ナショナルバイオリソースプロジェクト
-Barley Genetic Resources Database-
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| Clone Name | baet07f03 |
|---|---|
| Clone Library Name | barley_pub |
>HT1_ARATH (Q2MHE4) Serine/threonine-protein kinase HT1 (EC 2.7.11.1) (High| leaf temperature protein 1) Length = 390 Score = 163 bits (412), Expect = 2e-40 Identities = 72/140 (51%), Positives = 103/140 (73%) Frame = +2 Query: 2 KFVGACRKPIVWCIVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGF 181 +F+ AC+KP V+CI+T Y G++R +LN+++ S+ ++ ++ ALD++RGM Y+H G Sbjct: 149 QFIAACKKPPVYCIITEYMSQGNLRMYLNKKEPYSLSIETVLRLALDISRGMEYLHSQGV 208 Query: 182 IHRDLKSDNLLISGDKSIKIADFGVARIEVKTEGMTPETGTYRWMAPEMIQHRPYNQKVD 361 IHRDLKS+NLL++ + +K+ADFG + +E + GTYRWMAPEMI+ +PY +KVD Sbjct: 209 IHRDLKSNNLLLNDEMRVKVADFGTSCLETQCREAKGNMGTYRWMAPEMIKEKPYTRKVD 268 Query: 362 VYSFGIVLWELITGTLPFLG 421 VYSFGIVLWEL T LPF G Sbjct: 269 VYSFGIVLWELTTALLPFQG 288
>MLTK_MOUSE (Q9ESL4) Mitogen-activated protein kinase kinase kinase MLT (EC| 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper-and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) ( Length = 802 Score = 113 bits (283), Expect = 2e-25 Identities = 60/146 (41%), Positives = 91/146 (62%), Gaps = 3/146 (2%) Frame = +2 Query: 2 KFVGACRKPIVWCIVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVH---G 172 +F G +P + IVT YA GS+ +++N ++ + ++ + A DVA+GM Y+H Sbjct: 67 QFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMEHIMTWATDVAKGMHYLHMEAP 126 Query: 173 LGFIHRDLKSDNLLISGDKSIKIADFGVARIEVKTEGMTPETGTYRWMAPEMIQHRPYNQ 352 + IHRDLKS N++I+ D +KI DFG +R T M+ GT+ WMAPE+IQ P ++ Sbjct: 127 VKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSL-VGTFPWMAPEVIQSLPVSE 185 Query: 353 KVDVYSFGIVLWELITGTLPFLGGRG 430 D YS+G+VLWE++T +PF G G Sbjct: 186 TCDTYSYGVVLWEMLTREVPFKGLEG 211
>MLTK_HUMAN (Q9NYL2) Mitogen-activated protein kinase kinase kinase MLT (EC| 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper-and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase Length = 800 Score = 112 bits (281), Expect = 3e-25 Identities = 60/146 (41%), Positives = 90/146 (61%), Gaps = 3/146 (2%) Frame = +2 Query: 2 KFVGACRKPIVWCIVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVH---G 172 +F G +P + IVT YA GS+ +++N ++ + + + A DVA+GM Y+H Sbjct: 67 QFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAP 126 Query: 173 LGFIHRDLKSDNLLISGDKSIKIADFGVARIEVKTEGMTPETGTYRWMAPEMIQHRPYNQ 352 + IHRDLKS N++I+ D +KI DFG +R T M+ GT+ WMAPE+IQ P ++ Sbjct: 127 VKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSL-VGTFPWMAPEVIQSLPVSE 185 Query: 353 KVDVYSFGIVLWELITGTLPFLGGRG 430 D YS+G+VLWE++T +PF G G Sbjct: 186 TCDTYSYGVVLWEMLTREVPFKGLEG 211
>M3K10_HUMAN (Q02779) Mitogen-activated protein kinase kinase kinase 10 (EC| 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST) Length = 954 Score = 110 bits (274), Expect = 2e-24 Identities = 65/146 (44%), Positives = 88/146 (60%), Gaps = 11/146 (7%) Frame = +2 Query: 11 GACRKPIVWCIVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHG---LGF 181 GAC P C+V YA+GG++ L R VP + V A+ VARGM Y+H + Sbjct: 162 GACLNPPHLCLVMEYARGGALSRVL---AGRRVPPHVLVNWAVQVARGMNYLHNDAPVPI 218 Query: 182 IHRDLKSDNLLIS--------GDKSIKIADFGVARIEVKTEGMTPETGTYRWMAPEMIQH 337 IHRDLKS N+LI D +KI DFG+AR KT M+ GTY WMAPE+I+ Sbjct: 219 IHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHKTTKMSA-AGTYAWMAPEVIRL 277 Query: 338 RPYNQKVDVYSFGIVLWELITGTLPF 415 +++ DV+SFG++LWEL+TG +P+ Sbjct: 278 SLFSKSSDVWSFGVLLWELLTGEVPY 303
>M3K13_HUMAN (O43283) Mitogen-activated protein kinase kinase kinase 13 (EC| 2.7.11.25) (Mixed lineage kinase) (MLK) (Leucine zipper-bearing kinase) Length = 966 Score = 110 bits (274), Expect = 2e-24 Identities = 54/137 (39%), Positives = 82/137 (59%) Frame = +2 Query: 5 FVGACRKPIVWCIVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFI 184 F G C + +CI+ Y G + L R R + +L V + +A GM Y+H I Sbjct: 219 FKGVCTQAPCYCIIMEYCAHGQLYEVL--RAGRKITPRLLVDWSTGIASGMNYLHLHKII 276 Query: 185 HRDLKSDNLLISGDKSIKIADFGVARIEVKTEGMTPETGTYRWMAPEMIQHRPYNQKVDV 364 HRDLKS N+L++ ++KI+DFG ++ GT WMAPE+I++ P ++KVD+ Sbjct: 277 HRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDI 336 Query: 365 YSFGIVLWELITGTLPF 415 +SFG+VLWEL+TG +P+ Sbjct: 337 WSFGVVLWELLTGEIPY 353
>M3K12_RAT (Q63796) Mitogen-activated protein kinase kinase kinase 12 (EC| 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK) Length = 888 Score = 109 bits (273), Expect = 3e-24 Identities = 56/137 (40%), Positives = 82/137 (59%) Frame = +2 Query: 5 FVGACRKPIVWCIVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFI 184 F G C + +CI+ + G + L R R V L V ++ +A GM Y+H I Sbjct: 209 FKGVCTQAPCYCILMEFCAQGQLYEVL--RAGRPVTPSLLVDWSMGIAGGMNYLHLHKII 266 Query: 185 HRDLKSDNLLISGDKSIKIADFGVARIEVKTEGMTPETGTYRWMAPEMIQHRPYNQKVDV 364 HRDLKS N+LI+ D +KI+DFG ++ GT WMAPE+I++ P ++KVD+ Sbjct: 267 HRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDI 326 Query: 365 YSFGIVLWELITGTLPF 415 +SFG+VLWEL+TG +P+ Sbjct: 327 WSFGVVLWELLTGEIPY 343
>M3K12_MOUSE (Q60700) Mitogen-activated protein kinase kinase kinase 12 (EC| 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK) Length = 888 Score = 109 bits (273), Expect = 3e-24 Identities = 56/137 (40%), Positives = 82/137 (59%) Frame = +2 Query: 5 FVGACRKPIVWCIVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFI 184 F G C + +CI+ + G + L R R V L V ++ +A GM Y+H I Sbjct: 209 FKGVCTQAPCYCILMEFCAQGQLYEVL--RAGRPVTPSLLVDWSMGIAGGMNYLHLHKII 266 Query: 185 HRDLKSDNLLISGDKSIKIADFGVARIEVKTEGMTPETGTYRWMAPEMIQHRPYNQKVDV 364 HRDLKS N+LI+ D +KI+DFG ++ GT WMAPE+I++ P ++KVD+ Sbjct: 267 HRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDI 326 Query: 365 YSFGIVLWELITGTLPF 415 +SFG+VLWEL+TG +P+ Sbjct: 327 WSFGVVLWELLTGEIPY 343
>M3K12_HUMAN (Q12852) Mitogen-activated protein kinase kinase kinase 12 (EC| 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK) Length = 859 Score = 109 bits (273), Expect = 3e-24 Identities = 56/137 (40%), Positives = 82/137 (59%) Frame = +2 Query: 5 FVGACRKPIVWCIVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFI 184 F G C + +CI+ + G + L R R V L V ++ +A GM Y+H I Sbjct: 176 FKGVCTQAPCYCILMEFCAQGQLYEVL--RAGRPVTPSLLVDWSMGIAGGMNYLHLHKII 233 Query: 185 HRDLKSDNLLISGDKSIKIADFGVARIEVKTEGMTPETGTYRWMAPEMIQHRPYNQKVDV 364 HRDLKS N+LI+ D +KI+DFG ++ GT WMAPE+I++ P ++KVD+ Sbjct: 234 HRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDI 293 Query: 365 YSFGIVLWELITGTLPF 415 +SFG+VLWEL+TG +P+ Sbjct: 294 WSFGVVLWELLTGEIPY 310
>M3K13_PONPY (Q5R8X7) Mitogen-activated protein kinase kinase kinase 13 (EC| 2.7.11.25) Length = 966 Score = 108 bits (271), Expect = 4e-24 Identities = 53/137 (38%), Positives = 82/137 (59%) Frame = +2 Query: 5 FVGACRKPIVWCIVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFI 184 F G C + +CI+ Y G + L R R + +L V + +A GM Y+H I Sbjct: 219 FKGVCTQAPCYCIIMEYCAHGQLYEVL--RAGRKITPRLLVDWSTGIASGMNYLHLHKII 276 Query: 185 HRDLKSDNLLISGDKSIKIADFGVARIEVKTEGMTPETGTYRWMAPEMIQHRPYNQKVDV 364 HRDLKS N+L++ ++KI+DFG ++ GT W+APE+I++ P ++KVD+ Sbjct: 277 HRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFAGTVAWLAPEVIRNEPVSEKVDI 336 Query: 365 YSFGIVLWELITGTLPF 415 +SFG+VLWEL+TG +P+ Sbjct: 337 WSFGVVLWELLTGEIPY 353
>M3K9_HUMAN (P80192) Mitogen-activated protein kinase kinase kinase 9 (EC| 2.7.11.25) (Mixed lineage kinase 1) Length = 1104 Score = 107 bits (267), Expect = 1e-23 Identities = 62/148 (41%), Positives = 92/148 (62%), Gaps = 11/148 (7%) Frame = +2 Query: 11 GACRKPIVWCIVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHG---LGF 181 G C K C+V +A+GG + L+ ++ +P + V A+ +ARGM Y+H + Sbjct: 208 GVCLKEPNLCLVMEFARGGPLNRVLSGKR---IPPDILVNWAVQIARGMNYLHDEAIVPI 264 Query: 182 IHRDLKSDNLLI-----SGD---KSIKIADFGVARIEVKTEGMTPETGTYRWMAPEMIQH 337 IHRDLKS N+LI +GD K +KI DFG+AR +T M+ GTY WMAPE+I+ Sbjct: 265 IHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSA-AGTYAWMAPEVIRA 323 Query: 338 RPYNQKVDVYSFGIVLWELITGTLPFLG 421 +++ DV+S+G++LWEL+TG +PF G Sbjct: 324 SMFSKGSDVWSYGVLLWELLTGEVPFRG 351
>KYK2_DICDI (P18161) Tyrosine-protein kinase 2 (EC 2.7.10.2) (Fragment)| Length = 410 Score = 107 bits (267), Expect = 1e-23 Identities = 57/145 (39%), Positives = 89/145 (61%), Gaps = 8/145 (5%) Frame = +2 Query: 5 FVGACRKPIVWCIVTGYAKGGSVRNFLNRRQNRSVPLK----LAVKQALDVARGMAYVHG 172 F+GAC KP CI+T Y GGS+ N L+ + + +K L +K A D+A G+ ++H Sbjct: 168 FIGACYKPA--CIITEYMAGGSLYNILHNPNSSTPKVKYSFPLVLKMATDMALGLLHLHS 225 Query: 173 LGFIHRDLKSDNLLISGDKSIKIADFGVARIEVKTEGMTPETG---TYRWMAPEMIQH-R 340 + +HRDL S N+L+ +IKI+DFG++ + + MT G RW PE+ ++ Sbjct: 226 ITIVHRDLTSQNILLDELGNIKISDFGLSAEKSREGSMTMTNGGICNPRWRPPELTKNLG 285 Query: 341 PYNQKVDVYSFGIVLWELITGTLPF 415 Y++KVDVY F +V+WE++TG +PF Sbjct: 286 HYSEKVDVYCFSLVVWEILTGEIPF 310
>M3KSL_DROME (Q95UN8) Mitogen-activated protein kinase kinase kinase (EC| 2.7.11.25) (Mixed lineage kinase) (dMLK) (Protein slipper) Length = 1161 Score = 106 bits (264), Expect = 3e-23 Identities = 61/139 (43%), Positives = 83/139 (59%), Gaps = 11/139 (7%) Frame = +2 Query: 38 CIVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHG---LGFIHRDLKSDN 208 C+V YA+GGS LNR +P + V A+ +ARGM Y+H + IHRDLKS N Sbjct: 214 CLVMEYARGGS----LNRILAGKIPPDVLVNWAIQIARGMNYLHNEAPMSIIHRDLKSSN 269 Query: 209 LLISG--------DKSIKIADFGVARIEVKTEGMTPETGTYRWMAPEMIQHRPYNQKVDV 364 +LI K++KI DFG+AR T+ M+ GTY WM PE+I Y++ DV Sbjct: 270 VLIYEAIEGNHLQQKTLKITDFGLAREMYNTQRMSA-AGTYAWMPPEVISVSTYSKFSDV 328 Query: 365 YSFGIVLWELITGTLPFLG 421 +S+G++LWELITG P+ G Sbjct: 329 WSYGVLLWELITGETPYKG 347
>TNI3K_RAT (Q7TQP6) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 834 Score = 105 bits (263), Expect = 4e-23 Identities = 63/144 (43%), Positives = 87/144 (60%), Gaps = 6/144 (4%) Frame = +2 Query: 2 KFVGACRK-PIVWCIVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLG 178 +FVGAC P + IVT Y GGS+ + L+ Q R + L+ + A+DVA+GM Y+H L Sbjct: 522 QFVGACLDDPSQFAIVTQYISGGSLFSLLHE-QKRILDLQSKLIIAVDVAKGMEYLHSLT 580 Query: 179 --FIHRDLKSDNLLISGDKSIKIADFGVARI--EVKTEGMTPETGTYRWMAPEMI-QHRP 343 IHRDL S N+L+ D +ADFG +R + + MT + G RWMAPE+ Q Sbjct: 581 QPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNLRWMAPEVFTQCTR 640 Query: 344 YNQKVDVYSFGIVLWELITGTLPF 415 Y K DV+S+ + LWEL+TG +PF Sbjct: 641 YTIKADVFSYSLCLWELLTGEIPF 664
>TNI3K_HUMAN (Q59H18) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 936 Score = 105 bits (263), Expect = 4e-23 Identities = 62/144 (43%), Positives = 87/144 (60%), Gaps = 6/144 (4%) Frame = +2 Query: 2 KFVGAC-RKPIVWCIVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLG 178 +FVGAC P + IVT Y GGS+ + L+ Q R + L+ + A+DVA+GM Y+H L Sbjct: 624 QFVGACLNDPSQFAIVTQYISGGSLFSLLHE-QKRILDLQSKLIIAVDVAKGMEYLHNLT 682 Query: 179 --FIHRDLKSDNLLISGDKSIKIADFGVARI--EVKTEGMTPETGTYRWMAPEMI-QHRP 343 IHRDL S N+L+ D +ADFG +R + + MT + G RWMAPE+ Q Sbjct: 683 QPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNLRWMAPEVFTQCTR 742 Query: 344 YNQKVDVYSFGIVLWELITGTLPF 415 Y K DV+S+ + LWE++TG +PF Sbjct: 743 YTIKADVFSYALCLWEILTGEIPF 766
>LIMK1_RAT (P53669) LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1)| Length = 647 Score = 105 bits (262), Expect = 5e-23 Identities = 57/147 (38%), Positives = 83/147 (56%), Gaps = 15/147 (10%) Frame = +2 Query: 2 KFVGACRKPIVWCIVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGF 181 KF+G K +T Y KGG++R + + + P V A D+A GMAY+H + Sbjct: 398 KFIGVLYKDKRLNFITEYIKGGTLRGII-KSMDSQYPWSQRVSFAKDIASGMAYLHSMNI 456 Query: 182 IHRDLKSDNLLISGDKSIKIADFGVARIEVKTEGMTPE---------------TGTYRWM 316 IHRDL S N L+ ++++ +ADFG+AR+ + +G + + G WM Sbjct: 457 IHRDLNSHNCLVRENRNVVVADFGLARLMIDEKGQSEDLRSLKKPDRKKRYTVVGNPYWM 516 Query: 317 APEMIQHRPYNQKVDVYSFGIVLWELI 397 APEMI R Y++KVDV+SFGIVL E+I Sbjct: 517 APEMINGRSYDEKVDVFSFGIVLCEII 543
>LIMK1_CHICK (Q8QFP8) LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (chLIMK1)| Length = 662 Score = 103 bits (258), Expect = 1e-22 Identities = 61/148 (41%), Positives = 82/148 (55%), Gaps = 16/148 (10%) Frame = +2 Query: 2 KFVGACRKPIVWCIVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGF 181 KF+G K +T Y KGG++R + + + P V A D+A GMAY+H + Sbjct: 405 KFIGVLYKEKRLNFITEYIKGGTLRGLI-KSMDSHYPWSQRVSFAKDIAAGMAYLHSMNI 463 Query: 182 IHRDLKSDNLLISGDKSIKIADFGVARIEVKTEGMTPE----------------TGTYRW 313 IHRDL S N L+ +KS+ +ADFG+AR+ V E PE G W Sbjct: 464 IHRDLNSHNCLVRENKSVVVADFGLARLMV-DEKNQPEHLQNLKKPDRKKRYTVVGNPYW 522 Query: 314 MAPEMIQHRPYNQKVDVYSFGIVLWELI 397 MAPEMI R Y++KVD++SFGIVL E+I Sbjct: 523 MAPEMINGRSYDEKVDIFSFGIVLCEII 550
>CTR1_ARATH (Q05609) Serine/threonine-protein kinase CTR1 (EC 2.7.11.1)| Length = 821 Score = 103 bits (258), Expect = 1e-22 Identities = 57/141 (40%), Positives = 83/141 (58%), Gaps = 4/141 (2%) Frame = +2 Query: 5 FVGACRKPIVWCIVTGYAKGGSVRNFLNRRQNRS-VPLKLAVKQALDVARGMAYVHGLG- 178 F+GA +P IVT Y GS+ L++ R + + + A DVA+GM Y+H Sbjct: 611 FMGAVTQPPNLSIVTEYLSRGSLYRLLHKSGAREQLDERRRLSMAYDVAKGMNYLHNRNP 670 Query: 179 -FIHRDLKSDNLLISGDKSIKIADFGVARIEVKTE-GMTPETGTYRWMAPEMIQHRPYNQ 352 +HRDLKS NLL+ ++K+ DFG++R++ T GT WMAPE+++ P N+ Sbjct: 671 PIVHRDLKSPNLLVDKKYTVKVCDFGLSRLKASTFLSSKSAAGTPEWMAPEVLRDEPSNE 730 Query: 353 KVDVYSFGIVLWELITGTLPF 415 K DVYSFG++LWEL T P+ Sbjct: 731 KSDVYSFGVILWELATLQQPW 751
>LIMK1_HUMAN (P53667) LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1)| Length = 647 Score = 103 bits (258), Expect = 1e-22 Identities = 61/148 (41%), Positives = 82/148 (55%), Gaps = 16/148 (10%) Frame = +2 Query: 2 KFVGACRKPIVWCIVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGF 181 KF+G K +T Y KGG++R + + + P V A D+A GMAY+H + Sbjct: 398 KFIGVLYKDKRLNFITEYIKGGTLRGII-KSMDSQYPWSQRVSFAKDIASGMAYLHSMNI 456 Query: 182 IHRDLKSDNLLISGDKSIKIADFGVARIEVKTEGMTPE----------------TGTYRW 313 IHRDL S N L+ +K++ +ADFG+AR+ V E PE G W Sbjct: 457 IHRDLNSHNCLVRENKNVVVADFGLARLMV-DEKTQPEGLRSLKKPDRKKRYTVVGNPYW 515 Query: 314 MAPEMIQHRPYNQKVDVYSFGIVLWELI 397 MAPEMI R Y++KVDV+SFGIVL E+I Sbjct: 516 MAPEMINGRSYDEKVDVFSFGIVLCEII 543
>M3K11_HUMAN (Q16584) Mitogen-activated protein kinase kinase kinase 11 (EC| 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline-rich kinase) Length = 847 Score = 103 bits (257), Expect = 2e-22 Identities = 62/139 (44%), Positives = 87/139 (62%), Gaps = 11/139 (7%) Frame = +2 Query: 38 CIVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHG---LGFIHRDLKSDN 208 C+V YA GG + L R VP + V A+ +ARGM Y+H + IHRDLKS+N Sbjct: 190 CLVMEYAAGGPLSRAL---AGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNN 246 Query: 209 LLI-----SGD---KSIKIADFGVARIEVKTEGMTPETGTYRWMAPEMIQHRPYNQKVDV 364 +L+ S D K++KI DFG+AR KT M+ GTY WMAPE+I+ +++ DV Sbjct: 247 ILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSA-AGTYAWMAPEVIKASTFSKGSDV 305 Query: 365 YSFGIVLWELITGTLPFLG 421 +SFG++LWEL+TG +P+ G Sbjct: 306 WSFGVLLWELLTGEVPYRG 324
>TNI3K_MOUSE (Q5GIG6) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 833 Score = 103 bits (257), Expect = 2e-22 Identities = 62/144 (43%), Positives = 86/144 (59%), Gaps = 6/144 (4%) Frame = +2 Query: 2 KFVGACRK-PIVWCIVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLG 178 +FVGAC P + IVT Y GGS+ + L+ Q R + L+ + A+DVA+GM Y+H L Sbjct: 521 QFVGACLDDPSQFAIVTQYISGGSLFSLLHE-QKRILDLQSKLIIAVDVAKGMEYLHSLT 579 Query: 179 --FIHRDLKSDNLLISGDKSIKIADFGVARI--EVKTEGMTPETGTYRWMAPEMI-QHRP 343 IHRDL S N+L+ D +ADFG +R + + MT + G RWMAPE+ Q Sbjct: 580 QPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNLRWMAPEVFTQCTR 639 Query: 344 YNQKVDVYSFGIVLWELITGTLPF 415 Y K DV+S+ + LWEL+ G +PF Sbjct: 640 YTIKADVFSYALCLWELLIGEIPF 663
>LIMK1_MOUSE (P53668) LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (KIZ-1)| Length = 647 Score = 103 bits (257), Expect = 2e-22 Identities = 56/147 (38%), Positives = 82/147 (55%), Gaps = 15/147 (10%) Frame = +2 Query: 2 KFVGACRKPIVWCIVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGF 181 KF+G K +T Y KGG++R + + + P V A D+A GMAY+H + Sbjct: 398 KFIGVLYKDKRLNFITEYIKGGTLRGII-KNMDSQYPWSQRVSFAKDIASGMAYLHSMNI 456 Query: 182 IHRDLKSDNLLISGDKSIKIADFGVARIEVKTEGMTPE---------------TGTYRWM 316 IHRDL S N L+ ++++ +ADFG+AR+ + + + + G WM Sbjct: 457 IHRDLNSHNCLVRENRNVVVADFGLARLMIDEKNQSEDLRSLKKPDRKKRYTVVGNPYWM 516 Query: 317 APEMIQHRPYNQKVDVYSFGIVLWELI 397 APEMI R Y++KVDV+SFGIVL E+I Sbjct: 517 APEMINGRSYDEKVDVFSFGIVLCEII 543
>YR831_MIMIV (Q7T6Y2) Putative serine/threonine-protein kinase/receptor R831| precursor (EC 2.7.11.1) Length = 1624 Score = 102 bits (254), Expect = 4e-22 Identities = 59/141 (41%), Positives = 84/141 (59%), Gaps = 4/141 (2%) Frame = +2 Query: 5 FVGACRKPIVWCIVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQAL--DVARGMAYVHGLG 178 F+GAC K CIVT Y + G++R+ L +N + + A K L A G+ Y+H Sbjct: 1424 FIGACIKKPNICIVTEYMRMGNLRDVL---KNPDIKITFANKLKLLYGAAMGIDYLHSSN 1480 Query: 179 --FIHRDLKSDNLLISGDKSIKIADFGVARIEVKTEGMTPETGTYRWMAPEMIQHRPYNQ 352 +HRD+K N+L+ ++KIADFG ARI+ MT GT W APE+I+ Y + Sbjct: 1481 PMIVHRDIKPANILVDEHFNVKIADFGFARIKEDNTTMT-RCGTPCWTAPEVIRGEKYCE 1539 Query: 353 KVDVYSFGIVLWELITGTLPF 415 K DV+SFG+V+WE++TG PF Sbjct: 1540 KADVFSFGVVMWEVLTGKEPF 1560 Score = 95.9 bits (237), Expect = 4e-20 Identities = 50/144 (34%), Positives = 79/144 (54%), Gaps = 5/144 (3%) Frame = +2 Query: 5 FVGACRKPIVWCIVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFI 184 F+ A K CIV + GS+ + L +P L +K A ++GM ++H G + Sbjct: 846 FMAASTKSPNMCIVMEFMSLGSLYDLLGNELIPEIPYALKIKMAYQASKGMHFLHSSGIV 905 Query: 185 HRDLKSDNLLISGDKSIKIADFGVARIEVKTEGMTPE---TGTYRWMAPEMIQHRPYNQK 355 HRDLKS NLL+ ++K++DFG+ +++ + + GT W+APE++ Sbjct: 906 HRDLKSLNLLLDSKWNVKVSDFGLTKVKSELDKKKTNDNIIGTIHWIAPEILNDSTEVDY 965 Query: 356 V--DVYSFGIVLWELITGTLPFLG 421 + DVYSFGI+LWEL+T P+ G Sbjct: 966 ILADVYSFGIILWELLTREQPYKG 989
>M3KL4_HUMAN (Q5TCX8) Mitogen-activated protein kinase kinase kinase (EC| 2.7.11.25) (Mixed lineage kinase 4) Length = 1036 Score = 102 bits (253), Expect = 5e-22 Identities = 58/160 (36%), Positives = 92/160 (57%), Gaps = 23/160 (14%) Frame = +2 Query: 11 GACRKPIVWCIVTGYAKGGSVRNFL------------NRRQNRSVPLKLAVKQALDVARG 154 G C + C+V +A+GG++ L R+ R +P + V A+ +ARG Sbjct: 188 GVCLQQPHLCLVLEFARGGALNRALAAANAAPDPRAPGPRRARRIPPHVLVNWAVQIARG 247 Query: 155 MAYVHGLGFI---HRDLKSDNLLISG--------DKSIKIADFGVARIEVKTEGMTPETG 301 M Y+H F+ HRDLKS N+L+ +K++KI DFG+AR +T M+ G Sbjct: 248 MLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRTTKMST-AG 306 Query: 302 TYRWMAPEMIQHRPYNQKVDVYSFGIVLWELITGTLPFLG 421 TY WMAPE+I+ +++ D++S+G++LWEL+TG +P+ G Sbjct: 307 TYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLTGEVPYRG 346
>M3K7_MOUSE (Q62073) Mitogen-activated protein kinase kinase kinase 7 (EC| 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1) Length = 579 Score = 100 bits (249), Expect = 2e-21 Identities = 63/152 (41%), Positives = 91/152 (59%), Gaps = 11/152 (7%) Frame = +2 Query: 2 KFVGACRKPIVWCIVTGYAKGGSVRNFLNRRQNRSVPLKL-----AVKQALDVARGMAYV 166 K GAC P+ C+V YA+GGS+ N L+ + PL A+ L ++G+AY+ Sbjct: 91 KLYGACLNPV--CLVMEYAEGGSLYNVLHGAE----PLPYYTAAHAMSWCLQCSQGVAYL 144 Query: 167 HGL---GFIHRDLKSDNLL-ISGDKSIKIADFGVARIEVKTEGMTPETGTYRWMAPEMIQ 334 H + IHRDLK NLL ++G +KI DFG A +++T MT G+ WMAPE+ + Sbjct: 145 HSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTA-CDIQTH-MTNNKGSAAWMAPEVFE 202 Query: 335 HRPYNQKVDVYSFGIVLWELITGTLPF--LGG 424 Y++K DV+S+GI+LWE+IT PF +GG Sbjct: 203 GSNYSEKCDVFSWGIILWEVITRRKPFDEIGG 234
>M3K7_HUMAN (O43318) Mitogen-activated protein kinase kinase kinase 7 (EC| 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1) Length = 606 Score = 100 bits (249), Expect = 2e-21 Identities = 63/152 (41%), Positives = 91/152 (59%), Gaps = 11/152 (7%) Frame = +2 Query: 2 KFVGACRKPIVWCIVTGYAKGGSVRNFLNRRQNRSVPLKL-----AVKQALDVARGMAYV 166 K GAC P+ C+V YA+GGS+ N L+ + PL A+ L ++G+AY+ Sbjct: 91 KLYGACLNPV--CLVMEYAEGGSLYNVLHGAE----PLPYYTAAHAMSWCLQCSQGVAYL 144 Query: 167 HGL---GFIHRDLKSDNLL-ISGDKSIKIADFGVARIEVKTEGMTPETGTYRWMAPEMIQ 334 H + IHRDLK NLL ++G +KI DFG A +++T MT G+ WMAPE+ + Sbjct: 145 HSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTA-CDIQTH-MTNNKGSAAWMAPEVFE 202 Query: 335 HRPYNQKVDVYSFGIVLWELITGTLPF--LGG 424 Y++K DV+S+GI+LWE+IT PF +GG Sbjct: 203 GSNYSEKCDVFSWGIILWEVITRRKPFDEIGG 234
>BRAF1_MOUSE (P28028) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Fragment) Length = 328 Score = 98.6 bits (244), Expect = 6e-21 Identities = 57/143 (39%), Positives = 89/143 (62%), Gaps = 6/143 (4%) Frame = +2 Query: 5 FVGACRKPIVWCIVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFI 184 F+G KP + IVT + +G S+ + L+ + + +KL + A A+GM Y+H I Sbjct: 78 FMGYSTKPQL-AIVTQWCEGSSLYHHLHIIETKFEMIKL-IDIARQTAQGMDYLHAKSII 135 Query: 185 HRDLKSDNLLISGDKSIKIADFGVARIEVKTEG---MTPETGTYRWMAPEMIQ---HRPY 346 HRDLKS+N+ + D ++KI DFG+A ++ + G +G+ WMAPE+I+ PY Sbjct: 136 HRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPY 195 Query: 347 NQKVDVYSFGIVLWELITGTLPF 415 + + DVY+FGIVL+EL+TG LP+ Sbjct: 196 SFQSDVYAFGIVLYELMTGQLPY 218
>BRAF1_CHICK (Q04982) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Rmil serine/threonine-protein kinase) (c-Rmil) Length = 806 Score = 98.6 bits (244), Expect = 6e-21 Identities = 57/143 (39%), Positives = 89/143 (62%), Gaps = 6/143 (4%) Frame = +2 Query: 5 FVGACRKPIVWCIVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFI 184 F+G KP + IVT + +G S+ + L+ + + +KL + A A+GM Y+H I Sbjct: 556 FMGYSTKPQL-AIVTQWCEGSSLYHHLHIIETKFEMIKL-IDIARQTAQGMDYLHAKSII 613 Query: 185 HRDLKSDNLLISGDKSIKIADFGVARIEVKTEG---MTPETGTYRWMAPEMIQ---HRPY 346 HRDLKS+N+ + D ++KI DFG+A ++ + G +G+ WMAPE+I+ PY Sbjct: 614 HRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPY 673 Query: 347 NQKVDVYSFGIVLWELITGTLPF 415 + + DVY+FGIVL+EL+TG LP+ Sbjct: 674 SFQSDVYAFGIVLYELMTGQLPY 696
>BRAF1_COTJA (P34908) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (RMIL serine/threonine-protein kinase) (c-RMIL) Length = 807 Score = 98.6 bits (244), Expect = 6e-21 Identities = 57/143 (39%), Positives = 89/143 (62%), Gaps = 6/143 (4%) Frame = +2 Query: 5 FVGACRKPIVWCIVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFI 184 F+G KP + IVT + +G S+ + L+ + + +KL + A A+GM Y+H I Sbjct: 556 FMGYSTKPQL-AIVTQWCEGSSLYHHLHIIETKFEMIKL-IDIARQTAQGMDYLHAKSII 613 Query: 185 HRDLKSDNLLISGDKSIKIADFGVARIEVKTEG---MTPETGTYRWMAPEMIQ---HRPY 346 HRDLKS+N+ + D ++KI DFG+A ++ + G +G+ WMAPE+I+ PY Sbjct: 614 HRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPY 673 Query: 347 NQKVDVYSFGIVLWELITGTLPF 415 + + DVY+FGIVL+EL+TG LP+ Sbjct: 674 SFQSDVYAFGIVLYELMTGQLPY 696
>RMIL_AVII1 (P10533) Serine/threonine-protein kinase transforming protein Rmil| (EC 2.7.11.1) Length = 367 Score = 98.6 bits (244), Expect = 6e-21 Identities = 57/143 (39%), Positives = 89/143 (62%), Gaps = 6/143 (4%) Frame = +2 Query: 5 FVGACRKPIVWCIVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFI 184 F+G KP + IVT + +G S+ + L+ + + +KL + A A+GM Y+H I Sbjct: 126 FMGYSTKPQL-AIVTQWCEGSSLYHHLHIIETKFEMIKL-IDIARQTAQGMDYLHAKSII 183 Query: 185 HRDLKSDNLLISGDKSIKIADFGVARIEVKTEG---MTPETGTYRWMAPEMIQ---HRPY 346 HRDLKS+N+ + D ++KI DFG+A ++ + G +G+ WMAPE+I+ PY Sbjct: 184 HRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPY 243 Query: 347 NQKVDVYSFGIVLWELITGTLPF 415 + + DVY+FGIVL+EL+TG LP+ Sbjct: 244 SFQSDVYAFGIVLYELMTGQLPY 266
>BRAF1_HUMAN (P15056) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (p94) (v-Raf murine sarcoma viral oncogene homolog B1) Length = 766 Score = 98.6 bits (244), Expect = 6e-21 Identities = 57/143 (39%), Positives = 89/143 (62%), Gaps = 6/143 (4%) Frame = +2 Query: 5 FVGACRKPIVWCIVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFI 184 F+G KP + IVT + +G S+ + L+ + + +KL + A A+GM Y+H I Sbjct: 516 FMGYSTKPQL-AIVTQWCEGSSLYHHLHIIETKFEMIKL-IDIARQTAQGMDYLHAKSII 573 Query: 185 HRDLKSDNLLISGDKSIKIADFGVARIEVKTEG---MTPETGTYRWMAPEMIQ---HRPY 346 HRDLKS+N+ + D ++KI DFG+A ++ + G +G+ WMAPE+I+ PY Sbjct: 574 HRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPY 633 Query: 347 NQKVDVYSFGIVLWELITGTLPF 415 + + DVY+FGIVL+EL+TG LP+ Sbjct: 634 SFQSDVYAFGIVLYELMTGQLPY 656
>RMIL_AVEVR (P27966) Serine/threonine-protein kinase transforming protein Rmil| (EC 2.7.11.1) Length = 450 Score = 98.6 bits (244), Expect = 6e-21 Identities = 57/143 (39%), Positives = 89/143 (62%), Gaps = 6/143 (4%) Frame = +2 Query: 5 FVGACRKPIVWCIVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFI 184 F+G KP + IVT + +G S+ + L+ + + +KL + A A+GM Y+H I Sbjct: 142 FMGYSTKPQL-AIVTQWCEGSSLYHHLHIIETKFEMIKL-IDIARQTAQGMDYLHAKSII 199 Query: 185 HRDLKSDNLLISGDKSIKIADFGVARIEVKTEG---MTPETGTYRWMAPEMIQ---HRPY 346 HRDLKS+N+ + D ++KI DFG+A ++ + G +G+ WMAPE+I+ PY Sbjct: 200 HRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPY 259 Query: 347 NQKVDVYSFGIVLWELITGTLPF 415 + + DVY+FGIVL+EL+TG LP+ Sbjct: 260 SFQSDVYAFGIVLYELMTGQLPY 282
>LIMK2_HUMAN (P53671) LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2)| Length = 638 Score = 96.3 bits (238), Expect = 3e-20 Identities = 56/153 (36%), Positives = 83/153 (54%), Gaps = 21/153 (13%) Frame = +2 Query: 2 KFVGACRKPIVWCIVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGF 181 KF+G K ++T Y +GG++++FL R P + V+ A +A GMAY+H + Sbjct: 390 KFIGVLYKDKKLNLLTEYIEGGTLKDFL--RSMDPFPWQQKVRFAKGIASGMAYLHSMCI 447 Query: 182 IHRDLKSDNLLISGDKSIKIADFGVARIEVKTEGMTP---------------------ET 298 IHRDL S N LI DK++ +ADFG++R+ V+ P Sbjct: 448 IHRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVV 507 Query: 299 GTYRWMAPEMIQHRPYNQKVDVYSFGIVLWELI 397 G WMAPEM+ + Y++ VD++SFGIVL E+I Sbjct: 508 GNPYWMAPEMLNGKSYDETVDIFSFGIVLCEII 540
>LIMK2_RAT (P53670) LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2)| Length = 638 Score = 95.9 bits (237), Expect = 4e-20 Identities = 57/153 (37%), Positives = 83/153 (54%), Gaps = 21/153 (13%) Frame = +2 Query: 2 KFVGACRKPIVWCIVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGF 181 KF+G K ++T Y +GG++++FL R P + V+ A +A GMAY+H + Sbjct: 390 KFIGVLYKDKKLNLLTEYIEGGTLKDFL--RNVDPFPWQQKVRFAKGIASGMAYLHSMCI 447 Query: 182 IHRDLKSDNLLISGDKSIKIADFGVARIEVKTEGMTP---------------------ET 298 IHRDL S N LI DK++ +ADFG++R+ V+ P Sbjct: 448 IHRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRPPVEKAATKKRTLRKSDRKKRYTVV 507 Query: 299 GTYRWMAPEMIQHRPYNQKVDVYSFGIVLWELI 397 G WMAPEM+ + Y++ VDV+SFGIVL E+I Sbjct: 508 GNPYWMAPEMLNGKSYDETVDVFSFGIVLCEII 540
>MIL_AVIMH (P00531) Serine/threonine-protein kinase transforming protein mil| (EC 2.7.11.1) Length = 380 Score = 95.5 bits (236), Expect = 5e-20 Identities = 51/131 (38%), Positives = 83/131 (63%), Gaps = 6/131 (4%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLIS 220 IVT + +G S+ L+ ++ + +L + A A+GM Y+H IHRD+KS+N+ + Sbjct: 152 IVTQWCEGSSLYKHLHVQETKFQMFQL-IDIARQTAQGMDYLHAKNIIHRDMKSNNIFLH 210 Query: 221 GDKSIKIADFGVARIEVKTEG---MTPETGTYRWMAPEMIQ---HRPYNQKVDVYSFGIV 382 G ++KI DFG+A ++ + G + TG+ WMAPE+I+ P++ + DVYS+GIV Sbjct: 211 GGLTVKIGDFGLATVKSRWSGSQQVEQPTGSILWMAPEVIRMQDSNPFSFQSDVYSYGIV 270 Query: 383 LWELITGTLPF 415 L+EL+TG LP+ Sbjct: 271 LYELMTGELPY 281
>LIMK2_MOUSE (O54785) LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2)| Length = 638 Score = 95.1 bits (235), Expect = 6e-20 Identities = 58/153 (37%), Positives = 86/153 (56%), Gaps = 21/153 (13%) Frame = +2 Query: 2 KFVGACRKPIVWCIVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGF 181 KF+G K ++T Y +GG++++FL R P + V+ A ++ GMAY+H + Sbjct: 390 KFIGVLYKDKKLNLLTEYIEGGTLKDFL--RSVDPFPWQQKVRFAKGISSGMAYLHSMCI 447 Query: 182 IHRDLKSDNLLISGDKSIKIADFGVARIEVK------TEGMTPETGTYR----------- 310 IHRDL S N LI DK++ +ADFG++R+ V+ E T + T R Sbjct: 448 IHRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRPPVEKATTKKRTLRKSDRKKRYTVV 507 Query: 311 ----WMAPEMIQHRPYNQKVDVYSFGIVLWELI 397 WMAPEM+ + Y++ VDV+SFGIVL E+I Sbjct: 508 GNPYWMAPEMLNGKSYDETVDVFSFGIVLCEII 540
>FYN_XENLA (P13406) Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2)| (p59-Fyn) Length = 536 Score = 94.7 bits (234), Expect = 8e-20 Identities = 55/131 (41%), Positives = 78/131 (59%), Gaps = 4/131 (3%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLIS 220 IVT Y GS+ +FL + R++ L V A VARGMAY+ + +IHRDL+S N+L+ Sbjct: 339 IVTEYMSKGSLLDFLKDGEGRALKLPNLVDMAAQVARGMAYIERMNYIHRDLRSANILVG 398 Query: 221 GDKSIKIADFGVARIEVKTEGMTPETGT---YRWMAPEMIQHRPYNQKVDVYSFGIVLWE 391 KIADFG+AR+ ++ T G +W APE + + K DV+SFGI+L E Sbjct: 399 NGLICKIADFGLARL-IEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTE 457 Query: 392 LIT-GTLPFLG 421 L+T G +P+ G Sbjct: 458 LVTKGRVPYPG 468
>KRAF1_DROME (P11346) Raf homolog serine/threonine-protein kinase dRAF-1 (EC| 2.7.11.1) (Protein pole-hole) Length = 739 Score = 94.4 bits (233), Expect = 1e-19 Identities = 54/143 (37%), Positives = 84/143 (58%), Gaps = 6/143 (4%) Frame = +2 Query: 5 FVGACRKPIVWCIVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFI 184 F+G KP + IVT + +G S+ ++ + + L + VA+GM Y+H I Sbjct: 488 FMGCVSKPSL-AIVTQWCEGSSLYKHVHVSETK-FKLNTLIDIGRQVAQGMDYLHAKNII 545 Query: 185 HRDLKSDNLLISGDKSIKIADFGVARIEVKTEG---MTPETGTYRWMAPEMIQHR---PY 346 HRDLKS+N+ + D S+KI DFG+A + + G TG+ WMAPE+I+ + PY Sbjct: 546 HRDLKSNNIFLHEDLSVKIGDFGLATAKTRWSGEKQANQPTGSILWMAPEVIRMQELNPY 605 Query: 347 NQKVDVYSFGIVLWELITGTLPF 415 + + DVY+FGIV++EL+ LP+ Sbjct: 606 SFQSDVYAFGIVMYELLAECLPY 628
>M3LK7_DROME (P83104) Putative mitogen-activated protein kinase kinase kinase| 7-like (EC 2.7.11.25) Length = 393 Score = 94.4 bits (233), Expect = 1e-19 Identities = 52/124 (41%), Positives = 74/124 (59%), Gaps = 3/124 (2%) Frame = +2 Query: 53 YAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLG--FIHRDLKSDNLLISGD 226 Y + GS+ N+L ++ AV+ AL A+ +AY+H L +HRD+K N+L+ Sbjct: 85 YLEEGSLHNYLYGDDKWEYTVEQAVRWALQCAKALAYLHSLDRPIVHRDIKPQNMLLYNQ 144 Query: 227 -KSIKIADFGVARIEVKTEGMTPETGTYRWMAPEMIQHRPYNQKVDVYSFGIVLWELITG 403 + +KI DFG+A + T GT R+MAPE I+H Y K DVYSFGI+LWEL+T Sbjct: 145 HEDLKICDFGLATD--MSNNKTDMQGTLRYMAPEAIKHLKYTAKCDVYSFGIMLWELMTR 202 Query: 404 TLPF 415 LP+ Sbjct: 203 QLPY 206
>ARAF_PIG (O19004) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (A-Raf-1) Length = 606 Score = 94.0 bits (232), Expect = 1e-19 Identities = 52/143 (36%), Positives = 89/143 (62%), Gaps = 6/143 (4%) Frame = +2 Query: 5 FVGACRKPIVWCIVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFI 184 F+G +P + I+T + +G S+ + L+ R ++L + A A+GM Y+H I Sbjct: 369 FMGFMTRP-GFAIITQWCEGSSLYHHLHVADTRFDMVQL-IDVARQTAQGMDYLHAKNII 426 Query: 185 HRDLKSDNLLISGDKSIKIADFGVARIEVKTEGMTP---ETGTYRWMAPEMIQHR---PY 346 HRDLKS+N+ + ++KI DFG+A ++ + G P +G+ WMA E+I+ + PY Sbjct: 427 HRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPY 486 Query: 347 NQKVDVYSFGIVLWELITGTLPF 415 + + DVY++G+VL+EL+TG+LP+ Sbjct: 487 SFQSDVYAYGVVLYELMTGSLPY 509
>ARAF_HUMAN (P10398) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (A-raf-1) (Proto-oncogene Pks) Length = 606 Score = 94.0 bits (232), Expect = 1e-19 Identities = 52/143 (36%), Positives = 89/143 (62%), Gaps = 6/143 (4%) Frame = +2 Query: 5 FVGACRKPIVWCIVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFI 184 F+G +P + I+T + +G S+ + L+ R ++L + A A+GM Y+H I Sbjct: 369 FMGFMTRP-GFAIITQWCEGSSLYHHLHVADTRFDMVQL-IDVARQTAQGMDYLHAKNII 426 Query: 185 HRDLKSDNLLISGDKSIKIADFGVARIEVKTEGMTP---ETGTYRWMAPEMIQHR---PY 346 HRDLKS+N+ + ++KI DFG+A ++ + G P +G+ WMA E+I+ + PY Sbjct: 427 HRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPY 486 Query: 347 NQKVDVYSFGIVLWELITGTLPF 415 + + DVY++G+VL+EL+TG+LP+ Sbjct: 487 SFQSDVYAYGVVLYELMTGSLPY 509
>ARAF_RAT (P14056) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) Length = 604 Score = 94.0 bits (232), Expect = 1e-19 Identities = 52/143 (36%), Positives = 89/143 (62%), Gaps = 6/143 (4%) Frame = +2 Query: 5 FVGACRKPIVWCIVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFI 184 F+G +P + I+T + +G S+ + L+ R ++L + A A+GM Y+H I Sbjct: 367 FMGFMTRP-GFAIITQWCEGSSLYHHLHVADTRFDMVQL-IDVARQTAQGMDYLHAKNII 424 Query: 185 HRDLKSDNLLISGDKSIKIADFGVARIEVKTEGMTP---ETGTYRWMAPEMIQHR---PY 346 HRDLKS+N+ + ++KI DFG+A ++ + G P +G+ WMA E+I+ + PY Sbjct: 425 HRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPY 484 Query: 347 NQKVDVYSFGIVLWELITGTLPF 415 + + DVY++G+VL+EL+TG+LP+ Sbjct: 485 SFQSDVYAYGVVLYELMTGSLPY 507
>ARAF_MOUSE (P04627) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) Length = 604 Score = 94.0 bits (232), Expect = 1e-19 Identities = 52/143 (36%), Positives = 89/143 (62%), Gaps = 6/143 (4%) Frame = +2 Query: 5 FVGACRKPIVWCIVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFI 184 F+G +P + I+T + +G S+ + L+ R ++L + A A+GM Y+H I Sbjct: 367 FMGFMTRP-GFAIITQWCEGSSLYHHLHVADTRFDMVQL-IDVARQTAQGMDYLHAKNII 424 Query: 185 HRDLKSDNLLISGDKSIKIADFGVARIEVKTEGMTP---ETGTYRWMAPEMIQHR---PY 346 HRDLKS+N+ + ++KI DFG+A ++ + G P +G+ WMA E+I+ + PY Sbjct: 425 HRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPY 484 Query: 347 NQKVDVYSFGIVLWELITGTLPF 415 + + DVY++G+VL+EL+TG+LP+ Sbjct: 485 SFQSDVYAYGVVLYELMTGSLPY 507
>ABL1_CAEEL (P03949) Tyrosine-protein kinase abl-1 (EC 2.7.10.2)| Length = 1224 Score = 93.2 bits (230), Expect = 2e-19 Identities = 50/144 (34%), Positives = 80/144 (55%), Gaps = 4/144 (2%) Frame = +2 Query: 2 KFVGACRKPIVWCIVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGF 181 + +G C + I+T + G++ +L R +P + V+ A +A GM+Y+ F Sbjct: 369 RLLGVCTHEAPFYIITEFMCNGNLLEYLRRTDKSLLPPIILVQMASQIASGMSYLEARHF 428 Query: 182 IHRDLKSDNLLISGDKSIKIADFGVARIEVKTEGMTPETGT---YRWMAPEMIQHRPYNQ 352 IHRDL + N L+S +KIADFG+AR +K + T G +W APE + ++ Sbjct: 429 IHRDLAARNCLVSEHNIVKIADFGLARF-MKEDTYTAHAGAKFPIKWTAPEGLAFNTFSS 487 Query: 353 KVDVYSFGIVLWELIT-GTLPFLG 421 K DV++FG++LWE+ T G P+ G Sbjct: 488 KSDVWAFGVLLWEIATYGMAPYPG 511
>RAF1_XENLA (P09560) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (C-RAF) Length = 638 Score = 93.2 bits (230), Expect = 2e-19 Identities = 58/152 (38%), Positives = 88/152 (57%), Gaps = 21/152 (13%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVAR----GMAYVHGLGFIHRDLKSDN 208 IVT + +G S+ L+ + K + Q +D+AR GM Y+H IHRD+KS+N Sbjct: 410 IVTQWCEGSSLYYHLH-----VLDTKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNN 464 Query: 209 LLISGDKSIKIADFGVARIEVKTEG---MTPETGTYRWMAPEMIQ---HRPYNQKVDVYS 370 + + ++KI DFG+A ++ + G + TG+ WMAPE+I+ + P++ + DVYS Sbjct: 465 IFLHEGLTVKIGDFGLATVKTRWSGSQQVEQLTGSILWMAPEVIRMQDNNPFSFQSDVYS 524 Query: 371 FGIVLWELITGTLP-----------FLGGRGG 433 +GIVL+EL+TG LP FL GRGG Sbjct: 525 YGIVLYELMTGELPYSHIRDRDQIIFLVGRGG 556
>RAF1_RAT (P11345) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 93.2 bits (230), Expect = 2e-19 Identities = 50/131 (38%), Positives = 83/131 (63%), Gaps = 6/131 (4%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLIS 220 IVT + +G S+ L+ ++ + +L + A A+GM Y+H IHRD+KS+N+ + Sbjct: 419 IVTQWCEGSSLYKHLHVQETKFQMFQL-IDIARQTAQGMDYLHAKNIIHRDMKSNNIFLH 477 Query: 221 GDKSIKIADFGVARIEVKTEG---MTPETGTYRWMAPEMIQ---HRPYNQKVDVYSFGIV 382 ++KI DFG+A ++ + G + TG+ WMAPE+I+ + P++ + DVYS+GIV Sbjct: 478 EGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIV 537 Query: 383 LWELITGTLPF 415 L+EL+TG LP+ Sbjct: 538 LYELMTGELPY 548
>RAF1_HUMAN (P04049) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 93.2 bits (230), Expect = 2e-19 Identities = 50/131 (38%), Positives = 83/131 (63%), Gaps = 6/131 (4%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLIS 220 IVT + +G S+ L+ ++ + +L + A A+GM Y+H IHRD+KS+N+ + Sbjct: 419 IVTQWCEGSSLYKHLHVQETKFQMFQL-IDIARQTAQGMDYLHAKNIIHRDMKSNNIFLH 477 Query: 221 GDKSIKIADFGVARIEVKTEG---MTPETGTYRWMAPEMIQ---HRPYNQKVDVYSFGIV 382 ++KI DFG+A ++ + G + TG+ WMAPE+I+ + P++ + DVYS+GIV Sbjct: 478 EGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIV 537 Query: 383 LWELITGTLPF 415 L+EL+TG LP+ Sbjct: 538 LYELMTGELPY 548
>LIMK2_CHICK (P53666) LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2)| Length = 642 Score = 92.8 bits (229), Expect = 3e-19 Identities = 57/153 (37%), Positives = 85/153 (55%), Gaps = 21/153 (13%) Frame = +2 Query: 2 KFVGACRKPIVWCIVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGF 181 KF+G K ++T Y +GG++++FL R P + V A +A GMAY+H + Sbjct: 390 KFIGVLYKDKKLNLLTEYIEGGTLKDFL--RNADPFPWQQKVSFAKGIASGMAYLHSMCI 447 Query: 182 IHRDLKSDNLLISGDKSIKIADFGVARIEVK------TEGMTPETGTYR----------- 310 IHRDL S N LI DK++ +ADFG++R+ V+ E + + T R Sbjct: 448 IHRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKKPTLEKPSAKKRTLRKSDRKKRYTVV 507 Query: 311 ----WMAPEMIQHRPYNQKVDVYSFGIVLWELI 397 WMAPEM+ + Y++ VD++SFGIVL E+I Sbjct: 508 GNPYWMAPEMLNGQSYDETVDIFSFGIVLCEII 540
>FYN_XIPHE (P27446) Proto-oncogene tyrosine-protein kinase FYN (EC 2.7.10.2)| (P59-FYN) Length = 536 Score = 92.8 bits (229), Expect = 3e-19 Identities = 54/131 (41%), Positives = 78/131 (59%), Gaps = 4/131 (3%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLIS 220 IVT Y GS+ +FL + R++ L V A VA GMAY+ + +IHRDL+S N+L+ Sbjct: 339 IVTEYMSKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVG 398 Query: 221 GDKSIKIADFGVARIEVKTEGMTPETGT---YRWMAPEMIQHRPYNQKVDVYSFGIVLWE 391 + KIADFG+AR+ ++ T G +W APE + + K DV+SFGI+L E Sbjct: 399 DNLVCKIADFGLARL-IEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTE 457 Query: 392 LIT-GTLPFLG 421 L+T G +P+ G Sbjct: 458 LVTKGRVPYPG 468
>FYN_MOUSE (P39688) Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2)| (p59-Fyn) Length = 533 Score = 92.4 bits (228), Expect = 4e-19 Identities = 54/131 (41%), Positives = 77/131 (58%), Gaps = 4/131 (3%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLIS 220 IVT Y GS+ +FL + R++ L V A VA GMAY+ + +IHRDL+S N+L+ Sbjct: 336 IVTEYMSKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVG 395 Query: 221 GDKSIKIADFGVARIEVKTEGMTPETGT---YRWMAPEMIQHRPYNQKVDVYSFGIVLWE 391 KIADFG+AR+ ++ T G +W APE + + K DV+SFGI+L E Sbjct: 396 NGLICKIADFGLARL-IEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTE 454 Query: 392 LIT-GTLPFLG 421 L+T G +P+ G Sbjct: 455 LVTKGRVPYPG 465
>FYN_CHICK (Q05876) Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2)| (p59-Fyn) Length = 533 Score = 92.4 bits (228), Expect = 4e-19 Identities = 57/138 (41%), Positives = 80/138 (57%), Gaps = 4/138 (2%) Frame = +2 Query: 20 RKPIVWCIVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLK 199 R+PI IVT Y GS+ FL + R++ L V A VA GMAY+ + +IHRDL+ Sbjct: 331 RRPIY--IVTEYMSKGSLLIFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLR 388 Query: 200 SDNLLISGDKSIKIADFGVARIEVKTEGMTPETGT---YRWMAPEMIQHRPYNQKVDVYS 370 S N+L+ KIADFG+AR+ ++ T G +W APE + + K DV+S Sbjct: 389 SANILVGNGLICKIADFGLARL-IEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWS 447 Query: 371 FGIVLWELIT-GTLPFLG 421 FGI+L EL+T G +P+ G Sbjct: 448 FGILLTELVTKGRVPYPG 465
>FYN_HUMAN (P06241) Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2)| (p59-Fyn) (Protooncogene Syn) (SLK) Length = 536 Score = 92.4 bits (228), Expect = 4e-19 Identities = 54/131 (41%), Positives = 77/131 (58%), Gaps = 4/131 (3%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLIS 220 IVT Y GS+ +FL + R++ L V A VA GMAY+ + +IHRDL+S N+L+ Sbjct: 339 IVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVG 398 Query: 221 GDKSIKIADFGVARIEVKTEGMTPETGT---YRWMAPEMIQHRPYNQKVDVYSFGIVLWE 391 KIADFG+AR+ ++ T G +W APE + + K DV+SFGI+L E Sbjct: 399 NGLICKIADFGLARL-IEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTE 457 Query: 392 LIT-GTLPFLG 421 L+T G +P+ G Sbjct: 458 LVTKGRVPYPG 468
>RAF1_CHICK (P05625) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (RAF-1) (C-RAF) (MIL proto-oncogene serine/threonine-protein kinase) (C-MIL) Length = 647 Score = 92.4 bits (228), Expect = 4e-19 Identities = 50/131 (38%), Positives = 82/131 (62%), Gaps = 6/131 (4%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLIS 220 IVT + +G S+ L+ ++ + +L + A A+GM Y+H IHRD+KS+N+ + Sbjct: 419 IVTQWCEGSSLYKHLHVQETKFQMFQL-IDIARQTAQGMDYLHAKNIIHRDMKSNNIFLH 477 Query: 221 GDKSIKIADFGVARIEVKTEG---MTPETGTYRWMAPEMIQ---HRPYNQKVDVYSFGIV 382 ++KI DFG+A ++ + G + TG+ WMAPE+I+ P++ + DVYS+GIV Sbjct: 478 EGLTVKIGDFGLATVKSRWSGSQQVEQPTGSILWMAPEVIRMQDSNPFSFQSDVYSYGIV 537 Query: 383 LWELITGTLPF 415 L+EL+TG LP+ Sbjct: 538 LYELMTGELPY 548
>LIMK1_XENLA (O42565) LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (xLIMK1)| Length = 615 Score = 92.4 bits (228), Expect = 4e-19 Identities = 53/140 (37%), Positives = 77/140 (55%), Gaps = 8/140 (5%) Frame = +2 Query: 2 KFVGACRKPIVWCIVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGF 181 KF+G K +T Y GG++R + + + P V A D+A GM Y+H + Sbjct: 373 KFIGVLYKDKRLNFITEYIPGGTLRRVI-KSMDTHCPWNQRVSFARDIAAGMTYLHSMNI 431 Query: 182 IHRDLKSDNLLISGDKSIKIADFGVAR-IEVKTEGMTPE-------TGTYRWMAPEMIQH 337 IHRDL S N L+ D + +A+FG++R I +T + + G WMAPEMI Sbjct: 432 IHRDLNSHNCLVREDGGLVVANFGLSRLIPEETRDLRKDRRKRYTVVGNPYWMAPEMING 491 Query: 338 RPYNQKVDVYSFGIVLWELI 397 R Y++ VDV+SFGIV+ E+I Sbjct: 492 RSYDESVDVFSFGIVICEII 511
>STK_HYDAT (P17713) Tyrosine-protein kinase STK (EC 2.7.10.2) (P57-STK)| Length = 509 Score = 91.3 bits (225), Expect = 9e-19 Identities = 51/138 (36%), Positives = 84/138 (60%), Gaps = 4/138 (2%) Frame = +2 Query: 20 RKPIVWCIVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLK 199 R+PI IVT Y GGS+ ++L++ + ++ L + A VA GMA++ G+IHRDL Sbjct: 305 REPIY--IVTEYMSGGSLLDYLSKGEGVNLQLPTLIDMAAQVASGMAFLEAQGYIHRDLA 362 Query: 200 SDNLLISGDKSIKIADFGVARIEVKTEGMTPETGT---YRWMAPEMIQHRPYNQKVDVYS 370 + N+L+ + K+ADFG+AR+ ++ + T G +W APE + + K DV+S Sbjct: 363 ARNILVGENYICKVADFGLARL-IEDDEYTAHEGAKFPIKWTAPEAALYNRFTIKSDVWS 421 Query: 371 FGIVLWELIT-GTLPFLG 421 FGI++ E++T G +P+ G Sbjct: 422 FGILMAEIVTKGRIPYPG 439
>FLK_RAT (P09760) Tyrosine-protein kinase FLK (EC 2.7.10.2) (Fragment)| Length = 323 Score = 91.3 bits (225), Expect = 9e-19 Identities = 55/147 (37%), Positives = 86/147 (58%), Gaps = 7/147 (4%) Frame = +2 Query: 2 KFVGAC--RKPIVWCIVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGL 175 K +G C R+P+ I+ GG +FL +R++ + LK V+ +LDVA GM Y+ G Sbjct: 123 KLIGVCTQRQPVY--IIMELVPGGDFLSFLRKRKDE-LKLKQLVRFSLDVAAGMLYLEGK 179 Query: 176 GFIHRDLKSDNLLISGDKSIKIADFGVARIEVKTEGMTPETG----TYRWMAPEMIQHRP 343 IHRDL + N L+ + ++KI+DFG++R E G+ +G +W APE + + Sbjct: 180 NCIHRDLAARNCLVGENNTLKISDFGMSRQE--DGGVYSSSGLKQIPIKWTAPEALNYGR 237 Query: 344 YNQKVDVYSFGIVLWELIT-GTLPFLG 421 Y+ + DV+SFGI+LWE + G P+ G Sbjct: 238 YSSESDVWSFGILLWETFSLGVCPYPG 264
>M3K7_DROME (Q9V3Q6) Mitogen-activated protein kinase kinase kinase 7 (EC| 2.7.11.25) (TGF-beta-activated kinase 1) (dTAK1) Length = 678 Score = 91.3 bits (225), Expect = 9e-19 Identities = 49/131 (37%), Positives = 79/131 (60%), Gaps = 4/131 (3%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLG---FIHRDLKSDNL 211 ++ +A+GGS+ NFL+ + + L A+ A A G+AY+H + IHRD+K NL Sbjct: 87 LIMEFAEGGSLHNFLHGKVKPAYSLAHAMSWARQCAEGLAYLHAMTPKPLIHRDVKPLNL 146 Query: 212 LISGD-KSIKIADFGVARIEVKTEGMTPETGTYRWMAPEMIQHRPYNQKVDVYSFGIVLW 388 L++ +++KI DFG + K+ MT G+ WMAPE+ + Y +K D++S+ IVLW Sbjct: 147 LLTNKGRNLKICDFGT--VADKSTMMTNNRGSAAWMAPEVFEGSKYTEKCDIFSWAIVLW 204 Query: 389 ELITGTLPFLG 421 E+++ PF G Sbjct: 205 EVLSRKQPFKG 215
>LCK_HUMAN (P06239) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell-specific protein-tyrosine kinase) Length = 508 Score = 90.9 bits (224), Expect = 1e-18 Identities = 49/130 (37%), Positives = 76/130 (58%), Gaps = 3/130 (2%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLIS 220 I+T Y + GS+ +FL + + + A +A GMA++ +IHRDL++ N+L+S Sbjct: 313 IITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVS 372 Query: 221 GDKSIKIADFGVARIEVKTEGMTPETGTY--RWMAPEMIQHRPYNQKVDVYSFGIVLWEL 394 S KIADFG+AR+ E E + +W APE I + + K DV+SFGI+L E+ Sbjct: 373 DTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEI 432 Query: 395 IT-GTLPFLG 421 +T G +P+ G Sbjct: 433 VTHGRIPYPG 442
>LCK_AOTNA (Q5PXS1) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) Length = 508 Score = 90.9 bits (224), Expect = 1e-18 Identities = 49/130 (37%), Positives = 76/130 (58%), Gaps = 3/130 (2%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLIS 220 I+T Y + GS+ +FL + + + A +A GMA++ +IHRDL++ N+L+S Sbjct: 313 IITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVS 372 Query: 221 GDKSIKIADFGVARIEVKTEGMTPETGTY--RWMAPEMIQHRPYNQKVDVYSFGIVLWEL 394 S KIADFG+AR+ E E + +W APE I + + K DV+SFGI+L E+ Sbjct: 373 DTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEI 432 Query: 395 IT-GTLPFLG 421 +T G +P+ G Sbjct: 433 VTHGRIPYPG 442
>BTKL_DROME (P08630) Tyrosine-protein kinase Btk29A (EC 2.7.10.2) (Dsrc28C)| Length = 786 Score = 90.9 bits (224), Expect = 1e-18 Identities = 48/140 (34%), Positives = 81/140 (57%), Gaps = 5/140 (3%) Frame = +2 Query: 11 GACRKPIVWCIVTGYAKGGSVRNFLNRRQNRSVP-LKLAVKQALDVARGMAYVHGLGFIH 187 G C K IVT Y K GS+ N+L R + + + L + + V++GM Y+ +IH Sbjct: 586 GVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGLLLDMCIQVSKGMTYLERHNYIH 645 Query: 188 RDLKSDNLLISGDKSIKIADFGVARIEVKTEGMTPETGT---YRWMAPEMIQHRPYNQKV 358 RDL + N L+ + +K+ADFG+AR V + T GT +W PE++ + ++ K Sbjct: 646 RDLAARNCLVGSENVVKVADFGLARY-VLDDQYTSSGGTKFPIKWAPPEVLNYTRFSSKS 704 Query: 359 DVYSFGIVLWELIT-GTLPF 415 DV+++G+++WE+ T G +P+ Sbjct: 705 DVWAYGVLMWEIFTCGKMPY 724
>RAF_MSV36 (P00532) Serine/threonine-protein kinase transforming protein raf| (EC 2.7.11.1) Length = 323 Score = 90.5 bits (223), Expect = 2e-18 Identities = 49/131 (37%), Positives = 81/131 (61%), Gaps = 6/131 (4%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLIS 220 IVT + +G S+ L+ ++ + +L + A A+GM Y+H IHRD+KS+N+ + Sbjct: 94 IVTQWCEGSSLYKHLHVQETKFQMFQL-IDIARQTAQGMDYLHAKNIIHRDMKSNNIFLH 152 Query: 221 GDKSIKIADFGVARIEVKTEG---MTPETGTYRWMAPEMIQ---HRPYNQKVDVYSFGIV 382 ++KI DFG+A ++ + G + TG+ WMAPE+I+ P++ + DVYS+GIV Sbjct: 153 EGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDDNPFSFQSDVYSYGIV 212 Query: 383 LWELITGTLPF 415 L+EL+ G LP+ Sbjct: 213 LYELMAGELPY 223
>FGR_MOUSE (P14234) Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2)| (P55-FGR) (C-FGR) Length = 517 Score = 90.5 bits (223), Expect = 2e-18 Identities = 54/131 (41%), Positives = 79/131 (60%), Gaps = 4/131 (3%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLIS 220 IVT + GS+ +FL R+ +++ L V A VA GMAY+ + +IHRDL++ N+L+ Sbjct: 320 IVTEFMCYGSLLDFLKDREGQNLMLPHLVDMAAQVAEGMAYMERMNYIHRDLRAANILVG 379 Query: 221 GDKSIKIADFGVARIEVKTEGMTPETGT---YRWMAPEMIQHRPYNQKVDVYSFGIVLWE 391 KIADFG+AR+ ++ P+ GT +W APE + K DV+SFGI+L E Sbjct: 380 EYLICKIADFGLARL-IEDNEYNPQQGTKFPIKWTAPEAALFGRFTVKSDVWSFGILLTE 438 Query: 392 LIT-GTLPFLG 421 LIT G +P+ G Sbjct: 439 LITKGRVPYPG 449
>RAF1_MOUSE (Q99N57) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 90.5 bits (223), Expect = 2e-18 Identities = 49/131 (37%), Positives = 81/131 (61%), Gaps = 6/131 (4%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLIS 220 IVT + +G S+ L+ ++ + +L + A A+GM Y+H IHRD+KS+N+ + Sbjct: 419 IVTQWCEGSSLYKHLHVQETKFQMFQL-IDIARQTAQGMDYLHAKNIIHRDMKSNNIFLH 477 Query: 221 GDKSIKIADFGVARIEVKTEG---MTPETGTYRWMAPEMIQ---HRPYNQKVDVYSFGIV 382 ++KI DFG+A ++ + G + TG+ WMAPE+I+ P++ + DVYS+GIV Sbjct: 478 EGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDDNPFSFQSDVYSYGIV 537 Query: 383 LWELITGTLPF 415 L+EL+ G LP+ Sbjct: 538 LYELMAGELPY 548
>LCK_MOUSE (P06240) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) Length = 508 Score = 90.1 bits (222), Expect = 2e-18 Identities = 49/130 (37%), Positives = 76/130 (58%), Gaps = 3/130 (2%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLIS 220 I+T Y + GS+ +FL + + + A +A GMA++ +IHRDL++ N+L+S Sbjct: 313 IITEYMENGSLVDFLKTPSGIKLNVNKLLDMAAQIAEGMAFIEEQNYIHRDLRAANILVS 372 Query: 221 GDKSIKIADFGVARIEVKTEGMTPETGTY--RWMAPEMIQHRPYNQKVDVYSFGIVLWEL 394 S KIADFG+AR+ E E + +W APE I + + K DV+SFGI+L E+ Sbjct: 373 DTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEI 432 Query: 395 IT-GTLPFLG 421 +T G +P+ G Sbjct: 433 VTHGRIPYPG 442
>PKN5_MYXXA (P54737) Serine/threonine-protein kinase pkn5 (EC 2.7.11.1)| Length = 380 Score = 89.7 bits (221), Expect = 3e-18 Identities = 38/96 (39%), Positives = 61/96 (63%), Gaps = 3/96 (3%) Frame = +2 Query: 137 LDVARGMAYVHGLGFIHRDLKSDNLLISGDKSIKIADFGVARIEVKTEGMTPE---TGTY 307 L + +AY+HG G +HRDLK N+++ D+ +++ DFG+A+ +T GTY Sbjct: 226 LQICEALAYIHGHGLVHRDLKPSNIMVDDDRQVRLMDFGLAKFLADDAAITEAGKLVGTY 285 Query: 308 RWMAPEMIQHRPYNQKVDVYSFGIVLWELITGTLPF 415 R+MAPE I P + + D+YS G++L+EL++G PF Sbjct: 286 RYMAPEQILGEPLDGRADLYSLGVILYELLSGRPPF 321
>TMK1_ARATH (P43298) Putative receptor protein kinase TMK1 precursor (EC| 2.7.11.1) Length = 942 Score = 89.4 bits (220), Expect = 4e-18 Identities = 48/95 (50%), Positives = 62/95 (65%), Gaps = 5/95 (5%) Frame = +2 Query: 134 ALDVARGMAYVHGLG---FIHRDLKSDNLLISGDKSIKIADFGVARIEVKTEGM--TPET 298 ALDVARG+ Y+HGL FIHRDLK N+L+ D K+ADFG+ R+ + +G T Sbjct: 695 ALDVARGVEYLHGLAHQSFIHRDLKPSNILLGDDMRAKVADFGLVRLAPEGKGSIETRIA 754 Query: 299 GTYRWMAPEMIQHRPYNQKVDVYSFGIVLWELITG 403 GT+ ++APE KVDVYSFG++L ELITG Sbjct: 755 GTFGYLAPEYAVTGRVTTKVDVYSFGVILMELITG 789
>TESK2_HUMAN (Q96S53) Dual specificity testis-specific protein kinase 2 (EC| 2.7.12.1) (Testicular protein kinase 2) Length = 571 Score = 89.4 bits (220), Expect = 4e-18 Identities = 53/139 (38%), Positives = 79/139 (56%), Gaps = 7/139 (5%) Frame = +2 Query: 2 KFVGACRKPIVWCIVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGF 181 +F+G C +T Y G++ L+ N +P + VK A D+A G++Y+H G Sbjct: 115 RFMGVCVHQGQLHALTEYINSGNLEQLLD--SNLHLPWTVRVKLAYDIAVGLSYLHFKGI 172 Query: 182 IHRDLKSDNLLISGDK---SIKIADFGVARIEVKTEGMTPE----TGTYRWMAPEMIQHR 340 HRDL S N LI D+ S +ADFG+A ++ M E G+ WMAPE+++ Sbjct: 173 FHRDLTSKNCLIKRDENGYSAVVADFGLAE-KIPDVSMGSEKLAVVGSPFWMAPEVLRDE 231 Query: 341 PYNQKVDVYSFGIVLWELI 397 PYN+K DV+S+GI+L E+I Sbjct: 232 PYNEKADVFSYGIILCEII 250
>LCK_CHICK (P42683) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (Protein-tyrosine kinase C-TKL) (p56tk1) Length = 507 Score = 89.4 bits (220), Expect = 4e-18 Identities = 48/130 (36%), Positives = 76/130 (58%), Gaps = 3/130 (2%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLIS 220 I+T Y + GS+ +FL + + + + A +A GMA++ +IHRDL++ N+L+S Sbjct: 312 IITEYMEKGSLVDFLKTSEGIKLSINKLLDMAAQIAEGMAFIEAKNYIHRDLRAANILVS 371 Query: 221 GDKSIKIADFGVARIEVKTEGMTPETGTY--RWMAPEMIQHRPYNQKVDVYSFGIVLWEL 394 KIADFG+AR+ E E + +W APE I + + K DV+SFGI+L E+ Sbjct: 372 EALCCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEI 431 Query: 395 IT-GTLPFLG 421 +T G +P+ G Sbjct: 432 VTYGRIPYPG 441
>LYN_HUMAN (P07948) Tyrosine-protein kinase Lyn (EC 2.7.10.2)| Length = 511 Score = 89.4 bits (220), Expect = 4e-18 Identities = 50/130 (38%), Positives = 75/130 (57%), Gaps = 3/130 (2%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLIS 220 I+T Y GS+ +FL + V L + + +A GMAY+ +IHRDL++ N+L+S Sbjct: 316 IITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVS 375 Query: 221 GDKSIKIADFGVARIEVKTEGMTPETGTY--RWMAPEMIQHRPYNQKVDVYSFGIVLWEL 394 KIADFG+AR+ E E + +W APE I + K DV+SFGI+L+E+ Sbjct: 376 ESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEI 435 Query: 395 IT-GTLPFLG 421 +T G +P+ G Sbjct: 436 VTYGKIPYPG 445
>BMX_MOUSE (P97504) Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2)| (Bone marrow tyrosine kinase gene in chromosome X protein homolog) Length = 651 Score = 89.0 bits (219), Expect = 5e-18 Identities = 50/142 (35%), Positives = 77/142 (54%), Gaps = 4/142 (2%) Frame = +2 Query: 2 KFVGACRKPIVWCIVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGF 181 KF G C K IVT Y G + N+L + + + ++ DV GMA++ F Sbjct: 450 KFYGVCSKKYPIYIVTEYITNGCLLNYL-KSHGKGLESCQLLEMCYDVCEGMAFLESHQF 508 Query: 182 IHRDLKSDNLLISGDKSIKIADFGVARIEVKTEGMTPETGT---YRWMAPEMIQHRPYNQ 352 IHRDL + N L+ D S+K++DFG+ R V + GT +W APE+ + Y+ Sbjct: 509 IHRDLAARNCLVDSDLSVKVSDFGMTRY-VLDDQYVSSVGTKFPVKWSAPEVFHYFKYSS 567 Query: 353 KVDVYSFGIVLWELIT-GTLPF 415 K DV++FGI++WE+ + G P+ Sbjct: 568 KSDVWAFGILMWEVFSLGKQPY 589
>HCK_RAT (P50545) Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK)| (Hemopoietic cell kinase) Length = 502 Score = 89.0 bits (219), Expect = 5e-18 Identities = 49/130 (37%), Positives = 74/130 (56%), Gaps = 3/130 (2%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLIS 220 IVT + GS+ +FL + PL + + ++ GMA++ +IHRDL++ N+L+S Sbjct: 307 IVTEFMAKGSLLDFLKSEEGSKQPLPKLIDFSAQISEGMAFIEQRNYIHRDLRAANILVS 366 Query: 221 GDKSIKIADFGVARIEVKTEGMTPETGTY--RWMAPEMIQHRPYNQKVDVYSFGIVLWEL 394 KIADFG+ARI E E + +W APE I + K DV+SFGI+L E+ Sbjct: 367 ASLVCKIADFGLARIIEDNEYTAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEI 426 Query: 395 IT-GTLPFLG 421 +T G +P+ G Sbjct: 427 VTYGRIPYPG 436
>BMX_HUMAN (P51813) Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2)| (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38) Length = 675 Score = 89.0 bits (219), Expect = 5e-18 Identities = 51/142 (35%), Positives = 76/142 (53%), Gaps = 4/142 (2%) Frame = +2 Query: 2 KFVGACRKPIVWCIVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGF 181 KF G C K IVT Y G + N+L P +L ++ DV GMA++ F Sbjct: 474 KFYGVCSKEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQL-LEMCYDVCEGMAFLESHQF 532 Query: 182 IHRDLKSDNLLISGDKSIKIADFGVARIEVKTEGMTPETGT---YRWMAPEMIQHRPYNQ 352 IHRDL + N L+ D +K++DFG+ R V + GT +W APE+ + Y+ Sbjct: 533 IHRDLAARNCLVDRDLCVKVSDFGMTRY-VLDDQYVSSVGTKFPVKWSAPEVFHYFKYSS 591 Query: 353 KVDVYSFGIVLWELIT-GTLPF 415 K DV++FGI++WE+ + G P+ Sbjct: 592 KSDVWAFGILMWEVFSLGKQPY 613
>HCK_MOUSE (P08103) Tyrosine-protein kinase HCK (EC 2.7.10.2)| (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK) Length = 523 Score = 89.0 bits (219), Expect = 5e-18 Identities = 49/130 (37%), Positives = 74/130 (56%), Gaps = 3/130 (2%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLIS 220 IVT + GS+ +FL + PL + + ++ GMA++ +IHRDL++ N+L+S Sbjct: 328 IVTEFMAKGSLLDFLKSEEGSKQPLPKLIDFSAQISEGMAFIEQRNYIHRDLRAANILVS 387 Query: 221 GDKSIKIADFGVARIEVKTEGMTPETGTY--RWMAPEMIQHRPYNQKVDVYSFGIVLWEL 394 KIADFG+ARI E E + +W APE I + K DV+SFGI+L E+ Sbjct: 388 ASLVCKIADFGLARIIEDNEYTAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEI 447 Query: 395 IT-GTLPFLG 421 +T G +P+ G Sbjct: 448 VTYGRIPYPG 457
>ABL_DROME (P00522) Tyrosine-protein kinase Abl (EC 2.7.10.2) (Abelson| protein) (D-ash) Length = 1620 Score = 89.0 bits (219), Expect = 5e-18 Identities = 44/142 (30%), Positives = 81/142 (57%), Gaps = 4/142 (2%) Frame = +2 Query: 2 KFVGACRKPIVWCIVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGF 181 + +G C + + I+T + G++ +FL ++ + A +A GM+Y+ + Sbjct: 429 QLIGVCTREPPFYIITEFMSHGNLLDFLRSAGRETLDAVALLYMATQIASGMSYLESRNY 488 Query: 182 IHRDLKSDNLLISGDKSIKIADFGVARIEVKTEGMTPETGT---YRWMAPEMIQHRPYNQ 352 IHRDL + N L+ +K +K+ADFG+AR+ ++ + T G +W APE + + ++ Sbjct: 489 IHRDLAARNCLVGDNKLVKVADFGLARL-MRDDTYTAHAGAKFPIKWTAPEGLAYNKFST 547 Query: 353 KVDVYSFGIVLWELIT-GTLPF 415 K DV++FG++LWE+ T G P+ Sbjct: 548 KSDVWAFGVLLWEIATYGMSPY 569
>FGR_HUMAN (P09769) Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2)| (P55-FGR) (C-FGR) Length = 529 Score = 89.0 bits (219), Expect = 5e-18 Identities = 53/131 (40%), Positives = 78/131 (59%), Gaps = 4/131 (3%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLIS 220 IVT + GS+ +FL + + + L V A VA GMAY+ + +IHRDL++ N+L+ Sbjct: 332 IVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERMNYIHRDLRAANILVG 391 Query: 221 GDKSIKIADFGVARIEVKTEGMTPETGT---YRWMAPEMIQHRPYNQKVDVYSFGIVLWE 391 + KIADFG+AR+ +K + P G+ +W APE + K DV+SFGI+L E Sbjct: 392 ERLACKIADFGLARL-IKDDEYNPCQGSKFPIKWTAPEAALFGRFTIKSDVWSFGILLTE 450 Query: 392 LIT-GTLPFLG 421 LIT G +P+ G Sbjct: 451 LITKGRIPYPG 461
>EPHA1_HUMAN (P21709) Ephrin type-A receptor 1 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EPH) Length = 976 Score = 88.6 bits (218), Expect = 6e-18 Identities = 50/136 (36%), Positives = 81/136 (59%), Gaps = 4/136 (2%) Frame = +2 Query: 20 RKPIVWCIVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLK 199 RKPI+ I+T + + G++ FL R+++ VP +L V +A GM Y+ ++HRDL Sbjct: 695 RKPIM--IITEFMENGALDAFLREREDQLVPGQL-VAMLQGIASGMNYLSNHNYVHRDLA 751 Query: 200 SDNLLISGDKSIKIADFGVARIEVKTEGMTPETG---TYRWMAPEMIQHRPYNQKVDVYS 370 + N+L++ + K++DFG+ R+ +G G RW APE I HR + DV+S Sbjct: 752 ARNILVNQNLCCKVSDFGLTRLLDDFDGTYETQGGKIPIRWTAPEAIAHRIFTTASDVWS 811 Query: 371 FGIVLWELIT-GTLPF 415 FGIV+WE+++ G P+ Sbjct: 812 FGIVMWEVLSFGDKPY 827
>TESK1_HUMAN (Q15569) Dual specificity testis-specific protein kinase 1 (EC| 2.7.12.1) (Testicular protein kinase 1) Length = 626 Score = 88.6 bits (218), Expect = 6e-18 Identities = 54/140 (38%), Positives = 81/140 (57%), Gaps = 8/140 (5%) Frame = +2 Query: 2 KFVGACRKPIVWCIVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGF 181 +F+G C +T Y GG++ L+ + S P++L + ALD+ARG+ Y+H G Sbjct: 114 RFMGVCVHQGQLHALTEYMNGGTLEQLLSSPEPLSWPVRLHL--ALDIARGLRYLHSKGV 171 Query: 182 IHRDLKSDNLLISGDK---SIKIADFGVA-RIEVKTEGMTPE----TGTYRWMAPEMIQH 337 HRDL S N L+ + + + DFG+A +I V EG E G+ WMAPE+++ Sbjct: 172 FHRDLTSKNCLVRREDRGFTAVVGDFGLAEKIPVYREGARKEPLAVVGSPYWMAPEVLRG 231 Query: 338 RPYNQKVDVYSFGIVLWELI 397 Y++K DV++FGIVL ELI Sbjct: 232 ELYDEKADVFAFGIVLCELI 251
>TESK1_RAT (Q63572) Dual specificity testis-specific protein kinase 1 (EC| 2.7.12.1) (Testicular protein kinase 1) Length = 628 Score = 88.6 bits (218), Expect = 6e-18 Identities = 54/140 (38%), Positives = 81/140 (57%), Gaps = 8/140 (5%) Frame = +2 Query: 2 KFVGACRKPIVWCIVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGF 181 +F+G C +T Y GG++ L+ + S P++L + ALD+A+G+ Y+H G Sbjct: 109 RFMGVCVHQGQLHALTEYMNGGTLEQLLSSPEPLSWPVRLHL--ALDIAQGLRYLHAKGV 166 Query: 182 IHRDLKSDNLLI---SGDKSIKIADFGVA-RIEVKTEGMTPE----TGTYRWMAPEMIQH 337 HRDL S N L+ G + + DFG+A +I V EG E G+ WMAPE+++ Sbjct: 167 FHRDLTSKNCLVRREDGGFTAVVGDFGLAEKIPVYREGARKEPLAVVGSPYWMAPEVLRG 226 Query: 338 RPYNQKVDVYSFGIVLWELI 397 Y++K DV++FGIVL ELI Sbjct: 227 ELYDEKADVFAFGIVLCELI 246
>HCK_HUMAN (P08631) Tyrosine-protein kinase HCK (EC 2.7.10.2)| (p59-HCK/p60-HCK) (Hemopoietic cell kinase) Length = 525 Score = 88.6 bits (218), Expect = 6e-18 Identities = 48/130 (36%), Positives = 74/130 (56%), Gaps = 3/130 (2%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLIS 220 I+T + GS+ +FL + PL + + +A GMA++ +IHRDL++ N+L+S Sbjct: 330 IITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVS 389 Query: 221 GDKSIKIADFGVARIEVKTEGMTPETGTY--RWMAPEMIQHRPYNQKVDVYSFGIVLWEL 394 KIADFG+AR+ E E + +W APE I + K DV+SFGI+L E+ Sbjct: 390 ASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEI 449 Query: 395 IT-GTLPFLG 421 +T G +P+ G Sbjct: 450 VTYGRIPYPG 459
>EPHA1_MOUSE (Q60750) Ephrin type-A receptor 1 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ESK) Length = 977 Score = 88.2 bits (217), Expect = 8e-18 Identities = 50/136 (36%), Positives = 81/136 (59%), Gaps = 4/136 (2%) Frame = +2 Query: 20 RKPIVWCIVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLK 199 RKPI+ I+T + + G++ FL R+++ P +L V L +A GM + G ++HRDL Sbjct: 696 RKPIM--IITEFMENGALDAFLKEREDQLAPGQL-VAMLLGIASGMNCLSGHNYVHRDLA 752 Query: 200 SDNLLISGDKSIKIADFGVARIEVKTEGMTPETG---TYRWMAPEMIQHRPYNQKVDVYS 370 + N+L++ + K++DFG+ R+ +G G RW APE I HR + DV+S Sbjct: 753 ARNILVNQNLCCKVSDFGLTRLLDDFDGTYETQGGKIPIRWTAPEAIAHRIFTTASDVWS 812 Query: 371 FGIVLWELIT-GTLPF 415 FGIV+WE+++ G P+ Sbjct: 813 FGIVMWEVLSFGDKPY 828
>LYN_RAT (Q07014) Tyrosine-protein kinase Lyn (EC 2.7.10.2)| Length = 511 Score = 88.2 bits (217), Expect = 8e-18 Identities = 49/130 (37%), Positives = 75/130 (57%), Gaps = 3/130 (2%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLIS 220 I+T + GS+ +FL + V L + + +A GMAY+ +IHRDL++ N+L+S Sbjct: 316 IITEFMAKGSLLDFLKSDEGSKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVS 375 Query: 221 GDKSIKIADFGVARIEVKTEGMTPETGTY--RWMAPEMIQHRPYNQKVDVYSFGIVLWEL 394 KIADFG+AR+ E E + +W APE I + K DV+SFGI+L+E+ Sbjct: 376 ESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEI 435 Query: 395 IT-GTLPFLG 421 +T G +P+ G Sbjct: 436 VTYGKIPYPG 445
>SPK1_DUGTI (P42687) Tyrosine-protein kinase SPK-1 (EC 2.7.10.2)| Length = 497 Score = 88.2 bits (217), Expect = 8e-18 Identities = 44/141 (31%), Positives = 79/141 (56%), Gaps = 8/141 (5%) Frame = +2 Query: 2 KFVGACRKP--IVWCIVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGL 175 + +G C +P + I+ Y K GS++ +L + L V +++ GMAY+ Sbjct: 277 ELLGVCTEPQDMPMLIIVEYMKNGSLKEYLKTPDGKKTNLNQMVHMMAEISEGMAYLESE 336 Query: 176 GFIHRDLKSDNLLISGDKSIKIADFGVARIEVKTEGMTPETG------TYRWMAPEMIQH 337 +HRDL++DN+L++ D + K+ADFG+ + T+G + Y+W APE + Sbjct: 337 KVVHRDLRADNILVANDLTRKVADFGLTEL---TDGSLGDQEKKTLRFPYKWTAPEAAKS 393 Query: 338 RPYNQKVDVYSFGIVLWELIT 400 + + K DV+S+GIV++E++T Sbjct: 394 KVFTSKSDVWSYGIVMFEILT 414
>CSK_RAT (P32577) Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase)| Length = 450 Score = 87.8 bits (216), Expect = 1e-17 Identities = 48/128 (37%), Positives = 75/128 (58%), Gaps = 3/128 (2%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLIS 220 IVT Y GS+ ++L R + +K +LDV M Y+ G F+HRDL + N+L+S Sbjct: 264 IVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVS 323 Query: 221 GDKSIKIADFGVARIEVKTEGMTPETG--TYRWMAPEMIQHRPYNQKVDVYSFGIVLWEL 394 D K++DFG+ K T +TG +W APE ++ + ++ K DV+SFGI+LWE+ Sbjct: 324 EDNVAKVSDFGL----TKEASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEI 379 Query: 395 IT-GTLPF 415 + G +P+ Sbjct: 380 YSFGRVPY 387
>CSK_HUMAN (P41240) Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase)| (Protein-tyrosine kinase CYL) Length = 450 Score = 87.8 bits (216), Expect = 1e-17 Identities = 48/128 (37%), Positives = 75/128 (58%), Gaps = 3/128 (2%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLIS 220 IVT Y GS+ ++L R + +K +LDV M Y+ G F+HRDL + N+L+S Sbjct: 264 IVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVS 323 Query: 221 GDKSIKIADFGVARIEVKTEGMTPETG--TYRWMAPEMIQHRPYNQKVDVYSFGIVLWEL 394 D K++DFG+ K T +TG +W APE ++ + ++ K DV+SFGI+LWE+ Sbjct: 324 EDNVAKVSDFGL----TKEASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEI 379 Query: 395 IT-GTLPF 415 + G +P+ Sbjct: 380 YSFGRVPY 387
>STE20_CANAL (Q92212) Serine/threonine-protein kinase STE20 homolog (EC 2.7.11.1)| Length = 1230 Score = 87.8 bits (216), Expect = 1e-17 Identities = 45/127 (35%), Positives = 74/127 (58%), Gaps = 1/127 (0%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLIS 220 ++ Y +GGS+ + + + + ++ L +G+ ++H G IHRD+KSDN+L++ Sbjct: 1026 VIMEYMEGGSLTDIVTHSVMTEGQIGVVCRETL---KGLKFLHSKGVIHRDIKSDNILLN 1082 Query: 221 GDKSIKIADFG-VARIEVKTEGMTPETGTYRWMAPEMIQHRPYNQKVDVYSFGIVLWELI 397 D +IKI DFG A+I GT WMAPE++ + Y KVDV+S GI++ E++ Sbjct: 1083 MDGNIKITDFGFCAQINEINSKRITMVGTPYWMAPEIVSRKEYGPKVDVWSLGIMIIEML 1142 Query: 398 TGTLPFL 418 G P+L Sbjct: 1143 EGEPPYL 1149
>LCK_SAISC (Q95KR7) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) Length = 508 Score = 87.8 bits (216), Expect = 1e-17 Identities = 47/130 (36%), Positives = 75/130 (57%), Gaps = 3/130 (2%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLIS 220 I+T Y + GS+ +FL + + + A + GMA++ +IHRDL++ N+L+S Sbjct: 313 IITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIVEGMAFLEERNYIHRDLRAANILVS 372 Query: 221 GDKSIKIADFGVARIEVKTEGMTPETGTY--RWMAPEMIQHRPYNQKVDVYSFGIVLWEL 394 S KIADFG+AR+ E E + +W APE I + + K DV+SFGI++ E+ Sbjct: 373 DTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILMTEI 432 Query: 395 IT-GTLPFLG 421 +T G +P+ G Sbjct: 433 VTHGRIPYPG 442
>SRC2_XENLA (P13116) Tyrosine-protein kinase Src-2 (EC 2.7.10.2) (p60-Src-2)| Length = 531 Score = 87.8 bits (216), Expect = 1e-17 Identities = 51/131 (38%), Positives = 75/131 (57%), Gaps = 4/131 (3%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLIS 220 IVT Y GS+ +FL R + L V A +A GMAYV + ++HRDL++ N+L+ Sbjct: 334 IVTEYMSKGSLLDFLKGEMGRYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVG 393 Query: 221 GDKSIKIADFGVARIEVKTEGMTPETGT---YRWMAPEMIQHRPYNQKVDVYSFGIVLWE 391 + K+ADFG+AR+ ++ T G +W APE + + K DV+SFGI+L E Sbjct: 394 ENLVCKVADFGLARL-IEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTE 452 Query: 392 LIT-GTLPFLG 421 L T G +P+ G Sbjct: 453 LTTKGRVPYPG 463
>SRC1_XENLA (P13115) Tyrosine-protein kinase Src-1 (EC 2.7.10.2) (p60-Src-1)| Length = 531 Score = 87.8 bits (216), Expect = 1e-17 Identities = 51/131 (38%), Positives = 75/131 (57%), Gaps = 4/131 (3%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLIS 220 IVT Y GS+ +FL R + L V A +A GMAYV + ++HRDL++ N+L+ Sbjct: 334 IVTEYISKGSLLDFLKGEMGRYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVG 393 Query: 221 GDKSIKIADFGVARIEVKTEGMTPETGT---YRWMAPEMIQHRPYNQKVDVYSFGIVLWE 391 + K+ADFG+AR+ ++ T G +W APE + + K DV+SFGI+L E Sbjct: 394 ENLVCKVADFGLARL-IEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTE 452 Query: 392 LIT-GTLPFLG 421 L T G +P+ G Sbjct: 453 LTTKGRVPYPG 463
>TESK2_RAT (Q924U5) Dual specificity testis-specific protein kinase 2 (EC| 2.7.12.1) (Testicular protein kinase 2) Length = 570 Score = 87.8 bits (216), Expect = 1e-17 Identities = 52/139 (37%), Positives = 79/139 (56%), Gaps = 7/139 (5%) Frame = +2 Query: 2 KFVGACRKPIVWCIVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGF 181 +F+G C +T Y G++ L+ N +P + VK A D+A G++Y+H G Sbjct: 115 RFMGVCVHQGQLHALTEYINSGNLEQLLD--SNLYLPWTVRVKLAYDIAVGLSYLHFKGI 172 Query: 182 IHRDLKSDNLLISGDK---SIKIADFGVARIEVKTEGMTPE----TGTYRWMAPEMIQHR 340 HRDL S N LI D+ S +ADFG+A ++ + E G+ WMAPE+++ Sbjct: 173 FHRDLTSKNCLIKRDENGYSAVVADFGLAE-KIPDASIGSEKLAVVGSPFWMAPEVLRDE 231 Query: 341 PYNQKVDVYSFGIVLWELI 397 PYN+K DV+S+GI+L E+I Sbjct: 232 PYNEKADVFSYGIILCEII 250
>YES_AVISY (P00527) Tyrosine-protein kinase transforming protein YES (EC| 2.7.10.2) (Fragment) Length = 528 Score = 87.8 bits (216), Expect = 1e-17 Identities = 50/131 (38%), Positives = 77/131 (58%), Gaps = 4/131 (3%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLIS 220 IVT + GS+ +FL + + + L V A +A GMAY+ + +IHRDL++ N+L+ Sbjct: 336 IVTEFMTKGSLLDFLKEGEGKFLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVG 395 Query: 221 GDKSIKIADFGVARIEVKTEGMTPETGT---YRWMAPEMIQHRPYNQKVDVYSFGIVLWE 391 + KIADFG+AR+ ++ T G +W APE + + K DV+SFGI+L E Sbjct: 396 DNLVCKIADFGLARL-IEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTE 454 Query: 392 LIT-GTLPFLG 421 L+T G +P+ G Sbjct: 455 LVTKGRVPYPG 465
>LYN_MOUSE (P25911) Tyrosine-protein kinase Lyn (EC 2.7.10.2)| Length = 511 Score = 87.8 bits (216), Expect = 1e-17 Identities = 49/130 (37%), Positives = 75/130 (57%), Gaps = 3/130 (2%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLIS 220 I+T + GS+ +FL + V L + + +A GMAY+ +IHRDL++ N+L+S Sbjct: 316 IITEFMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVS 375 Query: 221 GDKSIKIADFGVARIEVKTEGMTPETGTY--RWMAPEMIQHRPYNQKVDVYSFGIVLWEL 394 KIADFG+AR+ E E + +W APE I + K DV+SFGI+L+E+ Sbjct: 376 ESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEI 435 Query: 395 IT-GTLPFLG 421 +T G +P+ G Sbjct: 436 VTYGKIPYPG 445
>YES_CHICK (P09324) Tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes)| Length = 540 Score = 87.8 bits (216), Expect = 1e-17 Identities = 50/131 (38%), Positives = 77/131 (58%), Gaps = 4/131 (3%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLIS 220 IVT + GS+ +FL + + + L V A +A GMAY+ + +IHRDL++ N+L+ Sbjct: 343 IVTEFMTKGSLLDFLKEGEGKFLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVG 402 Query: 221 GDKSIKIADFGVARIEVKTEGMTPETGT---YRWMAPEMIQHRPYNQKVDVYSFGIVLWE 391 + KIADFG+AR+ ++ T G +W APE + + K DV+SFGI+L E Sbjct: 403 DNLVCKIADFGLARL-IEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTE 461 Query: 392 LIT-GTLPFLG 421 L+T G +P+ G Sbjct: 462 LVTKGRVPYPG 472
>KPC1_LYTPI (Q25378) Protein kinase C (EC 2.7.11.13)| Length = 658 Score = 87.4 bits (215), Expect = 1e-17 Identities = 45/102 (44%), Positives = 69/102 (67%), Gaps = 2/102 (1%) Frame = +2 Query: 122 AVKQALDVARGMAYVHGLGFIHRDLKSDNLLISGDKSIKIADFGVARIEVKTEGMTPET- 298 AV A ++A G+ Y+H G I+RDLK DN+L+ + IKIADFG+ + E EG T T Sbjct: 426 AVFYAAEIAVGLFYLHSQGVIYRDLKLDNVLVDAEGHIKIADFGMCK-EHMNEGDTTRTF 484 Query: 299 -GTYRWMAPEMIQHRPYNQKVDVYSFGIVLWELITGTLPFLG 421 GT ++APE++ ++PY + VD ++FG++L+E++ G PF G Sbjct: 485 CGTPDYIAPEIVAYQPYGKAVDWWAFGVLLYEMLAGQPPFDG 526
>PAKM_DROME (Q9VXE5) Serine/threonine-protein kinase PAK mbt (EC 2.7.11.1)| (p21-activated kinase-related protein) (Protein mushroom bodies tiny) Length = 639 Score = 87.4 bits (215), Expect = 1e-17 Identities = 43/126 (34%), Positives = 74/126 (58%), Gaps = 1/126 (0%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLIS 220 +V Y +GG++ + + + + KQ L + +AY+H G IHRD+KSD++L++ Sbjct: 440 VVMEYLEGGALTDIVTHSRMDEEQIATVCKQCL---KALAYLHSQGVIHRDIKSDSILLA 496 Query: 221 GDKSIKIADFG-VARIEVKTEGMTPETGTYRWMAPEMIQHRPYNQKVDVYSFGIVLWELI 397 D +K++DFG A++ + GT WM+PE+I PY +VD++S GI++ E++ Sbjct: 497 ADGRVKLSDFGFCAQVSQELPKRKSLVGTPYWMSPEVISRLPYGPEVDIWSLGIMVIEMV 556 Query: 398 TGTLPF 415 G PF Sbjct: 557 DGEPPF 562
>FER_HUMAN (P16591) Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2)| (p94-FER) (c-FER) Length = 822 Score = 87.4 bits (215), Expect = 1e-17 Identities = 54/147 (36%), Positives = 82/147 (55%), Gaps = 7/147 (4%) Frame = +2 Query: 2 KFVGAC--RKPIVWCIVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGL 175 K +G C R+P+ I+ GG FL R+++ + LK VK +LD A GM Y+ Sbjct: 622 KLIGVCTQRQPVY--IIMELVSGGDFLTFLRRKKDE-LKLKQLVKFSLDAAAGMLYLESK 678 Query: 176 GFIHRDLKSDNLLISGDKSIKIADFGVARIEVKTEGMTPETG----TYRWMAPEMIQHRP 343 IHRDL + N L+ + +KI+DFG++R E G+ +G +W APE + + Sbjct: 679 NCIHRDLAARNCLVGENNVLKISDFGMSRQE--DGGVYSSSGLKQIPIKWTAPEALNYGR 736 Query: 344 YNQKVDVYSFGIVLWELIT-GTLPFLG 421 Y+ + DV+SFGI+LWE + G P+ G Sbjct: 737 YSSESDVWSFGILLWETFSLGVCPYPG 763
>YRK_CHICK (Q02977) Proto-oncogene tyrosine-protein kinase Yrk (EC 2.7.10.2)| (p60-Yrk) (Yes-related kinase) Length = 535 Score = 87.4 bits (215), Expect = 1e-17 Identities = 51/131 (38%), Positives = 75/131 (57%), Gaps = 4/131 (3%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLIS 220 IVT + GS+ +FL R + L V A +A GMAY+ + +IHRDL++ N+L+ Sbjct: 338 IVTEFMSQGSLLDFLKDGDGRYLKLPQLVDMAAQIAAGMAYIERMNYIHRDLRAANILVG 397 Query: 221 GDKSIKIADFGVARIEVKTEGMTPETGT---YRWMAPEMIQHRPYNQKVDVYSFGIVLWE 391 + KIADFG+AR+ ++ T G +W APE + K DV+SFGI+L E Sbjct: 398 DNLVCKIADFGLARL-IEDNEYTARQGAKFPIKWTAPEAALFGKFTIKSDVWSFGILLTE 456 Query: 392 LIT-GTLPFLG 421 L+T G +P+ G Sbjct: 457 LVTKGRVPYPG 467
>CSK_MOUSE (P41241) Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase)| (Protein-tyrosine kinase MPK-2) (p50CSK) Length = 450 Score = 87.4 bits (215), Expect = 1e-17 Identities = 48/128 (37%), Positives = 75/128 (58%), Gaps = 3/128 (2%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLIS 220 IVT Y GS+ ++L R + +K +LDV M Y+ G F+HRDL + N+L+S Sbjct: 264 IVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVLEAMEYLEGNNFVHRDLAARNVLVS 323 Query: 221 GDKSIKIADFGVARIEVKTEGMTPETG--TYRWMAPEMIQHRPYNQKVDVYSFGIVLWEL 394 D K++DFG+ K T +TG +W APE ++ + ++ K DV+SFGI+LWE+ Sbjct: 324 EDNVAKVSDFGL----TKEASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEI 379 Query: 395 IT-GTLPF 415 + G +P+ Sbjct: 380 YSFGRVPY 387
>KYK1_DICDI (P18160) Non-receptor tyrosine kinase spore lysis A (EC 2.7.10.2)| (Tyrosine-protein kinase 1) Length = 1584 Score = 87.0 bits (214), Expect = 2e-17 Identities = 61/160 (38%), Positives = 87/160 (54%), Gaps = 23/160 (14%) Frame = +2 Query: 2 KFVGACRK--PIVWCIVTGYAKGGSVRNFLNRR-----QNRSVPLKLAVKQALDVARGMA 160 +F+GAC CIVT + GGS+R FL QN + LKLA LD+A+GM Sbjct: 1349 QFLGACTAGGEDHHCIVTEWMGGGSLRQFLTDHFNLLEQNPHIRLKLA----LDIAKGMN 1404 Query: 161 YVHGLG--FIHRDLKSDNLLISG-------------DKSIKIADFGVARIEVKTEG-MTP 292 Y+HG +HRDL S N+L+ D KI+DFG++R++ + MT Sbjct: 1405 YLHGWTPPILHRDLSSRNILLDHNIDPKNPVVSSRQDIKCKISDFGLSRLKKEQASQMTQ 1464 Query: 293 ETGTYRWMAPEMIQHRPYNQKVDVYSFGIVLWELITGTLP 412 G +MAPE+ + ++K DVYS+G+VL+EL+T P Sbjct: 1465 SVGCIPYMAPEVFKGDSNSEKSDVYSYGMVLFELLTSDEP 1504
>FGFR1_DROME (Q07407) Fibroblast growth factor receptor homolog 1 precursor (EC| 2.7.10.1) (Protein heartless) Length = 729 Score = 87.0 bits (214), Expect = 2e-17 Identities = 56/158 (35%), Positives = 85/158 (53%), Gaps = 22/158 (13%) Frame = +2 Query: 8 VGACRKPIVWCIVTGYAKGGSVRNFL------NRRQNRS------------VPLKLAVKQ 133 +G C + ++ YA G++++FL R Q+R + K +K Sbjct: 477 LGCCSQNGPLYVIVEYAPHGNLKDFLYKNRPFGRDQDRDSSQPPPSPPAHVITEKDLIKF 536 Query: 134 ALDVARGMAYVHGLGFIHRDLKSDNLLISGDKSIKIADFGVARIEVKTEGMTPETG---T 304 A +ARGM Y+ IHRDL + N+L+S D +KIADFG+AR T+ T Sbjct: 537 AHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRLP 596 Query: 305 YRWMAPEMIQHRPYNQKVDVYSFGIVLWELIT-GTLPF 415 +WMAPE +Q + Y+ K DV+S+GI+LWE++T G P+ Sbjct: 597 IKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPY 634
>HCK_MACFA (Q95M30) Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK)| (Hemopoietic cell kinase) Length = 503 Score = 87.0 bits (214), Expect = 2e-17 Identities = 49/130 (37%), Positives = 73/130 (56%), Gaps = 3/130 (2%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLIS 220 I+T + GS+ +FL + PL + + +A GMA++ +IHRDL++ N+L+S Sbjct: 308 IITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVS 367 Query: 221 GDKSIKIADFGVARIEVKTEGMTPETGTY--RWMAPEMIQHRPYNQKVDVYSFGIVLWEL 394 KIADFG+ARI E E + +W APE I K DV+SFGI+L E+ Sbjct: 368 ASLVCKIADFGLARIIEDNEYTAREGAKFPIKWTAPEAINFGSSTIKSDVWSFGILLMEI 427 Query: 395 IT-GTLPFLG 421 +T G +P+ G Sbjct: 428 VTYGRIPYPG 437
>IKKB_DROME (Q9VEZ5) Inhibitor of nuclear factor kappa B kinase beta subunit| (EC 2.7.11.1) (DmIKK-beta) (Immune response deficient protein 5) (IKK-like protein) (Lipopolysaccharide-activated kinase) (DLAK) (Cactus kinase IKK) Length = 751 Score = 87.0 bits (214), Expect = 2e-17 Identities = 50/132 (37%), Positives = 74/132 (56%), Gaps = 6/132 (4%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVAR-GMAYVHG-LGFIHRDLKSDNLL 214 IV Y GG VR L +N + + V+Q L R + ++H G HRDLK DN++ Sbjct: 132 IVLEYCNGGDVRKRLQSPENANGLTEFEVRQILGALRKALHFLHSQCGICHRDLKPDNIV 191 Query: 215 IS----GDKSIKIADFGVARIEVKTEGMTPETGTYRWMAPEMIQHRPYNQKVDVYSFGIV 382 I G K K+ DFG+AR + GT + APE++++ YN VD++SFG++ Sbjct: 192 IQRGVDGKKIYKLTDFGLARGTPDQTMVQSVVGTRHYYAPEVVENGFYNSTVDLWSFGVI 251 Query: 383 LWELITGTLPFL 418 +EL+TG LPF+ Sbjct: 252 AYELVTGELPFI 263
>SRC_RSVSA (P00524) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 87.0 bits (214), Expect = 2e-17 Identities = 51/135 (37%), Positives = 76/135 (56%), Gaps = 4/135 (2%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLIS 220 IVT Y GS+ +FL + + L V A +A GMAYV + ++HRDL++ N+L+ Sbjct: 335 IVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVG 394 Query: 221 GDKSIKIADFGVARIEVKTEGMTPETGT---YRWMAPEMIQHRPYNQKVDVYSFGIVLWE 391 + K+ADFG+AR+ ++ T G +W APE + + K DV+SFGI+L E Sbjct: 395 ENLVCKVADFGLARL-IEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTE 453 Query: 392 LIT-GTLPFLGGRGG 433 L T G +P+ G G Sbjct: 454 LTTKGRVPYPGMGNG 468
>SRC_AVISR (P00525) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 87.0 bits (214), Expect = 2e-17 Identities = 51/135 (37%), Positives = 76/135 (56%), Gaps = 4/135 (2%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLIS 220 IVT Y GS+ +FL + + L V A +A GMAYV + ++HRDL++ N+L+ Sbjct: 335 IVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVG 394 Query: 221 GDKSIKIADFGVARIEVKTEGMTPETGT---YRWMAPEMIQHRPYNQKVDVYSFGIVLWE 391 + K+ADFG+AR+ ++ T G +W APE + + K DV+SFGI+L E Sbjct: 395 ENLVCKVADFGLARL-IEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTE 453 Query: 392 LIT-GTLPFLGGRGG 433 L T G +P+ G G Sbjct: 454 LTTKGRVPYPGMGNG 468
>TESK1_MOUSE (O70146) Dual specificity testis-specific protein kinase 1 (EC| 2.7.12.1) (Testicular protein kinase 1) Length = 627 Score = 87.0 bits (214), Expect = 2e-17 Identities = 53/140 (37%), Positives = 81/140 (57%), Gaps = 8/140 (5%) Frame = +2 Query: 2 KFVGACRKPIVWCIVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGF 181 +F+G C +T Y GG++ L+ + S P++L + ALD+A+G+ Y+H G Sbjct: 109 RFMGVCVHQGQLHALTEYMNGGTLEQLLSSPEPLSWPVRLHL--ALDIAQGLRYLHAKGV 166 Query: 182 IHRDLKSDNLLISGDK---SIKIADFGVA-RIEVKTEGMTPE----TGTYRWMAPEMIQH 337 HRDL S N L+ + + + DFG+A +I V EG E G+ WMAPE+++ Sbjct: 167 FHRDLTSKNCLVRREDRGFTAVVGDFGLAEKIPVYREGTRKEPLAVVGSPYWMAPEVLRG 226 Query: 338 RPYNQKVDVYSFGIVLWELI 397 Y++K DV++FGIVL ELI Sbjct: 227 ELYDEKADVFAFGIVLCELI 246
>SRMS_MOUSE (Q62270) Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70)| Length = 496 Score = 86.7 bits (213), Expect = 2e-17 Identities = 48/131 (36%), Positives = 81/131 (61%), Gaps = 4/131 (3%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLIS 220 IVT G+++ +L + +++ L + A VA GM+Y+ +HRDL + N+L+ Sbjct: 304 IVTELMGKGNLQVYLGSSEGKALSLPHLLGFACQVAEGMSYLEERRVVHRDLAARNVLVG 363 Query: 221 GDKSIKIADFGVARIEVKTEGMTPETGT---YRWMAPEMIQHRPYNQKVDVYSFGIVLWE 391 D + K+ADFG+AR+ +K + +P +G+ +W APE +R ++QK DV+SFGI+L+E Sbjct: 364 DDLTCKVADFGLARL-LKDDVYSPSSGSKIPVKWTAPEAANYRVFSQKSDVWSFGILLYE 422 Query: 392 LIT-GTLPFLG 421 + T G P+ G Sbjct: 423 VFTYGQCPYEG 433
>SRC_AVISS (P14084) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 567 Score = 86.7 bits (213), Expect = 2e-17 Identities = 50/131 (38%), Positives = 75/131 (57%), Gaps = 4/131 (3%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLIS 220 IVT Y GS+ +FL + + L V A +A GMAYV + ++HRDL++ N+L+ Sbjct: 335 IVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVG 394 Query: 221 GDKSIKIADFGVARIEVKTEGMTPETGT---YRWMAPEMIQHRPYNQKVDVYSFGIVLWE 391 + K+ADFG+AR+ ++ T G +W APE + + K DV+SFGI+L E Sbjct: 395 ENLVCKVADFGLARL-IEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTE 453 Query: 392 LIT-GTLPFLG 421 L T G +P+ G Sbjct: 454 LTTKGRVPYPG 464
>MATK_RAT (P41243) Megakaryocyte-associated tyrosine-protein kinase (EC| 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase BATK) Length = 467 Score = 86.7 bits (213), Expect = 2e-17 Identities = 45/126 (35%), Positives = 75/126 (59%), Gaps = 1/126 (0%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLIS 220 IV + G++ NFL R V ++ AL VA GM Y+ +HRDL + N+L+S Sbjct: 261 IVMEHVSKGNLVNFLRTRGRALVSTSQLLQFALHVAEGMEYLESKKLVHRDLAARNILVS 320 Query: 221 GDKSIKIADFGVARIEVKTEGMTPETGTYRWMAPEMIQHRPYNQKVDVYSFGIVLWELIT 400 D K++DFG+A+ E++ +G+ +W APE +++ ++ K DV+SFG++LWE+ + Sbjct: 321 EDLVAKVSDFGLAKAELR-KGLDSSRLPVKWTAPEALKNGRFSSKSDVWSFGVLLWEVFS 379 Query: 401 -GTLPF 415 G P+ Sbjct: 380 YGRAPY 385
>SRC_AVIS2 (P15054) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 586 Score = 86.7 bits (213), Expect = 2e-17 Identities = 50/131 (38%), Positives = 75/131 (57%), Gaps = 4/131 (3%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLIS 220 IVT Y GS+ +FL + + L V A +A GMAYV + ++HRDL++ N+L+ Sbjct: 335 IVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVG 394 Query: 221 GDKSIKIADFGVARIEVKTEGMTPETGT---YRWMAPEMIQHRPYNQKVDVYSFGIVLWE 391 + K+ADFG+AR+ ++ T G +W APE + + K DV+SFGI+L E Sbjct: 395 ENLVCKVADFGLARL-IEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTE 453 Query: 392 LIT-GTLPFLG 421 L T G +P+ G Sbjct: 454 LTTKGRVPYPG 464
>SRC_AVIST (P14085) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 556 Score = 86.7 bits (213), Expect = 2e-17 Identities = 50/131 (38%), Positives = 75/131 (57%), Gaps = 4/131 (3%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLIS 220 IVT Y GS+ +FL + + L V A +A GMAYV + ++HRDL++ N+L+ Sbjct: 335 IVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVG 394 Query: 221 GDKSIKIADFGVARIEVKTEGMTPETGT---YRWMAPEMIQHRPYNQKVDVYSFGIVLWE 391 + K+ADFG+AR+ ++ T G +W APE + + K DV+SFGI+L E Sbjct: 395 ENLVCKVADFGLARL-IEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTE 453 Query: 392 LIT-GTLPFLG 421 L T G +P+ G Sbjct: 454 LTTKGRVPYPG 464
>FGFR1_CHICK (P21804) Basic fibroblast growth factor receptor 1 precursor (EC| 2.7.10.1) Length = 819 Score = 86.7 bits (213), Expect = 2e-17 Identities = 56/160 (35%), Positives = 81/160 (50%), Gaps = 22/160 (13%) Frame = +2 Query: 8 VGACRKPIVWCIVTGYAKGGSVRNFLNRRQ--------------NRSVPLKLAVKQALDV 145 +GAC + ++ YA G++R +L R+ + K V A V Sbjct: 546 LGACTQDGPLYVIVEYASKGNLREYLQARRPPGMEYCYNPTRIPEEQLSFKDLVSCAYQV 605 Query: 146 ARGMAYVHGLGFIHRDLKSDNLLISGDKSIKIADFGVAR-------IEVKTEGMTPETGT 304 ARGM Y+ IHRDL + N+L++ D +KIADFG+AR + T G P Sbjct: 606 ARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLP---- 661 Query: 305 YRWMAPEMIQHRPYNQKVDVYSFGIVLWELIT-GTLPFLG 421 +WMAPE + R Y + DV+SFG++LWE+ T G P+ G Sbjct: 662 VKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPG 701
>FGFR3_HUMAN (P22607) Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1)| (FGFR-3) (CD333 antigen) Length = 806 Score = 86.7 bits (213), Expect = 2e-17 Identities = 57/160 (35%), Positives = 81/160 (50%), Gaps = 22/160 (13%) Frame = +2 Query: 8 VGACRKPIVWCIVTGYAKGGSVRNFLNRRQ--------------NRSVPLKLAVKQALDV 145 +GAC + ++ YA G++R FL R+ + K V A V Sbjct: 542 LGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQV 601 Query: 146 ARGMAYVHGLGFIHRDLKSDNLLISGDKSIKIADFGVAR-------IEVKTEGMTPETGT 304 ARGM Y+ IHRDL + N+L++ D +KIADFG+AR + T G P Sbjct: 602 ARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLP---- 657 Query: 305 YRWMAPEMIQHRPYNQKVDVYSFGIVLWELIT-GTLPFLG 421 +WMAPE + R Y + DV+SFG++LWE+ T G P+ G Sbjct: 658 VKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPG 697
>SRC_CHICK (P00523) Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2)| (p60-Src) (c-Src) (pp60c-src) Length = 532 Score = 86.7 bits (213), Expect = 2e-17 Identities = 50/131 (38%), Positives = 75/131 (57%), Gaps = 4/131 (3%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLIS 220 IVT Y GS+ +FL + + L V A +A GMAYV + ++HRDL++ N+L+ Sbjct: 335 IVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVG 394 Query: 221 GDKSIKIADFGVARIEVKTEGMTPETGT---YRWMAPEMIQHRPYNQKVDVYSFGIVLWE 391 + K+ADFG+AR+ ++ T G +W APE + + K DV+SFGI+L E Sbjct: 395 ENLVCKVADFGLARL-IEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTE 453 Query: 392 LIT-GTLPFLG 421 L T G +P+ G Sbjct: 454 LTTKGRVPYPG 464
>SRK3_SPOLA (P42689) Tyrosine-protein kinase SRK3 (EC 2.7.10.2) (Fragment)| Length = 334 Score = 86.3 bits (212), Expect = 3e-17 Identities = 46/131 (35%), Positives = 75/131 (57%), Gaps = 4/131 (3%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLIS 220 IVT K GS+ +L + +++ L V + +A GM Y+ +IHRDL + N+L+ Sbjct: 136 IVTELMKYGSMLEYLKHGEGKNITLHQMVDMSAQIASGMTYLEAHSYIHRDLAARNILVG 195 Query: 221 GDKSIKIADFGVARIEVKTEGMTPETGT---YRWMAPEMIQHRPYNQKVDVYSFGIVLWE 391 K+ADFG+AR+ +K + P GT +W APE + + K DV+SFG+++ E Sbjct: 196 EGNVCKVADFGLARV-IKEDIYNPREGTKFPIKWTAPEAALYNRFTIKSDVWSFGVLISE 254 Query: 392 LIT-GTLPFLG 421 ++T G +P+ G Sbjct: 255 IVTHGRMPYPG 265
>BTK_CHICK (Q8JH64) Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton's| tyrosine kinase) Length = 657 Score = 86.3 bits (212), Expect = 3e-17 Identities = 47/139 (33%), Positives = 77/139 (55%), Gaps = 4/139 (2%) Frame = +2 Query: 11 GACRKPIVWCIVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHR 190 G C K I+T Y G + NFL Q R P +L ++ DV M Y+ F+HR Sbjct: 460 GVCTKQRPIFIITEYMANGCLLNFLRETQRRFQPAEL-LEMCKDVCEAMEYLESKQFLHR 518 Query: 191 DLKSDNLLISGDKSIKIADFGVARIEVKTEGMTPETGT---YRWMAPEMIQHRPYNQKVD 361 DL + N L++ +K++DFG++R + E T G+ RW PE++ + ++ K D Sbjct: 519 DLAARNCLVNDQGIVKVSDFGLSRYVLDDE-YTSSMGSKFPVRWSPPEVLLYSKFSSKSD 577 Query: 362 VYSFGIVLWELIT-GTLPF 415 V+SFG+++WE+ + G +P+ Sbjct: 578 VWSFGVLMWEVYSLGKMPY 596
>MET_HUMAN (P08581) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1390 Score = 86.3 bits (212), Expect = 3e-17 Identities = 48/129 (37%), Positives = 73/129 (56%), Gaps = 5/129 (3%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLIS 220 +V Y K G +RNF+ R + + +K + L VA+GM Y+ F+HRDL + N ++ Sbjct: 1155 VVLPYMKHGDLRNFI-RNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLD 1213 Query: 221 GDKSIKIADFGVARIEVKTEGMTPETGT-----YRWMAPEMIQHRPYNQKVDVYSFGIVL 385 ++K+ADFG+AR E + T +WMA E +Q + + K DV+SFG+VL Sbjct: 1214 EKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVVL 1273 Query: 386 WELITGTLP 412 WEL+T P Sbjct: 1274 WELMTRGAP 1282
>BLK_HUMAN (P51451) Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte| kinase) (p55-BLK) Length = 504 Score = 86.3 bits (212), Expect = 3e-17 Identities = 49/130 (37%), Positives = 75/130 (57%), Gaps = 3/130 (2%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLIS 220 IVT Y G + +FL + + L + + +A GMAY+ + IHRDL++ N+L+S Sbjct: 309 IVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGMAYIERMNSIHRDLRAANILVS 368 Query: 221 GDKSIKIADFGVARIEVKTEGMTPETGTY--RWMAPEMIQHRPYNQKVDVYSFGIVLWEL 394 KIADFG+ARI + +E E + +W APE I + K DV+SFG++L E+ Sbjct: 369 EALCCKIADFGLARI-IDSEYTAQEGAKFPIKWTAPEAIHFGVFTIKADVWSFGVLLMEV 427 Query: 395 IT-GTLPFLG 421 +T G +P+ G Sbjct: 428 VTYGRVPYPG 437
>FGFR3_MOUSE (Q61851) Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1)| (FGFR-3) (Heparin-binding growth factor receptor) Length = 801 Score = 86.3 bits (212), Expect = 3e-17 Identities = 57/161 (35%), Positives = 81/161 (50%), Gaps = 23/161 (14%) Frame = +2 Query: 8 VGACRKPIVWCIVTGYAKGGSVRNFLNRRQ--------------NRSVPLKLAVKQALDV 145 +GAC + ++ YA G++R FL R+ + K V A V Sbjct: 536 LGACTQGGPLYVLVEYAAKGNLREFLRARRPPGMDYSFDACRLPEEQLTCKDLVSCAYQV 595 Query: 146 ARGMAYVHGLGFIHRDLKSDNLLISGDKSIKIADFGVAR-------IEVKTEGMTPETGT 304 ARGM Y+ IHRDL + N+L++ D +KIADFG+AR + T G P Sbjct: 596 ARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLP---- 651 Query: 305 YRWMAPEMIQHRPYNQKVDVYSFGIVLWELIT--GTLPFLG 421 +WMAPE + R Y + DV+SFG++LWE+ T G P+ G Sbjct: 652 VKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTPGGPSPYPG 692
>MATK_HUMAN (P42679) Megakaryocyte-associated tyrosine-protein kinase (EC| 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase) Length = 507 Score = 86.3 bits (212), Expect = 3e-17 Identities = 46/126 (36%), Positives = 72/126 (57%), Gaps = 1/126 (0%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLIS 220 IV + G++ NFL R V ++ +L VA GM Y+ +HRDL + N+L+S Sbjct: 302 IVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLAARNILVS 361 Query: 221 GDKSIKIADFGVARIEVKTEGMTPETGTYRWMAPEMIQHRPYNQKVDVYSFGIVLWELIT 400 D K++DFG+A+ E K G+ +W APE ++H + K DV+SFG++LWE+ + Sbjct: 362 EDLVAKVSDFGLAKAERK--GLDSSRLPVKWTAPEALKHGKFTSKSDVWSFGVLLWEVFS 419 Query: 401 -GTLPF 415 G P+ Sbjct: 420 YGRAPY 425
>CEK2_CHICK (P18460) Tyrosine kinase receptor CEK2 precursor (EC 2.7.10.1)| Length = 806 Score = 86.3 bits (212), Expect = 3e-17 Identities = 56/160 (35%), Positives = 81/160 (50%), Gaps = 22/160 (13%) Frame = +2 Query: 8 VGACRKPIVWCIVTGYAKGGSVRNFLNRRQ--------------NRSVPLKLAVKQALDV 145 +GAC + ++ YA G++R +L R+ + K V A V Sbjct: 536 LGACTQDGPLYVLVEYASKGNLREYLRARRPPGMDYSFDTCKLPEEQLTFKDLVSCAYQV 595 Query: 146 ARGMAYVHGLGFIHRDLKSDNLLISGDKSIKIADFGVAR-------IEVKTEGMTPETGT 304 ARGM Y+ IHRDL + N+L++ D +KIADFG+AR + T G P Sbjct: 596 ARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNIDYYKKTTNGRLP---- 651 Query: 305 YRWMAPEMIQHRPYNQKVDVYSFGIVLWELIT-GTLPFLG 421 +WMAPE + R Y + DV+SFG++LWE+ T G P+ G Sbjct: 652 VKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPG 691
>EPHA7_CHICK (O42422) Ephrin type-A receptor 7 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor CEPHA7) (Tyrosine-protein kinase receptor CEK11) Length = 993 Score = 86.3 bits (212), Expect = 3e-17 Identities = 49/136 (36%), Positives = 82/136 (60%), Gaps = 5/136 (3%) Frame = +2 Query: 23 KPIVWCIVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKS 202 KP++ IV Y + G++ FL + + ++L V +A GM Y+ +G++HRDL + Sbjct: 700 KPVM--IVIEYMENGALDAFLRKHDGQFTVIQL-VGMLRGIAAGMRYLADMGYVHRDLAA 756 Query: 203 DNLLISGDKSIKIADFGVAR-IEVKTEGMTPETG---TYRWMAPEMIQHRPYNQKVDVYS 370 N+L++ + K++DFG++R IE E + TG RW APE IQ+R + DV+S Sbjct: 757 RNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPEAIQYRKFTSASDVWS 816 Query: 371 FGIVLWELIT-GTLPF 415 +GIV+WE+++ G P+ Sbjct: 817 YGIVMWEVMSYGERPY 832
>SRC_HUMAN (P12931) Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2)| (p60-Src) (c-Src) (pp60c-src) Length = 535 Score = 86.3 bits (212), Expect = 3e-17 Identities = 50/131 (38%), Positives = 75/131 (57%), Gaps = 4/131 (3%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLIS 220 IVT Y GS+ +FL + + L V A +A GMAYV + ++HRDL++ N+L+ Sbjct: 338 IVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVG 397 Query: 221 GDKSIKIADFGVARIEVKTEGMTPETGT---YRWMAPEMIQHRPYNQKVDVYSFGIVLWE 391 + K+ADFG+AR+ ++ T G +W APE + + K DV+SFGI+L E Sbjct: 398 ENLVCKVADFGLARL-IEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTE 456 Query: 392 LIT-GTLPFLG 421 L T G +P+ G Sbjct: 457 LTTKGRVPYPG 467
>GIN4_YEAST (Q12263) Serine/threonine-protein kinase GIN4 (EC 2.7.11.1)| Length = 1142 Score = 86.3 bits (212), Expect = 3e-17 Identities = 48/126 (38%), Positives = 75/126 (59%), Gaps = 1/126 (0%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLIS 220 +V YA+ G + N L R +P A++ + G++Y H LG +HRDLK +NLL+ Sbjct: 108 LVLEYAEKGELFNLLVERG--PLPEHEAIRFFRQIIIGVSYCHALGIVHRDLKPENLLLD 165 Query: 221 GDKSIKIADFGVARIEVKTEGMTPETGTYRWMAPEMIQHRPYNQ-KVDVYSFGIVLWELI 397 +IKIADFG+A +E + + + G+ + APE++ PY DV+S G++L+ L+ Sbjct: 166 HKYNIKIADFGMAALETEGKLLETSCGSPHYAAPEIVSGIPYQGFASDVWSCGVILFALL 225 Query: 398 TGTLPF 415 TG LPF Sbjct: 226 TGRLPF 231
>SHK2_SCHPO (Q10056) Serine/threonine-protein kinase shk2 (EC 2.7.11.1)| Length = 589 Score = 86.3 bits (212), Expect = 3e-17 Identities = 45/134 (33%), Positives = 75/134 (55%), Gaps = 1/134 (0%) Frame = +2 Query: 20 RKPIVWCIVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLK 199 R+ +W +V Y GS+ + + + + + + L+ +G+ ++H IHRD+K Sbjct: 381 RERHLW-VVMEYMNAGSLTDIIEKSKLTEAQI---ARICLETCKGIQHLHARNIIHRDIK 436 Query: 200 SDNLLISGDKSIKIADFGV-ARIEVKTEGMTPETGTYRWMAPEMIQHRPYNQKVDVYSFG 376 SDN+L+ +IKI DFG AR+ +T GT WMAPE+++ Y KVD++S G Sbjct: 437 SDNVLLDNSGNIKITDFGFCARLSNRTNKRVTMVGTPYWMAPEVVKQNEYGTKVDIWSLG 496 Query: 377 IVLWELITGTLPFL 418 I++ E+I P+L Sbjct: 497 IMIIEMIENEPPYL 510
>SRC42_DROME (Q9V9J3) Tyrosine-protein kinase Src42A (EC 2.7.10.2) (Dsrc41)| Length = 517 Score = 85.9 bits (211), Expect = 4e-17 Identities = 49/132 (37%), Positives = 76/132 (57%), Gaps = 5/132 (3%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNR--RQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLL 214 I+T K GS+ +L + RS+ ++ + A +A GMAY+ +IHRDL + N+L Sbjct: 318 IITELMKHGSLLEYLQAIAGKGRSLKMQTLIDMAAQIAAGMAYLESQNYIHRDLAARNVL 377 Query: 215 ISGDKSIKIADFGVARI--EVKTEGMTPETGTYRWMAPEMIQHRPYNQKVDVYSFGIVLW 388 + +KIADFG+AR+ E + E +W APE + ++ K DV+SFGI+L Sbjct: 378 VGDGNIVKIADFGLARLIKEDEYEARVGARFPIKWTAPEAANYSKFSIKSDVWSFGILLT 437 Query: 389 ELIT-GTLPFLG 421 EL+T G +P+ G Sbjct: 438 ELVTYGRIPYPG 449
>MET_OTOGA (Q2QLH6) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1382 Score = 85.9 bits (211), Expect = 4e-17 Identities = 47/129 (36%), Positives = 74/129 (57%), Gaps = 5/129 (3%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLIS 220 +V Y K G +RNF+ R + + +K + L VA+GM Y+ F+HRDL + N ++ Sbjct: 1156 VVLPYMKHGDLRNFI-RNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLD 1214 Query: 221 GDKSIKIADFGVARIEVKTEGMTPETGT-----YRWMAPEMIQHRPYNQKVDVYSFGIVL 385 + ++K+ADFG+AR E + T +WMA E +Q + + K DV+SFG++L Sbjct: 1215 ENFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLL 1274 Query: 386 WELITGTLP 412 WEL+T P Sbjct: 1275 WELMTRGAP 1283
>FRK_HUMAN (P42685) Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear| tyrosine protein kinase RAK) Length = 505 Score = 85.9 bits (211), Expect = 4e-17 Identities = 50/136 (36%), Positives = 76/136 (55%), Gaps = 6/136 (4%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLIS 220 I+T + GS++ +L + L V A VA GMAY+ +IHRDL + N+L+ Sbjct: 304 IITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAYLESRNYIHRDLAARNVLVG 363 Query: 221 GDKSIKIADFGVARI-EVKTEGMTPETG----TYRWMAPEMIQHRPYNQKVDVYSFGIVL 385 K+ADFG+AR+ +V E + +W APE I+ ++ K DV+SFGI+L Sbjct: 364 EHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTAPEAIRSNKFSIKSDVWSFGILL 423 Query: 386 WELIT-GTLPFLGGRG 430 +E+IT G +P+ G G Sbjct: 424 YEIITYGKMPYSGMTG 439
>FGFR1_MOUSE (P16092) Basic fibroblast growth factor receptor 1 precursor (EC| 2.7.10.1) (FGFR-1) (bFGF-R) (MFR) Length = 822 Score = 85.9 bits (211), Expect = 4e-17 Identities = 56/160 (35%), Positives = 81/160 (50%), Gaps = 22/160 (13%) Frame = +2 Query: 8 VGACRKPIVWCIVTGYAKGGSVRNFLNRRQ--------------NRSVPLKLAVKQALDV 145 +GAC + ++ YA G++R +L R+ + K V A V Sbjct: 548 LGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQV 607 Query: 146 ARGMAYVHGLGFIHRDLKSDNLLISGDKSIKIADFGVAR-------IEVKTEGMTPETGT 304 ARGM Y+ IHRDL + N+L++ D +KIADFG+AR + T G P Sbjct: 608 ARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLP---- 663 Query: 305 YRWMAPEMIQHRPYNQKVDVYSFGIVLWELIT-GTLPFLG 421 +WMAPE + R Y + DV+SFG++LWE+ T G P+ G Sbjct: 664 VKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPG 703
>FGFR1_HUMAN (P11362) Basic fibroblast growth factor receptor 1 precursor (EC| 2.7.10.1) (FGFR-1) (bFGF-R) (Fms-like tyrosine kinase 2) (c-fgr) (CD331 antigen) Length = 822 Score = 85.9 bits (211), Expect = 4e-17 Identities = 56/160 (35%), Positives = 81/160 (50%), Gaps = 22/160 (13%) Frame = +2 Query: 8 VGACRKPIVWCIVTGYAKGGSVRNFLNRRQ--------------NRSVPLKLAVKQALDV 145 +GAC + ++ YA G++R +L R+ + K V A V Sbjct: 548 LGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQV 607 Query: 146 ARGMAYVHGLGFIHRDLKSDNLLISGDKSIKIADFGVAR-------IEVKTEGMTPETGT 304 ARGM Y+ IHRDL + N+L++ D +KIADFG+AR + T G P Sbjct: 608 ARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLP---- 663 Query: 305 YRWMAPEMIQHRPYNQKVDVYSFGIVLWELIT-GTLPFLG 421 +WMAPE + R Y + DV+SFG++LWE+ T G P+ G Sbjct: 664 VKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPG 703
>BLK_MOUSE (P16277) Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte| kinase) (p55-BLK) Length = 498 Score = 85.9 bits (211), Expect = 4e-17 Identities = 52/137 (37%), Positives = 78/137 (56%), Gaps = 3/137 (2%) Frame = +2 Query: 20 RKPIVWCIVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLK 199 R+PI IVT Y G + +FL + + L + + VA GMAY+ + IHRDL+ Sbjct: 298 REPIY--IVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQVAEGMAYIERMNSIHRDLR 355 Query: 200 SDNLLISGDKSIKIADFGVARIEVKTEGMTPETGTY--RWMAPEMIQHRPYNQKVDVYSF 373 + N+L+S KIADFG+ARI + +E E + +W APE I + K DV+SF Sbjct: 356 AANILVSETLCCKIADFGLARI-IDSEYTAQEGAKFPIKWTAPEAIHFGVFTIKADVWSF 414 Query: 374 GIVLWELIT-GTLPFLG 421 G++L ++T G +P+ G Sbjct: 415 GVLLMVIVTYGRVPYPG 431
>YES_XENLA (P10936) Tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes)| Length = 536 Score = 85.9 bits (211), Expect = 4e-17 Identities = 50/131 (38%), Positives = 75/131 (57%), Gaps = 4/131 (3%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLIS 220 IVT Y GS+ +FL + + L V A +A GMAY+ + +IHRDL++ N+L+ Sbjct: 339 IVTEYMIKGSLLDFLKEGNGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVG 398 Query: 221 GDKSIKIADFGVARIEVKTEGMTPETGT---YRWMAPEMIQHRPYNQKVDVYSFGIVLWE 391 + KIADFG+AR+ ++ T G +W APE + + K DV+SFGI+L E Sbjct: 399 DNLVCKIADFGLARL-IEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTE 457 Query: 392 LIT-GTLPFLG 421 L+ G +P+ G Sbjct: 458 LVAKGRVPYPG 468
>CSK_CHICK (P41239) Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase)| Length = 450 Score = 85.5 bits (210), Expect = 5e-17 Identities = 47/128 (36%), Positives = 74/128 (57%), Gaps = 3/128 (2%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLIS 220 IVT Y GS+ ++L R + +K +LDV M Y+ F+HRDL + N+L+S Sbjct: 264 IVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEANNFVHRDLAARNVLVS 323 Query: 221 GDKSIKIADFGVARIEVKTEGMTPETG--TYRWMAPEMIQHRPYNQKVDVYSFGIVLWEL 394 D K++DFG+ K T +TG +W APE ++ + ++ K DV+SFGI+LWE+ Sbjct: 324 EDNIAKVSDFGL----TKEASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEI 379 Query: 395 IT-GTLPF 415 + G +P+ Sbjct: 380 YSFGRVPY 387
>KRAF1_CAEEL (Q07292) Raf homolog serine/threonine-protein kinase (EC 2.7.11.1)| (Abnormal cell lineage protein 45) Length = 813 Score = 85.5 bits (210), Expect = 5e-17 Identities = 50/147 (34%), Positives = 84/147 (57%), Gaps = 10/147 (6%) Frame = +2 Query: 5 FVGACRKPIVWCIVTGYAKGGSVRNFLNRRQNR-SVPLKLAVKQALDVARGMAYVHGLGF 181 F+G R+P + I+T + +G S+ ++ ++ R + + V+ GM Y+H Sbjct: 540 FMGWVREPEI-AIITQWCEGSSLYRHIHVQEPRVEFEMGAIIDILKQVSLGMNYLHSKNI 598 Query: 182 IHRDLKSDNLLISGDKS-IKIADFGVARIEVK-----TEGMTPETGTYRWMAPEMIQ--- 334 IHRDLK++N+ + D S +KI DFG+A ++ K + TG+ WMAPE+I+ Sbjct: 599 IHRDLKTNNIFLMDDMSTVKIGDFGLATVKTKWTVNGGQQQQQPTGSILWMAPEVIRMQD 658 Query: 335 HRPYNQKVDVYSFGIVLWELITGTLPF 415 PY + DVYSFGI ++E+++ LP+ Sbjct: 659 DNPYTPQSDVYSFGICMYEILSSHLPY 685
>SHK1_SCHPO (P50527) Serine/threonine-protein kinase pak1/shk1 (EC 2.7.11.1)| Length = 658 Score = 85.5 bits (210), Expect = 5e-17 Identities = 47/133 (35%), Positives = 74/133 (55%), Gaps = 1/133 (0%) Frame = +2 Query: 23 KPIVWCIVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKS 202 K +W ++ Y +GGS+ + + K+ L+ G+ ++H G +HRD+KS Sbjct: 453 KSELWMVME-YMRGGSLTEVVTNNTLSEGQIAAICKETLE---GLQHLHENGIVHRDIKS 508 Query: 203 DNLLISGDKSIKIADFGV-ARIEVKTEGMTPETGTYRWMAPEMIQHRPYNQKVDVYSFGI 379 DN+L+S IK+ DFG A+I+ T GT WMAPE++ + Y KVDV+S GI Sbjct: 509 DNILLSLQGDIKLTDFGFCAQIDSNMTKRTTMVGTPYWMAPEVVTRKEYGFKVDVWSLGI 568 Query: 380 VLWELITGTLPFL 418 + E++ G P+L Sbjct: 569 MAIEMVEGEPPYL 581
>PAK7_HUMAN (Q9P286) Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1)| (p21-activated kinase 7) (PAK-7) (PAK-5) Length = 719 Score = 85.5 bits (210), Expect = 5e-17 Identities = 43/126 (34%), Positives = 73/126 (57%), Gaps = 1/126 (0%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLIS 220 +V + +GG++ + + + + L V R ++Y+H G IHRD+KSD++L++ Sbjct: 521 VVMEFLEGGALTDIVTHTRMNEEQIATV---CLSVLRALSYLHNQGVIHRDIKSDSILLT 577 Query: 221 GDKSIKIADFG-VARIEVKTEGMTPETGTYRWMAPEMIQHRPYNQKVDVYSFGIVLWELI 397 D IK++DFG A++ + GT WMAPE+I PY +VD++S GI++ E+I Sbjct: 578 SDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMI 637 Query: 398 TGTLPF 415 G P+ Sbjct: 638 DGEPPY 643
>MATK_MOUSE (P41242) Megakaryocyte-associated tyrosine-protein kinase (EC| 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK) Length = 505 Score = 85.5 bits (210), Expect = 5e-17 Identities = 46/126 (36%), Positives = 73/126 (57%), Gaps = 1/126 (0%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLIS 220 IV + G++ NFL R V ++ AL VA GM Y+ +HRDL + N+L+S Sbjct: 300 IVMEHVSKGNLVNFLRTRGRALVSTSQLLQFALHVAEGMEYLESKKLVHRDLAARNILVS 359 Query: 221 GDKSIKIADFGVARIEVKTEGMTPETGTYRWMAPEMIQHRPYNQKVDVYSFGIVLWELIT 400 D K++DFG+A+ E K G+ +W APE +++ ++ K DV+SFG++LWE+ + Sbjct: 360 EDLVAKVSDFGLAKAERK--GLDSSRLPVKWTAPEALKNGRFSSKSDVWSFGVLLWEVFS 417 Query: 401 -GTLPF 415 G P+ Sbjct: 418 YGRAPY 423
>YES_XIPHE (P27447) Tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes)| Length = 543 Score = 85.5 bits (210), Expect = 5e-17 Identities = 49/131 (37%), Positives = 77/131 (58%), Gaps = 4/131 (3%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLIS 220 IVT + GS+ +FL + + L V A +A GMA++ + +IHRDL++ N+L++ Sbjct: 346 IVTEFMGKGSLLDFLKEGDGKHLKLPQLVDMASQIADGMAFIERMNYIHRDLRAANILVA 405 Query: 221 GDKSIKIADFGVARIEVKTEGMTPETGT---YRWMAPEMIQHRPYNQKVDVYSFGIVLWE 391 + KIADFG+AR+ ++ T G +W APE + + K DV+SFGI+L E Sbjct: 406 DNLVCKIADFGLARL-IEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTE 464 Query: 392 LIT-GTLPFLG 421 L+T G +P+ G Sbjct: 465 LVTKGRVPYPG 475
>TESK2_MOUSE (Q8VCT9) Dual specificity testis-specific protein kinase 2 (EC| 2.7.12.1) (Testicular protein kinase 2) Length = 570 Score = 85.5 bits (210), Expect = 5e-17 Identities = 51/139 (36%), Positives = 79/139 (56%), Gaps = 7/139 (5%) Frame = +2 Query: 2 KFVGACRKPIVWCIVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGF 181 +F+G C +T Y G++ L+ + +P + VK A D+A G++Y+H G Sbjct: 115 RFMGVCVHQGQLHALTEYINSGNLEQLLD--SDLYLPWTVRVKLAYDIAVGLSYLHFKGI 172 Query: 182 IHRDLKSDNLLISGDK---SIKIADFGVARIEVKTEGMTPE----TGTYRWMAPEMIQHR 340 HRDL S N LI D+ S +ADFG+A ++ + E G+ WMAPE+++ Sbjct: 173 FHRDLTSKNCLIKRDENGYSAVVADFGLAE-KIPDASIGREKLAVVGSPFWMAPEVLRDE 231 Query: 341 PYNQKVDVYSFGIVLWELI 397 PYN+K DV+S+GI+L E+I Sbjct: 232 PYNEKADVFSYGIILCEII 250
>BCK1_YEAST (Q01389) Serine/threonine-protein kinase BCK1/SLK1/SSP31 (EC| 2.7.11.1) Length = 1478 Score = 85.5 bits (210), Expect = 5e-17 Identities = 48/142 (33%), Positives = 79/142 (55%), Gaps = 4/142 (2%) Frame = +2 Query: 2 KFVGACRKPIVWCIVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQ-ALDVARGMAYVHGLG 178 +++G K ++ + Y GGSV + + PL +K V +G+AY+H G Sbjct: 1242 QYLGFENKNNIYSLFLEYVAGGSVGSLIRMYGRFDEPL---IKHLTTQVLKGLAYLHSKG 1298 Query: 179 FIHRDLKSDNLLISGDKSIKIADFGVAR--IEVKTEGMTPETGTYRWMAPEMIQHRP-YN 349 +HRD+K+DNLL+ D KI+DFG++R ++ + GT WMAPEM+ + Y+ Sbjct: 1299 ILHRDMKADNLLLDQDGICKISDFGISRKSKDIYSNSDMTMRGTVFWMAPEMVDTKQGYS 1358 Query: 350 QKVDVYSFGIVLWELITGTLPF 415 KVD++S G ++ E+ G P+ Sbjct: 1359 AKVDIWSLGCIVLEMFAGKRPW 1380
>SRC_RSVPA (P31693) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 522 Score = 85.1 bits (209), Expect = 7e-17 Identities = 49/131 (37%), Positives = 75/131 (57%), Gaps = 4/131 (3%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLIS 220 IV Y GS+ +FL + + L V+ A +A GMAYV + ++HRDL++ N+L+ Sbjct: 332 IVIEYMSKGSLLDFLKGEMGKYLRLPQLVEMAAQIASGMAYVERMNYVHRDLRAANILVG 391 Query: 221 GDKSIKIADFGVARIEVKTEGMTPETGT---YRWMAPEMIQHRPYNQKVDVYSFGIVLWE 391 + K+ADFG+AR+ ++ T G +W APE + + K DV+SFGI+L E Sbjct: 392 ENLVCKVADFGLARL-IEDNEYTARPGARFPVKWTAPEAALYGRFTIKSDVWSFGILLTE 450 Query: 392 LIT-GTLPFLG 421 L T G +P+ G Sbjct: 451 LTTKGRVPYPG 461
>EPHA5_RAT (P54757) Ephrin type-A receptor 5 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) Length = 1005 Score = 85.1 bits (209), Expect = 7e-17 Identities = 49/136 (36%), Positives = 79/136 (58%), Gaps = 5/136 (3%) Frame = +2 Query: 23 KPIVWCIVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKS 202 KP++ IVT Y + GS+ FL + + ++L V +A GM Y+ +G++HRDL + Sbjct: 749 KPVM--IVTEYMENGSLDTFLKKNDGQFTVIQL-VGMLRGIAAGMKYLSDMGYVHRDLAA 805 Query: 203 DNLLISGDKSIKIADFGVARI-EVKTEGMTPETG---TYRWMAPEMIQHRPYNQKVDVYS 370 N+LI+ + K++DFG++R+ E E G RW APE I R + DV+S Sbjct: 806 RNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAFRKFTSASDVWS 865 Query: 371 FGIVLWELIT-GTLPF 415 +GIV+WE+++ G P+ Sbjct: 866 YGIVMWEVVSYGERPY 881
>CDC15_YEAST (P27636) Cell division control protein 15 (EC 2.7.11.1)| Length = 974 Score = 85.1 bits (209), Expect = 7e-17 Identities = 53/143 (37%), Positives = 81/143 (56%), Gaps = 5/143 (3%) Frame = +2 Query: 2 KFVGACRKPIVWCIVTGYAKGGSVRNFLNRR-----QNRSVPLKLAVKQALDVARGMAYV 166 K+ G RK I+ Y GS+R ++R +N S K V Q L G+ Y+ Sbjct: 84 KYHGFIRKSYELYILLEYCANGSLRRLISRSSTGLSENES---KTYVTQTL---LGLKYL 137 Query: 167 HGLGFIHRDLKSDNLLISGDKSIKIADFGVARIEVKTEGMTPETGTYRWMAPEMIQHRPY 346 HG G IHRD+K+ N+L+S D ++K+ADFGV+ I V + +T GT WMAPE++ +R Sbjct: 138 HGEGVIHRDIKAANILLSADNTVKLADFGVSTI-VNSSALT-LAGTLNWMAPEILGNRGA 195 Query: 347 NQKVDVYSFGIVLWELITGTLPF 415 + D++S G + E++T P+ Sbjct: 196 STLSDIWSLGATVVEMLTKNPPY 218
>MET_PONPY (Q2IBD8) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1390 Score = 85.1 bits (209), Expect = 7e-17 Identities = 47/129 (36%), Positives = 73/129 (56%), Gaps = 5/129 (3%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLIS 220 +V Y K G +RNF+ R + + +K + L VA+GM Y+ F+HRDL + N ++ Sbjct: 1155 VVLPYMKHGDLRNFI-RNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLD 1213 Query: 221 GDKSIKIADFGVARIEVKTEGMTPETGT-----YRWMAPEMIQHRPYNQKVDVYSFGIVL 385 ++K+ADFG+AR E + T +WMA E +Q + + K DV+SFG++L Sbjct: 1214 EKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLL 1273 Query: 386 WELITGTLP 412 WEL+T P Sbjct: 1274 WELMTRGAP 1282
>MET_PANTR (Q2QLF1) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1390 Score = 85.1 bits (209), Expect = 7e-17 Identities = 47/129 (36%), Positives = 73/129 (56%), Gaps = 5/129 (3%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLIS 220 +V Y K G +RNF+ R + + +K + L VA+GM Y+ F+HRDL + N ++ Sbjct: 1155 VVLPYMKHGDLRNFI-RNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLD 1213 Query: 221 GDKSIKIADFGVARIEVKTEGMTPETGT-----YRWMAPEMIQHRPYNQKVDVYSFGIVL 385 ++K+ADFG+AR E + T +WMA E +Q + + K DV+SFG++L Sbjct: 1214 EKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLL 1273 Query: 386 WELITGTLP 412 WEL+T P Sbjct: 1274 WELMTRGAP 1282
>MET_MICMU (Q2QL89) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1382 Score = 85.1 bits (209), Expect = 7e-17 Identities = 47/129 (36%), Positives = 73/129 (56%), Gaps = 5/129 (3%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLIS 220 +V Y K G +RNF+ R + + +K + L VA+GM Y+ F+HRDL + N ++ Sbjct: 1156 VVLPYMKHGDLRNFI-RNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLD 1214 Query: 221 GDKSIKIADFGVARIEVKTEGMTPETGT-----YRWMAPEMIQHRPYNQKVDVYSFGIVL 385 ++K+ADFG+AR E + T +WMA E +Q + + K DV+SFG++L Sbjct: 1215 EKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLL 1274 Query: 386 WELITGTLP 412 WEL+T P Sbjct: 1275 WELMTRGAP 1283
>MET_CANFA (Q75ZY9) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1382 Score = 85.1 bits (209), Expect = 7e-17 Identities = 47/129 (36%), Positives = 73/129 (56%), Gaps = 5/129 (3%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLIS 220 +V Y K G +RNF+ R + + +K + L VA+GM Y+ F+HRDL + N ++ Sbjct: 1156 VVLPYMKHGDLRNFI-RNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLD 1214 Query: 221 GDKSIKIADFGVARIEVKTEGMTPETGT-----YRWMAPEMIQHRPYNQKVDVYSFGIVL 385 ++K+ADFG+AR E + T +WMA E +Q + + K DV+SFG++L Sbjct: 1215 EKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLL 1274 Query: 386 WELITGTLP 412 WEL+T P Sbjct: 1275 WELMTRGAP 1283
>MET_MOUSE (P16056) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1379 Score = 85.1 bits (209), Expect = 7e-17 Identities = 47/129 (36%), Positives = 73/129 (56%), Gaps = 5/129 (3%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLIS 220 +V Y K G +RNF+ R + + +K + L VA+GM Y+ F+HRDL + N ++ Sbjct: 1153 VVLPYMKHGDLRNFI-RNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLD 1211 Query: 221 GDKSIKIADFGVARIEVKTEGMTPETGT-----YRWMAPEMIQHRPYNQKVDVYSFGIVL 385 ++K+ADFG+AR E + T +WMA E +Q + + K DV+SFG++L Sbjct: 1212 EKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLL 1271 Query: 386 WELITGTLP 412 WEL+T P Sbjct: 1272 WELMTRGAP 1280
>MET_PIG (Q2QLE0) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1381 Score = 85.1 bits (209), Expect = 7e-17 Identities = 47/129 (36%), Positives = 73/129 (56%), Gaps = 5/129 (3%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLIS 220 +V Y K G +RNF+ R + + +K + L VA+GM Y+ F+HRDL + N ++ Sbjct: 1155 VVLPYMKHGDLRNFI-RNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLD 1213 Query: 221 GDKSIKIADFGVARIEVKTEGMTPETGT-----YRWMAPEMIQHRPYNQKVDVYSFGIVL 385 ++K+ADFG+AR E + T +WMA E +Q + + K DV+SFG++L Sbjct: 1214 EKFTVKVADFGLARDVYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLL 1273 Query: 386 WELITGTLP 412 WEL+T P Sbjct: 1274 WELMTRGAP 1282
>MET_HORSE (Q2QLA9) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1381 Score = 85.1 bits (209), Expect = 7e-17 Identities = 47/129 (36%), Positives = 73/129 (56%), Gaps = 5/129 (3%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLIS 220 +V Y K G +RNF+ R + + +K + L VA+GM Y+ F+HRDL + N ++ Sbjct: 1155 VVLPYMKHGDLRNFI-RNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLD 1213 Query: 221 GDKSIKIADFGVARIEVKTEGMTPETGT-----YRWMAPEMIQHRPYNQKVDVYSFGIVL 385 ++K+ADFG+AR E + T +WMA E +Q + + K DV+SFG++L Sbjct: 1214 EKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLL 1273 Query: 386 WELITGTLP 412 WEL+T P Sbjct: 1274 WELMTRGAP 1282
>MET_CALMO (Q2QLC0) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1381 Score = 85.1 bits (209), Expect = 7e-17 Identities = 47/129 (36%), Positives = 73/129 (56%), Gaps = 5/129 (3%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLIS 220 +V Y K G +RNF+ R + + +K + L VA+GM Y+ F+HRDL + N ++ Sbjct: 1155 VVLPYMKHGDLRNFI-RNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLD 1213 Query: 221 GDKSIKIADFGVARIEVKTEGMTPETGT-----YRWMAPEMIQHRPYNQKVDVYSFGIVL 385 ++K+ADFG+AR E + T +WMA E +Q + + K DV+SFG++L Sbjct: 1214 EKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLL 1273 Query: 386 WELITGTLP 412 WEL+T P Sbjct: 1274 WELMTRGAP 1282
>MET_CALJA (Q2QLG5) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1381 Score = 85.1 bits (209), Expect = 7e-17 Identities = 47/129 (36%), Positives = 73/129 (56%), Gaps = 5/129 (3%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLIS 220 +V Y K G +RNF+ R + + +K + L VA+GM Y+ F+HRDL + N ++ Sbjct: 1155 VVLPYMKHGDLRNFI-RNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLD 1213 Query: 221 GDKSIKIADFGVARIEVKTEGMTPETGT-----YRWMAPEMIQHRPYNQKVDVYSFGIVL 385 ++K+ADFG+AR E + T +WMA E +Q + + K DV+SFG++L Sbjct: 1214 EKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLL 1273 Query: 386 WELITGTLP 412 WEL+T P Sbjct: 1274 WELMTRGAP 1282
>EPHA5_MOUSE (Q60629) Ephrin type-A receptor 5 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Brain-specific kinase) (CEK-7) Length = 877 Score = 85.1 bits (209), Expect = 7e-17 Identities = 49/136 (36%), Positives = 79/136 (58%), Gaps = 5/136 (3%) Frame = +2 Query: 23 KPIVWCIVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKS 202 KP++ IVT Y + GS+ FL + + ++L V +A GM Y+ +G++HRDL + Sbjct: 586 KPVM--IVTEYMENGSLDTFLKKNDGQFTVIQL-VGMLRGIAAGMKYLSDMGYVHRDLAA 642 Query: 203 DNLLISGDKSIKIADFGVARI-EVKTEGMTPETG---TYRWMAPEMIQHRPYNQKVDVYS 370 N+LI+ + K++DFG++R+ E E G RW APE I R + DV+S Sbjct: 643 RNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAFRKFTSASDVWS 702 Query: 371 FGIVLWELIT-GTLPF 415 +GIV+WE+++ G P+ Sbjct: 703 YGIVMWEVVSYGERPY 718
>TXK_MOUSE (P42682) Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18)| (Resting lymphocyte kinase) Length = 527 Score = 85.1 bits (209), Expect = 7e-17 Identities = 46/138 (33%), Positives = 77/138 (55%), Gaps = 3/138 (2%) Frame = +2 Query: 11 GACRKPIVWCIVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHR 190 G C + IVT + + G + ++L R+ + + L + D+ GMAY+ +IHR Sbjct: 331 GVCIQQKPLYIVTEFMENGCLLDYLRERKGQ-LQKALLLSMCQDICEGMAYLERSCYIHR 389 Query: 191 DLKSDNLLISGDKSIKIADFGVARIEVKTEGMTPETGTY--RWMAPEMIQHRPYNQKVDV 364 DL + N L+S +KI+DFG+AR + E ++ + +W PE+ Y+ K DV Sbjct: 390 DLAARNCLVSSACVVKISDFGMARYVLDDEYISSSGAKFPVKWCPPEVFHFNKYSSKSDV 449 Query: 365 YSFGIVLWELIT-GTLPF 415 +SFG+++WE+ T G +PF Sbjct: 450 WSFGVLMWEVFTEGKMPF 467
>SRC_MOUSE (P05480) Neuronal proto-oncogene tyrosine-protein kinase Src (EC| 2.7.10.2) (p60-Src) (c-Src) (pp60c-src) Length = 540 Score = 85.1 bits (209), Expect = 7e-17 Identities = 49/131 (37%), Positives = 75/131 (57%), Gaps = 4/131 (3%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLIS 220 IVT Y GS+ +FL + + L V + +A GMAYV + ++HRDL++ N+L+ Sbjct: 343 IVTEYMNKGSLLDFLKGETGKYLRLPQLVDMSAQIASGMAYVERMNYVHRDLRAANILVG 402 Query: 221 GDKSIKIADFGVARIEVKTEGMTPETGT---YRWMAPEMIQHRPYNQKVDVYSFGIVLWE 391 + K+ADFG+AR+ ++ T G +W APE + + K DV+SFGI+L E Sbjct: 403 ENLVCKVADFGLARL-IEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTE 461 Query: 392 LIT-GTLPFLG 421 L T G +P+ G Sbjct: 462 LTTKGRVPYPG 472
>PKN6_MYXXA (P54738) Serine/threonine-protein kinase pkn6 (EC 2.7.11.1)| Length = 710 Score = 85.1 bits (209), Expect = 7e-17 Identities = 46/134 (34%), Positives = 73/134 (54%), Gaps = 13/134 (9%) Frame = +2 Query: 53 YAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHG---------LGFIHRDLKSD 205 + G ++R + R ++P K A G+AY H LG IHRD+ D Sbjct: 88 FIDGPNLRKLVKRAAEEALPPAFCAKVVAAAAEGLAYAHEFRDVETGEPLGLIHRDVSPD 147 Query: 206 NLLISGDKSIKIADFGVARIEVKTEGMTPETGTYR----WMAPEMIQHRPYNQKVDVYSF 373 N+L+S ++K+ DFG+A+ V +G TG + +M PE +Q + +++VDVY+ Sbjct: 148 NILVSRQGAVKVVDFGIAK--VAGQGHRTLTGVVKGKVAYMPPEQLQAKAMDRRVDVYAL 205 Query: 374 GIVLWELITGTLPF 415 G+VL+EL+TG PF Sbjct: 206 GVVLYELLTGKRPF 219
>FGFR1_XENLA (P22182) Fibroblast growth factor receptor 1 precursor (EC 2.7.10.1)| (FGFR-1) Length = 812 Score = 84.7 bits (208), Expect = 9e-17 Identities = 55/160 (34%), Positives = 82/160 (51%), Gaps = 22/160 (13%) Frame = +2 Query: 8 VGACRKPIVWCIVTGYAKGGSVRNFLNRRQ--------------NRSVPLKLAVKQALDV 145 +GAC + ++ Y G++R +L R+ ++ + K V A V Sbjct: 542 LGACTQDGPLYVIVEYTSKGNLREYLRARRPPAMEYCYNPTCVPDQLLSFKDLVSCAYQV 601 Query: 146 ARGMAYVHGLGFIHRDLKSDNLLISGDKSIKIADFGVAR-------IEVKTEGMTPETGT 304 ARGM Y+ IHRDL + N+L++ D +KIADFG+AR + T G P Sbjct: 602 ARGMDYLASKKCIHRDLAARNVLVTEDNIMKIADFGLARDIHHIDYYKKTTNGRLP---- 657 Query: 305 YRWMAPEMIQHRPYNQKVDVYSFGIVLWELIT-GTLPFLG 421 +WMAPE + R Y + DV+SFG++LWE+ T G P+ G Sbjct: 658 VKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPG 697
>YES_MOUSE (Q04736) Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2)| (p61-Yes) (c-Yes) Length = 540 Score = 84.7 bits (208), Expect = 9e-17 Identities = 49/131 (37%), Positives = 75/131 (57%), Gaps = 4/131 (3%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLIS 220 IVT + GS+ +FL + + L V A +A GMAY+ + +IHRDL++ N+L+ Sbjct: 343 IVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVG 402 Query: 221 GDKSIKIADFGVARIEVKTEGMTPETGT---YRWMAPEMIQHRPYNQKVDVYSFGIVLWE 391 + KIADFG+AR+ ++ T G +W APE + + K DV+SFGI+ E Sbjct: 403 ENLICKIADFGLARL-IEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTE 461 Query: 392 LIT-GTLPFLG 421 L+T G +P+ G Sbjct: 462 LVTKGRVPYPG 472
>RLK5_ARATH (P47735) Receptor-like protein kinase 5 precursor (EC 2.7.11.1)| Length = 999 Score = 84.7 bits (208), Expect = 9e-17 Identities = 51/146 (34%), Positives = 79/146 (54%), Gaps = 19/146 (13%) Frame = +2 Query: 32 VWC---------IVTGYAKGGSVRNFLNRRQNRSVPLKLA--VKQALDVARGMAYVHG-- 172 +WC +V Y GS+ + L+ + V L ++ ALD A G++Y+H Sbjct: 752 LWCCCSSGDCKLLVYEYMPNGSLADVLHGDRKGGVVLGWPERLRIALDAAEGLSYLHHDC 811 Query: 173 -LGFIHRDLKSDNLLISGDKSIKIADFGVARIEVKTEGMTPET-----GTYRWMAPEMIQ 334 +HRD+KS N+L+ D K+ADFG+A++ + TPE G+ ++APE + Sbjct: 812 VPPIVHRDVKSSNILLDSDYGAKVADFGIAKVGQMSGSKTPEAMSGIAGSCGYIAPEYVY 871 Query: 335 HRPYNQKVDVYSFGIVLWELITGTLP 412 N+K D+YSFG+VL EL+TG P Sbjct: 872 TLRVNEKSDIYSFGVVLLELVTGKQP 897
>MET_RAT (P97523) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1382 Score = 84.7 bits (208), Expect = 9e-17 Identities = 47/129 (36%), Positives = 73/129 (56%), Gaps = 5/129 (3%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLIS 220 +V Y K G +RNF+ R + + +K + L VA+GM Y+ F+HRDL + N ++ Sbjct: 1156 VVLPYMKHGDLRNFI-RNETHNPTVKDLIGFGLQVAKGMKYLVSKKFVHRDLAARNCMLD 1214 Query: 221 GDKSIKIADFGVARIEVKTEGMTPETGT-----YRWMAPEMIQHRPYNQKVDVYSFGIVL 385 ++K+ADFG+AR E + T +WMA E +Q + + K DV+SFG++L Sbjct: 1215 EKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLL 1274 Query: 386 WELITGTLP 412 WEL+T P Sbjct: 1275 WELMTRGAP 1283
>FGR_FSVGR (P00544) Tyrosine-protein kinase transforming protein Fgr (EC| 2.7.10.2) Length = 545 Score = 84.7 bits (208), Expect = 9e-17 Identities = 51/131 (38%), Positives = 75/131 (57%), Gaps = 4/131 (3%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLIS 220 IVT + GS+ FL ++ + + L V A VA GMAY+ + +IHRDL++ N+L+ Sbjct: 355 IVTEFMCHGSLLEFLKDQEGQDLTLPQLVDMAAQVAEGMAYMERMDYIHRDLRAANILVG 414 Query: 221 GDKSIKIADFGVARIEVKTEGMTPETGT---YRWMAPEMIQHRPYNQKVDVYSFGIVLWE 391 KIADFG+AR+ ++ P G +W APE + K DV+SFGI+L E Sbjct: 415 ERLVCKIADFGLARL-IEDNEYNPRQGAKFPIKWTAPEAALFGRFTIKSDVWSFGILLTE 473 Query: 392 LIT-GTLPFLG 421 LI+ G +P+ G Sbjct: 474 LISKGRVPYPG 484
>EPHA7_RAT (P54759) Ephrin type-A receptor 7 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) Length = 998 Score = 84.7 bits (208), Expect = 9e-17 Identities = 48/136 (35%), Positives = 82/136 (60%), Gaps = 5/136 (3%) Frame = +2 Query: 23 KPIVWCIVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKS 202 KP++ IV + + G++ FL + + ++L V +A GM Y+ +G++HRDL + Sbjct: 705 KPVM--IVIEFMENGALDAFLRKHDGQFTVIQL-VGMLRGIAAGMRYLADMGYVHRDLAA 761 Query: 203 DNLLISGDKSIKIADFGVAR-IEVKTEGMTPETG---TYRWMAPEMIQHRPYNQKVDVYS 370 N+L++ + K++DFG++R IE E + TG RW APE IQ+R + DV+S Sbjct: 762 RNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPEAIQYRKFTSASDVWS 821 Query: 371 FGIVLWELIT-GTLPF 415 +GIV+WE+++ G P+ Sbjct: 822 YGIVMWEVMSYGERPY 837
>EPHA7_MOUSE (Q61772) Ephrin type-A receptor 7 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Embryonic brain kinase) (EBK) (Developmental kinase 1) (MDK-1) Length = 998 Score = 84.7 bits (208), Expect = 9e-17 Identities = 48/136 (35%), Positives = 82/136 (60%), Gaps = 5/136 (3%) Frame = +2 Query: 23 KPIVWCIVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKS 202 KP++ IV + + G++ FL + + ++L V +A GM Y+ +G++HRDL + Sbjct: 705 KPVM--IVIEFMENGALDAFLRKHDGQFTVIQL-VGMLRGIAAGMRYLADMGYVHRDLAA 761 Query: 203 DNLLISGDKSIKIADFGVAR-IEVKTEGMTPETG---TYRWMAPEMIQHRPYNQKVDVYS 370 N+L++ + K++DFG++R IE E + TG RW APE IQ+R + DV+S Sbjct: 762 RNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPEAIQYRKFTSASDVWS 821 Query: 371 FGIVLWELIT-GTLPF 415 +GIV+WE+++ G P+ Sbjct: 822 YGIVMWEVMSYGERPY 837
>EPHA7_HUMAN (Q15375) Ephrin type-A receptor 7 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Receptor protein-tyrosine kinase HEK11) Length = 998 Score = 84.7 bits (208), Expect = 9e-17 Identities = 48/136 (35%), Positives = 82/136 (60%), Gaps = 5/136 (3%) Frame = +2 Query: 23 KPIVWCIVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKS 202 KP++ IV + + G++ FL + + ++L V +A GM Y+ +G++HRDL + Sbjct: 705 KPVM--IVIEFMENGALDAFLRKHDGQFTVIQL-VGMLRGIAAGMRYLADMGYVHRDLAA 761 Query: 203 DNLLISGDKSIKIADFGVAR-IEVKTEGMTPETG---TYRWMAPEMIQHRPYNQKVDVYS 370 N+L++ + K++DFG++R IE E + TG RW APE IQ+R + DV+S Sbjct: 762 RNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPEAIQYRKFTSASDVWS 821 Query: 371 FGIVLWELIT-GTLPF 415 +GIV+WE+++ G P+ Sbjct: 822 YGIVMWEVMSYGERPY 837
>FGFR1_RAT (Q04589) Basic fibroblast growth factor receptor 1 precursor (EC| 2.7.10.1) (FGFR-1) (bFGF-R) (MFR) Length = 822 Score = 84.7 bits (208), Expect = 9e-17 Identities = 53/152 (34%), Positives = 77/152 (50%), Gaps = 21/152 (13%) Frame = +2 Query: 8 VGACRKPIVWCIVTGYAKGGSVRNFLNRRQ--------------NRSVPLKLAVKQALDV 145 +GAC + ++ YA G++R +L R+ + K V A V Sbjct: 548 LGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQV 607 Query: 146 ARGMAYVHGLGFIHRDLKSDNLLISGDKSIKIADFGVAR-------IEVKTEGMTPETGT 304 ARGM Y+ IHRDL + N+L++ D +KIADFG+AR + T G P Sbjct: 608 ARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLP---- 663 Query: 305 YRWMAPEMIQHRPYNQKVDVYSFGIVLWELIT 400 +WMAPE + R Y + DV+SFG++LWE+ T Sbjct: 664 VKWMAPEALFDRIYTHQSDVWSFGVLLWEIFT 695
>YES_HUMAN (P07947) Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2)| (p61-Yes) (c-Yes) Length = 542 Score = 84.7 bits (208), Expect = 9e-17 Identities = 49/131 (37%), Positives = 75/131 (57%), Gaps = 4/131 (3%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLIS 220 IVT + GS+ +FL + + L V A +A GMAY+ + +IHRDL++ N+L+ Sbjct: 345 IVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVG 404 Query: 221 GDKSIKIADFGVARIEVKTEGMTPETGT---YRWMAPEMIQHRPYNQKVDVYSFGIVLWE 391 + KIADFG+AR+ ++ T G +W APE + + K DV+SFGI+ E Sbjct: 405 ENLVCKIADFGLARL-IEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTE 463 Query: 392 LIT-GTLPFLG 421 L+T G +P+ G Sbjct: 464 LVTKGRVPYPG 474
>SRC_RAT (Q9WUD9) Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2)| (p60-Src) (c-Src) (pp60c-src) Length = 535 Score = 84.7 bits (208), Expect = 9e-17 Identities = 49/131 (37%), Positives = 75/131 (57%), Gaps = 4/131 (3%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLIS 220 IVT Y GS+ +FL + + L V + +A GMAYV + ++HRDL++ N+L+ Sbjct: 338 IVTEYMNKGSLLDFLKGETGKYLRLPQLVDMSAQIASGMAYVDRMNYVHRDLRAANILVG 397 Query: 221 GDKSIKIADFGVARIEVKTEGMTPETGT---YRWMAPEMIQHRPYNQKVDVYSFGIVLWE 391 + K+ADFG+AR+ ++ T G +W APE + + K DV+SFGI+L E Sbjct: 398 ENLVCKVADFGLARL-IEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTE 456 Query: 392 LIT-GTLPFLG 421 L T G +P+ G Sbjct: 457 LTTKGRVPYPG 467
>TEC_MOUSE (P24604) Tyrosine-protein kinase Tec (EC 2.7.10.2)| Length = 630 Score = 84.7 bits (208), Expect = 9e-17 Identities = 51/141 (36%), Positives = 79/141 (56%), Gaps = 6/141 (4%) Frame = +2 Query: 11 GAC--RKPIVWCIVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFI 184 G C +KPI IVT + + G + NFL +RQ + + DV GM Y+ FI Sbjct: 429 GVCTQQKPIY--IVTEFMERGCLLNFLRQRQGH-FSRDMLLSMCQDVCEGMEYLERNSFI 485 Query: 185 HRDLKSDNLLISGDKSIKIADFGVARIEVKTEGMTPETGT---YRWMAPEMIQHRPYNQK 355 HRDL + N L++ +K++DFG+AR V + T +G +W PE+ + ++ K Sbjct: 486 HRDLAARNCLVNEAGVVKVSDFGMARY-VLDDQYTSSSGAKFPVKWCPPEVFNYSRFSSK 544 Query: 356 VDVYSFGIVLWELIT-GTLPF 415 DV+SFG+++WE+ T G +PF Sbjct: 545 SDVWSFGVLMWEIFTEGRMPF 565
>EPHA6_RAT (P54758) Ephrin type-A receptor 6 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2) Length = 1035 Score = 84.7 bits (208), Expect = 9e-17 Identities = 46/130 (35%), Positives = 77/130 (59%), Gaps = 5/130 (3%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLIS 220 IV Y + GS+ +FL + ++L V +A GM Y+ +G++HRDL + N+L++ Sbjct: 748 IVVEYMENGSLDSFLRKHDGHFTVIQL-VGMLRGIASGMKYLSDMGYVHRDLAARNILVN 806 Query: 221 GDKSIKIADFGVARI-EVKTEGMTPETG---TYRWMAPEMIQHRPYNQKVDVYSFGIVLW 388 + K++DFG++R+ E E TG RW APE I +R ++ DV+S+GIV+W Sbjct: 807 SNLVCKVSDFGLSRVLEDDPEAAYTTTGGKIPIRWTAPEAIAYRKFSSASDVWSYGIVMW 866 Query: 389 ELIT-GTLPF 415 E+++ G P+ Sbjct: 867 EVMSYGERPY 876
>SRC_RSVSE (P63185) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 84.7 bits (208), Expect = 9e-17 Identities = 50/135 (37%), Positives = 75/135 (55%), Gaps = 4/135 (2%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLIS 220 IV Y GS+ +FL + + L V A +A GMAYV + ++HRDL++ N+L+ Sbjct: 335 IVIEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVG 394 Query: 221 GDKSIKIADFGVARIEVKTEGMTPETGT---YRWMAPEMIQHRPYNQKVDVYSFGIVLWE 391 + K+ADFG+AR+ ++ T G +W APE + + K DV+SFGI+L E Sbjct: 395 ENLVCKVADFGLARL-IEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTE 453 Query: 392 LIT-GTLPFLGGRGG 433 L T G +P+ G G Sbjct: 454 LTTKGRVPYPGMGNG 468
>EPHA3_HUMAN (P29320) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ETK1) (HEK) (HEK4) Length = 983 Score = 84.7 bits (208), Expect = 9e-17 Identities = 49/136 (36%), Positives = 81/136 (59%), Gaps = 5/136 (3%) Frame = +2 Query: 23 KPIVWCIVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKS 202 KP++ IVT Y + GS+ +FL + + ++L V +A GM Y+ +G++HRDL + Sbjct: 693 KPVM--IVTEYMENGSLDSFLRKHDAQFTVIQL-VGMLRGIASGMKYLSDMGYVHRDLAA 749 Query: 203 DNLLISGDKSIKIADFGVARI-EVKTEGMTPETG---TYRWMAPEMIQHRPYNQKVDVYS 370 N+LI+ + K++DFG++R+ E E G RW +PE I +R + DV+S Sbjct: 750 RNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTSPEAIAYRKFTSASDVWS 809 Query: 371 FGIVLWELIT-GTLPF 415 +GIVLWE+++ G P+ Sbjct: 810 YGIVLWEVMSYGERPY 825
>SRK4_SPOLA (P42690) Tyrosine-protein kinase isoform SRK4 (EC 2.7.10.2)| Length = 506 Score = 84.3 bits (207), Expect = 1e-16 Identities = 55/138 (39%), Positives = 74/138 (53%), Gaps = 3/138 (2%) Frame = +2 Query: 17 CRKPIVWCIVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDL 196 C K IVT K GS+ +L R RS+ L V VA GM+Y+ +IHRDL Sbjct: 302 CTKEEPIYIVTELMKHGSLLEYL-RGDGRSLKLPDLVDMCSQVASGMSYLEQQNYIHRDL 360 Query: 197 KSDNLLISGDKSIKIADFGVARI--EVKTEGMTPETGTYRWMAPEMIQHRPYNQKVDVYS 370 + N+L+ K K+ADFG+AR+ E E +W APE + + K DV+S Sbjct: 361 AARNILVGEHKICKVADFGLARVIDEEIYEAKLGAKFPIKWTAPEAAMYSRFTIKSDVWS 420 Query: 371 FGIVLWELIT-GTLPFLG 421 FGIVL+E+IT G P+ G Sbjct: 421 FGIVLYEVITYGRFPYPG 438
>KCC4_YEAST (P25389) Probable serine/threonine-protein kinase KCC4 (EC| 2.7.11.1) Length = 1037 Score = 84.3 bits (207), Expect = 1e-16 Identities = 45/126 (35%), Positives = 74/126 (58%), Gaps = 1/126 (0%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLIS 220 ++ YA+ G + N L + +P + A+ + G++Y H LG +HRDLK +NLL+ Sbjct: 104 LILEYAEKGELFNLLV--DHGPLPEREAINCFRQIIIGISYCHALGIVHRDLKPENLLLD 161 Query: 221 GDKSIKIADFGVARIEVKTEGMTPETGTYRWMAPEMIQHRPYNQ-KVDVYSFGIVLWELI 397 +IKIADFG+A ++ + + G+ + APE++ PY DV+S G++L+ L+ Sbjct: 162 SFYNIKIADFGMAALQTDADLLETSCGSPHYAAPEIVSGLPYEGFASDVWSCGVILFALL 221 Query: 398 TGTLPF 415 TG LPF Sbjct: 222 TGRLPF 227
>PAK7_MOUSE (Q8C015) Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1)| (p21-activated kinase 7) (PAK-7) (p21-activated kinase 5) Length = 719 Score = 84.3 bits (207), Expect = 1e-16 Identities = 42/126 (33%), Positives = 73/126 (57%), Gaps = 1/126 (0%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLIS 220 +V + +GG++ + + + + L V + ++Y+H G IHRD+KSD++L++ Sbjct: 521 VVMEFLEGGALTDIVTHTRMNEEQIATV---CLSVLKALSYLHNQGVIHRDIKSDSILLT 577 Query: 221 GDKSIKIADFG-VARIEVKTEGMTPETGTYRWMAPEMIQHRPYNQKVDVYSFGIVLWELI 397 D IK++DFG A++ + GT WMAPE+I PY +VD++S GI++ E+I Sbjct: 578 SDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMI 637 Query: 398 TGTLPF 415 G P+ Sbjct: 638 DGEPPY 643
>EPHA5_CHICK (P54755) Ephrin type-A receptor 5 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor CEK7) Length = 1013 Score = 84.3 bits (207), Expect = 1e-16 Identities = 49/136 (36%), Positives = 79/136 (58%), Gaps = 5/136 (3%) Frame = +2 Query: 23 KPIVWCIVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKS 202 KP++ IVT Y + GS+ FL + + ++L V +A GM Y+ +G++HRDL + Sbjct: 723 KPVM--IVTEYMENGSLDTFLKKNDGQFTVIQL-VGMLRGIASGMKYLSDMGYVHRDLAA 779 Query: 203 DNLLISGDKSIKIADFGVARI-EVKTEGMTPETG---TYRWMAPEMIQHRPYNQKVDVYS 370 N+LI+ + K++DFG++R+ E E G RW APE I R + DV+S Sbjct: 780 RNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAFRKFTSASDVWS 839 Query: 371 FGIVLWELIT-GTLPF 415 +GIV+WE+++ G P+ Sbjct: 840 YGIVMWEVMSYGERPY 855
>SRC_RSVP (P00526) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 84.3 bits (207), Expect = 1e-16 Identities = 49/131 (37%), Positives = 74/131 (56%), Gaps = 4/131 (3%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLIS 220 IV Y GS+ +FL + + L V A +A GMAYV + ++HRDL++ N+L+ Sbjct: 335 IVIEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVG 394 Query: 221 GDKSIKIADFGVARIEVKTEGMTPETGT---YRWMAPEMIQHRPYNQKVDVYSFGIVLWE 391 + K+ADFG+AR+ ++ T G +W APE + + K DV+SFGI+L E Sbjct: 395 ENLVCKVADFGLARL-IEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTE 453 Query: 392 LIT-GTLPFLG 421 L T G +P+ G Sbjct: 454 LTTKGRVPYPG 464
>SRC_RSVH1 (P25020) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 84.3 bits (207), Expect = 1e-16 Identities = 49/131 (37%), Positives = 74/131 (56%), Gaps = 4/131 (3%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLIS 220 IV Y GS+ +FL + + L V A +A GMAYV + ++HRDL++ N+L+ Sbjct: 335 IVIEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVG 394 Query: 221 GDKSIKIADFGVARIEVKTEGMTPETGT---YRWMAPEMIQHRPYNQKVDVYSFGIVLWE 391 + K+ADFG+AR+ ++ T G +W APE + + K DV+SFGI+L E Sbjct: 395 ENLVCKVADFGLARL-IEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTE 453 Query: 392 LIT-GTLPFLG 421 L T G +P+ G Sbjct: 454 LTTKGRVPYPG 464
>TEC_HUMAN (P42680) Tyrosine-protein kinase Tec (EC 2.7.10.2)| Length = 631 Score = 84.0 bits (206), Expect = 1e-16 Identities = 51/141 (36%), Positives = 79/141 (56%), Gaps = 6/141 (4%) Frame = +2 Query: 11 GAC--RKPIVWCIVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFI 184 G C +KPI IVT + + G + NFL +RQ + + DV GM Y+ FI Sbjct: 430 GVCTQQKPIY--IVTEFMERGCLLNFLRQRQGH-FSRDVLLSMCQDVCEGMEYLERNSFI 486 Query: 185 HRDLKSDNLLISGDKSIKIADFGVARIEVKTEGMTPETGT---YRWMAPEMIQHRPYNQK 355 HRDL + N L+S +K++DFG+AR + + T +G +W PE+ + ++ K Sbjct: 487 HRDLAARNCLVSEAGVVKVSDFGMARYFLDDQ-YTSSSGAKFPVKWCPPEVFNYSRFSSK 545 Query: 356 VDVYSFGIVLWELIT-GTLPF 415 DV+SFG+++WE+ T G +PF Sbjct: 546 SDVWSFGVLMWEVFTEGRMPF 566
>KPCB_RAT (P68403) Protein kinase C beta type (EC 2.7.11.13) (PKC-beta)| (PKC-B) Length = 670 Score = 84.0 bits (206), Expect = 1e-16 Identities = 46/128 (35%), Positives = 78/128 (60%), Gaps = 2/128 (1%) Frame = +2 Query: 44 VTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLISG 223 V Y GG + + + P AV A ++A G+ ++ G I+RDLK DN+++ Sbjct: 418 VMEYVNGGDLMYHIQQVGRFKEPH--AVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDS 475 Query: 224 DKSIKIADFGVARIEVKTEGMTPET--GTYRWMAPEMIQHRPYNQKVDVYSFGIVLWELI 397 + IKIADFG+ + + +G+T +T GT ++APE+I ++PY + VD ++FG++L+E++ Sbjct: 476 EGHIKIADFGMCKENI-WDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEML 534 Query: 398 TGTLPFLG 421 G PF G Sbjct: 535 AGQAPFEG 542
>KPCB_RABIT (P05772) Protein kinase C beta type (EC 2.7.11.13) (PKC-beta)| (PKC-B) Length = 670 Score = 84.0 bits (206), Expect = 1e-16 Identities = 46/128 (35%), Positives = 78/128 (60%), Gaps = 2/128 (1%) Frame = +2 Query: 44 VTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLISG 223 V Y GG + + + P AV A ++A G+ ++ G I+RDLK DN+++ Sbjct: 418 VMEYVNGGDLMYHIQQVGRFKEPH--AVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDS 475 Query: 224 DKSIKIADFGVARIEVKTEGMTPET--GTYRWMAPEMIQHRPYNQKVDVYSFGIVLWELI 397 + IKIADFG+ + + +G+T +T GT ++APE+I ++PY + VD ++FG++L+E++ Sbjct: 476 EGHIKIADFGMCKENI-WDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEML 534 Query: 398 TGTLPFLG 421 G PF G Sbjct: 535 AGQAPFEG 542
>KPCB_HUMAN (P05771) Protein kinase C beta type (EC 2.7.11.13) (PKC-beta)| (PKC-B) Length = 670 Score = 84.0 bits (206), Expect = 1e-16 Identities = 46/128 (35%), Positives = 78/128 (60%), Gaps = 2/128 (1%) Frame = +2 Query: 44 VTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLISG 223 V Y GG + + + P AV A ++A G+ ++ G I+RDLK DN+++ Sbjct: 418 VMEYVNGGDLMYHIQQVGRFKEPH--AVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDS 475 Query: 224 DKSIKIADFGVARIEVKTEGMTPET--GTYRWMAPEMIQHRPYNQKVDVYSFGIVLWELI 397 + IKIADFG+ + + +G+T +T GT ++APE+I ++PY + VD ++FG++L+E++ Sbjct: 476 EGHIKIADFGMCKENI-WDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEML 534 Query: 398 TGTLPFLG 421 G PF G Sbjct: 535 AGQAPFEG 542
>EPHA2_HUMAN (P29317) Ephrin type-A receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) Length = 976 Score = 84.0 bits (206), Expect = 1e-16 Identities = 48/136 (35%), Positives = 79/136 (58%), Gaps = 5/136 (3%) Frame = +2 Query: 23 KPIVWCIVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKS 202 KP++ I+T Y + G++ FL + L+L V +A GM Y+ + ++HRDL + Sbjct: 686 KPMM--IITEYMENGALDKFLREKDGEFSVLQL-VGMLRGIAAGMKYLANMNYVHRDLAA 742 Query: 203 DNLLISGDKSIKIADFGVARI-EVKTEGMTPETG---TYRWMAPEMIQHRPYNQKVDVYS 370 N+L++ + K++DFG++R+ E E +G RW APE I +R + DV+S Sbjct: 743 RNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPEAISYRKFTSASDVWS 802 Query: 371 FGIVLWELIT-GTLPF 415 FGIV+WE++T G P+ Sbjct: 803 FGIVMWEVMTYGERPY 818
>KPC2_DROME (P13677) Protein kinase C, eye isozyme (EC 2.7.11.13) (PKC)| (dPKC53E(EY)) (Protein INAC) (Inactivation no after-potential C protein) (Photoreceptor-specific PKC) (Eye-PKC) Length = 700 Score = 84.0 bits (206), Expect = 1e-16 Identities = 47/128 (36%), Positives = 76/128 (59%), Gaps = 2/128 (1%) Frame = +2 Query: 44 VTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLISG 223 V Y KGG + + +Q +A+ A++VA + ++H I+RDLK DN+L+ G Sbjct: 448 VMEYCKGGDL--MYHMQQYGRFKESVAIFYAVEVAIALFFLHERDIIYRDLKLDNILLDG 505 Query: 224 DKSIKIADFGVARIEVKTEGMTPET--GTYRWMAPEMIQHRPYNQKVDVYSFGIVLWELI 397 + +K+ DFG+++ E TE T T GT +MAPE++ + PY+ D +SFG++L+E + Sbjct: 506 EGHVKLVDFGLSK-EGVTERQTTRTFCGTPNYMAPEIVSYDPYSIAADWWSFGVLLFEFM 564 Query: 398 TGTLPFLG 421 G PF G Sbjct: 565 AGQAPFEG 572
>KPCB_MOUSE (P68404) Protein kinase C beta type (EC 2.7.11.13) (PKC-beta)| (PKC-B) Length = 672 Score = 84.0 bits (206), Expect = 1e-16 Identities = 46/128 (35%), Positives = 78/128 (60%), Gaps = 2/128 (1%) Frame = +2 Query: 44 VTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLISG 223 V Y GG + + + P AV A ++A G+ ++ G I+RDLK DN+++ Sbjct: 418 VMEYVNGGDLMYHIQQVGRFKEPH--AVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDS 475 Query: 224 DKSIKIADFGVARIEVKTEGMTPET--GTYRWMAPEMIQHRPYNQKVDVYSFGIVLWELI 397 + IKIADFG+ + + +G+T +T GT ++APE+I ++PY + VD ++FG++L+E++ Sbjct: 476 EGHIKIADFGMCKENI-WDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEML 534 Query: 398 TGTLPFLG 421 G PF G Sbjct: 535 AGQAPFEG 542
>KPCB_BOVIN (P05126) Protein kinase C beta type (EC 2.7.11.13) (PKC-beta)| (PKC-B) Length = 672 Score = 84.0 bits (206), Expect = 1e-16 Identities = 46/128 (35%), Positives = 78/128 (60%), Gaps = 2/128 (1%) Frame = +2 Query: 44 VTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLISG 223 V Y GG + + + P AV A ++A G+ ++ G I+RDLK DN+++ Sbjct: 418 VMEYVNGGDLMYHIQQVGRFKEPH--AVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDS 475 Query: 224 DKSIKIADFGVARIEVKTEGMTPET--GTYRWMAPEMIQHRPYNQKVDVYSFGIVLWELI 397 + IKIADFG+ + + +G+T +T GT ++APE+I ++PY + VD ++FG++L+E++ Sbjct: 476 EGHIKIADFGMCKENI-WDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEML 534 Query: 398 TGTLPFLG 421 G PF G Sbjct: 535 AGQAPFEG 542
>FGFR4_RAT (Q498D6) Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1)| (FGFR-4) Length = 800 Score = 84.0 bits (206), Expect = 1e-16 Identities = 57/160 (35%), Positives = 81/160 (50%), Gaps = 22/160 (13%) Frame = +2 Query: 8 VGACRKPIVWCIVTGYAKGGSVRNFLNRRQ------------NRSVPLKLA--VKQALDV 145 +G C + ++ YA G++R FL R+ + PL V A V Sbjct: 535 LGVCTQEGPLYVIVEYAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPALVSCAYQV 594 Query: 146 ARGMAYVHGLGFIHRDLKSDNLLISGDKSIKIADFGVAR-------IEVKTEGMTPETGT 304 ARGM Y+ IHRDL + N+L++ D +KIADFG+AR + + G P Sbjct: 595 ARGMQYLESRKCIHRDLAARNVLVTEDDVMKIADFGLARGVHHIDYYKKTSNGRLP---- 650 Query: 305 YRWMAPEMIQHRPYNQKVDVYSFGIVLWELIT-GTLPFLG 421 +WMAPE + R Y + DV+SFGI+LWE+ T G P+ G Sbjct: 651 VKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPG 690
>TXK_HUMAN (P42681) Tyrosine-protein kinase TXK (EC 2.7.10.2)| Length = 527 Score = 84.0 bits (206), Expect = 1e-16 Identities = 47/140 (33%), Positives = 79/140 (56%), Gaps = 5/140 (3%) Frame = +2 Query: 11 GAC--RKPIVWCIVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFI 184 G C RKP+ IVT + + G + N+L + + + ++ + D+ GM Y+ G+I Sbjct: 331 GVCIQRKPLY--IVTEFMENGCLLNYLRENKGK-LRKEMLLSVCQDICEGMEYLERNGYI 387 Query: 185 HRDLKSDNLLISGDKSIKIADFGVARIEVKTEGMTPETGTY--RWMAPEMIQHRPYNQKV 358 HRDL + N L+S +KI+DFG+ R + E ++ + +W PE+ Y+ K Sbjct: 388 HRDLAARNCLVSSTCIVKISDFGMTRYVLDDEYVSSFGAKFPIKWSPPEVFLFNKYSSKS 447 Query: 359 DVYSFGIVLWELIT-GTLPF 415 DV+SFG+++WE+ T G +PF Sbjct: 448 DVWSFGVLMWEVFTEGKMPF 467
>STE20_YEAST (Q03497) Serine/threonine-protein kinase STE20 (EC 2.7.11.1)| Length = 939 Score = 84.0 bits (206), Expect = 1e-16 Identities = 44/127 (34%), Positives = 72/127 (56%), Gaps = 1/127 (0%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLIS 220 ++ Y +GGS+ + + + ++ L G+ ++H G +HRD+KSDN+L+S Sbjct: 692 VIMEYMEGGSLTDVVTHCILTEGQIGAVCRETLS---GLEFLHSKGVLHRDIKSDNILLS 748 Query: 221 GDKSIKIADFGV-ARIEVKTEGMTPETGTYRWMAPEMIQHRPYNQKVDVYSFGIVLWELI 397 + IK+ DFG A+I T GT WMAPE++ + Y KVD++S GI++ E+I Sbjct: 749 MEGDIKLTDFGFCAQINELNLKRTTMVGTPYWMAPEVVSRKEYGPKVDIWSLGIMIIEMI 808 Query: 398 TGTLPFL 418 G P+L Sbjct: 809 EGEPPYL 815
>EPHA5_HUMAN (P54756) Ephrin type-A receptor 5 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Receptor protein-tyrosine kinase HEK7) Length = 1037 Score = 84.0 bits (206), Expect = 1e-16 Identities = 48/136 (35%), Positives = 79/136 (58%), Gaps = 5/136 (3%) Frame = +2 Query: 23 KPIVWCIVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKS 202 KP++ IVT Y + GS+ FL + + ++L V ++ GM Y+ +G++HRDL + Sbjct: 747 KPVM--IVTEYMENGSLDTFLKKNDGQFTVIQL-VGMLRGISAGMKYLSDMGYVHRDLAA 803 Query: 203 DNLLISGDKSIKIADFGVARI-EVKTEGMTPETG---TYRWMAPEMIQHRPYNQKVDVYS 370 N+LI+ + K++DFG++R+ E E G RW APE I R + DV+S Sbjct: 804 RNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAFRKFTSASDVWS 863 Query: 371 FGIVLWELIT-GTLPF 415 +GIV+WE+++ G P+ Sbjct: 864 YGIVMWEVVSYGERPY 879
>PAK1_CAEEL (Q17850) Serine/threonine-protein kinase pak-1 (EC 2.7.11.1)| (p21-activated kinase 1) (PAK1) (CePAK) Length = 572 Score = 83.6 bits (205), Expect = 2e-16 Identities = 44/127 (34%), Positives = 71/127 (55%), Gaps = 1/127 (0%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLIS 220 +V Y GGS+ + + Q + ++ L + + ++H IHRD+KSDN+L+ Sbjct: 367 VVMEYLAGGSLTDVVTECQMEDGIIAAVCREVL---QALEFLHSRHVIHRDIKSDNILLG 423 Query: 221 GDKSIKIADFGV-ARIEVKTEGMTPETGTYRWMAPEMIQHRPYNQKVDVYSFGIVLWELI 397 D S+K+ DFG A++ + T GT WMAPE++ + Y KVDV+S GI+ E++ Sbjct: 424 MDGSVKLTDFGFCAQLSPEQRKRTTMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMAIEMV 483 Query: 398 TGTLPFL 418 G P+L Sbjct: 484 EGEPPYL 490
>FGFR2_DROME (Q09147) Fibroblast growth factor receptor homolog 2 precursor (EC| 2.7.10.1) (Protein breathless) (dFGF-R1) Length = 1052 Score = 83.6 bits (205), Expect = 2e-16 Identities = 56/161 (34%), Positives = 84/161 (52%), Gaps = 25/161 (15%) Frame = +2 Query: 8 VGACRKPIVWCIVTGYAKGGSVRNFLNRR-----QNRS--------VPL--------KLA 124 +G C + ++ YA G++++FL + Q RS PL K Sbjct: 782 LGCCSQGGPLWVIVEYAPHGNLKDFLKQNRPGAPQRRSDSDGYLDDKPLISTQHLGEKEL 841 Query: 125 VKQALDVARGMAYVHGLGFIHRDLKSDNLLISGDKSIKIADFGVARIEVKTEGMTPETG- 301 K A +ARGM Y+ IHRDL + N+L+S +KIADFG+AR TE T Sbjct: 842 TKFAFQIARGMEYLASRRCIHRDLAARNVLVSDGYVMKIADFGLARDIQDTEYYRKNTNG 901 Query: 302 --TYRWMAPEMIQHRPYNQKVDVYSFGIVLWELIT-GTLPF 415 +WMAPE +Q + Y+ + DV+S+G++LWE++T G P+ Sbjct: 902 RLPIKWMAPESLQEKKYDSQSDVWSYGVLLWEIMTYGDQPY 942
>ITK_MOUSE (Q03526) Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2)| (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK) Length = 625 Score = 83.6 bits (205), Expect = 2e-16 Identities = 47/139 (33%), Positives = 77/139 (55%), Gaps = 4/139 (2%) Frame = +2 Query: 11 GACRKPIVWCIVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHR 190 G C + C+V + + G + ++L R Q + + LDV GMAY+ IHR Sbjct: 428 GVCLEQAPICLVFEFMEHGCLSDYL-RSQRGLFAAETLLGMCLDVCEGMAYLEKACVIHR 486 Query: 191 DLKSDNLLISGDKSIKIADFGVARIEVKTEGMTPETGT---YRWMAPEMIQHRPYNQKVD 361 DL + N L+ ++ IK++DFG+ R V + T TGT +W +PE+ Y+ K D Sbjct: 487 DLAARNCLVGENQVIKVSDFGMTRF-VLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSD 545 Query: 362 VYSFGIVLWELIT-GTLPF 415 V+SFG+++WE+ + G +P+ Sbjct: 546 VWSFGVLMWEVFSEGKIPY 564
>PKN2_CLOAB (Q97IC2) Probable serine/threonine protein kinase CAC1728 (EC| 2.7.11.1) Length = 657 Score = 83.6 bits (205), Expect = 2e-16 Identities = 39/127 (30%), Positives = 73/127 (57%), Gaps = 2/127 (1%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLIS 220 IV Y G +++ + ++N + + A +A+ + + H G +HRD+K N++++ Sbjct: 85 IVMEYVAGKTLKKLI--KENGKIEFNKIIDYATQIAKALNFAHKNGIVHRDIKPHNIMVT 142 Query: 221 GDKSIKIADFGVARIEVKTEGMTPE--TGTYRWMAPEMIQHRPYNQKVDVYSFGIVLWEL 394 D IK+ DFG+A+ ++ T G+ +++PE Q P + + D+YSFGIVL+E+ Sbjct: 143 DDDIIKVTDFGIAKASNESTITTTNKVVGSAHYLSPEQAQGIPVDCRTDIYSFGIVLYEM 202 Query: 395 ITGTLPF 415 TG +P+ Sbjct: 203 ATGKVPY 209
>KPCA_RAT (P05696) Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha)| (PKC-A) Length = 671 Score = 83.6 bits (205), Expect = 2e-16 Identities = 46/128 (35%), Positives = 78/128 (60%), Gaps = 2/128 (1%) Frame = +2 Query: 44 VTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLISG 223 V Y GG + + + P AV A +++ G+ ++H G I+RDLK DN+++ Sbjct: 415 VMEYVNGGDLMYHIQQVGKFKEPQ--AVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDS 472 Query: 224 DKSIKIADFGVARIEVKTEGMTPET--GTYRWMAPEMIQHRPYNQKVDVYSFGIVLWELI 397 + IKIADFG+ + E +G+T T GT ++APE+I ++PY + VD +++G++L+E++ Sbjct: 473 EGHIKIADFGMCK-EHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEML 531 Query: 398 TGTLPFLG 421 G PF G Sbjct: 532 AGQPPFDG 539
>KPCA_RABIT (P10102) Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha)| (PKC-A) Length = 671 Score = 83.6 bits (205), Expect = 2e-16 Identities = 46/128 (35%), Positives = 78/128 (60%), Gaps = 2/128 (1%) Frame = +2 Query: 44 VTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLISG 223 V Y GG + + + P AV A +++ G+ ++H G I+RDLK DN+++ Sbjct: 415 VMEYVNGGDLMYHIQQVGKFKEPQ--AVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDS 472 Query: 224 DKSIKIADFGVARIEVKTEGMTPET--GTYRWMAPEMIQHRPYNQKVDVYSFGIVLWELI 397 + IKIADFG+ + E +G+T T GT ++APE+I ++PY + VD +++G++L+E++ Sbjct: 473 EGHIKIADFGMCK-EHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEML 531 Query: 398 TGTLPFLG 421 G PF G Sbjct: 532 AGQPPFDG 539
>KPCA_HUMAN (P17252) Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha)| (PKC-A) Length = 671 Score = 83.6 bits (205), Expect = 2e-16 Identities = 46/128 (35%), Positives = 78/128 (60%), Gaps = 2/128 (1%) Frame = +2 Query: 44 VTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLISG 223 V Y GG + + + P AV A +++ G+ ++H G I+RDLK DN+++ Sbjct: 415 VMEYVNGGDLMYHIQQVGKFKEPQ--AVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDS 472 Query: 224 DKSIKIADFGVARIEVKTEGMTPET--GTYRWMAPEMIQHRPYNQKVDVYSFGIVLWELI 397 + IKIADFG+ + E +G+T T GT ++APE+I ++PY + VD +++G++L+E++ Sbjct: 473 EGHIKIADFGMCK-EHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEML 531 Query: 398 TGTLPFLG 421 G PF G Sbjct: 532 AGQPPFDG 539
>KPCA_BOVIN (P04409) Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha)| (PKC-A) Length = 671 Score = 83.6 bits (205), Expect = 2e-16 Identities = 46/128 (35%), Positives = 78/128 (60%), Gaps = 2/128 (1%) Frame = +2 Query: 44 VTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLISG 223 V Y GG + + + P AV A +++ G+ ++H G I+RDLK DN+++ Sbjct: 415 VMEYVNGGDLMYHIQQVGKFKEPQ--AVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDS 472 Query: 224 DKSIKIADFGVARIEVKTEGMTPET--GTYRWMAPEMIQHRPYNQKVDVYSFGIVLWELI 397 + IKIADFG+ + E +G+T T GT ++APE+I ++PY + VD +++G++L+E++ Sbjct: 473 EGHIKIADFGMCK-EHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEML 531 Query: 398 TGTLPFLG 421 G PF G Sbjct: 532 AGQPPFDG 539
>EPHB5_CHICK (Q07497) Ephrin type-B receptor 5 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase CEK9) Length = 1002 Score = 83.6 bits (205), Expect = 2e-16 Identities = 44/132 (33%), Positives = 77/132 (58%), Gaps = 7/132 (5%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLIS 220 IVT + + GS+ +FL +++ + L+L V +A GM Y+ + ++HRDL + N+L++ Sbjct: 713 IVTEFMENGSLDSFLRQKEGQFSVLQL-VGMLRGIAAGMRYLSDMNYVHRDLAARNILVN 771 Query: 221 GDKSIKIADFGVARIEVKTEGMTPETGTY------RWMAPEMIQHRPYNQKVDVYSFGIV 382 + K++DFG++R TG RW APE +Q+R + DV+S+GIV Sbjct: 772 SNLVCKVSDFGLSRFLEDDASNPTYTGALGCKIPIRWTAPEAVQYRKFTSSSDVWSYGIV 831 Query: 383 LWELIT-GTLPF 415 +WE+++ G P+ Sbjct: 832 MWEVMSYGERPY 843
>ITK_HUMAN (Q08881) Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2)| (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT) Length = 620 Score = 83.6 bits (205), Expect = 2e-16 Identities = 47/139 (33%), Positives = 77/139 (55%), Gaps = 4/139 (2%) Frame = +2 Query: 11 GACRKPIVWCIVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHR 190 G C + C+V + + G + ++L R Q + + LDV GMAY+ IHR Sbjct: 423 GVCLEQAPICLVFEFMEHGCLSDYL-RTQRGLFAAETLLGMCLDVCEGMAYLEEACVIHR 481 Query: 191 DLKSDNLLISGDKSIKIADFGVARIEVKTEGMTPETGT---YRWMAPEMIQHRPYNQKVD 361 DL + N L+ ++ IK++DFG+ R V + T TGT +W +PE+ Y+ K D Sbjct: 482 DLAARNCLVGENQVIKVSDFGMTRF-VLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSD 540 Query: 362 VYSFGIVLWELIT-GTLPF 415 V+SFG+++WE+ + G +P+ Sbjct: 541 VWSFGVLMWEVFSEGKIPY 559
>KPC1_DROME (P05130) Protein kinase C, brain isozyme (EC 2.7.11.13) (PKC)| (dPKC53E(BR)) Length = 679 Score = 83.2 bits (204), Expect = 3e-16 Identities = 44/127 (34%), Positives = 76/127 (59%), Gaps = 1/127 (0%) Frame = +2 Query: 44 VTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLISG 223 V Y GG + + + P+ AV A ++A G+ ++H G ++RDLK DN+L+ Sbjct: 427 VMEYVNGGDLMFQIQQFGKFKEPV--AVFYAAEIAAGLFFLHTKGILYRDLKLDNVLLDA 484 Query: 224 DKSIKIADFGVARIEVKTEGMTPE-TGTYRWMAPEMIQHRPYNQKVDVYSFGIVLWELIT 400 D +KIADFG+ + + + T GT ++APE+I ++PY + VD +++G++L+E++ Sbjct: 485 DGHVKIADFGMCKENIVGDKTTKTFCGTPDYIAPEIILYQPYGKSVDWWAYGVLLYEMLV 544 Query: 401 GTLPFLG 421 G PF G Sbjct: 545 GQPPFDG 551
>YES_CANFA (Q28923) Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2)| (p61-Yes) (c-Yes) Length = 538 Score = 83.2 bits (204), Expect = 3e-16 Identities = 49/131 (37%), Positives = 74/131 (56%), Gaps = 4/131 (3%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLIS 220 IVT + GS+ +FL + + L V A +A GMAY+ + +IHRDL++ N+L+ Sbjct: 341 IVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVG 400 Query: 221 GDKSIKIADFGVARIEVKTEGMTPETGT---YRWMAPEMIQHRPYNQKVDVYSFGIVLWE 391 + KIADFG+AR+ ++ T G +W APE + + K DV+SFGI+ E Sbjct: 401 ENLVCKIADFGLARL-IEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTE 459 Query: 392 LIT-GTLPFLG 421 L T G +P+ G Sbjct: 460 LTTKGRVPYPG 470
>EPHA8_RAT (P29321) Ephrin type-A receptor 8 (EC 2.7.10.1) (Tyrosine-protein| kinase receptor EEK) (EPH- and ELK-related kinase) (Fragment) Length = 372 Score = 83.2 bits (204), Expect = 3e-16 Identities = 50/130 (38%), Positives = 72/130 (55%), Gaps = 5/130 (3%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLIS 220 IVT Y + GS+ FL + L+L V V GM Y+ LG+IHRDL + N+L+ Sbjct: 78 IVTEYMENGSLDAFLRTHDGQFTILQL-VGMLKGVGAGMRYLSDLGYIHRDLAARNILVD 136 Query: 221 GDKSIKIADFGVAR-IEVKTEGMTPETG---TYRWMAPEMIQHRPYNQKVDVYSFGIVLW 388 G K++DFG++R +E E G RW APE I R ++ DV+SFG+V+W Sbjct: 137 GRLVCKVSDFGLSRALEDDPEAAYTTAGGKIPIRWTAPEAIAFRTFSSASDVWSFGVVMW 196 Query: 389 ELIT-GTLPF 415 E++ G P+ Sbjct: 197 EVLAYGERPY 206
>EPHA6_MOUSE (Q62413) Ephrin type-A receptor 6 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2) Length = 1035 Score = 83.2 bits (204), Expect = 3e-16 Identities = 45/130 (34%), Positives = 76/130 (58%), Gaps = 5/130 (3%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLIS 220 IV Y + GS+ +FL + ++L V +A GM Y+ +G++HRDL + N+L++ Sbjct: 748 IVVEYMENGSLDSFLRKHDGHFTVIQL-VGMLRGIASGMKYLSDMGYVHRDLAARNILVN 806 Query: 221 GDKSIKIADFGVARI-EVKTEGMTPETG---TYRWMAPEMIQHRPYNQKVDVYSFGIVLW 388 + K++DFG++R+ E E TG RW APE I +R ++ D +S+GIV+W Sbjct: 807 SNLVCKVSDFGLSRVLEDDPEAAYTTTGGKIPIRWTAPEAIAYRKFSSASDAWSYGIVMW 866 Query: 389 ELIT-GTLPF 415 E+++ G P+ Sbjct: 867 EVMSYGERPY 876
>EPHA6_HUMAN (Q9UF33) Ephrin type-A receptor 6 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2) Length = 1035 Score = 83.2 bits (204), Expect = 3e-16 Identities = 45/130 (34%), Positives = 76/130 (58%), Gaps = 5/130 (3%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLIS 220 IV Y + GS+ +FL + ++L V +A GM Y+ +G++HRDL + N+L++ Sbjct: 748 IVVEYMENGSLDSFLRKHDGHFTVIQL-VGMLRGIASGMKYLSDMGYVHRDLAARNILVN 806 Query: 221 GDKSIKIADFGVARI-EVKTEGMTPETG---TYRWMAPEMIQHRPYNQKVDVYSFGIVLW 388 + K++DFG++R+ E E TG RW APE I +R ++ D +S+GIV+W Sbjct: 807 SNLVCKVSDFGLSRVLEDDPEAAYTTTGGKIPIRWTAPEAIAYRKFSSASDAWSYGIVMW 866 Query: 389 ELIT-GTLPF 415 E+++ G P+ Sbjct: 867 EVMSYGERPY 876
>EPHA3_CHICK (P29318) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ETK1) (CEK4) Length = 983 Score = 83.2 bits (204), Expect = 3e-16 Identities = 48/136 (35%), Positives = 80/136 (58%), Gaps = 5/136 (3%) Frame = +2 Query: 23 KPIVWCIVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKS 202 KP++ IVT Y + GS+ +FL + + ++L V +A GM Y+ +G++HRDL + Sbjct: 693 KPVM--IVTEYMENGSLDSFLRKHDAQFTVIQL-VGMLRGIASGMKYLSDMGYVHRDLAA 749 Query: 203 DNLLISGDKSIKIADFGVARI-EVKTEGMTPETG---TYRWMAPEMIQHRPYNQKVDVYS 370 N+LI+ + K++DFG++R+ E E G RW +PE I +R + D +S Sbjct: 750 RNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTSPEAIAYRKFTSASDAWS 809 Query: 371 FGIVLWELIT-GTLPF 415 +GIVLWE+++ G P+ Sbjct: 810 YGIVLWEVMSYGERPY 825
>EPHA3_MOUSE (P29319) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ETK1) (MEK4) Length = 983 Score = 82.8 bits (203), Expect = 3e-16 Identities = 46/130 (35%), Positives = 77/130 (59%), Gaps = 5/130 (3%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLIS 220 IVT Y + GS+ +FL + + ++L V +A GM Y+ +G++HRDL + N+LI+ Sbjct: 697 IVTEYMENGSLDSFLRKHDAQFTVIQL-VGMLRGIASGMKYLSDMGYVHRDLAARNILIN 755 Query: 221 GDKSIKIADFGVARI-EVKTEGMTPETG---TYRWMAPEMIQHRPYNQKVDVYSFGIVLW 388 + K++DFG++R+ E E G RW +PE + +R + DV+S+GIVLW Sbjct: 756 SNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTSPEAMSYRKFTSASDVWSYGIVLW 815 Query: 389 ELIT-GTLPF 415 E+++ G P+ Sbjct: 816 EVMSYGERPY 825
>EPHA3_RAT (O08680) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor REK4) (TYRO-4) Length = 984 Score = 82.8 bits (203), Expect = 3e-16 Identities = 48/136 (35%), Positives = 80/136 (58%), Gaps = 5/136 (3%) Frame = +2 Query: 23 KPIVWCIVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKS 202 KP++ IVT Y + GS+ +FL + + ++L V +A GM Y+ +G++HRDL + Sbjct: 694 KPVM--IVTEYMENGSLDSFLRKHDAQFTVIQL-VGMLRGIASGMKYLSDMGYVHRDLAA 750 Query: 203 DNLLISGDKSIKIADFGVARI-EVKTEGMTPETG---TYRWMAPEMIQHRPYNQKVDVYS 370 N+LI+ + K++DFG++R+ E E G RW +PE +R + DV+S Sbjct: 751 RNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPVRWTSPEATAYRKFTSASDVWS 810 Query: 371 FGIVLWELIT-GTLPF 415 +GIVLWE+++ G P+ Sbjct: 811 YGIVLWEVMSYGERPY 826
>SRMS_HUMAN (Q9H3Y6) Tyrosine-protein kinase Srms (EC 2.7.10.2)| Length = 488 Score = 82.8 bits (203), Expect = 3e-16 Identities = 47/131 (35%), Positives = 79/131 (60%), Gaps = 4/131 (3%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLIS 220 IVT + G+++ FL + R++ L + A VA GM+Y+ +HRDL + N+L+ Sbjct: 300 IVTELMRKGNLQAFLGTPEGRALRLPPLLGFACQVAEGMSYLEEQRVVHRDLAARNVLVD 359 Query: 221 GDKSIKIADFGVARIEVKTEGMTPETGT---YRWMAPEMIQHRPYNQKVDVYSFGIVLWE 391 + K+ADFG+AR+ +K + +P + + +W APE +R ++QK DV+SFG++L E Sbjct: 360 DGLACKVADFGLARL-LKDDIYSPSSSSKIPVKWTAPEAANYRVFSQKSDVWSFGVLLHE 418 Query: 392 LIT-GTLPFLG 421 + T G P+ G Sbjct: 419 VFTYGQCPYEG 429
>CLA4_CANAL (O14427) Serine/threonine-protein kinase CLA4 (EC 2.7.11.1)| Length = 971 Score = 82.8 bits (203), Expect = 3e-16 Identities = 45/131 (34%), Positives = 73/131 (55%), Gaps = 5/131 (3%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQ----ALDVARGMAYVHGLGFIHRDLKSDN 208 ++ Y +GGS+ + KL KQ + +G+ ++H IHRD+KSDN Sbjct: 754 VIMEYMQGGSLTEIIENND-----FKLNEKQIATICFETLKGLQHLHKKHIIHRDIKSDN 808 Query: 209 LLISGDKSIKIADFGV-ARIEVKTEGMTPETGTYRWMAPEMIQHRPYNQKVDVYSFGIVL 385 +L+ ++KI DFG A++ + GT WMAPE+++ + Y++KVDV+S GI+ Sbjct: 809 VLLDAYGNVKITDFGFCAKLTDQRNKRATMVGTPYWMAPEVVKQKEYDEKVDVWSLGIMT 868 Query: 386 WELITGTLPFL 418 E+I G P+L Sbjct: 869 IEMIEGEPPYL 879
>EPHA2_MOUSE (Q03145) Ephrin type-A receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2) Length = 977 Score = 82.8 bits (203), Expect = 3e-16 Identities = 47/136 (34%), Positives = 79/136 (58%), Gaps = 5/136 (3%) Frame = +2 Query: 23 KPIVWCIVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKS 202 KP++ I+T Y + G++ FL + L+L V +A GM Y+ + ++HRDL + Sbjct: 687 KPMM--IITEYMENGALDKFLREKDGEFSVLQL-VGMLRGIASGMKYLANMNYVHRDLAA 743 Query: 203 DNLLISGDKSIKIADFGVARI-EVKTEGMTPETG---TYRWMAPEMIQHRPYNQKVDVYS 370 N+L++ + K++DFG++R+ E E +G RW APE I +R + DV+S Sbjct: 744 RNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPEAISYRKFTSASDVWS 803 Query: 371 FGIVLWELIT-GTLPF 415 +GIV+WE++T G P+ Sbjct: 804 YGIVMWEVMTYGERPY 819
>EPA4A_BRARE (O13148) Ephrin type-A receptor 4a (EC 2.7.10.1) (Tyrosine-protein| kinase receptor ZEK2) (EPH-like kinase 2) (Fragment) Length = 292 Score = 82.8 bits (203), Expect = 3e-16 Identities = 50/145 (34%), Positives = 82/145 (56%), Gaps = 14/145 (9%) Frame = +2 Query: 23 KPIVWCIVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKS 202 KP++ I+T Y + GS+ FL + R ++L V +A GM Y+ + ++HRDL + Sbjct: 67 KPVM--IITEYMENGSLDAFLRKNDGRFTVIQL-VGILRGIASGMKYLSDMSYVHRDLAA 123 Query: 203 DNLLISGDKSIKIADFGVARI--EVKTEGMTPE--TGTY---------RWMAPEMIQHRP 343 N+L++ + K++DFG++R+ E T TGTY RW APE I +R Sbjct: 124 RNILVNSNLVCKVSDFGMSRVLEEDPDAAYTTREITGTYQSQGGKIPIRWTAPEAITYRK 183 Query: 344 YNQKVDVYSFGIVLWELIT-GTLPF 415 + DV+S+GIV+WE+++ G P+ Sbjct: 184 FTSASDVWSYGIVMWEVMSYGERPY 208
>CLA4_YEAST (P48562) Serine/threonine-protein kinase CLA4 (EC 2.7.11.1)| Length = 842 Score = 82.8 bits (203), Expect = 3e-16 Identities = 47/132 (35%), Positives = 74/132 (56%), Gaps = 6/132 (4%) Frame = +2 Query: 41 IVTGYAKGGSVRNFL-NRRQNRSVPLKLAVKQALDVAR----GMAYVHGLGFIHRDLKSD 205 +V + +GGS+ + + N N + L Q + R G+ ++H IHRD+KSD Sbjct: 638 VVMEFMEGGSLTDIIENSPTNDNSHSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSD 697 Query: 206 NLLISGDKSIKIADFGV-ARIEVKTEGMTPETGTYRWMAPEMIQHRPYNQKVDVYSFGIV 382 N+L+ +KI DFG AR+ K GT WMAPE+++ R Y++K+DV+S GI+ Sbjct: 698 NVLLDTRARVKITDFGFCARLTDKRSKRATMVGTPYWMAPEVVKQREYDEKIDVWSLGIM 757 Query: 383 LWELITGTLPFL 418 E++ G P+L Sbjct: 758 TIEMLEGEPPYL 769
>EPHA8_HUMAN (P29322) Ephrin type-A receptor 8 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) (HEK3) Length = 1005 Score = 82.4 bits (202), Expect = 4e-16 Identities = 47/130 (36%), Positives = 73/130 (56%), Gaps = 5/130 (3%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLIS 220 IVT Y + GS+ FL + ++L V V GM Y+ LG++HRDL + N+L+ Sbjct: 711 IVTEYMENGSLDTFLRTHDGQFTIMQL-VGMLRGVGAGMRYLSDLGYVHRDLAARNVLVD 769 Query: 221 GDKSIKIADFGVARI-EVKTEGMTPETG---TYRWMAPEMIQHRPYNQKVDVYSFGIVLW 388 + K++DFG++R+ E + TG RW APE I R ++ DV+SFG+V+W Sbjct: 770 SNLVCKVSDFGLSRVLEDDPDAAYTTTGGKIPIRWTAPEAIAFRTFSSASDVWSFGVVMW 829 Query: 389 ELIT-GTLPF 415 E++ G P+ Sbjct: 830 EVLAYGERPY 839
>KAPB_YEAST (P06245) cAMP-dependent protein kinase type 2 (EC 2.7.11.11) (PKA| 2) Length = 380 Score = 82.4 bits (202), Expect = 4e-16 Identities = 47/125 (37%), Positives = 77/125 (61%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLIS 220 +V Y +GG + + L R+++ P +A A +V + Y+H I+RDLK +N+L+ Sbjct: 145 MVMDYIEGGELFSLL--RKSQRFPNPVAKFYAAEVILALEYLHAHNIIYRDLKPENILLD 202 Query: 221 GDKSIKIADFGVARIEVKTEGMTPETGTYRWMAPEMIQHRPYNQKVDVYSFGIVLWELIT 400 + IKI DFG A+ EV+T T GT ++APE+I +PYN+ VD +S G++++E++ Sbjct: 203 RNGHIKITDFGFAK-EVQTVTWTL-CGTPDYIAPEVITTKPYNKSVDWWSLGVLIYEMLA 260 Query: 401 GTLPF 415 G PF Sbjct: 261 GYTPF 265
>AKT1_DROME (Q8INB9) RAC serine/threonine-protein kinase (EC 2.7.11.1)| (DRAC-PK) (Akt) (Dakt1) (Protein kinase B) (PKB) Length = 611 Score = 82.4 bits (202), Expect = 4e-16 Identities = 46/128 (35%), Positives = 70/128 (54%), Gaps = 2/128 (1%) Frame = +2 Query: 38 CIVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLI 217 C V Y GG + F + R ++ + Y+H G I+RDLK +NLL+ Sbjct: 340 CFVMQYVNGGEL--FWHLSHERIFTEDRTRFYGAEIISALGYLHSQGIIYRDLKLENLLL 397 Query: 218 SGDKSIKIADFGVARIEVKTEGMTPET--GTYRWMAPEMIQHRPYNQKVDVYSFGIVLWE 391 D IK+ADFG+ + ++ T G T +T GT ++APE++ Y Q VD + G+V++E Sbjct: 398 DKDGHIKVADFGLCKEDI-TYGRTTKTFCGTPEYLAPEVLDDNDYGQAVDWWGTGVVMYE 456 Query: 392 LITGTLPF 415 +I G LPF Sbjct: 457 MICGRLPF 464
>CEK3_CHICK (P18461) Tyrosine kinase receptor CEK3 precursor (EC 2.7.10.1)| Length = 823 Score = 82.4 bits (202), Expect = 4e-16 Identities = 53/160 (33%), Positives = 80/160 (50%), Gaps = 22/160 (13%) Frame = +2 Query: 8 VGACRKPIVWCIVTGYAKGGSVRNFL--------------NRRQNRSVPLKLAVKQALDV 145 +GAC + ++ YA G++R +L NR + K V + Sbjct: 553 LGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSFDINRVPEEQMTFKDLVSCTYQL 612 Query: 146 ARGMAYVHGLGFIHRDLKSDNLLISGDKSIKIADFGVAR-------IEVKTEGMTPETGT 304 ARGM Y+ IHRDL + N+L++ + +KIADFG+AR + T G P Sbjct: 613 ARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLP---- 668 Query: 305 YRWMAPEMIQHRPYNQKVDVYSFGIVLWELIT-GTLPFLG 421 +WMAPE + R Y + DV+SFG+++WE+ T G P+ G Sbjct: 669 VKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPG 708
>FGFR2_MOUSE (P21803) Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1)| (FGFR-2) (Keratinocyte growth factor receptor) Length = 821 Score = 82.4 bits (202), Expect = 4e-16 Identities = 53/160 (33%), Positives = 80/160 (50%), Gaps = 22/160 (13%) Frame = +2 Query: 8 VGACRKPIVWCIVTGYAKGGSVRNFL--------------NRRQNRSVPLKLAVKQALDV 145 +GAC + ++ YA G++R +L NR + K V + Sbjct: 551 LGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQL 610 Query: 146 ARGMAYVHGLGFIHRDLKSDNLLISGDKSIKIADFGVAR-------IEVKTEGMTPETGT 304 ARGM Y+ IHRDL + N+L++ + +KIADFG+AR + T G P Sbjct: 611 ARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLP---- 666 Query: 305 YRWMAPEMIQHRPYNQKVDVYSFGIVLWELIT-GTLPFLG 421 +WMAPE + R Y + DV+SFG+++WE+ T G P+ G Sbjct: 667 VKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPG 706
>FGFR2_HUMAN (P21802) Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1)| (FGFR-2) (Keratinocyte growth factor receptor 2) (CD332 antigen) Length = 821 Score = 82.4 bits (202), Expect = 4e-16 Identities = 53/160 (33%), Positives = 80/160 (50%), Gaps = 22/160 (13%) Frame = +2 Query: 8 VGACRKPIVWCIVTGYAKGGSVRNFL--------------NRRQNRSVPLKLAVKQALDV 145 +GAC + ++ YA G++R +L NR + K V + Sbjct: 551 LGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQL 610 Query: 146 ARGMAYVHGLGFIHRDLKSDNLLISGDKSIKIADFGVAR-------IEVKTEGMTPETGT 304 ARGM Y+ IHRDL + N+L++ + +KIADFG+AR + T G P Sbjct: 611 ARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLP---- 666 Query: 305 YRWMAPEMIQHRPYNQKVDVYSFGIVLWELIT-GTLPFLG 421 +WMAPE + R Y + DV+SFG+++WE+ T G P+ G Sbjct: 667 VKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPG 706
>SEA_AVIET (P23049) Tyrosine-protein kinase transforming protein SEA (EC| 2.7.10.2) Length = 370 Score = 82.4 bits (202), Expect = 4e-16 Identities = 48/131 (36%), Positives = 75/131 (57%), Gaps = 6/131 (4%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLIS 220 +V Y + G +R+F+ R Q RS +K + L VA GM Y+ F+HRDL + N ++ Sbjct: 137 VVLPYMRHGDLRHFV-RAQERSPTVKELIGFGLQVALGMEYLAQKKFVHRDLAARNCMLD 195 Query: 221 GDKSIKIADFGVARIEVKTEGMTPETGTY-----RWMAPEMIQHRPYNQKVDVYSFGIVL 385 ++K+ADFG+AR E + + RWMA E +Q + + K DV+SFG+++ Sbjct: 196 ETLTVKVADFGLARDVFGKEYYSIRQHRHAKLPVRWMALESLQTQKFTTKSDVWSFGVLM 255 Query: 386 WELIT-GTLPF 415 WEL+T G P+ Sbjct: 256 WELLTRGASPY 266
>KPCG_BOVIN (P05128) Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma)| (Fragment) Length = 682 Score = 82.0 bits (201), Expect = 6e-16 Identities = 47/128 (36%), Positives = 74/128 (57%), Gaps = 2/128 (1%) Frame = +2 Query: 44 VTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLISG 223 V Y GG + + + P A A ++A G+ ++H G I+RDLK DN+++ Sbjct: 418 VMEYVTGGDLMYHIQQLGKFKEPH--AAFYAAEIAIGLFFLHNQGIIYRDLKLDNVMLDA 475 Query: 224 DKSIKIADFGVARIEVKTEGMTPET--GTYRWMAPEMIQHRPYNQKVDVYSFGIVLWELI 397 + IKI DFG+ + V G T T GT ++APE+I ++PY + VD +SFG++L+E++ Sbjct: 476 EGHIKITDFGMCKENV-FPGSTTRTFCGTPDYIAPEIIAYQPYGKSVDWWSFGVLLYEML 534 Query: 398 TGTLPFLG 421 G PF G Sbjct: 535 AGQPPFDG 542
>AAPK1_CAEEL (P45894) 5'-AMP-activated protein kinase catalytic subunit alpha-1| (EC 2.7.11.1) (AMP-activated kinase 1) Length = 589 Score = 82.0 bits (201), Expect = 6e-16 Identities = 40/126 (31%), Positives = 78/126 (61%), Gaps = 1/126 (0%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLIS 220 +V GG + +++ R+ ++P++ + + + G++Y H +HRDLK +NLL+ Sbjct: 99 LVMELVSGGELFSYITRKG--ALPIRESRRYFQQIISGVSYCHNHMIVHRDLKPENLLLD 156 Query: 221 GDKSIKIADFGVARIEVKTEGMTPETGTYRWMAPEMIQHRPY-NQKVDVYSFGIVLWELI 397 +K+IKIADFG++ + ++ G+ + APE+I ++ Y +VD++S G++L+ ++ Sbjct: 157 ANKNIKIADFGLSNYMTDGDLLSTACGSPNYAAPELISNKLYVGPEVDLWSCGVILYAML 216 Query: 398 TGTLPF 415 GTLPF Sbjct: 217 CGTLPF 222
>KS6A3_MOUSE (P18654) Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1)| (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B) Length = 740 Score = 82.0 bits (201), Expect = 6e-16 Identities = 37/95 (38%), Positives = 63/95 (66%), Gaps = 1/95 (1%) Frame = +2 Query: 140 DVARGMAYVHGLGFIHRDLKSDNLLISGDKSIKIADFGVARIEVKTEGMTPE-TGTYRWM 316 ++A + ++H LG I+RDLK +N+L+ + IK+ DFG+++ + E GT +M Sbjct: 176 ELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYM 235 Query: 317 APEMIQHRPYNQKVDVYSFGIVLWELITGTLPFLG 421 APE++ R + Q D +SFG++++E++TGTLPF G Sbjct: 236 APEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQG 270 Score = 69.7 bits (169), Expect = 3e-12 Identities = 46/135 (34%), Positives = 79/135 (58%), Gaps = 7/135 (5%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLI- 217 +VT KGG + + + R++ S AV + + + Y+H G +HRDLK N+L Sbjct: 491 VVTELMKGGELLDKILRQKFFSEREASAV--LFTITKTVEYLHAQGVVHRDLKPSNILYV 548 Query: 218 --SGD-KSIKIADFGVARIEVKTEG---MTPETGTYRWMAPEMIQHRPYNQKVDVYSFGI 379 SG+ +SI+I DFG A+ +++ E MTP T ++APE+++ + Y+ D++S G+ Sbjct: 549 DESGNPESIRICDFGFAK-QLRAENGLLMTP-CYTANFVAPEVLKRQGYDAACDIWSLGV 606 Query: 380 VLWELITGTLPFLGG 424 +L+ ++TG PF G Sbjct: 607 LLYTMLTGYTPFANG 621
>KS6A3_HUMAN (P51812) Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1)| (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protei Length = 740 Score = 82.0 bits (201), Expect = 6e-16 Identities = 37/95 (38%), Positives = 63/95 (66%), Gaps = 1/95 (1%) Frame = +2 Query: 140 DVARGMAYVHGLGFIHRDLKSDNLLISGDKSIKIADFGVARIEVKTEGMTPE-TGTYRWM 316 ++A + ++H LG I+RDLK +N+L+ + IK+ DFG+++ + E GT +M Sbjct: 176 ELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYM 235 Query: 317 APEMIQHRPYNQKVDVYSFGIVLWELITGTLPFLG 421 APE++ R + Q D +SFG++++E++TGTLPF G Sbjct: 236 APEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQG 270 Score = 69.7 bits (169), Expect = 3e-12 Identities = 46/135 (34%), Positives = 79/135 (58%), Gaps = 7/135 (5%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLI- 217 +VT KGG + + + R++ S AV + + + Y+H G +HRDLK N+L Sbjct: 491 VVTELMKGGELLDKILRQKFFSEREASAV--LFTITKTVEYLHAQGVVHRDLKPSNILYV 548 Query: 218 --SGD-KSIKIADFGVARIEVKTEG---MTPETGTYRWMAPEMIQHRPYNQKVDVYSFGI 379 SG+ +SI+I DFG A+ +++ E MTP T ++APE+++ + Y+ D++S G+ Sbjct: 549 DESGNPESIRICDFGFAK-QLRAENGLLMTP-CYTANFVAPEVLKRQGYDAACDIWSLGV 606 Query: 380 VLWELITGTLPFLGG 424 +L+ ++TG PF G Sbjct: 607 LLYTMLTGYTPFANG 621
>PKPA_PHYBL (Q01577) Serine/threonine-protein kinase pkpA (EC 2.7.11.1)| Length = 613 Score = 82.0 bits (201), Expect = 6e-16 Identities = 47/127 (37%), Positives = 73/127 (57%), Gaps = 3/127 (2%) Frame = +2 Query: 44 VTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLG--FIHRDLKSDNLLI 217 +T G++R ++ R+ +K+ + + +G+AY+HG IHRD+K DN+ I Sbjct: 90 ITELMTSGTLREYI-RKLTPLPNIKIVKRWCRQILKGLAYLHGHEPPIIHRDIKCDNIFI 148 Query: 218 SGDKS-IKIADFGVARIEVKTEGMTPETGTYRWMAPEMIQHRPYNQKVDVYSFGIVLWEL 394 +G IKI D G A E+K GT +MAPEM + + YN+KVD+Y+FG+ L E+ Sbjct: 149 NGAHGEIKIGDMGTA--EMKNGKKYTVIGTPEFMAPEMYEEQGYNEKVDIYAFGMCLLEM 206 Query: 395 ITGTLPF 415 TG P+ Sbjct: 207 ATGEYPY 213
>KPCA_MOUSE (P20444) Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha)| (PKC-A) Length = 671 Score = 82.0 bits (201), Expect = 6e-16 Identities = 45/128 (35%), Positives = 79/128 (61%), Gaps = 2/128 (1%) Frame = +2 Query: 44 VTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLISG 223 V Y GG + + + P AV A +++ G+ ++H G I+RDLK +N++++ Sbjct: 415 VMEYVNGGDLMYHIQQVGKFKEPQ--AVFYAAEISIGLFFLHKRGIIYRDLKLNNVMLNS 472 Query: 224 DKSIKIADFGVARIEVKTEGMTPET--GTYRWMAPEMIQHRPYNQKVDVYSFGIVLWELI 397 + IKIADFG+ + E +G+T T GT ++APE+I ++PY + VD +++G++L+E++ Sbjct: 473 EGHIKIADFGMCK-EHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEML 531 Query: 398 TGTLPFLG 421 G PF G Sbjct: 532 AGQPPFDG 539
>PKN2_COREF (Q8FUI4) Serine/threonine protein kinases drp72 (EC 2.7.11.1)| Length = 520 Score = 82.0 bits (201), Expect = 6e-16 Identities = 45/131 (34%), Positives = 75/131 (57%), Gaps = 4/131 (3%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLIS 220 IV Y +G S+ + L R ++P +LA+ A G++ +H +G +HRD+K N+LI+ Sbjct: 100 IVLEYIRGESLADMLEREG--ALPEELALDVMEQAAHGLSVIHRMGLVHRDIKPGNMLIT 157 Query: 221 GDKSIKIADFGVAR----IEVKTEGMTPETGTYRWMAPEMIQHRPYNQKVDVYSFGIVLW 388 + +KI DFG+A+ + + GM GT ++++PE Q DVYS G+V + Sbjct: 158 ANGILKITDFGIAKAAASVPLTRTGMV--VGTAQYVSPEQAQGHQVTPASDVYSLGVVGY 215 Query: 389 ELITGTLPFLG 421 E+++G PF G Sbjct: 216 EMLSGRRPFTG 226
>NTRK1_CHICK (Q91009) High affinity nerve growth factor receptor precursor (EC| 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (Trk-A) (Fragment) Length = 778 Score = 82.0 bits (201), Expect = 6e-16 Identities = 51/149 (34%), Positives = 73/149 (48%), Gaps = 16/149 (10%) Frame = +2 Query: 2 KFVGACRKPIVWCIVTGYAKGGSVRNFLNRR--------QNRSVP-----LKLAVKQALD 142 KF G C + +V Y K G + FL Q + P L ++ A Sbjct: 557 KFYGVCTEGDPLIMVFEYMKHGDLNRFLRSHGPDAKILDQGQGQPCGQLTLSHMLQIATQ 616 Query: 143 VARGMAYVHGLGFIHRDLKSDNLLISGDKSIKIADFGVARIEVKTEGMTPETGT---YRW 313 +A GM Y+ L F+HRDL + N L+ D +KI DFG++R T+ T RW Sbjct: 617 IASGMVYLASLHFVHRDLATRNCLVGHDLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRW 676 Query: 314 MAPEMIQHRPYNQKVDVYSFGIVLWELIT 400 M PE I +R + + D++SFG+VLWE+ T Sbjct: 677 MPPESILYRKFTTESDIWSFGVVLWEIFT 705
>PK1_STRTO (Q9KIG4) Serine/threonine-protein kinase PK-1 (EC 2.7.11.1)| (stoPK-1) Length = 641 Score = 82.0 bits (201), Expect = 6e-16 Identities = 46/124 (37%), Positives = 71/124 (57%), Gaps = 1/124 (0%) Frame = +2 Query: 53 YAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLISGDKS 232 Y G ++R+ L R L + + + A G A H GF+HRD+K +N+LI D Sbjct: 97 YIAGCTLRDVLRERGALQPRAALDILEPVLAALGAA--HRAGFVHRDMKPENVLIGDDGR 154 Query: 233 IKIADFGVAR-IEVKTEGMTPETGTYRWMAPEMIQHRPYNQKVDVYSFGIVLWELITGTL 409 +K+ADFG+ R ++ T GT ++APE I+H + +VDVY+ GI+L+E++TG Sbjct: 155 VKVADFGLVRAVDSVTNTTGTVLGTVSYLAPEQIEHGTADPRVDVYACGILLYEMLTGEK 214 Query: 410 PFLG 421 P G Sbjct: 215 PHDG 218
>KPCG_RAT (P63319) Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma)| Length = 697 Score = 82.0 bits (201), Expect = 6e-16 Identities = 47/128 (36%), Positives = 74/128 (57%), Gaps = 2/128 (1%) Frame = +2 Query: 44 VTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLISG 223 V Y GG + + + P A A ++A G+ ++H G I+RDLK DN+++ Sbjct: 433 VMEYVTGGDLMYHIQQLGKFKEPH--AAFYAAEIAIGLFFLHNQGIIYRDLKLDNVMLDA 490 Query: 224 DKSIKIADFGVARIEVKTEGMTPET--GTYRWMAPEMIQHRPYNQKVDVYSFGIVLWELI 397 + IKI DFG+ + V G T T GT ++APE+I ++PY + VD +SFG++L+E++ Sbjct: 491 EGHIKITDFGMCKENV-FPGSTTRTFCGTPDYIAPEIIAYQPYGKSVDWWSFGVLLYEML 549 Query: 398 TGTLPFLG 421 G PF G Sbjct: 550 AGQPPFDG 557
>KPCG_RABIT (P10829) Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma)| (PKC-delta) Length = 697 Score = 82.0 bits (201), Expect = 6e-16 Identities = 47/128 (36%), Positives = 74/128 (57%), Gaps = 2/128 (1%) Frame = +2 Query: 44 VTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLISG 223 V Y GG + + + P A A ++A G+ ++H G I+RDLK DN+++ Sbjct: 433 VMEYVTGGDLMYHIQQLGKFKEPH--AAFYAAEIAIGLFFLHNQGIIYRDLKLDNVMLDA 490 Query: 224 DKSIKIADFGVARIEVKTEGMTPET--GTYRWMAPEMIQHRPYNQKVDVYSFGIVLWELI 397 + IKI DFG+ + V G T T GT ++APE+I ++PY + VD +SFG++L+E++ Sbjct: 491 EGHIKITDFGMCKENV-FPGTTTRTFCGTPDYIAPEIIAYQPYGKSVDWWSFGVLLYEML 549 Query: 398 TGTLPFLG 421 G PF G Sbjct: 550 AGQPPFDG 557
>KPCG_MOUSE (P63318) Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma)| Length = 697 Score = 82.0 bits (201), Expect = 6e-16 Identities = 47/128 (36%), Positives = 74/128 (57%), Gaps = 2/128 (1%) Frame = +2 Query: 44 VTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLISG 223 V Y GG + + + P A A ++A G+ ++H G I+RDLK DN+++ Sbjct: 433 VMEYVTGGDLMYHIQQLGKFKEPH--AAFYAAEIAIGLFFLHNQGIIYRDLKLDNVMLDA 490 Query: 224 DKSIKIADFGVARIEVKTEGMTPET--GTYRWMAPEMIQHRPYNQKVDVYSFGIVLWELI 397 + IKI DFG+ + V G T T GT ++APE+I ++PY + VD +SFG++L+E++ Sbjct: 491 EGHIKITDFGMCKENV-FPGSTTRTFCGTPDYIAPEIIAYQPYGKSVDWWSFGVLLYEML 549 Query: 398 TGTLPFLG 421 G PF G Sbjct: 550 AGQPPFDG 557
>KPCG_HUMAN (P05129) Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma)| Length = 697 Score = 82.0 bits (201), Expect = 6e-16 Identities = 47/128 (36%), Positives = 74/128 (57%), Gaps = 2/128 (1%) Frame = +2 Query: 44 VTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLISG 223 V Y GG + + + P A A ++A G+ ++H G I+RDLK DN+++ Sbjct: 433 VMEYVTGGDLMYHIQQLGKFKEPH--AAFYAAEIAIGLFFLHNQGIIYRDLKLDNVMLDA 490 Query: 224 DKSIKIADFGVARIEVKTEGMTPET--GTYRWMAPEMIQHRPYNQKVDVYSFGIVLWELI 397 + IKI DFG+ + V G T T GT ++APE+I ++PY + VD +SFG++L+E++ Sbjct: 491 EGHIKITDFGMCKENV-FPGTTTRTFCGTPDYIAPEIIAYQPYGKSVDWWSFGVLLYEML 549 Query: 398 TGTLPFLG 421 G PF G Sbjct: 550 AGQPPFDG 557
>KPC1_APLCA (Q16974) Calcium-dependent protein kinase C (EC 2.7.11.13) (APL I)| Length = 649 Score = 82.0 bits (201), Expect = 6e-16 Identities = 42/127 (33%), Positives = 75/127 (59%), Gaps = 1/127 (0%) Frame = +2 Query: 44 VTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLISG 223 V Y GG + + + P+ A A ++A G+ Y+H G ++RDLK DN+++ Sbjct: 397 VMEYVNGGDLMYRIQQEGKFKEPV--AAFYAAEIAIGLFYLHTQGIVYRDLKLDNVMLDA 454 Query: 224 DKSIKIADFGVARIEVKTEGMTPE-TGTYRWMAPEMIQHRPYNQKVDVYSFGIVLWELIT 400 + IKIADFG+ + + + T GT ++APE++ ++PY + VD +++G++L+E++ Sbjct: 455 EGHIKIADFGMCKENIMGDKTTRTFCGTPDYIAPEIVLYQPYGRSVDWWAYGVLLYEMLA 514 Query: 401 GTLPFLG 421 G PF G Sbjct: 515 GQPPFDG 521
>FGFR2_XENLA (Q03364) Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1)| (FGFR-2) Length = 813 Score = 82.0 bits (201), Expect = 6e-16 Identities = 52/157 (33%), Positives = 81/157 (51%), Gaps = 19/157 (12%) Frame = +2 Query: 8 VGACRKPIVWCIVTGYAKGGSVRNFLNRRQ--------------NRSVPLKLAVKQALDV 145 +GAC + ++ YA G++R +L R+ + + K V + Sbjct: 541 LGACTQGGTLYVIVEYAAKGNLRQYLRARRPLEMEYSFDVTRVPDEQMTFKDLVSCTYQI 600 Query: 146 ARGMAYVHGLGFIHRDLKSDNLLISGDKSIKIADFGVARIEVKTEGMTPETGTYR----W 313 ARGM Y+ IHRDL + N+L++ + +KIADFG+AR +V +T R W Sbjct: 601 ARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLAR-DVNNIDYYKKTSNGRLPVKW 659 Query: 314 MAPEMIQHRPYNQKVDVYSFGIVLWELIT-GTLPFLG 421 MAPE + R Y + DV+SFG+++WE+ T G P+ G Sbjct: 660 MAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPG 696
>KKK1_YEAST (P34244) Probable serine/threonine-protein kinase YKL101W (EC| 2.7.11.1) Length = 1518 Score = 82.0 bits (201), Expect = 6e-16 Identities = 46/127 (36%), Positives = 75/127 (59%), Gaps = 2/127 (1%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLIS 220 +V Y GG + ++L + +P + A+ + G++Y H HRDLK +NLL+ Sbjct: 191 LVLEYVDGGELFDYLVSKGK--LPEREAIHYFKQIVEGVSYCHSFNICHRDLKPENLLLD 248 Query: 221 G-DKSIKIADFGVARIEVKTEGMTPETGTYRWMAPEMIQHRPYN-QKVDVYSFGIVLWEL 394 ++ IKIADFG+A +E+ + + G+ + +PE++ RPY+ DV+S GIVL+ L Sbjct: 249 KKNRRIKIADFGMAALELPNKLLKTSCGSPHYASPEIVMGRPYHGGPSDVWSCGIVLFAL 308 Query: 395 ITGTLPF 415 +TG LPF Sbjct: 309 LTGHLPF 315
>ABL_FSVHY (P10447) Tyrosine-protein kinase transforming protein Abl (EC| 2.7.10.2) (V-abl) Length = 439 Score = 82.0 bits (201), Expect = 6e-16 Identities = 43/144 (29%), Positives = 80/144 (55%), Gaps = 4/144 (2%) Frame = +2 Query: 2 KFVGACRKPIVWCIVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGF 181 + +G C + + I+T + G++ ++L + V + + A ++ M Y+ F Sbjct: 249 QLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNF 308 Query: 182 IHRDLKSDNLLISGDKSIKIADFGVARIEVKTEGMTPETGT---YRWMAPEMIQHRPYNQ 352 IHRDL + N L+ + +K+ADFG++R+ + + T GT +W APE + + ++ Sbjct: 309 IHRDLAARNCLVGENHLVKVADFGLSRL-MTGDTYTAHAGTKFPIKWTAPESLAYNKFSI 367 Query: 353 KVDVYSFGIVLWELIT-GTLPFLG 421 K DV++FG++LWE+ T G P+ G Sbjct: 368 KSDVWAFGVLLWEIATYGMSPYPG 391
>EPHA4_MOUSE (Q03137) Ephrin type-A receptor 4 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor SEK) (MPK-3) Length = 986 Score = 81.6 bits (200), Expect = 7e-16 Identities = 46/136 (33%), Positives = 78/136 (57%), Gaps = 5/136 (3%) Frame = +2 Query: 23 KPIVWCIVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKS 202 KP++ I+T Y + GS+ FL + R ++L V + GM Y+ + ++HRDL + Sbjct: 693 KPVM--IITEYMENGSLDAFLRKNDGRFTVIQL-VGMLRGIGSGMKYLSDMSYVHRDLAA 749 Query: 203 DNLLISGDKSIKIADFGVARI-EVKTEGMTPETG---TYRWMAPEMIQHRPYNQKVDVYS 370 N+L++ + K++DFG++R+ E E G RW APE I +R + DV+S Sbjct: 750 RNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAYRKFTSASDVWS 809 Query: 371 FGIVLWELIT-GTLPF 415 +GIV+WE+++ G P+ Sbjct: 810 YGIVMWEVMSYGERPY 825
>EPHA4_HUMAN (P54764) Ephrin type-A receptor 4 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor SEK) (Receptor protein-tyrosine kinase HEK8) Length = 986 Score = 81.6 bits (200), Expect = 7e-16 Identities = 46/136 (33%), Positives = 78/136 (57%), Gaps = 5/136 (3%) Frame = +2 Query: 23 KPIVWCIVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKS 202 KP++ I+T Y + GS+ FL + R ++L V + GM Y+ + ++HRDL + Sbjct: 693 KPVM--IITEYMENGSLDAFLRKNDGRFTVIQL-VGMLRGIGSGMKYLSDMSYVHRDLAA 749 Query: 203 DNLLISGDKSIKIADFGVARI-EVKTEGMTPETG---TYRWMAPEMIQHRPYNQKVDVYS 370 N+L++ + K++DFG++R+ E E G RW APE I +R + DV+S Sbjct: 750 RNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAYRKFTSASDVWS 809 Query: 371 FGIVLWELIT-GTLPF 415 +GIV+WE+++ G P+ Sbjct: 810 YGIVMWEVMSYGERPY 825
>EPHA4_CHICK (Q07496) Ephrin type-A receptor 4 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor CEK8) Length = 986 Score = 81.6 bits (200), Expect = 7e-16 Identities = 46/136 (33%), Positives = 78/136 (57%), Gaps = 5/136 (3%) Frame = +2 Query: 23 KPIVWCIVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKS 202 KP++ I+T Y + GS+ FL + R ++L V + GM Y+ + ++HRDL + Sbjct: 693 KPVM--IITEYMENGSLDAFLRKNDGRFTVIQL-VGMLRGIGSGMKYLSDMSYVHRDLAA 749 Query: 203 DNLLISGDKSIKIADFGVARI-EVKTEGMTPETG---TYRWMAPEMIQHRPYNQKVDVYS 370 N+L++ + K++DFG++R+ E E G RW APE I +R + DV+S Sbjct: 750 RNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAYRKFTSASDVWS 809 Query: 371 FGIVLWELIT-GTLPF 415 +GIV+WE+++ G P+ Sbjct: 810 YGIVMWEVMSYGERPY 825
>SRK1_SPOLA (P42686) Tyrosine-protein kinase isoform SRK1 (EC 2.7.10.2)| Length = 505 Score = 81.6 bits (200), Expect = 7e-16 Identities = 52/138 (37%), Positives = 76/138 (55%), Gaps = 3/138 (2%) Frame = +2 Query: 17 CRKPIVWCIVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDL 196 C K IVT K GS+ +L R ++ + ++ V A VA GM+Y+ +IHRDL Sbjct: 302 CTKEEPIYIVTELMKYGSLLEYL-RGEDGVLKIEQLVDVAAQVASGMSYLEQQNYIHRDL 360 Query: 197 KSDNLLISGDKSIKIADFGVARI--EVKTEGMTPETGTYRWMAPEMIQHRPYNQKVDVYS 370 + N+L+ K+ADFG+AR+ E E T +W APE + + K DV+S Sbjct: 361 AARNILVGEHGICKVADFGLARVIDEEIYEAHTGAKFPIKWTAPEAAMYNRFTIKSDVWS 420 Query: 371 FGIVLWELIT-GTLPFLG 421 FG+VL+E+IT G P+ G Sbjct: 421 FGVVLYEIITYGRFPYPG 438
>EPHA3_BRARE (O13146) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ZEK1) (EPH-like kinase 1) Length = 981 Score = 81.6 bits (200), Expect = 7e-16 Identities = 47/136 (34%), Positives = 79/136 (58%), Gaps = 5/136 (3%) Frame = +2 Query: 23 KPIVWCIVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKS 202 KP++ IVT Y + GS+ FL + + ++L + +A GM Y+ + ++HRDL + Sbjct: 698 KPVM--IVTEYMENGSLDTFLKKHDGQFTVIQL-LGMLRGIAAGMQYLSEMNYVHRDLAA 754 Query: 203 DNLLISGDKSIKIADFGVARI-EVKTEGMTPETG---TYRWMAPEMIQHRPYNQKVDVYS 370 N+L++ + K++DFG++R+ E E G RW APE I +R + DV+S Sbjct: 755 RNILVNRNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAITYRKFTSASDVWS 814 Query: 371 FGIVLWELIT-GTLPF 415 +GIV+WE+I+ G P+ Sbjct: 815 YGIVMWEVISYGERPY 830
>EPA4B_XENLA (Q91694) Ephrin type-A receptor 4-B precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor PAG) (Pagliaccio) Length = 985 Score = 81.6 bits (200), Expect = 7e-16 Identities = 46/136 (33%), Positives = 78/136 (57%), Gaps = 5/136 (3%) Frame = +2 Query: 23 KPIVWCIVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKS 202 KP++ I+T Y + GS+ FL + R ++L V + GM Y+ + ++HRDL + Sbjct: 692 KPVM--IITEYMENGSLDAFLRKNDGRFTVIQL-VGMLRGIGSGMKYLSDMSYVHRDLAA 748 Query: 203 DNLLISGDKSIKIADFGVARI-EVKTEGMTPETG---TYRWMAPEMIQHRPYNQKVDVYS 370 N+L++ + K++DFG++R+ E E G RW APE I +R + DV+S Sbjct: 749 RNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAYRKFTSASDVWS 808 Query: 371 FGIVLWELIT-GTLPF 415 +GIV+WE+++ G P+ Sbjct: 809 YGIVMWEVMSYGERPY 824
>EPHA8_MOUSE (O09127) Ephrin type-A receptor 8 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) Length = 1004 Score = 81.6 bits (200), Expect = 7e-16 Identities = 49/130 (37%), Positives = 72/130 (55%), Gaps = 5/130 (3%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLIS 220 IVT Y + GS+ FL + ++L V V GM Y+ LG+IHRDL + N+L+ Sbjct: 710 IVTEYMENGSLDAFLRTHDGQFTIVQL-VGMLRGVGAGMRYLSDLGYIHRDLAARNVLVD 768 Query: 221 GDKSIKIADFGVAR-IEVKTEGMTPETG---TYRWMAPEMIQHRPYNQKVDVYSFGIVLW 388 G K++DFG++R +E E G RW APE I R ++ DV+SFG+V+W Sbjct: 769 GRLVCKVSDFGLSRALEDDPEAAYTTAGGKIPIRWTAPEAIAFRTFSSASDVWSFGVVMW 828 Query: 389 ELIT-GTLPF 415 E++ G P+ Sbjct: 829 EVLAYGERPY 838
>FPS_AVISP (P00541) Tyrosine-protein kinase transforming protein Fps (EC| 2.7.10.2) Length = 533 Score = 81.3 bits (199), Expect = 1e-15 Identities = 48/144 (33%), Positives = 79/144 (54%), Gaps = 6/144 (4%) Frame = +2 Query: 2 KFVGACRKPIVWCIVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGF 181 + +G C + IV +GG +FL R + + +K +K + A GM Y+ Sbjct: 332 RLIGVCTQKQPIYIVMELVQGGDFLSFL-RSKGPHLKMKELIKMMENAAAGMEYLESKHC 390 Query: 182 IHRDLKSDNLLISGDKSIKIADFGVARIEVKTEGMTPETG-----TYRWMAPEMIQHRPY 346 IHRDL + N L++ ++KI+DFG++R E +G+ TG +W APE + + Y Sbjct: 391 IHRDLAARNCLVTEKNTLKISDFGMSRQE--EDGVYASTGGMKQIPVKWTAPEALNYGRY 448 Query: 347 NQKVDVYSFGIVLWELIT-GTLPF 415 + + DV+SFGI+LWE + G +P+ Sbjct: 449 SSESDVWSFGILLWEAFSLGAVPY 472
>CAD96_DROME (Q9VBW3) Tyrosine kinase receptor Cad96Ca precursor (EC 2.7.10.1)| (Cadherin 96Ca) (Tyrosine kinase receptor HD-14) Length = 773 Score = 81.3 bits (199), Expect = 1e-15 Identities = 44/101 (43%), Positives = 63/101 (62%), Gaps = 8/101 (7%) Frame = +2 Query: 143 VARGMAYVHGLGFIHRDLKSDNLLISGDKSIKIADFGVAR-------IEVKTEGMTPETG 301 VA+GM Y+ G IHRDL + N+LI+ D + K+ADFG AR E K+EG P Sbjct: 594 VAKGMDYLTSRGIIHRDLAARNILITDDHTCKVADFGFARDVITSKIYERKSEGKLP--- 650 Query: 302 TYRWMAPEMIQHRPYNQKVDVYSFGIVLWELIT-GTLPFLG 421 RWMA E + ++ K D++SFGI++WE++T G+ P+ G Sbjct: 651 -IRWMATESLYDNIFSVKSDIWSFGILMWEIVTLGSTPYPG 690
>FGFR4_HUMAN (P22455) Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1)| (FGFR-4) (CD334 antigen) Length = 802 Score = 81.3 bits (199), Expect = 1e-15 Identities = 55/160 (34%), Positives = 79/160 (49%), Gaps = 22/160 (13%) Frame = +2 Query: 8 VGACRKPIVWCIVTGYAKGGSVRNFLNRRQNRSVPLK--------------LAVKQALDV 145 +G C + ++ A G++R FL R+ L + V A V Sbjct: 537 LGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQV 596 Query: 146 ARGMAYVHGLGFIHRDLKSDNLLISGDKSIKIADFGVAR-------IEVKTEGMTPETGT 304 ARGM Y+ IHRDL + N+L++ D +KIADFG+AR + + G P Sbjct: 597 ARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLP---- 652 Query: 305 YRWMAPEMIQHRPYNQKVDVYSFGIVLWELIT-GTLPFLG 421 +WMAPE + R Y + DV+SFGI+LWE+ T G P+ G Sbjct: 653 VKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPG 692
>KPC4_DROME (P83099) Putative protein kinase C, delta type homolog (EC| 2.7.11.13) Length = 643 Score = 81.3 bits (199), Expect = 1e-15 Identities = 37/95 (38%), Positives = 63/95 (66%), Gaps = 1/95 (1%) Frame = +2 Query: 140 DVARGMAYVHGLGFIHRDLKSDNLLISGDKSIKIADFGVARIEVKTEGMTPE-TGTYRWM 316 ++ G+ ++H G I+RDLK DN+L+ + ++IADFG+ ++++ + GT +M Sbjct: 422 EIISGLKFLHKKGIIYRDLKLDNVLLDYEGHVRIADFGMCKLQIYLDKTADSFCGTPDYM 481 Query: 317 APEMIQHRPYNQKVDVYSFGIVLWELITGTLPFLG 421 APE+I+ YNQ VD +SFG++L+E++ G PF G Sbjct: 482 APEIIKGEKYNQNVDWWSFGVLLYEMLIGQSPFSG 516
>CLA4_ASHGO (Q9HFW2) Serine/threonine-protein kinase CLA4 (EC 2.7.11.1)| Length = 793 Score = 81.3 bits (199), Expect = 1e-15 Identities = 45/132 (34%), Positives = 74/132 (56%), Gaps = 6/132 (4%) Frame = +2 Query: 41 IVTGYAKGGS----VRNFLNRRQNRSVPLKLAVKQAL-DVARGMAYVHGLGFIHRDLKSD 205 +V Y +GGS + N + + S + + + + +G+ ++H IHRD+KSD Sbjct: 589 VVMEYMEGGSLTDVIENSIGSDASESPMTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSD 648 Query: 206 NLLISGDKSIKIADFGV-ARIEVKTEGMTPETGTYRWMAPEMIQHRPYNQKVDVYSFGIV 382 N+L+ +KI DFG A++ K GT WMAPE+++ R Y++KVDV+S GI+ Sbjct: 649 NVLLDTHGRVKITDFGFCAKLTDKRSKRATMVGTPYWMAPEVVKQREYDEKVDVWSLGIM 708 Query: 383 LWELITGTLPFL 418 E++ G P+L Sbjct: 709 TIEMLEGEPPYL 720
>PKNB_MYCLE (P54744) Probable serine/threonine-protein kinase pknB (EC| 2.7.11.1) Length = 622 Score = 81.3 bits (199), Expect = 1e-15 Identities = 42/130 (32%), Positives = 75/130 (57%), Gaps = 3/130 (2%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLIS 220 IV Y G ++R+ ++ + +P + A++ D + + + H G IHRD+K N++IS Sbjct: 90 IVMEYVDGATLRDIVHT--DGPMPPQQAIEIVADACQALNFSHQNGIIHRDVKPANIMIS 147 Query: 221 GDKSIKIADFGVARIEVKTEGMTPET---GTYRWMAPEMIQHRPYNQKVDVYSFGIVLWE 391 ++K+ DFG+AR + +T GT ++++PE + + + DVYS G VL+E Sbjct: 148 ATNAVKVMDFGIARAIADSTSVTQTAAVIGTAQYLSPEQARGDSVDARSDVYSLGCVLYE 207 Query: 392 LITGTLPFLG 421 ++TG PF+G Sbjct: 208 ILTGEPPFIG 217
>KIN1_YEAST (P13185) Protein kinase KIN1 (EC 2.7.11.1)| Length = 1064 Score = 81.3 bits (199), Expect = 1e-15 Identities = 44/122 (36%), Positives = 72/122 (59%), Gaps = 1/122 (0%) Frame = +2 Query: 53 YAKGGSVRNFLNRRQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNLLISGDKS 232 Y GG + +++ Q+ S+ A K A +A + Y+H +HRDLK +N++IS Sbjct: 225 YVSGGQLLDYII--QHGSIREHQARKFARGIASALIYLHANNIVHRDLKIENIMISDSSE 282 Query: 233 IKIADFGVARIEVKTEGMTPETGTYRWMAPEMIQHRPY-NQKVDVYSFGIVLWELITGTL 409 IKI DFG++ I + + G+ + APE+++ PY +VDV+SFG+VL+ L+ G + Sbjct: 283 IKIIDFGLSNIYDSRKQLHTFCGSLYFAAPELLKANPYTGPEVDVWSFGVVLFVLVCGKV 342 Query: 410 PF 415 PF Sbjct: 343 PF 344
>SKM1_YEAST (Q12469) Serine/threonine-protein kinase SKM1 (EC 2.7.11.1)| (Protein kinase 75490 D) Length = 655 Score = 81.3 bits (199), Expect = 1e-15 Identities = 47/134 (35%), Positives = 74/134 (55%), Gaps = 8/134 (5%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNR--RQN---RSVPLKLAVKQAL--DVARGMAYVHGLGFIHRDLK 199 ++ Y +GG + + L+ R N S PL + + +G+ ++H IHRD+K Sbjct: 450 VIMEYMEGGCLTDILDAVARSNTGEHSSPLNENQMAYIVKETCQGLKFLHNKKIIHRDIK 509 Query: 200 SDNLLISGDKSIKIADFGVA-RIEVKTEGMTPETGTYRWMAPEMIQHRPYNQKVDVYSFG 376 SDN+L++ +KI DFG + K GT WMAPE++ + Y++KVDV+S G Sbjct: 510 SDNILLNSQGLVKITDFGFCVELTEKRSKRATMVGTPYWMAPEIVNQKGYDEKVDVWSLG 569 Query: 377 IVLWELITGTLPFL 418 I+L E+I G P+L Sbjct: 570 IMLIEMIEGEPPYL 583
>KPC2_CAEEL (P90980) Protein kinase C-like 2 (EC 2.7.11.13) (PKC2)| Length = 682 Score = 80.9 bits (198), Expect = 1e-15 Identities = 39/102 (38%), Positives = 67/102 (65%), Gaps = 1/102 (0%) Frame = +2 Query: 119 LAVKQALDVARGMAYVHGLGFIHRDLKSDNLLISGDKSIKIADFGVARIEVKTEGMTPE- 295 +AV A ++A G+ ++H G I+RDLK DN+++ D IKI DFG+ + + + T Sbjct: 448 VAVFYAAEIAVGLFFLHSKGIIYRDLKLDNVMLERDGHIKITDFGMCKENIFGDATTKTF 507 Query: 296 TGTYRWMAPEMIQHRPYNQKVDVYSFGIVLWELITGTLPFLG 421 GT ++APE+I ++PY + VD +++G++L+E++ G PF G Sbjct: 508 CGTPDYIAPEIILYQPYGKSVDWWAYGVLLFEMLAGQPPFDG 549
>PAK4_HUMAN (O96013) Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1)| (p21-activated kinase 4) (PAK-4) Length = 591 Score = 80.9 bits (198), Expect = 1e-15 Identities = 44/129 (34%), Positives = 75/129 (58%), Gaps = 4/129 (3%) Frame = +2 Query: 41 IVTGYAKGGSVRNFLNR---RQNRSVPLKLAVKQALDVARGMAYVHGLGFIHRDLKSDNL 211 +V + +GG++ + + + + + LAV QAL V +H G IHRD+KSD++ Sbjct: 393 VVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSV------LHAQGVIHRDIKSDSI 446 Query: 212 LISGDKSIKIADFGV-ARIEVKTEGMTPETGTYRWMAPEMIQHRPYNQKVDVYSFGIVLW 388 L++ D +K++DFG A++ + GT WMAPE+I PY +VD++S GI++ Sbjct: 447 LLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVI 506 Query: 389 ELITGTLPF 415 E++ G P+ Sbjct: 507 EMVDGEPPY 515 Database: uniprot_sprot.fasta Posted date: May 25, 2006 5:36 PM Number of letters in database: 80,573,946 Number of sequences in database: 219,361 Lambda K H 0.318 0.135 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 64,971,252 Number of Sequences: 219361 Number of extensions: 1306536 Number of successful extensions: 7962 Number of sequences better than 10.0: 500 Number of HSP's better than 10.0 without gapping: 5973 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 6252 length of database: 80,573,946 effective HSP length: 101 effective length of database: 58,418,485 effective search space used: 2511994855 frameshift window, decay const: 50, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)
