8 bits (138), Expect = 2e-08 Identities = 31/103 (30%), Positives = 55/103 (53%) Frame = +2 Query: 218 LAAAGNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQ 397 LA +P +V +E + ++VM+ C G DL+ ++ ++G PE + + Q+ Sbjct: 54 LAKMKHPNIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCL 113 Query: 398 ALALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSA 526 + H++ V+HRD+K N+ L +NG + +L DFGSA Sbjct: 114 GVNHIHKKRVLHRDIKSKNIFLT-----QNG--KVKLGDFGSA 149
>DCAK1_RAT (O08875) Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1)| (Doublecortin-like and CAM kinase-like 1) (Calcium/calmodulin-dependent protein kinase type I-like CPG16) Length = 433 Score = 57.8 bits (138), Expect = 2e-08 Identities = 40/146 (27%), Positives = 70/146 (47%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 F VV C RST +A+K I+ +++ L +P +V + + Sbjct: 94 FAVVKECIERSTAREYALKIIKKSKCRGKEHM----IQNEVSILRRVKHPNIVLLIEEMD 149 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 + ++VM+L G DL D + + E A+ ++ LA A+ H ++HRD+KP Sbjct: 150 VPTELYLVMELVKGGDLFD--AITSTSKYTERDASGMLYNLASAIKYLHSLNIVHRDIKP 207 Query: 449 DNVVLDVDDEGENGSPRARLADFGSA 526 +N+++ E ++GS +L DFG A Sbjct: 208 ENLLV---YEHQDGSKSLKLGDFGLA 230
>STK6L_XENLA (Q91819) Serine/threonine-protein kinase Eg2-like (EC 2.7.11.1)| (p46XlEg22) Length = 408 Score = 57.8 bits (138), Expect = 2e-08 Identities = 31/96 (32%), Positives = 56/96 (58%) Frame = +2 Query: 233 NPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALC 412 +P +++++ + D S ++++D G +L L++ + +A + QLA+AL C Sbjct: 197 HPNILRLYGYFHDASRVYLILDYAPGGELFR--ELQKCTRFDDQRSALYIKQLAEALLYC 254 Query: 413 HRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFG 520 H + VIHRD+KP+N++L G NG ++ADFG Sbjct: 255 HSKKVIHRDIKPENLLL-----GSNG--ELKIADFG 283
>STK39_HUMAN (Q9UEW8) STE20/SPS1-related proline-alanine-rich protein kinase (EC| 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39) (DCHT) Length = 547 Score = 57.8 bits (138), Expect = 2e-08 Identities = 38/126 (30%), Positives = 67/126 (53%), Gaps = 8/126 (6%) Frame = +2 Query: 194 EIEPKLAQLAAAGNPGVVQVHA--VYEDDSWTHMVMDLCSGPDLLDWVRL------RRGA 349 E+ ++ ++ +P VV + V +D+ W +VM L SG +LD ++ + Sbjct: 107 ELLKEIQAMSQCSHPNVVTYYTSFVVKDELW--LVMKLLSGGSMLDIIKYIVNRGEHKNG 164 Query: 350 PVPEPVAADIVAQLAQALALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSAA 529 + E + A I+ ++ + L HR G IHRD+K N++L GE+GS ++ADFG +A Sbjct: 165 VLEEAIIATILKEVLEGLDYLHRNGQIHRDLKAGNILL-----GEDGS--VQIADFGVSA 217 Query: 530 WIGADG 547 ++ G Sbjct: 218 FLATGG 223
>KG1Z_YEAST (P53233) Probable serine/threonine-protein kinase YGR052W (EC| 2.7.11.1) Length = 369 Score = 57.8 bits (138), Expect = 2e-08 Identities = 33/104 (31%), Positives = 58/104 (55%), Gaps = 6/104 (5%) Frame = +2 Query: 233 NPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRR--GAPV-PEPVAAD---IVAQLA 394 +P + + Y DDS+ MV++ C DL D++ + + G+P P + D I+ QL Sbjct: 59 HPNICSMLDFYTDDSYYIMVLEYCECGDLYDFLDIAKSQGSPSSPSLIQIDMQKIIKQLC 118 Query: 395 QALALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSA 526 A++ H G+ HRD+KP+N++L ++ + +LAD+G A Sbjct: 119 SAISFAHSLGIAHRDIKPENILLTINGD-------IKLADWGHA 155
>CDK3_MOUSE (Q80YP0) Truncated cell division protein kinase 3 homolog| Length = 186 Score = 57.8 bits (138), Expect = 2e-08 Identities = 40/150 (26%), Positives = 70/150 (46%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 +GVV++ ++ TG+ A+K +++ L +P ++++ V Sbjct: 15 YGVVYKARNKVTGQLVALKKIRLDLEAEGVPSTAVR---EISLLKELKHPNIIKLLDVVH 71 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 + +MV + + DL + + +P PV +AQL + ++ CH VIHRD+KP Sbjct: 72 REKKLYMVFEFLT-QDLKRHMDSSPTSELPLPVVKSYLAQLLEGVSFCHSHRVIHRDLKP 130 Query: 449 DNVVLDVDDEGENGSPRARLADFGSAAWIG 538 N++LD G +LADFG A G Sbjct: 131 QNLLLD-------GLGAIKLADFGLARAFG 153
>DCAK1_MOUSE (Q9JLM8) Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1)| (Doublecortin-like and CAM kinase-like 1) Length = 756 Score = 57.8 bits (138), Expect = 2e-08 Identities = 40/146 (27%), Positives = 70/146 (47%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 F VV C RST +A+K I+ +++ L +P +V + + Sbjct: 417 FAVVKECIERSTAREYALKIIKKSKCRGKEHM----IQNEVSILRRVKHPNIVLLIEEMD 472 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 + ++VM+L G DL D + + E A+ ++ LA A+ H ++HRD+KP Sbjct: 473 VPTELYLVMELVKGGDLFD--AITSTSKYTERDASGMLYNLASAIKYLHSLNIVHRDIKP 530 Query: 449 DNVVLDVDDEGENGSPRARLADFGSA 526 +N+++ E ++GS +L DFG A Sbjct: 531 ENLLV---YEHQDGSKSLKLGDFGLA 553
>STK39_RAT (O88506) STE20/SPS1-related proline-alanine-rich protein kinase (EC| 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39) (Pancreatic serine/threonine-protein kinase) (PS/TK) (PSTK1) Length = 553 Score = 57.8 bits (138), Expect = 2e-08 Identities = 38/126 (30%), Positives = 67/126 (53%), Gaps = 8/126 (6%) Frame = +2 Query: 194 EIEPKLAQLAAAGNPGVVQVHA--VYEDDSWTHMVMDLCSGPDLLDWVRL------RRGA 349 E+ ++ ++ +P VV + V +D+ W +VM L SG +LD ++ + Sbjct: 114 ELLKEIQAMSQCSHPNVVTYYTSFVVKDELW--LVMKLLSGGSMLDIIKYIVNRGEHKNG 171 Query: 350 PVPEPVAADIVAQLAQALALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSAA 529 + E + A I+ ++ + L HR G IHRD+K N++L GE+GS ++ADFG +A Sbjct: 172 VLEEAIIATILKEVLEGLDYLHRNGQIHRDLKAGNILL-----GEDGS--VQIADFGVSA 224 Query: 530 WIGADG 547 ++ G Sbjct: 225 FLATGG 230
>CDPK3_PLAYO (Q7RAV5) Calcium-dependent protein kinase 3 (EC 2.7.11.1)| Length = 538 Score = 57.8 bits (138), Expect = 2e-08 Identities = 34/100 (34%), Positives = 60/100 (60%) Frame = +2 Query: 233 NPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALC 412 +P V+++ +ED+ +++MDLC+G +L D + +++G+ V E A+ I+ Q+ L Sbjct: 166 HPNVIKLLETFEDEEQIYLIMDLCTGGELFDKI-IKKGSFV-EMYASFIMKQIFSVLNYL 223 Query: 413 HRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSAAW 532 H R + HRD+KP+N L D E+ ++ DFG AA+ Sbjct: 224 HIRNICHRDIKPEN-FLFYDKSTES---LIKIIDFGLAAY 259
>CDK2_CRIGR (O55076) Cell division protein kinase 2 (EC 2.7.11.22)| Length = 298 Score = 57.8 bits (138), Expect = 2e-08 Identities = 39/150 (26%), Positives = 68/150 (45%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 +GVV++ ++ TGE A+K +++ L +P +V++ V Sbjct: 15 YGVVYKAKNKLTGEVVALKKIRLDTETEGVPSTAIR---EISLLKELNHPNIVKLLDVIH 71 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 ++ ++V + DL ++ +P P+ + QL Q LA CH V+HRD+KP Sbjct: 72 TENKLYLVFEFLH-QDLKKFMDASAVTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKP 130 Query: 449 DNVVLDVDDEGENGSPRARLADFGSAAWIG 538 N+++ N +LADFG A G Sbjct: 131 QNLLI-------NAEGSIKLADFGLARAFG 153
>STK39_MOUSE (Q9Z1W9) STE20/SPS1-related proline-alanine-rich protein kinase (EC| 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39) Length = 556 Score = 57.8 bits (138), Expect = 2e-08 Identities = 38/126 (30%), Positives = 67/126 (53%), Gaps = 8/126 (6%) Frame = +2 Query: 194 EIEPKLAQLAAAGNPGVVQVHA--VYEDDSWTHMVMDLCSGPDLLDWVRL------RRGA 349 E+ ++ ++ +P VV + V +D+ W +VM L SG +LD ++ + Sbjct: 117 ELLKEIQAMSQCSHPNVVTYYTSFVVKDELW--LVMKLLSGGSMLDIIKYIVNRGEHKNG 174 Query: 350 PVPEPVAADIVAQLAQALALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSAA 529 + E + A I+ ++ + L HR G IHRD+K N++L GE+GS ++ADFG +A Sbjct: 175 VLEEAIIATILKEVLEGLDYLHRNGQIHRDLKAGNILL-----GEDGS--VQIADFGVSA 227 Query: 530 WIGADG 547 ++ G Sbjct: 228 FLATGG 233
>PASK_MOUSE (Q8CEE6) PAS domain-containing serine/threonine-protein kinase (EC| 2.7.11.1) (PAS-kinase) (PASKIN) Length = 1383 Score = 57.8 bits (138), Expect = 2e-08 Identities = 44/170 (25%), Positives = 76/170 (44%), Gaps = 4/170 (2%) Frame = +2 Query: 38 GELNRDYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXE---LAEIEPK 208 GE + Y FG V + + VK E L + + Sbjct: 1053 GEYDYKYNTISPLGSGAFGFVWTAVEKECNKEVVVKFIKKEKVLEDCWIEDPKLGRVTLE 1112 Query: 209 LAQLAAAGNPGVVQVHAVYEDDSWTHMVMDLC-SGPDLLDWVRLRRGAPVPEPVAADIVA 385 +A L+ + +++V ++E+ + +VM+ SG DL ++ + EP+A+ I Sbjct: 1113 IAILSKVDHANIIKVLDIFENQEFFQLVMEKHGSGMDLFAFID--HHPCLDEPLASFIFR 1170 Query: 386 QLAQALALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSAAWI 535 QL A+ H +G+IHRD+K +N+V+ D +L DFGSAA++ Sbjct: 1171 QLVSAVGYLHSQGIIHRDIKDENIVIAEDF-------TIKLIDFGSAAYL 1213
>DCAK1_HUMAN (O15075) Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1)| (Doublecortin-like and CAM kinase-like 1) Length = 740 Score = 57.4 bits (137), Expect = 3e-08 Identities = 40/146 (27%), Positives = 69/146 (47%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 F VV C RST +A+K I+ +++ L +P +V + + Sbjct: 401 FAVVKECVERSTAREYALKIIKKSKCRGKEHM----IQNEVSILRRVKHPNIVLLIEEMD 456 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 + ++VM+L G DL D + E A+ ++ LA A+ H ++HRD+KP Sbjct: 457 VPTELYLVMELVKGGDLFDAITSTN--KYTERDASGMLYNLASAIKYLHSLNIVHRDIKP 514 Query: 449 DNVVLDVDDEGENGSPRARLADFGSA 526 +N+++ E ++GS +L DFG A Sbjct: 515 ENLLV---YEHQDGSKSLKLGDFGLA 537
>KGP1A_RABIT (O77676) cGMP-dependent protein kinase 1, alpha isozyme (EC| 2.7.11.12) (CGK 1 alpha) (cGKI-alpha) Length = 670 Score = 57.4 bits (137), Expect = 3e-08 Identities = 38/137 (27%), Positives = 65/137 (47%) Frame = +2 Query: 128 EAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYEDDSWTHMVMDLCS 307 + FA+K E E ++ Q A + +V+++ ++D + +M+M+ C Sbjct: 384 KTFAMKILKKRHIVDTRQQEHIRSEKQIMQ--GAHSDFIVRLYRTFKDSKYLYMLMEACL 441 Query: 308 GPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKPDNVVLDVDDEGEN 487 G +L W LR + A + +A A H +G+I+RD+KP+N++LD Sbjct: 442 GGEL--WTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILD------- 492 Query: 488 GSPRARLADFGSAAWIG 538 A+L DFG A IG Sbjct: 493 HRGYAKLVDFGFAKKIG 509
>KGP1A_HUMAN (Q13976) cGMP-dependent protein kinase 1, alpha isozyme (EC| 2.7.11.12) (CGK 1 alpha) (cGKI-alpha) Length = 670 Score = 57.4 bits (137), Expect = 3e-08 Identities = 38/137 (27%), Positives = 65/137 (47%) Frame = +2 Query: 128 EAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYEDDSWTHMVMDLCS 307 + FA+K E E ++ Q A + +V+++ ++D + +M+M+ C Sbjct: 384 KTFAMKILKKRHIVDTRQQEHIRSEKQIMQ--GAHSDFIVRLYRTFKDSKYLYMLMEACL 441 Query: 308 GPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKPDNVVLDVDDEGEN 487 G +L W LR + A + +A A H +G+I+RD+KP+N++LD Sbjct: 442 GGEL--WTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILD------- 492 Query: 488 GSPRARLADFGSAAWIG 538 A+L DFG A IG Sbjct: 493 HRGYAKLVDFGFAKKIG 509
>KGP1A_BOVIN (P00516) cGMP-dependent protein kinase 1, alpha isozyme (EC| 2.7.11.12) (CGK 1 alpha) (cGKI-alpha) Length = 670 Score = 57.4 bits (137), Expect = 3e-08 Identities = 38/137 (27%), Positives = 65/137 (47%) Frame = +2 Query: 128 EAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYEDDSWTHMVMDLCS 307 + FA+K E E ++ Q A + +V+++ ++D + +M+M+ C Sbjct: 384 KTFAMKILKKRHIVDTRQQEHIRSEKQIMQ--GAHSDFIVRLYRTFKDSKYLYMLMEACL 441 Query: 308 GPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKPDNVVLDVDDEGEN 487 G +L W LR + A + +A A H +G+I+RD+KP+N++LD Sbjct: 442 GGEL--WTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILD------- 492 Query: 488 GSPRARLADFGSAAWIG 538 A+L DFG A IG Sbjct: 493 HRGYAKLVDFGFAKKIG 509
>PKNB_LACLA (Q9CEF5) Probable serine/threonine-protein kinase pknB (EC| 2.7.11.1) Length = 627 Score = 57.4 bits (137), Expect = 3e-08 Identities = 31/113 (27%), Positives = 59/113 (52%) Frame = +2 Query: 188 LAEIEPKLAQLAAAGNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPV 367 +A + + +A +P +V + V E +S ++VM+ G L ++ + AP+ Sbjct: 55 IARFQREAFAMAELSHPNIVGISDVGEFESQQYIVMEFVDGMTLKQYIN--QNAPLANDE 112 Query: 368 AADIVAQLAQALALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSA 526 A +I+ ++ A+ + H G+IHRD+KP NV++ + S ++ DFG A Sbjct: 113 AIEIITEILSAMDMAHSHGIIHRDLKPQNVLV-------SSSGTVKVTDFGIA 158
>SCK2_SCHPO (Q10364) Serine/threonine-protein kinase sck2 (EC 2.7.11.1)| Length = 646 Score = 57.4 bits (137), Expect = 3e-08 Identities = 34/104 (32%), Positives = 56/104 (53%) Frame = +2 Query: 209 LAQLAAAGNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQ 388 L Q +AA +P +V + ++ ++V D +G +L W L++ PE A +A+ Sbjct: 318 LVQTSAADSPFIVALRFSFQTPKDLYLVTDYMAGGELF-W-HLQKSVRFPEERAKFYIAE 375 Query: 389 LAQALALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFG 520 L AL H+RG+++RD+KP+N++LDV L DFG Sbjct: 376 LLLALQALHKRGIVYRDLKPENILLDVQG-------HIALCDFG 412
>KGP1B_MOUSE (Q9Z0Z0) cGMP-dependent protein kinase 1, beta isozyme (EC| 2.7.11.12) (cGK 1 beta) (cGKI-beta) Length = 686 Score = 57.4 bits (137), Expect = 3e-08 Identities = 38/137 (27%), Positives = 65/137 (47%) Frame = +2 Query: 128 EAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYEDDSWTHMVMDLCS 307 + FA+K E E ++ Q A + +V+++ ++D + +M+M+ C Sbjct: 400 KTFAMKILKKRHIVDTRQQEHIRSEKQIMQ--GAHSDFIVRLYRTFKDSKYLYMLMEACL 457 Query: 308 GPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKPDNVVLDVDDEGEN 487 G +L W LR + A + +A A H +G+I+RD+KP+N++LD Sbjct: 458 GGEL--WTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILD------- 508 Query: 488 GSPRARLADFGSAAWIG 538 A+L DFG A IG Sbjct: 509 HRGYAKLVDFGFAKKIG 525
>KGP1B_HUMAN (P14619) cGMP-dependent protein kinase 1, beta isozyme (EC| 2.7.11.12) (cGK 1 beta) (cGKI-beta) Length = 686 Score = 57.4 bits (137), Expect = 3e-08 Identities = 38/137 (27%), Positives = 65/137 (47%) Frame = +2 Query: 128 EAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYEDDSWTHMVMDLCS 307 + FA+K E E ++ Q A + +V+++ ++D + +M+M+ C Sbjct: 400 KTFAMKILKKRHIVDTRQQEHIRSEKQIMQ--GAHSDFIVRLYRTFKDSKYLYMLMEACL 457 Query: 308 GPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKPDNVVLDVDDEGEN 487 G +L W LR + A + +A A H +G+I+RD+KP+N++LD Sbjct: 458 GGEL--WTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILD------- 508 Query: 488 GSPRARLADFGSAAWIG 538 A+L DFG A IG Sbjct: 509 HRGYAKLVDFGFAKKIG 525
>KGP1B_BOVIN (P21136) cGMP-dependent protein kinase 1, beta isozyme (EC| 2.7.11.12) (cGK 1 beta) (cGKI-beta) Length = 686 Score = 57.4 bits (137), Expect = 3e-08 Identities = 38/137 (27%), Positives = 65/137 (47%) Frame = +2 Query: 128 EAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYEDDSWTHMVMDLCS 307 + FA+K E E ++ Q A + +V+++ ++D + +M+M+ C Sbjct: 400 KTFAMKILKKRHIVDTRQQEHIRSEKQIMQ--GAHSDFIVRLYRTFKDSKYLYMLMEACL 457 Query: 308 GPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKPDNVVLDVDDEGEN 487 G +L W LR + A + +A A H +G+I+RD+KP+N++LD Sbjct: 458 GGEL--WTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILD------- 508 Query: 488 GSPRARLADFGSAAWIG 538 A+L DFG A IG Sbjct: 509 HRGYAKLVDFGFAKKIG 525
>KPCZ_RAT (P09217) Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta)| Length = 592 Score = 57.4 bits (137), Expect = 3e-08 Identities = 33/99 (33%), Positives = 55/99 (55%) Frame = +2 Query: 224 AAGNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQAL 403 A+ NP +V +H+ ++ S +V++ +G DL+ ++R +PE A A++ AL Sbjct: 307 ASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLM--FHMQRQRKLPEEHARFYAAEICIAL 364 Query: 404 ALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFG 520 H RG+I+RD+K DNV+LD D +L D+G Sbjct: 365 NFLHERGIIYRDLKLDNVLLDADG-------HIKLTDYG 396
>KPCZ_MOUSE (Q02956) Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta)| Length = 592 Score = 57.4 bits (137), Expect = 3e-08 Identities = 33/99 (33%), Positives = 55/99 (55%) Frame = +2 Query: 224 AAGNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQAL 403 A+ NP +V +H+ ++ S +V++ +G DL+ ++R +PE A A++ AL Sbjct: 307 ASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLM--FHMQRQRKLPEEHARFYAAEICIAL 364 Query: 404 ALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFG 520 H RG+I+RD+K DNV+LD D +L D+G Sbjct: 365 NFLHERGIIYRDLKLDNVLLDADG-------HIKLTDYG 396
>KPCZ_HUMAN (Q05513) Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta)| Length = 592 Score = 57.4 bits (137), Expect = 3e-08 Identities = 33/99 (33%), Positives = 55/99 (55%) Frame = +2 Query: 224 AAGNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQAL 403 A+ NP +V +H+ ++ S +V++ +G DL+ ++R +PE A A++ AL Sbjct: 307 ASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLM--FHMQRQRKLPEEHARFYAAEICIAL 364 Query: 404 ALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFG 520 H RG+I+RD+K DNV+LD D +L D+G Sbjct: 365 NFLHERGIIYRDLKLDNVLLDADG-------HIKLTDYG 396
>KPCE_HUMAN (Q02156) Protein kinase C epsilon type (EC 2.7.11.13)| (nPKC-epsilon) Length = 737 Score = 57.4 bits (137), Expect = 3e-08 Identities = 44/174 (25%), Positives = 74/174 (42%), Gaps = 4/174 (2%) Frame = +2 Query: 11 PEENH*TMSGELNR----DYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKXXXXXXXXXXX 178 P EN G+ R ++ FG V + E +AVK Sbjct: 389 PGENGEVRQGQAKRLGLDEFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDD 448 Query: 179 XXELAEIEPKLAQLAAAGNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVP 358 + E ++ LA +P + Q++ ++ VM+ +G DL+ +++R Sbjct: 449 DVDCTMTEKRILALARK-HPYLTQLYCCFQTKDRLFFVMEYVNGGDLM--FQIQRSRKFD 505 Query: 359 EPVAADIVAQLAQALALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFG 520 EP + A++ AL H+ GVI+RD+K DN++LD + +LADFG Sbjct: 506 EPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEG-------HCKLADFG 552
>CDK2_MOUSE (P97377) Cell division protein kinase 2 (EC 2.7.11.22)| Length = 346 Score = 57.4 bits (137), Expect = 3e-08 Identities = 39/150 (26%), Positives = 68/150 (45%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 +GVV++ ++ TGE A+K +++ L +P +V++ V Sbjct: 15 YGVVYKAKNKLTGEVVALKKIRLDTETEGVPSTAIR---EISLLKELNHPNIVKLLDVIH 71 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 ++ ++V + DL ++ +P P+ + QL Q LA CH V+HRD+KP Sbjct: 72 TENKLYLVFEFLH-QDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKP 130 Query: 449 DNVVLDVDDEGENGSPRARLADFGSAAWIG 538 N+++ N +LADFG A G Sbjct: 131 QNLLI-------NAEGSIKLADFGLARAFG 153
>RKIN1_SECCE (Q02723) Carbon catabolite derepressing protein kinase (EC| 2.7.11.1) Length = 502 Score = 57.4 bits (137), Expect = 3e-08 Identities = 44/161 (27%), Positives = 70/161 (43%), Gaps = 1/161 (0%) Frame = +2 Query: 41 ELNRDYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQL 220 E ++Y F V + T A+K E A+ E K+ +L Sbjct: 9 EALKNYYLGKILGVGTFAKVIIAEHKHTRHKVAIKVLNRRQMRAPEMEEKAKREIKILRL 68 Query: 221 AA-AGNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQ 397 +P +++V+ V +VM+ C DLLD++ +R + E A Q+ Sbjct: 69 FIDLIHPHIIRVYEVIVTPKDIFVVMEYCQNGDLLDYILEKRR--LQEDEARRTFQQIIS 126 Query: 398 ALALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFG 520 A+ CHR V+HRD+KP+N++LD +LADFG Sbjct: 127 AVEYCHRNKVVHRDLKPENLLLD-------SKYNVKLADFG 160
>ZYG1_CAEEL (Q9GT24) Probable serine/threonine-protein kinase zyg-1 (EC| 2.7.11.1) (Zygote defective protein 1) Length = 706 Score = 57.4 bits (137), Expect = 3e-08 Identities = 43/150 (28%), Positives = 70/150 (46%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 FGVV+ R GE A+K E+ ++ + VV+ + + Sbjct: 24 FGVVY-AAQRENGEKVAIKRIDKKVPKNRVWTEIQTMKE------LKKSKYVVEFYEDFV 76 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 +D +T++VM+LC G L +VR GA + + A ++ QL A++ HR VIHRD+ Sbjct: 77 EDGYTYIVMELCEGGSLQAYVR-EHGA-LDDATAVHVLRQLISAVSFMHRVNVIHRDLSA 134 Query: 449 DNVVLDVDDEGENGSPRARLADFGSAAWIG 538 NV + + + +L DFG A +G Sbjct: 135 GNVFI---KDSKKKKMTVKLGDFGLATTLG 161
>PKH1_YEAST (Q03407) Serine/threonine-protein kinase PKH1 (EC 2.7.11.1)| (3-phosphoinositide-dependent protein kinase 1) Length = 766 Score = 57.0 bits (136), Expect = 4e-08 Identities = 37/159 (23%), Positives = 73/159 (45%) Frame = +2 Query: 50 RDYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAA 229 +D+ + V T+R +G+ +AVK + +E KLA Sbjct: 123 KDFKFGEQLGDGSYSSVVLATARDSGKKYAVKVLSKEYLIRQKKVKYVTVE-KLALQKLN 181 Query: 230 GNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALAL 409 G G+ ++ ++D++ + +++ D L ++ + + E A +Q+ A+ Sbjct: 182 GTKGIFKLFFTFQDEASLYFLLEYAPHGDFLGLIK--KYGSLNETCARYYASQIIDAVDS 239 Query: 410 CHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSA 526 H G+IHRD+KP+N++LD + + +L DFG+A Sbjct: 240 LHNIGIIHRDIKPENILLD-------KNMKVKLTDFGTA 271
>PKNI_MYCTU (P65730) Probable serine/threonine-protein kinase pknI (EC| 2.7.11.1) Length = 585 Score = 57.0 bits (136), Expect = 4e-08 Identities = 37/99 (37%), Positives = 50/99 (50%) Frame = +2 Query: 233 NPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALC 412 +P +++VH E D + MD G D + R A +P IV +A AL Sbjct: 69 HPHILEVHDRGEFDGQLWIAMDYVDGIDATQHMADRFPAVLPVGEVLAIVTAVAGALDYA 128 Query: 413 HRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSAA 529 H+RG++HRDV P NVVL G+ R LADFG A+ Sbjct: 129 HQRGLLHRDVNPANVVLTSQSAGDQ---RILLADFGIAS 164
>PKNI_MYCBO (P65731) Probable serine/threonine-protein kinase pknI (EC| 2.7.11.1) Length = 585 Score = 57.0 bits (136), Expect = 4e-08 Identities = 37/99 (37%), Positives = 50/99 (50%) Frame = +2 Query: 233 NPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALC 412 +P +++VH E D + MD G D + R A +P IV +A AL Sbjct: 69 HPHILEVHDRGEFDGQLWIAMDYVDGIDATQHMADRFPAVLPVGEVLAIVTAVAGALDYA 128 Query: 413 HRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSAA 529 H+RG++HRDV P NVVL G+ R LADFG A+ Sbjct: 129 HQRGLLHRDVNPANVVLTSQSAGDQ---RILLADFGIAS 164
>KPCA_MOUSE (P20444) Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha)| (PKC-A) Length = 671 Score = 57.0 bits (136), Expect = 4e-08 Identities = 44/174 (25%), Positives = 76/174 (43%), Gaps = 4/174 (2%) Frame = +2 Query: 11 PEENH*TMSGELNR----DYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKXXXXXXXXXXX 178 P E+ S L+R D+ FG V + T E +A+K Sbjct: 319 PSEDRKQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDD 378 Query: 179 XXELAEIEPKLAQLAAAGNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVP 358 E +E ++ L P + Q+H+ ++ + VM+ +G DL+ +++ Sbjct: 379 DVECTMVEKRVLALLDKP-PFLTQLHSCFQTVDRLYFVMEYVNGGDLM--YHIQQVGKFK 435 Query: 359 EPVAADIVAQLAQALALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFG 520 EP A A+++ L H+RG+I+RD+K +NV+L N ++ADFG Sbjct: 436 EPQAVFYAAEISIGLFFLHKRGIIYRDLKLNNVML-------NSEGHIKIADFG 482
>ATG1_CANAL (Q5A649) Serine/threonine-protein kinase ATG1 (EC 2.7.11.1)| (Autophagy-related protein 1) Length = 834 Score = 57.0 bits (136), Expect = 4e-08 Identities = 45/181 (24%), Positives = 76/181 (41%), Gaps = 32/181 (17%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 F V++C + +A A+K E EIE ++ L + +P +V + + Sbjct: 69 FATVYKCIDTTNNKAVAIKSVYRSKLKSKKLLENLEIEIQI--LKSMKHPHIVGLLDYKQ 126 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADI---------------------VA 385 S+ H+VMD CS DL ++R R PV + + + Sbjct: 127 TTSYFHLVMDYCSMGDLSYFIRRRNNLVKSHPVISSLLHRYPSPEGSHGLNEVLVLHFLR 186 Query: 386 QLAQALALCHRRGVIHRDVKPDNVVL-----------DVDDEGENGSPRARLADFGSAAW 532 QL+ AL + ++HRD+KP N++L D + G P ++ADFG A + Sbjct: 187 QLSSALQFLRDKSLVHRDIKPQNLLLCPPVHSKQEFIDGEFVGMWELPILKIADFGFARF 246 Query: 533 I 535 + Sbjct: 247 L 247
>KPCE_MOUSE (P16054) Protein kinase C epsilon type (EC 2.7.11.13)| (nPKC-epsilon) Length = 737 Score = 57.0 bits (136), Expect = 4e-08 Identities = 44/174 (25%), Positives = 74/174 (42%), Gaps = 4/174 (2%) Frame = +2 Query: 11 PEENH*TMSGELNR----DYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKXXXXXXXXXXX 178 P EN G+ R ++ FG V + E +AVK Sbjct: 389 PGENGEVRPGQAKRLGLDEFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDD 448 Query: 179 XXELAEIEPKLAQLAAAGNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVP 358 + E ++ LA +P + Q++ ++ VM+ +G DL+ +++R Sbjct: 449 DVDCTMTEKRILALARK-HPYLTQLYCCFQTKDRLFFVMEYVNGGDLM--FQIQRSRKFD 505 Query: 359 EPVAADIVAQLAQALALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFG 520 EP + A++ AL H+ GVI+RD+K DN++LD + +LADFG Sbjct: 506 EPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEG-------HCKLADFG 552
>AAPK1_RAT (P54645) 5'-AMP-activated protein kinase catalytic subunit alpha-1| (EC 2.7.11.1) (AMPK alpha-1 chain) Length = 548 Score = 57.0 bits (136), Expect = 4e-08 Identities = 40/144 (27%), Positives = 66/144 (45%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 FG V TG AVK + +I ++ L +P +++++ V Sbjct: 27 FGKVKVGKHELTGHKVAVKILNRQKIRSLDV--VGKIRREIQNLKLFRHPHIIKLYQVIS 84 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 S MVM+ SG +L D++ + + E + + Q+ + CHR V+HRD+KP Sbjct: 85 TPSDIFMVMEYVSGGELFDYIC--KNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKP 142 Query: 449 DNVVLDVDDEGENGSPRARLADFG 520 +NV+LD A++ADFG Sbjct: 143 ENVLLD-------AHMNAKIADFG 159
>AAPK1_MOUSE (Q5EG47) 5'-AMP-activated protein kinase catalytic subunit alpha-1| (EC 2.7.11.1) (AMPK alpha-1 chain) Length = 548 Score = 57.0 bits (136), Expect = 4e-08 Identities = 40/144 (27%), Positives = 66/144 (45%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 FG V TG AVK + +I ++ L +P +++++ V Sbjct: 27 FGKVKVGKHELTGHKVAVKILNRQKIRSLDV--VGKIRREIQNLKLFRHPHIIKLYQVIS 84 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 S MVM+ SG +L D++ + + E + + Q+ + CHR V+HRD+KP Sbjct: 85 TPSDIFMVMEYVSGGELFDYIC--KNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKP 142 Query: 449 DNVVLDVDDEGENGSPRARLADFG 520 +NV+LD A++ADFG Sbjct: 143 ENVLLD-------AHMNAKIADFG 159
>UNC51_CAEEL (Q23023) Serine/threonine-protein kinase unc-51 (EC 2.7.11.1)| (Uncoordinated protein 51) Length = 856 Score = 57.0 bits (136), Expect = 4e-08 Identities = 33/112 (29%), Positives = 62/112 (55%), Gaps = 3/112 (2%) Frame = +2 Query: 209 LAQLAAAGNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQ 388 L +L++ + +V + E + ++VM+ C+G DL D+ L++ + E V Q Sbjct: 60 LKELSSLKHENLVGLLKCTETPTHVYLVMEFCNGGDLADY--LQQKTTLNEDTIQHFVVQ 117 Query: 389 LAQALALCHRRGVIHRDVKPDNVVLDVDDEGEN---GSPRARLADFGSAAWI 535 +A AL +++G++HRD+KP N++L + +N +LADFG A ++ Sbjct: 118 IAHALEAINKKGIVHRDLKPQNILLCNNSRTQNPHFTDIVIKLADFGFARFL 169
>ST17A_RABIT (Q9GM70) Serine/threonine-protein kinase 17A (EC 2.7.11.1) (DAP| kinase-related apoptosis-inducing protein kinase 1) (rDRAK1) Length = 397 Score = 57.0 bits (136), Expect = 4e-08 Identities = 38/144 (26%), Positives = 65/144 (45%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 F VV +C + +G+ FA K E+ E + +LA NP V+ +H VYE Sbjct: 55 FAVVRKCIQKDSGKEFAAKFMRKRRKGQDCRMEIIH-EIAVLELAQ-DNPWVINLHEVYE 112 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 S +V++ +G ++ D R E ++ Q+ + + H V+H D+KP Sbjct: 113 TSSEMILVLEYAAGGEISDQCVADRDEAFNEKDVQRLMRQILEGVHFLHTHDVVHLDLKP 172 Query: 449 DNVVLDVDDEGENGSPRARLADFG 520 N++L E+ ++ DFG Sbjct: 173 QNILL----TSESPLGDIKIVDFG 192
>ATG1_DEBHA (Q6BS08) Serine/threonine-protein kinase ATG1 (EC 2.7.11.1)| (Autophagy-related protein 1) Length = 875 Score = 57.0 bits (136), Expect = 4e-08 Identities = 47/181 (25%), Positives = 75/181 (41%), Gaps = 32/181 (17%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 F V++C + T E+ A+K E EIE ++ L +P +V + + Sbjct: 33 FATVYKCFNTKTNESVAIKSVVRSKLKSKKLVENLEIE--ISILKTMKHPHIVGLLDYKQ 90 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVA--------------------- 385 S H+VMD CS DL ++R R PV + ++ Sbjct: 91 TTSHFHLVMDYCSMGDLSYFIRKRNQLIKTHPVISSLLERYPSPEGSHGLNEVLVIHFLK 150 Query: 386 QLAQALALCHRRGVIHRDVKPDNVVL--------DVDDEGENG---SPRARLADFGSAAW 532 QL AL + ++HRD+KP N++L + D G G P ++ADFG A + Sbjct: 151 QLVSALEFLRNKSLVHRDIKPQNLLLCPPLHSKQEFKDGGFVGLWELPLLKIADFGFARF 210 Query: 533 I 535 + Sbjct: 211 L 211
>CDPK4_PLAYO (Q7RJG2) Calcium-dependent protein kinase 4 (EC 2.7.11.1)| Length = 527 Score = 57.0 bits (136), Expect = 4e-08 Identities = 38/158 (24%), Positives = 75/158 (47%) Frame = +2 Query: 47 NRDYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAA 226 N Y FG V + TG +A+K + E +L ++ Sbjct: 66 NEQYKGIKILGKGSFGEVILSKDKHTGHEYAIKVISKKHVKRKTDKQSLLREVELLKMLD 125 Query: 227 AGNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALA 406 N +++++ +ED+++ ++V D+ SG +L D + R+ E AA I+ Q+ + Sbjct: 126 HIN--IMKLYEFFEDNNYYYLVSDVYSGGELFDEIISRKR--FYEVDAARIIKQVLSGIT 181 Query: 407 LCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFG 520 H+ V+HRD+KP+N++L+ ++ + ++ DFG Sbjct: 182 YMHKNNVVHRDLKPENILLETKNKED---MIIKIIDFG 216
>CDPK4_PLAF7 (Q8IBS5) Calcium-dependent protein kinase 4 (EC 2.7.11.1)| Length = 527 Score = 57.0 bits (136), Expect = 4e-08 Identities = 38/158 (24%), Positives = 75/158 (47%) Frame = +2 Query: 47 NRDYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAA 226 N Y FG V + TG +A+K E E +L ++ Sbjct: 66 NEQYKGIKILGKGSFGEVILSRDKHTGHEYAIKVISKKHVKRKTDKESLLREVELLKMLD 125 Query: 227 AGNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALA 406 N +++++ +ED+++ ++V D+ +G +L D + R+ E AA I+ Q+ + Sbjct: 126 HIN--IMKLYEFFEDNNYYYLVSDVYTGGELFDEIISRKR--FYEIDAARIIKQILSGIT 181 Query: 407 LCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFG 520 H+ V+HRD+KP+N++L+ ++ + ++ DFG Sbjct: 182 YMHKNNVVHRDLKPENILLETKNKED---MIIKIIDFG 216
>CDPK4_PLABA (P62345) Calcium-dependent protein kinase 4 (EC 2.7.11.1) (PbCDPK4)| Length = 527 Score = 57.0 bits (136), Expect = 4e-08 Identities = 38/158 (24%), Positives = 75/158 (47%) Frame = +2 Query: 47 NRDYXXXXXXXXXXFGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAA 226 N Y FG V + TG +A+K + E +L ++ Sbjct: 66 NEQYKGIKILGKGSFGEVILSKDKHTGHEYAIKVISKKHVKRKTDKQSLLREVELLKMLD 125 Query: 227 AGNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALA 406 N +++++ +ED+++ ++V D+ SG +L D + R+ E AA I+ Q+ + Sbjct: 126 HIN--IMKLYEFFEDNNYYYLVSDVYSGGELFDEIISRKR--FYEVDAARIIKQVLSGIT 181 Query: 407 LCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFG 520 H+ V+HRD+KP+N++L+ ++ + ++ DFG Sbjct: 182 YMHKNNVVHRDLKPENILLETKNKED---MIIKIIDFG 216
>AAPK1_PONPY (Q5RDH5) 5'-AMP-activated protein kinase catalytic subunit alpha-1| (EC 2.7.11.1) (AMPK alpha-1 chain) Length = 550 Score = 57.0 bits (136), Expect = 4e-08 Identities = 40/144 (27%), Positives = 66/144 (45%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 FG V TG AVK + +I ++ L +P +++++ V Sbjct: 29 FGKVKVGKHELTGHKVAVKILNRQKIRSLDV--VGKIRREIQNLKLFRHPHIIKLYQVIS 86 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 S MVM+ SG +L D++ + + E + + Q+ + CHR V+HRD+KP Sbjct: 87 TPSDIFMVMEYVSGGELFDYIC--KNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKP 144 Query: 449 DNVVLDVDDEGENGSPRARLADFG 520 +NV+LD A++ADFG Sbjct: 145 ENVLLD-------AHMNAKIADFG 161
>AAPK1_HUMAN (Q13131) 5'-AMP-activated protein kinase catalytic subunit alpha-1| (EC 2.7.11.1) (AMPK alpha-1 chain) Length = 550 Score = 57.0 bits (136), Expect = 4e-08 Identities = 40/144 (27%), Positives = 66/144 (45%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 FG V TG AVK + +I ++ L +P +++++ V Sbjct: 29 FGKVKVGKHELTGHKVAVKILNRQKIRSLDV--VGKIRREIQNLKLFRHPHIIKLYQVIS 86 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 S MVM+ SG +L D++ + + E + + Q+ + CHR V+HRD+KP Sbjct: 87 TPSDIFMVMEYVSGGELFDYIC--KNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKP 144 Query: 449 DNVVLDVDDEGENGSPRARLADFG 520 +NV+LD A++ADFG Sbjct: 145 ENVLLD-------AHMNAKIADFG 161
>ST17B_RAT (Q91XS8) Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP| kinase-related apoptosis-inducing protein kinase 2) Length = 371 Score = 56.6 bits (135), Expect = 5e-08 Identities = 40/152 (26%), Positives = 73/152 (48%), Gaps = 2/152 (1%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGN-PGVVQVHAVY 265 F VV +C S+STG+ +A K AEI ++A L A + P V+ +H VY Sbjct: 44 FAVVRQCISKSTGQEYAAKFLKKRRRGQDCR---AEILHEIAVLELARSCPHVINLHEVY 100 Query: 266 EDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVK 445 E + +V++ +G ++ + V E ++ Q+ + + H+ ++H D+K Sbjct: 101 ETATEIILVLEYAAGGEIFNLCLPELAEMVSENDVIRLIKQILEGVHYLHQNNIVHLDLK 160 Query: 446 PDNVVL-DVDDEGENGSPRARLADFGSAAWIG 538 P N++L + G+ ++ DFG + IG Sbjct: 161 PQNILLSSIYPLGD-----IKIVDFGMSRKIG 187
>KKK1_YEAST (P34244) Probable serine/threonine-protein kinase YKL101W (EC| 2.7.11.1) Length = 1518 Score = 56.6 bits (135), Expect = 5e-08 Identities = 31/111 (27%), Positives = 60/111 (54%) Frame = +2 Query: 197 IEPKLAQLAAAGNPGVVQVHAVYEDDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAAD 376 IE ++ + + V+ + V+E+ S ++V++ G +L D++ + +PE A Sbjct: 161 IEREIVIMKLISHTNVMALFEVWENKSELYLVLEYVDGGELFDYLVSK--GKLPEREAIH 218 Query: 377 IVAQLAQALALCHRRGVIHRDVKPDNVVLDVDDEGENGSPRARLADFGSAA 529 Q+ + ++ CH + HRD+KP+N++LD + R ++ADFG AA Sbjct: 219 YFKQIVEGVSYCHSFNICHRDLKPENLLLDKKNR------RIKIADFGMAA 263
>STK10_HUMAN (O94804) Serine/threonine-protein kinase 10 (EC 2.7.11.1)| (Lymphocyte-oriented kinase) Length = 968 Score = 56.6 bits (135), Expect = 5e-08 Identities = 39/147 (26%), Positives = 69/147 (46%) Frame = +2 Query: 89 FGVVHRCTSRSTGEAFAVKXXXXXXXXXXXXXELAEIEPKLAQLAAAGNPGVVQVHAVYE 268 FG V++ ++ TG A K EL + ++ LA +P +V++ Y Sbjct: 47 FGKVYKAKNKETGALAAAKVIETKSEE-----ELEDYIVEIEILATCDHPYIVKLLGAYY 101 Query: 269 DDSWTHMVMDLCSGPDLLDWVRLRRGAPVPEPVAADIVAQLAQALALCHRRGVIHRDVKP 448 D ++++ C G +D + L + EP + Q+ +AL H + +IHRD+K Sbjct: 102 HDGKLWIMIEFCPG-GAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLHSKRIIHRDLKA 160 Query: 449 DNVVLDVDDEGENGSPRARLADFGSAA 529 NV++ ++ + RLADFG +A Sbjct: 161 GNVLMTLEGD-------IRLADFGVSA 180 Database: uniprot_sprot.fasta Posted date: May 25, 2006 5:36 PM Number of letters in database: 80,573,946 Number of sequences in database: 219,361 Lambda K H 0.315 0.129 0.399 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 38,490,782 Number of Sequences: 219361 Number of extensions: 643775 Number of successful extensions: 4859 Number of sequences better than 10.0: 500 Number of HSP's better than 10.0 without gapping: 4364 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 4545 length of database: 80,573,946 effective HSP length: 106 effective length of database: 57,321,680 effective search space used: 4585734400 frameshift window, decay const: 50, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.6 bits)
