>DERL2_PONPY (Q5RC74) Derlin-2 (Degradation in endoplasmic reticulum protein 2)|
           (Der1-like protein 2)
          Length = 239

 Score =  124 bits (310), Expect = 3e-28
 Identities = 61/139 (43%), Positives = 86/139 (61%)
 Frame = +3

Query: 177 QAVEEWYRQMPIITRSYLTAAVLTTVGCTLEIISPYHLYLNPKLVVQHYEIWRLVTNFLY 356
           Q++   Y Q+P ++R+Y TA VLTT    LE+I+P+ LY NP+L+ +H++IWRL+TNFL+
Sbjct: 4   QSLRLEYLQIPPVSRAYTTACVLTTAAVQLELITPFQLYFNPELIFKHFQIWRLITNFLF 63

Query: 357 FRKXXXXXXXXXXXXARYCKLLEENSFRGRTADFFYMLLFGATVLTSIVLIGGTIPYISE 536
           F               RYC++LEE SFRGRTADF +M LFG  ++T   L          
Sbjct: 64  FGPVGFNFLFNMIFLYRYCRMLEEGSFRGRTADFVFMFLFGGFLMTLFGL---------- 113

Query: 537 TFVRILFLSNSLTFMMVYV 593
            FV ++FL  + T M+VYV
Sbjct: 114 -FVSLVFLGQAFTIMLVYV 131

>DERL2_MOUSE (Q8BNI4) Derlin-2 (Degradation in endoplasmic reticulum protein 2)|
           (Der1-like protein 2) (F-LANa)
          Length = 239

 Score =  124 bits (310), Expect = 3e-28
 Identities = 61/139 (43%), Positives = 86/139 (61%)
 Frame = +3

Query: 177 QAVEEWYRQMPIITRSYLTAAVLTTVGCTLEIISPYHLYLNPKLVVQHYEIWRLVTNFLY 356
           Q++   Y Q+P ++R+Y TA VLTT    LE+I+P+ LY NP+L+ +H++IWRL+TNFL+
Sbjct: 4   QSLRLEYLQIPPVSRAYTTACVLTTAAVQLELITPFQLYFNPELIFKHFQIWRLITNFLF 63

Query: 357 FRKXXXXXXXXXXXXARYCKLLEENSFRGRTADFFYMLLFGATVLTSIVLIGGTIPYISE 536
           F               RYC++LEE SFRGRTADF +M LFG  ++T   L          
Sbjct: 64  FGPVGFNFLFNMIFLYRYCRMLEEGSFRGRTADFVFMFLFGGFLMTLFGL---------- 113

Query: 537 TFVRILFLSNSLTFMMVYV 593
            FV ++FL  + T M+VYV
Sbjct: 114 -FVSLVFLGQAFTIMLVYV 131

>DERL2_HUMAN (Q9GZP9) Derlin-2 (Degradation in endoplasmic reticulum protein 2)|
           (Der1-like protein 2) (DERtrin-2) (F-LANa) (F-LAN-1)
          Length = 239

 Score =  124 bits (310), Expect = 3e-28
 Identities = 61/139 (43%), Positives = 86/139 (61%)
 Frame = +3

Query: 177 QAVEEWYRQMPIITRSYLTAAVLTTVGCTLEIISPYHLYLNPKLVVQHYEIWRLVTNFLY 356
           Q++   Y Q+P ++R+Y TA VLTT    LE+I+P+ LY NP+L+ +H++IWRL+TNFL+
Sbjct: 4   QSLRLEYLQIPPVSRAYTTACVLTTAAVQLELITPFQLYFNPELIFKHFQIWRLITNFLF 63

Query: 357 FRKXXXXXXXXXXXXARYCKLLEENSFRGRTADFFYMLLFGATVLTSIVLIGGTIPYISE 536
           F               RYC++LEE SFRGRTADF +M LFG  ++T   L          
Sbjct: 64  FGPVGFNFLFNMIFLYRYCRMLEEGSFRGRTADFVFMFLFGGFLMTLFGL---------- 113

Query: 537 TFVRILFLSNSLTFMMVYV 593
            FV ++FL  + T M+VYV
Sbjct: 114 -FVSLVFLGQAFTIMLVYV 131

>DERL3_HUMAN (Q96Q80) Derlin-3 (Degradation in endoplasmic reticulum protein 3)|
           (Der1-like protein 3) (DERtrin-3)
          Length = 235

 Score =  119 bits (297), Expect = 9e-27
 Identities = 59/139 (42%), Positives = 82/139 (58%)
 Frame = +3

Query: 177 QAVEEWYRQMPIITRSYLTAAVLTTVGCTLEIISPYHLYLNPKLVVQHYEIWRLVTNFLY 356
           Q +   + Q+P +TR+Y  A VLTT    LE++SP+ LY NP LV + +++WRLVTNFL+
Sbjct: 4   QGLAAEFLQVPAVTRAYTAACVLTTAAVQLELLSPFQLYFNPHLVFRKFQVWRLVTNFLF 63

Query: 357 FRKXXXXXXXXXXXXARYCKLLEENSFRGRTADFFYMLLFGATVLTSIVLIGGTIPYISE 536
           F               RYC++LEE SFRGRTADF +M LFG  ++T + L+G        
Sbjct: 64  FGPLGFSFFFNMLFVFRYCRMLEEGSFRGRTADFVFMFLFGGVLMTLLGLLGS------- 116

Query: 537 TFVRILFLSNSLTFMMVYV 593
               + FL  +L  M+VYV
Sbjct: 117 ----LFFLGQALMAMLVYV 131

>DERL2_CAEEL (Q21997) Derlin-2 (DER1-like protein 2) (cDerlin-2)|
          Length = 237

 Score =  113 bits (283), Expect = 4e-25
 Identities = 59/142 (41%), Positives = 81/142 (57%)
 Frame = +3

Query: 168 GMAQAVEEWYRQMPIITRSYLTAAVLTTVGCTLEIISPYHLYLNPKLVVQHYEIWRLVTN 347
           G+  A+EE    MP +TR Y  A VL T    LE ++P+HLY N +L+++ Y+ WRL+T+
Sbjct: 3   GVVAALEE----MPPVTRFYTGACVLLTTAVHLEFVTPFHLYFNWELIIRKYQFWRLITS 58

Query: 348 FLYFRKXXXXXXXXXXXXARYCKLLEENSFRGRTADFFYMLLFGATVLTSIVLIGGTIPY 527
           F +F               RYC +LEE SFRGR ADF YM LFGA ++            
Sbjct: 59  FCFFGSFGFSFLFNMIFTYRYCMMLEEGSFRGRRADFVYMFLFGAVLM-----------I 107

Query: 528 ISETFVRILFLSNSLTFMMVYV 593
           +S  FV+ILFL  + T M+VY+
Sbjct: 108 LSGIFVQILFLGQAFTIMLVYI 129

>DERL3_MOUSE (Q9D8K3) Derlin-3 (Degradation in endoplasmic reticulum protein 3)|
           (Der1-like protein 3) (Protein IZP6)
          Length = 228

 Score =  112 bits (279), Expect = 1e-24
 Identities = 55/139 (39%), Positives = 79/139 (56%)
 Frame = +3

Query: 177 QAVEEWYRQMPIITRSYLTAAVLTTVGCTLEIISPYHLYLNPKLVVQHYEIWRLVTNFLY 356
           Q +   + Q+P +TR+Y  A VLTT    LE++SP+ LY NP LV + +++WRL+T FL+
Sbjct: 4   QRLAAGFLQVPAVTRAYTAACVLTTAAVQLELLSPFQLYFNPHLVFRKFQVWRLITTFLF 63

Query: 357 FRKXXXXXXXXXXXXARYCKLLEENSFRGRTADFFYMLLFGATVLTSIVLIGGTIPYISE 536
           F               RYC++LEE SFRGR ADF +M LFG  ++T +  +G        
Sbjct: 64  FGPLGFGFFFNMLFVFRYCRMLEEGSFRGRKADFVFMFLFGGVLMTLLGFLGS------- 116

Query: 537 TFVRILFLSNSLTFMMVYV 593
               + FL  +L  M+VYV
Sbjct: 117 ----LFFLGQALMAMLVYV 131

>DERL1_HUMAN (Q9BUN8) Derlin-1 (Degradation in endoplasmic reticulum protein 1)|
           (Der1-like protein 1) (DERtrin-1)
          Length = 251

 Score = 60.8 bits (146), Expect = 3e-09
 Identities = 35/113 (30%), Positives = 56/113 (49%), Gaps = 5/113 (4%)
 Frame = +3

Query: 183 VEEWYRQMPIITRSYLTAAVLTTVGCTLEIISPYHLYLNPKLVVQHYEIWRLVTNFLYF- 359
           + +W+R +P ITR +  A V   +   L +ISP +L+L P+  +  ++IWR +T   YF 
Sbjct: 4   IGDWFRSIPAITRYWFAATVAVPLVGKLGLISPAYLFLWPEAFLYRFQIWRPITATFYFP 63

Query: 360 --RKXXXXXXXXXXXXARYCKLLEENSFRGRTADFFYMLLFG--ATVLTSIVL 506
                            +Y   LE  +F GR AD+ +MLLF     V+T + +
Sbjct: 64  VGPGTGFLYLVNLYFLYQYSTRLETGAFDGRPADYLFMLLFNWICIVITGLAM 116

>DERL1_PONPY (Q5R9W3) Derlin-1 (Degradation in endoplasmic reticulum protein 1)|
           (Der1-like protein 1)
          Length = 251

 Score = 60.5 bits (145), Expect = 4e-09
 Identities = 35/113 (30%), Positives = 55/113 (48%), Gaps = 5/113 (4%)
 Frame = +3

Query: 183 VEEWYRQMPIITRSYLTAAVLTTVGCTLEIISPYHLYLNPKLVVQHYEIWRLVTNFLYF- 359
           + +W+R +P ITR +  A V   +   L +ISP +L+L P+  +  ++IWR +T   YF 
Sbjct: 4   IGDWFRSIPAITRYWFAATVAVPLVGKLGLISPAYLFLWPEAFLYRFQIWRPITATFYFP 63

Query: 360 --RKXXXXXXXXXXXXARYCKLLEENSFRGRTADFFYMLLFG--ATVLTSIVL 506
                             Y   LE  +F GR AD+ +MLLF     V+T + +
Sbjct: 64  VGPGTGFLYLVNLYFLYHYSTRLETGAFDGRPADYLFMLLFNWICIVITGLAM 116

>DERL1_BOVIN (Q71SS4) Derlin-1 (Degradation in endoplasmic reticulum protein 1)|
           (Der1-like protein 1)
          Length = 251

 Score = 59.3 bits (142), Expect = 8e-09
 Identities = 34/113 (30%), Positives = 55/113 (48%), Gaps = 5/113 (4%)
 Frame = +3

Query: 183 VEEWYRQMPIITRSYLTAAVLTTVGCTLEIISPYHLYLNPKLVVQHYEIWRLVTNFLYF- 359
           + +W+R +P ITR +  A V   +   L +ISP + +L P+  +  ++IWR +T   YF 
Sbjct: 4   IGDWFRSIPTITRYWFAATVAVPLVGKLGLISPAYFFLWPEAFLYRFQIWRPITATFYFP 63

Query: 360 --RKXXXXXXXXXXXXARYCKLLEENSFRGRTADFFYMLLFG--ATVLTSIVL 506
                            +Y   LE  +F GR AD+ +MLLF     V+T + +
Sbjct: 64  VGPGTGFLYLVNLYFLYQYSTRLETGAFDGRPADYLFMLLFNWICIVITGLAM 116

>DERL1_MOUSE (Q99J56) Derlin-1 (Degradation in endoplasmic reticulum protein 1)|
           (Der1-like protein 1)
          Length = 251

 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 35/113 (30%), Positives = 54/113 (47%), Gaps = 5/113 (4%)
 Frame = +3

Query: 183 VEEWYRQMPIITRSYLTAAVLTTVGCTLEIISPYHLYLNPKLVVQHYEIWRLVTNFLYF- 359
           + +W+R +P ITR +  A V   +   L IISP + +L P+  +  ++IWR  T   YF 
Sbjct: 4   IGDWFRSIPAITRYWFAATVAVPLIGKLGIISPAYFFLWPEAFLYRFQIWRPFTATFYFP 63

Query: 360 --RKXXXXXXXXXXXXARYCKLLEENSFRGRTADFFYMLLFG--ATVLTSIVL 506
                            +Y   LE  +F GR AD+ +MLLF     V+T + +
Sbjct: 64  VGPGTGFLYLVNLYFLYQYSTRLEAGAFDGRPADYLFMLLFNWICIVITGLAM 116

>DERL1_DROME (Q9VQ57) Derlin-1 (DER1-like protein 1)|
          Length = 245

 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 35/137 (25%), Positives = 62/137 (45%), Gaps = 3/137 (2%)
 Frame = +3

Query: 192 WYRQMPIITRSYLTAAVLTTVGCTLEIISPYHLYLNPKLVVQHYEIWRLVTNFLYF---R 362
           WYR +P  TR +LTA V+ ++ C  ++I  + L+L+   V    ++WR +T+   F    
Sbjct: 6   WYRSLPRFTRYWLTATVVLSMLCRFDVIPLHWLHLDRSAVFSKLQLWRCMTSLFVFPISS 65

Query: 363 KXXXXXXXXXXXXARYCKLLEENSFRGRTADFFYMLLFGATVLTSIVLIGGTIPYISETF 542
                         +Y   LE++ +    AD+ Y+L+  A +      IGG I       
Sbjct: 66  NTAFHFLINCFFIVQYSSKLEKDQYSRSPADYLYLLIVSAVLAN----IGGMI------- 114

Query: 543 VRILFLSNSLTFMMVYV 593
             + FL ++L   + Y+
Sbjct: 115 FNVYFLMDTLVLAITYI 131

>DERL1_CAEEL (Q93561) Derlin-1 (DER1-like protein 1) (cDerlin-1)|
          Length = 245

 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 27/101 (26%), Positives = 50/101 (49%), Gaps = 3/101 (2%)
 Frame = +3

Query: 183 VEEWYRQMPIITRSYLTAAVLTTVGCTLEIISPYHLYLNPKLVVQHYEIWRLVTNFLYFR 362
           +E +   +PI+TR +  A+ +  +      I+   ++L   LVV  ++ WR +T  +Y+ 
Sbjct: 3   LENFLLGIPIVTRYWFLASTIIPLLGRFGFINVQWMFLQWDLVVNKFQFWRPLTALIYYP 62

Query: 363 ---KXXXXXXXXXXXXARYCKLLEENSFRGRTADFFYMLLF 476
              +              Y K LE  ++RGR+AD+ +ML+F
Sbjct: 63  VTPQTGFHWLMMCYFLYNYSKALESETYRGRSADYLFMLIF 103

>DFM1_YEAST (Q12743) DER1-like family member protein 1|
          Length = 341

 Score = 38.5 bits (88), Expect = 0.015
 Identities = 29/117 (24%), Positives = 49/117 (41%), Gaps = 9/117 (7%)
 Frame = +3

Query: 186 EEWYRQMPIITRSYLTAAVLTTVGCTLEIISPYHLYLNPKLVVQHYEIWRLVTNFLYFRK 365
           +E++  +P ITR+  T A++ T+   L +I+P++      L  +  +IWRL+T+ +    
Sbjct: 24  KEFWLNIPPITRTLFTLAIVMTIVGRLNLINPWYFIYVWNLTFKKVQIWRLLTSCVMLSS 83

Query: 366 XXXXXXXXXXXXARYCKLLEENSF-------RGR--TADFFYMLLFGATVLTSIVLI 509
                             LE   F       RG   T D+ Y L F    +T+   I
Sbjct: 84  RAMPALMELYSIYDRSSQLERGHFGPGLSNRRGPMVTVDYAYYLCFCILAITTATTI 140

>Y3846_ARATH (Q8LB17) Protein At3g58460|
          Length = 403

 Score = 30.8 bits (68), Expect = 3.1
 Identities = 16/73 (21%), Positives = 34/73 (46%), Gaps = 1/73 (1%)
 Frame = +3

Query: 141 PRVVGEESAGMAQAVEEWYRQMPIITRSYLTAAVLTTVGCTLEIISP-YHLYLNPKLVVQ 317
           P +V E  AG+   V +W+  +P +T S +    +  + C L      Y +   P  ++ 
Sbjct: 3   PNIVTE--AGVQTRVGQWWNAIPFLTSSVVVVCGVIYLICLLTGYDTFYEVCFLPSAIIS 60

Query: 318 HYEIWRLVTNFLY 356
            ++++R  T  ++
Sbjct: 61  RFQVYRFYTAIIF 73

>SKI_CHICK (P49140) Ski oncogene (C-ski)|
          Length = 750

 Score = 29.6 bits (65), Expect = 6.9
 Identities = 17/32 (53%), Positives = 22/32 (68%), Gaps = 1/32 (3%)
 Frame = +2

Query: 53  SAGDPSTPAQPRERR-AVE*PAVARPGARVSA 145
           S+  PS+ AQPR+R+ A E PAV  P A V+A
Sbjct: 461 SSEPPSSAAQPRKRKHAAETPAVPEPVATVTA 492


  Database: uniprot_sprot.fasta
    Posted date:  May 25, 2006  5:36 PM
  Number of letters in database: 80,573,946
  Number of sequences in database:  219,361
  
Lambda     K      H
   0.318    0.135    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 62,836,003
Number of Sequences: 219361
Number of extensions: 1089485
Number of successful extensions: 3796
Number of sequences better than 10.0: 15
Number of HSP's better than 10.0 without gapping: 3670
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3779
length of database: 80,573,946
effective HSP length: 106
effective length of database: 57,321,680
effective search space used: 5216272880
frameshift window, decay const: 50,  0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)